miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-2-3p ADAMTS5 -0.295235553592456 0.00290654476250626 0.247127577081209 0.0171012547059892 mirMAP -0.26756700551301 3.59333278465033e-09 NA NA NA hsa-let-7a-3p ADAMTS5 -0.0530563276543585 0.370749834463726 0.247127577081209 0.0171012547059892 mirMAP -0.278183263638905 0.0010353302966896 NA NA NA hsa-let-7b-3p ADAMTS5 0.00495618733300152 0.95228898068683 0.247127577081209 0.0171012547059892 mirMAP -0.134125758162629 0.0180131910189072 NA NA NA hsa-let-7d-5p ADAMTS5 -0.111345229817881 0.0872634398337596 0.247127577081209 0.0171012547059892 miRNATAP -0.561003043114061 2.64648196582556e-11 NA NA NA hsa-let-7e-5p ADAMTS5 -0.0471189209570024 0.657255455444874 0.247127577081209 0.0171012547059892 miRNATAP -0.369019700511555 3.40732248914429e-14 NA NA NA hsa-let-7f-1-3p ADAMTS5 -0.110713086694052 0.214845243005185 0.247127577081209 0.0171012547059892 mirMAP -0.354586354726111 5.81411218068828e-13 NA NA NA hsa-let-7f-5p ADAMTS5 -0.0508269185845212 0.626775150458244 0.247127577081209 0.0171012547059892 miRNATAP -0.256206366625198 5.64405358906823e-06 NA NA NA hsa-let-7g-3p ADAMTS5 -0.00917503654782248 0.927869753389243 0.247127577081209 0.0171012547059892 mirMAP -0.168767758394937 0.000224089254111957 NA NA NA hsa-let-7g-5p ADAMTS5 0.025339633460872 0.742556489443337 0.247127577081209 0.0171012547059892 miRNATAP -0.476470171660422 2.24436353682541e-10 NA NA NA hsa-let-7i-5p ADAMTS5 -0.0952853587923013 0.192120688957357 0.247127577081209 0.0171012547059892 miRNATAP -0.271985810266608 0.00050454013165471 NA NA NA hsa-miR-106b-5p ADAMTS5 -0.167096183547595 0.0497544396383733 0.247127577081209 0.0171012547059892 miRNATAP -0.260356361234397 1.19899827756306e-05 NA NA NA hsa-miR-125b-2-3p ADAMTS5 0.0775572585326296 0.381771874711932 0.247127577081209 0.0171012547059892 mirMAP -0.206310582219656 0.000181566269358246 NA NA NA hsa-miR-126-5p ADAMTS5 -0.177332403948646 0.0711675116243408 0.247127577081209 0.0171012547059892 mirMAP -0.198413250983765 3.1485701135533e-05 NA NA NA hsa-miR-132-3p ADAMTS5 0.178379362833879 0.133352008771241 0.247127577081209 0.0171012547059892 miRNATAP -0.208030985229923 1.53750639081733e-07 NA NA NA hsa-miR-140-5p ADAMTS5 -0.0650635071034511 0.380452509211897 0.247127577081209 0.0171012547059892 PITA;miRanda;miRNATAP -0.31471695217999 1.43781320676439e-06 NA NA NA hsa-miR-142-3p ADAMTS5 -0.558908907203953 1.37828834702525e-05 0.247127577081209 0.0171012547059892 PITA;miRanda -0.213664720017465 1.59685681674808e-09 NA NA NA hsa-miR-142-5p ADAMTS5 -0.434884875454099 0.000575570345702933 0.247127577081209 0.0171012547059892 PITA;mirMAP;miRNATAP -0.240437068769732 3.89634216075425e-12 NA NA NA hsa-miR-145-5p ADAMTS5 -0.108948399942988 0.310032352776812 0.247127577081209 0.0171012547059892 miRNATAP -0.199430346040158 5.90162869560991e-06 NA NA NA hsa-miR-148a-3p ADAMTS5 -0.30682159249341 0.039235695888613 0.247127577081209 0.0171012547059892 miRNATAP -0.131840626927494 3.10827457459695e-05 NA NA NA hsa-miR-154-5p ADAMTS5 0.226468848904459 0.107380908211265 0.247127577081209 0.0171012547059892 mirMAP -0.150754561609873 2.01525437493071e-06 NA NA NA hsa-miR-15a-5p ADAMTS5 -0.142658985373589 0.0536219185009377 0.247127577081209 0.0171012547059892 miRNATAP -0.435415123526458 1.95303885370203e-09 NA NA NA hsa-miR-15b-3p ADAMTS5 -0.690804403863834 8.4878475512421e-09 0.247127577081209 0.0171012547059892 mirMAP -0.211824779019689 5.35241176480036e-09 NA NA NA hsa-miR-15b-5p ADAMTS5 -0.59286315669281 1.41971517354318e-10 0.247127577081209 0.0171012547059892 miRNATAP -0.315425868602669 3.44176698836866e-10 NA NA NA hsa-miR-16-5p ADAMTS5 -0.246024668671255 0.00346042804504067 0.247127577081209 0.0171012547059892 miRNATAP -0.320654282106413 2.90178929428321e-07 NA NA NA hsa-miR-181a-5p ADAMTS5 0.178215604431884 0.0700010802254993 0.247127577081209 0.0171012547059892 mirMAP;miRNATAP -0.167250544213817 0.00756034771712508 NA NA NA hsa-miR-181b-5p ADAMTS5 -0.0260899284211344 0.768941836912778 0.247127577081209 0.0171012547059892 mirMAP;miRNATAP -0.207995352292774 0.00099505662833023 NA NA NA hsa-miR-194-5p ADAMTS5 0.122590607867661 0.10375508705371 0.247127577081209 0.0171012547059892 mirMAP -0.153135292179762 0.0237072734257945 NA NA NA hsa-miR-200b-3p ADAMTS5 -0.24576852650451 0.0580744465744749 0.247127577081209 0.0171012547059892 mirMAP -0.292020246899473 1.39215164905824e-17 NA NA NA hsa-miR-212-3p ADAMTS5 0.0141129412093419 0.918360379513015 0.247127577081209 0.0171012547059892 miRNATAP -0.191106443985196 2.86465275517048e-09 NA NA NA hsa-miR-299-5p ADAMTS5 0.0814737109317376 0.576202442267832 0.247127577081209 0.0171012547059892 miRNATAP -0.153473105601 6.9693363701021e-07 NA NA NA hsa-miR-29a-5p ADAMTS5 0.0697727833812762 0.350621682973061 0.247127577081209 0.0171012547059892 mirMAP -0.36007239142016 2.8065131051892e-09 NA NA NA hsa-miR-30a-3p ADAMTS5 -0.0655410309550497 0.509541256242263 0.247127577081209 0.0171012547059892 miRNATAP -0.232818258426599 7.35576508967921e-05 NA NA NA hsa-miR-30d-3p ADAMTS5 -0.0854049347792865 0.206912548011228 0.247127577081209 0.0171012547059892 miRNATAP -0.403619860973927 1.01298750827993e-09 NA NA NA hsa-miR-330-3p ADAMTS5 0.427388106938161 0.003004892844142 0.247127577081209 0.0171012547059892 miRNATAP -0.176275277836879 8.40532502400138e-09 NA NA NA hsa-miR-337-3p ADAMTS5 -0.117985828329964 0.34639201895679 0.247127577081209 0.0171012547059892 mirMAP -0.15433077368319 1.56759102672199e-05 NA NA NA hsa-miR-33a-3p ADAMTS5 0.15836637661919 0.0991512910387245 0.247127577081209 0.0171012547059892 mirMAP -0.165636109591726 0.000412009895653854 NA NA NA hsa-miR-33a-5p ADAMTS5 -0.0197996465877068 0.868306560389703 0.247127577081209 0.0171012547059892 mirMAP -0.163088641091779 1.40250645937897e-05 NA NA NA hsa-miR-361-5p ADAMTS5 -0.0107519600643009 0.882230614095884 0.247127577081209 0.0171012547059892 PITA;miRanda -0.67046767539992 1.80515165918185e-19 NA NA NA hsa-miR-374a-3p ADAMTS5 -0.176226170437582 0.0343958848425882 0.247127577081209 0.0171012547059892 mirMAP -0.493345728501478 6.45336329016065e-14 NA NA NA hsa-miR-374a-5p ADAMTS5 -0.0121037060909126 0.865417963346047 0.247127577081209 0.0171012547059892 mirMAP -0.36944742695389 3.80627246047215e-08 NA NA NA hsa-miR-374b-5p ADAMTS5 0.210113949579637 0.00568660838185483 0.247127577081209 0.0171012547059892 mirMAP -0.299425510697285 7.0883946399594e-06 NA NA NA hsa-miR-381-3p ADAMTS5 0.192118086401452 0.203198554750038 0.247127577081209 0.0171012547059892 mirMAP -0.13222551303113 9.2634076256838e-06 NA NA NA hsa-miR-409-3p ADAMTS5 -0.00456692516633206 0.974143243758572 0.247127577081209 0.0171012547059892 mirMAP -0.124667582029366 8.69081034619184e-05 NA NA NA hsa-miR-411-3p ADAMTS5 0.239070412422695 0.0940658517658319 0.247127577081209 0.0171012547059892 mirMAP -0.141033848398357 9.0092529499346e-06 NA NA NA hsa-miR-421 ADAMTS5 0.171573235029884 0.0518112933650958 0.247127577081209 0.0171012547059892 mirMAP -0.352215542532251 2.10926158467776e-12 NA NA NA hsa-miR-452-5p ADAMTS5 -0.599327068454216 1.02031931068513e-05 0.247127577081209 0.0171012547059892 mirMAP;miRNATAP -0.127649698401949 9.06368225030463e-05 NA NA NA hsa-miR-495-3p ADAMTS5 0.421982588962492 0.00504424038527033 0.247127577081209 0.0171012547059892 mirMAP -0.143601196487223 1.27690393479471e-06 NA NA NA hsa-miR-496 ADAMTS5 0.139833482232875 0.395975418625328 0.247127577081209 0.0171012547059892 mirMAP -0.106292858019068 0.000111670500210313 NA NA NA hsa-miR-497-5p ADAMTS5 0.000783764887907878 0.991703566618646 0.247127577081209 0.0171012547059892 miRNATAP -0.176898980263836 0.00578015754017585 NA NA NA hsa-miR-539-5p ADAMTS5 0.326485413953599 0.0554453076411236 0.247127577081209 0.0171012547059892 mirMAP -0.113542183340116 1.33964559235686e-05 NA NA NA hsa-miR-543 ADAMTS5 0.347737549779626 0.0157394585079679 0.247127577081209 0.0171012547059892 mirMAP -0.130776519292562 3.68619403150224e-05 NA NA NA hsa-miR-590-3p ADAMTS5 -0.312951515438399 0.00048045542384394 0.247127577081209 0.0171012547059892 PITA;miRanda;miRNATAP -0.348978007112775 1.11756547147994e-12 NA NA NA hsa-miR-590-5p ADAMTS5 -0.169460270359482 0.0386004382081766 0.247127577081209 0.0171012547059892 miRanda -0.436032091741021 6.60490038540391e-16 NA NA NA hsa-miR-664a-3p ADAMTS5 -0.0413918462466984 0.611334357897205 0.247127577081209 0.0171012547059892 mirMAP -0.432422434504664 5.17193214361944e-15 NA NA NA hsa-miR-7-1-3p ADAMTS5 0.0894475316162513 0.373223597851017 0.247127577081209 0.0171012547059892 mirMAP -0.241652912471872 5.9982655622971e-08 NA NA NA hsa-miR-98-5p ADAMTS5 0.0806971683871804 0.251777941211574 0.247127577081209 0.0171012547059892 miRNAWalker2_validate -0.51842960921151 2.60536675465219e-13 NA NA NA hsa-miR-106b-5p ADRA2A -0.167096183547595 0.0497544396383733 0.267826692317843 0.0475910435044753 miRNATAP -0.166448175567055 0.0352682916198781 NA NA NA hsa-miR-130a-5p ADRA2A -0.155569168973665 0.088424626138481 0.267826692317843 0.0475910435044753 miRNATAP -0.133841816101122 0.0427686048050413 NA NA NA hsa-miR-20a-5p ADRA2A 0.0115865752289119 0.887069448775761 0.267826692317843 0.0475910435044753 miRNATAP -0.393177283891007 6.03831167916916e-06 NA NA NA hsa-miR-124-3p AK2 0.506026514549267 0.00780563703586767 -0.282715213855517 9.17117363489464e-06 miRNAWalker2_validate;miRNATAP -0.112924267902865 2.59898856376171e-20 NA NA NA hsa-miR-129-5p AK2 0.567133990117154 0.00116152215679873 -0.282715213855517 9.17117363489464e-06 miRanda -0.101951659234979 1.17363546190466e-13 NA NA NA hsa-miR-361-5p ANKRD49 -0.0107519600643009 0.882230614095884 -0.0708665508411199 0.036340821500152 MirTarget;miRanda -0.107859924884714 6.59740467704601e-07 NA NA NA hsa-miR-98-5p ANKRD49 0.0806971683871804 0.251777941211574 -0.0708665508411199 0.036340821500152 MirTarget -0.135907639088136 1.84420491027422e-11 NA NA NA hsa-miR-1-3p ANXA2 0.218035884810577 0.12519686250975 -0.784668900742557 1.73225362203604e-10 miRTarBase;MirTarget -0.104333893458792 0.00520678743037567 24310399 The mRNA encoding Annexin A2 ANXA2 one of the most abundant proteins in glioblastoma-derived extracellular vesicles was found to be a direct target of miR-1 control; In addition extracellular vesicle-derived miR-1 along with other ANXA2 extracellular vesicle networking partners targeted multiple pro-oncogenic signals in cells within the glioblastoma microenvironment glioblastoma hsa-miR-9-5p ANXA2 0.125377971246515 0.269896477801932 -0.784668900742557 1.73225362203604e-10 miRNATAP -1.12009858725095 2.36107627298484e-23 NA NA NA hsa-miR-106a-5p AR -0.110074064773885 0.130458159906254 -0.150947949527158 0.364688679402706 mirMAP -0.468933529909516 9.04848294688689e-06 NA NA NA hsa-miR-1179 AR 0.117056451908751 0.310989525634766 -0.150947949527158 0.364688679402706 mirMAP -0.434681958525962 7.94125216035519e-12 NA NA NA hsa-miR-124-3p AR 0.506026514549267 0.00780563703586767 -0.150947949527158 0.364688679402706 miRNAWalker2_validate;miRTarBase;miRNATAP -0.162401342533908 2.18788730878267e-05 25860954;26573802;23069658 Regulation and methylation of tumor suppressor miR 124 by androgen receptor in prostate cancer cells; However the relationship between AR and miR-124 is unclear; In the present study we found a negative feedback loop between AR and miR-124 expression; On one hand miR-124 was a positively regulated target gene of the AR on the other hand overexpression of miR-124 inhibited the expression of AR; Taken together our results support a negative feedback loop between AR and miR-124 expression;miR-124 targets the androgen receptor AR transcript acting as a tumor suppressor to broadly limit the growth of prostate cancer; miR-124 inhibited proliferation of prostate cancer cells in vitro and sensitized them to inhibitors of androgen receptor signaling;Tumor suppressive miR 124 targets androgen receptor and inhibits proliferation of prostate cancer cells ;; prostate cancer;prostate cancer;prostate cancer hsa-miR-146a-5p AR -0.148942451196266 0.114229072828761 -0.150947949527158 0.364688679402706 mirMAP -0.480372374185774 4.89720084186949e-10 25123132 To study the cellular response to miR-146a upregulation in p53-impaired basal-like lines antagomir KD of miR-146a was performed; KD of miR-146a caused decreased proliferation and increased apoptosis effectively ablating the effects of p53 loss drug resistance breast cancer hsa-miR-146b-5p AR -0.441078059667276 0.000237619929889549 -0.150947949527158 0.364688679402706 mirMAP -0.165465477388453 0.00931483659701464 NA NA NA hsa-miR-181b-5p AR -0.0260899284211344 0.768941836912778 -0.150947949527158 0.364688679402706 miRNATAP -0.235795413603044 0.0219209561722745 NA NA NA hsa-miR-19a-3p AR -0.0466707843731764 0.576818938277875 -0.150947949527158 0.364688679402706 mirMAP -0.355076617525011 9.75069522088578e-05 NA NA NA hsa-miR-19b-3p AR 0.013842745084812 0.856506310672867 -0.150947949527158 0.364688679402706 mirMAP -0.638240210153815 2.98164830678776e-09 NA NA NA hsa-miR-20a-5p AR 0.0115865752289119 0.887069448775761 -0.150947949527158 0.364688679402706 mirMAP -0.501058021488744 2.72264421992104e-06 NA NA NA hsa-miR-338-3p AR 0.399637046793888 0.00344106432206527 -0.150947949527158 0.364688679402706 miRanda -0.232732609491165 6.58321720952697e-05 NA NA NA hsa-miR-34c-5p AR -0.181931113688087 0.257266965617378 -0.150947949527158 0.364688679402706 MirTarget -0.166774735878871 0.000198945851305541 21343391 In particular analysis of clinical prostate cancers confirmed a negative correlation of miR-34a and miR-34c expression with AR levels prostate cancer hsa-miR-582-3p AR 0.118075891830139 0.304077332003561 -0.150947949527158 0.364688679402706 mirMAP -0.524556238333381 1.03695131148482e-16 NA NA NA hsa-miR-892a AR 0.242011750672214 0.136146245118017 -0.150947949527158 0.364688679402706 mirMAP -0.192278078345456 2.84737059192238e-05 NA NA NA hsa-miR-9-3p AR 0.184945845984739 0.0290051908008628 -0.150947949527158 0.364688679402706 MirTarget;miRNATAP -0.263090283717471 0.0249229513978786 NA NA NA hsa-miR-9-5p AR 0.125377971246515 0.269896477801932 -0.150947949527158 0.364688679402706 miRNATAP -0.661307641799773 3.31557715019366e-05 NA NA NA hsa-miR-125a-5p BCL2L13 0.0833349424517795 0.32544020025337 0.0373257060772776 0.405512707123629 miRanda;mirMAP -0.106547897725008 1.08624894850446e-08 NA NA NA hsa-miR-361-5p BCL2L13 -0.0107519600643009 0.882230614095884 0.0373257060772776 0.405512707123629 mirMAP -0.129783750493357 3.0685036183781e-09 NA NA NA hsa-miR-320a BMP6 -0.0921355996367019 0.243028758990046 -0.0108454108436198 0.909539532904516 PITA;miRanda -0.297182500566266 5.12161480673776e-06 NA NA NA hsa-miR-320b BMP6 -0.28347774630417 0.000595376302090892 -0.0108454108436198 0.909539532904516 PITA;miRanda -0.18169743142651 0.000264300273804033 NA NA NA hsa-miR-320c BMP6 -0.343259124189967 0.000248338401291042 -0.0108454108436198 0.909539532904516 PITA;miRanda -0.169559484719026 0.000173476089227076 NA NA NA hsa-miR-454-3p BMP6 -0.177318549827637 0.0120865170334474 -0.0108454108436198 0.909539532904516 MirTarget -0.231962895450268 0.000139683781737107 NA NA NA hsa-let-7a-2-3p CACNA1E -0.295235553592456 0.00290654476250626 0.569847771875024 9.69601679094519e-05 mirMAP -0.287063862993946 1.03599853519214e-05 NA NA NA hsa-let-7e-5p CACNA1E -0.0471189209570024 0.657255455444874 0.569847771875024 9.69601679094519e-05 miRNATAP -0.216929662389206 0.00224167794148438 NA NA NA hsa-let-7g-5p CACNA1E 0.025339633460872 0.742556489443337 0.569847771875024 9.69601679094519e-05 miRNATAP -0.256535263311808 0.0184330306694831 NA NA NA hsa-let-7i-5p CACNA1E -0.0952853587923013 0.192120688957357 0.569847771875024 9.69601679094519e-05 miRNATAP -0.683583147924187 5.30441139033797e-10 NA NA NA hsa-miR-106b-5p CACNA1E -0.167096183547595 0.0497544396383733 0.569847771875024 9.69601679094519e-05 mirMAP -0.314181252128203 0.000218911163229139 NA NA NA hsa-miR-125a-5p CACNA1E 0.0833349424517795 0.32544020025337 0.569847771875024 9.69601679094519e-05 miRanda -0.25326558543168 0.00660918419810706 NA NA NA hsa-miR-1266-5p CACNA1E -0.313515127917259 0.0138664194727391 0.569847771875024 9.69601679094519e-05 MirTarget -0.13832531085934 0.00618319796088083 NA NA NA hsa-miR-1271-5p CACNA1E -0.101224150198854 0.215169362708645 0.569847771875024 9.69601679094519e-05 mirMAP -0.206511864416747 0.00962322879946216 NA NA NA hsa-miR-130b-5p CACNA1E -0.413070888963574 1.98866876365723e-06 0.569847771875024 9.69601679094519e-05 miRNATAP -0.25972362720508 0.000608442089189108 NA NA NA hsa-miR-141-3p CACNA1E -0.411205619919922 0.000393344390969032 0.569847771875024 9.69601679094519e-05 MirTarget;TargetScan;miRNATAP -0.168253988146395 0.00268140052705055 NA NA NA hsa-miR-142-3p CACNA1E -0.558908907203953 1.37828834702525e-05 0.569847771875024 9.69601679094519e-05 miRanda -0.213331274653768 2.804988411466e-05 NA NA NA hsa-miR-142-5p CACNA1E -0.434884875454099 0.000575570345702933 0.569847771875024 9.69601679094519e-05 MirTarget;mirMAP -0.24116103994413 1.38920607167175e-06 NA NA NA hsa-miR-148a-3p CACNA1E -0.30682159249341 0.039235695888613 0.569847771875024 9.69601679094519e-05 mirMAP -0.167652351960226 0.000207832248744817 NA NA NA hsa-miR-148b-5p CACNA1E -0.127111784487802 0.188731110216915 0.569847771875024 9.69601679094519e-05 mirMAP -0.226726875696991 0.000722024568429348 NA NA NA hsa-miR-15a-5p CACNA1E -0.142658985373589 0.0536219185009377 0.569847771875024 9.69601679094519e-05 MirTarget -0.401567229323789 0.000121089223665663 NA NA NA hsa-miR-15b-5p CACNA1E -0.59286315669281 1.41971517354318e-10 0.569847771875024 9.69601679094519e-05 MirTarget -0.406003981601107 1.62327506079856e-08 NA NA NA hsa-miR-16-2-3p CACNA1E -0.468816222075622 7.04377763166223e-05 0.569847771875024 9.69601679094519e-05 mirMAP -0.151237156865141 0.0048394989937493 NA NA NA hsa-miR-16-5p CACNA1E -0.246024668671255 0.00346042804504067 0.569847771875024 9.69601679094519e-05 MirTarget -0.315570606736949 0.000434791502181832 NA NA NA hsa-miR-17-3p CACNA1E -0.0217768908350413 0.801140991374936 0.569847771875024 9.69601679094519e-05 miRNATAP -0.174443689063786 0.0405838868347125 NA NA NA hsa-miR-17-5p CACNA1E -0.097575136916686 0.206211102146113 0.569847771875024 9.69601679094519e-05 mirMAP -0.379941418688685 0.00021692220337652 NA NA NA hsa-miR-186-5p CACNA1E -0.060638189413023 0.514217717592655 0.569847771875024 9.69601679094519e-05 mirMAP -0.423872277345216 1.66972742898617e-08 NA NA NA hsa-miR-195-3p CACNA1E -0.10010545590307 0.133362389112373 0.569847771875024 9.69601679094519e-05 mirMAP -0.51126717527416 1.8439995092908e-07 NA NA NA