miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-21-5p AKT2 1.75445050487988 2.41825549682022e-23 -0.0135478038511252 0.922701697200587 miRNAWalker2_validate -0.147206602823392 0.00352458167442573 NA NA NA hsa-miR-29b-3p AKT2 -0.230693226193598 0.367461626035234 -0.0135478038511252 0.922701697200587 MirTarget -0.141689777106604 0.000224365237662475 26512921;26564501;24076586 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3;The expression of miR-29b was significantly upregualted by cisplatin treatmentwhile its target gene AKT2 was downregulated;Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis ;; ovarian cancer;gastric cancer;acute myeloid leukemia hsa-miR-106b-5p AKT3 1.70863907461894 2.04074794107142e-08 -0.748577301508132 0.0693608036068007 miRNATAP -0.368902671357459 6.63579377990938e-05 NA NA NA hsa-miR-107 AKT3 0.904627575346218 4.67936495073904e-05 -0.748577301508132 0.0693608036068007 PITA;miRanda -0.596025797372068 4.38261497597827e-06 NA NA NA hsa-miR-15b-5p AKT3 1.62046407540723 5.42152621571078e-09 -0.748577301508132 0.0693608036068007 miRNATAP -0.359857777182961 0.000407223981183838 NA NA NA hsa-miR-16-5p AKT3 1.00515772948091 5.33912942007619e-06 -0.748577301508132 0.0693608036068007 miRNAWalker2_validate;miRTarBase;miRNATAP -0.473860841884761 0.000305952592817196 NA NA NA hsa-miR-17-3p AKT3 1.31126744284937 3.24768335024185e-07 -0.748577301508132 0.0693608036068007 miRNATAP -0.520864813647553 2.25932722443508e-06 NA NA NA hsa-miR-17-5p AKT3 1.65862087862483 8.45603406215941e-08 -0.748577301508132 0.0693608036068007 TargetScan;miRNATAP -0.276276453758938 0.00270096970703173 NA NA NA hsa-miR-29a-3p AKT3 -0.113012156986374 0.615005009685815 -0.748577301508132 0.0693608036068007 miRNATAP -0.408748871699734 0.00212322174807936 NA NA NA hsa-miR-29b-3p AKT3 -0.230693226193598 0.367461626035234 -0.748577301508132 0.0693608036068007 miRNATAP -0.338134432146425 0.00361456599882575 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-32-3p AKT3 0.583525764322974 0.11837203008551 -0.748577301508132 0.0693608036068007 mirMAP -0.324144417685552 0.000230218736536503 NA NA NA hsa-miR-320b AKT3 1.11183660885284 0.000497971211648503 -0.748577301508132 0.0693608036068007 PITA;miRanda;miRNATAP -0.263235906209639 0.00390234919135454 NA NA NA hsa-miR-335-3p AKT3 2.5197689063267 2.20084506976733e-09 -0.748577301508132 0.0693608036068007 mirMAP -0.224460236877792 0.000742588100170571 NA NA NA hsa-miR-33a-3p AKT3 0.347011402017138 0.321709379745392 -0.748577301508132 0.0693608036068007 mirMAP -0.376513667394311 1.68302152281553e-05 NA NA NA hsa-miR-362-3p AKT3 -0.0349414695893027 0.913780708043777 -0.748577301508132 0.0693608036068007 miRanda -0.37545416085904 3.60412362584734e-05 NA NA NA hsa-miR-362-5p AKT3 -0.354508685915981 0.354912078595613 -0.748577301508132 0.0693608036068007 PITA;TargetScan;miRNATAP -0.231850776707854 0.00252522310690117 NA NA NA hsa-miR-501-3p AKT3 0.731876211669996 0.0270421347018303 -0.748577301508132 0.0693608036068007 miRNATAP -0.389710500003727 8.30408434984544e-06 NA NA NA hsa-miR-502-3p AKT3 -0.16442685491191 0.557471818466728 -0.748577301508132 0.0693608036068007 miRNATAP -0.502835122914366 1.28261107693995e-06 NA NA NA hsa-miR-505-3p AKT3 0.82660100642669 0.00111666333288398 -0.748577301508132 0.0693608036068007 mirMAP -0.351999859841566 0.0023495079245673 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-548v AKT3 -0.156004387355895 0.708665170641638 -0.748577301508132 0.0693608036068007 miRNATAP -0.26608196493585 0.000310856014668821 NA NA NA hsa-miR-577 AKT3 0.911619788986754 0.2256062124148 -0.748577301508132 0.0693608036068007 mirMAP -0.230357457399908 2.14832389488646e-09 NA NA NA hsa-miR-616-5p AKT3 0.834052908652744 0.0347835664029363 -0.748577301508132 0.0693608036068007 mirMAP -0.265580906698402 0.000411824587413266 NA NA NA hsa-let-7b-5p BCL2L1 0.0582902155815681 0.781400138984745 0.213751739166448 0.395782450784369 miRNATAP -0.314285217081765 0.000268924662830079 26915294;20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA poor survival; lung cancer;liver cancer hsa-let-7c-5p BCL2L1 -0.503482361446512 0.206848395212976 0.213751739166448 0.395782450784369 miRNAWalker2_validate;miRTarBase -0.198493465039984 6.59628301755695e-06 20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA liver cancer hsa-miR-149-5p BCL2L1 0.706277554734069 0.296848731347677 0.213751739166448 0.395782450784369 mirMAP -0.173000301400021 4.12180118165392e-12 NA NA NA hsa-miR-214-3p BCL2L1 1.01201534142544 0.00625092909225755 0.213751739166448 0.395782450784369 mirMAP -0.12678075713813 0.00823737366000966 NA NA NA hsa-miR-23b-3p BCL2L1 -0.286465516491361 0.18664668472995 0.213751739166448 0.395782450784369 miRNAWalker2_validate -0.389042865664013 2.23464331013867e-06 NA NA NA hsa-let-7a-3p CBL 0.503048155002889 0.0411145454335299 0.0598102927467332 0.736690252077759 MirTarget -0.136961025961691 0.00775223213066374 NA NA NA hsa-let-7b-3p CBL 0.21838629112113 0.296038413622566 0.0598102927467332 0.736690252077759 MirTarget -0.184248447431121 0.00260394407707869 NA NA NA hsa-let-7b-5p CBL 0.0582902155815681 0.781400138984745 0.0598102927467332 0.736690252077759 MirTarget -0.217431440586868 0.000336982839929213 NA NA NA hsa-miR-664a-3p CBL -0.83041219170254 0.000136267547251167 0.0598102927467332 0.736690252077759 mirMAP -0.184062668996938 0.00136851964174968 NA NA NA hsa-miR-330-3p CBLB 0.798460296022179 0.00746538156533435 0.20302895171513 0.344241284018733 PITA;mirMAP -0.134946817780209 0.00804296944689662 NA NA NA hsa-miR-338-3p CCND1 -0.959276231066179 0.0191473351014091 0.62464034212269 0.131198685408586 miRNAWalker2_validate;miRTarBase;miRanda -0.237799286777961 0.000859583563159798 NA NA NA hsa-let-7a-3p CCND2 0.503048155002889 0.0411145454335299 -0.495732246530821 0.299995013548082 mirMAP -0.539007488034469 9.58303749078928e-05 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7b-3p CCND2 0.21838629112113 0.296038413622566 -0.495732246530821 0.299995013548082 mirMAP -0.458425126620734 0.00587678366196967 NA NA NA hsa-miR-106b-5p CCND2 1.70863907461894 2.04074794107142e-08 -0.495732246530821 0.299995013548082 miRNAWalker2_validate;miRTarBase;miRNATAP -0.420111135029172 8.79445971678554e-05 NA NA NA hsa-miR-130b-5p CCND2 0.701350393759937 0.0510142718395002 -0.495732246530821 0.299995013548082 mirMAP -0.393986053261913 2.48361314637284e-05 NA NA NA hsa-miR-141-3p CCND2 1.45548825076434 0.00115958850961764 -0.495732246530821 0.299995013548082 MirTarget;TargetScan -0.213829265059233 0.00435932519246045 NA NA NA hsa-miR-15b-5p CCND2 1.62046407540723 5.42152621571078e-09 -0.495732246530821 0.299995013548082 miRNATAP -0.436574112059407 0.000206222006606723 NA NA NA hsa-miR-16-2-3p CCND2 1.8048179609245 2.83095715136409e-09 -0.495732246530821 0.299995013548082 mirMAP -0.54923627359894 1.83952504317926e-07 NA NA NA hsa-miR-16-5p CCND2 1.00515772948091 5.33912942007619e-06 -0.495732246530821 0.299995013548082 miRNAWalker2_validate;miRNATAP -0.666404634405191 9.74095569654959e-06 NA NA NA hsa-miR-181a-2-3p CCND2 0.901732254836667 0.000830304681396734 -0.495732246530821 0.299995013548082 mirMAP -0.381747755391939 0.00236274066260059 NA NA NA hsa-miR-182-5p CCND2 0.887369486030646 0.0310640781418789 -0.495732246530821 0.299995013548082 miRNAWalker2_validate;miRTarBase;miRNATAP -0.320494097434122 8.56279904949731e-05 NA NA NA hsa-miR-183-5p CCND2 1.65900927871187 0.000522025364980187 -0.495732246530821 0.299995013548082 miRNATAP -0.293018901580787 2.29962975856133e-05 NA NA NA hsa-miR-19b-3p CCND2 0.759818275708988 0.00652779573186786 -0.495732246530821 0.299995013548082 miRNAWalker2_validate;MirTarget;miRNATAP -0.321137891620492 0.0085283453454723 NA NA NA hsa-miR-21-3p CCND2 1.75245546017565 2.36505176715025e-10 -0.495732246530821 0.299995013548082 mirMAP -0.330852598235875 0.00510140773909108 NA NA NA hsa-miR-224-3p CCND2 1.52422171450716 0.00650463542340912 -0.495732246530821 0.299995013548082 mirMAP -0.268591207673576 3.7771965471366e-05 NA NA NA hsa-miR-26b-5p CCND2 -0.301646326928219 0.160081421968103 -0.495732246530821 0.299995013548082 mirMAP;miRNATAP -0.575426727790569 0.00033543015515606 NA NA NA hsa-miR-301a-3p CCND2 1.44721900431161 6.35068481036652e-06 -0.495732246530821 0.299995013548082 miRNAWalker2_validate -0.383757128016972 0.0002041077399091 NA NA NA hsa-miR-3065-3p CCND2 -1.03551124329864 0.0218397494946288 -0.495732246530821 0.299995013548082 MirTarget;miRNATAP -0.202763155868079 0.00685463393219998 NA NA NA hsa-miR-3065-5p CCND2 -0.241623656423063 0.633116553078159 -0.495732246530821 0.299995013548082 mirMAP -0.236172852888811 0.000570437819651464 NA NA NA hsa-miR-424-5p CCND2 1.08509868581983 0.000420473853818268 -0.495732246530821 0.299995013548082 miRNATAP -0.393741408465626 0.000302491529945387 NA NA NA hsa-miR-429 CCND2 1.40182602301928 0.00900426780286475 -0.495732246530821 0.299995013548082 miRNATAP -0.193697975832347 0.00200087926732012 NA NA NA hsa-miR-450b-5p CCND2 0.46157963033014 0.13273722727895 -0.495732246530821 0.299995013548082 MirTarget;PITA;miRNATAP -0.319300360536976 0.00413356428949538 NA NA NA hsa-miR-590-3p CCND2 1.11654983899947 0.000160782154924864 -0.495732246530821 0.299995013548082 miRanda;mirMAP -0.332566390160307 0.00348233876262983 NA NA NA hsa-miR-590-5p CCND2 1.04171442093217 0.000272475544954865 -0.495732246530821 0.299995013548082 mirMAP -0.40586994965179 0.000547583893303904 NA NA NA hsa-miR-9-3p CCND2 0.330346058941473 0.541111939982661 -0.495732246530821 0.299995013548082 MirTarget;mirMAP;miRNATAP -0.190791407012111 0.00360684983294818 NA NA NA hsa-miR-93-5p CCND2 1.7515174434778 1.59386482413883e-08 -0.495732246530821 0.299995013548082 miRNATAP -0.321341054229317 0.00244079386586045 NA NA NA hsa-miR-96-5p CCND2 1.14243043653372 0.00942969392739105 -0.495732246530821 0.299995013548082 TargetScan;miRNATAP -0.334672732851839 