miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106a-5p AKT3 -0.203919267842652 0.802213958426804 0.457269233600447 0.539326812115034 miRNATAP -0.549479065869633 4.88994896864722e-11 NA NA NA hsa-miR-106b-5p AKT3 -0.297128724729339 0.869294443540749 0.457269233600447 0.539326812115034 miRNATAP -0.910251258276316 1.51432008761514e-23 NA NA NA hsa-miR-107 AKT3 -0.0365118169251648 0.988364120226869 0.457269233600447 0.539326812115034 PITA;miRanda -0.551086378595188 0.000172037624489873 NA NA NA hsa-miR-1275 AKT3 -0.831342050607648 0.0803795852164229 0.457269233600447 0.539326812115034 PITA -0.265795172887599 9.47325565176386e-07 NA NA NA hsa-miR-142-3p AKT3 -0.154235241441331 0.946098054588918 0.457269233600447 0.539326812115034 miRanda -0.196043223886578 0.00627089530211866 NA NA NA hsa-miR-15a-5p AKT3 -0.0674049094129128 0.964835434214123 0.457269233600447 0.539326812115034 miRNAWalker2_validate;miRTarBase;miRNATAP -0.721206491484116 7.61586942839311e-13 NA NA NA hsa-miR-15b-5p AKT3 -0.272614787130877 0.87096541832188 0.457269233600447 0.539326812115034 miRNATAP -0.665977383717092 1.97063059627596e-12 NA NA NA hsa-miR-16-5p AKT3 0.0135949734723564 0.994476223855607 0.457269233600447 0.539326812115034 miRNAWalker2_validate;miRTarBase;miRNATAP -0.746124766270904 9.10401236853758e-16 NA NA NA hsa-miR-17-3p AKT3 0.100221625453134 0.960113387014848 0.457269233600447 0.539326812115034 miRNATAP -0.519758313376015 2.03997342351785e-09 NA NA NA hsa-miR-17-5p AKT3 -0.175448849583061 0.934544015912731 0.457269233600447 0.539326812115034 TargetScan;miRNATAP -0.626536048377156 1.11076874125702e-18 NA NA NA hsa-miR-181b-5p AKT3 0.155313039554487 0.930176779696506 0.457269233600447 0.539326812115034 miRNATAP -0.268064668813324 0.00963449049657038 NA NA NA hsa-miR-20a-5p AKT3 -0.179153323927949 0.928118119139752 0.457269233600447 0.539326812115034 miRNATAP -0.531063551395964 1.32783278364081e-13 NA NA NA hsa-miR-28-3p AKT3 -0.227916837431808 0.935350995840384 0.457269233600447 0.539326812115034 miRNATAP -0.521845591393563 0.00718630427898147 NA NA NA hsa-miR-29a-3p AKT3 0.01127474410284 0.996977020481272 0.457269233600447 0.539326812115034 miRNATAP -0.812359982380835 1.03842433672581e-13 NA NA NA hsa-miR-29b-3p AKT3 -0.104016192263954 0.958988036765397 0.457269233600447 0.539326812115034 miRNATAP -0.677276652111253 9.58518141369729e-17 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-32-3p AKT3 -0.568003960723004 0.13133163420273 0.457269233600447 0.539326812115034 mirMAP -0.563455040593992 1.29815959529041e-22 NA NA NA hsa-miR-320a AKT3 -0.416546433767628 0.840202138616422 0.457269233600447 0.539326812115034 PITA;miRanda;miRNATAP -0.333446337886203 0.00137735387479576 NA NA NA hsa-miR-320b AKT3 -0.23561798088153 0.859222532827992 0.457269233600447 0.539326812115034 PITA;miRanda;miRNATAP -0.247020375326149 0.00854841822062789 NA NA NA hsa-miR-335-3p AKT3 -0.244830745789445 0.88450019116631 0.457269233600447 0.539326812115034 mirMAP -0.579661626156677 1.71660731221086e-14 NA NA NA hsa-miR-33a-3p AKT3 -0.794543849238581 0.0105203072007922 0.457269233600447 0.539326812115034 mirMAP -0.48908545949649 5.69174183767199e-12 NA NA NA hsa-miR-340-5p AKT3 -0.00276909425328853 0.99757361161055 0.457269233600447 0.539326812115034 mirMAP -0.282303409119482 0.00600476945925659 NA NA NA hsa-miR-362-3p AKT3 -0.721040238345347 0.0345881362485733 0.457269233600447 0.539326812115034 miRanda -0.415414242264488 1.82625494243827e-09 NA NA NA hsa-miR-362-5p AKT3 -0.26647467080141 0.752024885130738 0.457269233600447 0.539326812115034 PITA;TargetScan;miRNATAP -0.516617267683569 4.2053666241316e-16 NA NA NA hsa-miR-369-3p AKT3 0.116576891957687 0.83230082995912 0.457269233600447 0.539326812115034 mirMAP -0.2347933374382 0.00901179401751285 NA NA NA hsa-miR-374a-5p AKT3 -0.343007247142618 0.766921280269271 0.457269233600447 0.539326812115034 mirMAP -0.579942468779622 2.643062323348e-06 NA NA NA hsa-miR-374b-5p AKT3 -0.285682091626878 0.83569830479965 0.457269233600447 0.539326812115034 mirMAP -0.684416910019692 6.98155817205318e-09 NA NA NA hsa-miR-421 AKT3 -0.182032017078616 0.734704500318599 0.457269233600447 0.539326812115034 miRanda;mirMAP -0.463766741666901 1.36843495165118e-08 NA NA NA hsa-miR-424-5p AKT3 0.247080963500746 0.870154571783568 0.457269233600447 0.539326812115034 miRNATAP -0.239499066096292 0.00104453067376223 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth liver cancer hsa-miR-501-3p AKT3 -0.753812576327832 0.552763280802254 0.457269233600447 0.539326812115034 miRNATAP -0.497935902986368 2.06014814106823e-10 NA NA NA hsa-miR-502-3p AKT3 -0.481234445251923 0.514301076452422 0.457269233600447 0.539326812115034 miRNATAP -0.644160673294049 1.58962279838432e-12 NA NA NA hsa-miR-502-5p AKT3 -0.708507838520586 0.0261309781860104 0.457269233600447 0.539326812115034 PITA;miRNATAP -0.409328372897747 4.31887851181114e-09 NA NA NA hsa-miR-505-3p AKT3 -0.469094267152605 0.690382680489578 0.457269233600447 0.539326812115034 mirMAP -0.774927841273818 6.77311058531751e-15 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-548o-3p AKT3 -0.191447572716994 0.517725546183501 0.457269233600447 0.539326812115034 mirMAP -0.314174287829114 7.58105126731538e-05 NA NA NA hsa-miR-577 AKT3 -1.06238199218774 0.326056761787754 0.457269233600447 0.539326812115034 mirMAP -0.383091519653111 6.42065724452006e-20 NA NA NA hsa-miR-663b AKT3 0.101100389887233 0.814989939749933 0.457269233600447 0.539326812115034 PITA -0.247711064601903 1.07528758067609e-05 NA NA NA hsa-miR-769-5p AKT3 -0.306614906942583 0.735704301598833 0.457269233600447 0.539326812115034 PITA;miRNATAP -0.8409977584726 1.11686042031466e-14 NA NA NA hsa-miR-93-5p AKT3 -0.611073677204699 0.825297877093193 0.457269233600447 0.539326812115034 miRNATAP -0.762020096686085 6.75211862260925e-18 NA NA NA hsa-miR-335-5p ARRB1 -0.0284895175847679 0.973380867832231 -0.317024422244706 0.771570426734776 miRNAWalker2_validate -0.123241652276708 0.00396685216257832 NA NA NA hsa-let-7a-3p ATF2 -0.215598045625677 0.85543299203799 -0.200040241393686 0.834704017881278 MirTarget;mirMAP;miRNATAP -0.145456257908776 3.85637550129781e-05 NA NA NA hsa-miR-126-5p ATF2 0.0815213541035824 0.956637332055185 -0.200040241393686 0.834704017881278 mirMAP -0.181642145637599 9.06926162170161e-06 NA NA NA hsa-miR-154-3p ATF2 -0.170366170038505 0.546500133020447 -0.200040241393686 0.834704017881278 MirTarget;miRNATAP -0.105577992235569 0.000669146651960108 NA NA NA hsa-miR-15a-5p ATF2 -0.0674049094129128 0.964835434214123 -0.200040241393686 0.834704017881278 miRNAWalker2_validate -0.118857602902957 0.00217641297884977 NA NA NA hsa-miR-221-3p ATF2 0.0906940388127513 0.959121118272534 -0.200040241393686 0.834704017881278 MirTarget -0.145107508084311 0.000241689651077263 NA NA NA hsa-miR-222-3p ATF2 -0.0265849318772702 0.984005474689108 -0.200040241393686 0.834704017881278 MirTarget -0.148058599020819 2.60269631326679e-05 NA NA NA hsa-miR-26a-5p ATF2 0.00698202897993028 0.997719986197021 -0.200040241393686 0.834704017881278 MirTarget;miRNATAP -0.197558729223936 0.00157372163841153 NA NA NA hsa-miR-26b-5p ATF2 -0.0245931278499594 0.990377966314923 -0.200040241393686 0.834704017881278 MirTarget;miRNATAP -0.183301474614023 1.68583844133298e-05 21901137 Coordinated regulation of ATF2 by miR 26b in γ irradiated lung cancer cells; Concurrent analysis of time-series mRNA and microRNA profiles uncovered that expression of miR-26b was down regulated and its target activating transcription factor 2 ATF2 mRNA was up regulated in γ-irradiated H1299 cells; IR in miR-26b overexpressed H1299 cells could not induce expression of ATF2; From these results we concluded that IR-induced up-regulation of ATF2 was coordinately enhanced by suppression of miR-26b in lung cancer cells which may enhance the effect of IR in the MAPK signaling pathway lung cancer hsa-miR-29a-5p ATF2 -0.31835175571979 0.600442757817281 -0.200040241393686 0.834704017881278 MirTarget;miRNATAP -0.120323969461232 3.64182445454902e-05 NA NA NA hsa-miR-30b-5p ATF2 -0.0121430518253582 0.994622896704513 -0.200040241393686 0.834704017881278 mirMAP -0.16085794620541 2.13160957950525e-07 NA NA NA hsa-miR-30c-5p ATF2 -0.298383882401475 0.865809030482001 -0.200040241393686 0.834704017881278 mirMAP -0.202383254510825 6.22899764468817e-06 NA NA NA hsa-miR-32-3p ATF2 -0.568003960723004 0.13133163420273 -0.200040241393686 0.834704017881278 miRNATAP -0.113919762669886 6.39435255124837e-07 NA NA NA hsa-miR-369-3p ATF2 0.116576891957687 0.83230082995912 -0.200040241393686 0.834704017881278 MirTarget;PITA;miRNATAP -0.189727252765993 3.13392227089755e-09 NA NA NA hsa-miR-374b-5p ATF2 -0.285682091626878 0.83569830479965 -0.200040241393686 0.834704017881278 miRNAWalker2_validate;mirMAP;miRNATAP -0.152741878528855 0.000604480562649164 NA NA NA hsa-let-7a-3p BDNF -0.215598045625677 0.85543299203799 0.502522334318129 0.169334891177907 MirTarget;miRNATAP -0.244157318378319 0.00935451173762819 NA NA NA hsa-miR-15a-5p BDNF -0.0674049094129128 0.964835434214123 0.502522334318129 0.169334891177907 MirTarget;miRNATAP -0.355665776038132 0.000462651707811393 26581909 MicroRNA 15a 5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF; BDNF was then overexpressed in HepG2 and SNU-182 cells to evaluate its selective effect on miR-15a-5p in HCC modulation; MiR-15a-5p selectively and negatively regulated BDNF at both gene and protein levels in HCC cells; Forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-15a-5p on HCC proliferation and cell division in vitro; Our study demonstrated that miR-15a-5p is a tumor suppressor in HCC and its regulation is through BDNF in HCC liver cancer hsa-miR-15b-5p BDNF -0.272614787130877 0.87096541832188 0.502522334318129 0.169334891177907 MirTarget;miRNATAP -0.321617462225248 0.000753073059525485 NA NA NA hsa-miR-16-5p BDNF 0.0135949734723564 0.994476223855607 0.502522334318129 0.169334891177907 MirTarget;miRNATAP -0.341750126964866 0.000321385062215879 NA NA NA hsa-miR-191-5p BDNF -0.482483793839469 0.815353309051705 0.502522334318129 0.169334891177907 miRNATAP -0.334294944807502 0.000226992770607199 NA NA NA hsa-miR-210-3p BDNF -0.531610638853144 0.78220772117333 0.502522334318129 0.169334891177907 miRNAWalker2_validate;miRTarBase -0.183642191494302 0.0001042604221863 NA NA NA hsa-miR-26b-3p BDNF -0.363222538866814 0.681115126930068 0.502522334318129 0.169334891177907 MirTarget -0.268475122696643 0.00218986725906013 NA NA NA hsa-miR-29b-1-5p BDNF -0.642348119412534 0.293891497238796 0.502522334318129 0.169334891177907 mirMAP -0.212902366897635 0.000389282449514205 NA NA NA hsa-miR-30b-5p BDNF -0.0121430518253582 0.994622896704513 0.502522334318129 0.169334891177907 miRNATAP -0.260284489869932 0.00172972096789126 NA NA NA hsa-miR-32-3p BDNF -0.568003960723004 0.13133163420273 0.502522334318129 0.169334891177907 miRNATAP -0.291628274452174 1.27978861287945e-06 NA NA NA hsa-miR-339-5p BDNF -0.300425087100667 0.712912847076788 0.502522334318129 0.169334891177907 miRanda -0.263405527708753 0.000132027992538123 NA NA NA hsa-miR-33a-3p BDNF -0.794543849238581 0.0105203072007922 0.502522334318129 0.169334891177907 mirMAP -0.189014402176148 0.0084884107105508 NA NA NA hsa-miR-452-3p BDNF -0.167134177977311 0.799008246175244 0.502522334318129 0.169334891177907 MirTarget -0.167787891127089 0.00525081101096434 NA NA NA hsa-miR-577 BDNF -1.06238199218774 0.326056761787754 0.502522334318129 0.169334891177907 mirMAP;miRNATAP -0.178001475560175 4.47308472492026e-05 NA NA NA hsa-miR-589-3p BDNF -0.835836305204965 0.0112001563801511 0.502522334318129 0.169334891177907 MirTarget -0.292493758312755 6.69029402753748e-06 NA NA NA hsa-miR-589-5p BDNF -0.448771545046784 0.722725226273464 0.502522334318129 0.169334891177907 miRNATAP -0.37518450820671 0.00123645876452662 NA NA NA hsa-miR-590-3p BDNF -0.279244755376859 0.59126669933662 0.502522334318129 0.169334891177907 miRanda;mirMAP;miRNATAP -0.323632810694054 3.35708815948861e-06 NA NA NA hsa-miR-7-1-3p BDNF -0.462485777435991 0.665899751398166 0.502522334318129 0.169334891177907 MirTarget -0.33546008099557 4.33647161661503e-05 NA NA NA hsa-miR-146b-5p BRAF -0.402662509440887 0.837510937985091 -0.0369210741861203 0.948963691154135 miRanda -0.118645199623624 0.00232493560804849 21874046;26883911;20406109;21537871 Additionally the activation of thyroid most common oncogenes RET/PTC3 and BRAF in PCCL3 cells upregulated miR-146b-5p expression;miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells independently from their original mutation either BRAF or RET/PTC through a mechanism that involves the actin cytoskeleton but not an increased capacity of matrix degradation;The miR-146b expression levels in PTCs with BRAF mutation were significantly higher than those without this mutation p < 0.0001;Among BRAF-positive tumors overexpression of miR-146b was associated with aggressive behavior suggesting that it may further refine the prognostic importance of BRAF ;;; thyroid cancer;thyroid cancer;thyroid cancer;thyroid cancer hsa-miR-199a-5p BRAF 0.157247797504494 0.935797462797012 -0.0369210741861203 0.948963691154135 miRanda -0.10031453288356 0.00847963162022019 NA NA NA hsa-miR-199b-5p BRAF -0.0396557270992508 0.977172718873203 -0.0369210741861203 0.948963691154135 miRanda -0.122525543794023 0.00019945402288156 NA NA NA hsa-miR-130b-5p CACNA1A -0.6472141103776 0.379096015222509 0.0993488675688106 0.853091743738106 mirMAP -0.379824293356973 7.37543586444325e-05 NA NA NA hsa-miR-16-2-3p CACNA1A -0.36717860153421 0.546850726070016 0.0993488675688106 0.853091743738106 mirMAP -0.290431820452548 0.00147536181394799 NA NA NA hsa-miR-188-5p CACNA1A -0.568517670542551 0.324820848307954 0.0993488675688106 0.853091743738106 PITA -0.250595449242126 0.00064234728789404 NA NA NA hsa-miR-339-5p CACNA1A -0.300425087100667 0.712912847076788 0.0993488675688106 0.853091743738106 mirMAP -0.223649597364279 0.0062500518579802 NA NA NA hsa-miR-590-3p CACNA1A -0.279244755376859 0.59126669933662 0.0993488675688106 0.853091743738106 miRanda -0.26824540465463 0.00123475557611211 NA NA NA hsa-miR-92a-1-5p CACNA1A -0.114476130048015 0.848528800127198 0.0993488675688106 0.853091743738106 mirMAP -0.245523063700757 0.00167963252443999 NA NA NA hsa-miR-107 CACNA1B -0.0365118169251648 0.988364120226869 0.762962744029398 0.453073880199436 miRanda -1.28699673665137 4.76483537726776e-06 NA NA NA hsa-miR-141-3p CACNA1B -0.31994058840327 0.87774106909065 0.762962744029398 0.453073880199436 mirMAP -0.602984260436025 2.23532309494353e-05 NA NA NA hsa-miR-185-3p CACNA1B 0.100697585937245 0.856913315942984 0.762962744029398 0.453073880199436 MirTarget -0.532527824306112 0.00216166536521265 NA NA NA hsa-miR-18a-5p CACNA1B -0.498318455303917 0.61264091975585 0.762962744029398 0.453073880199436 mirMAP -0.434813268410734 0.000425660191577503 NA NA NA hsa-miR-18b-5p CACNA1B -0.0473300652227538 0.899981261531446 0.762962744029398 0.453073880199436 mirMAP -0.363186245732283 0.0027541833466712 NA NA NA hsa-miR-197-3p CACNA1B -0.455489147957159 0.794916582095149 0.762962744029398 0.453073880199436 mirMAP -0.526069521213476 0.00425575087714403 NA NA NA hsa-miR-200a-3p CACNA1B -0.367034437440907 0.851059894150266 0.762962744029398 0.453073880199436 mirMAP -0.394068007772319 0.00490294740017372 NA NA NA hsa-miR-335-3p CACNA1B -0.244830745789445 0.88450019116631 0.762962744029398 0.453073880199436 mirMAP -0.577123189935456 0.000170105564233695 NA NA NA hsa-miR-362-3p CACNA1B -0.721040238345347 0.0345881362485733 0.762962744029398 0.453073880199436 MirTarget;miRNATAP -0.392232486575988 0.00442451696681813 NA NA NA hsa-miR-429 CACNA1B -0.456485631615963 0.806240953400535 0.762962744029398 0.453073880199436 miRNATAP -0.413865589419287 0.00196720690311037 NA NA NA hsa-miR-589-3p CACNA1B -0.835836305204965 0.0112001563801511 0.762962744029398 0.453073880199436 MirTarget -0.572449698889362 1.06944547929185e-05 NA NA NA hsa-miR-590-3p CACNA1B -0.279244755376859 0.59126669933662 0.762962744029398 0.453073880199436 miRanda -0.642291176427577 4.01764192436983e-06 NA NA NA hsa-miR-7-1-3p CACNA1B -0.462485777435991 0.665899751398166 0.762962744029398 0.453073880199436 MirTarget -0.566123744897813 0.000601172944518257 NA NA NA hsa-miR-940 CACNA1B -0.225788347550697 0.680055767105815 0.762962744029398 0.453073880199436 MirTarget -0.334434390257356 0.00581906947118054 NA NA NA hsa-let-7f-1-3p CACNA1C -0.31101436822914 0.693407210545374 0.624130328975345 0.478285757372737 MirTarget -0.538486984083454 0.000157315241725836 NA NA NA hsa-miR-107 CACNA1C -0.0365118169251648 0.988364120226869 0.624130328975345 0.478285757372737 miRNATAP -0.641812776212623 5.07573256721182e-05 NA NA NA hsa-miR-1254 CACNA1C -0.488929355953681 0.19551794273322 0.624130328975345 0.478285757372737 PITA;miRNATAP -0.380621715734654 2.55450574340971e-07 NA NA NA hsa-miR-148b-5p CACNA1C -0.236618793990305 0.43925706879726 0.624130328975345 0.478285757372737 mirMAP -0.404677603083841 2.13167237967464e-06 NA NA NA hsa-miR-186-5p CACNA1C -0.318786974828757 0.85412722938961 0.624130328975345 0.478285757372737 mirMAP -0.699518379325971 7.75531009889311e-08 NA NA NA hsa-miR-192-5p CACNA1C -0.117345487848223 0.972927287653137 0.624130328975345 0.478285757372737 mirMAP -0.412218289909836 1.75079712079999e-08 NA NA NA hsa-miR-1976 CACNA1C -0.283448756688618 0.707004130216603 0.624130328975345 0.478285757372737 MirTarget -0.48153129371532 8.69693006587205e-06 NA NA NA hsa-miR-19a-3p CACNA1C -0.206793507801887 0.844637784802316 0.624130328975345 0.478285757372737 MirTarget -0.500490193209649 4.22879131818591e-11 NA NA NA hsa-miR-19b-1-5p CACNA1C -0.0105982583216702 0.988511655226679 0.624130328975345 0.478285757372737 MirTarget -0.523886535438849 6.00898566126366e-10 NA NA NA hsa-miR-19b-3p CACNA1C -0.0268530183621474 0.986656783046572 0.624130328975345 0.478285757372737 MirTarget -0.447035252849047 1.47206088615385e-06 NA NA NA hsa-miR-200b-3p CACNA1C -0.426401948379212 0.863957108574195 0.624130328975345 0.478285757372737 MirTarget;TargetScan -0.291935841323447 0.00158565556360695 NA NA NA hsa-miR-200c-3p CACNA1C -0.437282635857873 0.887118598436407 0.624130328975345 0.478285757372737 MirTarget -0.50946402949112 4.28802024459478e-08 NA NA NA hsa-miR-26b-5p CACNA1C -0.0245931278499594 0.990377966314923 0.624130328975345 0.478285757372737 MirTarget;miRNATAP -0.343330447367806 0.0068700000867796 NA NA NA hsa-miR-29a-3p CACNA1C 0.01127474410284 0.996977020481272 0.624130328975345 0.478285757372737 MirTarget -0.34982395309806 0.00502873017724976 NA NA NA hsa-miR-29b-3p CACNA1C -0.104016192263954 0.958988036765397 0.624130328975345 0.478285757372737 MirTarget -0.459209281245035 7.23613083242062e-07 NA NA NA hsa-miR-30d-5p CACNA1C -0.168211838771867 0.95173197030375 0.624130328975345 0.478285757372737 mirMAP -0.320373176342599 0.00783690102610719 NA NA NA hsa-miR-330-5p CACNA1C -0.283418953659271 0.815687101334695 0.624130328975345 0.478285757372737 miRanda -0.414774821290604 0.000814648710569312 NA NA NA hsa-miR-33a-5p CACNA1C -0.205788753603336 0.853314500865147 0.624130328975345 0.478285757372737 MirTarget -0.192161195720388 0.000161463272206909 NA NA NA hsa-miR-33b-5p CACNA1C -0.161971614375297 0.737436207821109 0.624130328975345 0.478285757372737 MirTarget -0.174587431501542 0.0020957031659676 NA NA NA hsa-miR-361-3p CACNA1C -0.285313945920494 0.847726816983044 0.624130328975345 0.478285757372737 MirTarget -0.393222875191418 0.00491573454383393 NA NA NA hsa-miR-378a-5p CACNA1C -0.559739196974497 0.724882066659501 0.624130328975345 0.478285757372737 MirTarget -0.398675743851849 3.13218307915181e-05 NA NA NA hsa-miR-421 CACNA1C -0.182032017078616 0.734704500318599 0.624130328975345 0.478285757372737 MirTarget;PITA;miRanda;miRNATAP -0.497141924527352 1.94004970571647e-08 NA NA NA hsa-miR-429 CACNA1C -0.456485631615963 0.806240953400535 0.624130328975345 0.478285757372737 MirTarget;PITA;miRanda;miRNATAP -0.302820431013423 4.59831013283736e-05 NA NA NA hsa-miR-450b-5p CACNA1C -0.0136687538973108 0.983149761399849 0.624130328975345 0.478285757372737 PITA;miRNATAP -0.309417178688936 0.00172272153433166 NA NA NA hsa-miR-484 CACNA1C -0.179977202691249 0.886333755572375 0.624130328975345 0.478285757372737 PITA;miRNATAP -0.586734428676188 4.58813858592665e-07 NA NA NA hsa-miR-532-5p CACNA1C -0.349665553500088 0.878948352437467 0.624130328975345 0.478285757372737 PITA -0.539869637099344 4.4699626319453e-09 NA NA NA hsa-miR-542-3p CACNA1C 0.188168046511374 0.909252939431573 0.624130328975345 0.478285757372737 miRanda -0.481211290752225 2.49018005258875e-05 NA NA NA hsa-miR-577 CACNA1C -1.06238199218774 0.326056761787754 0.624130328975345 0.478285757372737 PITA -0.203888749206192 2.95389870763068e-05 NA NA NA hsa-miR-589-3p CACNA1C -0.835836305204965 0.0112001563801511 0.624130328975345 0.478285757372737 MirTarget;mirMAP -0.526657751428396 4.77475561871967e-14 NA NA NA hsa-miR-660-5p CACNA1C -0.476129334484339 0.694082832658925 0.624130328975345 0.478285757372737 MirTarget -0.576257938415985 1.04574382099295e-09 NA NA NA hsa-miR-671-3p CACNA1C -0.436798879412884 0.242347190629487 0.624130328975345 0.478285757372737 miRNATAP -0.328287937073989 0.000909096429412067 NA NA NA hsa-miR-7-1-3p CACNA1C -0.462485777435991 0.665899751398166 0.624130328975345 0.478285757372737 MirTarget -0.432826918234288 2.13920980608042e-06 NA NA NA hsa-miR-877-5p CACNA1C -0.317720731672575 0.435952264022643 0.624130328975345 0.478285757372737 MirTarget -0.304078321369568 8.383877851918e-06 NA NA NA hsa-miR-93-3p CACNA1C -0.438355548962673 0.549902689385444 0.624130328975345 0.478285757372737 mirMAP -0.467917318911282 1.98780488491556e-07 NA NA NA hsa-miR-96-5p CACNA1C 0.0854810872029343 0.923087820185031 0.624130328975345 0.478285757372737 MirTarget;TargetScan -0.392963105530334 8.74568575661908e-07 NA NA NA hsa-miR-342-3p CACNA1D -0.371626144515113 0.77313668985267 -0.248973272993721 0.782987635507991 miRanda -0.294188377504038 0.00138788446439745 NA NA NA hsa-miR-625-5p CACNA1D -0.690759472145277 0.210306534567564 -0.248973272993721 0.782987635507991 MirTarget -0.227735355148671 0.00062462592953205 NA NA NA hsa-let-7f-5p CACNA1E 0.048789917034723 0.987280455481631 -0.0224970248470513 0.972637163029998 miRNATAP -0.943596126265178 1.30359802222787e-05 NA NA NA hsa-let-7g-5p CACNA1E -0.200947212961157 0.922992045181955 -0.0224970248470513 0.972637163029998 miRNATAP -1.04155008336218 1.95684238265677e-06 NA NA NA hsa-miR-106a-5p CACNA1E -0.203919267842652 0.802213958426804 -0.0224970248470513 0.972637163029998 mirMAP -0.455792742671822 0.00113700018089824 NA NA NA hsa-miR-106b-5p CACNA1E -0.297128724729339 0.869294443540749 -0.0224970248470513 0.972637163029998 mirMAP -0.880243854028761 2.8207088935081e-08 NA NA NA hsa-miR-1266-5p CACNA1E -0.749998297098308 0.475802062565143 -0.0224970248470513 0.972637163029998 MirTarget -0.267175863348595 0.00932880345516004 NA NA NA hsa-miR-1304-5p CACNA1E -0.497887681787993 0.163079003594721 -0.0224970248470513 0.972637163029998 mirMAP -0.305212957190815 0.00343434416827501 NA NA NA hsa-miR-130b-5p CACNA1E -0.6472141103776 0.379096015222509 -0.0224970248470513 0.972637163029998 miRNATAP -0.414813299335591 0.00247560820976051 NA NA NA hsa-miR-135b-5p CACNA1E 0.631573976263484 0.610028066417462 -0.0224970248470513 0.972637163029998 miRNATAP -0.248188251845311 0.00407333975295756 NA NA NA hsa-miR-141-3p CACNA1E -0.31994058840327 0.87774106909065 -0.0224970248470513 0.972637163029998 MirTarget;TargetScan;miRNATAP -0.663661693956075 1.41006865062555e-08 NA NA NA hsa-miR-141-5p CACNA1E -0.354590233549885 0.867642456336402 -0.0224970248470513 0.972637163029998 mirMAP -0.572671580158729 6.31736934675198e-06 NA NA NA hsa-miR-148a-3p CACNA1E -0.101286586375016 0.976980454193186 -0.0224970248470513 0.972637163029998 mirMAP -0.595569828753682 3.54728455389988e-05 NA NA NA hsa-miR-148b-3p CACNA1E -0.202106692287125 0.911884960581838 -0.0224970248470513 0.972637163029998 mirMAP -0.62914785107503 0.00225918070209572 NA NA NA hsa-miR-148b-5p CACNA1E -0.236618793990305 0.43925706879726 -0.0224970248470513 0.972637163029998 mirMAP -0.361616160706065 0.0052405248256932 NA NA NA hsa-miR-15a-5p CACNA1E -0.0674049094129128 0.964835434214123 -0.0224970248470513 0.972637163029998 MirTarget -0.851039648064768 3.59250533524536e-07 NA NA NA hsa-miR-15b-5p CACNA1E -0.272614787130877 0.87096541832188 -0.0224970248470513 0.972637163029998 MirTarget -0.581247410229415 0.000261507155366133 NA NA NA hsa-miR-16-2-3p CACNA1E -0.36717860153421 0.546850726070016 -0.0224970248470513 0.972637163029998 mirMAP -0.463041243164511 0.000342064165844067 NA NA NA hsa-miR-16-5p CACNA1E 0.0135949734723564 0.994476223855607 -0.0224970248470513 0.972637163029998 MirTarget -0.751608337860365 1.7006165860131e-06 NA NA NA hsa-miR-17-3p CACNA1E 0.100221625453134 0.960113387014848 -0.0224970248470513 0.972637163029998 miRNATAP -0.513891696894819 0.000351011558248978 NA NA NA hsa-miR-17-5p CACNA1E -0.175448849583061 0.934544015912731 -0.0224970248470513 0.972637163029998 mirMAP -0.56155034045818 4.25305272281854e-06 NA NA NA hsa-miR-182-5p CACNA1E -0.104238497940557 0.973380614062243 -0.0224970248470513 0.972637163029998 mirMAP;miRNATAP -0.359501285119302 0.00396618716810383 NA NA NA hsa-miR-186-5p CACNA1E -0.318786974828757 0.85412722938961 -0.0224970248470513 0.972637163029998 mirMAP -0.65253259390245 0.000998806342964261 NA NA NA hsa-miR-19a-3p CACNA1E -0.206793507801887 0.844637784802316 -0.0224970248470513 0.972637163029998 mirMAP -0.430669729387494 0.000235302334483428 NA NA NA hsa-miR-19b-3p CACNA1E -0.0268530183621474 0.986656783046572 -0.0224970248470513 0.972637163029998 mirMAP -0.654125830123007 2.40231647445615e-06 NA NA NA hsa-miR-200a-3p CACNA1E -0.367034437440907 0.851059894150266 -0.0224970248470513 0.972637163029998 MirTarget;miRNATAP -0.433606579980873 0.000192717654121995 NA NA NA hsa-miR-200a-5p CACNA1E -0.671005453811576 0.78126028567661 -0.0224970248470513 0.972637163029998 mirMAP -0.407064108805685 0.00169296784345275 NA NA NA hsa-miR-200b-5p CACNA1E -0.502275384207405 0.722255155236927 -0.0224970248470513 0.972637163029998 mirMAP -0.502812743910852 7.97169167500921e-05 NA NA NA hsa-miR-200c-5p CACNA1E -1.06750203254758 0.417719716654428 -0.0224970248470513 0.972637163029998 mirMAP -0.362954071912988 0.00144762154352612 NA NA NA hsa-miR-20a-5p CACNA1E -0.179153323927949 0.928118119139752 -0.0224970248470513 0.972637163029998 mirMAP -0.550008601845918 4.86896805977246e-06 NA NA NA hsa-miR-29a-5p CACNA1E -0.31835175571979 0.600442757817281 -0.0224970248470513 0.972637163029998 mirMAP -0.566895702175995 8.9335835895942e-06 NA NA NA hsa-miR-30d-3p CACNA1E -0.123474741320298 0.814905367625791 -0.0224970248470513 0.972637163029998 MirTarget;mirMAP;miRNATAP -0.465787468291637 0.00313293761947586 NA NA NA hsa-miR-32-3p CACNA1E -0.568003960723004 0.13133163420273 -0.0224970248470513 0.972637163029998 mirMAP -0.30725854388395 0.00267608461088065 NA NA NA hsa-miR-335-3p CACNA1E -0.244830745789445 0.88450019116631 -0.0224970248470513 0.972637163029998 mirMAP -0.511482056585536 6.49067780362749e-05 NA NA NA hsa-miR-362-5p CACNA1E -0.26647467080141 0.752024885130738 -0.0224970248470513 0.972637163029998 mirMAP -0.519186082896806 