miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-21-5p AKT2 1.51084295924322 1.54551622173259e-34 -0.343608685894869 1.25471482871759e-05 miRNAWalker2_validate -0.246625533117166 4.43585626011661e-19 NA NA NA hsa-miR-330-5p AKT2 0.442231058604099 0.0053308560843808 -0.343608685894869 1.25471482871759e-05 miRanda -0.10429759179516 1.49133299948889e-05 NA NA NA hsa-miR-342-3p AKT2 -0.319677314984262 0.0449813878317147 -0.343608685894869 1.25471482871759e-05 mirMAP -0.124944719707983 1.72780303356483e-07 NA NA NA hsa-miR-106b-5p AKT3 0.648901865047099 8.24870862047885e-09 -0.658799312069129 0.000471762262250455 miRNATAP -0.257549207275002 0.00147770551388523 NA NA NA hsa-miR-107 AKT3 0.241662461253461 0.0170788899505389 -0.658799312069129 0.000471762262250455 PITA;miRanda -0.603074134996255 1.95007791380395e-11 NA NA NA hsa-miR-122-5p AKT3 -1.23907441373955 4.42181244888642e-06 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase -0.282597613468804 3.13172096832783e-18 24244539 miR 122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3; Here we identify AKT3 as a novel and direct target of miR-122; Restoration of miR-122 expression in HCC cell lines decreases AKT3 levels inhibits cell migration and proliferation and induces apoptosis; These anti-tumor phenotypes can be rescued by reconstitution of AKT3 expression indicating the essential role of AKT3 in miR-122 mediated HCC transformation; Our data strongly suggest that miR-122 is a tumor suppressor that targets AKT3 to regulate tumorigenesis in HCCs and a potential therapeutic candidate for liver cancer tumorigenesis;cell migration liver cancer hsa-miR-146b-5p AKT3 0.419719546795449 0.0457375823220155 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate -0.159678144375669 0.000263366078999813 NA NA NA hsa-miR-15a-5p AKT3 0.349521211668244 0.000770735998804736 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265425410812535 0.00291348888530609 NA NA NA hsa-miR-17-3p AKT3 0.410352776142368 0.00422200500748636 -0.658799312069129 0.000471762262250455 miRNATAP -0.350392140268267 3.46133659001702e-08 NA NA NA hsa-miR-17-5p AKT3 0.698861147045461 2.43854106455398e-05 -0.658799312069129 0.000471762262250455 TargetScan;miRNATAP -0.290786763807918 1.04942988053081e-07 NA NA NA hsa-miR-20a-5p AKT3 0.854326758727003 5.04256669663285e-07 -0.658799312069129 0.000471762262250455 miRNATAP -0.294574079686222 2.60181650003526e-08 NA NA NA hsa-miR-32-3p AKT3 0.219109440121582 0.207217051619543 -0.658799312069129 0.000471762262250455 mirMAP -0.225932925933496 3.62088303609835e-05 NA NA NA hsa-miR-33a-3p AKT3 -0.683025859637737 1.01106097756419e-05 -0.658799312069129 0.000471762262250455 mirMAP -0.229716914608906 0.000100074832030455 NA NA NA hsa-miR-362-3p AKT3 0.814007335895913 2.00108618836568e-09 -0.658799312069129 0.000471762262250455 miRanda -0.223301194831745 0.00083465748836002 NA NA NA hsa-miR-362-5p AKT3 0.717921690799312 1.68392734504524e-05 -0.658799312069129 0.000471762262250455 PITA;TargetScan;miRNATAP -0.147261080417749 0.00734435768679755 NA NA NA hsa-miR-374a-5p AKT3 0.016390363747302 0.869784217438621 -0.658799312069129 0.000471762262250455 mirMAP -0.277843537840681 0.00293899073092604 NA NA NA hsa-miR-502-3p AKT3 0.659598854007546 3.01316453996423e-08 -0.658799312069129 0.000471762262250455 miRNATAP -0.256952206617794 0.000795069967308112 NA NA NA hsa-miR-616-5p AKT3 0.150569904638223 0.402836556304524 -0.658799312069129 0.000471762262250455 mirMAP -0.200000357827185 9.73725948226915e-05 NA NA NA hsa-miR-93-5p AKT3 1.39518349670953 2.84167728726712e-25 -0.658799312069129 0.000471762262250455 miRNATAP -0.283992832133781 1.04884093066001e-05 NA NA NA hsa-miR-330-5p BCL2L1 0.442231058604099 0.0053308560843808 0.0225608953357561 0.827445946886033 PITA;miRanda;miRNATAP -0.154730615864034 7.70545597695822e-07 NA NA NA hsa-miR-342-3p BCL2L1 -0.319677314984262 0.0449813878317147 0.0225608953357561 0.827445946886033 PITA;miRanda;miRNATAP -0.123843624743073 7.98408137042515e-05 NA NA NA hsa-miR-342-5p BCL2L1 -0.780720763816797 5.21703298730986e-07 0.0225608953357561 0.827445946886033 miRNATAP -0.106591893041378 0.000835493298714261 NA NA NA hsa-miR-484 BCL2L1 0.0857240033709656 0.453982056282229 0.0225608953357561 0.827445946886033 miRNAWalker2_validate -0.214137045460272 1.02827848229123e-06 NA NA NA hsa-miR-192-5p CBL -0.50188499512787 0.00344713341196035 0.0549640409712908 0.654706328872111 mirMAP -0.235199499067807 3.95863847644446e-12 NA NA NA hsa-miR-22-3p CBL -0.628561621952407 1.33755558015523e-09 0.0549640409712908 0.654706328872111 MirTarget -0.291142747541843 2.34921546506491e-07 NA NA NA hsa-miR-29c-3p CBL -1.4367517608807 1.61767774905781e-21 0.0549640409712908 0.654706328872111 mirMAP -0.10899286694415 0.00381986136405013 NA NA NA hsa-miR-618 CBL 0.13539895350352 0.517145913114103 0.0549640409712908 0.654706328872111 mirMAP -0.12187112095799 3.5131385547825e-05 NA NA NA hsa-miR-106a-5p CCND1 -0.464229535269236 0.009724944358047 -0.901747452525989 1.22363850855738e-05 MirTarget;miRNATAP -0.262282596122017 2.76721397734651e-06 NA NA NA hsa-miR-106b-5p CCND1 0.648901865047099 8.24870862047885e-09 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.430796355484411 1.07010119372681e-06 NA NA NA hsa-miR-1266-5p CCND1 1.6344248374643 4.09278929749906e-13 -0.901747452525989 1.22363850855738e-05 MirTarget -0.234489057674296 5.64471200142146e-08 NA NA NA hsa-miR-15b-5p CCND1 0.230566941413564 0.0824765001857479 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.544455359613115 3.17021042565567e-13 NA NA NA hsa-miR-16-5p CCND1 -0.398577235179603 0.000101598495180191 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.309506657035983 0.00178218906910022 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-17-5p CCND1 0.698861147045461 2.43854106455398e-05 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.343463418912801 9.97512783987264e-09 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-186-5p CCND1 -0.060103391373687 0.535288717081205 -0.901747452525989 1.22363850855738e-05 mirMAP -0.315936974513477 0.00286438511586306 NA NA NA hsa-miR-19a-3p CCND1 1.01712596153672 2.57753201450625e-07 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.283475432466515 1.38758823633513e-08 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 -0.277804782598538 0.0783067794722916 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase -0.307712037252966 1.4364183273616e-06 NA NA NA hsa-miR-19b-3p CCND1 0.601279551368824 0.00016685097085251 -0.901747452525989 1.22363850855738e-05 miRNATAP -0.340975400639976 4.6454998539434e-08 NA NA NA hsa-miR-20a-5p CCND1 0.854326758727003 5.04256669663285e-07 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.332506713675419 1.04479750525145e-08 NA NA NA hsa-miR-20b-5p CCND1 0.457668023910379 0.0285865211936156 -0.901747452525989 1.22363850855738e-05 MirTarget;miRNATAP -0.230429652941375 1.603682834845e-06 NA NA NA hsa-miR-340-5p CCND1 -0.00477614531381576 0.968502722773791 -0.901747452525989 1.22363850855738e-05 mirMAP -0.322810275002772 0.000125999869952101 NA NA NA hsa-miR-425-5p CCND1 0.585974239943864 2.23063410931402e-05 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate -0.385144136522737 9.38557217850495e-08 NA NA NA hsa-miR-503-5p CCND1 0.191949282338049 0.268420664548092 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.155187994375291 0.00815133470022587 26047605;23731275 MiR 503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression; Overexpression of miR-503 in breast cancer cell lines reduced cell proliferation through inducing G0/G1 cell cycle arrest by targeting CCND1;MicroRNA 503 suppresses proliferation and cell cycle progression of endometrioid endometrial cancer by negatively regulating cyclin D1; CCND1 has a binding sequence of miR-503 within its 3' untranslated region and was confirmed to be a direct target of