2.58915737933556e-05 NA NA NA hsa-miR-96-5p CCND3 1.14243043653372 0.00942969392739105 0.0356607593991125 0.883520357560836 TargetScan -0.119818202566509 0.00327749541512401 NA NA NA hsa-miR-214-5p CISH 1.03136265998195 0.00140640252296399 -0.735409268246199 0.000683517189861248 miRNATAP -0.135925521651641 0.0044462952458416 NA NA NA hsa-miR-24-3p CISH 1.08578167539644 6.18549359075268e-07 -0.735409268246199 0.000683517189861248 MirTarget -0.264016723820104 0.000158950941208271 NA NA NA hsa-miR-324-5p CISH 1.08820215809537 3.11674414561836e-05 -0.735409268246199 0.000683517189861248 miRanda -0.199559921746164 0.000661113084862126 NA NA NA hsa-miR-374a-3p CISH 0.0420912023953779 0.851478041312794 -0.735409268246199 0.000683517189861248 MirTarget -0.206487807882282 0.00334473658551082 NA NA NA hsa-miR-429 CLCF1 1.40182602301928 0.00900426780286475 0.0593647525409939 0.865480230541533 miRanda;miRNATAP -0.120052503993581 0.00901957393729673 NA NA NA hsa-miR-491-5p CLCF1 -0.693578126269305 0.0313646742330058 0.0593647525409939 0.865480230541533 miRanda -0.223172913347312 0.00470948791414157 NA NA NA hsa-miR-19a-3p CNTFR 1.26669687448473 0.000105972838514412 -3.86674325526022 1.6096558994221e-05 miRNATAP -0.513593965222605 0.00931712849822324 NA NA NA hsa-miR-200b-3p CNTFR 0.974577911407732 0.0595020056914543 -3.86674325526022 1.6096558994221e-05 TargetScan -0.378928880542303 0.00251950370660475 NA NA NA hsa-miR-21-5p CNTFR 1.75445050487988 2.41825549682022e-23 -3.86674325526022 1.6096558994221e-05 miRNATAP -1.41717911738816 2.04333706523782e-05 NA NA NA hsa-miR-429 CNTFR 1.40182602301928 0.00900426780286475 -3.86674325526022 1.6096558994221e-05 PITA;miRanda;miRNATAP -0.405003141819754 0.000736136898393768 NA NA NA hsa-miR-186-5p CREBBP 0.149964130725901 0.434709542998771 -0.106993896504943 0.454357945668245 mirMAP;miRNATAP -0.143307553733926 0.0076774519745605 NA NA NA hsa-miR-429 CSF2RA 1.40182602301928 0.00900426780286475 1.26155664464691 0.00319508155753303 miRanda -0.177464361737511 0.00171248571778422 NA NA NA hsa-miR-15b-3p CSF2RB 1.75738933306437 3.00554466232543e-08 -0.200137813184114 0.596568526131504 mirMAP -0.312420406243405 0.000120694089204471 NA NA NA hsa-miR-30b-3p CSF2RB -0.266398938200332 0.400847813143994 -0.200137813184114 0.596568526131504 MirTarget -0.245556903717171 0.003931259065523 NA NA NA hsa-miR-452-3p CSF2RB 2.2028815467959 0.00185370432491004 -0.200137813184114 0.596568526131504 mirMAP -0.133306575465583 0.0015572310697747 NA NA NA hsa-miR-940 CSF3R 1.64406174271686 0.000690854900107004 0.652060868547026 0.176599635952907 MirTarget -0.249751964597886 0.00250861179113934 NA NA NA hsa-miR-185-5p CTF1 1.14351510556643 1.07346945085714e-08 -1.121819613163 0.0165454720208741 MirTarget -0.448487171885351 0.00646476039142382 NA NA NA hsa-miR-590-3p CTF1 1.11654983899947 0.000160782154924864 -1.121819613163 0.0165454720208741 miRanda -0.429980573345921 0.000109328349713906 NA NA NA hsa-miR-106b-5p EP300 1.70863907461894 2.04074794107142e-08 0.0301764271351921 0.833038220279424 miRNATAP -0.100179986132884 0.00163708231399858 NA NA NA hsa-miR-212-3p EP300 0.960352937108106 0.00133449812322732 0.0301764271351921 0.833038220279424 MirTarget;miRNATAP -0.119462144893836 0.000325617297555144 NA NA NA hsa-miR-26a-5p EP300 -0.384110714440647 0.0442498636014044 0.0301764271351921 0.833038220279424 miRNATAP -0.189916321506519 0.000381014097443189 NA NA NA hsa-miR-26b-5p EP300 -0.301646326928219 0.160081421968103 0.0301764271351921 0.833038220279424 miRNAWalker2_validate;miRNATAP -0.141211197444202 0.00298659835807985 NA NA NA hsa-miR-326 EPO -0.429748586406214 0.2629894124021 0.927575834727 0.193658270560895 miRanda -0.493138948696525 0.000212141785251677 NA NA NA hsa-miR-338-3p EPO -0.959276231066179 0.0191473351014091 0.927575834727 0.193658270560895 miRanda -0.648685939232671 6.94489897307612e-08 NA NA NA hsa-miR-362-3p EPO -0.0349414695893027 0.913780708043777 0.927575834727 0.193658270560895 miRanda -0.592181368877243 0.000174734758673846 NA NA NA hsa-let-7g-5p GHR 0.325297685027927 0.241142963826631 -2.83614122468118 2.56011796824058e-06 miRNATAP -0.444885482782847 0.00552639828995174 NA NA NA hsa-miR-126-5p GHR 0.41765430251855 0.0753161203651532 -2.83614122468118 2.56011796824058e-06 MirTarget;mirMAP -0.525310623057796 0.00575916170779591 NA NA NA hsa-miR-142-3p GHR 1.32364054836498 0.0001537753622128 -2.83614122468118 2.56011796824058e-06 MirTarget;PITA;miRanda;miRNATAP -0.322873877777482 0.00955367274486855 NA NA NA hsa-miR-15a-5p GHR 1.03783090449383 7.40334108980898e-07 -2.83614122468118 2.56011796824058e-06 MirTarget;miRNATAP -0.718884560748438 0.00052069316192807 NA NA NA hsa-miR-15b-5p GHR 1.62046407540723 5.42152621571078e-09 -2.83614122468118 2.56011796824058e-06 MirTarget;miRNATAP -0.529274291413705 0.000530727722860748 NA NA NA hsa-miR-16-2-3p GHR 1.8048179609245 2.83095715136409e-09 -2.83614122468118 2.56011796824058e-06 mirMAP -0.458746467394034 0.000993883987590111 NA NA NA hsa-miR-16-5p GHR 1.00515772948091 5.33912942007619e-06 -2.83614122468118 2.56011796824058e-06 MirTarget;miRNATAP -0.698056825924518 0.000394376718044677 NA NA NA hsa-miR-29a-5p GHR 0.585084040404152 0.023014129158495 -2.83614122468118 2.56011796824058e-06 mirMAP;miRNATAP -0.973713867459453 5.2518717619226e-09 NA NA NA hsa-miR-338-5p GHR -1.19659203838734 0.0100316010080496 -2.83614122468118 2.56011796824058e-06 PITA -0.473026572446891 2.66744291668657e-07 NA NA NA hsa-miR-421 GHR 1.80720854070385 1.59709651202848e-07 -2.83614122468118 2.56011796824058e-06 miRanda -0.405372661550727 0.00104463368043836 NA NA NA hsa-miR-429 GHR 1.40182602301928 0.00900426780286475 -2.83614122468118 2.56011796824058e-06 miRanda;miRNATAP -0.371251650813614 3.44980741686856e-06 NA NA NA hsa-miR-624-5p GHR 1.03467956701702 0.0010908013402586 -2.83614122468118 2.56011796824058e-06 MirTarget -0.384262764917071 0.00872966743561295 NA NA NA hsa-miR-7-1-3p GHR 0.709309110750947 0.0412301737463194 -2.83614122468118 2.56011796824058e-06 MirTarget;mirMAP -0.746505847723966 9.96486525090052e-10 NA NA NA hsa-miR-17-3p IFNAR1 1.31126744284937 3.24768335024185e-07 -0.539209866274569 0.000275139740559387 mirMAP -0.15375232755934 0.000123114047873166 NA NA NA hsa-miR-320b IFNAR1 1.11183660885284 0.000497971211648503 -0.539209866274569 0.000275139740559387 mirMAP -0.116734552782754 0.000349580201541442 NA NA NA hsa-miR-361-5p IFNAR1 0.407725414130987 0.0181260969156347 -0.539209866274569 0.000275139740559387 miRanda -0.236826053405391 0.000154843793731808 NA NA NA hsa-miR-3913-5p IFNAR1 0.878857760706319 0.00310224428304055 -0.539209866274569 0.000275139740559387 mirMAP -0.10836636054715 0.00236936913498482 NA NA NA hsa-miR-452-5p IFNAR1 2.08756506185889 0.000258095769002813 -0.539209866274569 0.000275139740559387 mirMAP -0.107349586469772 8.92454492751194e-10 NA NA NA hsa-miR-484 IFNAR1 0.71327898984355 0.00233605130771196 -0.539209866274569 0.000275139740559387 miRNATAP -0.143880077283194 0.00147602394264695 NA NA NA hsa-miR-1271-5p IFNAR2 1.15538250415776 0.00207865862606828 0.463466879196117 0.014289019910094 mirMAP -0.147733144694323 3.31540499636322e-05 NA NA NA hsa-miR-224-3p IFNAR2 1.52422171450716 0.00650463542340912 0.463466879196117 0.014289019910094 mirMAP -0.144133338906927 1.15224442570249e-08 NA NA NA hsa-miR-129-5p IFNGR1 -2.56914016541176 2.36237896095709e-06 0.647308564814974 0.00244892769088632 miRanda -0.114064722654608 3.23310949615299e-05 NA NA NA hsa-miR-330-5p IL11RA 0.488365986827708 0.0512207630808233 -1.57815181724942 4.49019742754034e-07 miRanda -0.292318222700584 0.0014980251066399 NA NA NA hsa-miR-338-3p IL12RB2 -0.959276231066179 0.0191473351014091 1.56097481647182 0.0221718198368824 miRanda -0.536468670662542 4.30789212350361e-06 NA NA NA hsa-miR-625-5p IL12RB2 0.537211086526376 0.203801009380384 1.56097481647182 0.0221718198368824 miRNAWalker2_validate -0.544495591233906 1.76783993644986e-06 NA NA NA hsa-miR-7-5p IL12RB2 1.63575693499363 0.0124424214624534 1.56097481647182 0.0221718198368824 miRNAWalker2_validate -0.228514279979032 0.0031679610832289 NA NA NA hsa-miR-128-3p IL13RA1 0.98280381420517 5.77641850797209e-05 -0.0905799030289263 0.656843849810583 MirTarget -0.198150217770521 0.000680189134084939 NA NA NA hsa-miR-16-2-3p IL13RA1 1.8048179609245 2.83095715136409e-09 -0.0905799030289263 0.656843849810583 MirTarget -0.168025554347203 0.000211398348745259 NA NA NA hsa-miR-181a-2-3p IL13RA1 0.901732254836667 0.000830304681396734 -0.0905799030289263 0.656843849810583 MirTarget -0.147553373956792 0.00559059567661001 NA NA NA hsa-miR-22-3p IL13RA1 0.0312103895892015 0.845091185648687 -0.0905799030289263 0.656843849810583 MirTarget;miRNATAP -0.25023219970581 0.00794888256305368 NA NA NA hsa-miR-224-3p IL13RA1 1.52422171450716 0.00650463542340912 -0.0905799030289263 0.656843849810583 MirTarget -0.116983756384067 2.17619566727128e-05 NA NA NA hsa-miR-324-5p IL13RA1 1.08820215809537 3.11674414561836e-05 -0.0905799030289263 0.656843849810583 miRanda -0.18888168571694 0.000503370277723777 NA NA NA hsa-miR-331-3p IL13RA1 1.04880525429426 9.99995355989124e-05 -0.0905799030289263 0.656843849810583 MirTarget -0.159308757811114 0.00261239335258188 NA NA NA hsa-miR-590-3p IL13RA1 1.11654983899947 0.000160782154924864 -0.0905799030289263 0.656843849810583 miRanda;mirMAP -0.132827216704544 0.00589582545135983 NA NA NA hsa-miR-129-5p IL15 -2.56914016541176 2.36237896095709e-06 0.561205086043478 0.114361741556834 miRanda -0.129626089860845 0.00483201901929051 NA NA NA hsa-miR-429 IL15 1.40182602301928 0.00900426780286475 0.561205086043478 0.114361741556834 miRanda -0.128722570816782 0.0058829595323254 NA NA NA hsa-miR-199b-5p IL15RA 0.124595928096068 0.678156859366405 0.745806663263525 0.00549904881955642 miRanda -0.177164581036248 0.00608438447075489 NA NA NA hsa-miR-107 IL20 0.904627575346218 4.67936495073904e-05 2.15431347753676 0.0113046844172621 