miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-27a-3p A1CF -0.370807380415112 0.00875721956202713 -0.979957551696655 1.01468215337271e-05 MirTarget -0.55489980639693 1.63726564624739e-13 NA NA NA hsa-miR-27a-3p ABAT -0.370807380415112 0.00875721956202713 -2.16281544019696 3.93403666966165e-18 MirTarget -0.499810114347108 1.58141958946347e-08 NA NA NA hsa-miR-27a-3p ABCA1 -0.370807380415112 0.00875721956202713 -1.09636606966708 7.96780532063531e-16 miRNAWalker2_validate;MirTarget;miRNATAP -0.151949565429892 0.00176388029000788 NA NA NA hsa-miR-27a-3p ABHD6 -0.370807380415112 0.00875721956202713 -1.31098377221704 2.90575133173284e-15 miRNATAP -0.407096694523204 1.94995919254493e-12 NA NA NA hsa-miR-27a-3p AGGF1 -0.370807380415112 0.00875721956202713 0.137594763085771 0.0302630023319463 miRNATAP -0.115092315879874 8.33599474948448e-08 24462738 Role of microRNA 27a in down regulation of angiogenic factor AGGF1 under hypoxia associated with high grade bladder urothelial carcinoma; Hypoxia-induced down-regulation of AGGF1 was mediated by miR-27a; Overexpression of miR-27a suppressed AGGF1 expression through translational inhibition but not by RNA degradation; Moreover the hypoxia-induced decrease of AGGF1 expression disappeared after miR-27a expression was inhibited bladder cancer hsa-miR-27a-3p AGPAT3 -0.370807380415112 0.00875721956202713 -0.179576731247055 0.0550734832332654 miRNATAP -0.144939193114448 5.71711627006333e-06 NA NA NA hsa-miR-27a-3p AKIRIN2 -0.370807380415112 0.00875721956202713 -0.258502484582304 0.00806807372072467 miRNATAP -0.124413632978095 0.00020556398003452 NA NA NA hsa-miR-27a-3p ALCAM -0.370807380415112 0.00875721956202713 0.241545706158396 0.0536434213260677 MirTarget -0.155644344106583 0.00029434471979165 NA NA NA hsa-miR-27a-3p ALDH9A1 -0.370807380415112 0.00875721956202713 -1.01814226259694 6.41059584460379e-18 miRNAWalker2_validate -0.224001006942239 8.8180251294019e-08 NA NA NA hsa-miR-27a-3p ALG9 -0.370807380415112 0.00875721956202713 0.159698429521322 0.0396311908453304 MirTarget -0.120996814315157 4.73519765806143e-06 NA NA NA hsa-miR-27a-3p APOOL -0.370807380415112 0.00875721956202713 -0.416193043126558 0.0089880844906169 MirTarget -0.10967953497827 0.0468106114003997 NA NA NA hsa-miR-27a-3p AQP11 -0.370807380415112 0.00875721956202713 -0.625509610958238 0.000644636047632557 MirTarget;miRNATAP -0.582396071217295 5.67969485767923e-22 NA NA NA hsa-miR-27a-3p ARHGAP32 -0.370807380415112 0.00875721956202713 -0.199023023372693 0.099211320915758 mirMAP -0.108582048647908 0.00902710044154063 NA NA NA hsa-miR-27a-3p ARID4A -0.370807380415112 0.00875721956202713 -0.895975441173601 4.13512367982488e-14 miRNATAP -0.110325284415838 0.00890783169707931 NA NA NA hsa-miR-27a-3p ARIH2 -0.370807380415112 0.00875721956202713 0.344310627107245 4.29510818034598e-07 miRNATAP -0.113068990282165 1.38730991939636e-06 NA NA NA hsa-miR-27a-3p ARL4D -0.370807380415112 0.00875721956202713 -0.846654741714043 1.8871054459312e-05 miRNATAP -0.453449814020634 1.68807739884772e-11 NA NA NA hsa-miR-27a-3p ARL6IP1 -0.370807380415112 0.00875721956202713 -0.852576906562765 1.79492972834175e-15 miRNAWalker2_validate -0.113300016003383 0.00301780016430237 NA NA NA hsa-miR-27a-3p ARNTL -0.370807380415112 0.00875721956202713 -0.353592991763437 0.0233136973382113 miRNATAP -0.20046978788716 0.0001842305964194 NA NA NA hsa-miR-27a-3p ATP7B -0.370807380415112 0.00875721956202713 -0.73149215480194 1.52550643042418e-05 miRNAWalker2_validate -0.412827377637575 6.06717373375326e-13 NA NA NA hsa-miR-27a-3p BMI1 -0.370807380415112 0.00875721956202713 0.206962604243473 0.0257896566331774 miRNAWalker2_validate -0.176522427069874 2.10168991949445e-08 NA NA NA hsa-miR-27a-3p BRPF3 -0.370807380415112 0.00875721956202713 0.347912163638623 0.00299376429932645 MirTarget;miRNATAP -0.224435422612903 1.89283359423707e-08 NA NA NA hsa-miR-27a-3p BRWD3 -0.370807380415112 0.00875721956202713 0.097389343514537 0.536703137535803 MirTarget;miRNATAP -0.133139725840124 0.0142330872125041 NA NA NA hsa-miR-27a-3p BSN -0.370807380415112 0.00875721956202713 0.943588815475765 2.35563209281755e-05 mirMAP -0.492030842954035 1.01981110038753e-10 NA NA NA hsa-miR-27a-3p C16orf52 -0.370807380415112 0.00875721956202713 -0.498924156279034 2.0232126667381e-06 miRNATAP -0.154995421655171 1.98744118678229e-05 NA NA NA hsa-miR-27a-3p CABLES2 -0.370807380415112 0.00875721956202713 0.815780245768877 1.35421612402299e-10 miRNATAP -0.182533625668255 4.14130945211456e-05 NA NA NA hsa-miR-27a-3p CACNB2 -0.370807380415112 0.00875721956202713 -0.29382108956174 0.151148181646888 MirTarget;miRNATAP -0.167160381183132 0.017987308911521 NA NA NA hsa-miR-27a-3p CADM1 -0.370807380415112 0.00875721956202713 -0.0259171422650883 0.886286112596045 MirTarget;miRNATAP -0.387223004854468 2.49885045365404e-10 NA NA NA hsa-miR-27a-3p CALM3 -0.370807380415112 0.00875721956202713 0.208010932671678 0.0152703300792942 miRNATAP -0.103576968945132 0.000430930143154237 NA NA NA hsa-miR-27a-3p CCDC71 -0.370807380415112 0.00875721956202713 0.0677396402573205 0.373220102596334 MirTarget;miRNATAP -0.101640441159699 8.92335593359721e-05 