hsa-miR-1976 CACNA1E -0.127074435034709 0.277235601775441 0.569847771875024 9.69601679094519e-05 mirMAP -0.130749650922801 0.016361105440468 NA NA NA hsa-miR-19a-3p CACNA1E -0.0466707843731764 0.576818938277875 0.569847771875024 9.69601679094519e-05 mirMAP -0.21200782890506 0.00828230504034734 NA NA NA hsa-miR-19b-3p CACNA1E 0.013842745084812 0.856506310672867 0.569847771875024 9.69601679094519e-05 mirMAP -0.246626989293808 0.0099777608695719 NA NA NA hsa-miR-20b-3p CACNA1E -0.362644372373259 0.000173241009721271 0.569847771875024 9.69601679094519e-05 mirMAP -0.144827071161125 0.0281570831856488 NA NA NA hsa-miR-21-5p CACNA1E -1.05049251753105 2.58081295984588e-11 0.569847771875024 9.69601679094519e-05 mirMAP -0.451889095936332 3.2593879420763e-25 NA NA NA hsa-miR-223-3p CACNA1E 0.0272428307561139 0.814395950305444 0.569847771875024 9.69601679094519e-05 mirMAP -0.117579738203023 0.0395016388432361 NA NA NA hsa-miR-28-5p CACNA1E -0.104003572105765 0.153594705579597 0.569847771875024 9.69601679094519e-05 mirMAP -0.453941553960938 1.39026685216558e-06 NA NA NA hsa-miR-3065-3p CACNA1E 0.261348288537912 0.0343753235107738 0.569847771875024 9.69601679094519e-05 MirTarget;miRNATAP -0.184510873255171 0.000655380617208557 NA NA NA hsa-miR-3065-5p CACNA1E 0.262608140481518 0.0414570974147947 0.569847771875024 9.69601679094519e-05 mirMAP -0.211752654453755 1.95893887942518e-05 NA NA NA hsa-miR-30a-3p CACNA1E -0.0655410309550497 0.509541256242263 0.569847771875024 9.69601679094519e-05 MirTarget;mirMAP;miRNATAP -0.312209053564724 0.000194472078194612 NA NA NA hsa-miR-30d-3p CACNA1E -0.0854049347792865 0.206912548011228 0.569847771875024 9.69601679094519e-05 MirTarget;mirMAP;miRNATAP -0.266218836446433 0.00532856101391993 NA NA NA hsa-miR-30e-3p CACNA1E -0.00173769765871867 0.98496550154767 0.569847771875024 9.69601679094519e-05 MirTarget;mirMAP;miRNATAP -0.311468848846731 0.00102794675931936 NA NA NA hsa-miR-3127-5p CACNA1E 0.0645479321229903 0.38233059120474 0.569847771875024 9.69601679094519e-05 MirTarget -0.238042388182824 0.00673085440749334 NA NA NA hsa-miR-320a CACNA1E -0.0921355996367019 0.243028758990046 0.569847771875024 9.69601679094519e-05 miRanda;miRNATAP -0.443542288672664 1.12948813993509e-05 NA NA NA hsa-miR-320b CACNA1E -0.28347774630417 0.000595376302090892 0.569847771875024 9.69601679094519e-05 miRanda;miRNATAP -0.368641431122113 1.57993697323939e-06 NA NA NA hsa-miR-320c CACNA1E -0.343259124189967 0.000248338401291042 0.569847771875024 9.69601679094519e-05 miRanda;miRNATAP -0.350768101709383 4.60203419189168e-07 NA NA NA hsa-miR-361-5p CACNA1E -0.0107519600643009 0.882230614095884 0.569847771875024 9.69601679094519e-05 miRanda -0.252018156551661 0.0216937343159483 NA NA NA hsa-miR-362-5p CACNA1E 0.0730185557229386 0.425572997292157 0.569847771875024 9.69601679094519e-05 mirMAP -0.171051494931987 0.0163402311343899 NA NA NA hsa-miR-374a-3p CACNA1E -0.176226170437582 0.0343958848425882 0.569847771875024 9.69601679094519e-05 mirMAP -0.511238407595226 7.39526818186029e-08 NA NA NA hsa-miR-374a-5p CACNA1E -0.0121037060909126 0.865417963346047 0.569847771875024 9.69601679094519e-05 mirMAP -0.321642877508947 0.000873806066982522 NA NA NA hsa-miR-421 CACNA1E 0.171573235029884 0.0518112933650958 0.569847771875024 9.69601679094519e-05 mirMAP -0.207353918884904 0.00442941171560841 NA NA NA hsa-miR-452-5p CACNA1E -0.599327068454216 1.02031931068513e-05 0.569847771875024 9.69601679094519e-05 mirMAP -0.369628629002967 3.8048786417053e-16 NA NA NA hsa-miR-497-5p CACNA1E 0.000783764887907878 0.991703566618646 0.569847771875024 9.69601679094519e-05 MirTarget -0.186064924367082 0.042049161660422 NA NA NA hsa-miR-502-3p CACNA1E -0.0276791089364163 0.69760501136877 0.569847771875024 9.69601679094519e-05 miRNATAP -0.307308129350793 0.000763772883406498 NA NA NA hsa-miR-505-3p CACNA1E -0.115486008167459 0.109833720698351 0.569847771875024 9.69601679094519e-05 mirMAP -0.471978633519725 3.80076787498887e-07 NA NA NA hsa-miR-505-5p CACNA1E -0.097300878501835 0.183209581426829 0.569847771875024 9.69601679094519e-05 mirMAP -0.309943365557148 0.000475085639919054 NA NA NA hsa-miR-548b-3p CACNA1E -0.340474544210108 0.00224491592019744 0.569847771875024 9.69601679094519e-05 mirMAP;miRNATAP -0.162511476052081 0.0051669515118279 NA NA NA hsa-miR-550a-3p CACNA1E -0.311518294008365 0.00152856404518866 0.569847771875024 9.69601679094519e-05 mirMAP -0.23518896433972 0.000283737985694508 NA NA NA hsa-miR-589-3p CACNA1E -0.00739371736361327 0.927768051649327 0.569847771875024 9.69601679094519e-05 mirMAP -0.295562299834388 0.000186700797499734 NA NA NA hsa-miR-590-3p CACNA1E -0.312951515438399 0.00048045542384394 0.569847771875024 9.69601679094519e-05 miRanda -0.40137141736604 1.25987141104387e-08 NA NA NA hsa-miR-590-5p CACNA1E -0.169460270359482 0.0386004382081766 0.569847771875024 9.69601679094519e-05 miRanda;mirMAP -0.367311213541456 2.91464229846951e-06 NA NA NA hsa-miR-629-3p CACNA1E -0.318874955109265 0.000626312848000462 0.569847771875024 9.69601679094519e-05 miRNATAP -0.356941391091919 1.60734779453386e-07 NA NA NA hsa-miR-708-5p CACNA1E 0.0093651971830333 0.91985767152436 0.569847771875024 9.69601679094519e-05 mirMAP -0.326376293472769 1.24885736417146e-05 NA NA NA hsa-miR-92a-1-5p CACNA1E -0.32438915788874 0.0012604129214261 0.569847771875024 9.69601679094519e-05 mirMAP -0.136481040721 0.0362693942593685 NA NA NA hsa-miR-93-5p CACNA1E -0.139766237971079 0.101057320076733 0.569847771875024 9.69601679094519e-05 mirMAP -0.473089603913452 4.1762044775939e-05 NA NA NA hsa-miR-942-5p CACNA1E -0.331570745524138 0.00475398014468333 0.569847771875024 9.69601679094519e-05 MirTarget -0.194333606958141 0.000413509679342321 NA NA NA hsa-miR-195-3p CALM1 -0.10010545590307 0.133362389112373 0.280032159940101 0.000416637554487524 mirMAP -0.134166818079922 0.00105978192797807 NA NA NA hsa-miR-19a-3p CALM1 -0.0466707843731764 0.576818938277875 0.280032159940101 0.000416637554487524 miRNATAP -0.15911303134072 1.46727029621246e-06 NA NA NA hsa-miR-19b-3p CALM1 0.013842745084812 0.856506310672867 0.280032159940101 0.000416637554487524 miRNATAP -0.185331239690791 2.55415494763863e-06 NA NA NA hsa-miR-423-5p CALM1 -0.0965587900813549 0.148039180704438 0.280032159940101 0.000416637554487524 miRNATAP -0.223655718300353 4.96731682524877e-07 NA NA NA hsa-miR-450b-5p CALM1 -0.270544879013982 0.00801537838499814 0.280032159940101 0.000416637554487524 PITA;miRNATAP -0.112486399533519 1.86205667354578e-05 NA NA NA hsa-miR-505-3p CALM1 -0.115486008167459 0.109833720698351 0.280032159940101 0.000416637554487524 mirMAP -0.104496375208374 0.00719334467208247 NA NA NA hsa-miR-339-5p CD24 -0.273253751377135 0.0185300170790711 0.21564654161547 0.130185886730239 miRanda -0.366865698904895 6.68925668941164e-13 NA NA NA hsa-miR-455-5p CD24 -0.332224239762001 0.0106491358056235 0.21564654161547 0.130185886730239 miRanda -0.341059871081097 6.23127393648106e-14 NA NA NA hsa-miR-496 CD24 0.139833482232875 0.395975418625328 0.21564654161547 0.130185886730239 miRanda -0.201484752890238 4.37433931273219e-08 NA NA NA hsa-miR-582-5p CD24 0.215764335500681 0.0760892640434293 0.21564654161547 0.130185886730239 MirTarget;PITA -0.203555819545136 3.43425395317339e-05 NA NA NA hsa-miR-766-3p CD24 0.147747825439882 0.266658981351484 0.21564654161547 0.130185886730239 MirTarget -0.351445778618354 1.16057920198098e-15 NA NA NA hsa-miR-128-3p CD276 0.781932174412697 7.18127563212596e-10 -0.460031392457725 1.14859333750124e-10 MirTarget -0.296123429308353 1.15638881012357e-39 NA NA NA hsa-miR-137 CD276 0.924849266740897 1.54683220204945e-06 -0.460031392457725 1.14859333750124e-10 miRanda -0.139636236808013 1.022323748499e-23 NA NA NA hsa-miR-29a-3p CD276 0.224140851576131 0.0349516103549852 -0.460031392457725 1.14859333750124e-10 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.221694684067992 1.0390098272475e-10 NA NA NA hsa-miR-29b-3p CD276 0.178522712044526 0.0856106432164969 -0.460031392457725 1.14859333750124e-10 MirTarget;miRNATAP -0.184498828016106 9.66342034925476e-10 NA NA NA hsa-miR-29c-3p CD276 0.37218039038731 0.00202634431972923 -0.460031392457725 1.14859333750124e-10 MirTarget;miRNATAP -0.189824070772179 5.86825037077953e-14 24577056 Identifying microRNAs regulating B7 H3 in breast cancer: the clinical impact of microRNA 29c breast cancer hsa-miR-326 CD276 0.631050656251066 8.83643450601628e-05 -0.460031392457725 1.14859333750124e-10 miRanda -0.127680542996902 6.89894135850923e-14 NA NA NA hsa-miR-330-3p CD276 0.427388106938161 0.003004892844142 -0.460031392457725 1.14859333750124e-10 mirMAP -0.117221338639073 1.24408404474415e-09 NA NA NA hsa-miR-330-5p CD276 0.262932095995619 0.0465226565966542 -0.460031392457725 1.14859333750124e-10 miRanda -0.110152199219768 2.2887414561088e-07 NA NA NA hsa-miR-338-3p CD276 0.399637046793888 0.00344106432206527 -0.460031392457725 1.14859333750124e-10 miRanda -0.183490757323008 1.09756250509587e-16 NA NA NA hsa-miR-767-5p CD276 0.551653504513127 2.61109058245e-05 -0.460031392457725 1.14859333750124e-10 miRNATAP -0.150249767031217 2.70413604822569e-12 NA NA NA hsa-miR-124-3p CDCA7 0.506026514549267 0.00780563703586767 -0.568653806280932 1.51192072274824e-07 miRNAWalker2_validate;MirTarget -0.13504169829215 5.5575936875669e-08 NA NA NA hsa-miR-139-5p CDCA7 0.647754756897662 2.1537830723695e-06 -0.568653806280932 1.51192072274824e-07 miRanda -0.287353658962981 1.65983210561943e-16 NA NA NA hsa-miR-140-3p CDCA7 0.123864258867744 0.147966866194363 -0.568653806280932 1.51192072274824e-07 MirTarget -0.30935748290041 2.48493638769501e-05 NA NA NA hsa-miR-24-3p CDCA7 -0.133257261462843 0.212960921400951 -0.568653806280932 1.51192072274824e-07 miRNAWalker2_validate -0.148449175140022 0.00267510680600177 NA NA NA hsa-miR-299-5p CDCA7 0.0814737109317376 0.576202442267832 -0.568653806280932 1.51192072274824e-07 MirTarget -0.169091205408061 2.4998997199662e-07 NA NA NA hsa-miR-30b-5p CDCA7 0.085810101632239 0.263243418521696 -0.568653806280932 1.51192072274824e-07 miRNAWalker2_validate;MirTarget -0.323069442440143 1.47707502158683e-05 NA NA NA hsa-miR-30d-5p CDCA7 0.0607010868720561 0.471410043548418 -0.568653806280932 1.51192072274824e-07 MirTarget -0.285358941220593 0.000866869550338958 NA NA NA hsa-miR-496 CDCA7 0.139833482232875 0.395975418625328 -0.568653806280932 1.51192072274824e-07 miRanda -0.133426168997932 4.55249594441393e-06 NA NA NA hsa-miR-543 CDCA7 0.347737549779626 0.0157394585079679 -0.568653806280932 1.51192072274824e-07 miRanda -0.176023984986778 1.43124127183458e-07 NA NA NA hsa-miR-26b-5p CELF1 0.0984536538763106 0.231803769574464 -0.00701580781427502 0.886752900944976 mirMAP;miRNATAP -0.103045700447487 1.78298333929101e-07 NA NA NA hsa-miR-30a-5p CELF1 0.0629429366112948 0.513851954699872 -0.00701580781427502 0.886752900944976 mirMAP;miRNATAP -0.120750255534278 2.10298438945186e-07 NA NA NA hsa-miR-30c-5p CELF1 0.0469114469943488 0.565934557464302 -0.00701580781427502 0.886752900944976 mirMAP;miRNATAP -0.125268909601078 4.43057091307708e-09 NA NA NA hsa-let-7a-3p CLIP1 -0.0530563276543585 0.370749834463726 -0.0230208575525488 0.68652196981494 miRNATAP -0.178964875887401 2.82518031144703e-06 NA NA NA hsa-miR-19a-3p CLIP1 -0.0466707843731764 0.576818938277875 -0.0230208575525488 0.68652196981494 miRNATAP -0.134463806074857 1.02294743324351e-07 NA NA NA hsa-miR-19b-3p CLIP1 0.013842745084812 0.856506310672867 -0.0230208575525488 0.68652196981494 miRNAWalker2_validate;miRNATAP -0.206953692048954 3.98499524912109e-12 NA NA NA hsa-miR-320a CLIP1 -0.0921355996367019 0.243028758990046 -0.0230208575525488 0.68652196981494 miRanda -0.121148434306397 0.000167073090328646 NA NA NA hsa-miR-454-3p CLIP1 -0.177318549827637 0.0120865170334474 -0.0230208575525488 0.68652196981494 MirTarget;miRNATAP -0.144954919692812 1.19836387832347e-06 NA NA NA hsa-miR-124-3p CMTM3 0.506026514549267 0.00780563703586767 -0.446058376750553 2.1993505442924e-10 miRNAWalker2_validate -0.172667472798909 3.55653692146944e-34 NA NA NA hsa-miR-129-5p CMTM3 0.567133990117154 0.00116152215679873 -0.446058376750553 2.1993505442924e-10 miRanda -0.186300470244788 2.95889291886412e-32 NA NA NA hsa-miR-132-3p CMTM3 0.178379362833879 0.133352008771241 -0.446058376750553 2.1993505442924e-10 miRNAWalker2_validate -0.220399970720481 4.81707705994845e-19 NA NA NA hsa-miR-137 CMTM3 0.924849266740897 1.54683220204945e-06 -0.446058376750553 2.1993505442924e-10 miRanda -0.139787942385405 3.23153920090256e-23 NA NA NA hsa-miR-149-5p CMTM3 0.0535821592030219 0.65771389201239 -0.446058376750553 2.1993505442924e-10 MirTarget -0.109428629956091 5.56162570690692e-06 NA NA NA hsa-miR-370-3p CMTM3 0.200869919920804 0.200763627682567 -0.446058376750553 2.1993505442924e-10 MirTarget -0.133664566914778 6.21265369473576e-14 NA NA NA hsa-let-7a-3p CNR1 -0.0530563276543585 0.370749834463726 -0.199934594169825 0.107809477504065 mirMAP -0.546635149700781 7.67647975997642e-08 NA NA NA hsa-miR-3065-5p CNR1 0.262608140481518 0.0414570974147947 -0.199934594169825 0.107809477504065 mirMAP -0.166231468209311 8.00524732192811e-05 NA NA NA hsa-miR-125a-3p DISC1 -0.183834985432375 0.106230647107919 -0.213324547470039 0.00796912338050828 miRanda -0.115169149357542 0.000118774146505135 NA NA NA hsa-miR-148b-3p DISC1 -0.0710353380371309 0.322794068460372 -0.213324547470039 0.00796912338050828 mirMAP -0.14488321339345 0.00763154797118415 NA NA NA hsa-miR-20a-3p DISC1 -0.102743778777987 0.196778653597552 -0.213324547470039 0.00796912338050828 mirMAP -0.110512281259571 0.0101998187618438 NA NA NA hsa-miR-2355-3p DISC1 -0.186207523505298 0.0525918026992985 -0.213324547470039 0.00796912338050828 mirMAP -0.103534193734994 0.00310440435322923 NA NA NA hsa-miR-28-3p DISC1 -0.139444423970973 0.0811187936165283 -0.213324547470039 0.00796912338050828 mirMAP -0.124427470242751 0.0233359245990443 NA NA NA hsa-miR-28-5p DISC1 -0.104003572105765 0.153594705579597 -0.213324547470039 0.00796912338050828 miRanda -0.111744521136882 0.0256088709569385 NA NA NA hsa-miR-29a-5p DISC1 0.0697727833812762 0.350621682973061 -0.213324547470039 0.00796912338050828 mirMAP -0.316927549094348 2.58856941703918e-12 NA NA NA hsa-miR-324-5p DISC1 -0.0183370482495828 0.842996782677376 -0.213324547470039 0.00796912338050828 miRanda -0.151985357989697 4.39126697418018e-05 NA NA NA hsa-miR-339-5p DISC1 -0.273253751377135 0.0185300170790711 -0.213324547470039 0.00796912338050828 miRanda -0.108102037457853 0.000195082869432228 NA NA NA hsa-miR-342-3p DISC1 0.125683829770898 0.105810751640081 -0.213324547470039 0.00796912338050828 miRanda -0.276643032893545 9.63965104783323e-09 NA NA NA hsa-miR-361-5p DISC1 -0.0107519600643009 0.882230614095884 -0.213324547470039 0.00796912338050828 miRanda -0.255149288459795 9.20676640071091e-06 NA NA NA hsa-miR-374a-5p DISC1 -0.0121037060909126 0.865417963346047 -0.213324547470039 0.00796912338050828 mirMAP -0.182472542214581 0.000341782540407677 NA NA NA hsa-miR-374b-5p DISC1 0.210113949579637 0.00568660838185483 -0.213324547470039 0.00796912338050828 mirMAP -0.27139439342041 5.46083309695567e-08 NA NA NA hsa-miR-532-5p DISC1 -0.0263466708636777 0.757630060399045 -0.213324547470039 0.00796912338050828 mirMAP -0.109507758295347 0.0236696169355943 NA NA NA hsa-miR-589-3p DISC1 -0.00739371736361327 0.927768051649327 -0.213324547470039 0.00796912338050828 mirMAP -0.229073352556664 3.17441371800984e-08 NA NA NA hsa-miR-590-5p DISC1 -0.169460270359482 0.0386004382081766 -0.213324547470039 0.00796912338050828 miRanda -0.197099858438538 1.95806800447468e-06 NA NA NA hsa-miR-760 DISC1 0.137843834465103 0.266726472033799 -0.213324547470039 0.00796912338050828 miRNATAP -0.114554322807278 2.15238442774744e-05 NA NA NA hsa-let-7c-5p DUSP7 0.0429585188677333 0.676052842748313 0.15382311609006 0.00405709205994286 miRNAWalker2_validate -0.139727286666787 2.09622891852266e-07 NA NA NA hsa-let-7a-5p E2F2 -0.00220017218199509 0.982661524826928 -1.34827244761579 5.91940938359588e-17 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.268135493823604 0.0237685009087083 20418948;25647078 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2;Tumor suppressive microRNA let 7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells; When let-7a was transfected into OS cell lines the expression of E2F2 in the cells was greatly suppressed suggesting that E2F2 is a target of miRNA-let-7a in OS cells ; prostate cancer;sarcoma hsa-let-7b-5p E2F2 -0.03621838521825 0.719557004564834 -1.34827244761579 5.91940938359588e-17 MirTarget -0.223238828641775 0.0304434124452438 NA NA NA hsa-let-7e-5p E2F2 -0.0471189209570024 0.657255455444874 -1.34827244761579 5.91940938359588e-17 MirTarget -0.227577637619613 0.00488223035838476 NA NA NA hsa-let-7g-5p E2F2 0.025339633460872 0.742556489443337 -1.34827244761579 5.91940938359588e-17 MirTarget -0.273787033693133 0.0271788276056673 NA NA NA hsa-miR-125a-5p E2F2 0.0833349424517795 0.32544020025337 -1.34827244761579 5.91940938359588e-17 MirTarget -0.461569157612989 1.22786103450127e-05 NA NA NA hsa-miR-185-3p E2F2 0.133219014400352 0.25571381872824 -1.34827244761579 5.91940938359588e-17 MirTarget -0.221464640291927 0.000349011855987302 NA NA NA hsa-miR-193b-3p E2F2 -0.0766333116223921 0.324723824453239 -1.34827244761579 5.91940938359588e-17 miRNAWalker2_validate -0.38514640995334 8.96744661984587e-05 NA NA NA hsa-miR-204-5p E2F2 0.288588537398083 0.113371226435799 -1.34827244761579 5.91940938359588e-17 mirMAP -0.167962539797751 2.56052343338108e-05 NA NA NA hsa-miR-22-3p E2F2 -0.0277287593465747 0.809325106833056 -1.34827244761579 5.91940938359588e-17 miRNAWalker2_validate -0.593831337538519 5.84089457404813e-12 NA NA NA hsa-miR-2355-5p E2F2 -0.00808596988209409 0.91616550115528 -1.34827244761579 5.91940938359588e-17 mirMAP -0.228019387623926 0.022640487206504 NA NA NA hsa-miR-26a-5p E2F2 -0.033823776747262 0.726610414342617 -1.34827244761579 5.91940938359588e-17 miRNATAP -0.238946953225521 0.00899757878295909 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-26b-5p E2F2 0.0984536538763106 0.231803769574464 -1.34827244761579 5.91940938359588e-17 miRNATAP -0.279929616122037 0.00833489565893885 NA NA NA hsa-miR-30c-2-3p E2F2 0.186305604188082 0.0313113706136341 -1.34827244761579 5.91940938359588e-17 MirTarget -0.531057578005903 4.73180385011406e-09 NA NA NA hsa-miR-326 E2F2 0.631050656251066 8.83643450601628e-05 -1.34827244761579 5.91940938359588e-17 MirTarget -0.280624262853395 2.00326576109166e-10 NA NA NA hsa-miR-330-5p E2F2 0.262932095995619 0.0465226565966542 -1.34827244761579 5.91940938359588e-17 MirTarget;miRNATAP -0.346942874107683 1.70115694039137e-10 NA NA NA hsa-miR-331-3p E2F2 -0.0126984726684007 0.905175053957109 -1.34827244761579 5.91940938359588e-17 miRNAWalker2_validate -0.22862799370917 0.000950309250903931 NA NA NA hsa-miR-338-3p E2F2 0.399637046793888 0.00344106432206527 -1.34827244761579 5.91940938359588e-17 mirMAP -0.33969687934866 4.05953795332898e-09 NA NA NA hsa-miR-365a-3p E2F2 0.184222766207935 0.0292663235724032 -1.34827244761579 5.91940938359588e-17 MirTarget -0.455918727958444 1.98971122282273e-07 NA NA NA hsa-miR-378c E2F2 -0.169076160997046 0.114131854194067 -1.34827244761579 5.91940938359588e-17 MirTarget -0.292046160835513 2.37761097277519e-05 NA NA NA hsa-miR-432-5p E2F2 0.214242438141989 0.166186087759922 -1.34827244761579 5.91940938359588e-17 mirMAP -0.169394779115155 0.0002959313864057 NA NA NA hsa-miR-488-3p E2F2 0.257955761012583 0.00280795162806105 -1.34827244761579 5.91940938359588e-17 mirMAP -0.500491651618079 4.21227626758742e-09 NA NA NA hsa-miR-490-3p E2F2 0.834268051506887 5.26203010743174e-06 -1.34827244761579 5.91940938359588e-17 mirMAP -0.262096603370546 2.67497437024177e-11 NA NA NA hsa-miR-496 E2F2 0.139833482232875 0.395975418625328 -1.34827244761579 5.91940938359588e-17 miRanda -0.176222529328534 7.85797264595003e-05 NA NA NA hsa-miR-539-5p E2F2 0.326485413953599 0.0554453076411236 -1.34827244761579 5.91940938359588e-17 mirMAP -0.212027643333352 5.03744244110982e-07 NA NA NA hsa-miR-625-5p E2F2 0.0264137834407144 0.802098211251159 -1.34827244761579 5.91940938359588e-17 mirMAP -0.217792841278429 0.00170029040977415 NA NA NA hsa-miR-628-5p E2F2 0.0469793532266003 0.657420003383612 -1.34827244761579 5.91940938359588e-17 mirMAP -0.317783864402383 5.36506329866132e-06 NA NA NA hsa-miR-7-5p E2F2 0.244254069762737 0.193173919522098 -1.34827244761579 5.91940938359588e-17 miRNAWalker2_validate -0.154333499014073 8.78572177240792e-05 NA NA NA hsa-miR-766-3p E2F2 0.147747825439882 0.266658981351484 -1.34827244761579 5.91940938359588e-17 mirMAP -0.359513756029547 1.55793767609969e-11 NA NA NA hsa-miR-98-5p E2F2 0.0806971683871804 0.251777941211574 -1.34827244761579 5.91940938359588e-17 miRNAWalker2_validate;miRTarBase;MirTarget -0.241387150473327 0.0403592443366244 NA NA NA hsa-miR-124-3p ELF4 0.506026514549267 0.00780563703586767 -0.583882876626198 9.77650691380973e-09 miRNAWalker2_validate -0.148542529143435 1.93922651605207e-10 NA NA NA hsa-miR-488-5p ELF4 0.385755602369062 7.99431673275187e-08 -0.583882876626198 9.77650691380973e-09 MirTarget -0.173658973630813 0.00766498202414281 NA NA NA hsa-miR-130a-3p ERBB4 -0.163798739071218 0.0312594912163825 0.451153603222775 0.000206872762413717 miRNATAP -0.17648895968195 0.019440285172855 NA NA NA hsa-miR-130b-3p ERBB4 -0.503911467685704 9.4659058895114e-08 0.451153603222775 0.000206872762413717 miRNATAP -0.31346517305362 8.77707732663717e-09 NA NA NA hsa-miR-130b-5p ERBB4 -0.413070888963574 1.98866876365723e-06 0.451153603222775 0.000206872762413717 miRNATAP -0.239498289427459 7.70171710367112e-05 NA NA NA hsa-miR-146a-5p ERBB4 -0.148942451196266 0.114229072828761 0.451153603222775 0.000206872762413717 miRNAWalker2_validate;miRTarBase;miRNATAP -0.140631294205099 0.0107204241989775 NA NA NA hsa-miR-146b-5p ERBB4 -0.441078059667276 0.000237619929889549 0.451153603222775 0.000206872762413717 PITA;miRNATAP -0.195176888584798 1.14102304383699e-05 NA NA NA hsa-miR-155-5p ERBB4 -0.969837380981077 5.86551495710366e-15 0.451153603222775 0.000206872762413717 mirMAP -0.230667817051629 6.29742357764107e-09 NA NA NA hsa-miR-199a-3p ERBB4 -0.412263318710744 0.000497136154474781 0.451153603222775 0.000206872762413717 PITA;miRNATAP -0.111420920938682 0.0111011399699174 NA NA NA hsa-miR-199a-5p ERBB4 -0.174889610847956 0.0900027418912677 0.451153603222775 0.000206872762413717 PITA;miRNATAP -0.120323708976781 0.0170490654835085 NA NA NA hsa-miR-199b-3p ERBB4 -0.411848361704378 0.000517815011892612 0.451153603222775 0.000206872762413717 PITA;miRNATAP -0.110420020966829 0.0116593022534638 NA NA NA hsa-miR-199b-5p ERBB4 -0.436298593972863 0.00200225454383867 0.451153603222775 0.000206872762413717 PITA;miRNATAP -0.130145469755469 0.000299673604273439 NA NA NA hsa-miR-19a-3p ERBB4 -0.0466707843731764 0.576818938277875 0.451153603222775 0.000206872762413717 miRNAWalker2_validate;miRTarBase;miRNATAP -0.203512031605689 0.00153035119738689 NA NA NA hsa-miR-19b-3p ERBB4 0.013842745084812 0.856506310672867 0.451153603222775 0.000206872762413717 miRNATAP -0.32037280261742 2.66260698283197e-05 NA NA NA hsa-miR-27a-5p ERBB4 -0.588526581446 1.44259383783548e-07 0.451153603222775 0.000206872762413717 miRNATAP -0.229461644285517 3.90938982661046e-07 NA NA NA hsa-miR-362-3p ERBB4 -0.032375035235532 0.736465332563774 0.451153603222775 0.000206872762413717 PITA -0.107933436350888 0.0437619229492361 NA NA NA hsa-miR-450b-5p ERBB4 -0.270544879013982 0.00801537838499814 0.451153603222775 0.000206872762413717 mirMAP -0.210051610584431 3.53422208434111e-05 NA NA NA hsa-miR-542-3p ERBB4 -0.0835995677900652 0.403838744494172 0.451153603222775 0.000206872762413717 MirTarget -0.246969056607352 1.20944477895327e-05 NA NA NA hsa-miR-590-3p ERBB4 -0.312951515438399 0.00048045542384394 0.451153603222775 0.000206872762413717 miRanda;mirMAP -0.140369350487007 0.0141263334254537 NA NA NA hsa-miR-592 ERBB4 -0.0170005651576393 0.876633091134892 0.451153603222775 0.000206872762413717 mirMAP -0.185561176603718 7.21413113815264e-05 NA NA NA hsa-miR-664a-3p ERBB4 -0.0413918462466984 0.611334357897205 0.451153603222775 0.000206872762413717 mirMAP -0.138596559753844 0.0325339745796226 NA NA NA hsa-miR-96-5p ERBB4 0.217255611810236 0.209932800103882 0.451153603222775 0.000206872762413717 TargetScan -0.158860834465563 7.31202767377352e-08 NA NA NA hsa-miR-195-5p EYA4 0.00728332132633103 0.929698505775945 -0.779383541891705 0.000146399498143779 MirTarget -0.27254621108168 0.0219676851617759 NA NA NA hsa-miR-497-5p EYA4 0.000783764887907878 0.991703566618646 -0.779383541891705 0.000146399498143779 MirTarget -0.289389964919878 0.025233520612599 NA NA NA hsa-miR-767-3p EYA4 0.429854368420513 0.000821445291167693 -0.779383541891705 0.000146399498143779 PITA -0.380402135340371 9.53894144560883e-08 NA NA NA hsa-miR-767-5p EYA4 0.551653504513127 2.61109058245e-05 -0.779383541891705 0.000146399498143779 MirTarget -0.438128657004595 1.93455636621056e-10 NA NA NA hsa-miR-9-3p EYA4 0.184945845984739 0.0290051908008628 -0.779383541891705 0.000146399498143779 mirMAP;miRNATAP -1.09435661970248 1.21632897640048e-14 NA NA NA hsa-miR-126-5p F2R -0.177332403948646 0.0711675116243408 -0.400354991431698 3.54417987717176e-05 mirMAP -0.124486817048792 0.00355764151759715 NA NA NA hsa-miR-129-5p F2R 0.567133990117154 0.00116152215679873 -0.400354991431698 3.54417987717176e-05 MirTarget;miRanda;mirMAP -0.191278042800133 3.69845010505105e-17 NA NA NA hsa-miR-136-5p F2R 0.0792119620142637 0.5815913690357 -0.400354991431698 3.54417987717176e-05 mirMAP -0.149236559361107 8.96909130770332e-08 NA NA NA hsa-miR-190a-5p F2R 0.0574993923869489 0.534047621516076 -0.400354991431698 3.54417987717176e-05 MirTarget -0.208802529826502 1.26136752565094e-06 NA NA NA hsa-miR-23b-3p F2R -0.0476610245859863 0.630277683372509 -0.400354991431698 3.54417987717176e-05 MirTarget -0.184311507990793 4.47367266798835e-05 NA NA NA hsa-miR-29a-5p F2R 0.0697727833812762 0.350621682973061 -0.400354991431698 3.54417987717176e-05 MirTarget -0.229670391555577 2.51626597490675e-05 NA NA NA hsa-miR-342-5p F2R -0.0383784541944334 0.544128449296234 -0.400354991431698 3.54417987717176e-05 MirTarget -0.291231198194674 6.55865586429551e-06 NA NA NA hsa-miR-361-5p F2R -0.0107519600643009 0.882230614095884 -0.400354991431698 3.54417987717176e-05 miRanda -0.293276364207239 1.7428662697287e-05 NA NA NA hsa-miR-491-5p F2R 0.749881113074991 8.22859263178918e-09 -0.400354991431698 3.54417987717176e-05 miRanda -0.266852866041892 4.57960731528225e-20 NA NA NA hsa-miR-577 F2R 0.382068371859265 0.0145513192729146 -0.400354991431698 3.54417987717176e-05 MirTarget;miRNATAP -0.105310292041066 4.19189349609004e-05 NA NA NA hsa-miR-582-5p F2R 0.215764335500681 0.0760892640434293 -0.400354991431698 3.54417987717176e-05 MirTarget -0.248500916960507 6.40302249956472e-15 NA NA NA hsa-miR-655-3p F2R 0.241086974063522 0.0960363954844231 -0.400354991431698 3.54417987717176e-05 MirTarget -0.200748138390222 1.42272251885738e-13 NA NA NA hsa-miR-664a-3p F2R -0.0413918462466984 0.611334357897205 -0.400354991431698 3.54417987717176e-05 mirMAP -0.258281000332276 2.57275049529991e-07 NA NA NA hsa-miR-15a-5p FASN -0.142658985373589 0.0536219185009377 0.246454699300484 0.00073565921385357 miRNAWalker2_validate;MirTarget -0.181231828479866 1.48003247339845e-05 27713175 Both miR-15a and miR-16-1 contributes to inhibiting FASN expression and breast cancer cell proliferation; In conclusion we demonstrated that FASN expression is primarily downregulated by miR-15a and miR-16-1 in mammary cells and FASN is one of the major targets of these two tumor suppressive microRNAs breast cancer hsa-miR-15b-5p FASN -0.59286315669281 1.41971517354318e-10 0.246454699300484 0.00073565921385357 MirTarget -0.125922690691939 1.43339184769635e-05 NA NA NA hsa-miR-16-5p FASN -0.246024668671255 0.00346042804504067 0.246454699300484 0.00073565921385357 MirTarget -0.112681615685463 0.00176734892556463 27713175 Both miR-15a and miR-16-1 contributes to inhibiting FASN expression and breast cancer cell proliferation; In conclusion we demonstrated that FASN expression is primarily downregulated by miR-15a and miR-16-1 in mammary cells and FASN is one of the major targets of these two tumor suppressive microRNAs breast cancer hsa-miR-186-5p FASN -0.060638189413023 0.514217717592655 0.246454699300484 0.00073565921385357 miRNAWalker2_validate -0.269615956239122 4.85289364674218e-20 NA NA NA hsa-miR-197-3p FASN 0.176796295244346 0.0837698554788909 0.246454699300484 0.00073565921385357 miRNAWalker2_validate -0.140805732028082 7.09872086398643e-07 NA NA NA hsa-miR-222-3p FASN -0.107117065575191 0.423818119725726 0.246454699300484 0.00073565921385357 miRNAWalker2_validate -0.100277828106586 1.15368166783966e-07 NA NA NA hsa-miR-26a-5p FASN -0.033823776747262 0.726610414342617 0.246454699300484 0.00073565921385357 miRNAWalker2_validate -0.176011728310366 3.38494667821167e-08 NA NA NA hsa-miR-27a-3p FASN -0.30376003289577 0.00457375391190104 0.246454699300484 0.00073565921385357 miRNATAP -0.274375341688552 5.18204313139723e-29 NA NA NA hsa-miR-27b-3p FASN 0.0599187745243448 0.582081434759731 0.246454699300484 0.00073565921385357 miRNAWalker2_validate;miRNATAP -0.154335630563924 2.03997132009842e-09 NA NA NA hsa-miR-423-3p FASN -0.192317829125863 0.00125622290742463 0.246454699300484 0.00073565921385357 miRNAWalker2_validate -0.197390075796699 0.000174764038758387 NA NA NA hsa-miR-484 FASN 0.0190828819137927 0.802298900989454 0.246454699300484 0.00073565921385357 miRNAWalker2_validate -0.166986550545918 3.45384440712498e-06 NA NA NA hsa-miR-92b-3p FASN 0.213968504162006 0.0523921855715249 0.246454699300484 0.00073565921385357 miRNAWalker2_validate -0.229410379731762 2.38737041222551e-18 NA NA NA hsa-miR-93-5p FASN -0.139766237971079 0.101057320076733 0.246454699300484 0.00073565921385357 miRNAWalker2_validate -0.180209551064904 0.000101593352125122 NA NA NA hsa-miR-942-5p FASN -0.331570745524138 0.00475398014468333 0.246454699300484 0.00073565921385357 miRNAWalker2_validate -0.118120036798342 6.98620623161292e-08 NA NA NA hsa-miR-139-5p FN1 0.647754756897662 2.1537830723695e-06 -0.611643203379501 4.13939447375655e-09 miRanda -0.251483354032568 4.44995418646961e-16 NA NA NA hsa-miR-9-3p FN1 0.184945845984739 0.0290051908008628 -0.611643203379501 4.13939447375655e-09 MirTarget -0.423766015725708 2.33822633132945e-10 NA NA NA hsa-let-7a-3p GCLM -0.0530563276543585 0.370749834463726 -0.139650440743542 0.0325749974505831 mirMAP -0.119366480699291 0.0222204037162429 NA NA NA hsa-miR-19b-3p GCLM 0.013842745084812 0.856506310672867 -0.139650440743542 0.0325749974505831 mirMAP -0.128470708884006 0.0018046929681988 NA NA NA hsa-miR-20a-5p GCLM 0.0115865752289119 0.887069448775761 -0.139650440743542 0.0325749974505831 mirMAP -0.161703513800906 6.53972930435181e-05 NA NA NA hsa-miR-17-5p GNB5 -0.097575136916686 0.206211102146113 0.17698752776019 0.00848636179514833 TargetScan -0.171125811929169 7.57887177376407e-05 NA NA NA hsa-miR-26b-5p GNB5 0.0984536538763106 0.231803769574464 0.17698752776019 0.00848636179514833 miRNAWalker2_validate -0.15088278412361 0.000115102305086069 NA NA NA hsa-miR-27a-3p GNB5 -0.30376003289577 0.00457375391190104 0.17698752776019 0.00848636179514833 miRNAWalker2_validate -0.189689297874063 1.15859987745694e-12 NA NA NA hsa-miR-542-3p GNB5 -0.0835995677900652 0.403838744494172 0.17698752776019 0.00848636179514833 miRanda -0.147022743558303 6.85906650308223e-07 NA NA NA hsa-miR-590-3p GNB5 -0.312951515438399 0.00048045542384394 0.17698752776019 0.00848636179514833 miRanda -0.16141535470045 5.80090806605299e-08 NA NA NA hsa-miR-106b-5p GPR26 -0.167096183547595 0.0497544396383733 0.707876408030311 0.0158420582674607 mirMAP -0.457489591480635 0.00774030029471249 NA NA NA hsa-miR-16-1-3p GPR26 -0.346674816118499 1.8644785016764e-05 0.707876408030311 0.0158420582674607 mirMAP -0.353238694624109 0.0275513388935181 NA NA NA hsa-miR-17-5p GPR26 -0.097575136916686 0.206211102146113 0.707876408030311 0.0158420582674607 mirMAP -0.487392022064644 0.0189829509457738 NA NA NA hsa-miR-19a-3p GPR26 -0.0466707843731764 0.576818938277875 0.707876408030311 0.0158420582674607 mirMAP -0.513711211606039 0.00147041838814666 NA NA NA hsa-miR-19b-3p GPR26 0.013842745084812 0.856506310672867 0.707876408030311 0.0158420582674607 mirMAP -0.451096267973892 0.0193870345485629 NA NA NA hsa-miR-25-3p GPR26 -0.316649850160946 0.000777982468388745 0.707876408030311 0.0158420582674607 mirMAP -0.370599799140843 0.0387930587123036 NA NA NA hsa-miR-3065-5p GPR26 0.262608140481518 0.0414570974147947 0.707876408030311 0.0158420582674607 mirMAP -0.504533467423725 4.032337567779e-07 NA NA NA hsa-miR-320a GPR26 -0.0921355996367019 0.243028758990046 0.707876408030311 0.0158420582674607 mirMAP -1.15291019661641 1.19267362442242e-08 NA NA NA hsa-miR-320b GPR26 -0.28347774630417 0.000595376302090892 0.707876408030311 0.0158420582674607 mirMAP -0.640408798406545 3.65841546815767e-05 NA NA NA hsa-miR-320c GPR26 -0.343259124189967 0.000248338401291042 0.707876408030311 0.0158420582674607 mirMAP -0.818457378651157 4.49712487809094e-09 NA NA NA hsa-miR-374a-5p GPR26 -0.0121037060909126 0.865417963346047 0.707876408030311 0.0158420582674607 mirMAP -0.622689220741695 0.00138823815194678 NA NA NA hsa-miR-450b-5p GPR26 -0.270544879013982 0.00801537838499814 0.707876408030311 0.0158420582674607 mirMAP -0.513553224809908 5.85243781454827e-05 NA NA NA hsa-miR-452-5p GPR26 -0.599327068454216 1.02031931068513e-05 0.707876408030311 0.0158420582674607 mirMAP -0.352840412730904 0.000166255978457531 NA NA NA hsa-miR-501-5p GPR26 -0.0878951859817464 0.309663377222435 0.707876408030311 0.0158420582674607 mirMAP -0.322114689803827 0.0318268922466342 NA NA NA hsa-miR-505-5p GPR26 -0.097300878501835 0.183209581426829 0.707876408030311 0.0158420582674607 mirMAP -0.480329589918619 0.00732532078372482 NA NA NA hsa-miR-550a-5p GPR26 -0.44674257664177 3.20431264038783e-06 0.707876408030311 0.0158420582674607 mirMAP -0.507119035694932 0.000140113796163708 NA NA NA hsa-miR-590-3p GPR26 -0.312951515438399 0.00048045542384394 0.707876408030311 0.0158420582674607 mirMAP -0.544949461091646 0.000142824882263292 NA NA NA hsa-miR-708-3p GPR26 -0.00458267260361467 0.962455132950912 0.707876408030311 0.0158420582674607 mirMAP -0.370300515330077 0.0124492572627511 NA NA NA hsa-miR-92b-3p GPR26 0.213968504162006 0.0523921855715249 0.707876408030311 0.0158420582674607 mirMAP -0.453933735434854 0.000839899957219537 NA NA NA hsa-miR-93-5p GPR26 -0.139766237971079 0.101057320076733 0.707876408030311 0.0158420582674607 mirMAP -0.961760826644796 3.54292655554861e-05 NA NA NA hsa-let-7b-5p HLF -0.03621838521825 0.719557004564834 0.569668903325758 1.16746221414536e-09 miRNATAP -0.121376331084752 0.030986045745447 NA NA NA hsa-let-7i-5p HLF -0.0952853587923013 0.192120688957357 0.569668903325758 1.16746221414536e-09 miRNATAP -0.215798117583892 0.00184384180051173 NA NA NA hsa-miR-106b-5p HLF -0.167096183547595 0.0497544396383733 0.569668903325758 1.16746221414536e-09 MirTarget;miRNATAP -0.338927016437105 7.54511185579703e-11 NA NA NA hsa-miR-1262 HLF -0.276259331706731 0.0259799942226561 0.569668903325758 1.16746221414536e-09 MirTarget;PITA;miRNATAP -0.247371423326003 7.70853646743868e-15 NA NA NA hsa-miR-141-3p HLF -0.411205619919922 0.000393344390969032 0.569668903325758 1.16746221414536e-09 TargetScan -0.133634692774123 0.000117763848772425 NA NA NA hsa-miR-16-1-3p HLF -0.346674816118499 1.8644785016764e-05 0.569668903325758 1.16746221414536e-09 MirTarget -0.147617738817727 0.00275611745667797 NA NA NA hsa-miR-17-5p HLF -0.097575136916686 0.206211102146113 0.569668903325758 1.16746221414536e-09 MirTarget;TargetScan;miRNATAP -0.322052657713338 3.81472006884211e-07 NA NA NA hsa-miR-186-5p HLF -0.060638189413023 0.514217717592655 0.569668903325758 1.16746221414536e-09 mirMAP -0.115500670435209 0.0144343647240066 NA NA NA hsa-miR-18a-5p HLF -0.175320895022842 0.0732549187136405 0.569668903325758 1.16746221414536e-09 MirTarget -0.153689065518631 0.000139931592296714 NA NA NA hsa-miR-196b-5p HLF -1.75082572326205 4.54452311288549e-11 0.569668903325758 1.16746221414536e-09 miRNATAP -0.118033346564028 4.39494997775213e-16 NA NA NA hsa-miR-19a-3p HLF -0.0466707843731764 0.576818938277875 0.569668903325758 1.16746221414536e-09 miRNATAP -0.249547981570758 4.42911623527792e-07 NA NA NA hsa-miR-19b-3p HLF 0.013842745084812 0.856506310672867 0.569668903325758 1.16746221414536e-09 miRNATAP -0.224277580499098 0.000152180788075533 NA NA NA hsa-miR-200c-3p HLF -0.413752622631687 8.69363337156544e-06 0.569668903325758 1.16746221414536e-09 MirTarget;miRNATAP -0.260042805256222 5.83281804793679e-10 NA NA NA hsa-miR-20a-5p HLF 0.0115865752289119 0.887069448775761 0.569668903325758 1.16746221414536e-09 MirTarget;miRNATAP -0.189812219997618 0.00118429213732767 NA NA NA hsa-miR-217 HLF -0.540279882451921 0.00312206944061315 0.569668903325758 1.16746221414536e-09 miRanda -0.117371698883769 4.31127019025355e-08 NA NA NA hsa-miR-27a-5p HLF -0.588526581446 1.44259383783548e-07 0.569668903325758 1.16746221414536e-09 MirTarget -0.239353480356772 5.29161427334422e-12 NA NA NA