1.40191838675181e-06 NA NA NA hsa-miR-374a-3p CACNA1E -0.118320910531011 0.958176637009264 -0.0224970248470513 0.972637163029998 mirMAP -0.657620661248411 2.37646408068979e-06 NA NA NA hsa-miR-374a-5p CACNA1E -0.343007247142618 0.766921280269271 -0.0224970248470513 0.972637163029998 mirMAP -0.839304419240939 2.84081789670165e-05 NA NA NA hsa-miR-374b-5p CACNA1E -0.285682091626878 0.83569830479965 -0.0224970248470513 0.972637163029998 mirMAP -0.708219647902072 0.000288635767973924 NA NA NA hsa-miR-421 CACNA1E -0.182032017078616 0.734704500318599 -0.0224970248470513 0.972637163029998 mirMAP -0.393247700006028 0.00372149287597723 NA NA NA hsa-miR-424-5p CACNA1E 0.247080963500746 0.870154571783568 -0.0224970248470513 0.972637163029998 MirTarget -0.365046017310115 0.00201094243114566 NA NA NA hsa-miR-425-5p CACNA1E -0.354606074344121 0.845979106734409 -0.0224970248470513 0.972637163029998 mirMAP -0.545425296608196 2.13370188447364e-05 NA NA NA hsa-miR-491-3p CACNA1E -0.513850326596847 0.137836285146052 -0.0224970248470513 0.972637163029998 mirMAP -0.401506243319489 0.000680912530916512 NA NA NA hsa-miR-542-3p CACNA1E 0.188168046511374 0.909252939431573 -0.0224970248470513 0.972637163029998 mirMAP -0.478402134965976 0.00549301173800206 NA NA NA hsa-miR-550a-3p CACNA1E -0.6199901113685 0.0836206511566976 -0.0224970248470513 0.972637163029998 mirMAP -0.406602774270333 0.000541948990491883 NA NA NA hsa-miR-577 CACNA1E -1.06238199218774 0.326056761787754 -0.0224970248470513 0.972637163029998 mirMAP -0.278959896841242 0.000134992787980458 NA NA NA hsa-miR-589-3p CACNA1E -0.835836305204965 0.0112001563801511 -0.0224970248470513 0.972637163029998 mirMAP -0.41433185734036 0.000150410414762082 NA NA NA hsa-miR-590-3p CACNA1E -0.279244755376859 0.59126669933662 -0.0224970248470513 0.972637163029998 miRanda -0.43443438616819 0.000216750535041615 NA NA NA hsa-miR-590-5p CACNA1E -0.547819833829572 0.472735645776647 -0.0224970248470513 0.972637163029998 miRanda;mirMAP -0.560642046893189 5.36966553980693e-06 NA NA NA hsa-miR-592 CACNA1E -0.177670083168544 0.856226890424691 -0.0224970248470513 0.972637163029998 mirMAP -0.205238406542128 0.000542667496643315 NA NA NA hsa-miR-660-5p CACNA1E -0.476129334484339 0.694082832658925 -0.0224970248470513 0.972637163029998 mirMAP -0.501435973128813 0.000542947333759499 NA NA NA hsa-miR-7-1-3p CACNA1E -0.462485777435991 0.665899751398166 -0.0224970248470513 0.972637163029998 mirMAP -0.493794269683389 0.000337842672584135 NA NA NA hsa-miR-7-5p CACNA1E 0.209645143210379 0.773705612298441 -0.0224970248470513 0.972637163029998 mirMAP -0.291412521193573 0.000962395316405768 NA NA NA hsa-miR-92a-1-5p CACNA1E -0.114476130048015 0.848528800127198 -0.0224970248470513 0.972637163029998 mirMAP -0.32435399096695 0.00351566836226889 NA NA NA hsa-miR-93-5p CACNA1E -0.611073677204699 0.825297877093193 -0.0224970248470513 0.972637163029998 mirMAP -0.62141103387287 4.46111734566619e-05 NA NA NA hsa-miR-942-5p CACNA1E -0.50502396741886 0.50777904281306 -0.0224970248470513 0.972637163029998 MirTarget -0.422391693143347 0.000292568697271788 NA NA NA hsa-miR-96-5p CACNA1E 0.0854810872029343 0.923087820185031 -0.0224970248470513 0.972637163029998 miRNATAP -0.549935428399096 4.30474477080382e-06 NA NA NA hsa-miR-32-5p CACNA1H -0.05993267619119 0.952975951594959 0.404899097819362 0.663401602253616 miRNATAP -0.560313021335599 4.32067873989856e-10 NA NA NA hsa-miR-361-3p CACNA1H -0.285313945920494 0.847726816983044 0.404899097819362 0.663401602253616 MirTarget;mirMAP -0.478287107712589 0.000605031415246831 NA NA NA hsa-miR-92a-3p CACNA1H 0.0278830870766349 0.993247426671713 0.404899097819362 0.663401602253616 miRNATAP -0.701136270113419 3.74599931258314e-14 NA NA NA hsa-let-7g-5p CACNA1I -0.200947212961157 0.922992045181955 0.893889072248416 0.240341019334448 miRNATAP -0.61035700797192 0.00325067606508853 NA NA NA hsa-miR-141-3p CACNA1I -0.31994058840327 0.87774106909065 0.893889072248416 0.240341019334448 TargetScan -0.38103837678942 0.000643637324003022 NA NA NA hsa-miR-148b-3p CACNA1I -0.202106692287125 0.911884960581838 0.893889072248416 0.240341019334448 mirMAP -0.599675673576368 0.00179060387442206 NA NA NA hsa-miR-182-5p CACNA1I -0.104238497940557 0.973380614062243 0.893889072248416 0.240341019334448 mirMAP -0.451899139837206 9.06521335076908e-05 NA NA NA hsa-miR-96-5p CACNA1I 0.0854810872029343 0.923087820185031 0.893889072248416 0.240341019334448 mirMAP -0.432429831080706 0.000119085216063475 NA NA NA hsa-let-7a-3p CACNA2D1 -0.215598045625677 0.85543299203799 0.211496228686086 0.752243863025546 mirMAP -1.23589254201515 1.4930895850117e-13 NA NA NA hsa-let-7f-1-3p CACNA2D1 -0.31101436822914 0.693407210545374 0.211496228686086 0.752243863025546 mirMAP -1.43466534047361 6.95649518736927e-10 NA NA NA hsa-miR-103a-3p CACNA2D1 -0.0763197091351717 0.980693102700275 0.211496228686086 0.752243863025546 miRNATAP -0.991821294269006 1.85859911069513e-05 NA NA NA hsa-miR-107 CACNA2D1 -0.0365118169251648 0.988364120226869 0.211496228686086 0.752243863025546 PITA;miRanda;miRNATAP -1.17311726526641 9.27847791985394e-06 NA NA NA hsa-miR-126-5p CACNA2D1 0.0815213541035824 0.956637332055185 0.211496228686086 0.752243863025546 mirMAP -0.726568015254832 0.000359419072791252 NA NA NA hsa-miR-141-3p CACNA2D1 -0.31994058840327 0.87774106909065 0.211496228686086 0.752243863025546 TargetScan -1.23683601793874 2.89544248048612e-24 NA NA NA hsa-miR-16-2-3p CACNA2D1 -0.36717860153421 0.546850726070016 0.211496228686086 0.752243863025546 mirMAP -1.20377814124186 4.68119980868137e-19 NA NA NA hsa-miR-16-5p CACNA2D1 0.0135949734723564 0.994476223855607 0.211496228686086 0.752243863025546 miRNAWalker2_validate -1.44357183205824 4.50159765145706e-18 NA NA NA hsa-miR-182-5p CACNA2D1 -0.104238497940557 0.973380614062243 0.211496228686086 0.752243863025546 miRNATAP -0.679569091569225 7.99766538028916e-07 NA NA NA hsa-miR-200b-3p CACNA2D1 -0.426401948379212 0.863957108574195 0.211496228686086 0.752243863025546 TargetScan -1.30134956811578 9.02421722878998e-20 NA NA NA hsa-miR-21-3p CACNA2D1 -0.395016549347053 0.87819982773565 0.211496228686086 0.752243863025546 mirMAP -1.03259674589521 2.17182854243257e-08 NA NA NA hsa-miR-23a-3p CACNA2D1 -0.122198715333656 0.962717452143511 0.211496228686086 0.752243863025546 mirMAP -1.10082583506724 0.000173542927966024 NA NA NA hsa-miR-26b-5p CACNA2D1 -0.0245931278499594 0.990377966314923 0.211496228686086 0.752243863025546 mirMAP -1.67878646349773 2.52661939406891e-17 NA NA NA hsa-miR-30d-3p CACNA2D1 -0.123474741320298 0.814905367625791 0.211496228686086 0.752243863025546 mirMAP -1.1546190472698 1.06492102489345e-11 NA NA NA hsa-miR-30e-3p CACNA2D1 -0.220498559176349 0.938660731870214 0.211496228686086 0.752243863025546 mirMAP -1.25625951945399 1.37891188103749e-05 NA NA NA hsa-miR-32-3p CACNA2D1 -0.568003960723004 0.13133163420273 0.211496228686086 0.752243863025546 mirMAP -1.0868559914761 3.83861307096451e-26 NA NA NA hsa-miR-330-3p CACNA2D1 0.00298687748748416 0.994504006750491 0.211496228686086 0.752243863025546 mirMAP -0.629676353050821 0.000276271470477742 NA NA NA hsa-miR-335-3p CACNA2D1 -0.244830745789445 0.88450019116631 0.211496228686086 0.752243863025546 mirMAP -0.883002047613826 2.92781674726446e-10 NA NA NA hsa-miR-338-3p CACNA2D1 0.49158501750012 0.788483749194189 0.211496228686086 0.752243863025546 miRanda -0.359349899520668 0.00235199535230882 NA NA NA hsa-miR-33a-3p CACNA2D1 -0.794543849238581 0.0105203072007922 0.211496228686086 0.752243863025546 mirMAP -0.906946746427537 1.74367524444745e-12 NA NA NA hsa-miR-362-3p CACNA2D1 -0.721040238345347 0.0345881362485733 0.211496228686086 0.752243863025546 miRanda -0.784210206003904 3.49095170020869e-10 NA NA NA hsa-miR-377-3p CACNA2D1 -0.0435868040110954 0.893514136702459 0.211496228686086 0.752243863025546 mirMAP -0.421795206133037 0.00265575424084347 NA NA NA hsa-miR-450b-5p CACNA2D1 -0.0136687538973108 0.983149761399849 0.211496228686086 0.752243863025546 mirMAP -0.447658627007169 0.00700580026968268 NA NA NA hsa-miR-508-3p CACNA2D1 0.435816908385962 0.551135837633066 0.211496228686086 0.752243863025546 mirMAP -0.228981780195079 0.0017229771695853 NA NA NA hsa-miR-548o-3p CACNA2D1 -0.191447572716994 0.517725546183501 0.211496228686086 0.752243863025546 mirMAP -0.539371588606849 0.00018741998967039 NA NA NA hsa-miR-576-5p CACNA2D1 -0.506413219377403 0.417187951364173 0.211496228686086 0.752243863025546 mirMAP -1.18495836149488 2.86804167440462e-15 NA NA NA hsa-miR-590-3p CACNA2D1 -0.279244755376859 0.59126669933662 0.211496228686086 0.752243863025546 mirMAP -1.13841894845436 8.25063409652166e-21 NA NA NA hsa-miR-7-1-3p CACNA2D1 -0.462485777435991 0.665899751398166 0.211496228686086 0.752243863025546 mirMAP -1.18990944684326 3.35826447776923e-16 NA NA NA hsa-miR-96-5p CACNA2D1 0.0854810872029343 0.923087820185031 0.211496228686086 0.752243863025546 TargetScan;miRNATAP -1.0922724347593 7.03068087883141e-18 NA NA NA hsa-miR-18a-3p CACNA2D3 -0.270443061178857 0.535291623032886 0.396221309054374 0.617587739006227 miRNAWalker2_validate -0.298458275889625 0.000267993044937778 NA NA NA hsa-miR-27a-3p CACNA2D3 -0.123902317731458 0.958804393510999 0.396221309054374 0.617587739006227 miRNATAP -0.517422185854335 0.00433913318081683 NA NA NA hsa-miR-361-5p CACNA2D3 -0.138735309928775 0.941495130308343 0.396221309054374 0.617587739006227 miRanda -0.785814142647489 3.5398450278989e-05 NA NA NA hsa-miR-421 CACNA2D3 -0.182032017078616 0.734704500318599 0.396221309054374 0.617587739006227 miRanda -0.377931699396195 0.000465502081331007 NA NA NA hsa-miR-429 CACNA2D3 -0.456485631615963 0.806240953400535 0.396221309054374 0.617587739006227 miRanda -0.492721542484626 1.60276956608453e-08 NA NA NA hsa-miR-590-3p CACNA2D3 -0.279244755376859 0.59126669933662 0.396221309054374 0.617587739006227 miRanda -0.489707146133902 1.18176158329215e-07 NA NA NA hsa-miR-181b-5p CACNB2 0.155313039554487 0.930176779696506 0.00621657739703319 0.988298776694673 miRNATAP -0.278650871750888 0.00815843814858904 NA NA NA hsa-miR-23a-3p CACNB2 -0.122198715333656 0.962717452143511 0.00621657739703319 0.988298776694673 mirMAP -0.683911605085866 2.95012415889249e-05 NA NA NA hsa-miR-27a-3p CACNB2 -0.123902317731458 0.958804393510999 0.00621657739703319 0.988298776694673 MirTarget;miRNATAP -0.37094069756814 0.00950416343085544 NA NA NA hsa-miR-29a-5p CACNB2 -0.31835175571979 0.600442757817281 0.00621657739703319 0.988298776694673 MirTarget -0.280619565440338 0.000539539632365924 NA NA NA hsa-let-7g-3p CACNB4 -0.489638373791485 0.62941522205833 0.44180284609161 0.350161230277014 miRNATAP -0.344386343755015 0.000183246326831145 NA NA NA hsa-miR-155-5p CACNB4 -0.407235807706004 0.828669616718496 0.44180284609161 0.350161230277014 mirMAP;miRNATAP -0.322545608907172 0.00254756691093068 NA NA NA hsa-miR-15a-5p CACNB4 -0.0674049094129128 0.964835434214123 0.44180284609161 0.350161230277014 miRNATAP -0.507403909359909 9.18233604717202e-05 NA NA NA hsa-miR-15b-3p CACNB4 -0.557749208157585 0.609181305423188 0.44180284609161 0.350161230277014 mirMAP -0.499062839125588 5.88307294829171e-06 NA NA NA hsa-miR-15b-5p CACNB4 -0.272614787130877 0.87096541832188 0.44180284609161 0.350161230277014 miRNATAP -0.377449110253513 0.00207673380939566 NA NA NA hsa-miR-16-1-3p CACNB4 0.151694812889216 0.733736501874638 0.44180284609161 0.350161230277014 mirMAP -0.328947718286365 0.000550116651703826 NA NA NA hsa-miR-16-5p CACNB4 0.0135949734723564 0.994476223855607 0.44180284609161 0.350161230277014 miRNATAP -0.426915643468694 0.000458478561680493 NA NA NA hsa-miR-196a-5p CACNB4 -0.0569856738232488 0.973093117800687 0.44180284609161 0.350161230277014 miRNATAP -0.199216888561684 0.00196791432041299 NA NA NA hsa-miR-196b-5p CACNB4 -0.0840912027031901 0.972112413910242 0.44180284609161 0.350161230277014 miRNATAP -0.176580711433577 0.00494464799512866 NA NA NA hsa-miR-20a-3p CACNB4 0.456808229166028 0.57674056136504 0.44180284609161 0.350161230277014 miRNATAP -0.226443600717535 0.00279019108014342 NA NA NA hsa-miR-221-3p CACNB4 0.0906940388127513 0.959121118272534 0.44180284609161 0.350161230277014 miRNATAP -0.499005696410898 0.000176260552427902 NA NA NA hsa-miR-222-3p CACNB4 -0.0265849318772702 0.984005474689108 0.44180284609161 0.350161230277014 miRNATAP -0.547583239952331 3.51008719457231e-06 NA NA NA hsa-miR-25-3p CACNB4 -0.457540448732733 0.878574066837636 0.44180284609161 0.350161230277014 mirMAP -0.615274450156919 4.77042635862097e-05 NA NA NA hsa-miR-26a-2-3p CACNB4 -0.427772454814258 0.28776911697575 0.44180284609161 0.350161230277014 mirMAP -0.295680892656152 0.00253506853981796 NA NA NA hsa-miR-29a-5p CACNB4 -0.31835175571979 0.600442757817281 0.44180284609161 0.350161230277014 mirMAP -0.501263472212982 2.42890771837902e-07 NA NA NA hsa-miR-29b-1-5p CACNB4 -0.642348119412534 0.293891497238796 0.44180284609161 0.350161230277014 mirMAP -0.405825326688339 7.71221035497294e-08 NA NA NA hsa-miR-32-3p CACNB4 -0.568003960723004 0.13133163420273 0.44180284609161 0.350161230277014 mirMAP;miRNATAP -0.275319099619686 0.000426180133316447 NA NA NA hsa-miR-32-5p CACNB4 -0.05993267619119 0.952975951594959 0.44180284609161 0.350161230277014 mirMAP -0.295388635692085 0.00539259112873426 NA NA NA hsa-miR-335-3p CACNB4 -0.244830745789445 0.88450019116631 0.44180284609161 0.350161230277014 mirMAP -0.324330003048107 0.00102128403372536 NA NA NA hsa-miR-338-3p CACNB4 0.49158501750012 0.788483749194189 0.44180284609161 0.350161230277014 PITA;miRanda;miRNATAP -0.302181947223871 0.000163109035448589 NA NA NA hsa-miR-374a-5p CACNB4 -0.343007247142618 0.766921280269271 0.44180284609161 0.350161230277014 mirMAP -0.519468183125037 0.000791688622179696 NA NA NA hsa-miR-421 CACNB4 -0.182032017078616 0.734704500318599 0.44180284609161 0.350161230277014 PITA;miRanda;miRNATAP -0.304976762306444 0.0033317074581931 NA NA NA hsa-miR-429 CACNB4 -0.456485631615963 0.806240953400535 0.44180284609161 0.350161230277014 PITA;miRanda;miRNATAP -0.256659183105202 0.00276121315586847 NA NA NA hsa-miR-505-3p CACNB4 -0.469094267152605 0.690382680489578 0.44180284609161 0.350161230277014 miRNATAP -0.443460484285975 0.000655285315451666 NA NA NA hsa-miR-532-5p CACNB4 -0.349665553500088 0.878948352437467 0.44180284609161 0.350161230277014 miRNATAP -0.469585513591684 1.16167445591452e-05 NA NA NA hsa-miR-550a-3p CACNB4 -0.6199901113685 0.0836206511566976 0.44180284609161 0.350161230277014 miRNATAP -0.375619878619958 2.72699395086245e-05 NA NA NA hsa-miR-577 CACNB4 -1.06238199218774 0.326056761787754 0.44180284609161 0.350161230277014 mirMAP -0.255346939279574 4.40015266562853e-06 NA NA NA hsa-miR-582-3p CACNB4 -0.2334649592375 0.897678119160318 0.44180284609161 0.350161230277014 PITA;miRNATAP -0.392156929570006 0.000525156210813028 NA NA NA hsa-miR-589-3p CACNB4 -0.835836305204965 0.0112001563801511 0.44180284609161 0.350161230277014 mirMAP -0.44475998112089 6.79714155532144e-08 NA NA NA hsa-miR-590-3p CACNB4 -0.279244755376859 0.59126669933662 0.44180284609161 0.350161230277014 miRanda;mirMAP;miRNATAP -0.40475240243865 5.8981735478993e-06 NA NA NA hsa-miR-92a-3p CACNB4 0.0278830870766349 0.993247426671713 0.44180284609161 0.350161230277014 mirMAP -0.313811142750592 0.00498575940671072 NA NA NA hsa-let-7a-5p CACNG4 -0.0620211756550422 0.985006886285188 1.66910865681926 0.0575060227978892 TargetScan -1.16796578116256 0.0064025204154167 NA NA NA hsa-let-7f-1-3p CACNG4 -0.31101436822914 0.693407210545374 1.66910865681926 0.0575060227978892 MirTarget -1.0032213015635 0.00475105817882078 NA NA NA hsa-miR-186-5p CACNG4 -0.318786974828757 0.85412722938961 1.66910865681926 0.0575060227978892 mirMAP -1.20315665237257 0.000244317970546944 NA NA NA hsa-miR-330-3p CACNG4 0.00298687748748416 0.994504006750491 1.66910865681926 0.0575060227978892 mirMAP -0.74737408302427 0.00364508439031876 NA NA NA hsa-miR-375 CACNG4 -0.690952835064582 0.831716365337668 1.66910865681926 0.0575060227978892 miRanda -0.573658842806095 0.00010418999511985 NA NA NA hsa-miR-582-3p CACNG4 -0.2334649592375 0.897678119160318 1.66910865681926 0.0575060227978892 miRNATAP -1.08316749289559 8.00057845897544e-06 NA NA NA hsa-miR-590-3p CACNG4 -0.279244755376859 0.59126669933662 1.66910865681926 0.0575060227978892 miRanda -0.640642017335975 0.00105109109728323 NA NA NA hsa-miR-30a-5p CASP3 0.219472325612346 0.933954023293816 -0.162965782047655 0.903158908366085 miRNATAP -0.203229832372977 5.73122351633379e-05 NA NA NA hsa-miR-335-5p CD14 -0.0284895175847679 0.973380867832231 -0.111969371024372 0.92891722757105 miRNAWalker2_validate -0.564144928539218 3.92858543085243e-16 NA NA NA hsa-miR-143-5p CDC42 0.10589969923845 0.933358732923556 -0.145789682850817 0.93702110357077 miRNATAP -0.116073615725907 2.04088148084208e-05 NA NA NA hsa-miR-23b-3p CHUK -0.10822254818704 0.961352920317636 -0.096549775668116 0.93218060129343 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.136584882734319 0.00997084019729046 NA NA NA hsa-miR-106a-5p CRK -0.203919267842652 0.802213958426804 -0.180113782554166 0.883037386797234 MirTarget;miRNATAP -0.11053463752604 0.00393206932722933 NA NA NA hsa-miR-106b-5p CRK -0.297128724729339 0.869294443540749 -0.180113782554166 0.883037386797234 MirTarget;miRNATAP -0.15359137370457 0.000511174939392179 NA NA NA hsa-miR-125a-5p CRK -0.00183986061615382 0.999158100170883 -0.180113782554166 0.883037386797234 miRNAWalker2_validate -0.14448590290063 0.00417405638762927 NA NA NA hsa-miR-17-5p CRK -0.175448849583061 0.934544015912731 -0.180113782554166 0.883037386797234 MirTarget;TargetScan;miRNATAP -0.119914529830598 0.000366406766038293 NA NA NA hsa-miR-193a-3p CRK -0.247265785363732 0.654363581941634 -0.180113782554166 0.883037386797234 miRanda -0.171888940300891 1.44941054127165e-06 NA NA NA hsa-miR-30c-5p CRK -0.298383882401475 0.865809030482001 -0.180113782554166 0.883037386797234 miRNATAP -0.224350013823638 3.15373124992106e-05 NA NA NA hsa-miR-328-3p CRK -0.27090542057371 0.758001839490036 -0.180113782554166 0.883037386797234 MirTarget -0.142962659045629 0.000777272526902063 NA NA NA hsa-miR-335-3p CRK -0.244830745789445 0.88450019116631 -0.180113782554166 0.883037386797234 mirMAP -0.149307064181051 1.84566278932574e-05 NA NA NA hsa-miR-361-5p CRK -0.138735309928775 0.941495130308343 -0.180113782554166 0.883037386797234 miRanda;mirMAP -0.296765489516061 4.2589363717067e-06 NA NA NA hsa-miR-362-3p CRK -0.721040238345347 0.0345881362485733 -0.180113782554166 0.883037386797234 miRanda -0.120895293527144 0.000106786786970999 NA NA NA hsa-miR-369-3p CRK 0.116576891957687 0.83230082995912 -0.180113782554166 0.883037386797234 MirTarget -0.107387285716647 0.00672703261366595 NA NA NA hsa-miR-374a-5p CRK -0.343007247142618 0.766921280269271 -0.180113782554166 0.883037386797234 mirMAP -0.266227549420494 9.60145584141966e-07 NA NA NA hsa-miR-374b-5p CRK -0.285682091626878 0.83569830479965 -0.180113782554166 0.883037386797234 mirMAP -0.332466090134999 1.23412224639275e-10 NA NA NA hsa-let-7g-5p DUSP1 -0.200947212961157 0.922992045181955 0.224578561244384 0.879993077711205 miRNATAP -0.426083410355233 0.00121740037333471 NA NA NA hsa-miR-101-3p DUSP1 0.0107754887734437 0.997036362636866 0.224578561244384 0.879993077711205 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.355213547026485 0.00474139467361755 NA NA NA hsa-miR-141-3p DUSP1 -0.31994058840327 0.87774106909065 0.224578561244384 0.879993077711205 TargetScan -0.316546111212633 6.86059921544297e-06 NA NA NA hsa-miR-148a-3p DUSP1 -0.101286586375016 0.976980454193186 0.224578561244384 0.879993077711205 miRNATAP -0.33298338887868 0.000101553898942999 NA NA NA hsa-miR-186-5p DUSP1 -0.318786974828757 0.85412722938961 0.224578561244384 0.879993077711205 mirMAP -0.355239252991086 0.00258919757059245 NA NA NA hsa-miR-200b-3p DUSP1 -0.426401948379212 0.863957108574195 0.224578561244384 0.879993077711205 MirTarget;TargetScan -0.41402339897878 2.55932715636944e-07 NA NA NA hsa-miR-200c-3p DUSP1 -0.437282635857873 0.887118598436407 0.224578561244384 0.879993077711205 MirTarget;miRNATAP -0.311622524914853 0.000202958866736727 NA NA NA hsa-miR-26b-5p DUSP1 -0.0245931278499594 0.990377966314923 0.224578561244384 0.879993077711205 miRNAWalker2_validate -0.349106491038521 0.00185936514986997 NA NA NA hsa-miR-425-3p DUSP1 -0.26973743688125 0.719187788473379 0.224578561244384 0.879993077711205 MirTarget -0.341242180516125 0.00015607025258249 NA NA NA hsa-miR-429 DUSP1 -0.456485631615963 0.806240953400535 0.224578561244384 0.879993077711205 MirTarget;PITA;miRanda;miRNATAP -0.323769699316468 6.89230889330306e-07 NA NA NA hsa-miR-194-5p DUSP10 -0.159001168846464 0.959682382557336 0.044068933545462 0.960884827511462 miRNATAP -0.204338697595594 0.000173518020599445 NA NA NA hsa-miR-361-5p DUSP10 -0.138735309928775 0.941495130308343 0.044068933545462 0.960884827511462 miRanda -0.330762560579882 0.00105283333259899 NA NA NA hsa-miR-421 DUSP10 -0.182032017078616 0.734704500318599 0.044068933545462 0.960884827511462 PITA;miRanda;miRNATAP -0.153481504602966 0.00738987065644005 NA NA NA hsa-miR-92a-3p DUSP10 0.0278830870766349 0.993247426671713 0.044068933545462 0.960884827511462 MirTarget;miRNATAP -0.189604909043268 0.00201988009527093 24332650 DUSP10 is responsible for miR-92a induced JNK signalling and cell proliferation pancreatic cancer hsa-let-7a-5p DUSP16 -0.0620211756550422 0.985006886285188 -0.0368288098352805 0.980559737841957 TargetScan;miRNATAP -0.248581609948336 0.00107334025698771 NA NA NA hsa-let-7b-5p DUSP16 -0.228773940533783 0.938952933213741 -0.0368288098352805 0.980559737841957 miRNATAP -0.20217748703126 0.000537467233981313 NA NA NA hsa-let-7e-5p DUSP16 0.211156073215582 0.922335699862928 -0.0368288098352805 0.980559737841957 miRNATAP -0.277251104172663 7.72490948508221e-06 NA NA NA hsa-let-7i-5p DUSP16 -0.200792135853451 0.922018647874073 -0.0368288098352805 0.980559737841957 miRNATAP -0.232515460214317 0.00219039700931998 NA NA NA hsa-miR-130b-5p DUSP3 -0.6472141103776 0.379096015222509 0.141360386308396 0.922859542515939 MirTarget -0.137337223532645 1.00448472585249e-07 NA NA NA hsa-miR-141-3p DUSP3 -0.31994058840327 0.87774106909065 0.141360386308396 0.922859542515939 MirTarget;TargetScan;miRNATAP -0.112509233813105 7.06658157421496e-07 NA NA NA hsa-miR-15a-5p DUSP3 -0.0674049094129128 0.964835434214123 0.141360386308396 0.922859542515939 MirTarget;miRNATAP -0.120347568381725 0.000222366522288904 NA NA NA hsa-miR-182-5p DUSP3 -0.104238497940557 0.973380614062243 0.141360386308396 0.922859542515939 mirMAP -0.104603500798877 1.00645716599561e-05 NA NA NA hsa-miR-186-5p DUSP3 -0.318786974828757 0.85412722938961 0.141360386308396 0.922859542515939 mirMAP -0.159781749950299 2.39000893332791e-05 NA NA NA hsa-miR-197-3p DUSP3 -0.455489147957159 0.794916582095149 0.141360386308396 0.922859542515939 mirMAP -0.111213581604679 0.000152681592332305 NA NA NA hsa-miR-30e-3p DUSP3 -0.220498559176349 0.938660731870214 0.141360386308396 0.922859542515939 mirMAP -0.133917118372748 0.00752774156341672 NA NA NA hsa-miR-484 DUSP3 -0.179977202691249 0.886333755572375 0.141360386308396 0.922859542515939 mirMAP -0.174962422285021 1.4863772211048e-07 NA NA NA hsa-miR-192-3p DUSP4 -0.182835023264086 0.910241598161436 -0.812362875810918 0.426847054527331 mirMAP -0.445041065023012 0.000357924574977446 NA NA NA hsa-miR-193a-3p DUSP4 -0.247265785363732 0.654363581941634 -0.812362875810918 0.426847054527331 mirMAP -0.453262839968444 0.000755167943127979 NA NA NA hsa-miR-199b-5p DUSP4 -0.0396557270992508 0.977172718873203 -0.812362875810918 0.426847054527331 miRanda -0.38909784387608 0.00517351988139042 NA NA NA hsa-miR-452-5p DUSP4 -0.0504626418153507 0.973874641360401 -0.812362875810918 0.426847054527331 mirMAP -0.589637654660067 1.63235104727497e-05 NA NA NA hsa-miR-491-3p DUSP4 -0.513850326596847 0.137836285146052 -0.812362875810918 0.426847054527331 MirTarget -0.356487455781535 0.00307735292061726 NA NA NA hsa-miR-181b-5p DUSP5 0.155313039554487 0.930176779696506 0.743036365655628 0.484405720153565 miRNATAP -0.238265638553654 0.00953759483363837 NA NA NA hsa-miR-25-3p DUSP5 -0.457540448732733 0.878574066837636 0.743036365655628 0.484405720153565 MirTarget;miRNATAP -0.34450374042332 0.00161470439493289 NA NA NA hsa-miR-335-5p DUSP5 -0.0284895175847679 0.973380867832231 0.743036365655628 0.484405720153565 miRNAWalker2_validate -0.205922817140678 0.00385520693271685 NA NA NA hsa-miR-429 DUSP5 -0.456485631615963 0.806240953400535 0.743036365655628 0.484405720153565 miRNATAP -0.21620498798625 0.000412505820722004 NA NA NA hsa-miR-92a-3p DUSP5 0.0278830870766349 0.993247426671713 0.743036365655628 0.484405720153565 MirTarget;miRNATAP -0.381963772860467 1.21081905731393e-06 NA NA NA hsa-miR-19b-3p DUSP7 -0.0268530183621474 0.986656783046572 -0.241526233418462 0.824352067622583 MirTarget -0.112999973484634 0.000680449883704145 NA NA NA hsa-miR-335-5p DUSP7 -0.0284895175847679 0.973380867832231 -0.241526233418462 0.824352067622583 mirMAP -0.111413143236358 0.000266249473114003 NA NA NA hsa-miR-362-5p DUSP7 -0.26647467080141 0.752024885130738 -0.241526233418462 0.824352067622583 mirMAP -0.118220766034801 3.70862596349971e-06 NA NA NA hsa-miR-146a-5p EGFR -0.581292803346906 0.73685134936757 -0.158757048599807 0.889536836433204 miRNAWalker2_validate -0.120342498153531 0.00926534743929207 25242818;22161865;25596948;24895573;25417703;23555954;24839931;21632853 Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;MiR 146a suppresses tumor growth and progression by targeting EGFR pathway and in a p ERK dependent manner in castration resistant prostate cancer; Mechanistic studies revealed that miR-146a repressed the expression of EGFR through binding to its 3'-untranslated region; Our findings suggest that ubiquitous loss of miR-146a is a critical mechanism for overexpression of EGFR in CRPC which is crucial to better understanding the pathogenesis of CRPC;Furthermore the expressions of bax and cleaved-caspase-3 mainly were increased in control and overexpression miR-146a groups however the expression of EGFR was inverse; All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells which was performed by up-regulating miR-146a expression then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways and inhibiting invasion through down-regulating the expression of EGFR;Furthermore western blot showed that miR-146a mimic downregulated EGFR ERK1/2 and stat5 signalings; These effects were less potent compared to that of a siRNA targeting EGFR a known target gene of miR-146a; Moreover miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents;Here we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a; We show that BRCA1 binds to MIR146A promoter and activates transcription which in turn attenuates EGFR expression;In functional experiments miR-146a suppressed cell growth induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines H358 H1650 H1975 HCC827 and H292 miR-146a also inhibited the migratory capacity of these NSCLC cells; On the other hand miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR including both TKIs gefitinib erlotinib and afatinib and a monoclonal antibody cetuximab; Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling;Deregulation of miR 146a expression in a mouse model of pancreatic cancer affecting