miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106b-5p APC 1.04856358809711 0.139094273282727 -0.543855103612224 0.253015890893651 miRNAWalker2_validate;miRTarBase -0.313795610281918 3.20314695735614e-32 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells liver cancer hsa-miR-107 APC 0.351433472692356 0.523819413335979 -0.543855103612224 0.253015890893651 miRanda -0.266050961631061 1.99405735689927e-14 NA NA NA hsa-miR-155-5p APC 1.12529442422533 0.131933535981501 -0.543855103612224 0.253015890893651 miRNAWalker2_validate;miRTarBase;miRNATAP -0.154771290746743 4.27853241366662e-14 23796566 Upregulated miR 155 in papillary thyroid carcinoma promotes tumor growth by targeting APC and activating Wnt/β catenin signaling; We have searched for miR-155 targets and identified the hypothesis that miR-155 could promote tumor growth of PTC by targeted regulation of adenomatous polyposis coli APC expression and activating the Wnt/β-catenin signaling; Further studies revealed that APC is a novel miR-155 target because miR-155 bound directly to its 3'-untranslated region and reduced both the mRNA and protein levels of APC; Similar to the miR-155 over-expression APC downregulation promoted cell growth whereas rescued APC expression reversed the promotive effect of miR-155; By targeting APC miR-155 efficiently regulates the Wnt/β-catenin signaling thyroid cancer hsa-miR-21-5p APC -0.142759573450327 0.928848736959803 -0.543855103612224 0.253015890893651 miRNAWalker2_validate -0.246283784759972 7.23712061544539e-21 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-27a-3p APC 0.628895559781173 0.490244908291708 -0.543855103612224 0.253015890893651 miRNAWalker2_validate;miRTarBase;miRNATAP -0.178295160206353 5.95535983433013e-08 22018270 Finally the APC gene was identified as the direct and functional target of miR-27 gastric cancer hsa-miR-374a-5p APC 0.47302975636239 0.309552532909276 -0.543855103612224 0.253015890893651 mirMAP -0.183579142691311 5.11997182923449e-07 NA NA NA hsa-miR-590-3p APC 1.01238246880436 6.25794947126089e-07 -0.543855103612224 0.253015890893651 PITA;miRanda;mirMAP;miRNATAP -0.118033171177274 5.72074719287459e-07 NA NA NA hsa-miR-125a-5p APC2 -0.142178978822393 0.87178508980574 -0.535624221401427 0.0139255364728863 mirMAP -0.15416857175893 0.00430379284665603 NA NA NA hsa-miR-125b-5p APC2 0.0924748507064983 0.917738193990351 -0.535624221401427 0.0139255364728863 mirMAP -0.2419595151452 1.3692162649798e-09 NA NA NA hsa-miR-20a-3p APC2 1.59525587761975 8.24972949847183e-10 -0.535624221401427 0.0139255364728863 mirMAP -0.138852827654145 1.45583029063542e-05 NA NA NA hsa-miR-2355-5p APC2 0.516125245105019 0.301078573145612 -0.535624221401427 0.0139255364728863 mirMAP -0.186684220875449 0.000506491734344051 NA NA NA hsa-miR-28-5p APC2 0.698472090600538 0.237744307568605 -0.535624221401427 0.0139255364728863 mirMAP -0.274501081998138 0.000152045555835454 NA NA NA hsa-miR-345-5p APC2 1.09334749768931 0.00132772206314938 -0.535624221401427 0.0139255364728863 mirMAP -0.110916549318979 0.000360181957971393 NA NA NA hsa-miR-505-5p APC2 1.75027710858475 3.93634473894517e-10 -0.535624221401427 0.0139255364728863 mirMAP -0.173610865295371 1.44750832015884e-06 NA NA NA hsa-miR-126-5p AXIN1 -0.00481947073974087 0.994552231964025 0.209813869998221 0.687740901391552 miRNATAP -0.232873177453548 6.89302611938727e-24 NA NA NA hsa-miR-335-5p AXIN1 0.0404259244994374 0.914858946651589 0.209813869998221 0.687740901391552 miRNAWalker2_validate -0.142684376401892 7.8023220735108e-23 NA NA NA hsa-miR-539-5p AXIN1 -0.0457056973351353 0.867113005919876 0.209813869998221 0.687740901391552 miRNATAP -0.162890931040002 4.17509848174996e-25 NA NA NA hsa-let-7a-3p AXIN2 0.311896921808493 0.499509698073189 -1.12620971420341 0.00118293795582942 miRNATAP -0.155309998742421 0.00126021107839157 NA NA NA hsa-let-7g-3p AXIN2 0.856197325425713 0.0358560037531409 -1.12620971420341 0.00118293795582942 MirTarget -0.15927262941163 2.22164738358529e-09 NA NA NA hsa-miR-103a-3p AXIN2 -0.0705890709254717 0.957272313720577 -1.12620971420341 0.00118293795582942 miRNAWalker2_validate;MirTarget;miRNATAP -0.200585660302729 7.71528936514313e-05 NA NA NA hsa-miR-107 AXIN2 0.351433472692356 0.523819413335979 -1.12620971420341 0.00118293795582942 miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.313818454372385 2.10386522757559e-09 26191213 miR 107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2; At the molecular level our results suggested that expression of Axin2 was negatively regulated by miR-107; Our observations suggested that miR-107 could promote HCC cells proliferation via targeting Axin2 and might represent a potential therapeutic target for HCC liver cancer hsa-miR-15a-5p AXIN2 0.342480184869245 0.605040217513538 -1.12620971420341 0.00118293795582942 MirTarget;miRNATAP -0.308482083886854 2.3359131858061e-10 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-15b-5p AXIN2 0.687228605707872 0.304427884697749 -1.12620971420341 0.00118293795582942 miRTarBase;MirTarget;miRNATAP -0.249089153159517 2.51640038854339e-11 NA NA NA hsa-miR-16-2-3p AXIN2 1.04875803256727 0.000133454779801128 -1.12620971420341 0.00118293795582942 mirMAP -0.242354247916614 1.68855735572963e-12 NA NA NA hsa-miR-16-5p AXIN2 0.608716035131087 0.441059798918702 -1.12620971420341 0.00118293795582942 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.250388265601038 2.07986806159543e-08 NA NA NA hsa-miR-221-3p AXIN2 0.889236679257595 0.165212011318271 -1.12620971420341 0.00118293795582942 miRNATAP -0.187234880985831 2.24061800824779e-07 NA NA NA hsa-miR-222-3p AXIN2 1.01165425875596 0.0347025183740878 -1.12620971420341 0.00118293795582942 miRNATAP -0.187336402293767 2.41688030584989e-08 NA NA NA hsa-miR-29a-5p AXIN2 0.800121562512528 0.00103825219976412 -1.12620971420341 0.00118293795582942 MirTarget -0.206530050833047 3.89834897393732e-08 NA NA NA hsa-miR-429 AXIN2 0.448029985835258 0.437184735816941 -1.12620971420341 0.00118293795582942 miRanda -0.190517672757253 2.55529446378965e-15 NA NA NA hsa-miR-582-5p AXIN2 0.84770952065171 0.000866226913967834 -1.12620971420341 0.00118293795582942 miRNATAP -0.23410335462888 1.51202842984391e-13 NA NA NA hsa-miR-590-3p AXIN2 1.01238246880436 6.25794947126089e-07 -1.12620971420341 0.00118293795582942 MirTarget;PITA;miRanda;miRNATAP -0.363534362507334 4.95187752463635e-26 NA NA NA hsa-miR-107 BTRC 0.351433472692356 0.523819413335979 -0.934469346915098 0.0578416424166955 MirTarget;miRanda;miRNATAP -0.176399193835294 3.95816507165993e-07 NA NA NA hsa-miR-130a-3p BTRC 0.849038376258018 0.133664106340641 -0.934469346915098 0.0578416424166955 mirMAP -0.123950670209092 1.81836770188752e-08 NA NA NA hsa-miR-130b-3p BTRC 1.16970507422762 6.85086072809354e-05 -0.934469346915098 0.0578416424166955 mirMAP -0.166208529900913 2.6200359050573e-14 NA NA NA hsa-miR-132-3p BTRC 0.240816226207972 0.678532290124258 -0.934469346915098 0.0578416424166955 MirTarget -0.16624989082982 1.42128564671786e-06 NA NA NA hsa-miR-15a-5p BTRC 0.342480184869245 0.605040217513538 -0.934469346915098 0.0578416424166955 miRNAWalker2_validate;MirTarget;miRNATAP -0.190986059010062 3.25059412787152e-09 NA NA NA hsa-miR-185-5p BTRC 0.413180953895098 0.435464963453554 -0.934469346915098 0.0578416424166955 mirMAP -0.27817268481314 2.83790268646345e-15 NA NA NA hsa-miR-186-5p BTRC 1.04333228080691 0.148711371364268 -0.934469346915098 0.0578416424166955 mirMAP -0.153390623021547 3.48923481425663e-07 NA NA NA hsa-miR-212-3p BTRC 0.733470062196833 0.0007562475324171 -0.934469346915098 0.0578416424166955 MirTarget -0.173369799058415 8.47662747538148e-14 NA NA NA hsa-miR-22-5p BTRC 0.386811466292275 0.351646252133174 -0.934469346915098 0.0578416424166955 miRNATAP -0.169967299467369 1.97069244765403e-11 NA NA NA hsa-miR-224-5p BTRC 2.65799597897592 2.73629620293273e-08 -0.934469346915098 0.0578416424166955 MirTarget -0.132498017840424 7.27857382043359e-34 NA NA NA hsa-miR-28-5p BTRC 0.698472090600538 0.237744307568605 -0.934469346915098 0.0578416424166955 miRanda -0.245382923565365 1.23962341723426e-09 NA NA NA hsa-miR-361-3p BTRC 0.35229279501788 0.603486581638137 -0.934469346915098 0.0578416424166955 MirTarget;PITA;miRNATAP -0.232101959717311 2.15887515093051e-09 NA NA NA hsa-miR-505-3p BTRC 1.82926040846064 3.48624069415488e-05 -0.934469346915098 0.0578416424166955 MirTarget -0.19714346161221 2.15462077391573e-20 NA NA NA hsa-miR-576-5p BTRC 1.29396616748627 4.70941163094532e-05 -0.934469346915098 0.0578416424166955 mirMAP -0.106901631789694 1.17834154523049e-05 NA NA NA hsa-miR-92a-3p BTRC 1.22719477478376 0.303128344063904 -0.934469346915098 0.0578416424166955 miRNAWalker2_validate -0.218742875572353 1.77336318401607e-14 NA NA NA hsa-miR-195-3p CACYBP -0.148955193954253 0.573960981017585 0.354654734255933 0.541551554553123 mirMAP -0.232768845045075 1.84734186920475e-28 NA NA NA hsa-miR-30a-3p CACYBP -0.300076833471234 0.808455573798624 0.354654734255933 0.541551554553123 MirTarget -0.119257746654091 3.45819271489493e-13 NA NA NA hsa-miR-30e-3p CACYBP 0.529604563002 0.641658069028144 0.354654734255933 0.541551554553123 MirTarget -0.156128522151445 7.85773396828642e-06 NA NA NA hsa-miR-125a-5p CAMK2A -0.142178978822393 0.87178508980574 -0.121211311432653 0.634125054925633 mirMAP -0.306152492531801 6.24694931450318e-07 NA NA NA hsa-miR-19b-1-5p CAMK2A 1.36505959967354 5.07450090840118e-07 -0.121211311432653 0.634125054925633 mirMAP -0.127806056998247 0.00655388531126769 NA NA NA hsa-miR-25-3p CAMK2A 0.734786337660527 0.544331320304672 -0.121211311432653 0.634125054925633 MirTarget -0.21042761959986 0.00657433659879039 NA NA NA hsa-miR-26a-5p CAMK2A -0.0526989605494563 0.958167127738582 -0.121211311432653 0.634125054925633 miRNATAP -0.226702776972991 0.00412036831502982 NA NA NA hsa-miR-26b-5p CAMK2A -0.0240822851785545 0.977302874814694 -0.121211311432653 0.634125054925633 miRNATAP -0.201669642863581 0.00121808822640433 NA NA NA hsa-miR-30a-5p CAMK2A -0.48552268915326 0.730142516403566 -0.121211311432653 0.634125054925633 mirMAP -0.208560410066033 1.02470554341187e-07 NA NA NA hsa-miR-30b-5p CAMK2A 0.1279779286756 0.872682355905147 -0.121211311432653 0.634125054925633 mirMAP -0.299993290244448 2.31458535837861e-08 NA NA NA hsa-miR-30c-5p CAMK2A 0.2904764284977 0.738803502565399 -0.121211311432653 0.634125054925633 mirMAP -0.343105483733946 8.04306460208188e-09 NA NA NA hsa-miR-30d-5p CAMK2A 0.171445446354708 0.882863964947721 -0.121211311432653 0.634125054925633 mirMAP -0.500830199163001 3.66036488570952e-13 NA NA NA hsa-miR-30e-5p CAMK2A 0.74013844669909 0.511970582859704 -0.121211311432653 0.634125054925633 mirMAP -0.34551062842794 1.86639620197896e-06 NA NA NA hsa-miR-335-5p CAMK2A 0.0404259244994374 0.914858946651589 -0.121211311432653 0.634125054925633 mirMAP -0.159866461109795 6.97412013828671e-07 NA NA NA hsa-miR-338-3p CAMK2A -0.299081553502284 0.690790317255839 -0.121211311432653 0.634125054925633 miRNATAP -0.209986268079133 4.80281615465648e-07 NA NA NA hsa-miR-361-3p CAMK2A 0.35229279501788 0.603486581638137 -0.121211311432653 0.634125054925633 mirMAP -0.326015515432829 4.08216101266611e-05 NA NA NA hsa-miR-625-5p CAMK2A -0.12821717169837 0.460013404839361 -0.121211311432653 0.634125054925633 mirMAP -0.179712426290662 7.7289889783295e-05 NA NA NA hsa-miR-7-1-3p CAMK2A -0.136535237676745 0.726879891153832 -0.121211311432653 0.634125054925633 MirTarget -0.262098249281639 8.03032900468887e-09 NA NA NA hsa-miR-92a-3p CAMK2A 1.22719477478376 0.303128344063904 -0.121211311432653 0.634125054925633 MirTarget -0.281889994119232 1.60654390365786e-06 NA NA NA hsa-miR-1271-5p CAMK2B 0.734083414954632 0.00016191462050357 -1.555594885724 1.35370226826514e-06 mirMAP -0.199793610717617 0.000348914268332107 NA NA NA hsa-miR-150-5p CAMK2B 1.16771122623924 0.175252906436503 -1.555594885724 1.35370226826514e-06 mirMAP -0.198156634053672 4.48723158474492e-06 NA NA NA hsa-miR-186-5p CAMK2B 1.04333228080691 0.148711371364268 -1.555594885724 1.35370226826514e-06 miRNAWalker2_validate;miRNATAP -0.420009924398004 3.08262880687716e-06 NA NA NA hsa-miR-18a-5p CAMK2B 2.29585803678176 4.13931899001596e-14 -1.555594885724 1.35370226826514e-06 mirMAP -0.272652665944852 5.85107409807785e-08 NA NA NA hsa-miR-2355-5p CAMK2B 0.516125245105019 0.301078573145612 -1.555594885724 1.35370226826514e-06 mirMAP -0.534987844428681 2.11741953815093e-09 NA NA NA hsa-miR-24-3p CAMK2B 0.834102408142648 0.36961872772158 -1.555594885724 1.35370226826514e-06 MirTarget -0.668590574540919 9.25330039258928e-14 NA NA NA hsa-miR-362-5p CAMK2B 0.820801646347614 0.0107637300891325 -1.555594885724 1.35370226826514e-06 miRNATAP -0.373141196834054 2.76360587755669e-09 NA NA NA hsa-miR-589-3p CAMK2B 0.869015836905941 1.30925035072401e-06 -1.555594885724 1.35370226826514e-06 MirTarget -0.282678683570449 6.81881545878125e-07 NA NA NA hsa-miR-590-3p CAMK2B 1.01238246880436 6.25794947126089e-07 -1.555594885724 1.35370226826514e-06 miRanda -0.261169954511755 0.000193900443755323 NA NA NA hsa-miR-628-5p CAMK2B 0.455006342781375 0.187028999557042 -1.555594885724 1.35370226826514e-06 miRNATAP -0.162840590843991 0.000430398534263797 NA NA NA hsa-miR-200b-3p CAMK2D 0.224286846990266 0.786394257540977 0.340092792861128 0.489825185396549 TargetScan;mirMAP -0.176484130686564 3.1915455415824e-14 NA NA NA hsa-miR-342-3p CAMK2D -0.720941204737844 0.328091715069398 0.340092792861128 0.489825185396549 miRanda -0.127822107335849 2.3223826328776e-06 NA NA NA hsa-miR-429 CAMK2D 0.448029985835258 0.437184735816941 0.340092792861128 0.489825185396549 mirMAP;miRNATAP -0.142005527474459 9.28571715889098e-12 NA NA NA hsa-let-7i-5p CCND1 0.491983487993952 0.539800598932235 -1.63598241592522 0.0353580902191039 miRNATAP -0.759700962013673 2.31065071397228e-16 NA NA NA hsa-miR-106a-5p CCND1 1.15783699791289 0.000894643692244881 -1.63598241592522 0.0353580902191039 MirTarget;miRNATAP -0.174359830876255 2.65007775906387e-06 NA NA NA hsa-miR-106b-5p CCND1 1.04856358809711 0.139094273282727 -1.63598241592522 0.0353580902191039 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.258644062815507 8.24041501542474e-07 NA NA NA hsa-miR-142-3p CCND1 1.18219258029821 0.19611934127025 -1.63598241592522 0.0353580902191039 miRanda -0.111966511365121 0.000240262100008297 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-142-5p CCND1 1.23477289272799 0.0150054709615798 -1.63598241592522 0.0353580902191039 PITA -0.210173449112337 1.63510921192815e-09 NA NA NA hsa-miR-150-5p CCND1 1.16771122623924 0.175252906436503 -1.63598241592522 0.0353580902191039 mirMAP -0.187252742453937 1.34917625164856e-11 NA NA NA hsa-miR-155-5p CCND1 1.12529442422533 0.131933535981501 -1.63598241592522 0.0353580902191039 miRNAWalker2_validate -0.298681895389198 2.32439253453393e-14 26955820 MicroRNA 155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastric cancer cell growth by targeting cyclin D1 staging gastric cancer hsa-miR-15b-5p CCND1 0.687228605707872 0.304427884697749 -1.63598241592522 0.0353580902191039 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.125463191460891 0.00921827566968511 NA NA NA hsa-miR-17-5p CCND1 1.80801649919324 0.017740816345401 -1.63598241592522 0.0353580902191039 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.23795787679729 6.72139201694027e-09 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-186-5p CCND1 1.04333228080691 0.148711371364268 -1.63598241592522 0.0353580902191039 mirMAP -0.494988902443749 5.18517439622754e-18 NA NA NA hsa-miR-19a-3p CCND1 1.46790979235261 0.000361171910570302 -1.63598241592522 0.0353580902191039 miRNAWalker2_validate;miRTarBase;miRNATAP -0.216023850578105 8.24189814452405e-09 