hsa-miR-374a-5p HLF -0.0121037060909126 0.865417963346047 0.569668903325758 1.16746221414536e-09 MirTarget;mirMAP -0.228255365365571 0.000138870885195559 NA NA NA hsa-miR-3913-5p HLF -0.276883251911602 0.00186113779811508 0.569668903325758 1.16746221414536e-09 mirMAP -0.257482933198103 5.37769737881522e-09 NA NA NA hsa-miR-500a-3p HLF -0.0479457078971821 0.494203076239348 0.569668903325758 1.16746221414536e-09 MirTarget;miRNATAP -0.151512895337911 0.0233725987375944 NA NA NA hsa-miR-500a-5p HLF -0.0634452729978798 0.396072382601725 0.569668903325758 1.16746221414536e-09 mirMAP -0.1330576864786 0.0129367656305659 NA NA NA hsa-miR-542-3p HLF -0.0835995677900652 0.403838744494172 0.569668903325758 1.16746221414536e-09 miRNATAP -0.37432454966204 1.4535489141931e-18 NA NA NA hsa-miR-590-3p HLF -0.312951515438399 0.00048045542384394 0.569668903325758 1.16746221414536e-09 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.202613067086033 4.172758845772e-06 NA NA NA hsa-miR-708-3p HLF -0.00458267260361467 0.962455132950912 0.569668903325758 1.16746221414536e-09 MirTarget -0.13991813421266 0.0021516592504972 NA NA NA hsa-miR-93-5p HLF -0.139766237971079 0.101057320076733 0.569668903325758 1.16746221414536e-09 MirTarget;miRNATAP -0.669587642144284 3.54022601703866e-22 NA NA NA hsa-miR-204-5p IGF2R 0.288588537398083 0.113371226435799 -0.179673669763197 0.00429508720839548 MirTarget -0.10886810192301 1.0081941897127e-19 NA NA NA hsa-miR-342-3p IGF2R 0.125683829770898 0.105810751640081 -0.179673669763197 0.00429508720839548 miRanda -0.132123177953702 4.66433414489719e-05 NA NA NA hsa-miR-9-5p IGF2R 0.125377971246515 0.269896477801932 -0.179673669763197 0.00429508720839548 miRNAWalker2_validate -0.239550419809163 1.07766758057877e-06 NA NA NA hsa-miR-139-5p IL6 0.647754756897662 2.1537830723695e-06 -0.860210379772633 5.71029329538115e-06 miRanda -0.193255461876079 0.00224121799463508 NA NA NA hsa-miR-181a-5p INHBA 0.178215604431884 0.0700010802254993 0.111178514068956 0.4197307386229 mirMAP -0.21980734414689 0.00906745955769609 NA NA NA hsa-miR-181b-5p INHBA -0.0260899284211344 0.768941836912778 0.111178514068956 0.4197307386229 mirMAP -0.259906696166872 0.00224256513341453 NA NA NA hsa-miR-30b-5p INHBA 0.085810101632239 0.263243418521696 0.111178514068956 0.4197307386229 mirMAP -0.269174831076884 0.00461659150305601 NA NA NA hsa-miR-30c-5p INHBA 0.0469114469943488 0.565934557464302 0.111178514068956 0.4197307386229 mirMAP -0.252109591297816 0.00826402161586394 NA NA NA hsa-miR-577 INHBA 0.382068371859265 0.0145513192729146 0.111178514068956 0.4197307386229 mirMAP -0.116630482638817 0.00271533769710923 NA NA NA hsa-miR-9-5p INHBA 0.125377971246515 0.269896477801932 0.111178514068956 0.4197307386229 mirMAP -0.495464738814837 0.000177388910911551 NA NA NA hsa-miR-142-5p KCNB1 -0.434884875454099 0.000575570345702933 0.798488218003589 5.71800426196412e-11 mirMAP -0.222615138549613 9.46748078006799e-08 NA NA NA hsa-miR-146b-5p KCNB1 -0.441078059667276 0.000237619929889549 0.798488218003589 5.71800426196412e-11 mirMAP -0.370857102142938 3.32743265771031e-16 NA NA NA hsa-miR-16-2-3p KCNB1 -0.468816222075622 7.04377763166223e-05 0.798488218003589 5.71800426196412e-11 mirMAP -0.287660771366547 7.58162121444035e-11 NA NA NA hsa-miR-17-5p KCNB1 -0.097575136916686 0.206211102146113 0.798488218003589 5.71800426196412e-11 TargetScan -0.317173455732786 0.000225172109626099 NA NA NA hsa-miR-200b-3p KCNB1 -0.24576852650451 0.0580744465744749 0.798488218003589 5.71800426196412e-11 TargetScan -0.228825136080613 3.90764380356146e-08 NA NA NA hsa-miR-2355-3p KCNB1 -0.186207523505298 0.0525918026992985 0.798488218003589 5.71800426196412e-11 mirMAP -0.238745998125095 1.56223681438395e-05 NA NA NA hsa-miR-29b-1-5p KCNB1 -0.191335428755769 0.0084643645479085 0.798488218003589 5.71800426196412e-11 mirMAP -0.152672027911796 0.0385159161883495 NA NA NA hsa-miR-320a KCNB1 -0.0921355996367019 0.243028758990046 0.798488218003589 5.71800426196412e-11 mirMAP -0.364863199836001 1.60056809874674e-05 NA NA NA hsa-miR-320b KCNB1 -0.28347774630417 0.000595376302090892 0.798488218003589 5.71800426196412e-11 mirMAP -0.245378699535279 0.000143092223792986 NA NA NA hsa-miR-320c KCNB1 -0.343259124189967 0.000248338401291042 0.798488218003589 5.71800426196412e-11 mirMAP -0.283050299711237 1.18921609268392e-06 NA NA NA hsa-miR-335-5p KCNB1 -0.0938511632756835 0.336889056387767 0.798488218003589 5.71800426196412e-11 mirMAP -0.127926982519024 0.0223495547978365 NA NA NA hsa-miR-3682-3p KCNB1 -0.113471485204648 0.266481019608971 0.798488218003589 5.71800426196412e-11 mirMAP -0.128778523675382 0.0173744714077976 NA NA NA hsa-miR-450b-5p KCNB1 -0.270544879013982 0.00801537838499814 0.798488218003589 5.71800426196412e-11 mirMAP -0.159887297756569 0.0026862310211881 NA NA NA hsa-miR-548b-3p KCNB1 -0.340474544210108 0.00224491592019744 0.798488218003589 5.71800426196412e-11 mirMAP -0.308238882291429 1.19870372873227e-10 NA NA NA hsa-miR-590-3p KCNB1 -0.312951515438399 0.00048045542384394 0.798488218003589 5.71800426196412e-11 miRanda;mirMAP -0.401814814551273 7.13003117277608e-12 NA NA NA hsa-miR-625-3p KCNB1 0.0638840950852995 0.547354471746944 0.798488218003589 5.71800426196412e-11 mirMAP -0.20734776395042 5.95851951440702e-05 NA NA NA hsa-miR-106b-5p KCNK10 -0.167096183547595 0.0497544396383733 0.046949960271117 0.716646679355152 MirTarget;miRNATAP -0.274730461537098 0.000248770309732442 NA NA NA hsa-miR-125a-5p KCNK10 0.0833349424517795 0.32544020025337 0.046949960271117 0.716646679355152 MirTarget -0.68371412863498 9.90565628508277e-18 NA NA NA hsa-miR-125b-5p KCNK10 0.0119698382910922 0.890233923196969 0.046949960271117 0.716646679355152 MirTarget;miRNATAP -0.603271931067303 5.56297075277752e-10 NA NA NA hsa-miR-1266-5p KCNK10 -0.313515127917259 0.0138664194727391 0.046949960271117 0.716646679355152 MirTarget -0.206664461226297 3.02888774988808e-06 NA NA NA hsa-miR-130a-3p KCNK10 -0.163798739071218 0.0312594912163825 0.046949960271117 0.716646679355152 miRNATAP -0.217884733937437 0.00875278574579992 NA NA NA hsa-miR-142-5p KCNK10 -0.434884875454099 0.000575570345702933 0.046949960271117 0.716646679355152 mirMAP -0.207782814263405 2.45518783201505e-06 NA NA NA hsa-miR-17-5p KCNK10 -0.097575136916686 0.206211102146113 0.046949960271117 0.716646679355152 MirTarget;TargetScan;miRNATAP -0.202914392071981 0.0257525719956856 NA NA NA hsa-miR-215-5p KCNK10 -0.545674318352698 2.3515059623745e-05 0.046949960271117 0.716646679355152 MirTarget -0.126718460588413 0.00458336071348217 NA NA NA hsa-miR-301a-3p KCNK10 -0.00956875714541239 0.916380325220387 0.046949960271117 0.716646679355152 miRNATAP -0.550873979954843 1.69463574371247e-18 NA NA NA hsa-miR-3065-5p KCNK10 0.262608140481518 0.0414570974147947 0.046949960271117 0.716646679355152 mirMAP;miRNATAP -0.36825239224351 5.42778077906387e-18 NA NA NA hsa-miR-30a-3p KCNK10 -0.0655410309550497 0.509541256242263 0.046949960271117 0.716646679355152 MirTarget;miRNATAP -0.399656759433981 5.09882095320618e-08 NA NA NA hsa-miR-30d-3p KCNK10 -0.0854049347792865 0.206912548011228 0.046949960271117 0.716646679355152 MirTarget;miRNATAP -0.428531796496704 2.90052003518562e-07 NA NA NA hsa-miR-30e-3p KCNK10 -0.00173769765871867 0.98496550154767 0.046949960271117 0.716646679355152 MirTarget -0.621484558669595 3.15517025916068e-14 NA NA NA hsa-miR-32-5p KCNK10 -0.130313603388213 0.177843055266183 0.046949960271117 0.716646679355152 MirTarget;miRNATAP -0.291277667303342 8.04972176271814e-07 NA NA NA hsa-miR-362-3p KCNK10 -0.032375035235532 0.736465332563774 0.046949960271117 0.716646679355152 miRNATAP -0.181153829142532 0.00206326595772491 NA NA NA hsa-miR-421 KCNK10 0.171573235029884 0.0518112933650958 0.046949960271117 0.716646679355152 mirMAP -0.226630830339584 0.00041017087063889 NA NA NA hsa-miR-454-3p KCNK10 -0.177318549827637 0.0120865170334474 0.046949960271117 0.716646679355152 MirTarget;miRNATAP -0.293031445112714 0.000434612138064744 NA NA NA hsa-miR-455-3p KCNK10 -0.51270181640209 0.000459755983280324 0.046949960271117 0.716646679355152 MirTarget -0.266971337852992 2.38253141875673e-12 NA NA NA hsa-miR-532-5p KCNK10 -0.0263466708636777 0.757630060399045 0.046949960271117 0.716646679355152 miRNATAP -0.378647065624112 2.38419332672075e-06 NA NA NA hsa-miR-589-3p KCNK10 -0.00739371736361327 0.927768051649327 0.046949960271117 0.716646679355152 mirMAP -0.415742065606737 1.73078568188924e-09 NA NA NA hsa-miR-590-3p KCNK10 -0.312951515438399 0.00048045542384394 0.046949960271117 0.716646679355152 mirMAP -0.320649835937755 2.74925527026045e-07 NA NA NA hsa-miR-590-5p KCNK10 -0.169460270359482 0.0386004382081766 0.046949960271117 0.716646679355152 miRanda -0.403873027424901 4.51553598592041e-09 NA NA NA hsa-miR-664a-3p KCNK10 -0.0413918462466984 0.611334357897205 0.046949960271117 0.716646679355152 mirMAP -0.148402331865112 0.0376832328865367 NA NA NA hsa-miR-92b-3p KCNK10 0.213968504162006 0.0523921855715249 0.046949960271117 0.716646679355152 MirTarget;miRNATAP -0.461667293949376 1.8779581488958e-15 NA NA NA hsa-miR-93-5p KCNK10 -0.139766237971079 0.101057320076733 0.046949960271117 0.716646679355152 MirTarget;miRNATAP -0.26586488039451 0.00937714838893306 NA NA NA hsa-let-7a-3p KLF8 -0.0530563276543585 0.370749834463726 -0.0560026047950268 0.610585582409882 mirMAP -0.253879525122758 0.00530538703551105 NA NA NA hsa-miR-3065-3p KLF8 0.261348288537912 0.0343753235107738 -0.0560026047950268 0.610585582409882 miRNATAP -0.278644791484776 3.38644517589394e-12 NA NA NA hsa-miR-3065-5p KLF8 0.262608140481518 0.0414570974147947 -0.0560026047950268 0.610585582409882 miRNATAP -0.270757489219701 1.55971920348178e-13 NA NA NA hsa-miR-320a KLF8 -0.0921355996367019 0.243028758990046 -0.0560026047950268 0.610585582409882 mirMAP -0.284043905281712 0.000192931655681584 NA NA NA hsa-miR-320c KLF8 -0.343259124189967 0.000248338401291042 -0.0560026047950268 0.610585582409882 mirMAP -0.159451359031456 0.00250069246792448 NA NA NA hsa-miR-155-5p LARP4B -0.969837380981077 5.86551495710366e-15 0.128368378047375 0.00544422324608826 mirMAP -0.105062336750657 2.01542191664841e-24 NA NA NA hsa-miR-30a-5p LARP4B 0.0629429366112948 0.513851954699872 0.128368378047375 0.00544422324608826 miRNAWalker2_validate -0.24108819538899 5.6819324863531e-27 NA NA NA hsa-miR-335-3p LARP4B -0.345405843355925 0.000438486602223359 0.128368378047375 0.00544422324608826 MirTarget -0.123925897482047 9.38717069102863e-19 NA NA NA hsa-miR-16-5p LMTK3 -0.246024668671255 0.00346042804504067 0.323913950610631 1.9684291821927e-05 miRNAWalker2_validate -0.105950523681166 0.013113442902437 NA NA NA hsa-miR-193a-5p LMTK3 -0.183172152450463 0.0749251910521666 0.323913950610631 1.9684291821927e-05 miRNATAP -0.139527041258586 4.09017747252753e-06 NA NA NA hsa-miR-30b-3p LYN 0.127948682481844 0.0864252098996909 -0.313695697836493 0.00018888839039551 MirTarget -0.111281948741623 0.021041986275834 NA NA NA hsa-let-7b-3p MARCKS 0.00495618733300152 0.95228898068683 0.10587779860699 0.190059303769629 MirTarget -0.101226943295618 0.00322211637000499 NA NA NA hsa-let-7f-1-3p MARCKS -0.110713086694052 0.214845243005185 0.10587779860699 0.190059303769629 MirTarget -0.266161165447545 1.6323774998031e-19 NA NA NA hsa-miR-126-5p MARCKS -0.177332403948646 0.0711675116243408 0.10587779860699 0.190059303769629 mirMAP -0.194696140383294 8.88066943180541e-12 NA NA NA hsa-miR-140-3p MARCKS 0.123864258867744 0.147966866194363 0.10587779860699 0.190059303769629 MirTarget;PITA;miRNATAP -0.213109975452998 3.44551406246878e-07 NA NA NA hsa-miR-142-3p MARCKS -0.558908907203953 1.37828834702525e-05 0.10587779860699 0.190059303769629 MirTarget;PITA;miRanda;miRNATAP -0.218897388413682 5.19401423103548e-26 NA NA NA hsa-miR-144-5p MARCKS -0.0784834905249356 0.620720209395369 0.10587779860699 0.190059303769629 MirTarget -0.103650853633445 1.76844163298226e-09 NA NA NA hsa-miR-145-5p MARCKS -0.108948399942988 0.310032352776812 0.10587779860699 0.190059303769629 MirTarget -0.221878623102225 1.75142723360888e-17 NA NA NA hsa-miR-155-5p MARCKS -0.969837380981077 5.86551495710366e-15 0.10587779860699 0.190059303769629 miRNAWalker2_validate -0.235083558285465 1.56918463575095e-31 NA NA NA hsa-miR-15b-5p MARCKS -0.59286315669281 1.41971517354318e-10 0.10587779860699 0.190059303769629 miRNAWalker2_validate -0.228680298089243 3.97906952104844e-14 NA NA NA hsa-miR-16-1-3p MARCKS -0.346674816118499 1.8644785016764e-05 0.10587779860699 0.190059303769629 MirTarget -0.217441018712923 6.36177689914953e-11 NA NA NA hsa-miR-199a-5p MARCKS -0.174889610847956 0.0900027418912677 0.10587779860699 0.190059303769629 miRanda -0.221920433141698 1.28162644096424e-17 NA NA NA hsa-miR-200b-3p MARCKS -0.24576852650451 0.0580744465744749 0.10587779860699 0.190059303769629 MirTarget;TargetScan -0.250722179069945 3.70239957417917e-36 NA NA NA hsa-miR-200c-3p MARCKS -0.413752622631687 8.69363337156544e-06 0.10587779860699 0.190059303769629 MirTarget -0.277599275187056 3.43667970230837e-23 20957176 Functional target identification studies suggest that the morphological effects of miR-200c may be mediated by reduced expression of MARCKS which has been linked to formation of cell protrusions melanoma hsa-miR-21-5p MARCKS -1.05049251753105 2.58081295984588e-11 0.10587779860699 0.190059303769629 miRNAWalker2_validate;miRTarBase -0.143908434517577 3.43031120392992e-14 19302977 MicroRNA 21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells drug resistance prostate cancer hsa-miR-218-5p MARCKS 0.534287404275844 0.00308322441944715 0.10587779860699 0.190059303769629 MirTarget -0.120245958466851 1.32350331357634e-16 NA NA NA hsa-miR-23a-3p MARCKS -0.334693010651073 0.00144448147063592 0.10587779860699 0.190059303769629 MirTarget -0.304119629371044 2.12965828910083e-27 NA NA NA hsa-miR-23b-3p MARCKS -0.0476610245859863 0.630277683372509 0.10587779860699 0.190059303769629 MirTarget -0.374193118466772 3.97679454683986e-39 24985346 Among various microRNAs miRNAs increased in BM-MSC-derived exosomes compared with those from adult fibroblasts overexpression of miR-23b in BM2 cells induced dormant phenotypes through the suppression of a target gene MARCKS which encodes a protein that promotes cell cycling and motility; Metastatic breast cancer cells in patient bone marrow had increased miR-23b and decreased MARCKS expression motility breast cancer hsa-miR-27a-3p MARCKS -0.30376003289577 0.00457375391190104 0.10587779860699 0.190059303769629 MirTarget -0.260016387141825 6.36775869258068e-23 NA NA NA hsa-miR-27b-3p MARCKS 0.0599187745243448 0.582081434759731 0.10587779860699 0.190059303769629 MirTarget -0.297319606180948 6.13400262540765e-30 NA NA NA hsa-miR-299-5p MARCKS 0.0814737109317376 0.576202442267832 0.10587779860699 0.190059303769629 miRNATAP -0.140689503913794 2.66021962775712e-14 NA NA NA hsa-miR-323b-3p MARCKS 0.254474308066902 0.156513296337192 0.10587779860699 0.190059303769629 MirTarget -0.102317913550453 6.40729559083635e-12 NA NA NA hsa-miR-338-3p MARCKS 0.399637046793888 0.00344106432206527 0.10587779860699 0.190059303769629 miRanda -0.100896638419028 3.44587009301605e-06 NA NA NA hsa-miR-33a-3p MARCKS 0.15836637661919 0.0991512910387245 0.10587779860699 0.190059303769629 mirMAP -0.14356883319327 3.84232723936613e-07 NA NA NA hsa-miR-340-5p MARCKS 0.110504550202752 0.205224261934695 0.10587779860699 0.190059303769629 mirMAP -0.137709333750744 3.31303511330436e-05 NA NA NA hsa-miR-342-3p MARCKS 0.125683829770898 0.105810751640081 0.10587779860699 0.190059303769629 miRanda -0.26498398358359 7.07529367176442e-12 NA NA NA hsa-miR-34a-5p MARCKS -0.143472919835505 0.211283228567119 0.10587779860699 0.190059303769629 MirTarget -0.289372641095238 2.2392604244987e-37 NA NA NA hsa-miR-34c-5p MARCKS -0.181931113688087 0.257266965617378 0.10587779860699 0.190059303769629 MirTarget;PITA;miRanda -0.13563667132186 9.54237442067528e-17 26722462 miR 34c 3p inhibits cell proliferation migration and invasion of hepatocellular carcinoma by targeting MARCKS liver cancer hsa-miR-3613-5p MARCKS -0.290347525750067 0.000408393430033661 0.10587779860699 0.190059303769629 miRNATAP -0.152992556861919 4.24390121331079e-06 NA NA NA hsa-miR-409-5p MARCKS 0.116083147809539 0.438899008482793 0.10587779860699 0.190059303769629 MirTarget;PITA -0.121544022812343 1.16373394139082e-11 NA NA NA hsa-miR-491-3p MARCKS 0.523374665885355 1.93479565404968e-05 0.10587779860699 0.190059303769629 MirTarget;PITA -0.186660849021778 2.79754851944521e-18 NA NA NA hsa-miR-491-5p MARCKS 0.749881113074991 8.22859263178918e-09 0.10587779860699 0.190059303769629 MirTarget;miRanda;miRNATAP -0.142941856501975 1.15259478027401e-12 NA NA NA hsa-miR-495-3p MARCKS 0.421982588962492 0.00504424038527033 0.10587779860699 0.190059303769629 MirTarget -0.126184286268379 1.22754152471512e-12 NA NA NA hsa-miR-501-3p MARCKS -0.0726267165568473 0.382729320534965 0.10587779860699 0.190059303769629 PITA;TargetScan -0.261408425086175 3.96668970988402e-15 NA NA NA hsa-miR-502-3p MARCKS -0.0276791089364163 0.69760501136877 0.10587779860699 0.190059303769629 PITA -0.309659152805726 2.90476815350351e-16 NA NA NA hsa-miR-543 MARCKS 0.347737549779626 0.0157394585079679 0.10587779860699 0.190059303769629 miRanda -0.15306455137422 3.80311433108286e-16 NA NA NA hsa-miR-548b-3p MARCKS -0.340474544210108 0.00224491592019744 0.10587779860699 0.190059303769629 MirTarget -0.175342891521373 4.55190430260167e-13 NA NA NA hsa-miR-576-5p MARCKS -0.106482276040039 0.194379152564202 0.10587779860699 0.190059303769629 mirMAP -0.261856047645274 1.46093236334021e-15 NA NA NA hsa-miR-582-3p MARCKS 0.118075891830139 0.304077332003561 0.10587779860699 0.190059303769629 PITA -0.11753361248962 1.1033975958707e-06 NA NA NA hsa-miR-590-3p MARCKS -0.312951515438399 0.00048045542384394 0.10587779860699 0.190059303769629 miRanda;mirMAP -0.252349496278733 1.04946430257494e-17 NA NA NA hsa-miR-628-3p MARCKS 0.243661425878071 0.059475849627908 0.10587779860699 0.190059303769629 MirTarget -0.183223742204437 8.13774223223774e-19 NA NA NA hsa-miR-655-3p MARCKS 0.241086974063522 0.0960363954844231 0.10587779860699 0.190059303769629 MirTarget -0.140612301853847 2.42245619199993e-14 NA NA NA hsa-miR-7-1-3p MARCKS 0.0894475316162513 0.373223597851017 0.10587779860699 0.190059303769629 mirMAP -0.294517530623806 3.99529354689131e-30 NA NA NA hsa-miR-769-3p MARCKS 0.287263649023215 0.0181452243308445 0.10587779860699 0.190059303769629 MirTarget;PITA;miRNATAP -0.231742770707674 1.10113606085612e-27 NA NA NA hsa-miR-877-5p MARCKS 0.0775421790642759 0.423413623033694 0.10587779860699 0.190059303769629 