miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p AIFM1 -0.328069937201898 0.000464344093744051 -0.385341500009001 0.000487220407124204 TargetScan;miRNATAP -0.156878186610717 0.00688659078633595 NA NA NA hsa-let-7d-5p AIFM1 0.0503292020123807 0.702580311853671 -0.385341500009001 0.000487220407124204 miRNATAP -0.227865460454543 2.10775715366441e-08 NA NA NA hsa-let-7e-5p AIFM1 0.0350298755544731 0.811068614727804 -0.385341500009001 0.000487220407124204 miRNATAP -0.265623018485343 1.69105242803182e-13 NA NA NA hsa-let-7i-5p AIFM1 -0.14267936165213 0.154141689875847 -0.385341500009001 0.000487220407124204 miRNATAP -0.270178971706901 5.63343817647883e-07 NA NA NA hsa-miR-125a-5p AIFM1 -0.91219969372382 1.38256246489548e-07 -0.385341500009001 0.000487220407124204 miRanda -0.143782175885177 2.45198736443818e-06 NA NA NA hsa-miR-20a-3p AIFM1 -0.318177901603857 0.0467885456739855 -0.385341500009001 0.000487220407124204 miRNATAP -0.114832354479707 0.000674172928292269 NA NA NA hsa-miR-425-5p AIFM1 0.585974239943864 2.23063410931402e-05 -0.385341500009001 0.000487220407124204 miRNATAP -0.15215692760595 8.49396965138554e-05 NA NA NA hsa-miR-21-5p AKT2 1.51084295924322 1.54551622173259e-34 -0.343608685894869 1.25471482871759e-05 miRNAWalker2_validate -0.246625533117166 4.43585626011661e-19 NA NA NA hsa-miR-330-5p AKT2 0.442231058604099 0.0053308560843808 -0.343608685894869 1.25471482871759e-05 miRanda -0.10429759179516 1.49133299948889e-05 NA NA NA hsa-miR-342-3p AKT2 -0.319677314984262 0.0449813878317147 -0.343608685894869 1.25471482871759e-05 mirMAP -0.124944719707983 1.72780303356483e-07 NA NA NA hsa-miR-106b-5p AKT3 0.648901865047099 8.24870862047885e-09 -0.658799312069129 0.000471762262250455 miRNATAP -0.257549207275002 0.00147770551388523 NA NA NA hsa-miR-107 AKT3 0.241662461253461 0.0170788899505389 -0.658799312069129 0.000471762262250455 PITA;miRanda -0.603074134996255 1.95007791380395e-11 NA NA NA hsa-miR-122-5p AKT3 -1.23907441373955 4.42181244888642e-06 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase -0.282597613468804 3.13172096832783e-18 24244539 miR 122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3; Here we identify AKT3 as a novel and direct target of miR-122; Restoration of miR-122 expression in HCC cell lines decreases AKT3 levels inhibits cell migration and proliferation and induces apoptosis; These anti-tumor phenotypes can be rescued by reconstitution of AKT3 expression indicating the essential role of AKT3 in miR-122 mediated HCC transformation; Our data strongly suggest that miR-122 is a tumor suppressor that targets AKT3 to regulate tumorigenesis in HCCs and a potential therapeutic candidate for liver cancer tumorigenesis;cell migration liver cancer hsa-miR-146b-5p AKT3 0.419719546795449 0.0457375823220155 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate -0.159678144375669 0.000263366078999813 NA NA NA hsa-miR-15a-5p AKT3 0.349521211668244 0.000770735998804736 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265425410812535 0.00291348888530609 NA NA NA hsa-miR-17-3p AKT3 0.410352776142368 0.00422200500748636 -0.658799312069129 0.000471762262250455 miRNATAP -0.350392140268267 3.46133659001702e-08 NA NA NA hsa-miR-17-5p AKT3 0.698861147045461 2.43854106455398e-05 -0.658799312069129 0.000471762262250455 TargetScan;miRNATAP -0.290786763807918 1.04942988053081e-07 NA NA NA hsa-miR-20a-5p AKT3 0.854326758727003 5.04256669663285e-07 -0.658799312069129 0.000471762262250455 miRNATAP -0.294574079686222 2.60181650003526e-08 NA NA NA hsa-miR-32-3p AKT3 0.219109440121582 0.207217051619543 -0.658799312069129 0.000471762262250455 mirMAP -0.225932925933496 3.62088303609835e-05 NA NA NA hsa-miR-33a-3p AKT3 -0.683025859637737 1.01106097756419e-05 -0.658799312069129 0.000471762262250455 mirMAP -0.229716914608906 0.000100074832030455 NA NA NA hsa-miR-362-3p AKT3 0.814007335895913 2.00108618836568e-09 -0.658799312069129 0.000471762262250455 miRanda -0.223301194831745 0.00083465748836002 NA NA NA hsa-miR-362-5p AKT3 0.717921690799312 1.68392734504524e-05 -0.658799312069129 0.000471762262250455 PITA;TargetScan;miRNATAP -0.147261080417749 0.00734435768679755 NA NA NA hsa-miR-374a-5p AKT3 0.016390363747302 0.869784217438621 -0.658799312069129 0.000471762262250455 mirMAP -0.277843537840681 0.00293899073092604 NA NA NA hsa-miR-502-3p AKT3 0.659598854007546 3.01316453996423e-08 -0.658799312069129 0.000471762262250455 miRNATAP -0.256952206617794 0.000795069967308112 NA NA NA hsa-miR-616-5p AKT3 0.150569904638223 0.402836556304524 -0.658799312069129 0.000471762262250455 mirMAP -0.200000357827185 9.73725948226915e-05 NA NA NA hsa-miR-93-5p AKT3 1.39518349670953 2.84167728726712e-25 -0.658799312069129 0.000471762262250455 miRNATAP -0.283992832133781 1.04884093066001e-05 NA NA NA hsa-miR-30d-3p ATM -0.120562286038759 0.329549534782125 -0.236058797850924 0.0173776926910908 mirMAP -0.138156674894502 0.00042794166032829 24345332 miR-30d has been observed to be significantly down-regulated in human anaplastic thyroid carcinoma ATC and is believed to be an important event in thyroid cell transformation; In this study we found that miR-30d has a critical role in modulating sensitivity of ATC cells to cisplatin a commonly used chemotherapeutic drug for treatment of this neoplasm; Using a mimic of miR-30d we demonstrated that miR-30d could negatively regulate the expression of beclin 1 a key autophagy gene leading to suppression of the cisplatin-activated autophagic response that protects ATC cells from apoptosis; We further showed that inhibition of the beclin 1-mediated autophagy by the miR-30d mimic sensitized ATC cells to cisplatin both in vitro cell culture and in vivo animal xenograft model; These results suggest that dysregulation of miR-30d in ATC cells is responsible for the insensitivity to cisplatin by promoting autophagic survival; Thus miR-30d may be exploited as a potential target for therapeutic intervention in the treatment of ATC drug resistance;poor survival thyroid cancer hsa-miR-339-5p ATM 0.280589919878422 0.0355660282647215 -0.236058797850924 