miRanda -1.07199785435871 7.67416680139114e-05 NA NA NA hsa-miR-125a-5p IL22RA1 -0.878090699011564 0.000213630844319685 1.7920801349447 0.000314724083314029 miRanda -0.456218998920921 0.00252787711546852 NA NA NA hsa-miR-3065-3p IL2RA -1.03551124329864 0.0218397494946288 1.58636868885666 0.000898191400982656 MirTarget -0.304552754458665 4.86138250740433e-05 NA NA NA hsa-miR-375 IL2RA -2.94506033785642 0.00570147601654791 1.58636868885666 0.000898191400982656 miRanda -0.111470623759755 0.000438056598449831 NA NA NA hsa-miR-30b-3p IL2RB -0.266398938200332 0.400847813143994 1.38910197190606 0.000401856674821465 mirMAP -0.250810642439919 0.00526393068965205 NA NA NA hsa-miR-429 IL4R 1.40182602301928 0.00900426780286475 0.0040751665408143 0.986450236759292 miRNATAP -0.126339838670445 4.58833941906607e-05 NA NA NA hsa-miR-335-5p IL6 1.59953351087307 5.56170899867314e-05 -0.231605470294641 0.731469898867652 miRNAWalker2_validate -0.506635073744166 1.52521264215909e-05 NA NA NA hsa-miR-429 IL6 1.40182602301928 0.00900426780286475 -0.231605470294641 0.731469898867652 miRanda -0.444331362467888 2.80787806769216e-07 NA NA NA hsa-miR-106b-5p IL6R 1.70863907461894 2.04074794107142e-08 -0.905212913572453 0.00926947429038247 mirMAP -0.375064159148522 1.3455709733343e-06 NA NA NA hsa-miR-130b-3p IL6R 1.32714007211004 4.78676252285191e-05 -0.905212913572453 0.00926947429038247 mirMAP -0.252615757241476 0.000736777168802262 NA NA NA hsa-miR-135b-5p IL6R 4.09156383496059 1.32294295002438e-12 -0.905212913572453 0.00926947429038247 mirMAP -0.151344803673925 0.000164682685389657 NA NA NA hsa-miR-17-5p IL6R 1.65862087862483 8.45603406215941e-08 -0.905212913572453 0.00926947429038247 mirMAP -0.292216234222658 0.00016291526717577 NA NA NA hsa-miR-182-5p IL6R 0.887369486030646 0.0310640781418789 -0.905212913572453 0.00926947429038247 mirMAP -0.180178637117133 0.00276791054483128 NA NA NA hsa-miR-197-3p IL6R 0.888854270009261 0.000195183808214449 -0.905212913572453 0.00926947429038247 MirTarget -0.304801523529987 0.00340841643809556 NA NA NA hsa-miR-20a-5p IL6R 1.4503375861709 5.7813456424762e-07 -0.905212913572453 0.00926947429038247 mirMAP -0.277969071029928 0.000879001937726358 NA NA NA hsa-miR-320b IL6R 1.11183660885284 0.000497971211648503 -0.905212913572453 0.00926947429038247 miRanda;miRNATAP -0.26071612670564 0.000705010911972535 NA NA NA hsa-miR-320c IL6R 0.455072851945474 0.240613785444485 -0.905212913572453 0.00926947429038247 miRanda;miRNATAP -0.26551655079458 0.000337334599422536 NA NA NA hsa-miR-335-5p IL6R 1.59953351087307 5.56170899867314e-05 -0.905212913572453 0.00926947429038247 mirMAP -0.23527720833989 0.00011763154993372 NA NA NA hsa-miR-484 IL6R 0.71327898984355 0.00233605130771196 -0.905212913572453 0.00926947429038247 MirTarget -0.277530642524318 0.0094684399027223 NA NA NA hsa-miR-93-5p IL6R 1.7515174434778 1.59386482413883e-08 -0.905212913572453 0.00926947429038247 mirMAP -0.281989462839872 0.000258843056158441 NA NA NA hsa-let-7a-3p IL6ST 0.503048155002889 0.0411145454335299 -1.42544168448467 4.65520066332643e-06 mirMAP -0.246786497938286 0.00799497201909779 NA NA NA hsa-let-7f-1-3p IL6ST 1.28704406797397 1.17954701106157e-06 -1.42544168448467 4.65520066332643e-06 mirMAP -0.360394462617376 1.36992621426634e-05 NA NA NA hsa-miR-103a-3p IL6ST 0.840525139266028 5.83536475789158e-07 -1.42544168448467 4.65520066332643e-06 mirMAP -0.673347149160237 3.60843082030333e-07 NA NA NA hsa-miR-1301-3p IL6ST 1.59017279464031 4.6624715470094e-06 -1.42544168448467 4.65520066332643e-06 MirTarget -0.285031393357855 5.79613196646344e-06 NA NA NA hsa-miR-130b-3p IL6ST 1.32714007211004 4.78676252285191e-05 -1.42544168448467 4.65520066332643e-06 miRNATAP -0.385879385584722 5.59740893547979e-09 NA NA NA hsa-miR-135b-5p IL6ST 4.09156383496059 1.32294295002438e-12 -1.42544168448467 4.65520066332643e-06 mirMAP -0.114894514124885 0.00178589267480037 NA NA NA hsa-miR-148b-3p IL6ST 0.295175884456199 0.17466422420702 -1.42544168448467 4.65520066332643e-06 MirTarget -0.283578934026422 0.00763874478416595 NA NA NA hsa-miR-148b-5p IL6ST 1.04409494910362 0.00195860954157389 -1.42544168448467 4.65520066332643e-06 mirMAP -0.199521548949371 0.00278321248085818 NA NA NA hsa-miR-16-1-3p IL6ST 1.43227522002564 3.70920454953168e-08 -1.42544168448467 4.65520066332643e-06 mirMAP -0.26626103043367 0.00166150754950024 NA NA NA hsa-miR-16-2-3p IL6ST 1.8048179609245 2.83095715136409e-09 -1.42544168448467 4.65520066332643e-06 mirMAP -0.307668065654789 1.44172175126915e-05 NA NA NA hsa-miR-17-5p IL6ST 1.65862087862483 8.45603406215941e-08 -1.42544168448467 4.65520066332643e-06 TargetScan -0.424465189088693 5.51762680507727e-10 NA NA NA hsa-miR-181b-5p IL6ST 1.64216500592669 1.89228845300725e-08 -1.42544168448467 4.65520066332643e-06 mirMAP -0.196427379902317 0.00912583037693832 NA NA NA hsa-miR-182-5p IL6ST 0.887369486030646 0.0310640781418789 -1.42544168448467 4.65520066332643e-06 mirMAP -0.336865519005568 1.55556625200791e-10 NA NA NA hsa-miR-19a-3p IL6ST 1.26669687448473 0.000105972838514412 -1.42544168448467 4.65520066332643e-06 mirMAP;miRNATAP -0.27413679495985 5.21822422863793e-05 NA NA NA hsa-miR-19b-3p IL6ST 0.759818275708988 0.00652779573186786 -1.42544168448467 4.65520066332643e-06 mirMAP;miRNATAP -0.311773885474519 0.000107753979699173 NA NA NA hsa-miR-200a-5p IL6ST 1.50371809098978 0.00263602434344863 -1.42544168448467 4.65520066332643e-06 mirMAP -0.141851546586691 0.00150817099954074 NA NA NA hsa-miR-200b-3p IL6ST 0.974577911407732 0.0595020056914543 -1.42544168448467 4.65520066332643e-06 TargetScan;mirMAP -0.124425360773427 0.0043387980574345 NA NA NA hsa-miR-200b-5p IL6ST 0.969871521250413 0.0530500454130183 -1.42544168448467 4.65520066332643e-06 mirMAP -0.152660038744588 0.00118153611724549 NA NA NA hsa-miR-200c-3p IL6ST 1.28185685499076 0.00369777635539177 -1.42544168448467 4.65520066332643e-06 mirMAP -0.223901300072699 7.80930998114379e-06 NA NA NA hsa-miR-20a-3p IL6ST 1.13957127410163 0.000451087640268489 -1.42544168448467 4.65520066332643e-06 mirMAP -0.398586527616203 2.36164941448604e-09 NA NA NA hsa-miR-21-5p IL6ST 1.75445050487988 2.41825549682022e-23 -1.42544168448467 4.65520066332643e-06 mirMAP -0.348219421182764 0.00290030494465317 NA NA NA hsa-miR-219a-1-3p IL6ST 1.25987698719907 0.000462608426981798 -1.42544168448467 4.65520066332643e-06 MirTarget -0.289244884761965 2.41317860297988e-06 NA NA NA hsa-miR-23a-3p IL6ST 1.10685926969665 3.16223452471768e-08 -1.42544168448467 4.65520066332643e-06 MirTarget -0.491435236940612 7.79403147714146e-06 NA NA NA hsa-miR-24-2-5p IL6ST 1.24948624677556 6.95051249640114e-07 -1.42544168448467 4.65520066332643e-06 MirTarget -0.253107408061947 0.00420873036625996 NA NA NA hsa-miR-301a-3p IL6ST 1.44721900431161 6.35068481036652e-06 -1.42544168448467 4.65520066332643e-06 mirMAP;miRNATAP -0.293428835145758 1.81347113937832e-05 NA NA NA hsa-miR-3065-5p IL6ST -0.241623656423063 0.633116553078159 -1.42544168448467 4.65520066332643e-06 mirMAP;miRNATAP -0.162410721007028 0.000371945800949872 NA NA NA hsa-miR-32-3p IL6ST 0.583525764322974 0.11837203008551 -1.42544168448467 4.65520066332643e-06 mirMAP -0.216476080645115 0.0014995240525345 NA NA NA hsa-miR-330-3p IL6ST 0.798460296022179 0.00746538156533435 -1.42544168448467 4.65520066332643e-06 PITA;mirMAP -0.288251978708376 0.00012836260608 NA NA NA hsa-miR-335-3p IL6ST 2.5197689063267 2.20084506976733e-09 -1.42544168448467 4.65520066332643e-06 MirTarget;mirMAP -0.298610537175903 1.93051455179044e-09 NA NA NA hsa-miR-335-5p IL6ST 1.59953351087307 5.56170899867314e-05 -1.42544168448467 4.65520066332643e-06 miRNAWalker2_validate -0.182714429149814 0.00108615826837178 NA NA NA hsa-miR-33a-3p IL6ST 0.347011402017138 0.321709379745392 -1.42544168448467 4.65520066332643e-06 mirMAP -0.235090214722122 0.000552147444366296 NA NA NA hsa-miR-33a-5p IL6ST 0.407757858040717 0.321429014317207 -1.42544168448467 4.65520066332643e-06 mirMAP -0.323021255490378 1.25948919500206e-09 NA NA NA hsa-miR-33b-5p IL6ST 0.267227362818466 0.614814331176942 -1.42544168448467 4.65520066332643e-06 mirMAP -0.225574159859378 3.64601074181488e-05 NA NA NA hsa-miR-361-5p IL6ST 0.407725414130987 0.0181260969156347 -1.42544168448467 4.65520066332643e-06 mirMAP -0.468029431201818 0.000502320668793288 NA NA NA hsa-miR-3682-3p IL6ST 1.96838261925327 4.94885331227292e-06 -1.42544168448467 4.65520066332643e-06 mirMAP -0.256937101871652 2.02205051178002e-05 NA NA NA hsa-miR-374b-3p IL6ST 0.999491658196932 0.00126937019814872 -1.42544168448467 4.65520066332643e-06 MirTarget -0.301973968263909 7.73146317564671e-05 NA NA NA hsa-miR-421 IL6ST 1.80720854070385 1.59709651202848e-07 -1.42544168448467 4.65520066332643e-06 PITA;miRanda;mirMAP -0.247338909008897 9.15148252342548e-05 NA NA NA hsa-miR-429 IL6ST 1.40182602301928 0.00900426780286475 -1.42544168448467 4.65520066332643e-06 PITA;miRanda;mirMAP;miRNATAP -0.174604885763394 2.38881927023426e-05 NA NA NA hsa-miR-452-5p IL6ST 2.08756506185889 0.000258095769002813 -1.42544168448467 4.65520066332643e-06 mirMAP -0.141378175089139 0.000259958846704105 NA NA NA hsa-miR-455-5p IL6ST 1.20462751989145 6.74386011867484e-05 -1.42544168448467 4.65520066332643e-06 miRanda -0.254236645318712 0.000563869452801197 NA NA NA hsa-miR-505-3p IL6ST 0.82660100642669 0.00111666333288398 -1.42544168448467 4.65520066332643e-06 MirTarget -0.322874974530502 0.000276858500777531 NA NA NA hsa-miR-576-5p IL6ST 0.625714137488957 0.0417100301848969 -1.42544168448467 4.65520066332643e-06 mirMAP -0.249518279287547 0.000703332590038283 NA NA NA hsa-miR-584-5p IL6ST 1.68234626630933 0.000166828539264215 -1.42544168448467 4.65520066332643e-06 mirMAP -0.14045299041409 0.00487515246153225 NA NA NA hsa-miR-590-3p IL6ST 1.11654983899947 0.000160782154924864 -1.42544168448467 4.65520066332643e-06 miRNAWalker2_validate;miRanda;mirMAP;miRNATAP -0.310888497170962 3.40611153248644e-05 NA NA NA hsa-miR-590-5p