miRNAWalker2_validate -0.227592657142724 8.67026065279999e-17 NA NA NA hsa-miR-885-5p MARCKS 0.423614695846888 1.14213289528296e-05 0.10587779860699 0.190059303769629 MirTarget;PITA -0.19327490050506 8.66713782210718e-12 NA NA NA hsa-miR-19b-3p MEF2C 0.013842745084812 0.856506310672867 0.166420430523062 0.0845020128897449 miRNATAP -0.146031523239937 0.0149721120953118 NA NA NA hsa-miR-320a MEF2C -0.0921355996367019 0.243028758990046 0.166420430523062 0.0845020128897449 miRanda -0.346422128394759 3.81079802316126e-08 NA NA NA hsa-miR-9-5p MEF2C 0.125377971246515 0.269896477801932 0.166420430523062 0.0845020128897449 MirTarget;miRNATAP -0.317028058516429 0.000307074492071552 NA NA NA hsa-miR-30c-5p MTDH 0.0469114469943488 0.565934557464302 -0.035315749400552 0.452761791886252 miRNAWalker2_validate;miRNATAP -0.102997143539355 4.30345667811569e-07 NA NA NA hsa-miR-9-3p MTDH 0.184945845984739 0.0290051908008628 -0.035315749400552 0.452761791886252 miRNATAP -0.112446326061122 5.40504150638537e-08 NA NA NA hsa-miR-107 NCAM1 0.121070851008406 0.19838128189417 0.227850665758579 0.00678873823854343 miRanda -0.130115750459218 3.18177318981412e-05 NA NA NA hsa-miR-141-3p NCAM1 -0.411205619919922 0.000393344390969032 0.227850665758579 0.00678873823854343 TargetScan -0.180864690380844 3.51489804205622e-14 NA NA NA hsa-miR-142-3p NCAM1 -0.558908907203953 1.37828834702525e-05 0.227850665758579 0.00678873823854343 miRanda -0.16990205286137 5.48678720307447e-15 NA NA NA hsa-miR-148a-3p NCAM1 -0.30682159249341 0.039235695888613 0.227850665758579 0.00678873823854343 miRNATAP -0.245282090088401 2.75914137229078e-41 NA NA NA hsa-miR-148b-3p NCAM1 -0.0710353380371309 0.322794068460372 0.227850665758579 0.00678873823854343 miRNATAP -0.336166434304435 1.55647187781057e-14 NA NA NA hsa-miR-186-5p NCAM1 -0.060638189413023 0.514217717592655 0.227850665758579 0.00678873823854343 MirTarget;mirMAP -0.231086022994044 1.04811917633269e-12 NA NA NA hsa-miR-193a-3p NCAM1 -0.395602305834739 0.00182611787714301 0.227850665758579 0.00678873823854343 miRanda -0.20323853440892 4.57200795462887e-21 NA NA NA hsa-miR-197-3p NCAM1 0.176796295244346 0.0837698554788909 0.227850665758579 0.00678873823854343 miRNATAP -0.126157328267093 4.58293264103749e-05 NA NA NA hsa-miR-200b-3p NCAM1 -0.24576852650451 0.0580744465744749 0.227850665758579 0.00678873823854343 TargetScan -0.146654554130768 9.32103682658864e-12 NA NA NA hsa-miR-200c-3p NCAM1 -0.413752622631687 8.69363337156544e-06 0.227850665758579 0.00678873823854343 miRTarBase -0.240871609892103 1.08724112851456e-16 NA NA NA hsa-miR-204-5p NCAM1 0.288588537398083 0.113371226435799 0.227850665758579 0.00678873823854343 mirMAP;miRNATAP -0.139571479545875 3.36578784776737e-21 NA NA NA hsa-miR-21-3p NCAM1 -1.34842839438219 2.00360222274149e-17 0.227850665758579 0.00678873823854343 MirTarget -0.146321374026021 2.48610893102514e-18 NA NA NA hsa-miR-210-3p NCAM1 -0.355010738533682 0.00240748178514289 0.227850665758579 0.00678873823854343 miRNAWalker2_validate;miRTarBase -0.16109564449274 3.26074191778487e-11 NA NA NA hsa-miR-23a-3p NCAM1 -0.334693010651073 0.00144448147063592 0.227850665758579 0.00678873823854343 mirMAP -0.219268915458511 1.16440460723738e-13 NA NA NA hsa-miR-23b-3p NCAM1 -0.0476610245859863 0.630277683372509 0.227850665758579 0.00678873823854343 mirMAP -0.143536063722833 4.76570047741033e-06 NA NA NA hsa-miR-26a-2-3p NCAM1 -0.265975016486082 0.000796444054340058 0.227850665758579 0.00678873823854343 mirMAP -0.187858235957752 6.87495206661288e-08 NA NA NA hsa-miR-27a-3p NCAM1 -0.30376003289577 0.00457375391190104 0.227850665758579 0.00678873823854343 miRNATAP -0.18983245584761 6.4290382254205e-12 NA NA NA hsa-miR-27b-3p NCAM1 0.0599187745243448 0.582081434759731 0.227850665758579 0.00678873823854343 miRNATAP -0.107558333726419 0.000139863767932174 NA NA NA hsa-miR-28-3p NCAM1 -0.139444423970973 0.0811187936165283 0.227850665758579 0.00678873823854343 miRNATAP -0.284955920811117 1.58049705666665e-10 NA NA NA hsa-miR-28-5p NCAM1 -0.104003572105765 0.153594705579597 0.227850665758579 0.00678873823854343 PITA;miRanda -0.187459840900404 4.89858408122981e-06 NA NA NA hsa-miR-29a-5p NCAM1 0.0697727833812762 0.350621682973061 0.227850665758579 0.00678873823854343 mirMAP -0.113487920190066 0.00290309004378275 NA NA NA hsa-miR-29b-2-5p NCAM1 0.268342619557287 0.00453760540519983 0.227850665758579 0.00678873823854343 mirMAP -0.187479067006503 2.50725322857851e-10 NA NA NA hsa-miR-30a-5p NCAM1 0.0629429366112948 0.513851954699872 0.227850665758579 0.00678873823854343 MirTarget;miRNATAP -0.340980754687443 3.32669227548441e-13 NA NA NA hsa-miR-30b-5p NCAM1 0.085810101632239 0.263243418521696 0.227850665758579 0.00678873823854343 MirTarget;miRNATAP -0.136214705217393 0.00189320252688099 NA NA NA hsa-miR-30c-5p NCAM1 0.0469114469943488 0.565934557464302 0.227850665758579 0.00678873823854343 MirTarget;miRNATAP -0.378180038356269 7.04093893613342e-19 NA NA NA hsa-miR-30d-5p NCAM1 0.0607010868720561 0.471410043548418 0.227850665758579 0.00678873823854343 MirTarget;miRNATAP -0.148025381372683 0.00320121275414958 NA NA NA hsa-miR-30e-5p NCAM1 -0.0764521828640508 0.419049916296479 0.227850665758579 0.00678873823854343 MirTarget;miRNATAP -0.292946849695332 6.35221151160798e-13 NA NA NA hsa-miR-335-3p NCAM1 -0.345405843355925 0.000438486602223359 0.227850665758579 0.00678873823854343 mirMAP -0.116103162844437 7.36251022999538e-05 NA NA NA hsa-miR-34c-5p NCAM1 -0.181931113688087 0.257266965617378 0.227850665758579 0.00678873823854343 miRanda -0.134848256366699 7.80342190856563e-16 NA NA NA hsa-miR-361-3p NCAM1 0.0798653643614768 0.271064714084425 0.227850665758579 0.00678873823854343 PITA -0.239378145988898 4.13578136476739e-08 NA NA NA hsa-miR-362-3p NCAM1 -0.032375035235532 0.736465332563774 0.227850665758579 0.00678873823854343 miRanda -0.151088532763451 1.54579024655108e-07 NA NA NA hsa-miR-375 NCAM1 0.0268401141324208 0.858358101444604 0.227850665758579 0.00678873823854343 miRNAWalker2_validate;miRanda -0.107276433570675 3.8618741176586e-09 NA NA NA hsa-miR-425-5p NCAM1 0.0412837711174845 0.682284485592652 0.227850665758579 0.00678873823854343 miRNATAP -0.170485118378281 4.00848998759189e-09 NA NA NA hsa-miR-550a-5p NCAM1 -0.44674257664177 3.20431264038783e-06 0.227850665758579 0.00678873823854343 MirTarget -0.125255180441083 1.31244470359386e-05 NA NA NA hsa-miR-576-5p NCAM1 -0.106482276040039 0.194379152564202 0.227850665758579 0.00678873823854343 mirMAP -0.240456775627846 1.1061138685497e-12 NA NA NA hsa-miR-590-3p NCAM1 -0.312951515438399 0.00048045542384394 0.227850665758579 0.00678873823854343 miRanda -0.197012486581767 1.20208187646248e-10 NA NA NA hsa-miR-590-5p NCAM1 -0.169460270359482 0.0386004382081766 0.227850665758579 0.00678873823854343 miRanda -0.190102837506319 2.41151928883044e-08 NA NA NA hsa-miR-629-5p NCAM1 -0.100422082714453 0.214291160007633 0.227850665758579 0.00678873823854343 MirTarget -0.138300563013153 0.000220306868368946 NA NA NA hsa-miR-7-1-3p NCAM1 0.0894475316162513 0.373223597851017 0.227850665758579 0.00678873823854343 mirMAP -0.118619932686179 2.04717232000881e-05 NA NA NA hsa-miR-9-5p NEK9 0.125377971246515 0.269896477801932 -0.0267147344537495 0.64219416076068 MirTarget -0.135497554970185 0.00249245022297125 NA NA NA hsa-miR-1262 OPCML -0.276259331706731 0.0259799942226561 0.539237752767841 3.30055496515861e-05 mirMAP -0.264262505058274 4.47402666120622e-09 NA NA NA hsa-miR-15b-3p OPCML -0.690804403863834 8.4878475512421e-09 0.539237752767841 3.30055496515861e-05 mirMAP -0.182116035677379 5.8333437088386e-05 NA NA NA hsa-miR-196b-5p OPCML -1.75082572326205 4.54452311288549e-11 0.539237752767841 3.30055496515861e-05 miRNATAP -0.129314914258397 3.19839062582833e-10 NA NA NA hsa-miR-20a-3p OPCML -0.102743778777987 0.196778653597552 0.539237752767841 3.30055496515861e-05 mirMAP -0.146617067373245 0.0385422591920654 NA NA NA hsa-miR-217 OPCML -0.540279882451921 0.00312206944061315 0.539237752767841 3.30055496515861e-05 miRanda -0.112319149832214 0.000199213342131697 NA NA NA hsa-miR-23a-3p OPCML -0.334693010651073 0.00144448147063592 0.539237752767841 3.30055496515861e-05 mirMAP -0.461501096061466 3.75325450973928e-15 NA NA NA hsa-miR-25-3p OPCML -0.316649850160946 0.000777982468388745 0.539237752767841 3.30055496515861e-05 mirMAP -0.428231653705782 1.99595474330401e-08 NA NA NA hsa-miR-26b-5p OPCML 0.0984536538763106 0.231803769574464 0.539237752767841 3.30055496515861e-05 mirMAP -0.27158103431243 0.000772006622168872 NA NA NA hsa-miR-301a-3p OPCML -0.00956875714541239 0.916380325220387 0.539237752767841 3.30055496515861e-05 mirMAP -0.159237169730016 0.0126759021654192 NA NA NA hsa-miR-32-5p OPCML -0.130313603388213 0.177843055266183 0.539237752767841 3.30055496515861e-05 mirMAP -0.172762784176831 0.00316436013226471 NA NA NA hsa-miR-362-3p OPCML -0.032375035235532 0.736465332563774 0.539237752767841 3.30055496515861e-05 MirTarget;PITA;miRanda;miRNATAP -0.159945009888827 0.0057577488376978 NA NA NA hsa-miR-362-5p OPCML 0.0730185557229386 0.425572997292157 0.539237752767841 3.30055496515861e-05 mirMAP -0.138155944738897 0.0255542751652884 NA NA NA hsa-miR-3622a-3p OPCML -0.0389203848593475 0.756058129624588 0.539237752767841 3.30055496515861e-05 miRNATAP -0.101499109411544 0.0251508124779825 NA NA NA hsa-miR-454-3p OPCML -0.177318549827637 0.0120865170334474 0.539237752767841 3.30055496515861e-05 mirMAP -0.219483839093323 0.00757300096725259 NA NA NA hsa-miR-455-5p OPCML -0.332224239762001 0.0106491358056235 0.539237752767841 3.30055496515861e-05 miRanda -0.107438558094367 0.0119811361506698 NA NA NA hsa-miR-501-5p OPCML -0.0878951859817464 0.309663377222435 0.539237752767841 3.30055496515861e-05 mirMAP -0.242720921845161 0.000163048402924612 NA NA NA hsa-miR-532-5p OPCML -0.0263466708636777 0.757630060399045 0.539237752767841 3.30055496515861e-05 mirMAP -0.27481976032749 0.000536339478596242 NA NA NA hsa-miR-590-3p OPCML -0.312951515438399 0.00048045542384394 0.539237752767841 3.30055496515861e-05 mirMAP -0.402063827322683 4.07982217941362e-11 NA NA NA hsa-miR-590-5p OPCML -0.169460270359482 0.0386004382081766 0.539237752767841 3.30055496515861e-05 mirMAP -0.356660361137426 1.56936155213672e-07 NA NA NA hsa-miR-92b-3p OPCML 0.213968504162006 0.0523921855715249 0.539237752767841 3.30055496515861e-05 mirMAP -0.214122534537086 0.000253443208322428 NA NA NA hsa-miR-942-5p OPCML -0.331570745524138 0.00475398014468333 0.539237752767841 3.30055496515861e-05 MirTarget -0.165475323337111 0.00053533489372157 NA NA NA hsa-let-7a-2-3p PDGFRA -0.295235553592456 0.00290654476250626 0.214227835759105 0.123422750860141 MirTarget -0.296334233533416 4.11922197722786e-07 NA NA NA hsa-let-7b-3p PDGFRA 0.00495618733300152 0.95228898068683 0.214227835759105 0.123422750860141 mirMAP -0.152323940859008 0.0367319843105741 NA NA NA hsa-let-7f-1-3p PDGFRA -0.110713086694052 0.214845243005185 0.214227835759105 0.123422750860141 mirMAP -0.239111230215239 0.000205273554105078 NA NA NA hsa-miR-106a-5p PDGFRA -0.110074064773885 0.130458159906254 0.214227835759105 0.123422750860141 MirTarget;miRNATAP -0.291101709809366 0.000522324338760065 NA NA NA hsa-miR-125a-3p PDGFRA -0.183834985432375 0.106230647107919 0.214227835759105 0.123422750860141 miRanda -0.218704614786785 1.83272444389053e-05 NA NA NA hsa-miR-125a-5p PDGFRA 0.0833349424517795 0.32544020025337 0.214227835759105 0.123422750860141 miRanda -0.584043237308749 1.35379706476998e-12 NA NA NA hsa-miR-132-3p PDGFRA 0.178379362833879 0.133352008771241 0.214227835759105 0.123422750860141 miRNATAP -0.187831850273597 0.000250319391344747 NA NA NA hsa-miR-141-3p PDGFRA -0.411205619919922 0.000393344390969032 0.214227835759105 0.123422750860141 MirTarget -0.212944157891481 2.31787320191516e-05 NA NA NA hsa-miR-142-5p PDGFRA -0.434884875454099 0.000575570345702933 0.214227835759105 0.123422750860141 PITA;mirMAP;miRNATAP -0.255106354672294 1.29328581244106e-08 NA NA NA hsa-miR-143-3p PDGFRA -0.289829963197635 0.0420892105534743 0.214227835759105 0.123422750860141 miRNATAP -0.188499057787187 3.61701378371554e-05 NA NA NA hsa-miR-146b-5p PDGFRA -0.441078059667276 0.000237619929889549 0.214227835759105 0.123422750860141 miRanda -0.439250339471549 1.63797229980143e-19 NA NA NA hsa-miR-149-5p PDGFRA 0.0535821592030219 0.65771389201239 0.214227835759105 0.123422750860141 MirTarget;miRNATAP -0.251126677334923 2.0149615804524e-07 NA NA NA hsa-miR-16-1-3p PDGFRA -0.346674816118499 1.8644785016764e-05 0.214227835759105 0.123422750860141 MirTarget -0.225776587776573 0.0016066501712407 NA NA NA hsa-miR-184 PDGFRA 0.842534984406582 6.08844932017186e-08 0.214227835759105 0.123422750860141 miRanda -0.153784899830709 2.69381514856598e-05 NA NA NA hsa-miR-186-5p PDGFRA -0.060638189413023 0.514217717592655 0.214227835759105 0.123422750860141 MirTarget -0.297882320589264 1.23111767407722e-05 NA NA NA hsa-miR-193a-3p PDGFRA -0.395602305834739 0.00182611787714301 0.214227835759105 0.123422750860141 miRanda -0.273002234423519 2.46644840364766e-09 NA NA NA hsa-miR-199a-3p PDGFRA -0.412263318710744 0.000497136154474781 0.214227835759105 0.123422750860141 MirTarget;PITA;miRNATAP -0.270733214461539 2.93296438648829e-08 NA NA NA hsa-miR-199a-5p PDGFRA -0.174889610847956 0.0900027418912677 0.214227835759105 0.123422750860141 miRanda -0.26790376826415 1.965281983763e-06 NA NA NA hsa-miR-199b-3p PDGFRA -0.411848361704378 0.000517815011892612 0.214227835759105 0.123422750860141 MirTarget;PITA;miRNATAP -0.269173280120204 3.28792716796774e-08 NA NA NA hsa-miR-199b-5p PDGFRA -0.436298593972863 0.00200225454383867 0.214227835759105 0.123422750860141 miRanda -0.181040865656848 7.35837504952751e-06 NA NA NA hsa-miR-20b-5p PDGFRA -0.144541062989457 0.099204233355698 0.214227835759105 0.123422750860141 MirTarget;miRNATAP -0.280949056106333 7.10780599325753e-05 NA NA NA hsa-miR-212-3p PDGFRA 0.0141129412093419 0.918360379513015 0.214227835759105 0.123422750860141 miRNATAP -0.165210568743679 7.56823088897284e-05 NA NA NA hsa-miR-24-3p PDGFRA -0.133257261462843 0.212960921400951 0.214227835759105 0.123422750860141 MirTarget;miRNATAP -0.258693453202796 1.426608452579e-05 NA NA NA hsa-miR-26a-5p PDGFRA -0.033823776747262 0.726610414342617 0.214227835759105 0.123422750860141 MirTarget;mirMAP;miRNATAP -0.337817549965926 2.64891798560313e-06 NA NA NA hsa-miR-26b-5p PDGFRA 0.0984536538763106 0.231803769574464 0.214227835759105 0.123422750860141 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.330492068006605 7.86276476912204e-05 NA NA NA hsa-miR-27a-3p PDGFRA -0.30376003289577 0.00457375391190104 0.214227835759105 0.123422750860141 MirTarget;miRNATAP -0.332717954435526 7.42608425988857e-09 NA NA NA hsa-miR-27b-3p PDGFRA 0.0599187745243448 0.582081434759731 0.214227835759105 0.123422750860141 MirTarget;miRNATAP -0.312048975764859 7.61491715727402e-08 NA NA NA hsa-miR-28-5p PDGFRA -0.104003572105765 0.153594705579597 0.214227835759105 0.123422750860141 miRanda -0.408002281031611 1.50274553396473e-06 NA NA NA hsa-miR-29a-3p PDGFRA 0.224140851576131 0.0349516103549852 0.214227835759105 0.123422750860141 MirTarget -0.433860748502012 5.47540666642455e-10 NA NA NA hsa-miR-29b-1-5p PDGFRA -0.191335428755769 0.0084643645479085 0.214227835759105 0.123422750860141 mirMAP -0.444219655383209 1.48743564059219e-08 NA NA NA hsa-miR-29b-2-5p PDGFRA 0.268342619557287 0.00453760540519983 0.214227835759105 0.123422750860141 mirMAP -0.403170180391648 4.54797630182334e-11 NA NA NA hsa-miR-29b-3p PDGFRA 0.178522712044526 0.0856106432164969 0.214227835759105 0.123422750860141 MirTarget -0.479354783825126 2.78031130409556e-15 NA NA NA hsa-miR-29c-3p PDGFRA 0.37218039038731 0.00202634431972923 0.214227835759105 0.123422750860141 MirTarget -0.325784473603734 3.2768258385201e-10 NA NA NA hsa-miR-320b PDGFRA -0.28347774630417 0.000595376302090892 0.214227835759105 0.123422750860141 miRanda -0.162128647034815 0.0202229439185375 NA NA NA hsa-miR-320c PDGFRA -0.343259124189967 0.000248338401291042 0.214227835759105 0.123422750860141 miRanda -0.25132609270931 6.63976805483441e-05 NA NA NA hsa-miR-330-5p PDGFRA 0.262932095995619 0.0465226565966542 0.214227835759105 0.123422750860141 miRanda -0.122999029913756 0.00489006932093651 NA NA NA hsa-miR-335-3p PDGFRA -0.345405843355925 0.000438486602223359 0.214227835759105 0.123422750860141 mirMAP -0.296573735389458 8.96271541553145e-07 NA NA NA hsa-miR-339-5p PDGFRA -0.273253751377135 0.0185300170790711 0.214227835759105 0.123422750860141 miRanda -0.331337860958994 1.16346191528288e-11 NA NA NA hsa-miR-34a-5p PDGFRA -0.143472919835505 0.211283228567119 0.214227835759105 0.123422750860141 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.507657602010947 6.25800263585505e-25 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-34c-5p PDGFRA -0.181931113688087 0.257266965617378 0.214227835759105 0.123422750860141 MirTarget;PITA;miRanda;miRNATAP -0.238616457279072 8.42235088990927e-12 NA NA NA hsa-miR-362-3p PDGFRA -0.032375035235532 0.736465332563774 0.214227835759105 0.123422750860141 miRanda -0.25592920204664 1.90006109239814e-05 NA NA NA hsa-miR-455-5p PDGFRA -0.332224239762001 0.0106491358056235 0.214227835759105 0.123422750860141 MirTarget;PITA;miRanda -0.206982425909943 2.64647669398927e-06 NA NA NA hsa-miR-488-3p PDGFRA 0.257955761012583 0.00280795162806105 0.214227835759105 0.123422750860141 mirMAP -0.245006697838914 0.000325177624269067 NA NA NA hsa-miR-576-5p PDGFRA -0.106482276040039 0.194379152564202 0.214227835759105 0.123422750860141 mirMAP -0.275734374551186 0.000105383234164016 NA NA NA hsa-miR-590-3p PDGFRA -0.312951515438399 0.00048045542384394 0.214227835759105 0.123422750860141 miRanda;mirMAP -0.360558237867372 1.42959874478908e-08 NA NA NA hsa-miR-590-5p PDGFRA -0.169460270359482 0.0386004382081766 0.214227835759105 0.123422750860141 miRanda -0.339783423553957 1.57951301556451e-06 NA NA NA hsa-miR-664a-3p PDGFRA -0.0413918462466984 0.611334357897205 0.214227835759105 0.123422750860141 mirMAP -0.68336198484181 1.47148431801351e-22 NA NA NA hsa-miR-7-1-3p PDGFRA 0.0894475316162513 0.373223597851017 0.214227835759105 0.123422750860141 mirMAP -0.241177783617488 2.86345919927891e-05 NA NA NA hsa-miR-23a-3p PKP4 -0.334693010651073 0.00144448147063592 0.213427855433845 0.00153743232322154 miRNATAP -0.119492479028522 1.0323270409698e-05 NA NA NA hsa-miR-320c PKP4 -0.343259124189967 0.000248338401291042 0.213427855433845 0.00153743232322154 mirMAP -0.100622978888564 0.000251479468948482 NA NA NA hsa-miR-106a-5p PPARA -0.110074064773885 0.130458159906254 0.335389759038066 2.96327925124771e-07 miRNATAP -0.110853905431751 0.00285533096818764 NA NA NA hsa-miR-106b-5p PPARA -0.167096183547595 0.0497544396383733 0.335389759038066 2.96327925124771e-07 miRNATAP -0.120088609450472 0.000397973975705493 NA NA NA hsa-miR-146a-5p PPARA -0.148942451196266 0.114229072828761 0.335389759038066 2.96327925124771e-07 mirMAP -0.1137634459136 3.06840744170692e-05 NA NA NA hsa-miR-146b-5p PPARA -0.441078059667276 0.000237619929889549 0.335389759038066 2.96327925124771e-07 mirMAP -0.154267010592929 1.54545196570068e-12 NA NA NA hsa-miR-155-5p PPARA -0.969837380981077 5.86551495710366e-15 0.335389759038066 2.96327925124771e-07 mirMAP -0.116262420189128 4.00257760337098e-09 NA NA NA hsa-miR-17-5p PPARA -0.097575136916686 0.206211102146113 0.335389759038066 2.96327925124771e-07 TargetScan;miRNATAP -0.179772945543628 1.07802641616158e-05 NA NA NA hsa-miR-181b-5p PPARA -0.0260899284211344 0.768941836912778 0.335389759038066 2.96327925124771e-07 miRNATAP -0.156465293961218 1.21957708384917e-05 NA NA NA hsa-miR-18a-5p PPARA -0.175320895022842 0.0732549187136405 0.335389759038066 2.96327925124771e-07 mirMAP -0.134797281553192 1.66262897905316e-07 NA NA NA hsa-miR-19a-3p PPARA -0.0466707843731764 0.576818938277875 0.335389759038066 2.96327925124771e-07 MirTarget;miRNATAP -0.19013569977597 1.72188180948986e-09 NA NA NA hsa-miR-19b-1-5p PPARA -0.0686579042235513 0.332645627997482 0.335389759038066 2.96327925124771e-07 mirMAP -0.145375865200846 6.92229313518257e-05 NA NA NA hsa-miR-19b-3p PPARA 0.013842745084812 0.856506310672867 0.335389759038066 2.96327925124771e-07 MirTarget;miRNATAP -0.222011992598548 3.73656731632647e-09 NA NA NA hsa-miR-200c-3p PPARA -0.413752622631687 8.69363337156544e-06 0.335389759038066 2.96327925124771e-07 MirTarget -0.104843900610922 0.000119858225727131 NA NA NA hsa-miR-20a-5p PPARA 0.0115865752289119 0.887069448775761 0.335389759038066 2.96327925124771e-07 miRNATAP -0.203104062256415 4.95503032334125e-08 NA NA NA hsa-miR-21-3p PPARA -1.34842839438219 2.00360222274149e-17 0.335389759038066 2.96327925124771e-07 mirMAP -0.106860249331315 6.17473894560535e-12 22244963 In the final integrative analysis of lung cancer related miR-21-targets analysis 24 hub genes were identified by overlap calculation suggesting that miR-21 may play an important role in the development and progression of lung cancer through JAK/STAT signal pathway MAPK signaling pathway Wnt signaling pathway cell cycle PPAR signaling pathway apoptosis pathway and other pathways progression lung cancer hsa-miR-21-5p PPARA -1.05049251753105 2.58081295984588e-11 0.335389759038066 2.96327925124771e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.11018993610431 8.20918004042089e-10 22244963 In the final integrative analysis of lung cancer related miR-21-targets analysis 24 hub genes were identified by overlap calculation suggesting that miR-21 may play an important role in the development and progression of lung cancer through JAK/STAT signal pathway MAPK signaling pathway Wnt signaling pathway cell cycle PPAR signaling pathway apoptosis pathway and other pathways progression lung cancer hsa-miR-25-3p PPARA -0.316649850160946 0.000777982468388745 0.335389759038066 2.96327925124771e-07 mirMAP -0.169882159362935 1.36778169537478e-06 NA NA NA hsa-miR-335-3p PPARA -0.345405843355925 0.000438486602223359 0.335389759038066 2.96327925124771e-07 mirMAP -0.133668981869589 5.44666372671873e-07 NA NA NA hsa-miR-450b-5p PPARA -0.270544879013982 0.00801537838499814 0.335389759038066 2.96327925124771e-07 mirMAP -0.1025155765785 5.03674201042396e-05 NA NA NA hsa-miR-592 PPARA -0.0170005651576393 0.876633091134892 0.335389759038066 2.96327925124771e-07 mirMAP -0.155032283989318 1.41095671954321e-11 NA NA NA hsa-miR-671-5p PPARA -0.379677704170738 0.000129391032677447 0.335389759038066 2.96327925124771e-07 mirMAP -0.124564070083576 8.43790280338031e-07 NA NA NA hsa-miR-92a-1-5p PPARA -0.32438915788874 0.0012604129214261 0.335389759038066 2.96327925124771e-07 mirMAP -0.199451552607726 3.08819066370468e-15 NA NA NA hsa-miR-92a-3p PPARA -0.0407239381334215 0.643983393806323 0.335389759038066 2.96327925124771e-07 mirMAP -0.118084605000798 0.0106626711733628 NA NA NA hsa-miR-93-5p PPARA -0.139766237971079 0.101057320076733 0.335389759038066 2.96327925124771e-07 miRNATAP -0.269330293252548 3.61729508947317e-09 NA NA NA hsa-miR-20a-5p PREX1 0.0115865752289119 0.887069448775761 -0.0341224368475075 0.676763599409125 MirTarget;miRNATAP -0.130385032769951 0.00376118056491825 NA NA NA hsa-miR-2355-5p RBM14 -0.00808596988209409 0.91616550115528 -0.0372682125999351 0.34537512312981 MirTarget -0.12491138937187 1.07668129644885e-21 NA NA NA hsa-let-7d-5p RICTOR -0.111345229817881 0.0872634398337596 0.340817529238972 9.72373497855026e-07 MirTarget;miRNATAP -0.366185012216506 5.69848512950854e-13 NA NA NA hsa-let-7e-5p RICTOR -0.0471189209570024 0.657255455444874 0.340817529238972 9.72373497855026e-07 MirTarget;miRNATAP -0.219844631645267 9.34431457732824e-14 NA NA NA hsa-let-7f-1-3p RICTOR -0.110713086694052 0.214845243005185 0.340817529238972 9.72373497855026e-07 MirTarget -0.18551704770112 6.29069484832912e-10 NA NA NA hsa-let-7f-5p RICTOR -0.0508269185845212 0.626775150458244 0.340817529238972 9.72373497855026e-07 MirTarget;miRNATAP -0.128396059260989 0.000181315224300277 NA NA NA hsa-let-7g-5p RICTOR 0.025339633460872 0.742556489443337 0.340817529238972 9.72373497855026e-07 MirTarget;miRNATAP -0.168335879823563 0.000259122914146362 NA NA NA hsa-let-7i-5p RICTOR -0.0952853587923013 0.192120688957357 0.340817529238972 9.72373497855026e-07 MirTarget;miRNATAP -0.236335804494887 5.14669081578208e-07 NA NA NA hsa-miR-1301-3p RICTOR 0.105695714210774 0.152249184194069 0.340817529238972 9.72373497855026e-07 MirTarget -0.230426812841658 1.15566895307326e-09 NA NA NA hsa-miR-141-3p RICTOR -0.411205619919922 0.000393344390969032 0.340817529238972 9.72373497855026e-07 MirTarget -0.171392968001866 1.95588251346862e-13 NA NA NA hsa-miR-142-3p RICTOR -0.558908907203953 1.37828834702525e-05 0.340817529238972 9.72373497855026e-07 MirTarget;PITA;miRanda;miRNATAP -0.184109249383188 2.19602910499462e-18 NA NA NA hsa-miR-142-5p RICTOR -0.434884875454099 0.000575570345702933 0.340817529238972 9.72373497855026e-07 PITA;mirMAP -0.190450284071925 2.58036051523203e-20 NA NA NA hsa-miR-148a-3p RICTOR -0.30682159249341 0.039235695888613 0.340817529238972 9.72373497855026e-07 MirTarget;miRNATAP -0.225144093233634 5.13508442140085e-36 NA NA NA hsa-miR-148b-3p RICTOR -0.0710353380371309 0.322794068460372 0.340817529238972 9.72373497855026e-07 MirTarget -0.296261168065746 4.98470682637344e-12 NA NA NA hsa-miR-155-5p RICTOR -0.969837380981077 5.86551495710366e-15 0.340817529238972 9.72373497855026e-07 miRNAWalker2_validate;miRNATAP -0.291238178583799 1.32438389659014e-51 NA NA NA hsa-miR-15a-5p RICTOR -0.142658985373589 0.0536219185009377 0.340817529238972 9.72373497855026e-07 MirTarget;miRNATAP -0.298045123440301 9.39387440736874e-12 NA NA NA hsa-miR-15b-3p RICTOR -0.690804403863834 8.4878475512421e-09 0.340817529238972 9.72373497855026e-07 mirMAP -0.217466201885051 1.58849324219008e-24 NA NA NA hsa-miR-15b-5p RICTOR -0.59286315669281 1.41971517354318e-10 0.340817529238972 9.72373497855026e-07 MirTarget;miRNATAP -0.337396339070396 4.97239627439238e-31 NA NA NA hsa-miR-16-1-3p RICTOR -0.346674816118499 1.8644785016764e-05 0.340817529238972 9.72373497855026e-07 MirTarget -0.18608896869609 2.50675945169486e-08 NA NA NA hsa-miR-16-5p RICTOR -0.246024668671255 0.00346042804504067 0.340817529238972 9.72373497855026e-07 MirTarget;miRNATAP -0.221070179523461 4.60948390047702e-09 NA NA NA hsa-miR-185-5p RICTOR 0.0767432095218483 0.404113540276702 0.340817529238972 9.72373497855026e-07 MirTarget -0.170704638663266 3.44966160760204e-08 NA NA NA hsa-miR-186-5p RICTOR -0.060638189413023 0.514217717592655 0.340817529238972 9.72373497855026e-07 mirMAP -0.166057942291897 2.09413091268972e-07 NA NA NA hsa-miR-18a-5p RICTOR -0.175320895022842 0.0732549187136405 0.340817529238972 9.72373497855026e-07 miRNAWalker2_validate -0.13919802152168 4.04129549096482e-07 NA NA NA hsa-miR-204-5p RICTOR 0.288588537398083 0.113371226435799 0.340817529238972 9.72373497855026e-07 MirTarget -0.145826898817978 2.11241791153632e-24 NA NA NA hsa-miR-27a-3p RICTOR -0.30376003289577 0.00457375391190104 0.340817529238972 9.72373497855026e-07 miRNATAP -0.21959127497515 1.91381984711079e-16 NA NA NA hsa-miR-27b-3p RICTOR 0.0599187745243448 0.582081434759731 0.340817529238972 9.72373497855026e-07 miRNATAP -0.177158253165587 7.12809938693104e-11 NA NA NA hsa-miR-30a-3p RICTOR -0.0655410309550497 0.509541256242263 0.340817529238972 9.72373497855026e-07 MirTarget;miRNATAP -0.308551330177004 3.90261073731891e-19 NA NA NA hsa-miR-30d-3p RICTOR -0.0854049347792865 0.206912548011228 0.340817529238972 9.72373497855026e-07 MirTarget;miRNATAP -0.235159544146309 4.45676376769869e-09 NA NA NA hsa-miR-30e-3p RICTOR -0.00173769765871867 0.98496550154767 0.340817529238972 9.72373497855026e-07 MirTarget -0.232388809445674 5.61390782290066e-09 NA NA NA hsa-miR-324-3p RICTOR 0.0103367134443824 0.904494071317889 0.340817529238972 9.72373497855026e-07 MirTarget;PITA -0.1294765445569 7.61328463367635e-05 NA NA NA hsa-miR-331-5p RICTOR -0.00538076980695268 0.94283368596328 0.340817529238972 9.72373497855026e-07 PITA -0.213999650151533 2.71520590109557e-09 NA NA NA hsa-miR-335-5p RICTOR -0.0938511632756835 0.336889056387767 0.340817529238972 9.72373497855026e-07 miRNAWalker2_validate -0.11553010021071 4.39787377600229e-05 NA NA NA hsa-miR-342-3p RICTOR 0.125683829770898 0.105810751640081 0.340817529238972 9.72373497855026e-07 MirTarget;PITA;miRanda;miRNATAP -0.137942536903342 0.000435023034377486 NA NA NA hsa-miR-365a-3p RICTOR 0.184222766207935 0.0292663235724032 0.340817529238972 9.72373497855026e-07 MirTarget -0.23825980761403 1.64609178740656e-13 NA NA NA hsa-miR-424-5p RICTOR -0.251403740496744 0.00709934939775351 0.340817529238972 9.72373497855026e-07 MirTarget;miRNATAP -0.117291798451838 0.00011319803960031 NA NA NA hsa-miR-452-5p RICTOR -0.599327068454216 1.02031931068513e-05 0.340817529238972 9.72373497855026e-07 mirMAP -0.145719448866168 5.39481311969316e-14 NA NA NA hsa-miR-455-3p RICTOR -0.51270181640209 0.000459755983280324 0.340817529238972 9.72373497855026e-07 MirTarget;PITA;miRNATAP -0.156921582712592 4.80985313217028e-18 NA NA NA hsa-miR-500a-5p RICTOR -0.0634452729978798 0.396072382601725 0.340817529238972 9.72373497855026e-07 MirTarget;mirMAP -0.267950227114605 6.95606635539543e-14 NA NA NA hsa-miR-501-5p RICTOR -0.0878951859817464 0.309663377222435 0.340817529238972 9.72373497855026e-07 PITA -0.221938409661523 7.54513025040338e-13 NA NA NA hsa-miR-576-5p RICTOR -0.106482276040039 0.194379152564202 0.340817529238972 9.72373497855026e-07 PITA;mirMAP -0.17634170781602 1.19078498816092e-07 NA NA NA hsa-miR-590-3p RICTOR -0.312951515438399 0.00048045542384394 0.340817529238972 9.72373497855026e-07 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.210172011491685 1.52564599443315e-12 NA NA NA hsa-miR-654-3p RICTOR 0.00355488592828523 0.979671440962753 0.340817529238972 9.72373497855026e-07 MirTarget;PITA;miRNATAP -0.104790123738468 6.86372679519284e-08 NA NA NA hsa-miR-660-5p RICTOR 0.138989893523989 0.0945491063873115 0.340817529238972 9.72373497855026e-07 MirTarget -0.112113292712561 0.00156330481036737 NA NA NA hsa-miR-760 RICTOR 0.137843834465103 0.266726472033799 0.340817529238972 9.72373497855026e-07 miRNATAP -0.102716018404033 2.1323779256292e-06 NA NA NA hsa-miR-98-5p RICTOR 0.0806971683871804 0.251777941211574 0.340817529238972 9.72373497855026e-07 MirTarget -0.224688427746988 2.37944610696123e-07 NA NA NA hsa-miR-130b-3p SDC4 -0.503911467685704 9.4659058895114e-08 0.122041312433335 0.460845715628669 MirTarget -0.283353084530411 0.00020231593205631 NA NA NA hsa-miR-29b-1-5p SEPT2 -0.191335428755769 0.0084643645479085 0.0563250039174541 0.388291891129519 MirTarget -0.138298223988049 2.33182974540386e-10 NA NA NA hsa-miR-342-3p SEPT2 0.125683829770898 0.105810751640081 0.0563250039174541 0.388291891129519 miRanda -0.153847840756735 1.75307610747778e-11 NA NA NA hsa-miR-361-5p SEPT2 -0.0107519600643009 0.882230614095884 0.0563250039174541 0.388291891129519 miRanda -0.168556421476976 5.83889828243305e-10 NA NA NA hsa-miR-106a-5p SOX4 -0.110074064773885 0.130458159906254 -0.130399677516149 0.285587017757533 MirTarget;miRNATAP -0.314114998827184 1.18684747928322e-05 NA NA NA hsa-miR-129-5p SOX4 0.567133990117154 0.00116152215679873 -0.130399677516149 0.285587017757533 miRNAWalker2_validate;miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.123517646937467 1.74946704089023e-05 19487295;23677061 Using luciferase assays we documented a direct link between miR-129 and the two putative targets GALNT1 and SOX4;miR 129 2 suppresses proliferation and migration of esophageal carcinoma cells through downregulation of SOX4 expression ; bladder cancer;esophageal cancer hsa-miR-132-3p SOX4 0.178379362833879 0.133352008771241 -0.130399677516149 0.285587017757533 miRNATAP -0.358282913081379 5.98753323548452e-17 26352673;27527117;26543603 MicroRNA 132 inhibits cell growth and metastasis in osteosarcoma cell lines possibly by targeting Sox4;Immunohistochemistry IHC was used to detect the expression of SOX4 miR-132 and miR-212 from the same gene cluster are downregulated in human PCa tissues when compared with benign prostatic hyperplasia tissues both P < 0.05;miR 132 inhibits lung cancer cell migration and invasion by targeting SOX4; Further studies indicated that the sex determining region Y-box 4 SOX4 is a target gene of miR-132; SOX4 re-introduction could reverse the anti-invasion role of miR-132 metastasis;;cell migration sarcoma;prostate cancer;lung cancer hsa-miR-138-5p SOX4 0.61608764992087 1.35200027885651e-05 -0.130399677516149 0.285587017757533 miRNAWalker2_validate;MirTarget;miRNATAP -0.176228798042081 3.86797942730557e-07 23389731 Results indicated that miR-138 directly targeted SRY-related high mobility group box 4 SOX4 and hypoxia-inducible factor-1α HIF-1α and overexpression of SOX4 and HIF-1α effectively reversed the miR-138-mediated suppression of cell invasion; Analysis of human ovarian tumors further revealed downregulation of miR-138 and upregulation of SOX4 in late-stage tumors; Our study demonstrates the role and clinical relevance of miR-138 in ovarian cancer cell invasion and metastasis providing a potential therapeutic strategy for suppression of ovarian cancer metastasis by targeting SOX4 and HIF-1α pathways staging;metastasis ovarian cancer hsa-miR-139-3p SOX4 0.697844024219997 4.41573169040404e-06 -0.130399677516149 0.285587017757533 miRNATAP -0.104098811058732 0.00142499033103752 NA NA NA hsa-miR-140-5p SOX4 -0.0650635071034511 0.380452509211897 -0.130399677516149 0.285587017757533 PITA;miRanda;miRNATAP -0.369624421262776 2.69738656146897e-07 27353653 MicroRNA 140 Inhibits Cell Proliferation in Gastric Cancer Cell Line HGC 27 by Suppressing SOX4; SOX4 a predicted target of miR-140 was mutated to verify its regulation by miR-140 and was overexpressed to analyze its function in cell proliferation; miR-140 suppressed SOX4 expression via binding to the 3' untranslated region while the mutant SOX4 could not be regulated; CONCLUSIONS These findings suggest that miR-140 directly inhibits SOX4 which might be one of its mechanisms in suppressing gastric cancer cell proliferation gastric cancer hsa-miR-145-5p SOX4 -0.108948399942988 0.310032352776812 -0.130399677516149 0.285587017757533 mirMAP -0.415500655494226 1.43947248320177e-18 NA NA NA hsa-miR-146b-3p SOX4 -0.283486177568232 0.0118918188864908 -0.130399677516149 0.285587017757533 PITA -0.536107774043466 4.13875897270837e-38 NA NA NA hsa-miR-151a-5p SOX4 0.040489766030599 0.549545497146945 -0.130399677516149 0.285587017757533 miRNAWalker2_validate -0.610202720601545 6.48721087332988e-14 NA NA NA hsa-miR-154-5p SOX4 0.226468848904459 0.107380908211265 -0.130399677516149 0.285587017757533 mirMAP -0.184354161952379 1.25397910214081e-07 NA NA NA hsa-miR-185-3p SOX4 0.133219014400352 0.25571381872824 -0.130399677516149 0.285587017757533 MirTarget;miRNATAP -0.261085237016745 3.26808093774284e-10 NA NA NA hsa-miR-191-5p SOX4 -0.0973986771912454 0.220078671774191 -0.130399677516149 0.285587017757533 miRNAWalker2_validate;miRNATAP -0.57365638945098 1.84057279811087e-14 NA NA NA hsa-miR-199a-5p SOX4 -0.174889610847956 0.0900027418912677 -0.130399677516149 0.285587017757533 miRanda;miRNATAP -0.428546927951135 6.83969703920428e-20 NA NA NA hsa-miR-199b-5p SOX4 -0.436298593972863 0.00200225454383867 -0.130399677516149 0.285587017757533 miRanda -0.23977134784947 2.22193325044374e-12 NA NA NA hsa-miR-204-5p SOX4 0.288588537398083 0.113371226435799 -0.130399677516149 0.285587017757533 miRNAWalker2_validate;miRNATAP -0.312612146837406 1.3321295375604e-34 26323722;24984017 Upregulation of microRNA 204 inhibits cell proliferation migration and invasion in human renal cell carcinoma cells by downregulating SOX4;Decreased miR 204 in H pylori associated gastric cancer promotes cancer cell proliferation and invasion by targeting SOX4; Luciferase assay revealed that SOX4 was target gene of miR-204 which was found up-regulated in H pylori positive tissues; Down-regulation of miR-204 and over-expression of SOX4 promoted epithelial-mesenchymal transition process; Taken together our findings demonstrated that miR-204 may act as a tumor suppressor in H pylori induced gastric cancer by targeting SOX4 ; kidney renal cell cancer;gastric cancer hsa-miR-20b-5p SOX4 -0.144541062989457 0.099204233355698 -0.130399677516149 0.285587017757533 MirTarget;miRNATAP -0.299397321224074 7.14292919300423e-07 NA NA NA hsa-miR-212-3p SOX4 0.0141129412093419 0.918360379513015 -0.130399677516149 0.285587017757533 miRNATAP -0.278561845927105 1.74083347246032e-15 27527117;25562164 Immunohistochemistry IHC was used to detect the expression of SOX4 miR-132 and miR-212 from the same gene cluster are downregulated in human PCa tissues when compared with benign prostatic hyperplasia tissues both P < 0.05;MicroRNA 212 inhibits osteosarcoma cells proliferation and invasion by down regulation of Sox4; Additionally bioinformatic prediction suggested that the sex-determining region Y-box 4 Sox4 is a target gene of miR-212; Sox4 inhibition phenocopied the roles of miR-212 while restored expression of Sox4 dampened miR-212-mediated suppression of tumor progression ;progression prostate cancer;sarcoma hsa-miR-2355-5p SOX4 -0.00808596988209409 0.91616550115528 -0.130399677516149 