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 1.36505959967354 5.07450090840118e-07 -1.63598241592522 0.0353580902191039 miRNAWalker2_validate;miRTarBase -0.206802040114629 3.03348057195458e-06 NA NA NA hsa-miR-19b-3p CCND1 1.16012277183793 0.0628519598637838 -1.63598241592522 0.0353580902191039 miRNATAP -0.249444343540709 5.93160032007176e-08 NA NA NA hsa-miR-20a-5p CCND1 1.44423592705205 0.0465200458169632 -1.63598241592522 0.0353580902191039 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.218045690926451 3.58399990050218e-07 NA NA NA hsa-miR-23b-3p CCND1 0.325018208255861 0.697275325712378 -1.63598241592522 0.0353580902191039 miRNATAP -0.2085521275068 0.000237936656088415 NA NA NA hsa-miR-29a-3p CCND1 0.46338784979134 0.683743087347155 -1.63598241592522 0.0353580902191039 mirMAP -0.358623457755512 1.12263469726765e-09 NA NA NA hsa-miR-340-5p CCND1 0.362079103949629 0.350652374274417 -1.63598241592522 0.0353580902191039 mirMAP -0.157803294541288 0.00210629660665075 NA NA NA hsa-miR-374a-5p CCND1 0.47302975636239 0.309552532909276 -1.63598241592522 0.0353580902191039 MirTarget -0.556352001430099 7.67413515717595e-16 27191497 microRNA 374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway; Furthermore luciferase reporter assays confirmed that miR-374a could directly reduce CCND1; We examined miR-374a levels by in situ hybridization and its correlation with CCND1 expression in CRC tumor tissues; High miR-374a expression with low level of CCND1 was protective factor in CRC; Together these findings indicate that miR-374a inactivates the PI3K/AKT axis by inhibiting CCND1 suppressing of colon cancer progression progression colon cancer hsa-miR-374b-5p CCND1 0.478896841162915 0.365769179152496 -1.63598241592522 0.0353580902191039 miRNAWalker2_validate;MirTarget -0.531193112029599 5.3445494840887e-15 NA NA NA hsa-miR-424-5p CCND1 0.584229437974506 0.326869614530055 -1.63598241592522 0.0353580902191039 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.165346668007668 1.17175782770906e-05 NA NA NA hsa-miR-495-3p CCND1 0.041567851465774 0.887070501543368 -1.63598241592522 0.0353580902191039 MirTarget -0.2655760978611 1.39010362325337e-11 NA NA NA hsa-miR-511-5p CCND1 1.26405448316917 7.0542025133613e-05 -1.63598241592522 0.0353580902191039 MirTarget -0.21938803198833 1.27831310404617e-13 NA NA NA hsa-miR-589-3p CCND1 0.869015836905941 1.30925035072401e-06 -1.63598241592522 0.0353580902191039 MirTarget -0.116809863299678 0.00155105242627909 NA NA NA hsa-miR-590-3p CCND1 1.01238246880436 6.25794947126089e-07 -1.63598241592522 0.0353580902191039 mirMAP -0.221641713536578 8.94498108920728e-07 NA NA NA hsa-miR-9-5p CCND1 2.31356623051719 0.0110746694972708 -1.63598241592522 0.0353580902191039 miRNAWalker2_validate -0.162121975003827 1.12937727530253e-12 NA NA NA hsa-miR-92a-3p CCND1 1.22719477478376 0.303128344063904 -1.63598241592522 0.0353580902191039 miRNAWalker2_validate -0.355039027931141 1.3665845638516e-10 NA NA NA hsa-miR-93-5p CCND1 0.943892623097563 0.3984984603332 -1.63598241592522 0.0353580902191039 miRNAWalker2_validate;MirTarget;miRNATAP -0.160469090487963 0.00197437840989499 NA NA NA hsa-miR-942-5p CCND1 1.66424405811907 1.20721372419515e-13 -1.63598241592522 0.0353580902191039 MirTarget -0.261175156275166 1.39422778172566e-10 NA NA NA hsa-let-7a-3p CCND2 0.311896921808493 0.499509698073189 -0.0682487762990531 0.88928033898544 mirMAP -0.215275364862757 3.63993039775257e-07 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7e-5p CCND2 -0.0783704502022449 0.932705916978429 -0.0682487762990531 0.88928033898544 miRNATAP -0.168033346737038 0.000309648297817392 NA NA NA hsa-miR-106a-5p CCND2 1.15783699791289 0.000894643692244881 -0.0682487762990531 0.88928033898544 miRNATAP -0.117204496646304 5.04333413242193e-06 NA NA NA hsa-miR-106b-5p CCND2 1.04856358809711 0.139094273282727 -0.0682487762990531 0.88928033898544 miRNAWalker2_validate;miRTarBase;miRNATAP -0.324304654054346 9.75129599972944e-20 NA NA NA hsa-miR-130b-5p CCND2 1.3947936173305 4.50465898911354e-07 -0.0682487762990531 0.88928033898544 mirMAP -0.113060251982174 8.9777676148938e-06 NA NA NA hsa-miR-141-3p CCND2 0.518554136840043 0.543645265590794 -0.0682487762990531 0.88928033898544 MirTarget;TargetScan -0.300723945575078 8.35441899721039e-47 NA NA NA hsa-miR-151a-3p CCND2 0.488743658702951 0.622267340258825 -0.0682487762990531 0.88928033898544 mirMAP -0.17767569994557 0.000108302525662849 NA NA NA hsa-miR-15a-5p CCND2 0.342480184869245 0.605040217513538 -0.0682487762990531 0.88928033898544 miRNAWalker2_validate;miRTarBase;miRNATAP -0.382989347535057 1.85935181542133e-19 NA NA NA hsa-miR-15b-5p CCND2 0.687228605707872 0.304427884697749 -0.0682487762990531 0.88928033898544 miRNATAP -0.200863767053961 1.18885859507843e-09 NA NA NA hsa-miR-16-5p CCND2 0.608716035131087 0.441059798918702 -0.0682487762990531 0.88928033898544 miRNAWalker2_validate;miRNATAP -0.126011969570663 0.00149555991801246 NA NA NA hsa-miR-17-5p CCND2 1.80801649919324 0.017740816345401 -0.0682487762990531 0.88928033898544 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.218141508896336 9.56625930755479e-15 NA NA NA hsa-miR-182-5p CCND2 -0.350218686073308 0.794131834526037 -0.0682487762990531 0.88928033898544 miRNAWalker2_validate;miRTarBase;miRNATAP -0.333755066801542 7.98233999507297e-38 NA NA NA hsa-miR-183-5p CCND2 0.204550384370393 0.863354421890003 -0.0682487762990531 0.88928033898544 miRNATAP -0.301857921065621 1.16754966176673e-39 NA NA NA hsa-miR-185-5p CCND2 0.413180953895098 0.435464963453554 -0.0682487762990531 0.88928033898544 MirTarget;miRNATAP -0.252091965164496 1.07493887045353e-07 NA NA NA hsa-miR-191-5p CCND2 -0.182892690036443 0.828751539897811 -0.0682487762990531 0.88928033898544 MirTarget -0.190841372088135 4.05600831845751e-09 NA NA NA hsa-miR-19a-3p CCND2 1.46790979235261 0.000361171910570302 -0.0682487762990531 0.88928033898544 MirTarget;miRNATAP -0.185131062383478 6.94387115240903e-13 NA NA NA hsa-miR-19b-3p CCND2 1.16012277183793 0.0628519598637838 -0.0682487762990531 0.88928033898544 miRNAWalker2_validate;MirTarget;miRNATAP -0.166767747836903 1.62862778749919e-07 NA NA NA hsa-miR-200a-3p CCND2 0.298946102269216 0.671358593831 -0.0682487762990531 0.88928033898544 MirTarget -0.261226562912324 4.31939405604759e-36 NA NA NA hsa-miR-20a-5p CCND2 1.44423592705205 0.0465200458169632 -0.0682487762990531 0.88928033898544 miRNAWalker2_validate;miRTarBase;miRNATAP -0.235095611327971 1.01223581717651e-15 NA NA NA hsa-miR-20b-5p CCND2 0.530665078264877 0.214523921293588 -0.0682487762990531 0.88928033898544 miRNATAP -0.104708964184932 6.77204420924901e-08 NA NA NA hsa-miR-21-3p CCND2 0.115900341574742 0.904443786801208 -0.0682487762990531 0.88928033898544 mirMAP -0.127404398971718 2.08059143790106e-05 NA NA NA hsa-miR-29b-3p CCND2 0.271083597599281 0.740286663164405 -0.0682487762990531 0.88928033898544 MirTarget;miRNATAP -0.166630108966211 2.5453033344596e-06 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-301a-3p CCND2 0.968506401137921 0.000570564850124159 -0.0682487762990531 0.88928033898544 miRNAWalker2_validate -0.182363632693643 1.4299291622836e-15 NA NA NA hsa-miR-3065-3p CCND2 -0.215298286615624 0.657132844838708 -0.0682487762990531 0.88928033898544 MirTarget;miRNATAP -0.215305118861858 1.68654607913855e-26 NA NA NA hsa-miR-30d-3p CCND2 0.267731984838241 0.27012774089276 -0.0682487762990531 0.88928033898544 mirMAP -0.277305057640272 1.40644960106378e-12 NA NA NA hsa-miR-320b CCND2 0.712468682578545 0.00260489977004221 -0.0682487762990531 0.88928033898544 mirMAP;miRNATAP -0.105338094438455 0.000662995774848357 NA NA NA hsa-miR-324-3p CCND2 0.751526916869153 0.0436798222769339 -0.0682487762990531 0.88928033898544 miRNAWalker2_validate -0.187482582074807 4.91214943402943e-08 NA NA NA hsa-miR-331-5p CCND2 0.399733586480102 0.0121010815563507 -0.0682487762990531 0.88928033898544 miRNATAP -0.224823939820064 1.69348201302645e-09 NA NA NA hsa-miR-342-3p CCND2 -0.720941204737844 0.328091715069398 -0.0682487762990531 0.88928033898544 miRNAWalker2_validate;mirMAP -0.103848624831325 0.000189231379572542 NA NA NA hsa-miR-429 CCND2 0.448029985835258 0.437184735816941 -0.0682487762990531 0.88928033898544 miRNATAP -0.232180070081619 1.04111918722712e-28 NA NA NA hsa-miR-590-3p CCND2 1.01238246880436 6.25794947126089e-07 -0.0682487762990531 0.88928033898544 miRanda;mirMAP -0.13833737728579 9.4871454586344e-06 NA NA NA hsa-miR-590-5p CCND2 1.40236682288609 3.89322108176281e-06 -0.0682487762990531 0.88928033898544 mirMAP -0.151134124586935 3.93710909950627e-07 NA NA NA hsa-miR-660-5p CCND2 0.789334042528136 0.108629249007974 -0.0682487762990531 0.88928033898544 mirMAP -0.106401121539045 0.00339848496849202 NA NA NA hsa-miR-7-1-3p CCND2 -0.136535237676745 0.726879891153832 -0.0682487762990531 0.88928033898544 mirMAP -0.138929082076826 3.22847149980611e-06 NA NA NA hsa-miR-93-5p CCND2 0.943892623097563 0.3984984603332 -0.0682487762990531 0.88928033898544 miRNATAP -0.400435186075896 5.37578279205249e-31 NA NA NA hsa-miR-96-5p CCND2 0.100415780625178 0.816616062681011 -0.0682487762990531 0.88928033898544 TargetScan;miRNATAP -0.311897703713413 7.58506265459077e-49 NA NA NA hsa-miR-221-3p CHD8 0.889236679257595 0.165212011318271 -0.306964408400919 0.608515830429692 MirTarget;miRNATAP -0.147913788096852 9.94945179288004e-25 NA NA NA hsa-miR-361-5p CREBBP 0.295581181703002 0.679805903809273 -0.247277084895578 0.699942513009845 PITA;miRanda;miRNATAP -0.169327426710038 1.27069129226647e-06 NA NA NA hsa-miR-374a-3p CREBBP 0.47806575213705 0.580820043553098 -0.247277084895578 0.699942513009845 miRNATAP -0.118175129899399 3.92114134022804e-06 NA NA NA hsa-miR-590-3p CREBBP 1.01238246880436 6.25794947126089e-07 -0.247277084895578 0.699942513009845 PITA;miRanda;mirMAP;miRNATAP -0.100564166407458 8.68617817381304e-10 NA NA NA hsa-miR-107 CSNK1A1 0.351433472692356 0.523819413335979 -0.622112279875369 0.41081891564416 PITA;miRanda;miRNATAP -0.122179164718018 1.10059616048406e-07 NA NA NA hsa-miR-155-5p CSNK1A1 1.12529442422533 0.131933535981501 -0.622112279875369 0.41081891564416 miRNAWalker2_validate;miRTarBase;miRNATAP -0.112093319289922 5.71697685710134e-17 NA NA NA hsa-miR-17-5p CSNK1A1 1.80801649919324 0.017740816345401 -0.622112279875369 0.41081891564416 TargetScan -0.139354338789202 6.20716702675882e-24 NA NA NA hsa-miR-186-5p CSNK1A1 1.04333228080691 0.148711371364268 -0.622112279875369 0.41081891564416 miRNAWalker2_validate;miRNATAP -0.111953585604854 1.83989613326677e-08 NA NA NA hsa-miR-19a-3p CSNK1A1 1.46790979235261 0.000361171910570302 -0.622112279875369 0.41081891564416 mirMAP -0.108764735747862 1.2137097303677e-17 NA NA NA hsa-miR-19b-3p CSNK1A1 1.16012277183793 0.0628519598637838 -0.622112279875369 0.41081891564416 mirMAP -0.113820613941943 4.04480731084776e-13 NA NA NA hsa-miR-30e-5p CSNK1A1 0.74013844669909 0.511970582859704 -0.622112279875369 0.41081891564416 MirTarget -0.118629602890873 4.59975508016632e-07 NA NA NA hsa-miR-501-3p CSNK1A1 0.941458626153224 0.0447629051861443 -0.622112279875369 0.41081891564416 TargetScan;miRNATAP -0.102750322971741 1.05636462078204e-10 NA NA NA hsa-miR-502-3p CSNK1A1 0.895808459930024 0.000779849795359335 -0.622112279875369 0.41081891564416 miRNATAP -0.176013262432281 1.80237661044146e-22 NA NA NA hsa-miR-576-5p CSNK1A1 1.29396616748627 4.70941163094532e-05 -0.622112279875369 0.41081891564416 mirMAP -0.103328281253168 1.20036851836147e-10 NA NA NA hsa-miR-652-3p CSNK1A1 0.509058920211892 0.251555424968498 -0.622112279875369 0.41081891564416 miRNAWalker2_validate -0.106904286901307 7.62564332600731e-11 NA NA NA hsa-let-7a-5p CSNK2A1 -0.246449658252354 0.857810222667201 -0.0139449153487412 0.979727240720655 miRNAWalker2_validate;TargetScan -0.135347217436861 5.73489571379612e-07 NA NA NA hsa-let-7c-5p CSNK2A1 0.0669173618813819 0.949215781382076 -0.0139449153487412 0.979727240720655 miRNAWalker2_validate -0.112963831397893 1.45380762126855e-14 NA NA NA hsa-miR-143-3p CSNK2A1 0.0224632583428974 0.987470406835805 -0.0139449153487412 0.979727240720655 MirTarget -0.102863413291093 1.39184437094928e-08 NA NA NA hsa-miR-26a-5p CSNK2A1 -0.0526989605494563 0.958167127738582 -0.0139449153487412 0.979727240720655 mirMAP -0.183032285298427 3.80367876396133e-11 NA NA NA hsa-miR-10b-5p CTBP1 -0.802647383158369 0.589117522662311 0.0902082929981063 0.888884365169083 miRNAWalker2_validate -0.131124284874422 2.1818976824128e-17 NA NA NA hsa-miR-1271-5p CTBP1 0.734083414954632 0.00016191462050357 0.0902082929981063 0.888884365169083 mirMAP -0.118815949476465 5.57969791453083e-21 NA NA NA hsa-miR-409-3p CTBP1 -0.194297569191983 0.630520748307576 0.0902082929981063 0.888884365169083 miRNATAP -0.123267122301907 3.51783238534121e-13 NA NA NA hsa-miR-589-5p CTNNB1 0.230201267274126 0.668365586561059 0.185538271009328 0.817565369459526 miRNATAP -0.163417588837067 5.37234569206233e-10 NA NA NA hsa-miR-125a-5p CTNNBIP1 -0.142178978822393 0.87178508980574 0.462382813708016 0.37623938783919 mirMAP -0.106861426150118 3.21438994353657e-05 NA NA NA hsa-miR-130a-3p CXXC4 0.849038376258018 0.133664106340641 -1.30769268523275 5.95588414495972e-07 miRNATAP -0.241623697494787 2.61410952091639e-06 NA NA NA hsa-miR-130b-3p CXXC4 1.16970507422762 6.85086072809354e-05 -1.30769268523275 5.95588414495972e-07 miRNATAP -0.23463521783126 4.93673028390429e-06 NA NA NA hsa-miR-146a-5p CXXC4 1.50457049554322 0.0123735084940492 -1.30769268523275 5.95588414495972e-07 MirTarget -0.177215728802693 0.000129668828770531 NA NA NA hsa-miR-146b-5p CXXC4 0.876334790841257 0.284935762703604 -1.30769268523275 5.95588414495972e-07 MirTarget;miRNATAP -0.402161602310286 2.78295064213365e-12 NA NA NA hsa-miR-186-5p CXXC4 1.04333228080691 0.148711371364268 -1.30769268523275 5.95588414495972e-07 mirMAP -0.185188272588669 0.00861357423571367 NA NA NA hsa-miR-19b-1-5p CXXC4 1.36505959967354 5.07450090840118e-07 -1.30769268523275 5.95588414495972e-07 MirTarget -0.218495308109611 4.52597594786824e-05 NA NA NA hsa-miR-21-5p CXXC4 -0.142759573450327 0.928848736959803 -1.30769268523275 5.95588414495972e-07 mirMAP -0.257452952558405 3.19200115682289e-05 NA NA NA hsa-miR-223-3p CXXC4 1.16361977127231 0.0727246245264288 -1.30769268523275 5.95588414495972e-07 MirTarget -0.339412266927715 5.92753918193085e-13 NA NA NA hsa-miR-224-5p CXXC4 2.65799597897592 2.73629620293273e-08 -1.30769268523275 5.95588414495972e-07 MirTarget -0.181942353850854 3.60612131804488e-12 NA NA NA hsa-miR-452-5p CXXC4 2.0200941872388 0.000263136484394316 -1.30769268523275 5.95588414495972e-07 miRNATAP -0.234320108333777 8.18417899337699e-14 NA NA NA hsa-miR-532-5p CXXC4 0.837154623550648 0.324129802476266 -1.30769268523275 5.95588414495972e-07 MirTarget;PITA;miRNATAP -0.496712025500665 4.77750045893798e-12 NA NA NA hsa-miR-589-5p CXXC4 0.230201267274126 0.668365586561059 -1.30769268523275 5.95588414495972e-07 MirTarget;miRNATAP -0.397030086932275 6.52239923121845e-07 NA NA NA hsa-miR-590-3p CXXC4 1.01238246880436 6.25794947126089e-07 -1.30769268523275 5.95588414495972e-07 mirMAP -0.22340700282172 4.26165162563516e-05 NA NA NA hsa-miR-590-5p CXXC4 1.40236682288609 3.89322108176281e-06 -1.30769268523275 5.95588414495972e-07 mirMAP -0.220064131956899 2.44213519940944e-05 NA NA NA hsa-miR-660-5p CXXC4 0.789334042528136 0.108629249007974 -1.30769268523275 5.95588414495972e-07 miRNATAP -0.558306258370776 2.42822704122193e-19 NA NA NA hsa-miR-708-3p CXXC4 -0.0956707206761838 0.867059431608446 -1.30769268523275 5.95588414495972e-07 MirTarget -0.255893073883026 2.2233000962564e-05 NA NA NA hsa-miR-889-3p CXXC4 -0.17134710821136 0.641837663634902 -1.30769268523275 5.95588414495972e-07 MirTarget -0.216720712252581 1.93828204405402e-05 NA NA NA