0.0173776926910908 miRanda -0.1044932927788 0.00399236512159519 NA NA NA hsa-miR-455-5p ATM -0.270546034117157 0.0581320703577731 -0.236058797850924 0.0173776926910908 miRanda -0.118715671502599 0.000450782297458542 NA NA NA hsa-miR-30a-5p BAX -0.626257932887855 0.000108198196973765 0.800291917132606 7.28210427550269e-13 miRNAWalker2_validate -0.117791332970104 0.00058384847557231 NA NA NA hsa-miR-365a-3p BAX 0.164591326307714 0.15325084963213 0.800291917132606 7.28210427550269e-13 miRNAWalker2_validate -0.229448386158489 2.12152243741233e-06 24216611 MiR 365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro apoptotic regulator BAX drug resistance pancreatic cancer hsa-miR-103a-3p BCL2 0.765568928457606 3.05497476509383e-12 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate -0.276206643708183 3.69212207145036e-05 NA NA NA hsa-miR-130b-5p BCL2 0.170599813152408 0.337611586432771 -0.34630447089245 0.0249701729768122 mirMAP -0.1684334796147 6.63359359340854e-05 27364335 The level of microRNA-130b in relationship with the expression of PPARγ VEGF-A BCL-2 and apoptosis were analyzed in 91 lung cancer patient samples using immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL assay on tissue microarrays; In vitro and in vivo miR-130b enrichment associated with down-regulation of PPARγ up-regulation of VEGF-A and BCL-2 and decreased apoptosis lung cancer hsa-miR-148a-3p BCL2 -0.748702855596996 3.93313343865641e-07 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.309765293468013 4.08540378699783e-10 21455217;23975374 MiR 148a promotes apoptosis by targeting Bcl 2 in colorectal cancer;MiR 148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl 2; Using western blot and luciferase activity assay CCKBR and Bcl-2 were identified as targets of miR-148a; Moreover we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a ; colorectal cancer;pancreatic cancer hsa-miR-17-5p BCL2 0.698861147045461 2.43854106455398e-05 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.3141879354563 9.49080059686353e-13 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-186-5p BCL2 -0.060103391373687 0.535288717081205 -0.34630447089245 0.0249701729768122 mirMAP -0.253682116313365 0.00124603296329075 NA NA NA hsa-miR-192-5p BCL2 -0.50188499512787 0.00344713341196035 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate -0.343159016245154 5.19113742652329e-16 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-20a-3p BCL2 -0.318177901603857 0.0467885456739855 -0.34630447089245 0.0249701729768122 mirMAP -0.241984307767668 2.15054512819723e-07 NA NA NA hsa-miR-20a-5p BCL2 0.854326758727003 5.04256669663285e-07 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.309280985956287 4.00465486003896e-13 NA NA NA hsa-miR-32-3p BCL2 0.219109440121582 0.207217051619543 -0.34630447089245 0.0249701729768122 mirMAP -0.197220723036098 9.60236464107476e-06 NA NA NA hsa-miR-365a-3p BCL2 0.164591326307714 0.15325084963213 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.325345655719122 6.00535770562877e-07 NA NA NA hsa-miR-455-5p BCL2 -0.270546034117157 0.0581320703577731 -0.34630447089245 0.0249701729768122 mirMAP -0.187920872762485 0.00036775461526632 NA NA NA hsa-miR-590-5p BCL2 -0.103355559980404 0.310027295317092 -0.34630447089245 0.0249701729768122 miRanda -0.288806204300719 0.000105733783342118 NA NA NA hsa-miR-616-5p BCL2 0.150569904638223 0.402836556304524 -0.34630447089245 0.0249701729768122 mirMAP -0.279996287836879 9.62044185440687e-12 NA NA NA hsa-miR-618 BCL2 0.13539895350352 0.517145913114103 -0.34630447089245 0.0249701729768122 mirMAP -0.20993134438608 1.19441927849968e-08 NA NA NA hsa-miR-330-5p BCL2L1 0.442231058604099 0.0053308560843808 0.0225608953357561 0.827445946886033 PITA;miRanda;miRNATAP -0.154730615864034 7.70545597695822e-07 NA NA NA hsa-miR-342-3p BCL2L1 -0.319677314984262 0.0449813878317147 0.0225608953357561 0.827445946886033 PITA;miRanda;miRNATAP -0.123843624743073 7.98408137042515e-05 NA NA NA hsa-miR-342-5p BCL2L1 -0.780720763816797 5.21703298730986e-07 0.0225608953357561 0.827445946886033 miRNATAP -0.106591893041378 0.000835493298714261 NA NA NA hsa-miR-484 BCL2L1 0.0857240033709656 0.453982056282229 0.0225608953357561 0.827445946886033 miRNAWalker2_validate -0.214137045460272 1.02827848229123e-06 NA NA NA hsa-miR-140-5p BID -0.220106443070144 0.0140713197101242 0.212028711841568 0.0751625972679542 miRanda -0.214836635124566 0.00100941241708294 NA NA NA hsa-miR-24-1-5p BIRC3 -1.3235267368749 6.56628864624956e-23 0.345666703943572 0.159762716827606 MirTarget -0.298989455936807 0.000402007450494458 NA NA NA hsa-miR-26b-5p BIRC3 -1.10804856399744 4.14176110314282e-22 0.345666703943572 0.159762716827606 mirMAP -0.351728818879341 0.000406492135983019 NA NA NA hsa-miR-374a-5p BIRC3 0.016390363747302 0.869784217438621 0.345666703943572 0.159762716827606 mirMAP -0.556409792541405 3.74975496877103e-06 NA NA NA hsa-miR-374b-5p BIRC3 -0.307538028546424 0.0030079617545972 0.345666703943572 0.159762716827606 mirMAP -0.302534509430598 0.00930293938825019 NA NA NA hsa-miR-651-5p BIRC3 -0.244364876887077 0.0817536678437599 0.345666703943572 0.159762716827606 MirTarget -0.276810228320716 0.00126215570675979 NA NA NA hsa-miR-664a-3p BIRC3 0.485807855553031 0.000732553249798598 0.345666703943572 0.159762716827606 mirMAP -0.269205785296152 0.00117865263516174 NA NA NA hsa-miR-140-5p CAPN1 -0.220106443070144 0.0140713197101242 0.203975388211385 0.0133808943356494 miRanda;miRNATAP -0.150314202932084 0.000874565895684601 NA NA NA hsa-miR-101-3p CAPN2 -1.48176407980989 3.98950707385704e-31 0.655194969240925 1.21295078937538e-07 miRNAWalker2_validate;MirTarget -0.211136325324757 1.73986621368963e-06 NA NA NA hsa-miR-107 CAPN2 0.241662461253461 0.0170788899505389 0.655194969240925 1.21295078937538e-07 miRanda -0.196117552086705 0.00125089180439756 NA NA NA hsa-miR-16-2-3p CAPN2 -0.0336420826463706 0.805158952566973 0.655194969240925 1.21295078937538e-07 mirMAP -0.154414276957788 0.000599368567853864 NA NA NA hsa-miR-20a-3p CAPN2 -0.318177901603857 0.0467885456739855 