miR-503 by the fluorescent reporter assays; Increasing the miR-503 level in EEC cells suppressed cell viability colon formation activity and cell-cycle progression and the inhibited oncogenic phenotypes induced by miR-503 were alleviated by ectopic expression of CCND1 without the untranslated region sequence; Collectively this study suggested that miR-503 plays a tumor-suppressor role by targeting CCND1; Abnormal suppression of miR-503 leads to an increase in the CCND1 level which may promote carcinogenesis and progression of EEC ;progression;tumorigenesis breast cancer;endometrial cancer hsa-miR-589-3p CCND1 1.16846704028095 5.88525574424201e-11 -0.901747452525989 1.22363850855738e-05 MirTarget -0.183119037529565 0.00124255651400669 NA NA NA hsa-miR-616-5p CCND1 0.150569904638223 0.402836556304524 -0.901747452525989 1.22363850855738e-05 mirMAP -0.256039244652268 5.24430962347992e-06 NA NA NA hsa-miR-7-1-3p CCND1 -0.569105143287799 1.85297665041424e-05 -0.901747452525989 1.22363850855738e-05 mirMAP -0.260985322289835 0.000573950021646959 NA NA NA hsa-miR-9-5p CCND1 1.26407994492898 8.53156156439881e-05 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate -0.136746717035529 1.04306605002938e-05 NA NA NA hsa-miR-92a-3p CCND1 0.212391012518195 0.134292268089997 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate -0.407898716180535 8.06773614790968e-09 NA NA NA hsa-miR-93-5p CCND1 1.39518349670953 2.84167728726712e-25 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.335918242999821 2.01286203755089e-06 NA NA NA hsa-miR-942-5p CCND1 0.346451845105263 0.0283255399972342 -0.901747452525989 1.22363850855738e-05 MirTarget -0.245807225430864 0.000123103109119178 NA NA NA hsa-miR-130b-5p CCND2 0.170599813152408 0.337611586432771 0.356451160382274 0.0365641518216489 mirMAP -0.174593683703476 0.000182311423622 NA NA NA hsa-miR-20a-5p CCND2 0.854326758727003 5.04256669663285e-07 0.356451160382274 0.0365641518216489 miRNAWalker2_validate;miRTarBase;miRNATAP -0.156120931730772 0.0012098497067071 NA NA NA hsa-miR-28-5p CCND2 -0.430964830599964 2.67367257252925e-06 0.356451160382274 0.0365641518216489 miRanda -0.482733599739849 7.0104175669049e-08 NA NA NA hsa-miR-33a-3p CCND2 -0.683025859637737 1.01106097756419e-05 0.356451160382274 0.0365641518216489 MirTarget -0.263538375258973 6.17940317063527e-07 NA NA NA hsa-miR-3607-3p CCND2 -2.15518588554493 1.03390728226728e-23 0.356451160382274 0.0365641518216489 mirMAP -0.12362922199284 0.000700039964538526 NA NA NA hsa-miR-378a-3p CCND2 -1.1920055906972 3.23538871733634e-10 0.356451160382274 0.0365641518216489 miRNAWalker2_validate -0.183441253857915 1.70039721501862e-05 NA NA NA hsa-miR-548v CCND2 -0.27258775900243 0.176259917595269 0.356451160382274 0.0365641518216489 MirTarget -0.149460521918892 0.000339780804187451 NA NA NA hsa-miR-616-5p CCND2 0.150569904638223 0.402836556304524 0.356451160382274 0.0365641518216489 mirMAP -0.315443515897926 3.35063962863299e-12 NA NA NA hsa-miR-618 CCND2 0.13539895350352 0.517145913114103 0.356451160382274 0.0365641518216489 mirMAP -0.225947558771367 2.79586020953898e-08 NA NA NA hsa-miR-27b-3p CCND3 -0.823491817819754 9.20935302746823e-14 0.0767102129984094 0.478427267753328 miRNAWalker2_validate -0.236832359235505 2.50262257150465e-07 NA NA NA hsa-miR-320a CCND3 0.325285936317332 0.0221415065838824 0.0767102129984094 0.478427267753328 miRanda -0.118523664136384 0.00134906533817398 NA NA NA hsa-miR-324-5p CISH 0.372933276649782 0.00592280066108904 -1.21545306902279 1.14842571587541e-11 miRanda -0.21620758500388 0.0010590521049028 NA NA NA hsa-miR-21-5p CNTFR 1.51084295924322 1.54551622173259e-34 -3.51076939120689 5.09275920906821e-11 miRNATAP -1.10448148913803 2.07872949243695e-08 NA NA NA hsa-miR-589-5p CNTFR 1.18593770505086 1.01781241960531e-22 -3.51076939120689 5.09275920906821e-11 miRNATAP -0.730928605605511 0.000490815420114844 NA NA NA hsa-miR-324-3p CREBBP 0.260348469146494 0.0506141704203545 -0.198953226514463 0.0138678371438249 miRNAWalker2_validate -0.122219674872295 3.31240083157391e-05 NA NA NA hsa-miR-330-5p CREBBP 0.442231058604099 0.0053308560843808 -0.198953226514463 0.0138678371438249 miRanda -0.10760918491025 1.18364633640293e-05 NA NA NA hsa-miR-769-5p CREBBP 0.219661452072771 0.0333425465750576 -0.198953226514463 0.0138678371438249 miRNAWalker2_validate -0.128844707446474 0.00077006671697313 NA NA NA hsa-miR-19a-3p CSF2RB 1.01712596153672 2.57753201450625e-07 -0.510057706101157 0.00683192745956236 MirTarget -0.120533382582832 0.00885126081922571 NA NA NA hsa-miR-19b-3p CSF2RB 0.601279551368824 0.00016685097085251 -0.510057706101157 0.00683192745956236 MirTarget -0.154504842048333 0.0071335754861484 NA NA NA hsa-miR-204-5p CSF2RB -0.537962150012103 0.0330895493358849 -0.510057706101157 0.00683192745956236 MirTarget -0.111334390280645 0.00224060172110844 NA NA NA hsa-miR-30b-3p CSF2RB -0.439724365151373 0.000947180503583586 -0.510057706101157 0.00683192745956236 MirTarget -0.201103593319895 0.00366034123496103 NA NA NA hsa-miR-455-5p CSF2RB -0.270546034117157 0.0581320703577731 -0.510057706101157 0.00683192745956236 miRanda -0.37382538214599 4.3712193850043e-09 NA NA NA hsa-miR-532-5p CSF2RB 1.02729546510601 9.93318913966636e-16 -0.510057706101157 0.00683192745956236 MirTarget -0.3331966059366 1.42783661157539e-06 NA NA NA hsa-miR-339-5p EP300 0.280589919878422 0.0355660282647215 -0.200382966790078 0.0704945874784134 miRanda -0.157358640254018 9.53193539159902e-05 NA NA NA hsa-miR-342-3p EP300 -0.319677314984262 0.0449813878317147 -0.200382966790078 0.0704945874784134 MirTarget;PITA;miRanda;miRNATAP -0.112632997815777 0.000853079257159957 NA NA NA hsa-let-7e-5p GHR 0.0350298755544731 0.811068614727804 -3.0731350188505 2.37156410493146e-28 miRNATAP -0.377255073576678 0.000145575955630923 NA NA NA hsa-miR-15a-5p GHR 0.349521211668244 0.000770735998804736 -3.0731350188505 2.37156410493146e-28 MirTarget;miRNATAP -0.550186371213254 8.39585599580478e-05 NA NA NA hsa-miR-29a-5p GHR -0.113555908626946 0.349622266470788 -3.0731350188505 2.37156410493146e-28 mirMAP;miRNATAP -0.363891052104852 0.00254054547194364 NA NA NA hsa-miR-361-5p GHR 0.233202959858696 0.00961572812255327 -3.0731350188505 2.37156410493146e-28 miRanda -0.686703580148507 2.33974492023957e-05 NA NA NA hsa-miR-421 GHR 0.941856334694081 6.12167297054077e-08 -3.0731350188505 2.37156410493146e-28 miRanda -0.75730282604987 6.46899530113514e-22 NA NA NA hsa-miR-361-5p IFNAR1 0.233202959858696 0.00961572812255327 -0.792062674909203 2.09239032499642e-23 miRanda -0.157033852704188 0.00059042956108057 NA NA NA hsa-miR-3913-5p IFNAR1 0.247553671224336 0.062795011081188 -0.792062674909203 2.09239032499642e-23 mirMAP -0.126885674032461 3.57212494027152e-05 NA NA NA hsa-miR-181b-5p IFNGR1 0.488256489401108 0.00105321129419701 -0.35955884207507 0.0116826908041428 miRNAWalker2_validate -0.265113774857758 7.56869583693282e-09 NA NA NA hsa-miR-362-3p IFNGR1 0.814007335895913 2.00108618836568e-09 -0.35955884207507 0.0116826908041428 miRanda -0.131201813029045 0.00936823631284447 NA NA NA hsa-miR-26b-5p IFNGR2 -1.10804856399744 4.14176110314282e-22 0.12939134789993 0.222921760917437 miRNAWalker2_validate -0.130364145038162 0.00237891298523041 NA NA NA hsa-miR-455-5p IL10RA -0.270546034117157 0.0581320703577731 -0.991152842155614 4.01017794079741e-08 miRanda -0.295628807328655 2.03411461989517e-06 NA NA NA hsa-miR-326 IL11RA -1.881935132554 1.68087316863775e-21 0.132400493828192 0.313269790428285 miRanda -0.112070852902402 0.000286014789799609 NA NA NA hsa-miR-330-5p IL11RA 0.442231058604099 0.0053308560843808 0.132400493828192 0.313269790428285 miRanda -0.192652008930302 1.3055885628378e-06 NA NA NA hsa-miR-455-5p IL12RB1 -0.270546034117157 0.0581320703577731 -0.723342262361193 0.00084365969926356 miRanda -0.336272780541351 5.48057159106083e-06 NA NA NA hsa-miR-338-3p IL12RB2 0.543135607704581 0.00461167747143826 -0.414456183002348 0.103212145057214 miRanda -0.195606063425154 0.002400044074527 NA NA NA hsa-miR-128-3p IL13RA1 0.289735108018712 0.0114419474207889 -0.704314818990906 8.76398316875394e-11 MirTarget -0.129148934110705 0.0064547337337291 NA NA NA hsa-miR-16-2-3p IL13RA1 -0.0336420826463706 0.805158952566973 -0.704314818990906 8.76398316875394e-11 MirTarget -0.1866474785252 2.30826371258753e-06 NA NA NA hsa-miR-181a-2-3p IL13RA1 -0.232005557505191 0.236404981276858 -0.704314818990906 8.76398316875394e-11 MirTarget -0.14791210117915 5.72643559392563e-08 NA NA NA hsa-miR-185-5p IL13RA1 0.480006257154717 6.35758891340152e-07 -0.704314818990906 8.76398316875394e-11 MirTarget -0.146289543758741 0.00899372657634814 NA NA NA hsa-miR-188-5p IL13RA1 1.11646899351496 9.56686958408598e-11 -0.704314818990906 8.76398316875394e-11 MirTarget;miRNATAP -0.161955064951671 9.56602460195466e-08 NA NA NA hsa-miR-324-5p IL13RA1 0.372933276649782 0.00592280066108904 -0.704314818990906 8.76398316875394e-11 miRanda -0.206904317238823 1.58104500429679e-07 NA NA NA hsa-miR-330-3p IL13RA1 -0.332364259424489 0.0316051913061459 -0.704314818990906 8.76398316875394e-11 MirTarget;PITA;miRNATAP -0.128870021925486 0.00030404853009185 NA NA NA hsa-miR-331-3p IL13RA1 -0.283974346994635 0.0373785411053202 -0.704314818990906 8.76398316875394e-11 MirTarget -0.131680507006734 0.000899614047467102 NA NA NA hsa-miR-331-5p IL13RA1 0.213759185384356 0.120772399478646 -0.704314818990906 8.76398316875394e-11 miRNATAP -0.237033703473624 1.12691984283011e-09 NA NA NA hsa-miR-338-5p IL13RA1 -0.221898432884726 0.252390988727086 -0.704314818990906 8.76398316875394e-11 MirTarget;PITA -0.125631561855211 6.45453160395849e-06 NA NA NA hsa-miR-421 IL13RA1 0.941856334694081 6.12167297054077e-08 -0.704314818990906 8.76398316875394e-11 miRanda -0.117757302831122 0.000119818154932068 NA NA NA hsa-miR-148b-3p IL13RA2 0.266862251671911 0.00185271302045935 -4.49130914752795 6.299897559854e-32 miRNAWalker2_validate -0.798031428348919 0.000768039972605932 NA NA NA hsa-miR-107 IL15 0.241662461253461 0.0170788899505389 -0.299033597604689 0.133566104518099 miRanda;miRNATAP -0.558377313339206 4.35121973873231e-09 NA NA NA hsa-miR-148a-3p IL15 -0.748702855596996 3.93313343865641e-07 -0.299033597604689 0.133566104518099 MirTarget -0.360950562564519 1.84990625247238e-08 NA NA NA hsa-miR-192-5p IL15 -0.50188499512787 0.00344713341196035 -0.299033597604689 0.133566104518099 miRNAWalker2_validate -0.307919878200709 3.2482224824806e-08 NA NA NA hsa-miR-19a-3p IL15 1.01712596153672 2.57753201450625e-07 -0.299033597604689 0.133566104518099 MirTarget -0.169187617208509 0.000469880891066932 NA NA NA hsa-miR-19b-3p IL15 0.601279551368824 0.00016685097085251 -0.299033597604689 0.133566104518099 MirTarget -0.248280940020467 3.69036895748539e-05 NA NA NA hsa-miR-374a-5p IL20RA 0.016390363747302 0.869784217438621 -3.18989287028027 3.221284317688e-12 mirMAP -0.849689041651682 0.000241606785554706 NA NA NA hsa-miR-374b-5p IL20RA -0.307538028546424 0.0030079617545972 -3.18989287028027 3.221284317688e-12 mirMAP -0.636701618564179 0.00422476665411547 NA NA NA hsa-miR-664a-3p IL20RA 0.485807855553031 0.000732553249798598 -3.18989287028027 3.221284317688e-12 MirTarget;mirMAP -0.526865767056349 0.000911156921601431 NA NA NA hsa-miR-107 IL6 0.241662461253461 0.0170788899505389 -2.0069298945737 2.33900822782796e-09 miRanda -0.962941107019514 4.00052775475113e-09 NA NA NA hsa-miR-361-5p IL6 0.233202959858696 0.00961572812255327 -2.0069298945737 2.33900822782796e-09 miRanda -0.746870831233242 6.34041923472147e-05 NA NA NA hsa-miR-365a-3p IL6 0.164591326307714 0.15325084963213 -2.0069298945737 2.33900822782796e-09 miRNAWalker2_validate -0.508496672954192 0.000482261146415095 NA NA NA hsa-let-7e-5p IL6R 0.0350298755544731 0.811068614727804 -0.197357669964791 0.382548993653367 miRNATAP -0.311334738219198 3.31955081908111e-05 NA NA NA hsa-let-7i-5p IL6R -0.14267936165213 0.154141689875847 -0.197357669964791 0.382548993653367 miRNATAP -0.443175862594576 6.10806225986565e-05 NA NA NA hsa-miR-103a-2-5p IL6R 1.17085533927423 5.31418969120877e-09 -0.197357669964791 0.382548993653367 mirMAP -0.15359917006386 0.0067292715186963 NA NA NA hsa-miR-125a-5p IL6R -0.91219969372382 1.38256246489548e-07 -0.197357669964791 0.382548993653367 MirTarget;miRanda -0.238025357559185 0.000137274290397462 NA NA NA hsa-miR-130a-3p IL6R -1.53229181736223 2.91460363624872e-19 -0.197357669964791 0.382548993653367 mirMAP -0.200690702363128 0.00110575859685919 NA NA NA hsa-miR-141-3p IL6R -0.354316381352484 0.256996894288799 -0.197357669964791 0.382548993653367 MirTarget -0.142554332435554 4.93408139054963e-05 NA NA NA hsa-miR-141-5p IL6R -0.499951322764425 0.102654772628289 -0.197357669964791 0.382548993653367 MirTarget -0.117434701677051 0.00140254269544032 NA NA NA hsa-miR-155-5p IL6R 0.0108524225071784 0.95651331033505 -0.197357669964791 0.382548993653367 MirTarget -0.277627367207754 4.05000284880467e-07 NA NA NA hsa-miR-182-5p IL6R 1.96601340710222 4.39326175603633e-09 -0.197357669964791 0.382548993653367 mirMAP -0.141778275229433 9.03668122661657e-06 NA NA NA hsa-miR-200a-3p IL6R -1.49949292595657 3.18410995256133e-05 -0.197357669964791 0.382548993653367 MirTarget -0.159850426034774 9.36193333495953e-08 NA NA NA hsa-miR-21-5p IL6R 1.51084295924322 1.54551622173259e-34 -0.197357669964791 0.382548993653367 MirTarget;miRNATAP -0.536139043119449 2.87865737326418e-11 NA NA NA hsa-miR-23a-3p IL6R -0.178875974460574 0.135978273540604 -0.197357669964791 0.382548993653367 miRNAWalker2_validate;miRTarBase;MirTarget -0.476455604733452 1.77513645727087e-07 NA NA NA hsa-miR-301a-3p IL6R 0.842910511640361 1.43446467417891e-06 -0.197357669964791 0.382548993653367 mirMAP -0.270231870208627 1.2309199906437e-05 NA NA NA hsa-miR-30b-5p IL6R -0.54056186708617 2.44688760798341e-05 -0.197357669964791 0.382548993653367 mirMAP -0.341317440343868 6.08305739490161e-05 NA NA NA hsa-miR-330-3p IL6R -0.332364259424489 0.0316051913061459 -0.197357669964791 0.382548993653367 miRNATAP -0.395044882587144 3.93410619382339e-08 NA NA NA hsa-miR-331-3p IL6R -0.283974346994635 0.0373785411053202 -0.197357669964791 0.382548993653367 MirTarget -0.272591937902894 0.000734050937687351 NA NA NA hsa-miR-421 IL6R 0.941856334694081 6.12167297054077e-08 -0.197357669964791 0.382548993653367 mirMAP -0.184999766620453 0.00310315621875882 NA NA NA hsa-miR-501-5p IL6R 1.15231083477882 2.98906150004088e-10 -0.197357669964791 0.382548993653367 miRNATAP -0.18254438194728 0.00194179348124099 NA NA NA hsa-miR-103a-3p IL6ST 0.765568928457606 3.05497476509383e-12 -1.91925864959166 1.59476897276323e-08 mirMAP -0.667446753690743 8.00185441607647e-06 NA NA NA hsa-miR-1301-3p IL6ST 1.12156714169769 4.22404125385203e-10 -1.91925864959166 1.59476897276323e-08 MirTarget -0.337588693982326 0.000228211191141145 NA NA NA hsa-miR-130b-3p IL6ST 0.687190305027546 0.000109068658562255 -1.91925864959166 1.59476897276323e-08 miRNATAP -0.292204703220205 0.00191837670242277 NA NA NA hsa-miR-148b-5p IL6ST 0.295777213389605 0.0255749859535438 -1.91925864959166 1.59476897276323e-08 mirMAP -0.440783328461657 0.000542993457304874 NA NA NA hsa-miR-16-1-3p IL6ST 0.392360028038559 0.00112481918108198 -1.91925864959166 1.59476897276323e-08 mirMAP -0.381246621718359 0.00650997533498134 NA NA NA hsa-miR-17-5p IL6ST 0.698861147045461 2.43854106455398e-05 -1.91925864959166 1.59476897276323e-08 TargetScan -0.538298624935658 6.76871717495903e-08 NA NA NA hsa-miR-181b-5p IL6ST 0.488256489401108 0.00105321129419701 -1.91925864959166 1.59476897276323e-08 mirMAP -0.297659176110622 0.00837138676157886 NA NA NA hsa-miR-19a-3p IL6ST 1.01712596153672 2.57753201450625e-07 -1.91925864959166 1.59476897276323e-08 mirMAP;miRNATAP -0.330379861699273 8.02510325117589e-05 NA NA NA hsa-miR-19b-3p IL6ST 0.601279551368824 0.00016685097085251 -1.91925864959166 1.59476897276323e-08 