hsa-miR-130b-3p DAAM1 1.16970507422762 6.85086072809354e-05 -0.4294466447742 0.327925739625826 MirTarget;miRNATAP -0.119223163450559 9.89442748145749e-05 NA NA NA hsa-miR-181a-5p DAAM1 0.206424802853514 0.833057626260378 -0.4294466447742 0.327925739625826 mirMAP -0.320622611303431 3.63286030739205e-15 NA NA NA hsa-miR-181b-5p DAAM1 0.515446560070718 0.50566125221377 -0.4294466447742 0.327925739625826 mirMAP -0.297706446427752 3.7202331187859e-18 NA NA NA hsa-miR-181c-5p DAAM1 0.287567602280886 0.587379107531716 -0.4294466447742 0.327925739625826 mirMAP -0.250470942223665 9.24701348872529e-13 NA NA NA hsa-miR-194-5p DAAM1 0.121400158256988 0.856838184584703 -0.4294466447742 0.327925739625826 miRNATAP -0.189174045503208 3.95432785140071e-05 NA NA NA hsa-miR-19a-3p DAAM1 1.46790979235261 0.000361171910570302 -0.4294466447742 0.327925739625826 miRNATAP -0.190478397802553 1.17645107395773e-12 NA NA NA hsa-miR-19b-3p DAAM1 1.16012277183793 0.0628519598637838 -0.4294466447742 0.327925739625826 miRNATAP -0.169719982996084 2.92738495486855e-07 NA NA NA hsa-miR-21-5p DAAM1 -0.142759573450327 0.928848736959803 -0.4294466447742 0.327925739625826 miRNAWalker2_validate -0.280306110680269 1.3190405082497e-14 NA NA NA hsa-miR-27a-3p DAAM1 0.628895559781173 0.490244908291708 -0.4294466447742 0.327925739625826 miRNATAP -0.214645452354381 2.10218326613165e-06 NA NA NA hsa-miR-29a-3p DAAM1 0.46338784979134 0.683743087347155 -0.4294466447742 0.327925739625826 MirTarget;miRNATAP -0.19764404076712 3.31620000413814e-06 NA NA NA hsa-miR-29b-3p DAAM1 0.271083597599281 0.740286663164405 -0.4294466447742 0.327925739625826 MirTarget;miRNATAP -0.149791302355507 4.83700986797815e-05 NA NA NA hsa-miR-29c-3p DAAM1 -0.643278710106618 0.522845109493165 -0.4294466447742 0.327925739625826 MirTarget;miRNATAP -0.152602454746229 2.18628177659896e-05 NA NA NA hsa-miR-32-5p DAAM1 0.531860098119996 0.195500436097555 -0.4294466447742 0.327925739625826 miRNATAP -0.184869801891824 6.4290036355108e-08 NA NA NA hsa-miR-320a DAAM1 0.241225090812918 0.773692094298861 -0.4294466447742 0.327925739625826 miRanda -0.164568986730623 0.00026548350856992 NA NA NA hsa-miR-500a-3p DAAM1 0.819125859525888 0.245855065392962 -0.4294466447742 0.327925739625826 MirTarget -0.182020512089716 2.32427170809983e-06 NA NA NA hsa-miR-590-3p DAAM1 1.01238246880436 6.25794947126089e-07 -0.4294466447742 0.327925739625826 MirTarget;miRanda;mirMAP -0.118654937699321 0.000263360597662213 NA NA NA hsa-miR-96-5p DAAM1 0.100415780625178 0.816616062681011 -0.4294466447742 0.327925739625826 TargetScan;miRNATAP -0.102839541953941 1.06315967280966e-05 NA NA NA hsa-miR-141-5p DAAM2 0.148357564860886 0.854593186542924 -0.0402745144958083 0.924877679800936 mirMAP -0.38681514285257 1.29341814943135e-41 NA NA NA hsa-miR-146b-5p DAAM2 0.876334790841257 0.284935762703604 -0.0402745144958083 0.924877679800936 miRanda -0.195815046000345 1.61868128738395e-06 NA NA NA hsa-miR-182-5p DAAM2 -0.350218686073308 0.794131834526037 -0.0402745144958083 0.924877679800936 mirMAP -0.428502281083267 1.77522555258754e-41 NA NA NA hsa-miR-18a-5p DAAM2 2.29585803678176 4.13931899001596e-14 -0.0402745144958083 0.924877679800936 miRNAWalker2_validate -0.128936539387179 3.13505694340858e-06 NA NA NA hsa-miR-193a-3p DAAM2 0.183521555169311 0.61877899263343 -0.0402745144958083 0.924877679800936 miRanda -0.165858100319702 0.000144893895245171 NA NA NA hsa-miR-19b-3p DAAM2 1.16012277183793 0.0628519598637838 -0.0402745144958083 0.924877679800936 miRNAWalker2_validate -0.131066070980346 0.000861544162814882 NA NA NA hsa-miR-429 DAAM2 0.448029985835258 0.437184735816941 -0.0402745144958083 0.924877679800936 miRNATAP -0.337876466411536 9.09263363484589e-41 NA NA NA hsa-miR-590-3p DAAM2 1.01238246880436 6.25794947126089e-07 -0.0402745144958083 0.924877679800936 miRanda;mirMAP -0.284734148563496 6.64083726278079e-14 NA NA NA hsa-miR-146b-5p DKK2 0.876334790841257 0.284935762703604 -0.755350562066212 0.00120111775391232 miRanda -0.214456904219556 4.16641532867677e-06 NA NA NA hsa-miR-193a-3p DKK2 0.183521555169311 0.61877899263343 -0.755350562066212 0.00120111775391232 miRanda -0.19209434845159 0.000113861738873523 NA NA NA hsa-miR-221-3p DKK2 0.889236679257595 0.165212011318271 -0.755350562066212 0.00120111775391232 miRNAWalker2_validate;miRTarBase -0.155357098507464 0.000547828614406337 NA NA NA hsa-miR-27a-3p DKK2 0.628895559781173 0.490244908291708 -0.755350562066212 0.00120111775391232 miRNATAP -0.243059240523354 7.10890941131857e-05 NA NA NA hsa-miR-324-5p DKK2 1.05212162375636 0.00665123910009839 -0.755350562066212 0.00120111775391232 miRanda -0.271141605871372 7.87002052167256e-13 NA NA NA hsa-miR-455-5p DKK2 1.38138264178539 0.00151082519157593 -0.755350562066212 0.00120111775391232 miRanda -0.333577119442953 4.85160924554831e-17 NA NA NA hsa-miR-576-5p DKK2 1.29396616748627 4.70941163094532e-05 -0.755350562066212 0.00120111775391232 mirMAP -0.200655010439433 1.08911792496519e-05 NA NA NA hsa-miR-590-3p DKK2 1.01238246880436 6.25794947126089e-07 -0.755350562066212 0.00120111775391232 miRanda;mirMAP;miRNATAP -0.294555133043718 1.22206770465475e-11 NA NA NA hsa-miR-590-5p DKK2 1.40236682288609 3.89322108176281e-06 -0.755350562066212 0.00120111775391232 miRanda -0.339389607211526 1.97063715460462e-16 NA NA NA hsa-miR-10a-5p DVL1 -1.07630188061982 0.423007718152432 0.195337907706659 0.722669803061579 miRNAWalker2_validate -0.107762545824595 6.19772338888115e-06 NA NA NA hsa-miR-30b-3p DVL1 0.353268230055879 0.0503719815958775 0.195337907706659 0.722669803061579 MirTarget -0.115579437179508 2.3800207966178e-05 NA NA NA hsa-miR-339-5p DVL1 0.176562373115907 0.71435382230926 0.195337907706659 0.722669803061579 miRanda -0.110559788670663 0.000220610270051997 NA NA NA hsa-let-7a-5p DVL3 -0.246449658252354 0.857810222667201 0.297656335739958 0.63257731059973 TargetScan -0.103667059737757 1.12037250327915e-06 NA NA NA hsa-miR-106b-5p EP300 1.04856358809711 0.139094273282727 -0.0549037964318266 0.928303175331622 miRNATAP -0.191649543350323 2.95239597393248e-13 NA NA NA hsa-miR-181b-5p EP300 0.515446560070718 0.50566125221377 -0.0549037964318266 0.928303175331622 miRNAWalker2_validate -0.187884049605316 7.93444158362854e-15 NA NA NA hsa-miR-20a-5p EP300 1.44423592705205 0.0465200458169632 -0.0549037964318266 0.928303175331622 miRNATAP -0.151748232339608 1.59846335234487e-12 NA NA NA hsa-miR-25-3p EP300 0.734786337660527 0.544331320304672 -0.0549037964318266 0.928303175331622 miRNAWalker2_validate -0.101950779775411 0.00585001386907759 NA NA NA hsa-miR-361-3p EP300 0.35229279501788 0.603486581638137 -0.0549037964318266 0.928303175331622 PITA -0.139187579360879 0.000249736724501524 NA NA NA hsa-miR-106b-5p FBXW11 1.04856358809711 0.139094273282727 -0.338167783081787 0.525288658644665 miRNATAP -0.176360910717368 7.82361659308432e-22 NA NA NA hsa-miR-20a-5p FBXW11 1.44423592705205 0.0465200458169632 -0.338167783081787 0.525288658644665 miRNATAP -0.144291334426437 6.70457379214045e-22 NA NA NA hsa-miR-340-5p FBXW11 0.362079103949629 0.350652374274417 -0.338167783081787 0.525288658644665 mirMAP -0.119257544627908 4.94445433521861e-11 NA NA NA hsa-miR-374a-5p FBXW11 0.47302975636239 0.309552532909276 -0.338167783081787 0.525288658644665 mirMAP -0.175519580181888 1.34257782586297e-12 NA NA NA hsa-miR-374b-5p FBXW11 0.478896841162915 0.365769179152496 -0.338167783081787 0.525288658644665 mirMAP -0.115315723202322 2.61335640229646e-06 NA NA NA hsa-miR-93-5p FBXW11 0.943892623097563 0.3984984603332 -0.338167783081787 0.525288658644665 miRNATAP -0.149796521194947 1.90586895576967e-16 NA NA NA hsa-miR-149-5p FOSL1 -1.45388658741237 0.0121158528554817 2.26372050140397 1.10214789227674e-19 MirTarget;miRNATAP -0.217220245133133 1.20539701452285e-10 NA NA NA hsa-miR-342-3p FOSL1 -0.720941204737844 0.328091715069398 2.26372050140397 1.10214789227674e-19 miRanda -0.403573240229472 2.83490772906014e-18 NA NA NA hsa-miR-1296-5p FRAT1 0.75427261447514 0.00404353477667648 -0.992001020253343 0.000638059194495603 MirTarget -0.202422777904563 2.39294268910508e-16 NA NA NA hsa-miR-23b-3p FRAT1 0.325018208255861 0.697275325712378 -0.992001020253343 0.000638059194495603 miRNATAP -0.272278749887034 6.57021937322535e-18 NA NA NA hsa-miR-125a-5p FRAT2 -0.142178978822393 0.87178508980574 0.239519435727487 0.550291126064545 miRanda -0.122529541273626 1.62004842950428e-05 NA NA NA hsa-miR-125b-5p FRAT2 0.0924748507064983 0.917738193990351 0.239519435727487 0.550291126064545 miRNAWalker2_validate;miRNATAP -0.211438805112806 1.43832131405049e-24 NA NA NA hsa-miR-22-3p FRAT2 0.0490135867272876 0.973443437320593 0.239519435727487 0.550291126064545 miRNAWalker2_validate;MirTarget;miRNATAP -0.282270676456224 8.71182980194614e-13 NA NA NA hsa-miR-26a-5p FRAT2 -0.0526989605494563 0.958167127738582 0.239519435727487 0.550291126064545 miRNATAP -0.149885015101282 3.81360261100518e-05 NA NA NA hsa-miR-337-3p FRAT2 -0.499643179619903 0.305573737113327 0.239519435727487 0.550291126064545 MirTarget;PITA -0.167553471806894 1.26273673886636e-24 NA NA NA hsa-miR-29b-3p FZD1 0.271083597599281 0.740286663164405 0.280849698370563 0.610014544265238 mirMAP -0.142292816540562 7.62954986745634e-06 NA NA NA hsa-miR-29c-3p FZD1 -0.643278710106618 0.522845109493165 0.280849698370563 0.610014544265238 mirMAP -0.218168403933287 1.2823801399907e-12 NA NA NA hsa-miR-107 FZD10 0.351433472692356 0.523819413335979 -0.299243475585232 0.163139309328814 miRanda -0.400790225805032 2.23315200602984e-08 NA NA NA hsa-miR-15b-5p FZD10 0.687228605707872 0.304427884697749 -0.299243475585232 0.163139309328814 miRNATAP -0.294791552759113 8.30312298544766e-09 NA NA NA hsa-miR-16-5p FZD10 0.608716035131087 0.441059798918702 -0.299243475585232 0.163139309328814 miRNATAP -0.205587202208207 0.000809635155549991 NA NA NA hsa-miR-25-3p FZD10 0.734786337660527 0.544331320304672 -0.299243475585232 0.163139309328814 miRNATAP -0.348866342513126 7.96845323691697e-06 NA NA NA hsa-miR-455-3p FZD10 1.81875409993265 0.00359686505068207 -0.299243475585232 0.163139309328814 PITA;miRNATAP -0.126579766449709 7.04423244264842e-05 NA NA NA hsa-miR-92a-3p FZD10 1.22719477478376 0.303128344063904 -0.299243475585232 0.163139309328814 miRNATAP -0.296950048447328 5.92314304840851e-07 NA NA NA hsa-miR-92b-3p FZD10 0.0724649458628939 0.903979460030041 -0.299243475585232 0.163139309328814 miRNATAP -0.138813280698489 0.00275447570293217 NA NA NA hsa-miR-98-5p FZD10 0.611305673326084 0.243973203190168 -0.299243475585232 0.163139309328814 miRNAWalker2_validate -0.461667265087064 4.29163451584181e-11 NA NA NA hsa-miR-103a-3p FZD3 -0.0705890709254717 0.957272313720577 -0.127208223317567 0.648530876806508 MirTarget -0.217217198769376 1.65600292637449e-05 NA NA NA hsa-miR-107 FZD3 0.351433472692356 0.523819413335979 -0.127208223317567 0.648530876806508 MirTarget;miRanda -0.179768540730773 0.00061594712979082 NA NA NA hsa-miR-139-5p FZD3 -0.292245043386175 0.603867611856128 -0.127208223317567 0.648530876806508 PITA;miRanda -0.114417639453248 1.43759918418206e-05 NA NA NA hsa-miR-16-2-3p FZD3 1.04875803256727 0.000133454779801128 -0.127208223317567 0.648530876806508 mirMAP -0.131652726734944 0.000136576830732616 NA NA NA hsa-miR-335-3p FZD3 0.20540439554909 0.735174242671502 -0.127208223317567 0.648530876806508 MirTarget;mirMAP -0.113655440180937 1.86044682903159e-05 NA NA NA hsa-miR-338-3p FZD3 -0.299081553502284 0.690790317255839 -0.127208223317567 0.648530876806508 PITA;miRanda -0.111182152623386 0.000317238435661394 NA NA NA hsa-miR-361-5p FZD3 0.295581181703002 0.679805903809273 -0.127208223317567 0.648530876806508 miRanda;miRNATAP -0.262866332902642 0.000447138915298169 NA NA NA hsa-miR-374a-5p FZD3 0.47302975636239 0.309552532909276 -0.127208223317567 0.648530876806508 mirMAP -0.182913725946331 0.00081843481388181 NA NA NA hsa-let-7a-3p FZD4 0.311896921808493 0.499509698073189 -0.757353288322241 0.186174262226182 mirMAP -0.407977804308959 4.19813220404563e-15 NA NA NA hsa-let-7d-5p FZD4 0.737311896446371 0.277996131668254 -0.757353288322241 0.186174262226182 MirTarget;miRNATAP -0.378548770288792 7.31572406282056e-13 NA NA NA hsa-let-7f-1-3p FZD4 0.541305090676599 0.000810726288280833 -0.757353288322241 0.186174262226182 mirMAP -0.196958732723448 1.81775392431145e-06 NA NA NA hsa-let-7g-3p FZD4 0.856197325425713 0.0358560037531409 -0.757353288322241 0.186174262226182 MirTarget;miRNATAP -0.181060509538746 5.2893212751556e-10 NA NA NA hsa-miR-106b-5p FZD4 1.04856358809711 0.139094273282727 -0.757353288322241 0.186174262226182 miRNATAP -0.578879980215605 3.05048677233544e-41 NA NA NA hsa-miR-107 FZD4 0.351433472692356 0.523819413335979 -0.757353288322241 0.186174262226182 miRNATAP -0.462830534136136 4.14785600961069e-16 NA NA NA hsa-miR-130b-3p FZD4 1.16970507422762 6.85086072809354e-05 -0.757353288322241 0.186174262226182 mirMAP -0.413297584170443 1.17616241857261e-31 NA NA NA hsa-miR-141-3p FZD4 0.518554136840043 0.543645265590794 -0.757353288322241 0.186174262226182 TargetScan -0.485144243770508 8.88244662789011e-86 NA NA NA hsa-miR-15a-5p FZD4 0.342480184869245 0.605040217513538 -0.757353288322241 0.186174262226182 MirTarget -0.396430785367124 8.19331587254851e-14 NA NA NA hsa-miR-15b-5p FZD4 0.687228605707872 0.304427884697749 -0.757353288322241 0.186174262226182 MirTarget -0.335171646720997 1.57029090717913e-16 NA NA NA hsa-miR-16-5p FZD4 0.608716035131087 0.441059798918702 -0.757353288322241 0.186174262226182 MirTarget -0.244461027478749 6.1956298490801e-07 NA NA NA hsa-miR-17-3p FZD4 1.46616632235897 0.0418591337484843 -0.757353288322241 0.186174262226182 MirTarget -0.488528178794328 1.80113152001825e-35 NA NA NA hsa-miR-17-5p FZD4 1.80801649919324 0.017740816345401 -0.757353288322241 0.186174262226182 TargetScan -0.379930791437764 1.81308518580408e-28 NA NA NA hsa-miR-185-5p FZD4 0.413180953895098 0.435464963453554 -0.757353288322241 0.186174262226182 MirTarget -0.32822571943949 2.4240703164448e-08 NA NA NA hsa-miR-192-5p FZD4 0.471716293688646 0.531156230462861 -0.757353288322241 0.186174262226182 miRNAWalker2_validate;mirMAP -0.417317983267879 3.23659392050309e-28 NA NA NA hsa-miR-200b-3p FZD4 0.224286846990266 0.786394257540977 -0.757353288322241 0.186174262226182 mirMAP -0.443472478111004 1.62241648876776e-56 NA NA NA hsa-miR-200c-3p FZD4 0.368794286773724 0.756435233803377 -0.757353288322241 0.186174262226182 mirMAP -0.5394698778619 2.40222703670541e-71 NA NA NA hsa-miR-20a-5p FZD4 1.44423592705205 0.0465200458169632 -0.757353288322241 0.186174262226182 miRNATAP -0.349126822049724 3.50595644995987e-22 NA NA NA hsa-miR-21-5p FZD4 -0.142759573450327 0.928848736959803 -0.757353288322241 0.186174262226182 mirMAP -0.617423104849022 4.14640575991911e-50 NA NA NA hsa-miR-212-3p FZD4 0.733470062196833 0.0007562475324171 -0.757353288322241 0.186174262226182 mirMAP -0.106820495464605 0.0061660372674424 NA NA NA hsa-miR-25-3p FZD4 0.734786337660527 0.544331320304672 -0.757353288322241 0.186174262226182 mirMAP -0.311311688515217 6.52111955612921e-07 NA NA NA hsa-miR-27a-3p FZD4 0.628895559781173 0.490244908291708 -0.757353288322241 0.186174262226182 miRNATAP -0.332335163103274 6.55789467955252e-10 NA NA NA hsa-miR-301a-3p FZD4 0.968506401137921 0.000570564850124159 -0.757353288322241 0.186174262226182 mirMAP -0.296293129313005 3.03122689456589e-26 NA NA NA hsa-miR-3065-3p FZD4 -0.215298286615624 0.657132844838708 -0.757353288322241 0.186174262226182 mirMAP -0.21363490263864 4.05907439854592e-17 NA NA NA hsa-miR-3127-5p FZD4 0.14676111885184 0.566846453082815 -0.757353288322241 0.186174262226182 MirTarget -0.353612933288253 8.25127810305334e-22 NA NA NA hsa-miR-32-5p FZD4 0.531860098119996 0.195500436097555 -0.757353288322241 0.186174262226182 mirMAP -0.393954741435993 7.79828021744844e-23 NA NA NA hsa-miR-324-3p FZD4 0.751526916869153 0.0436798222769339 -0.757353288322241 0.186174262226182 miRNATAP -0.308721358633824 3.19173797166468e-13 NA NA NA hsa-miR-330-5p FZD4 0.563423954500856 0.194785172695321 -0.757353288322241 0.186174262226182 miRanda;miRNATAP -0.413410414565267 1.56474033349077e-20 NA NA NA hsa-miR-361-3p FZD4 0.35229279501788 0.603486581638137 -0.757353288322241 0.186174262226182 MirTarget -0.210274672274026 0.00114713669929094 NA NA NA hsa-miR-429 FZD4 0.448029985835258 0.437184735816941 -0.757353288322241 0.186174262226182 mirMAP -0.419642690763874 1.62254290929758e-64 NA NA NA hsa-miR-454-3p FZD4 0.427403467632791 0.11673336658399 -0.757353288322241 0.186174262226182 mirMAP -0.33333483404347 1.07749136844395e-22 NA NA NA hsa-miR-455-3p FZD4 1.81875409993265 0.00359686505068207 -0.757353288322241 0.186174262226182 mirMAP -0.187203964079631 1.23489599175754e-13 NA NA NA hsa-miR-484 FZD4 0.411127332258218 0.453891011654088 -0.757353288322241 0.186174262226182 PITA -0.212116451539721 1.28850151052031e-06 NA NA NA hsa-miR-576-5p FZD4 1.29396616748627 4.70941163094532e-05 -0.757353288322241 0.186174262226182 mirMAP -0.1856965803836 4.20641790446917e-06 NA NA NA hsa-miR-582-5p FZD4 0.84770952065171 0.000866226913967834 -0.757353288322241 0.186174262226182 PITA;miRNATAP -0.128558705031842 0.000254827247268146 NA NA NA hsa-miR-590-3p FZD4 1.01238246880436 6.25794947126089e-07 -0.757353288322241 0.186174262226182 miRanda;mirMAP;miRNATAP -0.406671608133116 3.85657572987706e-27 NA NA NA hsa-miR-590-5p FZD4 1.40236682288609 3.89322108176281e-06 -0.757353288322241 0.186174262226182 mirMAP -0.331595766851545 7.67537979959466e-20 NA NA NA hsa-miR-629-3p FZD4 0.646784178673209 0.00160560935877895 -0.757353288322241 0.186174262226182 miRNATAP -0.23213209252431 2.89292527551865e-15 NA NA NA hsa-miR-7-1-3p FZD4 -0.136535237676745 0.726879891153832 -0.757353288322241 0.186174262226182 mirMAP -0.224934472313498 1.05455748906568e-09 NA NA NA hsa-miR-92a-3p FZD4 1.22719477478376 0.303128344063904 -0.757353288322241 0.186174262226182 mirMAP -0.301979533216699 2.02325930056432e-10 NA NA NA hsa-miR-92b-3p FZD4 0.0724649458628939 0.903979460030041 -0.757353288322241 0.186174262226182 mirMAP -0.348983639703719 6.88519966120482e-22 NA NA NA hsa-miR-98-5p FZD4 0.611305673326084 0.243973203190168 -0.757353288322241 0.186174262226182 MirTarget -0.528062971038367 1.52945921080448e-21 NA NA NA hsa-miR-194-5p FZD5 0.121400158256988 0.856838184584703 0.577958718501785 0.0503319152326712 miRNATAP -0.178831539257334 6.90395730167637e-05 NA NA NA hsa-miR-200a-3p FZD5 0.298946102269216 0.671358593831 0.577958718501785 0.0503319152326712 mirMAP -0.193303591193815 3.54560151752924e-19 NA NA NA hsa-miR-342-3p FZD5 -0.720941204737844 0.328091715069398 0.577958718501785 0.0503319152326712 PITA -0.25230820365646 7.06125013894829e-20 NA NA NA hsa-miR-450b-5p FZD5 0.191777880666372 0.614703205288598 0.577958718501785 0.0503319152326712 mirMAP -0.162494214108962 8.75558752610779e-07 NA NA NA hsa-miR-493-5p FZD5 -0.307290731911388 0.258023566102483 0.577958718501785 0.0503319152326712 mirMAP -0.148378073973601 4.37435544088392e-08 NA NA NA hsa-miR-101-3p FZD6 -0.115297778040423 0.925564544736514 0.84860367761873 0.0875121120398847 miRNAWalker2_validate;MirTarget -0.18427726420101 0.00071074749259132 NA NA NA hsa-miR-194-5p FZD6 0.121400158256988 0.856838184584703 0.84860367761873 0.0875121120398847 MirTarget -0.1574113672057 0.003131819177647 NA NA NA hsa-miR-192-5p FZD7 0.471716293688646 0.531156230462861 1.00317053789674 0.0640335436893371 miRNAWalker2_validate -0.161936601307415 7.47545781365299e-06 NA NA NA hsa-miR-338-3p FZD7 -0.299081553502284 0.690790317255839 1.00317053789674 0.0640335436893371 miRanda -0.141146838960966 7.12302368603286e-06 NA NA NA hsa-miR-429 FZD7 0.448029985835258 0.437184735816941 1.00317053789674 0.0640335436893371 miRanda;miRNATAP -0.118345789299754 1.70567166199748e-06 NA NA NA hsa-miR-590-3p FZD7 1.01238246880436 6.25794947126089e-07 1.00317053789674 0.0640335436893371 miRanda -0.113468728152917 0.0016315686222763 NA NA NA hsa-miR-324-5p FZD8 1.05212162375636 0.00665123910009839 0.180149729120512 0.658746351187227 miRanda -0.112580820578128 0.00139833151556216 NA NA NA hsa-miR-590-3p FZD8 1.01238246880436 6.25794947126089e-07 0.180149729120512 0.658746351187227 miRanda -0.187080083941158 3.36973671342903e-06 NA NA NA hsa-miR-7-1-3p FZD8 -0.136535237676745 0.726879891153832 0.180149729120512 0.658746351187227 MirTarget -0.285864089758394 6.15672183615667e-14 NA NA NA hsa-miR-99b-5p FZD8 0.17191840516915 0.898256959293391 0.180149729120512 0.658746351187227 MirTarget -0.27167361740119 1.84979575053296e-08 NA NA NA hsa-miR-101-3p GSK3B -0.115297778040423 0.925564544736514 0.00067099877911847 0.999040700038232 miRNATAP -0.1804025732635 1.07790099640944e-12 NA NA NA hsa-miR-181a-5p GSK3B 0.206424802853514 0.833057626260378 0.00067099877911847 0.999040700038232 mirMAP -0.116539047078398 1.93667948800215e-07 NA NA NA hsa-miR-26a-5p GSK3B -0.0526989605494563 0.958167127738582 0.00067099877911847 0.999040700038232 miRNAWalker2_validate;miRNATAP -0.275908606747704 3.58443650423207e-22 NA NA NA hsa-miR-29a-3p GSK3B 0.46338784979134 0.683743087347155 0.00067099877911847 0.999040700038232 miRNATAP -0.20395154397803 2.73691130456682e-19 NA NA NA hsa-miR-29c-3p GSK3B -0.643278710106618 0.522845109493165 0.00067099877911847 0.999040700038232 miRNATAP -0.148921210430456 1.24088422020447e-14 NA NA NA hsa-miR-320a GSK3B 0.241225090812918 0.773692094298861 0.00067099877911847 0.999040700038232 miRanda;mirMAP -0.129942826481556 1.0429094971177e-07 NA NA NA hsa-miR-340-5p GSK3B 0.362079103949629 0.350652374274417 0.00067099877911847 0.999040700038232 mirMAP -0.119708017508741 1.77864671732598e-09 NA NA NA hsa-miR-374a-5p GSK3B 0.47302975636239 0.309552532909276 0.00067099877911847 0.999040700038232 mirMAP -0.161835653986741 2.7137832607523e-09 NA NA NA hsa-miR-542-3p GSK3B 0.0492894440657814 0.946714392793758 0.00067099877911847 0.999040700038232 miRanda -0.110477181605807 5.02640445089489e-09 NA NA NA hsa-miR-141-3p JUN 0.518554136840043 0.543645265590794 -0.109002773092285 0.884881350387995 miRNATAP -0.26513026030347 4.33514873445987e-29 NA NA NA hsa-miR-155-5p JUN 1.12529442422533 0.131933535981501 -0.109002773092285 0.884881350387995 miRNAWalker2_validate;miRTarBase -0.151050894850655 5.76726631886013e-07 23693020 In the present study we demonstrated for the first time that activation of RAGE by S100P regulates oncogenic microRNA-155 miR-155 expression through Activator Protein-1 AP-1 stimulation in colon cancer cells colon cancer hsa-miR-16-5p JUN 0.608716035131087 0.441059798918702 -0.109002773092285 0.884881350387995 miRNAWalker2_validate -0.336111932326481 7.47849859844435e-15 NA NA NA hsa-miR-200a-3p JUN 0.298946102269216 0.671358593831 -0.109002773092285 0.884881350387995 miRNATAP -0.179081800592841 4.16743748553287e-14 NA NA NA hsa-miR-200b-3p JUN 0.224286846990266 0.786394257540977 -0.109002773092285 0.884881350387995 MirTarget;TargetScan -0.16460620647419 5.28647088864828e-10 NA NA NA hsa-miR-200c-3p JUN 0.368794286773724 0.756435233803377 -0.109002773092285 0.884881350387995 MirTarget -0.273188681953389 1.78966606345752e-21 NA NA NA hsa-miR-32-5p JUN 0.531860098119996 0.195500436097555 -0.109002773092285 0.884881350387995 miRNATAP -0.263951179853313 2.73587232573327e-13 NA NA NA hsa-miR-342-3p JUN -0.720941204737844 0.328091715069398 -0.109002773092285 0.884881350387995 miRNAWalker2_validate -0.199604605467411 5.91888161762324e-11 NA NA NA hsa-miR-429 JUN 0.448029985835258 0.437184735816941 -0.109002773092285 0.884881350387995 MirTarget;PITA;miRanda;miRNATAP -0.17100165827497 4.02284319393828e-13 NA NA NA hsa-miR-455-3p JUN 1.81875409993265 0.00359686505068207 -0.109002773092285 0.884881350387995 miRNATAP -0.147720631567845 5.98195601818343e-11 NA NA NA hsa-miR-590-3p JUN 1.01238246880436 6.25794947126089e-07 -0.109002773092285 0.884881350387995 miRanda -0.306481168731635 1.59764946185952e-19 NA NA NA hsa-miR-92a-3p JUN 1.22719477478376 0.303128344063904 -0.109002773092285 0.884881350387995 miRNATAP -0.138285339206201 0.00119119178853874 NA NA NA hsa-miR-92b-3p JUN 0.0724649458628939 0.903979460030041 -0.109002773092285 0.884881350387995 miRNATAP -0.135248670230231 4.27496884553493e-05 NA NA NA hsa-miR-93-5p JUN 0.943892623097563 0.3984984603332 -0.109002773092285 0.884881350387995 miRNAWalker2_validate -0.216264935663652 4.08318210776355e-08 NA NA NA hsa-miR-326 LEF1 0.215485710119405 0.487218662995766 -0.643047119850621 0.0926058860046028 miRanda -0.135291856721102 1.0203567859312e-06 NA NA NA hsa-miR-335-3p LEF1 0.20540439554909 0.735174242671502 -0.643047119850621 0.0926058860046028 mirMAP -0.25656991808437 2.69608203703196e-17 NA NA NA hsa-miR-15a-5p LRP6 0.342480184869245 0.605040217513538 0.535180874852075 0.308059727143743 miRNATAP -0.248475041752213 6.11710404479044e-12 NA NA NA hsa-miR-16-1-3p LRP6 0.416431607020454 0.0443663162632403 0.535180874852075 0.308059727143743 mirMAP -0.106034973608583 0.000270497356573657 NA NA NA hsa-miR-181a-5p LRP6 0.206424802853514 0.833057626260378 0.535180874852075 0.308059727143743 mirMAP -0.121798217084118 0.000280419813406394 NA NA NA hsa-miR-181b-5p LRP6 0.515446560070718 0.50566125221377 0.535180874852075 0.308059727143743 mirMAP -0.116284631040285 3.90842230631843e-05 NA NA NA hsa-miR-182-5p LRP6 -0.350218686073308 0.794131834526037 0.535180874852075 0.308059727143743 mirMAP -0.130168955655354 1.02975819358864e-08 NA NA NA hsa-miR-183-5p LRP6 0.204550384370393 0.863354421890003 0.535180874852075 0.308059727143743 miRNATAP -0.108472989759681 7.08115025900927e-08 24289859 MicroRNA 183 suppresses retinoblastoma cell growth invasion and migration by targeting LRP6; These results indicate that miR-183 targets and downregulates LRP6 in the growth migration and invasion of RB cells retinoblastoma hsa-miR-29c-3p LRP6 -0.643278710106618 0.522845109493165 0.535180874852075 0.308059727143743 miRNATAP -0.208977926908057 4.45236680313107e-13 NA NA NA hsa-miR-96-5p LRP6 0.100415780625178 0.816616062681011 0.535180874852075 0.308059727143743 TargetScan;miRNATAP -0.11391896975426 1.48551831367243e-09 NA NA NA hsa-miR-103a-3p MAP3K7 -0.0705890709254717 0.957272313720577 0.350367139930865 0.453761111724581 miRNAWalker2_validate -0.184281845409368 2.38036238656993e-13 NA NA NA hsa-miR-130b-3p MAPK10 1.16970507422762 6.85086072809354e-05 -0.143859111717503 0.649958288293509 miRNATAP -0.311198542431805 1.15998229401123e-08 NA NA NA hsa-miR-19a-3p MAPK10 1.46790979235261 0.000361171910570302 -0.143859111717503 0.649958288293509 miRNATAP -0.222702615462015 4.17842244233184e-06 NA NA NA hsa-miR-19b-3p MAPK10 1.16012277183793 0.0628519598637838 -0.143859111717503 0.649958288293509 miRNATAP -0.182028621380633 0.00223666160802019 NA NA NA hsa-miR-29b-3p MAPK10 0.271083597599281 0.740286663164405 -0.143859111717503 0.649958288293509 miRNATAP -0.214951327451731 0.00114851870928561 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-301a-3p MAPK10 0.968506401137921 0.000570564850124159 -0.143859111717503 0.649958288293509 miRNATAP -0.20354840914367 2.22032173676851e-06 NA NA NA hsa-miR-30d-3p MAPK10 0.267731984838241 0.27012774089276 -0.143859111717503 0.649958288293509 mirMAP -0.192664485965265 0.00899807954985931 NA NA NA hsa-miR-330-3p MAPK10 0.537733996157442 0.00592119172883149 -0.143859111717503 0.649958288293509 PITA;miRNATAP -0.240537820613709 6.0605250152691e-05 NA NA NA hsa-miR-429 MAPK10 0.448029985835258 0.437184735816941 -0.143859111717503 0.649958288293509 miRNATAP -0.366481358214565 1.02092652001284e-20 NA NA NA hsa-miR-454-3p MAPK10 0.427403467632791 0.11673336658399 -0.143859111717503 0.649958288293509 miRNATAP -0.269274577449595 2.23366460726875e-07 NA NA NA hsa-miR-455-5p MAPK10 1.38138264178539 0.00151082519157593 -0.143859111717503 0.649958288293509 miRanda -0.2052531701295 0.000129116493384105 NA NA NA hsa-miR-590-3p MAPK10 1.01238246880436 6.25794947126089e-07 -0.143859111717503 0.649958288293509 miRanda;mirMAP -0.323164263319335 2.39879463887196e-08 NA NA NA hsa-miR-590-5p MAPK10 1.40236682288609 3.89322108176281e-06 -0.143859111717503 0.649958288293509 PITA;miRanda;miRNATAP -0.208756960356003 0.000174508852265274 NA NA NA hsa-miR-107 MAPK8 0.351433472692356 0.523819413335979 0.135890279695962 0.686366474054282 miRNATAP -0.17791631045835 3.75913999690967e-05 NA NA NA hsa-miR-140-3p MAPK8 0.562212100226517 0.538115971474499 0.135890279695962 0.686366474054282 miRNAWalker2_validate -0.18488366577202 2.13922359684877e-08 NA NA NA hsa-miR-214-3p MAPK8 -0.325381001148475 0.257166731470048 0.135890279695962 0.686366474054282 miRNAWalker2_validate -0.131663145030191 2.77448993612092e-07 19859982 HeLa cells that stably overexpress miR-214 downregulate the expression of MEK3 and JNK1 at both mRNA and protein levels; Further investigation revealed that miR-214 regulates the expression of MEK3 and JNK1 by targeting the 3'UTRs of these genes; Collectively these results suggest that miR-214 negatively regulates HeLa cell proliferation by targeting the noncoding regions of MEK3 and JNK1 mRNAs cervical and endocervical cancer hsa-miR-22-5p MAPK8 0.386811466292275 0.351646252133174 0.135890279695962 0.686366474054282 mirMAP -0.111645018994966 0.000421521825972328 NA NA NA hsa-miR-361-5p MAPK8 0.295581181703002 0.679805903809273 0.135890279695962 0.686366474054282 PITA;miRanda;mirMAP -0.36263548128247 3.21553639920568e-09 NA NA NA hsa-let-7i-5p MAPK9 0.491983487993952 0.539800598932235 -0.540218297464117 0.314045694916616 miRNATAP -0.306833929478603 2.50065627421339e-17 NA NA NA hsa-miR-20a-5p MAPK9 1.44423592705205 0.0465200458169632 -0.540218297464117 0.314045694916616 miRNAWalker2_validate;miRNATAP -0.149791797617831 1.16802726117118e-19 NA NA NA hsa-miR-361-5p MAPK9 0.295581181703002 0.679805903809273 -0.540218297464117 0.314045694916616 miRanda -0.302539307267532 3.19615101156316e-16 NA NA NA hsa-miR-374a-5p MAPK9 0.47302975636239 0.309552532909276 -0.540218297464117 0.314045694916616 mirMAP -0.208569547789819 1.38505915980085e-14 NA NA NA hsa-miR-374b-5p MAPK9 0.478896841162915 0.365769179152496 -0.540218297464117 0.314045694916616 mirMAP -0.162602292754305 1.32462729456077e-09 NA NA NA hsa-miR-92a-3p MAPK9 1.22719477478376 0.303128344063904 -0.540218297464117 0.314045694916616 miRNAWalker2_validate -0.159802962706798 1.32672396914361e-13 NA NA NA hsa-miR-21-5p MYC -0.142759573450327 0.928848736959803 0.683231218937876 0.28627588440922 miRNAWalker2_validate -0.270190862069706 5.76701615920235e-10 22072622 In contrast the levels of β-catenin TCF/LEF activity and the expression of c-Myc Cyclin-D which are increased in CSCs are also augmented in miR-21 overexpressing colon cancer cells accompanied by an increased sphere forming ability in vitro and tumor formation in SCID mice colon cancer hsa-miR-34a-5p MYC 0.0116188317991073 0.985685717648123 0.683231218937876 0.28627588440922 miRNAWalker2_validate;miRTarBase -0.216308870548993 0.000129276161670072 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 0.448029985835258 0.437184735816941 0.683231218937876 0.28627588440922 miRNAWalker2_validate -0.108453248703558 4.76591679996824e-05 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-103a-3p NFAT5 -0.0705890709254717 0.957272313720577 0.248676186408694 0.656020689400483 MirTarget -0.336653367297422 1.28063362403024e-24 NA NA NA hsa-miR-106b-5p NFAT5 1.04856358809711 0.139094273282727 0.248676186408694 0.656020689400483 MirTarget;miRNATAP -0.23715765114845 1.20613671461126e-18 NA NA NA hsa-miR-107 NFAT5 0.351433472692356 