EGFR signaling; Treatment of PC cells with CDF a novel synthetic compound led to re-expression of miR-146a resulting in the down-regulation of EGFR expression; Further knock-down of miR-146a in AsPC-1 cells led to the up-regulation of EGFR expression and showed increased clonogenic growth; In addition knock-down of EGFR by EGFR siRNA transfection of parental AsPC-1 cells and AsPC-1 cells stably transfected with pre-miR-146a resulted in decreased invasive capacity which was further confirmed by reduced luciferase activity in cells transfected with pMIR-Luc reporter vector containing miR-146a binding site; Collectively these results suggest that the loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling and that re-expression of miR-146a by CDF treatment could be useful in designing personalized strategy for the treatment of human PC;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;progression;;;;;; pancreatic cancer;prostate cancer;breast cancer;liver cancer;breast cancer;lung squamous cell cancer;pancreatic cancer;gastric cancer hsa-miR-148b-5p EGFR -0.236618793990305 0.43925706879726 -0.158757048599807 0.889536836433204 mirMAP -0.146751875727126 0.00334551627619675 NA NA NA hsa-miR-32-3p EGFR -0.568003960723004 0.13133163420273 -0.158757048599807 0.889536836433204 mirMAP -0.127312035684583 0.00126420267436394 NA NA NA hsa-miR-501-5p EGFR -0.834032628506285 0.0582725160418523 -0.158757048599807 0.889536836433204 mirMAP -0.109121341773138 0.00737323655722487 NA NA NA hsa-miR-365a-3p ELK4 0.0797451871548276 0.938758494058574 -0.0894666338426395 0.888858092474321 mirMAP -0.155122173423799 0.00069288165860338 NA NA NA hsa-miR-106a-5p FAS -0.203919267842652 0.802213958426804 -0.347166376396346 0.702810017457386 miRNAWalker2_validate;miRTarBase -0.309397365527179 1.69760652678533e-06 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-361-5p FAS -0.138735309928775 0.941495130308343 -0.347166376396346 0.702810017457386 miRanda -0.421714311791871 0.000155426639121472 NA NA NA hsa-miR-590-5p FAS -0.547819833829572 0.472735645776647 -0.347166376396346 0.702810017457386 miRanda -0.168205409634763 0.00402598857592482 NA NA NA hsa-miR-98-5p FAS -0.168162186023221 0.898802461503524 -0.347166376396346 0.702810017457386 miRNAWalker2_validate -0.378145247947084 2.09454221266366e-05 NA NA NA hsa-miR-452-3p FASLG -0.167134177977311 0.799008246175244 -1.01623663960814 0.0497518030689545 mirMAP -0.300498727144317 0.000506966650214745 NA NA NA hsa-miR-92a-3p FASLG 0.0278830870766349 0.993247426671713 -1.01623663960814 0.0497518030689545 miRNATAP -0.376276337966714 0.00278748481239554 NA NA NA hsa-miR-126-5p FGF1 0.0815213541035824 0.956637332055185 0.817056717165033 0.0360338129925349 mirMAP -0.385963766795316 0.00339122919028115 NA NA NA hsa-miR-1275 FGF1 -0.831342050607648 0.0803795852164229 0.817056717165033 0.0360338129925349 MirTarget -0.234426625474762 0.00025742532980694 NA NA NA hsa-miR-16-1-3p FGF1 0.151694812889216 0.733736501874638 0.817056717165033 0.0360338129925349 mirMAP -0.605586522404409 2.09972410475602e-12 NA NA NA hsa-miR-186-5p FGF1 -0.318786974828757 0.85412722938961 0.817056717165033 0.0360338129925349 mirMAP -1.0155361405459 1.0125599886581e-13 NA NA NA hsa-miR-18a-5p FGF1 -0.498318455303917 0.61264091975585 0.817056717165033 0.0360338129925349 MirTarget -0.60434160371127 3.90449003199202e-18 NA NA NA hsa-miR-18b-5p FGF1 -0.0473300652227538 0.899981261531446 0.817056717165033 0.0360338129925349 MirTarget -0.497414084504357 1.23330693858757e-12 NA NA NA hsa-miR-193a-3p FGF1 -0.247265785363732 0.654363581941634 0.817056717165033 0.0360338129925349 PITA -0.313381826112066 0.00108444554830563 NA NA NA hsa-miR-222-5p FGF1 -0.154611068970282 0.819707762805266 0.817056717165033 0.0360338129925349 MirTarget -0.535437056747217 2.28482793706673e-12 NA NA NA hsa-miR-26b-3p FGF1 -0.363222538866814 0.681115126930068 0.817056717165033 0.0360338129925349 MirTarget -0.734270844592521 3.56140435477727e-13 NA NA NA hsa-miR-29a-5p FGF1 -0.31835175571979 0.600442757817281 0.817056717165033 0.0360338129925349 mirMAP -0.700869123417915 1.6307908971127e-15 NA NA NA hsa-miR-320a FGF1 -0.416546433767628 0.840202138616422 0.817056717165033 0.0360338129925349 miRanda -0.463245151210083 0.000132662825849526 NA NA NA hsa-miR-320b FGF1 -0.23561798088153 0.859222532827992 0.817056717165033 0.0360338129925349 miRanda -0.36919906840847 0.000725718517943916 NA NA NA hsa-miR-361-5p FGF1 -0.138735309928775 0.941495130308343 0.817056717165033 0.0360338129925349 miRanda -0.574545150291662 0.00089792986324362 NA NA NA hsa-miR-374a-3p FGF1 -0.118320910531011 0.958176637009264 0.817056717165033 0.0360338129925349 mirMAP -0.501039740161645 6.25400030648256e-07 NA NA NA hsa-miR-429 FGF1 -0.456485631615963 0.806240953400535 0.817056717165033 0.0360338129925349 miRNATAP -0.672751207199376 2.21205294562789e-19 NA NA NA hsa-miR-484 FGF1 -0.179977202691249 0.886333755572375 0.817056717165033 0.0360338129925349 MirTarget;PITA;miRNATAP -0.854875358873338 2.86755681607907e-12 NA NA NA hsa-miR-532-3p FGF1 -0.496590111092324 0.682889021782543 0.817056717165033 0.0360338129925349 miRNATAP -0.579090993770955 6.93746015430313e-11 NA NA NA hsa-miR-550a-5p FGF1 -0.390865630073894 0.535659273352227 0.817056717165033 0.0360338129925349 MirTarget -0.481202126196725 6.09656439029238e-08 NA NA NA hsa-miR-576-5p FGF1 -0.506413219377403 0.417187951364173 0.817056717165033 0.0360338129925349 PITA;mirMAP -0.746010979431166 1.42643113650642e-14 NA NA NA hsa-miR-590-5p FGF1 -0.547819833829572 0.472735645776647 0.817056717165033 0.0360338129925349 MirTarget;miRanda;miRNATAP -0.763780626727086 3.98618728517647e-20 NA NA NA hsa-miR-625-5p FGF1 -0.690759472145277 0.210306534567564 0.817056717165033 0.0360338129925349 MirTarget -0.489273238427581 1.13468194544974e-11 NA NA NA hsa-miR-629-5p FGF1 -0.385679366494342 0.798536530066869 0.817056717165033 0.0360338129925349 MirTarget -0.496856100338096 7.34270954766289e-08 NA NA NA hsa-miR-7-5p FGF1 0.209645143210379 0.773705612298441 0.817056717165033 0.0360338129925349 miRNAWalker2_validate -0.339779616875168 5.53944074838168e-08 NA NA NA hsa-miR-760 FGF1 -0.669469782471462 0.0773517068284613 0.817056717165033 0.0360338129925349 MirTarget;PITA;miRNATAP -0.303186524946084 1.30784299012347e-05 NA NA NA hsa-miR-10a-5p FGF11 0.0740585720685925 0.983770933356406 -0.0753104644635859 0.828389111628698 mirMAP -0.183447717169761 0.00781424110500811 NA NA NA hsa-miR-335-5p FGF11 -0.0284895175847679 0.973380867832231 -0.0753104644635859 0.828389111628698 miRNAWalker2_validate;mirMAP -0.301314897890468 3.3865427403947e-06 NA NA NA hsa-miR-339-5p FGF11 -0.300425087100667 0.712912847076788 -0.0753104644635859 0.828389111628698 miRanda -0.15266312930966 0.0096720714062192 NA NA NA hsa-miR-532-3p FGF11 -0.496590111092324 0.682889021782543 -0.0753104644635859 0.828389111628698 mirMAP -0.193839089005114 0.00273015557871241 NA NA NA hsa-let-7a-3p FGF12 -0.215598045625677 0.85543299203799 -0.0733567813264719 0.90082041524438 MirTarget -0.31967445902099 0.000591732965496754 NA NA NA hsa-let-7f-1-3p FGF12 -0.31101436822914 0.693407210545374 -0.0733567813264719 0.90082041524438 MirTarget -0.346530348049905 0.00665542231614084 NA NA NA hsa-miR-107 FGF12 -0.0365118169251648 0.988364120226869 -0.0733567813264719 0.90082041524438 miRanda -0.449940214923557 0.00151566453905866 NA NA NA hsa-miR-17-5p FGF12 -0.175448849583061 0.934544015912731 -0.0733567813264719 0.90082041524438 TargetScan -0.312407470418788 1.8707426320976e-05 NA NA NA hsa-miR-197-3p FGF12 -0.455489147957159 0.794916582095149 -0.0733567813264719 0.90082041524438 MirTarget -0.349442074406489 0.000122775742485391 NA NA NA hsa-miR-200b-3p FGF12 -0.426401948379212 0.863957108574195 -0.0733567813264719 0.90082041524438 TargetScan -0.399263932943052 7.91026139011957e-07 NA NA NA hsa-miR-29a-5p FGF12 -0.31835175571979 0.600442757817281 -0.0733567813264719 0.90082041524438 MirTarget -0.419708837882208 2.26602339644268e-08 NA NA NA hsa-miR-32-3p FGF12 -0.568003960723004 0.13133163420273 -0.0733567813264719 0.90082041524438 mirMAP -0.238419633289351 8.17883299774707e-05 NA NA NA hsa-miR-335-3p FGF12 -0.244830745789445 0.88450019116631 -0.0733567813264719 0.90082041524438 MirTarget -0.241577032938532 0.00166504582837203 NA NA NA hsa-miR-33a-3p FGF12 -0.794543849238581 0.0105203072007922 -0.0733567813264719 0.90082041524438 mirMAP -0.28084613962831 7.33431744825372e-05 NA NA NA hsa-miR-362-3p FGF12 -0.721040238345347 0.0345881362485733 -0.0733567813264719 0.90082041524438 miRanda -0.210864640223074 0.00209390425937481 NA NA NA hsa-miR-429 FGF12 -0.456485631615963 0.806240953400535 -0.0733567813264719 0.90082041524438 miRNATAP -0.342286210060465 1.57145983452803e-07 NA NA NA hsa-miR-576-5p FGF12 -0.506413219377403 0.417187951364173 -0.0733567813264719 0.90082041524438 mirMAP -0.341959557719686 4.41549115389718e-05 NA NA NA hsa-miR-590-3p FGF12 -0.279244755376859 0.59126669933662 -0.0733567813264719 0.90082041524438 mirMAP -0.351420488091145 3.56594942426894e-07 NA NA NA hsa-miR-627-5p FGF12 -0.625000196758523 0.0876569242709129 -0.0733567813264719 0.90082041524438 MirTarget -0.248598270695446 1.94113453452336e-05 NA NA NA hsa-let-7a-3p FGF13 -0.215598045625677 0.85543299203799 0.520694054373788 0.23998224203533 MirTarget;miRNATAP -0.413074100574929 0.00107885043966615 NA NA NA hsa-let-7f-1-3p FGF13 -0.31101436822914 0.693407210545374 0.520694054373788 0.23998224203533 MirTarget -0.581948669375274 0.000736238594408478 NA NA NA hsa-let-7g-3p FGF13 -0.489638373791485 0.62941522205833 0.520694054373788 0.23998224203533 miRNATAP -0.33696694896657 0.000531004193754099 NA NA NA hsa-miR-141-3p FGF13 -0.31994058840327 0.87774106909065 0.520694054373788 0.23998224203533 TargetScan -0.417159688034008 1.38167745575151e-05 NA NA NA hsa-miR-142-5p FGF13 -0.118920788314118 0.929665277963083 0.520694054373788 0.23998224203533 PITA -0.292382680960941 0.00456041296807669 NA NA NA hsa-miR-200a-5p FGF13 -0.671005453811576 0.78126028567661 0.520694054373788 0.23998224203533 MirTarget;miRNATAP -0.564495834356228 3.51651879637505e-08 NA NA NA hsa-miR-200b-5p FGF13 -0.502275384207405 0.722255155236927 0.520694054373788 0.23998224203533 MirTarget -0.460602297876751 6.93130489630411e-06 NA NA NA hsa-miR-31-3p FGF13 0.199700996192121 0.762032341762692 0.520694054373788 0.23998224203533 miRNATAP -0.174024666919551 0.000702309408246688 NA NA NA hsa-miR-338-5p FGF13 0.484769112400393 0.393961930708873 0.520694054373788 0.23998224203533 PITA -0.36774029417946 7.03795092005192e-06 NA NA NA hsa-miR-429 FGF13 -0.456485631615963 0.806240953400535 0.520694054373788 0.23998224203533 miRNATAP -0.355487712048412 7.40384400340134e-05 NA NA NA hsa-miR-486-5p FGF13 -0.547739229538641 0.696404149927963 0.520694054373788 0.23998224203533 MirTarget;PITA;miRanda;miRNATAP -0.326993602223932 1.70539866789723e-05 NA NA NA hsa-miR-590-3p FGF13 -0.279244755376859 0.59126669933662 0.520694054373788 0.23998224203533 miRanda -0.459516353830251 9.69022571347246e-07 NA NA NA hsa-miR-7-1-3p FGF13 -0.462485777435991 0.665899751398166 0.520694054373788 0.23998224203533 MirTarget;mirMAP -0.56794497333139 2.1848177002488e-07 NA NA NA hsa-miR-362-3p FGF14 -0.721040238345347 0.0345881362485733 0.374536933825775 0.507146047810317 miRanda -0.430182537519489 0.000218513107489866 NA NA NA hsa-miR-421 FGF14 -0.182032017078616 0.734704500318599 0.374536933825775 0.507146047810317 miRanda -0.563420841003856 3.64961938596398e-05 NA NA NA hsa-miR-590-3p FGF14 -0.279244755376859 0.59126669933662 0.374536933825775 0.507146047810317 miRanda -0.820571422841574 7.63570407372503e-13 NA NA NA hsa-miR-96-5p FGF14 0.0854810872029343 0.923087820185031 0.374536933825775 0.507146047810317 TargetScan -0.651137820954271 6.59629769306502e-08 NA NA NA hsa-miR-107 FGF18 -0.0365118169251648 0.988364120226869 0.513929702717105 0.152144517947723 miRNATAP -0.44685632238394 0.00446346884872776 NA NA NA hsa-miR-15b-5p FGF18 -0.272614787130877 0.87096541832188 0.513929702717105 0.152144517947723 miRNATAP -0.345636147309442 0.00101388588722558 NA NA NA hsa-miR-330-5p FGF18 -0.283418953659271 0.815687101334695 0.513929702717105 0.152144517947723 PITA;miRanda;miRNATAP -0.337702816618645 0.00574604476925169 NA NA NA hsa-miR-590-3p FGF19 -0.279244755376859 0.59126669933662 2.93753615752985 0.000487871953382583 miRanda -0.570350872877377 0.00177520377476347 NA NA NA hsa-let-7a-3p FGF2 -0.215598045625677 0.85543299203799 0.0373403819942291 0.945663156310759 mirMAP -0.508812543963832 9.06476874891136e-06 NA NA NA hsa-let-7f-1-3p FGF2 -0.31101436822914 0.693407210545374 0.0373403819942291 0.945663156310759 mirMAP -0.898041596287031 5.55229359834088e-09 NA NA NA hsa-miR-103a-3p FGF2 -0.0763197091351717 0.980693102700275 0.0373403819942291 0.945663156310759 miRNAWalker2_validate;MirTarget;miRNATAP -0.555487766101954 0.000299387910834376 NA NA NA hsa-miR-107 FGF2 -0.0365118169251648 0.988364120226869 0.0373403819942291 0.945663156310759 MirTarget;PITA;miRanda;miRNATAP -0.666631439624559 0.000145161445434373 NA NA NA hsa-miR-1226-3p FGF2 -0.346825224699346 0.341199987121208 0.0373403819942291 0.945663156310759 MirTarget -0.426739098936905 2.27346551727714e-07 NA NA NA hsa-miR-126-5p FGF2 0.0815213541035824 0.956637332055185 0.0373403819942291 0.945663156310759 mirMAP -0.39861237255362 0.00311441679746807 NA NA NA hsa-miR-144-3p FGF2 0.0482420655617901 0.935871997593533 0.0373403819942291 0.945663156310759 MirTarget -0.185114796915547 0.00371893362650857 NA NA NA hsa-miR-146a-5p FGF2 -0.581292803346906 0.73685134936757 0.0373403819942291 0.945663156310759 mirMAP -0.239303659357824 0.00689738103130393 NA NA NA hsa-miR-148a-5p FGF2 -0.448099743845604 0.748419139652266 0.0373403819942291 0.945663156310759 mirMAP -0.643255342350378 1.37067115832144e-10 NA NA NA hsa-miR-15a-5p FGF2 -0.0674049094129128 0.964835434214123 0.0373403819942291 0.945663156310759 MirTarget;miRNATAP -0.810595460576908 2.34389020257957e-11 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 -0.557749208157585 0.609181305423188 0.0373403819942291 0.945663156310759 mirMAP -0.873695486287884 2.58254499447684e-18 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 -0.272614787130877 0.87096541832188 0.0373403819942291 0.945663156310759 MirTarget;miRNATAP -0.632114726323833 4.74427142629327e-08 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 0.151694812889216 0.733736501874638 0.0373403819942291 0.945663156310759 mirMAP -0.595329456522208 1.85904394592668e-11 NA NA NA hsa-miR-16-2-3p FGF2 -0.36717860153421 0.546850726070016 0.0373403819942291 0.945663156310759 mirMAP -0.676110107115778 1.38872264287738e-13 NA NA NA hsa-miR-16-5p FGF2 0.0135949734723564 0.994476223855607 0.0373403819942291 0.945663156310759 miRNAWalker2_validate;MirTarget;miRNATAP -0.781119741978123 5.08790173078263e-12 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-186-5p FGF2 -0.318786974828757 0.85412722938961 0.0373403819942291 0.945663156310759 miRNAWalker2_validate;mirMAP -1.1396095411898 1.32095654595195e-16 NA NA NA hsa-miR-192-5p FGF2 -0.117345487848223 0.972927287653137 0.0373403819942291 0.945663156310759 miRNAWalker2_validate -0.660983463822095 1.1746446867625e-17 NA NA NA hsa-miR-19b-1-5p FGF2 -0.0105982583216702 0.988511655226679 0.0373403819942291 0.945663156310759 mirMAP -0.6699845320046 3.36056715432067e-13 NA NA NA hsa-miR-200b-3p FGF2 -0.426401948379212 0.863957108574195 0.0373403819942291 0.945663156310759 mirMAP -0.764037256793823 2.14808621340383e-15 NA NA NA hsa-miR-200c-3p FGF2 -0.437282635857873 0.887118598436407 0.0373403819942291 0.945663156310759 mirMAP -0.707152104708369 2.07242913334904e-12 NA NA NA hsa-miR-20a-3p FGF2 0.456808229166028 0.57674056136504 0.0373403819942291 0.945663156310759 mirMAP -0.565021759285698 1.65191743671975e-16 NA NA NA hsa-miR-21-3p FGF2 -0.395016549347053 0.87819982773565 0.0373403819942291 0.945663156310759 mirMAP -0.525887720334036 2.03384873578629e-05 NA NA NA hsa-miR-215-5p FGF2 -0.142648109361913 0.94480931294964 0.0373403819942291 0.945663156310759 miRNAWalker2_validate -0.1996191442956 0.000148824005851472 NA NA NA hsa-miR-221-3p FGF2 0.0906940388127513 0.959121118272534 0.0373403819942291 0.945663156310759 mirMAP -0.511851720649979 6.5981563407402e-05 NA NA NA hsa-miR-222-3p FGF2 -0.0265849318772702 0.984005474689108 0.0373403819942291 0.945663156310759 mirMAP -0.553734986991286 1.13582430859507e-06 NA NA NA hsa-miR-29a-5p FGF2 -0.31835175571979 0.600442757817281 0.0373403819942291 0.945663156310759 mirMAP -0.742375002118135 1.13325741058218e-16 NA NA NA hsa-miR-32-5p FGF2 -0.05993267619119 0.952975951594959 0.0373403819942291 0.945663156310759 miRNAWalker2_validate -0.754687420738596 5.83016327813086e-15 NA NA NA hsa-miR-335-3p FGF2 -0.244830745789445 0.88450019116631 0.0373403819942291 0.945663156310759 mirMAP -0.623112924854523 1.0815869667606e-11 NA NA NA hsa-miR-335-5p FGF2 -0.0284895175847679 0.973380867832231 0.0373403819942291 0.945663156310759 miRNATAP -0.536967962946236 9.06296636807829e-09 NA NA NA hsa-miR-361-5p FGF2 -0.138735309928775 0.941495130308343 0.0373403819942291 0.945663156310759 mirMAP -0.78695237917696 7.1578087398883e-06 NA NA NA hsa-miR-374a-3p FGF2 -0.118320910531011 0.958176637009264 0.0373403819942291 0.945663156310759 mirMAP -0.405589678990389 9.7090927181742e-05 NA NA NA hsa-miR-374a-5p FGF2 -0.343007247142618 0.766921280269271 0.0373403819942291 0.945663156310759 mirMAP -0.615897614224652 3.39071246093852e-05 NA NA NA hsa-miR-374b-5p FGF2 -0.285682091626878 0.83569830479965 0.0373403819942291 0.945663156310759 mirMAP -0.63693950869037 9.22970111909352e-06 NA NA NA hsa-miR-424-5p FGF2 0.247080963500746 0.870154571783568 0.0373403819942291 0.945663156310759 MirTarget;miRNATAP -0.317186554824623 0.000274243410436879 NA NA NA hsa-miR-429 FGF2 -0.456485631615963 0.806240953400535 0.0373403819942291 0.945663156310759 mirMAP -0.659250932855199 1.3145598381986e-17 NA NA NA hsa-miR-450b-5p FGF2 -0.0136687538973108 0.983149761399849 0.0373403819942291 0.945663156310759 mirMAP -0.376394927184003 0.000544626699489289 NA NA NA hsa-miR-452-5p FGF2 -0.0504626418153507 0.973874641360401 0.0373403819942291 0.945663156310759 mirMAP -0.316774722550962 0.00166338629734726 NA NA NA hsa-miR-503-5p FGF2 0.181411121123657 0.766398160421164 0.0373403819942291 0.945663156310759 miRNAWalker2_validate -0.242112168267636 0.00115555825657166 NA NA NA hsa-miR-548o-3p FGF2 -0.191447572716994 0.517725546183501 0.0373403819942291 0.945663156310759 mirMAP -0.405276201885792 1.87951720405162e-05 NA NA NA hsa-miR-577 FGF2 -1.06238199218774 0.326056761787754 0.0373403819942291 0.945663156310759 mirMAP -0.418499733893086 2.48828015960997e-16 NA NA NA hsa-miR-589-3p FGF2 -0.835836305204965 0.0112001563801511 0.0373403819942291 0.945663156310759 mirMAP -0.469403508103215 2.93831023020729e-09 NA NA NA hsa-miR-590-3p FGF2 -0.279244755376859 0.59126669933662 0.0373403819942291 0.945663156310759 miRanda;mirMAP -0.580439028713546 4.11374953518771e-12 NA NA NA hsa-miR-590-5p FGF2 -0.547819833829572 0.472735645776647 0.0373403819942291 0.945663156310759 miRanda;mirMAP -0.776292987315148 8.39227453533076e-20 NA NA NA hsa-miR-92a-3p FGF2 0.0278830870766349 0.993247426671713 0.0373403819942291 0.945663156310759 miRNAWalker2_validate -0.727257700170323 1.67908806653227e-12 NA NA NA hsa-miR-93-3p FGF2 -0.438355548962673 0.549902689385444 0.0373403819942291 0.945663156310759 mirMAP -0.765339743128867 1.06748038330992e-15 NA NA NA hsa-let-7a-3p FGF7 -0.215598045625677 0.85543299203799 0.117105484614997 0.84810083077581 MirTarget;miRNATAP -0.683797140192053 9.84850919759302e-09 NA NA NA hsa-let-7f-1-3p FGF7 -0.31101436822914 0.693407210545374 0.117105484614997 0.84810083077581 MirTarget -1.01161889577803 3.96642337308699e-10 NA NA NA hsa-miR-107 FGF7 -0.0365118169251648 0.988364120226869 0.117105484614997 0.84810083077581 PITA;miRanda;miRNATAP -0.735310081307788 7.03519067269405e-05 NA NA NA hsa-miR-15a-5p FGF7 -0.0674049094129128 0.964835434214123 0.117105484614997 0.84810083077581 miRTarBase;miRNATAP -0.915215726654164 5.87256834931938e-13 NA NA NA hsa-miR-15b-5p FGF7 -0.272614787130877 0.87096541832188 0.117105484614997 0.84810083077581 miRNATAP -0.898118902123496 3.56849030030929e-14 NA NA NA hsa-miR-16-1-3p FGF7 0.151694812889216 0.733736501874638 0.117105484614997 0.84810083077581 mirMAP -0.658002745075143 1.56217551778173e-12 NA NA NA hsa-miR-16-2-3p FGF7 -0.36717860153421 0.546850726070016 0.117105484614997 0.84810083077581 mirMAP -0.841611831563134 3.02322699081552e-19 NA NA NA hsa-miR-16-5p FGF7 0.0135949734723564 0.994476223855607 0.117105484614997 0.84810083077581 miRNATAP -0.996043180010876 9.83296454189259e-18 NA NA NA hsa-miR-18a-3p FGF7 -0.270443061178857 0.535291623032886 0.117105484614997 0.84810083077581 MirTarget -0.452090132240855 7.63312718888582e-09 NA NA NA hsa-miR-192-3p FGF7 -0.182835023264086 0.910241598161436 0.117105484614997 0.84810083077581 mirMAP -0.730591279287558 7.23835865583408e-16 NA NA NA hsa-miR-20a-5p FGF7 -0.179153323927949 0.928118119139752 0.117105484614997 0.84810083077581 miRNAWalker2_validate -0.671805814937027 1.227742024366e-13 NA NA NA hsa-miR-26b-5p FGF7 -0.0245931278499594 0.990377966314923 0.117105484614997 0.84810083077581 mirMAP -0.994759587889311 1.98671841899925e-12 NA NA NA hsa-miR-27a-3p FGF7 -0.123902317731458 0.958804393510999 0.117105484614997 0.84810083077581 MirTarget -0.79784830342047 5.00354716971529e-06 NA NA NA hsa-miR-30d-3p FGF7 -0.123474741320298 0.814905367625791 0.117105484614997 0.84810083077581 miRNATAP -0.848677643180664 4.97187104853254e-13 NA NA NA hsa-miR-31-5p FGF7 0.554749187802405 0.452741448126019 0.117105484614997 0.84810083077581 MirTarget -0.12713264127766 0.00816156313575643 NA NA NA hsa-miR-320a FGF7 -0.416546433767628 0.840202138616422 0.117105484614997 0.84810083077581 miRanda -0.38477547966865 0.00354239940076227 NA NA NA hsa-miR-33a-3p FGF7 -0.794543849238581 0.0105203072007922 0.117105484614997 0.84810083077581 mirMAP -0.569137001117195 3.2142782858291e-10 NA NA NA hsa-miR-361-5p FGF7 -0.138735309928775 0.941495130308343 0.117105484614997 0.84810083077581 PITA;miRanda;miRNATAP -0.817249024356749 1.02535422069167e-05 NA NA NA hsa-miR-374a-3p FGF7 -0.118320910531011 0.958176637009264 0.117105484614997 0.84810083077581 miRNATAP -0.461888146139023 2.48354867802797e-05 NA NA NA hsa-miR-376b-3p FGF7 -0.00712550627858333 0.982426403308526 0.117105484614997 0.84810083077581 mirMAP -0.25669480427003 0.00740387863393709 NA NA NA hsa-miR-421 FGF7 -0.182032017078616 0.734704500318599 0.117105484614997 0.84810083077581 miRanda -0.482726608710923 3.82945596931546e-06 NA NA NA hsa-miR-424-5p FGF7 0.247080963500746 0.870154571783568 0.117105484614997 0.84810083077581 miRNATAP -0.323271584602368 0.000450740900959982 NA NA NA hsa-miR-429 FGF7 -0.456485631615963 0.806240953400535 0.117105484614997 0.84810083077581 miRNATAP -0.774285251391027 2.36438990639667e-22 NA NA NA hsa-miR-455-3p FGF7 -0.356341681711462 0.824635754440661 0.117105484614997 0.84810083077581 PITA;miRNATAP -0.48338226161898 1.06435583592578e-07 NA NA NA hsa-miR-484 FGF7 -0.179977202691249 0.886333755572375 0.117105484614997 0.84810083077581 PITA -0.782625541153355 5.9522288202395e-09 NA NA NA hsa-miR-501-5p FGF7 -0.834032628506285 0.0582725160418523 0.117105484614997 0.84810083077581 PITA;mirMAP -0.341715472671014 2.71246634460809e-05 NA NA NA hsa-miR-577 FGF7 -1.06238199218774 0.326056761787754 0.117105484614997 0.84810083077581 PITA;mirMAP -0.491874797413476 1.17833120646792e-20 NA NA NA hsa-miR-582-3p FGF7 -0.2334649592375 0.897678119160318 0.117105484614997 0.84810083077581 PITA;miRNATAP -0.603474572580205 9.9286156151158e-08 NA NA NA hsa-miR-590-3p FGF7 -0.279244755376859 0.59126669933662 0.117105484614997 0.84810083077581 PITA;miRanda;mirMAP;miRNATAP -0.749830093913929 2.12386794213734e-18 NA NA NA hsa-miR-590-5p FGF7 -0.547819833829572 0.472735645776647 0.117105484614997 0.84810083077581 PITA;miRanda -0.83329719340048 1.49190340527621e-20 NA NA NA hsa-miR-7-1-3p FGF7 -0.462485777435991 0.665899751398166 0.117105484614997 0.84810083077581 mirMAP -0.8693351687903 5.61446758918235e-18 NA NA NA hsa-miR-16-2-3p FGF9 -0.36717860153421 0.546850726070016 1.14029297978378 0.0641126010099636 mirMAP -0.393378730749977 0.00280520232673893 NA NA NA hsa-miR-32-3p FGF9 -0.568003960723004 0.13133163420273 1.14029297978378 0.0641126010099636 mirMAP -0.350559608669684 0.000700563991493217 NA NA NA hsa-miR-369-3p FGF9 0.116576891957687 0.83230082995912 1.14029297978378 0.0641126010099636 mirMAP;miRNATAP -0.385648033163106 0.00880290404065266 NA NA NA hsa-miR-582-5p FGF9 -0.399450205475138 0.581227478860085 1.14029297978378 0.0641126010099636 miRNATAP -0.404187233255667 0.00944896090587376 NA NA NA hsa-miR-590-3p FGF9 -0.279244755376859 0.59126669933662 1.14029297978378 0.0641126010099636 miRanda;mirMAP -0.395821562370221 0.000917959517750086 NA NA NA hsa-miR-590-5p FGF9 -0.547819833829572 0.472735645776647 1.14029297978378 0.0641126010099636 miRanda -0.412960170102671 0.00107892101454606 NA NA NA hsa-miR-106a-5p FGFR1 -0.203919267842652 0.802213958426804 0.201596157808259 0.858976102109112 mirMAP -0.541320037319434 1.27089321486615e-11 NA NA NA hsa-miR-106b-5p FGFR1 -0.297128724729339 0.869294443540749 0.201596157808259 0.858976102109112 mirMAP -0.822036581006192 1.74218158243198e-20 NA NA NA hsa-miR-10a-5p FGFR1 0.0740585720685925 0.983770933356406 0.201596157808259 0.858976102109112 miRNAWalker2_validate -0.427574241021871 5.41836198534693e-08 21738581 Predicted target mRNAs FGFR1 miR-10 and MLH1 miR-155 were found downregulated pancreatic cancer hsa-miR-1262 FGFR1 -0.110067426706709 0.702946442225154 0.201596157808259 0.858976102109112 miRNATAP -0.251289067000032 0.00148412321886111 NA NA NA hsa-miR-135b-5p FGFR1 0.631573976263484 0.610028066417462 0.201596157808259 0.858976102109112 mirMAP -0.282955130702862 1.46105054047634e-08 NA NA NA hsa-miR-15a-5p FGFR1 -0.0674049094129128 0.964835434214123 0.201596157808259 0.858976102109112 miRNATAP -0.697884650841183 4.50635824486199e-13 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGFR1 -0.272614787130877 0.87096541832188 0.201596157808259 0.858976102109112 miRNATAP -0.587016769958609 1.49522035399957e-10 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 0.0135949734723564 0.994476223855607 0.201596157808259 0.858976102109112 miRTarBase;miRNATAP -0.710035294277253 1.6547310603001e-15 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 -0.175448849583061 0.934544015912731 0.201596157808259 0.858976102109112 mirMAP -0.610985080987738 2.23569876237106e-19 NA NA NA hsa-miR-200a-5p FGFR1 -0.671005453811576 0.78126028567661 0.201596157808259 0.858976102109112 mirMAP -0.556564764968645 2.34312674404821e-14 NA NA NA hsa-miR-200b-5p FGFR1 -0.502275384207405 0.722255155236927 0.201596157808259 0.858976102109112 mirMAP -0.636495015609043 1.43412507645059e-19 NA NA NA hsa-miR-20a-5p FGFR1 -0.179153323927949 0.928118119139752 0.201596157808259 0.858976102109112 mirMAP -0.548264098344271 7.83526634355048e-16 NA NA NA hsa-miR-301a-3p FGFR1 -0.105312511901769 0.831686745977347 0.201596157808259 0.858976102109112 mirMAP -0.315204588952987 1.26823479410232e-05 NA NA NA hsa-miR-335-3p