miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-29b-3p ABL1 0.438847962603729 6.46722433236121e-05 -0.275680169504946 1.26034737385624e-07 miRNATAP -0.150093657310066 4.97592840467e-21 NA NA NA hsa-miR-30e-5p ABL1 0.293491764699475 0.000372291967271834 -0.275680169504946 1.26034737385624e-07 MirTarget;miRNATAP -0.118450960397299 5.04005203445343e-08 NA NA NA hsa-miR-103a-3p ABL2 0.610673390034345 1.63113920514646e-12 0.212628644745099 0.000922122157083361 miRNAWalker2_validate;MirTarget;miRNATAP -0.167365388739268 2.1339564970491e-11 NA NA NA hsa-miR-140-3p ABL2 -1.25844395244141 5.29222651039892e-33 0.212628644745099 0.000922122157083361 miRNAWalker2_validate -0.117316563622328 4.47578343171796e-09 NA NA NA hsa-miR-26a-5p ABL2 -0.481180084102235 1.82368246174758e-10 0.212628644745099 0.000922122157083361 MirTarget;miRNATAP -0.142099787075603 9.33645881648894e-07 NA NA NA hsa-miR-29c-3p ABL2 -0.0652732378039769 0.563774115756922 0.212628644745099 0.000922122157083361 mirMAP -0.115993395232081 2.11711453461763e-09 NA NA NA hsa-miR-361-5p ABL2 -0.0996867547900457 0.095428250126326 0.212628644745099 0.000922122157083361 mirMAP -0.158704134799546 2.12461808045777e-05 NA NA NA hsa-miR-374a-5p ABL2 -0.239709888246804 0.00309819667153627 0.212628644745099 0.000922122157083361 mirMAP -0.125911676531627 3.7141946478882e-06 NA NA NA hsa-miR-625-3p ABL2 0.0779480073849017 0.444334811113011 0.212628644745099 0.000922122157083361 mirMAP -0.129151258679715 1.94505539339077e-09 NA NA NA hsa-miR-125b-5p AKT1 -1.94393269763542 2.78180543229264e-58 0.675644771423915 4.31393881321574e-23 miRNAWalker2_validate;miRTarBase -0.198341990959858 1.58124486218174e-28 NA NA NA hsa-miR-143-3p AKT1 -1.23248181631499 4.74160976678504e-28 0.675644771423915 4.31393881321574e-23 miRNAWalker2_validate -0.113351907486334 3.74647210660112e-08 NA NA NA hsa-miR-24-3p AKT2 -0.120123317289941 0.21432376743243 -0.0243409112523851 0.696831042278932 mirMAP -0.108581040434418 8.76204903485834e-07 NA NA NA hsa-miR-30e-3p AKT2 -0.708952170420973 1.05866470714978e-22 -0.0243409112523851 0.696831042278932 mirMAP -0.10769217628588 0.000202699653075448 NA NA NA hsa-miR-106b-5p AKT3 1.22477789913175 2.31787213143326e-32 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.328917679851073 3.2761525214021e-13 NA NA NA hsa-miR-107 AKT3 0.678998026350662 2.56224148930538e-16 -1.39153139819913 1.56022353185962e-23 PITA;miRanda -0.322045444014362 3.05085750718847e-08 NA NA NA hsa-miR-15a-5p AKT3 0.812445324157528 4.50263417099822e-20 -1.39153139819913 1.56022353185962e-23 miRNAWalker2_validate;miRTarBase;miRNATAP -0.50537113863267 1.94212195956378e-21 NA NA NA hsa-miR-15b-5p AKT3 0.788659356634696 1.13678211092534e-11 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.193152993862959 3.52162993117826e-06 NA NA NA hsa-miR-16-5p AKT3 0.46835991343556 1.91125356547776e-06 -1.39153139819913 1.56022353185962e-23 miRNAWalker2_validate;miRTarBase;miRNATAP -0.137142128931012 0.00593844300257035 NA NA NA hsa-miR-181a-5p AKT3 0.635863607630183 6.72486918157744e-11 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.151700435123375 0.00241569058552761 NA NA NA hsa-miR-181b-5p AKT3 1.22749257795094 1.21998198830919e-27 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.228362092376509 5.2632904676588e-08 NA NA NA hsa-miR-20a-5p AKT3 0.44979911120222 0.000602386964327228 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.142287905559561 0.000137185408492637 NA NA NA hsa-miR-29b-2-5p AKT3 -0.263499971180298 0.0400001755611965 -1.39153139819913 1.56022353185962e-23 mirMAP -0.174192327083419 4.9828909918003e-06 NA NA NA hsa-miR-29b-3p AKT3 0.438847962603729 6.46722433236121e-05 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.240095261108435 6.25012390753699e-08 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-29c-3p AKT3 -0.0652732378039769 0.563774115756922 -1.39153139819913 1.56022353185962e-23 miRNAWalker2_validate;miRNATAP -0.188130633733952 1.47230271027192e-05 NA NA NA hsa-miR-340-5p AKT3 1.0857159627596 4.94471062546756e-24 -1.39153139819913 1.56022353185962e-23 mirMAP -0.283834227072162 1.26866636163553e-10 NA NA NA hsa-miR-769-5p AKT3 0.564871766265874 8.16695101656941e-10 -1.39153139819913 1.56022353185962e-23 PITA;miRNATAP -0.188201328225218 0.000387633821142586 NA NA NA hsa-miR-93-5p AKT3 1.01788600209314 1.24312921618126e-21 -1.39153139819913 1.56022353185962e-23 miRNATAP -0.358774978428685 5.45504344144073e-16 NA NA NA hsa-miR-429 ANGPT1 2.84108892259147 3.88520896426515e-64 -3.16300498545581 8.56501022163231e-73 miRanda -0.493163485450717 1.16635414095955e-46 NA NA NA hsa-miR-590-3p ANGPT1 1.27438512890514 1.03164723481469e-23 -3.16300498545581 8.56501022163231e-73 PITA;miRanda;mirMAP -0.249579211964837 2.08892020158711e-06 NA NA NA hsa-miR-148a-5p ANGPT2 0.572692271754695 2.14306251522796e-06 -0.549211576203072 3.52083224037155e-07 mirMAP -0.103375715857729 0.000741562565982671 NA NA NA hsa-miR-19a-3p ANGPT2 0.817507952171848 3.76285090469625e-08 -0.549211576203072 3.52083224037155e-07 MirTarget -0.131690138905339 9.69188420190022e-08 NA NA NA hsa-miR-19b-3p ANGPT2 0.139124391010031 0.255658553872934 -0.549211576203072 3.52083224037155e-07 MirTarget -0.155260376407316 3.00137101828932e-07 NA NA NA hsa-miR-429 ANGPT2 2.84108892259147 3.88520896426515e-64 -0.549211576203072 3.52083224037155e-07 miRanda -0.156050420625197 1.27561726808804e-14 NA NA NA hsa-miR-664a-3p ANGPT2 -0.237699857923843 0.0197071390183375 -0.549211576203072 3.52083224037155e-07 mirMAP -0.10026929390526 0.00617721939067824 NA NA NA hsa-miR-218-5p ARF6 -1.02621788318234 2.9221925445771e-23 0.443995195392747 8.54065321182015e-16 MirTarget -0.104970079777398 5.59092422127586e-09 NA NA NA hsa-miR-28-3p ARF6 -0.815347900986328 3.29387468083828e-30 0.443995195392747 8.54065321182015e-16 MirTarget;PITA;miRNATAP -0.10697644647903 4.22073248269611e-05 NA NA NA hsa-miR-127-3p BAD -1.02337931491694 2.9749745518131e-15 0.671335929306102 6.05368129718844e-13 miRanda;miRNATAP -0.12231920555334 5.77371456889348e-07 NA NA NA hsa-miR-326 BAD -1.54449030848141 1.04703417845594e-17 0.671335929306102 6.05368129718844e-13 miRanda -0.162992963378128 2.73003852781454e-21 NA NA NA hsa-let-7c-5p BCL2L1 -1.9415540533505 9.55250745007793e-48 0.522792065960586 7.61639356485872e-19 miRNAWalker2_validate;miRTarBase -0.128294871675362 1.88688918547409e-19 20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA liver cancer hsa-let-7g-5p BCL2L1 0.0200025784917734 0.791635298815256 0.522792065960586 7.61639356485872e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.126630887025706 3.82717679314587e-06 20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA liver cancer hsa-let-7i-5p BCL2L1 -0.333419326258177 3.56960810786801e-08 0.522792065960586 7.61639356485872e-19 miRNATAP -0.321772345664847 8.06744439816135e-22 NA NA NA hsa-miR-140-5p BCL2L1 -0.755971041589807 9.68060922934542e-14 0.522792065960586 7.61639356485872e-19 PITA;miRanda;miRNATAP -0.178298678075701 1.10325405117987e-19 NA NA NA hsa-miR-505-5p BCL2L1 -0.842640534241897 4.43022473091907e-09 0.522792065960586 7.61639356485872e-19 miRNATAP -0.108734867438394 1.06030624737444e-14 NA NA NA hsa-miR-142-5p BDNF 1.16509303143593 1.96641162209073e-13 -1.60102244727579 3.13378744159785e-14 mirMAP -0.203218784089295 7.99082093515086e-06 NA NA NA hsa-miR-148a-5p BDNF 0.572692271754695 2.14306251522796e-06 -1.60102244727579 3.13378744159785e-14 mirMAP -0.397766884665729 3.21732972253681e-11 NA NA NA hsa-miR-155-5p BDNF 1.09766314984151 4.55650930885814e-15 -1.60102244727579 3.13378744159785e-14 miRNATAP -0.268404245015568 1.69880913103772e-07 NA NA NA hsa-miR-15a-5p BDNF 0.812445324157528 4.50263417099822e-20 -1.60102244727579 3.13378744159785e-14 MirTarget;miRNATAP -0.270462236614116 0.000896358870417413 26581909 MicroRNA 15a 5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF; BDNF was then overexpressed in HepG2 and SNU-182 cells to evaluate its selective effect on miR-15a-5p in HCC modulation; MiR-15a-5p selectively and negatively regulated BDNF at both gene and protein levels in HCC cells; Forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-15a-5p on HCC proliferation and cell division in vitro; Our study demonstrated that miR-15a-5p is a tumor suppressor in HCC and its regulation is through BDNF in HCC liver cancer hsa-miR-16-5p BDNF 0.46835991343556 1.91125356547776e-06 -1.60102244727579 3.13378744159785e-14 MirTarget;miRNATAP -0.207572734514068 0.0054038108129975 NA NA NA hsa-miR-182-5p BDNF 2.36408084103818 2.60011457600281e-72 -1.60102244727579 3.13378744159785e-14 MirTarget;miRNATAP -0.234588678348713 3.99165896393269e-06 NA NA NA hsa-miR-210-3p BDNF 2.38367203491819 3.73261999106754e-22 -1.60102244727579 3.13378744159785e-14 miRNAWalker2_validate;miRTarBase -0.115495455176462 6.58638340303894e-05 NA NA NA hsa-miR-30e-5p BDNF 0.293491764699475 0.000372291967271834 -1.60102244727579 3.13378744159785e-14 miRNATAP -0.400421315846613 7.13698491153316e-06 NA NA NA hsa-miR-589-3p BDNF 0.0263457630961427 0.866577983997705 -1.60102244727579 3.13378744159785e-14 MirTarget -0.125027718317622 0.00920347953748705 NA NA NA hsa-miR-589-5p BDNF 0.367182541239722 1.67804815542873e-05 -1.60102244727579 3.13378744159785e-14 miRNATAP -0.314299850428925 0.00026517944556323 NA NA NA hsa-miR-590-3p BDNF 1.27438512890514 1.03164723481469e-23 -1.60102244727579 3.13378744159785e-14 miRanda;mirMAP;miRNATAP -0.314287602443717 7.91546458232199e-08 NA NA NA hsa-miR-7-1-3p BDNF 0.686579567507582 1.20731554448806e-07 -1.60102244727579 3.13378744159785e-14 MirTarget -0.157643440663764 0.00510952033279118 NA NA NA hsa-let-7a-5p CALM1 -0.210286642041636 0.0072546234707717 -0.320900239255778 1.55423410834685e-08 TargetScan;miRNATAP -0.115611912509883 3.98437991996093e-06 NA NA NA hsa-miR-181c-5p CALM1 0.574847839298605 4.51287502066478e-07 -0.320900239255778 1.55423410834685e-08 miRNATAP -0.150249020962224 2.88169893193556e-19 NA NA NA hsa-miR-26a-5p CALM1 -0.481180084102235 1.82368246174758e-10 -0.320900239255778 1.55423410834685e-08 mirMAP -0.114178235236822 9.53983077786302e-06 NA NA NA hsa-miR-29a-3p CALM3 -0.699539666833076 1.13935003139957e-13 0.412506052330047 9.13012556554644e-14 miRNATAP -0.106730964380996 1.03461823560236e-07 NA NA NA hsa-miR-339-5p CALML3 -0.211548290465418 0.0685885445822389 -1.43016612621416 0.00026637059130134 miRanda -0.811680336835584 1.69009811501614e-12 NA NA NA hsa-miR-335-5p CALML5 -2.61355235628987 2.6462884165886e-51 1.22220772204633 0.00521721088309991 miRNAWalker2_validate -0.523338205356834 8.47288304296098e-11 NA NA NA hsa-miR-361-5p CDC42 -0.0996867547900457 0.095428250126326 0.173789856138974 9.56157991686127e-05 miRanda -0.123274419160974 1.83111084046675e-06 NA NA NA hsa-miR-15a-5p CHUK 0.812445324157528 4.50263417099822e-20 -0.0655383466936339 0.252025603609673 miRNAWalker2_validate;miRTarBase;MirTarget -0.135155500445723 3.1799004977298e-10 NA NA NA hsa-miR-106a-5p CSF1 0.574594373206545 0.000145868284001732 -1.08800144751585 6.47455154417147e-21 miRNATAP -0.112856920765228 2.52328970494851e-05 NA NA NA hsa-miR-106b-5p CSF1 1.22477789913175 2.31787213143326e-32 -1.08800144751585 6.47455154417147e-21 miRNATAP -0.309958906216993 9.90650672280216e-17 NA NA NA hsa-miR-107 CSF1 0.678998026350662 2.56224148930538e-16 -1.08800144751585 6.47455154417147e-21 miRanda -0.24596030061089 3.60923141846531e-07 NA NA NA hsa-miR-128-3p CSF1 0.90296715955238 9.925204823863e-23 -1.08800144751585 6.47455154417147e-21 MirTarget -0.194031179733804 6.9301013192568e-06 22909061 By mutations in putative miRNA targets in CSF-1 mRNA 3'UTR we identified a common target for both miR-128 and miR-152; We have also found that both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro two major aspects of the metastatic potential of cancer cells; Our results provide the evidence for a mechanism by which miR-128 and miR-152 down-regulate CSF-1 an important regulator of ovarian cancer motility ovarian cancer hsa-miR-130b-3p CSF1 1.38122163823846 1.00932179737836e-26 -1.08800144751585 6.47455154417147e-21 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.188326147995992 6.66850435979277e-10 22005523 CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system; CSF-1 expression was negatively associated with miR-130b level in ovarian tissues and cell lines; Luciferase assay validated CSF-1 is a direct target of miR-130b; Knock-down of CSF-1 sensitized ovarian cancer cells to anticancer drugs and could partially attenuate the resistance inducing effect of miR-130b inhibitors; Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1 and the silencing of miR-130b may be mediated by DNA methylation drug resistance ovarian cancer hsa-miR-148b-3p CSF1 1.0552576751879 1.6679285705231e-29 -1.08800144751585 6.47455154417147e-21 miRNAWalker2_validate -0.187041171487231 8.71634592486979e-06 NA NA NA hsa-miR-149-5p CSF1 0.218233101703391 0.261629158371175 -1.08800144751585 6.47455154417147e-21 MirTarget -0.144048188958803 3.45004343973706e-12 NA NA NA hsa-miR-15b-5p CSF1 0.788659356634696 1.13678211092534e-11 -1.08800144751585 6.47455154417147e-21 miRNATAP -0.117803030142251 0.00068024246553631 NA NA NA hsa-miR-17-5p CSF1 0.599531757298529 1.07318660415906e-05 -1.08800144751585 6.47455154417147e-21 TargetScan;miRNATAP -0.174864005974289 3.32952325826593e-09 NA NA NA hsa-miR-20a-5p CSF1 0.44979911120222 0.000602386964327228 -1.08800144751585 6.47455154417147e-21 miRNATAP -0.169006912067568 4.22612100145374e-08 NA NA NA hsa-miR-301a-3p CSF1 1.32170168375632 2.12280368957514e-15 -1.08800144751585 6.47455154417147e-21 MirTarget;miRNATAP -0.158253418441984 3.86536901326118e-11 NA NA NA hsa-miR-429 CSF1 2.84108892259147 3.88520896426515e-64 -1.08800144751585 6.47455154417147e-21 PITA;miRanda;miRNATAP -0.19084665356121 5.34746781839834e-18 NA NA NA hsa-miR-454-3p CSF1 1.28177672191095 6.84024979484587e-21 -1.08800144751585 6.47455154417147e-21 MirTarget;miRNATAP -0.171181789004693 3.84549274234278e-09 NA NA NA hsa-miR-93-5p CSF1 1.01788600209314 1.24312921618126e-21 -1.08800144751585 6.47455154417147e-21 miRNATAP -0.306827220898973 6.48739588242599e-17 NA NA NA hsa-miR-96-5p CSF1 3.24596558166606 1.92296159041707e-98 -1.08800144751585 6.47455154417147e-21 miRNATAP -0.252185993359345 1.25546616030164e-28 NA NA NA hsa-miR-218-5p EFNA1 -1.02621788318234 2.9221925445771e-23 1.03416794486437 5.98415403389838e-26 miRNAWalker2_validate -0.223154705444494 5.84928129078387e-12 NA NA NA hsa-miR-326 EFNA1 -1.54449030848141 1.04703417845594e-17 1.03416794486437 5.98415403389838e-26 miRanda -0.177390601452322 5.79220039722558e-22 NA NA NA hsa-miR-335-5p EFNA1 -2.61355235628987 2.6462884165886e-51 1.03416794486437 5.98415403389838e-26 miRNAWalker2_validate -0.128525356807881 4.72540778045499e-12 NA NA NA hsa-miR-486-5p EFNA1 -3.87258704301474 1.22658629378451e-80 1.03416794486437 5.98415403389838e-26 miRanda -0.133549219076437 7.71718683921977e-19 NA NA NA hsa-miR-491-5p EFNA1 -1.04307210952796 1.14586501470398e-15 1.03416794486437 5.98415403389838e-26 miRanda -0.113664637321473 1.57091587986049e-05 NA NA NA hsa-miR-145-5p EFNA3 -2.62703571936687 7.64402900188551e-88 1.58152606743336 5.43547499348979e-24 miRNATAP -0.225183758775436 1.30937642878182e-09 NA NA NA hsa-miR-30a-5p EFNA3 -0.392489994825279 0.00954894667761676 1.58152606743336 5.43547499348979e-24 MirTarget;mirMAP;miRNATAP -0.219092642537128 1.3512657859834e-09 NA NA NA hsa-miR-326 EFNA3 -1.54449030848141 1.04703417845594e-17 1.58152606743336 5.43547499348979e-24 MirTarget;miRanda;miRNATAP -0.147651472219488 7.90737227603787e-07 NA NA NA hsa-miR-486-5p EFNA3 -3.87258704301474 1.22658629378451e-80 1.58152606743336 5.43547499348979e-24 miRanda -0.24448323270154 9.12226705330056e-25 NA NA NA hsa-miR-140-5p EFNA4 -0.755971041589807 9.68060922934542e-14 1.36555460859862 9.20640991197574e-28 PITA;miRanda -0.167870909172277 9.74014850651836e-05 NA NA NA hsa-miR-182-5p EFNA5 2.36408084103818 2.60011457600281e-72 -1.37163072863579 4.49535560121869e-12 mirMAP;miRNATAP -0.345456013207985 2.56625510585803e-13 NA NA NA hsa-miR-200c-3p EFNA5 2.07038651806183 6.84613386286599e-51 -1.37163072863579 4.49535560121869e-12 miRNATAP -0.128934276846316 0.00592726380694451 NA NA NA hsa-miR-29c-3p EFNA5 -0.0652732378039769 0.563774115756922 -1.37163072863579 4.49535560121869e-12 miRNATAP -0.311367918739331 3.00972319771641e-07 NA NA NA hsa-miR-338-3p EFNA5 0.0799903526884966 0.575137668326679 -1.37163072863579 4.49535560121869e-12 miRanda;miRNATAP -0.249053958105886 2.18429568149124e-07 NA NA NA hsa-miR-342-3p EFNA5 1.21944481975657 6.81914373001202e-19 -1.37163072863579 4.49535560121869e-12 miRNATAP -0.345147728905934 1.06488395226997e-12 NA NA NA hsa-miR-7-1-3p EFNA5 0.686579567507582 1.20731554448806e-07 -1.37163072863579 4.49535560121869e-12 mirMAP -0.179610614381326 0.00065496480716735 NA NA NA hsa-miR-96-5p EFNA5 3.24596558166606 1.92296159041707e-98 -1.37163072863579 4.49535560121869e-12 TargetScan -0.238628836115784 1.35928421306458e-09 NA NA NA hsa-miR-590-3p EGF 1.27438512890514 1.03164723481469e-23 -1.56299913658955 5.86935289521553e-09 miRanda -0.381992230343087 2.5216093989528e-07 NA NA NA hsa-miR-629-3p EGF 1.25035919247365 3.91361135469024e-14 -1.56299913658955 5.86935289521553e-09 miRNATAP -0.198651351598521 0.000506937207678382 NA NA NA hsa-miR-107 EGFR 0.678998026350662 2.56224148930538e-16 -3.35228711557446 2.81857446737209e-45 miRanda -0.619981893208437 1.16509488926421e-09 NA NA NA hsa-miR-128-3p EGFR 0.90296715955238 9.925204823863e-23 -3.35228711557446 2.81857446737209e-45 miRNAWalker2_validate;miRTarBase -0.403877837900024 9.67805623106623e-06 NA NA NA hsa-miR-141-3p EGFR 2.99777540204168 1.26370498493024e-78 -3.35228711557446 2.81857446737209e-45 MirTarget -0.586858650420638 4.17631860777935e-36 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-141-5p EGFR 2.38411349683216 4.56310582620282e-58 -3.35228711557446 2.81857446737209e-45 MirTarget -0.540232230964423 7.07290618976338e-25 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-192-5p EGFR 1.33366224451777 9.5116159697107e-29 -3.35228711557446 2.81857446737209e-45 mirMAP -0.290600739714254 2.7733146554232e-05 NA NA NA hsa-miR-200a-3p EGFR 2.55218480823434 2.96135446816238e-51 -3.35228711557446 2.81857446737209e-45 MirTarget -0.529702964197266 2.19864859009139e-30 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-21-5p EGFR 2.32007501846389 3.08394781855554e-137 -3.35228711557446 2.81857446737209e-45 miRNAWalker2_validate;miRTarBase -0.671030468978973 2.34536849626451e-18 24198203;20113523;24012640;24331411;26563758;19597153;26026961;20048743 In radically resected NSCLC patients the expression levels of miR-21 10b in patients with EGFR mutation were much higher than those without mutation;Thus the miR-21 inhibitor might interrupt the activity of EGFR pathways independently of PTEN status;Further the expression of miR-21 is regulated by EGFR via the activation of β-catenin and AP-1; These data indicate that a feedback loop exists between miR-21 and EGFR; These results clarify a novel association between miR-21 and EGFR in the regulation of cancer cell progression;MiR 21 overexpression is associated with acquired resistance of EGFR TKI in non small cell lung cancer;Higher expression levels of miR-21 AmiR-27a and miR-218 detected in this study suggest potential roles of these miRNAs in primary resistance to EGFR-TKI in advanced NSCLC patients with EGFR exon 19 deletion mutations;MiR 21 is an EGFR regulated anti apoptotic factor in lung cancer in never smokers; The changes in expression of some of these miRNAs including miR-21 were more remarkable in cases with EGFR mutations than in those without these mutations; In the never-smoker-derived lung adenocarcinoma cell line H3255 with mutant EGFR and high levels of p-EGFR and miR-21 antisense inhibition of miR-21 enhanced AG1478-induced apoptosis; In a never-smoker-derived adenocarcinoma cell line H441 with wild-type EGFR the antisense miR-21 not only showed the additive effect with AG1478 but also induced apoptosis by itself; These results suggest that aberrantly increased expression of miR-21 which is enhanced further by the activated EGFR signaling pathway plays a significant role in lung carcinogenesis in never-smokers as well as in smokers and is a potential therapeutic target in both EGFR-mutant and wild-type cases;Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR mutated lung cancer via nickel induced microRNA 21 expression;Downregulation of miR 21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status ;;progression;drug resistance;staging;drug resistance;tumorigenesis;; lung squamous cell cancer;glioblastoma;glioblastoma;lung squamous cell cancer;lung squamous cell cancer;lung cancer;lung cancer;glioblastoma hsa-miR-29b-2-5p EGFR -0.263499971180298 0.0400001755611965 -3.35228711557446 2.81857446737209e-45 mirMAP -0.64036074154032 1.49079407610376e-22 NA NA NA hsa-miR-30a-5p EGFR -0.392489994825279 0.00954894667761676 -3.35228711557446 2.81857446737209e-45 miRNAWalker2_validate -0.182034532010776 0.0013553693971936 NA NA NA hsa-miR-340-5p EGFR 1.0857159627596 4.94471062546756e-24 -3.35228711557446 2.81857446737209e-45 mirMAP -0.347908635889104 8.12198670456393e-06 NA NA NA hsa-miR-342-3p EGFR 1.21944481975657 6.81914373001202e-19 -3.35228711557446 2.81857446737209e-45 miRanda -0.737335841516313 4.52090989396721e-36 NA NA NA hsa-miR-375 EGFR 2.09893673049766 1.68351780396203e-16 -3.35228711557446 2.81857446737209e-45 miRanda -0.424868499428666 2.03176717536657e-41 NA NA NA hsa-miR-3913-5p EGFR 0.71890413546147 2.61153227160465e-13 -3.35228711557446 2.81857446737209e-45 mirMAP -0.573576131982504 2.54015647019285e-11 NA NA NA hsa-miR-590-3p EGFR 1.27438512890514 1.03164723481469e-23 -3.35228711557446 2.81857446737209e-45 mirMAP -0.178661531450736 0.00972280347923564 NA NA NA hsa-miR-7-1-3p EGFR 0.686579567507582 1.20731554448806e-07 -3.35228711557446 2.81857446737209e-45 mirMAP -0.355654663689424 5.93286075856605e-08 NA NA NA hsa-miR-769-5p EGFR 0.564871766265874 8.16695101656941e-10 -3.35228711557446 2.81857446737209e-45 mirMAP -0.281258757298563 0.00254804504969195 NA NA NA hsa-miR-141-3p EPHA2 2.99777540204168 1.26370498493024e-78 -1.25921912819417 1.34618358519816e-29 MirTarget;TargetScan;miRNATAP -0.184299260927489 6.45342555838155e-17 24647573 miR 141 is a key regulator of renal cell carcinoma proliferation and metastasis by controlling EphA2 expression; In addition a specific and inverse correlation between miR-141 and EphA2 expression was obtained in human ccRCC samples metastasis kidney renal cell cancer hsa-miR-16-5p EPHA2 0.46835991343556 1.91125356547776e-06 -1.25921912819417 1.34618358519816e-29 miRNAWalker2_validate -0.176298379806946 1.09345046915033e-05 NA NA NA hsa-miR-193b-3p EPHA2 -0.0550374855074773 0.65382485898551 -1.25921912819417 1.34618358519816e-29 miRNAWalker2_validate -0.137802930852288 1.94517184204738e-05 NA NA NA hsa-miR-200a-3p EPHA2 2.55218480823434 2.96135446816238e-51 -1.25921912819417 1.34618358519816e-29 MirTarget;miRNATAP -0.119330959159105 5.02146466331342e-08 22562546;26088362;24503464 Our studies propose EphA2 as a novel and important target gene for miR-200a;miR 200a inhibits migration of triple negative breast cancer cells through direct repression of the EPHA2 oncogene; We show that EPHA2 expression is correlated with poor survival specifically in basal-like breast cancer and that its expression is repressed by miR-200a through direct interaction with the 3'UTR of EPHA2; We establish that miR-200a directs cell migration in a dual manner; in addition to regulating the well-characterized E-cadherin pathway it also regulates a EPHA2 pathway;In addition our results suggested that miR-200a inhibited VM by negatively regulated EphA2 expression; Consistently the inverse correlation of miR-200a and EphA2 has also been found in ovarian cancer patients; Our research demonstrates that VM miR-200a and EphA2 play key roles in the progression and prognosis of ovarian cancer and for the first time suggests that miR-200a inhibits VM by directly regulating EphA2 ;poor survival;cell migration;progression;worse prognosis breast cancer;breast cancer;ovarian cancer hsa-miR-1180-3p ETS1 0.678524139766789 6.97871971643379e-07 -0.979239394867202 3.4732433286646e-20 MirTarget -0.210942045646459 2.99390219889895e-15 NA NA NA hsa-miR-141-3p ETS1 2.99777540204168 1.26370498493024e-78 -0.979239394867202 3.4732433286646e-20 mirMAP -0.257236667059387 5.62368490791621e-37 NA NA NA hsa-miR-141-5p ETS1 2.38411349683216 4.56310582620282e-58 -0.979239394867202 3.4732433286646e-20 mirMAP -0.223127557221863 1.28606390051647e-22 NA NA NA hsa-miR-16-1-3p ETS1 1.30142784811196 2.53343713753744e-29 -0.979239394867202 3.4732433286646e-20 MirTarget -0.166775714600258 3.91778018167842e-07 NA NA NA hsa-miR-181a-5p ETS1 0.635863607630183 6.72486918157744e-11 -0.979239394867202 3.4732433286646e-20 MirTarget;miRNATAP -0.117397671747469 0.00202774382491482 NA NA NA hsa-miR-181b-5p ETS1 1.22749257795094 1.21998198830919e-27 -0.979239394867202 3.4732433286646e-20 MirTarget;miRNATAP -0.144411985174598 6.44545464062645e-06 NA NA NA hsa-miR-181c-5p ETS1 0.574847839298605 4.51287502066478e-07 -0.979239394867202 3.4732433286646e-20 MirTarget;miRNATAP -0.180665017669129 2.52511226528167e-08 NA NA NA hsa-miR-181d-5p ETS1 0.782618466877349 1.2821116358212e-09 -0.979239394867202 3.4732433286646e-20 MirTarget -0.196125864177591 4.83379268530988e-12 NA NA NA hsa-miR-193a-3p ETS1 0.310617999804917 0.00477640270974957 -0.979239394867202 3.4732433286646e-20 miRanda;miRNATAP -0.121714632973544 0.000333700676127298 NA NA NA hsa-miR-200a-3p ETS1 2.55218480823434 2.96135446816238e-51 -0.979239394867202 3.4732433286646e-20 mirMAP -0.226721918614687 1.27144828161341e-29 NA NA NA hsa-miR-200b-3p ETS1 2.11744072703209 1.66710572104191e-43 -0.979239394867202 3.4732433286646e-20 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.246496070854348 2.76376768290262e-28 NA NA NA hsa-miR-200c-3p ETS1 2.07038651806183 6.84613386286599e-51 -0.979239394867202 3.4732433286646e-20 MirTarget;miRNATAP -0.270324149960465 3.94762137659199e-28 NA NA NA hsa-miR-30c-5p ETS1 -0.393222674580066 8.06961465717306e-05 -0.979239394867202 3.4732433286646e-20 miRNAWalker2_validate -0.110579934710255 0.00315034205467605 NA NA NA hsa-miR-30d-3p ETS1 0.264544633563642 0.00755023189129747 -0.979239394867202 3.4732433286646e-20 mirMAP -0.189575366457993 4.81118769772035e-07 NA NA NA hsa-miR-338-3p ETS1 0.0799903526884966 0.575137668326679 -0.979239394867202 3.4732433286646e-20 MirTarget;PITA;miRanda;miRNATAP -0.151912917762978 5.1580518772831e-09 NA NA NA hsa-miR-429 ETS1 2.84108892259147 3.88520896426515e-64 -0.979239394867202 3.4732433286646e-20 MirTarget;PITA;miRanda;miRNATAP -0.22461293513372 1.79940772021513e-29 NA NA NA hsa-miR-664a-3p ETS1 -0.237699857923843 