0.523819413335979 0.248676186408694 0.656020689400483 MirTarget -0.295966190654869 8.65322066760854e-18 NA NA NA hsa-miR-1301-3p NFAT5 1.13236779080729 0.00035660210335027 0.248676186408694 0.656020689400483 MirTarget -0.114089558751608 4.42769113606664e-09 NA NA NA hsa-miR-141-3p NFAT5 0.518554136840043 0.543645265590794 0.248676186408694 0.656020689400483 mirMAP -0.149337877858226 6.05474618072504e-20 NA NA NA hsa-miR-148b-3p NFAT5 0.139560003671114 0.825716083905455 0.248676186408694 0.656020689400483 miRNATAP -0.132221606001518 1.3758614517174e-05 NA NA NA hsa-miR-155-5p NFAT5 1.12529442422533 0.131933535981501 0.248676186408694 0.656020689400483 mirMAP;miRNATAP -0.100566120170304 1.0444676030806e-06 NA NA NA hsa-miR-15a-5p NFAT5 0.342480184869245 0.605040217513538 0.248676186408694 0.656020689400483 MirTarget -0.336948547662713 2.05581015414347e-26 NA NA NA hsa-miR-16-1-3p NFAT5 0.416431607020454 0.0443663162632403 0.248676186408694 0.656020689400483 mirMAP -0.204713975377917 1.41977903192804e-15 NA NA NA hsa-miR-17-3p NFAT5 1.46616632235897 0.0418591337484843 0.248676186408694 0.656020689400483 mirMAP -0.129870741981494 1.53941711137671e-07 NA NA NA hsa-miR-181a-5p NFAT5 0.206424802853514 0.833057626260378 0.248676186408694 0.656020689400483 MirTarget;miRNATAP -0.187828472037995 2.67099255156267e-10 NA NA NA hsa-miR-181b-5p NFAT5 0.515446560070718 0.50566125221377 0.248676186408694 0.656020689400483 MirTarget;miRNATAP -0.21216357383761 1.4174363007063e-17 NA NA NA hsa-miR-194-5p NFAT5 0.121400158256988 0.856838184584703 0.248676186408694 0.656020689400483 miRNATAP -0.127013805342984 0.000142318500250381 NA NA NA hsa-miR-200a-3p NFAT5 0.298946102269216 0.671358593831 0.248676186408694 0.656020689400483 mirMAP -0.120533278835972 8.59748977733914e-14 NA NA NA hsa-miR-21-3p NFAT5 0.115900341574742 0.904443786801208 0.248676186408694 0.656020689400483 MirTarget -0.182888478641974 1.86723394339074e-16 NA NA NA hsa-miR-21-5p NFAT5 -0.142759573450327 0.928848736959803 0.248676186408694 0.656020689400483 miRNAWalker2_validate;mirMAP -0.34259926440926 2.90805980799457e-41 NA NA NA hsa-miR-32-5p NFAT5 0.531860098119996 0.195500436097555 0.248676186408694 0.656020689400483 miRNATAP -0.186203151817271 3.61328449313256e-14 NA NA NA hsa-miR-340-5p NFAT5 0.362079103949629 0.350652374274417 0.248676186408694 0.656020689400483 MirTarget -0.253446045615689 2.48815325036697e-22 NA NA NA hsa-miR-361-5p NFAT5 0.295581181703002 0.679805903809273 0.248676186408694 0.656020689400483 MirTarget;PITA;mirMAP;miRNATAP -0.133459394718286 0.00775411722566547 NA NA NA hsa-miR-3613-5p NFAT5 0.517041196647739 0.0834191155982057 0.248676186408694 0.656020689400483 miRNATAP -0.103018827085653 2.39140009917872e-05 NA NA NA hsa-miR-374a-3p NFAT5 0.47806575213705 0.580820043553098 0.248676186408694 0.656020689400483 mirMAP -0.114187577439033 0.00184299941974274 NA NA NA hsa-miR-429 NFAT5 0.448029985835258 0.437184735816941 0.248676186408694 0.656020689400483 miRNATAP -0.139784505249335 1.85265208110627e-18 NA NA NA hsa-miR-590-3p NFAT5 1.01238246880436 6.25794947126089e-07 0.248676186408694 0.656020689400483 MirTarget;miRanda;mirMAP;miRNATAP -0.100697433581401 1.88485706745528e-05 NA NA NA hsa-miR-92b-3p NFAT5 0.0724649458628939 0.903979460030041 0.248676186408694 0.656020689400483 miRNATAP -0.163288708475086 2.29328643304621e-13 NA NA NA hsa-miR-93-5p NFAT5 0.943892623097563 0.3984984603332 0.248676186408694 0.656020689400483 MirTarget;miRNATAP -0.248552951648198 4.68674105390296e-21 NA NA NA hsa-miR-3127-5p NFATC1 0.14676111885184 0.566846453082815 0.32718182794098 0.450224450665534 MirTarget -0.189661265640464 2.21630997061407e-12 NA NA NA hsa-miR-182-5p NFATC2 -0.350218686073308 0.794131834526037 -0.403723192975259 0.136549575851534 mirMAP -0.319993630027942 3.80744800734882e-10 NA NA NA hsa-miR-185-5p NFATC2 0.413180953895098 0.435464963453554 -0.403723192975259 0.136549575851534 MirTarget -0.480154397877674 9.64194904728437e-08 NA NA NA hsa-miR-19a-3p NFATC2 1.46790979235261 0.000361171910570302 -0.403723192975259 0.136549575851534 mirMAP -0.325063324024532 3.38278468154619e-11 NA NA NA hsa-miR-19b-3p NFATC2 1.16012277183793 0.0628519598637838 -0.403723192975259 0.136549575851534 mirMAP -0.287342497987003 2.05092326956767e-06 NA NA NA hsa-miR-200b-5p NFATC2 0.608100479305186 0.0928041357682558 -0.403723192975259 0.136549575851534 mirMAP -0.148120269747522 0.0033400668976821 NA NA NA hsa-miR-320b NFATC2 0.712468682578545 0.00260489977004221 -0.403723192975259 0.136549575851534 MirTarget -0.160231542240436 0.00642139736942507 NA NA NA hsa-miR-340-5p NFATC2 0.362079103949629 0.350652374274417 -0.403723192975259 0.136549575851534 miRNATAP -0.377355443179726 1.70562760392822e-08 NA NA NA hsa-miR-3613-5p NFATC2 0.517041196647739 0.0834191155982057 -0.403723192975259 0.136549575851534 mirMAP -0.344189531636949 1.85303094879685e-08 NA NA NA hsa-miR-423-5p NFATC2 0.0236430665584146 0.964184751182986 -0.403723192975259 0.136549575851534 PITA -0.329350686391576 0.000107038916546868 NA NA NA hsa-miR-590-3p NFATC2 1.01238246880436 6.25794947126089e-07 -0.403723192975259 0.136549575851534 mirMAP -0.207787840865524 0.000469613853353843 NA NA NA hsa-miR-15a-5p NFATC3 0.342480184869245 0.605040217513538 0.28948862320587 0.530424138294151 MirTarget;miRNATAP -0.231009103502432 3.55309483569134e-22 NA NA NA hsa-miR-185-5p NFATC3 0.413180953895098 0.435464963453554 0.28948862320587 0.530424138294151 MirTarget;miRNATAP -0.124879744848212 3.18788249333561e-06 NA NA NA hsa-miR-29c-3p NFATC3 -0.643278710106618 0.522845109493165 0.28948862320587 0.530424138294151 MirTarget;miRNATAP -0.133798476713389 4.59205597740966e-12 NA NA NA hsa-miR-340-5p NFATC3 0.362079103949629 0.350652374274417 0.28948862320587 0.530424138294151 MirTarget -0.153252771292197 7.73680776852044e-15 NA NA NA hsa-miR-361-5p NFATC3 0.295581181703002 0.679805903809273 0.28948862320587 0.530424138294151 miRanda -0.178329966960041 1.80837796087919e-06 NA NA NA hsa-miR-130b-5p NFATC4 1.3947936173305 4.50465898911354e-07 -1.30726255124792 0.0139339204728638 mirMAP -0.273306003041798 2.37279973423709e-19 NA NA NA hsa-miR-150-5p NFATC4 1.16771122623924 0.175252906436503 -1.30726255124792 0.0139339204728638 mirMAP -0.127353989190525 5.08033729715864e-08 NA NA NA hsa-miR-15b-3p NFATC4 1.33683404747498 0.00122709276757981 -1.30726255124792 0.0139339204728638 mirMAP -0.238062507407611 4.12345167097552e-14 NA NA NA hsa-miR-181a-2-3p NFATC4 0.682351266467006 0.429599916993576 -1.30726255124792 0.0139339204728638 mirMAP -0.265900817473076 5.67846111588394e-07 NA NA NA hsa-miR-185-3p NFATC4 1.02296406566789 2.42658505261776e-06 -1.30726255124792 0.0139339204728638 MirTarget -0.221463917308086 4.38182247561287e-11 NA NA NA hsa-miR-2355-5p NFATC4 0.516125245105019 0.301078573145612 -1.30726255124792 0.0139339204728638 MirTarget -0.314673921460914 7.76236682155888e-11 NA NA NA hsa-miR-29a-3p NFATC4 0.46338784979134 0.683743087347155 -1.30726255124792 0.0139339204728638 miRNATAP -0.159424686343472 0.00138862402245239 NA NA NA hsa-miR-29b-3p NFATC4 0.271083597599281 0.740286663164405 -1.30726255124792 0.0139339204728638 miRNATAP -0.122774285938033 0.00449585095871782 NA NA NA hsa-miR-3607-3p NFATC4 -0.0336542423413588 0.943687112266464 -1.30726255124792 0.0139339204728638 miRNATAP -0.103148919948283 1.40847070939603e-05 NA NA NA hsa-miR-361-3p NFATC4 0.35229279501788 0.603486581638137 -1.30726255124792 0.0139339204728638 mirMAP -0.221299437804629 0.000469274259610322 NA NA NA hsa-miR-484 NFATC4 0.411127332258218 0.453891011654088 -1.30726255124792 0.0139339204728638 MirTarget;miRNATAP -0.195541918029345 5.21748391548856e-06 NA NA NA hsa-miR-532-5p NFATC4 0.837154623550648 0.324129802476266 -1.30726255124792 0.0139339204728638 mirMAP -0.351153097111496 2.13922805026231e-12 NA NA NA hsa-miR-629-3p NFATC4 0.646784178673209 0.00160560935877895 -1.30726255124792 0.0139339204728638 mirMAP -0.222553384296637 1.10177313904365e-14 NA NA NA hsa-let-7a-5p NKD1 -0.246449658252354 0.857810222667201 -0.276568549799171 0.11540842237609 TargetScan -0.285119479952564 1.26690218381995e-05 NA NA NA hsa-miR-125a-5p NKD1 -0.142178978822393 0.87178508980574 -0.276568549799171 0.11540842237609 miRanda -0.278399457854937 1.03346527875826e-07 NA NA NA hsa-miR-361-5p NKD1 0.295581181703002 0.679805903809273 -0.276568549799171 0.11540842237609 miRanda -0.242196570817123 0.00520088014824435 NA NA NA hsa-let-7i-5p NLK 0.491983487993952 0.539800598932235 -0.495551021243264 0.250356691034228 miRNATAP -0.413862391863088 2.49706725878225e-22 NA NA NA hsa-miR-132-3p NLK 0.240816226207972 0.678532290124258 -0.495551021243264 0.250356691034228 miRNATAP -0.147434106687348 1.72134800695252e-06 NA NA NA hsa-miR-139-5p NLK -0.292245043386175 0.603867611856128 -0.495551021243264 0.250356691034228 miRanda -0.103239444031536 3.35421799377228e-11 NA NA NA hsa-miR-140-5p NLK 0.781948085004431 0.101152958138705 -0.495551021243264 0.250356691034228 MirTarget;PITA;miRanda;miRNATAP -0.139208185186153 3.98951586060413e-08 NA NA NA hsa-miR-146b-5p NLK 0.876334790841257 0.284935762703604 -0.495551021243264 0.250356691034228 miRanda -0.130772865651309 3.748420957412e-09 NA NA NA hsa-miR-152-3p NLK 0.0328154767845756 0.963193449314416 -0.495551021243264 0.250356691034228 MirTarget -0.121964596915363 5.58054397729548e-06 NA NA NA hsa-miR-195-3p NLK -0.148955193954253 0.573960981017585 -0.495551021243264 0.250356691034228 mirMAP -0.145388282098103 3.0064135076299e-11 NA NA NA hsa-miR-199b-5p NLK -0.489883928472198 0.514360594242384 -0.495551021243264 0.250356691034228 MirTarget;PITA;miRanda;miRNATAP -0.130208304038465 2.10468258720444e-11 NA NA NA hsa-miR-217 NLK 0.468063318648715 0.245270563056356 -0.495551021243264 0.250356691034228 miRanda -0.107421092941157 6.83560697467638e-11 NA NA NA hsa-miR-221-3p NLK 0.889236679257595 0.165212011318271 -0.495551021243264 0.250356691034228 MirTarget;miRNATAP -0.160004395790496 4.50992101797211e-14 NA NA NA hsa-miR-24-3p NLK 0.834102408142648 0.36961872772158 -0.495551021243264 0.250356691034228 miRNATAP -0.110962647460226 4.40407432880344e-05 NA NA NA hsa-miR-25-3p NLK 0.734786337660527 0.544331320304672 -0.495551021243264 0.250356691034228 MirTarget;miRNATAP -0.106492227212925 0.0017026454555609 NA NA NA hsa-miR-26a-5p NLK -0.0526989605494563 0.958167127738582 -0.495551021243264 0.250356691034228 miRNATAP -0.184587948058077 8.44159773363628e-08 NA NA NA hsa-miR-27a-3p NLK 0.628895559781173 0.490244908291708 -0.495551021243264 0.250356691034228 miRNATAP -0.108956811004123 0.000196776667929282 NA NA NA hsa-miR-27b-3p NLK 0.31299864801146 0.712470214220383 -0.495551021243264 0.250356691034228 miRNATAP -0.115578430021538 2.04956118003642e-05 NA NA NA hsa-miR-28-5p NLK 0.698472090600538 0.237744307568605 -0.495551021243264 0.250356691034228 miRanda -0.182841180159811 4.4803820168759e-07 NA NA NA hsa-miR-381-3p NLK -0.039202467729222 0.936304264987666 -0.495551021243264 0.250356691034228 MirTarget -0.176789380063327 1.23463667918594e-19 NA NA NA hsa-miR-455-5p NLK 1.38138264178539 0.00151082519157593 -0.495551021243264 0.250356691034228 MirTarget;PITA;miRanda;miRNATAP -0.123543532954721 1.15133287100025e-10 NA NA NA hsa-miR-485-3p NLK 0.0755008543866269 0.751124972921196 -0.495551021243264 0.250356691034228 MirTarget;PITA;miRNATAP -0.115025747481124 5.816614344041e-09 NA NA NA hsa-miR-92a-3p NLK 1.22719477478376 0.303128344063904 -0.495551021243264 0.250356691034228 MirTarget;miRNATAP -0.108248489207265 2.75005198560074e-05 NA NA NA hsa-miR-106b-5p PLCB1 1.04856358809711 0.139094273282727 -0.0673741770895395 0.858739825346359 miRNATAP -0.353580999854292 7.45108046911457e-10 NA NA NA hsa-miR-107 PLCB1 0.351433472692356 0.523819413335979 -0.0673741770895395 0.858739825346359 PITA;miRanda;miRNATAP -0.43540927048432 3.17440164078589e-09 NA NA NA hsa-miR-130b-3p PLCB1 1.16970507422762 6.85086072809354e-05 -0.0673741770895395 0.858739825346359 miRNATAP -0.196209100856761 2.76427536384308e-05 NA NA NA hsa-miR-16-2-3p PLCB1 1.04875803256727 0.000133454779801128 -0.0673741770895395 0.858739825346359 mirMAP -0.181891575863844 0.000186734623561594 NA NA NA hsa-miR-17-5p PLCB1 1.80801649919324 0.017740816345401 -0.0673741770895395 0.858739825346359 TargetScan;miRNATAP -0.14694574384319 0.00121463038460002 NA NA NA hsa-miR-19a-3p PLCB1 1.46790979235261 0.000361171910570302 -0.0673741770895395 0.858739825346359 miRNATAP -0.133824099939887 0.00125180775640206 NA NA NA hsa-miR-20a-5p PLCB1 1.44423592705205 0.0465200458169632 -0.0673741770895395 0.858739825346359 miRNATAP -0.199775783667376 2.30541192654188e-05 NA NA NA hsa-miR-301a-3p PLCB1 0.968506401137921 0.000570564850124159 -0.0673741770895395 0.858739825346359 miRNATAP -0.142645627899033 0.000107371010712177 NA NA NA hsa-miR-340-5p PLCB1 0.362079103949629 0.350652374274417 -0.0673741770895395 0.858739825346359 mirMAP -0.145430096241242 0.00999016493511445 NA NA NA hsa-miR-429 PLCB1 0.448029985835258 0.437184735816941 -0.0673741770895395 0.858739825346359 miRNATAP -0.224224441826941 4.11678198698433e-11 NA NA NA hsa-miR-454-3p PLCB1 0.427403467632791 0.11673336658399 -0.0673741770895395 0.858739825346359 miRNATAP -0.199095150598467 7.7170942260896e-06 NA NA NA hsa-miR-590-3p PLCB1 1.01238246880436 6.25794947126089e-07 -0.0673741770895395 0.858739825346359 PITA;miRanda;mirMAP -0.163197561436935 0.00104240143511447 NA NA NA hsa-miR-93-5p PLCB1 0.943892623097563 0.3984984603332 -0.0673741770895395 0.858739825346359 miRNATAP -0.375873317446529 2.70002798262841e-11 NA NA NA hsa-let-7b-5p PLCB3 -0.33051080473807 0.801061323852234 0.269940447991067 0.596181721215933 miRNAWalker2_validate -0.16887583502616 4.06103235376535e-11 NA NA NA hsa-miR-125a-5p PLCB3 -0.142178978822393 0.87178508980574 0.269940447991067 0.596181721215933 miRanda -0.184282319096659 4.86720731110882e-12 NA NA NA hsa-let-7a-3p PLCB4 0.311896921808493 0.499509698073189 1.17834872162196 0.00352772881364735 mirMAP;miRNATAP -0.19467309283188 0.00578258252733417 NA NA NA hsa-miR-141-3p PLCB4 0.518554136840043 0.543645265590794 1.17834872162196 0.00352772881364735 TargetScan -0.129122335963341 0.000435434137519319 NA NA NA hsa-miR-429 PLCB4 0.448029985835258 0.437184735816941 1.17834872162196 0.00352772881364735 miRanda -0.132358033926964 0.00021397529104974 NA NA NA hsa-miR-96-5p PLCB4 0.100415780625178 0.816616062681011 1.17834872162196 0.00352772881364735 TargetScan;miRNATAP -0.157435127267557 2.40435360053082e-05 NA NA NA hsa-miR-29c-3p PPARD -0.643278710106618 0.522845109493165 0.700160864741028 0.174814216074588 miRNATAP -0.128141556480419 7.98900291845159e-11 NA NA NA hsa-miR-497-5p PPARD 0.0181393084471777 0.96777886220216 0.700160864741028 0.174814216074588 mirMAP -0.108496813581842 2.57101128829637e-09 NA NA NA hsa-miR-17-3p PPP2CA 1.46616632235897 0.0418591337484843 -0.411601313247206 0.531629492275857 MirTarget -0.133330530645377 1.5958296816568e-20 NA NA NA hsa-miR-425-5p PPP2CB -0.236104424794897 0.745311621217506 -0.0328339344588384 0.955423855609641 miRNAWalker2_validate -0.1434305833926 3.027811361313e-18 NA NA NA hsa-miR-590-3p PPP2CB 1.01238246880436 6.25794947126089e-07 -0.0328339344588384 0.955423855609641 miRanda -0.10511834935696 4.0251015210593e-09 NA NA NA hsa-miR-128-3p PPP2R1B 0.710297676207337 0.257425866565775 0.321992608755617 0.507424999578933 MirTarget -0.109583188561297 0.000963818534703709 NA NA NA hsa-miR-146b-5p PPP2R1B 0.876334790841257 0.284935762703604 0.321992608755617 0.507424999578933 miRanda -0.141184532696467 1.00140046078863e-07 NA NA NA hsa-miR-15a-5p PPP2R1B 0.342480184869245 0.605040217513538 0.321992608755617 0.507424999578933 MirTarget -0.195736754254626 1.30304715741401e-08 NA NA NA