FGFR1 -0.244830745789445 0.88450019116631 0.201596157808259 0.858976102109112 mirMAP -0.575295661556483 1.48474905901463e-15 NA NA NA hsa-miR-361-5p FGFR1 -0.138735309928775 0.941495130308343 0.201596157808259 0.858976102109112 miRanda -0.700504879479453 5.36006547735018e-07 NA NA NA hsa-miR-424-5p FGFR1 0.247080963500746 0.870154571783568 0.201596157808259 0.858976102109112 miRNAWalker2_validate;miRTarBase;miRNATAP -0.209822150049386 0.00280762955990033 NA NA NA hsa-miR-532-5p FGFR1 -0.349665553500088 0.878948352437467 0.201596157808259 0.858976102109112 PITA -0.594965040936966 7.97089485362319e-14 NA NA NA hsa-miR-548o-3p FGFR1 -0.191447572716994 0.517725546183501 0.201596157808259 0.858976102109112 mirMAP -0.315700053957701 3.27962049891296e-05 NA NA NA hsa-miR-577 FGFR1 -1.06238199218774 0.326056761787754 0.201596157808259 0.858976102109112 PITA;mirMAP -0.325574779163253 2.46595601408019e-15 NA NA NA hsa-miR-590-3p FGFR1 -0.279244755376859 0.59126669933662 0.201596157808259 0.858976102109112 miRanda;mirMAP -0.519217394538685 4.04575525965042e-15 NA NA NA hsa-miR-93-5p FGFR1 -0.611073677204699 0.825297877093193 0.201596157808259 0.858976102109112 mirMAP -0.666292245954266 1.03850684119196e-14 NA NA NA hsa-miR-188-5p FGFR2 -0.568517670542551 0.324820848307954 -0.37581671975967 0.688774968722175 PITA -0.411925402857108 4.09722691497335e-06 NA NA NA hsa-miR-19b-1-5p FGFR2 -0.0105982583216702 0.988511655226679 -0.37581671975967 0.688774968722175 miRNAWalker2_validate;miRTarBase -0.474383008962662 2.29712590167021e-05 NA NA NA hsa-miR-369-3p FGFR2 0.116576891957687 0.83230082995912 -0.37581671975967 0.688774968722175 miRNATAP -0.32556688552856 0.00975076567041639 NA NA NA hsa-miR-542-3p FGFR2 0.188168046511374 0.909252939431573 -0.37581671975967 0.688774968722175 miRanda -0.720387475259984 9.01022691363113e-07 NA NA NA hsa-miR-940 FGFR2 -0.225788347550697 0.680055767105815 -0.37581671975967 0.688774968722175 miRNATAP -0.270065978012755 0.00207802989445929 NA NA NA hsa-miR-16-5p FLNA 0.0135949734723564 0.994476223855607 0.161950943371258 0.938976778202491 miRNAWalker2_validate -0.817794378454868 5.98607459272521e-21 NA NA NA hsa-miR-196a-5p FLNA -0.0569856738232488 0.973093117800687 0.161950943371258 0.938976778202491 miRNAWalker2_validate -0.321426680384606 2.32286865566633e-11 NA NA NA hsa-miR-200c-3p FLNA -0.437282635857873 0.887118598436407 0.161950943371258 0.938976778202491 miRNAWalker2_validate -0.784431204146435 6.52995377191727e-25 NA NA NA hsa-miR-20a-5p FLNA -0.179153323927949 0.928118119139752 0.161950943371258 0.938976778202491 miRNAWalker2_validate -0.548305844813313 1.00516223775211e-15 NA NA NA hsa-miR-221-3p FLNA 0.0906940388127513 0.959121118272534 0.161950943371258 0.938976778202491 miRNAWalker2_validate -0.506704534547781 7.0534212548053e-07 24443580 In addition the oPD thyroid carcinomas demonstrated upregulation of miR-221 and miR-885-5p thyroid cancer hsa-miR-222-3p FLNA -0.0265849318772702 0.984005474689108 0.161950943371258 0.938976778202491 miRNAWalker2_validate -0.495439269968303 5.01914444988374e-08 NA NA NA hsa-miR-23a-3p FLNA -0.122198715333656 0.962717452143511 0.161950943371258 0.938976778202491 miRNAWalker2_validate -0.55744453753011 0.00034214530032479 NA NA NA hsa-miR-324-5p FLNA -0.50063248413014 0.537416710557032 0.161950943371258 0.938976778202491 miRNAWalker2_validate -0.428401520610537 9.27253498085528e-07 NA NA NA hsa-miR-331-3p FLNA -0.40204226129616 0.670588911553669 0.161950943371258 0.938976778202491 miRNAWalker2_validate -0.393584900599178 1.11373915775401e-05 NA NA NA hsa-miR-378a-3p FLNA -0.466787210598086 0.795055970353024 0.161950943371258 0.938976778202491 miRNAWalker2_validate -0.679696211423532 1.38061432884737e-14 NA NA NA hsa-miR-484 FLNA -0.179977202691249 0.886333755572375 0.161950943371258 0.938976778202491 miRNAWalker2_validate -0.686747366758611 1.08578114025388e-11 NA NA NA hsa-miR-7-5p FLNA 0.209645143210379 0.773705612298441 0.161950943371258 0.938976778202491 miRNAWalker2_validate -0.249436700278254 1.51205758070571e-06 NA NA NA hsa-miR-92a-3p FLNA 0.0278830870766349 0.993247426671713 0.161950943371258 0.938976778202491 miRNAWalker2_validate -0.7022713363805 2.75719420613894e-18 NA NA NA hsa-miR-421 FLNB -0.182032017078616 0.734704500318599 -0.262392655369439 0.896948182953955 mirMAP -0.127503917653684 0.00251974531275411 NA NA NA hsa-miR-92a-3p FLNB 0.0278830870766349 0.993247426671713 -0.262392655369439 0.896948182953955 miRNAWalker2_validate -0.129220352023219 0.00443649710299858 NA NA NA hsa-miR-142-3p FLNC -0.154235241441331 0.946098054588918 0.56652324299774 0.642755098576131 miRanda -0.28849366358437 0.00355160633928824 NA NA NA hsa-miR-19a-3p FLNC -0.206793507801887 0.844637784802316 0.56652324299774 0.642755098576131 miRNATAP -0.714634136613475 7.20433854403193e-14 NA NA NA hsa-miR-19b-3p FLNC -0.0268530183621474 0.986656783046572 0.56652324299774 0.642755098576131 miRNATAP -0.880543799097164 9.71931181141838e-15 NA NA NA hsa-miR-454-3p FLNC -0.101514866328011 0.843545158256191 0.56652324299774 0.642755098576131 miRNAWalker2_validate -0.952248820971119 6.1385489757168e-12 NA NA NA hsa-miR-592 FLNC -0.177670083168544 0.856226890424691 0.56652324299774 0.642755098576131 mirMAP -0.384461624687548 9.40661502537851e-16 NA NA NA hsa-miR-181c-5p FOS 0.042951891660695 0.969159991881861 -0.301895037423915 0.868731274147149 miRNATAP -0.315671110948794 0.00352607811233668 NA NA NA hsa-miR-324-3p GADD45B -0.424387380347173 0.661528309116338 0.524578686880012 0.613526698742649 MirTarget;miRNATAP -0.215175591383005 0.00285407658213762 NA NA NA hsa-miR-590-3p GADD45B -0.279244755376859 0.59126669933662 0.524578686880012 0.613526698742649 miRanda -0.228270935470796 2.64404491951025e-06 NA NA NA hsa-miR-130b-5p GNA12 -0.6472141103776 0.379096015222509 0.0904295182476265 0.947318496332279 mirMAP -0.123161833429754 1.45150492428693e-06 NA NA NA hsa-miR-141-3p GNA12 -0.31994058840327 0.87774106909065 0.0904295182476265 0.947318496332279 mirMAP -0.130114521274731 3.98554720765472e-09 NA NA NA hsa-miR-15b-5p GNA12 -0.272614787130877 0.87096541832188 0.0904295182476265 0.947318496332279 MirTarget -0.103182219795212 0.000641143550086597 NA NA NA hsa-miR-186-5p GNA12 -0.318786974828757 0.85412722938961 0.0904295182476265 0.947318496332279 mirMAP -0.157180572556678 2.4830078736285e-05 NA NA NA hsa-miR-200a-3p GNA12 -0.367034437440907 0.851059894150266 0.0904295182476265 0.947318496332279 mirMAP -0.114687577803665 1.241859640174e-07 NA NA NA hsa-miR-30e-3p GNA12 -0.220498559176349 0.938660731870214 0.0904295182476265 0.947318496332279 MirTarget -0.180916984650545 0.000224149785355508 NA NA NA hsa-miR-93-5p GNA12 -0.611073677204699 0.825297877093193 0.0904295182476265 0.947318496332279 miRNAWalker2_validate -0.105716643751729 0.000261031576503282 NA NA NA hsa-miR-126-5p GNG12 0.0815213541035824 0.956637332055185 -0.142668426794612 0.929391620324368 mirMAP -0.185177316145845 0.000122141017476559 NA NA NA hsa-miR-409-5p GNG12 0.114137352474602 0.862758126973031 -0.142668426794612 0.929391620324368 PITA -0.110560226623452 0.000614581063746225 NA NA NA hsa-miR-455-5p GNG12 -0.139599153671262 0.865744220236311 -0.142668426794612 0.929391620324368 miRanda -0.123706173617567 0.00119377079445104 NA NA NA hsa-miR-10b-5p HSPA1B -0.00612900738307331 0.99856586228788 0.248552248465479 0.88051972333967 miRNAWalker2_validate -0.21164913620244 0.00292974892865749 NA NA NA hsa-miR-192-5p HSPA2 -0.117345487848223 0.972927287653137 0.132564309242557 0.892632300175254 miRNAWalker2_validate -0.341351451837198 4.27474717462053e-07 NA NA NA hsa-miR-215-5p HSPA2 -0.142648109361913 0.94480931294964 0.132564309242557 0.892632300175254 miRNAWalker2_validate -0.122128563774004 0.00547542403419624 NA NA NA hsa-miR-339-5p HSPA2 -0.300425087100667 0.712912847076788 0.132564309242557 0.892632300175254 miRanda -0.213255824145054 0.00274339715991458 NA NA NA hsa-miR-500a-3p HSPA2 -0.633375813338735 0.732582832733155 0.132564309242557 0.892632300175254 miRNATAP -0.296914697317742 0.000653372649497941 NA NA NA hsa-miR-7-1-3p HSPA2 -0.462485777435991 0.665899751398166 0.132564309242557 0.892632300175254 mirMAP -0.291898553566471 0.000568238535656373 NA NA NA hsa-miR-96-5p HSPA2 0.0854810872029343 0.923087820185031 0.132564309242557 0.892632300175254 TargetScan -0.239987713898943 0.00125294652962217 NA NA NA hsa-miR-199a-5p HSPA8 0.157247797504494 0.935797462797012 -0.241169599076219 0.920788584008962 miRanda -0.112128007956542 0.00865468982846036 NA NA NA hsa-miR-199b-5p HSPA8 -0.0396557270992508 0.977172718873203 -0.241169599076219 0.920788584008962 miRanda -0.11253812294841 0.00242454341137972 NA NA NA hsa-miR-26a-5p HSPA8 0.00698202897993028 0.997719986197021 -0.241169599076219 0.920788584008962 miRNAWalker2_validate -0.371447143047408 3.86812309514306e-07 NA NA NA hsa-miR-130b-5p IL1R1 -0.6472141103776 0.379096015222509 0.0971978498625941 0.931380268505521 mirMAP -0.597849986911064 5.11784999134223e-16 NA NA NA hsa-miR-17-3p IL1R1 0.100221625453134 0.960113387014848 0.0971978498625941 0.931380268505521 mirMAP -0.54511908545044 5.99236041868129e-12 NA NA NA hsa-miR-186-5p IL1R1 -0.318786974828757 0.85412722938961 0.0971978498625941 0.931380268505521 mirMAP -0.76373595274815 2.23069407996303e-12 NA NA NA hsa-miR-192-5p IL1R1 -0.117345487848223 0.972927287653137 0.0971978498625941 0.931380268505521 miRNAWalker2_validate -0.521064610824822 2.08223348177442e-18 NA NA NA hsa-miR-197-3p IL1R1 -0.455489147957159 0.794916582095149 0.0971978498625941 0.931380268505521 miRNAWalker2_validate -0.449558594621509 1.86929045400014e-07 NA NA NA hsa-miR-215-5p IL1R1 -0.142648109361913 0.94480931294964 0.0971978498625941 0.931380268505521 miRNAWalker2_validate -0.126995092092766 0.00191347086429665 NA NA NA hsa-miR-24-3p IL1R1 -0.0484778924256624 0.985274054814493 0.0971978498625941 0.931380268505521 miRNATAP -0.603457361426173 0.000199088441297218 NA NA NA hsa-miR-26b-5p IL1R1 -0.0245931278499594 0.990377966314923 0.0971978498625941 0.931380268505521 mirMAP -0.726194062963501 2.40186470051492e-12 NA NA NA hsa-miR-30d-3p IL1R1 -0.123474741320298 0.814905367625791 0.0971978498625941 0.931380268505521 mirMAP -0.633771957362426 1.5127976345712e-13 NA NA NA hsa-miR-335-3p IL1R1 -0.244830745789445 0.88450019116631 0.0971978498625941 0.931380268505521 mirMAP -0.54040951986299 1.03169031216036e-14 NA NA NA hsa-miR-361-5p IL1R1 -0.138735309928775 0.941495130308343 0.0971978498625941 0.931380268505521 miRanda -0.657872921900768 1.10573544927298e-06 NA NA NA hsa-miR-491-5p IL1R1 -0.585652105321328 0.0452620602586908 0.0971978498625941 0.931380268505521 miRanda -0.217319722631291 0.00269495220336367 NA NA NA hsa-miR-548o-3p IL1R1 -0.191447572716994 0.517725546183501 0.0971978498625941 0.931380268505521 mirMAP -0.315827960543417 1.61184818710973e-05 NA NA NA hsa-miR-590-3p IL1R1 -0.279244755376859 0.59126669933662 0.0971978498625941 0.931380268505521 miRanda;miRNATAP -0.491268245890511 1.60582758504113e-14 NA NA NA hsa-miR-126-5p KRAS 0.0815213541035824 0.956637332055185 0.0789064765134055 0.953888724941783 MirTarget -0.119864203753635 0.00133135323525602 22845403 miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK pancreatic cancer hsa-miR-1271-5p KRAS -0.464440824492835 0.095633275297856 0.0789064765134055 0.953888724941783 MirTarget -0.107229521880363 7.56803548098355e-05 NA NA NA hsa-miR-181c-5p KRAS 0.042951891660695 0.969159991881861 0.0789064765134055 0.953888724941783 miRNAWalker2_validate;miRTarBase -0.100747847809848 0.000902565483936579 NA NA NA hsa-miR-199a-5p KRAS 0.157247797504494 0.935797462797012 0.0789064765134055 0.953888724941783 miRanda;miRNATAP -0.106963175847596 0.000895280762960813 NA NA NA hsa-miR-199b-5p KRAS -0.0396557270992508 0.977172718873203 0.0789064765134055 0.953888724941783 miRanda;miRNATAP -0.108743582994301 9.84561646476932e-05 27517624 The miR-199b prognostic impact was particularly evident in both younger and KRAS wild-type subgroups colorectal cancer hsa-miR-30e-5p KRAS -0.0657075181381011 0.979684509181941 0.0789064765134055 0.953888724941783 mirMAP;miRNATAP -0.119414065684219 0.00856624973196858 NA NA NA hsa-miR-101-3p MAP2K1 0.0107754887734437 0.997036362636866 -0.0827143668416932 0.951976704641412 miRNAWalker2_validate -0.184567516398963 1.51165586105245e-05 NA NA NA hsa-miR-34c-5p MAP2K1 -0.018707656771723 0.952788306178575 -0.0827143668416932 0.951976704641412 PITA;miRanda -0.110947114920215 0.000102476815991688 NA NA NA hsa-miR-497-5p MAP2K1 -0.0120217191428731 0.989147225742026 -0.0827143668416932 0.951976704641412 miRNAWalker2_validate -0.154029164580327 9.63370868318467e-06 NA NA NA hsa-miR-374b-5p MAP2K4 -0.285682091626878 0.83569830479965 -0.195336324226513 0.857228924341565 miRNATAP -0.174777895191713 0.00144152254407078 NA NA NA hsa-miR-452-3p MAP2K4 -0.167134177977311 0.799008246175244 -0.195336324226513 0.857228924341565 mirMAP -0.1140767203975 4.16741588696771e-05 NA NA NA hsa-miR-532-3p MAP2K4 -0.496590111092324 0.682889021782543 -0.195336324226513 0.857228924341565 miRNATAP -0.111625947892597 0.00172915886345619 NA NA NA hsa-miR-106a-5p MAP3K12 -0.203919267842652 0.802213958426804 0.289698497751255 0.544494278775467 MirTarget -0.357201953290914 2.86989439004612e-07 NA NA NA hsa-miR-106b-5p MAP3K12 -0.297128724729339 0.869294443540749 0.289698497751255 0.544494278775467 MirTarget -0.645780350121969 3.9616346543422e-17 NA NA NA hsa-miR-130b-3p MAP3K12 -0.221667315324818 0.824660172394714 0.289698497751255 0.544494278775467 MirTarget;miRNATAP -0.61222470875993 2.44770259194662e-19 NA NA NA hsa-miR-140-5p MAP3K12 -0.229213026275906 0.847330111738616 0.289698497751255 0.544494278775467 miRanda -0.279212037404924 0.00792997644571655 NA NA NA hsa-miR-17-5p MAP3K12 -0.175448849583061 0.934544015912731 0.289698497751255 0.544494278775467 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.429291832772957 6.49360168780865e-13 NA NA NA hsa-miR-186-5p MAP3K12 -0.318786974828757 0.85412722938961 0.289698497751255 0.544494278775467 MirTarget -0.655846637483638 1.02391989081146e-11 NA NA NA hsa-miR-191-5p MAP3K12 -0.482483793839469 0.815353309051705 0.289698497751255 0.544494278775467 MirTarget -0.585931883685019 5.74794247566322e-16 NA NA NA hsa-miR-19a-3p MAP3K12 -0.206793507801887 0.844637784802316 0.289698497751255 0.544494278775467 MirTarget -0.373923494561765 7.00696065226494e-11 NA NA NA hsa-miR-19b-3p MAP3K12 -0.0268530183621474 0.986656783046572 0.289698497751255 0.544494278775467 MirTarget -0.461034387213608 1.54774521766692e-11 NA NA NA hsa-miR-20a-5p MAP3K12 -0.179153323927949 0.928118119139752 0.289698497751255 0.544494278775467 miRNAWalker2_validate;miRTarBase;MirTarget -0.364099184072821 1.12741139920141e-09 NA NA NA hsa-miR-26b-5p MAP3K12 -0.0245931278499594 0.990377966314923 0.289698497751255 0.544494278775467 miRNAWalker2_validate -0.690744947020001 2.45484871352663e-14 NA NA NA hsa-miR-27a-3p MAP3K12 -0.123902317731458 0.958804393510999 0.289698497751255 0.544494278775467 miRNATAP -0.473973049126621 2.96577040353294e-05 NA NA NA hsa-miR-301a-3p MAP3K12 -0.105312511901769 0.831686745977347 0.289698497751255 0.544494278775467 MirTarget;miRNATAP -0.291040239120184 2.03967081126128e-06 NA NA NA hsa-miR-30b-5p MAP3K12 -0.0121430518253582 0.994622896704513 0.289698497751255 0.544494278775467 MirTarget -0.416919809300173 9.2710744612001e-10 NA NA NA hsa-miR-30c-5p MAP3K12 -0.298383882401475 0.865809030482001 0.289698497751255 0.544494278775467 MirTarget -0.490749080173236 7.31381249147566e-07 NA NA NA hsa-miR-30d-5p MAP3K12 -0.168211838771867 0.95173197030375 0.289698497751255 0.544494278775467 MirTarget -0.274035523412321 0.0025290908512742 NA NA NA hsa-miR-30e-5p MAP3K12 -0.0657075181381011 0.979684509181941 0.289698497751255 0.544494278775467 MirTarget -0.311326640957759 0.00531264898975557 NA NA NA hsa-miR-324-3p MAP3K12 -0.424387380347173 0.661528309116338 0.289698497751255 0.544494278775467 MirTarget -0.288256064454917 0.000941482185298697 NA NA NA hsa-miR-429 MAP3K12 -0.456485631615963 0.806240953400535 0.289698497751255 0.544494278775467 miRNATAP -0.469399062556866 2.72361083338031e-19 NA NA NA hsa-miR-454-3p MAP3K12 -0.101514866328011 0.843545158256191 0.289698497751255 0.544494278775467 MirTarget -0.470614535181294 1.64136017348383e-08 NA NA NA hsa-miR-577 MAP3K12 -1.06238199218774 0.326056761787754 0.289698497751255 0.544494278775467 PITA -0.259843128585862 2.07550978989512e-13 NA NA NA hsa-miR-590-3p MAP3K12 -0.279244755376859 0.59126669933662 0.289698497751255 0.544494278775467 miRanda -0.431427027850761 2.35079835175357e-14 NA NA NA hsa-miR-671-3p MAP3K12 -0.436798879412884 0.242347190629487 0.289698497751255 0.544494278775467 PITA -0.210084368902458 0.00507951365090569 NA NA NA hsa-miR-93-5p MAP3K12 -0.611073677204699 0.825297877093193 0.289698497751255 0.544494278775467 MirTarget -0.468020560226715 4.65168419057657e-10 NA NA NA hsa-miR-125b-5p MAP3K13 0.042694645848468 0.980586836124662 -0.242299225902198 0.602856683060646 miRNATAP -0.112192432729334 0.00303039836480913 NA NA NA hsa-miR-22-5p MAP3K13 -0.0785922550675187 0.93169760098231 -0.242299225902198 0.602856683060646 mirMAP -0.150726220957435 0.00102352581967663 NA NA NA hsa-miR-376c-3p MAP3K13 0.310149183310886 0.558689295035779 -0.242299225902198 0.602856683060646 mirMAP -0.134408131676853 0.0016799647602026 NA NA NA hsa-miR-708-5p MAP3K13 -0.0282907993048824 0.974929832201158 -0.242299225902198 0.602856683060646 MirTarget;miRNATAP -0.104403252883735 0.00633298555185279 NA NA NA hsa-let-7d-5p MAP3K2 -0.139747701175051 0.934164162708487 -0.0832110858772905 0.93593772699162 miRNATAP -0.199584037826553 0.000109528823395375 NA NA NA hsa-miR-106a-5p MAP3K2 -0.203919267842652 0.802213958426804 -0.0832110858772905 0.93593772699162 MirTarget;miRNATAP -0.108840922780389 0.000580877330183907 NA NA NA hsa-miR-106b-5p MAP3K2 -0.297128724729339 0.869294443540749 -0.0832110858772905 0.93593772699162 MirTarget;miRNATAP -0.146144526846842 6.11573016637231e-05 NA NA NA hsa-miR-126-5p MAP3K2 0.0815213541035824 0.956637332055185 -0.0832110858772905 0.93593772699162 MirTarget -0.149919103104664 0.000252142140212751 NA NA NA hsa-miR-130b-5p MAP3K2 -0.6472141103776 0.379096015222509 -0.0832110858772905 0.93593772699162 mirMAP;miRNATAP -0.101574782912382 0.00103006648829833 NA NA NA hsa-miR-22-5p MAP3K2 -0.0785922550675187 0.93169760098231 -0.0832110858772905 0.93593772699162 MirTarget -0.186112331894331 4.84042210545932e-10 NA NA NA hsa-miR-222-3p MAP3K2 -0.0265849318772702 0.984005474689108 -0.0832110858772905 0.93593772699162 MirTarget -0.111707697435185 0.0015479490184321 NA NA NA hsa-miR-26b-3p MAP3K2 -0.363222538866814 0.681115126930068 -0.0832110858772905 0.93593772699162 mirMAP -0.133196339312227 5.09980266278783e-05 NA NA NA hsa-miR-26b-5p MAP3K2 -0.0245931278499594 0.990377966314923 -0.0832110858772905 0.93593772699162 mirMAP;miRNATAP -0.143318478669729 0.000785329516429069 NA NA NA hsa-miR-27a-3p MAP3K2 -0.123902317731458 0.958804393510999 -0.0832110858772905 0.93593772699162 miRNATAP -0.154997131391658 0.00248067331446155 NA NA NA hsa-miR-28-5p MAP3K2 -0.106319459230459 0.940600125491369 -0.0832110858772905 0.93593772699162 miRanda -0.267467851621723 0.00175753183145156 NA NA NA hsa-miR-30b-5p MAP3K2 -0.0121430518253582 0.994622896704513 -0.0832110858772905 0.93593772699162 mirMAP;miRNATAP -0.148274860442095 1.66369956551914e-06 NA NA NA hsa-miR-30c-5p MAP3K2 -0.298383882401475 0.865809030482001 -0.0832110858772905 0.93593772699162 mirMAP;miRNATAP -0.134178949121473 0.00292592975464826 NA NA NA hsa-miR-323a-3p MAP3K2 0.279126405514894 0.478782330851768 -0.0832110858772905 0.93593772699162 MirTarget;miRNATAP -0.147106809784665 4.06037040964864e-08 NA NA NA hsa-miR-331-5p MAP3K2 -0.450673082073933 0.250361590873666 -0.0832110858772905 0.93593772699162 PITA;miRNATAP -0.104334072247469 0.00346522780422311 NA NA NA hsa-miR-369-3p MAP3K2 0.116576891957687 0.83230082995912 -0.0832110858772905 0.93593772699162 MirTarget -0.14708763116759 5.41858758631989e-06 NA NA NA hsa-miR-377-3p MAP3K2 -0.0435868040110954 0.893514136702459 -0.0832110858772905 0.93593772699162 mirMAP -0.128486889809661 4.01848615566206e-06 NA NA NA hsa-miR-409-5p MAP3K2 0.114137352474602 0.862758126973031 -0.0832110858772905 0.93593772699162 PITA -0.104034919692063 0.000138681143439131 NA NA NA hsa-miR-495-3p MAP3K2 0.00168200867117596 0.997533662527025 -0.0832110858772905 0.93593772699162 mirMAP -0.114164379142672 0.00472868540637396 NA NA NA hsa-miR-539-5p MAP3K2 0.124342970087029 0.801067485473643 -0.0832110858772905 0.93593772699162 mirMAP;miRNATAP -0.102475458837639 0.00356791147782067 NA NA NA hsa-miR-582-5p MAP3K2 -0.399450205475138 0.581227478860085 -0.0832110858772905 0.93593772699162 mirMAP -0.106286167818186 0.00215758085955909 NA NA NA hsa-miR-590-5p MAP3K2 -0.547819833829572 0.472735645776647 -0.0832110858772905 0.93593772699162 mirMAP -0.12322801553843 1.00938948356522e-05 NA NA NA hsa-miR-655-3p MAP3K2 0.225525683904601 0.432294495359122 -0.0832110858772905 0.93593772699162 MirTarget -0.128942143990971 8.56987719535546e-05 NA NA NA hsa-miR-92b-3p MAP3K2 -0.569866984318692 0.689321861489779 -0.0832110858772905 0.93593772699162 miRNAWalker2_validate -0.106032861858926 0.000536841949727367 NA NA NA hsa-let-7f-5p MAP3K3 0.048789917034723 0.987280455481631 0.00719296693481564 0.994535174295599 miRNATAP -0.234803867448236 0.000157342663712782 NA NA NA hsa-let-7g-5p MAP3K3 -0.200947212961157 0.922992045181955 0.00719296693481564 0.994535174295599 miRNATAP -0.365732143886311 2.95169885393123e-09 NA NA NA hsa-miR-106a-5p MAP3K3 -0.203919267842652 0.802213958426804 0.00719296693481564 0.994535174295599 MirTarget;miRNATAP -0.210777985214776 7.41024222203875e-08 NA NA NA hsa-miR-106b-5p MAP3K3 -0.297128724729339 0.869294443540749 0.00719296693481564 0.994535174295599 MirTarget;miRNATAP -0.35394396438828 4.33080936003141e-16 NA NA NA hsa-miR-107 MAP3K3 -0.0365118169251648 0.988364120226869 0.00719296693481564 0.994535174295599 PITA;miRanda;miRNATAP -0.24010990564516 0.000396702075346686 NA NA NA hsa-miR-1254 MAP3K3 -0.488929355953681 0.19551794273322 0.00719296693481564 0.994535174295599 miRNATAP -0.124748395351578 9.06402771326375e-05 NA NA NA hsa-miR-141-3p MAP3K3 -0.31994058840327 0.87774106909065 0.00719296693481564 0.994535174295599 miRNATAP -0.276695830823303 3.77624263633928e-18 NA NA NA hsa-miR-15a-5p MAP3K3 -0.0674049094129128 0.964835434214123 0.00719296693481564 0.994535174295599 MirTarget;miRNATAP -0.281554368724087 2.50850763247214e-09 NA NA NA hsa-miR-15b-5p MAP3K3 -0.272614787130877 0.87096541832188 0.00719296693481564 0.994535174295599 MirTarget;miRNATAP -0.248362547899876 2.49618038287154e-08 NA NA NA hsa-miR-16-5p MAP3K3 0.0135949734723564 0.994476223855607 0.00719296693481564 0.994535174295599 MirTarget;miRNATAP -0.280344227776875 1.79860080350815e-10 NA NA NA hsa-miR-17-5p MAP3K3 -0.175448849583061 0.934544015912731 0.00719296693481564 0.994535174295599 MirTarget;TargetScan;miRNATAP -0.270526966445891 3.38100803233246e-16 NA NA NA hsa-miR-182-5p MAP3K3 -0.104238497940557 0.973380614062243 0.00719296693481564 0.994535174295599 miRNATAP -0.231967469414805 1.10280496612913e-11 NA NA NA hsa-miR-188-5p MAP3K3 -0.568517670542551 0.324820848307954 0.00719296693481564 0.994535174295599 MirTarget;PITA;miRNATAP -0.154679551456121 1.20068908273243e-07 NA NA NA hsa-miR-193a-3p MAP3K3 -0.247265785363732 0.654363581941634 0.00719296693481564 0.994535174295599 PITA;miRNATAP -0.100809396623498 0.0079882144743576 NA NA NA hsa-miR-194-5p MAP3K3 -0.159001168846464 0.959682382557336 0.00719296693481564 0.994535174295599 miRNATAP -0.27801675911008 1.47730339663396e-15 NA NA NA hsa-miR-200a-3p MAP3K3 -0.367034437440907 0.851059894150266 0.00719296693481564 0.994535174295599 miRNATAP -0.238913791385558 4.40344751268768e-14 NA NA NA hsa-miR-20a-5p MAP3K3 -0.179153323927949 0.928118119139752 0.00719296693481564 0.994535174295599 MirTarget;miRNATAP -0.241760145542867 3.02229479833361e-13 NA NA NA hsa-miR-2110 MAP3K3 -0.317803483266315 0.250981343062022 0.00719296693481564 0.994535174295599 MirTarget -0.103662435827667 0.00826285398080673 NA NA NA hsa-miR-221-5p MAP3K3 0.0797468413208215 0.897597103192104 0.00719296693481564 0.994535174295599 mirMAP -0.164911085964555 1.533600073325e-08 NA NA NA hsa-miR-30c-1-3p MAP3K3 -0.202466672579761 0.511485842123022 0.00719296693481564 0.994535174295599 MirTarget -0.131131374360253 0.000145828898583146 NA NA NA hsa-miR-331-3p MAP3K3 -0.40204226129616 0.670588911553669 0.00719296693481564 0.994535174295599 mirMAP -0.169029080809871 8.87748918945755e-05 NA NA NA hsa-miR-33a-5p MAP3K3 -0.205788753603336 0.853314500865147 0.00719296693481564 0.994535174295599 miRNATAP -0.120017501932498 1.69474125443085e-08 NA NA NA hsa-miR-33b-5p MAP3K3 -0.161971614375297 0.737436207821109 0.00719296693481564 0.994535174295599 miRNATAP -0.113553518351657 1.87131154392913e-06 NA NA NA hsa-miR-429 MAP3K3 -0.456485631615963 0.806240953400535 0.00719296693481564 0.994535174295599 miRNATAP -0.260256462824034 1.51328160396147e-18 NA NA NA hsa-miR-484 MAP3K3 -0.179977202691249 0.886333755572375 0.00719296693481564 0.994535174295599 miRNATAP -0.264698047827014 8.36934110829555e-08 NA NA NA hsa-miR-505-3p MAP3K3 -0.469094267152605 0.690382680489578 0.00719296693481564 0.994535174295599 miRNATAP -0.214180858809002 8.18120271431963e-06 NA NA NA hsa-miR-625-5p MAP3K3 -0.690759472145277 0.210306534567564 0.00719296693481564 0.994535174295599 mirMAP -0.14175541959429 1.17063821809118e-06 NA NA NA hsa-miR-7-1-3p MAP3K3 -0.462485777435991 0.665899751398166 0.00719296693481564 0.994535174295599 mirMAP -0.232236917722207 1.31889864160996e-09 NA NA NA hsa-miR-93-5p MAP3K3 -0.611073677204699 0.825297877093193 0.00719296693481564 0.994535174295599 MirTarget;miRNATAP -0.271123057424731 1.44636656632434e-10 NA NA NA hsa-miR-96-5p MAP3K3 0.0854810872029343 0.923087820185031 0.00719296693481564 0.994535174295599 MirTarget;TargetScan;miRNATAP -0.268046688784247 1.38118735587335e-16 NA NA NA hsa-miR-106a-5p MAP3K5 -0.203919267842652 0.802213958426804 -0.419394110673393 0.721534433049761 miRNATAP -0.118850725670263 0.00809027838535234 NA NA NA hsa-miR-17-5p MAP3K5 -0.175448849583061 0.934544015912731 -0.419394110673393 0.721534433049761 TargetScan;miRNATAP -0.109132551341836 0.00581694716721536 NA NA NA hsa-miR-362-5p MAP3K6 -0.26647467080141 0.752024885130738 -0.306069252397644 0.760572288201979 miRNATAP -0.273079409131463 7.57066107031888e-07 NA NA NA hsa-miR-592 MAP3K6 -0.177670083168544 0.856226890424691 -0.306069252397644 0.760572288201979 miRNATAP -0.216464560470935 9.02828737573784e-14 NA NA NA hsa-miR-92a-3p MAP3K6 0.0278830870766349 0.993247426671713 -0.306069252397644 0.760572288201979 miRNAWalker2_validate -0.452430802084405 3.93150409960804e-10 NA NA NA hsa-miR-375 MAP3K8 -0.690952835064582 0.831716365337668 0.268285446253635 0.728241683643723 miRNAWalker2_validate -0.110781797331163 0.000752120657759743 NA NA NA hsa-miR-429 MAP3K8 -0.456485631615963 0.806240953400535 0.268285446253635 0.728241683643723 PITA;miRanda -0.129654183414795 0.00158652622088582 NA NA NA hsa-miR-1275 MAP4K1 -0.831342050607648 0.0803795852164229 -0.687211210090958 0.211861105154066 MirTarget -0.201324729828088 0.00772430248218323 NA NA NA hsa-miR-30c-1-3p MAP4K1 -0.202466672579761 0.511485842123022 -0.687211210090958 0.211861105154066 MirTarget -0.290938097946269 0.00477559556502614 NA NA NA hsa-let-7e-5p MAP4K3 0.211156073215582 0.922335699862928 0.0255676352000576 0.982998916175326 MirTarget;miRNATAP -0.151753935792841 0.000909949893037608 NA NA NA hsa-miR-142-3p MAP4K3 -0.154235241441331 0.946098054588918 0.0255676352000576 0.982998916175326 miRanda;miRNATAP -0.140123346612853 8.05671666599021e-09 NA NA NA hsa-miR-155-5p MAP4K3 -0.407235807706004 0.828669616718496 0.0255676352000576 0.982998916175326 MirTarget -0.110998908119207 0.000209317836543566 NA NA NA hsa-miR-22-5p MAP4K3 -0.0785922550675187 0.93169760098231 0.0255676352000576 0.982998916175326 MirTarget -0.103033767164476 0.000456327840571553 NA NA NA hsa-let-7d-5p MAP4K4 -0.139747701175051 0.934164162708487 0.00910589323361766 0.995244844042534 MirTarget -0.158690362737871 0.00882919512420919 NA NA NA hsa-let-7g-5p MAP4K4 -0.200947212961157 0.922992045181955 0.00910589323361766 0.995244844042534 MirTarget -0.232031694265596 6.43996535689936e-05 NA NA NA hsa-miR-141-3p MAP4K4 -0.31994058840327 0.87774106909065 0.00910589323361766 0.995244844042534 TargetScan -0.146986074625983 2.36593712384876e-06 24013097 To understand how miR-141 mediates the phenotype of pancreatic cancer cells a bioinformatics tool was used to identify MAP4K4 as a potential target of miR-141; The Dual-Luciferase reporter gene assay showed that miR-141 binds directly to the 3'-untranslated region 3'UTR of MAP4K4 to inhibit MAP4K4 expression; Western blot and quantitative real-time PCR qRT-PCR analyses revealed that MAP4K4 expression was inversely correlated with miR-141 expression both in pancreatic cancer samples and cell lines; In a nude mouse xenograft model both overexpression of miR-141 and knockdown of MAP4K4 significantly repressed pancreatic cancer cell growth; Therefore we conclude that miR-141 targets MAP4K4 acts as a tumor suppressor in pancreatic cancer cells and may serve as a novel therapeutic agent for miRNA-based pancreatic cancer therapy pancreatic cancer hsa-miR-148a-5p MAP4K4 -0.448099743845604 0.748419139652266 0.00910589323361766 0.995244844042534 MirTarget;miRNATAP -0.162795835544136 8.06977711754813e-06 NA NA NA hsa-miR-148b-5p MAP4K4 -0.236618793990305 0.43925706879726 0.00910589323361766 0.995244844042534 MirTarget -0.120238361297635 0.000391971564023715 NA NA NA hsa-miR-200b-3p MAP4K4 -0.426401948379212 0.863957108574195 0.00910589323361766 0.995244844042534 TargetScan -0.178486660178417 5.74482313445122e-07 NA NA NA hsa-miR-20a-3p MAP4K4 0.456808229166028 0.57674056136504 0.00910589323361766 0.995244844042534 MirTarget -0.101331034681915 8.679343371957e-05 NA NA NA hsa-miR-29a-3p MAP4K4 0.01127474410284 0.996977020481272 0.00910589323361766 0.995244844042534 miRNATAP -0.188116936888476 0.000108435957243284 NA NA NA hsa-miR-29b-3p MAP4K4 -0.104016192263954 0.958988036765397 0.00910589323361766 0.995244844042534 miRNATAP -0.134399615450771 0.000267637081889835 NA NA NA hsa-miR-429 MAP4K4 -0.456485631615963 0.806240953400535 0.00910589323361766 0.995244844042534 PITA;miRanda;miRNATAP -0.138795448418218 1.68071320280428e-06 NA NA NA hsa-miR-576-5p MAP4K4 -0.506413219377403 0.417187951364173 0.00910589323361766 0.995244844042534 PITA -0.117538497554497 0.0016123880170775 NA NA NA hsa-miR-590-3p MAP4K4 -0.279244755376859 0.59126669933662 0.00910589323361766 0.995244844042534 miRanda -0.159676737103777 1.56220654053889e-07 NA NA NA hsa-miR-7-1-3p MAP4K4 -0.462485777435991 0.665899751398166 0.00910589323361766 0.995244844042534 mirMAP -0.115409970642552 0.00151265761203292 NA NA NA hsa-miR-130b-3p MAPK10 -0.221667315324818 0.824660172394714 0.277853609916948 0.499757905156418 miRNATAP -0.832310234327384 2.2381048276646e-17 NA NA NA hsa-miR-193a-3p MAPK10 -0.247265785363732 0.654363581941634 0.277853609916948 0.499757905156418 miRanda;miRNATAP -0.252213365553003 0.00870398994376484 NA NA NA hsa-miR-19a-3p MAPK10 -0.206793507801887 0.844637784802316 0.277853609916948 0.499757905156418 miRNATAP -0.684018875973696 4.827389622141e-18 NA NA NA hsa-miR-19b-3p MAPK10 -0.0268530183621474 0.986656783046572 0.277853609916948 0.499757905156418 miRNATAP -0.696419816886425 6.76561876995665e-13 NA NA NA hsa-miR-221-3p MAPK10 0.0906940388127513 0.959121118272534 0.277853609916948 0.499757905156418 miRNATAP -0.85742573028989 1.01791917727309e-12 NA NA NA hsa-miR-222-3p MAPK10 -0.0265849318772702 0.984005474689108 0.277853609916948 0.499757905156418 miRNATAP -0.880593901403205 6.71481319542536e-17 NA NA NA hsa-miR-29a-3p MAPK10 0.01127474410284 0.996977020481272 0.277853609916948 0.499757905156418 miRNATAP -0.691098479445333 1.45128452412974e-07 NA NA NA hsa-miR-29b-3p MAPK10 -0.104016192263954 0.958988036765397 0.277853609916948 0.499757905156418 miRNATAP -0.761303371269869 1.76988052622429e-15 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-301a-3p MAPK10 -0.105312511901769 0.831686745977347 0.277853609916948 0.499757905156418 miRNATAP -0.612353493044439 4.61795457460633e-13 NA NA NA hsa-miR-30d-3p MAPK10 -0.123474741320298 0.814905367625791 0.277853609916948 0.499757905156418 mirMAP -0.796380211200875 1.85348051868985e-13 NA NA NA hsa-miR-30e-3p MAPK10 -0.220498559176349 0.938660731870214 0.277853609916948 0.499757905156418 mirMAP -0.516722605634317 0.00602241545561428 NA NA NA hsa-miR-330-3p MAPK10 0.00298687748748416 0.994504006750491 0.277853609916948 0.499757905156418 PITA;miRNATAP -0.375477945370297 0.000760398661857965 NA NA NA hsa-miR-429 MAPK10 -0.456485631615963 0.806240953400535 0.277853609916948 0.499757905156418 miRNATAP -0.63546405917023 3.52018243839143e-17 NA NA NA hsa-miR-450b-5p MAPK10 -0.0136687538973108 0.983149761399849 0.277853609916948 0.499757905156418 mirMAP -0.334790980428701 0.00164827821846065 NA NA NA hsa-miR-454-3p MAPK10 -0.101514866328011 0.843545158256191 0.277853609916948 0.499757905156418 miRNATAP -0.717456429396768 1.33940482149645e-09 NA NA NA hsa-miR-455-5p MAPK10 -0.139599153671262 0.865744220236311 0.277853609916948 0.499757905156418 miRanda -0.270878318986493 0.00909782838990037 NA NA NA hsa-miR-548o-3p MAPK10 -0.191447572716994 0.517725546183501 0.277853609916948 0.499757905156418 mirMAP -0.462430047984935 4.46197714322552e-07 NA NA NA hsa-miR-582-5p MAPK10 -0.399450205475138 0.581227478860085 0.277853609916948 0.499757905156418 PITA -0.605577911431605 1.99297551024098e-08 NA NA NA hsa-miR-590-3p MAPK10 -0.279244755376859 0.59126669933662 0.277853609916948 0.499757905156418 miRanda;mirMAP -0.669311815061267 4.2846409042703e-17 NA NA NA hsa-miR-590-5p MAPK10 -0.547819833829572 0.472735645776647 0.277853609916948 0.499757905156418 PITA;miRanda;miRNATAP -0.775102686172998 6.76449100692106e-21 NA NA NA hsa-miR-935 MAPK10 0.0536667023984385 0.939418255464024 0.277853609916948 0.499757905156418 miRNATAP -0.225220660326491 1.42825991928949e-07 NA NA NA hsa-miR-940 MAPK10 -0.225788347550697 0.680055767105815 0.277853609916948 0.499757905156418 PITA;miRNATAP -0.415226368453551 5.09031496952449e-09 NA NA NA hsa-miR-34c-5p MAPK13 -0.018707656771723 0.952788306178575 0.0881380051257299 0.956377720524338 miRanda;miRNATAP -0.117194532291702 0.00380186492377672 NA NA NA hsa-miR-125a-3p MAPK14 0.14689780893708 0.724764670752407 0.126862806226981 0.93082539746715 miRanda -0.101644260192556 1.57953133764737e-06 NA NA NA hsa-miR-125a-5p MAPK14 -0.00183986061615382 0.999158100170883 0.126862806226981 0.93082539746715 PITA;miRanda;miRNATAP -0.126033093834707 0.000340167481930466 NA NA NA hsa-miR-142-5p MAPK14 -0.118920788314118 0.929665277963083 0.126862806226981 0.93082539746715 PITA -0.128580807732311 6.92215500769448e-08 NA NA NA hsa-miR-145-3p MAPK14 0.134827892912136 0.913156302847575 0.126862806226981 0.93082539746715 MirTarget;miRNATAP -0.10151436648997 0.0017733764283353 NA NA NA hsa-miR-22-3p MAPK14 0.0592693913158495 0.986564295498741 0.126862806226981 0.93082539746715 MirTarget;miRNATAP -0.165307345766113 0.000418487995641222 NA NA NA hsa-miR-27a-3p MAPK14 -0.123902317731458 0.958804393510999 0.126862806226981 0.93082539746715 MirTarget;miRNATAP -0.117533872886964 0.0068147080833257 NA NA NA hsa-miR-27b-3p MAPK14 -0.14277121795778 0.951937409841932 0.126862806226981 0.93082539746715 MirTarget;miRNATAP -0.137206910023868 0.00597097955207623 NA NA NA hsa-miR-320b MAPK14 -0.23561798088153 0.859222532827992 0.126862806226981 0.93082539746715 PITA;miRanda -0.108587989585344 0.000163703855719314 NA NA NA hsa-miR-342-3p MAPK14 -0.371626144515113 0.77313668985267 0.126862806226981 0.93082539746715 miRanda -0.139323146663097 2.17704241405813e-07 NA NA NA hsa-miR-130a-3p MAPK8 0.0910074087716906 0.929098200371948 -0.319170851710442 0.713899940923572 mirMAP -0.147493968259864 1.00993606990742e-06 NA NA NA hsa-miR-193b-3p MAPK8 0.0672068426635715 0.951480422273678 -0.319170851710442 0.713899940923572 miRNAWalker2_validate -0.106177901094541 0.00010813031062645 NA NA NA hsa-miR-214-3p MAPK8 0.198015895663265 0.797041683257943 -0.319170851710442 0.713899940923572 miRNAWalker2_validate -0.106280310352835 1.00012795110538e-06 19859982 HeLa cells that stably overexpress miR-214 downregulate the expression of MEK3 and JNK1 at both mRNA and protein levels; Further investigation revealed that miR-214 regulates the expression of MEK3 and JNK1 by targeting the 3'UTRs of these genes; Collectively these results suggest that miR-214 negatively regulates HeLa cell proliferation by targeting the noncoding regions of MEK3 and JNK1 mRNAs cervical and endocervical cancer hsa-miR-22-5p MAPK8 -0.0785922550675187 0.93169760098231 -0.319170851710442 0.713899940923572 mirMAP -0.129099178124462 4.99897569863785e-06 NA NA NA hsa-miR-30b-5p MAPK8 -0.0121430518253582 0.994622896704513 -0.319170851710442 0.713899940923572 mirMAP -0.118491315163398 4.11391777534363e-05 NA NA NA hsa-miR-30c-5p MAPK8 -0.298383882401475 0.865809030482001 -0.319170851710442 0.713899940923572 mirMAP -0.136394758639834 0.00107809048076701 NA NA NA hsa-miR-376a-5p MAPK8 0.0978680856849549 0.773217338913054 -0.319170851710442 0.713899940923572 mirMAP -0.102493277664627 6.72583489111155e-05 NA NA NA hsa-miR-495-3p MAPK8 0.00168200867117596 0.997533662527025 -0.319170851710442 0.713899940923572 mirMAP -0.146650526517664 7.87292470161155e-05 NA NA NA hsa-miR-191-3p MAPK8IP1 -0.747855046248289 0.138513215824587 0.763910231265826 0.234204704544982 miRNAWalker2_validate -0.162743984427053 0.00824796900188301 NA NA NA hsa-miR-221-5p MAPK8IP1 0.0797468413208215 0.897597103192104 0.763910231265826 0.234204704544982 MirTarget -0.251960006103229 5.95630970404252e-05 NA NA NA hsa-let-7a-5p MAPK8IP2 -0.0620211756550422 0.985006886285188 0.139557400476581 0.795705318180654 mirMAP -0.731751620607465 0.00260815534037709 NA NA NA hsa-let-7i-5p MAPK9 -0.200792135853451 0.922018647874073 -0.0687722126219112 0.958326759664496 miRNATAP -0.139568596213236 0.00470113649742568 NA NA NA hsa-miR-199a-3p MAPK9 0.0782166873040424 0.973766909565326 -0.0687722126219112 0.958326759664496 miRNAWalker2_validate -0.100016761572209 0.00211211499601589 NA NA NA hsa-miR-10a-5p MAPT 0.0740585720685925 0.983770933356406 0.905865656165284 0.0672676439392023 mirMAP -0.528398526604644 2.02468404671292e-05 NA NA NA hsa-miR-1254 MAPT -0.488929355953681 0.19551794273322 0.905865656165284 0.0672676439392023 MirTarget -0.473041374870102 3.8834734365763e-06 NA NA NA hsa-miR-1275 MAPT -0.831342050607648 0.0803795852164229 0.905865656165284 0.0672676439392023 MirTarget -0.337832821862335 3.44977119978374e-05 NA NA NA hsa-miR-148b-5p MAPT -0.236618793990305 0.43925706879726 0.905865656165284 0.0672676439392023 mirMAP -0.593168520956949 4.27021848551531e-07 NA NA NA hsa-miR-17-3p MAPT 0.100221625453134 0.960113387014848 0.905865656165284 0.0672676439392023 mirMAP -0.795098900745626 7.45765838338469e-10 NA NA NA hsa-miR-18a-3p MAPT -0.270443061178857 0.535291623032886 0.905865656165284 0.0672676439392023 MirTarget;miRNATAP -0.465510686837274 6.16042763535688e-07 NA NA NA hsa-miR-24-3p MAPT -0.0484778924256624 0.985274054814493 0.905865656165284 0.0672676439392023 mirMAP -1.03683780362241 7.15484903412099e-05 NA NA NA hsa-miR-27a-3p MAPT -0.123902317731458 0.958804393510999 0.905865656165284 0.0672676439392023 miRNATAP -0.95928970205815 3.33666494786622e-06 NA NA NA hsa-miR-27b-5p MAPT -0.331337007788532 0.686623472774964 0.905865656165284 0.0672676439392023 mirMAP -0.613144098642693 0.0011059125193602 NA NA NA hsa-miR-29a-5p MAPT -0.31835175571979 0.600442757817281 0.905865656165284 0.0672676439392023 MirTarget;miRNATAP -0.575059309762356 9.61925648059146e-07 NA NA NA hsa-miR-30e-3p MAPT -0.220498559176349 0.938660731870214 0.905865656165284 0.0672676439392023 mirMAP -0.927350620926242 0.000102215593288651 NA NA NA hsa-miR-335-5p MAPT -0.0284895175847679 0.973380867832231 0.905865656165284 0.0672676439392023 mirMAP -0.444513525172099 0.000189467437177314 NA NA NA hsa-miR-34a-5p MAPT -0.50188164870224 0.742034237185732 0.905865656165284 0.0672676439392023 MirTarget;miRNATAP -0.462093396788471 0.000922823665887179 NA NA NA hsa-miR-361-5p MAPT -0.138735309928775 0.941495130308343 0.905865656165284 0.0672676439392023 miRanda -0.750048862932744 0.000683374567920443 NA NA NA hsa-miR-362-3p MAPT -0.721040238345347 0.0345881362485733 0.905865656165284 0.0672676439392023 MirTarget -0.454607868568439 1.54602352399018e-05 NA NA NA hsa-miR-421 MAPT -0.182032017078616 0.734704500318599 0.905865656165284 0.0672676439392023 mirMAP -0.520676493111321 2.66666510760509e-05 NA NA NA hsa-miR-429 MAPT -0.456485631615963 0.806240953400535 0.905865656165284 0.0672676439392023 miRNATAP -0.676854420543065 8.43875690914749e-12 NA NA NA hsa-miR-450b-5p MAPT -0.0136687538973108 0.983149761399849 0.905865656165284 0.0672676439392023 mirMAP -0.589946510021668 1.18801973696705e-05 NA NA NA hsa-miR-484 MAPT -0.179977202691249 0.886333755572375 0.905865656165284 0.0672676439392023 mirMAP -0.925056165147652 5.87474186062177e-09 NA NA NA hsa-miR-505-5p MAPT -0.555858818875454 0.317679205488749 0.905865656165284 0.0672676439392023 MirTarget -0.39228219892112 0.00248454625981733 NA NA NA hsa-miR-548o-3p MAPT -0.191447572716994 0.517725546183501 0.905865656165284 0.0672676439392023 mirMAP -0.533777312031264 5.94558112837236e-06 NA NA NA hsa-miR-582-3p MAPT -0.2334649592375 0.897678119160318 0.905865656165284 0.0672676439392023 PITA;miRNATAP -0.703108648185854 1.53102317060513e-07 NA NA NA hsa-miR-589-3p MAPT -0.835836305204965 0.0112001563801511 0.905865656165284 0.0672676439392023 mirMAP -0.370647216461297 0.000246788612952276 NA NA NA hsa-miR-589-5p MAPT -0.448771545046784 0.722725226273464 0.905865656165284 0.0672676439392023 mirMAP -0.808550322445571 5.12723267814813e-06 NA NA NA hsa-miR-7-1-3p MAPT -0.462485777435991 0.665899751398166 0.905865656165284 0.0672676439392023 mirMAP -0.750348332335012 1.41248673714324e-09 NA NA NA hsa-miR-760 MAPT -0.669469782471462 0.0773517068284613 0.905865656165284 0.0672676439392023 MirTarget -0.355515740740704 6.66704933888325e-05 NA NA NA hsa-miR-93-3p MAPT -0.438355548962673 0.549902689385444 0.905865656165284 0.0672676439392023 mirMAP -0.680182130377396 3.75746665283081e-08 NA NA NA hsa-miR-940 MAPT -0.225788347550697 0.680055767105815 0.905865656165284 0.0672676439392023 mirMAP -0.40500278060591 1.18346145235059e-05 NA NA NA hsa-miR-96-5p MAPT 0.0854810872029343 0.923087820185031 0.905865656165284 0.0672676439392023 mirMAP -0.573733351255259 1.7394127145952e-07 NA NA NA hsa-miR-361-5p MAX -0.138735309928775 0.941495130308343 -0.160350600216592 0.907111098989172 miRanda -0.123088887475231 0.00946523729876536 NA NA NA hsa-let-7a-3p MEF2C -0.215598045625677 0.85543299203799 0.174491220363078 0.828081225511471 MirTarget;miRNATAP -0.444495121511938 2.38223100299587e-08 NA NA NA hsa-let-7f-1-3p MEF2C -0.31101436822914 0.693407210545374 0.174491220363078 0.828081225511471 MirTarget -0.561498499990838 2.80114634460128e-07 NA NA NA hsa-let-7f-2-3p MEF2C -0.0455032713433074 0.882115725419367 0.174491220363078 0.828081225511471 mirMAP -0.37070316872556 1.78789157128034e-09 NA NA NA hsa-let-7f-5p MEF2C 0.048789917034723 0.987280455481631 0.174491220363078 0.828081225511471 miRNATAP -0.312030476543443 0.00633140443627173 NA NA NA hsa-let-7g-5p MEF2C -0.200947212961157 0.922992045181955 0.174491220363078 0.828081225511471 miRNATAP -0.742346924371393 2.61503792433498e-11 NA NA NA hsa-miR-101-5p MEF2C -0.27876696778882 0.558836382493107 0.174491220363078 0.828081225511471 MirTarget -0.203500654189164 0.00107137993699155 NA NA NA hsa-miR-107 MEF2C -0.0365118169251648 0.988364120226869 0.174491220363078 0.828081225511471 miRanda -0.389348318824969 0.00170613207397284 NA NA NA hsa-miR-10a-3p MEF2C -0.0996469316906681 0.882902638592481 0.174491220363078 0.828081225511471 miRNATAP -0.39024243326487 4.82438166927102e-12 NA NA NA hsa-miR-1296-5p MEF2C -0.639266760267726 0.236989089559211 0.174491220363078 0.828081225511471 MirTarget -0.315343869967882 3.88589386497263e-06 NA NA NA hsa-miR-130b-5p MEF2C -0.6472141103776 0.379096015222509 0.174491220363078 0.828081225511471 MirTarget;miRNATAP -0.5418773614494 6.86302516545592e-16 NA NA NA hsa-miR-135b-5p MEF2C 0.631573976263484 0.610028066417462 0.174491220363078 0.828081225511471 MirTarget -0.282993400600362 6.49754731190669e-11 NA NA NA hsa-miR-182-5p MEF2C -0.104238497940557 0.973380614062243 0.174491220363078 0.828081225511471 MirTarget;miRNATAP -0.230690684521531 0.000364094321206521 NA NA NA hsa-miR-183-5p MEF2C -0.0549974865878067 0.984855271688809 0.174491220363078 0.828081225511471 MirTarget;miRNATAP -0.248333731197008 5.6509554882162e-05 NA NA NA hsa-miR-186-5p MEF2C -0.318786974828757 0.85412722938961 0.174491220363078 0.828081225511471 miRNATAP -0.636200294898073 1.95593558769568e-10 NA NA NA hsa-miR-188-5p MEF2C -0.568517670542551 0.324820848307954 0.174491220363078 0.828081225511471 MirTarget;PITA -0.330005785325477 3.72959003658671e-10 NA NA NA hsa-miR-18a-3p MEF2C -0.270443061178857 0.535291623032886 0.174491220363078 0.828081225511471 MirTarget;miRNATAP -0.318215926572953 8.80681689605948e-10 NA NA NA hsa-miR-18a-5p MEF2C -0.498318455303917 0.61264091975585 0.174491220363078 0.828081225511471 MirTarget -0.342973874390973 3.9315222865775e-11 NA NA NA hsa-miR-18b-5p MEF2C -0.0473300652227538 0.899981261531446 0.174491220363078 0.828081225511471 MirTarget -0.271577956621459 1.54238234197811e-07 NA NA NA hsa-miR-194-5p MEF2C -0.159001168846464 0.959682382557336 0.174491220363078 0.828081225511471 miRNATAP -0.392047315539522 2.26894832441875e-09 NA NA NA hsa-miR-19a-3p MEF2C -0.206793507801887 0.844637784802316 0.174491220363078 0.828081225511471 miRNATAP -0.4401359695367 3.66504971221813e-14 NA NA NA hsa-miR-19b-3p MEF2C -0.0268530183621474 0.986656783046572 0.174491220363078 0.828081225511471 miRNATAP -0.495230429842916 1.60132857613116e-12 NA NA NA hsa-miR-200c-5p MEF2C -1.06750203254758 0.417719716654428 0.174491220363078 0.828081225511471 MirTarget -0.303544114911781 1.8902356174154e-07 NA NA NA hsa-miR-203a-3p MEF2C -0.265248086637561 0.931593594361942 0.174491220363078 0.828081225511471 MirTarget -0.332862188320801 3.55287749687353e-10 NA NA NA hsa-miR-23a-3p MEF2C -0.122198715333656 0.962717452143511 0.174491220363078 0.828081225511471 MirTarget;miRNATAP -0.526842452941135 0.000105237832632557 NA NA NA hsa-miR-26a-1-3p MEF2C -0.429875601809349 0.182136384322617 0.174491220363078 0.828081225511471 mirMAP -0.353970090711107 8.99971688721458e-09 NA NA NA hsa-miR-26a-2-3p MEF2C -0.427772454814258 0.28776911697575 0.174491220363078 0.828081225511471 mirMAP -0.389493165030269 1.61973864504053e-09 NA NA NA hsa-miR-26b-5p MEF2C -0.0245931278499594 0.990377966314923 0.174491220363078 0.828081225511471 miRNAWalker2_validate;miRNATAP -0.60319149405561 2.3649084645808e-10 NA NA NA hsa-miR-27a-3p MEF2C -0.123902317731458 0.958804393510999 0.174491220363078 0.828081225511471 miRNATAP -0.645221572553186 2.07853628351466e-08 NA NA NA hsa-miR-30d-3p MEF2C -0.123474741320298 0.814905367625791 0.174491220363078 0.828081225511471 MirTarget;miRNATAP -0.450724382610563 1.81099468073302e-08 NA NA NA hsa-miR-32-3p MEF2C -0.568003960723004 0.13133163420273 0.174491220363078 0.828081225511471 mirMAP -0.411768403064603 1.67221814451664e-16 NA NA NA hsa-miR-320a MEF2C -0.416546433767628 0.840202138616422 0.174491220363078 0.828081225511471 miRanda -0.258515018933111 0.00327639883555523 NA NA NA hsa-miR-324-3p MEF2C -0.424387380347173 0.661528309116338 0.174491220363078 0.828081225511471 miRNATAP -0.387115224910606 1.35830332583893e-05 NA NA NA hsa-miR-331-5p MEF2C -0.450673082073933 0.250361590873666 0.174491220363078 0.828081225511471 PITA -0.454610041738596 1.36754361250824e-08 NA NA NA hsa-miR-335-3p MEF2C -0.244830745789445 0.88450019116631 0.174491220363078 0.828081225511471 MirTarget;mirMAP -0.343693129955971 1.83425196519898e-07 NA NA NA hsa-miR-338-3p MEF2C 0.49158501750012 0.788483749194189 0.174491220363078 0.828081225511471 miRNATAP -0.194864937868492 0.00035673411099563 NA NA NA hsa-miR-33a-3p MEF2C -0.794543849238581 0.0105203072007922 0.174491220363078 0.828081225511471 MirTarget;mirMAP;miRNATAP -0.33189306649111 5.27342119452395e-08 NA NA NA hsa-miR-33b-5p MEF2C -0.161971614375297 0.737436207821109 0.174491220363078 0.828081225511471 mirMAP -0.311343794804963 1.15105163015997e-13 NA NA NA hsa-miR-362-3p MEF2C -0.721040238345347 0.0345881362485733 0.174491220363078 0.828081225511471 MirTarget;miRNATAP -0.310200662766588 1.2679255290445e-07 NA NA NA hsa-miR-369-3p MEF2C 0.116576891957687 0.83230082995912 0.174491220363078 0.828081225511471 mirMAP -0.22842910103455 0.00248116712329113 NA NA NA hsa-miR-374a-5p MEF2C -0.343007247142618 0.766921280269271 0.174491220363078 0.828081225511471 mirMAP -0.294600217680024 0.00530098724406441 NA NA NA hsa-miR-421 MEF2C -0.182032017078616 0.734704500318599 0.174491220363078 0.828081225511471 PITA;miRanda;miRNATAP -0.261751447947228 0.000193065986587217 NA NA NA hsa-miR-425-5p MEF2C -0.354606074344121 0.845979106734409 0.174491220363078 0.828081225511471 MirTarget;miRNATAP -0.436462665567055 1.72670814809168e-11 NA NA NA hsa-miR-429 MEF2C -0.456485631615963 0.806240953400535 0.174491220363078 0.828081225511471 miRanda;miRNATAP -0.438534486235153 1.27386415990066e-15 NA NA NA hsa-miR-450b-5p MEF2C -0.0136687538973108 0.983149761399849 0.174491220363078 0.828081225511471 MirTarget;PITA;miRNATAP -0.226560518273251 0.00320917318290085 NA NA NA hsa-miR-452-5p MEF2C -0.0504626418153507 0.973874641360401 0.174491220363078 0.828081225511471 MirTarget;miRNATAP -0.199798393894807 0.00491780194454386 NA NA NA hsa-miR-491-3p MEF2C -0.513850326596847 0.137836285146052 0.174491220363078 0.828081225511471 MirTarget;PITA;mirMAP;miRNATAP -0.274705833277852 6.66772190806315e-06 NA NA NA hsa-miR-501-5p MEF2C -0.834032628506285 0.0582725160418523 0.174491220363078 0.828081225511471 MirTarget;PITA;miRNATAP -0.234433509779779 1.52324975937295e-05 NA NA NA hsa-miR-539-5p MEF2C 0.124342970087029 0.801067485473643 0.174491220363078 0.828081225511471 miRNATAP -0.251355656448932 0.00189504412574932 NA NA NA hsa-miR-548o-3p MEF2C -0.191447572716994 0.517725546183501 0.174491220363078 0.828081225511471 MirTarget -0.226108623846018 0.000762948199587924 NA NA NA hsa-miR-550a-3p MEF2C -0.6199901113685 0.0836206511566976 0.174491220363078 0.828081225511471 MirTarget -0.348154619470958 5.70403666325213e-09 NA NA NA hsa-miR-590-3p MEF2C -0.279244755376859 0.59126669933662 0.174491220363078 0.828081225511471 mirMAP -0.435690740100962 8.80004374039318e-14 NA NA NA hsa-miR-590-5p MEF2C -0.547819833829572 0.472735645776647 0.174491220363078 0.828081225511471 MirTarget;PITA;miRanda;miRNATAP -0.514046911036285 2.49379104370651e-17 NA NA NA hsa-miR-7-1-3p MEF2C -0.462485777435991 0.665899751398166 0.174491220363078 0.828081225511471 MirTarget;mirMAP -0.504234302102945 1.93213550557961e-13 NA NA NA hsa-miR-744-3p MEF2C -0.540090234027722 0.490553451682436 0.174491220363078 0.828081225511471 MirTarget;miRNATAP -0.344022196109793 1.40635502747337e-07 NA NA NA hsa-miR-760 MEF2C -0.669469782471462 0.0773517068284613 0.174491220363078 0.828081225511471 miRNATAP -0.170845570963984 0.000723196386433168 NA NA NA hsa-miR-92a-3p MEF2C 0.0278830870766349 0.993247426671713 0.174491220363078 0.828081225511471 miRNAWalker2_validate -0.481843937891458 4.08782470358919e-11 NA NA NA hsa-miR-940 MEF2C -0.225788347550697 0.680055767105815 0.174491220363078 0.828081225511471 PITA;miRNATAP -0.202100862262974 0.000114819545060967 NA NA NA hsa-miR-96-5p MEF2C 0.0854810872029343 0.923087820185031 0.174491220363078 0.828081225511471 miRNATAP -0.414964559877843 7.47164910679266e-12 NA NA NA hsa-let-7f-5p MRAS 0.048789917034723 0.987280455481631 0.228664941061626 0.758599416375864 mirMAP -0.492725449031154 0.000185736515304168 NA NA NA hsa-let-7g-5p MRAS -0.200947212961157 0.922992045181955 0.228664941061626 0.758599416375864 mirMAP -1.00901869929983 1.68799750465389e-15 NA NA NA hsa-miR-130b-5p MRAS -0.6472141103776 0.379096015222509 0.228664941061626 0.758599416375864 mirMAP -0.657771473971772 1.92628311736042e-17 NA NA NA hsa-miR-135b-5p MRAS 0.631573976263484 0.610028066417462 0.228664941061626 0.758599416375864 miRNATAP -0.272958164095573 9.4502791724407e-08 NA NA NA hsa-miR-15a-5p MRAS -0.0674049094129128 0.964835434214123 0.228664941061626 0.758599416375864 miRNATAP -0.695336092055382 1.78309058388596e-12 NA NA NA hsa-miR-15b-5p MRAS -0.272614787130877 0.87096541832188 0.228664941061626 0.758599416375864 miRNATAP -0.669060159174311 4.18318981262801e-13 NA NA NA hsa-miR-16-5p MRAS 0.0135949734723564 0.994476223855607 0.228664941061626 0.758599416375864 miRNATAP -0.76917023869934 1.25617299958198e-17 NA NA NA hsa-miR-182-5p MRAS -0.104238497940557 0.973380614062243 0.228664941061626 0.758599416375864 miRNATAP -0.393514718321017 1.00181944972084e-07 NA NA NA hsa-miR-26a-1-3p MRAS -0.429875601809349 0.182136384322617 0.228664941061626 0.758599416375864 mirMAP -0.456606496977123 1.17937035699299e-10 NA NA NA hsa-miR-26a-2-3p MRAS -0.427772454814258 0.28776911697575 0.228664941061626 0.758599416375864 mirMAP -0.51846504538519 2.41592479332938e-12 NA NA NA hsa-miR-26b-5p MRAS -0.0245931278499594 0.990377966314923 0.228664941061626 0.758599416375864 miRNATAP -0.806242472983582 1.29060227796861e-13 NA NA NA hsa-miR-29a-3p MRAS 0.01127474410284 0.996977020481272 0.228664941061626 0.758599416375864 mirMAP -0.822593569660772 1.04123018863404e-14 NA NA NA hsa-miR-29a-5p MRAS -0.31835175571979 0.600442757817281 0.228664941061626 0.758599416375864 mirMAP -0.583345753296851 2.48014072431766e-15 NA NA NA hsa-miR-29b-3p MRAS -0.104016192263954 0.958988036765397 0.228664941061626 0.758599416375864 mirMAP -0.669885699152389 3.86125960530788e-17 NA NA NA hsa-miR-30d-3p MRAS -0.123474741320298 0.814905367625791 0.228664941061626 0.758599416375864 mirMAP -0.716400436311934 1.51229106504181e-15 NA NA NA hsa-miR-30e-3p MRAS -0.220498559176349 0.938660731870214 0.228664941061626 0.758599416375864 mirMAP -0.709623434600384 4.97027582039501e-06 NA NA NA hsa-miR-32-3p MRAS -0.568003960723004 0.13133163420273 0.228664941061626 0.758599416375864 mirMAP -0.536378179647598 3.15767201052886e-21 NA NA NA