NA NA NA hsa-miR-27a-3p CCNC -0.370807380415112 0.00875721956202713 -0.298501487898501 0.00149485912023133 MirTarget -0.102895734206518 0.00149777932405706 NA NA NA hsa-miR-27a-3p CCNG1 -0.370807380415112 0.00875721956202713 -0.0461189096804278 0.640330790441284 MirTarget;miRNATAP -0.278947355065841 1.17573051238896e-17 NA NA NA hsa-miR-27a-3p CCNY -0.370807380415112 0.00875721956202713 -0.0249856895879574 0.713069159057291 MirTarget;miRNATAP -0.139625623129884 9.4433057577817e-10 NA NA NA hsa-miR-27a-3p CDC14B -0.370807380415112 0.00875721956202713 -1.18862488716786 6.19212759828214e-11 miRNATAP -0.276640822420895 1.43193730675328e-05 NA NA NA hsa-miR-27a-3p CHKA -0.370807380415112 0.00875721956202713 1.03066945671527 4.50639789726118e-14 miRNATAP -0.239455504717853 6.41778872373064e-07 NA NA NA hsa-miR-27a-3p CLCN5 -0.370807380415112 0.00875721956202713 -0.778462528596492 1.09010470162582e-08 miRNATAP -0.241407255351506 3.21717245855134e-07 NA NA NA hsa-miR-27a-3p CLK2 -0.370807380415112 0.00875721956202713 0.920082317853538 3.42213492570439e-25 miRNATAP -0.100919404740841 0.00183325711091487 NA NA NA hsa-miR-27a-3p CPPED1 -0.370807380415112 0.00875721956202713 0.161877607319542 0.18491305944346 MirTarget -0.321851209772411 2.51778574531631e-15 NA NA NA hsa-miR-27a-3p CTH -0.370807380415112 0.00875721956202713 -2.13323091924521 4.49726796992173e-11 MirTarget;miRNATAP -0.529087008145831 3.15647771113709e-06 NA NA NA hsa-miR-27a-3p CUL1 -0.370807380415112 0.00875721956202713 -0.117901782494851 0.10228448838388 miRNAWalker2_validate -0.100449098638373 4.43211535246804e-05 NA NA NA hsa-miR-27a-3p CYTH1 -0.370807380415112 0.00875721956202713 0.104653949905972 0.17382669123271 miRNATAP -0.219271434813065 5.26954826628707e-18 NA NA NA hsa-miR-27a-3p DCP2 -0.370807380415112 0.00875721956202713 0.261080000757517 0.00123409478740543 miRNATAP -0.111506882324097 5.76694246546213e-05 NA NA NA hsa-miR-27a-3p DCUN1D4 -0.370807380415112 0.00875721956202713 -0.241051443609763 0.00351891274628995 MirTarget;miRNATAP -0.15553713233025 3.00082673091745e-08 NA NA NA hsa-miR-27a-3p DNAJB9 -0.370807380415112 0.00875721956202713 -0.631181264981697 8.66249196538849e-07 miRNATAP -0.188274667609855 2.3119908776759e-05 NA NA NA hsa-miR-27a-3p DVL2 -0.370807380415112 0.00875721956202713 0.932937814675565 4.78146420278758e-20 miRNATAP -0.102448960625914 0.00526923611599277 NA NA NA hsa-miR-27a-3p DYNLL2 -0.370807380415112 0.00875721956202713 -0.626535692486098 7.86372375431067e-08 MirTarget -0.114326358872668 0.0050661336787646 NA NA NA hsa-miR-27a-3p EBF3 -0.370807380415112 0.00875721956202713 1.73730919764558 2.69401589893511e-14 MirTarget;miRNATAP -0.185890416628239 0.022488669590069 NA NA NA hsa-miR-27a-3p EDEM3 -0.370807380415112 0.00875721956202713 0.0146542965491152 0.899151321280748 MirTarget;miRNATAP -0.114529364970318 0.00393826144274326 NA NA NA hsa-miR-27a-3p EI24 -0.370807380415112 0.00875721956202713 -0.751389455631818 2.37502680651615e-14 miRNATAP -0.123305675454532 0.000411566648826186 NA NA NA hsa-miR-27a-3p EIF5 -0.370807380415112 0.00875721956202713 -0.718800486296156 2.12840695796032e-16 MirTarget -0.10950331217895 0.000439308136413365 NA NA NA hsa-miR-27a-3p ELL2 -0.370807380415112 0.00875721956202713 -0.765981836031949 3.63519932659754e-07 MirTarget;miRNATAP -0.36520538428862 1.07287643393358e-12 NA NA NA hsa-miR-27a-3p ELOVL6 -0.370807380415112 0.00875721956202713 -1.01433709478282 1.15410707798086e-06 mirMAP -0.150418284541539 0.0393150371577667 NA NA NA hsa-miR-27a-3p ERP44 -0.370807380415112 0.00875721956202713 -0.186410243164128 0.0125391169517542 mirMAP -0.104508676677441 4.20976866785013e-05 NA NA NA hsa-miR-27a-3p EXOC8 -0.370807380415112 0.00875721956202713 0.110428935685472 0.17333184226714 MirTarget -0.108401370420647 9.08218140970534e-05 NA NA NA hsa-miR-27a-3p FAM120C -0.370807380415112 0.00875721956202713 -0.134586980782029 0.230932149428471 mirMAP;miRNATAP -0.107756857452377 0.00528594090118287 NA NA NA hsa-miR-27a-3p FAM134C -0.370807380415112 0.00875721956202713 0.106109241187649 0.2187282276624 MirTarget -0.166044596248792 1.26492666260296e-08 NA NA NA hsa-miR-27a-3p FAM172A -0.370807380415112 0.00875721956202713 0.227586201706881 0.00597418396634996 MirTarget -0.103839545698547 0.000256763761278271 NA NA NA hsa-miR-27a-3p FAM184A -0.370807380415112 0.00875721956202713 -0.0143574235908157 0.956617794277901 MirTarget -0.616690639723286 3.68450588861667e-12 NA NA NA hsa-miR-27a-3p FAM200B -0.370807380415112 0.00875721956202713 -0.057064574835477 0.511479775862353 MirTarget -0.190779828331638 6.42802278158588e-11 NA NA NA hsa-miR-27a-3p FASN -0.370807380415112 0.00875721956202713 0.950044385482027 2.27190916019197e-06 miRNATAP -0.365233019106792 1.35393114633052e-07 NA NA NA hsa-miR-27a-3p FOXN3 -0.370807380415112 0.00875721956202713 -0.433290741984388 5.6274900890093e-05 miRNATAP -0.246735947197115 1.34692533479721e-11 NA NA NA hsa-miR-27a-3p FOXO1 -0.370807380415112 0.00875721956202713 -1.85047773748744 1.95333497559347e-31 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.124142155509045 0.0360457596456094 25897249;25652374 