hsa-miR-200b-3p PPP2R1B 0.224286846990266 0.786394257540977 0.321992608755617 0.507424999578933 MirTarget -0.190114683335312 5.20726875191601e-24 NA NA NA hsa-miR-200c-3p PPP2R1B 0.368794286773724 0.756435233803377 0.321992608755617 0.507424999578933 MirTarget -0.226923946553815 2.68646974148231e-28 21248297 Western blotting showed that knockdown of miR-200c expression was associated with increased expression of PPP2R1B a subunit of protein phosphatase 2A which resulted in reduced expression of phospho-Akt esophageal cancer hsa-miR-30d-3p PPP2R1B 0.267731984838241 0.27012774089276 0.321992608755617 0.507424999578933 mirMAP -0.157184793756038 6.17261426855798e-07 NA NA NA hsa-miR-429 PPP2R1B 0.448029985835258 0.437184735816941 0.321992608755617 0.507424999578933 MirTarget;miRanda;miRNATAP -0.148415458438853 1.78268855237664e-18 NA NA NA hsa-miR-107 PPP2R5A 0.351433472692356 0.523819413335979 -0.432191061546663 0.483553442641894 miRanda -0.116676163127242 0.000291888356596273 NA NA NA hsa-miR-455-5p PPP2R5A 1.38138264178539 0.00151082519157593 -0.432191061546663 0.483553442641894 miRanda -0.148237717752069 5.19586125294051e-14 NA NA NA hsa-miR-132-3p PPP2R5E 0.240816226207972 0.678532290124258 -0.11093062617899 0.808255495902328 MirTarget -0.117209424280952 5.86934317627525e-05 NA NA NA hsa-miR-146b-5p PPP2R5E 0.876334790841257 0.284935762703604 -0.11093062617899 0.808255495902328 miRanda -0.108519433912314 2.38654321669596e-07 NA NA NA hsa-miR-181a-5p PPP2R5E 0.206424802853514 0.833057626260378 -0.11093062617899 0.808255495902328 MirTarget;mirMAP -0.172705968640064 4.32215395940648e-12 NA NA NA hsa-miR-181b-5p PPP2R5E 0.515446560070718 0.50566125221377 -0.11093062617899 0.808255495902328 MirTarget;mirMAP -0.122508311764402 6.82476700676191e-09 NA NA NA hsa-miR-181c-5p PPP2R5E 0.287567602280886 0.587379107531716 -0.11093062617899 0.808255495902328 MirTarget;mirMAP -0.122046895343518 1.35193024529625e-08 NA NA NA hsa-miR-361-5p PPP2R5E 0.295581181703002 0.679805903809273 -0.11093062617899 0.808255495902328 miRanda -0.362844376404808 1.47810752731031e-18 NA NA NA hsa-miR-374a-3p PPP2R5E 0.47806575213705 0.580820043553098 -0.11093062617899 0.808255495902328 MirTarget -0.108150800102799 0.000444740858970142 NA NA NA hsa-miR-374a-5p PPP2R5E 0.47302975636239 0.309552532909276 -0.11093062617899 0.808255495902328 mirMAP -0.175200740577251 9.34615884892216e-09 NA NA NA hsa-miR-381-3p PPP2R5E -0.039202467729222 0.936304264987666 -0.11093062617899 0.808255495902328 MirTarget;mirMAP -0.104778657482713 2.09043362809501e-08 NA NA NA hsa-miR-455-5p PPP2R5E 1.38138264178539 0.00151082519157593 -0.11093062617899 0.808255495902328 miRanda -0.1463471269634 3.89164487655405e-16 NA NA NA hsa-miR-542-3p PPP2R5E 0.0492894440657814 0.946714392793758 -0.11093062617899 0.808255495902328 miRanda -0.14687324447004 3.28141828349973e-12 NA NA NA hsa-let-7f-5p PPP3CA 0.0370257574833044 0.975000297534477 -0.045650396271899 0.933852208885986 miRNATAP -0.102194254433793 0.00165189815382032 NA NA NA hsa-miR-106b-5p PPP3CA 1.04856358809711 0.139094273282727 -0.045650396271899 0.933852208885986 miRNATAP -0.163746270795427 4.48730421523751e-08 NA NA NA hsa-miR-17-3p PPP3CA 1.46616632235897 0.0418591337484843 -0.045650396271899 0.933852208885986 MirTarget -0.124078923715287 5.08318296663462e-06 NA NA NA hsa-miR-194-5p PPP3CA 0.121400158256988 0.856838184584703 -0.045650396271899 0.933852208885986 MirTarget -0.132376274530416 0.000303144003211118 NA NA NA hsa-miR-20a-5p PPP3CA 1.44423592705205 0.0465200458169632 -0.045650396271899 0.933852208885986 miRNATAP -0.110326267376209 6.81988772591416e-06 NA NA NA hsa-miR-21-5p PPP3CA -0.142759573450327 0.928848736959803 -0.045650396271899 0.933852208885986 miRNATAP -0.171857455775929 3.70280677648987e-09 NA NA NA hsa-miR-340-5p PPP3CA 0.362079103949629 0.350652374274417 -0.045650396271899 0.933852208885986 mirMAP -0.176067551771713 1.43168876315375e-09 NA NA NA hsa-miR-361-5p PPP3CA 0.295581181703002 0.679805903809273 -0.045650396271899 0.933852208885986 miRanda -0.244052441662145 8.38230854446672e-06 NA NA NA hsa-miR-93-5p PPP3CA 0.943892623097563 0.3984984603332 -0.045650396271899 0.933852208885986 miRNATAP -0.162948227314112 3.15959129159339e-08 NA NA NA hsa-miR-107 PPP3CB 0.351433472692356 0.523819413335979 -0.482174159044146 0.386570668476713 miRanda -0.128823034238509 4.39638835494672e-08 NA NA NA hsa-miR-146b-5p PPP3CB 0.876334790841257 0.284935762703604 -0.482174159044146 0.386570668476713 miRanda -0.171198371090796 2.36585494803099e-25 NA NA NA hsa-miR-15a-5p PPP3CB 0.342480184869245 0.605040217513538 -0.482174159044146 0.386570668476713 miRNATAP -0.126089090631579 8.14069089424982e-09 NA NA NA hsa-miR-340-5p PPP3CB 0.362079103949629 0.350652374274417 -0.482174159044146 0.386570668476713 MirTarget -0.156446625862705 8.32036945224755e-19 NA NA NA hsa-miR-361-5p PPP3CB 0.295581181703002 0.679805903809273 -0.482174159044146 0.386570668476713 miRanda -0.218861370922051 6.00579314883281e-11 NA NA NA hsa-miR-101-3p PPP3R1 -0.115297778040423 0.925564544736514 0.400656585765893 0.484071718240212 miRNATAP -0.187171459954337 1.17776284425277e-17 NA NA NA hsa-miR-181c-5p PPP3R1 0.287567602280886 0.587379107531716 0.400656585765893 0.484071718240212 MirTarget;miRNATAP -0.125950184238424 2.66954355100233e-14 NA NA NA hsa-miR-26a-5p PPP3R1 -0.0526989605494563 0.958167127738582 0.400656585765893 0.484071718240212 MirTarget;miRNATAP -0.15120972679612 1.94023722332139e-09 NA NA NA hsa-miR-30a-5p PPP3R1 -0.48552268915326 0.730142516403566 0.400656585765893 0.484071718240212 miRNAWalker2_validate;MirTarget;miRNATAP -0.13382780475557 1.01801426792285e-27 NA NA NA hsa-miR-141-3p PRICKLE1 0.518554136840043 0.543645265590794 0.633171373807942 0.146009408960389 TargetScan -0.110970210955193 3.06180806587071e-06 NA NA NA hsa-miR-30a-5p PRICKLE1 -0.48552268915326 0.730142516403566 0.633171373807942 0.146009408960389 miRNATAP -0.136509847501526 7.9340765409784e-07 NA NA NA hsa-miR-30b-5p PRICKLE1 0.1279779286756 0.872682355905147 0.633171373807942 0.146009408960389 mirMAP -0.181028075048876 1.82963092033562e-06 NA NA NA hsa-miR-30c-5p PRICKLE1 0.2904764284977 0.738803502565399 0.633171373807942 0.146009408960389 miRNATAP -0.185707414237874 1.02763767207438e-05 NA NA NA hsa-miR-30d-5p PRICKLE1 0.171445446354708 0.882863964947721 0.633171373807942 0.146009408960389 miRNATAP -0.25925039080586 1.16398766251352e-07 NA NA NA hsa-miR-338-3p PRICKLE1 -0.299081553502284 0.690790317255839 0.633171373807942 0.146009408960389 miRanda -0.272922631390263 3.10345977041188e-21 NA NA NA hsa-let-7a-3p PRICKLE2 0.311896921808493 0.499509698073189 -1.20320410751354 0.0117589308024567 mirMAP -0.246014128854383 2.22205350393919e-07 NA NA NA hsa-let-7f-1-3p PRICKLE2 0.541305090676599 0.000810726288280833 -1.20320410751354 0.0117589308024567 mirMAP -0.188710377572271 4.19141267701058e-07 NA NA NA hsa-miR-130b-5p PRICKLE2 1.3947936173305 4.50465898911354e-07 -1.20320410751354 0.0117589308024567 mirMAP -0.285840335314836 1.14671532560812e-24 NA NA NA hsa-miR-132-3p PRICKLE2 0.240816226207972 0.678532290124258 -1.20320410751354 0.0117589308024567 MirTarget;miRNATAP -0.13545645775625 0.00901118165664025 NA NA NA hsa-miR-146a-5p PRICKLE2 1.50457049554322 0.0123735084940492 -1.20320410751354 0.0117589308024567 mirMAP -0.22636521497307 1.32581685728342e-14 NA NA NA hsa-miR-148a-3p PRICKLE2 0.722527444447689 0.597269550476641 -1.20320410751354 0.0117589308024567 MirTarget;miRNATAP -0.136596669407525 0.000140359936538593 NA NA NA hsa-miR-148a-5p PRICKLE2 0.753389367124705 0.119008143405913 -1.20320410751354 0.0117589308024567 mirMAP -0.225124369392631 3.42801988361129e-10 NA NA NA hsa-miR-148b-3p PRICKLE2 0.139560003671114 0.825716083905455 -1.20320410751354 0.0117589308024567 MirTarget;miRNATAP -0.368462111806635 1.62423559573341e-16 NA NA NA hsa-miR-15b-3p PRICKLE2 1.33683404747498 0.00122709276757981 -1.20320410751354 0.0117589308024567 mirMAP -0.350402182346711 3.40989651980756e-35 NA NA NA hsa-miR-16-2-3p PRICKLE2 1.04875803256727 0.000133454779801128 -1.20320410751354 0.0117589308024567 mirMAP -0.331538116676408 5.09067457660196e-23 NA NA NA hsa-miR-181a-5p PRICKLE2 0.206424802853514 0.833057626260378 -1.20320410751354 0.0117589308024567 mirMAP;miRNATAP -0.249054061695165 2.07379976240012e-08 NA NA NA hsa-miR-181b-5p PRICKLE2 0.515446560070718 0.50566125221377 -1.20320410751354 0.0117589308024567 mirMAP;miRNATAP -0.32240643127462 3.08135600536136e-18 NA NA NA hsa-miR-181c-5p PRICKLE2 0.287567602280886 0.587379107531716 -1.20320410751354 0.0117589308024567 mirMAP;miRNATAP -0.169715036124902 9.09731846427341e-06 NA NA NA hsa-miR-182-5p PRICKLE2 -0.350218686073308 0.794131834526037 -1.20320410751354 0.0117589308024567 MirTarget -0.183980281487538 1.18712295456704e-09 NA NA NA hsa-miR-186-5p PRICKLE2 1.04333228080691 0.148711371364268 -1.20320410751354 0.0117589308024567 MirTarget -0.315192987077069 1.89815838419289e-12 NA NA NA hsa-miR-18a-5p PRICKLE2 2.29585803678176 4.13931899001596e-14 -1.20320410751354 0.0117589308024567 MirTarget -0.387730469036141 3.85619154280423e-61 NA NA NA hsa-miR-194-5p PRICKLE2 0.121400158256988 0.856838184584703 -1.20320410751354 0.0117589308024567 miRNATAP -0.291494776067705 3.80032824411756e-09 NA NA NA hsa-miR-197-3p PRICKLE2 1.20017939489121 0.103913584580121 -1.20320410751354 0.0117589308024567 mirMAP -0.259951469488209 8.6048620172375e-12 NA NA NA hsa-miR-19a-3p PRICKLE2 1.46790979235261 0.000361171910570302 -1.20320410751354 0.0117589308024567 MirTarget;miRNATAP -0.402369518872812 5.04349600060003e-48 NA NA NA hsa-miR-19b-3p PRICKLE2 1.16012277183793 0.0628519598637838 -1.20320410751354 0.0117589308024567 MirTarget;miRNATAP -0.400025342580155 8.2019109465105e-31 NA NA NA hsa-miR-21-5p PRICKLE2 -0.142759573450327 0.928848736959803 -1.20320410751354 0.0117589308024567 miRNAWalker2_validate;MirTarget -0.342742077988917 1.89622326605409e-18 NA NA NA hsa-miR-212-3p PRICKLE2 0.733470062196833 0.0007562475324171 -1.20320410751354 0.0117589308024567 MirTarget;miRNATAP -0.180712852119462 2.58202184300501e-07 NA NA NA hsa-miR-27a-3p PRICKLE2 0.628895559781173 0.490244908291708 -1.20320410751354 0.0117589308024567 MirTarget;miRNATAP -0.278229845269387 1.14515707500582e-08 NA NA NA hsa-miR-29b-3p PRICKLE2 0.271083597599281 0.740286663164405 -1.20320410751354 0.0117589308024567 MirTarget;miRNATAP -0.230464863795446 6.02712611151921e-09 NA NA NA hsa-miR-320b PRICKLE2 0.712468682578545 0.00260489977004221 -1.20320410751354 0.0117589308024567 mirMAP -0.227440830315089 3.84313880753253e-11 NA NA NA hsa-miR-330-3p PRICKLE2 0.537733996157442 0.00592119172883149 -1.20320410751354 0.0117589308024567 MirTarget -0.191111976333898 1.16789091807142e-07 NA NA NA hsa-miR-330-5p PRICKLE2 0.563423954500856 0.194785172695321 -1.20320410751354 0.0117589308024567 miRanda;miRNATAP -0.343203715809295 2.05881181519595e-17 NA NA NA hsa-miR-33a-5p PRICKLE2 1.35968072854277 1.76398171925026e-05 -1.20320410751354 0.0117589308024567 MirTarget -0.202816748660763 1.08415799126293e-20 NA NA NA hsa-miR-361-5p PRICKLE2 0.295581181703002 0.679805903809273 -1.20320410751354 0.0117589308024567 MirTarget;PITA;miRanda;miRNATAP -0.423190675531575 1.14669419541242e-08 NA NA NA hsa-miR-362-5p PRICKLE2 0.820801646347614 0.0107637300891325 -1.20320410751354 0.0117589308024567 mirMAP -0.277240440642943 4.36846092164439e-19 NA NA NA hsa-miR-374a-3p PRICKLE2 0.47806575213705 0.580820043553098 -1.20320410751354 0.0117589308024567 MirTarget;miRNATAP -0.294917743521684 5.68270721710634e-08 NA NA NA hsa-miR-429 PRICKLE2 0.448029985835258 0.437184735816941 -1.20320410751354 0.0117589308024567 miRNATAP -0.259740006651794 1.66095895526273e-28 NA NA NA hsa-miR-484 PRICKLE2 0.411127332258218 0.453891011654088 -1.20320410751354 0.0117589308024567 miRNATAP -0.21226644714009 8.08847112830986e-08 NA NA NA hsa-miR-500a-5p PRICKLE2 1.189064348723 1.51345772748382e-08 -1.20320410751354 0.0117589308024567 mirMAP -0.344234333311061 7.17467559930117e-27 NA NA NA hsa-miR-576-5p PRICKLE2 1.29396616748627 4.70941163094532e-05 -1.20320410751354 0.0117589308024567 mirMAP -0.318889040233355 6.40864949657442e-19 NA NA NA hsa-miR-589-3p PRICKLE2 0.869015836905941 1.30925035072401e-06 -1.20320410751354 0.0117589308024567 MirTarget -0.131279359595792 4.29454967061397e-06 NA NA NA hsa-miR-589-5p PRICKLE2 0.230201267274126 0.668365586561059 -1.20320410751354 0.0117589308024567 MirTarget;miRNATAP -0.410788762794066 5.39765560115147e-16 NA NA NA hsa-miR-590-3p PRICKLE2 1.01238246880436 6.25794947126089e-07 -1.20320410751354 0.0117589308024567 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.428246782039215 4.12749671901844e-37 NA NA NA hsa-miR-590-5p PRICKLE2 1.40236682288609 3.89322108176281e-06 -1.20320410751354 0.0117589308024567 MirTarget;PITA;miRanda -0.400059229125334 2.18643891880232e-35 NA NA NA hsa-miR-629-3p PRICKLE2 0.646784178673209 0.00160560935877895 -1.20320410751354 0.0117589308024567 MirTarget -0.17392475751545 7.91638698760279e-11 NA NA NA hsa-miR-7-1-3p PRICKLE2 -0.136535237676745 0.726879891153832 -1.20320410751354 0.0117589308024567 MirTarget -0.19024658377573 1.21829464745801e-08 NA NA NA hsa-miR-141-3p PRKACB 0.518554136840043 0.543645265590794 -0.258632386178568 0.620572444315033 MirTarget;TargetScan;miRNATAP -0.14986275424127 3.7367241254854e-07 NA NA NA hsa-miR-17-5p PRKACB 1.80801649919324 0.017740816345401 -0.258632386178568 0.620572444315033 TargetScan -0.167470485926017 1.11326049159611e-05 NA NA NA hsa-miR-18a-5p PRKACB 2.29585803678176 4.13931899001596e-14 -0.258632386178568 0.620572444315033 miRNATAP -0.109828861303179 0.000270889162356874 NA NA NA hsa-miR-19a-3p PRKACB 1.46790979235261 0.000361171910570302 -0.258632386178568 0.620572444315033 MirTarget;miRNATAP -0.144307019920445 3.41593280940585e-05 NA NA NA hsa-miR-19b-3p PRKACB 1.16012277183793 0.0628519598637838 -0.258632386178568 0.620572444315033 miRNAWalker2_validate;MirTarget;miRNATAP -0.13474256019019 0.00164169207970928 NA NA NA hsa-miR-200b-3p PRKACB 0.224286846990266 0.786394257540977 -0.258632386178568 0.620572444315033 MirTarget;TargetScan -0.128358992363134 6.97422500356901e-05 NA NA NA hsa-miR-200c-3p PRKACB 0.368794286773724 0.756435233803377 -0.258632386178568 0.620572444315033 MirTarget;miRNATAP -0.165596646495394 2.94921644943646e-06 NA NA NA hsa-miR-30d-3p PRKACB 0.267731984838241 0.27012774089276 -0.258632386178568 0.620572444315033 mirMAP -0.251818481172515 1.82407867076559e-06 NA NA NA hsa-miR-340-5p PRKACB 0.362079103949629 0.350652374274417 -0.258632386178568 0.620572444315033 mirMAP -0.151842813986032 0.001373090709035 NA NA NA hsa-miR-361-5p PRKACB 0.295581181703002 0.679805903809273 -0.258632386178568 0.620572444315033 miRanda -0.31917046064862 0.000326749716630808 NA NA NA hsa-miR-362-5p PRKACB 0.820801646347614 0.0107637300891325 -0.258632386178568 0.620572444315033 PITA -0.175108655019306 3.25359783331258e-06 NA NA NA hsa-miR-532-5p PRKACB 0.837154623550648 0.324129802476266 -0.258632386178568 0.620572444315033 PITA -0.167904290632964 0.00255889279358267 NA NA NA hsa-miR-93-5p PRKACB 0.943892623097563 0.3984984603332 -0.258632386178568 0.620572444315033 miRNAWalker2_validate -0.337877597223658 9.95580809015501e-13 NA NA NA hsa-miR-181b-5p PRKCA 0.515446560070718 0.50566125221377 1.08545977988408 0.000986469275480055 mirMAP -0.11742885805708 0.0062191009662321 NA NA NA hsa-miR-181c-5p PRKCA 0.287567602280886 0.587379107531716 1.08545977988408 0.000986469275480055 mirMAP -0.151937361609795 0.00048559417186175 NA NA NA hsa-miR-183-5p PRKCA 0.204550384370393 0.863354421890003 1.08545977988408 0.000986469275480055 miRNATAP -0.382401275003301 4.39521361355191e-39 NA NA NA hsa-miR-193b-3p PRKCA -0.1716399255813 0.776242454007098 1.08545977988408 0.000986469275480055 miRNAWalker2_validate -0.158591304154604 9.61914010087921e-05 NA NA NA hsa-miR-194-5p PRKCA 0.121400158256988 0.856838184584703 1.08545977988408 0.000986469275480055 mirMAP -0.194734764385864 0.000579018161354159 NA NA NA hsa-miR-200b-3p PRKCA 0.224286846990266 0.786394257540977 1.08545977988408 0.000986469275480055 TargetScan -0.338107140907763 7.43601898887161e-30 NA NA NA hsa-miR-200c-3p PRKCA 0.368794286773724 0.756435233803377 1.08545977988408 0.000986469275480055 miRNATAP -0.384868851727468 4.79014422420278e-32 NA NA NA hsa-miR-29b-2-5p PRKCA -1.15291700929952 0.0234666802434694 1.08545977988408 0.000986469275480055 mirMAP -0.365220324605892 6.60788568306249e-22 NA NA NA hsa-miR-30d-3p PRKCA 0.267731984838241 0.27012774089276 1.08545977988408 0.000986469275480055 mirMAP -0.185045137833304 0.000246654172160224 NA NA NA hsa-miR-339-5p PRKCA 0.176562373115907 0.71435382230926 1.08545977988408 0.000986469275480055 mirMAP -0.116903398908303 0.00661066095178211 NA NA NA hsa-miR-340-5p PRKCA 0.362079103949629 0.350652374274417 1.08545977988408 0.000986469275480055 mirMAP -0.157880969288124 0.000482930053726641 NA NA NA hsa-miR-375 PRKCA -2.04856771988218 0.0875384684997331 1.08545977988408 0.000986469275480055 miRNAWalker2_validate -0.240131861837491 2.29799527522168e-39 NA NA NA hsa-miR-429 PRKCA 0.448029985835258 0.437184735816941 1.08545977988408 0.000986469275480055 miRanda;miRNATAP -0.302006017947741 7.14515269636082e-30 NA NA NA hsa-miR-141-5p PRKCB 0.148357564860886 0.854593186542924 0.737584286284365 0.0171817937331764 mirMAP -0.127187131565152 0.00154757873879663 NA NA NA hsa-miR-200b-3p PRKCB 0.224286846990266 0.786394257540977 0.737584286284365 0.0171817937331764 MirTarget -0.185811618752792 2.61023291805883e-06 NA NA NA hsa-miR-200c-3p PRKCB 0.368794286773724 0.756435233803377 0.737584286284365 0.0171817937331764 MirTarget;miRNATAP -0.190171510726694 1.24294313881003e-05 NA NA NA hsa-miR-29b-2-5p PRKCB -1.15291700929952 0.0234666802434694 0.737584286284365 0.0171817937331764 mirMAP -0.248738713275143 5.96583916655133e-07 NA NA NA hsa-miR-30b-5p PRKCB 0.1279779286756 0.872682355905147 0.737584286284365 0.0171817937331764 mirMAP -0.181899501701348 0.00172429854651836 NA NA NA hsa-miR-30c-5p PRKCB 0.2904764284977 0.738803502565399 0.737584286284365 0.0171817937331764 mirMAP -0.266676621567604 3.26692465594906e-05 NA NA NA hsa-miR-30d-3p PRKCB 0.267731984838241 0.27012774089276 0.737584286284365 0.0171817937331764 mirMAP -0.176195796338334 0.00676988213351706 NA NA NA hsa-miR-338-3p PRKCB -0.299081553502284 0.690790317255839 0.737584286284365 0.0171817937331764 miRanda -0.216031823790678 1.44429456470486e-06 NA NA NA hsa-miR-429 PRKCB 0.448029985835258 0.437184735816941 0.737584286284365 0.0171817937331764 MirTarget;miRanda;miRNATAP -0.177108211107202 5.14864677602474e-07 NA NA NA hsa-miR-664a-3p PRKCB -0.254427346780448 0.599878061586463 0.737584286284365 0.0171817937331764 mirMAP -0.30918523276408 8.70938453871888e-07 NA NA NA hsa-miR-182-5p PRKX -0.350218686073308 0.794131834526037 1.91740115243831 2.73254159111166e-05 mirMAP -0.175194994974604 2.67502751484288e-08 NA NA NA hsa-miR-29b-3p PRKX 0.271083597599281 0.740286663164405 1.91740115243831 2.73254159111166e-05 mirMAP -0.120330213613139 0.0037387071410825 NA NA NA hsa-miR-29c-3p PRKX -0.643278710106618 0.522845109493165 1.91740115243831 2.73254159111166e-05 mirMAP -0.38827959473025 7.47361121556913e-23 NA NA NA hsa-miR-375 PRKX -2.04856771988218 0.0875384684997331 1.91740115243831 2.73254159111166e-05 miRNAWalker2_validate;miRanda -0.207392873270567 7.07421795114455e-35 NA NA NA hsa-miR-625-3p PRKX -0.289986410760694 0.681740445182542 1.91740115243831 2.73254159111166e-05 mirMAP -0.146145038207053 0.00114969241015916 NA NA NA hsa-miR-361-5p PSEN1 0.295581181703002 0.679805903809273 -0.289540947120726 0.627239470934635 miRanda -0.201624103764595 1.00858341777568e-11 NA NA NA hsa-miR-101-3p RAC1 -0.115297778040423 0.925564544736514 -0.00381220632573864 0.995951093383478 miRNAWalker2_validate;MirTarget -0.139972978942608 1.93650351223228e-14 25202416;24649082;25057058 In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR cell migration;; thyroid cancer;thyroid cancer;colorectal cancer hsa-miR-193b-3p RAC2 -0.1716399255813 0.776242454007098 0.376180943205868 0.433777943243028 miRNAWalker2_validate -0.163439972898065 2.05534635731132e-06 NA NA NA hsa-miR-491-5p RAC2 -0.0426464166135634 0.817052196076797 0.376180943205868 0.433777943243028 miRanda -0.170510866222564 9.84222871672058e-08 NA NA NA hsa-miR-125a-5p RAC3 -0.142178978822393 0.87178508980574 -0.0797054370858477 0.839587660500352 PITA -0.214154670070607 8.31103753734932e-06 NA NA NA hsa-miR-139-5p RBX1 -0.292245043386175 0.603867611856128 0.254976311539798 0.624111383196381 miRanda -0.138659130309957 7.99349725093936e-22 NA NA NA hsa-miR-107 ROCK1 0.351433472692356 0.523819413335979 0.00044110360580607 0.999360499396365 miRanda -0.214652817656713 7.4445514442289e-10 NA NA NA hsa-miR-429 ROCK1 0.448029985835258 0.437184735816941 0.00044110360580607 0.999360499396365 miRanda -0.107368538530982 2.74283719948915e-11 NA NA NA hsa-miR-200b-3p ROCK2 0.224286846990266 0.786394257540977 0.377201812755962 0.433848507428904 TargetScan -0.238045362418837 5.70621727270586e-16 NA NA NA hsa-miR-340-5p ROCK2 0.362079103949629 0.350652374274417 0.377201812755962 0.433848507428904 mirMAP -0.395127263389571 3.35868529258436e-20 NA NA NA hsa-miR-429 ROCK2 0.448029985835258 0.437184735816941 0.377201812755962 0.433848507428904 PITA;miRanda;miRNATAP -0.205818358236693 4.93110698663187e-15 NA NA NA hsa-miR-140-5p RUVBL1 0.781948085004431 0.101152958138705 0.287335054656966 0.587907051593215 miRanda -0.115192679042016 8.12213333695103e-06 NA NA NA hsa-miR-34c-5p RUVBL1 -0.737055618983188 0.0183539797898893 0.287335054656966 0.587907051593215 miRanda -0.100087979601338 8.64529686751099e-09 NA NA NA hsa-miR-140-3p SENP2 0.562212100226517 0.538115971474499 -0.0380255511443837 0.937390399871253 mirMAP -0.111140304488665 5.70505657181129e-11 NA NA NA hsa-miR-369-3p SENP2 -0.147594099352296 0.572262502832966 -0.0380255511443837 0.937390399871253 mirMAP -0.111437274643639 3.8132936287651e-14 NA NA NA hsa-miR-1301-3p SFRP1 1.13236779080729 0.00035660210335027 3.81079089449119 6.71783240746346e-08 MirTarget -0.627568666111828 8.02299635565225e-16 NA NA NA hsa-miR-16-1-3p SFRP1 0.416431607020454 0.0443663162632403 3.81079089449119 6.71783240746346e-08 MirTarget -0.711103027959144 8.81693153322732e-12 NA NA NA hsa-miR-182-5p SFRP1 -0.350218686073308 0.794131834526037 3.81079089449119 6.71783240746346e-08 mirMAP -0.967266087949178 4.26592739938163e-34 NA NA NA hsa-miR-429 SFRP1 0.448029985835258 0.437184735816941 3.81079089449119 6.71783240746346e-08 miRNATAP -0.482539995817486 1.02848505471575e-13 NA NA NA hsa-miR-484 SFRP1 0.411127332258218 0.453891011654088 3.81079089449119 6.71783240746346e-08 MirTarget -0.736652971526416 5.14194951874832e-12 NA NA NA hsa-miR-625-5p SFRP1 -0.12821717169837 0.460013404839361 3.81079089449119 6.71783240746346e-08 MirTarget -0.628996046116407 2.3830320131247e-12 NA NA NA hsa-miR-7-1-3p SFRP1 -0.136535237676745 0.726879891153832 3.81079089449119 6.71783240746346e-08 MirTarget;mirMAP -0.630150561051086 2.75485010272039e-12 NA NA NA hsa-miR-96-5p SFRP1 0.100415780625178 0.816616062681011 3.81079089449119 6.71783240746346e-08 mirMAP -0.844516363711542 6.21667681893678e-38 NA NA NA hsa-let-7a-3p SFRP2 0.311896921808493 0.499509698073189 -1.01636328892149 0.19917107559761 miRNATAP -0.332636167789599 4.93713573566124e-06 NA NA NA hsa-miR-455-5p SFRP2 1.38138264178539 0.00151082519157593 -1.01636328892149 0.19917107559761 miRanda -0.2181929694718 1.02630459230339e-05 NA NA NA hsa-miR-590-3p SFRP2 1.01238246880436 6.25794947126089e-07 -1.01636328892149 0.19917107559761 miRanda -0.307596222223987 8.75286794331675e-09 NA NA NA hsa-miR-3607-3p SFRP4 -0.0336542423413588 0.943687112266464 -0.93634333242009 0.129671801922697 MirTarget -0.118981576120521 0.000643377135339091 NA NA NA hsa-miR-429 SFRP4 0.448029985835258 0.437184735816941 -0.93634333242009 0.129671801922697 miRanda -0.313049201490686 1.13859376562001e-16 NA NA NA hsa-miR-532-5p SFRP4 0.837154623550648 0.324129802476266 -0.93634333242009 0.129671801922697 MirTarget -0.348327615827745 2.35831438297707e-06 NA NA NA hsa-miR-15a-5p SIAH1 0.342480184869245 0.605040217513538 0.105265635932638 0.810218017225784 miRNATAP -0.119160033954367 1.42207849374965e-07 NA NA NA hsa-miR-130a-3p SKP1 0.849038376258018 0.133664106340641 -0.762879020249815 0.30873051897607 MirTarget -0.139641825685064 4.17514374271046e-19 NA NA NA hsa-miR-130b-3p SKP1 1.16970507422762 6.85086072809354e-05 -0.762879020249815 0.30873051897607 MirTarget -0.106102178127117 1.72601795720608e-11 NA NA NA hsa-miR-222-3p SKP1 1.01165425875596 0.0347025183740878 -0.762879020249815 0.30873051897607 MirTarget -0.10501825880122 4.51166430229641e-11 NA NA NA hsa-miR-181a-5p SMAD2 0.206424802853514 0.833057626260378 0.0896417380696963 0.879749050042635 mirMAP -0.115122429788219 8.47012412856965e-11 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 0.515446560070718 0.50566125221377 0.0896417380696963 0.879749050042635 mirMAP -0.112879931507918 3.62142519922135e-14 NA NA NA hsa-miR-340-5p SMAD2 0.362079103949629 0.350652374274417 0.0896417380696963 0.879749050042635 MirTarget -0.145840275032375 8.51041709723394e-21 NA NA NA hsa-miR-361-3p SMAD2 0.35229279501788 0.603486581638137 0.0896417380696963 0.879749050042635 miRNATAP -0.128521633108847 3.38235989722682e-08 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-miR-361-5p SMAD2 0.295581181703002 0.679805903809273 0.0896417380696963 0.879749050042635 MirTarget -0.168440579811925 1.40285064429544e-08 NA NA NA hsa-miR-542-3p SMAD2 0.0492894440657814 0.946714392793758 0.0896417380696963 0.879749050042635 PITA -0.104251622984305 3.31535587210055e-12 NA NA NA hsa-miR-155-5p SMAD3 1.12529442422533 0.131933535981501 -0.634620777185637 0.245352362300656 miRNAWalker2_validate -0.161248941325708 6.88088611744894e-17 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-15a-5p SMAD3 0.342480184869245 0.605040217513538 -0.634620777185637 0.245352362300656 MirTarget -0.127238885845652 3.99211956272264e-05 NA NA NA hsa-miR-15b-5p SMAD3 0.687228605707872 0.304427884697749 -0.634620777185637 0.245352362300656 MirTarget -0.103829420518863 1.25324379645245e-05 NA NA NA hsa-miR-17-5p SMAD3 1.80801649919324 0.017740816345401 -0.634620777185637 0.245352362300656 miRNAWalker2_validate -0.144062907194855 1.0396353881575e-12 NA NA NA hsa-miR-185-5p SMAD3 0.413180953895098 0.435464963453554 -0.634620777185637 0.245352362300656 MirTarget -0.139641114876277 4.17733017511663e-05 NA NA NA hsa-miR-18a-5p SMAD3 2.29585803678176 4.13931899001596e-14 -0.634620777185637 0.245352362300656 miRNAWalker2_validate -0.145191271950291 4.28063578565896e-20 23249750 The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling glioblastoma hsa-miR-1976 SMAD3 0.478085481683187 0.0981551338070376 -0.634620777185637 0.245352362300656 MirTarget -0.121630671332983 6.52049342337766e-05 NA NA NA hsa-miR-28-5p SMAD3 0.698472090600538 0.237744307568605 -0.634620777185637 0.245352362300656 miRNATAP -0.120097254990824 0.00200641803458376 NA NA NA hsa-miR-330-5p SMAD3 0.563423954500856 0.194785172695321 -0.634620777185637 0.245352362300656 miRanda -0.106180722787539 5.07248451793749e-05 NA NA NA hsa-miR-429 SMAD3 0.448029985835258 0.437184735816941 -0.634620777185637 0.245352362300656 miRNATAP -0.102063359852527 2.55000912428033e-11 NA NA NA hsa-miR-590-3p SMAD3 1.01238246880436 6.25794947126089e-07 -0.634620777185637 0.245352362300656 miRanda -0.163099760014662 1.73477690677951e-13 NA NA NA hsa-miR-671-5p SMAD3 0.834434167250404 7.38955042149834e-05 -0.634620777185637 0.245352362300656 MirTarget -0.132445297015047 2.33568059728177e-10 NA NA NA hsa-miR-769-5p SMAD3 0.512116522144434 0.186450175665294 -0.634620777185637 0.245352362300656 miRNATAP -0.121091427985316 6.14487597806327e-05 NA NA NA hsa-miR-106b-5p SMAD4 1.04856358809711 0.139094273282727 0.00246927764713956 0.996553736715913 mirMAP;miRNATAP -0.132593131707842 2.60050027244317e-11 NA NA NA hsa-miR-146b-5p SMAD4 0.876334790841257 0.284935762703604 0.00246927764713956 0.996553736715913 PITA;miRanda;miRNATAP -0.13881112685924 1.84558785229961e-14 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-155-5p SMAD4 1.12529442422533 0.131933535981501 0.00246927764713956 0.996553736715913 miRNAWalker2_validate -0.114314883374695 1.83733755300191e-14 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-21-3p SMAD4 0.115900341574742 0.904443786801208 0.00246927764713956 0.996553736715913 mirMAP -0.142251679213528 1.79438322002583e-18 NA NA NA hsa-miR-27a-3p SMAD4 0.628895559781173 0.490244908291708 0.00246927764713956 0.996553736715913 MirTarget -0.107318887613883 7.95509636261065e-06 NA NA NA hsa-miR-32-5p SMAD4 0.531860098119996 0.195500436097555 0.00246927764713956 0.996553736715913 mirMAP -0.104053876543456 9.38449586813502e-09 NA NA NA hsa-miR-361-5p SMAD4 0.295581181703002 0.679805903809273 0.00246927764713956 0.996553736715913 mirMAP -0.13420862344236 0.000247319809078657 NA NA NA hsa-miR-589-5p SMAD4 0.230201267274126 0.668365586561059 0.00246927764713956 0.996553736715913 miRNATAP -0.184456440754787 1.53364140974385e-13 NA NA NA hsa-miR-93-5p SMAD4 0.943892623097563 0.3984984603332 0.00246927764713956 0.996553736715913 miRNAWalker2_validate;mirMAP;miRNATAP -0.118636275861089 1.4710971943885e-09 NA NA NA hsa-miR-141-3p SOX17 0.518554136840043 0.543645265590794 -0.560525779482175 0.0308240186992835 TargetScan -0.426856956954328 5.06746881736312e-61 22921431 Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer; MicroRNA 141 was also found to down-regulate SOX17 expression and activate the WNT signal pathway esophageal cancer hsa-miR-330-5p SOX17 0.563423954500856 0.194785172695321 -0.560525779482175 0.0308240186992835 miRanda -0.461434964169255 9.94438298481541e-25 NA NA NA hsa-miR-590-3p SOX17 1.01238246880436 6.25794947126089e-07 -0.560525779482175 0.0308240186992835 miRanda;miRNATAP -0.437832269833539 1.45583399447421e-30 NA NA NA hsa-miR-590-5p SOX17 1.40236682288609 3.89322108176281e-06 -0.560525779482175 0.0308240186992835 miRanda -0.386693548488825 4.68900931678905e-26 NA NA NA hsa-miR-22-5p TBL1X 0.386811466292275 0.351646252133174 -0.0681426392067168 0.896599190247756 mirMAP -0.113674770615703 1.28737390658952e-05 NA NA NA hsa-miR-140-3p TBL1XR1 0.562212100226517 0.538115971474499 -0.00436001115619966 0.994775281780602 PITA -0.222142997474086 4.16347181412021e-26 NA NA NA hsa-miR-542-3p TBL1XR1 0.0492894440657814 0.946714392793758 -0.00436001115619966 0.994775281780602 MirTarget;PITA;miRanda -0.113018558915214 2.3915716506794e-08 NA NA NA hsa-miR-889-3p TBL1XR1 -0.17134710821136 0.641837663634902 -0.00436001115619966 0.994775281780602 MirTarget -0.136425907469045 3.79884694261387e-15 NA NA NA hsa-miR-331-3p TCF7 0.259002302197189 0.507018043618617 0.755896629310549 0.0621219384142161 MirTarget;miRNATAP -0.153308578278305 7.71083941170175e-06 NA NA NA hsa-miR-141-3p TCF7L1 0.518554136840043 0.543645265590794 1.91755687706501 8.76243995756295e-05 miRNAWalker2_validate -0.199972471420516 6.28430074006789e-11 NA NA NA hsa-miR-200a-3p TCF7L1 0.298946102269216 0.671358593831 1.91755687706501 8.76243995756295e-05 miRNAWalker2_validate -0.150558299078396 6.03400969336786e-07 NA NA NA hsa-miR-200b-3p TCF7L1 0.224286846990266 0.786394257540977 1.91755687706501 8.76243995756295e-05 miRNAWalker2_validate -0.168143697293025 5.41553060367198e-07 NA NA NA hsa-miR-200c-3p