0.285587017757533 mirMAP -0.573885079659246 2.45704383306572e-18 NA NA NA hsa-miR-299-5p SOX4 0.0814737109317376 0.576202442267832 -0.130399677516149 0.285587017757533 MirTarget;PITA;miRNATAP -0.206269847360089 1.15468812013236e-09 NA NA NA hsa-miR-29a-5p SOX4 0.0697727833812762 0.350621682973061 -0.130399677516149 0.285587017757533 miRNATAP -0.364398840828449 5.28327618597599e-08 NA NA NA hsa-miR-30a-3p SOX4 -0.0655410309550497 0.509541256242263 -0.130399677516149 0.285587017757533 mirMAP -0.68241992923904 1.50577289359874e-28 25572678 Association of SOX4 regulated by tumor suppressor miR 30a with poor prognosis in low grade chondrosarcoma; In an attempt of characterizing SOX4 overexpression mechanism we identified miR-30a as a tumor suppressor that directly targets SOX4 in chondrosarcoma cells; Clinically miR-30a expression was negatively correlated with SOX4 expression in chondrosarcoma cases; In all we identified that SOX4 was oncogenic in chondrosarcoma and negatively regulated by miR-30a in vitro worse prognosis sarcoma hsa-miR-30a-5p SOX4 0.0629429366112948 0.513851954699872 -0.130399677516149 0.285587017757533 miRNATAP -1.13086082628389 1.33435394564135e-48 25572678 Association of SOX4 regulated by tumor suppressor miR 30a with poor prognosis in low grade chondrosarcoma; In an attempt of characterizing SOX4 overexpression mechanism we identified miR-30a as a tumor suppressor that directly targets SOX4 in chondrosarcoma cells; Clinically miR-30a expression was negatively correlated with SOX4 expression in chondrosarcoma cases; In all we identified that SOX4 was oncogenic in chondrosarcoma and negatively regulated by miR-30a in vitro worse prognosis sarcoma hsa-miR-30b-5p SOX4 0.085810101632239 0.263243418521696 -0.130399677516149 0.285587017757533 miRNAWalker2_validate -0.518341172255712 1.22691031857467e-11 NA NA NA hsa-miR-30c-5p SOX4 0.0469114469943488 0.565934557464302 -0.130399677516149 0.285587017757533 miRNAWalker2_validate;miRNATAP -0.660904765067482 2.56583449924773e-18 NA NA NA hsa-miR-30d-5p SOX4 0.0607010868720561 0.471410043548418 -0.130399677516149 0.285587017757533 miRNATAP -0.746429920304922 5.57512388890792e-18 NA NA NA hsa-miR-30e-3p SOX4 -0.00173769765871867 0.98496550154767 -0.130399677516149 0.285587017757533 mirMAP -0.564723322280283 3.09249716364566e-15 NA NA NA hsa-miR-32-5p SOX4 -0.130313603388213 0.177843055266183 -0.130399677516149 0.285587017757533 MirTarget;miRNATAP -0.226333358402205 1.2820760592061e-05 NA NA NA hsa-miR-320c SOX4 -0.343259124189967 0.000248338401291042 -0.130399677516149 0.285587017757533 PITA;miRanda;miRNATAP -0.144936886538408 0.00755638592674854 NA NA NA hsa-miR-335-3p SOX4 -0.345405843355925 0.000438486602223359 -0.130399677516149 0.285587017757533 mirMAP -0.263608466023613 3.45197365934025e-07 22034498 Both TCDD and MCDF induced miR-335 in MDA-MB-231 and BT474 cells and this was accompanied by downregulation of SOX4 a miR-335-regulated inhibited gene breast cancer hsa-miR-335-5p SOX4 -0.0938511632756835 0.336889056387767 -0.130399677516149 0.285587017757533 miRNAWalker2_validate;miRTarBase -0.147456459292727 0.00431589023257125 22034498 Both TCDD and MCDF induced miR-335 in MDA-MB-231 and BT474 cells and this was accompanied by downregulation of SOX4 a miR-335-regulated inhibited gene breast cancer hsa-miR-338-3p SOX4 0.399637046793888 0.00344106432206527 -0.130399677516149 0.285587017757533 miRNATAP -0.197863726932147 5.12721534099703e-07 26252944;27508100;27186391 MicroRNA 338 3p functions as tumor suppressor in breast cancer by targeting SOX4;Erratum: MicroRNA 338 3p suppresses metastasis of lung cancer cells by targeting the EMT regulator Sox4;MicroRNA 338 3p suppresses metastasis of lung cancer cells by targeting the EMT regulator Sox4; Further studies indicated that the EMT-related transcription factor Sox4 was one direct target gene of miR-338-3p evidenced by the direct binding of miR-338-3p with the 3'untranslated region 3'UTR of Sox4; Furthermore miR-338-3p could decrease the expression of Sox4 both at mRNA and protein levels; Additionally over-expressing or silencing Sox4 could elevate or inhibit the migration and invasion of lung cancer cells parallel to the effect of miR-338-3p on the lung cancer cells; Meanwhile knockdown of Sox4 reversed the enhanced migration and invasion mediated by miR-338-3p; These results indicated that miR-338-3p suppressed the migration and invasion of NSCLC cells through targeting Sox4 involving in the EMT process ;metastasis;metastasis breast cancer;lung cancer;lung cancer hsa-miR-339-5p SOX4 -0.273253751377135 0.0185300170790711 -0.130399677516149 0.285587017757533 miRanda -0.365313749308486 8.26464295126841e-19 NA NA NA hsa-miR-340-5p SOX4 0.110504550202752 0.205224261934695 -0.130399677516149 0.285587017757533 miRNAWalker2_validate -0.157555163820046 0.00926968373527559 NA NA NA hsa-miR-342-5p SOX4 -0.0383784541944334 0.544128449296234 -0.130399677516149 0.285587017757533 MirTarget;PITA;miRNATAP -0.403157758178636 4.11617585586963e-07 NA NA NA hsa-miR-34a-5p SOX4 -0.143472919835505 0.211283228567119 -0.130399677516149 0.285587017757533 miRNATAP -0.644851957660451 9.71031778608541e-61 NA NA NA hsa-miR-34c-5p SOX4 -0.181931113688087 0.257266965617378 -0.130399677516149 0.285587017757533 PITA;miRanda;miRNATAP -0.279345366334266 1.74616276484956e-21 NA NA NA hsa-miR-361-5p SOX4 -0.0107519600643009 0.882230614095884 -0.130399677516149 0.285587017757533 miRanda -0.680553011604939 1.46102819571072e-16 NA NA NA hsa-miR-362-3p SOX4 -0.032375035235532 0.736465332563774 -0.130399677516149 0.285587017757533 miRanda;miRNATAP -0.30762928128212 1.48346722557877e-09 NA NA NA hsa-miR-363-3p SOX4 0.0500185604139265 0.527823314542852 -0.130399677516149 0.285587017757533 MirTarget -0.392396619335776 2.48691679670095e-09 27084453 MiR 363 3p inhibits the epithelial to mesenchymal transition and suppresses metastasis in colorectal cancer by targeting Sox4; Analysis of the underlying mechanisms revealed that miR-363-3p could regulate Sox4 expression by directly targeting its 3'untranslated region; Down-regulation of miR-363-3p increased Sox4 expression and induced EMT while overexpression of miR-363-3p decreased Sox4 expression; Taken together our findings indicate that miR-363-3p is involved in CRC metastasis and functions as a tumor suppressor via negatively regulating Sox4 metastasis colorectal cancer hsa-miR-369-3p SOX4 0.153496605399653 0.296055925448093 -0.130399677516149 0.285587017757533 PITA;miRNATAP -0.20942185642701 3.08015589527355e-10 NA NA NA hsa-miR-381-3p SOX4 0.192118086401452 0.203198554750038 -0.130399677516149 0.285587017757533 MirTarget -0.224691339451082 4.28108345500225e-12 NA NA NA hsa-miR-421 SOX4 0.171573235029884 0.0518112933650958 -0.130399677516149 0.285587017757533 PITA;miRanda;miRNATAP -0.227714925906318 4.94537822830768e-05 NA NA NA hsa-miR-490-3p SOX4 0.834268051506887 5.26203010743174e-06 -0.130399677516149 0.285587017757533 miRanda -0.125989765673664 3.07754045050692e-06 NA NA NA hsa-miR-496 SOX4 0.139833482232875 0.395975418625328 -0.130399677516149 0.285587017757533 miRanda -0.183041011285517 1.05727035512173e-09 NA NA NA hsa-miR-500a-5p SOX4 -0.0634452729978798 0.396072382601725 -0.130399677516149 0.285587017757533 miRNATAP -0.543778043956641 4.11902332152091e-17 NA NA NA hsa-miR-501-5p SOX4 -0.0878951859817464 0.309663377222435 -0.130399677516149 0.285587017757533 MirTarget;PITA;miRNATAP -0.443052038963013 2.65128789239442e-15 NA NA NA hsa-miR-539-5p SOX4 0.326485413953599 0.0554453076411236 -0.130399677516149 0.285587017757533 miRNATAP -0.16460773449029 8.16318802369394e-09 NA NA NA hsa-miR-590-3p SOX4 -0.312951515438399 0.00048045542384394 -0.130399677516149 0.285587017757533 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.308636054982608 1.52033140362528e-08 NA NA NA hsa-miR-590-5p SOX4 -0.169460270359482 0.0386004382081766 -0.130399677516149 0.285587017757533 miRanda -0.324854717047496 8.0018829240914e-08 NA NA NA hsa-miR-7-1-3p SOX4 0.0894475316162513 0.373223597851017 -0.130399677516149 0.285587017757533 mirMAP -0.40400499815533 5.35775500834125e-17 NA NA NA hsa-miR-92b-3p SOX4 0.213968504162006 0.0523921855715249 -0.130399677516149 0.285587017757533 MirTarget;miRNATAP -0.111093706691391 0.0337833475317815 NA NA NA hsa-miR-98-5p SOX4 0.0806971683871804 0.251777941211574 -0.130399677516149 0.285587017757533 miRNAWalker2_validate -0.570122961662702 2.96822612935851e-13 NA NA NA hsa-miR-9-3p STIM2 0.184945845984739 0.0290051908008628 -0.156823871881451 0.00271277758571079 MirTarget;miRNATAP -0.163047654459699 4.54033245256704e-08 NA NA NA hsa-miR-126-5p TCF12 -0.177332403948646 0.0711675116243408 0.0846606700441832 0.395208781788766 MirTarget;miRNATAP -0.269213563798053 6.22754514583424e-12 NA NA NA hsa-miR-129-5p TCF12 0.567133990117154 0.00116152215679873 0.0846606700441832 0.395208781788766 miRanda -0.107966809301207 6.33814712155452e-07 NA NA NA hsa-miR-137 TCF12 0.924849266740897 1.54683220204945e-06 0.0846606700441832 0.395208781788766 MirTarget;PITA;miRanda;miRNATAP -0.141089480627729 4.92678495692347e-14 NA NA NA hsa-miR-139-5p TCF12 0.647754756897662 2.1537830723695e-06 0.0846606700441832 0.395208781788766 MirTarget;PITA;miRanda;miRNATAP -0.114082687061418 4.74476598648645e-05 NA NA NA hsa-miR-141-3p TCF12 -0.411205619919922 0.000393344390969032 0.0846606700441832 0.395208781788766 MirTarget;TargetScan;miRNATAP -0.305593635736039 2.75099970202952e-22 NA NA NA hsa-miR-142-5p TCF12 -0.434884875454099 0.000575570345702933 0.0846606700441832 0.395208781788766 MirTarget;PITA;mirMAP;miRNATAP -0.254821988716244 3.19600342888515e-19 NA NA NA hsa-miR-149-5p TCF12 0.0535821592030219 0.65771389201239 0.0846606700441832 0.395208781788766 MirTarget;miRNATAP -0.385529062959615 1.2807281595157e-39 NA NA NA hsa-miR-150-5p TCF12 -0.0645271721519425 0.51329565882884 0.0846606700441832 0.395208781788766 miRNATAP -0.331082954803479 4.12354458281064e-18 NA NA NA hsa-miR-154-5p TCF12 0.226468848904459 0.107380908211265 0.0846606700441832 0.395208781788766 MirTarget;miRNATAP -0.22544891344633 2.18816642653873e-18 NA NA NA hsa-miR-155-5p TCF12 -0.969837380981077 5.86551495710366e-15 0.0846606700441832 0.395208781788766 miRNAWalker2_validate -0.323025223122179 1.38132584892878e-31 NA NA NA hsa-miR-15b-3p TCF12 -0.690804403863834 8.4878475512421e-09 0.0846606700441832 0.395208781788766 mirMAP -0.206772722773471 6.01266146528081e-12 NA NA NA hsa-miR-185-5p TCF12 0.0767432095218483 0.404113540276702 0.0846606700441832 0.395208781788766 MirTarget;miRNATAP -0.384906826167687 1.65978913782705e-20 NA NA NA hsa-miR-199a-3p TCF12 -0.412263318710744 0.000497136154474781 0.0846606700441832 0.395208781788766 mirMAP -0.273550873100127 9.83466048513931e-19 NA NA NA hsa-miR-199b-3p TCF12 -0.411848361704378 0.000517815011892612 0.0846606700441832 0.395208781788766 mirMAP -0.272181139634388 1.24282599016534e-18 NA NA NA hsa-miR-203a-3p TCF12 0.39304131060377 0.0191851699904027 0.0846606700441832 0.395208781788766 MirTarget -0.16049144055106 1.45607103307931e-13 NA NA NA hsa-miR-204-5p TCF12 0.288588537398083 0.113371226435799 0.0846606700441832 0.395208781788766 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.237355453271415 6.21839930791139e-35 NA NA NA hsa-miR-218-5p TCF12 0.534287404275844 0.00308322441944715 0.0846606700441832 0.395208781788766 MirTarget -0.19670186296244 1.5111804592704e-23 NA NA NA hsa-miR-221-3p TCF12 0.010950728507197 0.936440693394406 0.0846606700441832 0.395208781788766 MirTarget;miRNATAP -0.363816226419583 1.23660492522296e-47 NA NA NA hsa-miR-222-3p TCF12 -0.107117065575191 0.423818119725726 0.0846606700441832 0.395208781788766 MirTarget;miRNATAP -0.362243414722846 4.78778727859664e-46 NA NA NA hsa-miR-26a-5p TCF12 -0.033823776747262 0.726610414342617 0.0846606700441832 0.395208781788766 miRNATAP -0.374292883265764 2.42917856244748e-16 NA NA NA hsa-miR-26b-5p TCF12 0.0984536538763106 0.231803769574464 0.0846606700441832 0.395208781788766 miRNAWalker2_validate;miRNATAP -0.371494263262069 3.57352907076372e-12 NA NA NA hsa-miR-29b-1-5p TCF12 -0.191335428755769 0.0084643645479085 0.0846606700441832 0.395208781788766 MirTarget -0.401333222700398 1.12866711573718e-15 NA NA NA hsa-miR-330-3p TCF12 0.427388106938161 0.003004892844142 0.0846606700441832 0.395208781788766 mirMAP;miRNATAP -0.191805164830222 2.74739126538964e-14 NA NA NA hsa-miR-330-5p TCF12 0.262932095995619 0.0465226565966542 0.0846606700441832 0.395208781788766 miRanda -0.233893047830977 1.74807459803842e-17 NA NA NA hsa-miR-331-5p TCF12 -0.00538076980695268 0.94283368596328 0.0846606700441832 0.395208781788766 PITA -0.421657406876531 3.92949288837603e-18 NA NA NA hsa-miR-338-5p TCF12 0.424003687569646 0.00246415720301228 0.0846606700441832 0.395208781788766 miRNATAP -0.10520394368684 8.97635656358387e-05 NA NA NA hsa-miR-33a-3p TCF12 0.15836637661919 0.0991512910387245 0.0846606700441832 0.395208781788766 MirTarget -0.154316307293325 7.64475757308681e-05 NA NA NA hsa-miR-342-3p TCF12 0.125683829770898 0.105810751640081 0.0846606700441832 0.395208781788766 MirTarget;PITA;miRanda -0.490758923992505 4.0450447544027e-21 NA NA NA hsa-miR-34a-5p TCF12 -0.143472919835505 0.211283228567119 0.0846606700441832 0.395208781788766 MirTarget;miRNATAP -0.466407985290866 2.18212173456e-54 NA NA NA hsa-miR-34c-5p TCF12 -0.181931113688087 0.257266965617378 0.0846606700441832 0.395208781788766 MirTarget;PITA;miRanda;miRNATAP -0.204190374767131 4.45010626530761e-20 NA NA NA hsa-miR-369-3p TCF12 0.153496605399653 0.296055925448093 0.0846606700441832 0.395208781788766 PITA;mirMAP;miRNATAP -0.22848449791326 1.62483855535124e-20 NA NA NA hsa-miR-374a-5p TCF12 -0.0121037060909126 0.865417963346047 0.0846606700441832 0.395208781788766 MirTarget -0.149428129096288 0.00828760847555676 NA NA NA hsa-miR-375 TCF12 0.0268401141324208 0.858358101444604 0.0846606700441832 0.395208781788766 miRNAWalker2_validate;miRanda;miRNATAP -0.240462891457435 2.93783333053786e-24 NA NA NA hsa-miR-380-5p TCF12 0.356387125389105 0.0163515117264037 0.0846606700441832 0.395208781788766 miRNATAP -0.196531377537966 6.03708247972048e-15 NA NA NA hsa-miR-411-3p TCF12 0.239070412422695 0.0940658517658319 0.0846606700441832 0.395208781788766 mirMAP -0.211578527757112 3.02671573974387e-16 NA NA NA hsa-miR-508-3p TCF12 0.292045725850842 0.0158994578296532 0.0846606700441832 0.395208781788766 miRNATAP -0.154686788473549 3.92139157156851e-07 NA NA NA hsa-miR-539-5p TCF12 0.326485413953599 0.0554453076411236 0.0846606700441832 0.395208781788766 MirTarget;miRNATAP -0.187152614053764 8.2939581107072e-19 NA NA NA hsa-miR-576-5p TCF12 -0.106482276040039 0.194379152564202 0.0846606700441832 0.395208781788766 mirMAP -0.283102453757889 5.2906256197455e-10 NA NA NA hsa-miR-582-5p TCF12 0.215764335500681 0.0760892640434293 0.0846606700441832 0.395208781788766 MirTarget;PITA;miRNATAP -0.210022716421427 2.27952349944864e-12 NA NA NA hsa-miR-590-3p TCF12 -0.312951515438399 0.00048045542384394 0.0846606700441832 0.395208781788766 miRanda -0.304368489160304 8.31818731664358e-14 NA NA NA hsa-miR-592 TCF12 -0.0170005651576393 0.876633091134892 0.0846606700441832 0.395208781788766 miRNATAP -0.112751297105807 0.000976616801363058 NA NA NA hsa-miR-7-1-3p TCF12 0.0894475316162513 0.373223597851017 0.0846606700441832 0.395208781788766 mirMAP -0.390061036666943 6.68695051045615e-28 NA NA NA hsa-miR-7-5p TCF12 0.244254069762737 0.193173919522098 0.0846606700441832 0.395208781788766 MirTarget;miRNATAP -0.138872953114824 2.91601479124235e-12 NA NA NA hsa-miR-125a-5p TFAM 0.0833349424517795 0.32544020025337 0.0350849763449572 0.416574358396971 miRanda -0.157645412375982 1.15545008536008e-13 NA NA NA hsa-miR-1976 TFAM -0.127074435034709 0.277235601775441 0.0350849763449572 0.416574358396971 MirTarget -0.110671423968668 1.56642396991546e-19 NA NA NA hsa-miR-23b-3p TFAM -0.0476610245859863 0.630277683372509 0.0350849763449572 0.416574358396971 MirTarget;miRNATAP -0.115178745107901 3.51993625350804e-12 NA NA NA hsa-miR-26a-5p TFAM -0.033823776747262 0.726610414342617 0.0350849763449572 0.416574358396971 miRNAWalker2_validate -0.118385525899924 1.29634916219379e-10 NA NA NA hsa-miR-335-3p TFAM -0.345405843355925 0.000438486602223359 0.0350849763449572 0.416574358396971 mirMAP -0.120450125403538 3.82202188537929e-15 NA NA NA hsa-miR-34a-5p TFAM -0.143472919835505 0.211283228567119 0.0350849763449572 0.416574358396971 miRNAWalker2_validate -0.156119269948258 3.28086205368298e-36 NA NA NA hsa-miR-484 TFAM 0.0190828819137927 0.802298900989454 0.0350849763449572 0.416574358396971 miRNAWalker2_validate -0.11473757968013 3.46226428234974e-08 NA NA NA hsa-miR-664a-3p TFAM -0.0413918462466984 0.611334357897205 0.0350849763449572 0.416574358396971 mirMAP -0.176032624344624 2.03613040222269e-22 NA NA NA hsa-miR-17-5p TRPM3 -0.097575136916686 0.206211102146113 0.668764910359271 0.000664298576590935 TargetScan -0.586463421706094 2.32434640120659e-05 NA NA NA hsa-miR-320a TRPM3 -0.0921355996367019 0.243028758990046 0.668764910359271 0.000664298576590935 miRanda -0.38745459551485 0.00477427874119667 NA NA NA hsa-miR-450b-5p TRPM3 -0.270544879013982 0.00801537838499814 0.668764910359271 0.000664298576590935 MirTarget;PITA;miRNATAP -0.252911660446653 0.003296205688853 NA NA NA hsa-miR-96-5p TRPM3 0.217255611810236 0.209932800103882 0.668764910359271 0.000664298576590935 TargetScan -0.15540503943583 0.00199127321744035 NA NA NA hsa-miR-19b-1-5p VAV3 -0.0686579042235513 0.332645627997482 -1.23062016321543 4.73992955192966e-12 mirMAP -0.232940587361146 0.042626699520829 NA NA NA hsa-miR-3065-5p VAV3 0.262608140481518 0.0414570974147947 -1.23062016321543 4.73992955192966e-12 mirMAP -0.377172357014513 7.45561526793734e-10 NA NA NA hsa-miR-374b-5p VAV3 0.210113949579637 0.00568660838185483 -1.23062016321543 4.73992955192966e-12 mirMAP -0.42330316090771 0.000372016921192189 NA NA NA hsa-miR-9-5p VAV3 0.125377971246515 0.269896477801932 -1.23062016321543 4.73992955192966e-12 MirTarget;miRNATAP -1.66891148539503 2.67226250022224e-23 NA NA NA hsa-miR-101-3p ZEB1 0.132333931567288 0.241891922291223 0.0669596779850563 0.391680686806474 MirTarget;miRNATAP -0.108887648588492 0.000812643393752297 24677166 MiR 101 suppresses the epithelial to mesenchymal transition by targeting ZEB1 and ZEB2 in ovarian carcinoma ovarian cancer hsa-miR-125a-3p ZEB1 -0.183834985432375 0.106230647107919 0.0669596779850563 0.391680686806474 miRanda -0.150592203333096 1.36429965442852e-09 NA NA NA hsa-miR-126-5p ZEB1 -0.177332403948646 0.0711675116243408 0.0669596779850563 0.391680686806474 