0.0197071390183375 -0.979239394867202 3.4732433286646e-20 mirMAP -0.193434208941414 1.19445852808372e-07 NA NA NA hsa-miR-769-5p ETS1 0.564871766265874 8.16695101656941e-10 -0.979239394867202 3.4732433286646e-20 miRNATAP -0.115705242047593 0.00418763798272212 NA NA NA hsa-miR-149-5p ETS2 0.218233101703391 0.261629158371175 -1.31204961264283 1.86414767606317e-43 miRNAWalker2_validate -0.129388772682219 1.08482544988607e-13 NA NA NA hsa-miR-182-5p ETS2 2.36408084103818 2.60011457600281e-72 -1.31204961264283 1.86414767606317e-43 miRNATAP -0.27739516846608 1.05140895247181e-33 NA NA NA hsa-miR-200b-3p ETS2 2.11744072703209 1.66710572104191e-43 -1.31204961264283 1.86414767606317e-43 TargetScan -0.208203339435452 7.43124017252109e-24 NA NA NA hsa-miR-429 ETS2 2.84108892259147 3.88520896426515e-64 -1.31204961264283 1.86414767606317e-43 PITA;miRanda;miRNATAP -0.192318327414313 1.62138039028248e-25 NA NA NA hsa-miR-590-3p ETS2 1.27438512890514 1.03164723481469e-23 -1.31204961264283 1.86414767606317e-43 miRanda -0.111680205497953 4.76055959127687e-05 NA NA NA hsa-miR-155-5p EXOC2 1.09766314984151 4.55650930885814e-15 0.400203425966282 8.51889887472945e-05 miRNAWalker2_validate -0.112077079200341 4.82756876106019e-06 NA NA NA hsa-miR-181c-5p EXOC2 0.574847839298605 4.51287502066478e-07 0.400203425966282 8.51889887472945e-05 MirTarget -0.101332395547096 0.000925885873458583 NA NA NA hsa-miR-181d-5p EXOC2 0.782618466877349 1.2821116358212e-09 0.400203425966282 8.51889887472945e-05 MirTarget -0.101944255222155 0.000149306919664622 NA NA NA hsa-miR-214-3p EXOC2 -0.523705501275844 0.000211299789901139 0.400203425966282 8.51889887472945e-05 MirTarget -0.108575327354845 1.18212048953936e-05 NA NA NA hsa-miR-455-5p EXOC2 0.284641224662773 0.0357572339594277 0.400203425966282 8.51889887472945e-05 miRanda -0.218336290162065 7.61768774254235e-18 NA NA NA hsa-let-7a-5p FASLG -0.210286642041636 0.0072546234707717 0.202786291597416 0.303256769370056 TargetScan;miRNATAP -0.254557236142898 0.0033640838487851 NA NA NA hsa-let-7b-5p FASLG -0.54215483448257 7.21347617597858e-08 0.202786291597416 0.303256769370056 miRNATAP -0.244673453612857 0.000244706869361269 NA NA NA hsa-let-7e-5p FASLG 0.261471269338985 0.00191077095550257 0.202786291597416 0.303256769370056 miRNATAP -0.337100053640702 2.69864596660333e-05 NA NA NA hsa-miR-16-1-3p FGF1 1.30142784811196 2.53343713753744e-29 -2.3363200609921 2.42261900591497e-58 mirMAP -0.581904531746624 8.04220781640102e-38 NA NA NA hsa-miR-186-5p FGF1 -0.426987301460247 1.04129380549315e-05 -2.3363200609921 2.42261900591497e-58 mirMAP -0.143723594837616 0.00933754138773196 NA NA NA hsa-miR-18a-5p FGF1 0.969066793715868 1.69069796425892e-08 -2.3363200609921 2.42261900591497e-58 MirTarget -0.308725947141596 9.70167258927243e-25 NA NA NA hsa-miR-193a-3p FGF1 0.310617999804917 0.00477640270974957 -2.3363200609921 2.42261900591497e-58 PITA -0.19690022881916 5.07868444768763e-05 NA NA NA hsa-miR-21-5p FGF1 2.32007501846389 3.08394781855554e-137 -2.3363200609921 2.42261900591497e-58 MirTarget -0.371477796734357 9.2806521720649e-15 NA NA NA hsa-miR-29a-5p FGF1 0.334183773952055 0.00445137265870197 -2.3363200609921 2.42261900591497e-58 mirMAP -0.152220555461099 0.000862510868875038 NA NA NA hsa-miR-320b FGF1 0.412787504747938 0.00113457276903985 -2.3363200609921 2.42261900591497e-58 miRanda -0.230047658868655 4.79239651855213e-08 NA NA NA hsa-miR-330-5p FGF1 0.626063225953928 3.42215028606779e-09 -2.3363200609921 2.42261900591497e-58 miRanda;miRNATAP -0.320213335163115 1.22351851936422e-10 NA NA NA hsa-miR-361-5p FGF1 -0.0996867547900457 0.095428250126326 -2.3363200609921 2.42261900591497e-58 miRanda -0.324186160458905 0.000365896398010837 NA NA NA hsa-miR-3913-5p FGF1 0.71890413546147 2.61153227160465e-13 -2.3363200609921 2.42261900591497e-58 mirMAP -0.147478952504203 0.00632555140399931 NA NA NA hsa-miR-429 FGF1 2.84108892259147 3.88520896426515e-64 -2.3363200609921 2.42261900591497e-58 miRNATAP -0.325212393355327 4.60753740095485e-30 NA NA NA hsa-miR-484 FGF1 0.349444060004737 0.00154491249625173 -2.3363200609921 2.42261900591497e-58 MirTarget;PITA;miRNATAP -0.350837387269644 2.42230585979755e-13 NA NA NA hsa-miR-532-3p FGF1 -0.395473145042459 0.00686714288452761 -2.3363200609921 2.42261900591497e-58 miRNATAP -0.135400728049064 0.000208318514603032 NA NA NA hsa-miR-550a-5p FGF1 -0.12364998419382 0.410467966112492 -2.3363200609921 2.42261900591497e-58 MirTarget -0.124015992653408 0.000650072833531158 NA NA NA hsa-miR-576-5p FGF1 0.0649387707567879 0.588791966096287 -2.3363200609921 2.42261900591497e-58 PITA;mirMAP -0.195551405525261 1.13745464101402e-05 NA NA NA hsa-miR-590-5p FGF1 0.746515607868274 8.51300479640125e-09 -2.3363200609921 2.42261900591497e-58 MirTarget;miRanda;miRNATAP -0.370669749508457 2.36068553671594e-20 NA NA NA hsa-miR-625-5p FGF1 0.728939236913178 5.97591217674307e-08 -2.3363200609921 2.42261900591497e-58 MirTarget -0.241254403404484 2.5870605302491e-09 NA NA NA hsa-miR-629-5p FGF1 0.42411327890895 2.46262300605706e-05 -2.3363200609921 2.42261900591497e-58 MirTarget -0.28293563961806 8.96106894697866e-08 NA NA NA hsa-miR-200b-3p FGF10 2.11744072703209 1.66710572104191e-43 -3.32771291998068 2.19492306477012e-23 TargetScan -0.477562798964516 3.55044319062017e-11 NA NA NA hsa-let-7a-5p FGF11 -0.210286642041636 0.0072546234707717 -0.654203699022933 6.56875051109305e-06 TargetScan;mirMAP;miRNATAP -0.267012754520769 3.15077825833402e-05 NA NA NA hsa-let-7b-5p FGF11 -0.54215483448257 7.21347617597858e-08 -0.654203699022933 6.56875051109305e-06 mirMAP;miRNATAP -0.138105904475298 0.00527683385622591 NA NA NA hsa-miR-331-3p FGF11 0.74441480542886 1.17071235477799e-07 -0.654203699022933 6.56875051109305e-06 miRNATAP -0.11808385160736 0.000829591224831171 NA NA NA hsa-miR-142-5p FGF12 1.16509303143593 1.96641162209073e-13 -0.643446523257955 0.000892623765099953 miRNATAP -0.125050416843925 0.00249966609947065 NA NA NA hsa-miR-17-5p FGF12 0.599531757298529 1.07318660415906e-05 -0.643446523257955 0.000892623765099953 TargetScan -0.150807716699532 0.00194136781001414 NA NA NA hsa-miR-200b-3p FGF12 2.11744072703209 1.66710572104191e-43 -0.643446523257955 0.000892623765099953 TargetScan -0.165329959072644 5.71604844896826e-05 NA NA NA hsa-miR-429 FGF12 2.84108892259147 3.88520896426515e-64 -0.643446523257955 0.000892623765099953 miRNATAP -0.122602237479307 0.000847169715536382 NA NA NA hsa-miR-455-5p FGF12 0.284641224662773 0.0357572339594277 -0.643446523257955 0.000892623765099953 miRanda -0.362285996207897 7.81172946390217e-14 NA NA NA hsa-miR-542-3p FGF12 0.568822103820889 8.5699075257651e-07 -0.643446523257955 0.000892623765099953 miRanda -0.186594268922009 0.00113571395430377 NA NA NA hsa-miR-141-3p FGF13 2.99777540204168 1.26370498493024e-78 -0.873614793965912 3.10323995957847e-07 TargetScan -0.151235108253828 5.55097538879746e-06 NA NA NA hsa-miR-142-5p FGF13 1.16509303143593 1.96641162209073e-13 -0.873614793965912 3.10323995957847e-07 PITA -0.171463579066746 2.60043790328601e-06 NA NA NA hsa-miR-200a-5p FGF13 2.58844508672328 1.79650654234569e-56 -0.873614793965912 3.10323995957847e-07 MirTarget;miRNATAP -0.144569347995968 1.56153098119586e-05 NA NA NA hsa-miR-590-3p FGF13 1.27438512890514 1.03164723481469e-23 -0.873614793965912 3.10323995957847e-07 miRanda -0.139748708534672 0.00308905149188458 NA NA NA hsa-miR-590-3p FGF14 1.27438512890514 1.03164723481469e-23 -0.743601748556524 2.04913944157729e-05 miRanda -0.437013841225084 1.73317372660872e-20 NA NA NA hsa-miR-96-5p FGF14 3.24596558166606 1.92296159041707e-98 -0.743601748556524 2.04913944157729e-05 TargetScan -0.186868577790991 5.83679167463715e-08 NA NA NA hsa-miR-15b-5p FGF18 0.788659356634696 1.13678211092534e-11 0.356025539172725 0.0347430848266563 miRNATAP -0.278632009163133 1.22698938766975e-08 NA NA NA hsa-miR-16-5p FGF18 0.46835991343556 1.91125356547776e-06 0.356025539172725 0.0347430848266563 miRNATAP -0.407440682812312 2.18411630304885e-12 NA NA NA hsa-miR-200b-3p FGF18 2.11744072703209 1.66710572104191e-43 0.356025539172725 0.0347430848266563 TargetScan -0.225608292610904 1.9483944408265e-10 NA NA NA hsa-miR-200c-3p FGF18 2.07038651806183 6.84613386286599e-51 0.356025539172725 0.0347430848266563 miRNATAP -0.297918294437242 1.5236208240269e-14 NA NA NA hsa-miR-326 FGF18 -1.54449030848141 1.04703417845594e-17 0.356025539172725 0.0347430848266563 PITA;miRanda;miRNATAP -0.120554064884584 0.000122916185329087 NA NA NA hsa-miR-330-5p FGF18 0.626063225953928 3.42215028606779e-09 0.356025539172725 0.0347430848266563 PITA;miRanda;miRNATAP -0.264450945601235 9.7958776270154e-07 NA NA NA hsa-miR-362-5p FGF18 -0.248676340901797 0.0726089851456282 0.356025539172725 0.0347430848266563 miRNATAP -0.160150519329221 0.000123017502928388 NA NA NA hsa-miR-424-5p FGF18 0.420789584199235 0.00480101660479489 0.356025539172725 0.0347430848266563 miRNATAP -0.118258719392065 0.00224759503637084 NA NA NA hsa-miR-429 FGF18 2.84108892259147 3.88520896426515e-64 0.356025539172725 0.0347430848266563 miRNATAP -0.192282799804847 1.28904804259296e-09 NA NA NA hsa-miR-505-3p FGF18 -0.530462599544864 7.71645736541597e-05 0.356025539172725 0.0347430848266563 miRNATAP -0.37019252141977 1.51921477550048e-18 NA NA NA hsa-miR-590-5p FGF18 0.746515607868274 8.51300479640125e-09 0.356025539172725 0.0347430848266563 miRanda;miRNATAP -0.439643988772613 1.86198557821583e-24 NA NA NA hsa-miR-9-5p FGF18 0.734772328078424 0.00261982843636383 0.356025539172725 0.0347430848266563 miRNATAP -0.200718216328244 4.25037312625656e-18 NA NA NA hsa-let-7a-3p FGF2 0.466622567891891 3.70886257943079e-07 -3.62110997961421 1.11252046868458e-69 mirMAP -0.291818855316242 0.000475924803881402 NA NA NA hsa-let-7f-1-3p FGF2 0.37532726250321 0.00156021688753682 -3.62110997961421 1.11252046868458e-69 mirMAP -0.20077854516594 0.00221318919252559 NA NA NA hsa-miR-103a-3p FGF2 0.610673390034345 1.63113920514646e-12 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate;MirTarget;miRNATAP -0.723924551136195 6.60361690701997e-17 NA NA NA hsa-miR-107 FGF2 0.678998026350662 2.56224148930538e-16 -3.62110997961421 1.11252046868458e-69 MirTarget;PITA;miRanda;miRNATAP -0.796465331145451 7.23286562379616e-19 NA NA NA hsa-miR-142-3p FGF2 1.53951237846104 2.06769936282034e-17 -3.62110997961421 1.11252046868458e-69 miRanda -0.17283302588329 2.98031372863511e-05 NA NA NA hsa-miR-155-5p FGF2 1.09766314984151 4.55650930885814e-15 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate;mirMAP -0.14901722637598 0.00579079439331683 NA NA NA hsa-miR-15a-5p FGF2 0.812445324157528 4.50263417099822e-20 -3.62110997961421 1.11252046868458e-69 MirTarget;miRNATAP -0.693907136905669 1.18654679034038e-16 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 1.12898579025388 1.18050912917317e-14 -3.62110997961421 1.11252046868458e-69 mirMAP -0.416639852881488 2.41684465169063e-16 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 0.788659356634696 1.13678211092534e-11 -3.62110997961421 1.11252046868458e-69 MirTarget;miRNATAP -0.416542064799323 1.32439928134663e-10 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 1.30142784811196 2.53343713753744e-29 -3.62110997961421 1.11252046868458e-69 mirMAP -0.618895974599859 1.26519964172122e-20 NA NA NA hsa-miR-16-2-3p FGF2 0.286355254959005 0.0256946046884474 -3.62110997961421 1.11252046868458e-69 mirMAP -0.190718116559883 0.00155781442617599 NA NA NA hsa-miR-16-5p FGF2 0.46835991343556 1.91125356547776e-06 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate;MirTarget;miRNATAP -0.334764026766057 1.68868207410758e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-181a-5p FGF2 0.635863607630183 6.72486918157744e-11 -3.62110997961421 1.11252046868458e-69 mirMAP -0.445820481795785 9.84329484201549e-09 NA NA NA hsa-miR-181b-5p FGF2 1.22749257795094 1.21998198830919e-27 -3.62110997961421 1.11252046868458e-69 mirMAP -0.542719617785167 6.40042754935602e-17 NA NA NA hsa-miR-181c-5p FGF2 0.574847839298605 4.51287502066478e-07 -3.62110997961421 1.11252046868458e-69 mirMAP -0.226227363468224 0.00075162633624824 NA NA NA hsa-miR-192-5p FGF2 1.33366224451777 9.5116159697107e-29 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate -0.492571390734632 6.64406170620692e-16 NA NA NA hsa-miR-19b-1-5p FGF2 0.647704962003062 3.07687667945597e-07 -3.62110997961421 1.11252046868458e-69 mirMAP -0.220669191860133 0.000256708213140997 NA NA NA hsa-miR-200b-3p FGF2 2.11744072703209 1.66710572104191e-43 -3.62110997961421 1.11252046868458e-69 mirMAP -0.474105291344653 1.09246839719196e-24 NA NA NA hsa-miR-200c-3p FGF2 2.07038651806183 6.84613386286599e-51 -3.62110997961421 1.11252046868458e-69 mirMAP -0.615252170517975 1.40903756446366e-34 NA NA NA hsa-miR-21-3p FGF2 2.17476065946878 5.15299442583591e-75 -3.62110997961421 1.11252046868458e-69 mirMAP -0.712905950790447 1.55737305852276e-36 NA NA NA hsa-miR-21-5p FGF2 2.32007501846389 3.08394781855554e-137 -3.62110997961421 1.11252046868458e-69 mirMAP -1.0007316696677 9.45001605861665e-53 NA NA NA hsa-miR-32-5p FGF2 1.38676603945192 2.29428299685976e-34 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate -0.601478209606274 2.96886796474821e-21 NA NA NA hsa-miR-330-3p FGF2 0.432728362037032 0.00041335506960812 -3.62110997961421 1.11252046868458e-69 mirMAP -0.190108192654775 0.00276026518304351 NA NA NA hsa-miR-429 FGF2 2.84108892259147 3.88520896426515e-64 -3.62110997961421 1.11252046868458e-69 mirMAP -0.50658475327409 1.36690059845309e-35 NA NA NA hsa-miR-503-5p FGF2 1.89861508626371 8.64468509978193e-28 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate -0.318786957596351 2.28520886786229e-13 NA NA NA hsa-miR-590-3p FGF2 1.27438512890514 1.03164723481469e-23 -3.62110997961421 1.11252046868458e-69 miRanda;mirMAP -0.434908422832851 8.74942691621125e-13 NA NA NA hsa-miR-590-5p FGF2 0.746515607868274 8.51300479640125e-09 -3.62110997961421 1.11252046868458e-69 miRanda;mirMAP -0.340101326786598 5.86637073853323e-09 NA NA NA hsa-miR-93-3p FGF2 0.627759242044891 3.62527588304617e-06 -3.62110997961421 1.11252046868458e-69 mirMAP -0.374363069604572 2.04134280501924e-11 NA NA NA hsa-let-7a-3p FGF7 0.466622567891891 3.70886257943079e-07 -2.04584639946267 6.89325129361849e-43 MirTarget;miRNATAP -0.291554234913666 5.86497309861538e-07 NA NA NA hsa-miR-107 FGF7 0.678998026350662 2.56224148930538e-16 -2.04584639946267 6.89325129361849e-43 PITA;miRanda;miRNATAP -0.546294975137966 4.4731046654949e-18 NA NA NA hsa-miR-15a-5p FGF7 0.812445324157528 4.50263417099822e-20 -2.04584639946267 6.89325129361849e-43 miRTarBase;miRNATAP -0.531335245933583 1.07978052597967e-19 NA NA NA hsa-miR-15b-5p FGF7 0.788659356634696 1.13678211092534e-11 -2.04584639946267 6.89325129361849e-43 miRNATAP -0.294334950139095 9.5895878173005e-11 NA NA NA hsa-miR-16-1-3p FGF7 1.30142784811196 2.53343713753744e-29 -2.04584639946267 6.89325129361849e-43 mirMAP -0.437128601027858 6.61913037421969e-21 NA NA NA hsa-miR-16-2-3p FGF7 0.286355254959005 0.0256946046884474 -2.04584639946267 6.89325129361849e-43 mirMAP -0.225774074048836 7.90334438903079e-08 NA NA NA hsa-miR-16-5p FGF7 0.46835991343556 1.91125356547776e-06 -2.04584639946267 6.89325129361849e-43 miRNATAP -0.294993672554423 5.86741065196244e-08 NA NA NA hsa-miR-20a-5p FGF7 0.44979911120222 0.000602386964327228 -2.04584639946267 6.89325129361849e-43 miRNAWalker2_validate -0.243033729024757 2.41787962262626e-09 NA NA NA hsa-miR-30d-3p FGF7 0.264544633563642 0.00755023189129747 -2.04584639946267 6.89325129361849e-43 miRNATAP -0.316263621956414 5.48336610985585e-09 NA NA NA hsa-miR-320b FGF7 0.412787504747938 0.00113457276903985 -2.04584639946267 6.89325129361849e-43 miRanda -0.139459566850431 0.00108196556023217 NA NA NA hsa-miR-340-5p FGF7 1.0857159627596 4.94471062546756e-24 -2.04584639946267 6.89325129361849e-43 mirMAP -0.279133011350609 9.24446622871117e-09 NA NA NA hsa-miR-429 FGF7 2.84108892259147 3.88520896426515e-64 -2.04584639946267 6.89325129361849e-43 miRNATAP -0.366295181453287 6.14104708947163e-38 NA NA NA hsa-miR-484 FGF7 0.349444060004737 0.00154491249625173 -2.04584639946267 6.89325129361849e-43 PITA -0.168542958718501 0.000557416327492428 NA NA NA hsa-miR-590-3p FGF7 1.27438512890514 1.03164723481469e-23 -2.04584639946267 6.89325129361849e-43 PITA;miRanda;mirMAP;miRNATAP -0.299954971963049 2.12582339280064e-12 NA NA NA hsa-miR-590-5p FGF7 0.746515607868274 8.51300479640125e-09 -2.04584639946267 6.89325129361849e-43 PITA;miRanda -0.248349796532555 1.32069527646423e-09 NA NA NA hsa-miR-7-1-3p FGF7 0.686579567507582 1.20731554448806e-07 -2.04584639946267 6.89325129361849e-43 mirMAP -0.291915571429539 8.2244137316862e-13 NA NA NA hsa-miR-15a-5p FGF9 0.812445324157528 4.50263417099822e-20 -2.4852262043005 1.90052930236681e-24 miRNATAP -0.453532492537739 1.81189938850602e-06 NA NA NA hsa-miR-16-5p FGF9 0.46835991343556 1.91125356547776e-06 -2.4852262043005 1.90052930236681e-24 miRNATAP -0.265584515990919 0.00235373908707608 NA NA NA hsa-miR-181b-5p FGF9 1.22749257795094 1.21998198830919e-27 -2.4852262043005 1.90052930236681e-24 mirMAP -0.251706769659496 0.000662639171300449 NA NA NA hsa-miR-182-5p FGF9 2.36408084103818 2.60011457600281e-72 -2.4852262043005 1.90052930236681e-24 miRTarBase;miRNATAP -0.452581728187924 1.53870203091154e-14 NA NA NA hsa-miR-183-5p FGF9 2.95681814393872 1.09965777344285e-92 -2.4852262043005 1.90052930236681e-24 miRNATAP -0.421051105687966 5.55191507820402e-16 NA NA NA hsa-miR-429 FGF9 2.84108892259147 3.88520896426515e-64 -2.4852262043005 1.90052930236681e-24 miRanda -0.319482141660943 1.05794965240276e-11 NA NA NA hsa-miR-590-3p FGF9 1.27438512890514 1.03164723481469e-23 -2.4852262043005 1.90052930236681e-24 miRanda;mirMAP -0.208237924178229 0.00252074976910256 NA NA NA hsa-miR-96-5p FGF9 3.24596558166606 1.92296159041707e-98 -2.4852262043005 1.90052930236681e-24 TargetScan;miRNATAP -0.44484666162403 4.74837998245841e-20 NA NA NA hsa-miR-106a-5p FGFR1 0.574594373206545 0.000145868284001732 -1.14663914385064 6.08915041092458e-18 mirMAP -0.140764850201839 4.05395479162201e-06 NA NA NA hsa-miR-106b-5p FGFR1 1.22477789913175 2.31787213143326e-32 -1.14663914385064 6.08915041092458e-18 mirMAP -0.187712904592992 1.40602847883516e-05 NA NA NA hsa-miR-15a-5p FGFR1 0.812445324157528 4.50263417099822e-20 -1.14663914385064 6.08915041092458e-18 miRNATAP -0.158299254797074 0.00214218396058389 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGFR1 0.788659356634696 1.13678211092534e-11 -1.14663914385064 6.08915041092458e-18 miRNATAP -0.1205608912803 0.00233144736273568 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 0.46835991343556 1.91125356547776e-06 -1.14663914385064 6.08915041092458e-18 miRTarBase;miRNATAP -0.183714075820348 9.67034011184e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-200a-5p FGFR1 2.58844508672328 1.79650654234569e-56 -1.14663914385064 6.08915041092458e-18 mirMAP -0.215721842068481 1.13267932151434e-16 NA NA NA hsa-miR-200b-5p FGFR1 1.43091697052145 2.07975242866479e-22 -1.14663914385064 6.08915041092458e-18 mirMAP -0.16607698201377 1.28945935874685e-07 NA NA NA hsa-miR-20b-5p FGFR1 0.78236583455125 8.7938334801223e-05 -1.14663914385064 6.08915041092458e-18 mirMAP -0.115810849796481 5.3473776263928e-07 NA NA NA hsa-miR-301a-3p FGFR1 1.32170168375632 2.12280368957514e-15 -1.14663914385064 6.08915041092458e-18 mirMAP -0.10939487939016 7.18051162231598e-05 NA NA NA hsa-miR-330-3p FGFR1 0.432728362037032 0.00041335506960812 -1.14663914385064 6.08915041092458e-18 PITA;miRNATAP -0.10383346919971 0.00691823598065563 NA NA NA hsa-miR-330-5p FGFR1 0.626063225953928 3.42215028606779e-09 -1.14663914385064 6.08915041092458e-18 miRanda;miRNATAP -0.200093067000453 4.15731266944936e-06 NA NA NA hsa-miR-455-5p FGFR1 0.284641224662773 0.0357572339594277 -1.14663914385064 6.08915041092458e-18 miRanda -0.107782773565761 0.0016907871459656 NA NA NA hsa-miR-590-3p FGFR1 1.27438512890514 1.03164723481469e-23 -1.14663914385064 6.08915041092458e-18 miRanda;mirMAP -0.232790337775512 2.91176217126465e-10 NA NA NA hsa-miR-93-5p FGFR1 1.01788600209314 1.24312921618126e-21 -1.14663914385064 6.08915041092458e-18 mirMAP -0.155396198762809 0.000265353923933065 NA NA NA hsa-miR-107 FGFR2 0.678998026350662 2.56224148930538e-16 -0.775141603791194 2.04453402884716e-05 PITA;miRanda -0.355887284370132 1.72803357435902e-06 NA NA NA hsa-miR-193a-3p FGFR2 0.310617999804917 0.00477640270974957 -0.775141603791194 2.04453402884716e-05 miRanda -0.294573603452518 2.04016256999751e-07 NA NA NA hsa-miR-369-3p FGFR2 0.0880848299432269 0.48519534195924 -0.775141603791194 2.04453402884716e-05 miRNATAP -0.134882932202002 0.00703831397411665 NA NA NA hsa-miR-423-3p FGFR2 0.338351552541003 0.000947983901628776 -0.775141603791194 2.04453402884716e-05 PITA;miRNATAP -0.1727701841783 0.00483828495442655 NA NA NA hsa-miR-590-3p FGFR2 1.27438512890514 1.03164723481469e-23 -0.775141603791194 2.04453402884716e-05 miRanda -0.203907123628065 4.71460047941147e-05 NA NA NA hsa-miR-100-5p FGFR3 -1.89453309391092 5.00588682382388e-51 1.86754699235588 2.21866053477893e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.235261430958759 0.000205428105475304 25344675;26604796;26018508;23778527 MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3;Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress ;;;poor survival pancreatic cancer;glioblastoma;sarcoma;bladder cancer hsa-miR-142-3p FGFR3 1.53951237846104 2.06769936282034e-17 1.86754699235588 2.21866053477893e-14 miRanda -0.186690154425788 4.78356753122835e-05 NA NA NA hsa-miR-19a-3p FGFR3 0.817507952171848 3.76285090469625e-08 1.86754699235588 2.21866053477893e-14 mirMAP -0.197762599825557 0.000503996109696735 NA NA NA hsa-miR-19b-3p FGFR3 0.139124391010031 0.255658553872934 1.86754699235588 2.21866053477893e-14 mirMAP -0.298900555145995 1.74346769891144e-05 NA NA NA hsa-miR-24-3p FGFR3 -0.120123317289941 0.21432376743243 1.86754699235588 2.21866053477893e-14 MirTarget;miRNATAP -0.593260915828542 1.24772160110599e-11 NA NA NA hsa-miR-337-3p FGFR3 -2.14274617598363 2.70942896809734e-43 1.86754699235588 2.21866053477893e-14 MirTarget -0.276342803887382 8.88392937600617e-08 NA NA NA hsa-miR-455-3p FGFR3 0.678392920628872 0.000327758844555877 1.86754699235588 2.21866053477893e-14 PITA -0.311970748789501 2.16597532806041e-12 NA NA NA hsa-miR-532-5p FGFR3 0.0386976222860582 0.682018574136515 1.86754699235588 2.21866053477893e-14 mirMAP -0.285596505551977 0.00164247472635195 NA NA NA hsa-miR-99a-5p FGFR3 -2.25079447371102 1.14086813185885e-54 1.86754699235588 2.21866053477893e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.320837636799125 4.30235413296182e-09 23409016;24456664;23298836 Photofrin based photodynamic therapy and miR 99a transfection inhibited FGFR3 and PI3K/Akt signaling mechanisms to control growth of human glioblastoma In vitro and in vivo; Further photofrin based PDT followed by miR-99a transfection dramatically increased miR-99a expression and also increased apoptosis in glioblastoma cell cultures and drastically reduced tumor growth in athymic nude mice due to down regulation of fibroblast growth factor receptor 3 FGFR3 and PI3K/Akt signaling mechanisms leading to inhibition of cell proliferation and induction of molecular mechanisms of apoptosis;miR 99a promotes proliferation targeting FGFR3 in human epithelial ovarian cancer cells; Importantly fibroblast growth factor receptor 3 FGFR3 predicted to be one target gene of miR-99a using computational algorithms was higher in expression in EOC cells; Subsequently FGFR3 was proved to be direct target of miR-99a by dual luciferase assay; Furthermore overexpression of miR-99a dramatically suppressed expression level of FGFR3 at both mRNA and protein levels proving FGFR3 to be inversely correlated with miR-99a; Finally overexpression of miR-99a could significantly inhibit EOC cell proliferation in vitro by decreasing the expression of FGFR3 which also reduced the EOC cell growth after siRNA knockdown; Conclusively miR-99a expression was remarkably downregulated in serums tissues and cell and suppresses EOC cell proliferation by targeting FGFR3 suggesting miR-99a as a prospective prognosis marker and potential tumor suppressor for EOC therapeutics;The tumorigenic FGFR3 TACC3 gene fusion escapes miR 99a regulation in glioblastoma; The fusion caused by tandem duplication on 4p16.3 led to the loss of the 3'-UTR of FGFR3 blocking gene regulation of miR-99a and enhancing expression of the fusion gene ;worse prognosis; glioblastoma;ovarian cancer;glioblastoma hsa-miR-326 FGFR4 -1.54449030848141 1.04703417845594e-17 1.53418109992094 1.4752304353364e-09 miRanda;miRNATAP -0.170195226279497 0.000361551375916332 NA NA NA hsa-miR-491-5p FGFR4 -1.04307210952796 1.14586501470398e-15 1.53418109992094 1.4752304353364e-09 miRanda -0.298147283214882 7.57138894516634e-06 NA NA NA hsa-miR-106b-5p FLT1 1.22477789913175 2.31787213143326e-32 -0.976682151789582 4.79604479745106e-23 MirTarget;miRNATAP -0.268178565619622 3.8111441429214e-17 NA NA NA hsa-miR-107 FLT1 0.678998026350662 2.56224148930538e-16 -0.976682151789582 4.79604479745106e-23 miRanda -0.314938269682321 1.32029901450643e-14 NA NA NA hsa-miR-146b-5p FLT1 0.631041661167954 6.20366593452965e-08 -0.976682151789582 4.79604479745106e-23 miRanda -0.202091696389093 5.72871952887742e-12 NA NA NA hsa-miR-155-5p FLT1 1.09766314984151 4.55650930885814e-15 -0.976682151789582 4.79604479745106e-23 miRNAWalker2_validate;mirMAP -0.141999192123706 4.82181118961184e-09 NA NA NA hsa-miR-17-5p FLT1 0.599531757298529 1.07318660415906e-05 -0.976682151789582 4.79604479745106e-23 MirTarget;TargetScan;miRNATAP -0.16218378079303 1.23634449026838e-10 NA NA NA hsa-miR-181a-5p FLT1 0.635863607630183 6.72486918157744e-11 -0.976682151789582 4.79604479745106e-23 miRNATAP -0.219297738042611 4.37776931001255e-10 NA NA NA hsa-miR-181b-5p FLT1 1.22749257795094 1.21998198830919e-27 -0.976682151789582 4.79604479745106e-23 miRNATAP -0.222578263194722 4.64458789140547e-14 NA NA NA hsa-miR-181c-5p FLT1 0.574847839298605 4.51287502066478e-07 -0.976682151789582 4.79604479745106e-23 miRNATAP -0.239615399546846 1.17848772957282e-15 NA NA NA hsa-miR-19a-3p FLT1 0.817507952171848 3.76285090469625e-08 -0.976682151789582 4.79604479745106e-23 MirTarget -0.158919931608538 4.57034977071252e-12 NA NA NA hsa-miR-19b-3p FLT1 0.139124391010031 0.255658553872934 -0.976682151789582 4.79604479745106e-23 MirTarget -0.152764572510247 6.91840199554879e-08 NA NA NA hsa-miR-200b-3p FLT1 2.11744072703209 1.66710572104191e-43 -0.976682151789582 4.79604479745106e-23 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.237387253520266 3.06104626134544e-30 21115742 Forced miR-200 expression suppressed Flt1 levels in metastasis-prone lung adenocarcinoma cells derived from K-ras/p53-mutant mice and negatively regulated the Flt1 3'-UTR in reporter assays; We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1 metastasis;tumorigenesis lung cancer hsa-miR-200c-3p FLT1 2.07038651806183 