Adipose tissue secreted miR 27a promotes liver cancer by targeting FOXO1 in obese individuals;The expression of miR-27a and FOXO1 in AsPC-1 cells was determined by real-time RT-PCR and Western blot respectively; Both GSPE and miR-27a inhibitor alone could up-regulate FOXO1 expression ; liver cancer;pancreatic cancer hsa-miR-27a-3p FOXP4 -0.370807380415112 0.00875721956202713 0.403659295563087 6.91439630044943e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.11647604741839 0.000904092415775928 NA NA NA hsa-miR-27a-3p FUBP3 -0.370807380415112 0.00875721956202713 -0.384319652438786 4.56520872825586e-06 miRNATAP -0.106891244955454 0.000228342116756806 NA NA NA hsa-miR-27a-3p GFOD1 -0.370807380415112 0.00875721956202713 -0.739136473829968 1.54144336609472e-06 MirTarget -0.137958931846543 0.0101845467322099 NA NA NA hsa-miR-27a-3p GLYATL1 -0.370807380415112 0.00875721956202713 -3.18323651672202 6.42989464371254e-17 MirTarget -0.543548971920153 6.48750500559823e-05 NA NA NA hsa-miR-27a-3p GPAM -0.370807380415112 0.00875721956202713 -0.472844151955403 0.0637965177079971 miRNAWalker2_validate;MirTarget;miRNATAP -0.668173848034634 4.72678720794009e-15 NA NA NA hsa-miR-27a-3p GPT2 -0.370807380415112 0.00875721956202713 -1.47837181761299 2.51321907474729e-09 miRNAWalker2_validate;mirMAP -0.376774794295884 1.37735573283361e-05 NA NA NA hsa-miR-27a-3p HIPK2 -0.370807380415112 0.00875721956202713 -0.239689841914744 0.0838927941290475 miRNAWalker2_validate;miRNATAP -0.204793071804353 1.60333383106855e-05 20646448;20624637 2 A2780/Taxol cells transfection with inhibitors of miR-27a showed that the levels of MDR1 mRNA was decreased by 39% P-gp protein level 26+/-5% decreased than that in the NC group 43+/-7% HIPK2 protein level 30+/-6% increased than that in the NC group 19+/-4% the 50% inhibition concentration 0.5 micromol/L was less than that in the NC group 6.8 micromol/L apoptosis rate 32.5+/-3.6% was higher than that in the NC group 5.6+/-2.1% and there were significant differences between two groups all P<0.05; The expression of miR-27a is upregulated in A2780/Taxol cells which may regulate MDR1 and P-gp expression by targeting HIPK2;MiR 27a modulates MDR1/P glycoprotein expression by targeting HIPK2 in human ovarian cancer cells; Transfection of A2780/Taxol cells with the inhibitors of miR-27a decreased the expression of MDR1 mRNA and P-gp protein increased HIPK2 protein expression enhanced the sensitivity of A2780/taxol cells to paclitaxel increased paclitaxel-induced apoptosis and the fluorescence intensity of intracellular Rh-123; The deregulation of miR-27a may be involved in the development of drug resistance regulating the expression of MDR1/P-gp at least in part by targeting HIPK2 in ovarian cancer cells ;drug resistance ovarian cancer;ovarian cancer hsa-miR-27a-3p HMGCR -0.370807380415112 0.00875721956202713 -0.0255381303027127 0.860855033325736 miRNATAP -0.373743185114235 1.5085427657671e-14 NA NA NA hsa-miR-27a-3p HORMAD2 -0.370807380415112 0.00875721956202713 -2.20747189021449 9.87041933364421e-08 MirTarget;miRNATAP -0.331669932547712 0.0225190394518121 NA NA NA hsa-miR-27a-3p HSPD1 -0.370807380415112 0.00875721956202713 0.0706956685063815 0.421819194772502 MirTarget -0.143736368638079 1.55574454246056e-06 NA NA NA hsa-miR-27a-3p IMPA1 -0.370807380415112 0.00875721956202713 0.146295288091457 0.151619231073233 miRNAWalker2_validate -0.139831753600137 6.17611762464493e-05 NA NA NA hsa-miR-27a-3p ING5 -0.370807380415112 0.00875721956202713 0.66784229641384 8.47792755654136e-13 MirTarget;miRNATAP -0.186375243713336 1.01858133793578e-08 NA NA NA hsa-miR-27a-3p INSR -0.370807380415112 0.00875721956202713 -0.278293402111066 0.00785689311731476 miRNATAP -0.129448246537712 0.000323191383525876 NA NA NA hsa-miR-27a-3p IPO9 -0.370807380415112 0.00875721956202713 0.702597699750934 1.89164484084094e-17 mirMAP -0.128350642956842 1.24458167165613e-05 NA NA NA hsa-miR-27a-3p IQGAP2 -0.370807380415112 0.00875721956202713 -1.09691498655628 9.21601276995956e-14 MirTarget -0.400223457192296 2.82413505484172e-15 NA NA NA hsa-miR-27a-3p IRS1 -0.370807380415112 0.00875721956202713 -0.221383948238947 0.137544848662312 MirTarget;miRNATAP -0.486219830317146 1.62553310998088e-23 NA NA NA hsa-miR-27a-3p KCTD21 -0.370807380415112 0.00875721956202713 -0.187354284607951 0.061615481087158 miRNATAP -0.193334440402781 1.28197497489688e-08 NA NA NA hsa-miR-27a-3p KHSRP -0.370807380415112 0.00875721956202713 0.308415114038294 1.62771200675314e-05 miRNATAP -0.105956963078366 1.64404111812064e-05 NA NA NA hsa-miR-27a-3p KLF12 -0.370807380415112 0.00875721956202713 -0.863221902725629 5.4142350807271e-09 mirMAP -0.395696355885261 3.68554622881012e-15 NA NA NA hsa-miR-27a-3p KLF3 -0.370807380415112 0.00875721956202713 -0.612085068754795 1.13963384347611e-13 miRNATAP -0.104555587689405 0.000328988529362929 NA NA NA hsa-miR-27a-3p KLHDC3 -0.370807380415112 0.00875721956202713 0.390165827608807 0.000103456605658408 miRNATAP -0.233664455944321 6.42621608264184e-12 NA NA NA hsa-miR-27a-3p KLHL31 -0.370807380415112 0.00875721956202713 1.26597140369387 1.58519014245934e-11 MirTarget -0.200288083272352 0.00254864276818076 NA NA NA hsa-miR-27a-3p LARP4 -0.370807380415112 0.00875721956202713 -0.606974985036527 4.17599364737609e-12 MirTarget;miRNATAP -0.185985589892993 9.05304078571662e-10 NA NA NA hsa-miR-27a-3p LIPT2 -0.370807380415112 0.00875721956202713 -0.0121397937515861 0.921611183822164 MirTarget -0.109726608359752 0.0097217976805758 NA NA NA hsa-miR-27a-3p LPIN1 -0.370807380415112 0.00875721956202713 -0.135731511477539 0.370548383872963 miRNATAP -0.220312099332583 2.15370334956252e-05 NA NA NA hsa-miR-27a-3p LRRC58 -0.370807380415112 0.00875721956202713 -0.0356408411546276 0.759787480699555 mirMAP -0.144487863074203 0.000296819212474494 NA NA NA hsa-miR-27a-3p LSM11 -0.370807380415112 0.00875721956202713 0.758646663868328 2.93737544855881e-13 mirMAP -0.238886717905658 3.52778422976856e-11 NA NA NA hsa-miR-27a-3p LYSMD3 -0.370807380415112 0.00875721956202713 -0.504034718871008 9.84126014307241e-07 miRNAWalker2_validate -0.105163318806014 0.00335638995298051 NA NA NA hsa-miR-27a-3p MAD2L1BP -0.370807380415112 0.00875721956202713 0.165672929463399 0.0411052616844498 MirTarget -0.129250141909554 2.8999785233796e-06 NA NA NA hsa-miR-27a-3p MAGI3 -0.370807380415112 0.00875721956202713 -0.591034618812482 1.94730768066587e-06 MirTarget;miRNATAP -0.165739513255479 0.000120228267853536 NA NA NA hsa-miR-27a-3p MANEAL -0.370807380415112 0.00875721956202713 0.600139712178299 0.000936497225234418 miRNATAP -0.31913081481543 2.82317616675374e-07 NA NA NA hsa-miR-27a-3p MAP3K13 -0.370807380415112 0.00875721956202713 -0.448996281023736 0.0575259551730977 MirTarget -0.182809557840809 0.0252957509604556 NA NA NA hsa-miR-27a-3p MAPK14 -0.370807380415112 0.00875721956202713 -0.144548626010916 0.0495454672602603 MirTarget;miRNATAP -0.141879704151399 1.17885364887775e-08 NA NA NA hsa-miR-27a-3p MBTD1 -0.370807380415112 0.00875721956202713 -0.149823379447637 0.108621879408384 miRNAWalker2_validate -0.178480004760516 1.68435252586667e-08 NA NA NA hsa-miR-27a-3p MED13 -0.370807380415112 0.00875721956202713 -0.257825410256131 0.00586345422218079 MirTarget;miRNATAP -0.172891942723732 5.6441810280982e-08 NA NA NA hsa-miR-27a-3p MEPCE -0.370807380415112 0.00875721956202713 0.255283721593848 0.00176043051414384 miRNATAP -0.156000371529994 1.86070608013261e-08 NA NA NA hsa-miR-27a-3p MIER3 -0.370807380415112 0.00875721956202713 -0.289689451855984 0.00044472169352925 miRNAWalker2_validate;MirTarget;miRNATAP -0.137426339683856 1.10759807535141e-06 NA NA NA hsa-miR-27a-3p MOCS1 -0.370807380415112 0.00875721956202713 -0.555657989620138 3.09140540393222e-05 mirMAP -0.336434468987207 8.03499522837244e-14 NA NA NA hsa-miR-27a-3p MOCS3 -0.370807380415112 0.00875721956202713 0.0560368539268783 0.435291116463034 MirTarget -0.191049597264079 9.14766676368401e-16 NA NA NA hsa-miR-27a-3p MOSPD3 -0.370807380415112 0.00875721956202713 0.255414606041747 0.0194411947908017 miRNATAP -0.181291022034237 1.18419613212569e-06 NA NA NA hsa-miR-27a-3p MREG -0.370807380415112 0.00875721956202713 0.46574853981304 0.000322963837753737 MirTarget -0.170219661474318 0.000140033297258398 NA NA NA hsa-miR-27a-3p MRPS14 -0.370807380415112 0.00875721956202713 0.4264807173503 5.2058598326014e-07 miRNATAP -0.153084336260171 1.63535213820526e-07 NA NA NA hsa-miR-27a-3p MRPS25 -0.370807380415112 0.00875721956202713 0.0188558426537258 0.840264321840341 MirTarget -0.139088528131559 1.28975895911317e-05 NA NA NA hsa-miR-27a-3p MTMR4 -0.370807380415112 0.00875721956202713 -0.200368056480763 0.110719290510537 miRNATAP -0.374524041087563 1.50338546194988e-19 NA NA NA hsa-miR-27a-3p NDUFS4 -0.370807380415112 0.00875721956202713 0.138052953939438 0.21442580930565 MirTarget -0.168179340075643 9.4638428625775e-06 NA NA NA hsa-miR-27a-3p NEDD4 -0.370807380415112 0.00875721956202713 -0.211886112092802 0.209669364741357 MirTarget;miRNATAP -0.382328402883131 1.840207981638e-11 NA NA NA hsa-miR-27a-3p NFIA -0.370807380415112 0.00875721956202713 -0.924685216157224 2.60745966247054e-13 mirMAP;miRNATAP -0.192630710298674 1.55504896532481e-05 NA NA NA hsa-miR-27a-3p NLK -0.370807380415112 0.00875721956202713 0.22134800606754 0.00116385654486987 miRNATAP -0.148898136450612 9.12948651604776e-11 NA NA NA hsa-miR-27a-3p NR1D2 -0.370807380415112 0.00875721956202713 -0.431324257008006 4.19730114867347e-05 miRNATAP -0.140284837212708 0.000114964598489376 NA NA NA hsa-miR-27a-3p NR5A2 -0.370807380415112 0.00875721956202713 -0.702868109735867 0.000206279883850417 miRNATAP -0.160264326745246 0.014882847304086 NA NA NA hsa-miR-27a-3p NRIP1 -0.370807380415112 0.00875721956202713 -0.82531109781187 2.66112725361499e-13 MirTarget;miRNATAP -0.13297498706444 0.000876680163727167 NA NA NA hsa-miR-27a-3p NSA2 -0.370807380415112 0.00875721956202713 0.152301499675499 0.0762962568480935 MirTarget -0.168677437972834 6.48474149319485e-09 NA NA NA hsa-miR-27a-3p NXT2 -0.370807380415112 0.00875721956202713 0.283387452434579 0.0104165744205413 MirTarget;miRNATAP -0.137304803490603 0.00030651999947591 NA NA NA hsa-miR-27a-3p OAF -0.370807380415112 0.00875721956202713 -1.06558162590857 7.23109543686544e-14 MirTarget -0.233550609613841 