mirMAP;miRNATAP -0.376995076356605 0.000315925805068915 NA NA NA hsa-miR-21-5p IL6ST 1.51084295924322 1.54551622173259e-34 -1.91925864959166 1.59476897276323e-08 mirMAP -0.643707080430308 2.44682283240179e-07 NA NA NA hsa-miR-301a-3p IL6ST 0.842910511640361 1.43446467417891e-06 -1.91925864959166 1.59476897276323e-08 mirMAP;miRNATAP -0.51713062939287 3.80453654899149e-08 NA NA NA hsa-miR-32-3p IL6ST 0.219109440121582 0.207217051619543 -1.91925864959166 1.59476897276323e-08 mirMAP -0.268019203371576 0.00760610331393608 NA NA NA hsa-miR-362-3p IL6ST 0.814007335895913 2.00108618836568e-09 -1.91925864959166 1.59476897276323e-08 PITA;miRanda;miRNATAP -0.372293350404712 0.00229654342007657 NA NA NA hsa-miR-362-5p IL6ST 0.717921690799312 1.68392734504524e-05 -1.91925864959166 1.59476897276323e-08 mirMAP -0.374312887655957 0.000177304138151157 NA NA NA hsa-miR-421 IL6ST 0.941856334694081 6.12167297054077e-08 -1.91925864959166 1.59476897276323e-08 PITA;miRanda;mirMAP -0.324569125582777 0.000689570220088528 NA NA NA hsa-miR-452-5p IL6ST 1.91544498799508 1.81995982853313e-14 -1.91925864959166 1.59476897276323e-08 mirMAP -0.221821908964667 0.000643072477252391 NA NA NA hsa-miR-455-5p IL6ST -0.270546034117157 0.0581320703577731 -1.91925864959166 1.59476897276323e-08 miRanda -0.381028018243511 0.0012613423948231 NA NA NA hsa-miR-501-5p IL6ST 1.15231083477882 2.98906150004088e-10 -1.91925864959166 1.59476897276323e-08 mirMAP -0.394321266654524 1.09835272830617e-05 NA NA NA hsa-miR-532-5p IL6ST 1.02729546510601 9.93318913966636e-16 -1.91925864959166 1.59476897276323e-08 PITA -0.586817584854707 3.52264014400389e-06 NA NA NA hsa-miR-589-3p IL6ST 1.16846704028095 5.88525574424201e-11 -1.91925864959166 1.59476897276323e-08 mirMAP -0.378866268145962 5.41046462734426e-05 NA NA NA hsa-miR-590-5p IL6ST -0.103355559980404 0.310027295317092 -1.91925864959166 1.59476897276323e-08 mirMAP -0.475392042100724 0.00449326289466456 NA NA NA hsa-miR-766-3p IL6ST 0.199979324759329 0.257230732626744 -1.91925864959166 1.59476897276323e-08 MirTarget -0.305804329853949 0.00136485271948955 NA NA NA hsa-miR-93-3p IL6ST 0.402821129107592 0.00131324842735588 -1.91925864959166 1.59476897276323e-08 MirTarget -0.544072709623523 4.78743772126621e-05 NA NA NA hsa-miR-335-3p IL7 -0.275199247483111 0.106629165248783 -0.477026521881925 0.00101915198923927 mirMAP -0.119073972112747 0.00430087219022835 NA NA NA hsa-miR-106b-5p IRF9 0.648901865047099 8.24870862047885e-09 -0.332521842154738 0.00577148745956252 miRNAWalker2_validate -0.214597503013757 2.92088699374391e-05 NA NA NA hsa-miR-17-5p IRF9 0.698861147045461 2.43854106455398e-05 -0.332521842154738 0.00577148745956252 TargetScan -0.136658630846395 9.79304907803886e-05 NA NA NA hsa-miR-106b-5p JAK1 0.648901865047099 8.24870862047885e-09 -0.491502741052473 2.21647945606145e-08 miRNAWalker2_validate;MirTarget -0.274241391983959 1.386588824919e-13 NA NA NA hsa-miR-128-3p JAK1 0.289735108018712 0.0114419474207889 -0.491502741052473 2.21647945606145e-08 miRNAWalker2_validate -0.109369528499963 0.00404231658945177 NA NA NA hsa-miR-17-5p JAK1 0.698861147045461 2.43854106455398e-05 -0.491502741052473 2.21647945606145e-08 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.268052325740918 3.25515675433912e-28 NA NA NA hsa-miR-20a-5p JAK1 0.854326758727003 5.04256669663285e-07 -0.491502741052473 2.21647945606145e-08 MirTarget -0.23386116447226 1.56734608485868e-22 NA NA NA hsa-miR-30d-5p JAK1 0.718283816348023 2.47422074061352e-08 -0.491502741052473 2.21647945606145e-08 MirTarget -0.145093822003298 1.12748945024431e-05 NA NA NA hsa-miR-455-5p JAK1 -0.270546034117157 0.0581320703577731 -0.491502741052473 2.21647945606145e-08 miRanda -0.167977882302863 2.26382130466332e-08 NA NA NA hsa-miR-93-5p JAK1 1.39518349670953 2.84167728726712e-25 -0.491502741052473 2.21647945606145e-08 MirTarget;miRNATAP -0.238027881672368 6.65509610107069e-16 NA NA NA hsa-miR-139-5p JAK3 -2.11299531796557 8.16407076415038e-28 -0.0341347925675266 0.875605617465597 miRanda -0.183410063739571 0.000335328682413109 NA NA NA hsa-miR-30b-3p JAK3 -0.439724365151373 0.000947180503583586 -0.0341347925675266 0.875605617465597 MirTarget -0.298822167939758 0.000168370600584498 NA NA NA hsa-miR-616-5p JAK3 0.150569904638223 0.402836556304524 -0.0341347925675266 0.875605617465597 MirTarget -0.275006451227061 2.84326544589298e-06 NA NA NA hsa-miR-16-1-3p LEPR 0.392360028038559 0.00112481918108198 -1.83584567635751 5.92773100787479e-09 mirMAP -0.446552305847479 0.000590321672294901 NA NA NA hsa-miR-16-2-3p LEPR -0.0336420826463706 0.805158952566973 -1.83584567635751 5.92773100787479e-09 mirMAP -0.344095586451788 0.00288441551676892 NA NA NA hsa-miR-23a-3p LEPR -0.178875974460574 0.135978273540604 -1.83584567635751 5.92773100787479e-09 mirMAP -0.500204336391853 0.000133332454981355 NA NA NA hsa-miR-330-5p LEPR 0.442231058604099 0.0053308560843808 -1.83584567635751 5.92773100787479e-09 miRanda -0.497422623359451 3.43749737677974e-07 NA NA NA hsa-miR-335-3p LEPR -0.275199247483111 0.106629165248783 -1.83584567635751 5.92773100787479e-09 mirMAP -0.405037513168954 9.27326368738662e-06 NA NA NA hsa-miR-342-3p LEPR -0.319677314984262 0.0449813878317147 -1.83584567635751 5.92773100787479e-09 miRanda -0.34689220777985 0.000407353071623409 NA NA NA hsa-miR-362-3p LEPR 0.814007335895913 2.00108618836568e-09 -1.83584567635751 5.92773100787479e-09 miRanda -0.329179706781453 0.00376406372885643 NA NA NA hsa-miR-421 LEPR 0.941856334694081 6.12167297054077e-08 -1.83584567635751 5.92773100787479e-09 miRanda -0.486627316529398 3.13187830982235e-08 NA NA NA hsa-miR-429 LEPR -1.40262535827285 6.93982219171912e-05 -1.83584567635751 5.92773100787479e-09 miRanda;miRNATAP -0.255399604524905 6.02825127159829e-09 NA NA NA hsa-miR-660-5p LEPR 0.989755850734071 5.69930767464937e-14 -1.83584567635751 5.92773100787479e-09 MirTarget -0.508506970653067 9.70076868934312e-06 NA NA NA hsa-miR-877-5p LEPR 1.35669625926821 1.43008125755656e-11 -1.83584567635751 5.92773100787479e-09 miRNAWalker2_validate -0.58521090877089 3.70253542544936e-14 NA NA NA hsa-miR-125b-5p LIF -1.35767721102906 1.16564617395164e-18 -0.722255918484923 0.0325743370034823 miRNAWalker2_validate;mirMAP -0.288066949249382 0.00505129146137661 NA NA NA hsa-miR-204-5p LIF -0.537962150012103 0.0330895493358849 -0.722255918484923 0.0325743370034823 mirMAP -0.326349574327953 4.36768021106133e-07 NA NA NA hsa-miR-20a-5p LIF 0.854326758727003 5.04256669663285e-07 -0.722255918484923 0.0325743370034823 miRNATAP -0.249921952355473 0.00917214825956543 NA NA NA hsa-miR-28-5p LIF -0.430964830599964 2.67367257252925e-06 -0.722255918484923 0.0325743370034823 miRNATAP -0.848697072354536 1.94865292386491e-06 NA NA NA hsa-miR-455-3p LIF -1.3998033821095 5.72010709806871e-17 -0.722255918484923 0.0325743370034823 mirMAP -0.372145729781505 8.23233339597696e-05 NA NA NA hsa-miR-532-3p LIF 0.297601533259956 0.014632205884815 -0.722255918484923 0.0325743370034823 mirMAP -0.406883960810845 0.00272714718151025 NA NA NA hsa-miR-616-5p LIF 0.150569904638223 0.402836556304524 -0.722255918484923 0.0325743370034823 mirMAP -0.470058485681719 2.44528499323621e-07 NA NA NA hsa-miR-128-3p LIFR 0.289735108018712 0.0114419474207889 -3.54791005337671 1.62449725318617e-42 miRNAWalker2_validate -0.377756609867129 0.0021854905726557 NA NA NA hsa-miR-182-5p LIFR 1.96601340710222 4.39326175603633e-09 -3.54791005337671 1.62449725318617e-42 mirMAP -0.153695282447375 0.000176299649114969 NA NA NA hsa-miR-19a-3p LIFR 1.01712596153672 2.57753201450625e-07 -3.54791005337671 1.62449725318617e-42 mirMAP -0.33571072570759 1.42631504836127e-06 NA NA NA hsa-miR-19b-3p LIFR 0.601279551368824 0.00016685097085251 -3.54791005337671 1.62449725318617e-42 mirMAP -0.360267832609079 3.58944375683591e-05 NA NA NA hsa-miR-21-5p LIFR 1.51084295924322 1.54551622173259e-34 -3.54791005337671 1.62449725318617e-42 miRNAWalker2_validate -0.970873248845757 3.02875243005404e-22 NA NA NA hsa-miR-221-3p LIFR 1.12244756358612 3.48370308238012e-13 -3.54791005337671 1.62449725318617e-42 miRNATAP -0.543309890221884 4.42342545438935e-10 NA NA NA hsa-miR-222-3p LIFR 1.08574156066353 1.76407192348131e-11 -3.54791005337671 1.62449725318617e-42 miRNATAP -0.427882092016526 3.76311937486636e-07 NA NA NA hsa-miR-224-3p LIFR 1.40770116795301 1.31426607144612e-08 -3.54791005337671 1.62449725318617e-42 mirMAP -0.26591755475668 2.05976172840671e-06 NA NA NA hsa-miR-30d-5p LIFR 0.718283816348023 2.47422074061352e-08 -3.54791005337671 1.62449725318617e-42 miRNATAP -0.589382903724551 3.07043543601784e-08 NA NA NA hsa-miR-3682-3p LIFR 0.805600143458555 8.7874424633131e-06 -3.54791005337671 1.62449725318617e-42 mirMAP -0.2365671069426 0.00317654696599503 NA NA NA hsa-miR-421 LIFR 0.941856334694081 6.12167297054077e-08 -3.54791005337671 1.62449725318617e-42 mirMAP -0.341526338401473 1.75125828118573e-05 NA NA NA hsa-miR-500a-5p LIFR 0.797906382969156 9.15958171084226e-08 -3.54791005337671 1.62449725318617e-42 mirMAP -0.395610970743605 1.87409751441164e-05 NA NA NA hsa-miR-548b-3p LIFR -0.0203576084717134 0.930819503166956 -3.54791005337671 1.62449725318617e-42 miRNATAP -0.166834169912835 0.00614062189682628 NA NA NA hsa-let-7d-5p MPL 0.0503292020123807 0.702580311853671 -0.248715300490881 0.101984451680396 miRNAWalker2_validate -0.204136525483039 0.000292050444479849 NA NA NA hsa-let-7e-5p MPL 0.0350298755544731 0.811068614727804 -0.248715300490881 0.101984451680396 miRNAWalker2_validate -0.178619553218127 0.000419481970012655 NA NA NA hsa-miR-98-5p MPL -0.0487189107419432 0.715911066732548 -0.248715300490881 0.101984451680396 miRNAWalker2_validate -0.20165422791218 0.000277706633590537 NA NA NA hsa-miR-423-5p MYC 0.698807775906485 1.02195196334612e-11 -1.53204423111148 3.53987625613016e-10 miRNAWalker2_validate -0.328206409340035 0.00484551582134482 NA NA NA hsa-miR-193a-3p OSMR -0.117675551589896 0.309391958208578 -1.11763186663677 5.19656003992052e-05 MirTarget -0.322994473386268 0.00629480833244995 NA NA NA hsa-miR-193b-3p OSMR -0.166697207281748 0.272022543069482 -1.11763186663677 5.19656003992052e-05 MirTarget -0.288850457393352 0.00126926914750222 NA NA NA hsa-miR-362-3p OSMR 0.814007335895913 2.00108618836568e-09 -1.11763186663677 5.19656003992052e-05 miRanda -0.294955177086112 0.00271920470184721 NA NA NA hsa-miR-342-3p PIAS1 -0.319677314984262 0.0449813878317147 0.14110668905439 0.111009722342972 miRanda -0.127221288569843 1.97391983714843e-06 NA NA NA hsa-miR-193a-3p PIAS2 -0.117675551589896 0.309391958208578 -0.0732122819368195 0.417035467807361 MirTarget -0.104793786507245 0.00594456325421913 NA NA NA hsa-miR-328-3p PIAS3 -0.547466865311955 6.8359574451572e-06 1.0725819024204 4.08397122667349e-28 MirTarget -0.165573868536964 6.22701772703462e-05 NA NA NA hsa-miR-17-5p PIK3CA 0.698861147045461 2.43854106455398e-05 -0.417502897789422 0.000144089141837096 miRNAWalker2_validate -0.140034439363479 1.22830047865626e-05 NA NA NA hsa-miR-339-5p PIK3CA 0.280589919878422 0.0355660282647215 -0.417502897789422 0.000144089141837096 miRanda -0.161250958910826 6.10867364493006e-05 NA NA NA hsa-miR-501-5p PIK3CA 1.15231083477882 2.98906150004088e-10 -0.417502897789422 0.000144089141837096 mirMAP -0.110297544989421 0.000121810192831398 NA NA NA hsa-miR-126-5p PIK3CB -0.428561469405594 6.6035585844222e-05 0.100967159570933 0.165951003911767 mirMAP -0.182730257201379 1.71015167377407e-08 NA NA NA hsa-miR-204-5p PIK3CB -0.537962150012103 0.0330895493358849 0.100967159570933 0.165951003911767 miRNATAP -0.108408817404481 9.83805003133513e-16 NA NA NA hsa-miR-32-5p PIK3CB 0.0806126674664016 0.548984992497432 0.100967159570933 0.165951003911767 miRNATAP -0.140663620385439 6.63155819716864e-08 NA NA NA hsa-miR-1468-5p PIK3CD -1.21475558175193 2.52286949987832e-09 -0.877858532886072 2.39332269929579e-06 MirTarget -0.114605918546385 0.00956114952826845 NA NA NA hsa-miR-30b-3p PIK3CD -0.439724365151373 0.000947180503583586 -0.877858532886072 2.39332269929579e-06 MirTarget -0.241027174305288 0.000454965508091255 NA NA NA hsa-miR-30d-5p PIK3CD 0.718283816348023 2.47422074061352e-08 -0.877858532886072 2.39332269929579e-06 MirTarget;miRNATAP -0.313277633599958 7.26196135533465e-06 NA NA NA hsa-miR-30e-5p PIK3CD -0.627815042856657 3.02205690184908e-10 -0.877858532886072 2.39332269929579e-06 MirTarget -0.253648851782905 0.00528999528593308 NA NA NA hsa-miR-616-5p PIK3CD 0.150569904638223 0.402836556304524 -0.877858532886072 2.39332269929579e-06 MirTarget -0.206581353665342 5.02538338243613e-05 NA NA NA hsa-miR-103a-3p PIK3R1 0.765568928457606 3.05497476509383e-12 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.187692597616198 0.00702590214654354 NA NA NA hsa-miR-106b-5p PIK3R1 0.648901865047099 8.24870862047885e-09 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.369244291882445 4.59379549667075e-08 NA NA NA hsa-miR-1301-3p PIK3R1 1.12156714169769 4.22404125385203e-10 -0.891953424131491 1.38465728969785e-08 MirTarget -0.26088137729301 3.97606431390706e-10 NA NA NA hsa-miR-132-3p PIK3R1 0.323796239695997 0.00272093067935091 -0.891953424131491 1.38465728969785e-08 MirTarget -0.517351445825174 2.17222827385203e-13 NA NA NA hsa-miR-17-5p PIK3R1 0.698861147045461 2.43854106455398e-05 -0.891953424131491 1.38465728969785e-08 MirTarget;TargetScan;miRNATAP -0.213954808771155 3.8587060059728e-06 NA NA NA hsa-miR-185-5p PIK3R1 0.480006257154717 6.35758891340152e-07 -0.891953424131491 1.38465728969785e-08 miRNATAP -0.255181123475439 0.00153792085091181 NA NA NA hsa-miR-188-5p PIK3R1 1.11646899351496 9.56686958408598e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.178093775716465 5.33015486626271e-05 NA NA NA hsa-miR-200c-3p PIK3R1 -0.104675615392797 0.716957669484981 -0.891953424131491 1.38465728969785e-08 mirMAP -0.105107802462856 9.06963579759966e-05 NA NA NA hsa-miR-20a-5p PIK3R1 0.854326758727003 5.04256669663285e-07 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.137431012149634 0.00237710222818209 NA NA NA hsa-miR-21-5p PIK3R1 1.51084295924322 1.54551622173259e-34 -0.891953424131491 1.38465728969785e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.626634426633867 6.01244523464713e-31 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 -0.288359631986802 0.100392159518997 -0.891953424131491 1.38465728969785e-08 MirTarget -0.258090192317157 3.95293509038579e-09 NA NA NA hsa-miR-221-3p PIK3R1 1.12244756358612 3.48370308238012e-13 -0.891953424131491 1.38465728969785e-08 MirTarget -0.217914846238424 7.87055620620445e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.08574156066353 1.76407192348131e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.256619417997498 3.41697791848384e-08 NA NA NA hsa-miR-324-3p PIK3R1 0.260348469146494 0.0506141704203545 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.281792149179102 1.26555231509763e-06 NA NA NA hsa-miR-330-3p PIK3R1 -0.332364259424489 0.0316051913061459 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.212492102885122 3.44445995574159e-05 NA NA NA hsa-miR-338-5p PIK3R1 -0.221898432884726 0.252390988727086 -0.891953424131491 1.38465728969785e-08 PITA -0.143685656767977 0.000366657184559181 NA NA NA hsa-miR-409-3p PIK3R1 -0.499649792570937 0.0526751181520117 -0.891953424131491 1.38465728969785e-08 mirMAP -0.110448878014769 0.000237041711390918 NA NA NA hsa-miR-493-5p PIK3R1 -0.198321662045422 0.502870277689198 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.103739426368655 7.76271840065789e-05 NA NA NA hsa-miR-582-5p PIK3R1 -0.680189083316822 0.00103755166534107 -0.891953424131491 1.38465728969785e-08 mirMAP -0.138461163257927 0.00021364752999012 NA NA NA hsa-miR-589-3p PIK3R1 1.16846704028095 5.88525574424201e-11 -0.891953424131491 1.38465728969785e-08 mirMAP -0.21021578613876 1.13421126603334e-06 NA NA NA hsa-miR-590-5p PIK3R1 -0.103355559980404 