6.84613386286599e-51 -0.976682151789582 4.79604479745106e-23 miRNAWalker2_validate;miRTarBase;MirTarget -0.255668357647663 5.50361375778068e-29 NA NA NA hsa-miR-20a-5p FLT1 0.44979911120222 0.000602386964327228 -0.976682151789582 4.79604479745106e-23 MirTarget;miRNATAP -0.233663438164218 2.1323989806554e-19 NA NA NA hsa-miR-361-5p FLT1 -0.0996867547900457 0.095428250126326 -0.976682151789582 4.79604479745106e-23 miRanda -0.281387154816715 1.81346924134673e-06 NA NA NA hsa-miR-429 FLT1 2.84108892259147 3.88520896426515e-64 -0.976682151789582 4.79604479745106e-23 MirTarget;miRanda;miRNATAP -0.212494365543953 2.16632813796484e-30 NA NA NA hsa-miR-590-3p FLT1 1.27438512890514 1.03164723481469e-23 -0.976682151789582 4.79604479745106e-23 miRanda -0.150457515693858 5.7105738196085e-08 NA NA NA hsa-miR-93-5p FLT1 1.01788600209314 1.24312921618126e-21 -0.976682151789582 4.79604479745106e-23 MirTarget;miRNATAP -0.305409002203918 9.83786412000852e-23 NA NA NA hsa-miR-590-3p FLT3 1.27438512890514 1.03164723481469e-23 0.668821394707615 0.0177967298375228 PITA;miRanda;mirMAP;miRNATAP -0.209971805478275 0.00685581280914592 NA NA NA hsa-miR-491-5p FLT3LG -1.04307210952796 1.14586501470398e-15 -0.341567133322199 0.00313331665479677 miRanda -0.167637903921863 2.255502889352e-08 NA NA NA hsa-miR-331-3p FLT4 0.74441480542886 1.17071235477799e-07 -1.21716420627977 1.17202457914118e-32 miRNAWalker2_validate -0.256733379585136 1.34101220391357e-24 NA NA NA hsa-miR-429 FLT4 2.84108892259147 3.88520896426515e-64 -1.21716420627977 1.17202457914118e-32 miRanda;miRNATAP -0.220062777103595 1.23886320860694e-29 NA NA NA hsa-miR-128-3p FOXO4 0.90296715955238 9.925204823863e-23 -1.05595514672013 4.31153744833776e-38 MirTarget -0.161198942750576 2.12049093190769e-07 NA NA NA hsa-miR-193a-3p FOXO4 0.310617999804917 0.00477640270974957 -1.05595514672013 4.31153744833776e-38 miRanda;miRNATAP -0.109734949631435 3.8761448681724e-05 NA NA NA hsa-miR-2355-5p FOXO4 -0.221733044425126 0.0231054202524677 -1.05595514672013 4.31153744833776e-38 MirTarget -0.113344024452734 0.000172413043926855 NA NA NA hsa-miR-429 FOXO4 2.84108892259147 3.88520896426515e-64 -1.05595514672013 4.31153744833776e-38 miRNATAP -0.115688900706391 5.27951610832256e-13 NA NA NA hsa-miR-484 FOXO4 0.349444060004737 0.00154491249625173 -1.05595514672013 4.31153744833776e-38 miRNATAP -0.167677304601357 2.13054805249566e-10 NA NA NA hsa-miR-590-5p FOXO4 0.746515607868274 8.51300479640125e-09 -1.05595514672013 4.31153744833776e-38 miRanda -0.128592961249984 8.71019533744029e-09 NA NA NA hsa-miR-96-5p FOXO4 3.24596558166606 1.92296159041707e-98 -1.05595514672013 4.31153744833776e-38 MirTarget;TargetScan;miRNATAP -0.14501869664246 2.56351910068554e-18 NA NA NA hsa-miR-106b-5p GAB1 1.22477789913175 2.31787213143326e-32 -0.692166188366933 9.18798859765721e-16 MirTarget;miRNATAP -0.265529229523575 2.35717782198394e-22 NA NA NA hsa-miR-132-3p GAB1 -0.0365213889238607 0.668598301088667 -0.692166188366933 9.18798859765721e-16 mirMAP -0.118417638517452 0.000834185182165966 NA NA NA hsa-miR-141-3p GAB1 2.99777540204168 1.26370498493024e-78 -0.692166188366933 9.18798859765721e-16 MirTarget;TargetScan -0.120372236176324 8.11764203508008e-13 NA NA NA hsa-miR-142-5p GAB1 1.16509303143593 1.96641162209073e-13 -0.692166188366933 9.18798859765721e-16 MirTarget -0.120536714246304 6.90908728241437e-11 NA NA NA hsa-miR-15b-3p GAB1 1.12898579025388 1.18050912917317e-14 -0.692166188366933 9.18798859765721e-16 mirMAP -0.105071383943572 1.69408861893693e-07 NA NA NA hsa-miR-16-1-3p GAB1 1.30142784811196 2.53343713753744e-29 -0.692166188366933 9.18798859765721e-16 mirMAP -0.213655194571304 2.87330948450093e-16 NA NA NA hsa-miR-17-5p GAB1 0.599531757298529 1.07318660415906e-05 -0.692166188366933 9.18798859765721e-16 MirTarget;TargetScan;miRNATAP -0.166508663554131 1.41670601959795e-14 NA NA NA hsa-miR-181d-5p GAB1 0.782618466877349 1.2821116358212e-09 -0.692166188366933 9.18798859765721e-16 miRNAWalker2_validate -0.197894063657779 2.27998911760387e-18 NA NA NA hsa-miR-18a-5p GAB1 0.969066793715868 1.69069796425892e-08 -0.692166188366933 9.18798859765721e-16 MirTarget;miRNATAP -0.178021538614324 3.83791153370437e-26 NA NA NA hsa-miR-20a-5p GAB1 0.44979911120222 0.000602386964327228 -0.692166188366933 9.18798859765721e-16 MirTarget;miRNATAP -0.217024726665105 2.22970726487022e-22 NA NA NA hsa-miR-221-3p GAB1 -0.317970198201501 0.00910855267413448 -0.692166188366933 9.18798859765721e-16 MirTarget;miRNATAP -0.175863900871287 4.94118354663136e-13 NA NA NA hsa-miR-27a-3p GAB1 0.388496361379095 1.42373532086331e-05 -0.692166188366933 9.18798859765721e-16 MirTarget;miRNATAP -0.230466088398271 3.87160694356094e-12 NA NA NA hsa-miR-29b-3p GAB1 0.438847962603729 6.46722433236121e-05 -0.692166188366933 9.18798859765721e-16 MirTarget -0.124848530912299 4.4837791858854e-06 NA NA NA hsa-miR-30e-5p GAB1 0.293491764699475 0.000372291967271834 -0.692166188366933 9.18798859765721e-16 mirMAP -0.125122850910394 0.000618447074562699 NA NA NA hsa-miR-361-5p GAB1 -0.0996867547900457 0.095428250126326 -0.692166188366933 9.18798859765721e-16 mirMAP;miRNATAP -0.176392979912877 0.000548417816639652 NA NA NA hsa-miR-374a-3p GAB1 0.34122393953022 2.28714105382856e-05 -0.692166188366933 9.18798859765721e-16 mirMAP -0.15656876613192 2.69951501754753e-05 NA NA NA hsa-miR-429 GAB1 2.84108892259147 3.88520896426515e-64 -0.692166188366933 9.18798859765721e-16 miRanda;miRNATAP -0.114062148935215 3.49638206904719e-12 NA NA NA hsa-miR-590-3p GAB1 1.27438512890514 1.03164723481469e-23 -0.692166188366933 9.18798859765721e-16 miRanda;mirMAP -0.167661711181516 1.79077155519265e-12 NA NA NA hsa-miR-93-5p GAB1 1.01788600209314 1.24312921618126e-21 -0.692166188366933 9.18798859765721e-16 MirTarget;miRNATAP -0.267064396496082 2.49206125940333e-23 NA NA NA hsa-miR-148a-5p GAB2 0.572692271754695 2.14306251522796e-06 -0.761937427307663 6.84268214136315e-10 mirMAP -0.158121363461644 6.7748850736616e-06 NA NA NA hsa-miR-181a-5p GAB2 0.635863607630183 6.72486918157744e-11 -0.761937427307663 6.84268214136315e-10 mirMAP -0.149550304535147 0.00059228394946284 NA NA NA hsa-miR-181b-5p GAB2 1.22749257795094 1.21998198830919e-27 -0.761937427307663 6.84268214136315e-10 mirMAP -0.148568032258724 5.17086308939046e-05 NA NA NA hsa-miR-429 GAB2 2.84108892259147 3.88520896426515e-64 -0.761937427307663 6.84268214136315e-10 miRNATAP -0.100535333411 1.97391196154341e-05 NA NA NA hsa-miR-590-3p GAB2 1.27438512890514 1.03164723481469e-23 -0.761937427307663 6.84268214136315e-10 PITA;miRanda -0.117540140861409 0.000598216231310602 NA NA NA hsa-miR-23a-3p GNB2 -0.217176729033818 0.00962615056202409 0.88241249965083 1.56989231821362e-33 miRNAWalker2_validate -0.223826338992611 4.29157165949292e-13 NA NA NA hsa-miR-30b-3p GNB3 -0.536462824497982 2.41814659272548e-05 -0.218781005289026 0.156021511354067 MirTarget -0.10995518264951 0.00843692403427671 NA NA NA hsa-miR-326 GNB3 -1.54449030848141 1.04703417845594e-17 -0.218781005289026 0.156021511354067 miRanda -0.159948449709777 2.11022567862306e-08 NA NA NA hsa-miR-330-5p GNB3 0.626063225953928 3.42215028606779e-09 -0.218781005289026 0.156021511354067 miRanda -0.169128654107362 0.000640956496089397 NA NA NA hsa-miR-491-5p GNB3 -1.04307210952796 1.14586501470398e-15 -0.218781005289026 0.156021511354067 miRanda -0.157999452002575 8.19626078438683e-05 NA NA NA hsa-miR-29c-3p GNB4 -0.0652732378039769 0.563774115756922 -0.0279351136019024 0.79353569056173 miRNAWalker2_validate;MirTarget -0.301018105639441 1.91560837681814e-21 NA NA NA hsa-miR-361-5p GNB4 -0.0996867547900457 0.095428250126326 -0.0279351136019024 0.79353569056173 miRanda;miRNATAP -0.177421789581256 0.00432005891214685 NA NA NA hsa-miR-128-3p GNB5 0.90296715955238 9.925204823863e-23 -0.407104708333545 6.5228202573912e-07 miRNAWalker2_validate -0.114359353671188 0.000132372943896389 NA NA NA hsa-miR-130b-3p GNB5 1.38122163823846 1.00932179737836e-26 -0.407104708333545 6.5228202573912e-07 miRNAWalker2_validate -0.138451761651205 5.12903842421723e-11 NA NA NA hsa-miR-17-5p GNB5 0.599531757298529 1.07318660415906e-05 -0.407104708333545 6.5228202573912e-07 TargetScan -0.174552122552597 6.18835184294834e-18 NA NA NA hsa-miR-425-5p GNB5 0.719898949241718 6.01079610190374e-08 -0.407104708333545 6.5228202573912e-07 miRNAWalker2_validate -0.128350915841136 8.24892867293889e-10 NA NA NA hsa-miR-590-3p GNB5 1.27438512890514 1.03164723481469e-23 -0.407104708333545 6.5228202573912e-07 miRanda -0.130708855700002 5.67204097508921e-09 NA NA NA hsa-miR-320b GNG11 0.412787504747938 0.00113457276903985 -2.08770328232076 1.27194301059522e-79 miRanda -0.183001196145562 2.81304752037874e-08 NA NA NA hsa-miR-330-5p GNG11 0.626063225953928 3.42215028606779e-09 -2.08770328232076 1.27194301059522e-79 miRanda -0.363851891974706 2.48648847018044e-21 NA NA NA hsa-miR-107 GNG12 0.678998026350662 2.56224148930538e-16 -1.00662202078145 1.13075382846906e-21 miRanda -0.551701699322264 2.91176766840327e-39 NA NA NA hsa-miR-30d-3p GNG12 0.264544633563642 0.00755023189129747 -1.00662202078145 1.13075382846906e-21 mirMAP -0.208468484284917 2.20758275785736e-08 NA NA NA hsa-miR-374a-5p GNG12 -0.239709888246804 0.00309819667153627 -1.00662202078145 1.13075382846906e-21 mirMAP -0.224009250033915 9.67825178709072e-07 NA NA NA hsa-miR-374b-5p GNG12 -0.466781429946153 1.17238311619116e-08 -1.00662202078145 1.13075382846906e-21 mirMAP -0.149043145224379 0.000959250373367468 NA NA NA hsa-miR-423-5p GNG12 -0.0644843381453004 0.462275547464843 -1.00662202078145 1.13075382846906e-21 miRNAWalker2_validate -0.232418945817642 3.66766754252117e-08 NA NA NA hsa-miR-429 GNG12 2.84108892259147 3.88520896426515e-64 -1.00662202078145 1.13075382846906e-21 miRanda -0.170551562257512 1.90032220822832e-17 NA NA NA hsa-miR-455-5p GNG12 0.284641224662773 0.0357572339594277 -1.00662202078145 1.13075382846906e-21 miRanda -0.136447911297092 5.25157686814491e-07 NA NA NA hsa-miR-508-3p GNG12 0.260698649973977 0.189926238144551 -1.00662202078145 1.13075382846906e-21 mirMAP -0.121287386585328 6.28721215718235e-11 NA NA NA hsa-miR-542-3p GNG12 0.568822103820889 8.5699075257651e-07 -1.00662202078145 1.13075382846906e-21 miRanda -0.112752886973826 0.000401656809905115 NA NA NA hsa-miR-590-3p GNG12 1.27438512890514 1.03164723481469e-23 -1.00662202078145 1.13075382846906e-21 miRanda;mirMAP -0.230577467147612 2.85613249871964e-15 NA NA NA hsa-miR-590-5p GNG12 0.746515607868274 8.51300479640125e-09 -1.00662202078145 1.13075382846906e-21 PITA -0.177407665286786 2.67698443222439e-10 NA NA NA hsa-miR-96-5p GNG12 3.24596558166606 1.92296159041707e-98 -1.00662202078145 1.13075382846906e-21 TargetScan -0.177675699622518 2.20766570176543e-17 NA NA NA hsa-miR-511-5p GNG13 -2.27545475897362 3.84085514050558e-36 3.60156617640628 6.90742745616058e-33 MirTarget -0.512118109882972 5.35501018269789e-20 NA NA NA hsa-miR-181a-5p GNG2 0.635863607630183 6.72486918157744e-11 -1.9182405505051 4.75840171347434e-62 miRNATAP -0.158622872266113 0.000268518996801588 NA NA NA hsa-miR-181b-5p GNG2 1.22749257795094 1.21998198830919e-27 -1.9182405505051 4.75840171347434e-62 miRNATAP -0.242792923107725 2.59948071095444e-11 NA NA NA hsa-miR-181c-5p GNG2 0.574847839298605 4.51287502066478e-07 -1.9182405505051 4.75840171347434e-62 miRNATAP -0.238454563522782 1.20468334925699e-10 NA NA NA hsa-miR-21-5p GNG2 2.32007501846389 3.08394781855554e-137 -1.9182405505051 4.75840171347434e-62 miRNATAP -0.40885794761468 1.88540041022037e-27 NA NA NA hsa-miR-29b-3p GNG2 0.438847962603729 6.46722433236121e-05 -1.9182405505051 4.75840171347434e-62 miRNATAP -0.177191825291211 4.85752847508701e-06 NA NA NA hsa-miR-30d-3p GNG2 0.264544633563642 0.00755023189129747 -1.9182405505051 4.75840171347434e-62 mirMAP -0.314140730350831 2.09757667757834e-13 NA NA NA hsa-miR-324-5p GNG2 0.211552647440779 0.139408130311654 -1.9182405505051 4.75840171347434e-62 miRanda -0.111829031139688 0.000180436111790897 NA NA NA hsa-miR-330-5p GNG2 0.626063225953928 3.42215028606779e-09 -1.9182405505051 4.75840171347434e-62 miRanda -0.128481680756102 0.00136130772027182 NA NA NA hsa-miR-429 GNG2 2.84108892259147 3.88520896426515e-64 -1.9182405505051 4.75840171347434e-62 miRanda;miRNATAP -0.366896431796571 2.59270002688012e-63 NA NA NA hsa-miR-590-3p GNG2 1.27438512890514 1.03164723481469e-23 -1.9182405505051 4.75840171347434e-62 PITA;miRanda;mirMAP;miRNATAP -0.176213741742696 2.38118796696407e-07 NA NA NA hsa-miR-590-5p GNG2 0.746515607868274 8.51300479640125e-09 -1.9182405505051 4.75840171347434e-62 miRanda;miRNATAP -0.162596484872571 6.15767106446387e-07 NA NA NA hsa-miR-218-5p GNG3 -1.02621788318234 2.9221925445771e-23 1.11699723966564 1.27168600858717e-10 MirTarget -0.29417055790856 2.01234117411904e-07 NA NA NA hsa-let-7a-5p GNG5 -0.210286642041636 0.0072546234707717 0.720669896372741 1.33713375996743e-23 MirTarget;TargetScan;miRNATAP -0.263609332795226 1.89983891846224e-16 NA NA NA hsa-let-7b-5p GNG5 -0.54215483448257 7.21347617597858e-08 0.720669896372741 1.33713375996743e-23 MirTarget;miRNATAP -0.215365938729338 1.98107309244769e-18 NA NA NA hsa-let-7c-5p GNG5 -1.9415540533505 9.55250745007793e-48 0.720669896372741 1.33713375996743e-23 MirTarget -0.130308599771332 1.4272369414858e-13 NA NA NA hsa-miR-100-5p GNG5 -1.89453309391092 5.00588682382388e-51 0.720669896372741 1.33713375996743e-23 miRNAWalker2_validate -0.170666649924024 2.31239110416299e-20 NA NA NA hsa-miR-199a-5p GNG5 -0.314703593105081 0.00909304983051124 0.720669896372741 1.33713375996743e-23 MirTarget;miRanda;miRNATAP -0.103725476670797 7.1766087314945e-07 NA NA NA hsa-miR-141-3p GNG7 2.99777540204168 1.26370498493024e-78 -1.27893544175867 1.22567787829192e-21 MirTarget;TargetScan;miRNATAP -0.160816727393679 1.22991601143051e-09 NA NA NA hsa-miR-182-5p GNG7 2.36408084103818 2.60011457600281e-72 -1.27893544175867 1.22567787829192e-21 mirMAP -0.192436587268947 3.0582156776103e-09 NA NA NA hsa-miR-185-3p GNG7 0.86591374114446 7.8790769678542e-10 -1.27893544175867 1.22567787829192e-21 mirMAP -0.277859437819126 4.04643911165602e-17 NA NA NA hsa-miR-18a-5p GNG7 0.969066793715868 1.69069796425892e-08 -1.27893544175867 1.22567787829192e-21 mirMAP -0.102334215711126 0.000163584996294418 NA NA NA hsa-miR-193b-5p GNG7 -0.481487407783336 0.000206895781789619 -1.27893544175867 1.22567787829192e-21 mirMAP -0.208151006145478 7.31519163743523e-09 NA NA NA hsa-miR-1976 GNG7 0.289190368864725 0.00167092758216584 -1.27893544175867 1.22567787829192e-21 mirMAP -0.300152613953244 3.81622005339607e-09 NA NA NA hsa-miR-22-5p GNG7 0.238328801322329 0.0377496760295305 -1.27893544175867 1.22567787829192e-21 mirMAP -0.260659828457892 1.55588475652111e-10 NA NA NA hsa-miR-23a-3p GNG7 -0.217176729033818 0.00962615056202409 -1.27893544175867 1.22567787829192e-21 mirMAP -0.241969817588217 1.71784058793468e-05 NA NA NA hsa-miR-29b-3p GNG7 0.438847962603729 6.46722433236121e-05 -1.27893544175867 1.22567787829192e-21 mirMAP -0.166028116001799 0.000102220857349818 NA NA NA hsa-miR-3127-5p GNG7 0.903405128081314 1.1325923598273e-12 -1.27893544175867 1.22567787829192e-21 mirMAP -0.264037103319252 2.7885903673376e-13 NA NA NA hsa-miR-330-5p GNG7 0.626063225953928 3.42215028606779e-09 -1.27893544175867 1.22567787829192e-21 mirMAP -0.360143214353564 1.04384209007179e-16 NA NA NA hsa-miR-532-3p GNG7 -0.395473145042459 0.00686714288452761 -1.27893544175867 1.22567787829192e-21 mirMAP -0.134877459760651 2.59162844952196e-05 NA NA NA hsa-miR-590-3p GNG7 1.27438512890514 1.03164723481469e-23 -1.27893544175867 1.22567787829192e-21 PITA;miRanda;mirMAP -0.234865237619927 3.35435901958928e-10 NA NA NA hsa-miR-671-5p GNG7 1.55248047544015 7.7377784125886e-33 -1.27893544175867 1.22567787829192e-21 mirMAP -0.243406330452064 3.86780682385241e-12 NA NA NA hsa-miR-766-3p GNG7 0.496790679032227 8.22686414022553e-05 -1.27893544175867 1.22567787829192e-21 MirTarget -0.263281448404197 8.01439191181685e-13 NA NA NA hsa-miR-96-5p GNG7 3.24596558166606 1.92296159041707e-98 -1.27893544175867 1.22567787829192e-21 mirMAP -0.189536520051665 1.57219350207875e-12 NA NA NA hsa-miR-100-5p GRB2 -1.89453309391092 5.00588682382388e-51 0.639828372471576 5.6864573011903e-23 miRNAWalker2_validate -0.156661486141178 3.5519143452408e-21 NA NA NA hsa-miR-378a-3p GRB2 -1.79882978380301 1.05005373951733e-38 0.639828372471576 5.6864573011903e-23 miRNAWalker2_validate;MirTarget;miRNATAP -0.128042134644829 1.17944311772052e-16 NA NA NA hsa-miR-378c GRB2 -1.79697571999492 1.07363220292403e-41 0.639828372471576 5.6864573011903e-23 MirTarget;miRNATAP -0.126006904107165 4.99041375742704e-15 NA NA NA hsa-let-7a-2-3p GRIN1 -1.30646060964956 1.05363588067753e-14 0.816238120637237 0.00018247309853884 mirMAP -0.299710615909561 5.20724620156882e-12 NA NA NA hsa-miR-16-5p GRIN1 0.46835991343556 1.91125356547776e-06 0.816238120637237 0.00018247309853884 mirMAP -0.561606040615573 7.71879697879405e-14 NA NA NA hsa-miR-185-3p GRIN1 0.86591374114446 7.8790769678542e-10 0.816238120637237 0.00018247309853884 MirTarget;mirMAP;miRNATAP -0.27021871894913 4.0877416090495e-07 NA NA NA hsa-miR-2355-5p GRIN1 -0.221733044425126 0.0231054202524677 0.816238120637237 0.00018247309853884 mirMAP -0.497753874550946 7.25923922997807e-11 NA NA NA hsa-miR-30b-3p GRIN1 -0.536462824497982 2.41814659272548e-05 0.816238120637237 0.00018247309853884 mirMAP -0.268686923238083 5.30110285589648e-06 NA NA NA hsa-miR-326 GRIN1 -1.54449030848141 1.04703417845594e-17 0.816238120637237 0.00018247309853884 mirMAP -0.201552966291767 6.93125755394049e-07 NA NA NA hsa-miR-330-5p GRIN1 0.626063225953928 3.42215028606779e-09 0.816238120637237 0.00018247309853884 mirMAP -0.33301237210295 2.03490154511177e-06 NA NA NA hsa-miR-335-5p GRIN1 -2.61355235628987 2.6462884165886e-51 0.816238120637237 0.00018247309853884 mirMAP -0.120216864037747 0.00310374497053473 NA NA NA hsa-miR-491-5p GRIN1 -1.04307210952796 1.14586501470398e-15 0.816238120637237 0.00018247309853884 mirMAP -0.167760278947317 0.0032842264245084 NA NA NA hsa-miR-628-5p GRIN1 0.107482129280898 0.569748271582925 0.816238120637237 0.00018247309853884 PITA -0.229657152819933 5.4799359639748e-09 NA NA NA hsa-miR-744-5p GRIN1 0.114590984077262 0.312916425462546 0.816238120637237 0.00018247309853884 mirMAP -0.291419385377641 1.02988224182579e-05 NA NA NA hsa-let-7a-3p GRIN2A 0.466622567891891 3.70886257943079e-07 -1.82536115377551 6.42782297852272e-17 mirMAP -0.360255564733551 1.36661379764002e-05 NA NA NA hsa-let-7f-1-3p GRIN2A 0.37532726250321 0.00156021688753682 -1.82536115377551 6.42782297852272e-17 mirMAP -0.20204244443868 0.00194220128817589 NA NA NA hsa-miR-107 GRIN2A 0.678998026350662 2.56224148930538e-16 -1.82536115377551 6.42782297852272e-17 miRanda -0.634643900446771 1.74480549742468e-12 NA NA NA hsa-miR-130b-5p GRIN2A 1.0573161199584 2.55177349228739e-12 -1.82536115377551 6.42782297852272e-17 mirMAP -0.185749598518644 0.0001926764236241 NA NA NA hsa-miR-15b-3p GRIN2A 1.12898579025388 1.18050912917317e-14 -1.82536115377551 6.42782297852272e-17 mirMAP -0.367723505180179 4.13099360140055e-13 NA NA NA hsa-miR-182-5p GRIN2A 2.36408084103818 2.60011457600281e-72 -1.82536115377551 6.42782297852272e-17 mirMAP -0.39854406378696 2.55857710432754e-14 NA NA NA hsa-miR-193a-3p GRIN2A 0.310617999804917 0.00477640270974957 -1.82536115377551 6.42782297852272e-17 miRanda -0.305814317721943 1.00633001437751e-05 NA NA NA hsa-miR-200b-3p GRIN2A 2.11744072703209 1.66710572104191e-43 -1.82536115377551 6.42782297852272e-17 TargetScan -0.266628421722217 1.32487494509074e-08 NA NA NA hsa-miR-25-3p GRIN2A -0.00546790775985073 0.944061771389468 -1.82536115377551 6.42782297852272e-17 mirMAP -0.379262124505149 0.000123020189631634 NA NA NA hsa-miR-320b GRIN2A 0.412787504747938 0.00113457276903985 -1.82536115377551 6.42782297852272e-17 PITA -0.212772282568418 0.000429380529033636 NA NA NA hsa-miR-338-3p GRIN2A 0.0799903526884966 0.575137668326679 -1.82536115377551 6.42782297852272e-17 miRanda -0.202162699890148 0.00015752111775227 NA NA NA hsa-miR-342-3p GRIN2A 1.21944481975657 6.81914373001202e-19 -1.82536115377551 6.42782297852272e-17 miRanda -0.268932330188161 6.87885297351993e-07 NA NA NA hsa-miR-590-3p GRIN2A 1.27438512890514 1.03164723481469e-23 -1.82536115377551 6.42782297852272e-17 miRanda;mirMAP -0.384291914428919 2.35350032020831e-10 NA NA NA hsa-miR-590-5p GRIN2A 0.746515607868274 8.51300479640125e-09 -1.82536115377551 6.42782297852272e-17 miRanda -0.323660777846926 2.55600466572774e-08 NA NA NA hsa-miR-7-1-3p GRIN2A 0.686579567507582 1.20731554448806e-07 -1.82536115377551 6.42782297852272e-17 mirMAP -0.388791010911417 1.86374039153238e-11 NA NA NA hsa-miR-92a-3p GRIN2A -0.342420481092807 0.000732275969501111 -1.82536115377551 6.42782297852272e-17 mirMAP -0.199917826784836 0.00807142549119395 NA NA NA hsa-let-7a-3p HGF 0.466622567891891 3.70886257943079e-07 -1.50227719275535 2.60659514703213e-20 mirMAP -0.37044217111857 1.87158404007688e-09 NA NA NA hsa-miR-141-3p HGF 2.99777540204168 1.26370498493024e-78 -1.50227719275535 2.60659514703213e-20 MirTarget;TargetScan -0.460530345225581 6.82815824837891e-52 NA NA NA hsa-miR-181a-5p HGF 0.635863607630183 6.72486918157744e-11 -1.50227719275535 2.60659514703213e-20 mirMAP -0.229180145731049 7.99295141524896e-05 NA NA NA hsa-miR-181b-5p HGF 1.22749257795094 1.21998198830919e-27 -1.50227719275535 2.60659514703213e-20 mirMAP -0.309758876766791 1.99330459381299e-10 NA NA NA hsa-miR-181c-5p HGF 0.574847839298605 4.51287502066478e-07 -1.50227719275535 2.60659514703213e-20 mirMAP -0.325896473603488 4.31927246381495e-11 NA NA NA hsa-miR-200a-3p HGF 2.55218480823434 2.96135446816238e-51 -1.50227719275535 2.60659514703213e-20 MirTarget -0.395550183948552 6.66851532585504e-39 NA NA NA hsa-miR-203a-3p HGF 1.67084394806148 6.06522273352132e-14 -1.50227719275535 2.60659514703213e-20 MirTarget -0.135558542998366 6.49068618028159e-08 NA NA NA hsa-miR-29a-5p HGF 0.334183773952055 0.00445137265870197 -1.50227719275535 2.60659514703213e-20 mirMAP -0.20905674153194 1.72665124213689e-05 NA NA NA hsa-miR-30b-5p HGF -0.46540603860146 2.4709940429591e-05 -1.50227719275535 2.60659514703213e-20 mirMAP -0.165128975760674 0.00139400110552165 NA NA NA hsa-miR-30c-5p HGF -0.393222674580066 8.06961465717306e-05 -1.50227719275535 2.60659514703213e-20 mirMAP -0.148910356466254 0.00939828977159023 NA NA NA hsa-miR-30d-5p HGF -0.247082219011045 0.00406717930063148 -1.50227719275535 2.60659514703213e-20 mirMAP -0.234640404839747 0.000434087952565876 NA NA NA hsa-miR-30e-5p HGF 0.293491764699475 0.000372291967271834 -1.50227719275535 2.60659514703213e-20 mirMAP -0.36586551099525 1.24219852188022e-07 NA NA NA hsa-miR-338-3p HGF 0.0799903526884966 0.575137668326679 -1.50227719275535 2.60659514703213e-20 miRanda -0.165633335494788 3.4386025988981e-05 NA NA NA hsa-miR-429 HGF 2.84108892259147 3.88520896426515e-64 -1.50227719275535 2.60659514703213e-20 miRanda -0.390119016718709 2.48108439155069e-38 NA NA NA hsa-miR-590-3p HGF 1.27438512890514 1.03164723481469e-23 -1.50227719275535 2.60659514703213e-20 miRanda;mirMAP -0.405090232781221 1.5991156344667e-19 NA NA NA hsa-miR-590-5p HGF 0.746515607868274 8.51300479640125e-09 -1.50227719275535 2.60659514703213e-20 miRanda -0.432886188104826 2.68689870271352e-24 NA NA NA hsa-miR-7-1-3p HGF 0.686579567507582 1.20731554448806e-07 -1.50227719275535 2.60659514703213e-20 mirMAP -0.201885417951517 3.66160567897647e-06 NA NA NA hsa-let-7a-5p HRAS -0.210286642041636 0.0072546234707717 0.871315771945202 9.54693368299171e-15 miRNAWalker2_validate;miRTarBase -0.156144832596741 0.00194814074250424 20607356;23134218;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;;progression glioblastoma;lung squamous cell cancer;lung cancer;lung cancer;pancreatic cancer hsa-let-7b-5p HRAS -0.54215483448257 7.21347617597858e-08 0.871315771945202 9.54693368299171e-15 miRTarBase -0.245640732103343 1.64072414700874e-10 20607356;20881268;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;On the basis of these data we suggest that the downregulation of let-7b and let-7e targeting K-ras and the upregulation of miR-17* a CRC marker could be considered as candidate molecular markers of cetuximab resistance;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;drug resistance;;;progression glioblastoma;colorectal cancer;lung cancer;lung cancer;pancreatic cancer hsa-miR-143-3p HRAS -1.23248181631499 4.74160976678504e-28 0.871315771945202 9.54693368299171e-15 miRNAWalker2_validate;miRTarBase -0.13171025180707 9.59955008801748e-05 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-766-3p HRAS 0.496790679032227 8.22686414022553e-05 0.871315771945202 9.54693368299171e-15 MirTarget -0.107283016649624 0.000532542374235056 NA NA NA hsa-miR-29b-3p HTR7 0.438847962603729 6.46722433236121e-05 -0.492907790788569 0.000495104453533872 miRNATAP -0.279249338489091 1.85397179965756e-10 NA NA NA hsa-miR-324-5p HTR7 0.211552647440779 0.139408130311654 -0.492907790788569 0.000495104453533872 miRanda -0.262325978287957 4.67894640359729e-15 NA NA NA hsa-miR-330-3p HTR7 0.432728362037032 0.00041335506960812 -0.492907790788569 0.000495104453533872 miRNATAP -0.113298130501069 0.00482973400194157 NA NA NA hsa-miR-330-5p HTR7 0.626063225953928 3.42215028606779e-09 -0.492907790788569 0.000495104453533872 miRanda;miRNATAP -0.243926589475729 7.53981419044965e-08 NA NA NA hsa-let-7a-3p IGF1 0.466622567891891 3.70886257943079e-07 -2.74966407318656 1.16668946763881e-41 mirMAP -0.598494517106358 2.99480834420479e-14 NA NA NA hsa-let-7f-1-3p IGF1 0.37532726250321 0.00156021688753682 -2.74966407318656 1.16668946763881e-41 mirMAP -0.284984074850365 5.12019686555637e-06 NA NA NA hsa-miR-130b-3p IGF1 1.38122163823846 1.00932179737836e-26 -2.74966407318656 1.16668946763881e-41 MirTarget -0.632738321082739 2.08097755219068e-32 NA NA NA hsa-miR-142-3p IGF1 1.53951237846104 2.06769936282034e-17 -2.74966407318656 1.16668946763881e-41 miRanda -0.123324920262687 0.00187203848886841 NA NA NA hsa-miR-148a-5p IGF1 0.572692271754695 2.14306251522796e-06 -2.74966407318656 1.16668946763881e-41 mirMAP -0.165502731566367 0.00629257314556201 NA NA NA hsa-miR-155-5p IGF1 1.09766314984151 4.55650930885814e-15 -2.74966407318656 1.16668946763881e-41 mirMAP -0.165951614876576 0.00129161967089585 NA NA NA hsa-miR-15b-3p IGF1 1.12898579025388 1.18050912917317e-14 -2.74966407318656 1.16668946763881e-41 mirMAP -0.538169881674298 1.72833038996145e-29 NA NA NA hsa-miR-16-1-3p IGF1 1.30142784811196 2.53343713753744e-29 -2.74966407318656 1.16668946763881e-41 mirMAP -0.666577091007243 4.14343498994569e-26 NA NA NA hsa-miR-181a-5p IGF1 0.635863607630183 6.72486918157744e-11 -2.74966407318656 1.16668946763881e-41 mirMAP -0.494938478163062 2.34360673909487e-11 NA NA NA hsa-miR-181b-5p IGF1 1.22749257795094 1.21998198830919e-27 -2.74966407318656 1.16668946763881e-41 mirMAP -0.585684202347318 2.25280244287885e-21 NA NA NA hsa-miR-181c-5p IGF1 0.574847839298605 4.51287502066478e-07 -2.74966407318656 1.16668946763881e-41 