hsa-miR-324-5p MRAS -0.50063248413014 0.537416710557032 0.228664941061626 0.758599416375864 miRanda -0.467136609487543 1.25343979747189e-07 NA NA NA hsa-miR-335-3p MRAS -0.244830745789445 0.88450019116631 0.228664941061626 0.758599416375864 mirMAP -0.595478593731124 4.83540980464014e-16 NA NA NA hsa-miR-33a-3p MRAS -0.794543849238581 0.0105203072007922 0.228664941061626 0.758599416375864 mirMAP -0.447651098777327 1.58787763647451e-10 NA NA NA hsa-miR-362-3p MRAS -0.721040238345347 0.0345881362485733 0.228664941061626 0.758599416375864 miRanda -0.40183739471597 2.87317759911725e-09 NA NA NA hsa-miR-421 MRAS -0.182032017078616 0.734704500318599 0.228664941061626 0.758599416375864 miRanda -0.481606562058004 1.39703136004806e-09 NA NA NA hsa-miR-423-5p MRAS -0.140317642654 0.912448846587903 0.228664941061626 0.758599416375864 miRNATAP -0.448612361455293 1.19435673733541e-05 NA NA NA hsa-miR-424-5p MRAS 0.247080963500746 0.870154571783568 0.228664941061626 0.758599416375864 miRNATAP -0.242227723041348 0.000694464684015509 NA NA NA hsa-miR-429 MRAS -0.456485631615963 0.806240953400535 0.228664941061626 0.758599416375864 miRanda;miRNATAP -0.587690948034785 2.41633231763827e-21 NA NA NA hsa-miR-486-5p MRAS -0.547739229538641 0.696404149927963 0.228664941061626 0.758599416375864 miRanda -0.196533769584679 0.000620313969644355 NA NA NA hsa-miR-582-5p MRAS -0.399450205475138 0.581227478860085 0.228664941061626 0.758599416375864 mirMAP -0.346678237249235 0.000171801104590749 NA NA NA hsa-miR-652-3p MRAS -0.219946355190312 0.860742682824813 0.228664941061626 0.758599416375864 miRNAWalker2_validate -0.46080366073092 7.95303430348797e-07 NA NA NA hsa-miR-7-1-3p MRAS -0.462485777435991 0.665899751398166 0.228664941061626 0.758599416375864 mirMAP -0.6043905775395 2.56909253845426e-14 NA NA NA hsa-miR-96-5p MRAS 0.0854810872029343 0.923087820185031 0.228664941061626 0.758599416375864 TargetScan;miRNATAP -0.580063877289004 2.57556079702539e-17 NA NA NA hsa-miR-98-5p MRAS -0.168162186023221 0.898802461503524 0.228664941061626 0.758599416375864 mirMAP -0.513400316438533 7.69965616214843e-06 NA NA NA hsa-miR-320b MYC -0.23561798088153 0.859222532827992 -0.445372871610816 0.811492365164222 miRNAWalker2_validate -0.243607030835589 0.000321638494084035 26487644 miR 320b suppresses cell proliferation by targeting c Myc in human colorectal cancer cells; Overexpression of miR-320b in CRC cells was statistically correlated with a decrease of cell growth in vitro and in vivo while c-MYC was identified as a target gene of miR-320b in CRC; Furthermore it was found that up-regulation of c-Myc can attenuate the effects induced by miR-320b; Our identification of c-MYC as a target gene of miR-320b provides new insights into the pathophysiology of CRC proliferation and identifies miR-320b as a novel therapeutic target for the treatment of CRC colorectal cancer hsa-miR-146b-5p NF1 -0.402662509440887 0.837510937985091 0.077091149472758 0.958028470633233 miRanda -0.1325108207471 0.000152007685146501 NA NA NA hsa-miR-495-3p NF1 0.00168200867117596 0.997533662527025 0.077091149472758 0.958028470633233 mirMAP -0.12779647439882 0.00103090091212145 NA NA NA hsa-miR-130b-5p NFATC2 -0.6472141103776 0.379096015222509 0.20813885004158 0.707327065065389 MirTarget -0.371671936709306 0.000945478291859101 NA NA NA hsa-miR-16-2-3p NFATC2 -0.36717860153421 0.546850726070016 0.20813885004158 0.707327065065389 mirMAP -0.321323681153577 0.00260222712022902 NA NA NA hsa-miR-182-5p NFATC2 -0.104238497940557 0.973380614062243 0.20813885004158 0.707327065065389 mirMAP -0.265681273078806 0.00971009673872175 NA NA NA hsa-miR-200b-5p NFATC2 -0.502275384207405 0.722255155236927 0.20813885004158 0.707327065065389 mirMAP -0.305745975197229 0.00378458633137365 NA NA NA hsa-miR-26b-3p NFATC2 -0.363222538866814 0.681115126930068 0.20813885004158 0.707327065065389 MirTarget -0.317033936764729 0.00865242756037893 NA NA NA hsa-miR-31-3p NFATC2 0.199700996192121 0.762032341762692 0.20813885004158 0.707327065065389 MirTarget -0.235283031776912 5.29901232164249e-06 NA NA NA hsa-miR-340-5p NFATC2 -0.00276909425328853 0.99757361161055 0.20813885004158 0.707327065065389 miRNATAP -0.352511827102355 0.00983626337497569 NA NA NA hsa-miR-484 NFATC2 -0.179977202691249 0.886333755572375 0.20813885004158 0.707327065065389 MirTarget -0.415370166828549 0.00430698140074031 NA NA NA hsa-miR-590-3p NFATC2 -0.279244755376859 0.59126669933662 0.20813885004158 0.707327065065389 mirMAP -0.338313979685588 0.000466556910823497 NA NA NA hsa-miR-7-1-3p NFATC2 -0.462485777435991 0.665899751398166 0.20813885004158 0.707327065065389 mirMAP -0.334924596713898 0.00323544853973565 NA NA NA hsa-miR-7-5p NFATC2 0.209645143210379 0.773705612298441 0.20813885004158 0.707327065065389 MirTarget;miRNATAP -0.222229993016084 0.00222704126347517 NA NA NA hsa-miR-1254 NFATC4 -0.488929355953681 0.19551794273322 0.226055021146126 0.800900855175489 MirTarget -0.168494924567814 0.000786858710678943 NA NA NA hsa-miR-130b-5p NFATC4 -0.6472141103776 0.379096015222509 0.226055021146126 0.800900855175489 mirMAP -0.233289219374898 0.000130008396840311 NA NA NA hsa-miR-15b-3p NFATC4 -0.557749208157585 0.609181305423188 0.226055021146126 0.800900855175489 mirMAP -0.270368257837691 2.79109512958001e-05 NA NA NA hsa-miR-29a-3p NFATC4 0.01127474410284 0.996977020481272 0.226055021146126 0.800900855175489 miRNATAP -0.258362450735976 0.00188238181514646 NA NA NA hsa-miR-29b-3p NFATC4 -0.104016192263954 0.958988036765397 0.226055021146126 0.800900855175489 miRNATAP -0.225170145334363 0.000330589653812401 NA NA NA hsa-miR-320c NFATC4 -0.577462251570141 0.113597318870228 0.226055021146126 0.800900855175489 miRanda;mirMAP -0.136540488247642 0.00651845172795593 NA NA NA hsa-miR-361-3p NFATC4 -0.285313945920494 0.847726816983044 0.226055021146126 0.800900855175489 mirMAP -0.242143644855398 0.00961205807335463 NA NA NA hsa-miR-429 NFATC4 -0.456485631615963 0.806240953400535 0.226055021146126 0.800900855175489 miRNATAP -0.213342690177861 1.64741561365079e-05 NA NA NA hsa-miR-532-5p NFATC4 -0.349665553500088 0.878948352437467 0.226055021146126 0.800900855175489 mirMAP -0.261553245010297 2.98639232810069e-05 NA NA NA hsa-miR-625-5p NFATC4 -0.690759472145277 0.210306534567564 0.226055021146126 0.800900855175489 mirMAP -0.142491700464098 0.00216106794254422 NA NA NA hsa-miR-629-3p NFATC4 -0.495402745812008 0.333967382214384 0.226055021146126 0.800900855175489 mirMAP -0.197806130594455 8.82960626285602e-05 NA NA NA hsa-miR-98-5p NFKB2 -0.168162186023221 0.898802461503524 -0.197202958165541 0.881130324776153 miRNAWalker2_validate -0.176397153853226 0.00141956817464899 NA NA NA hsa-let-7b-5p NLK -0.228773940533783 0.938952933213741 0.214434715599375 0.830839712962495 miRNATAP -0.130424977621627 0.00311102435446934 NA NA NA hsa-let-7e-5p NLK 0.211156073215582 0.922335699862928 0.214434715599375 0.830839712962495 miRNATAP -0.143798339328613 0.00232162255220557 NA NA NA hsa-let-7i-5p NLK -0.200792135853451 0.922018647874073 0.214434715599375 0.830839712962495 miRNATAP -0.185812755181517 0.00112341117007832 NA NA NA hsa-miR-132-3p NLK -0.244143673573889 0.871752726220643 0.214434715599375 0.830839712962495 miRNATAP -0.198155050215153 3.50435694338891e-05 NA NA NA hsa-miR-146b-5p NLK -0.402662509440887 0.837510937985091 0.214434715599375 0.830839712962495 miRanda -0.19099789381006 4.66750054492802e-08 NA NA NA hsa-miR-330-5p NLK -0.283418953659271 0.815687101334695 0.214434715599375 0.830839712962495 MirTarget;PITA;miRanda;miRNATAP -0.119789137803744 0.00367235842016029 NA NA NA hsa-miR-342-3p NLK -0.371626144515113 0.77313668985267 0.214434715599375 0.830839712962495 miRanda -0.124795455162205 7.92183179587525e-05 NA NA NA hsa-miR-511-5p NLK -0.308591187445274 0.607200373476563 0.214434715599375 0.830839712962495 MirTarget -0.117056015401763 1.64388218292278e-05 NA NA NA hsa-miR-582-5p NLK -0.399450205475138 0.581227478860085 0.214434715599375 0.830839712962495 miRNATAP -0.110737279228243 0.00112944181508768 NA NA NA hsa-let-7e-5p NRAS 0.211156073215582 0.922335699862928 -0.124828619880436 0.932579310697412 MirTarget;miRNATAP -0.13435195257722 0.00396667581188335 NA NA NA hsa-miR-221-3p NTF3 0.0906940388127513 0.959121118272534 -0.257089163862745 0.636332266772515 miRNATAP -0.610109014654345 2.67344459535098e-07 NA NA NA hsa-miR-222-3p NTF3 -0.0265849318772702 0.984005474689108 -0.257089163862745 0.636332266772515 miRNATAP -0.52313575472335 8.7686929594132e-07 NA NA NA hsa-miR-335-5p NTF3 -0.0284895175847679 0.973380867832231 -0.257089163862745 0.636332266772515 miRNAWalker2_validate -0.254297552536586 0.00467425364710777 NA NA NA hsa-miR-590-3p NTF3 -0.279244755376859 0.59126669933662 -0.257089163862745 0.636332266772515 miRanda -0.238867138855125 0.00352466395294062 NA NA NA hsa-miR-590-5p NTF3 -0.547819833829572 0.472735645776647 -0.257089163862745 0.636332266772515 PITA;miRanda;miRNATAP -0.282294314485261 0.0010790491435192 NA NA NA hsa-miR-130b-3p NTRK2 -0.221667315324818 0.824660172394714 0.713957410525928 0.344227464503002 mirMAP -0.84860306305913 3.68116891250849e-06 NA NA NA hsa-miR-130b-5p NTRK2 -0.6472141103776 0.379096015222509 0.713957410525928 0.344227464503002 mirMAP -0.818046242261116 2.04435381224772e-06 NA NA NA hsa-miR-148a-5p NTRK2 -0.448099743845604 0.748419139652266 0.713957410525928 0.344227464503002 mirMAP -0.470909045599969 0.00866907323410485 NA NA NA hsa-miR-151a-5p NTRK2 -0.416333535986492 0.695673384848773 0.713957410525928 0.344227464503002 miRNATAP -0.798069900850692 3.15200099909301e-05 NA NA NA hsa-miR-15b-3p NTRK2 -0.557749208157585 0.609181305423188 0.713957410525928 0.344227464503002 mirMAP -1.03701612899491 9.73522451080546e-09 NA NA NA hsa-miR-17-3p NTRK2 0.100221625453134 0.960113387014848 0.713957410525928 0.344227464503002 miRNATAP -0.976533297109227 5.8165830360126e-08 NA NA NA hsa-miR-185-5p NTRK2 -0.294432218239008 0.820591478398594 0.713957410525928 0.344227464503002 mirMAP -0.779623016009143 0.0021334075140637 NA NA NA hsa-miR-186-5p NTRK2 -0.318786974828757 0.85412722938961 0.713957410525928 0.344227464503002 mirMAP -0.957383701195755 0.000144839968612385 NA NA NA hsa-miR-200c-3p NTRK2 -0.437282635857873 0.887118598436407 0.713957410525928 0.344227464503002 miRNAWalker2_validate;miRTarBase -0.6199899985899 0.000602799134319623 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-20a-3p NTRK2 0.456808229166028 0.57674056136504 0.713957410525928 0.344227464503002 mirMAP -0.60033772601526 1.28938210177587e-06 NA NA NA hsa-miR-301a-3p NTRK2 -0.105312511901769 0.831686745977347 0.713957410525928 0.344227464503002 mirMAP -0.59702518092561 0.00012887559022196 NA NA NA hsa-miR-30b-5p NTRK2 -0.0121430518253582 0.994622896704513 0.713957410525928 0.344227464503002 mirMAP -0.518136651655039 0.00350366761608414 NA NA NA hsa-miR-30d-3p NTRK2 -0.123474741320298 0.814905367625791 0.713957410525928 0.344227464503002 mirMAP -0.75947148446546 0.000144661247180184 NA NA NA hsa-miR-32-3p NTRK2 -0.568003960723004 0.13133163420273 0.713957410525928 0.344227464503002 mirMAP -0.393955653385373 0.00254657240224691 NA NA NA hsa-miR-32-5p NTRK2 -0.05993267619119 0.952975951594959 0.713957410525928 0.344227464503002 mirMAP -0.593687529017976 0.00074047888176755 NA NA NA hsa-miR-335-3p NTRK2 -0.244830745789445 0.88450019116631 0.713957410525928 0.344227464503002 mirMAP -0.586164490861426 0.000350559482261675 NA NA NA hsa-miR-33a-5p NTRK2 -0.205788753603336 0.853314500865147 0.713957410525928 0.344227464503002 mirMAP -0.440166951806151 4.80538013717642e-06 NA NA NA hsa-miR-33b-5p NTRK2 -0.161971614375297 0.737436207821109 0.713957410525928 0.344227464503002 mirMAP -0.346053614022834 0.00134849656880221 NA NA NA hsa-miR-369-3p NTRK2 0.116576891957687 0.83230082995912 0.713957410525928 0.344227464503002 mirMAP -0.51441210411069 0.00545821172882658 NA NA NA hsa-miR-374a-5p NTRK2 -0.343007247142618 0.766921280269271 0.713957410525928 0.344227464503002 mirMAP -0.792957457071796 0.00213131427236809 NA NA NA hsa-miR-377-3p NTRK2 -0.0435868040110954 0.893514136702459 0.713957410525928 0.344227464503002 mirMAP -0.469186765032496 0.00325676657980703 NA NA NA hsa-miR-421 NTRK2 -0.182032017078616 0.734704500318599 0.713957410525928 0.344227464503002 mirMAP -0.745837972793792 1.27502759209042e-05 NA NA NA hsa-miR-429 NTRK2 -0.456485631615963 0.806240953400535 0.713957410525928 0.344227464503002 PITA;miRanda;miRNATAP -0.607358789765713 1.69318009529954e-05 NA NA NA hsa-miR-452-3p NTRK2 -0.167134177977311 0.799008246175244 0.713957410525928 0.344227464503002 mirMAP -0.424826514888043 0.000882386795086219 NA NA NA hsa-miR-454-3p NTRK2 -0.101514866328011 0.843545158256191 0.713957410525928 0.344227464503002 mirMAP -1.03687565563906 1.01741231251894e-06 NA NA NA hsa-miR-455-3p NTRK2 -0.356341681711462 0.824635754440661 0.713957410525928 0.344227464503002 mirMAP -0.435834708344416 0.00407925932571666 NA NA NA hsa-miR-501-5p NTRK2 -0.834032628506285 0.0582725160418523 0.713957410525928 0.344227464503002 mirMAP -0.388955969272554 0.00376398178826822 NA NA NA hsa-miR-576-5p NTRK2 -0.506413219377403 0.417187951364173 0.713957410525928 0.344227464503002 PITA;mirMAP -0.620750548380737 0.000573279730246138 NA NA NA hsa-miR-577 NTRK2 -1.06238199218774 0.326056761787754 0.713957410525928 0.344227464503002 mirMAP -0.394769227040369 2.13251966281415e-05 NA NA NA hsa-miR-590-3p NTRK2 -0.279244755376859 0.59126669933662 0.713957410525928 0.344227464503002 PITA;miRanda;mirMAP -0.650284146592079 1.26751543217643e-05 NA NA NA hsa-miR-590-5p NTRK2 -0.547819833829572 0.472735645776647 0.713957410525928 0.344227464503002 miRanda;mirMAP -0.801561087461349 2.88717365367254e-07 NA NA NA hsa-miR-760 NTRK2 -0.669469782471462 0.0773517068284613 0.713957410525928 0.344227464503002 PITA;miRNATAP -0.320637386396562 0.00994890145462774 NA NA NA hsa-miR-940 NTRK2 -0.225788347550697 0.680055767105815 0.713957410525928 0.344227464503002 PITA -0.53900674685054 2.49123954783046e-05 NA NA NA hsa-miR-331-5p PDGFA -0.450673082073933 0.250361590873666 0.322821100258507 0.767865638706571 PITA;miRNATAP -0.263950239852047 0.000506838266187203 NA NA NA hsa-let-7d-5p PDGFB -0.139747701175051 0.934164162708487 0.313242927790498 0.743141773305227 miRNATAP -0.35910919131 0.000104487041240393 NA NA NA hsa-let-7f-5p PDGFB 0.048789917034723 0.987280455481631 0.313242927790498 0.743141773305227 miRNATAP -0.244280289349921 0.00604928509607363 NA NA NA hsa-let-7g-5p PDGFB -0.200947212961157 0.922992045181955 0.313242927790498 0.743141773305227 miRNATAP -0.480991322593709 4.82276901946855e-08 NA NA NA hsa-miR-17-5p PDGFB -0.175448849583061 0.934544015912731 0.313242927790498 0.743141773305227 TargetScan -0.259524570506942 1.31684333799908e-07 NA NA NA hsa-miR-18a-3p PDGFB -0.270443061178857 0.535291623032886 0.313242927790498 0.743141773305227 MirTarget -0.122279258136473 0.00341292486566504 NA NA NA hsa-miR-26b-5p PDGFB -0.0245931278499594 0.990377966314923 0.313242927790498 0.743141773305227 miRNAWalker2_validate -0.347387618826242 4.49913892640547e-06 NA NA NA hsa-miR-29a-3p PDGFB 0.01127474410284 0.996977020481272 0.313242927790498 0.743141773305227 MirTarget;miRNATAP -0.288293585647454 0.000119375011677654 NA NA NA hsa-miR-29b-3p PDGFB -0.104016192263954 0.958988036765397 0.313242927790498 0.743141773305227 MirTarget;miRNATAP -0.241085738055695 2.00161076900261e-05 NA NA NA hsa-miR-335-5p PDGFB -0.0284895175847679 0.973380867832231 0.313242927790498 0.743141773305227 mirMAP -0.290025221620047 1.51950551363649e-08 NA NA NA hsa-miR-362-3p PDGFB -0.721040238345347 0.0345881362485733 0.313242927790498 0.743141773305227 miRanda -0.15824200229485 0.000678732510299074 NA NA NA hsa-miR-590-3p PDGFB -0.279244755376859 0.59126669933662 0.313242927790498 0.743141773305227 PITA;miRanda;miRNATAP -0.253879073321591 5.92294321424903e-08 NA NA NA hsa-let-7a-3p PDGFRA -0.215598045625677 0.85543299203799 -0.145858107393819 0.902950557320272 mirMAP -0.46804730928802 1.13954952980613e-05 NA NA NA hsa-let-7f-1-3p PDGFRA -0.31101436822914 0.693407210545374 -0.145858107393819 0.902950557320272 mirMAP -0.516833762443087 0.000428514669277019 NA NA NA hsa-let-7g-3p PDGFRA -0.489638373791485 0.62941522205833 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.448281873669985 3.34960551496113e-08 NA NA NA hsa-miR-106a-5p PDGFRA -0.203919267842652 0.802213958426804 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.461331612749808 1.21459582544494e-06 NA NA NA hsa-miR-106b-5p PDGFRA -0.297128724729339 0.869294443540749 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.788405389096865 1.19973361815904e-13 NA NA NA hsa-miR-130b-3p PDGFRA -0.221667315324818 0.824660172394714 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.713055953049172 6.98352333830201e-14 NA NA NA hsa-miR-140-5p PDGFRA -0.229213026275906 0.847330111738616 -0.145858107393819 0.902950557320272 miRNAWalker2_validate;miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.378645948787408 0.00817849787504184 26297547 miR 140 5p inhibits ovarian cancer growth partially by repression of PDGFRA; Additionally PDGFRA was predicted the target gene of miR-140-5p; PDGFRA was inversely correlated with the expression of miR-140-5p in ovarian cancer cells ovarian cancer hsa-miR-141-3p PDGFRA -0.31994058840327 0.87774106909065 -0.145858107393819 0.902950557320272 MirTarget -0.558254342811311 1.59735147532957e-12 NA NA NA hsa-miR-16-1-3p PDGFRA 0.151694812889216 0.733736501874638 -0.145858107393819 0.902950557320272 MirTarget -0.391474995802884 3.72447068651333e-06 NA NA NA hsa-miR-17-5p PDGFRA -0.175448849583061 0.934544015912731 -0.145858107393819 0.902950557320272 MirTarget;TargetScan;miRNATAP -0.500899724208041 1.35275307087739e-09 NA NA NA hsa-miR-182-5p PDGFRA -0.104238497940557 0.973380614062243 -0.145858107393819 0.902950557320272 miRNATAP -0.351343598684222 3.64495302642716e-05 NA NA NA hsa-miR-186-5p PDGFRA -0.318786974828757 0.85412722938961 -0.145858107393819 0.902950557320272 MirTarget -0.680532199603127 4.02581457439773e-07 NA NA NA hsa-miR-193a-3p PDGFRA -0.247265785363732 0.654363581941634 -0.145858107393819 0.902950557320272 miRanda -0.308129712347872 0.000729810331533374 NA NA NA hsa-miR-196a-5p PDGFRA -0.0569856738232488 0.973093117800687 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.226717073924458 7.8971760883461e-05 NA NA NA hsa-miR-200a-3p PDGFRA -0.367034437440907 0.851059894150266 -0.145858107393819 0.902950557320272 MirTarget -0.414102446036165 1.51743336403368e-07 NA NA NA hsa-miR-20a-5p PDGFRA -0.179153323927949 0.928118119139752 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.403163295382866 1.05772983131811e-06 NA NA NA hsa-miR-2110 PDGFRA -0.317803483266315 0.250981343062022 -0.145858107393819 0.902950557320272 MirTarget -0.366181032284536 9.44460298164708e-05 NA NA NA hsa-miR-26b-5p PDGFRA -0.0245931278499594 0.990377966314923 -0.145858107393819 0.902950557320272 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.76554214258799 1.34342011356511e-09 NA NA NA hsa-miR-27a-3p PDGFRA -0.123902317731458 0.958804393510999 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.516042216303154 0.000914778337518972 NA NA NA hsa-miR-29a-3p PDGFRA 0.01127474410284 0.996977020481272 -0.145858107393819 0.902950557320272 MirTarget -0.809568799779591 4.96242330696496e-11 NA NA NA hsa-miR-29b-1-5p PDGFRA -0.642348119412534 0.293891497238796 -0.145858107393819 0.902950557320272 mirMAP -0.425193514964668 2.19115837746288e-10 NA NA NA hsa-miR-29b-3p PDGFRA -0.104016192263954 0.958988036765397 -0.145858107393819 0.902950557320272 MirTarget -0.70477380352231 1.49237333469501e-14 NA NA NA hsa-miR-301a-3p PDGFRA -0.105312511901769 0.831686745977347 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.397818747734378 1.84518884433226e-06 NA NA NA hsa-miR-320b PDGFRA -0.23561798088153 0.859222532827992 -0.145858107393819 0.902950557320272 miRanda -0.271817768499418 0.00931638762599068 NA NA NA hsa-miR-335-3p PDGFRA -0.244830745789445 0.88450019116631 -0.145858107393819 0.902950557320272 mirMAP -0.35160587390058 6.70186373595121e-05 NA NA NA hsa-miR-339-5p PDGFRA -0.300425087100667 0.712912847076788 -0.145858107393819 0.902950557320272 miRanda -0.457485269989944 3.66341806935034e-09 NA NA NA hsa-miR-33a-5p PDGFRA -0.205788753603336 0.853314500865147 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.272405442549699 1.25878366881518e-07 NA NA NA hsa-miR-33b-5p PDGFRA -0.161971614375297 0.737436207821109 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.351193123166394 4.89573526569498e-10 NA NA NA hsa-miR-34a-5p PDGFRA -0.50188164870224 0.742034237185732 -0.145858107393819 0.902950557320272 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.293946617803388 0.00483203526840856 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-362-3p PDGFRA -0.721040238345347 0.0345881362485733 -0.145858107393819 0.902950557320272 miRanda -0.331137641396915 2.44365531587286e-05 NA NA NA hsa-miR-374b-5p PDGFRA -0.285682091626878 0.83569830479965 -0.145858107393819 0.902950557320272 mirMAP -0.489332532273884 0.000275322473260306 NA NA NA hsa-miR-421 PDGFRA -0.182032017078616 0.734704500318599 -0.145858107393819 0.902950557320272 PITA;miRanda;miRNATAP -0.331972101032041 0.000352331324069819 NA NA NA hsa-miR-429 PDGFRA -0.456485631615963 0.806240953400535 -0.145858107393819 0.902950557320272 miRanda;miRNATAP -0.427308243384876 1.22907424761067e-08 NA NA NA hsa-miR-454-3p PDGFRA -0.101514866328011 0.843545158256191 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.526182378920795 4.63430277666318e-06 NA NA NA hsa-miR-550a-5p PDGFRA -0.390865630073894 0.535659273352227 -0.145858107393819 0.902950557320272 MirTarget -0.303957080101116 0.000421501403265132 NA NA NA hsa-miR-576-5p PDGFRA -0.506413219377403 0.417187951364173 -0.145858107393819 0.902950557320272 mirMAP -0.53161391653101 2.34508916321778e-08 NA NA NA hsa-miR-589-3p PDGFRA -0.835836305204965 0.0112001563801511 -0.145858107393819 0.902950557320272 mirMAP -0.324416945059502 1.4854980540892e-05 NA NA NA hsa-miR-590-3p PDGFRA -0.279244755376859 0.59126669933662 -0.145858107393819 0.902950557320272 miRanda;mirMAP -0.505584545520693 1.12850394310824e-10 NA NA NA hsa-miR-590-5p PDGFRA -0.547819833829572 0.472735645776647 -0.145858107393819 0.902950557320272 miRanda -0.618116353853085 3.24347610137224e-14 NA NA NA hsa-miR-642a-5p PDGFRA 0.00605485088835034 0.98806034007652 -0.145858107393819 0.902950557320272 MirTarget -0.215832054890106 0.000746473138697964 NA NA NA hsa-miR-7-1-3p PDGFRA -0.462485777435991 0.665899751398166 -0.145858107393819 0.902950557320272 mirMAP -0.523812035758304 1.699078163408e-08 NA NA NA hsa-miR-93-5p PDGFRA -0.611073677204699 0.825297877093193 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.562179024434523 5.29517125454282e-08 NA NA NA hsa-miR-96-5p PDGFRA 0.0854810872029343 0.923087820185031 -0.145858107393819 0.902950557320272 TargetScan;miRNATAP -0.531895407762512 3.58063096797815e-11 NA NA NA hsa-miR-224-5p PDGFRB -0.240425158977724 0.857351098476517 0.269735385981489 0.859643412257275 miRNAWalker2_validate -0.167596299133301 0.00451959282563429 NA NA NA hsa-miR-24-3p PDGFRB -0.0484778924256624 0.985274054814493 0.269735385981489 0.859643412257275 MirTarget -0.497348994016324 0.00212455415626555 NA NA NA hsa-miR-29a-3p PDGFRB 0.01127474410284 0.996977020481272 0.269735385981489 0.859643412257275 miRNATAP -0.749182849370106 8.28046458679609e-14 NA NA NA hsa-miR-29b-3p PDGFRB -0.104016192263954 0.958988036765397 0.269735385981489 0.859643412257275 miRNATAP -0.585510495081087 9.96403642896333e-15 NA NA NA hsa-miR-421 PDGFRB -0.182032017078616 0.734704500318599 0.269735385981489 0.859643412257275 miRanda -0.362666739511917 1.74841862274672e-06 NA NA NA hsa-miR-484 PDGFRB -0.179977202691249 0.886333755572375 0.269735385981489 0.859643412257275 mirMAP -0.538053678604706 4.36179283359931e-08 NA NA NA hsa-miR-361-5p PLA2G2A -0.138735309928775 0.941495130308343 -0.893929415091853 0.558555484830263 miRanda -1.88892274433189 8.28724293014527e-07 NA NA NA hsa-miR-542-3p PLA2G2D 0.188168046511374 0.909252939431573 -0.568038143383523 0.451587568296858 mirMAP -0.710465301036333 0.00357884264533144 NA NA NA hsa-miR-335-5p PLA2G2F -0.0284895175847679 0.973380867832231 0.308872685548984 0.755109764116244 mirMAP -0.509123839894343 0.00467705099258117 NA NA NA hsa-miR-452-3p PLA2G3 -0.167134177977311 0.799008246175244 -1.01702523712827 0.30431111054657 MirTarget -0.505412307982113 0.00504840689182451 NA NA NA hsa-miR-98-5p PLA2G3 -0.168162186023221 0.898802461503524 -1.01702523712827 0.30431111054657 MirTarget -0.899412333243839 0.00914875866125122 NA NA NA hsa-miR-181c-5p PLA2G4A 0.042951891660695 0.969159991881861 -0.17795678003461 0.817238494646462 MirTarget -0.578532695174483 0.000615603310862364 NA NA NA hsa-miR-181d-5p PLA2G4A 0.14926527647499 0.888000971478017 -0.17795678003461 0.817238494646462 MirTarget -0.564246660185543 1.7559415649798e-05 NA NA NA hsa-miR-361-5p PLA2G4A -0.138735309928775 0.941495130308343 -0.17795678003461 0.817238494646462 miRanda -1.29289456265609 1.70051078235766e-06 NA NA NA hsa-miR-362-3p PLA2G4A -0.721040238345347 0.0345881362485733 -0.17795678003461 0.817238494646462 miRanda -0.387724288667359 0.00326532186695987 NA NA NA hsa-miR-374a-5p PLA2G4A -0.343007247142618 0.766921280269271 -0.17795678003461 0.817238494646462 mirMAP -1.25811294976854 2.63713185547972e-08 NA NA NA hsa-miR-374b-5p PLA2G4A -0.285682091626878 0.83569830479965 -0.17795678003461 0.817238494646462 mirMAP -1.09437721975642 7.17405856968019e-07 NA NA NA hsa-miR-128-3p PLA2G5 -0.442192625156042 0.783886533572187 0.437718131121004 0.388965933347537 miRNAWalker2_validate -1.07299221212294 1.5853171740956e-12 NA NA NA hsa-miR-330-5p PLA2G5 -0.283418953659271 0.815687101334695 0.437718131121004 0.388965933347537 miRanda -0.482332053855329 0.00283741833706521 NA NA NA hsa-miR-339-5p PLA2G5 -0.300425087100667 0.712912847076788 0.437718131121004 0.388965933347537 miRanda -0.568708478983702 7.27136745248125e-09 NA NA NA hsa-miR-361-5p PLA2G5 -0.138735309928775 0.941495130308343 0.437718131121004 0.388965933347537 miRanda -0.730869197957008 0.000446179208994754 NA NA NA hsa-miR-429 PLA2G5 -0.456485631615963 0.806240953400535 0.437718131121004 0.388965933347537 miRanda -0.864714773103646 1.88119901673923e-22 NA NA NA hsa-miR-589-3p PLA2G5 -0.835836305204965 0.0112001563801511 0.437718131121004 0.388965933347537 MirTarget -0.558011063524848 1.97396961165042e-09 NA NA NA hsa-miR-590-3p PLA2G5 -0.279244755376859 0.59126669933662 0.437718131121004 0.388965933347537 miRanda;miRNATAP -0.845281063909192 7.33272044028014e-19 NA NA NA hsa-miR-590-5p PLA2G5 -0.547819833829572 0.472735645776647 0.437718131121004 0.388965933347537 miRanda -0.89773159614219 4.81957599780374e-19 NA NA NA hsa-miR-30a-3p PLA2G6 0.250338313897394 0.917094926793447 -0.0643225595335317 0.939085094960597 miRNATAP -0.180417635243828 0.00653370893089679 NA NA NA hsa-miR-214-5p PPM1A 0.056229650193357 0.945594330093021 -0.170587740374974 0.899428780567369 miRNATAP -0.119905543656529 5.40372628588268e-06 NA NA NA hsa-miR-23a-3p PPM1A -0.122198715333656 0.962717452143511 -0.170587740374974 0.899428780567369 mirMAP -0.203265446932236 3.73193640563969e-05 NA NA NA hsa-miR-17-5p