TCF7L1 0.368794286773724 0.756435233803377 1.91755687706501 8.76243995756295e-05 miRNAWalker2_validate -0.229533628135833 4.20710186780113e-10 NA NA NA hsa-miR-429 TCF7L1 0.448029985835258 0.437184735816941 1.91755687706501 8.76243995756295e-05 miRNAWalker2_validate -0.134496234177534 7.39492362051745e-06 NA NA NA hsa-miR-107 TCF7L2 0.351433472692356 0.523819413335979 0.811247817411131 0.0903116083585558 miRanda -0.247661729975441 3.82905437520373e-08 NA NA NA hsa-miR-148b-3p TCF7L2 0.139560003671114 0.825716083905455 0.811247817411131 0.0903116083585558 miRNAWalker2_validate -0.36003166883339 8.1210275031183e-21 NA NA NA hsa-miR-15b-3p TCF7L2 1.33683404747498 0.00122709276757981 0.811247817411131 0.0903116083585558 miRNATAP -0.105562680055541 3.49079711601082e-05 NA NA NA hsa-miR-182-5p TCF7L2 -0.350218686073308 0.794131834526037 0.811247817411131 0.0903116083585558 miRNATAP -0.285458372953323 5.15013518210834e-29 NA NA NA hsa-miR-183-5p TCF7L2 0.204550384370393 0.863354421890003 0.811247817411131 0.0903116083585558 MirTarget;miRNATAP -0.256342247617245 6.25752369970953e-30 NA NA NA hsa-miR-193a-3p TCF7L2 0.183521555169311 0.61877899263343 0.811247817411131 0.0903116083585558 miRanda -0.13669345972878 7.45997149176231e-05 NA NA NA hsa-miR-338-3p TCF7L2 -0.299081553502284 0.690790317255839 0.811247817411131 0.0903116083585558 miRanda -0.164700048645429 4.65832433017924e-10 NA NA NA hsa-miR-342-3p TCF7L2 -0.720941204737844 0.328091715069398 0.811247817411131 0.0903116083585558 miRanda -0.233358442684096 1.49785192802606e-18 NA NA NA hsa-miR-429 TCF7L2 0.448029985835258 0.437184735816941 0.811247817411131 0.0903116083585558 miRNATAP -0.171121027184894 1.09303298527548e-16 NA NA NA hsa-miR-590-3p TCF7L2 1.01238246880436 6.25794947126089e-07 0.811247817411131 0.0903116083585558 miRanda -0.121584977112315 6.35614091956812e-05 NA NA NA hsa-miR-625-5p TCF7L2 -0.12821717169837 0.460013404839361 0.811247817411131 0.0903116083585558 MirTarget -0.196349842308205 7.37475139500119e-12 NA NA NA hsa-miR-96-5p TCF7L2 0.100415780625178 0.816616062681011 0.811247817411131 0.0903116083585558 MirTarget;TargetScan;miRNATAP -0.237827941772781 2.94405056699388e-29 NA NA NA hsa-miR-99b-3p TCF7L2 0.463888153019217 0.392933603868287 0.811247817411131 0.0903116083585558 MirTarget;miRNATAP -0.144432671942689 4.79981484254922e-05 NA NA NA hsa-miR-130a-3p VANGL1 0.849038376258018 0.133664106340641 0.090913351384871 0.851935336497162 mirMAP -0.13320016720032 5.81451951775816e-10 NA NA NA hsa-miR-139-5p VANGL1 -0.292245043386175 0.603867611856128 0.090913351384871 0.851935336497162 miRanda -0.161777639176173 6.00227916383558e-22 NA NA NA hsa-miR-195-5p VANGL1 -0.130193686630835 0.80220061875718 0.090913351384871 0.851935336497162 mirMAP -0.234198291882211 1.61785278026182e-23 NA NA NA hsa-miR-214-3p VANGL1 -0.325381001148475 0.257166731470048 0.090913351384871 0.851935336497162 mirMAP -0.137565470387465 8.31314037723104e-12 NA NA NA hsa-miR-218-5p VANGL1 0.00601807710560021 0.990534925701382 0.090913351384871 0.851935336497162 mirMAP -0.227997550601069 9.78752605670574e-18 NA NA NA hsa-miR-26a-5p VANGL1 -0.0526989605494563 0.958167127738582 0.090913351384871 0.851935336497162 mirMAP -0.376690599739968 1.73365456652659e-24 NA NA NA hsa-miR-320a VANGL1 0.241225090812918 0.773692094298861 0.090913351384871 0.851935336497162 mirMAP -0.136314967525611 1.82491693402936e-05 NA NA NA hsa-miR-378c VANGL1 1.08814722613606 4.20223477377423e-05 0.090913351384871 0.851935336497162 miRNATAP -0.13496008439357 3.32243434568058e-11 NA NA NA hsa-miR-485-3p VANGL1 0.0755008543866269 0.751124972921196 0.090913351384871 0.851935336497162 mirMAP -0.112215433433973 2.23086646351406e-07 NA NA NA hsa-miR-7-1-3p VANGL2 -0.136535237676745 0.726879891153832 1.45702876625664 0.00478800183630957 mirMAP -0.142492068299119 0.00779650628148012 NA NA NA hsa-miR-107 WIF1 0.351433472692356 0.523819413335979 2.05165480467634 2.76919327749875e-05 miRanda -0.805243011250718 6.66023850485786e-06 NA NA NA hsa-miR-330-5p WIF1 0.563423954500856 0.194785172695321 2.05165480467634 2.76919327749875e-05 miRanda -0.660990097984299 2.58056748637709e-06 NA NA NA hsa-miR-342-3p WIF1 -0.720941204737844 0.328091715069398 2.05165480467634 2.76919327749875e-05 miRanda -0.900150959597263 1.15455195350394e-17 NA NA NA hsa-miR-429 WIF1 0.448029985835258 0.437184735816941 2.05165480467634 2.76919327749875e-05 miRanda -0.57801116079909 1.92906319858818e-12 NA NA NA hsa-miR-590-3p WIF1 1.01238246880436 6.25794947126089e-07 2.05165480467634 2.76919327749875e-05 PITA;miRanda;mirMAP -0.639334008119333 9.64663705878253e-08 NA NA NA hsa-miR-664a-3p WNT10A -0.254427346780448 0.599878061586463 2.09356067552938 1.34132402888639e-18 mirMAP -0.421214281367344 2.22889192706043e-09 NA NA NA hsa-miR-148a-3p WNT10B 0.722527444447689 0.597269550476641 0.47939642570591 0.0283127307195823 MirTarget -0.225697074269929 2.08337307308921e-05 NA NA NA hsa-miR-148b-3p WNT10B 0.139560003671114 0.825716083905455 0.47939642570591 0.0283127307195823 MirTarget -0.328579720045847 9.29413365918993e-07 NA NA NA hsa-miR-342-3p WNT10B -0.720941204737844 0.328091715069398 0.47939642570591 0.0283127307195823 miRanda -0.184377326541959 6.55689831892104e-05 NA NA NA hsa-miR-429 WNT11 0.448029985835258 0.437184735816941 0.675595082125289 0.0377005053812776 miRNATAP -0.283953214425953 3.59806376562941e-10 NA NA NA hsa-miR-590-3p WNT11 1.01238246880436 6.25794947126089e-07 0.675595082125289 0.0377005053812776 miRanda -0.293944853552164 8.66172138800842e-06 NA NA NA hsa-miR-139-5p WNT2 -0.292245043386175 0.603867611856128 0.223760110893537 0.469618111201829 miRanda -0.250813000106968 6.69310140321002e-11 NA NA NA hsa-miR-335-3p WNT2 0.20540439554909 0.735174242671502 0.223760110893537 0.469618111201829 mirMAP -0.124921231734074 0.0013759064532322 NA NA NA hsa-miR-361-3p WNT2 0.35229279501788 0.603486581638137 0.223760110893537 0.469618111201829 MirTarget -0.266339316841169 0.00199408748413513 NA NA NA hsa-miR-130b-3p WNT2B 1.16970507422762 6.85086072809354e-05 0.147739988992831 0.364880733845567 MirTarget -0.16709837520953 1.43976112122382e-06 NA NA NA hsa-miR-301a-3p WNT2B 0.968506401137921 0.000570564850124159 0.147739988992831 0.364880733845567 MirTarget -0.104564831857354 0.000130211401798741 NA NA NA hsa-miR-429 WNT2B 0.448029985835258 0.437184735816941 0.147739988992831 0.364880733845567 miRNATAP -0.137551404474967 5.5132158702989e-08 NA NA NA hsa-miR-454-3p WNT2B 0.427403467632791 0.11673336658399 0.147739988992831 0.364880733845567 MirTarget -0.174716398885358 1.14167579103774e-07 NA NA NA hsa-miR-146a-5p WNT3 1.50457049554322 0.0123735084940492 -0.240302124351824 0.215821203926234 MirTarget -0.201603839063412 1.26011961583069e-07 NA NA NA hsa-miR-146b-5p WNT3 0.876334790841257 0.284935762703604 -0.240302124351824 0.215821203926234 MirTarget;PITA;miRanda;miRNATAP -0.19864051897856 3.55693736099291e-05 NA NA NA hsa-miR-214-3p WNT3 -0.325381001148475 0.257166731470048 -0.240302124351824 0.215821203926234 MirTarget -0.217458243957451 4.77314673966333e-08 NA NA NA hsa-miR-215-5p WNT3 0.469167912455808 0.0652445033370017 -0.240302124351824 0.215821203926234 miRNAWalker2_validate -0.202617944190342 6.29886106348422e-08 NA NA NA hsa-miR-374a-3p WNT3 0.47806575213705 0.580820043553098 -0.240302124351824 0.215821203926234 MirTarget -0.289753487107474 3.61014430173007e-05 NA NA NA hsa-miR-374a-5p WNT3 0.47302975636239 0.309552532909276 -0.240302124351824 0.215821203926234 MirTarget -0.450647176110379 8.40472532505734e-11 NA NA NA hsa-miR-374b-5p WNT3 0.478896841162915 0.365769179152496 -0.240302124351824 0.215821203926234 MirTarget -0.339662315482385 7.32586953128491e-07 NA NA NA hsa-miR-376c-3p WNT3 0.177287323663752 0.476545120556045 -0.240302124351824 0.215821203926234 MirTarget -0.209776014145028 2.6988219390376e-08 NA NA NA hsa-miR-576-5p WNT3 1.29396616748627 4.70941163094532e-05 -0.240302124351824 0.215821203926234 mirMAP -0.138865149881875 0.0032152515286964 NA NA NA hsa-miR-589-3p WNT3 0.869015836905941 1.30925035072401e-06 -0.240302124351824 0.215821203926234 mirMAP -0.105204288945704 0.00433518385741643 NA NA NA hsa-miR-16-5p WNT3A 0.608716035131087 0.441059798918702 0.00923247637726909 0.982458472243033 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.223562434556754 0.00686252591255575 NA NA NA hsa-miR-331-3p WNT3A 0.259002302197189 0.507018043618617 0.00923247637726909 0.982458472243033 mirMAP -0.186748490696253 0.00116808678187749 NA NA NA hsa-miR-335-5p WNT3A 0.0404259244994374 0.914858946651589 0.00923247637726909 0.982458472243033 mirMAP -0.144104496367168 0.00107984254818266 NA NA NA hsa-let-7a-3p WNT5A 0.311896921808493 0.499509698073189 -0.489836165906155 0.238638304352526 miRNATAP -0.22117753231769 0.000441970481202632 NA NA NA hsa-miR-141-3p WNT5A 0.518554136840043 0.543645265590794 -0.489836165906155 0.238638304352526 TargetScan -0.139214845204003 2.12785375749739e-05 NA NA NA hsa-miR-144-5p WNT5A 0.193779998748036 0.72991328591606 -0.489836165906155 0.238638304352526 mirMAP -0.108189974261664 0.000232182868580216 NA NA NA hsa-miR-15b-3p WNT5A 1.33683404747498 0.00122709276757981 -0.489836165906155 0.238638304352526 mirMAP -0.282465371884018 2.03011972026487e-13 NA NA NA hsa-miR-16-2-3p WNT5A 1.04875803256727 0.000133454779801128 -0.489836165906155 0.238638304352526 MirTarget;mirMAP -0.339885804294178 3.30301649240528e-14 NA NA NA hsa-miR-16-5p WNT5A 0.608716035131087 0.441059798918702 -0.489836165906155 0.238638304352526 miRNAWalker2_validate -0.443371863255678 2.01154967356747e-14 NA NA NA hsa-miR-186-5p WNT5A 1.04333228080691 0.148711371364268 -0.489836165906155 0.238638304352526 miRNAWalker2_validate;mirMAP;miRNATAP -0.302944959464288 3.52342706593741e-07 NA NA NA hsa-miR-29a-5p WNT5A 0.800121562512528 0.00103825219976412 -0.489836165906155 0.238638304352526 mirMAP -0.173390051712273 0.000449511750498096 NA NA NA hsa-miR-30b-5p WNT5A 0.1279779286756 0.872682355905147 -0.489836165906155 0.238638304352526 mirMAP -0.221268990849156 2.30222342732902e-05 NA NA NA hsa-miR-30c-5p WNT5A 0.2904764284977 0.738803502565399 -0.489836165906155 0.238638304352526 mirMAP -0.153444255475845 0.00829557687465555 NA NA NA hsa-miR-30d-3p WNT5A 0.267731984838241 0.27012774089276 -0.489836165906155 0.238638304352526 mirMAP -0.328486161205366 1.77036516167105e-08 NA NA NA hsa-miR-30d-5p WNT5A 0.171445446354708 0.882863964947721 -0.489836165906155 0.238638304352526 mirMAP -0.395918928140374 3.76530346593888e-09 NA NA NA hsa-miR-30e-5p WNT5A 0.74013844669909 0.511970582859704 -0.489836165906155 0.238638304352526 mirMAP -0.355937424695316 3.98104999357833e-07 NA NA NA hsa-miR-330-5p WNT5A 0.563423954500856 0.194785172695321 -0.489836165906155 0.238638304352526 miRanda -0.254694138871707 2.53849290717674e-06 NA NA NA hsa-miR-340-5p WNT5A 0.362079103949629 0.350652374274417 -0.489836165906155 0.238638304352526 miRNATAP -0.151352324882194 0.00401003633166406 NA NA NA hsa-miR-374b-5p WNT5A 0.478896841162915 0.365769179152496 -0.489836165906155 0.238638304352526 MirTarget;miRNATAP -0.20398183143879 0.00391173355873326 NA NA NA hsa-miR-576-5p WNT5A 1.29396616748627 4.70941163094532e-05 -0.489836165906155 0.238638304352526 mirMAP -0.219900857430154 5.01514505641987e-06 NA NA NA hsa-miR-590-3p WNT5A 1.01238246880436 6.25794947126089e-07 -0.489836165906155 0.238638304352526 miRanda;mirMAP;miRNATAP -0.276206250056969 2.00878373474974e-09 NA NA NA hsa-miR-7-1-3p WNT5A -0.136535237676745 0.726879891153832 -0.489836165906155 0.238638304352526 mirMAP -0.228321533184529 2.31205663077237e-07 NA NA NA hsa-miR-92a-3p WNT5A 1.22719477478376 0.303128344063904 -0.489836165906155 0.238638304352526 miRNAWalker2_validate -0.456191278985706 5.11502285589708e-16 NA NA NA hsa-miR-339-5p WNT5B 0.176562373115907 0.71435382230926 0.362377115638296 0.218165204134243 miRanda -0.185095344713092 5.01294231609421e-05 NA NA NA hsa-miR-10b-5p WNT7B -0.802647383158369 0.589117522662311 -0.955718862585083 0.0163160861680099 mirMAP -0.19739104901179 0.00088619253374349 NA NA NA hsa-miR-30a-5p WNT7B -0.48552268915326 0.730142516403566 -0.955718862585083 0.0163160861680099 miRNATAP -0.244710473588963 1.09537488646518e-06 NA NA NA hsa-miR-30b-3p WNT7B 0.353268230055879 0.0503719815958775 -0.955718862585083 0.0163160861680099 MirTarget;mirMAP -0.199927265231065 0.000916083804937799 NA NA NA hsa-miR-30c-5p WNT7B 0.2904764284977 0.738803502565399 -0.955718862585083 0.0163160861680099 miRNATAP -0.455544291260138 2.11209121770824e-09 NA NA NA hsa-miR-326 WNT7B 0.215485710119405 0.487218662995766 -0.955718862585083 0.0163160861680099 MirTarget;miRanda -0.161789035877396 9.64577721935033e-05 NA NA NA hsa-miR-335-5p WNT7B 0.0404259244994374 0.914858946651589 -0.955718862585083 0.0163160861680099 miRNAWalker2_validate -0.23895557225465 6.17708068119425e-09 NA NA NA hsa-miR-491-5p WNT7B -0.0426464166135634 0.817052196076797 -0.955718862585083 0.0163160861680099 mirMAP -0.270664526249752 2.96434624276917e-06 NA NA NA hsa-miR-505-3p WNT7B 1.82926040846064 3.48624069415488e-05 -0.955718862585083 0.0163160861680099 miRNATAP -0.25367826265264 7.46180280225906e-06 NA NA NA hsa-miR-1271-5p WNT9A 0.734083414954632 0.00016191462050357 -0.326244959645828 0.120183134713694 mirMAP -0.151077426632908 0.000116310190119482 NA NA NA hsa-miR-148a-3p WNT9A 0.722527444447689 0.597269550476641 -0.326244959645828 0.120183134713694 mirMAP -0.298084226700717 2.38424942045375e-09 NA NA NA hsa-miR-148b-3p WNT9A 0.139560003671114 0.825716083905455 -0.326244959645828 0.120183134713694 mirMAP -0.216690484061052 0.000659770444792974 NA NA NA hsa-miR-15b-5p WNT9A 0.687228605707872 0.304427884697749 -0.326244959645828 0.120183134713694 mirMAP -0.160780744423949 0.00213391068310254 NA NA NA hsa-miR-16-5p WNT9A 0.608716035131087 0.441059798918702 -0.326244959645828 0.120183134713694 mirMAP -0.294351524109689 2.19404233093207e-06 NA NA NA hsa-miR-181a-2-3p WNT9A 0.682351266467006 0.429599916993576 -0.326244959645828 0.120183134713694 mirMAP -0.200099377422022 0.00380063581033883 NA NA NA hsa-miR-193a-3p WNT9A 0.183521555169311 0.61877899263343 -0.326244959645828 0.120183134713694 mirMAP -0.305391600401298 3.90157370096497e-08 NA NA NA hsa-miR-195-5p WNT9A -0.130193686630835 0.80220061875718 -0.326244959645828 0.120183134713694 mirMAP -0.196363300820022 0.000137496059895827 NA NA NA hsa-miR-28-5p WNT9A 0.698472090600538 0.237744307568605 -0.326244959645828 0.120183134713694 mirMAP -0.292797790744078 0.000600350405048975 NA NA NA hsa-miR-32-5p WNT9A 0.531860098119996 0.195500436097555 -0.326244959645828 0.120183134713694 mirMAP -0.216445530743276 3.06978747423399e-05 NA NA NA hsa-miR-331-3p WNT9A 0.259002302197189 0.507018043618617 -0.326244959645828 0.120183134713694 mirMAP -0.137832471681534 0.00151040501960236 NA NA NA hsa-miR-335-5p WNT9A 0.0404259244994374 0.914858946651589 -0.326244959645828 0.120183134713694 miRNAWalker2_validate -0.146714794864289 9.92998698360538e-06 NA NA NA hsa-miR-363-3p WNT9A 0.253217343926133 0.484386936820357 -0.326244959645828 0.120183134713694 mirMAP -0.126772985407334 8.48022074883423e-05 NA NA NA hsa-miR-424-5p WNT9A 0.584229437974506 0.326869614530055 -0.326244959645828 0.120183134713694 mirMAP -0.203387678407749 6.84865574984046e-07 NA NA NA hsa-miR-497-5p WNT9A 0.0181393084471777 0.96777886220216 -0.326244959645828 0.120183134713694 mirMAP -0.228181412286226 5.31377710156938e-06 NA NA NA hsa-miR-532-3p WNT9A 1.34912309508196 0.00133218111817202 -0.326244959645828 0.120183134713694 mirMAP -0.144881932218838 0.000552241596034881 NA NA NA hsa-miR-708-5p WNT9A 0.0514323700721242 0.910357550595786 -0.326244959645828 0.120183134713694 mirMAP -0.12045189873946 0.00968711444884768 NA NA NA