mirMAP -0.395598534798654 5.11211832683976e-10 NA NA NA hsa-miR-186-5p IGF1 -0.426987301460247 1.04129380549315e-05 -2.74966407318656 1.16668946763881e-41 mirMAP -0.219700941598902 0.00375910687826014 NA NA NA hsa-miR-19a-3p IGF1 0.817507952171848 3.76285090469625e-08 -2.74966407318656 1.16668946763881e-41 MirTarget -0.513925086378424 2.94832706936413e-27 NA NA NA hsa-miR-19b-1-5p IGF1 0.647704962003062 3.07687667945597e-07 -2.74966407318656 1.16668946763881e-41 mirMAP -0.553744322104364 7.97205759882393e-23 NA NA NA hsa-miR-19b-3p IGF1 0.139124391010031 0.255658553872934 -2.74966407318656 1.16668946763881e-41 MirTarget -0.446691776662058 5.00619914718767e-14 NA NA NA hsa-miR-20a-3p IGF1 -0.218902047543766 0.179868363625547 -2.74966407318656 1.16668946763881e-41 mirMAP -0.256736318876148 1.0275917705269e-08 NA NA NA hsa-miR-27a-3p IGF1 0.388496361379095 1.42373532086331e-05 -2.74966407318656 1.16668946763881e-41 miRNAWalker2_validate;miRTarBase -0.544265988607736 2.14223289540701e-11 NA NA NA hsa-miR-29b-3p IGF1 0.438847962603729 6.46722433236121e-05 -2.74966407318656 1.16668946763881e-41 MirTarget -0.414656321477745 3.77745108303762e-10 25592039 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 IGF1 3' untranslated region 3'UTR; IGF1 an activator of PI3K/Akt signaling was confirmed as a novel target of miR-29b colorectal cancer hsa-miR-301a-3p IGF1 1.32170168375632 2.12280368957514e-15 -2.74966407318656 1.16668946763881e-41 MirTarget -0.553869611428521 1.38070780054886e-40 NA NA NA hsa-miR-320b IGF1 0.412787504747938 0.00113457276903985 -2.74966407318656 1.16668946763881e-41 miRNATAP -0.353937956338846 8.47295336022305e-10 NA NA NA hsa-miR-362-5p IGF1 -0.248676340901797 0.0726089851456282 -2.74966407318656 1.16668946763881e-41 mirMAP -0.161368577599581 0.00235431302635106 NA NA NA hsa-miR-3913-5p IGF1 0.71890413546147 2.61153227160465e-13 -2.74966407318656 1.16668946763881e-41 mirMAP -0.344116396893892 3.11162487969542e-06 NA NA NA hsa-miR-454-3p IGF1 1.28177672191095 6.84024979484587e-21 -2.74966407318656 1.16668946763881e-41 MirTarget -0.592555267211157 2.36575948576207e-31 NA NA NA hsa-miR-576-5p IGF1 0.0649387707567879 0.588791966096287 -2.74966407318656 1.16668946763881e-41 PITA;mirMAP;miRNATAP -0.338610461178183 2.7172717713968e-08 NA NA NA hsa-miR-590-3p IGF1 1.27438512890514 1.03164723481469e-23 -2.74966407318656 1.16668946763881e-41 MirTarget;miRanda;mirMAP;miRNATAP -0.58985675364928 6.40681378251621e-25 NA NA NA hsa-miR-629-5p IGF1 0.42411327890895 2.46262300605706e-05 -2.74966407318656 1.16668946763881e-41 mirMAP -0.48961361687082 1.21612287765371e-11 NA NA NA hsa-let-7c-5p IGF1R -1.9415540533505 9.55250745007793e-48 0.118209603036572 0.482168850037006 MirTarget -0.15218155714742 0.000174427683240424 NA NA NA hsa-let-7d-5p IGF1R 0.410958462607207 6.07808182756787e-06 0.118209603036572 0.482168850037006 miRNAWalker2_validate;MirTarget;miRNATAP -0.250052725996837 7.84216944881654e-05 25287248 Focusing on the let-7d-5p/3p pair the respectively targeted IGF1R and KRAS were shown to be in a reverse relationship with expression of the respective miRNA which was confirmed in transient transfection assays using let-7d mimic or inhibitor; Targeting of KRAS by let-7d was previous reported; targeting of IGF1R by let-7d-5p was confirmed in luciferase assays in this study colon cancer hsa-let-7i-5p IGF1R -0.333419326258177 3.56960810786801e-08 0.118209603036572 0.482168850037006 MirTarget;miRNATAP -0.668659308812613 1.79577155658529e-12 NA NA NA hsa-miR-140-3p IGF1R -1.25844395244141 5.29222651039892e-33 0.118209603036572 0.482168850037006 mirMAP -0.257373015650615 9.61550249349614e-07 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-140-5p IGF1R -0.755971041589807 9.68060922934542e-14 0.118209603036572 0.482168850037006 PITA;miRNATAP -0.148653480588664 0.0080741246036404 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-146b-5p IGF1R 0.631041661167954 6.20366593452965e-08 0.118209603036572 0.482168850037006 miRanda -0.476741215566141 2.27302563692138e-23 NA NA NA hsa-miR-148a-5p IGF1R 0.572692271754695 2.14306251522796e-06 0.118209603036572 0.482168850037006 mirMAP -0.391801977453846 4.46869543973991e-17 NA NA NA hsa-miR-150-5p IGF1R -0.832049526091211 3.45299201139224e-05 0.118209603036572 0.482168850037006 mirMAP -0.142283823812173 5.38370164694848e-07 NA NA NA hsa-miR-155-5p IGF1R 1.09766314984151 4.55650930885814e-15 0.118209603036572 0.482168850037006 mirMAP -0.389821123327602 4.78445816137562e-23 NA NA NA hsa-miR-15a-5p IGF1R 0.812445324157528 4.50263417099822e-20 0.118209603036572 0.482168850037006 miRNATAP -0.336209414565688 1.21874645332961e-07 NA NA NA hsa-miR-15b-3p IGF1R 1.12898579025388 1.18050912917317e-14 0.118209603036572 0.482168850037006 mirMAP -0.198448695749043 2.64062076757912e-07 NA NA NA hsa-miR-15b-5p IGF1R 0.788659356634696 1.13678211092534e-11 0.118209603036572 0.482168850037006 miRNATAP -0.206027032960709 2.56310348083525e-05 NA NA NA hsa-miR-16-1-3p IGF1R 1.30142784811196 2.53343713753744e-29 0.118209603036572 0.482168850037006 mirMAP -0.14097038784495 0.00570795285012571 NA NA NA hsa-miR-181a-2-3p IGF1R -0.0718643470098321 0.422077954889554 0.118209603036572 0.482168850037006 MirTarget -0.360130400204588 2.19622508166106e-08 NA NA NA hsa-miR-181b-5p IGF1R 1.22749257795094 1.21998198830919e-27 0.118209603036572 0.482168850037006 miRNAWalker2_validate -0.314350444937727 1.52635622217289e-10 NA NA NA hsa-miR-185-5p IGF1R 0.482334746589337 3.68475879959415e-09 0.118209603036572 0.482168850037006 MirTarget -0.547639501693991 2.52288181739065e-15 NA NA NA hsa-miR-186-5p IGF1R -0.426987301460247 1.04129380549315e-05 0.118209603036572 0.482168850037006 mirMAP -0.3758467428144 1.76981090502528e-10 NA NA NA hsa-miR-197-3p IGF1R -0.526589453596294 3.61594599437195e-06 0.118209603036572 0.482168850037006 mirMAP -0.346888473706894 3.79661059911104e-12 NA NA NA hsa-miR-19a-3p IGF1R 0.817507952171848 3.76285090469625e-08 0.118209603036572 0.482168850037006 mirMAP -0.280968212416369 1.34023709702226e-13 NA NA NA hsa-miR-22-5p IGF1R 0.238328801322329 0.0377496760295305 0.118209603036572 0.482168850037006 miRNATAP -0.295682146919029 3.20081591538083e-09 NA NA NA hsa-miR-223-3p IGF1R -0.966406159689943 7.90612601654887e-12 0.118209603036572 0.482168850037006 miRNAWalker2_validate;miRTarBase;MirTarget -0.327294415285608 1.36068714681003e-16 NA NA NA hsa-miR-224-5p IGF1R -2.22249420723892 1.07787949391113e-18 0.118209603036572 0.482168850037006 mirMAP -0.262380884793216 2.0900858366331e-34 NA NA NA hsa-miR-27a-3p IGF1R 0.388496361379095 1.42373532086331e-05 0.118209603036572 0.482168850037006 mirMAP -0.421381250131072 3.92848078456193e-11 NA NA NA hsa-miR-27b-3p IGF1R -0.0796803270437447 0.410503155574393 0.118209603036572 0.482168850037006 mirMAP -0.178939647350548 0.00277834896804242 NA NA NA hsa-miR-28-3p IGF1R -0.815347900986328 3.29387468083828e-30 0.118209603036572 0.482168850037006 miRNATAP -0.227953787002667 0.0037140065116185 NA NA NA hsa-miR-29a-3p IGF1R -0.699539666833076 1.13935003139957e-13 0.118209603036572 0.482168850037006 mirMAP -0.170708697516285 0.00479364896792699 NA NA NA hsa-miR-30e-5p IGF1R 0.293491764699475 0.000372291967271834 0.118209603036572 0.482168850037006 mirMAP -0.273677390130313 9.34606129272947e-05 NA NA NA hsa-miR-320b IGF1R 0.412787504747938 0.00113457276903985 0.118209603036572 0.482168850037006 PITA;mirMAP;miRNATAP -0.128021905768405 0.00503727353000704 NA NA NA hsa-miR-3613-5p IGF1R 1.11067990676844 4.33424951743633e-21 0.118209603036572 0.482168850037006 mirMAP;miRNATAP -0.187739659554805 8.4057598129776e-05 NA NA NA hsa-miR-369-3p IGF1R 0.0880848299432269 0.48519534195924 0.118209603036572 0.482168850037006 PITA -0.197324616652377 1.69203394230354e-05 NA NA NA hsa-miR-374a-5p IGF1R -0.239709888246804 0.00309819667153627 0.118209603036572 0.482168850037006 mirMAP -0.462875503518205 6.29233435988137e-11 NA NA NA hsa-miR-374b-5p IGF1R -0.466781429946153 1.17238311619116e-08 0.118209603036572 0.482168850037006 mirMAP -0.38240327187586 4.43580587406014e-08 NA NA NA hsa-miR-378a-3p IGF1R -1.79882978380301 1.05005373951733e-38 0.118209603036572 0.482168850037006 miRTarBase;MirTarget;miRNATAP -0.410965170800831 1.52092274416319e-26 24119742;25427715;24412052 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS; MiR-378a-3p over-expression in an RMS-derived cell line suppressed IGF1R expression and affected phosphorylated-Akt protein levels;Furthermore miR-378a-3p over-expression or down-regulation could inhibit or enhance insulin-like growth factor 1 receptor IGF1R expression in CRC cells; There was a significantly negative correlation between IGF1R protein expression and miR-378a-3p expression in CRC tissues ;; liver cancer;sarcoma;colorectal cancer hsa-miR-378a-5p IGF1R -2.43173551693523 1.44932837789175e-68 0.118209603036572 0.482168850037006 mirMAP -0.366238005092466 5.06012393985433e-23 24119742;25427715 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS ; liver cancer;sarcoma hsa-miR-378c IGF1R -1.79697571999492 1.07363220292403e-41 0.118209603036572 0.482168850037006 MirTarget;miRNATAP -0.372524048647036 2.92916006594659e-20 NA NA NA hsa-miR-452-5p IGF1R -2.48486455572568 1.24430987974325e-33 0.118209603036572 0.482168850037006 mirMAP -0.344176900884078 2.14757949011712e-41 NA NA NA hsa-miR-455-5p IGF1R 0.284641224662773 0.0357572339594277 0.118209603036572 0.482168850037006 miRNATAP -0.37596874913464 1.77232473048871e-19 NA NA NA hsa-miR-484 IGF1R 0.349444060004737 0.00154491249625173 0.118209603036572 0.482168850037006 miRNAWalker2_validate -0.138614288605464 0.00800305817129001 NA NA NA hsa-miR-495-3p IGF1R -1.67685437612894 1.70634429769052e-34 0.118209603036572 0.482168850037006 mirMAP -0.128987170041706 0.00143461494133436 NA NA NA hsa-miR-500a-3p IGF1R 0.139523673241448 0.185528510741158 0.118209603036572 0.482168850037006 mirMAP -0.595319934777455 3.03106324107414e-29 NA NA NA hsa-miR-532-5p IGF1R 0.0386976222860582 0.682018574136515 0.118209603036572 0.482168850037006 miRNATAP -0.573015490854942 1.08093916899163e-21 NA NA NA hsa-miR-582-3p IGF1R 0.126152488945932 0.333088461939587 0.118209603036572 0.482168850037006 PITA -0.114761029626503 0.00960538341063417 NA NA NA hsa-miR-671-5p IGF1R 1.55248047544015 7.7377784125886e-33 0.118209603036572 0.482168850037006 mirMAP -0.205843673722281 1.93098107239342e-06 NA NA NA hsa-miR-92a-3p IGF1R -0.342420481092807 0.000732275969501111 0.118209603036572 0.482168850037006 miRNAWalker2_validate -0.292401751465085 2.39617627316904e-07 NA NA NA hsa-miR-98-5p IGF1R 0.656336869298973 9.03113188590466e-15 0.118209603036572 0.482168850037006 MirTarget -0.35419321737761 1.24116459021004e-07 NA NA NA hsa-miR-130b-3p IGF2 1.38122163823846 1.00932179737836e-26 -1.80707502143834 9.64580354953106e-21 mirMAP -0.502522463738945 8.75042014015627e-24 NA NA NA hsa-miR-141-3p IGF2 2.99777540204168 1.26370498493024e-78 -1.80707502143834 9.64580354953106e-21 MirTarget;TargetScan -0.526450181465424 1.71357013794482e-47 NA NA NA hsa-miR-148a-3p IGF2 0.706969798912638 5.52538085480485e-09 -1.80707502143834 9.64580354953106e-21 mirMAP -0.483254422697307 7.93109854927416e-19 NA NA NA hsa-miR-148b-3p IGF2 1.0552576751879 1.6679285705231e-29 -1.80707502143834 9.64580354953106e-21 mirMAP -0.894988716311036 1.1779030441463e-40 NA NA NA hsa-miR-192-5p IGF2 1.33366224451777 9.5116159697107e-29 -1.80707502143834 9.64580354953106e-21 mirMAP -0.57061300154468 7.28513686071406e-27 NA NA NA hsa-miR-193a-3p IGF2 0.310617999804917 0.00477640270974957 -1.80707502143834 9.64580354953106e-21 mirMAP -0.376228277380693 8.52000035402321e-10 NA NA NA hsa-miR-19a-3p IGF2 0.817507952171848 3.76285090469625e-08 -1.80707502143834 9.64580354953106e-21 mirMAP -0.500967626901559 2.82727392231526e-30 NA NA NA hsa-miR-19b-3p IGF2 0.139124391010031 0.255658553872934 -1.80707502143834 9.64580354953106e-21 mirMAP -0.523445616011191 5.62894202989734e-22 NA NA NA hsa-miR-200a-3p IGF2 2.55218480823434 2.96135446816238e-51 -1.80707502143834 9.64580354953106e-21 MirTarget -0.43049563526396 2.80291025727271e-32 NA NA NA hsa-miR-210-3p IGF2 2.38367203491819 3.73261999106754e-22 -1.80707502143834 9.64580354953106e-21 MirTarget -0.334005796953098 7.04725823217349e-39 NA NA NA hsa-miR-301a-3p IGF2 1.32170168375632 2.12280368957514e-15 -1.80707502143834 9.64580354953106e-21 mirMAP -0.43546719532613 6.60141842803586e-29 NA NA NA hsa-miR-324-3p IGF2 0.404877731996915 0.000340036423920834 -1.80707502143834 9.64580354953106e-21 MirTarget;miRNATAP -0.609379587853179 1.74562567432832e-25 NA NA NA hsa-miR-339-5p IGF2 -0.211548290465418 0.0685885445822389 -1.80707502143834 9.64580354953106e-21 mirMAP -0.293532322036892 4.938517053805e-07 NA NA NA hsa-miR-342-5p IGF2 1.49554286219821 1.56221300255782e-22 -1.80707502143834 9.64580354953106e-21 MirTarget;mirMAP;miRNATAP -0.241664732659148 1.81332355609559e-08 NA NA NA hsa-miR-34a-5p IGF2 0.129201805242403 0.133261654068224 -1.80707502143834 9.64580354953106e-21 mirMAP -0.242484753846277 0.00229621728593982 NA NA NA hsa-miR-361-3p IGF2 -0.0370446538644886 0.624902392829872 -1.80707502143834 9.64580354953106e-21 mirMAP -0.472218454531822 1.62134013482131e-07 NA NA NA hsa-miR-454-3p IGF2 1.28177672191095 6.84024979484587e-21 -1.80707502143834 9.64580354953106e-21 mirMAP -0.493933025372171 2.31960198985041e-25 NA NA NA hsa-miR-455-5p IGF2 0.284641224662773 0.0357572339594277 -1.80707502143834 9.64580354953106e-21 mirMAP -0.183111096567841 0.000260407841126318 NA NA NA hsa-miR-484 IGF2 0.349444060004737 0.00154491249625173 -1.80707502143834 9.64580354953106e-21 miRNATAP -0.525568576532267 3.49127911615264e-18 NA NA NA hsa-miR-628-5p IGF2 0.107482129280898 0.569748271582925 -1.80707502143834 9.64580354953106e-21 mirMAP -0.173521078128283 1.24958032458701e-06 NA NA NA hsa-miR-744-3p IGF2 -0.00965764791535539 0.955204760097016 -1.80707502143834 9.64580354953106e-21 mirMAP -0.316277215330137 4.25874716426272e-16 NA NA NA hsa-miR-744-5p IGF2 0.114590984077262 0.312916425462546 -1.80707502143834 9.64580354953106e-21 MirTarget -0.461331772327901 6.20346139911665e-15 NA NA NA hsa-miR-9-5p IGF2 0.734772328078424 0.00261982843636383 -1.80707502143834 9.64580354953106e-21 mirMAP -0.218646593239723 1.15371975303189e-15 NA NA NA hsa-miR-93-5p IGF2 1.01788600209314 1.24312921618126e-21 -1.80707502143834 9.64580354953106e-21 miRNAWalker2_validate -0.643440034437039 2.08793079509927e-26 NA NA NA hsa-miR-146b-5p IKBKB 0.631041661167954 6.20366593452965e-08 0.273066826249678 0.00234033685126725 miRanda -0.152908526927625 4.45729055656516e-09 NA NA NA hsa-miR-151a-3p IKBKB 0.3530403796941 3.45015092968892e-05 0.273066826249678 0.00234033685126725 miRNAWalker2_validate -0.109349947297392 0.0025250144404732 NA NA NA hsa-miR-28-5p IKBKB -0.14267073663385 0.0497619246260571 0.273066826249678 0.00234033685126725 miRanda -0.249159305195741 4.36298401628208e-09 NA NA NA hsa-miR-324-5p IKBKB 0.211552647440779 0.139408130311654 0.273066826249678 0.00234033685126725 miRanda -0.118429787871439 3.07201825932054e-08 NA NA NA hsa-miR-330-5p IKBKB 0.626063225953928 3.42215028606779e-09 0.273066826249678 0.00234033685126725 miRanda -0.115452535316074 6.19261343388698e-05 NA NA NA hsa-miR-590-3p IKBKB 1.27438512890514 1.03164723481469e-23 0.273066826249678 0.00234033685126725 miRanda;mirMAP -0.100127823485223 4.7662908944255e-05 NA NA NA hsa-miR-125a-5p IKBKG -0.635694700253268 3.6703235721638e-11 0.490716396303581 1.1441359682473e-11 miRanda -0.228007302003838 2.38576015741085e-19 NA NA NA hsa-miR-140-5p IKBKG -0.755971041589807 9.68060922934542e-14 0.490716396303581 1.1441359682473e-11 miRanda -0.125852887257061 2.14634764656029e-07 NA NA NA hsa-miR-3607-3p IKBKG 0.00697875745616461 0.972073275173643 0.490716396303581 1.1441359682473e-11 mirMAP -0.123479124494569 5.75170407705992e-24 NA NA NA hsa-let-7i-5p INSR -0.333419326258177 3.56960810786801e-08 -0.27492376201698 0.000536820623484817 miRNATAP -0.193128410769688 2.01434335345171e-05 NA NA NA hsa-miR-140-3p INSR -1.25844395244141 5.29222651039892e-33 -0.27492376201698 0.000536820623484817 mirMAP -0.110695842846824 8.67829836185724e-06 NA NA NA hsa-miR-15a-5p INSR 0.812445324157528 4.50263417099822e-20 -0.27492376201698 0.000536820623484817 miRNATAP -0.150758131062672 5.46108942040012e-07 NA NA NA hsa-miR-181a-5p INSR 0.635863607630183 6.72486918157744e-11 -0.27492376201698 0.000536820623484817 mirMAP -0.117022056564807 2.4043081879531e-05 NA NA NA hsa-miR-181b-5p INSR 1.22749257795094 1.21998198830919e-27 -0.27492376201698 0.000536820623484817 mirMAP -0.117276360210961 5.03874837628364e-07 NA NA NA hsa-miR-21-5p INSR 2.32007501846389 3.08394781855554e-137 -0.27492376201698 0.000536820623484817 mirMAP -0.169950201921848 3.994162980573e-12 24804226;27220494;21618027 Downregulation of miR-21 in radioresistant NSCLC A549 cells inhibited the colony-forming ability and proliferation of A549 cells after IR; Moreover silencing miR-21 enhanced apoptosis of A549 cells induced by IR accompanied by decreased phosphorylated-Akt protein level; However PI3K activator IGF-1 reversed suppression of phosphorylated-Akt protein level and promotion of apoptosis of A549 cells after IR caused by miR-21 knockdown; Silencing miR-21 in radioresistant NSCLC A549 cells sensitized them to IR by inhibiting cell proliferation and enhancing cell apoptosis through inhibition of PI3K/Akt signaling pathway;In addition we also demonstrated that miR-21 confers decreased autophagy in cervical cancer cells after IR via the Akt-mTOR signaling pathway;In this study we found that miR-21 expression was upregulated in response to ionizing radiation IR in U251 cells which suggested that miR-21 could be involved in the response of U251 cells to radiation; We showed that a miR-21 inhibitor enhanced IR-induced glioblastoma cell growth arrest and increased the level of apoptosis which was probably caused by abrogation of the G2-M arrest induced by IR ;;drug resistance lung squamous cell cancer;cervical and endocervical cancer;glioblastoma hsa-miR-361-5p INSR -0.0996867547900457 0.095428250126326 -0.27492376201698 0.000536820623484817 miRanda -0.254039592402768 3.53889340380226e-08 NA NA NA hsa-miR-374a-3p INSR 0.34122393953022 2.28714105382856e-05 -0.27492376201698 0.000536820623484817 mirMAP -0.134498034427715 7.19695391572516e-05 NA NA NA hsa-miR-330-5p JMJD7-PLA2G4B 0.626063225953928 3.42215028606779e-09 -0.263856973511927 0.00391874846287315 miRNATAP -0.231724089285207 1.24674326027351e-15 NA NA NA hsa-miR-15a-5p KDR 0.812445324157528 4.50263417099822e-20 -1.26178488366313 1.81783097872036e-35 miRNATAP -0.352492195366687 4.38886869055548e-19 NA NA NA hsa-miR-15b-5p KDR 0.788659356634696 1.13678211092534e-11 -1.26178488366313 1.81783097872036e-35 miRNATAP -0.158920943213795 2.46798947112166e-07 NA NA NA hsa-miR-19b-1-5p KDR 0.647704962003062 3.07687667945597e-07 -1.26178488366313 1.81783097872036e-35 miRNAWalker2_validate -0.228393316601211 4.50410521305737e-16 NA NA NA hsa-miR-200b-3p KDR 2.11744072703209 1.66710572104191e-43 -1.26178488366313 1.81783097872036e-35 miRNAWalker2_validate;miRTarBase;TargetScan -0.262999260406618 3.87053169124588e-34 NA NA NA hsa-miR-200c-3p KDR 2.07038651806183 6.84613386286599e-51 -1.26178488366313 1.81783097872036e-35 miRNATAP -0.289279648433676 3.71227459751374e-34 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-3065-3p KDR 1.62787885002468 6.81477830005026e-19 -1.26178488366313 1.81783097872036e-35 miRNATAP -0.151833949842702 1.66297752718813e-15 NA NA NA hsa-miR-429 KDR 2.84108892259147 3.88520896426515e-64 -1.26178488366313 1.81783097872036e-35 PITA;miRanda;miRNATAP -0.244793933063007 3.13570384816226e-37 NA NA NA hsa-miR-455-5p KDR 0.284641224662773 0.0357572339594277 -1.26178488366313 1.81783097872036e-35 PITA;miRanda;miRNATAP -0.184306159980816 3.7489040476857e-12 NA NA NA hsa-miR-590-3p KDR 1.27438512890514 1.03164723481469e-23 -1.26178488366313 1.81783097872036e-35 miRanda -0.164817675844501 1.21955605160493e-08 NA NA NA hsa-miR-590-5p KDR 0.746515607868274 8.51300479640125e-09 -1.26178488366313 1.81783097872036e-35 miRanda -0.121363305137282 1.22819221367569e-05 NA NA NA hsa-let-7a-3p KIT 0.466622567891891 3.70886257943079e-07 -3.55980779277124 2.17700605158782e-58 mirMAP -0.305708258630377 0.000563948340312811 NA NA NA hsa-miR-128-3p KIT 0.90296715955238 9.925204823863e-23 -3.55980779277124 2.17700605158782e-58 MirTarget -0.716184412196196 4.01386964924962e-17 NA NA NA hsa-miR-130b-3p KIT 1.38122163823846 1.00932179737836e-26 -3.55980779277124 2.17700605158782e-58 miRNATAP -0.463647857585747 2.22404067928257e-14 NA NA NA hsa-miR-193a-3p KIT 0.310617999804917 0.00477640270974957 -3.55980779277124 2.17700605158782e-58 MirTarget;PITA;miRanda;miRNATAP -0.423244385923827 9.1952492703228e-09 NA NA NA hsa-miR-193b-3p KIT -0.0550374855074773 0.65382485898551 -3.55980779277124 2.17700605158782e-58 MirTarget;miRNATAP -0.456397182897406 4.23711519022461e-12 NA NA NA hsa-miR-301a-3p KIT 1.32170168375632 2.12280368957514e-15 -3.55980779277124 2.17700605158782e-58 miRNATAP -0.378579845243396 1.98724994161281e-15 NA NA NA hsa-miR-338-3p KIT 0.0799903526884966 0.575137668326679 -3.55980779277124 2.17700605158782e-58 miRanda -0.311406099865202 4.36514658431642e-08 NA NA NA hsa-miR-342-3p KIT 1.21944481975657 6.81914373001202e-19 -3.55980779277124 2.17700605158782e-58 miRanda -0.435927652877587 2.76373234511638e-14 NA NA NA hsa-miR-34a-5p KIT 0.129201805242403 0.133261654068224 -3.55980779277124 2.17700605158782e-58 MirTarget -0.444920568628705 2.86104030251141e-06 NA NA NA hsa-miR-429 KIT 2.84108892259147 3.88520896426515e-64 -3.55980779277124 2.17700605158782e-58 miRNATAP -0.336829033851034 3.36923704405637e-14 NA NA NA hsa-miR-454-3p KIT 1.28177672191095 6.84024979484587e-21 -3.55980779277124 2.17700605158782e-58 miRNATAP -0.531899770931243 1.67917065615985e-20 NA NA NA hsa-miR-590-3p KIT 1.27438512890514 1.03164723481469e-23 -3.55980779277124 2.17700605158782e-58 miRanda;mirMAP -0.400477071862 6.4525241042505e-10 NA NA NA hsa-miR-671-5p KIT 1.55248047544015 7.7377784125886e-33 -3.55980779277124 2.17700605158782e-58 MirTarget -0.668037376396378 2.34590667378775e-29 NA NA NA hsa-miR-142-5p KITLG 1.16509303143593 1.96641162209073e-13 -0.144677358802896 0.348643719752218 MirTarget;PITA -0.135701636636652 3.48772477572693e-05 NA NA NA hsa-miR-17-3p KITLG 0.721439431208839 7.95900548819742e-10 -0.144677358802896 0.348643719752218 MirTarget -0.552597905855487 2.30753379596766e-38 NA NA NA hsa-miR-181a-5p KITLG 0.635863607630183 6.72486918157744e-11 -0.144677358802896 0.348643719752218 MirTarget -0.145945916834505 0.00678539392102327 NA NA NA hsa-miR-181b-5p KITLG 1.22749257795094 1.21998198830919e-27 -0.144677358802896 0.348643719752218 MirTarget -0.152369506837405 0.000802960531821635 NA NA NA hsa-miR-181c-5p KITLG 0.574847839298605 4.51287502066478e-07 -0.144677358802896 0.348643719752218 MirTarget -0.279559899195876 1.07150063863304e-09 NA NA NA hsa-miR-181d-5p KITLG 0.782618466877349 1.2821116358212e-09 -0.144677358802896 0.348643719752218 MirTarget -0.239492059331143 2.9152716697973e-09 NA NA NA hsa-miR-185-5p KITLG 0.482334746589337 3.68475879959415e-09 -0.144677358802896 0.348643719752218 miRNAWalker2_validate -0.42377124964546 3.25274076407301e-11 NA NA NA hsa-miR-186-5p KITLG -0.426987301460247 1.04129380549315e-05 -0.144677358802896 0.348643719752218 mirMAP -0.428668898343776 1.44268570297994e-15 NA NA NA hsa-miR-19a-3p KITLG 0.817507952171848 3.76285090469625e-08 -0.144677358802896 0.348643719752218 mirMAP -0.366984530985126 8.2317505317704e-27 NA NA NA hsa-miR-19b-3p KITLG 0.139124391010031 0.255658553872934 -0.144677358802896 0.348643719752218 mirMAP -0.416970084520976 4.95393846829457e-23 NA NA NA hsa-miR-22-5p KITLG 0.238328801322329 0.0377496760295305 -0.144677358802896 0.348643719752218 MirTarget -0.181446661957323 8.28817908890659e-05 NA NA NA hsa-miR-222-3p KITLG -0.429279381480379 0.00103945569781115 -0.144677358802896 0.348643719752218 miRNAWalker2_validate -0.246785551483141 6.9109803255638e-10 NA NA NA hsa-miR-23a-3p KITLG -0.217176729033818 0.00962615056202409 -0.144677358802896 0.348643719752218 mirMAP -0.246686544703499 9.72747872547485e-05 NA NA NA hsa-miR-30c-5p KITLG -0.393222674580066 8.06961465717306e-05 -0.144677358802896 0.348643719752218 mirMAP -0.154707158437856 0.00353873917775031 NA NA NA hsa-miR-30e-5p KITLG 0.293491764699475 0.000372291967271834 -0.144677358802896 0.348643719752218 mirMAP -0.479980922617283 4.095991313302e-14 NA NA NA hsa-miR-320b KITLG 0.412787504747938 0.00113457276903985 -0.144677358802896 0.348643719752218 MirTarget;PITA;miRanda -0.251791916761997 1.35049162381435e-09 NA NA NA hsa-miR-345-5p KITLG 0.639728356429512 0.00013070715719672 -0.144677358802896 0.348643719752218 MirTarget -0.110868562663438 0.000425939265168191 NA NA NA hsa-miR-34a-5p KITLG 0.129201805242403 0.133261654068224 -0.144677358802896 0.348643719752218 MirTarget -0.193013612056888 0.00180458841369172 NA NA NA hsa-miR-374a-5p KITLG -0.239709888246804 0.00309819667153627 -0.144677358802896 0.348643719752218 mirMAP -0.198926480140352 0.00244094214640679 NA NA NA hsa-miR-374b-5p KITLG -0.466781429946153 1.17238311619116e-08 -0.144677358802896 0.348643719752218 mirMAP -0.239181492580703 0.000205968556730923 NA NA NA hsa-miR-589-3p KITLG 0.0263457630961427 0.866577983997705 -0.144677358802896 0.348643719752218 mirMAP -0.134074718980368 0.000100452076952808 NA NA NA hsa-miR-590-3p KITLG 1.27438512890514 1.03164723481469e-23 -0.144677358802896 0.348643719752218 MirTarget;PITA;miRanda -0.285492852241295 9.72509971848425e-12 NA NA NA hsa-miR-9-5p KITLG 0.734772328078424 0.00261982843636383 -0.144677358802896 0.348643719752218 MirTarget -0.220147209748711 7.89179813840006e-26 NA NA NA hsa-miR-140-3p KRAS -1.25844395244141 5.29222651039892e-33 0.46818988509622 3.00748217900386e-10 MirTarget -0.245149449217664 6.89860831179258e-27 NA NA NA hsa-miR-143-3p KRAS -1.23248181631499 4.74160976678504e-28 0.46818988509622 3.00748217900386e-10 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.124135749972866 1.80319700574441e-08 22804917;27725862;19137007;26581910;23173124;26824186;21197560 In KRAS mutated tumours increased miR-200b and decreased miR-143 expression were associated with a good PFS;The expression of miR-143 is often down-regulated and it might play an important role by targeting KRAS in colorectal cancer CRC; Dual-luciferase reporter assays were performed to validate whether KRAS was regulated by miR-143; Dual-luciferase assays indicated that KRAS was a direct target of miR-143 as subsequently demonstrated by qPCR and western blot analysis showing that infection of SW480 cells with Ad-ZD55-miR-143 resulted in the down-regulation of KRAS at both mRNA and protein levels;Role of miR 143 targeting KRAS in colorectal tumorigenesis; In particular among a panel of presumed targets generated by in silico analysis that