PPP3CA -0.175448849583061 0.934544015912731 -0.087509752034574 0.946989676888573 miRNATAP -0.109137738299345 0.000214467204408686 NA NA NA hsa-miR-29a-5p PPP3CA -0.31835175571979 0.600442757817281 -0.087509752034574 0.946989676888573 mirMAP;miRNATAP -0.110664225522305 0.000326600214856183 NA NA NA hsa-miR-335-3p PPP3CA -0.244830745789445 0.88450019116631 -0.087509752034574 0.946989676888573 MirTarget -0.158993670541163 1.48991898684692e-07 NA NA NA hsa-miR-361-5p PPP3CA -0.138735309928775 0.941495130308343 -0.087509752034574 0.946989676888573 miRanda -0.181593940934707 0.00153602268336464 NA NA NA hsa-miR-374b-3p PPP3CA -0.0542885924440247 0.860753623992354 -0.087509752034574 0.946989676888573 MirTarget -0.118414724128426 0.00147351846810998 NA NA NA hsa-miR-361-5p PPP3CB -0.138735309928775 0.941495130308343 0.124829671662728 0.918408096293941 miRanda -0.192230575391786 6.63676765547426e-06 NA NA NA hsa-miR-421 PPP3CB -0.182032017078616 0.734704500318599 0.124829671662728 0.918408096293941 miRanda -0.101890409493066 2.52334802788457e-05 NA NA NA hsa-miR-375 PPP3CC -0.690952835064582 0.831716365337668 -0.156394846840244 0.838706340015868 miRanda -0.115145516987059 0.000311412501063658 NA NA NA hsa-miR-500a-3p PPP3CC -0.633375813338735 0.732582832733155 -0.156394846840244 0.838706340015868 MirTarget;miRNATAP -0.139392380696939 0.00623176129399307 NA NA NA hsa-miR-143-5p PPP3R1 0.10589969923845 0.933358732923556 -0.0496199114529308 0.972488514207793 miRNATAP -0.101757134766809 6.67106697655597e-08 NA NA NA hsa-miR-27b-3p PPP3R1 -0.14277121795778 0.951937409841932 -0.0496199114529308 0.972488514207793 miRNATAP -0.108860558741904 0.00403865953676784 NA NA NA hsa-miR-126-5p PRKACB 0.0815213541035824 0.956637332055185 0.143826955266481 0.908097519021419 mirMAP -0.368751851213397 0.00120348231579359 NA NA NA hsa-miR-146b-5p PRKACB -0.402662509440887 0.837510937985091 0.143826955266481 0.908097519021419 miRanda -0.384839282045274 0.000123624033577825 NA NA NA hsa-miR-16-2-3p PRKACB -0.36717860153421 0.546850726070016 0.143826955266481 0.908097519021419 mirMAP -0.327254668787011 5.02396526650647e-05 NA NA NA hsa-miR-18a-5p PRKACB -0.498318455303917 0.61264091975585 0.143826955266481 0.908097519021419 miRNATAP -0.245987058818593 0.000136929122339416 NA NA NA hsa-miR-18b-5p PRKACB -0.0473300652227538 0.899981261531446 0.143826955266481 0.908097519021419 miRNATAP -0.219595347623136 0.000526621294339559 NA NA NA hsa-miR-19a-3p PRKACB -0.206793507801887 0.844637784802316 0.143826955266481 0.908097519021419 MirTarget;miRNATAP -0.207051001728292 0.00506627328237604 NA NA NA hsa-miR-32-3p PRKACB -0.568003960723004 0.13133163420273 0.143826955266481 0.908097519021419 mirMAP;miRNATAP -0.203540155235648 0.00148647674126439 NA NA NA hsa-miR-577 PRKACB -1.06238199218774 0.326056761787754 0.143826955266481 0.908097519021419 PITA -0.156719343600752 0.000649809465517546 NA NA NA hsa-miR-582-5p PRKACB -0.399450205475138 0.581227478860085 0.143826955266481 0.908097519021419 MirTarget;PITA;miRNATAP -0.435642871850008 4.26493780643228e-06 NA NA NA hsa-miR-590-3p PRKACB -0.279244755376859 0.59126669933662 0.143826955266481 0.908097519021419 MirTarget;PITA;miRanda;miRNATAP -0.287824756359109 8.97202997356946e-05 NA NA NA hsa-miR-590-5p PRKACB -0.547819833829572 0.472735645776647 0.143826955266481 0.908097519021419 miRanda -0.269757804036837 0.000543621862271192 NA NA NA hsa-miR-7-1-3p PRKACB -0.462485777435991 0.665899751398166 0.143826955266481 0.908097519021419 mirMAP -0.347600791347028 5.3123112509601e-05 NA NA NA hsa-miR-29a-5p PRKCA -0.31835175571979 0.600442757817281 0.0560239871270882 0.96439442241644 mirMAP -0.131495002018621 0.00519611005738431 NA NA NA hsa-miR-450b-5p PRKCA -0.0136687538973108 0.983149761399849 0.0560239871270882 0.96439442241644 PITA;mirMAP;miRNATAP -0.165403673620787 0.00202940790109251 NA NA NA hsa-miR-141-5p PRKCB -0.354590233549885 0.867642456336402 -0.289166762598654 0.629896233011357 mirMAP -0.566149586465332 2.81537724392599e-08 NA NA NA hsa-miR-148a-5p PRKCB -0.448099743845604 0.748419139652266 -0.289166762598654 0.629896233011357 mirMAP -0.431607663118204 0.00014113366592115 NA NA NA hsa-miR-16-2-3p PRKCB -0.36717860153421 0.546850726070016 -0.289166762598654 0.629896233011357 mirMAP -0.556524355024035 7.09185137143842e-08 NA NA NA hsa-miR-186-5p PRKCB -0.318786974828757 0.85412722938961 -0.289166762598654 0.629896233011357 mirMAP -0.693684359345577 1.42561623028323e-05 NA NA NA hsa-miR-194-5p PRKCB -0.159001168846464 0.959682382557336 -0.289166762598654 0.629896233011357 miRNATAP -0.642313551381144 2.93325886945843e-10 NA NA NA hsa-miR-200b-3p PRKCB -0.426401948379212 0.863957108574195 -0.289166762598654 0.629896233011357 MirTarget -0.72108199701521 2.3659342346039e-11 NA NA NA hsa-miR-200c-3p PRKCB -0.437282635857873 0.887118598436407 -0.289166762598654 0.629896233011357 MirTarget;miRNATAP -0.752138899288806 1.18209268005294e-11 NA NA NA hsa-miR-23a-3p PRKCB -0.122198715333656 0.962717452143511 -0.289166762598654 0.629896233011357 mirMAP -0.972693790442231 3.83115244358293e-06 NA NA NA hsa-miR-24-3p PRKCB -0.0484778924256624 0.985274054814493 -0.289166762598654 0.629896233011357 miRNATAP -1.14917640884554 4.29809672564759e-07 NA NA NA hsa-miR-26b-5p PRKCB -0.0245931278499594 0.990377966314923 -0.289166762598654 0.629896233011357 mirMAP -0.759590158099125 4.96577614466636e-07 NA NA NA hsa-miR-27a-3p PRKCB -0.123902317731458 0.958804393510999 -0.289166762598654 0.629896233011357 MirTarget;miRNATAP -0.984191959979311 4.52942226692975e-08 NA NA NA hsa-miR-29a-5p PRKCB -0.31835175571979 0.600442757817281 -0.289166762598654 0.629896233011357 mirMAP -0.696324093556409 4.49269492269061e-12 NA NA NA hsa-miR-29b-1-5p PRKCB -0.642348119412534 0.293891497238796 -0.289166762598654 0.629896233011357 mirMAP -0.462740943974498 6.40796306307966e-09 NA NA NA hsa-miR-30b-5p PRKCB -0.0121430518253582 0.994622896704513 -0.289166762598654 0.629896233011357 mirMAP -0.662037641995433 1.55759802125021e-09 NA NA NA hsa-miR-30c-5p PRKCB -0.298383882401475 0.865809030482001 -0.289166762598654 0.629896233011357 mirMAP -0.651180444056476 5.12606576516922e-05 NA NA NA hsa-miR-30d-3p PRKCB -0.123474741320298 0.814905367625791 -0.289166762598654 0.629896233011357 mirMAP -0.66303716180293 1.26976276659109e-07 NA NA NA hsa-miR-30d-5p PRKCB -0.168211838771867 0.95173197030375 -0.289166762598654 0.629896233011357 mirMAP -0.584797855466169 5.33137646933608e-05 NA NA NA hsa-miR-335-3p PRKCB -0.244830745789445 0.88450019116631 -0.289166762598654 0.629896233011357 mirMAP -0.677283755988629 1.84838818790619e-11 NA NA NA hsa-miR-335-5p PRKCB -0.0284895175847679 0.973380867832231 -0.289166762598654 0.629896233011357 mirMAP -0.675730225781425 2.5572319841088e-11 NA NA NA hsa-miR-361-5p PRKCB -0.138735309928775 0.941495130308343 -0.289166762598654 0.629896233011357 MirTarget;miRanda;miRNATAP -0.865758986282353 6.88790498193778e-06 NA NA NA hsa-miR-429 PRKCB -0.456485631615963 0.806240953400535 -0.289166762598654 0.629896233011357 MirTarget;miRanda;miRNATAP -0.619682801567495 9.47055177854519e-13 NA NA NA hsa-miR-450b-5p PRKCB -0.0136687538973108 0.983149761399849 -0.289166762598654 0.629896233011357 miRNATAP -0.47287159382327 7.10615810748377e-05 NA NA NA hsa-miR-452-3p PRKCB -0.167134177977311 0.799008246175244 -0.289166762598654 0.629896233011357 mirMAP -0.513101429149364 6.7170941174423e-11 NA NA NA hsa-miR-484 PRKCB -0.179977202691249 0.886333755572375 -0.289166762598654 0.629896233011357 MirTarget;miRNATAP -0.612122177986842 1.70623299361676e-05 NA NA NA hsa-miR-491-5p PRKCB -0.585652105321328 0.0452620602586908 -0.289166762598654 0.629896233011357 miRanda -0.35090662989035 0.000620664439809745 NA NA NA hsa-miR-502-5p PRKCB -0.708507838520586 0.0261309781860104 -0.289166762598654 0.629896233011357 mirMAP -0.435593863435658 2.75280823982211e-06 NA NA NA hsa-miR-539-5p PRKCB 0.124342970087029 0.801067485473643 -0.289166762598654 0.629896233011357 mirMAP -0.432505044940763 0.00059746887984469 NA NA NA hsa-miR-589-3p PRKCB -0.835836305204965 0.0112001563801511 -0.289166762598654 0.629896233011357 mirMAP -0.335038959210738 0.00016508749914759 NA NA NA hsa-miR-589-5p PRKCB -0.448771545046784 0.722725226273464 -0.289166762598654 0.629896233011357 mirMAP -0.565653175638186 0.000328937511746594 NA NA NA hsa-miR-590-3p PRKCB -0.279244755376859 0.59126669933662 -0.289166762598654 0.629896233011357 mirMAP -0.422590592433378 8.43504361358025e-06 NA NA NA hsa-miR-590-5p PRKCB -0.547819833829572 0.472735645776647 -0.289166762598654 0.629896233011357 miRanda -0.600413375866668 1.04790649499024e-09 NA NA NA hsa-miR-7-1-3p PRKCB -0.462485777435991 0.665899751398166 -0.289166762598654 0.629896233011357 mirMAP -0.417430474142834 0.000191851900734184 NA NA NA hsa-miR-7-5p PRKCB 0.209645143210379 0.773705612298441 -0.289166762598654 0.629896233011357 MirTarget;miRNATAP -0.205730135642304 0.0042868075722764 NA NA NA hsa-miR-335-5p PTPN7 -0.0284895175847679 0.973380867832231 -0.971964426632788 0.2151182117863 miRNAWalker2_validate -0.438617897052232 2.78622076087644e-05 NA NA NA hsa-miR-195-5p PTPRR 0.343201952346823 0.749622318650888 0.472795677071144 0.53775682341456 MirTarget -0.372378095193192 0.00259493815924422 NA NA NA hsa-miR-217 PTPRR 0.341080669095094 0.760998144794468 0.472795677071144 0.53775682341456 miRanda -0.369074306229952 3.28276464205584e-05 NA NA NA hsa-miR-30a-3p PTPRR 0.250338313897394 0.917094926793447 0.472795677071144 0.53775682341456 MirTarget -0.496489327799733 0.00207080619040283 NA NA NA hsa-miR-30e-3p PTPRR -0.220498559176349 0.938660731870214 0.472795677071144 0.53775682341456 MirTarget -0.691531371349858 0.00168716013512382 NA NA NA hsa-miR-30c-2-3p RAC3 0.242912714924037 0.746927269997556 -0.189305936526801 0.723079466838889 miRNAWalker2_validate -0.284587404659289 0.00785701503311612 NA NA NA hsa-miR-19a-3p RAP1A -0.206793507801887 0.844637784802316 -0.110082502104731 0.934663978893337 MirTarget;miRNATAP -0.108944788434501 2.44713073021362e-06 NA NA NA hsa-miR-19b-3p RAP1A -0.0268530183621474 0.986656783046572 -0.110082502104731 0.934663978893337 MirTarget;miRNATAP -0.118776007635545 1.89944829990528e-05 NA NA NA hsa-miR-29a-5p RAP1A -0.31835175571979 0.600442757817281 -0.110082502104731 0.934663978893337 mirMAP -0.123144828542886 1.16978124618324e-06 NA NA NA hsa-miR-335-3p RAP1A -0.244830745789445 0.88450019116631 -0.110082502104731 0.934663978893337 mirMAP -0.119739493643969 2.31313425877955e-06 NA NA NA hsa-miR-539-5p RAP1A 0.124342970087029 0.801067485473643 -0.110082502104731 0.934663978893337 MirTarget;miRNATAP -0.123937631269248 5.48295403806522e-05 NA NA NA hsa-miR-92a-3p RAP1A 0.0278830870766349 0.993247426671713 -0.110082502104731 0.934663978893337 mirMAP;miRNATAP -0.156492439703989 3.32395854079154e-08 NA NA NA hsa-miR-101-3p RAP1B 0.0107754887734437 0.997036362636866 -0.0355605069345772 0.981492846834325 MirTarget;miRNATAP -0.221507424438491 1.25793937717131e-07 24697700 Functional analysis of miR 101 3p and Rap1b involved in hepatitis B virus related hepatocellular carcinoma pathogenesis; In this study we reported that HBV could repress miR-101-3p by inhibiting its promoter activity and identified the potential effects of miR-101-3p on some important biological properties of HCC cells by targeting Rap1b; Down-regulation of miR-101-3p promoted cell proliferation migration and reduced apoptosis and resulted in up-regulation of Rap1b while overexpression of miR-101-3p inhibited these processes; Moreover overexpression of Rap1b was able to reverse the suppressed cell proliferation and migration mediated by miR-101-3p; Our data showed that HBV down-regulated miR-101-3p expression by inhibiting its promoter activity which resulted in up-regulation of Rap1b and down-regulation of miR-101-3p or up-regulation of Rap1b promoted proliferation and migration of HCC cells liver cancer hsa-miR-101-5p RAP1B -0.27876696778882 0.558836382493107 -0.0355605069345772 0.981492846834325 MirTarget -0.132956879457368 1.70998872451677e-08 24697700 Functional analysis of miR 101 3p and Rap1b involved in hepatitis B virus related hepatocellular carcinoma pathogenesis liver cancer hsa-miR-181c-5p RAP1B 0.042951891660695 0.969159991881861 -0.0355605069345772 0.981492846834325 MirTarget;miRNATAP -0.113766940008307 0.000131137555874288 NA NA NA hsa-miR-19b-3p RAP1B -0.0268530183621474 0.986656783046572 -0.0355605069345772 0.981492846834325 MirTarget;miRNATAP -0.10301097686365 0.000278405572045985 NA NA NA hsa-miR-30e-5p RAP1B -0.0657075181381011 0.979684509181941 -0.0355605069345772 0.981492846834325 MirTarget -0.150708093051106 0.000701546039856641 NA NA NA hsa-miR-126-5p RAPGEF2 0.0815213541035824 0.956637332055185 0.0285543097402581 0.981757021515995 MirTarget;mirMAP -0.123287086435726 0.00450406565356472 NA NA NA hsa-miR-155-5p RAPGEF2 -0.407235807706004 0.828669616718496 0.0285543097402581 0.981757021515995 miRNAWalker2_validate;MirTarget -0.102251770395245 0.00207291059049159 NA NA NA hsa-miR-369-3p RAPGEF2 0.116576891957687 0.83230082995912 0.0285543097402581 0.981757021515995 MirTarget;PITA;miRNATAP -0.103835870668809 0.00262613762000253 NA NA NA hsa-miR-582-3p RAPGEF2 -0.2334649592375 0.897678119160318 0.0285543097402581 0.981757021515995 PITA;miRNATAP -0.155294479686888 8.27408412027404e-06 NA NA NA hsa-miR-590-3p RASA1 -0.279244755376859 0.59126669933662 0.215021777812651 0.867101665724599 miRanda -0.100209393151771 0.0016091969209744 NA NA NA hsa-miR-126-5p RASA2 0.0815213541035824 0.956637332055185 0.165463563857519 0.789603043878574 mirMAP -0.227482475101361 4.08857147389352e-05 NA NA NA hsa-miR-30b-5p RASA2 -0.0121430518253582 0.994622896704513 0.165463563857519 0.789603043878574 mirMAP -0.173633552700649 4.14391515700245e-05 NA NA NA hsa-miR-30c-5p RASA2 -0.298383882401475 0.865809030482001 0.165463563857519 0.789603043878574 mirMAP -0.174257070580333 0.00450024995864311 NA NA NA hsa-miR-374b-5p RASA2 -0.285682091626878 0.83569830479965 0.165463563857519 0.789603043878574 mirMAP -0.194793699666533 0.00122135462011673 NA NA NA hsa-miR-590-3p RASA2 -0.279244755376859 0.59126669933662 0.165463563857519 0.789603043878574 mirMAP -0.124980383206198 0.000551181349839643 NA NA NA hsa-let-7a-3p RASGRF2 -0.215598045625677 0.85543299203799 0.311212456313648 0.572114180174089 mirMAP -0.28208123010843 0.00318414737558839 NA NA NA hsa-miR-106a-5p RASGRF2 -0.203919267842652 0.802213958426804 0.311212456313648 0.572114180174089 MirTarget -0.319451020244955 0.000175380922127387 NA NA NA hsa-miR-106b-5p RASGRF2 -0.297128724729339 0.869294443540749 0.311212456313648 0.572114180174089 MirTarget -0.470801946449999 1.40014164959058e-06 NA NA NA hsa-miR-17-5p RASGRF2 -0.175448849583061 0.934544015912731 0.311212456313648 0.572114180174089 MirTarget;TargetScan -0.31257473210719 2.95587250698283e-05 NA NA NA hsa-miR-20a-5p RASGRF2 -0.179153323927949 0.928118119139752 0.311212456313648 0.572114180174089 MirTarget -0.257760692785249 0.000511086767535332 NA NA NA hsa-miR-30d-3p RASGRF2 -0.123474741320298 0.814905367625791 0.311212456313648 0.572114180174089 mirMAP -0.381418983283036 6.4191136467502e-05 NA NA NA hsa-miR-421 RASGRF2 -0.182032017078616 0.734704500318599 0.311212456313648 0.572114180174089 miRanda;mirMAP -0.235273941574404 0.00447281020108419 NA NA NA hsa-miR-429 RASGRF2 -0.456485631615963 0.806240953400535 0.311212456313648 0.572114180174089 miRanda -0.278228357074767 3.91157033483491e-05 NA NA NA hsa-miR-548o-3p RASGRF2 -0.191447572716994 0.517725546183501 0.311212456313648 0.572114180174089 mirMAP -0.272795500205695 0.000518960379802912 NA NA NA hsa-miR-590-3p RASGRF2 -0.279244755376859 0.59126669933662 0.311212456313648 0.572114180174089 MirTarget;miRanda -0.192732544282602 0.00761336990272499 NA NA NA hsa-miR-590-5p RASGRF2 -0.547819833829572 0.472735645776647 0.311212456313648 0.572114180174089 miRanda -0.258672488025639 0.000662870014943329 NA NA NA hsa-miR-93-5p RASGRF2 -0.611073677204699 0.825297877093193 0.311212456313648 0.572114180174089 MirTarget -0.27164204411933 0.00377079585422263 NA NA NA hsa-miR-135b-3p RASGRP1 0.0147512394776733 0.969435415142768 -0.880190878481172 0.0505475345286302 MirTarget -0.235695387126061 0.000223917471151014 NA NA NA hsa-miR-17-3p RASGRP1 0.100221625453134 0.960113387014848 -0.880190878481172 0.0505475345286302 MirTarget -0.280140752107922 0.00302143560347656 NA NA NA hsa-miR-196a-5p RASGRP1 -0.0569856738232488 0.973093117800687 -0.880190878481172 0.0505475345286302 MirTarget;miRNATAP -0.168935124065029 0.00210109998518396 NA NA NA hsa-miR-196b-5p RASGRP1 -0.0840912027031901 0.972112413910242 -0.880190878481172 0.0505475345286302 MirTarget;miRNATAP -0.231438319843541 1.22787828672472e-05 NA NA NA hsa-miR-335-5p RASGRP1 -0.0284895175847679 0.973380867832231 -0.880190878481172 0.0505475345286302 miRNAWalker2_validate -0.46272725902458 2.17122351953388e-08 NA NA NA hsa-miR-429 RASGRP1 -0.456485631615963 0.806240953400535 -0.880190878481172 0.0505475345286302 miRanda -0.266958219546344 0.000245088973922056 NA NA NA hsa-miR-452-5p RASGRP1 -0.0504626418153507 0.973874641360401 -0.880190878481172 0.0505475345286302 MirTarget -0.259451519342612 0.00359364374682818 NA NA NA hsa-miR-590-5p RASGRP1 -0.547819833829572 0.472735645776647 -0.880190878481172 0.0505475345286302 MirTarget;PITA;miRanda;miRNATAP -0.239344851743249 0.00339966068600183 NA NA NA hsa-miR-98-5p RASGRP1 -0.168162186023221 0.898802461503524 -0.880190878481172 0.0505475345286302 MirTarget -0.393283603173063 0.00171055465985574 NA NA NA hsa-miR-324-3p RASGRP2 -0.424387380347173 0.661528309116338 -0.139328052626859 0.745732729821851 PITA -0.416147559442335 0.00107032225354736 NA NA NA hsa-miR-484 RASGRP2 -0.179977202691249 0.886333755572375 -0.139328052626859 0.745732729821851 PITA -0.452835619989423 0.000500703074371668 NA NA NA hsa-miR-940 RASGRP2 -0.225788347550697 0.680055767105815 -0.139328052626859 0.745732729821851 MirTarget;PITA;miRNATAP -0.250739632540125 0.000765703616105639 NA NA NA hsa-miR-320a RASGRP3 -0.416546433767628 0.840202138616422 0.150983045514593 0.817693561351607 miRanda -0.250683668001994 0.00176057255260304 NA NA NA hsa-miR-324-3p RASGRP3 -0.424387380347173 0.661528309116338 0.150983045514593 0.817693561351607 MirTarget -0.221435212427347 0.00713652020206053 NA NA NA hsa-miR-339-5p RASGRP3 -0.300425087100667 0.712912847076788 0.150983045514593 0.817693561351607 miRanda -0.330175542150378 6.13678552903612e-10 NA NA NA hsa-miR-362-3p RASGRP3 -0.721040238345347 0.0345881362485733 0.150983045514593 0.817693561351607 miRanda -0.21281358143254 9.03646264528514e-05 NA NA NA hsa-miR-590-5p RASGRP3 -0.547819833829572 0.472735645776647 0.150983045514593 0.817693561351607 miRanda -0.333701005351422 7.75357318321857e-09 NA NA NA hsa-miR-7-1-3p RASGRP3 -0.462485777435991 0.665899751398166 0.150983045514593 0.817693561351607 mirMAP -0.248174780369912 0.000148598901996924 NA NA NA hsa-miR-1275 RASGRP4 -0.831342050607648 0.0803795852164229 -0.19645646116476 0.636382399011337 MirTarget -0.290074813600451 5.487239434527e-06 NA NA NA hsa-miR-135b-3p RASGRP4 0.0147512394776733 0.969435415142768 -0.19645646116476 0.636382399011337 MirTarget -0.192831186048658 0.00690426081434629 NA NA NA hsa-miR-30b-3p RASGRP4 -0.514644352757504 0.162424853398397 -0.19645646116476 0.636382399011337 MirTarget -0.417705543365615 2.31278949257711e-05 NA NA NA hsa-miR-34a-5p RASGRP4 -0.50188164870224 0.742034237185732 -0.19645646116476 0.636382399011337 MirTarget -0.299229491587927 0.00652353901993204 NA NA NA hsa-miR-577 RASGRP4 -1.06238199218774 0.326056761787754 -0.19645646116476 0.636382399011337 miRNATAP -0.237381595432657 6.66093594627961e-06 NA NA NA hsa-miR-625-5p RASGRP4 -0.690759472145277 0.210306534567564 -0.19645646116476 0.636382399011337 MirTarget -0.248407251271582 0.000957235219227392 NA NA NA hsa-miR-125b-5p RPS6KA1 0.042694645848468 0.980586836124662 -0.180208240744431 0.910162855344547 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.104692452263428 0.00316337364320319 NA NA NA hsa-miR-130b-5p RPS6KA2 -0.6472141103776 0.379096015222509 0.144949586958258 0.897031262142436 mirMAP -0.237129844458253 4.28134622117221e-05 NA NA NA hsa-miR-17-5p RPS6KA2 -0.175448849583061 0.934544015912731 0.144949586958258 0.897031262142436 TargetScan -0.322091991246309 2.68236808023537e-10 NA NA NA hsa-miR-192-3p RPS6KA2 -0.182835023264086 0.910241598161436 0.144949586958258 0.897031262142436 mirMAP -0.21084870860232 5.23989178637473e-05 NA NA NA hsa-miR-19a-3p RPS6KA2 -0.206793507801887 0.844637784802316 0.144949586958258 0.897031262142436 MirTarget -0.219108480961429 9.99020555334909e-06 NA NA NA hsa-miR-19b-3p RPS6KA2 -0.0268530183621474 0.986656783046572 0.144949586958258 0.897031262142436 MirTarget -0.23593272770493 7.51165325179059e-05 NA NA NA hsa-miR-200b-3p RPS6KA2 -0.426401948379212 0.863957108574195 0.144949586958258 0.897031262142436 TargetScan -0.194019240910741 0.000960143019653143 NA NA NA hsa-miR-200c-3p RPS6KA2 -0.437282635857873 0.887118598436407 0.144949586958258 0.897031262142436 miRNATAP -0.282574345530705 2.19834143913116e-06 NA NA NA hsa-miR-21-3p RPS6KA2 -0.395016549347053 0.87819982773565 0.144949586958258 0.897031262142436 MirTarget -0.198665091022652 0.00573225230895362 NA NA NA hsa-miR-26b-5p RPS6KA2 -0.0245931278499594 0.990377966314923 0.144949586958258 0.897031262142436 miRNATAP -0.239424054062088 0.00300670275952105 NA NA NA hsa-miR-335-5p RPS6KA2 -0.0284895175847679 0.973380867832231 0.144949586958258 0.897031262142436 miRNAWalker2_validate -0.234060431596672 1.8691081521659e-05 NA NA NA hsa-miR-378a-3p RPS6KA2 -0.466787210598086 0.795055970353024 0.144949586958258 0.897031262142436 MirTarget -0.178789803986197 0.00761323264211398 NA NA NA hsa-miR-429 RPS6KA2 -0.456485631615963 0.806240953400535 0.144949586958258 0.897031262142436 miRanda;miRNATAP -0.206097726708926 1.23988984742847e-05 NA NA NA hsa-miR-532-3p RPS6KA2 -0.496590111092324 0.682889021782543 0.144949586958258 0.897031262142436 MirTarget;mirMAP -0.197693517146467 0.000256173580681376 NA NA NA hsa-miR-589-5p RPS6KA2 -0.448771545046784 0.722725226273464 0.144949586958258 0.897031262142436 mirMAP -0.382143397432093 2.9387875425604e-06 NA NA NA hsa-miR-592 RPS6KA2 -0.177670083168544 0.856226890424691 0.144949586958258 0.897031262142436 mirMAP -0.138240930675091 2.37329786569536e-08 NA NA NA hsa-miR-760 RPS6KA2 -0.669469782471462 0.0773517068284613 0.144949586958258 0.897031262142436 MirTarget -0.165249753535965 5.87948360312009e-05 NA NA NA hsa-miR-93-3p RPS6KA2 -0.438355548962673 0.549902689385444 0.144949586958258 0.897031262142436 MirTarget -0.166388356178872 0.00445122133838709 NA NA NA hsa-let-7e-5p RPS6KA3 0.211156073215582 0.922335699862928 -0.132215596573594 0.934041665284517 miRNATAP -0.220355153590709 0.000102788838680634 NA NA NA hsa-let-7i-5p RPS6KA3 -0.200792135853451 0.922018647874073 -0.132215596573594 0.934041665284517 miRNATAP -0.199518724584192 0.00392315137047489 NA NA NA hsa-miR-125a-3p RPS6KA3 0.14689780893708 0.724764670752407 -0.132215596573594 0.934041665284517 MirTarget;PITA;miRanda;miRNATAP -0.10120710222421 0.000787089789432113 NA NA NA hsa-miR-146b-3p RPS6KA3 -0.408862981477661 0.762520540478861 -0.132215596573594 0.934041665284517 PITA;miRNATAP -0.191905867063606 2.08615645935529e-06 NA NA NA hsa-miR-181a-5p RPS6KA3 0.0295101956318291 0.989325168350125 -0.132215596573594 0.934041665284517 MirTarget;mirMAP;miRNATAP -0.130560589538182 0.00470625225436748 NA NA NA hsa-miR-181b-5p RPS6KA3 0.155313039554487 0.930176779696506 -0.132215596573594 0.934041665284517 MirTarget;mirMAP;miRNATAP -0.135367016219692 0.00255263774172863 NA NA NA hsa-miR-330-5p RPS6KA3 -0.283418953659271 0.815687101334695 -0.132215596573594 0.934041665284517 PITA;miRanda;miRNATAP -0.176751040863203 0.000369813323194387 NA NA NA hsa-miR-130a-3p RPS6KA5 0.0910074087716906 0.929098200371948 -0.465408237303092 0.503489395990948 MirTarget -0.18661726757861 0.000846421818052027 NA NA NA hsa-miR-153-3p RPS6KA5 -0.503770982320954 0.306832928666904 -0.465408237303092 0.503489395990948 MirTarget -0.14809840800199 1.50984165494752e-05 NA NA NA hsa-miR-19b-3p RPS6KA5 -0.0268530183621474 0.986656783046572 -0.465408237303092 0.503489395990948 MirTarget -0.143570193679067 0.0079223372323324 NA NA NA hsa-miR-20a-3p RPS6KA5 0.456808229166028 0.57674056136504 -0.465408237303092 0.503489395990948 miRNATAP -0.136837656503418 0.000281075902152046 NA NA NA hsa-miR-23a-3p RPS6KA5 -0.122198715333656 0.962717452143511 -0.465408237303092 0.503489395990948 mirMAP -0.456623891679761 4.15241584603963e-06 NA NA NA hsa-miR-23b-3p RPS6KA5 -0.10822254818704 0.961352920317636 -0.465408237303092 0.503489395990948 mirMAP -0.293043286981837 0.00296094404442797 NA NA NA hsa-miR-27a-3p RPS6KA5 -0.123902317731458 0.958804393510999 -0.465408237303092 0.503489395990948 miRNAWalker2_validate;MirTarget;miRNATAP -0.347716634390306 5.35755287906588e-05 NA NA NA hsa-miR-27b-3p RPS6KA5 -0.14277121795778 0.951937409841932 -0.465408237303092 0.503489395990948 MirTarget;miRNATAP -0.260275106461194 0.00924658259713381 NA NA NA hsa-miR-664a-3p RPS6KA5 -0.00395670341813714 0.996119749372707 -0.465408237303092 0.503489395990948 MirTarget;mirMAP -0.340817072193885 3.03134390031345e-07 NA NA NA hsa-miR-15b-5p RPS6KA6 -0.272614787130877 0.87096541832188 0.856877810927554 0.266043006824704 MirTarget -0.811160863135549 0.000449723382487955 NA NA NA hsa-miR-16-5p RPS6KA6 0.0135949734723564 0.994476223855607 0.856877810927554 0.266043006824704 MirTarget -0.643861771198276 0.00545292888494857 NA NA NA hsa-miR-590-3p RPS6KA6 -0.279244755376859 0.59126669933662 0.856877810927554 0.266043006824704 MirTarget;miRanda;mirMAP;miRNATAP -0.459330490563038 0.00743580331786831 NA NA NA hsa-miR-1304-5p RRAS -0.497887681787993 0.163079003594721 0.304022511420579 0.817721463502104 MirTarget -0.121654938697186 0.000101970906172872 NA NA NA hsa-miR-1306-3p RRAS -0.685383378847264 0.0170881307035124 0.304022511420579 0.817721463502104 MirTarget -0.135128354086083 0.000394160107642822 NA NA NA hsa-miR-27a-3p SOS1 -0.123902317731458 0.958804393510999 -0.133663949462885 0.918709253182528 MirTarget;miRNATAP -0.128294784600539 0.000637917145382412 NA NA NA hsa-miR-369-3p SOS1 0.116576891957687 0.83230082995912 -0.133663949462885 0.918709253182528 miRNATAP -0.135959090885724 6.65395075102377e-09 NA NA NA hsa-miR-381-3p SOS1 0.0562600264188893 0.966895219811624 -0.133663949462885 0.918709253182528 MirTarget -0.100940916746464 0.00276528516676685 NA NA NA hsa-miR-130a-3p SOS2 0.0910074087716906 0.929098200371948 -0.0380982568268919 0.974772477648122 miRNATAP -0.106710417537474 0.00163707990890625 NA NA NA hsa-miR-146b-5p SOS2 -0.402662509440887 0.837510937985091 -0.0380982568268919 0.974772477648122 miRanda -0.166193413119417 6.48354241761314e-06 NA NA NA hsa-miR-154-5p SOS2 -0.058936877201993 0.864854818862396 -0.0380982568268919 0.974772477648122 miRNATAP -0.116649989146456 0.00011300613484555 NA NA NA hsa-miR-493-5p SOS2 0.229930075372342 0.731979520100109 -0.0380982568268919 0.974772477648122 miRNATAP -0.128957133953108 0.00138950642379943 NA NA NA hsa-miR-148b-3p SRF -0.202106692287125 0.911884960581838 0.101391884024132 0.944768009814423 mirMAP -0.167103906977865 5.29882781244855e-06 NA NA