0.655194969240925 1.21295078937538e-07 MirTarget -0.130110134544505 0.000666312924360847 NA NA NA hsa-miR-33a-3p CAPN2 -0.683025859637737 1.01106097756419e-05 0.655194969240925 1.21295078937538e-07 mirMAP -0.129476598310856 0.000960162955941016 NA NA NA hsa-miR-590-3p CAPN2 -0.473167498047808 1.76652934637227e-05 0.655194969240925 1.21295078937538e-07 miRanda -0.223109477706343 5.17584726080661e-05 NA NA NA hsa-miR-590-5p CAPN2 -0.103355559980404 0.310027295317092 0.655194969240925 1.21295078937538e-07 miRanda -0.244661447544334 5.15285994880349e-05 NA NA NA hsa-let-7g-5p CASP3 -0.461294133285527 2.17210114729901e-05 0.309149151776334 0.000465712323457523 MirTarget;miRNATAP -0.107118384912517 0.00693887247949783 NA NA NA hsa-miR-374b-5p CASP3 -0.307538028546424 0.0030079617545972 0.309149151776334 0.000465712323457523 mirMAP -0.143675176440622 0.00057864418465262 NA NA NA hsa-miR-455-5p CASP8 -0.270546034117157 0.0581320703577731 0.329003138913902 0.000294949473828384 miRanda -0.154954229285754 5.1724046517642e-07 NA NA NA hsa-miR-542-3p CASP8 -1.31351015149842 3.64642423288576e-22 0.329003138913902 0.000294949473828384 miRanda -0.128105307061659 3.53556200230067e-05 NA NA NA hsa-miR-107 CFLAR 0.241662461253461 0.0170788899505389 -0.332671102072829 2.00694636367654e-06 miRanda -0.152301413002496 6.91205696307911e-06 NA NA NA hsa-miR-455-5p CFLAR -0.270546034117157 0.0581320703577731 -0.332671102072829 2.00694636367654e-06 miRanda -0.110213584277723 3.95957481119902e-06 NA NA NA hsa-miR-660-5p CFLAR 0.989755850734071 5.69930767464937e-14 -0.332671102072829 2.00694636367654e-06 mirMAP -0.133551077375969 9.40621335652891e-08 NA NA NA hsa-miR-15a-5p CHUK 0.349521211668244 0.000770735998804736 -0.19932080126218 0.00863163957240649 miRNAWalker2_validate;miRTarBase;MirTarget -0.122536038974783 0.000565424625908096 NA NA NA hsa-miR-15b-5p CHUK 0.230566941413564 0.0824765001857479 -0.19932080126218 0.00863163957240649 MirTarget -0.118017359725558 2.06238744655946e-05 NA NA NA hsa-miR-16-5p CHUK -0.398577235179603 0.000101598495180191 -0.19932080126218 0.00863163957240649 miRNAWalker2_validate;miRTarBase;MirTarget -0.150607357209835 2.62400382273556e-05 NA NA NA hsa-miR-23a-3p CHUK -0.178875974460574 0.135978273540604 -0.19932080126218 0.00863163957240649 MirTarget -0.100438227795724 0.00114468004476388 NA NA NA hsa-miR-339-5p CHUK 0.280589919878422 0.0355660282647215 -0.19932080126218 0.00863163957240649 miRanda -0.12221351609504 8.92727609693918e-06 NA NA NA hsa-miR-590-5p CHUK -0.103355559980404 0.310027295317092 -0.19932080126218 0.00863163957240649 miRanda -0.11766978557823 0.00128889069327197 NA NA NA hsa-miR-19a-3p CSF2RB 1.01712596153672 2.57753201450625e-07 -0.510057706101157 0.00683192745956236 MirTarget -0.120533382582832 0.00885126081922571 NA NA NA hsa-miR-19b-3p CSF2RB 0.601279551368824 0.00016685097085251 -0.510057706101157 0.00683192745956236 MirTarget -0.154504842048333 0.0071335754861484 NA NA NA hsa-miR-204-5p CSF2RB -0.537962150012103 0.0330895493358849 -0.510057706101157 0.00683192745956236 MirTarget -0.111334390280645 0.00224060172110844 NA NA NA hsa-miR-30b-3p CSF2RB -0.439724365151373 0.000947180503583586 -0.510057706101157 0.00683192745956236 MirTarget -0.201103593319895 0.00366034123496103 NA NA NA hsa-miR-455-5p CSF2RB -0.270546034117157 0.0581320703577731 -0.510057706101157 0.00683192745956236 miRanda -0.37382538214599 4.3712193850043e-09 NA NA NA hsa-miR-532-5p CSF2RB 1.02729546510601 9.93318913966636e-16 -0.510057706101157 0.00683192745956236 MirTarget -0.3331966059366 1.42783661157539e-06 NA NA NA hsa-miR-361-5p CYCS 0.233202959858696 0.00961572812255327 0.261279109661729 0.0151863050548952 miRNAWalker2_validate -0.172862186931422 0.00330618553619798 NA NA NA hsa-let-7b-5p DFFA -0.959013717270803 5.95127281258643e-11 0.0678724457086854 0.419098982330631 miRNAWalker2_validate -0.107067404976435 7.69501690805216e-05 NA NA NA hsa-miR-26a-5p DFFA -0.963792031426845 1.83360999387345e-22 0.0678724457086854 0.419098982330631 mirMAP -0.160393358100013 4.25358425511916e-05 NA NA NA hsa-miR-365a-3p DFFB 0.164591326307714 0.15325084963213 0.295356110131766 0.00330961478217344 MirTarget -0.121567381773669 0.00456403483310331 NA NA NA hsa-miR-130b-3p ENDOD1 0.687190305027546 0.000109068658562255 -0.998600185815336 9.70620010845927e-08 MirTarget -0.313603454995876 7.35985290343435e-10 NA NA NA hsa-miR-16-1-3p ENDOD1 0.392360028038559 0.00112481918108198 -0.998600185815336 9.70620010845927e-08 mirMAP -0.453613251765932 2.12551750317036e-09 NA NA NA hsa-miR-192-5p ENDOD1 -0.50188499512787 0.00344713341196035 -0.998600185815336 9.70620010845927e-08 miRNAWalker2_validate -0.463066599557689 2.93930391048484e-19 NA NA NA hsa-miR-193b-3p ENDOD1 -0.166697207281748 0.272022543069482 -0.998600185815336 9.70620010845927e-08 miRNAWalker2_validate -0.220787086438548 0.000300490167878324 NA NA NA hsa-miR-19a-3p ENDOD1 1.01712596153672 2.57753201450625e-07 -0.998600185815336 9.70620010845927e-08 mirMAP -0.284646820540721 3.68998548154196e-10 NA NA NA hsa-miR-19b-3p ENDOD1 0.601279551368824 0.00016685097085251 -0.998600185815336 9.70620010845927e-08 mirMAP -0.342674812633697 1.56455489467667e-09 NA NA NA hsa-miR-20a-3p ENDOD1 -0.318177901603857 0.0467885456739855 -0.998600185815336 9.70620010845927e-08 MirTarget -0.275800394156558 1.6332110332701e-06 NA NA NA hsa-miR-224-3p ENDOD1 1.40770116795301 1.31426607144612e-08 -0.998600185815336 9.70620010845927e-08 mirMAP -0.101105612989004 0.00660341538433555 NA NA NA hsa-miR-361-5p ENDOD1 0.233202959858696 0.00961572812255327 -0.998600185815336 9.70620010845927e-08 MirTarget;miRanda -0.624337627001858 1.021101804084e-09 NA NA NA hsa-miR-3613-5p ENDOD1 0.108670896316992 0.426512924240953 -0.998600185815336 9.70620010845927e-08 MirTarget -0.205615506623261 0.00253521008468026 NA NA NA hsa-miR-362-3p ENDOD1 0.814007335895913 2.00108618836568e-09 -0.998600185815336 9.70620010845927e-08 miRanda -0.338617228290447 3.51718335843851e-07 NA NA NA hsa-miR-589-3p ENDOD1 1.16846704028095 5.88525574424201e-11 -0.998600185815336 9.70620010845927e-08 