may interact with these aberrantly expressed miRNAs KRAS oncogene has been further experimentally validated as the target of miR-143; First an inverse correlation between KRAS protein and miR-143 in vivo was found; Second KRAS expression in Lovo cells was significantly abolished by treatment with miR-143 mimic whereas miR-143 inhibitor increased KRAS protein level; Third luciferase reporter assay confirmed that miR-143 directly recognize the 3'-untranslated region of KRAS transcripts; Finally inhibition of KRAS expression by miR-143 inhibits constitutive phosphorylation of ERK1/2; Taken together the present study provides the first evidences that miR-143 is significant in suppressing colorectal cancer cell growth through inhibition of KRAS translation;MicroRNA 143 replenishment re sensitizes colorectal cancer cells harboring mutant but not wild type KRAS to paclitaxel treatment; Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS; Combination of miR-143 mimic and paclitaxel induced the onset of apoptosis and reverted in vitro metastatic properties migration and invasion in KRAS mutant tumor cells; MiR-143 thus can be used as a chemosensitizer for the treatment of KRAS mutant tumors and warrants further investigations in in vitro and pre-clinical in vivo models;In turn the level of miR-143 in CRC cells decreasing the amount of MACC1 metastasis-associated in colon cancer-1 and oncogenic KRAS protein may be utilized as a prognostic marker;Stable miR-143 or miR-145 overexpression increased cell sensitivity to cetuximab resulting in a significant increase of cetuximab-mediated ADCC independently of KRAS status;miR 143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS; The expression level of miR-143 and its target gene KRAS were measured by realtime PCR and western blotting respectively; Our results revealed an inverse correlation of expression between miR-143 and KRAS protein in prostate cancer samples Pearson's correlation scatter plots: R = -0.707 P < 0.05; These findings suggest that miR-143 plays an important role in prostate cancer proliferation migration and chemosensitivity by suppressing KRAS and subsequent inactivation of MAPK pathway which provides a potential development of a new approach for the treatment of prostate cancer ;;tumorigenesis;;metastasis;; colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colon cancer;prostate cancer hsa-miR-195-3p KRAS -1.49582726452416 6.53261924105147e-40 0.46818988509622 3.00748217900386e-10 mirMAP -0.144084535908296 1.9114583860958e-11 NA NA NA hsa-miR-30d-5p KRAS -0.247082219011045 0.00406717930063148 0.46818988509622 3.00748217900386e-10 mirMAP;miRNATAP -0.13177346252977 1.09256098608436e-05 NA NA NA hsa-miR-542-3p KRAS 0.568822103820889 8.5699075257651e-07 0.46818988509622 3.00748217900386e-10 miRanda -0.123003016716369 2.33095765684339e-08 NA NA NA hsa-miR-125a-5p KSR1 -0.635694700253268 3.6703235721638e-11 -0.85900089733364 7.21800600691212e-18 miRanda;mirMAP -0.10391798010621 0.00395152356172058 NA NA NA hsa-miR-200a-3p KSR1 2.55218480823434 2.96135446816238e-51 -0.85900089733364 7.21800600691212e-18 mirMAP -0.165442564406279 3.52469026490611e-18 NA NA NA hsa-miR-200b-3p KSR1 2.11744072703209 1.66710572104191e-43 -0.85900089733364 7.21800600691212e-18 TargetScan;mirMAP -0.179057737932812 2.93994721904487e-17 NA NA NA hsa-miR-200c-3p KSR1 2.07038651806183 6.84613386286599e-51 -0.85900089733364 7.21800600691212e-18 mirMAP -0.20351754656324 2.21229417566801e-18 NA NA NA hsa-miR-331-3p KSR1 0.74441480542886 1.17071235477799e-07 -0.85900089733364 7.21800600691212e-18 MirTarget;miRNATAP -0.115469651296313 2.6082959359559e-06 NA NA NA hsa-miR-342-3p KSR1 1.21944481975657 6.81914373001202e-19 -0.85900089733364 7.21800600691212e-18 miRanda -0.178922899667638 3.09769369671935e-13 NA NA NA hsa-miR-429 KSR1 2.84108892259147 3.88520896426515e-64 -0.85900089733364 7.21800600691212e-18 miRanda;mirMAP;miRNATAP -0.159332980084839 3.82878122343549e-17 NA NA NA hsa-miR-92b-3p KSR1 1.30248132773644 9.42428674470985e-25 -0.85900089733364 7.21800600691212e-18 mirMAP -0.146631985709182 3.4344115599242e-08 NA NA NA hsa-miR-106b-5p KSR2 1.22477789913175 2.31787213143326e-32 -0.0859402107200666 0.658608084265407 mirMAP -0.348610177127106 1.60260681197574e-08 NA NA NA hsa-miR-125b-2-3p KSR2 -1.92374904783012 2.30779527653582e-38 -0.0859402107200666 0.658608084265407 mirMAP -0.156191984402813 0.000255989155281545 NA NA NA hsa-miR-130b-5p KSR2 1.0573161199584 2.55177349228739e-12 -0.0859402107200666 0.658608084265407 mirMAP -0.195641490275443 6.49511311003903e-06 NA NA NA hsa-miR-140-5p KSR2 -0.755971041589807 9.68060922934542e-14 -0.0859402107200666 0.658608084265407 mirMAP -0.307784236594514 1.89212252886223e-06 NA NA NA hsa-miR-142-5p KSR2 1.16509303143593 1.96641162209073e-13 -0.0859402107200666 0.658608084265407 mirMAP -0.258742773253564 2.8742726213005e-10 NA NA NA hsa-miR-148a-5p KSR2 0.572692271754695 2.14306251522796e-06 -0.0859402107200666 0.658608084265407 mirMAP -0.156799211861551 0.00431670075868019 NA NA NA hsa-miR-150-5p KSR2 -0.832049526091211 3.45299201139224e-05 -0.0859402107200666 0.658608084265407 mirMAP -0.141323769169874 1.73641558366354e-05 NA NA NA hsa-miR-155-5p KSR2 1.09766314984151 4.55650930885814e-15 -0.0859402107200666 0.658608084265407 mirMAP -0.388161671376663 2.98658834498316e-17 NA NA NA hsa-miR-17-5p KSR2 0.599531757298529 1.07318660415906e-05 -0.0859402107200666 0.658608084265407 mirMAP -0.3357156727324 3.15178162024356e-12 NA NA NA hsa-miR-181a-2-3p KSR2 -0.0718643470098321 0.422077954889554 -0.0859402107200666 0.658608084265407 mirMAP -0.443907023729305 2.34342066539242e-09 NA NA NA hsa-miR-181b-5p KSR2 1.22749257795094 1.21998198830919e-27 -0.0859402107200666 0.658608084265407 mirMAP -0.404168105189449 9.381834487102e-13 NA NA NA hsa-miR-185-5p KSR2 0.482334746589337 3.68475879959415e-09 -0.0859402107200666 0.658608084265407 mirMAP -0.622375441525916 7.80554402833836e-15 NA NA NA hsa-miR-186-5p KSR2 -0.426987301460247 1.04129380549315e-05 -0.0859402107200666 0.658608084265407 mirMAP -0.295624606312176 1.62351081822654e-05 NA NA NA hsa-miR-199a-3p KSR2 -0.174830922802531 0.138748242352612 -0.0859402107200666 0.658608084265407 mirMAP -0.207404576928897 0.000240287368208567 NA NA NA hsa-miR-199b-3p KSR2 -0.173412359075504 0.143232985227463 -0.0859402107200666 0.658608084265407 mirMAP -0.205573259790765 0.000260916145112931 NA NA NA hsa-miR-20a-5p KSR2 0.44979911120222 0.000602386964327228 -0.0859402107200666 0.658608084265407 mirMAP -0.345127584483825 6.03844316860249e-12 NA NA NA hsa-miR-21-5p KSR2 2.32007501846389 3.08394781855554e-137 -0.0859402107200666 0.658608084265407 mirMAP -0.223089579565432 0.000225645228480768 NA NA NA hsa-miR-212-3p KSR2 0.24081906669865 0.0571447155653209 -0.0859402107200666 0.658608084265407 mirMAP;miRNATAP -0.195216303698745 0.000260496842040701 NA NA NA hsa-miR-22-5p KSR2 0.238328801322329 0.0377496760295305 -0.0859402107200666 0.658608084265407 mirMAP -0.408675032471939 1.17155781624574e-12 NA NA NA hsa-miR-223-3p KSR2 -0.966406159689943 7.90612601654887e-12 -0.0859402107200666 0.658608084265407 mirMAP -0.37513075786898 2.57999985323648e-16 NA NA NA hsa-miR-2355-5p KSR2 -0.221733044425126 0.0231054202524677 -0.0859402107200666 0.658608084265407 mirMAP -0.466280732745111 5.88226144061868e-12 NA NA NA hsa-miR-23a-3p KSR2 -0.217176729033818 0.00962615056202409 -0.0859402107200666 0.658608084265407 mirMAP -0.3101861611224 0.000100538087157428 NA NA NA hsa-miR-25-3p KSR2 -0.00546790775985073 0.944061771389468 -0.0859402107200666 0.658608084265407 miRNATAP -0.474127904841252 3.23890618492942e-08 NA NA NA hsa-miR-27b-5p KSR2 0.478244809913032 2.28657237923291e-06 -0.0859402107200666 0.658608084265407 mirMAP -0.346273153278526 1.16917578469738e-07 NA NA NA hsa-miR-29a-5p KSR2 0.334183773952055 0.00445137265870197 -0.0859402107200666 0.658608084265407 mirMAP -0.150343090344496 0.00826664552275475 NA NA NA hsa-miR-324-5p KSR2 0.211552647440779 0.139408130311654 -0.0859402107200666 0.658608084265407 mirMAP -0.131898799992618 0.00464527544665061 NA NA NA hsa-miR-361-3p KSR2 -0.0370446538644886 0.624902392829872 -0.0859402107200666 0.658608084265407 mirMAP -0.397852736519176 6.99985343964537e-06 NA NA NA hsa-miR-374a-3p KSR2 0.34122393953022 2.28714105382856e-05 -0.0859402107200666 0.658608084265407 mirMAP -0.380390401752172 4.20265266400964e-06 NA NA NA hsa-miR-378a-5p KSR2 -2.43173551693523 1.44932837789175e-68 -0.0859402107200666 0.658608084265407 mirMAP -0.384577912006178 4.46444359111333e-19 NA NA NA hsa-miR-381-3p KSR2 -1.28028930293369 1.61402949866141e-23 -0.0859402107200666 0.658608084265407 mirMAP -0.158574988771053 0.00174162776721608 NA NA NA hsa-miR-432-5p KSR2 -1.27705834793565 1.47191322114198e-20 -0.0859402107200666 0.658608084265407 mirMAP -0.127311887174352 0.00747946794105304 NA NA NA hsa-miR-452-5p KSR2 -2.48486455572568 1.24430987974325e-33 -0.0859402107200666 0.658608084265407 mirMAP -0.288941755288498 1.56339993504313e-21 NA NA NA hsa-miR-455-5p KSR2 0.284641224662773 0.0357572339594277 -0.0859402107200666 0.658608084265407 mirMAP -0.359872692441518 1.22983546716084e-13 NA NA NA hsa-miR-485-3p KSR2 -0.866822427729628 4.5194665263492e-11 -0.0859402107200666 0.658608084265407 mirMAP -0.16575656796695 0.00104841537146823 NA NA NA hsa-miR-500a-3p KSR2 0.139523673241448 0.185528510741158 -0.0859402107200666 0.658608084265407 mirMAP -0.710429637847411 3.49376248073296e-31 NA NA NA hsa-miR-505-3p KSR2 -0.530462599544864 7.71645736541597e-05 -0.0859402107200666 0.658608084265407 mirMAP -0.360162495485057 1.6859801987359e-13 NA NA NA hsa-miR-505-5p KSR2 -0.842640534241897 4.43022473091907e-09 -0.0859402107200666 0.658608084265407 mirMAP -0.291666298091564 1.75793654247655e-10 NA NA NA hsa-miR-532-5p KSR2 0.0386976222860582 0.682018574136515 -0.0859402107200666 0.658608084265407 mirMAP -0.72198500164534 1.05753638676968e-25 NA NA NA hsa-miR-589-3p KSR2 0.0263457630961427 0.866577983997705 -0.0859402107200666 0.658608084265407 mirMAP -0.210933572836675 1.12229882574402e-06 NA NA NA hsa-miR-589-5p KSR2 0.367182541239722 1.67804815542873e-05 -0.0859402107200666 0.658608084265407 mirMAP -0.547844724455355 1.38163214900717e-12 NA NA NA hsa-miR-590-3p KSR2 1.27438512890514 1.03164723481469e-23 -0.0859402107200666 0.658608084265407 mirMAP -0.234359462925013 1.0722816165e-05 NA NA NA hsa-miR-590-5p KSR2 0.746515607868274 8.51300479640125e-09 -0.0859402107200666 0.658608084265407 mirMAP -0.320305190138557 2.38396939470611e-10 NA NA NA hsa-miR-92a-3p KSR2 -0.342420481092807 0.000732275969501111 -0.0859402107200666 0.658608084265407 miRNATAP -0.263463291136323 6.01607101445047e-05 NA NA NA hsa-miR-193a-3p LAT 0.310617999804917 0.00477640270974957 0.573089047422622 9.85507014148296e-05 miRanda -0.149249644568495 0.00118535141135911 NA NA NA hsa-miR-101-3p MAP2K1 -0.126035286271986 0.145997832808138 -0.185433389862149 0.000727711407664528 miRNAWalker2_validate -0.158307400181186 2.0108100169932e-13 NA NA NA hsa-miR-181a-5p MAP2K1 0.635863607630183 6.72486918157744e-11 -0.185433389862149 0.000727711407664528 miRNAWalker2_validate -0.103686555340189 5.16890556712928e-08 NA NA NA hsa-miR-361-5p MAP2K1 -0.0996867547900457 0.095428250126326 -0.185433389862149 0.000727711407664528 miRanda -0.121080950243885 0.000149537457617663 NA NA NA hsa-miR-542-3p MAP2K1 0.568822103820889 8.5699075257651e-07 -0.185433389862149 0.000727711407664528 miRanda -0.113613468340007 1.26995828232255e-12 NA NA NA hsa-let-7b-5p MAP2K2 -0.54215483448257 7.21347617597858e-08 0.61941089334837 7.64917587016439e-15 miRNAWalker2_validate -0.171851964586426 2.69292025446759e-10 NA NA NA hsa-miR-29c-3p MAPK1 -0.0652732378039769 0.563774115756922 -0.282469104608855 4.85723866828359e-06 mirMAP -0.107930467813368 8.09848447187363e-09 NA NA NA hsa-miR-361-5p MAPK1 -0.0996867547900457 0.095428250126326 -0.282469104608855 4.85723866828359e-06 PITA;miRanda;mirMAP -0.263780179525808 1.39108568009728e-13 NA NA NA hsa-miR-3913-5p MAPK1 0.71890413546147 2.61153227160465e-13 -0.282469104608855 4.85723866828359e-06 mirMAP -0.145979254174869 5.54224263447113e-12 NA NA NA hsa-miR-660-5p MAPK1 0.406910761707485 0.000156175371762464 -0.282469104608855 4.85723866828359e-06 mirMAP -0.144747929471906 1.05117786154161e-13 NA NA NA hsa-miR-130b-3p MAPK10 1.38122163823846 1.00932179737836e-26 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.311198542431805 1.15998229401123e-08 NA NA NA hsa-miR-19a-3p MAPK10 0.817507952171848 3.76285090469625e-08 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.222702615462015 4.17842244233184e-06 NA NA NA hsa-miR-19b-3p MAPK10 0.139124391010031 0.255658553872934 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.182028621380633 0.00223666160802019 NA NA NA hsa-miR-29b-3p MAPK10 0.438847962603729 6.46722433236121e-05 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.214951327451731 0.00114851870928561 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-301a-3p MAPK10 1.32170168375632 2.12280368957514e-15 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.20354840914367 2.22032173676851e-06 NA NA NA hsa-miR-30d-3p MAPK10 0.264544633563642 0.00755023189129747 -2.40438462003309 4.2516538591888e-32 mirMAP -0.192664485965265 0.00899807954985931 NA NA NA hsa-miR-330-3p MAPK10 0.432728362037032 0.00041335506960812 -2.40438462003309 4.2516538591888e-32 PITA;miRNATAP -0.240537820613709 6.0605250152691e-05 NA NA NA hsa-miR-429 MAPK10 2.84108892259147 3.88520896426515e-64 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.366481358214565 1.02092652001284e-20 NA NA NA hsa-miR-454-3p MAPK10 1.28177672191095 6.84024979484587e-21 -2.40438462003309 4.2516538591888e-32 miRNATAP -0.269274577449595 2.23366460726875e-07 NA NA NA hsa-miR-455-5p MAPK10 0.284641224662773 0.0357572339594277 -2.40438462003309 4.2516538591888e-32 miRanda -0.2052531701295 0.000129116493384105 NA NA NA hsa-miR-590-3p MAPK10 1.27438512890514 1.03164723481469e-23 -2.40438462003309 4.2516538591888e-32 miRanda;mirMAP -0.323164263319335 2.39879463887196e-08 NA NA NA hsa-miR-590-5p MAPK10 0.746515607868274 8.51300479640125e-09 -2.40438462003309 4.2516538591888e-32 PITA;miRanda;miRNATAP -0.208756960356003 0.000174508852265274 NA NA NA hsa-miR-197-3p MAPK3 -0.526589453596294 3.61594599437195e-06 -0.0806112580526674 0.201094437565328 miRNATAP -0.106370513582673 1.47526386613596e-08 NA NA NA hsa-miR-107 MAPK8 0.678998026350662 2.56224148930538e-16 -0.297398434625207 0.00492168724399827 miRNATAP -0.17791631045835 3.75913999690967e-05 NA NA NA hsa-miR-140-3p MAPK8 -1.25844395244141 5.29222651039892e-33 -0.297398434625207 0.00492168724399827 miRNAWalker2_validate -0.18488366577202 2.13922359684877e-08 NA NA NA hsa-miR-214-3p MAPK8 -0.523705501275844 0.000211299789901139 -0.297398434625207 0.00492168724399827 miRNAWalker2_validate -0.131663145030191 2.77448993612092e-07 19859982 HeLa cells that stably overexpress miR-214 downregulate the expression of MEK3 and JNK1 at both mRNA and protein levels; Further investigation revealed that miR-214 regulates the expression of MEK3 and JNK1 by targeting the 3'UTRs of these genes; Collectively these results suggest that miR-214 negatively regulates HeLa cell proliferation by targeting the noncoding regions of MEK3 and JNK1 mRNAs cervical and endocervical cancer hsa-miR-22-5p MAPK8 0.238328801322329 0.0377496760295305 -0.297398434625207 0.00492168724399827 mirMAP -0.111645018994966 0.000421521825972328 NA NA NA hsa-miR-361-5p MAPK8 -0.0996867547900457 0.095428250126326 -0.297398434625207 0.00492168724399827 PITA;miRanda;mirMAP -0.36263548128247 3.21553639920568e-09 NA NA NA hsa-let-7i-5p MAPK9 -0.333419326258177 3.56960810786801e-08 0.291220683716117 6.17961998679004e-06 miRNATAP -0.306833929478603 2.50065627421339e-17 NA NA NA hsa-miR-20a-5p MAPK9 0.44979911120222 0.000602386964327228 0.291220683716117 6.17961998679004e-06 miRNAWalker2_validate;miRNATAP -0.149791797617831 1.16802726117118e-19 NA NA NA hsa-miR-361-5p MAPK9 -0.0996867547900457 0.095428250126326 0.291220683716117 6.17961998679004e-06 miRanda -0.302539307267532 3.19615101156316e-16 NA NA NA hsa-miR-374a-5p MAPK9 -0.239709888246804 0.00309819667153627 0.291220683716117 6.17961998679004e-06 mirMAP -0.208569547789819 1.38505915980085e-14 NA NA NA hsa-miR-374b-5p MAPK9 -0.466781429946153 1.17238311619116e-08 0.291220683716117 6.17961998679004e-06 mirMAP -0.162602292754305 1.32462729456077e-09 NA NA NA hsa-miR-92a-3p MAPK9 -0.342420481092807 0.000732275969501111 0.291220683716117 6.17961998679004e-06 miRNAWalker2_validate -0.159802962706798 1.32672396914361e-13 NA NA NA hsa-miR-30a-5p MET -0.392489994825279 0.00954894667761676 -2.36906628256571 5.79970002931919e-38 miRNAWalker2_validate -0.134503205736039 0.00203853525633078 NA NA NA hsa-miR-34a-5p MET 0.129201805242403 0.133261654068224 -2.36906628256571 5.79970002931919e-38 miRNAWalker2_validate;miRTarBase -0.260533934700572 0.00074892552882336 23243217;26104764;22457788;23593387;19006648;19773441;19029026 Detection of miR 34a promoter methylation in combination with elevated expression of c Met and β catenin predicts distant metastasis of colon cancer; Using a case-control study design of 94 primary colon cancer samples with and without liver metastases we determined CpG methylation frequencies of miR-34a and miR-34b/c promoters expression of miR-34a and its targets c-Met Snail and β-catenin and their prognostic value; Decreased miR-34a expression was associated with upregulation of c-Met Snail and β-catenin protein levels P = 0.031 0.132 and 0.004 which were associated with distant metastases P = 0.001 0.017 and 0.005; In a confounder-adjusted multivariate regression model miR-34a methylation high c-Met and β-catenin levels provided the most significant prognostic information about metastases to the liver P = 0.014 0.031 and 0.058 and matched pairs showed a higher prevalence of these risk factors in the samples with distant spread P = 0.029; Silencing of miR-34a and upregulation of c-Met Snail and β-catenin expression is associated with liver metastases of colon cancer; Detection of miR-34a silencing in resected primary colon cancer may be of prognostic value especially in combination with detection of c-Met and β-catenin expression;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004;c-Met is a target of miR-34a and regulates the migration and invasion of osteosarcoma cells; Osteosarcoma cells over-expressing miR-34a exhibited a significant decrease in the expression levels of c-Met mRNA and protein simultaneously; The results presented in this study demonstrated that over-expression of miR-34a could inhibit the tumor growth and metastasis of osteosarcoma probably through down regulating c-Met; And there are other putative miR-34a target genes beside c-Met which could potentially be key players in the development of osteosarcoma;Underexpression of miR 34a in hepatocellular carcinoma and its contribution towards enhancement of proliferating inhibitory effects of agents targeting c MET; In addition miR-34a mimic enhanced the effect of cell proliferation inhibition and caspase activity induction of agents targeting c-MET siRNAs and small molecular inhibitor su11274;miR 34a inhibits migration and invasion by down regulation of c Met expression in human hepatocellular carcinoma cells; miR-34a directly targeted c-Met and reduced both mRNA and protein levels of c-Met; thus decreased c-Met-induced phosphorylation of extracellular signal-regulated kinases 1 and 2 ERK1/2; Taken together these results provide evidence to show the suppression role of miR-34a in tumor migration and invasion through modulation of the c-Met signaling pathway;miR-34a levels in human gliomas inversely correlated to c-Met levels measured in the same tumors; Forced expression of c-Met or Notch-1/Notch-2 transcripts lacking the 3'-untranslated region sequences partially reversed the effects of miR-34a on cell cycle arrest and cell death in glioma cells and stem cells respectively; They show that miR-34a suppresses brain tumor growth by targeting c-Met and Notch;MicroRNA 34a inhibits uveal melanoma cell proliferation and migration through downregulation of c Met; In addition expression of c-Met and cell cycle-related proteins was determined by Western blotting and immunofluorescence after the introduction of miR-34a miR-34a is actively expressed in melanocytes but not in uveal melanoma cells based on Northern blot analysis; After identification of two putative miR-34a binding sites within the 3' UTR of the human c-Met mRNA miR-34a was shown to suppress luciferase activity using HEK293 cells with a luciferase reporter construct containing the binding sites; miR-34a was confirmed to downregulate the expression of c-Met protein by Western blotting and immunofluorescence; These results demonstrate that miR-34a acts as a tumor suppressor in uveal melanoma cell proliferation and migration through the downregulation of c-Met metastasis;;metastasis;;;; colon cancer;lung cancer;sarcoma;liver cancer;liver cancer;glioblastoma;melanoma hsa-miR-664a-3p MET -0.237699857923843 0.0197071390183375 -2.36906628256571 5.79970002931919e-38 mirMAP -0.177552910041329 0.00637075964459348 NA NA NA hsa-miR-7-1-3p MET 0.686579567507582 1.20731554448806e-07 -2.36906628256571 5.79970002931919e-38 mirMAP -0.239508473942628 2.05545838272513e-06 NA NA NA hsa-let-7e-5p MRAS 0.261471269338985 0.00191077095550257 -2.33160876190743 5.5050134478505e-74 mirMAP -0.192389755360429 0.000819872247169388 NA NA NA hsa-miR-15a-5p MRAS 0.812445324157528 4.50263417099822e-20 -2.33160876190743 5.5050134478505e-74 miRNATAP -0.294536375038997 3.00707532146686e-08 NA NA NA hsa-miR-182-5p MRAS 2.36408084103818 2.60011457600281e-72 -2.33160876190743 5.5050134478505e-74 miRNATAP -0.524902959445825 1.41898946761564e-64 NA NA NA hsa-miR-29b-3p MRAS 0.438847962603729 6.46722433236121e-05 -2.33160876190743 5.5050134478505e-74 mirMAP -0.174910948134691 6.4488306106908e-05 NA NA NA hsa-miR-29c-3p MRAS -0.0652732378039769 0.563774115756922 -2.33160876190743 5.5050134478505e-74 mirMAP -0.272543828832133 1.27963297041164e-10 NA NA NA hsa-miR-3065-3p MRAS 1.62787885002468 6.81477830005026e-19 -2.33160876190743 5.5050134478505e-74 miRNATAP -0.192864005915779 2.71114562092703e-14 NA NA NA hsa-miR-30d-3p MRAS 0.264544633563642 0.00755023189129747 -2.33160876190743 5.5050134478505e-74 mirMAP -0.181655430735092 0.000198117921927286 NA NA NA hsa-miR-342-3p MRAS 1.21944481975657 6.81914373001202e-19 -2.33160876190743 5.5050134478505e-74 mirMAP -0.416322453382336 1.00207978880137e-36 NA NA NA hsa-miR-429 MRAS 2.84108892259147 3.88520896426515e-64 -2.33160876190743 5.5050134478505e-74 miRanda;miRNATAP -0.296364992468048 8.90534224451228e-31 NA NA NA hsa-miR-7-1-3p MRAS 0.686579567507582 1.20731554448806e-07 -2.33160876190743 5.5050134478505e-74 mirMAP -0.200268196549368 4.94694923734357e-08 NA NA NA hsa-miR-96-5p MRAS 3.24596558166606 1.92296159041707e-98 -2.33160876190743 5.5050134478505e-74 TargetScan;miRNATAP -0.416938612016912 1.97469399011339e-58 NA NA NA hsa-miR-103a-3p NF1 0.610673390034345 1.63113920514646e-12 -0.394546709839459 1.88157518863882e-05 MirTarget -0.298258204057073 7.68296810837731e-17 NA NA NA hsa-miR-107 NF1 0.678998026350662 2.56224148930538e-16 -0.394546709839459 1.88157518863882e-05 MirTarget;PITA;miRanda;miRNATAP -0.213773039066899 1.27282989374285e-08 NA NA NA hsa-miR-128-3p NF1 0.90296715955238 9.925204823863e-23 -0.394546709839459 1.88157518863882e-05 MirTarget -0.202019431505486 1.54710819140338e-09 NA NA NA hsa-miR-146b-5p NF1 0.631041661167954 6.20366593452965e-08 -0.394546709839459 1.88157518863882e-05 miRanda -0.199151597034007 8.6341967962311e-14 NA NA NA hsa-miR-148a-5p NF1 0.572692271754695 2.14306251522796e-06 -0.394546709839459 1.88157518863882e-05 MirTarget -0.175869814732318 1.05874103404454e-11 NA NA NA hsa-miR-15a-5p NF1 0.812445324157528 4.50263417099822e-20 -0.394546709839459 1.88157518863882e-05 MirTarget -0.308769926485221 3.26409823531366e-19 NA NA NA hsa-miR-16-1-3p NF1 1.30142784811196 2.53343713753744e-29 -0.394546709839459 1.88157518863882e-05 MirTarget -0.106075229157645 0.000154108549001089 NA NA NA hsa-miR-27a-3p NF1 0.388496361379095 1.42373532086331e-05 -0.394546709839459 1.88157518863882e-05 MirTarget -0.181895208507095 2.5659715334711e-07 NA NA NA hsa-miR-27b-3p NF1 -0.0796803270437447 0.410503155574393 -0.394546709839459 1.88157518863882e-05 MirTarget -0.109344267200185 0.000896087377699338 NA NA NA hsa-miR-340-5p NF1 1.0857159627596 4.94471062546756e-24 -0.394546709839459 1.88157518863882e-05 mirMAP -0.253924743873191 2.1923712592731e-19 NA NA NA hsa-miR-361-5p NF1 -0.0996867547900457 0.095428250126326 -0.394546709839459 1.88157518863882e-05 miRanda -0.427396849502152 8.30070228967362e-16 NA NA NA hsa-miR-362-5p NF1 -0.248676340901797 0.0726089851456282 -0.394546709839459 1.88157518863882e-05 mirMAP -0.163315496679587 5.33921764267452e-13 NA NA NA hsa-miR-455-5p NF1 0.284641224662773 0.0357572339594277 -0.394546709839459 1.88157518863882e-05 miRanda -0.202769455211226 1.03483221954599e-18 NA NA NA hsa-let-7d-5p NGF 0.410958462607207 6.07808182756787e-06 -0.787725123054401 9.35669050853888e-08 MirTarget -0.171326999284145 0.00225973911147285 NA NA NA hsa-miR-429 NGF 2.84108892259147 3.88520896426515e-64 -0.787725123054401 9.35669050853888e-08 miRanda -0.12206490353919 1.36541405382157e-05 NA NA NA hsa-miR-15b-3p NGFR 1.12898579025388 1.18050912917317e-14 -2.50042294481334 5.32154099004444e-27 mirMAP -0.662442871026151 9.19146915678377e-36 NA NA NA hsa-miR-185-3p NGFR 0.86591374114446 7.8790769678542e-10 -2.50042294481334 5.32154099004444e-27 miRNATAP -0.558631835952441 2.12953197650633e-22 NA NA NA hsa-miR-193a-3p NGFR 0.310617999804917 0.00477640270974957 -2.50042294481334 5.32154099004444e-27 miRanda -0.520708123872055 1.99092128302359e-12 NA NA NA hsa-miR-27a-3p NGFR 0.388496361379095 1.42373532086331e-05 -2.50042294481334 5.32154099004444e-27 miRNATAP -0.439062106500076 1.68928439077992e-06 NA NA NA hsa-miR-30b-3p NGFR -0.536462824497982 2.41814659272548e-05 -2.50042294481334 5.32154099004444e-27 mirMAP -0.305652864637524 2.34744572510331e-06 NA NA NA hsa-miR-324-5p NGFR 0.211552647440779 0.139408130311654 -2.50042294481334 5.32154099004444e-27 miRanda -0.552743690537487 6.69210223218312e-23 NA NA NA hsa-miR-330-5p NGFR 0.626063225953928 3.42215028606779e-09 -2.50042294481334 5.32154099004444e-27 miRanda;mirMAP;miRNATAP -0.663548277903429 1.91996593924222e-18 NA NA NA hsa-miR-342-5p NGFR 1.49554286219821 1.56221300255782e-22 -2.50042294481334 5.32154099004444e-27 mirMAP -0.37697123789083 2.96787913045429e-13 NA NA NA hsa-miR-34a-5p NGFR 0.129201805242403 0.133261654068224 -2.50042294481334 5.32154099004444e-27 mirMAP -0.493588136203429 2.5977817562076e-07 NA NA NA hsa-miR-429 NGFR 2.84108892259147 3.88520896426515e-64 -2.50042294481334 5.32154099004444e-27 miRNATAP -0.365440513479821 