mirMAP -0.117109974470009 0.000101007680701783 NA NA NA hsa-miR-140-5p ZEB1 -0.0650635071034511 0.380452509211897 0.0669596779850563 0.391680686806474 miRanda -0.123584410003896 0.00290122027574103 NA NA NA hsa-miR-141-3p ZEB1 -0.411205619919922 0.000393344390969032 0.0669596779850563 0.391680686806474 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.168267658278182 4.98958760638338e-12 24424572;24307282;26783187 Accordingly the enforced expression of miR-200c and mir-141 resulted in a significant upregulation in E-cadherin expression contrary to the significant downregulation in ZEB1 expression in 3 cell lines UTSCC-24A UTSCC-24B and UTSCC-6A cells;It is estimated that miR-141 played its role via ZEB1 and ZEB2; In all miR-141 played a osteosarcoma-suppressing role via ZEB1 and ZEB2;Nintedanib was able to reverse TGF-β1-induced EMT and resistance to gefitinib caused by miR-200b and miR-141 upregulation and ZEB1 downregulation ;;drug resistance head and neck cancer;sarcoma;lung squamous cell cancer hsa-miR-142-3p ZEB1 -0.558908907203953 1.37828834702525e-05 0.0669596779850563 0.391680686806474 miRanda;miRNATAP -0.154831437361684 3.2321721418626e-12 23342264 Two mutations in the seed sequence redirected miR-142-3p to the mRNA of the transcriptional repressor ZEB2 and one of them also targeted the ZEB1 mRNA; However the other mutations in the mature miR-142-3p did not influence either the ZEB1 or ZEB2 3' untranslated region 3' UTR B cell lymphoma hsa-miR-150-5p ZEB1 -0.0645271721519425 0.51329565882884 0.0669596779850563 0.391680686806474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.197194851958287 1.74470092815629e-11 25090005;23013135 MicroRNA 150 predicts a favorable prognosis in patients with epithelial ovarian cancer and inhibits cell invasion and metastasis by suppressing transcriptional repressor ZEB1; After that luciferase reporter assays demonstrated that Zinc Finger E-Box Binding Homeobox 1 ZEB1 a crucial regulator of epithelial-to-mesenchymal transition EMT was a direct target of miR-150 in EOC cells; Moreover we found that the ectopic expression of miR-150 could efficiently inhibit cell proliferation invasion and metastasis by suppressing the expression of ZEB1; Furthermore we also observed a significantly negative correlation between miR-150 and ZEB1 mRNA expression in EOC tissues rs = -0.45 P<0.001; Moreover our data reveal that miR-150 may function as a tumor suppressor and modulate EOC cell proliferation and invasion by directly and negatively regulating ZEB1 implying the re-expression of miR-150 might be a potential therapeutic strategy for EOC;MiR 150 is associated with poor prognosis in esophageal squamous cell carcinoma via targeting the EMT inducer ZEB1; Here we focused on ZEB1 epithelial-mesenchymal-transition EMT-inducer as a target gene of miR-150 based on in silico predictions; Moreover we examined the in vitro and in vivo function of miR-150 via degradation of ZEB1; Analysis of the regulation of ZEB1 by miR-150 could provide new insights into preventing metastasis and also suggests novel targeted therapeutic strategies in ESCC metastasis;worse prognosis;worse prognosis;metastasis ovarian cancer;esophageal cancer hsa-miR-16-1-3p ZEB1 -0.346674816118499 1.8644785016764e-05 0.0669596779850563 0.391680686806474 MirTarget -0.129411934871103 0.000225586046731557 NA NA NA hsa-miR-186-5p ZEB1 -0.060638189413023 0.514217717592655 0.0669596779850563 0.391680686806474 mirMAP;miRNATAP -0.217371471238617 5.00318389324031e-11 NA NA NA hsa-miR-194-5p ZEB1 0.122590607867661 0.10375508705371 0.0669596779850563 0.391680686806474 miRNATAP -0.123713592180666 0.00373838495587875 NA NA NA hsa-miR-199a-3p ZEB1 -0.412263318710744 0.000497136154474781 0.0669596779850563 0.391680686806474 PITA;miRNATAP -0.155547695545939 6.84365870948305e-11 NA NA NA hsa-miR-199a-5p ZEB1 -0.174889610847956 0.0900027418912677 0.0669596779850563 0.391680686806474 miRanda -0.205762895929508 3.96972108212965e-14 NA NA NA hsa-miR-199b-3p ZEB1 -0.411848361704378 0.000517815011892612 0.0669596779850563 0.391680686806474 PITA;miRNATAP -0.154496456665183 8.39009301463265e-11 NA NA NA hsa-miR-199b-5p ZEB1 -0.436298593972863 0.00200225454383867 0.0669596779850563 0.391680686806474 miRanda;miRNATAP -0.124910209762071 2.02560160746505e-10 NA NA NA hsa-miR-200b-3p ZEB1 -0.24576852650451 0.0580744465744749 0.0669596779850563 0.391680686806474 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.239985033011293 3.64646743841495e-30 24352645;27402864;27402080;23743934;24815002;24424572;20473948;26011542;19854497;26887977;24390222;27307751;26242262;19544444;23626803;26783187;24037528 Functional experiments demonstrated that miR-200b suppressed ZEB1 augmented E-cadherin inhibited cell migration and suppressed tumor growth in a mouse model;This circuit comprises the microRNA 200 miR-200 family ZEB1 and GRHL2;Conversely ectopic expression of miR-200 inhibited this sprouting by indirectly reducing the protein levels of PDGFRβ through the direct suppression of ZEB1;This finding was accompanied by a sharp downregulation in the expression of the miR-200 family of microRNAs well-known targets of ZEB1;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;ZEB1 is also known to repress miR-200c-141 transcription in a negative feedback loop but otherwise little is known about the transcriptional regulation of the miR-200 family and miR-205;Here we show that 53BP1 negatively regulated EMT by modulating ZEB1 through targeting microRNA miR-200b and miR-429; In 18 clinical tissue samples expression of 53BP1 was positively correlated with miR-200b and mir-429 and negatively correlated with ZEB1;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;GRHL2 miR 200 ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification;Inhibition of ZEB1 by miR 200 characterizes Helicobacter pylori positive gastric diffuse large B cell lymphoma with a less aggressive behavior; Through genome-wide expression profiles of both miRNAs and mRNAs in nine H pylori-positive and nine H pylori-negative gastric diffuse large B-cell lymphomas we identified inhibition of ZEB1 zinc-finger E-box-binding homeobox 1 by miR-200 in H pylori-positive gastric diffuse large B-cell lymphomas; In 30 H pylori-positive and 30 H pylori-negative gastric diffuse large B-cell lymphomas we confirmed that H pylori-positive gastric diffuse large B-cell lymphomas had higher levels of miR-200 by qRT-PCR and lower levels of ZEB1 and higher levels of BCL6 using immunohistochemistry;MicroRNA 200b acts as a tumor suppressor in osteosarcoma via targeting ZEB1; Moreover ZEB1 was identified as a target gene of miR-200b and its expression levels were negatively mediated by miR-200b in osteosarcoma cells; Based on these findings our study suggests that miR-200b inhibits the proliferation migration and invasion of osteosarcoma cells probably via the inhibition of ZEB1 expression;MiR 200 suppresses metastases of colorectal cancer through ZEB1; Here we showed that the levels of miR-200 were significantly decreased and the levels of ZEB1 were significantly increased in the CRC specimens from patients compared to the paired non-tumor tissue; Moreover the levels of miR-200 and ZEB1 are inversely correlated; Bioinformatics analyses showed that miR-200 targeted the 3'-UTR of ZEB1 mRNA to inhibit its translation which was confirmed by luciferase reporter assay;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;Concomitant with miR-200 decrease there was an increase in ZEB1 mRNA expression; Concomitant with the increase in miR-200b and miR-200c ZEB1 expression was decreased and cells appeared more epithelial in morphology and were sensitized to TAM and fulvestrant inhibition;Nintedanib was able to reverse TGF-β1-induced EMT and resistance to gefitinib caused by miR-200b and miR-141 upregulation and ZEB1 downregulation;MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways cell migration;;;;;tumorigenesis;;;;;;;metastasis;;;drug resistance;metastasis gastric cancer;sarcoma;breast cancer;endometrial cancer;sarcoma;head and neck cancer;bladder cancer;breast cancer;ovarian cancer;ovarian cancer;B cell lymphoma;sarcoma;colorectal cancer;prostate cancer;breast cancer;lung squamous cell cancer;breast cancer hsa-miR-200c-3p ZEB1 -0.413752622631687 8.69363337156544e-06 0.0669596779850563 0.391680686806474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.223253118580762 5.38239549070261e-14 27666124;24710933;23754305;24615544;24424572;24186205;21682933;22407310;27717206;23626803 miR 200c regulates crizotinib resistant ALK positive lung cancer cells by reversing epithelial mesenchymal transition via targeting ZEB1;miR-200c has been shown to regulate the epithelial-mesenchymal transition EMT by inhibiting ZEB1 and ZEB2 expression in breast cancer cells; This study further examined the role of miR-200c in the invasion and metastasis of breast cancer that goes beyond the regulation on ZEB1 and ZEB2 expression;Overexpression of miR-200c in SN12-PM6 and 786-0 cells was concurrent with downregulation of ZEB1 and upregulation of E-cadherin mRNA and protein; Thus our study demonstrated that miR-200c decreases the metastatic ability of renal carcinoma cells by upregulating E-cadherin through ZEB1 and that modulating the expression of miR-200c could influence Akt protein levels;MiR 200c suppresses TGF β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer; MiR-200c which was the most significantly downregulated miRNA in trastuzumab-resistant cells restored trastuzumab sensitivity and suppressed invasion of breast cancer cells by concurrently targeting ZNF217 a transcriptional activator of TGF-β and ZEB1 a known mediator of TGF-β signaling; Given the reported backward inhibition of miR-200c by ZEB1 ZNF217 also exerts a feedback suppression of miR-200c via TGF-β/ZEB1 signaling; Restoration of miR-200c silencing of ZEB1 or ZNF217 or blockade of TGF-β signaling increased trastuzumab sensitivity and suppressed invasiveness of breast cancer cells;Accordingly the enforced expression of miR-200c and mir-141 resulted in a significant upregulation in E-cadherin expression contrary to the significant downregulation in ZEB1 expression in 3 cell lines UTSCC-24A UTSCC-24B and UTSCC-6A cells;Furthermore miR-200c was found to be important in modulating ZEB1 upregulation by ERG;Of this family miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2 mediators of epithelial- mesenchymal transition;miR 200c inhibits invasion and migration in human colon cancer cells SW480/620 by targeting ZEB1; Among those dysregulated microRNAs miR-200c was speculated to inhibit metastasis by targeting ZEB1; Overexpression of miR-200c was concurrent with downregulation of ZEB1 mRNA and protein; Taken together our study demonstrated that miR-200c inhibits metastatic ability by targeting ZEB1 in colon cancer cells SW480/620 and suggested that modulation of miR-200c could serve as therapeutic tool for inhibiting metastasis in colorectal cancer;Epigenetic Silencing of miR 200c in Breast Cancer Is Associated with Aggressiveness and Is Modulated by ZEB1;Concomitant with the increase in miR-200b and miR-200c ZEB1 expression was decreased and cells appeared more epithelial in morphology and were sensitized to TAM and fulvestrant inhibition ;metastasis;;metastasis;drug resistance;;;;metastasis;; lung cancer;breast cancer;kidney renal cell cancer;breast cancer;head and neck cancer;prostate cancer;breast cancer;colon cancer;breast cancer;breast cancer hsa-miR-204-5p ZEB1 0.288588537398083 0.113371226435799 0.0669596779850563 0.391680686806474 MirTarget;miRNATAP -0.172024091981783 1.02562887065993e-31 NA NA NA hsa-miR-23a-3p ZEB1 -0.334693010651073 0.00144448147063592 0.0669596779850563 0.391680686806474 MirTarget;miRNATAP -0.168292202491474 3.01274874477747e-08 NA NA NA hsa-miR-23b-3p ZEB1 -0.0476610245859863 0.630277683372509 0.0669596779850563 0.391680686806474 MirTarget;miRNATAP -0.276440882381189 5.01575504565974e-19 23844063 MicroRNA 23b functions as a tumor suppressor by regulating Zeb1 in bladder cancer; Luciferase reporter assays demonstrated that Zeb1 a crucial regulator of epithelial-to-mesenchymal transition EMT is a direct target of miR-23b in bladder cancer bladder cancer hsa-miR-26b-3p ZEB1 0.0542537787460162 0.480221438573792 0.0669596779850563 0.391680686806474 MirTarget -0.123841098409619 0.00119221829703797 NA NA NA hsa-miR-29a-5p ZEB1 0.0697727833812762 0.350621682973061 0.0669596779850563 0.391680686806474 mirMAP -0.199729204033992 1.97338874768111e-07 NA NA NA hsa-miR-320c ZEB1 -0.343259124189967 0.000248338401291042 0.0669596779850563 0.391680686806474 miRanda -0.102045306031695 0.00100197229928958 NA NA NA hsa-miR-324-5p ZEB1 -0.0183370482495828 0.842996782677376 0.0669596779850563 0.391680686806474 miRanda -0.19404124109879 3.30229052009061e-10 NA NA NA hsa-miR-335-3p ZEB1 -0.345405843355925 0.000438486602223359 0.0669596779850563 0.391680686806474 MirTarget;mirMAP -0.17332269728551 4.21139499591863e-09 NA NA NA hsa-miR-335-5p ZEB1 -0.0938511632756835 0.336889056387767 0.0669596779850563 0.391680686806474 miRNAWalker2_validate -0.109997380409383 0.000193021140611597 NA NA NA hsa-miR-342-3p ZEB1 0.125683829770898 0.105810751640081 0.0669596779850563 0.391680686806474 miRanda;miRNATAP -0.247484428097474 8.81130025242343e-10 NA NA NA hsa-miR-361-5p ZEB1 -0.0107519600643009 0.882230614095884 0.0669596779850563 0.391680686806474 miRanda -0.416569100934553 7.20282789930829e-19 NA NA NA hsa-miR-362-3p ZEB1 -0.032375035235532 0.736465332563774 0.0669596779850563 0.391680686806474 miRanda -0.178875182664928 8.12794182045741e-10 NA NA NA hsa-miR-375 ZEB1 0.0268401141324208 0.858358101444604 0.0669596779850563 0.391680686806474 miRanda -0.157898298057853 3.42237866910407e-18 27270433 A ZEB1 miR 375 YAP1 pathway regulates epithelial plasticity in prostate cancer; Furthermore transcription of the miR-375 gene was shown to be directly repressed by the EMT transcription factor ZEB1 prostate cancer hsa-miR-421 ZEB1 0.171573235029884 0.0518112933650958 0.0669596779850563 0.391680686806474 miRanda -0.150902252896693 2.49187553754282e-06 NA NA NA hsa-miR-452-5p ZEB1 -0.599327068454216 1.02031931068513e-05 0.0669596779850563 0.391680686806474 MirTarget;miRNATAP -0.105489805777652 2.57427414243085e-07 NA NA NA hsa-miR-455-3p ZEB1 -0.51270181640209 0.000459755983280324 0.0669596779850563 0.391680686806474 MirTarget;miRNATAP -0.105536608468494 4.47727506981647e-08 26801503 MicroRNA 455 suppresses non small cell lung cancer through targeting ZEB1; Data from reporter assays showed that miR-455 directly binds to 3'UTR of ZEB1 and suppresses the endogenous level of ZEB1 protein expression; Moreover we found that upregulation of ZEB1 expression is inversely associated with miR-455 expression in NSCLC tissues; Taken together miR-455 as an anti-oncogene in non-small cell lung cancer through up-regulation of ZEB1 and serve as a potential therapeutic target in NSCLC lung squamous cell cancer hsa-miR-532-3p ZEB1 -0.150624483952728 0.0599635132177403 0.0669596779850563 0.391680686806474 miRNATAP -0.157622193630799 1.60772411557604e-05 NA NA NA hsa-miR-543 ZEB1 0.347737549779626 0.0157394585079679 0.0669596779850563 0.391680686806474 miRNATAP -0.102316545446156 2.78699157574118e-07 NA NA NA hsa-miR-576-5p ZEB1 -0.106482276040039 0.194379152564202 0.0669596779850563 0.391680686806474 MirTarget;PITA;mirMAP -0.164581217069458 2.24853753411566e-06 NA NA NA hsa-miR-590-3p ZEB1 -0.312951515438399 0.00048045542384394 0.0669596779850563 0.391680686806474 miRanda -0.210202389664121 1.24691634764046e-11 26556542 miR 590 3p suppresses cancer cell migration invasion and epithelial mesenchymal transition in glioblastoma multiforme by targeting ZEB1 and ZEB2; Bioinformatics coupled with luciferase and Western blot assays also revealed that miR-590-3p inhibited expression of ZEB1 and ZEB2 which are master regulators of tumor metastasis; Our study first indicates that miR-590-3p functions as a suppressor of GBM EMT and metastasis by targeting ZEB1 and ZEB2 and it may be a therapeutic target for metastatic GBM cell migration;metastasis glioblastoma hsa-miR-590-5p ZEB1 -0.169460270359482 0.0386004382081766 0.0669596779850563 0.391680686806474 miRanda -0.211937777465385 8.2433681340962e-10 26556542 miR 590 3p suppresses cancer cell migration invasion and epithelial mesenchymal transition in glioblastoma multiforme by targeting ZEB1 and ZEB2 cell migration glioblastoma hsa-miR-655-3p ZEB1 0.241086974063522 0.0960363954844231 0.0669596779850563 0.391680686806474 MirTarget -0.113892240406054 4.27154349941979e-09 NA NA NA hsa-miR-7-1-3p ZEB1 0.0894475316162513 0.373223597851017 0.0669596779850563 0.391680686806474 MirTarget;mirMAP -0.212967654660225 1.69814967366491e-14 NA NA NA hsa-miR-708-3p ZEB1 -0.00458267260361467 0.962455132950912 0.0669596779850563 0.391680686806474 MirTarget;miRNATAP -0.139669405863414 1.60247441090805e-05 NA NA NA hsa-miR-942-5p ZEB1 -0.331570745524138 0.00475398014468333 0.0669596779850563 0.391680686806474 MirTarget -0.125902360843027 1.96260201587997e-07 NA NA NA hsa-let-7a-3p ZNF217 -0.0530563276543585 0.370749834463726 -0.474105007236816 3.45168745618393e-10 mirMAP -0.188144469292981 0.00229873579047011 NA NA NA hsa-miR-105-5p ZNF217 0.567459149851699 8.20858944634191e-06 -0.474105007236816 3.45168745618393e-10 mirMAP -0.247157170966837 4.82014090309169e-23 NA NA NA hsa-miR-137 ZNF217 0.924849266740897 1.54683220204945e-06 -0.474105007236816 3.45168745618393e-10 MirTarget;PITA;miRanda;miRNATAP -0.130780234000928 9.7696051614795e-16 NA NA NA hsa-miR-139-5p ZNF217 0.647754756897662 2.1537830723695e-06 -0.474105007236816 3.45168745618393e-10 miRanda -0.247351105544404 4.36116593020855e-26 NA NA NA hsa-miR-19b-3p ZNF217 0.013842745084812 0.856506310672867 -0.474105007236816 3.45168745618393e-10 miRNAWalker2_validate;MirTarget -0.121292901351907 0.013022417764512 NA NA NA hsa-miR-20a-5p ZNF217 0.0115865752289119 0.887069448775761 -0.474105007236816 3.45168745618393e-10 MirTarget -0.147632737112848 0.00215659925344293 NA NA NA hsa-miR-338-3p ZNF217 0.399637046793888 0.00344106432206527 -0.474105007236816 3.45168745618393e-10 MirTarget;miRanda -0.168429334382049 6.51295993341302e-11 NA NA NA hsa-miR-582-5p ZNF217 0.215764335500681 0.0760892640434293 -0.474105007236816 3.45168745618393e-10 MirTarget -0.139960417176649 1.13424709336172e-07 NA NA NA hsa-miR-7-1-3p ZNF217 0.0894475316162513 0.373223597851017 -0.474105007236816 3.45168745618393e-10 mirMAP -0.112877928949613 0.000557506761608093 NA NA NA