mirMAP -0.209866246211484 4.75340448905647e-05 NA NA NA hsa-miR-589-5p ENDOD1 1.18593770505086 1.01781241960531e-22 -0.998600185815336 9.70620010845927e-08 MirTarget -0.56350516802131 1.42496533440957e-15 NA NA NA hsa-miR-542-3p EXOG -1.31351015149842 3.64642423288576e-22 0.809117667842654 9.16571142499629e-17 miRanda -0.114238895736061 0.000904309475997506 NA NA NA hsa-miR-106a-5p FAS -0.464229535269236 0.009724944358047 -1.01888565147264 1.11378826495697e-07 miRNAWalker2_validate;miRTarBase -0.302797529669468 5.79007536295077e-09 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-21-5p FAS 1.51084295924322 1.54551622173259e-34 -1.01888565147264 1.11378826495697e-07 miRNAWalker2_validate -0.345881974093154 8.950367188801e-07 24710931 miR 21 targets Fas ligand mediated apoptosis in breast cancer cell line MCF 7 breast cancer hsa-miR-338-3p FAS 0.543135607704581 0.00461167747143826 -1.01888565147264 1.11378826495697e-07 miRanda -0.23029320652752 2.57971450360388e-06 NA NA NA hsa-miR-361-5p FAS 0.233202959858696 0.00961572812255327 -1.01888565147264 1.11378826495697e-07 miRanda -0.400344969968845 0.000164688479523076 NA NA NA hsa-miR-590-5p FAS -0.103355559980404 0.310027295317092 -1.01888565147264 1.11378826495697e-07 miRanda -0.564263807321375 1.14802968070722e-09 NA NA NA hsa-miR-98-5p FAS -0.0487189107419432 0.715911066732548 -1.01888565147264 1.11378826495697e-07 miRNAWalker2_validate -0.184416097033268 0.00981276415174906 NA NA NA hsa-miR-25-3p FASLG 0.633062563556379 3.68686354834328e-10 -0.789267794109529 0.000910923617828174 miRNATAP -0.409147266425705 0.000319496225971281 NA NA NA hsa-miR-125a-5p IKBKG -0.91219969372382 1.38256246489548e-07 0.660366120199928 1.71867865546723e-06 miRanda -0.219029418282295 9.51829321882113e-09 NA NA NA hsa-miR-143-3p IKBKG -0.584123869220553 0.000907217687997436 0.660366120199928 1.71867865546723e-06 mirMAP -0.169551761758995 9.09905571393035e-06 NA NA NA hsa-miR-200a-3p IKBKG -1.49949292595657 3.18410995256133e-05 0.660366120199928 1.71867865546723e-06 mirMAP -0.100439586597671 5.62621816828972e-08 NA NA NA hsa-miR-24-3p IKBKG -0.257825594021966 0.00689742600215061 0.660366120199928 1.71867865546723e-06 mirMAP -0.287544034512102 5.8686253015948e-05 NA NA NA hsa-miR-3065-3p IKBKG -1.04244468016704 4.60743424372577e-05 0.660366120199928 1.71867865546723e-06 mirMAP -0.115721435331344 9.61381024877344e-06 NA NA NA hsa-miR-320a IKBKG 0.325285936317332 0.0221415065838824 0.660366120199928 1.71867865546723e-06 mirMAP -0.182311319218153 0.000133876392194021 NA NA NA hsa-miR-320b IKBKG 0.0919652022571331 0.607981643616945 0.660366120199928 1.71867865546723e-06 mirMAP -0.132285547849802 0.000522961413620221 NA NA NA hsa-miR-335-5p IKBKG -1.61347836513558 1.62757083289711e-19 0.660366120199928 1.71867865546723e-06 mirMAP -0.273399124951207 9.32430291537739e-15 NA NA NA hsa-miR-338-5p IKBKG -0.221898432884726 0.252390988727086 0.660366120199928 1.71867865546723e-06 mirMAP -0.206675822417303 2.68501101428877e-09 NA NA NA hsa-miR-376c-3p IKBKG -1.78544013329054 1.82972185127691e-10 0.660366120199928 1.71867865546723e-06 mirMAP -0.14083607992738 1.85430800686914e-09 NA NA NA hsa-miR-542-3p IKBKG -1.31351015149842 3.64642423288576e-22 0.660366120199928 1.71867865546723e-06 mirMAP -0.292142688932618 4.40119371820177e-10 NA NA NA hsa-miR-17-3p IL1R1 0.410352776142368 0.00422200500748636 -1.01045381057689 4.50684679449702e-13 mirMAP -0.39073755100076 1.02125622521434e-16 NA NA NA hsa-miR-181a-5p IL1R1 0.250113435902954 0.0551933249319293 -1.01045381057689 4.50684679449702e-13 mirMAP -0.2322434157224 1.42776581461954e-05 NA NA NA hsa-miR-181b-5p IL1R1 0.488256489401108 0.00105321129419701 -1.01045381057689 4.50684679449702e-13 mirMAP -0.246016811028355 1.07107101412662e-07 NA NA NA hsa-miR-29b-3p IL1RAP -0.348885528720517 0.0121441341291285 -2.2850961688971 4.44698063203837e-31 MirTarget;miRNATAP -0.239343862185629 0.00132489573832657 NA NA NA hsa-miR-421 IL1RAP 0.941856334694081 6.12167297054077e-08 -2.2850961688971 4.44698063203837e-31 MirTarget;miRanda -0.179170930023216 0.00236521232674224 NA NA NA hsa-miR-93-5p IL1RAP 1.39518349670953 2.84167728726712e-25 -2.2850961688971 4.44698063203837e-31 MirTarget -0.289423051870737 6.58804226779057e-05 NA NA NA hsa-miR-142-3p IRAK1 -1.4243101967815 1.92609481097765e-14 1.21767339008179 3.30121906631099e-23 PITA;miRanda;miRNATAP -0.103953357056079 0.00153955309513343 NA NA NA hsa-miR-328-3p IRAK1 -0.547466865311955 6.8359574451572e-06 1.21767339008179 3.30121906631099e-23 miRNAWalker2_validate -0.172704549123244 0.000809428396103482 NA NA NA hsa-miR-188-5p IRAK3 1.11646899351496 9.56686958408598e-11 -1.13497721915457 1.79851071172739e-09 mirMAP -0.158734470858165 0.0029008108464997 NA NA NA hsa-miR-20a-3p IRAK3 -0.318177901603857 0.0467885456739855 -1.13497721915457 1.79851071172739e-09 mirMAP -0.175357327305712 0.00282281922197201 NA NA NA hsa-miR-224-3p IRAK3 1.40770116795301 1.31426607144612e-08 -1.13497721915457 1.79851071172739e-09 mirMAP -0.128614239192543 0.000620367595349101 NA NA NA hsa-miR-25-3p IRAK3 0.633062563556379 3.68686354834328e-10 -1.13497721915457 1.79851071172739e-09 mirMAP -0.496027831935383 4.28679741709112e-08 NA NA NA hsa-miR-32-5p IRAK3 0.0806126674664016 0.548984992497432 -1.13497721915457 1.79851071172739e-09 mirMAP -0.204454930256192 0.00353280923858211 NA NA NA hsa-miR-3200-3p IRAK3 1.40312896232918 1.8232142177606e-07 -1.13497721915457 1.79851071172739e-09 mirMAP -0.144065146663431 5.67390601970441e-05 NA NA NA hsa-miR-324-5p IRAK3 0.372933276649782 0.00592280066108904 -1.13497721915457 1.79851071172739e-09 miRanda -0.190946568884495 0.00586377402152574 NA NA NA hsa-miR-33a-5p IRAK3 -0.767474460958522 1.09948756118522e-05 -1.13497721915457 1.79851071172739e-09 mirMAP -0.167941780649256 0.00159158216708375 NA NA NA hsa-miR-361-5p IRAK3 0.233202959858696 0.00961572812255327 -1.13497721915457 1.79851071172739e-09 miRanda;mirMAP -0.366492329047263 0.000485264246384617 NA NA NA hsa-miR-452-3p IRAK3 1.76909792952222 2.98172274671408e-10 -1.13497721915457 1.79851071172739e-09 