0.310027295317092 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRanda;miRNATAP -0.299776876388425 9.9413226282672e-05 NA NA NA hsa-miR-629-3p PIK3R1 -0.315338123880353 0.119091248294946 -0.891953424131491 1.38465728969785e-08 MirTarget -0.182940394280375 3.19896248240917e-06 NA NA NA hsa-miR-93-5p PIK3R1 1.39518349670953 2.84167728726712e-25 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.319783065556515 2.89613370212511e-09 NA NA NA hsa-miR-126-3p PIK3R2 -0.652349350198172 9.37876280344772e-09 0.902461657566753 1.95242785807378e-14 miRNAWalker2_validate;miRTarBase -0.307009584408785 1.4469316595199e-09 25240815;26384552;27578985;21249429;26191164 MiR 126 3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2; LRP6 and PIK3R2 were identified as targets of miR-126-3p; Silencing LRP6 and PIK3R2 had similar effects of miR-126-3p restoration on metastasis and angiogenesis individually in HCC cells; Furthermore the miR-126-3p level was inversely correlated with LRP6 and PIK3R2 in HCC tissues; In addition the rescue experiments indicated that the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2;MicroRNA 126 suppresses proliferation of undifferentiated BRAFV600E and BRAFWT thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K AKT proliferation survival signalling pathway; In addition miR-126 was found to act as proliferation suppressor targeting PIK3R2 gene and reducing p85β a regulatory subunit of PI3K kinase protein translation and lower AKT kinase activity;MiR 126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2 mediated PI3K/Akt signaling pathway; A direct regulatory relationship between miR-126 and the PIK3R2 gene was demonstrated by luciferase reporter assays; Quantitative real-time polymerase chain reaction was used to measure miR-126 and PIK3R2 expressions; Luciferase assays showed that miR-126 significantly inhibited the PIK3R2 3' untranslated region 3'UTR luciferase reporter activity P<0.05; Overexpression of miR-126 negatively regulated the target gene PIK3R2 and further inhibited the PI3K/Akt signaling pathway thereby inhibiting proliferation migration and invasion and promoting apoptosis in BLS cells;Endothelial specific intron derived miR 126 is down regulated in human breast cancer and targets both VEGFA and PIK3R2; VEGFA and PIK3R2 were confirmed as the targets of miR-126 by luciferase reporter assay and Western blot;Restoration of miR-126 in EC109 cells induced a reduction in PIK3R2 protein levels accompanied with a substantial reduction in phosphorylated AKT levels in EC109 cells suggesting impairment in PI3K/AKT signaling pathway; The luciferase reporter assay confirmed that PIK3R2 was a direct target of miR-126; Taken together our study suggests that miR-126 functions as a potential tumor suppressor in ESCC progression via regulating PI3K/AKT signaling pathway partly by targeting PIK3R2 and targeting of miR-126 may provide a novel strategy for the diagnosis and treatment of ESCC metastasis;poor survival;;;progression liver cancer;thyroid cancer;bladder cancer;breast cancer;esophageal cancer hsa-miR-28-5p PIK3R2 -0.430964830599964 2.67367257252925e-06 0.902461657566753 1.95242785807378e-14 miRanda -0.216513318430191 0.000794318920407844 NA NA NA hsa-miR-30a-5p PIK3R2 -0.626257932887855 0.000108198196973765 0.902461657566753 1.95242785807378e-14 miRNATAP -0.144672134574065 6.66511974688791e-05 NA NA NA hsa-miR-30e-5p PIK3R2 -0.627815042856657 3.02205690184908e-10 0.902461657566753 1.95242785807378e-14 miRNATAP -0.27051427660089 3.48529317139267e-06 NA NA NA hsa-miR-3607-3p PIK3R2 -2.15518588554493 1.03390728226728e-23 0.902461657566753 1.95242785807378e-14 mirMAP;miRNATAP -0.192639313478842 2.68262287342929e-14 NA NA NA hsa-miR-19a-3p PIK3R3 1.01712596153672 2.57753201450625e-07 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.104972668125809 0.000194207587349022 NA NA NA hsa-miR-19b-3p PIK3R3 0.601279551368824 0.00016685097085251 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.156884173334155 7.42851910353984e-06 NA NA NA hsa-miR-222-5p PIK3R3 0.125716360553359 0.487423909991138 0.635454203069077 2.81455381573105e-08 mirMAP -0.124074211713995 7.25281139850942e-05 NA NA NA hsa-miR-32-5p PIK3R3 0.0806126674664016 0.548984992497432 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.115094122727672 0.00654760226880116 NA NA NA hsa-miR-331-3p PIK3R3 -0.283974346994635 0.0373785411053202 0.635454203069077 2.81455381573105e-08 miRNAWalker2_validate;PITA -0.141431444954819 0.000659359723681179 NA NA NA hsa-miR-335-3p PIK3R3 -0.275199247483111 0.106629165248783 0.635454203069077 2.81455381573105e-08 mirMAP -0.159933987443154 1.18680673169693e-06 NA NA NA hsa-miR-454-3p PIK3R3 0.668749059573955 2.42670710515113e-06 0.635454203069077 2.81455381573105e-08 mirMAP -0.155284428603942 8.0835303918136e-05 NA NA NA hsa-miR-590-5p PIK3R3 -0.103355559980404 0.310027295317092 0.635454203069077 2.81455381573105e-08 miRanda -0.243402254613955 1.30668545381547e-05 NA NA NA hsa-miR-624-5p PIK3R3 -0.639533773668123 6.79146620944254e-06 0.635454203069077 2.81455381573105e-08 MirTarget -0.124942360560089 0.00156005977445166 NA NA NA hsa-miR-92a-3p PIK3R3 0.212391012518195 0.134292268089997 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.21036606255577 1.06004328001549e-07 NA NA NA hsa-miR-107 PIK3R5 0.241662461253461 0.0170788899505389 -0.89989526759384 1.62789758196776e-07 miRanda -0.349504238477674 3.20976138937126e-05 NA NA NA hsa-miR-183-5p PIM1 2.33444328833177 1.52188109365421e-10 -1.03965437594354 8.81787316745957e-11 miRNATAP -0.140999567681768 1.54352845088907e-11 NA NA NA hsa-miR-331-3p PIM1 -0.283974346994635 0.0373785411053202 -1.03965437594354 8.81787316745957e-11 miRNATAP -0.172101062614807 0.00338759865851184 NA NA NA hsa-miR-769-3p PIM1 0.618139013155289 0.000147293288426878 -1.03965437594354 8.81787316745957e-11 PITA -0.195701116978272 8.60325705064665e-05 NA NA NA hsa-let-7e-5p PRLR 0.0350298755544731 0.811068614727804 -0.35423198863653 0.0761158267261502 miRNATAP -0.273328229298226 3.82477856037307e-05 NA NA NA hsa-let-7i-5p PRLR -0.14267936165213 0.154141689875847 -0.35423198863653 0.0761158267261502 miRNATAP -0.433060428623212 9.11939198432789e-06 NA NA NA hsa-miR-143-5p PRLR -0.42696209881145 0.00646356677356831 -0.35423198863653 0.0761158267261502 mirMAP -0.250004589770104 5.13344426170688e-05 NA NA NA hsa-miR-181c-5p PRLR -0.00639394152050299 0.969127212255928 -0.35423198863653 0.0761158267261502 miRNATAP -0.356818883265105 8.04944459289478e-10 NA NA NA hsa-miR-218-5p PRLR -0.500091158894849 0.0398595700240766 -0.35423198863653 0.0761158267261502 miRNATAP -0.192599605107286 1.11838403979325e-06 NA NA NA hsa-miR-22-5p PRLR -0.630365901263172 3.32415348030414e-05 -0.35423198863653 0.0761158267261502 mirMAP -0.371336595273348 3.12675979858811e-09 NA NA NA hsa-miR-30a-3p PRLR -1.52720594401486 1.3830066075708e-17 -0.35423198863653 0.0761158267261502 mirMAP -0.146405189240048 0.00508502911838107 NA NA NA hsa-miR-30a-5p PRLR -0.626257932887855 0.000108198196973765 -0.35423198863653 0.0761158267261502 miRNATAP -0.188173220453369 0.00164448573282991 NA NA NA hsa-miR-330-3p PRLR -0.332364259424489 0.0316051913061459 -0.35423198863653 0.0761158267261502 mirMAP;miRNATAP -0.227712677594328 0.000397116147011915 NA NA NA hsa-miR-181a-5p PTPN11 0.250113435902954 0.0551933249319293 -0.324998377632372 0.000647318034968802 miRNAWalker2_validate;miRTarBase -0.10436975560246 0.00355721073615052 NA NA NA hsa-miR-30d-3p PTPN11 -0.120562286038759 0.329549534782125 -0.324998377632372 0.000647318034968802 mirMAP -0.131571111343423 0.00049799614341566 NA NA NA hsa-miR-660-5p PTPN11 0.989755850734071 5.69930767464937e-14 -0.324998377632372 0.000647318034968802 mirMAP -0.110622431233159 0.00126771284106605 NA NA NA hsa-miR-122-5p SOCS1 -1.23907441373955 4.42181244888642e-06 -0.39709090094722 0.0775490855454473 miRNAWalker2_validate -0.138451063557538 0.000543541554177701 NA NA NA hsa-miR-107 SOCS2 0.241662461253461 0.0170788899505389 -2.6066749255576 8.74860477027169e-27 miRanda -0.369302337019759 0.00336572624043003 NA NA NA hsa-miR-16-1-3p SOCS2 0.392360028038559 0.00112481918108198 -2.6066749255576 8.74860477027169e-27 mirMAP -0.414229777525432 7.69553182613732e-05 NA NA NA hsa-miR-186-5p SOCS2 -0.060103391373687 0.535288717081205 -2.6066749255576 8.74860477027169e-27 mirMAP -0.563906847706915 1.78916860066776e-05 NA NA NA hsa-miR-19a-3p SOCS2 1.01712596153672 2.57753201450625e-07 -2.6066749255576 8.74860477027169e-27 mirMAP -0.311278593662378 6.63083243177328e-07 NA NA NA hsa-miR-19b-3p SOCS2 0.601279551368824 0.00016685097085251 -2.6066749255576 8.74860477027169e-27 mirMAP -0.316467742568874 5.53737631720871e-05 NA NA NA hsa-miR-25-3p SOCS2 0.633062563556379 3.68686354834328e-10 -2.6066749255576 8.74860477027169e-27 mirMAP -0.839548706915915 3.85007359302001e-12 NA NA NA hsa-miR-320a SOCS2 0.325285936317332 0.0221415065838824 -2.6066749255576 8.74860477027169e-27 miRanda -0.233215013125564 0.00899858056833914 NA NA NA hsa-miR-324-5p SOCS2 0.372933276649782 0.00592280066108904 -2.6066749255576 8.74860477027169e-27 miRanda -0.713984537467652 3.23503051812282e-15 NA NA NA hsa-miR-362-5p SOCS2 0.717921690799312 1.68392734504524e-05 -2.6066749255576 8.74860477027169e-27 TargetScan -0.30618501713941 4.35186408807719e-05 NA NA NA hsa-miR-421 SOCS2 0.941856334694081 6.12167297054077e-08 -2.6066749255576 8.74860477027169e-27 miRanda -0.596852063842572 6.78555195114344e-18 NA NA NA hsa-miR-500a-3p SOCS2 1.18913245435489 1.59516890341346e-16 -2.6066749255576 8.74860477027169e-27 miRNATAP -0.652001826878148 1.91232168200575e-15 NA NA NA hsa-miR-501-5p SOCS2 1.15231083477882 2.98906150004088e-10 -2.6066749255576 8.74860477027169e-27 mirMAP -0.508092289243771 1.15210070950362e-14 NA NA NA hsa-miR-940 SOCS2 0.453020092551484 0.0177054921651997 -2.6066749255576 8.74860477027169e-27 miRNATAP -0.418135074229736 4.15542848925871e-10 NA NA NA hsa-miR-455-5p SOCS3 -0.270546034117157 0.0581320703577731 -2.30554269388213 1.3157298468501e-20 miRanda -0.360992723185637 4.63952771606627e-05 NA NA NA hsa-miR-508-3p SOCS3 1.48874058858819 8.16277343202446e-07 -2.30554269388213 1.3157298468501e-20 PITA -0.164840396075397 9.74198062289116e-05 NA NA NA hsa-miR-107 SOCS4 0.241662461253461 0.0170788899505389 -0.00799562822546118 0.920721716920263 miRanda -0.121070091747575 0.00173902179345517 NA NA NA hsa-miR-455-5p SOCS4 -0.270546034117157 0.0581320703577731 -0.00799562822546118 0.920721716920263 miRanda -0.111227426429981 4.24940276023263e-05 NA NA NA hsa-miR-139-5p SOCS7 -2.11299531796557 8.16407076415038e-28 1.23630045260618 2.28814323600538e-14 miRNATAP -0.297562060350442 6.68201659971497e-15 NA NA NA hsa-miR-145-5p SOCS7 -1.4795885711477 6.47308361543414e-16 1.23630045260618 2.28814323600538e-14 miRNAWalker2_validate -0.201080343209046 2.31433808114246e-06 23392170 socs7 a target gene of microRNA 145 regulates interferon β induction through STAT3 nuclear translocation in bladder cancer cells; Then we focused on the suppressor of cytokine signaling 7 socs7 whose expression level was upregulated in bladder cancer cells compared with its level in normal human urothelial cells as a putative target gene involved in IFN-β induction by miR-145; Expectedly exogenous miR-145 decreased the expression level of SOCS7 and socs7-silencing enhanced IFN-β induction by transfection with a TLR3 ligand polyinosinic acid-polycytidylic acid PIC; The results of a luciferase reporter assay revealed that miR-145 targeted socs7; In conclusion the machinery of IFN-β induction through the regulation of SOCS7 by miR-145 was closely associated with the induction of apoptosis; Moreover exogenous miR-145 promoted IFN-β induction by targeting socs7 which resulted in the nuclear translocation of STAT3 bladder cancer hsa-miR-455-3p SOCS7 -1.3998033821095 5.72010709806871e-17 1.23630045260618 2.28814323600538e-14 miRNATAP -0.241140869300095 2.01109582124001e-07 NA NA NA hsa-miR-16-1-3p SOS1 0.392360028038559 0.00112481918108198 0.05751534180893 0.493041822065916 mirMAP -0.102425524653968 0.00242014805702593 NA NA NA hsa-miR-17-5p SOS1 0.698861147045461 2.43854106455398e-05 0.05751534180893 0.493041822065916 MirTarget;TargetScan;miRNATAP -0.11660606180243 1.37071072811905e-06 NA NA NA hsa-miR-193a-3p SOS1 -0.117675551589896 0.309391958208578 0.05751534180893 0.493041822065916 miRanda -0.167375491584816 1.83548073403882e-06 NA NA NA hsa-miR-20a-5p SOS1 0.854326758727003 5.04256669663285e-07 0.05751534180893 0.493041822065916 MirTarget;miRNATAP -0.100063123806167 2.02695724421345e-05 NA NA NA hsa-miR-27a-3p SOS1 -0.370807380415112 0.00875721956202713 0.05751534180893 0.493041822065916 MirTarget;miRNATAP -0.120226883007702 2.62552416504337e-05 NA NA NA hsa-miR-30b-5p SOS1 -0.54056186708617 2.44688760798341e-05 0.05751534180893 0.493041822065916 mirMAP -0.125950231468023 6.21375879766061e-05 NA NA NA hsa-miR-339-5p SOS1 0.280589919878422 0.0355660282647215 0.05751534180893 0.493041822065916 miRNATAP -0.15315814967207 4.05818038840081e-07 NA NA NA hsa-miR-590-5p SOS1 -0.103355559980404 0.310027295317092 0.05751534180893 0.493041822065916 miRanda -0.115356122634493 0.00426551999929742 NA NA NA hsa-miR-146b-5p SOS2 0.419719546795449 0.0457375823220155 -0.326258424146275 0.000900714126323724 miRanda -0.110125845201631 1.10330856080798e-06 NA NA NA hsa-miR-21-5p SOS2 1.51084295924322 1.54551622173259e-34 -0.326258424146275 0.000900714126323724 miRNATAP -0.279899776012046 7.56477883436428e-16 NA NA NA hsa-miR-590-5p SOS2 -0.103355559980404 0.310027295317092 -0.326258424146275 0.000900714126323724 PITA;miRanda;miRNATAP -0.144457452099512 0.00241614674200376 NA NA NA hsa-miR-103a-3p SPRED1 0.765568928457606 3.05497476509383e-12 -0.584055575592488 6.88990777515141e-05 miRNAWalker2_validate -0.181118341434554 0.00488093270473706 NA NA NA hsa-miR-107 SPRED1 0.241662461253461 0.0170788899505389 -0.584055575592488 6.88990777515141e-05 miRanda -0.51880657241032 9.59965499094253e-14 NA NA NA hsa-miR-15a-5p SPRED1 0.349521211668244 0.000770735998804736 -0.584055575592488 6.88990777515141e-05 miRNATAP -0.189523601555987 0.00647253346256402 NA NA NA hsa-miR-16-1-3p SPRED1 0.392360028038559 0.00112481918108198 -0.584055575592488 6.88990777515141e-05 mirMAP -0.22061891343206 0.000217341213828164 NA NA NA hsa-miR-194-5p SPRED1 -0.292530160992458 0.0996141384876663 -0.584055575592488 6.88990777515141e-05 miRNATAP -0.3930772309152 1.1090686314509e-24 NA NA NA hsa-miR-204-5p SPRED1 -0.537962150012103 0.0330895493358849 -0.584055575592488 6.88990777515141e-05 miRNATAP -0.116354907893019 4.04686832250361e-05 NA NA NA hsa-miR-20a-5p SPRED1 0.854326758727003 5.04256669663285e-07 -0.584055575592488 6.88990777515141e-05 miRNATAP -0.165176765151827 7.31830031380624e-05 NA NA NA hsa-miR-32-3p SPRED1 0.219109440121582 0.207217051619543 -0.584055575592488 6.88990777515141e-05 mirMAP -0.138450993648101 0.00122723674606877 NA NA NA hsa-miR-32-5p SPRED1 0.0806126674664016 0.548984992497432 -0.584055575592488 6.88990777515141e-05 mirMAP -0.254860907847696 1.78721520859204e-06 NA NA NA hsa-miR-34a-5p SPRED1 1.03694231790865 5.74864019540594e-14 -0.584055575592488 6.88990777515141e-05 miRNATAP -0.271515837377171 5.93841154487705e-08 NA NA NA hsa-miR-664a-3p SPRED1 0.485807855553031 0.000732553249798598 -0.584055575592488 6.88990777515141e-05 mirMAP -0.146148556366959 0.00343010970698501 NA NA NA hsa-miR-93-5p SPRED1 1.39518349670953 2.84167728726712e-25 -0.584055575592488 6.88990777515141e-05 miRNAWalker2_validate;miRNATAP -0.144988058414358 0.00416490972787043 NA NA NA hsa-miR-339-5p SPRED2 0.280589919878422 0.0355660282647215 -0.64627482422713 9.83910755930565e-09 miRanda -0.161700631610031 0.000108287391388511 NA NA NA hsa-miR-532-5p SPRED2 1.02729546510601 9.93318913966636e-16 -0.64627482422713 9.83910755930565e-09 PITA -0.116934052049478 0.00565658258358561 NA NA NA hsa-miR-93-5p SPRED2 1.39518349670953 2.84167728726712e-25 -0.64627482422713 9.83910755930565e-09 mirMAP -0.119244528629453 0.00234532627493869 NA NA NA hsa-miR-107 SPRY1 0.241662461253461 0.0170788899505389 -0.191200095311501 0.161703034220406 miRanda;miRNATAP -0.211884200993692 0.00133992671665214 NA NA NA hsa-miR-20a-3p SPRY1 -0.318177901603857 0.0467885456739855 -0.191200095311501 0.161703034220406 miRNATAP -0.143943722299696 0.000531053170131261 NA NA NA hsa-miR-21-5p SPRY1 1.51084295924322 1.54551622173259e-34 -0.191200095311501 0.161703034220406 miRNATAP -0.14613864441268 0.00329886441657982 24155920 Functional studies showed that miR-21 over-expression in GICs induced comparable cell differentiation features and targeted SPRY1 mRNA which encodes for a negative regulator of neural stem-cell differentiation differentiation glioblastoma hsa-miR-324-3p SPRY1 0.260348469146494 0.0506141704203545 -0.191200095311501 0.161703034220406 miRNAWalker2_validate -0.174277401590715 0.000487592224101676 NA NA NA hsa-miR-339-5p SPRY1 0.280589919878422 0.0355660282647215 -0.191200095311501 0.161703034220406 miRanda -0.224492615840156 5.9843085206186e-06 NA NA NA hsa-miR-3615 SPRY1 0.437674495807452 0.000852818785910106 -0.191200095311501 0.161703034220406 miRNAWalker2_validate -0.179220317045099 0.000386097333406609 NA NA NA hsa-miR-421 SPRY1 0.941856334694081 6.12167297054077e-08 -0.191200095311501 0.161703034220406 PITA;miRanda;miRNATAP -0.126455909377758 0.000806108501310763 NA NA NA hsa-miR-550a-3p SPRY1 0.0421988124005088 0.798971000685886 -0.191200095311501 0.161703034220406 miRNATAP -0.143768245696203 0.000438171002042525 NA NA NA hsa-miR-590-5p SPRY1 -0.103355559980404 0.310027295317092 -0.191200095311501 0.161703034220406 PITA;miRanda;miRNATAP -0.288589276024326 1.07623694506845e-05 NA NA NA hsa-miR-21-5p SPRY2 1.51084295924322 1.54551622173259e-34 -1.61009043608154 1.29635420799403e-31 miRNAWalker2_validate;miRTarBase;miRNATAP -0.425735867826972 4.40806254549318e-16 22322462 Inhibition of microRNA-21 mir‑21 induced upregulation of Spry2 and PTEN which underscores the importance of mir-21 in Spry2-associated tumorigenesis of the colon tumorigenesis colon cancer hsa-miR-330-5p SPRY2 0.442231058604099 0.0053308560843808 -1.61009043608154 1.29635420799403e-31 miRanda;miRNATAP -0.127832023516751 0.005059629917728 NA NA NA hsa-miR-452-5p SPRY2 1.91544498799508 1.81995982853313e-14 -1.61009043608154 1.29635420799403e-31 miRNATAP -0.125727598169037 6.10369015311573e-06 NA NA NA hsa-miR-338-5p SPRY3 -0.221898432884726 0.252390988727086 0.103316845481917 0.39401138866056 mirMAP -0.122665621330694 5.54791126287423e-05 NA NA NA hsa-miR-589-3p SPRY3 1.16846704028095 5.88525574424201e-11 0.103316845481917 0.39401138866056 mirMAP -0.110160820999389 0.000814331293301994 NA NA NA hsa-miR-148a-5p SPRY4 -0.767626696027761 1.08359477494797e-06 -0.334402157998528 0.0123258475801913 mirMAP -0.267843808321516 2.35629523962814e-11 NA NA NA hsa-miR-192-5p SPRY4 -0.50188499512787 0.00344713341196035 -0.334402157998528 0.0123258475801913 miRNAWalker2_validate -0.12594333673096 0.000869467405159125 NA NA NA hsa-miR-548b-3p SPRY4 -0.0203576084717134 0.930819503166956 -0.334402157998528 0.0123258475801913 miRNATAP -0.157096842375415 1.58916483449717e-08 NA NA NA hsa-miR-92a-3p STAM2 0.212391012518195 0.134292268089997 -0.12344203260833 0.0862043152394216 mirMAP -0.10568222011291 1.60551776998704e-05 NA NA NA hsa-miR-30c-1-3p STAT1 -1.39373825444537 6.39912952911454e-17 0.0211728282562005 0.88997583338294 MirTarget -0.120077040850245 0.005855735380131 NA NA NA hsa-miR-30c-2-3p STAT1 -1.39811819128587 3.66376924527665e-15 0.0211728282562005 0.88997583338294 MirTarget -0.131243958250956 0.00116055787753827 NA NA NA hsa-miR-361-5p STAT1 0.233202959858696 0.00961572812255327 0.0211728282562005 0.88997583338294 miRanda -0.289486118414617 0.000515140007029611 NA NA NA hsa-miR-455-5p STAT1 -0.270546034117157 0.0581320703577731 0.0211728282562005 0.88997583338294 miRanda -0.147591756706305 0.0047396940322775 NA NA NA hsa-let-7e-5p STAT2 0.0350298755544731 0.811068614727804 -0.0631967524278743 0.496493089657879 MirTarget -0.199258104879113 4.51866995601304e-11 NA NA NA hsa-miR-125a-3p STAT2 -0.841683158494395 3.51202687176603e-05 -0.0631967524278743 0.496493089657879 miRanda -0.131491484863299 2.75434643211815e-09 NA NA NA hsa-miR-125a-5p STAT2 -0.91219969372382 1.38256246489548e-07 -0.0631967524278743 0.496493089657879 miRNAWalker2_validate -0.159855593535649 2.18315912490384e-10 NA NA NA hsa-miR-24-3p STAT2 -0.257825594021966 0.00689742600215061 -0.0631967524278743 0.496493089657879 MirTarget -0.240399180015519 3.42029607215584e-07 NA NA NA hsa-miR-106b-5p STAT3 0.648901865047099 8.24870862047885e-09 -0.787818268277734 2.21497977966771e-15 miRNATAP -0.401207033583012 8.89639067696154e-22 27325313 We also found that EMMPRIN could down-regulate miR-106a and miR-106b expression in breast cancer cells which led to activating STAT3 and enhancing HIF-1α expression breast cancer hsa-miR-17-5p STAT3 0.698861147045461 2.43854106455398e-05 -0.787818268277734 2.21497977966771e-15 TargetScan;miRNATAP -0.204114886148471 3.13517806702149e-12 NA NA NA hsa-miR-20a-5p STAT3 0.854326758727003 5.04256669663285e-07 -0.787818268277734 2.21497977966771e-15 miRNAWalker2_validate;miRNATAP -0.204002628417709 5.95071178568667e-13 NA NA NA hsa-miR-320a STAT3 0.325285936317332 0.0221415065838824 -0.787818268277734 2.21497977966771e-15 miRanda -0.147916976276494 2.44468794235007e-05 NA NA NA hsa-miR-590-5p STAT3 -0.103355559980404 0.310027295317092 -0.787818268277734 2.21497977966771e-15 miRanda;miRNATAP -0.163260246912667 0.000997206809266545 27757042 We found that the AKT/ERK and STAT3 signaling pathways were activated by miR-590-5p overexpression gastric cancer hsa-miR-92a-3p STAT3 0.212391012518195 0.134292268089997 -0.787818268277734 2.21497977966771e-15 miRNAWalker2_validate -0.185338500709944 1.17334794419737e-07 23820254 STAT3 upregulates miR 92a to inhibit RECK expression and to promote invasiveness of lung cancer cells; We demonstrate that STAT3 upregulates miR-92a to repress RECK via post-transcriptional inhibition lung cancer hsa-miR-93-5p STAT3 1.39518349670953 2.84167728726712e-25 -0.787818268277734 2.21497977966771e-15 miRNAWalker2_validate;miRNATAP -0.332682802836239 1.77183024731607e-23 NA NA NA hsa-miR-21-3p STAT5B -0.484219378716006 0.00299941098417659 -0.206850819374259 0.00628123935115017 MirTarget -0.123627670641263 2.54618000627074e-08 NA NA NA hsa-miR-23a-3p STAT5B -0.178875974460574 0.135978273540604 -0.206850819374259 0.00628123935115017 MirTarget;miRNATAP -0.175327959060726 8.02448831645098e-09 NA NA NA hsa-miR-324-3p STAT5B 0.260348469146494 0.0506141704203545 -0.206850819374259 0.00628123935115017 miRNAWalker2_validate -0.104429177830288 0.000155808491592484 NA NA NA hsa-miR-342-3p STAT5B -0.319677314984262 0.0449813878317147 -0.206850819374259 0.00628123935115017 MirTarget;miRanda -0.124894762721916 4.27509470687132e-08 NA NA NA hsa-miR-877-5p STAT5B 1.35669625926821 1.43008125755656e-11 -0.206850819374259 0.00628123935115017 MirTarget -0.107174522097755 5.68369496165315e-09 NA NA NA hsa-miR-93-3p STAT5B 0.402821129107592 0.00131324842735588 -0.206850819374259 0.00628123935115017 miRNAWalker2_validate -0.108667710764145 0.000204211018959862 NA NA NA hsa-miR-361-5p STAT6 0.233202959858696 0.00961572812255327 -0.176153436470365 0.108477458631757 miRanda -0.169538590993668 0.00466238758743129 NA NA NA hsa-miR-590-5p STAT6 -0.103355559980404 0.310027295317092 -0.176153436470365 0.108477458631757 miRanda -0.16508805068743 0.00181565872472259 NA NA NA hsa-miR-338-3p TSLP 0.543135607704581 0.00461167747143826 -3.74355772687801 4.4384857762346e-23 miRanda -0.381073753034657 0.000163332140224339 NA NA NA