3.03625910927681e-16 NA NA NA hsa-miR-625-5p NGFR 0.728939236913178 5.97591217674307e-08 -2.50042294481334 5.32154099004444e-27 mirMAP -0.290398887460611 3.44867089710813e-06 NA NA NA hsa-miR-766-3p NGFR 0.496790679032227 8.22686414022553e-05 -2.50042294481334 5.32154099004444e-27 mirMAP -0.45318423386739 1.88340574844031e-12 NA NA NA hsa-miR-26a-5p NRAS -0.481180084102235 1.82368246174758e-10 0.183758021967058 0.0269071454303856 mirMAP;miRNATAP -0.171830491303475 4.57786379954293e-06 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-29a-3p NRAS -0.699539666833076 1.13935003139957e-13 0.183758021967058 0.0269071454303856 miRNATAP -0.131093968344875 1.07589675767432e-05 NA NA NA hsa-miR-29c-3p NRAS -0.0652732378039769 0.563774115756922 0.183758021967058 0.0269071454303856 miRNATAP -0.211489064949879 1.38049039033829e-17 NA NA NA hsa-miR-381-3p NRAS -1.28028930293369 1.61402949866141e-23 0.183758021967058 0.0269071454303856 mirMAP -0.110038347690747 3.16999123322707e-07 NA NA NA hsa-miR-142-3p NTF3 1.53951237846104 2.06769936282034e-17 -2.35193065681614 1.75397805257351e-24 miRanda -0.25559087299935 4.55546500058392e-09 NA NA NA hsa-miR-200b-3p NTF3 2.11744072703209 1.66710572104191e-43 -2.35193065681614 1.75397805257351e-24 TargetScan -0.321874947951398 1.05323715646676e-10 NA NA NA hsa-miR-200c-3p NTF3 2.07038651806183 6.84613386286599e-51 -2.35193065681614 1.75397805257351e-24 miRNAWalker2_validate;miRNATAP -0.405535845133949 1.08735324650309e-13 NA NA NA hsa-miR-21-5p NTF3 2.32007501846389 3.08394781855554e-137 -2.35193065681614 1.75397805257351e-24 miRTarBase;miRNATAP -0.481266108265449 4.86045305948914e-11 NA NA NA hsa-miR-429 NTF3 2.84108892259147 3.88520896426515e-64 -2.35193065681614 1.75397805257351e-24 PITA;miRanda;miRNATAP -0.318352061640753 7.25173081695566e-13 NA NA NA hsa-miR-590-3p NTF3 1.27438512890514 1.03164723481469e-23 -2.35193065681614 1.75397805257351e-24 miRanda -0.327104104078733 4.60676593188325e-07 NA NA NA hsa-miR-590-5p NTF3 0.746515607868274 8.51300479640125e-09 -2.35193065681614 1.75397805257351e-24 PITA;miRanda;miRNATAP -0.249639896667382 5.92923109438771e-05 NA NA NA hsa-miR-107 NTRK2 0.678998026350662 2.56224148930538e-16 -4.03565225718056 9.2986992242195e-64 PITA;miRanda -0.836390405916991 1.12926053720617e-15 NA NA NA hsa-miR-130b-3p NTRK2 1.38122163823846 1.00932179737836e-26 -4.03565225718056 9.2986992242195e-64 mirMAP -0.769347321078169 1.17967706482035e-32 NA NA NA hsa-miR-130b-5p NTRK2 1.0573161199584 2.55177349228739e-12 -4.03565225718056 9.2986992242195e-64 mirMAP -0.488025092950443 1.17958520925326e-17 NA NA NA hsa-miR-142-3p NTRK2 1.53951237846104 2.06769936282034e-17 -4.03565225718056 9.2986992242195e-64 miRanda -0.311735989864694 5.64944316358857e-11 NA NA NA hsa-miR-142-5p NTRK2 1.16509303143593 1.96641162209073e-13 -4.03565225718056 9.2986992242195e-64 mirMAP -0.267780450784351 1.15450126012637e-06 NA NA NA hsa-miR-146b-5p NTRK2 0.631041661167954 6.20366593452965e-08 -4.03565225718056 9.2986992242195e-64 PITA;miRanda -0.314474616023657 3.27685992622639e-05 NA NA NA hsa-miR-148a-5p NTRK2 0.572692271754695 2.14306251522796e-06 -4.03565225718056 9.2986992242195e-64 mirMAP -0.198050799697867 0.00696218497554125 NA NA NA hsa-miR-151a-5p NTRK2 0.509210376738198 3.17540030607215e-07 -4.03565225718056 9.2986992242195e-64 miRNATAP -0.780564562612712 3.70349058685946e-19 NA NA NA hsa-miR-155-5p NTRK2 1.09766314984151 4.55650930885814e-15 -4.03565225718056 9.2986992242195e-64 mirMAP -0.41539155563853 1.85377330452013e-11 NA NA NA hsa-miR-15b-3p NTRK2 1.12898579025388 1.18050912917317e-14 -4.03565225718056 9.2986992242195e-64 mirMAP -0.562890529553338 5.4599239852998e-22 NA NA NA hsa-miR-17-3p NTRK2 0.721439431208839 7.95900548819742e-10 -4.03565225718056 9.2986992242195e-64 miRNATAP -0.45111098908225 1.45919732139291e-09 NA NA NA hsa-miR-181a-5p NTRK2 0.635863607630183 6.72486918157744e-11 -4.03565225718056 9.2986992242195e-64 mirMAP -0.680395100851069 2.6766742709822e-14 NA NA NA hsa-miR-181b-5p NTRK2 1.22749257795094 1.21998198830919e-27 -4.03565225718056 9.2986992242195e-64 mirMAP -0.779842929679368 9.18504195603619e-26 NA NA NA hsa-miR-182-5p NTRK2 2.36408084103818 2.60011457600281e-72 -4.03565225718056 9.2986992242195e-64 mirMAP -0.570548474380832 3.49801193738836e-21 NA NA NA hsa-miR-185-5p NTRK2 0.482334746589337 3.68475879959415e-09 -4.03565225718056 9.2986992242195e-64 mirMAP -0.870491482821692 3.554861973461e-16 NA NA NA hsa-miR-200c-3p NTRK2 2.07038651806183 6.84613386286599e-51 -4.03565225718056 9.2986992242195e-64 miRNAWalker2_validate;miRTarBase -0.540459062838814 7.12630091174492e-20 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-21-5p NTRK2 2.32007501846389 3.08394781855554e-137 -4.03565225718056 9.2986992242195e-64 mirMAP -1.20592530757402 1.06429280476928e-57 NA NA NA hsa-miR-27b-5p NTRK2 0.478244809913032 2.28657237923291e-06 -4.03565225718056 9.2986992242195e-64 mirMAP -0.459936572788305 1.37095676083519e-07 NA NA NA hsa-miR-301a-3p NTRK2 1.32170168375632 2.12280368957514e-15 -4.03565225718056 9.2986992242195e-64 mirMAP -0.591414503280674 3.56317078452758e-31 NA NA NA hsa-miR-32-5p NTRK2 1.38676603945192 2.29428299685976e-34 -4.03565225718056 9.2986992242195e-64 mirMAP -0.661395204008918 3.13696590151528e-19 NA NA NA hsa-miR-330-5p NTRK2 0.626063225953928 3.42215028606779e-09 -4.03565225718056 9.2986992242195e-64 miRanda -0.478715290991117 7.66297627939398e-09 NA NA NA hsa-miR-33a-5p NTRK2 1.35185127289399 9.80509199125785e-12 -4.03565225718056 9.2986992242195e-64 mirMAP -0.330110530234138 1.17990045018443e-13 NA NA NA hsa-miR-340-5p NTRK2 1.0857159627596 4.94471062546756e-24 -4.03565225718056 9.2986992242195e-64 mirMAP -0.658186289275308 1.12023703246196e-16 NA NA NA hsa-miR-342-3p NTRK2 1.21944481975657 6.81914373001202e-19 -4.03565225718056 9.2986992242195e-64 miRanda -0.259575565229622 4.07249780461087e-05 NA NA NA hsa-miR-362-5p NTRK2 -0.248676340901797 0.0726089851456282 -4.03565225718056 9.2986992242195e-64 mirMAP -0.211021259711251 0.00102124609335382 NA NA NA hsa-miR-429 NTRK2 2.84108892259147 3.88520896426515e-64 -4.03565225718056 9.2986992242195e-64 PITA;miRanda;miRNATAP -0.51698534306774 1.82175500468262e-27 NA NA NA hsa-miR-454-3p NTRK2 1.28177672191095 6.84024979484587e-21 -4.03565225718056 9.2986992242195e-64 mirMAP -0.612915092365335 8.08891527812014e-23 NA NA NA hsa-miR-455-3p NTRK2 0.678392920628872 0.000327758844555877 -4.03565225718056 9.2986992242195e-64 mirMAP -0.199163639140476 2.0930591380016e-05 NA NA NA hsa-miR-532-5p NTRK2 0.0386976222860582 0.682018574136515 -4.03565225718056 9.2986992242195e-64 PITA -0.521210748289278 3.09260110111958e-08 NA NA NA hsa-miR-576-5p NTRK2 0.0649387707567879 0.588791966096287 -4.03565225718056 9.2986992242195e-64 PITA;mirMAP -0.278348766635835 0.000174544446483956 NA NA NA hsa-miR-590-3p NTRK2 1.27438512890514 1.03164723481469e-23 -4.03565225718056 9.2986992242195e-64 PITA;miRanda;mirMAP -0.630708695964853 1.65227664250245e-19 NA NA NA hsa-miR-590-5p NTRK2 0.746515607868274 8.51300479640125e-09 -4.03565225718056 9.2986992242195e-64 miRanda;mirMAP -0.533409974311982 1.82799161345103e-15 NA NA NA hsa-let-7i-5p PAK1 -0.333419326258177 3.56960810786801e-08 0.689577121383134 3.29086569405593e-11 miRNATAP -0.205590450324816 0.000613477641577343 NA NA NA hsa-miR-199a-3p PAK1 -0.174830922802531 0.138748242352612 0.689577121383134 3.29086569405593e-11 PITA -0.112484835583981 0.000232116385033466 NA NA NA hsa-miR-199a-5p PAK1 -0.314703593105081 0.00909304983051124 0.689577121383134 3.29086569405593e-11 miRanda -0.141163072158186 2.14274398700042e-06 NA NA NA hsa-miR-199b-3p PAK1 -0.173412359075504 0.143232985227463 0.689577121383134 3.29086569405593e-11 PITA -0.111647781149534 0.000247102113603849 NA NA NA hsa-miR-199b-5p PAK1 -1.37022396448377 3.25758057539223e-26 0.689577121383134 3.29086569405593e-11 miRanda -0.172814671194024 1.07117680121655e-10 NA NA NA hsa-miR-140-3p PAK2 -1.25844395244141 5.29222651039892e-33 0.161029955747728 0.0079135487503 MirTarget;PITA;miRNATAP -0.178278329352708 7.31154043475859e-22 NA NA NA hsa-miR-26a-5p PAK2 -0.481180084102235 1.82368246174758e-10 0.161029955747728 0.0079135487503 MirTarget;miRNATAP -0.187919188954162 4.38967274156601e-12 NA NA NA hsa-miR-361-5p PAK2 -0.0996867547900457 0.095428250126326 0.161029955747728 0.0079135487503 mirMAP -0.202229020706329 8.03135763719411e-09 NA NA NA hsa-miR-107 PAK3 0.678998026350662 2.56224148930538e-16 -3.72979901479568 2.02151045164573e-57 miRanda -0.580679015129187 1.22902331553792e-08 NA NA NA hsa-miR-149-5p PAK3 0.218233101703391 0.261629158371175 -3.72979901479568 2.02151045164573e-57 MirTarget;miRNATAP -0.249644454262038 1.35331713343408e-08 NA NA NA hsa-miR-200b-3p PAK3 2.11744072703209 1.66710572104191e-43 -3.72979901479568 2.02151045164573e-57 TargetScan -0.377458116576707 7.1482577050122e-13 NA NA NA hsa-miR-200c-5p PAK3 1.72523090857052 4.04399802119594e-33 -3.72979901479568 2.02151045164573e-57 MirTarget;miRNATAP -0.245430120931968 3.25421403807253e-05 NA NA NA hsa-miR-590-3p PAK3 1.27438512890514 1.03164723481469e-23 -3.72979901479568 2.02151045164573e-57 miRanda -0.252083823850284 0.000254250222219968 NA NA NA hsa-miR-664a-3p PAK3 -0.237699857923843 0.0197071390183375 -3.72979901479568 2.02151045164573e-57 MirTarget -0.2589599087295 0.00223556821387946 NA NA NA hsa-miR-96-5p PAK3 3.24596558166606 1.92296159041707e-98 -3.72979901479568 2.02151045164573e-57 TargetScan -0.678741357461716 1.34911750627433e-47 NA NA NA hsa-let-7c-5p PAK4 -1.9415540533505 9.55250745007793e-48 1.47186288644382 7.37718156197043e-58 miRNAWalker2_validate -0.215515059875782 2.37391273564343e-20 NA NA NA hsa-miR-145-5p PAK4 -2.62703571936687 7.64402900188551e-88 1.47186288644382 7.37718156197043e-58 miRNAWalker2_validate;miRTarBase -0.326408303596423 4.52801469396177e-52 23499891 We further demonstrated that miR-145 directly targeted catenin δ-1 contributing to the aberrant translocation of β-catenin through impaired nuclear shuttling with p21-activated kinase 4 PAK4 colon cancer hsa-miR-199a-3p PAK4 -0.174830922802531 0.138748242352612 1.47186288644382 7.37718156197043e-58 PITA;miRNATAP -0.205429073030971 4.27171238104975e-13 NA NA NA hsa-miR-199b-3p PAK4 -0.173412359075504 0.143232985227463 1.47186288644382 7.37718156197043e-58 PITA;miRNATAP -0.205050625787072 3.97351210030026e-13 NA NA NA hsa-miR-24-3p PAK4 -0.120123317289941 0.21432376743243 1.47186288644382 7.37718156197043e-58 miRNAWalker2_validate;miRNATAP -0.193042798351558 3.2440565929386e-08 NA NA NA hsa-miR-215-5p PAK6 -1.35643065897947 2.3180023440257e-20 0.720147532475893 5.40787365591122e-06 miRNAWalker2_validate -0.146640123931798 5.42882437353316e-05 NA NA NA hsa-miR-484 PAK6 0.349444060004737 0.00154491249625173 0.720147532475893 5.40787365591122e-06 mirMAP -0.130050923616182 0.00860407924290804 NA NA NA hsa-let-7d-5p PDGFA 0.410958462607207 6.07808182756787e-06 -1.03194821362155 2.98319775634862e-27 miRNAWalker2_validate -0.111085037882515 0.0028367772618075 NA NA NA hsa-miR-331-5p PDGFA 0.682437632502949 4.10871642662371e-11 -1.03194821362155 2.98319775634862e-27 PITA;miRNATAP -0.22667510028007 1.7281960179029e-12 NA NA NA hsa-miR-484 PDGFA 0.349444060004737 0.00154491249625173 -1.03194821362155 2.98319775634862e-27 PITA;miRNATAP -0.214059857890823 1.54568697231701e-12 NA NA NA hsa-miR-590-3p PDGFA 1.27438512890514 1.03164723481469e-23 -1.03194821362155 2.98319775634862e-27 miRanda -0.165100330465473 7.8988455074446e-10 NA NA NA hsa-miR-590-5p PDGFA 0.746515607868274 8.51300479640125e-09 -1.03194821362155 2.98319775634862e-27 miRanda -0.119998279179232 3.27111011320567e-06 NA NA NA hsa-let-7d-5p PDGFB 0.410958462607207 6.07808182756787e-06 0.0445377066563912 0.601024636333503 miRNATAP -0.127460924180761 6.8859001946812e-05 NA NA NA hsa-let-7g-5p PDGFB 0.0200025784917734 0.791635298815256 0.0445377066563912 0.601024636333503 miRNATAP -0.148185313332358 0.000134872450400757 NA NA NA hsa-let-7i-5p PDGFB -0.333419326258177 3.56960810786801e-08 0.0445377066563912 0.601024636333503 miRNATAP -0.131426457663067 0.00682130071674743 NA NA NA hsa-miR-146b-3p PDGFB -0.260891807886908 0.0211838235241739 0.0445377066563912 0.601024636333503 miRNAWalker2_validate -0.113394049081063 1.0320398497476e-05 NA NA NA hsa-miR-17-5p PDGFB 0.599531757298529 1.07318660415906e-05 0.0445377066563912 0.601024636333503 TargetScan -0.107407253083859 4.08751757932673e-07 NA NA NA hsa-miR-29a-3p PDGFB -0.699539666833076 1.13935003139957e-13 0.0445377066563912 0.601024636333503 MirTarget;miRNATAP -0.128475198337676 2.5654295496112e-05 NA NA NA hsa-let-7a-3p PDGFC 0.466622567891891 3.70886257943079e-07 -0.978440727200944 8.9591213400997e-19 mirMAP -0.130143500695485 0.00200973229404423 NA NA NA hsa-miR-142-5p PDGFC 1.16509303143593 1.96641162209073e-13 -0.978440727200944 8.9591213400997e-19 PITA -0.16246211089026 8.90808371952716e-12 NA NA NA hsa-miR-16-2-3p PDGFC 0.286355254959005 0.0256946046884474 -0.978440727200944 8.9591213400997e-19 mirMAP -0.200678062147313 2.53333168647401e-11 NA NA NA hsa-miR-330-3p PDGFC 0.432728362037032 0.00041335506960812 -0.978440727200944 8.9591213400997e-19 mirMAP -0.203742285211782 1.32009888968262e-10 NA NA NA hsa-miR-330-5p PDGFC 0.626063225953928 3.42215028606779e-09 -0.978440727200944 8.9591213400997e-19 miRanda -0.252272874306445 2.15422319075801e-12 NA NA NA hsa-miR-340-5p PDGFC 1.0857159627596 4.94471062546756e-24 -0.978440727200944 8.9591213400997e-19 mirMAP -0.314553890954425 6.17997923484242e-20 NA NA NA hsa-miR-361-5p PDGFC -0.0996867547900457 0.095428250126326 -0.978440727200944 8.9591213400997e-19 miRanda -0.318946471741077 1.16865088583823e-06 NA NA NA hsa-miR-374a-3p PDGFC 0.34122393953022 2.28714105382856e-05 -0.978440727200944 8.9591213400997e-19 mirMAP -0.226510946292756 2.43085641584885e-06 NA NA NA hsa-miR-590-3p PDGFC 1.27438512890514 1.03164723481469e-23 -0.978440727200944 8.9591213400997e-19 PITA;miRanda;mirMAP -0.277327179688994 6.90970581985756e-20 NA NA NA hsa-miR-7-1-3p PDGFC 0.686579567507582 1.20731554448806e-07 -0.978440727200944 8.9591213400997e-19 mirMAP -0.116839921632248 7.99328092215278e-05 NA NA NA hsa-miR-125a-3p PDGFD -0.176412960953959 0.10108079286419 -2.17788738091168 7.06207148591019e-60 miRanda -0.119583380809276 0.00952184976958956 NA NA NA hsa-miR-19b-1-5p PDGFD 0.647704962003062 3.07687667945597e-07 -2.17788738091168 7.06207148591019e-60 MirTarget -0.438124514443653 9.84221523032561e-32 NA NA NA hsa-miR-203a-3p PDGFD 1.67084394806148 6.06522273352132e-14 -2.17788738091168 7.06207148591019e-60 MirTarget -0.178881432965936 6.3979976925553e-17 NA NA NA hsa-miR-21-5p PDGFD 2.32007501846389 3.08394781855554e-137 -2.17788738091168 7.06207148591019e-60 miRNAWalker2_validate -0.58246612445279 1.38968424696146e-42 NA NA NA hsa-miR-320b PDGFD 0.412787504747938 0.00113457276903985 -2.17788738091168 7.06207148591019e-60 miRanda -0.234603273416289 1.42000791647672e-09 NA NA NA hsa-miR-330-3p PDGFD 0.432728362037032 0.00041335506960812 -2.17788738091168 7.06207148591019e-60 MirTarget;PITA -0.186433075255229 4.45712214549411e-06 NA NA NA hsa-miR-331-5p PDGFD 0.682437632502949 4.10871642662371e-11 -2.17788738091168 7.06207148591019e-60 MirTarget -0.44396123572881 9.47659812594788e-22 NA NA NA hsa-miR-590-3p PDGFD 1.27438512890514 1.03164723481469e-23 -2.17788738091168 7.06207148591019e-60 miRanda;mirMAP;miRNATAP -0.499606568060295 3.79285218268692e-40 NA NA NA hsa-miR-590-5p PDGFD 0.746515607868274 8.51300479640125e-09 -2.17788738091168 7.06207148591019e-60 miRanda -0.454069225558139 4.11350350024471e-36 NA NA NA hsa-miR-7-1-3p PDGFD 0.686579567507582 1.20731554448806e-07 -2.17788738091168 7.06207148591019e-60 mirMAP -0.179504767545686 1.85513561254515e-06 NA NA NA hsa-miR-9-5p PDGFD 0.734772328078424 0.00261982843636383 -2.17788738091168 7.06207148591019e-60 MirTarget -0.16906539909882 1.1572662105982e-17 NA NA NA hsa-let-7a-3p PDGFRA 0.466622567891891 3.70886257943079e-07 -1.84169721584144 2.50038285124215e-31 mirMAP -0.329460092115081 6.44888590147222e-08 NA NA NA hsa-miR-106a-5p PDGFRA 0.574594373206545 0.000145868284001732 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.114055302211927 0.0021406545639755 NA NA NA hsa-miR-106b-5p PDGFRA 1.22477789913175 2.31787213143326e-32 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.488023399387153 1.85919087848084e-21 NA NA NA hsa-miR-130b-3p PDGFRA 1.38122163823846 1.00932179737836e-26 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.205861486268687 1.18866735754345e-06 NA NA NA hsa-miR-141-3p PDGFRA 2.99777540204168 1.26370498493024e-78 -1.84169721584144 2.50038285124215e-31 MirTarget -0.465703815469129 7.78017639246501e-55 NA NA NA hsa-miR-149-5p PDGFRA 0.218233101703391 0.261629158371175 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.10186586746034 0.000432641759044271 NA NA NA hsa-miR-16-1-3p PDGFRA 1.30142784811196 2.53343713753744e-29 -1.84169721584144 2.50038285124215e-31 MirTarget -0.445034147047717 7.48526207581866e-20 NA NA NA hsa-miR-17-5p PDGFRA 0.599531757298529 1.07318660415906e-05 -1.84169721584144 2.50038285124215e-31 MirTarget;TargetScan;miRNATAP -0.230385311598016 1.83020228188668e-08 NA NA NA hsa-miR-181b-5p PDGFRA 1.22749257795094 1.21998198830919e-27 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.19733318786805 4.51362347726677e-05 NA NA NA hsa-miR-181c-5p PDGFRA 0.574847839298605 4.51287502066478e-07 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.199505884862497 4.93594812999378e-05 NA NA NA hsa-miR-181d-5p PDGFRA 0.782618466877349 1.2821116358212e-09 -1.84169721584144 2.50038285124215e-31 MirTarget -0.209000657310327 1.2726595161397e-06 NA NA NA hsa-miR-182-5p PDGFRA 2.36408084103818 2.60011457600281e-72 -1.84169721584144 2.50038285124215e-31 miRNATAP -0.488133036134936 5.32981617385656e-39 NA NA NA hsa-miR-193a-3p PDGFRA 0.310617999804917 0.00477640270974957 -1.84169721584144 2.50038285124215e-31 miRanda -0.236933469215575 3.5076412689528e-06 NA NA NA hsa-miR-200a-3p PDGFRA 2.55218480823434 2.96135446816238e-51 -1.84169721584144 2.50038285124215e-31 MirTarget -0.404359885272289 5.76229938736958e-42 NA NA NA hsa-miR-20a-5p PDGFRA 0.44979911120222 0.000602386964327228 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.252447130222501 3.08338747587722e-09 NA NA NA hsa-miR-20b-5p PDGFRA 0.78236583455125 8.7938334801223e-05 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.120554127383801 1.73060256254725e-05 NA NA NA hsa-miR-29b-2-5p PDGFRA -0.263499971180298 0.0400001755611965 -1.84169721584144 2.50038285124215e-31 mirMAP -0.308292211262466 1.26968663702118e-12 NA NA NA hsa-miR-29b-3p PDGFRA 0.438847962603729 6.46722433236121e-05 -1.84169721584144 2.50038285124215e-31 MirTarget -0.500389516534886 1.15065170563473e-23 NA NA NA hsa-miR-29c-3p PDGFRA -0.0652732378039769 0.563774115756922 -1.84169721584144 2.50038285124215e-31 MirTarget -0.350109088283135 1.37340184176404e-12 NA NA NA hsa-miR-301a-3p PDGFRA 1.32170168375632 2.12280368957514e-15 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.255990348992222 8.11143570915912e-15 NA NA NA hsa-miR-320b PDGFRA 0.412787504747938 0.00113457276903985 -1.84169721584144 2.50038285124215e-31 miRanda -0.183733564050286 3.69207458785768e-05 NA NA NA hsa-miR-330-5p PDGFRA 0.626063225953928 3.42215028606779e-09 -1.84169721584144 2.50038285124215e-31 miRanda -0.192776801359275 0.000261739400977773 NA NA NA hsa-miR-338-3p PDGFRA 0.0799903526884966 0.575137668326679 -1.84169721584144 2.50038285124215e-31 miRanda -0.319924077772208 1.84779948590881e-16 NA NA NA hsa-miR-339-5p PDGFRA -0.211548290465418 0.0685885445822389 -1.84169721584144 2.50038285124215e-31 miRanda -0.18956471906179 9.38243938310758e-05 NA NA NA hsa-miR-33a-5p PDGFRA 1.35185127289399 9.80509199125785e-12 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.153487879078261 6.47868493614725e-08 NA NA NA hsa-miR-342-3p PDGFRA 1.21944481975657 6.81914373001202e-19 -1.84169721584144 2.50038285124215e-31 MirTarget;miRanda;miRNATAP -0.370862046281642 3.2391388940783e-21 NA NA NA hsa-miR-34a-5p PDGFRA 0.129201805242403 0.133261654068224 -1.84169721584144 2.50038285124215e-31 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.257308196495663 9.23678964579895e-05 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-429 PDGFRA 2.84108892259147 3.88520896426515e-64 -1.84169721584144 2.50038285124215e-31 miRanda;miRNATAP -0.373691764862624 4.97896969778458e-36 NA NA NA hsa-miR-454-3p PDGFRA 1.28177672191095 6.84024979484587e-21 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.35092972448673 9.46773059007511e-19 NA NA NA hsa-miR-590-3p PDGFRA 1.27438512890514 1.03164723481469e-23 -1.84169721584144 2.50038285124215e-31 miRanda;mirMAP -0.264364229545702 3.69842178603011e-09 NA NA NA hsa-miR-590-5p PDGFRA 0.746515607868274 8.51300479640125e-09 -1.84169721584144 2.50038285124215e-31 miRanda -0.212109048295796 7.97276608700393e-07 NA NA NA hsa-miR-664a-3p PDGFRA -0.237699857923843 0.0197071390183375 -1.84169721584144 2.50038285124215e-31 mirMAP -0.180157525965088 0.00115407518602231 NA NA NA hsa-miR-7-1-3p PDGFRA 0.686579567507582 1.20731554448806e-07 -1.84169721584144 2.50038285124215e-31 mirMAP -0.307956291240907 5.06202621843896e-13 NA NA NA hsa-miR-93-5p PDGFRA 1.01788600209314 1.24312921618126e-21 -1.84169721584144 2.50038285124215e-31 MirTarget;miRNATAP -0.499449521835939 3.61616920956413e-23 NA NA NA hsa-miR-96-5p PDGFRA 3.24596558166606 1.92296159041707e-98 -1.84169721584144 2.50038285124215e-31 TargetScan;miRNATAP -0.477431215706839 8.10828261241382e-56 NA NA NA hsa-miR-29a-3p PDGFRB -0.699539666833076 1.13935003139957e-13 -0.363053423609744 0.000930448280520273 miRNATAP -0.173489965488495 1.08203138499797e-05 NA NA NA hsa-miR-29b-3p PDGFRB 0.438847962603729 6.46722433236121e-05 -0.363053423609744 0.000930448280520273 miRNATAP -0.37404884670886 1.21864334087282e-29 NA NA NA hsa-miR-29c-3p PDGFRB -0.0652732378039769 0.563774115756922 -0.363053423609744 0.000930448280520273 miRNATAP -0.131693600188518 7.8570505856864e-05 NA NA NA hsa-miR-3127-5p PDGFRB 0.903405128081314 1.1325923598273e-12 -0.363053423609744 0.000930448280520273 mirMAP -0.190856341471899 4.71469241759899e-11 NA NA NA hsa-miR-338-3p PDGFRB 0.0799903526884966 0.575137668326679 -0.363053423609744 0.000930448280520273 miRanda -0.135507787608143 2.53645768220537e-07 NA NA NA hsa-miR-342-3p PDGFRB 1.21944481975657 6.81914373001202e-19 -0.363053423609744 0.000930448280520273 miRanda -0.120554527834238 6.56852598546147e-06 NA NA NA hsa-miR-361-3p PDGFRB -0.0370446538644886 0.624902392829872 -0.363053423609744 0.000930448280520273 MirTarget -0.332024100699143 2.34711270011442e-11 NA NA NA hsa-miR-484 PDGFRB 0.349444060004737 0.00154491249625173 -0.363053423609744 0.000930448280520273 mirMAP -0.17421282482312 2.9286066688125e-07 NA NA NA hsa-miR-664a-3p PDGFRB -0.237699857923843 0.0197071390183375 -0.363053423609744 0.000930448280520273 MirTarget -0.173222382702463 2.70287047774181e-06 NA NA NA hsa-miR-142-3p PGF 1.53951237846104 2.06769936282034e-17 0.187603779609442 0.0921943717527187 miRanda -0.110153556627631 7.64442465753915e-08 NA NA NA hsa-miR-326 PGF -1.54449030848141 1.04703417845594e-17 0.187603779609442 0.0921943717527187 mirMAP -0.12535880272214 1.12977476405779e-09 NA NA NA hsa-miR-330-5p PGF 0.626063225953928 3.42215028606779e-09 0.187603779609442 0.0921943717527187 mirMAP -0.169384385810917 2.04633751679976e-06 NA NA NA hsa-miR-766-3p PGF 0.496790679032227 8.22686414022553e-05 0.187603779609442 0.0921943717527187 MirTarget -0.149878694548497 6.09352519262623e-07 NA NA NA hsa-miR-146b-5p PIK3CA 0.631041661167954 6.20366593452965e-08 -0.881957552231161 1.15529457057533e-22 mirMAP -0.10172531442561 0.000163300940659646 NA NA NA hsa-miR-148a-5p PIK3CA 0.572692271754695 2.14306251522796e-06 -0.881957552231161 1.15529457057533e-22 mirMAP -0.111623090383025 1.82115916734019e-05 NA NA NA hsa-miR-200b-3p PIK3CA 2.11744072703209 1.66710572104191e-43 -0.881957552231161 1.15529457057533e-22 TargetScan -0.164394431071602 1.25931440199374e-17 NA NA NA hsa-miR-361-5p PIK3CA -0.0996867547900457 0.095428250126326 -0.881957552231161 1.15529457057533e-22 mirMAP -0.28523073173792 1.02307804662151e-07 NA NA NA hsa-miR-96-5p PIK3CA 3.24596558166606 1.92296159041707e-98 -0.881957552231161 1.15529457057533e-22 TargetScan -0.158039482109614 1.06514304964241e-18 NA NA NA hsa-miR-30b-3p PIK3CD -0.536462824497982 2.41814659272548e-05 -0.316904328019809 0.0048026997053421 MirTarget -0.12656414985523 3.07110294580941e-05 NA NA NA hsa-miR-484 PIK3CD 0.349444060004737 0.00154491249625173 -0.316904328019809 0.0048026997053421 MirTarget;miRNATAP -0.141552727299567 4.96089022907138e-05 NA NA NA hsa-miR-103a-3p PIK3R1 0.610673390034345 1.63113920514646e-12 -1.70627489565512 1.28475917565256e-44 MirTarget;miRNATAP -0.516011898515825 9.39970675304441e-26 NA NA NA hsa-miR-106b-5p PIK3R1 1.22477789913175 2.31787213143326e-32 -1.70627489565512 1.28475917565256e-44 MirTarget;miRNATAP -0.458684807618424 6.41212047089543e-31 NA NA NA hsa-miR-107 PIK3R1 0.678998026350662 2.56224148930538e-16 -1.70627489565512 1.28475917565256e-44 MirTarget;PITA;miRanda;miRNATAP -0.564782368968385 1.29413413077175e-28 NA NA NA hsa-miR-128-3p PIK3R1 0.90296715955238 9.925204823863e-23 -1.70627489565512 1.28475917565256e-44 MirTarget -0.464882086210543 2.18929508374026e-24 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 1.80754972811286 2.96809840886499e-36 -1.70627489565512 1.28475917565256e-44 MirTarget -0.312737279865189 3.51588268231222e-28 NA NA NA hsa-miR-15a-5p PIK3R1 0.812445324157528 4.50263417099822e-20 -1.70627489565512 1.28475917565256e-44 MirTarget -0.467053807879393 1.27196995879228e-22 NA NA NA hsa-miR-15b-5p PIK3R1 0.788659356634696 1.13678211092534e-11 -1.70627489565512 1.28475917565256e-44 MirTarget -0.304923263873542 1.52536411684308e-16 NA NA NA hsa-miR-16-2-3p PIK3R1 0.286355254959005 0.0256946046884474 -1.70627489565512 1.28475917565256e-44 MirTarget -0.187390623272605 5.18756959426033e-08 NA NA NA hsa-miR-16-5p PIK3R1 0.46835991343556 1.91125356547776e-06 -1.70627489565512 1.28475917565256e-44 MirTarget -0.185144677288316 3.4393027748885e-05 NA NA NA hsa-miR-17-5p PIK3R1 0.599531757298529 1.07318660415906e-05 -1.70627489565512 1.28475917565256e-44 MirTarget;TargetScan;miRNATAP -0.305623214527227 2.73465966965389e-22 NA NA NA hsa-miR-182-5p PIK3R1 2.36408084103818 2.60011457600281e-72 -1.70627489565512 1.28475917565256e-44 miRNATAP -0.209986504782115 4.31661758321545e-12 NA NA NA hsa-miR-185-5p PIK3R1 0.482334746589337 3.68475879959415e-09 -1.70627489565512 1.28475917565256e-44 miRNATAP -0.576307293918371 1.92791131730155e-28 NA NA NA hsa-miR-200b-3p PIK3R1 2.11744072703209 1.66710572104191e-43 -1.70627489565512 1.28475917565256e-44 mirMAP -0.193888157381114 6.36921236487692e-13 NA NA NA hsa-miR-200c-3p PIK3R1 2.07038651806183 6.84613386286599e-51 -1.70627489565512 1.28475917565256e-44 mirMAP -0.257145031020416 