IL6ST 1.04171442093217 0.000272475544954865 -1.42544168448467 4.65520066332643e-06 mirMAP -0.438958380048037 8.21584096676338e-09 NA NA NA hsa-miR-615-3p IL6ST 2.82967143704683 3.05118423223543e-05 -1.42544168448467 4.65520066332643e-06 miRNAWalker2_validate -0.187388590083962 2.95062077949878e-05 NA NA NA hsa-miR-629-3p IL6ST 1.40326397107309 9.7803063526732e-05 -1.42544168448467 4.65520066332643e-06 miRNATAP -0.280593835681601 4.17944174521401e-06 NA NA NA hsa-miR-9-3p IL6ST 0.330346058941473 0.541111939982661 -1.42544168448467 4.65520066332643e-06 mirMAP;miRNATAP -0.147483170932417 0.000699710651065865 NA NA NA hsa-miR-93-3p IL6ST 1.88964231421793 1.80075645722786e-08 -1.42544168448467 4.65520066332643e-06 MirTarget -0.308188429272094 1.46696081132709e-06 NA NA NA hsa-miR-944 IL7 3.33123095809751 0.0177835044930391 0.773846525192666 0.0749239642197382 mirMAP -0.154079848373053 7.20062603683124e-10 NA NA NA hsa-miR-335-3p IL7R 2.5197689063267 2.20084506976733e-09 0.504021298531021 0.285852618610604 mirMAP -0.24291413782531 0.00142773183477774 NA NA NA hsa-miR-106a-5p JAK1 -0.173255688252641 0.642872703263671 -0.136842202385446 0.389827921807066 MirTarget -0.101846610542039 0.000666717753075567 NA NA NA hsa-miR-106b-5p JAK1 1.70863907461894 2.04074794107142e-08 -0.136842202385446 0.389827921807066 miRNAWalker2_validate;MirTarget -0.110290079275673 0.00189679247366163 NA NA NA hsa-miR-128-3p JAK1 0.98280381420517 5.77641850797209e-05 -0.136842202385446 0.389827921807066 miRNAWalker2_validate -0.167478175907375 0.000212094943900306 NA NA NA hsa-miR-15b-5p JAK1 1.62046407540723 5.42152621571078e-09 -0.136842202385446 0.389827921807066 miRNAWalker2_validate -0.190253406445669 6.18524170361677e-07 NA NA NA hsa-miR-17-5p JAK1 1.65862087862483 8.45603406215941e-08 -0.136842202385446 0.389827921807066 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.117925701047491 0.000746095407405163 NA NA NA hsa-miR-23b-3p JAK1 -0.286465516491361 0.18664668472995 -0.136842202385446 0.389827921807066 miRNAWalker2_validate -0.174239660889248 0.000877182003816596 NA NA NA hsa-miR-93-5p JAK1 1.7515174434778 1.59386482413883e-08 -0.136842202385446 0.389827921807066 MirTarget;miRNATAP -0.119943568360841 0.000560781167464368 NA NA NA hsa-let-7a-3p JAK2 0.503048155002889 0.0411145454335299 -0.411963460232815 0.202983998863373 mirMAP;miRNATAP -0.317263862892994 0.000724186448180031 NA NA NA hsa-miR-337-3p JAK2 -0.722905798364932 0.0337389336330079 -0.411963460232815 0.202983998863373 PITA -0.251148982975929 0.00017817914602114 NA NA NA hsa-miR-3065-5p JAK3 -0.241623656423063 0.633116553078159 0.536999198640745 0.127187071032972 MirTarget;mirMAP -0.205432454309017 4.22150056081198e-05 NA NA NA hsa-let-7f-1-3p LEPR 1.28704406797397 1.17954701106157e-06 -2.83436342230666 4.63169005276204e-12 mirMAP -0.316325938369541 0.00579244075489481 NA NA NA hsa-miR-107 LEPR 0.904627575346218 4.67936495073904e-05 -2.83436342230666 4.63169005276204e-12 miRanda -0.617279796251265 6.21888987670775e-06 NA NA NA hsa-miR-130b-5p LEPR 0.701350393759937 0.0510142718395002 -2.83436342230666 4.63169005276204e-12 mirMAP -0.342581402776455 5.63656153406161e-05 NA NA NA hsa-miR-146b-5p LEPR 1.547491371264 6.06614361290688e-08 -2.83436342230666 4.63169005276204e-12 miRanda -0.276148443003039 0.00878010564976347 NA NA NA hsa-miR-16-1-3p LEPR 1.43227522002564 3.70920454953168e-08 -2.83436342230666 4.63169005276204e-12 mirMAP -0.615300989084393 4.5361235036154e-08 NA NA NA hsa-miR-16-2-3p LEPR 1.8048179609245 2.83095715136409e-09 -2.83436342230666 4.63169005276204e-12 mirMAP -0.578760249443591 8.8684385437177e-10 NA NA NA hsa-miR-23a-3p LEPR 1.10685926969665 3.16223452471768e-08 -2.83436342230666 4.63169005276204e-12 mirMAP -0.468365931987939 0.00204525409979654 NA NA NA hsa-miR-320a LEPR 0.593888711838028 0.011897419390526 -2.83436342230666 4.63169005276204e-12 miRanda -0.523607161893136 6.13770515680244e-05 NA NA NA hsa-miR-320b LEPR 1.11183660885284 0.000497971211648503 -2.83436342230666 4.63169005276204e-12 miRanda -0.425567859035637 6.62767766825677e-06 NA NA NA hsa-miR-335-3p LEPR 2.5197689063267 2.20084506976733e-09 -2.83436342230666 4.63169005276204e-12 mirMAP -0.519735344946296 2.30841484169211e-15 NA NA NA hsa-miR-335-5p LEPR 1.59953351087307 5.56170899867314e-05 -2.83436342230666 4.63169005276204e-12 miRNAWalker2_validate -0.347907116815692 3.72380099306025e-06 NA NA NA hsa-miR-33a-3p LEPR 0.347011402017138 0.321709379745392 -2.83436342230666 4.63169005276204e-12 mirMAP -0.284914364917746 0.00221075099848085 NA NA NA hsa-miR-3662 LEPR 1.82780708047676 0.0054036501346178 -2.83436342230666 4.63169005276204e-12 mirMAP -0.197956160699025 0.000985409859956534 NA NA NA hsa-miR-3682-3p LEPR 1.96838261925327 4.94885331227292e-06 -2.83436342230666 4.63169005276204e-12 mirMAP -0.331736170731052 5.66094847126262e-05 NA NA NA hsa-miR-421 LEPR 1.80720854070385 1.59709651202848e-07 -2.83436342230666 4.63169005276204e-12 miRanda -0.464573805556141 3.95967405939667e-08 NA NA NA hsa-miR-429 LEPR 1.40182602301928 0.00900426780286475 -2.83436342230666 4.63169005276204e-12 miRanda;miRNATAP -0.171905137130745 0.0025527432765032 NA NA NA hsa-miR-576-5p LEPR 0.625714137488957 0.0417100301848969 -2.83436342230666 4.63169005276204e-12 PITA -0.433465274705193 1.30511728139489e-05 NA NA NA hsa-miR-590-3p LEPR 1.11654983899947 0.000160782154924864 -2.83436342230666 4.63169005276204e-12 miRanda;mirMAP -0.393749686935348 0.000123996451952485 NA NA NA hsa-miR-590-5p LEPR 1.04171442093217 0.000272475544954865 -2.83436342230666 4.63169005276204e-12 miRanda -0.544008975471127 2.00739433097434e-07 NA NA NA hsa-miR-7-1-3p LEPR 0.709309110750947 0.0412301737463194 -2.83436342230666 4.63169005276204e-12 mirMAP -0.373413004482997 2.10149511585025e-05 NA NA NA hsa-miR-877-5p LEPR 2.17859965442336 1.03593450648516e-07 -2.83436342230666 4.63169005276204e-12 miRNAWalker2_validate -0.368123137885164 2.40247096034694e-07 NA NA NA hsa-miR-125b-5p LIF -0.509303501421334 0.133265526313161 1.71462884407601 0.000855811781095696 miRNAWalker2_validate;mirMAP -0.312767267698587 0.00429680556976322 NA NA NA hsa-miR-149-5p LIF 0.706277554734069 0.296848731347677 1.71462884407601 0.000855811781095696 mirMAP -0.314980705597704 2.20532264849102e-09 NA NA NA hsa-miR-224-5p LIF 2.7648036144402 0.000111736336240167 1.71462884407601 0.000855811781095696 mirMAP -0.219876605420943 1.08150172270977e-05 NA NA NA hsa-miR-2355-5p LIF 0.594869787574182 0.120591076715177 1.71462884407601 0.000855811781095696 mirMAP -0.273853979397091 0.00464303110390846 NA NA NA hsa-miR-708-5p LIF 1.41830449251856 0.0109647946476309 1.71462884407601 0.000855811781095696 miRNATAP -0.360109397028826 1.74849949937255e-08 NA NA NA hsa-let-7f-1-3p LIFR 1.28704406797397 1.17954701106157e-06 -3.61981086260957 1.25604132593787e-10 mirMAP -0.762869269877111 6.02137659192497e-07 NA NA NA hsa-miR-128-3p LIFR 0.98280381420517 5.77641850797209e-05 -3.61981086260957 1.25604132593787e-10 miRNAWalker2_validate -0.688358509827232 4.92551316644208e-05 NA NA NA hsa-miR-1296-5p LIFR 1.24127275671822 0.000834150627135999 -3.61981086260957 1.25604132593787e-10 miRNAWalker2_validate -0.355056034059912 0.00151693288388522 NA NA NA hsa-miR-182-5p LIFR 0.887369486030646 0.0310640781418789 -3.61981086260957 1.25604132593787e-10 mirMAP -0.347858788544219 0.000612171336107883 NA NA NA hsa-miR-19a-3p LIFR 1.26669687448473 0.000105972838514412 -3.61981086260957 1.25604132593787e-10 mirMAP -0.360893615098755 0.00458268075050526 NA NA NA hsa-miR-203a-3p LIFR 1.44736908507496 0.0394116388736904 -3.61981086260957 1.25604132593787e-10 MirTarget -0.343357678650422 2.27134187280079e-09 NA NA NA hsa-miR-21-5p LIFR 1.75445050487988 2.41825549682022e-23 -3.61981086260957 1.25604132593787e-10 miRNAWalker2_validate -0.614272808817945 0.00475386435307012 NA NA NA hsa-miR-221-3p LIFR 1.33496247538338 3.82022531235275e-07 -3.61981086260957 1.25604132593787e-10 miRNATAP -0.538429965079692 0.000566605536914086 NA NA NA hsa-miR-222-3p LIFR 1.39382731585819 9.98182478024671e-07 -3.61981086260957 1.25604132593787e-10 miRNATAP -0.423815700282025 0.00340879800617976 NA NA NA hsa-miR-224-3p LIFR 1.52422171450716 0.00650463542340912 -3.61981086260957 1.25604132593787e-10 mirMAP -0.27362012293532 0.000765590444828506 NA NA NA hsa-miR-23a-3p LIFR 1.10685926969665 3.16223452471768e-08 -3.61981086260957 1.25604132593787e-10 mirMAP -1.09577973648988 5.68378565524575e-08 NA NA NA hsa-miR-27a-3p LIFR 1.29886998470345 2.68986118553486e-08 -3.61981086260957 1.25604132593787e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.867706736542677 4.84489010013338e-07 NA NA NA hsa-miR-320b LIFR 1.11183660885284 0.000497971211648503 -3.61981086260957 1.25604132593787e-10 miRanda -0.399875752160973 0.00219840650098421 NA NA NA hsa-miR-335-3p LIFR 2.5197689063267 2.20084506976733e-09 -3.61981086260957 1.25604132593787e-10 MirTarget -0.441563764186986 2.7014711517078e-06 NA NA NA hsa-miR-3682-3p LIFR 1.96838261925327 4.94885331227292e-06 -3.61981086260957 1.25604132593787e-10 mirMAP -0.513558655736025 4.19609324249553e-06 NA NA NA hsa-miR-421 LIFR 1.80720854070385 1.59709651202848e-07 -3.61981086260957 1.25604132593787e-10 mirMAP -0.441412028522534 0.000176596776967541 NA NA NA hsa-miR-429 LIFR 1.40182602301928 0.00900426780286475 -3.61981086260957 1.25604132593787e-10 miRanda -0.273561623064286 0.000404358912522121 NA NA NA hsa-miR-590-5p LIFR 1.04171442093217 0.000272475544954865 -3.61981086260957 1.25604132593787e-10 PITA;miRNATAP -0.619438685811861 1.74801521038203e-05 NA NA NA hsa-miR-629-3p LIFR 1.40326397107309 9.7803063526732e-05 -3.61981086260957 1.25604132593787e-10 miRNATAP -0.360770597948738 0.00170252555524776 NA NA NA hsa-miR-940 LIFR 1.64406174271686 0.000690854900107004 -3.61981086260957 1.25604132593787e-10 MirTarget -0.404142170354556 5.71875622993419e-05 NA NA NA hsa-miR-96-5p LIFR 1.14243043653372 