mirMAP -0.112416875181292 0.00056065737846136 NA NA NA hsa-miR-589-3p IRAK3 1.16846704028095 5.88525574424201e-11 -1.13497721915457 1.79851071172739e-09 mirMAP -0.202545194522017 0.000106710303655112 NA NA NA hsa-miR-616-5p IRAK3 0.150569904638223 0.402836556304524 -1.13497721915457 1.79851071172739e-09 mirMAP -0.199250897246326 0.000132887689303882 NA NA NA hsa-miR-660-5p IRAK3 0.989755850734071 5.69930767464937e-14 -1.13497721915457 1.79851071172739e-09 mirMAP -0.276330936099034 6.11647347583833e-05 NA NA NA hsa-miR-92a-3p IRAK3 0.212391012518195 0.134292268089997 -1.13497721915457 1.79851071172739e-09 mirMAP -0.289084278502964 1.15719165104441e-05 NA NA NA hsa-miR-30d-3p IRAK4 -0.120562286038759 0.329549534782125 0.0196456384958048 0.750527352134966 mirMAP -0.131118951269709 4.3287196994492e-08 NA NA NA hsa-miR-17-3p MAP3K14 0.410352776142368 0.00422200500748636 -0.256732855579524 0.0805960527428211 MirTarget -0.134473480210187 0.00705656422421302 NA NA NA hsa-miR-17-5p MAP3K14 0.698861147045461 2.43854106455398e-05 -0.256732855579524 0.0805960527428211 MirTarget -0.200236479730088 2.50369988878285e-06 NA NA NA hsa-miR-20a-5p MAP3K14 0.854326758727003 5.04256669663285e-07 -0.256732855579524 0.0805960527428211 MirTarget -0.157807215094265 0.000138930673437178 NA NA NA hsa-miR-874-3p MAP3K14 -1.07043026298634 2.09564226589678e-07 -0.256732855579524 0.0805960527428211 MirTarget -0.122908909256529 0.000312223440563301 NA NA NA hsa-miR-330-5p MYD88 0.442231058604099 0.0053308560843808 -1.09504958245187 7.49679043456039e-31 MirTarget;miRanda -0.158294311884371 3.16398911506774e-07 NA NA NA hsa-miR-660-5p MYD88 0.989755850734071 5.69930767464937e-14 -1.09504958245187 7.49679043456039e-31 MirTarget -0.17212659556565 2.27550637162311e-06 NA NA NA hsa-miR-15a-5p NFKB1 0.349521211668244 0.000770735998804736 -0.538916955748098 1.42993670239858e-08 miRNAWalker2_validate -0.153048958379264 0.000730484492411411 NA NA NA hsa-miR-548j-5p NFKB1 0.251239647701947 0.171361975450222 -0.538916955748098 1.42993670239858e-08 MirTarget -0.106885227436574 4.88574003092244e-05 NA NA NA hsa-miR-92a-3p NFKB1 0.212391012518195 0.134292268089997 -0.538916955748098 1.42993670239858e-08 miRNAWalker2_validate -0.147016189975437 8.47280185007855e-06 NA NA NA hsa-miR-423-5p NGF 0.698807775906485 1.02195196334612e-11 -1.13456502234037 7.24473953628721e-08 MirTarget;miRNATAP -0.447502128127762 6.35933337883299e-06 NA NA NA hsa-miR-17-5p PIK3CA 0.698861147045461 2.43854106455398e-05 -0.417502897789422 0.000144089141837096 miRNAWalker2_validate -0.140034439363479 1.22830047865626e-05 NA NA NA hsa-miR-339-5p PIK3CA 0.280589919878422 0.0355660282647215 -0.417502897789422 0.000144089141837096 miRanda -0.161250958910826 6.10867364493006e-05 NA NA NA hsa-miR-501-5p PIK3CA 1.15231083477882 2.98906150004088e-10 -0.417502897789422 0.000144089141837096 mirMAP -0.110297544989421 0.000121810192831398 NA NA NA hsa-miR-126-5p PIK3CB -0.428561469405594 6.6035585844222e-05 0.100967159570933 0.165951003911767 mirMAP -0.182730257201379 1.71015167377407e-08 NA NA NA hsa-miR-204-5p PIK3CB -0.537962150012103 0.0330895493358849 0.100967159570933 0.165951003911767 miRNATAP -0.108408817404481 9.83805003133513e-16 NA NA NA hsa-miR-32-5p PIK3CB 0.0806126674664016 0.548984992497432 0.100967159570933 0.165951003911767 miRNATAP -0.140663620385439 6.63155819716864e-08 NA NA NA hsa-miR-1468-5p PIK3CD -1.21475558175193 2.52286949987832e-09 -0.877858532886072 2.39332269929579e-06 MirTarget -0.114605918546385 0.00956114952826845 NA NA NA hsa-miR-30b-3p PIK3CD -0.439724365151373 0.000947180503583586 -0.877858532886072 2.39332269929579e-06 MirTarget -0.241027174305288 0.000454965508091255 NA NA NA hsa-miR-30d-5p PIK3CD 0.718283816348023 2.47422074061352e-08 -0.877858532886072 2.39332269929579e-06 MirTarget;miRNATAP -0.313277633599958 7.26196135533465e-06 NA NA NA hsa-miR-30e-5p PIK3CD -0.627815042856657 3.02205690184908e-10 -0.877858532886072 2.39332269929579e-06 MirTarget -0.253648851782905 0.00528999528593308 NA NA NA hsa-miR-616-5p PIK3CD 0.150569904638223 0.402836556304524 -0.877858532886072 2.39332269929579e-06 MirTarget -0.206581353665342 5.02538338243613e-05 NA NA NA hsa-miR-103a-3p PIK3R1 0.765568928457606 3.05497476509383e-12 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.187692597616198 0.00702590214654354 NA NA NA hsa-miR-106b-5p PIK3R1 0.648901865047099 8.24870862047885e-09 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.369244291882445 4.59379549667075e-08 NA NA NA hsa-miR-1301-3p PIK3R1 1.12156714169769 4.22404125385203e-10 -0.891953424131491 1.38465728969785e-08 MirTarget -0.26088137729301 3.97606431390706e-10 NA NA NA hsa-miR-132-3p PIK3R1 0.323796239695997 0.00272093067935091 -0.891953424131491 1.38465728969785e-08 MirTarget -0.517351445825174 2.17222827385203e-13 NA NA NA hsa-miR-17-5p PIK3R1 0.698861147045461 2.43854106455398e-05 -0.891953424131491 1.38465728969785e-08 MirTarget;TargetScan;miRNATAP -0.213954808771155 3.8587060059728e-06 NA NA NA hsa-miR-185-5p PIK3R1 0.480006257154717 6.35758891340152e-07 -0.891953424131491 1.38465728969785e-08 miRNATAP -0.255181123475439 0.00153792085091181 NA NA NA hsa-miR-188-5p PIK3R1 1.11646899351496 9.56686958408598e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.178093775716465 5.33015486626271e-05 NA NA NA hsa-miR-200c-3p PIK3R1 -0.104675615392797 0.716957669484981 -0.891953424131491 1.38465728969785e-08 mirMAP -0.105107802462856 9.06963579759966e-05 NA NA NA hsa-miR-20a-5p PIK3R1 0.854326758727003 5.04256669663285e-07 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.137431012149634 0.00237710222818209 NA NA NA hsa-miR-21-5p PIK3R1 1.51084295924322 1.54551622173259e-34 -0.891953424131491 1.38465728969785e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.626634426633867 6.01244523464713e-31 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 -0.288359631986802 0.100392159518997 -0.891953424131491 1.38465728969785e-08 MirTarget -0.258090192317157 3.95293509038579e-09 NA NA NA hsa-miR-221-3p PIK3R1 1.12244756358612 3.48370308238012e-13 -0.891953424131491 1.38465728969785e-08 MirTarget -0.217914846238424 7.87055620620445e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.08574156066353 1.76407192348131e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.256619417997498 3.41697791848384e-08 NA NA NA hsa-miR-324-3p PIK3R1 0.260348469146494 0.0506141704203545 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.281792149179102 1.26555231509763e-06 NA NA NA hsa-miR-330-3p PIK3R1 -0.332364259424489 0.0316051913061459 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.212492102885122 3.44445995574159e-05 NA NA NA hsa-miR-338-5p PIK3R1 -0.221898432884726 0.252390988727086 -0.891953424131491 1.38465728969785e-08 PITA -0.143685656767977 0.000366657184559181 NA NA NA hsa-miR-409-3p PIK3R1 -0.499649792570937 0.0526751181520117 -0.891953424131491 1.38465728969785e-08 mirMAP -0.110448878014769 0.000237041711390918 NA NA NA hsa-miR-493-5p PIK3R1 -0.198321662045422 0.502870277689198 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.103739426368655 7.76271840065789e-05 NA NA NA hsa-miR-582-5p PIK3R1 -0.680189083316822 0.00103755166534107 -0.891953424131491 1.38465728969785e-08 mirMAP -0.138461163257927 0.00021364752999012 NA NA NA hsa-miR-589-3p PIK3R1 1.16846704028095 5.88525574424201e-11 -0.891953424131491 1.38465728969785e-08 mirMAP -0.21021578613876 1.13421126603334e-06 NA NA NA hsa-miR-590-5p PIK3R1 -0.103355559980404 0.310027295317092 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRanda;miRNATAP -0.299776876388425 9.9413226282672e-05 NA NA NA hsa-miR-629-3p PIK3R1 -0.315338123880353 0.119091248294946 -0.891953424131491 1.38465728969785e-08 MirTarget -0.182940394280375 3.19896248240917e-06 NA NA NA hsa-miR-93-5p PIK3R1 1.39518349670953 2.84167728726712e-25 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.319783065556515 2.89613370212511e-09 NA NA NA hsa-miR-126-3p PIK3R2 -0.652349350198172 9.37876280344772e-09 0.902461657566753 1.95242785807378e-14 miRNAWalker2_validate;miRTarBase -0.307009584408785 1.4469316595199e-09 25240815;26384552;27578985;21249429;26191164 MiR 126 3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2; LRP6 and PIK3R2 were identified as targets of miR-126-3p; Silencing LRP6 and PIK3R2 had similar effects of miR-126-3p restoration on metastasis and angiogenesis individually in HCC cells; Furthermore the miR-126-3p level was inversely correlated with LRP6 and PIK3R2 in HCC tissues; In addition the rescue experiments indicated that the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2;MicroRNA 126 suppresses proliferation of undifferentiated BRAFV600E and BRAFWT thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K AKT proliferation survival signalling pathway; In addition miR-126 was found to act as proliferation suppressor targeting PIK3R2 gene and reducing p85β a regulatory subunit of PI3K kinase protein translation and lower AKT kinase activity;MiR 126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2 mediated PI3K/Akt signaling pathway; A direct regulatory relationship between miR-126 and the PIK3R2 gene was demonstrated by luciferase reporter assays; Quantitative real-time polymerase chain reaction was used to measure miR-126 and PIK3R2 expressions; Luciferase assays showed that miR-126 significantly inhibited the PIK3R2 3' untranslated region 3'UTR luciferase reporter activity P<0.05; Overexpression of miR-126 negatively regulated the target gene PIK3R2 and further inhibited the PI3K/Akt signaling pathway thereby inhibiting proliferation migration and invasion and promoting apoptosis in BLS cells;Endothelial specific intron derived miR 126 is down regulated in human breast cancer and targets both VEGFA and PIK3R2; VEGFA and PIK3R2 were confirmed as the targets of miR-126 by luciferase reporter assay and Western blot;Restoration of miR-126 in EC109 cells induced a reduction in PIK3R2 protein levels accompanied with a substantial reduction in phosphorylated AKT levels in EC109 cells suggesting impairment in PI3K/AKT signaling pathway; The luciferase reporter assay confirmed that PIK3R2 was a direct target of miR-126; Taken together our study suggests that miR-126 functions as a potential tumor suppressor in ESCC progression via regulating PI3K/AKT signaling pathway partly by targeting PIK3R2 and targeting of miR-126 may provide a novel strategy for the diagnosis and treatment of ESCC metastasis;poor survival;;;progression liver cancer;thyroid cancer;bladder cancer;breast cancer;esophageal cancer hsa-miR-28-5p PIK3R2 -0.430964830599964 2.67367257252925e-06 0.902461657566753 1.95242785807378e-14 miRanda -0.216513318430191 0.000794318920407844 NA NA NA hsa-miR-30a-5p PIK3R2 -0.626257932887855 0.000108198196973765 0.902461657566753 1.95242785807378e-14 miRNATAP -0.144672134574065 6.66511974688791e-05 NA NA NA hsa-miR-30e-5p PIK3R2 -0.627815042856657 3.02205690184908e-10 0.902461657566753 1.95242785807378e-14 miRNATAP -0.27051427660089 3.48529317139267e-06 NA NA NA hsa-miR-3607-3p PIK3R2 -2.15518588554493 1.03390728226728e-23 0.902461657566753 1.95242785807378e-14 mirMAP;miRNATAP -0.192639313478842 2.68262287342929e-14 NA NA NA hsa-miR-19a-3p PIK3R3 1.01712596153672 2.57753201450625e-07 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.104972668125809 0.000194207587349022 NA NA NA hsa-miR-19b-3p PIK3R3 0.601279551368824 0.00016685097085251 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.156884173334155 7.42851910353984e-06 NA NA NA hsa-miR-222-5p PIK3R3 0.125716360553359 0.487423909991138 0.635454203069077 2.81455381573105e-08 mirMAP -0.124074211713995 7.25281139850942e-05 NA NA NA hsa-miR-32-5p PIK3R3 0.0806126674664016 0.548984992497432 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.115094122727672 0.00654760226880116 NA NA NA hsa-miR-331-3p PIK3R3 -0.283974346994635 0.0373785411053202 0.635454203069077 2.81455381573105e-08 miRNAWalker2_validate;PITA -0.141431444954819 0.000659359723681179 NA NA NA hsa-miR-335-3p PIK3R3 -0.275199247483111 0.106629165248783 0.635454203069077 2.81455381573105e-08 mirMAP -0.159933987443154 1.18680673169693e-06 