miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-5p AARSD1 -0.959013717270803 5.95127281258643e-11 0.388114466943729 0.000197391487282295 miRNAWalker2_validate -0.220798544343843 3.7350545601553e-11 NA NA NA hsa-let-7b-5p AATF -0.959013717270803 5.95127281258643e-11 0.61970431841542 9.99130236790938e-15 miRNAWalker2_validate -0.246383002524444 5.05065827912433e-22 NA NA NA hsa-let-7a-5p ABCB9 -0.328069937201898 0.000464344093744051 1.00955603859492 1.63896842371547e-09 MirTarget;TargetScan -0.199329203903109 0.025970274838597 NA NA NA hsa-let-7c-5p ABCB9 -1.70744661345097 2.87934212005942e-20 1.00955603859492 1.63896842371547e-09 MirTarget -0.273859383833607 6.80741103254938e-11 NA NA NA hsa-let-7c-5p ABCC10 -1.70744661345097 2.87934212005942e-20 1.42399346571582 1.7634577339245e-36 MirTarget -0.301575187605271 5.72062761788124e-25 NA NA NA hsa-let-7a-5p ABCC5 -0.328069937201898 0.000464344093744051 1.23282495059029 1.29865153692267e-30 TargetScan;miRNATAP -0.274661902019713 4.54339179387744e-06 NA NA NA hsa-let-7b-5p ABCC5 -0.959013717270803 5.95127281258643e-11 1.23282495059029 1.29865153692267e-30 miRNATAP -0.202987801143339 4.39282120683187e-08 NA NA NA hsa-let-7b-5p ABCF1 -0.959013717270803 5.95127281258643e-11 0.320046322742304 1.33991042529606e-05 miRNAWalker2_validate -0.122788686116537 2.38478093311255e-07 NA NA NA hsa-let-7d-5p ABHD14B 0.0503292020123807 0.702580311853671 -0.880768013030226 2.55573885989991e-11 MirTarget -0.156132232332006 0.00188407630833816 NA NA NA hsa-let-7b-5p ACACA -0.959013717270803 5.95127281258643e-11 0.777902042094557 1.56408455357082e-10 miRNAWalker2_validate -0.249908503482641 3.02374378326778e-10 NA NA NA hsa-let-7a-5p ACAP3 -0.328069937201898 0.000464344093744051 0.470112715013507 8.1973608159084e-06 TargetScan -0.122884679703537 0.0273875229690073 NA NA NA hsa-let-7d-5p ACVR1C 0.0503292020123807 0.702580311853671 -2.19871896765337 7.84657232630462e-19 MirTarget;miRNATAP -0.467124977184397 1.03044182442353e-06 NA NA NA hsa-let-7d-5p ADRB2 0.0503292020123807 0.702580311853671 -1.6290643565295 8.9517122650496e-10 MirTarget -0.527173218013715 1.27783640143678e-07 NA NA NA hsa-let-7b-5p ADRM1 -0.959013717270803 5.95127281258643e-11 0.193074518196434 0.019515691863073 miRNAWalker2_validate -0.158440490972688 1.95803608479009e-09 NA NA NA hsa-let-7a-5p ADSL -0.328069937201898 0.000464344093744051 0.461595049175949 9.38245131473071e-08 miRNAWalker2_validate -0.173359155903942 0.000143512443430028 NA NA NA hsa-let-7a-5p AEN -0.328069937201898 0.000464344093744051 0.282625024454205 0.0123880607527212 MirTarget;TargetScan -0.166122203450168 0.00498299775365761 NA NA NA hsa-let-7b-5p AEN -0.959013717270803 5.95127281258643e-11 0.282625024454205 0.0123880607527212 MirTarget -0.15666823424104 1.84741457917948e-05 NA NA NA hsa-let-7d-5p AEN 0.0503292020123807 0.702580311853671 0.282625024454205 0.0123880607527212 MirTarget -0.131478794657396 0.00174229636429569 NA NA NA hsa-let-7b-5p AFF2 -0.959013717270803 5.95127281258643e-11 1.39588537883969 0.000457287577801629 MirTarget -0.388186693248782 0.00293007373125891 NA NA NA hsa-let-7d-5p AFF2 0.0503292020123807 0.702580311853671 1.39588537883969 0.000457287577801629 MirTarget -0.332956012946613 0.0258058704186231 NA NA NA hsa-let-7b-5p AGFG2 -0.959013717270803 5.95127281258643e-11 -0.0193527168337146 0.870605356857287 miRNAWalker2_validate -0.16969855225402 9.37848243409559e-06 NA NA NA hsa-let-7a-5p AIDA -0.328069937201898 0.000464344093744051 0.391907662880329 2.71263058504648e-06 miRNAWalker2_validate -0.11340873062366 0.0100717965645682 NA NA NA hsa-let-7a-5p AIFM1 -0.328069937201898 0.000464344093744051 -0.385341500009001 0.000487220407124204 TargetScan;miRNATAP -0.156878186610717 0.00688659078633595 NA NA NA hsa-let-7d-5p AIFM1 0.0503292020123807 0.702580311853671 -0.385341500009001 0.000487220407124204 miRNATAP -0.227865460454543 2.10775715366441e-08 NA NA NA hsa-let-7d-5p AKAP6 0.0503292020123807 0.702580311853671 -0.968677768825482 1.23169099553274e-07 MirTarget -0.298493340074135 1.3916765951421e-05 NA NA NA hsa-let-7b-5p ALG3 -0.959013717270803 5.95127281258643e-11 0.596433475534509 5.75279857087551e-11 miRNAWalker2_validate -0.229665046870711 4.82453884244485e-15 NA NA NA hsa-let-7b-5p