0.00942969392739105 -3.61981086260957 1.25604132593787e-10 mirMAP -0.402264424434053 4.55886904361715e-05 NA NA NA hsa-miR-98-5p LIFR 0.919961309193122 2.61963790596372e-05 -3.61981086260957 1.25604132593787e-10 miRNAWalker2_validate -0.655751389086584 0.000599793782919186 NA NA NA hsa-miR-151a-5p MPL 1.24363461949586 2.18236940049108e-07 -0.710004243031354 0.00708438685663001 miRNAWalker2_validate;miRTarBase -0.27435387543752 0.000342066207505944 NA NA NA hsa-miR-339-5p MPL 0.770566566962108 0.00816529093411862 -0.710004243031354 0.00708438685663001 miRanda -0.182666506876216 0.0047687994994266 NA NA NA hsa-miR-342-5p MPL 0.692955062695486 0.030998736359949 -0.710004243031354 0.00708438685663001 MirTarget -0.181626068585126 0.00193928346786654 NA NA NA hsa-miR-455-5p MPL 1.20462751989145 6.74386011867484e-05 -0.710004243031354 0.00708438685663001 MirTarget;miRanda -0.259172275454002 2.02186482109124e-05 NA NA NA hsa-miR-708-3p MPL 0.623782703831307 0.275355868302311 -0.710004243031354 0.00708438685663001 miRNAWalker2_validate;miRTarBase -0.122318726317029 0.000177035540539138 NA NA NA hsa-miR-708-5p MPL 1.41830449251856 0.0109647946476309 -0.710004243031354 0.00708438685663001 MirTarget -0.116274622030308 0.000483759137558732 NA NA NA hsa-let-7g-5p MYC 0.325297685027927 0.241142963826631 0.519157788027723 0.0906694636452631 miRNAWalker2_validate;miRTarBase -0.208004338135784 0.00889968380877331 NA NA NA hsa-miR-26a-5p MYC -0.384110714440647 0.0442498636014044 0.519157788027723 0.0906694636452631 miRNAWalker2_validate -0.595250601703361 1.86863162610225e-07 21901171 Our results identify new molecular targets of c-Myc in AML and highlight miR-26a attractiveness as a therapeutic target in leukemia acute myeloid leukemia hsa-miR-335-5p MYC 1.59953351087307 5.56170899867314e-05 0.519157788027723 0.0906694636452631 miRNAWalker2_validate -0.211331388667708 7.8766835557931e-05 NA NA NA hsa-miR-34a-5p MYC 0.794251341270032 0.00024017386701179 0.519157788027723 0.0906694636452631 miRNAWalker2_validate;miRTarBase -0.342899797750895 0.000672118391671011 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-423-5p MYC 0.832613878736338 0.000791321227103338 0.519157788027723 0.0906694636452631 miRNAWalker2_validate -0.242528994449528 0.00588609161419062 NA NA NA hsa-let-7d-5p OSMR 0.981733854788227 7.26366577706469e-07 0.590228118350084 0.0812933663771449 miRNATAP -0.339681364272053 0.00496611114718156 NA NA NA hsa-let-7g-5p OSMR 0.325297685027927 0.241142963826631 0.590228118350084 0.0812933663771449 miRNATAP -0.314063202702883 0.000311942259010435 NA NA NA hsa-miR-1254 OSMR 0.941374574140312 0.0605480748500796 0.590228118350084 0.0812933663771449 MirTarget -0.151695339983525 0.00876421469129444 NA NA NA hsa-miR-200b-3p OSMR 0.974577911407732 0.0595020056914543 0.590228118350084 0.0812933663771449 TargetScan -0.225656129510987 6.7751150942655e-07 NA NA NA hsa-miR-335-5p OSMR 1.59953351087307 5.56170899867314e-05 0.590228118350084 0.0812933663771449 miRNAWalker2_validate -0.282216408467629 1.4251612735117e-06 NA NA NA hsa-miR-429 OSMR 1.40182602301928 0.00900426780286475 0.590228118350084 0.0812933663771449 miRanda;miRNATAP -0.217215075958494 6.16481777674182e-07 NA NA NA hsa-miR-616-5p OSMR 0.834052908652744 0.0347835664029363 0.590228118350084 0.0812933663771449 MirTarget -0.164539260974257 0.00807935806779158 NA NA NA hsa-miR-98-5p OSMR 0.919961309193122 2.61963790596372e-05 0.590228118350084 0.0812933663771449 miRNAWalker2_validate -0.329012764090757 0.00271809883209831 NA NA NA hsa-miR-142-5p PIAS2 1.55592486377018 6.69269968016779e-06 -0.456763264637503 0.0413428093026653 mirMAP -0.187997056228137 2.45019097717657e-05 NA NA NA hsa-miR-10a-5p PIAS3 -0.470861534765518 0.148803248989189 0.153591562165115 0.496806117672322 miRNAWalker2_validate -0.217965335830787 6.85062616733503e-06 NA NA NA hsa-miR-18a-5p PIAS3 2.20211504140984 1.78678887916334e-09 0.153591562165115 0.496806117672322 MirTarget -0.126111520727568 0.00258086683505432 27198161 Further functional experiments indicate that CASC2 could directly upregulate PIAS3 expression by functioning as a competing endogenous RNA ceRNA for miR-18a colorectal cancer hsa-miR-532-3p PIAS3 0.552364451472481 0.0975490365586023 0.153591562165115 0.496806117672322 miRNATAP -0.227577105456164 1.39151836406506e-06 NA NA NA hsa-miR-126-5p PIK3CA 0.41765430251855 0.0753161203651532 0.181162005416898 0.379919524282219 mirMAP -0.230165325454576 0.000229328041159233 NA NA NA hsa-miR-146a-5p PIK3CA 1.82051649415508 2.03651725047679e-05 0.181162005416898 0.379919524282219 mirMAP -0.130514283326015 8.03472410512393e-05 NA NA NA hsa-miR-148a-5p PIK3CA -0.69329616490858 0.0793012233740369 0.181162005416898 0.379919524282219 mirMAP -0.160710142606256 9.74691916818117e-06 NA NA NA hsa-miR-148b-3p PIK3CA 0.295175884456199 0.17466422420702 0.181162005416898 0.379919524282219 miRNAWalker2_validate -0.270665697414514 6.25461929338548e-05 NA NA NA hsa-miR-186-5p PIK3CA 0.149964130725901 0.434709542998771 0.181162005416898 0.379919524282219 mirMAP -0.283664174467296 0.000254482000083255 NA NA NA hsa-miR-29b-1-5p PIK3CA 0.606560155953522 0.116355599574769 0.181162005416898 0.379919524282219 mirMAP -0.105962073023743 0.00514891759991948 NA NA NA hsa-miR-320b PIK3CA 1.11183660885284 0.000497971211648503 0.181162005416898 0.379919524282219 miRanda -0.131928082159166 0.00355606170878243 NA NA NA hsa-miR-335-5p PIK3CA 1.59953351087307 5.56170899867314e-05 0.181162005416898 0.379919524282219 miRNAWalker2_validate -0.142668444274705 6.55217134166698e-05 NA NA NA hsa-miR-338-5p PIK3CA -1.19659203838734 0.0100316010080496 0.181162005416898 0.379919524282219 mirMAP -0.128160056012068 3.12181075963217e-05 NA NA NA hsa-miR-501-5p PIK3CA 0.266919328110625 0.454779001968586 0.181162005416898 0.379919524282219 mirMAP -0.184484665922465 4.78508048904086e-06 NA NA NA hsa-miR-7-1-3p PIK3CA 0.709309110750947 0.0412301737463194 0.181162005416898 0.379919524282219 mirMAP -0.18347710340594 9.07765701687707e-06 NA NA NA hsa-miR-130a-3p PIK3CB 0.146223920674657 0.633739795905839 0.248944033508746 0.180378115579181 miRNATAP -0.141347568269357 0.0010035949231668 NA NA NA hsa-miR-1468-5p PIK3CD -1.88350218312373 3.31332405201189e-05 0.391814669139483 0.253077445924908 MirTarget -0.217696918010317 3.06934786857079e-05 NA NA NA hsa-miR-30b-3p PIK3CD -0.266398938200332 0.400847813143994 0.391814669139483 0.253077445924908 MirTarget -0.431008741394064 8.57729594514163e-09 NA NA NA hsa-miR-30b-5p PIK3CD -0.430720743745757 0.0593564057320791 0.391814669139483 0.253077445924908 MirTarget -0.481822586915696 5.93876910377637e-06 NA NA NA hsa-miR-30d-5p PIK3CD -0.5492586056147 0.0140125082460125 0.391814669139483 0.253077445924908 MirTarget;miRNATAP -0.669349357920634 2.53796175626459e-10 NA NA NA hsa-miR-616-5p PIK3CD 0.834052908652744 0.0347835664029363 0.391814669139483 0.253077445924908 MirTarget -0.171408745877689 0.0062816347712319 NA NA NA hsa-miR-7-5p PIK3CD 1.63575693499363 0.0124424214624534 0.391814669139483 0.253077445924908 miRTarBase;MirTarget;miRNATAP -0.205801781586893 4.40558507915807e-08 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway liver cancer hsa-miR-103a-3p PIK3R1 0.840525139266028 5.83536475789158e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.323457232113071 0.0039447769693221 NA NA NA hsa-miR-106b-5p PIK3R1 1.70863907461894 2.04074794107142e-08 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.253346436583178 1.72729352701852e-05 NA NA NA hsa-miR-107 PIK3R1 0.904627575346218 4.67936495073904e-05 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda;miRNATAP -0.238654922729134 0.0046938788179217 NA NA NA hsa-miR-128-3p PIK3R1 0.98280381420517 5.77641850797209e-05 -1.09428616452248 2.46783518047221e-05 MirTarget -0.253825409257793 0.000861541031670611 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-144-3p PIK3R1 -0.13309578176575 0.798245647923351 -1.09428616452248 2.46783518047221e-05 mirMAP -0.138673461850839 0.000126186382128809 NA NA NA hsa-miR-15b-5p PIK3R1 1.62046407540723 5.42152621571078e-09 -1.09428616452248 2.46783518047221e-05 MirTarget -0.323211150072369 4.46298725379362e-07 NA NA NA hsa-miR-16-2-3p PIK3R1 1.8048179609245 2.83095715136409e-09 -1.09428616452248 2.46783518047221e-05 MirTarget -0.270383492169966 3.99207467881518e-06 NA NA NA hsa-miR-16-5p PIK3R1 1.00515772948091 5.33912942007619e-06 -1.09428616452248 2.46783518047221e-05 MirTarget -0.405416526556489 9.69480909855754e-07 NA NA NA hsa-miR-17-5p PIK3R1 1.65862087862483 8.45603406215941e-08 -1.09428616452248 2.46783518047221e-05 MirTarget;TargetScan;miRNATAP -0.192199170444737 0.00107429271534319 NA NA NA hsa-miR-182-5p PIK3R1 0.887369486030646 0.0310640781418789 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.160218491940506 0.000398426335382569 NA NA NA hsa-miR-185-5p PIK3R1 1.14351510556643 1.07346945085714e-08 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.41775889137189 4.21636400438791e-06 NA NA NA hsa-miR-188-5p PIK3R1 1.35426907033843 0.00038346077691455 -1.09428616452248 2.46783518047221e-05 MirTarget -0.162900447887926 0.000775923703794411 NA NA NA hsa-miR-200b-3p PIK3R1 0.974577911407732 0.0595020056914543 -1.09428616452248 2.46783518047221e-05 mirMAP -0.103803538669649 0.00409847558383849 NA NA NA hsa-miR-200c-3p PIK3R1 1.28185685499076 0.00369777635539177 -1.09428616452248 2.46783518047221e-05 mirMAP -0.143316221972735 0.00063899158230993 NA NA NA hsa-miR-20a-5p PIK3R1 1.4503375861709 5.7813456424762e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.175478538743826 0.0056099063555159 NA NA NA hsa-miR-21-5p PIK3R1 1.75445050487988 2.41825549682022e-23 -1.09428616452248 2.46783518047221e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.306402457018565 0.00154965993784699 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.960352937108106 0.00133449812322732 -1.09428616452248 2.46783518047221e-05 