3.30388050892311e-06 NA NA NA hsa-miR-27a-3p ONECUT2 -0.370807380415112 0.00875721956202713 0.120890541524141 0.551384233388767 miRNATAP -0.487312872313754 8.39956313210927e-13 NA NA NA hsa-miR-27a-3p PAIP2 -0.370807380415112 0.00875721956202713 0.056557716221155 0.394767655062348 MirTarget -0.139624457796024 3.80551510314464e-10 NA NA NA hsa-miR-27a-3p PALM2 -0.370807380415112 0.00875721956202713 -2.07895743328401 4.60304002325711e-20 MirTarget -0.175073245527802 0.0331113299937621 NA NA NA hsa-miR-27a-3p PANK1 -0.370807380415112 0.00875721956202713 -1.78611804711646 1.3683840906107e-26 miRNATAP -0.368459011034843 1.12916280683135e-09 NA NA NA hsa-miR-27a-3p PAQR9 -0.370807380415112 0.00875721956202713 0.136400501110993 0.5121608638586 MirTarget -0.535558103421976 1.31509117955085e-14 NA NA NA hsa-miR-27a-3p PATZ1 -0.370807380415112 0.00875721956202713 0.0890699699572242 0.328770973822428 miRNATAP -0.146960471220815 2.18708383239867e-06 NA NA NA hsa-miR-27a-3p PDE3B -0.370807380415112 0.00875721956202713 -0.985225314310314 3.21148892630576e-08 MirTarget -0.325191791501151 1.3712074138495e-07 NA NA NA hsa-miR-27a-3p PDHX -0.370807380415112 0.00875721956202713 -0.357960061322459 1.41986259575707e-06 MirTarget;miRNATAP -0.158052511602227 4.12155263849178e-10 NA NA NA hsa-miR-27a-3p PDIA5 -0.370807380415112 0.00875721956202713 -0.874347843502598 2.89390019898895e-14 MirTarget;miRNATAP -0.108269209083297 0.0081445353267302 NA NA NA hsa-miR-27a-3p PDK4 -0.370807380415112 0.00875721956202713 -2.10593846974081 2.90436387273985e-14 MirTarget -0.39538195869865 5.70074426478719e-05 NA NA NA hsa-miR-27a-3p PDPK1 -0.370807380415112 0.00875721956202713 0.309856812256619 0.0145897035970451 miRNATAP -0.12746674939881 0.00357863446842311 NA NA NA hsa-miR-27a-3p PEG10 -0.370807380415112 0.00875721956202713 1.32430694329515 0.0306146820128554 MirTarget -0.843570344641501 6.19508070576872e-05 NA NA NA hsa-miR-27a-3p PGAP1 -0.370807380415112 0.00875721956202713 0.012333141833667 0.926382513383674 miRNATAP -0.11363940138435 0.0133927186333443 NA NA NA hsa-miR-27a-3p PHB -0.370807380415112 0.00875721956202713 0.229820504587656 0.0120278226085415 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.12576503732672 6.0612656425522e-05 22505583 Androgen regulated processing of the oncomir miR 27a which targets Prohibitin in prostate cancer; Increasing miR-27a expression results in reduced PHB mRNA and protein levels and increased expression of AR target genes and prostate cancer cell growth prostate cancer hsa-miR-27a-3p PIP4K2B -0.370807380415112 0.00875721956202713 0.57569512577541 7.2526318631119e-15 mirMAP -0.105114314564021 5.74314955627955e-05 NA NA NA hsa-miR-27a-3p PITPNM2 -0.370807380415112 0.00875721956202713 0.252057635121367 0.0799674757736623 miRNATAP -0.172056579183232 0.000507260694204208 NA NA NA hsa-miR-27a-3p PJA2 -0.370807380415112 0.00875721956202713 -0.547154205949659 1.53194178694233e-08 miRNAWalker2_validate -0.110821915116295 0.0010334650693972 NA NA NA hsa-miR-27a-3p PPARA -0.370807380415112 0.00875721956202713 -0.607171871846345 3.30592576448713e-05 MirTarget;miRNATAP -0.40082645940086 3.24328844710871e-16 NA NA NA hsa-miR-27a-3p PPARG -0.370807380415112 0.00875721956202713 0.325170605338307 0.0406603250248875 MirTarget;miRNATAP -0.279326716662458 2.54203678893734e-07 NA NA NA hsa-miR-27a-3p PPP3R1 -0.370807380415112 0.00875721956202713 -0.348267739030591 8.30932335829799e-08 miRNATAP -0.117734120643401 1.31409589262749e-07 NA NA NA hsa-miR-27a-3p PTAR1 -0.370807380415112 0.00875721956202713 -0.30295618795535 0.00286391397269786 MirTarget -0.127302504529677 0.00027083487657158 NA NA NA hsa-miR-27a-3p RAP2C -0.370807380415112 0.00875721956202713 -0.410431451936733 9.12222531349358e-05 miRNATAP -0.156629180592832 1.44783657539562e-05 NA NA NA hsa-miR-27a-3p RGPD5 -0.370807380415112 0.00875721956202713 -0.383976953901903 0.20276110726941 MirTarget -0.268079964025809 0.00995947496720738 NA NA NA hsa-miR-27a-3p RMND5A -0.370807380415112 0.00875721956202713 -0.492348577397466 7.84892428586817e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.269751173020557 9.5128891662544e-16 NA NA NA hsa-miR-27a-3p RORA -0.370807380415112 0.00875721956202713 -1.18591701647076 1.08163415927424e-11 mirMAP;miRNATAP -0.296729273625401 1.22435277100321e-06 NA NA NA hsa-miR-27a-3p RPL19 -0.370807380415112 0.00875721956202713 0.336680236142158 0.00137044723408181 miRNAWalker2_validate -0.101718134374212 0.00513501229795185 NA NA NA hsa-miR-27a-3p RPS18 -0.370807380415112 0.00875721956202713 0.497774311295453 5.48051028550936e-05 miRNAWalker2_validate -0.14896795664491 0.000488528652557028 NA NA NA hsa-miR-27a-3p RPS24 -0.370807380415112 0.00875721956202713 0.267883090577552 0.0468033270606586 miRNAWalker2_validate -0.101189487310556 0.0296690406683812 NA NA NA hsa-miR-27a-3p RPS6KB1 -0.370807380415112 0.00875721956202713 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.13716383977936 2.72226167197111e-08 NA NA NA hsa-miR-27a-3p RPTOR -0.370807380415112 0.00875721956202713 0.681970822272688 1.01116104311691e-17 miRNAWalker2_validate -0.125149802279461 9.56293549288197e-06 