NA NA NA hsa-miR-454-3p PIK3R3 0.668749059573955 2.42670710515113e-06 0.635454203069077 2.81455381573105e-08 mirMAP -0.155284428603942 8.0835303918136e-05 NA NA NA hsa-miR-590-5p PIK3R3 -0.103355559980404 0.310027295317092 0.635454203069077 2.81455381573105e-08 miRanda -0.243402254613955 1.30668545381547e-05 NA NA NA hsa-miR-624-5p PIK3R3 -0.639533773668123 6.79146620944254e-06 0.635454203069077 2.81455381573105e-08 MirTarget -0.124942360560089 0.00156005977445166 NA NA NA hsa-miR-92a-3p PIK3R3 0.212391012518195 0.134292268089997 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.21036606255577 1.06004328001549e-07 NA NA NA hsa-miR-107 PIK3R5 0.241662461253461 0.0170788899505389 -0.89989526759384 1.62789758196776e-07 miRanda -0.349504238477674 3.20976138937126e-05 NA NA NA hsa-miR-106b-5p PPP3CA 0.648901865047099 8.24870862047885e-09 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.191067063648852 3.69747843513626e-08 NA NA NA hsa-miR-17-3p PPP3CA 0.410352776142368 0.00422200500748636 -0.536165287387848 2.77787023947662e-11 MirTarget -0.148715997251777 6.8452735631761e-08 NA NA NA hsa-miR-17-5p PPP3CA 0.698861147045461 2.43854106455398e-05 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.143640408234319 1.13035407609444e-09 NA NA NA hsa-miR-20a-5p PPP3CA 0.854326758727003 5.04256669663285e-07 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.13596145796804 2.84983869383186e-09 NA NA NA hsa-miR-21-5p PPP3CA 1.51084295924322 1.54551622173259e-34 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.143821297395015 1.2695170248385e-06 NA NA NA hsa-miR-30d-5p PPP3CA 0.718283816348023 2.47422074061352e-08 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.146138892286555 1.56191209956503e-06 NA NA NA hsa-miR-361-5p PPP3CA 0.233202959858696 0.00961572812255327 -0.536165287387848 2.77787023947662e-11 miRanda -0.145335005010698 0.00120607782460008 NA NA NA hsa-miR-501-3p PPP3CA 0.999540908940094 2.77358485581974e-11 -0.536165287387848 2.77787023947662e-11 MirTarget;PITA;miRNATAP -0.169069809996199 3.5765991379194e-11 NA NA NA hsa-miR-502-3p PPP3CA 0.659598854007546 3.01316453996423e-08 -0.536165287387848 2.77787023947662e-11 MirTarget;PITA;miRNATAP -0.21026132041502 1.15384439121552e-10 NA NA NA hsa-miR-589-3p PPP3CA 1.16846704028095 5.88525574424201e-11 -0.536165287387848 2.77787023947662e-11 MirTarget -0.121264895830011 4.18270966031286e-08 NA NA NA hsa-miR-93-3p PPP3CA 0.402821129107592 0.00131324842735588 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.143288165599429 6.27730698290466e-06 NA NA NA hsa-miR-93-5p PPP3CA 1.39518349670953 2.84167728726712e-25 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.206462809599041 4.19505348801646e-14 NA NA NA hsa-miR-361-5p PPP3CC 0.233202959858696 0.00961572812255327 -0.442598423475551 4.06646193924103e-07 miRanda -0.159719077024821 0.00091909551904825 NA NA NA hsa-miR-106b-5p PPP3R1 0.648901865047099 8.24870862047885e-09 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.138661227962938 5.82082557526804e-07 NA NA NA hsa-miR-181a-5p PPP3R1 0.250113435902954 0.0551933249319293 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.13691462952235 1.55708164198961e-08 NA NA NA hsa-miR-181b-5p PPP3R1 0.488256489401108 0.00105321129419701 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.13726473522507 5.36198845965272e-11 NA NA NA hsa-miR-181c-5p PPP3R1 -0.00639394152050299 0.969127212255928 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.116625763794141 9.00795108119744e-10 NA NA NA hsa-miR-24-3p PPP3R1 -0.257825594021966 0.00689742600215061 -0.348267739030591 8.30932335829799e-08 miRNAWalker2_validate -0.106343408108425 0.00160055709787487 NA NA NA hsa-miR-27a-3p PPP3R1 -0.370807380415112 0.00875721956202713 -0.348267739030591 8.30932335829799e-08 miRNATAP -0.117734120643401 1.31409589262749e-07 NA NA NA hsa-miR-93-5p PPP3R1 1.39518349670953 2.84167728726712e-25 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.108796059262154 9.63915967695639e-07 NA NA NA hsa-miR-15b-5p PRKACA 0.230566941413564 0.0824765001857479 -0.366734298281574 0.000187937709098459 miRNATAP -0.152941432259851 2.28347891457603e-05 NA NA NA hsa-miR-374b-3p PRKACA -0.137420230218985 0.305318192448799 -0.366734298281574 0.000187937709098459 mirMAP -0.12450872310223 0.000539430321626312 NA NA NA hsa-miR-744-5p PRKACA -0.378868377317939 0.00125071229180016 -0.366734298281574 0.000187937709098459 miRNAWalker2_validate -0.115884324772662 0.0046979329289167 NA NA NA hsa-miR-17-5p PRKACB 0.698861147045461 2.43854106455398e-05 -0.439902334736784 5.50105175875769e-05 TargetScan -0.144472658686219 5.56449338176546e-06 NA NA NA hsa-miR-193a-3p PRKACB -0.117675551589896 0.309391958208578 -0.439902334736784 5.50105175875769e-05 miRanda -0.138772633279135 0.00285551569786557 NA NA NA hsa-miR-19b-3p PRKACB 0.601279551368824 0.00016685097085251 -0.439902334736784 5.50105175875769e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.115986971473871 0.00048141723506022 NA NA NA hsa-miR-93-5p PRKACB 1.39518349670953 2.84167728726712e-25 -0.439902334736784 5.50105175875769e-05 miRNAWalker2_validate -0.135496406586043 0.000297518311204663 NA NA NA hsa-miR-155-5p PRKAR1A 0.0108524225071784 0.95651331033505 -0.221339462064076 0.0226218115406206 miRNAWalker2_validate -0.114318738366975 1.21359964338562e-06 NA NA NA hsa-miR-16-2-3p PRKAR1A -0.0336420826463706 0.805158952566973 -0.221339462064076 0.0226218115406206 mirMAP -0.132953751905959 0.00012681215248748 NA NA NA hsa-miR-324-3p PRKAR1A 0.260348469146494 0.0506141704203545 -0.221339462064076 0.0226218115406206 miRNAWalker2_validate -0.117454830748043 0.000948511276308163 NA NA NA hsa-miR-342-3p PRKAR1A -0.319677314984262 0.0449813878317147 -0.221339462064076 0.0226218115406206 miRanda -0.153816133332965 1.54784561086563e-07 NA NA NA hsa-miR-17-5p PRKAR2A 0.698861147045461 2.43854106455398e-05 -0.445956894636509 0.039701655854281 mirMAP -0.197176558926379 0.00184983862328776 NA NA NA hsa-miR-21-5p PRKAR2A 1.51084295924322 1.54551622173259e-34 -0.445956894636509 0.039701655854281 mirMAP -0.324627317167112 3.73345274692546e-05 NA NA NA hsa-miR-330-3p PRKAR2A -0.332364259424489 0.0316051913061459 -0.445956894636509 0.039701655854281 mirMAP -0.212639809934197 0.00237969257187532 NA NA NA hsa-miR-769-3p PRKAR2A 0.618139013155289 0.000147293288426878 -0.445956894636509 0.039701655854281 miRNAWalker2_validate -0.1775777282247 0.00738096929492439 NA NA NA hsa-miR-107 PRKAR2B 0.241662461253461 0.0170788899505389 -2.84864349816651 1.88295295481915e-25 miRanda -0.526935700945379 0.000176603848469258 NA NA NA hsa-miR-32-5p PRKAR2B 0.0806126674664016 0.548984992497432 -2.84864349816651 1.88295295481915e-25 miRNATAP -0.401821346272686 0.000140234241165594 NA NA NA hsa-miR-362-3p PRKAR2B 0.814007335895913 2.00108618836568e-09 -2.84864349816651 1.88295295481915e-25 miRanda -0.308186223710963 0.00269517694271484 NA NA NA hsa-miR-452-5p PRKAR2B 1.91544498799508 1.81995982853313e-14 -2.84864349816651 1.88295295481915e-25 miRNATAP -0.226491062848928 3.22037962571609e-05 NA NA NA hsa-miR-140-3p PRKX 0.546012239205329 4.84578261098777e-11 -0.240211607134995 0.240371070351319 mirMAP -0.414153706871003 0.000486275257531284 NA NA NA hsa-miR-148a-3p PRKX -0.748702855596996 3.93313343865641e-07 -0.240211607134995 0.240371070351319 MirTarget -0.590431480469924 2.08013051455884e-20 NA NA NA hsa-miR-16-1-3p PRKX 0.392360028038559 0.00112481918108198 -0.240211607134995 0.240371070351319 MirTarget -0.244568911489674 0.00313195084634789 NA NA NA hsa-miR-23b-3p PRKX -0.530561587109023 5.43807206823652e-07 -0.240211607134995 0.240371070351319 mirMAP -0.336626794798551 0.000311507204483922 NA NA NA hsa-miR-26b-3p PRKX -1.25503731613309 4.45390890119649e-27 -0.240211607134995 0.240371070351319 mirMAP -0.22275165341533 0.00569151212175373 NA NA NA hsa-miR-33a-5p PRKX -0.767474460958522 1.09948756118522e-05 -0.240211607134995 0.240371070351319 mirMAP -0.202109755439834 0.000339503602376678 NA NA NA hsa-miR-374a-3p PRKX -0.207171354826929 0.0623494608399903 -0.240211607134995 0.240371070351319 mirMAP -0.334277813432835 0.000202864124975447 NA NA NA hsa-miR-576-5p PRKX -0.377452008285847 0.00470735657343984 -0.240211607134995 0.240371070351319 mirMAP -0.216716249090268 0.00370148195253601 NA NA NA hsa-miR-107 TNF 0.241662461253461 0.0170788899505389 -1.0038697460391 4.57018472897375e-05 miRanda -0.319449999519582 0.00803039535673001 NA NA NA hsa-miR-361-5p TNF 0.233202959858696 0.00961572812255327 -1.0038697460391 4.57018472897375e-05 miRanda -0.383465948256239 0.00478262683574898 NA NA NA hsa-miR-17-5p TNFRSF10B 0.698861147045461 2.43854106455398e-05 -0.612825437825455 1.81500500305993e-08 miRNAWalker2_validate -0.118682318607652 0.000225544481104091 NA NA NA hsa-miR-339-5p TNFRSF10D 0.280589919878422 0.0355660282647215 -0.956031437203694 1.87959873199565e-08 miRanda -0.168123800997569 0.00796780173214136 NA NA NA hsa-let-7e-5p TNFRSF1A 0.0350298755544731 0.811068614727804 -0.779358458936897 4.22737006131824e-19 miRNAWalker2_validate -0.119647431964113 7.6612668803136e-05 NA NA NA hsa-miR-221-3p TNFSF10 1.12244756358612 3.48370308238012e-13 -0.719605061671142 5.12756319214624e-05 miRNAWalker2_validate;miRTarBase -0.279691652886283 2.76653565272805e-07 NA NA NA hsa-miR-222-3p TNFSF10 1.08574156066353 1.76407192348131e-11 -0.719605061671142 5.12756319214624e-05 miRNAWalker2_validate;miRTarBase -0.257653965579585 8.3406120984635e-07 NA NA NA hsa-miR-98-5p TNFSF10 -0.0487189107419432 0.715911066732548 -0.719605061671142 5.12756319214624e-05 miRNAWalker2_validate -0.189663077777932 0.0038160795260408 NA NA NA hsa-miR-122-5p TP53 -1.23907441373955 4.42181244888642e-06 -0.163823087975333 0.268013799235932 miRNATAP -0.104401376732605 6.76735273123785e-05 23221562;22235305 Loss of miR-122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1-modulated P53 activity.;Surprisingly miR-122 overexpression decreased the sensitivity to the chemotherapy-induced apoptosis via a signaling circuit involving the activation of Akt and inhibition of p53 ; liver cancer;lymphoma hsa-miR-25-3p TP53 0.633062563556379 3.68686354834328e-10 -0.163823087975333 0.268013799235932 miRNAWalker2_validate -0.198477612132015 0.00480268903724675 22431589 The results define miR-25 and -32 as positive regulators of p53 underscoring their role in tumorigenesis in glioblastoma tumorigenesis glioblastoma hsa-miR-320a TRADD 0.325285936317332 0.0221415065838824 0.267724124720407 0.0111863412981626 miRanda -0.174207497115951 1.21612763364167e-06 NA NA NA hsa-miR-106b-5p XIAP 0.648901865047099 8.24870862047885e-09 -0.15308594423064 0.0753030128680062 miRNATAP -0.125473079083479 0.000612516742455432 NA NA NA hsa-miR-140-3p XIAP 0.546012239205329 4.84578261098777e-11 -0.15308594423064 0.0753030128680062 mirMAP -0.139172884619669 0.0053077521694682 NA NA NA hsa-miR-16-1-3p XIAP 0.392360028038559 0.00112481918108198 -0.15308594423064 0.0753030128680062 mirMAP -0.104804633144744 0.00253046536387569 NA NA NA hsa-miR-17-5p XIAP 0.698861147045461 2.43854106455398e-05 -0.15308594423064 0.0753030128680062 miRNAWalker2_validate;TargetScan -0.160523036445281 6.000729723811e-11 NA NA NA hsa-miR-181a-5p XIAP 0.250113435902954 0.0551933249319293 -0.15308594423064 0.0753030128680062 miRNAWalker2_validate;miRTarBase;mirMAP -0.155528144427296 1.04965693208633e-06 NA NA NA hsa-miR-181b-5p XIAP 0.488256489401108 0.00105321129419701 -0.15308594423064 0.0753030128680062 miRNAWalker2_validate;miRTarBase;mirMAP -0.110373062475686 7.3789440913243e-05 NA NA NA hsa-miR-19b-1-5p XIAP -0.277804782598538 0.0783067794722916 -0.15308594423064 0.0753030128680062 MirTarget -0.148772325807858 1.26791111877443e-08 NA NA NA hsa-miR-19b-3p XIAP 0.601279551368824 0.00016685097085251 -0.15308594423064 0.0753030128680062 mirMAP -0.102901223661673 7.13974360361232e-05 NA NA NA hsa-miR-20a-5p XIAP 0.854326758727003 5.04256669663285e-07 -0.15308594423064 0.0753030128680062 miRNATAP -0.159439128688726 1.8964942127771e-11 NA NA NA hsa-miR-92a-3p XIAP 0.212391012518195 0.134292268089997 -0.15308594423064 0.0753030128680062 mirMAP -0.139311624854438 2.00037414590705e-06 NA NA NA