MirTarget -0.22956448368642 0.000224776230276284 NA NA NA hsa-miR-22-5p PIK3R1 0.804348748654247 0.000804065112767412 -1.09428616452248 2.46783518047221e-05 mirMAP -0.271562984507077 0.000499671844853285 NA NA NA hsa-miR-221-3p PIK3R1 1.33496247538338 3.82022531235275e-07 -1.09428616452248 2.46783518047221e-05 MirTarget -0.313499877783358 5.35467630228685e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.39382731585819 9.98182478024671e-07 -1.09428616452248 2.46783518047221e-05 MirTarget -0.284754511073413 7.61572703183408e-06 NA NA NA hsa-miR-3065-5p PIK3R1 -0.241623656423063 0.633116553078159 -1.09428616452248 2.46783518047221e-05 MirTarget;mirMAP;miRNATAP -0.124182539774803 0.00105993614946939 NA NA NA hsa-miR-32-3p PIK3R1 0.583525764322974 0.11837203008551 -1.09428616452248 2.46783518047221e-05 mirMAP -0.17265888879632 0.00228085828010069 NA NA NA hsa-miR-320b PIK3R1 1.11183660885284 0.000497971211648503 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.162259703959997 0.00544641812773208 NA NA NA hsa-miR-324-3p PIK3R1 1.04940352369965 0.000387716796520961 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.184232658949902 0.00347746569584922 NA NA NA hsa-miR-330-3p PIK3R1 0.798460296022179 0.00746538156533435 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.26440540068663 2.08637052595379e-05 NA NA NA hsa-miR-335-3p PIK3R1 2.5197689063267 2.20084506976733e-09 -1.09428616452248 2.46783518047221e-05 mirMAP -0.148076206465714 0.000495756694433814 NA NA NA hsa-miR-424-5p PIK3R1 1.08509868581983 0.000420473853818268 -1.09428616452248 2.46783518047221e-05 MirTarget -0.287369315123124 1.32105570633977e-06 NA NA NA hsa-miR-429 PIK3R1 1.40182602301928 0.00900426780286475 -1.09428616452248 2.46783518047221e-05 mirMAP;miRNATAP -0.126994249956039 0.00022771493817442 NA NA NA hsa-miR-455-3p PIK3R1 2.29532323519288 1.85675588946527e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.181586331748295 8.05157474846207e-06 NA NA NA hsa-miR-542-3p PIK3R1 0.757649022262991 0.00210575463285599 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda -0.239065351988831 0.0017318237826115 NA NA NA hsa-miR-584-5p PIK3R1 1.68234626630933 0.000166828539264215 -1.09428616452248 2.46783518047221e-05 mirMAP -0.129450210806705 0.00170622715972499 NA NA NA hsa-miR-590-3p PIK3R1 1.11654983899947 0.000160782154924864 -1.09428616452248 2.46783518047221e-05 miRanda;mirMAP -0.266046553887174 1.8351581859886e-05 NA NA NA hsa-miR-590-5p PIK3R1 1.04171442093217 0.000272475544954865 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda;miRNATAP -0.297910761408884 3.33366270664506e-06 NA NA NA hsa-miR-629-3p PIK3R1 1.40326397107309 9.7803063526732e-05 -1.09428616452248 2.46783518047221e-05 MirTarget -0.16619442916244 0.00118253063445621 NA NA NA hsa-miR-96-5p PIK3R1 1.14243043653372 0.00942969392739105 -1.09428616452248 2.46783518047221e-05 TargetScan;miRNATAP -0.193630203103858 1.00718533638407e-05 NA NA NA hsa-miR-30a-5p PIK3R2 -1.71922855140016 3.20574349285256e-07 0.00922907299312037 0.961081205853821 miRNATAP -0.137164224996737 0.000346855164996688 NA NA NA hsa-miR-1271-5p PIK3R3 1.15538250415776 0.00207865862606828 -0.662491536689023 0.0210304127874503 mirMAP -0.197799197361284 0.00028487328401707 NA NA NA hsa-miR-185-3p PIK3R3 1.33711019171256 3.45756583967985e-05 -0.662491536689023 0.0210304127874503 MirTarget -0.200301326896551 0.00130353125166929 NA NA NA hsa-miR-511-5p PIK3R3 0.542335183701817 0.127507740178883 -0.662491536689023 0.0210304127874503 MirTarget -0.231823970894027 4.82261601939889e-05 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-708-3p PIK3R3 0.623782703831307 0.275355868302311 -0.662491536689023 0.0210304127874503 mirMAP -0.147502347303041 2.93933869168246e-05 NA NA NA hsa-miR-182-5p PIK3R5 0.887369486030646 0.0310640781418789 -0.106061319644644 0.802628610118832 MirTarget -0.363007599134275 3.56264538888151e-07 NA NA NA hsa-miR-18a-3p PIK3R5 2.35188582849667 1.39401350286321e-08 -0.106061319644644 0.802628610118832 MirTarget -0.215221108190999 0.00210782353217643 NA NA NA hsa-let-7g-3p PIM1 0.64979533805273 0.0103084600883006 -0.297437313650164 0.3899427559526 miRNATAP -0.357118489847683 0.000225527302706615 NA NA NA hsa-miR-15a-5p PIM1 1.03783090449383 7.40334108980898e-07 -0.297437313650164 0.3899427559526 miRNATAP -0.459032602515081 6.46328327394202e-05 NA NA NA hsa-miR-16-5p PIM1 1.00515772948091 5.33912942007619e-06 -0.297437313650164 0.3899427559526 miRNAWalker2_validate;miRTarBase;miRNATAP -0.311181051383544 0.00483965735089867 NA NA NA hsa-miR-186-5p PIM1 0.149964130725901 0.434709542998771 -0.297437313650164 0.3899427559526 mirMAP -0.532707629775997 4.20834129144998e-05 NA NA NA hsa-miR-192-5p PIM1 0.0809146624034405 0.941057093528709 -0.297437313650164 0.3899427559526 miRNAWalker2_validate -0.139564691890616 7.10389203580354e-11 NA NA NA hsa-miR-335-5p PIM1 1.59953351087307 5.56170899867314e-05 -0.297437313650164 0.3899427559526 miRNAWalker2_validate -0.246048407009935 4.28704123202743e-05 NA NA NA hsa-miR-339-5p PIM1 0.770566566962108 0.00816529093411862 -0.297437313650164 0.3899427559526 miRanda -0.307930818719238 0.000236983259739807 NA NA NA hsa-miR-429 PIM1 1.40182602301928 0.00900426780286475 -0.297437313650164 0.3899427559526 miRNATAP -0.181837441153581 5.06458996839275e-05 NA NA NA hsa-miR-532-3p PIM1 0.552364451472481 0.0975490365586023 -0.297437313650164 0.3899427559526 miRNATAP -0.389770185747879 5.89646114200651e-08 NA NA NA hsa-miR-577 PIM1 0.911619788986754 0.2256062124148 -0.297437313650164 0.3899427559526 PITA -0.195574314827226 1.13481903047944e-09 NA NA NA hsa-miR-616-5p PIM1 0.834052908652744 0.0347835664029363 -0.297437313650164 0.3899427559526 mirMAP -0.238666754790545 0.00014053076906577 NA NA NA hsa-miR-7-5p PIM1 1.63575693499363 0.0124424214624534 -0.297437313650164 0.3899427559526 miRNATAP -0.176057542058317 4.40834287810026e-06 NA NA NA hsa-let-7i-5p PRLR 0.798954594465461 2.99735653959449e-05 -1.89609622376219 0.0101234287959838 miRNATAP -0.855407120682147 0.0020143856121384 NA NA NA hsa-miR-218-5p PRLR -0.987730614742492 0.0108295837207062 -1.89609622376219 0.0101234287959838 miRNATAP -0.406480604406767 0.0027019181607033 NA NA NA hsa-miR-34c-5p PRLR 2.20632574870337 0.000379662996168678 -1.89609622376219 0.0101234287959838 miRanda;miRNATAP -0.448293175794544 4.58046531826808e-08 NA NA NA hsa-miR-944 PRLR 3.33123095809751 0.0177835044930391 -1.89609622376219 0.0101234287959838 mirMAP -0.247865381017898 7.64517683238236e-09 NA NA NA hsa-let-7b-3p PTPN11 0.21838629112113 0.296038413622566 -0.154790111247342 0.236179705145447 mirMAP -0.14630631158987 0.00102525420613718 NA NA NA hsa-miR-16-1-3p SOCS2 1.43227522002564 3.70920454953168e-08 -1.68580694260179 2.21502650636839e-06 mirMAP -0.333086360670726 0.000586858914128211 NA NA NA hsa-miR-16-5p SOCS2 1.00515772948091 5.33912942007619e-06 -1.68580694260179 2.21502650636839e-06 miRNAWalker2_validate -0.51605698062172 7.35444514673599e-06 NA NA NA hsa-miR-19a-3p SOCS2 1.26669687448473 0.000105972838514412 -1.68580694260179 2.21502650636839e-06 mirMAP -0.258158310147057 0.000975955255446159 NA NA NA hsa-miR-19b-3p SOCS2 0.759818275708988 0.00652779573186786 -1.68580694260179 2.21502650636839e-06 mirMAP -0.280326134709248 0.00259706709988879 NA NA NA hsa-miR-20a-3p SOCS2 1.13957127410163 0.000451087640268489 -1.68580694260179 2.21502650636839e-06 miRNATAP -0.335536524498864 1.81936950193484e-05 NA NA NA hsa-miR-25-3p SOCS2 1.00604871526544 0.000421838061147906 -1.68580694260179 2.21502650636839e-06 mirMAP -0.247894944407904 0.00625330818930109 NA NA NA hsa-miR-320a SOCS2 0.593888711838028 0.011897419390526 -1.68580694260179 2.21502650636839e-06 miRanda -0.346219378356997 0.00178759194896607 NA NA NA hsa-miR-320b SOCS2 1.11183660885284 0.000497971211648503 -1.68580694260179 2.21502650636839e-06 miRanda -0.274830923312858 0.000627274289645561 NA NA NA hsa-miR-320c SOCS2 0.455072851945474 0.240613785444485 -1.68580694260179 2.21502650636839e-06 miRanda -0.264288016700346 0.000648330551538215 NA NA NA hsa-miR-324-5p SOCS2 1.08820215809537 3.11674414561836e-05 -1.68580694260179 2.21502650636839e-06 miRanda -0.379876760954754 0.00010073045037813 NA NA NA hsa-miR-429 SOCS2 1.40182602301928 0.00900426780286475 -1.68580694260179 2.21502650636839e-06 miRNATAP -0.132523491499005 0.0058059584898242 NA NA NA hsa-miR-576-5p SOCS2 0.625714137488957 0.0417100301848969 -1.68580694260179 2.21502650636839e-06 PITA -0.322365723256771 0.00012751788338021 NA NA NA hsa-miR-590-3p SOCS2 1.11654983899947 0.000160782154924864 -1.68580694260179 2.21502650636839e-06 mirMAP -0.274964650468 0.00154681980300477 NA NA NA hsa-miR-940 SOCS2 1.64406174271686 0.000690854900107004 -1.68580694260179 2.21502650636839e-06 miRNATAP -0.241796614257409 9.80750551972828e-05 NA NA NA hsa-miR-130b-5p SOCS3 0.701350393759937 0.0510142718395002 -0.105697939447357 0.761099584319298 mirMAP -0.311249055618694 3.93978055200972e-06 NA NA NA hsa-miR-30c-5p SOCS3 -0.983130268805942 4.60419218706127e-05 -0.105697939447357 0.761099584319298 miRNAWalker2_validate -0.306953975534321 0.00249424177729945 26707189 Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR 30c in breast cancer; Our results further showed that the level of SOCS3 expression was induced by isolinderalactone due to inhibiting the microRNA hsa-miR-30c-5p miR-30c expression; In conclusion isolinderalactone induces apoptosis in MDA-MB‑231 cells and suppresses STAT3 signaling pathway through regulation of SOCS3 and miR-30c breast cancer hsa-miR-339-5p SOCS3 0.770566566962108 0.00816529093411862 -0.105697939447357 0.761099584319298 miRanda -0.353368675011369 2.39154564706523e-05 NA NA NA hsa-miR-629-3p SOCS3 1.40326397107309 9.7803063526732e-05 -0.105697939447357 0.761099584319298 mirMAP -0.233718218976423 0.000497059806101637 NA NA NA hsa-miR-629-5p SOCS3 1.06377074768516 0.000536624707722274 -0.105697939447357 