2.3912254219973e-18 NA NA NA hsa-miR-20a-5p PIK3R1 0.44979911120222 0.000602386964327228 -1.70627489565512 1.28475917565256e-44 MirTarget;miRNATAP -0.329404805146422 7.47770247059783e-24 NA NA NA hsa-miR-21-5p PIK3R1 2.32007501846389 3.08394781855554e-137 -1.70627489565512 1.28475917565256e-44 miRNAWalker2_validate;MirTarget;miRNATAP -0.442813578327247 2.68375696066295e-30 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-29b-3p PIK3R1 0.438847962603729 6.46722433236121e-05 -1.70627489565512 1.28475917565256e-44 MirTarget;miRNATAP -0.212535407562809 1.00431864575306e-07 NA NA NA hsa-miR-320b PIK3R1 0.412787504747938 0.00113457276903985 -1.70627489565512 1.28475917565256e-44 miRNATAP -0.140552558146201 5.57745902628767e-05 NA NA NA hsa-miR-324-3p PIK3R1 0.404877731996915 0.000340036423920834 -1.70627489565512 1.28475917565256e-44 MirTarget;PITA;miRNATAP -0.224592588456891 6.81384539720142e-09 NA NA NA hsa-miR-330-3p PIK3R1 0.432728362037032 0.00041335506960812 -1.70627489565512 1.28475917565256e-44 MirTarget;PITA;miRNATAP -0.144041669892523 7.57903802651215e-05 NA NA NA hsa-miR-361-5p PIK3R1 -0.0996867547900457 0.095428250126326 -1.70627489565512 1.28475917565256e-44 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.278078422988115 0.000207710985727821 NA NA NA hsa-miR-429 PIK3R1 2.84108892259147 3.88520896426515e-64 -1.70627489565512 1.28475917565256e-44 mirMAP;miRNATAP -0.22503499935046 3.34180951947627e-21 NA NA NA hsa-miR-590-3p PIK3R1 1.27438512890514 1.03164723481469e-23 -1.70627489565512 1.28475917565256e-44 miRanda;mirMAP -0.239713681587516 7.2007499793076e-12 NA NA NA hsa-miR-590-5p PIK3R1 0.746515607868274 8.51300479640125e-09 -1.70627489565512 1.28475917565256e-44 MirTarget;PITA;miRanda;miRNATAP -0.209937562895491 3.68537681569131e-10 NA NA NA hsa-miR-629-3p PIK3R1 1.25035919247365 3.91361135469024e-14 -1.70627489565512 1.28475917565256e-44 MirTarget -0.122961236064884 5.54567297669118e-06 NA NA NA hsa-miR-93-5p PIK3R1 1.01788600209314 1.24312921618126e-21 -1.70627489565512 1.28475917565256e-44 MirTarget;miRNATAP -0.499295395694502 3.97678732290002e-38 NA NA NA hsa-miR-96-5p PIK3R1 3.24596558166606 1.92296159041707e-98 -1.70627489565512 1.28475917565256e-44 TargetScan;miRNATAP -0.245653154038236 3.77424010710224e-23 NA NA NA hsa-miR-126-3p PIK3R2 -1.17432628002954 1.02041618253013e-20 1.28293433832686 8.5972816204378e-73 miRNAWalker2_validate;miRTarBase -0.169496363080053 8.52458360518473e-17 21249429;26384552;27578985;26191164;25240815 Endothelial specific intron derived miR 126 is down regulated in human breast cancer and targets both VEGFA and PIK3R2; VEGFA and PIK3R2 were confirmed as the targets of miR-126 by luciferase reporter assay and Western blot;MicroRNA 126 suppresses proliferation of undifferentiated BRAFV600E and BRAFWT thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K AKT proliferation survival signalling pathway; In addition miR-126 was found to act as proliferation suppressor targeting PIK3R2 gene and reducing p85β a regulatory subunit of PI3K kinase protein translation and lower AKT kinase activity;MiR 126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2 mediated PI3K/Akt signaling pathway; A direct regulatory relationship between miR-126 and the PIK3R2 gene was demonstrated by luciferase reporter assays; Quantitative real-time polymerase chain reaction was used to measure miR-126 and PIK3R2 expressions; Luciferase assays showed that miR-126 significantly inhibited the PIK3R2 3' untranslated region 3'UTR luciferase reporter activity P<0.05; Overexpression of miR-126 negatively regulated the target gene PIK3R2 and further inhibited the PI3K/Akt signaling pathway thereby inhibiting proliferation migration and invasion and promoting apoptosis in BLS cells;Restoration of miR-126 in EC109 cells induced a reduction in PIK3R2 protein levels accompanied with a substantial reduction in phosphorylated AKT levels in EC109 cells suggesting impairment in PI3K/AKT signaling pathway; The luciferase reporter assay confirmed that PIK3R2 was a direct target of miR-126; Taken together our study suggests that miR-126 functions as a potential tumor suppressor in ESCC progression via regulating PI3K/AKT signaling pathway partly by targeting PIK3R2 and targeting of miR-126 may provide a novel strategy for the diagnosis and treatment of ESCC;MiR 126 3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2; LRP6 and PIK3R2 were identified as targets of miR-126-3p; Silencing LRP6 and PIK3R2 had similar effects of miR-126-3p restoration on metastasis and angiogenesis individually in HCC cells; Furthermore the miR-126-3p level was inversely correlated with LRP6 and PIK3R2 in HCC tissues; In addition the rescue experiments indicated that the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2 ;poor survival;;progression;metastasis breast cancer;thyroid cancer;bladder cancer;esophageal cancer;liver cancer hsa-miR-28-5p PIK3R2 -0.14267073663385 0.0497619246260571 1.28293433832686 8.5972816204378e-73 miRanda -0.170225138245223 4.06181677270291e-06 NA NA NA hsa-miR-30b-5p PIK3R2 -0.46540603860146 2.4709940429591e-05 1.28293433832686 8.5972816204378e-73 miRNATAP -0.111541133552651 3.5447180691879e-06 NA NA NA hsa-miR-30c-5p PIK3R2 -0.393222674580066 8.06961465717306e-05 1.28293433832686 8.5972816204378e-73 miRNAWalker2_validate;miRNATAP -0.102854891876324 0.000118472431445014 NA NA NA hsa-miR-30d-5p PIK3R2 -0.247082219011045 0.00406717930063148 1.28293433832686 8.5972816204378e-73 miRNATAP -0.135541098242265 1.30568664423737e-05 NA NA NA hsa-miR-320a PIK3R2 -0.287921276129346 0.00141693637596294 1.28293433832686 8.5972816204378e-73 miRanda -0.151022063052727 3.16338469232646e-07 NA NA NA hsa-miR-491-5p PIK3R2 -1.04307210952796 1.14586501470398e-15 1.28293433832686 8.5972816204378e-73 miRanda -0.116485616092769 7.44579853361516e-09 NA NA NA hsa-miR-181a-5p PIK3R3 0.635863607630183 6.72486918157744e-11 0.559172960265555 3.98014986716526e-09 MirTarget;miRNATAP -0.146056981056209 1.20649375988888e-05 NA NA NA hsa-miR-19b-3p PIK3R3 0.139124391010031 0.255658553872934 0.559172960265555 3.98014986716526e-09 MirTarget;miRNATAP -0.109224067759979 4.71454242795867e-05 NA NA NA hsa-miR-217 PIK3R3 -0.616728851115349 8.64977119332241e-05 0.559172960265555 3.98014986716526e-09 PITA;miRanda -0.118432783728797 1.05730160913028e-08 NA NA NA hsa-miR-25-3p PIK3R3 -0.00546790775985073 0.944061771389468 0.559172960265555 3.98014986716526e-09 MirTarget -0.129911102729152 0.00226643466666436 NA NA NA hsa-miR-26a-5p PIK3R3 -0.481180084102235 1.82368246174758e-10 0.559172960265555 3.98014986716526e-09 miRNATAP -0.28216506702381 5.37056936747542e-11 NA NA NA hsa-miR-374a-5p PIK3R3 -0.239709888246804 0.00309819667153627 0.559172960265555 3.98014986716526e-09 mirMAP -0.121442827230575 0.0029020400924295 NA NA NA hsa-miR-374b-5p PIK3R3 -0.466781429946153 1.17238311619116e-08 0.559172960265555 3.98014986716526e-09 mirMAP -0.120196538768652 0.00271578207935794 NA NA NA hsa-miR-381-3p PIK3R3 -1.28028930293369 1.61402949866141e-23 0.559172960265555 3.98014986716526e-09 mirMAP -0.140767078074606 1.38941193259491e-08 NA NA NA hsa-miR-532-5p PIK3R3 0.0386976222860582 0.682018574136515 0.559172960265555 3.98014986716526e-09 mirMAP -0.140279487612118 5.85354025061255e-05 NA NA NA hsa-miR-92a-3p PIK3R3 -0.342420481092807 0.000732275969501111 0.559172960265555 3.98014986716526e-09 MirTarget;miRNATAP -0.227757876133252 1.19233380886192e-12 NA NA NA hsa-miR-324-5p PLA1A 0.211552647440779 0.139408130311654 0.36089275272922 0.0319978780663896 miRanda -0.121185460778125 0.00267228396767952 NA NA NA hsa-miR-335-5p PLA2G10 -2.61355235628987 2.6462884165886e-51 2.58043646182214 4.92737062096255e-20 miRNAWalker2_validate -0.240771211021386 6.4577488535009e-06 NA NA NA hsa-miR-106b-5p PLA2G12A 1.22477789913175 2.31787213143326e-32 -0.0767339324942657 0.320227624149064 mirMAP -0.183165390972991 4.54130357375406e-14 NA NA NA hsa-miR-140-5p PLA2G12A -0.755971041589807 9.68060922934542e-14 -0.0767339324942657 0.320227624149064 miRanda -0.111542024637763 1.35365987147148e-05 NA NA NA hsa-miR-142-5p PLA2G12A 1.16509303143593 1.96641162209073e-13 -0.0767339324942657 0.320227624149064 mirMAP -0.164913109247326 4.6875674436803e-25 NA NA NA hsa-miR-150-5p PLA2G12A -0.832049526091211 3.45299201139224e-05 -0.0767339324942657 0.320227624149064 mirMAP -0.111662148908207 3.06157352459707e-18 NA NA NA hsa-miR-17-3p PLA2G12A 0.721439431208839 7.95900548819742e-10 -0.0767339324942657 0.320227624149064 mirMAP -0.253144933851736 4.89224736100484e-32 NA NA NA hsa-miR-17-5p PLA2G12A 0.599531757298529 1.07318660415906e-05 -0.0767339324942657 0.320227624149064 mirMAP -0.127012977325803 3.04058434715778e-11 NA NA NA hsa-miR-181a-5p PLA2G12A 0.635863607630183 6.72486918157744e-11 -0.0767339324942657 0.320227624149064 mirMAP -0.134430081680054 5.19065518814422e-07 NA NA NA hsa-miR-181b-5p PLA2G12A 1.22749257795094 1.21998198830919e-27 -0.0767339324942657 0.320227624149064 mirMAP -0.120036146387448 1.07543463907263e-07 NA NA NA hsa-miR-181c-5p PLA2G12A 0.574847839298605 4.51287502066478e-07 -0.0767339324942657 0.320227624149064 mirMAP -0.100247651965663 1.33006792327325e-05 NA NA NA hsa-miR-20a-5p PLA2G12A 0.44979911120222 0.000602386964327228 -0.0767339324942657 0.320227624149064 mirMAP -0.175197436263123 6.04261955331153e-19 NA NA NA hsa-miR-340-5p PLA2G12A 1.0857159627596 4.94471062546756e-24 -0.0767339324942657 0.320227624149064 mirMAP -0.150943983546617 2.10910414124104e-10 NA NA NA hsa-miR-374a-3p PLA2G12A 0.34122393953022 2.28714105382856e-05 -0.0767339324942657 0.320227624149064 mirMAP -0.186349201857001 1.16022667976458e-08 NA NA NA hsa-miR-590-3p PLA2G12A 1.27438512890514 1.03164723481469e-23 -0.0767339324942657 0.320227624149064 PITA;miRanda;miRNATAP -0.102840132884099 1.06330234376856e-06 NA NA NA hsa-miR-93-5p PLA2G12A 1.01788600209314 1.24312921618126e-21 -0.0767339324942657 0.320227624149064 mirMAP -0.16549588295931 4.93444853641411e-12 NA NA NA hsa-miR-142-5p PLA2G16 1.16509303143593 1.96641162209073e-13 -1.28022758594421 3.00579881974141e-18 miRNATAP -0.191719644649097 1.50950332102079e-09 NA NA NA hsa-miR-186-5p PLA2G16 -0.426987301460247 1.04129380549315e-05 -1.28022758594421 3.00579881974141e-18 mirMAP -0.26202373365167 7.19026078970529e-07 NA NA NA hsa-miR-590-3p PLA2G16 1.27438512890514 1.03164723481469e-23 -1.28022758594421 3.00579881974141e-18 miRanda;mirMAP -0.321507336651859 2.39466353360215e-15 NA NA NA hsa-miR-590-5p PLA2G16 0.746515607868274 8.51300479640125e-09 -1.28022758594421 3.00579881974141e-18 miRanda -0.356833977507589 2.06034241696138e-20 NA NA NA hsa-miR-338-3p PLA2G2D 0.0799903526884966 0.575137668326679 0.903280745620558 0.00272639495429831 mirMAP -0.305823183035727 2.42881736158958e-05 NA NA NA hsa-miR-491-5p PLA2G2D -1.04307210952796 1.14586501470398e-15 0.903280745620558 0.00272639495429831 miRanda -0.303164177428281 0.000114708849288704 NA NA NA hsa-let-7d-5p PLA2G3 0.410958462607207 6.07808182756787e-06 -0.0228531479929619 0.949949867171402 MirTarget -0.390954081984527 0.00443149825913952 NA NA NA hsa-miR-98-5p PLA2G3 0.656336869298973 9.03113188590466e-15 -0.0228531479929619 0.949949867171402 MirTarget -0.648796955398098 8.08248391006914e-06 NA NA NA hsa-miR-1301-3p PLA2G4A 1.80754972811286 2.96809840886499e-36 -2.53505849018895 2.47040724186526e-47 MirTarget -0.203345804091857 1.5174493413245e-06 NA NA NA hsa-miR-181b-5p PLA2G4A 1.22749257795094 1.21998198830919e-27 -2.53505849018895 2.47040724186526e-47 MirTarget -0.153639845367177 0.00515313352093704 NA NA NA hsa-miR-181c-5p PLA2G4A 0.574847839298605 4.51287502066478e-07 -2.53505849018895 2.47040724186526e-47 MirTarget -0.154311584569564 0.00569702831812597 NA NA NA hsa-miR-199a-5p PLA2G4D -0.314703593105081 0.00909304983051124 1.65508582123186 6.6817160459539e-13 miRanda -0.338280528463608 3.10845206167542e-07 NA NA NA hsa-miR-125b-5p PLA2G4F -1.94393269763542 2.78180543229264e-58 1.65629880079373 1.17660694478157e-11 miRNAWalker2_validate -0.379967135098276 4.63245426805108e-09 NA NA NA hsa-miR-324-3p PLA2G4F 0.404877731996915 0.000340036423920834 1.65629880079373 1.17660694478157e-11 MirTarget -0.376723268128834 4.47587869831275e-07 NA NA NA hsa-miR-455-5p PLA2G4F 0.284641224662773 0.0357572339594277 1.65629880079373 1.17660694478157e-11 miRanda -0.658686146425405 1.78054062022787e-27 NA NA NA hsa-miR-92a-3p PLA2G4F -0.342420481092807 0.000732275969501111 1.65629880079373 1.17660694478157e-11 miRNAWalker2_validate -1.00983288246488 2.20314222684164e-36 NA NA NA hsa-miR-128-3p PLA2G5 0.90296715955238 9.925204823863e-23 -1.74013770344495 1.68659762319176e-24 miRNAWalker2_validate -0.343165736360574 6.67242916325325e-08 NA NA NA hsa-miR-330-5p PLA2G5 0.626063225953928 3.42215028606779e-09 -1.74013770344495 1.68659762319176e-24 miRanda -0.327612442041135 4.95284334111594e-09 NA NA NA hsa-miR-429 PLA2G5 2.84108892259147 3.88520896426515e-64 -1.74013770344495 1.68659762319176e-24 miRanda -0.333900447814793 4.56777352167666e-25 NA NA NA hsa-miR-590-3p PLA2G5 1.27438512890514 1.03164723481469e-23 -1.74013770344495 1.68659762319176e-24 miRanda;miRNATAP -0.259835376156245 5.88331349780208e-08 NA NA NA hsa-miR-590-5p PLA2G5 0.746515607868274 8.51300479640125e-09 -1.74013770344495 1.68659762319176e-24 miRanda -0.191992596578893 2.94285112416766e-05 NA NA NA hsa-miR-96-5p PLCE1 3.24596558166606 1.92296159041707e-98 -1.32404162040811 1.41903528474939e-14 TargetScan -0.248175684735906 3.58441889575789e-13 NA NA NA hsa-miR-103a-3p PLD1 0.610673390034345 1.63113920514646e-12 -1.5146574391925 4.86890569784769e-35 MirTarget -0.516466208634665 4.51671874608112e-26 NA NA NA hsa-miR-107 PLD1 0.678998026350662 2.56224148930538e-16 -1.5146574391925 4.86890569784769e-35 MirTarget;miRanda -0.351623219124069 1.11110682088749e-11 NA NA NA hsa-miR-15a-5p PLD1 0.812445324157528 4.50263417099822e-20 -1.5146574391925 4.86890569784769e-35 MirTarget -0.326339890526169 1.24001333764783e-11 NA NA NA hsa-miR-182-5p PLD1 2.36408084103818 2.60011457600281e-72 -1.5146574391925 4.86890569784769e-35 MirTarget;miRNATAP -0.397084089244162 8.74101988435737e-43 NA NA NA hsa-miR-183-5p PLD1 2.95681814393872 1.09965777344285e-92 -1.5146574391925 4.86890569784769e-35 mirMAP -0.310405033593345 5.47774252509361e-33 NA NA NA hsa-miR-21-5p PLD1 2.32007501846389 3.08394781855554e-137 -1.5146574391925 4.86890569784769e-35 miRNAWalker2_validate -0.281512820182814 9.16457525889775e-13 NA NA NA hsa-miR-664a-3p PLD1 -0.237699857923843 0.0197071390183375 -1.5146574391925 4.86890569784769e-35 mirMAP -0.128150502452379 0.00301248297257486 NA NA NA hsa-miR-671-5p PLD1 1.55248047544015 7.7377784125886e-33 -1.5146574391925 4.86890569784769e-35 MirTarget -0.17131284581272 1.92286879425328e-07 NA NA NA hsa-miR-96-5p PLD1 3.24596558166606 1.92296159041707e-98 -1.5146574391925 4.86890569784769e-35 miRNATAP -0.328385773592716 1.75638569124427e-42 NA NA NA hsa-miR-107 PLD2 0.678998026350662 2.56224148930538e-16 -0.31625223165727 1.09226107531777e-06 miRanda -0.113936104304697 1.78054999642434e-05 NA NA NA hsa-miR-330-5p PLD2 0.626063225953928 3.42215028606779e-09 -0.31625223165727 1.09226107531777e-06 miRanda -0.13264899987989 1.647564559251e-10 NA NA NA hsa-miR-331-3p PLD2 0.74441480542886 1.17071235477799e-07 -0.31625223165727 1.09226107531777e-06 MirTarget -0.129099096945381 8.48456244676008e-17 NA NA NA hsa-miR-141-3p PRKACB 2.99777540204168 1.26370498493024e-78 -0.383846400368397 0.0117591306589187 MirTarget;TargetScan;miRNATAP -0.14986275424127 3.7367241254854e-07 NA NA NA hsa-miR-17-5p PRKACB 0.599531757298529 1.07318660415906e-05 -0.383846400368397 0.0117591306589187 TargetScan -0.167470485926017 1.11326049159611e-05 NA NA NA hsa-miR-18a-5p PRKACB 0.969066793715868 1.69069796425892e-08 -0.383846400368397 0.0117591306589187 miRNATAP -0.109828861303179 0.000270889162356874 NA NA NA hsa-miR-19a-3p PRKACB 0.817507952171848 3.76285090469625e-08 -0.383846400368397 0.0117591306589187 MirTarget;miRNATAP -0.144307019920445 3.41593280940585e-05 NA NA NA hsa-miR-19b-3p PRKACB 0.139124391010031 0.255658553872934 -0.383846400368397 0.0117591306589187 miRNAWalker2_validate;MirTarget;miRNATAP -0.13474256019019 0.00164169207970928 NA NA NA hsa-miR-200b-3p PRKACB 2.11744072703209 1.66710572104191e-43 -0.383846400368397 0.0117591306589187 MirTarget;TargetScan -0.128358992363134 6.97422500356901e-05 NA NA NA hsa-miR-200c-3p PRKACB 2.07038651806183 6.84613386286599e-51 -0.383846400368397 0.0117591306589187 MirTarget;miRNATAP -0.165596646495394 2.94921644943646e-06 NA NA NA hsa-miR-30d-3p PRKACB 0.264544633563642 0.00755023189129747 -0.383846400368397 0.0117591306589187 mirMAP -0.251818481172515 1.82407867076559e-06 NA NA NA hsa-miR-340-5p PRKACB 1.0857159627596 4.94471062546756e-24 -0.383846400368397 0.0117591306589187 mirMAP -0.151842813986032 0.001373090709035 NA NA NA hsa-miR-361-5p PRKACB -0.0996867547900457 0.095428250126326 -0.383846400368397 0.0117591306589187 miRanda -0.31917046064862 0.000326749716630808 NA NA NA hsa-miR-362-5p PRKACB -0.248676340901797 0.0726089851456282 -0.383846400368397 0.0117591306589187 PITA -0.175108655019306 3.25359783331258e-06 NA NA NA hsa-miR-532-5p PRKACB 0.0386976222860582 0.682018574136515 -0.383846400368397 0.0117591306589187 PITA -0.167904290632964 0.00255889279358267 NA NA NA hsa-miR-93-5p PRKACB 1.01788600209314 1.24312921618126e-21 -0.383846400368397 0.0117591306589187 miRNAWalker2_validate -0.337877597223658 9.95580809015501e-13 NA NA NA hsa-miR-181b-5p PRKCA 1.22749257795094 1.21998198830919e-27 -1.70723657875247 1.7688165305473e-34 mirMAP -0.11742885805708 0.0062191009662321 NA NA NA hsa-miR-181c-5p PRKCA 0.574847839298605 4.51287502066478e-07 -1.70723657875247 1.7688165305473e-34 mirMAP -0.151937361609795 0.00048559417186175 NA NA NA hsa-miR-183-5p PRKCA 2.95681814393872 1.09965777344285e-92 -1.70723657875247 1.7688165305473e-34 miRNATAP -0.382401275003301 4.39521361355191e-39 NA NA NA hsa-miR-193b-3p PRKCA -0.0550374855074773 0.65382485898551 -1.70723657875247 1.7688165305473e-34 miRNAWalker2_validate -0.158591304154604 9.61914010087921e-05 NA NA NA hsa-miR-194-5p PRKCA 0.467781870340114 1.0386810618625e-07 -1.70723657875247 1.7688165305473e-34 mirMAP -0.194734764385864 0.000579018161354159 NA NA NA hsa-miR-200b-3p PRKCA 2.11744072703209 1.66710572104191e-43 -1.70723657875247 1.7688165305473e-34 TargetScan -0.338107140907763 7.43601898887161e-30 NA NA NA hsa-miR-200c-3p PRKCA 2.07038651806183 6.84613386286599e-51 -1.70723657875247 1.7688165305473e-34 miRNATAP -0.384868851727468 4.79014422420278e-32 NA NA NA hsa-miR-29b-2-5p PRKCA -0.263499971180298 0.0400001755611965 -1.70723657875247 1.7688165305473e-34 mirMAP -0.365220324605892 6.60788568306249e-22 NA NA NA hsa-miR-30d-3p PRKCA 0.264544633563642 0.00755023189129747 -1.70723657875247 1.7688165305473e-34 mirMAP -0.185045137833304 0.000246654172160224 NA NA NA hsa-miR-339-5p PRKCA -0.211548290465418 0.0685885445822389 -1.70723657875247 1.7688165305473e-34 mirMAP -0.116903398908303 0.00661066095178211 NA NA NA hsa-miR-340-5p PRKCA 1.0857159627596 4.94471062546756e-24 -1.70723657875247 1.7688165305473e-34 mirMAP -0.157880969288124 0.000482930053726641 NA NA NA hsa-miR-375 PRKCA 2.09893673049766 1.68351780396203e-16 -1.70723657875247 1.7688165305473e-34 miRNAWalker2_validate -0.240131861837491 2.29799527522168e-39 NA NA NA hsa-miR-429 PRKCA 2.84108892259147 3.88520896426515e-64 -1.70723657875247 1.7688165305473e-34 miRanda;miRNATAP -0.302006017947741 7.14515269636082e-30 NA NA NA hsa-miR-141-5p PRKCB 2.38411349683216 4.56310582620282e-58 -0.447147877250759 0.0168049140120418 mirMAP -0.127187131565152 0.00154757873879663 NA NA NA hsa-miR-200b-3p PRKCB 2.11744072703209 1.66710572104191e-43 -0.447147877250759 0.0168049140120418 MirTarget -0.185811618752792 2.61023291805883e-06 NA NA NA hsa-miR-200c-3p PRKCB 2.07038651806183 6.84613386286599e-51 -0.447147877250759 0.0168049140120418 MirTarget;miRNATAP -0.190171510726694 1.24294313881003e-05 NA NA NA hsa-miR-29b-2-5p PRKCB -0.263499971180298 0.0400001755611965 -0.447147877250759 0.0168049140120418 mirMAP -0.248738713275143 5.96583916655133e-07 NA NA NA hsa-miR-30b-5p PRKCB -0.46540603860146 2.4709940429591e-05 -0.447147877250759 0.0168049140120418 mirMAP -0.181899501701348 0.00172429854651836 NA NA NA hsa-miR-30c-5p PRKCB -0.393222674580066 8.06961465717306e-05 -0.447147877250759 0.0168049140120418 mirMAP -0.266676621567604 3.26692465594906e-05 NA NA NA hsa-miR-30d-3p PRKCB 0.264544633563642 0.00755023189129747 -0.447147877250759 0.0168049140120418 mirMAP -0.176195796338334 0.00676988213351706 NA NA NA hsa-miR-338-3p PRKCB 0.0799903526884966 0.575137668326679 -0.447147877250759 0.0168049140120418 miRanda -0.216031823790678 1.44429456470486e-06 NA NA NA hsa-miR-429 PRKCB 2.84108892259147 3.88520896426515e-64 -0.447147877250759 0.0168049140120418 MirTarget;miRanda;miRNATAP -0.177108211107202 5.14864677602474e-07 NA NA NA hsa-miR-664a-3p PRKCB -0.237699857923843 0.0197071390183375 -0.447147877250759 0.0168049140120418 mirMAP -0.30918523276408 8.70938453871888e-07 NA NA NA hsa-miR-107 PTPN11 0.678998026350662 2.56224148930538e-16 -0.73371833861962 7.24333657010257e-22 miRanda -0.163662279556764 2.71436340594115e-07 NA NA NA hsa-miR-181a-5p PTPN11 0.635863607630183 6.72486918157744e-11 -0.73371833861962 7.24333657010257e-22 miRNAWalker2_validate;miRTarBase -0.203894811713478 3.88313891479703e-14 NA NA NA hsa-miR-200b-3p PTPN11 2.11744072703209 1.66710572104191e-43 -0.73371833861962 7.24333657010257e-22 TargetScan -0.131913631045747 6.43155343439281e-16 NA NA NA hsa-miR-200c-3p PTPN11 2.07038651806183 6.84613386286599e-51 -0.73371833861962 7.24333657010257e-22 miRNATAP -0.109200606157251 1.61966841065561e-09 NA NA NA hsa-miR-429 PTPN11 2.84108892259147 3.88520896426515e-64 -0.73371833861962 7.24333657010257e-22 miRNATAP -0.109747504497674 5.95008429105521e-14 NA NA NA hsa-miR-455-5p PTPN11 0.284641224662773 0.0357572339594277 -0.73371833861962 7.24333657010257e-22 miRanda -0.133690861612131 8.9309303633598e-12 NA NA NA hsa-miR-660-5p PTPN11 0.406910761707485 0.000156175371762464 -0.73371833861962 7.24333657010257e-22 mirMAP -0.21890971720391 2.98301188211193e-19 NA NA NA hsa-miR-101-3p RAB5A -0.126035286271986 0.145997832808138 -0.0516753073942766 0.31619228288587 miRNAWalker2_validate;miRTarBase;MirTarget -0.132092729203257 6.66636336351563e-11 24788845 Downregulation of miR 101 3p by hepatitis B virus promotes proliferation and migration of hepatocellular carcinoma cells by targeting Rab5a; Moreover we identified Rab5a was one of the target genes of miR-101-3p in HBV-related HCC; Forced expression of miR-101-3p in liver cell lines resulted in a marked reduction of the expression of Rab5a at both the mRNA and protein level by directly targeting the 3'untranslated region of Rab5a; Overexpression of Rab5a resulted in a reversal of the suppression of proliferation and migration of SMMC-7721 cells mediated by miR-101-3p; Taken together our data show that HBV can downregulate miR-101-3p expression by inhibiting its promoter activity and that downregulation of miR-101-3p promotes HCC cell proliferation and migration by targeting Rab5a liver cancer hsa-miR-106b-5p RAB5B 1.22477789913175 2.31787213143326e-32 -0.039163634111671 0.429993574888726 miRNATAP -0.129855091450922 5.53000153690313e-17 NA NA NA hsa-miR-17-5p RAB5B 0.599531757298529 1.07318660415906e-05 -0.039163634111671 0.429993574888726 miRNAWalker2_validate;TargetScan;miRNATAP -0.118444455805841 9.90144631810287e-23 NA NA NA hsa-miR-20a-5p RAB5B 0.44979911120222 0.000602386964327228 -0.039163634111671 0.429993574888726 miRNATAP -0.161930156946929 1.26845312071384e-39 NA NA NA hsa-miR-24-3p RAB5B -0.120123317289941 0.21432376743243 -0.039163634111671 0.429993574888726 miRNATAP -0.132965039894542 1.71786444289606e-14 NA NA NA hsa-miR-361-3p RAB5B -0.0370446538644886 0.624902392829872 -0.039163634111671 0.429993574888726 miRNATAP -0.187775996341781 2.39661481885559e-17 NA NA NA hsa-miR-93-5p RAB5B 1.01788600209314 1.24312921618126e-21 -0.039163634111671 0.429993574888726 miRNAWalker2_validate;miRNATAP -0.133596549346864 1.75730449469644e-18 NA NA NA hsa-miR-186-5p RAB5C -0.426987301460247 1.04129380549315e-05 0.365005561927163 2.75291403299177e-10 mirMAP -0.187516894932052 1.39746393964512e-20 NA NA NA hsa-miR-101-3p RAC1 -0.126035286271986 0.145997832808138 0.176628662773421 0.000153658997491136 miRNAWalker2_validate;MirTarget -0.139972978942608 1.93650351223228e-14 25202416;24649082;25057058 In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR cell migration;; thyroid cancer;thyroid cancer;colorectal cancer hsa-miR-193b-3p RAC2 -0.0550374855074773 0.65382485898551 0.739175691283857 1.48014827234175e-09 miRNAWalker2_validate -0.163439972898065 2.05534635731132e-06 NA NA NA hsa-miR-491-5p RAC2 -1.04307210952796 1.14586501470398e-15 0.739175691283857 1.48014827234175e-09 miRanda -0.170510866222564 9.84222871672058e-08 NA NA NA hsa-miR-125a-5p RAC3 -0.635694700253268 3.6703235721638e-11 1.34875128530309 1.88353993751843e-24 PITA -0.214154670070607 8.31103753734932e-06 NA NA NA hsa-miR-29a-3p RALA -0.699539666833076 1.13935003139957e-13 0.188109823571631 0.000126889909694842 miRNATAP -0.101048922876897 8.2745887061331e-09 NA NA NA hsa-miR-29c-3p RALA -0.0652732378039769 0.563774115756922 0.188109823571631 0.000126889909694842 miRNATAP -0.150647530978927 2.67444065414951e-25 NA NA NA hsa-let-7g-5p RALB 0.0200025784917734 0.791635298815256 -0.0820708409488073 0.135454523349661 MirTarget;miRNATAP -0.142963009367231 9.1729190547371e-09 NA NA NA hsa-miR-30d-3p RALB 0.264544633563642 0.00755023189129747 -0.0820708409488073 0.135454523349661 MirTarget -0.169988075779142 7.06711325771914e-20 NA NA NA hsa-miR-98-5p RALB 0.656336869298973 9.03113188590466e-15 -0.0820708409488073 0.135454523349661 MirTarget -0.147144341961034 1.25592105585555e-11 NA NA NA hsa-miR-340-5p RALBP1 1.0857159627596 4.94471062546756e-24 -0.13614731053314 0.0258163266517417 mirMAP -0.109951195469105 5.30224158925167e-09 NA NA NA hsa-miR-542-3p RALBP1 0.568822103820889 8.5699075257651e-07 -0.13614731053314 0.0258163266517417 miRanda -0.115610859697906 9.10279695742288e-11 NA NA NA hsa-miR-3913-5p RAP1A 0.71890413546147 2.61153227160465e-13 -0.206644199882094 4.0406371408911e-05 mirMAP -0.121546969384821 1.58087504282888e-12 NA NA NA hsa-miR-107 RAPGEF5 0.678998026350662 2.56224148930538e-16 -0.580652760644656 1.40285189991193e-10 miRanda -0.24550651409548 3.22101815684181e-11 NA NA NA hsa-miR-27b-5p RAPGEF5 0.478244809913032 2.28657237923291e-06 -0.580652760644656 1.40285189991193e-10 mirMAP -0.104560485571521 0.000714959309397951 NA NA NA hsa-miR-320a RAPGEF5 -0.287921276129346 0.00141693637596294 -0.580652760644656 1.40285189991193e-10 miRanda;mirMAP -0.10278577946314 0.0032017550558354 NA NA NA hsa-miR-340-5p RAPGEF5 1.0857159627596 4.94471062546756e-24 -0.580652760644656 1.40285189991193e-10 mirMAP -0.172859361340983 