NA NA NA hsa-miR-27a-3p RREB1 -0.370807380415112 0.00875721956202713 -0.26573997859693 0.0940609822911551 miRNATAP -0.170016899521806 0.00186223620725445 NA NA NA hsa-miR-27a-3p RYBP -0.370807380415112 0.00875721956202713 -0.687585932862115 8.13175547404103e-17 MirTarget -0.149359163605515 3.02736734951229e-07 NA NA NA hsa-miR-27a-3p SAP30BP -0.370807380415112 0.00875721956202713 0.368688657722243 3.54987836199843e-06 miRNATAP -0.100268082261213 0.000267216670594193 NA NA NA hsa-miR-27a-3p SATB2 -0.370807380415112 0.00875721956202713 0.52003541011141 0.00118691129677399 MirTarget;miRNATAP -0.144109679759717 0.00952108967607689 NA NA NA hsa-miR-27a-3p SBF2 -0.370807380415112 0.00875721956202713 -0.144871095265673 0.248374594908118 MirTarget -0.115301536466929 0.0076077141599621 NA NA NA hsa-miR-27a-3p SDC2 -0.370807380415112 0.00875721956202713 -0.03087902282995 0.814769949243076 miRNATAP -0.385018644333216 8.3041741989374e-19 NA NA NA hsa-miR-27a-3p SEC16A -0.370807380415112 0.00875721956202713 -0.0665051995867652 0.416479000268767 miRNAWalker2_validate -0.110733110979916 7.33590943395806e-05 NA NA NA hsa-miR-27a-3p SEC24A -0.370807380415112 0.00875721956202713 -0.591377269954405 1.3877848945236e-07 MirTarget;miRNATAP -0.1173497936998 0.00275470604604055 NA NA NA hsa-miR-27a-3p SERP1 -0.370807380415112 0.00875721956202713 -0.252864286371366 0.000556618706050377 miRNATAP -0.105249178505928 2.75370100602218e-05 NA NA NA hsa-miR-27a-3p SERPIND1 -0.370807380415112 0.00875721956202713 -1.1296519915006 0.000280652443124669 MirTarget -0.932831827868171 1.83666326535719e-19 NA NA NA hsa-miR-27a-3p SERTAD2 -0.370807380415112 0.00875721956202713 -0.107187476926009 0.246695311043216 mirMAP;miRNATAP -0.143594174021213 5.25349721277052e-06 NA NA NA hsa-miR-27a-3p SETD7 -0.370807380415112 0.00875721956202713 -0.645690628283917 3.04188071973992e-07 miRNAWalker2_validate;mirMAP -0.105859888423504 0.0163459844191305 NA NA NA hsa-miR-27a-3p SGMS1 -0.370807380415112 0.00875721956202713 -0.337617318254549 0.000494506413172613 MirTarget;miRNATAP -0.12157433961383 0.000272550542993425 NA NA NA hsa-miR-27a-3p SH3BGRL2 -0.370807380415112 0.00875721956202713 -0.967834191230422 9.67498247511188e-10 miRNATAP -0.369205103222052 1.18598685819637e-11 NA NA NA hsa-miR-27a-3p SH3GL3 -0.370807380415112 0.00875721956202713 0.563667600337586 0.172947352730134 miRNATAP -0.404053400757807 0.00461766092472469 NA NA NA hsa-miR-27a-3p SLC1A2 -0.370807380415112 0.00875721956202713 -2.05184743338733 5.07102901300161e-06 mirMAP;miRNATAP -1.02868577878672 2.05276140688266e-11 NA NA NA hsa-miR-27a-3p SLC22A23 -0.370807380415112 0.00875721956202713 0.632125395741205 5.61389746801226e-07 MirTarget;miRNATAP -0.149088923427393 0.000700637531140409 NA NA NA hsa-miR-27a-3p SLC25A25 -0.370807380415112 0.00875721956202713 -1.10505911433835 5.5242474077183e-09 miRNATAP -0.285727605121598 1.56380305443755e-05 NA NA NA hsa-miR-27a-3p SLC25A44 -0.370807380415112 0.00875721956202713 0.0123529588568116 0.899846576261205 miRNATAP -0.198867978374769 1.94616457602693e-09 NA NA NA hsa-miR-27a-3p SLC35A3 -0.370807380415112 0.00875721956202713 -0.547853260400994 1.47231547250532e-05 miRNATAP -0.202815446372556 3.29408393839003e-06 NA NA NA hsa-miR-27a-3p SLC38A4 -0.370807380415112 0.00875721956202713 -2.20440604206587 1.47282964888718e-12 miRNATAP -0.58206128659391 9.75538393183348e-08 NA NA NA hsa-miR-27a-3p SLC39A11 -0.370807380415112 0.00875721956202713 -0.270856022501941 0.0195063416023494 miRNATAP -0.122993733365668 0.00207474712634172 NA NA NA hsa-miR-27a-3p SLC6A1 -0.370807380415112 0.00875721956202713 -1.17614916548093 6.73017890737053e-05 MirTarget;miRNATAP -0.712373014693378 1.07196865197655e-12 NA NA NA hsa-miR-27a-3p SLU7 -0.370807380415112 0.00875721956202713 0.242408615769115 0.00022733871534773 MirTarget -0.144490841453336 7.40897059127102e-11 NA NA NA hsa-miR-27a-3p SMARCA1 -0.370807380415112 0.00875721956202713 -0.282636070512839 0.0339024982808055 miRNATAP -0.195581209944447 1.83693894185426e-05 NA NA NA hsa-miR-27a-3p SORL1 -0.370807380415112 0.00875721956202713 -1.76063037333749 3.20297520312196e-18 MirTarget;miRNATAP -0.18552330507774 0.0109103283041572 NA NA NA hsa-miR-27a-3p SOS1 -0.370807380415112 0.00875721956202713 0.05751534180893 0.493041822065916 MirTarget;miRNATAP -0.120226883007702 2.62552416504337e-05 NA NA NA hsa-miR-27a-3p SS18L1 -0.370807380415112 0.00875721956202713 -0.296492401776284 0.0220761965048876 miRNATAP -0.411437486159749 3.42107005680586e-22 NA NA NA hsa-miR-27a-3p STAU1 -0.370807380415112 0.00875721956202713 -0.325342047009626 1.85181071649822e-05 miRNAWalker2_validate -0.172817438997277 1.84467095452792e-11 NA NA NA hsa-miR-27a-3p STBD1 -0.370807380415112 0.00875721956202713 -0.660533943539838 5.58451768316117e-06 MirTarget -0.216094676049773 1.75995222944619e-05 NA NA NA hsa-miR-27a-3p STX1B -0.370807380415112 0.00875721956202713 -0.640719876691996 0.00172836284903972 mirMAP -0.158696611644533 0.0252802536050027 NA NA NA hsa-miR-27a-3p STX5 -0.370807380415112 0.00875721956202713 0.00657125768603084 0.931765686404826 miRNATAP -0.107177734521274 4.12409728888563e-05 