0.761099584319298 mirMAP -0.260050849232248 0.00108943968885832 NA NA NA hsa-let-7a-3p SOCS4 0.503048155002889 0.0411145454335299 -0.101237667355627 0.530432366433126 mirMAP -0.145910979067942 0.00166966791726035 NA NA NA hsa-let-7b-3p SOCS4 0.21838629112113 0.296038413622566 -0.101237667355627 0.530432366433126 mirMAP -0.187310148067364 0.000697721874524131 NA NA NA hsa-let-7b-5p SOCS4 0.0582902155815681 0.781400138984745 -0.101237667355627 0.530432366433126 miRNATAP -0.176622141996121 0.00135113150496157 NA NA NA hsa-let-7f-1-3p SOCS4 1.28704406797397 1.17954701106157e-06 -0.101237667355627 0.530432366433126 mirMAP -0.111318153652571 0.00824523553940991 NA NA NA hsa-miR-107 SOCS4 0.904627575346218 4.67936495073904e-05 -0.101237667355627 0.530432366433126 miRanda -0.186002496426781 0.000237900815757438 NA NA NA hsa-miR-140-3p SOCS4 -0.296251775392129 0.127539826012144 -0.101237667355627 0.530432366433126 PITA;miRNATAP -0.190578953533771 0.0013993584773413 NA NA NA hsa-miR-142-5p SOCS4 1.55592486377018 6.69269968016779e-06 -0.101237667355627 0.530432366433126 mirMAP -0.141949754026346 7.47073054940738e-06 NA NA NA hsa-miR-27a-3p SOCS4 1.29886998470345 2.68986118553486e-08 -0.101237667355627 0.530432366433126 miRNATAP -0.139346173013636 0.0033193698708561 NA NA NA hsa-miR-27b-3p SOCS4 0.0836323965901755 0.725273923274 -0.101237667355627 0.530432366433126 miRNATAP -0.169981979362259 0.000421788781142969 NA NA NA hsa-let-7b-3p SOCS5 0.21838629112113 0.296038413622566 -0.107065600204288 0.423664397583578 mirMAP -0.128757105538818 0.00492796788758685 NA NA NA hsa-let-7f-1-3p SOCS5 1.28704406797397 1.17954701106157e-06 -0.107065600204288 0.423664397583578 mirMAP -0.153450058508181 7.1507268080861e-06 NA NA NA hsa-miR-107 SOCS5 0.904627575346218 4.67936495073904e-05 -0.107065600204288 0.423664397583578 miRanda -0.11575135805239 0.00594651378138345 NA NA NA hsa-miR-126-5p SOCS5 0.41765430251855 0.0753161203651532 -0.107065600204288 0.423664397583578 mirMAP -0.105751659156663 0.00895886758589893 NA NA NA hsa-miR-16-5p SOCS5 1.00515772948091 5.33912942007619e-06 -0.107065600204288 0.423664397583578 miRNAWalker2_validate -0.129609898896071 0.00203630815724404 NA NA NA hsa-miR-7-1-3p SOCS5 0.709309110750947 0.0412301737463194 -0.107065600204288 0.423664397583578 mirMAP -0.107864478903355 5.20431053310361e-05 NA NA NA hsa-miR-107 SOS1 0.904627575346218 4.67936495073904e-05 -0.312504597403338 0.0217354056927372 miRNATAP -0.145548441179847 0.000689923594720433 NA NA NA hsa-miR-212-3p SOS1 0.960352937108106 0.00133449812322732 -0.312504597403338 0.0217354056927372 miRNATAP -0.10285303580697 0.00125914157136999 NA NA NA hsa-miR-130b-3p SOS2 1.32714007211004 4.78676252285191e-05 -0.552553272187832 0.000842904756234712 miRNATAP -0.189945286925012 4.30620481406807e-08 NA NA NA hsa-miR-140-5p SOS2 0.208193069681326 0.303002433893804 -0.552553272187832 0.000842904756234712 miRanda -0.242708772607705 4.09198894582034e-05 NA NA NA hsa-miR-15a-5p SOS2 1.03783090449383 7.40334108980898e-07 -0.552553272187832 0.000842904756234712 miRNATAP -0.146415389758913 0.00881073243847914 NA NA NA hsa-miR-15b-5p SOS2 1.62046407540723 5.42152621571078e-09 -0.552553272187832 0.000842904756234712 miRNATAP -0.20706350866124 2.57218450390641e-07 NA NA NA hsa-miR-16-5p SOS2 1.00515772948091 5.33912942007619e-06 -0.552553272187832 0.000842904756234712 miRNATAP -0.262605428938621 4.24308774338413e-07 NA NA NA hsa-miR-320a SOS2 0.593888711838028 0.011897419390526 -0.552553272187832 0.000842904756234712 miRanda;miRNATAP -0.171180096354768 0.000654323522825758 NA NA NA hsa-miR-320b SOS2 1.11183660885284 0.000497971211648503 -0.552553272187832 0.000842904756234712 miRanda;miRNATAP -0.1894426744384 1.1640268989058e-07 NA NA NA hsa-miR-320c SOS2 0.455072851945474 0.240613785444485 -0.552553272187832 0.000842904756234712 miRanda;miRNATAP -0.140084445378509 6.27193555893877e-05 NA NA NA hsa-miR-330-3p SOS2 0.798460296022179 0.00746538156533435 -0.552553272187832 0.000842904756234712 PITA;miRNATAP -0.138104773165596 0.000447681879316435 NA NA NA hsa-miR-335-5p SOS2 1.59953351087307 5.56170899867314e-05 -0.552553272187832 0.000842904756234712 miRNAWalker2_validate -0.169702199646938 1.79676990124387e-09 NA NA NA hsa-miR-421 SOS2 1.80720854070385 1.59709651202848e-07 -0.552553272187832 0.000842904756234712 miRanda -0.144587437231913 1.02531118763523e-05 NA NA NA hsa-miR-424-5p SOS2 1.08509868581983 0.000420473853818268 -0.552553272187832 0.000842904756234712 miRNATAP -0.140604926460313 0.000199731330671148 NA NA NA hsa-miR-543 SOS2 0.0323775903217254 0.929458442755522 -0.552553272187832 0.000842904756234712 miRanda -0.111995751787288 0.00169071143522402 NA NA NA hsa-miR-590-3p SOS2 1.11654983899947 0.000160782154924864 -0.552553272187832 0.000842904756234712 miRanda;mirMAP -0.153192018213884 9.25459377799179e-05 NA NA NA hsa-miR-590-5p SOS2 1.04171442093217 0.000272475544954865 -0.552553272187832 0.000842904756234712 PITA;miRanda;miRNATAP -0.180915954835414 7.34917806636463e-06 NA NA NA hsa-miR-218-5p SPRED2 -0.987730614742492 0.0108295837207062 0.125162518170871 0.493554021708359 miRNATAP -0.117444803746874 0.000356086770211559 NA NA NA hsa-let-7a-3p SPRY1 0.503048155002889 0.0411145454335299 -0.733221705988037 0.0177545261837902 miRNATAP -0.528212032805113 1.44726392702999e-09 NA NA NA hsa-let-7b-3p SPRY1 0.21838629112113 0.296038413622566 -0.733221705988037 0.0177545261837902 miRNATAP -0.569480265615107 5.98153949988254e-08 NA NA NA hsa-miR-16-2-3p SPRY1 1.8048179609245 2.83095715136409e-09 -0.733221705988037 0.0177545261837902 mirMAP -0.374310314494938 3.9110281239593e-08 NA NA NA hsa-miR-20a-3p SPRY1 1.13957127410163 0.000451087640268489 -0.733221705988037 0.0177545261837902 miRNATAP -0.264464183055605 7.36167521287424e-05 NA NA NA hsa-miR-324-3p SPRY1 1.04940352369965 0.000387716796520961 -0.733221705988037 0.0177545261837902 miRNAWalker2_validate -0.40577336538679 1.68189473529151e-08 NA NA NA hsa-miR-34c-5p SPRY1 2.20632574870337 0.000379662996168678 -0.733221705988037 0.0177545261837902 miRanda -0.199196073542772 5.074521505572e-09 NA NA NA hsa-miR-3615 SPRY1 1.25850728223629 0.000102643804657077 -0.733221705988037 0.0177545261837902 miRNAWalker2_validate -0.244565475385242 0.000253640907661745 NA NA NA hsa-miR-455-3p SPRY1 2.29532323519288 1.85675588946527e-07 -0.733221705988037 0.0177545261837902 miRNATAP -0.351498181016525 1.08046824627885e-14 NA NA NA hsa-miR-590-5p SPRY1 1.04171442093217 0.000272475544954865 -0.733221705988037 0.0177545261837902 PITA;miRanda;miRNATAP -0.300940223664096 7.29336957570426e-05 NA NA NA hsa-let-7a-3p SPRY2 0.503048155002889 0.0411145454335299 -0.393980035220546 0.244059064340712 miRNATAP -0.316704885602825 0.00126188573759474 NA NA NA hsa-miR-23a-3p SPRY2 1.10685926969665 3.16223452471768e-08 -0.393980035220546 0.244059064340712 miRNATAP -0.635689398850943 3.22530121983477e-08 NA NA NA hsa-miR-23b-3p SPRY2 -0.286465516491361 0.18664668472995 -0.393980035220546 0.244059064340712 miRNATAP -0.300659414605396 0.00780437102137096 NA NA NA hsa-miR-27a-3p SPRY2 1.29886998470345 2.68986118553486e-08 -0.393980035220546 0.244059064340712 miRNAWalker2_validate;miRTarBase;miRNATAP -0.561903924700838 7.86611033825726e-09 20638779 By using a reporter-screening assay we discovered that the 3'UTR of Sprouty2 Spry2 carried a putative miR-27a binding site; Furthermore the Spry2 protein which has a low expression level in pancreatic adenocarcinoma was upregulated by transfection with a miR-27a inhibitor; The data reported here are the first to indicate that miR-27a plays an oncogenic role by targeting Spry2 and modulating the malignant biological behavior of pancreatic cancer cells malignant trasformation pancreatic cancer hsa-miR-27b-3p SPRY2 0.0836323965901755 0.725273923274 -0.393980035220546 0.244059064340712 miRNATAP -0.38831730953932 0.000136368175020847 NA NA NA hsa-miR-452-5p SPRY2 2.08756506185889 0.000258095769002813 -0.393980035220546 0.244059064340712 miRNATAP -0.296638673750862 1.98662400944037e-14 NA NA NA hsa-miR-455-5p SPRY2 1.20462751989145 6.74386011867484e-05 -0.393980035220546 0.244059064340712 miRanda -0.232064364386646 0.00310600935419565 NA NA NA hsa-let-7a-3p SPRY3 0.503048155002889 0.0411145454335299 -0.342883393260894 0.262142180786754 MirTarget;mirMAP -0.269639087362655 0.0024135430140927 NA NA NA hsa-let-7b-3p SPRY3 0.21838629112113 0.296038413622566 -0.342883393260894 0.262142180786754 MirTarget;mirMAP -0.279112054301239 0.0086556240429372 NA NA NA hsa-miR-1271-5p SPRY3 1.15538250415776 0.00207865862606828 -0.342883393260894 0.262142180786754 MirTarget -0.214638257895754 0.000200645739425443 NA NA NA hsa-miR-130b-3p SPRY3 1.32714007211004 4.78676252285191e-05 -0.342883393260894 0.262142180786754 mirMAP -0.239345276345185 0.000235670586848357 NA NA NA hsa-miR-15b-3p SPRY3 1.75738933306437 3.00554466232543e-08 -0.342883393260894 0.262142180786754 mirMAP -0.212474423704024 0.00130830020304753 NA NA NA hsa-miR-182-5p SPRY3 0.887369486030646 0.0310640781418789 -0.342883393260894 0.262142180786754 mirMAP -0.162760799091875 0.00192024182783168 NA NA NA hsa-miR-183-5p SPRY3 1.65900927871187 0.000522025364980187 -0.342883393260894 0.262142180786754 MirTarget -0.165198368718066 0.000199086244137912 NA NA NA hsa-miR-296-5p SPRY3 0.932146077883618 0.0602370559607489 -0.342883393260894 0.262142180786754 miRNATAP -0.118175159333823 0.00944123423994545 NA NA NA hsa-miR-320b SPRY3 1.11183660885284 0.000497971211648503 -0.342883393260894 0.262142180786754 miRanda;mirMAP -0.179687467371507 0.00776460710071227 NA NA NA hsa-miR-382-5p SPRY3 0.592305208032135 0.0451384362870204 -0.342883393260894 0.262142180786754 mirMAP -0.209606876356046 0.00446172138339029 NA NA NA hsa-miR-452-5p SPRY3 2.08756506185889 0.000258095769002813 -0.342883393260894 0.262142180786754 MirTarget;mirMAP -0.104624629590824 0.00507972543395335 NA NA NA hsa-miR-455-3p SPRY3 