9.09123499498646e-10 NA NA NA hsa-miR-130b-3p RASA1 1.38122163823846 1.00932179737836e-26 -0.294730586920749 0.000766494242183886 MirTarget -0.157001695187525 2.656679234595e-12 NA NA NA hsa-miR-146b-5p RASA1 0.631041661167954 6.20366593452965e-08 -0.294730586920749 0.000766494242183886 miRanda -0.203932611810145 6.33379413307804e-16 NA NA NA hsa-miR-21-5p RASA1 2.32007501846389 3.08394781855554e-137 -0.294730586920749 0.000766494242183886 miRNATAP -0.149767999849588 3.5184635352839e-08 25663768;27101583 RKO cells were transfected with vectors overexpressing or down-regulating either miR-21 or RASA1; Furthermore a luciferase reporter assay was used to determine whether RASA1 is a gene target of miR-21; RASA1 protein levels were significantly decreased in RKO cells compared with the other 5 colon cancer cell lines and RASA1 was confirmed as a target gene of miR-21; Interestingly RASA1 mRNA and protein levels in pre-miR-21-LV up-regulation of miR-21 cells were lower than those in anti-miR-21-LV down-regulation of miR-21 cells P < 0.05; RASA1 is a target gene of miR-21 which promotes malignant behaviors of RKO cells through regulation of RASA1 expression;Circulating MicroRNA 21 Is Involved in Lymph Node Metastasis in Cervical Cancer by Targeting RASA1; Then cervical cancer cell lines HeLa HPV-18 DNA E6/E7RNA and HT-3 HPV DNA E6/E7RNA were used to confirm the interaction between miR-21 and RASA1; MicroRNA-21 reduces RASA1 expression in cervical cancer cell lines and promotes cervical cancer cell migration via RASA1 malignant trasformation;metastasis;cell migration colon cancer;cervical and endocervical cancer hsa-miR-223-3p RASA1 -0.966406159689943 7.90612601654887e-12 -0.294730586920749 0.000766494242183886 MirTarget -0.105611829493872 4.47427896765755e-07 25867276 C/EBP β activated microRNA 223 promotes tumour growth through targeting RASA1 in human colorectal cancer; The levels of RASA1 and miR-223 were analysed by real-time PCR western blotting or in situ immunofluorescence analyses; Upregulation of miR-223 was detected in CRC tissues P<0.01 and was involved in downregulation of RASA1 in CRC tissues; Furthermore the direct inhibition of RASA1 translation by miR-223 and the activation of miR-223 by CCAAT/enhancer binding protein-β C/EBP-β were evaluated in CRC cells; These results identify that C/EBP-β-activated miR-223 contributes to tumour growth by targeting RASA1 in CRC and miR-223-targeted inhibitors may have clinical promise for CRC treatment via suppression of miR-223 colorectal cancer hsa-miR-24-3p RASA1 -0.120123317289941 0.21432376743243 -0.294730586920749 0.000766494242183886 MirTarget;miRNATAP -0.116393363039335 0.000190718929248217 NA NA NA hsa-miR-361-5p RASA1 -0.0996867547900457 0.095428250126326 -0.294730586920749 0.000766494242183886 miRanda -0.25940588477942 3.46447520199015e-07 NA NA NA hsa-miR-590-3p RASA1 1.27438512890514 1.03164723481469e-23 -0.294730586920749 0.000766494242183886 miRanda -0.113657556893731 2.19835293993174e-06 NA NA NA hsa-miR-590-5p RASA1 0.746515607868274 8.51300479640125e-09 -0.294730586920749 0.000766494242183886 miRNATAP -0.127710176275603 2.39199694449279e-08 NA NA NA hsa-miR-92a-3p RASA1 -0.342420481092807 0.000732275969501111 -0.294730586920749 0.000766494242183886 miRNAWalker2_validate -0.197972114017812 1.61082929422124e-11 NA NA NA hsa-miR-141-3p RASA2 2.99777540204168 1.26370498493024e-78 -0.987338236523419 4.85695047036301e-10 TargetScan -0.114558440879572 0.000231326184807738 NA NA NA hsa-miR-200b-3p RASA2 2.11744072703209 1.66710572104191e-43 -0.987338236523419 4.85695047036301e-10 TargetScan -0.116042713824606 0.000635084861671019 NA NA NA hsa-miR-1301-3p RASA3 1.80754972811286 2.96809840886499e-36 -0.949298937256406 7.02819258908652e-24 MirTarget -0.159211435844265 2.87971085681211e-13 NA NA NA hsa-miR-590-3p RASA3 1.27438512890514 1.03164723481469e-23 -0.949298937256406 7.02819258908652e-24 miRanda -0.131080865147668 7.55344454952049e-07 NA NA NA hsa-miR-141-3p RASA4 2.99777540204168 1.26370498493024e-78 -0.759819487285073 1.42668565311618e-13 mirMAP -0.161911829090065 4.4653227116395e-16 NA NA NA hsa-miR-15b-5p RASA4 0.788659356634696 1.13678211092534e-11 -0.759819487285073 1.42668565311618e-13 mirMAP -0.104918915717078 0.00056258591373233 NA NA NA hsa-miR-16-5p RASA4 0.46835991343556 1.91125356547776e-06 -0.759819487285073 1.42668565311618e-13 mirMAP -0.166615352213706 4.07259152916865e-06 NA NA NA hsa-miR-200a-3p RASA4 2.55218480823434 2.96135446816238e-51 -0.759819487285073 1.42668565311618e-13 mirMAP -0.113592876991353 8.69071762139026e-09 NA NA NA hsa-miR-2355-5p RASA4 -0.221733044425126 0.0231054202524677 -0.759819487285073 1.42668565311618e-13 mirMAP -0.124669930417934 0.000688577999624879 NA NA NA hsa-miR-331-3p RASA4 0.74441480542886 1.17071235477799e-07 -0.759819487285073 1.42668565311618e-13 mirMAP -0.235219739964195 1.49517183592453e-21 NA NA NA hsa-miR-590-3p RASA4 1.27438512890514 1.03164723481469e-23 -0.759819487285073 1.42668565311618e-13 miRanda;mirMAP -0.145250016758242 3.47983260618798e-07 NA NA NA hsa-miR-125a-5p RASAL1 -0.635694700253268 3.6703235721638e-11 -0.553411618302433 0.0659491941287804 miRanda -0.425429854694372 6.39102717757399e-05 NA NA NA hsa-miR-342-3p RASAL1 1.21944481975657 6.81914373001202e-19 -0.553411618302433 0.0659491941287804 miRanda -0.560080903129426 1.07678853034341e-14 NA NA NA hsa-miR-107 RASAL2 0.678998026350662 2.56224148930538e-16 -0.566349890853123 1.84617719047055e-11 miRanda -0.18986278214282 4.21803276687423e-08 NA NA NA hsa-miR-128-3p RASAL2 0.90296715955238 9.925204823863e-23 -0.566349890853123 1.84617719047055e-11 MirTarget -0.114813798781172 0.000214896710170242 NA NA NA hsa-miR-200c-3p RASAL2 2.07038651806183 6.84613386286599e-51 -0.566349890853123 1.84617719047055e-11 mirMAP -0.113399606662439 9.2548700645001e-09 NA NA NA hsa-miR-29b-3p RASAL2 0.438847962603729 6.46722433236121e-05 -0.566349890853123 1.84617719047055e-11 MirTarget -0.11335852799536 1.9023443084019e-05 NA NA NA hsa-miR-29c-3p RASAL2 -0.0652732378039769 0.563774115756922 -0.566349890853123 1.84617719047055e-11 MirTarget -0.232369106228742 5.24964244833067e-20 NA NA NA hsa-miR-340-5p RASAL2 1.0857159627596 4.94471062546756e-24 -0.566349890853123 1.84617719047055e-11 mirMAP -0.13980789118701 1.17142910139279e-07 NA NA NA hsa-miR-361-5p RASAL2 -0.0996867547900457 0.095428250126326 -0.566349890853123 1.84617719047055e-11 mirMAP -0.180162620365803 0.000285838479224273 NA NA NA hsa-miR-324-5p RASAL3 0.211552647440779 0.139408130311654 0.693473968116795 2.48403614169211e-07 miRanda -0.179297847094594 2.63938545939942e-08 NA NA NA hsa-miR-615-3p RASAL3 0.659240580933614 0.000360214386152507 0.693473968116795 2.48403614169211e-07 miRNAWalker2_validate -0.103903193004944 3.19968473075021e-05 NA NA NA hsa-miR-125a-5p RASGRF1 -0.635694700253268 3.6703235721638e-11 0.743117588404357 0.000669318514784322 MirTarget;miRanda -0.382319549021974 7.38192594590505e-07 NA NA NA hsa-miR-139-5p RASGRF1 -3.25846663863766 2.62018989415003e-112 0.743117588404357 0.000669318514784322 MirTarget;miRanda -0.135490498006884 0.00264937757767138 NA NA NA hsa-miR-29b-2-5p RASGRF1 -0.263499971180298 0.0400001755611965 0.743117588404357 0.000669318514784322 mirMAP -0.567611118498592 2.55345673613819e-23 NA NA NA hsa-let-7a-3p RASGRF2 0.466622567891891 3.70886257943079e-07 -1.50231288432749 1.31976412389238e-25 mirMAP -0.30132867141085 4.05100292988474e-08 NA NA NA hsa-miR-106a-5p RASGRF2 0.574594373206545 0.000145868284001732 -1.50231288432749 1.31976412389238e-25 MirTarget -0.139221611908457 3.06466373890191e-05 NA NA NA hsa-miR-106b-5p RASGRF2 1.22477789913175 2.31787213143326e-32 -1.50231288432749 1.31976412389238e-25 MirTarget -0.668275349253694 4.76505202716724e-51 NA NA NA hsa-miR-132-3p RASGRF2 -0.0365213889238607 0.668598301088667 -1.50231288432749 1.31976412389238e-25 mirMAP -0.320540348787789 7.60624790957772e-08 NA NA NA hsa-miR-146b-5p RASGRF2 0.631041661167954 6.20366593452965e-08 -1.50231288432749 1.31976412389238e-25 miRanda -0.240514941866759 2.28675484666249e-08 NA NA NA hsa-miR-17-5p RASGRF2 0.599531757298529 1.07318660415906e-05 -1.50231288432749 1.31976412389238e-25 MirTarget;TargetScan -0.421485497153145 4.5074670966001e-32 NA NA NA hsa-miR-182-5p RASGRF2 2.36408084103818 2.60011457600281e-72 -1.50231288432749 1.31976412389238e-25 mirMAP -0.332608173999958 4.42625198160884e-22 NA NA NA hsa-miR-20a-5p RASGRF2 0.44979911120222 0.000602386964327228 -1.50231288432749 1.31976412389238e-25 MirTarget -0.494800335331337 3.12844113623072e-41 NA NA NA hsa-miR-30d-3p RASGRF2 0.264544633563642 0.00755023189129747 -1.50231288432749 1.31976412389238e-25 mirMAP -0.494555232364555 6.19734061181368e-23 NA NA NA hsa-miR-320b RASGRF2 0.412787504747938 0.00113457276903985 -1.50231288432749 1.31976412389238e-25 miRNATAP -0.208686805496719 1.82353808343774e-07 NA NA NA hsa-miR-324-5p RASGRF2 0.211552647440779 0.139408130311654 -1.50231288432749 1.31976412389238e-25 miRNATAP -0.185725603372822 1.44152524752021e-07 NA NA NA hsa-miR-330-3p RASGRF2 0.432728362037032 0.00041335506960812 -1.50231288432749 1.31976412389238e-25 mirMAP -0.213211207472309 3.29302050130744e-07 NA NA NA hsa-miR-429 RASGRF2 2.84108892259147 3.88520896426515e-64 -1.50231288432749 1.31976412389238e-25 miRanda -0.374968653023569 2.6237327482128e-45 NA NA NA hsa-miR-590-3p RASGRF2 1.27438512890514 1.03164723481469e-23 -1.50231288432749 1.31976412389238e-25 MirTarget;miRanda -0.359075593709517 2.04366570773543e-19 NA NA NA hsa-miR-590-5p RASGRF2 0.746515607868274 8.51300479640125e-09 -1.50231288432749 1.31976412389238e-25 miRanda -0.326677798408005 1.14170926955472e-17 NA NA NA hsa-miR-93-5p RASGRF2 1.01788600209314 1.24312921618126e-21 -1.50231288432749 1.31976412389238e-25 MirTarget -0.672023575826152 1.50545432642199e-53 NA NA NA hsa-miR-486-5p RASGRP1 -3.87258704301474 1.22658629378451e-80 0.973407990771331 1.43757924621451e-07 miRanda -0.106236099814952 0.000171212137177818 NA NA NA hsa-miR-758-3p RASGRP1 -0.968261853361846 4.7142782277017e-12 0.973407990771331 1.43757924621451e-07 MirTarget -0.118953001204405 0.00845960520405056 NA NA NA hsa-miR-324-3p RASGRP2 0.404877731996915 0.000340036423920834 -1.0884359274312 5.62935468005693e-10 PITA -0.426569825202945 7.49847398087328e-16 NA NA NA hsa-miR-484 RASGRP2 0.349444060004737 0.00154491249625173 -1.0884359274312 5.62935468005693e-10 PITA -0.437929458450205 6.73502282336069e-16 NA NA NA hsa-miR-30b-3p RASGRP4 -0.536462824497982 2.41814659272548e-05 -0.655281786974586 6.53684341783125e-09 MirTarget -0.179467867827442 4.45509637425569e-09 NA NA NA hsa-miR-107 RASSF5 0.678998026350662 2.56224148930538e-16 0.0430142263181024 0.707562773180603 PITA;miRanda;miRNATAP -0.157104685511007 0.000783755261003707 NA NA NA hsa-miR-125a-5p RASSF5 -0.635694700253268 3.6703235721638e-11 0.0430142263181024 0.707562773180603 miRanda -0.206225935081685 3.21602545553268e-07 NA NA NA hsa-miR-193b-3p RASSF5 -0.0550374855074773 0.65382485898551 0.0430142263181024 0.707562773180603 miRNAWalker2_validate -0.131416859790836 3.9987166167343e-05 NA NA NA hsa-miR-16-1-3p REL 1.30142784811196 2.53343713753744e-29 -0.396598101385942 0.0100846662136365 MirTarget -0.122846289748984 0.00871255502229019 NA NA NA hsa-miR-98-5p REL 0.656336869298973 9.03113188590466e-15 -0.396598101385942 0.0100846662136365 miRNAWalker2_validate -0.217618474263759 0.000427776066595805 NA NA NA hsa-miR-106b-5p RGL1 1.22477789913175 2.31787213143326e-32 -1.67022879602185 1.06541172741944e-55 MirTarget;miRNATAP -0.295904573897857 1.33490732348595e-16 NA NA NA hsa-miR-17-5p RGL1 0.599531757298529 1.07318660415906e-05 -1.67022879602185 1.06541172741944e-55 MirTarget;TargetScan;miRNATAP -0.10683029509006 0.000179495496898804 NA NA NA hsa-miR-182-5p RGL1 2.36408084103818 2.60011457600281e-72 -1.67022879602185 1.06541172741944e-55 MirTarget -0.36525529228356 5.46943760201942e-46 NA NA NA hsa-miR-193a-3p RGL1 0.310617999804917 0.00477640270974957 -1.67022879602185 1.06541172741944e-55 miRNATAP -0.144858602434494 4.37052353454822e-05 NA NA NA hsa-miR-19a-3p RGL1 0.817507952171848 3.76285090469625e-08 -1.67022879602185 1.06541172741944e-55 MirTarget;miRNATAP -0.10173248794915 9.29301055543453e-05 NA NA NA hsa-miR-200b-3p RGL1 2.11744072703209 1.66710572104191e-43 -1.67022879602185 1.06541172741944e-55 MirTarget;TargetScan -0.323125969624857 2.26307711509585e-45 NA NA NA hsa-miR-200c-3p RGL1 2.07038651806183 6.84613386286599e-51 -1.67022879602185 1.06541172741944e-55 MirTarget;miRNATAP -0.366117487037179 1.97365894301561e-48 NA NA NA hsa-miR-20a-5p RGL1 0.44979911120222 0.000602386964327228 -1.67022879602185 1.06541172741944e-55 MirTarget;miRNATAP -0.140721736992658 2.02922869150414e-06 NA NA NA hsa-miR-30d-5p RGL1 -0.247082219011045 0.00406717930063148 -1.67022879602185 1.06541172741944e-55 miRNATAP -0.168658806104524 0.000214676784495689 NA NA NA hsa-miR-32-5p RGL1 1.38676603945192 2.29428299685976e-34 -1.67022879602185 1.06541172741944e-55 MirTarget -0.232052638722537 1.21698957987148e-12 NA NA NA hsa-miR-429 RGL1 2.84108892259147 3.88520896426515e-64 -1.67022879602185 1.06541172741944e-55 MirTarget;PITA;miRanda;miRNATAP -0.283616005237317 1.03067253781092e-43 NA NA NA hsa-miR-625-5p RGL1 0.728939236913178 5.97591217674307e-08 -1.67022879602185 1.06541172741944e-55 MirTarget -0.131439509938379 9.53005906750231e-06 NA NA NA hsa-miR-7-1-3p RGL1 0.686579567507582 1.20731554448806e-07 -1.67022879602185 1.06541172741944e-55 MirTarget;mirMAP -0.140709024783204 2.34044853381958e-06 NA NA NA hsa-miR-92b-3p RGL1 1.30248132773644 9.42428674470985e-25 -1.67022879602185 1.06541172741944e-55 MirTarget -0.189914392594433 1.50276133654173e-10 NA NA NA hsa-miR-93-5p RGL1 1.01788600209314 1.24312921618126e-21 -1.67022879602185 1.06541172741944e-55 MirTarget;miRNATAP -0.321472766147427 4.67767395287619e-20 NA NA NA hsa-miR-96-5p RGL1 3.24596558166606 1.92296159041707e-98 -1.67022879602185 1.06541172741944e-55 mirMAP -0.327210854911904 1.85368593228673e-54 NA NA NA hsa-miR-142-3p RGL2 1.53951237846104 2.06769936282034e-17 0.644125676088622 4.42034436630925e-14 miRanda;miRNATAP -0.127213459087237 7.25766755062034e-16 NA NA NA hsa-miR-196b-5p RGL2 -0.302231359742807 0.0833893928085868 0.644125676088622 4.42034436630925e-14 miRNATAP -0.184555661379644 2.70986188364045e-29 NA NA NA hsa-miR-24-3p RGL2 -0.120123317289941 0.21432376743243 0.644125676088622 4.42034436630925e-14 miRNATAP -0.369012577677113 8.84367621949445e-36 NA NA NA hsa-miR-27a-3p RGL2 0.388496361379095 1.42373532086331e-05 0.644125676088622 4.42034436630925e-14 miRNATAP -0.215610587943759 5.42729799696635e-11 NA NA NA hsa-miR-27b-3p RGL2 -0.0796803270437447 0.410503155574393 0.644125676088622 4.42034436630925e-14 miRNATAP -0.144505964927638 2.52773653802329e-06 NA NA NA hsa-miR-193a-5p RIN1 -1.1508321886378 7.11949564429669e-37 0.390811112878026 0.00117503833555921 miRNATAP -0.135997678679471 0.00188814044217717 NA NA NA hsa-miR-29b-3p RRAS2 0.438847962603729 6.46722433236121e-05 -1.34328469535129 7.92387097337765e-28 miRNATAP -0.1353086916827 0.000630070720017472 NA NA NA hsa-miR-29c-3p RRAS2 -0.0652732378039769 0.563774115756922 -1.34328469535129 7.92387097337765e-28 miRNATAP -0.275043338749693 5.7212064860036e-13 NA NA NA hsa-miR-429 RRAS2 2.84108892259147 3.88520896426515e-64 -1.34328469535129 7.92387097337765e-28 PITA;miRanda -0.157362353521412 3.91853907751419e-11 NA NA NA hsa-miR-186-5p SHC2 -0.426987301460247 1.04129380549315e-05 -0.181909094931012 0.296045257869179 miRNAWalker2_validate -0.756804640103008 6.86430966643839e-38 NA NA NA hsa-miR-21-3p SHC3 2.17476065946878 5.15299442583591e-75 -0.964249961362021 6.05525618490845e-10 MirTarget -0.152288264960436 0.000232456177581898 NA NA NA hsa-miR-182-5p SHC4 2.36408084103818 2.60011457600281e-72 -1.36431335418988 1.20803075809528e-06 MirTarget;miRNATAP -0.455690420006772 7.96697878633079e-12 NA NA NA hsa-miR-664a-3p SHC4 -0.237699857923843 0.0197071390183375 -1.36431335418988 1.20803075809528e-06 mirMAP -0.304875825045051 0.00138983510789235 NA NA NA hsa-miR-96-5p SHC4 3.24596558166606 1.92296159041707e-98 -1.36431335418988 1.20803075809528e-06 TargetScan;miRNATAP -0.301827532688072 5.57748009287207e-08 NA NA NA hsa-miR-103a-3p SHOC2 0.610673390034345 1.63113920514646e-12 -0.109067449058487 0.126039225504713 miRNAWalker2_validate -0.159676371877231 9.29414643132024e-09 NA NA NA hsa-miR-106b-5p SHOC2 1.22477789913175 2.31787213143326e-32 -0.109067449058487 0.126039225504713 MirTarget;miRNATAP -0.191419186372757 9.59452263122113e-18 NA NA NA hsa-miR-128-3p SHOC2 0.90296715955238 9.925204823863e-23 -0.109067449058487 0.126039225504713 MirTarget -0.156047841707624 1.2901578828298e-09 NA NA NA hsa-miR-15a-5p SHOC2 0.812445324157528 4.50263417099822e-20 -0.109067449058487 0.126039225504713 MirTarget;miRNATAP -0.142224700485032 1.24818991558409e-07 NA NA NA hsa-miR-17-5p SHOC2 0.599531757298529 1.07318660415906e-05 -0.109067449058487 0.126039225504713 MirTarget;TargetScan;miRNATAP -0.126894476757768 5.83943164635511e-13 NA NA NA hsa-miR-181a-5p SHOC2 0.635863607630183 6.72486918157744e-11 -0.109067449058487 0.126039225504713 miRNATAP -0.200150408232534 2.58033774140969e-16 NA NA NA hsa-miR-181b-5p SHOC2 1.22749257795094 1.21998198830919e-27 -0.109067449058487 0.126039225504713 miRNATAP -0.177915237190832 5.41069878080871e-18 NA NA NA hsa-miR-20a-5p SHOC2 0.44979911120222 0.000602386964327228 -0.109067449058487 0.126039225504713 MirTarget;miRNATAP -0.204692941205713 3.46224060832768e-30 NA NA NA hsa-miR-361-5p SHOC2 -0.0996867547900457 0.095428250126326 -0.109067449058487 0.126039225504713 PITA;miRanda -0.321923365909381 3.26467533985944e-15 NA NA NA hsa-miR-374a-5p SHOC2 -0.239709888246804 0.00309819667153627 -0.109067449058487 0.126039225504713 MirTarget;mirMAP -0.170435051499224 1.45064810593691e-08 NA NA NA hsa-miR-455-5p SHOC2 0.284641224662773 0.0357572339594277 -0.109067449058487 0.126039225504713 PITA;miRanda;miRNATAP -0.183645800003967 8.47082141620445e-26 NA NA NA hsa-miR-500a-5p SHOC2 0.209805801129289 0.119177819862398 -0.109067449058487 0.126039225504713 MirTarget -0.132422027858316 2.96154071518402e-13 NA NA NA hsa-miR-92a-3p SHOC2 -0.342420481092807 0.000732275969501111 -0.109067449058487 0.126039225504713 miRNAWalker2_validate -0.152339168619365 1.73504495927214e-10 NA NA NA hsa-miR-93-5p SHOC2 1.01788600209314 1.24312921618126e-21 -0.109067449058487 0.126039225504713 MirTarget;miRNATAP -0.188115961559712 1.07659721453431e-17 NA NA NA hsa-miR-107 SOS1 0.678998026350662 2.56224148930538e-16 -0.877855751541721 1.03695500778597e-32 miRNATAP -0.147394654065725 2.31192726053177e-06 NA NA NA hsa-miR-16-1-3p SOS1 1.30142784811196 2.53343713753744e-29 -0.877855751541721 1.03695500778597e-32 mirMAP -0.107043157753765 3.80189774791566e-06 NA NA NA hsa-miR-181a-5p SOS1 0.635863607630183 6.72486918157744e-11 -0.877855751541721 1.03695500778597e-32 MirTarget;miRNATAP -0.159742255037842 1.79079079153389e-09 NA NA NA hsa-miR-181b-5p SOS1 1.22749257795094 1.21998198830919e-27 -0.877855751541721 1.03695500778597e-32 MirTarget;miRNATAP -0.145535984933139 7.83280749467566e-11 NA NA NA hsa-miR-181c-5p SOS1 0.574847839298605 4.51287502066478e-07 -0.877855751541721 1.03695500778597e-32 MirTarget;miRNATAP -0.128681631990538 1.68288122680838e-08 NA NA NA hsa-miR-181d-5p SOS1 0.782618466877349 1.2821116358212e-09 -0.877855751541721 1.03695500778597e-32 MirTarget -0.116569643832434 6.10109884911499e-09 NA NA NA hsa-miR-182-5p SOS1 2.36408084103818 2.60011457600281e-72 -0.877855751541721 1.03695500778597e-32 miRNATAP -0.133258609259375 1.37594627633909e-13 NA NA NA hsa-miR-361-5p SOS1 -0.0996867547900457 0.095428250126326 -0.877855751541721 1.03695500778597e-32 miRanda -0.165292469967548 0.000212244095536951 NA NA NA hsa-miR-429 SOS1 2.84108892259147 3.88520896426515e-64 -0.877855751541721 1.03695500778597e-32 miRanda;miRNATAP -0.114619423820961 9.86568637608249e-16 NA NA NA hsa-miR-542-3p SOS1 0.568822103820889 8.5699075257651e-07 -0.877855751541721 1.03695500778597e-32 miRanda -0.156663695721104 2.52964146595814e-12 NA NA NA hsa-miR-96-5p SOS1 3.24596558166606 1.92296159041707e-98 -0.877855751541721 1.03695500778597e-32 TargetScan;miRNATAP -0.114957974727393 1.33288008849377e-14 NA NA NA hsa-miR-130b-3p SOS2 1.38122163823846 1.00932179737836e-26 -0.693584357428233 2.85648006434693e-23 miRNATAP -0.109371088184118 2.82016388666753e-09 NA NA NA hsa-miR-146b-5p SOS2 0.631041661167954 6.20366593452965e-08 -0.693584357428233 2.85648006434693e-23 miRanda -0.18410115041905 2.89003141851973e-19 NA NA NA hsa-miR-15a-5p SOS2 0.812445324157528 4.50263417099822e-20 -0.693584357428233 2.85648006434693e-23 miRNATAP -0.260459131538532 1.04889039594078e-22 NA NA NA hsa-miR-21-5p SOS2 2.32007501846389 3.08394781855554e-137 -0.693584357428233 2.85648006434693e-23 miRNATAP -0.267389788495656 7.45996997519246e-36 NA NA NA hsa-miR-361-5p STK4 -0.0996867547900457 0.095428250126326 0.174560984522386 0.00453493886022429 mirMAP -0.113189353242031 0.00157853348428608 NA NA NA hsa-miR-146b-3p SYNGAP1 -0.260891807886908 0.0211838235241739 0.0546729843068325 0.492697764557297 PITA;miRNATAP -0.102680439692291 1.98066467799611e-05 NA NA NA hsa-miR-197-3p SYNGAP1 -0.526589453596294 3.61594599437195e-06 0.0546729843068325 0.492697764557297 miRNATAP -0.147355240309131 5.08782719705706e-10 NA NA NA hsa-miR-125a-3p TEK -0.176412960953959 0.10108079286419 -2.06294068128163 1.56421351499436e-50 miRanda -0.160800153949765 0.000632524010983298 NA NA NA hsa-miR-455-5p TEK 0.284641224662773 0.0357572339594277 -2.06294068128163 1.56421351499436e-50 miRanda -0.286824311750872 5.09302613807658e-15 NA NA NA hsa-miR-29b-2-5p TGFA -0.263499971180298 0.0400001755611965 -0.858787895391806 9.79578648139949e-07 mirMAP -0.338031086497945 4.06455756481292e-13 NA NA NA hsa-miR-342-3p TGFA 1.21944481975657 6.81914373001202e-19 -0.858787895391806 9.79578648139949e-07 miRanda -0.21750744009064 3.98827798617966e-07 NA NA NA hsa-miR-338-3p TIAM1 0.0799903526884966 0.575137668326679 0.510860116502581 1.64081645925892e-05 miRanda -0.141290661072522 7.16764176730193e-07 NA NA NA hsa-miR-101-3p VEGFA -0.126035286271986 0.145997832808138 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate -0.244521682678937 1.84891665047835e-09 NA NA NA hsa-miR-134-5p VEGFA -0.943054080774898 1.50079821035544e-12 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.167128564426745 1.10726961805336e-10 NA NA NA hsa-miR-150-5p VEGFA -0.832049526091211 3.45299201139224e-05 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate;miRTarBase -0.151371862718652 1.00198904514709e-18 NA NA NA hsa-miR-195-5p VEGFA -1.47508108420708 2.20685847368258e-38 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.218575701645509 7.55403373439709e-14 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199a-5p VEGFA -0.314703593105081 0.00909304983051124 0.558196398264416 4.82412858140541e-08 miRanda;miRNATAP -0.179279483927549 6.72134651164296e-10 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA -1.37022396448377 3.25758057539223e-26 0.558196398264416 4.82412858140541e-08 miRanda -0.228409524155996 1.33793206666423e-18 NA NA NA hsa-miR-29a-3p VEGFA -0.699539666833076 1.13935003139957e-13 0.558196398264416 4.82412858140541e-08 MirTarget -0.114785243382774 0.00196474782587542 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29c-3p VEGFA -0.0652732378039769 0.563774115756922 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate;MirTarget -0.126355371943564 5.32172855437951e-05 NA NA NA hsa-miR-335-5p VEGFA -2.61355235628987 2.6462884165886e-51 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate -0.103950468396491 4.59347799365143e-08 NA NA NA hsa-miR-497-5p VEGFA -1.4667331575679 5.49909921822638e-36 0.558196398264416 4.82412858140541e-08 MirTarget -0.126722638387264 1.08881401780323e-05 26718330;26485685;26336827;26202364;27015364;25176450;26840372 Furthermore western blot assay confirmed that the overexpression of miR-497 reduced VEGF and HIF-1α protein levels; Moreover miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model which was probably caused by the downregulation of pro-angiogenic molecules such as VEGF and HIF-1α;Role of miR 497 in VEGF A mediated cancer cell growth and invasion in non small cell lung cancer; Here we showed that compared to other cancers NSCLC had a significant higher ratio of VEGF-A protein vs mRNA and significantly lower levels of miR-497 suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers; Compared with paired normal lung tissue NSCLC expressed lower levels of miR-497 and higher levels of VEGF-A; Moreover the levels of miR-497 and VEGF-A were inversely correlated in NSCLC specimen; Bioinformatics analyses showed that miR-497 bound to 3'-UTR of VEGF-A mRNA in NSCLC lines to inhibit its translation; Overexpression of miR-497 in NSCLC lines decreased VEGF-A protein while depletion of miR-497 in NSCLC lines increased VEGF-A protein; However modification of miR-497 levels in NSCLC lines did not alter VEGF-A mRNA levels;MiR 497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG 1; Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions UTRs of vascular endothelial growth factor A VEGFA and astrocyte elevated gene-1 AEG-1;The effects of ectopic miR-497 expression on the expression of VEGFA Akt and p-Akt were determined by western blot; Luciferase reporter assay and western blot confirmed that VEGFA was a direct target of miR-497;Subsequent investigations disclosed that Twist was regulated by miR-497 directly leading to the increased level of Vascular Endothelial Growth Factor-A VEGFA;We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and in turn impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways;Vascular endothelial growth factor-A VEGF-A was confirmed to be a target of miR-497 ;;metastasis;;;; breast cancer;lung squamous cell cancer;liver cancer;sarcoma;pancreatic cancer;ovarian cancer;colorectal cancer hsa-miR-128-3p VEGFC 0.90296715955238 9.925204823863e-23 -0.815181679329146 2.46618490633351e-18 miRNAWalker2_validate;MirTarget -0.277923499247748 3.92415081523196e-16 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-16-2-3p VEGFC 0.286355254959005 0.0256946046884474 -0.815181679329146 2.46618490633351e-18 MirTarget -0.165282903433736 7.39907917672124e-11 NA NA NA hsa-miR-590-3p VEGFC 1.27438512890514 1.03164723481469e-23 -0.815181679329146 2.46618490633351e-18 miRanda -0.194896362906364 4.34747156563496e-14 NA NA NA hsa-miR-326 ZAP70 -1.54449030848141 1.04703417845594e-17 0.308480154953532 0.152665268008893 miRanda -0.175166170665274 1.24040856547915e-05 NA NA NA hsa-miR-338-3p ZAP70 0.0799903526884966 0.575137668326679 0.308480154953532 0.152665268008893 miRanda -0.190767546257396 0.000230745605908227 NA NA NA hsa-miR-339-5p ZAP70 -0.211548290465418 0.0685885445822389 0.308480154953532 0.152665268008893 miRanda -0.283389708874329 8.29021620676906e-06 NA NA NA