NA NA NA hsa-miR-27a-3p SULT4A1 -0.370807380415112 0.00875721956202713 0.999766279782465 0.0548748431251418 miRNATAP -0.354077730693245 0.0494929959029436 NA NA NA hsa-miR-27a-3p SUN2 -0.370807380415112 0.00875721956202713 -0.932850868223685 1.96552976055956e-16 miRNAWalker2_validate -0.100999310348004 0.0128760272980587 NA NA NA hsa-miR-27a-3p SUZ12 -0.370807380415112 0.00875721956202713 0.244635891457675 0.00614848004756525 miRNATAP -0.112312534552759 0.000249347953373446 NA NA NA hsa-miR-27a-3p TAB3 -0.370807380415112 0.00875721956202713 -0.240395619698864 0.0220031162750001 MirTarget -0.174259465024051 1.1466435504835e-06 NA NA NA hsa-miR-27a-3p TAPT1 -0.370807380415112 0.00875721956202713 -1.13334263866931 3.16520734266326e-25 MirTarget;miRNATAP -0.182688449226931 4.08227827624083e-06 NA NA NA hsa-miR-27a-3p TFDP2 -0.370807380415112 0.00875721956202713 -0.0754175393834782 0.416101839729762 mirMAP -0.101203939020943 0.00145452232576687 NA NA NA hsa-miR-27a-3p THOC3 -0.370807380415112 0.00875721956202713 0.399276721087312 1.25813661136998e-05 miRNAWalker2_validate -0.126179999273287 6.4254588136454e-05 NA NA NA hsa-miR-27a-3p THRB -0.370807380415112 0.00875721956202713 -0.630015828817221 1.00813020178641e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.365880905470477 2.80399692304139e-17 NA NA NA hsa-miR-27a-3p TMBIM6 -0.370807380415112 0.00875721956202713 -0.8739716428039 2.36157745837239e-20 MirTarget -0.172441621637881 3.24602948050461e-07 NA NA NA hsa-miR-27a-3p TMCC1 -0.370807380415112 0.00875721956202713 -0.104762238614036 0.46647436251659 miRNATAP -0.156798697049052 0.00151506363463494 NA NA NA hsa-miR-27a-3p TMED5 -0.370807380415112 0.00875721956202713 -0.33764879066855 0.00113254692388959 MirTarget;miRNATAP -0.165475392811241 3.24701444335775e-06 NA NA NA hsa-miR-27a-3p TMEM104 -0.370807380415112 0.00875721956202713 0.843757768707635 5.73449815264737e-17 mirMAP -0.161354647140643 6.60825788456008e-06 NA NA NA hsa-miR-27a-3p TMEM110 -0.370807380415112 0.00875721956202713 -0.263748642092995 0.0243287997140745 MirTarget;miRNATAP -0.211730271683661 1.10721847801967e-07 NA NA NA hsa-miR-27a-3p TMEM170B -0.370807380415112 0.00875721956202713 -0.28665834823882 0.06540862544437 miRNAWalker2_validate;MirTarget;miRNATAP -0.483132497506971 3.42253853404786e-21 NA NA NA hsa-miR-27a-3p TMTC4 -0.370807380415112 0.00875721956202713 -0.0974060527960758 0.375619087504493 MirTarget -0.160146892743012 2.00368064224079e-05 NA NA NA hsa-miR-27a-3p TMUB1 -0.370807380415112 0.00875721956202713 0.0932030228906093 0.37401935982765 MirTarget;miRNATAP -0.137546026046314 0.000126147363750719 NA NA NA hsa-miR-27a-3p TRIM23 -0.370807380415112 0.00875721956202713 -0.298910242960821 0.000941811896082851 MirTarget;miRNATAP -0.118778809442709 0.00013255711570636 NA NA NA hsa-miR-27a-3p TROVE2 -0.370807380415112 0.00875721956202713 0.388164047598623 8.07911996515086e-08 MirTarget;miRNATAP -0.100182605682384 6.40812569611051e-05 NA NA NA hsa-miR-27a-3p TXN2 -0.370807380415112 0.00875721956202713 -0.391629560113942 1.98770491969482e-05 MirTarget -0.109702177764506 0.000552423871241038 NA NA NA hsa-miR-27a-3p UBE2Q1 -0.370807380415112 0.00875721956202713 0.732919157465649 1.09455000536515e-20 miRNATAP -0.125386671239813 8.35819334292529e-06 NA NA NA hsa-miR-27a-3p UBE4A -0.370807380415112 0.00875721956202713 -0.18436367635478 0.00481429470133437 miRNATAP -0.110330022431295 6.87161292798301e-07 NA NA NA hsa-miR-27a-3p USP13 -0.370807380415112 0.00875721956202713 -0.113218820052341 0.256649434546091 mirMAP -0.115173643397693 0.000763798703245775 NA NA NA hsa-miR-27a-3p VAV2 -0.370807380415112 0.00875721956202713 -0.212497701618211 0.020906678260825 miRNATAP -0.161080745637534 2.6951135022762e-07 NA NA NA hsa-miR-27a-3p VKORC1L1 -0.370807380415112 0.00875721956202713 -0.437057501700886 5.88971250408357e-09 mirMAP -0.116314402929017 7.98354267232132e-06 NA NA NA hsa-miR-27a-3p VPS26B -0.370807380415112 0.00875721956202713 -0.15373251883815 0.0460180713795288 MirTarget -0.123980469828719 2.26124678851181e-06 NA NA NA hsa-miR-27a-3p WNK3 -0.370807380415112 0.00875721956202713 -0.836532944570787 0.00785592148273515 miRNATAP -0.605889434207314 1.64481792961939e-08 NA NA NA hsa-miR-27a-3p XPO1 -0.370807380415112 0.00875721956202713 0.457663973329897 3.78607050139453e-13 miRNATAP -0.109834218348528 5.80324265374656e-07 NA NA NA hsa-miR-27a-3p ZBTB10 -0.370807380415112 0.00875721956202713 -1.01864761075705 2.61637300384558e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.132605301788693 0.0101670894204717 23240057;23752185;19639204;20666778;20488920;20382698;23530649;18006846;23471840;19582879 MicroRNA-27a miR-27a is thought to be an onco-microRNA that promotes tumor growth and metastasis by downregulating ZBTB10; The expression of miR-27a and ZBTB10 was examined in 102 breast cancer cases using in situ hybridization ISH and immunohistochemistry techniques and were evaluated semi-quantitatively by examining the staining index; The Correlation of miR-27a and ZBTB10 expression was analyed by Spearman Rank Correlation; The association of miR-27a and ZBTB10 expression