NA hsa-miR-1976 SRF -0.283448756688618 0.707004130216603 0.101391884024132 0.944768009814423 mirMAP -0.106100762704959 0.000305344570186304 NA NA NA hsa-miR-200b-3p SRF -0.426401948379212 0.863957108574195 0.101391884024132 0.944768009814423 TargetScan -0.110345228988462 7.33337570582253e-06 NA NA NA hsa-miR-200c-3p SRF -0.437282635857873 0.887118598436407 0.101391884024132 0.944768009814423 miRNATAP -0.108259527276711 1.99479965873559e-05 NA NA NA hsa-miR-140-5p STK3 -0.229213026275906 0.847330111738616 0.077640168106095 0.937669080858703 PITA;miRanda -0.227472584820125 6.12755675808099e-05 NA NA NA hsa-miR-511-5p STK3 -0.308591187445274 0.607200373476563 0.077640168106095 0.937669080858703 MirTarget -0.102637526214031 0.00259152101618287 NA NA NA hsa-miR-139-5p STMN1 -0.0810891026597322 0.928690377743652 -0.362962592461892 0.833262117285959 miRanda -0.131287192868642 0.00601576947484921 NA NA NA hsa-miR-30a-5p STMN1 0.219472325612346 0.933954023293816 -0.362962592461892 0.833262117285959 miRNAWalker2_validate -0.182771867554088 0.00990067312996087 NA NA NA hsa-let-7a-3p TAOK1 -0.215598045625677 0.85543299203799 -0.00511870860271202 0.995099673202883 MirTarget;miRNATAP -0.289186206275419 5.69874760925919e-06 NA NA NA hsa-let-7d-5p TAOK1 -0.139747701175051 0.934164162708487 -0.00511870860271202 0.995099673202883 miRNATAP -0.411113494529527 1.11237432606311e-05 NA NA NA hsa-let-7g-5p TAOK1 -0.200947212961157 0.922992045181955 -0.00511870860271202 0.995099673202883 miRNATAP -0.355452038942331 9.36640676316764e-05 NA NA NA hsa-miR-106b-5p TAOK1 -0.297128724729339 0.869294443540749 -0.00511870860271202 0.995099673202883 miRNATAP -0.389159417401526 2.1183263790512e-09 NA NA NA hsa-miR-126-5p TAOK1 0.0815213541035824 0.956637332055185 -0.00511870860271202 0.995099673202883 mirMAP;miRNATAP -0.254692227438769 0.000661454844093722 NA NA NA hsa-miR-130a-3p TAOK1 0.0910074087716906 0.929098200371948 -0.00511870860271202 0.995099673202883 mirMAP -0.251774776313971 2.47637269335975e-05 NA NA NA hsa-miR-130b-3p TAOK1 -0.221667315324818 0.824660172394714 -0.00511870860271202 0.995099673202883 mirMAP -0.33523166371452 9.88342146980717e-09 NA NA NA hsa-miR-130b-5p TAOK1 -0.6472141103776 0.379096015222509 -0.00511870860271202 0.995099673202883 mirMAP -0.193316558656321 0.000599870882890337 NA NA NA hsa-miR-140-5p TAOK1 -0.229213026275906 0.847330111738616 -0.00511870860271202 0.995099673202883 miRanda -0.369455850025258 1.23805391481558e-05 NA NA NA hsa-miR-148a-5p TAOK1 -0.448099743845604 0.748419139652266 -0.00511870860271202 0.995099673202883 mirMAP -0.154103781305374 0.00783013999521567 NA NA NA hsa-miR-154-5p TAOK1 -0.058936877201993 0.864854818862396 -0.00511870860271202 0.995099673202883 miRNATAP -0.14659417606057 0.00681411722084 NA NA NA hsa-miR-15a-5p TAOK1 -0.0674049094129128 0.964835434214123 -0.00511870860271202 0.995099673202883 MirTarget -0.236628721447117 0.000732119468120092 NA NA NA hsa-miR-15b-3p TAOK1 -0.557749208157585 0.609181305423188 -0.00511870860271202 0.995099673202883 mirMAP -0.158390264987686 0.00845757386688902 NA NA NA hsa-miR-15b-5p TAOK1 -0.272614787130877 0.87096541832188 -0.00511870860271202 0.995099673202883 MirTarget -0.221989669374855 0.000737982789565095 NA NA NA hsa-miR-16-5p TAOK1 0.0135949734723564 0.994476223855607 -0.00511870860271202 0.995099673202883 MirTarget;miRNATAP -0.332671522911601 2.46043079921819e-07 NA NA NA hsa-miR-17-5p TAOK1 -0.175448849583061 0.934544015912731 -0.00511870860271202 0.995099673202883 TargetScan;miRNATAP -0.165697564289553 0.00114292411038062 NA NA NA hsa-miR-18a-5p TAOK1 -0.498318455303917 0.61264091975585 -0.00511870860271202 0.995099673202883 MirTarget;miRNATAP -0.209401538140978 5.89018123156266e-07 NA NA NA hsa-miR-18b-5p TAOK1 -0.0473300652227538 0.899981261531446 -0.00511870860271202 0.995099673202883 MirTarget -0.216250986631897 1.25464110998807e-07 NA NA NA hsa-miR-193a-3p TAOK1 -0.247265785363732 0.654363581941634 -0.00511870860271202 0.995099673202883 MirTarget;miRNATAP -0.174952789564366 0.0013727005403012 NA NA NA hsa-miR-193b-3p TAOK1 0.0672068426635715 0.951480422273678 -0.00511870860271202 0.995099673202883 MirTarget;miRNATAP -0.222175457668889 3.61346238362073e-05 NA NA NA hsa-miR-197-3p TAOK1 -0.455489147957159 0.794916582095149 -0.00511870860271202 0.995099673202883 MirTarget;miRNATAP -0.183627962142203 0.00377481962740574 NA NA NA hsa-miR-19a-3p TAOK1 -0.206793507801887 0.844637784802316 -0.00511870860271202 0.995099673202883 MirTarget;miRNATAP -0.158239343244542 0.00108446210797006 NA NA NA hsa-miR-19b-3p TAOK1 -0.0268530183621474 0.986656783046572 -0.00511870860271202 0.995099673202883 MirTarget;miRNATAP -0.216888164930283 0.000170546393271837 NA NA NA hsa-miR-200b-3p TAOK1 -0.426401948379212 0.863957108574195 -0.00511870860271202 0.995099673202883 MirTarget;TargetScan;mirMAP -0.155300706908994 0.00645848596637814 NA NA NA hsa-miR-20a-5p TAOK1 -0.179153323927949 0.928118119139752 -0.00511870860271202 0.995099673202883 miRNATAP -0.131927498864795 0.00885588317254639 NA NA NA hsa-miR-214-3p TAOK1 0.198015895663265 0.797041683257943 -0.00511870860271202 0.995099673202883 miRNATAP -0.153301651842365 0.000394666108408034 NA NA NA hsa-miR-221-3p TAOK1 0.0906940388127513 0.959121118272534 -0.00511870860271202 0.995099673202883 miRNATAP -0.263601315670193 0.000230748550365852 NA NA NA hsa-miR-222-3p TAOK1 -0.0265849318772702 0.984005474689108 -0.00511870860271202 0.995099673202883 miRNATAP -0.268161371743201 2.59590762543185e-05 NA NA NA hsa-miR-24-3p TAOK1 -0.0484778924256624 0.985274054814493 -0.00511870860271202 0.995099673202883 MirTarget;miRNATAP -0.5355603184991 3.69943381353998e-06 NA NA NA hsa-miR-26a-1-3p TAOK1 -0.429875601809349 0.182136384322617 -0.00511870860271202 0.995099673202883 mirMAP -0.152556590349994 0.00228936361272281 NA NA NA hsa-miR-26a-2-3p TAOK1 -0.427772454814258 0.28776911697575 -0.00511870860271202 0.995099673202883 mirMAP -0.224810574114631 1.59459389185408e-05 NA NA NA hsa-miR-26a-5p TAOK1 0.00698202897993028 0.997719986197021 -0.00511870860271202 0.995099673202883 mirMAP;miRNATAP -0.367164158324421 0.00117136889793524 NA NA NA hsa-miR-26b-3p TAOK1 -0.363222538866814 0.681115126930068 -0.00511870860271202 0.995099673202883 mirMAP -0.243225517971086 4.91651730998688e-05 NA NA NA hsa-miR-26b-5p TAOK1 -0.0245931278499594 0.990377966314923 -0.00511870860271202 0.995099673202883 mirMAP;miRNATAP -0.460163667860578 1.126748567227e-09 NA NA NA hsa-miR-27a-3p TAOK1 -0.123902317731458 0.958804393510999 -0.00511870860271202 0.995099673202883 MirTarget -0.410310429189273 8.6503677261009e-06 NA NA NA hsa-miR-27b-3p TAOK1 -0.14277121795778 0.951937409841932 -0.00511870860271202 0.995099673202883 MirTarget -0.36474538999359 0.000650904572688232 NA NA NA hsa-miR-29a-3p TAOK1 0.01127474410284 0.996977020481272 -0.00511870860271202 0.995099673202883 mirMAP -0.367806022910915 1.05013012087767e-06 NA NA NA hsa-miR-29a-5p TAOK1 -0.31835175571979 0.600442757817281 -0.00511870860271202 0.995099673202883 mirMAP -0.224721756584483 2.00959592006198e-05 NA NA NA hsa-miR-30b-5p TAOK1 -0.0121430518253582 0.994622896704513 -0.00511870860271202 0.995099673202883 miRNAWalker2_validate;MirTarget -0.351824448090883 2.0099565820799e-10 NA NA NA hsa-miR-30c-5p TAOK1 -0.298383882401475 0.865809030482001 -0.00511870860271202 0.995099673202883 MirTarget;miRNATAP -0.396536925119649 9.15317546221844e-07 NA NA NA hsa-miR-32-3p TAOK1 -0.568003960723004 0.13133163420273 -0.00511870860271202 0.995099673202883 mirMAP -0.20992638562982 3.94297128416465e-07 NA NA NA hsa-miR-324-5p TAOK1 -0.50063248413014 0.537416710557032 -0.00511870860271202 0.995099673202883 miRanda -0.233806098189806 0.000128701699634591 NA NA NA hsa-miR-331-5p TAOK1 -0.450673082073933 0.250361590873666 -0.00511870860271202 0.995099673202883 mirMAP -0.191442230385576 0.00324370491564022 NA NA NA hsa-miR-339-5p TAOK1 -0.300425087100667 0.712912847076788 -0.00511870860271202 0.995099673202883 miRanda -0.306239123514282 2.58904388642134e-11 NA NA NA hsa-miR-33a-5p TAOK1 -0.205788753603336 0.853314500865147 -0.00511870860271202 0.995099673202883 mirMAP -0.109993068184433 0.000460365857051822 NA NA NA hsa-miR-33b-5p TAOK1 -0.161971614375297 0.737436207821109 -0.00511870860271202 0.995099673202883 mirMAP -0.104925340712668 0.0026639669933574 NA NA NA hsa-miR-340-5p TAOK1 -0.00276909425328853 0.99757361161055 -0.00511870860271202 0.995099673202883 mirMAP -0.181937868734999 0.0078733015077039 NA NA NA hsa-miR-362-3p TAOK1 -0.721040238345347 0.0345881362485733 -0.00511870860271202 0.995099673202883 miRanda -0.253441588166306 4.49762701258883e-08 NA NA NA hsa-miR-369-3p TAOK1 0.116576891957687 0.83230082995912 -0.00511870860271202 0.995099673202883 MirTarget;miRNATAP -0.305424851204669 1.78467830189005e-07 NA NA NA hsa-miR-374a-5p TAOK1 -0.343007247142618 0.766921280269271 -0.00511870860271202 0.995099673202883 mirMAP -0.264011800383466 0.0015385514327267 NA NA NA hsa-miR-374b-5p TAOK1 -0.285682091626878 0.83569830479965 -0.00511870860271202 0.995099673202883 mirMAP;miRNATAP -0.360952325786854 6.20050912195452e-06 NA NA NA hsa-miR-376b-3p TAOK1 -0.00712550627858333 0.982426403308526 -0.00511870860271202 0.995099673202883 mirMAP -0.221881896923438 8.37214680897164e-06 NA NA NA hsa-miR-376c-3p TAOK1 0.310149183310886 0.558689295035779 -0.00511870860271202 0.995099673202883 mirMAP -0.226277396661683 1.28769385638686e-05 NA NA NA hsa-miR-424-5p TAOK1 0.247080963500746 0.870154571783568 -0.00511870860271202 0.995099673202883 MirTarget -0.154309202573979 0.00152889573792349 NA NA NA hsa-miR-425-5p TAOK1 -0.354606074344121 0.845979106734409 -0.00511870860271202 0.995099673202883 miRNAWalker2_validate -0.22972866277421 1.37916046631797e-05 NA NA NA hsa-miR-429 TAOK1 -0.456485631615963 0.806240953400535 -0.00511870860271202 0.995099673202883 MirTarget;mirMAP;miRNATAP -0.18131194137485 7.41722528759786e-05 NA NA NA hsa-miR-495-3p TAOK1 0.00168200867117596 0.997533662527025 -0.00511870860271202 0.995099673202883 mirMAP -0.225681427543245 0.00214487043679526 NA NA NA hsa-miR-501-5p TAOK1 -0.834032628506285 0.0582725160418523 -0.00511870860271202 0.995099673202883 miRNATAP -0.13187030640954 0.00233873279729598 NA NA NA hsa-miR-502-5p TAOK1 -0.708507838520586 0.0261309781860104 -0.00511870860271202 0.995099673202883 miRNATAP -0.139409414183381 0.00354226186958432 NA NA NA hsa-miR-505-3p TAOK1 -0.469094267152605 0.690382680489578 -0.00511870860271202 0.995099673202883 mirMAP -0.275829000602018 7.49618305196837e-05 NA NA NA hsa-miR-576-5p TAOK1 -0.506413219377403 0.417187951364173 -0.00511870860271202 0.995099673202883 mirMAP -0.159317258311087 0.00648654397652538 NA NA NA hsa-miR-582-5p TAOK1 -0.399450205475138 0.581227478860085 -0.00511870860271202 0.995099673202883 MirTarget;miRNATAP -0.168899897226629 0.00762986924904412 NA NA NA hsa-miR-590-3p TAOK1 -0.279244755376859 0.59126669933662 -0.00511870860271202 0.995099673202883 miRanda;mirMAP -0.207079923942434 1.70514530402221e-05 NA NA NA hsa-miR-625-5p TAOK1 -0.690759472145277 0.210306534567564 -0.00511870860271202 0.995099673202883 MirTarget -0.185715696591985 1.13756943028614e-05 NA NA NA hsa-miR-655-3p TAOK1 0.225525683904601 0.432294495359122 -0.00511870860271202 0.995099673202883 MirTarget -0.222983476783455 0.000198688781895925 NA NA NA hsa-miR-96-5p TAOK1 0.0854810872029343 0.923087820185031 -0.00511870860271202 0.995099673202883 miRNAWalker2_validate;TargetScan;miRNATAP -0.262275109266194 8.16310203179911e-08 NA NA NA hsa-miR-144-3p TGFB1 0.0482420655617901 0.935871997593533 0.20606591055844 0.864135148758689 miRTarBase -0.158176126715838 0.000455981186321274 NA NA NA hsa-miR-29b-3p TGFB1 -0.104016192263954 0.958988036765397 0.20606591055844 0.864135148758689 miRTarBase -0.418904079644804 5.97577996681149e-09 NA NA NA hsa-let-7a-3p TGFB2 -0.215598045625677 0.85543299203799 0.566877582921754 0.302981050441313 miRNATAP -0.509553196595548 1.6994890144512e-07 NA NA NA hsa-miR-130b-3p TGFB2 -0.221667315324818 0.824660172394714 0.566877582921754 0.302981050441313 MirTarget;miRNATAP -0.484051596294314 8.89145164465726e-08 NA NA NA hsa-miR-141-3p TGFB2 -0.31994058840327 0.87774106909065 0.566877582921754 0.302981050441313 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.453055156957619 8.49592670640955e-10 NA NA NA hsa-miR-142-3p TGFB2 -0.154235241441331 0.946098054588918 0.566877582921754 0.302981050441313 miRNATAP -0.232355282039217 0.00153966616658786 NA NA NA hsa-miR-142-5p TGFB2 -0.118920788314118 0.929665277963083 0.566877582921754 0.302981050441313 mirMAP -0.219369115404822 0.00680504214547402 NA NA NA hsa-miR-148a-3p TGFB2 -0.101286586375016 0.976980454193186 0.566877582921754 0.302981050441313 MirTarget;miRNATAP -0.46318701252785 3.10804606849136e-07 NA NA NA hsa-miR-148b-3p TGFB2 -0.202106692287125 0.911884960581838 0.566877582921754 0.302981050441313 MirTarget -0.55651714764531 1.71955467385875e-05 NA NA NA hsa-miR-186-5p TGFB2 -0.318786974828757 0.85412722938961 0.566877582921754 0.302981050441313 mirMAP -0.658763474863498 9.43232781346235e-08 NA NA NA hsa-miR-193a-3p TGFB2 -0.247265785363732 0.654363581941634 0.566877582921754 0.302981050441313 MirTarget;miRanda;miRNATAP -0.240773694665901 0.00434002606348744 NA NA NA hsa-miR-200a-3p TGFB2 -0.367034437440907 0.851059894150266 0.566877582921754 0.302981050441313 MirTarget;miRNATAP -0.393177791645403 6.04013393821491e-08 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 -0.265248086637561 0.931593594361942 0.566877582921754 0.302981050441313 MirTarget -0.346567340811647 1.20313347637985e-07 NA NA NA hsa-miR-29a-3p TGFB2 0.01127474410284 0.996977020481272 0.566877582921754 0.302981050441313 MirTarget;miRNATAP -0.575630664666141 6.88773528918933e-07 NA NA NA hsa-miR-29b-3p TGFB2 -0.104016192263954 0.958988036765397 0.566877582921754 0.302981050441313 miRTarBase;MirTarget;miRNATAP -0.520150522000126 1.98301663290379e-09 NA NA NA hsa-miR-301a-3p TGFB2 -0.105312511901769 0.831686745977347 0.566877582921754 0.302981050441313 MirTarget;miRNATAP -0.27612545445948 0.000385597686723549 NA NA NA hsa-miR-32-3p TGFB2 -0.568003960723004 0.13133163420273 0.566877582921754 0.302981050441313 mirMAP -0.411501778912108 4.65513477983269e-11 NA NA NA hsa-miR-324-5p TGFB2 -0.50063248413014 0.537416710557032 0.566877582921754 0.302981050441313 miRanda -0.336340102670961 0.000359923455444418 NA NA NA hsa-miR-331-5p TGFB2 -0.450673082073933 0.250361590873666 0.566877582921754 0.302981050441313 miRNATAP -0.389505552306975 8.94731124077219e-05 NA NA NA hsa-miR-335-3p TGFB2 -0.244830745789445 0.88450019116631 0.566877582921754 0.302981050441313 mirMAP -0.413154502843607 2.72697980713492e-07 NA NA NA hsa-miR-335-5p TGFB2 -0.0284895175847679 0.973380867832231 0.566877582921754 0.302981050441313 miRNAWalker2_validate -0.409411679068793 3.98124076510825e-07 NA NA NA hsa-miR-33a-3p TGFB2 -0.794543849238581 0.0105203072007922 0.566877582921754 0.302981050441313 MirTarget;mirMAP -0.408250076739687 3.84332035251976e-08 NA NA NA hsa-miR-362-3p TGFB2 -0.721040238345347 0.0345881362485733 0.566877582921754 0.302981050441313 miRanda -0.355323991152597 7.48809298588997e-07 NA NA NA hsa-miR-362-5p TGFB2 -0.26647467080141 0.752024885130738 0.566877582921754 0.302981050441313 MirTarget -0.370650102758948 4.63810708635457e-08 NA NA NA hsa-miR-374a-5p TGFB2 -0.343007247142618 0.766921280269271 0.566877582921754 0.302981050441313 mirMAP -0.590082040242667 3.21665468463847e-06 NA NA NA hsa-miR-374b-5p TGFB2 -0.285682091626878 0.83569830479965 0.566877582921754 0.302981050441313 mirMAP -0.56445539974881 4.40383710254309e-06 NA NA NA hsa-miR-375 TGFB2 -0.690952835064582 0.831716365337668 0.566877582921754 0.302981050441313 miRNAWalker2_validate -0.202181245010158 0.00036513230561127 NA NA NA hsa-miR-429 TGFB2 -0.456485631615963 0.806240953400535 0.566877582921754 0.302981050441313 miRNATAP -0.403453846611381 5.10568073154813e-09 NA NA NA hsa-miR-454-3p TGFB2 -0.101514866328011 0.843545158256191 0.566877582921754 0.302981050441313 MirTarget;miRNATAP -0.415241866764752 9.8183646229735e-05 NA NA NA hsa-miR-500a-5p TGFB2 -0.71978560736831 0.188073776225276 0.566877582921754 0.302981050441313 mirMAP -0.337502696848928 8.62687089622154e-06 NA NA NA hsa-miR-589-3p TGFB2 -0.835836305204965 0.0112001563801511 0.566877582921754 0.302981050441313 MirTarget -0.31190425828218 6.04695289795267e-06 NA NA NA hsa-miR-590-3p TGFB2 -0.279244755376859 0.59126669933662 0.566877582921754 0.302981050441313 mirMAP -0.534073821286711 5.92202924180913e-14 NA NA NA hsa-miR-590-5p TGFB2 -0.547819833829572 0.472735645776647 0.566877582921754 0.302981050441313 miRanda;miRNATAP -0.517762991776137 9.79723846830351e-12 NA NA NA hsa-miR-7-5p TGFB2 0.209645143210379 0.773705612298441 0.566877582921754 0.302981050441313 MirTarget -0.223152315293427 6.21523733835928e-05 NA NA NA hsa-let-7a-3p TGFB3 -0.215598045625677 0.85543299203799 0.290973928352888 0.724980713991104 MirTarget -0.683864247335398 2.32084912745715e-08 NA NA NA hsa-let-7f-1-3p TGFB3 -0.31101436822914 0.693407210545374 0.290973928352888 0.724980713991104 MirTarget -0.920550529071741 3.76931882500923e-08 NA NA NA hsa-miR-10a-5p TGFB3 0.0740585720685925 0.983770933356406 0.290973928352888 0.724980713991104 miRNAWalker2_validate -0.598760473914115 1.53805553632417e-08 NA NA NA hsa-miR-151a-5p TGFB3 -0.416333535986492 0.695673384848773 0.290973928352888 0.724980713991104 MirTarget -0.80897372667275 3.51594518430166e-12 NA NA NA hsa-miR-26b-3p TGFB3 -0.363222538866814 0.681115126930068 0.290973928352888 0.724980713991104 MirTarget -0.634118114736644 3.1640342294488e-08 NA NA NA hsa-miR-29a-3p TGFB3 0.01127474410284 0.996977020481272 0.290973928352888 0.724980713991104 miRNAWalker2_validate -0.97578042792513 8.18301076737461e-12 NA NA NA hsa-miR-29b-3p TGFB3 -0.104016192263954 0.958988036765397 0.290973928352888 0.724980713991104 miRTarBase -0.778433510463803 4.28162839239473e-13 NA NA NA hsa-miR-590-3p TGFB3 -0.279244755376859 0.59126669933662 0.290973928352888 0.724980713991104 miRanda -0.694919331770113 7.31980174905473e-15 NA NA NA hsa-miR-629-3p TGFB3 -0.495402745812008 0.333967382214384 0.290973928352888 0.724980713991104 MirTarget -0.463502025717243 1.99571609951234e-07 NA NA NA hsa-let-7d-5p TGFBR1 -0.139747701175051 0.934164162708487 0.00124110995600457 0.999243914683908 miRNAWalker2_validate;miRNATAP -0.252351058932901 5.19637678255502e-05 NA NA NA hsa-let-7g-5p TGFBR1 -0.200947212961157 0.922992045181955 0.00124110995600457 0.999243914683908 miRNATAP -0.34840889225408 3.83895105938013e-09 NA NA NA hsa-miR-101-3p TGFBR1 0.0107754887734437 0.997036362636866 0.00124110995600457 0.999243914683908 miRNAWalker2_validate;miRNATAP -0.173310974451963 0.0027942913809115 NA NA NA hsa-miR-101-5p TGFBR1 -0.27876696778882 0.558836382493107 0.00124110995600457 0.999243914683908 mirMAP -0.103767014652861 0.00151301439591569 NA NA NA hsa-miR-126-5p TGFBR1 0.0815213541035824 0.956637332055185 0.00124110995600457 0.999243914683908 mirMAP;miRNATAP -0.152937595787177 0.00213879163817661 NA NA NA hsa-miR-128-3p TGFBR1 -0.442192625156042 0.783886533572187 0.00124110995600457 0.999243914683908 miRNAWalker2_validate;miRTarBase -0.242142580460552 8.04731548441957e-07 NA NA NA hsa-miR-130b-3p TGFBR1 -0.221667315324818 0.824660172394714 0.00124110995600457 0.999243914683908 miRNATAP -0.198665202115668 3.9093965386181e-07 NA NA NA hsa-miR-142-3p TGFBR1 -0.154235241441331 0.946098054588918 0.00124110995600457 0.999243914683908 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.181010377361328 4.07023073215286e-09 NA NA NA hsa-miR-142-5p TGFBR1 -0.118920788314118 0.929665277963083 0.00124110995600457 0.999243914683908 mirMAP -0.126563250596549 0.00026737180135806 NA NA NA hsa-miR-144-3p TGFBR1 0.0482420655617901 0.935871997593533 0.00124110995600457 0.999243914683908 miRNATAP -0.108595248763643 2.95829192305704e-06 NA NA NA hsa-miR-16-2-3p TGFBR1 -0.36717860153421 0.546850726070016 0.00124110995600457 0.999243914683908 mirMAP -0.211915448658369 7.46540476693612e-10 NA NA NA hsa-miR-186-5p TGFBR1 -0.318786974828757 0.85412722938961 0.00124110995600457 0.999243914683908 mirMAP -0.276125782651132 2.2449396007454e-07 NA NA NA hsa-miR-200b-3p TGFBR1 -0.426401948379212 0.863957108574195 0.00124110995600457 0.999243914683908 mirMAP -0.214646358388842 5.24492545239837e-09 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-27a-3p TGFBR1 -0.123902317731458 0.958804393510999 0.00124110995600457 0.999243914683908 miRNATAP -0.237990444416657 0.000112176104545918 NA NA NA hsa-miR-32-3p TGFBR1 -0.568003960723004 0.13133163420273 0.00124110995600457 0.999243914683908 mirMAP;miRNATAP -0.126315502555499 4.90766464474951e-06 NA NA NA hsa-miR-331-3p TGFBR1 -0.40204226129616 0.670588911553669 0.00124110995600457 0.999243914683908 PITA;miRNATAP -0.161899933877444 9.07636194244758e-05 NA NA NA hsa-miR-339-5p TGFBR1 -0.300425087100667 0.712912847076788 0.00124110995600457 0.999243914683908 miRanda -0.158492844692753 3.60831717487203e-07 NA NA NA hsa-miR-361-5p TGFBR1 -0.138735309928775 0.941495130308343 0.00124110995600457 0.999243914683908 miRanda;mirMAP;miRNATAP -0.180917830099494 0.0059258202039871 NA NA NA hsa-miR-374a-5p TGFBR1 -0.343007247142618 0.766921280269271 0.00124110995600457 0.999243914683908 mirMAP -0.178866450890983 0.00123101989663523 NA NA NA hsa-miR-374b-5p TGFBR1 -0.285682091626878 0.83569830479965 0.00124110995600457 0.999243914683908 mirMAP -0.186170536356415 0.000509150778807575 NA NA NA hsa-miR-429 TGFBR1 -0.456485631615963 0.806240953400535 0.00124110995600457 0.999243914683908 miRanda;miRNATAP -0.176295181680884 3.07555249157355e-09 NA NA NA hsa-miR-452-3p TGFBR1 -0.167134177977311 0.799008246175244 0.00124110995600457 0.999243914683908 mirMAP -0.13885089690337 2.55463265141557e-07 NA NA NA hsa-miR-454-3p TGFBR1 -0.101514866328011 0.843545158256191 0.00124110995600457 0.999243914683908 mirMAP;miRNATAP -0.182369219248642 7.20948009603019e-05 NA NA NA hsa-miR-500a-5p TGFBR1 -0.71978560736831 0.188073776225276 0.00124110995600457 0.999243914683908 mirMAP -0.111291119218986 0.000753124039757659 NA NA NA hsa-miR-576-5p TGFBR1 -0.506413219377403 0.417187951364173 0.00124110995600457 0.999243914683908 mirMAP -0.200594790014237 1.2932560172484e-07 NA NA NA hsa-miR-577 TGFBR1 -1.06238199218774 0.326056761787754 0.00124110995600457 0.999243914683908 PITA;miRNATAP -0.126907073878987 5.93530270860224e-11 NA NA NA hsa-miR-589-3p TGFBR1 -0.835836305204965 0.0112001563801511 0.00124110995600457 0.999243914683908 mirMAP -0.130862459779338 1.10108854111338e-05 NA NA NA hsa-miR-590-3p TGFBR1 -0.279244755376859 0.59126669933662 0.00124110995600457 0.999243914683908 PITA;miRanda;mirMAP;miRNATAP -0.197629616791323 2.47236635685616e-10 NA NA NA hsa-miR-590-5p TGFBR1 -0.547819833829572 0.472735645776647 0.00124110995600457 0.999243914683908 PITA;miRanda -0.208533080413366 2.72277854774884e-10 NA NA NA hsa-miR-7-1-3p TGFBR1 -0.462485777435991 0.665899751398166 0.00124110995600457 0.999243914683908 mirMAP -0.203049700959859 4.06299239838107e-08 NA NA NA hsa-miR-769-5p TGFBR1 -0.306614906942583 0.735704301598833 0.00124110995600457 0.999243914683908 PITA;miRNATAP -0.231566188241663 4.08025501967397e-06 NA NA NA hsa-miR-98-5p TGFBR1 -0.168162186023221 0.898802461503524 0.00124110995600457 0.999243914683908 miRNAWalker2_validate -0.1612568186822 0.00213841333130898 NA NA NA hsa-miR-106a-5p TGFBR2 -0.203919267842652 0.802213958426804 0.269587237099939 0.870007828511391 miRTarBase;miRNATAP -0.212247099066353 2.3746834029512e-05 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 -0.297128724729339 0.869294443540749 0.269587237099939 0.870007828511391 miRNATAP -0.278499409131211 1.4512804732718e-06 NA NA NA hsa-miR-107 TGFBR2 -0.0365118169251648 0.988364120226869 0.269587237099939 0.870007828511391 miRanda;miRNATAP -0.258657827833485 0.00268496176996244 NA NA NA hsa-miR-130b-3p TGFBR2 -0.221667315324818 0.824660172394714 0.269587237099939 0.870007828511391 miRNAWalker2_validate;miRNATAP -0.234948289013456 6.25435105860835e-06 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-142-3p TGFBR2 -0.154235241441331 0.946098054588918 0.269587237099939 0.870007828511391 miRanda -0.171572571369406 3.4605144572624e-05 NA NA NA hsa-miR-142-5p TGFBR2 -0.118920788314118 0.929665277963083 0.269587237099939 0.870007828511391 PITA;miRNATAP -0.150829730969939 0.00103441288196037 NA NA NA hsa-miR-17-5p TGFBR2 -0.175448849583061 0.934544015912731 0.269587237099939 0.870007828511391 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.202674873010253 4.41872340360193e-06 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-186-5p TGFBR2 -0.318786974828757 0.85412722938961 0.269587237099939 0.870007828511391 miRNATAP -0.298142671640094 2.77766444472225e-05 NA NA NA hsa-miR-18a-5p TGFBR2 -0.498318455303917 0.61264091975585 0.269587237099939 0.870007828511391 miRNAWalker2_validate -0.21157771255869 6.19530165808006e-09 NA NA NA hsa-miR-19a-3p TGFBR2 -0.206793507801887 0.844637784802316 0.269587237099939 0.870007828511391 miRNAWalker2_validate;miRNATAP -0.214080254623996 2.89167307062839e-07 NA NA NA hsa-miR-19b-3p TGFBR2 -0.0268530183621474 0.986656783046572 0.269587237099939 0.870007828511391 miRNAWalker2_validate;miRNATAP -0.169689973607121 0.00083124966865725 NA NA NA hsa-miR-20a-5p TGFBR2 -0.179153323927949 0.928118119139752 0.269587237099939 0.870007828511391 miRNAWalker2_validate;miRTarBase;miRNATAP -0.191382393773231 1.12810067949716e-05 NA NA NA hsa-miR-21-5p TGFBR2 -0.148920887107433 0.970240620972126 0.269587237099939 0.870007828511391 miRNAWalker2_validate;miRTarBase;miRNATAP -0.378408250708094 9.64982886506476e-06 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-33a-3p TGFBR2 -0.794543849238581 0.0105203072007922 0.269587237099939 0.870007828511391 mirMAP -0.17772624552639 3.43365837652915e-05 NA NA NA hsa-miR-429 TGFBR2 -0.456485631615963 0.806240953400535 0.269587237099939 0.870007828511391 miRNATAP -0.169552970655109 2.27770942168393e-05 NA NA NA hsa-miR-590-3p TGFBR2 -0.279244755376859 0.59126669933662 0.269587237099939 0.870007828511391 miRanda -0.191969139563066 5.18384050707001e-06 NA NA NA hsa-miR-590-5p TGFBR2 -0.547819833829572 0.472735645776647 0.269587237099939 0.870007828511391 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.216537984110313 1.07280754650564e-06 NA NA NA hsa-miR-93-5p TGFBR2 -0.611073677204699 0.825297877093193 0.269587237099939 0.870007828511391 miRNAWalker2_validate;miRNATAP -0.250326372434556 4.86566614404577e-06 NA NA NA hsa-miR-339-5p TNF -0.300425087100667 0.712912847076788 -0.242556492684374 0.505877742425651 miRanda -0.240752524581911 0.00150463927692232 NA NA NA hsa-miR-429 TNF -0.456485631615963 0.806240953400535 -0.242556492684374 0.505877742425651 miRNATAP -0.201076512972768 0.00615440839426584 NA NA NA hsa-miR-577 TNF -1.06238199218774 0.326056761787754 -0.242556492684374 0.505877742425651 miRNATAP -0.134551715326189 0.00528975118205988 NA NA NA hsa-miR-126-5p TRAF6 0.0815213541035824 0.956637332055185 0.0605967707763138 0.93566050863473 MirTarget;mirMAP -0.105220676710989 0.00166688886790763 NA NA NA hsa-miR-374b-5p TRAF6 -0.285682091626878 0.83569830479965 0.0605967707763138 0.93566050863473 mirMAP -0.112210222247732 0.0018835378177398 NA NA NA