2.29532323519288 1.85675588946527e-07 -0.342883393260894 0.262142180786754 miRNATAP -0.207030671505507 1.07059832280426e-05 NA NA NA hsa-miR-590-3p SPRY3 1.11654983899947 0.000160782154924864 -0.342883393260894 0.262142180786754 mirMAP -0.208643192662664 0.00409490789575057 NA NA NA hsa-miR-629-5p SPRY3 1.06377074768516 0.000536624707722274 -0.342883393260894 0.262142180786754 MirTarget;mirMAP -0.238475131754043 0.00065693138937951 NA NA NA hsa-miR-708-5p SPRY3 1.41830449251856 0.0109647946476309 -0.342883393260894 0.262142180786754 MirTarget -0.123880699502271 0.00128369033286925 NA NA NA hsa-miR-96-5p SPRY3 1.14243043653372 0.00942969392739105 -0.342883393260894 0.262142180786754 MirTarget;TargetScan -0.156831967337718 0.00224449462301979 NA NA NA hsa-miR-34c-3p SPRY4 2.25273698056457 9.06191072601281e-05 0.525957515025839 0.103138661253723 PITA -0.188440144007747 1.2200165693355e-06 NA NA NA hsa-miR-452-3p SPRY4 2.2028815467959 0.00185370432491004 0.525957515025839 0.103138661253723 mirMAP -0.187947670809884 9.35436804928949e-08 NA NA NA hsa-miR-944 SPRY4 3.33123095809751 0.0177835044930391 0.525957515025839 0.103138661253723 PITA;mirMAP;miRNATAP -0.129073504330554 1.56292815483943e-12 NA NA NA hsa-miR-107 STAM2 0.904627575346218 4.67936495073904e-05 -0.485557384104961 0.000660525831592582 miRanda -0.1487681024034 0.00104851083657469 NA NA NA hsa-miR-142-5p STAM2 1.55592486377018 6.69269968016779e-06 -0.485557384104961 0.000660525831592582 mirMAP -0.102759240290076 0.000323586172995234 NA NA NA hsa-miR-15b-3p STAM2 1.75738933306437 3.00554466232543e-08 -0.485557384104961 0.000660525831592582 mirMAP -0.119600926351371 9.74406765055814e-05 NA NA NA hsa-miR-23a-3p STAM2 1.10685926969665 3.16223452471768e-08 -0.485557384104961 0.000660525831592582 mirMAP -0.236605280922859 1.35959881683957e-06 NA NA NA hsa-miR-23b-3p STAM2 -0.286465516491361 0.18664668472995 -0.485557384104961 0.000660525831592582 mirMAP -0.146962875886965 0.00199622450823541 NA NA NA hsa-miR-361-5p STAM2 0.407725414130987 0.0181260969156347 -0.485557384104961 0.000660525831592582 miRanda -0.245611360870127 4.03412420370125e-05 NA NA NA hsa-miR-379-5p STAM2 0.0928358360950554 0.768753888894121 -0.485557384104961 0.000660525831592582 MirTarget -0.113769298960299 0.000405654990627511 NA NA NA hsa-miR-421 STAM2 1.80720854070385 1.59709651202848e-07 -0.485557384104961 0.000660525831592582 MirTarget;miRanda;miRNATAP -0.107578075320387 0.000145764563941214 NA NA NA hsa-miR-744-5p STAM2 1.0861545801627 0.000122087743268849 -0.485557384104961 0.000660525831592582 miRNAWalker2_validate -0.166732431139974 1.77183469640677e-06 NA NA NA hsa-miR-92b-3p STAM2 1.33518446513417 1.45350885391576e-06 -0.485557384104961 0.000660525831592582 mirMAP -0.117621939285821 0.00101153009078947 NA NA NA hsa-miR-129-5p STAT1 -2.56914016541176 2.36237896095709e-06 1.52666952557908 4.18221513547034e-08 miRanda -0.151330421162999 4.00189607466532e-05 NA NA NA hsa-miR-30c-2-3p STAT1 -1.13954984520886 0.000846438233267901 1.52666952557908 4.18221513547034e-08 MirTarget -0.189921465872582 0.00137112517055884 NA NA NA hsa-let-7g-5p STAT2 0.325297685027927 0.241142963826631 0.667501075235704 0.000445245318873171 MirTarget -0.142024466734626 0.00413158732585832 NA NA NA hsa-miR-590-5p STAT3 1.04171442093217 0.000272475544954865 0.21444773174488 0.18542988779442 miRanda;miRNATAP -0.125047927211134 0.00154126856263987 27757042 We found that the AKT/ERK and STAT3 signaling pathways were activated by miR-590-5p overexpression gastric cancer hsa-miR-141-3p STAT4 1.45548825076434 0.00115958850961764 0.402913849290048 0.351234544078014 MirTarget;TargetScan -0.237750838857711 0.000416515719165729 24732377 Down regulation of miR 141 induced by helicobacter pylori promotes the invasion of gastric cancer by targeting STAT4; A luciferase assay revealed that miR-141 was directly bound to the 3'-untranslated regions 3'-UTR of STAT4; Over-expression of STAT4 was used to mimic miR-141 action in the invasion of gastric cancer; MiR-141 may play a pivotal role in controlling gastric cancer invasion through regulating STAT4 and maybe a potential target to treat gastric cancer gastric cancer hsa-miR-200a-3p STAT4 0.717826667295984 0.193912116506827 0.402913849290048 0.351234544078014 MirTarget -0.143223472247308 0.00992055939647433 NA NA NA hsa-miR-141-3p STAT5A 1.45548825076434 0.00115958850961764 0.171948091572721 0.547041277288251 MirTarget;TargetScan;miRNATAP -0.13819145026373 0.00191899177533595 25241899 Progesterone downregulation of miR 141 contributes to expansion of stem like breast cancer cells through maintenance of progesterone receptor and Stat5a; miR-141 directly targeted both PR and signal transducer and activator of transcription 5A Stat5a transcription factors important for MaSC expansion; These data support a mechanism by which P4-triggered loss of miR-141 facilitates breast cancer cell de-differentiation through deregulation of PR and Stat5a two transcription factors important for controlling mammary cell fate differentiation breast cancer hsa-miR-452-5p STAT5A 2.08756506185889 0.000258095769002813 0.171948091572721 0.547041277288251 MirTarget;miRNATAP -0.20381449641315 1.23414696840261e-09 NA NA NA hsa-miR-125a-3p STAT5B 1.19506542853853 0.00164364545717311 -0.521528133999563 0.000882266282887216 miRanda -0.101684424934139 0.000529471244936979 NA NA NA hsa-miR-141-3p STAT5B 1.45548825076434 0.00115958850961764 -0.521528133999563 0.000882266282887216 MirTarget;TargetScan;miRNATAP -0.147489664293668 4.88834798210723e-10 NA NA NA hsa-miR-185-3p STAT5B 1.33711019171256 3.45756583967985e-05 -0.521528133999563 0.000882266282887216 MirTarget -0.183735689074637 2.88601190015978e-08 NA NA NA hsa-miR-20a-3p STAT5B 1.13957127410163 0.000451087640268489 -0.521528133999563 0.000882266282887216 miRNATAP -0.136744131443289 5.03102039560139e-05 NA NA NA hsa-miR-21-3p STAT5B 1.75245546017565 2.36505176715025e-10 -0.521528133999563 0.000882266282887216 MirTarget -0.101061132163796 0.00932274067353206 NA NA NA hsa-miR-23a-3p STAT5B 1.10685926969665 3.16223452471768e-08 -0.521528133999563 0.000882266282887216 MirTarget;miRNATAP -0.339869484890937 1.16549712895063e-10 NA NA NA hsa-miR-3065-5p STAT5B -0.241623656423063 0.633116553078159 -0.521528133999563 0.000882266282887216 mirMAP -0.102233719771323 4.36701639941945e-06 NA NA NA hsa-miR-324-3p STAT5B 1.04940352369965 0.000387716796520961 -0.521528133999563 0.000882266282887216 miRNAWalker2_validate -0.160218204785756 1.49527261402499e-05 NA NA NA hsa-miR-450b-5p STAT5B 0.46157963033014 0.13273722727895 -0.521528133999563 0.000882266282887216 miRNATAP -0.118118175018694 0.00120253848100312 NA NA NA hsa-miR-590-3p STAT5B 1.11654983899947 0.000160782154924864 -0.521528133999563 0.000882266282887216 miRanda -0.180908841293277 7.96643363786385e-07 NA NA NA hsa-miR-877-5p STAT5B 2.17859965442336 1.03593450648516e-07 -0.521528133999563 0.000882266282887216 MirTarget -0.10047694807782 0.000123471006993564 NA NA NA hsa-miR-93-3p STAT5B 1.88964231421793 1.80075645722786e-08 -0.521528133999563 0.000882266282887216 miRNAWalker2_validate -0.140170987167583 9.80256725815902e-06 NA NA NA hsa-let-7a-2-3p STAT6 0.195895719455896 0.643556335039042 -0.105095816116434 0.507991139675266 MirTarget -0.105357793003293 7.43104564972916e-05 NA NA NA hsa-miR-130b-5p TPO 0.701350393759937 0.0510142718395002 -2.86160702086124 7.74975306601133e-05 mirMAP -0.78431848970234 3.25079129011077e-08 NA NA NA hsa-miR-19a-3p TPO 1.26669687448473 0.000105972838514412 -2.86160702086124 7.74975306601133e-05 mirMAP -0.903026052399198 3.88452193130535e-09 NA NA NA hsa-miR-19b-3p TPO 0.759818275708988 0.00652779573186786 -2.86160702086124 7.74975306601133e-05 mirMAP -0.96414274815251 1.48843255229884e-07 NA NA NA hsa-miR-25-3p TPO 1.00604871526544 0.000421838061147906 -2.86160702086124 7.74975306601133e-05 mirMAP -0.665183244021314 0.000250279227099771 NA NA NA hsa-miR-29a-5p TPO 0.585084040404152 0.023014129158495 -2.86160702086124 7.74975306601133e-05 mirMAP -0.681921041120848 0.00085681410666064 NA NA NA hsa-miR-335-3p TPO 2.5197689063267 2.20084506976733e-09 -2.86160702086124 7.74975306601133e-05 mirMAP -0.661630931114378 1.07219638876207e-08 NA NA NA hsa-miR-335-5p TPO 1.59953351087307 5.56170899867314e-05 -2.86160702086124 7.74975306601133e-05 miRNAWalker2_validate -0.464137366233733 0.000326238968379687 NA NA NA hsa-miR-450b-5p TPO 0.46157963033014 0.13273722727895 -2.86160702086124 7.74975306601133e-05 mirMAP -0.682867742281216 5.96258964736232e-05 NA NA NA hsa-miR-590-3p TPO 1.11654983899947 0.000160782154924864 -2.86160702086124 7.74975306601133e-05 miRanda -0.816755485084954 2.22023796668501e-06 NA NA NA hsa-miR-615-3p TPO 2.82967143704683 3.05118423223543e-05 -2.86160702086124 7.74975306601133e-05 miRanda -0.416323398084164 6.35182527711107e-05 NA NA NA hsa-miR-7-1-3p TPO 0.709309110750947 0.0412301737463194 -2.86160702086124 7.74975306601133e-05 mirMAP -0.734288879660819 6.87144428561955e-07 NA NA NA hsa-miR-92a-3p TPO 1.2209325870225 6.8757197708107e-06 -2.86160702086124 7.74975306601133e-05 mirMAP -1.2352947875528 1.02388780286531e-11 NA NA NA hsa-miR-92b-3p TPO 1.33518446513417 1.45350885391576e-06 -2.86160702086124 7.74975306601133e-05 mirMAP -0.619577668929839 0.000816809405898218 NA NA NA hsa-miR-29a-5p TSLP 0.585084040404152 0.023014129158495 -0.0411038270930665 0.943567168331468 mirMAP -0.487037020277224 0.00250944424195893 NA NA NA hsa-miR-335-5p TSLP 1.59953351087307 5.56170899867314e-05 -0.0411038270930665 0.943567168331468 miRNAWalker2_validate -0.344218741038595 0.000711656180418554 NA NA NA hsa-miR-338-3p TSLP -0.959276231066179 0.0191473351014091 -0.0411038270930665 0.943567168331468 miRanda -0.399255431422453 5.76137867514947e-05 NA NA NA hsa-miR-577 TSLP 0.911619788986754 0.2256062124148 -0.0411038270930665 0.943567168331468 PITA -0.223201239277682 5.5841206627781e-05 NA NA NA