with clinicopathological characteristics was analyzed using the χ2 test and their effects on patient survival were analyzed by a log-rank test and the Kaplan-Meier method; Univariate and multivariate Cox regression analyses were used to evaluate the prognostic values of miR-27a and ZBTB10 miR-27a was markedly up-regulated in invasive breast cancers that expressed low levels of ZBTB10 P<0.001; A reverse correlation between miR-27a and ZBTB10 was also observed in breast cancer tissue samples rs = -0.478 P<0.001; Furthermore the expression of miR-27a and ZBTB10 was significantly correlated with clinicopathological parameters including tumor size lymph node metastasis and distant metastasis P<0.05 but not with receptor status; Patients with high miR-27a or low ZBTB10 expression tended to have significantly shorter disease-free survival times 57 months and 53 months respectively P <0.001 and overall survival times 58 months and 55 months respectively P <0.001; Univariate and multivariate analysis showed that both miR-27a and ZBTB10 were independent prognostic factors of disease-free survival in breast cancer patients P <0.001 while only miR-27a was an independent predictor of overall survival P <0.001;Increased miR-27a paralleled the reduced expression of ZBTB10 a known miR-27a target; Both expression of miR-27a and knockdown of ZBTB10 in BCSLCs promoted in vivo angiogenesis and tumor metastasis;In the present study we explored the possible activity of genistein to inhibit human uveal melanoma cell growth and investigated the possible role of genistein on microRNA-27a miR-27a as well as its target gene zinc finger and BTB domain containing 10 ZBTB10 expression levels; Further functional assays revealed that the levels of miR-27a and its target gene ZBTB10 were significantly different based on the dose of genistein;Here we investigated the possible role of a common A/G polymorphism rs895819 within hsa-mir-27a in the development or progression of gastric cancer and assessed the effect of rs895819 on the expression of miR-27a and its target gene Zinc finger and BTB domain containing 10 ZBTB10; Further functional analyses indicated that variant genotypes might be responsible for elevated miR-27a levels and reduced ZBTB10 mRNA; Moreover an inverse correlation was found between ZBTB10 and miR-27a levels; In conclusion we were the first to show that a common polymorphism rs895819 in hsa-mir-27a by modulating miR-27a and ZBTB10 levels acted as an important factor of the gastric cancer susceptibility;Repression of Sp and Sp-dependent genes by CDDO-Me was due to the down-regulation of microRNA-27a and induction of zinc finger and BTB domain containing 10 ZBTB10 an Sp repressor and these responses were also reversed by antioxidants;Thus miR-27a indirectly regulates E2-responsiveness in MCF-7 cells through suppression of ZBTB10 thereby enhancing expression of ERalpha;RQ decreased microRNA-27a miR-27a and induced zinc finger protein ZBTB10 an Sp-repressor suggesting that interactions of RQ with the miR-27a-ZBTB10-axis play a role in Sp downregulation;Thus the oncogenic activity of miR-27a in MDA-MB-231 cells is due in part to suppression of ZBTB10 and Myt-1;The drug resistance suppression induced by curcuminoids in colon cancer SW 480 cells is mediated by reactive oxygen species induced disruption of the microRNA 27a ZBTB10 Sp axis;CDODA-Me decreased expression of microRNA-27a miR-27a and this was accompanied by increased expression of 2 miR-27a-regulated mRNAs namely ZBTB10 an Sp repressor and Myt-1 which catalyzes phosphorylation of cdc2 to inhibit progression of cells through G2/M metastasis;poor survival;tumor size;metastasis;;progression;drug resistance;;;;drug resistance;progression breast cancer;breast cancer;melanoma;gastric cancer;pancreatic cancer;breast cancer;colon cancer;breast cancer;colon cancer;colon cancer hsa-miR-27a-3p ZBTB39 -0.370807380415112 0.00875721956202713 0.298869678409894 0.00533252508909905 miRNATAP -0.140048474887636 0.000145683631613572 NA NA NA hsa-miR-27a-3p ZCCHC24 -0.370807380415112 0.00875721956202713 -1.09299525922251 5.15915193886857e-19 MirTarget;miRNATAP -0.120601283237384 0.00637110850921819 NA NA NA hsa-miR-27a-3p ZFHX4 -0.370807380415112 0.00875721956202713 -0.832628706674559 7.07667307978028e-05 MirTarget;miRNATAP -0.28816598274581 7.01903445442891e-05 NA NA NA hsa-miR-27a-3p ZHX1 -0.370807380415112 0.00875721956202713 0.0858574571573554 0.469889631735741 miRNATAP -0.132830471147249 0.00112457659988099 NA NA NA hsa-miR-27a-3p ZNF268 -0.370807380415112 0.00875721956202713 -0.593152337415467 2.02863291106211e-05 MirTarget -0.15663403604109 0.00118731994092005 NA NA NA hsa-miR-27a-3p ZNF329 -0.370807380415112 0.00875721956202713 -0.0699667141892797 0.617731536955896 miRNATAP -0.155044147222143 0.00128320353647225 NA NA NA hsa-miR-27a-3p ZNF516 -0.370807380415112 0.00875721956202713 0.124746651364675 0.25878672399708 miRNATAP -0.100302260185465 0.00830201640426921 NA NA NA hsa-miR-27a-3p ZNF620 -0.370807380415112 0.00875721956202713 0.316668738238858 0.00569031792394154 miRNATAP -0.1402660225998 0.000373324670042687 NA NA NA