AMT -0.959013717270803 5.95127281258643e-11 -0.849284315228912 5.98433042510704e-07 MirTarget -0.15917778214134 0.00456722079707591 NA NA NA hsa-let-7d-5p AMT 0.0503292020123807 0.702580311853671 -0.849284315228912 5.98433042510704e-07 MirTarget -0.298732103315052 2.60563325499804e-06 NA NA NA hsa-let-7c-5p ANKRD49 -1.70744661345097 2.87934212005942e-20 0.399680304237402 6.46826622613075e-08 MirTarget -0.100989362644086 4.78554482063786e-08 NA NA NA hsa-let-7a-5p ANKRD52 -0.328069937201898 0.000464344093744051 1.45719998646575 1.747377108051e-36 TargetScan;mirMAP;miRNATAP -0.182551056377154 0.00574817280515972 NA NA NA hsa-let-7b-5p ANKRD52 -0.959013717270803 5.95127281258643e-11 1.45719998646575 1.747377108051e-36 miRNAWalker2_validate;mirMAP;miRNATAP -0.209621282261084 2.54538682865439e-07 NA NA NA hsa-let-7b-5p ANKZF1 -0.959013717270803 5.95127281258643e-11 0.847749468566496 1.02258150197508e-21 miRNAWalker2_validate -0.248494821039684 1.49771297944813e-17 NA NA NA hsa-let-7a-5p AP1S1 -0.328069937201898 0.000464344093744051 0.547848699917453 6.71692521784566e-09 MirTarget;TargetScan;miRNATAP -0.225362613838828 6.13482664221612e-06 NA NA NA hsa-let-7b-5p AP1S1 -0.959013717270803 5.95127281258643e-11 0.547848699917453 6.71692521784566e-09 MirTarget;miRNATAP -0.165133227272232 8.77473614296785e-08 NA NA NA hsa-let-7d-5p AP1S1 0.0503292020123807 0.702580311853671 0.547848699917453 6.71692521784566e-09 MirTarget;miRNATAP -0.170022543202699 1.52563411404732e-06 NA NA NA hsa-let-7a-5p APC2 -0.328069937201898 0.000464344093744051 1.72078641102954 8.65364092042936e-19 TargetScan -0.296144411661104 0.00537712418099154 NA NA NA hsa-let-7b-5p APRT -0.959013717270803 5.95127281258643e-11 0.187591508837564 0.126627076858093 miRNAWalker2_validate -0.271254577486278 3.42106820074369e-12 NA NA NA hsa-let-7b-5p ARFIP2 -0.959013717270803 5.95127281258643e-11 0.369397226468017 2.03018749407951e-06 miRNAWalker2_validate -0.158620673271412 2.26602036365655e-10 NA NA NA hsa-let-7b-5p ARG2 -0.959013717270803 5.95127281258643e-11 0.152563039951481 0.435912153571847 MirTarget -0.176385823301525 0.0056247597076055 NA NA NA hsa-let-7d-5p ARG2 0.0503292020123807 0.702580311853671 0.152563039951481 0.435912153571847 MirTarget -0.242075088896384 0.000855230857675554 NA NA NA hsa-let-7d-5p ARHGAP28 0.0503292020123807 0.702580311853671 0.592716397637913 0.0330797805481668 MirTarget;miRNATAP -0.214701440354088 0.0386713791908994 NA NA NA hsa-let-7a-5p ARID3A -0.328069937201898 0.000464344093744051 1.53198637867813 1.48041716318634e-09 TargetScan -0.634314723159741 2.27837440570244e-06 NA NA NA hsa-let-7b-5p ARID3A -0.959013717270803 5.95127281258643e-11 1.53198637867813 1.48041716318634e-09 miRNAWalker2_validate -0.379381852043462 5.66029020296306e-06 NA NA NA hsa-let-7a-5p ARID3B -0.328069937201898 0.000464344093744051 0.456196233773583 0.000205068052872381 miRNAWalker2_validate;TargetScan;miRNATAP -0.165352041176341 0.0105903244093148 NA NA NA hsa-let-7b-5p ARID3B -0.959013717270803 5.95127281258643e-11 0.456196233773583 0.000205068052872381 miRNAWalker2_validate;miRNATAP -0.13536640135835 0.000745325821616847 NA NA NA hsa-let-7b-5p ASNA1 -0.959013717270803 5.95127281258643e-11 0.581579212663772 5.45618031422578e-12 miRNAWalker2_validate -0.193415670090801 1.71619548939854e-12 NA NA NA hsa-let-7b-5p ASPSCR1 -0.959013717270803 5.95127281258643e-11 0.72325226189431 1.25309543560554e-05 miRNAWalker2_validate -0.428704522940623 3.53423909565633e-16 NA NA NA hsa-let-7b-5p ATAD3B -0.959013717270803 5.95127281258643e-11 0.759817630998731 6.46114858749152e-08 miRNAWalker2_validate -0.290377841647772 1.86418452291109e-10 NA NA NA hsa-let-7a-5p ATG10 -0.328069937201898 0.000464344093744051 0.346641307647138 0.000519861295938401 MirTarget -0.210289953286486 5.549926369071e-05 NA NA NA hsa-let-7b-5p ATG10 -0.959013717270803 5.95127281258643e-11 0.346641307647138 0.000519861295938401 MirTarget -0.19557271438585 1.05867867038041e-09 NA NA NA hsa-let-7d-5p ATG10 0.0503292020123807 0.702580311853671 0.346641307647138 0.000519861295938401 MirTarget -0.162554557495955 1.11928444753801e-05 NA NA NA hsa-let-7a-5p ATG4B -0.328069937201898 0.000464344093744051 0.374330137124094 1.98406073548852e-06 TargetScan -0.172024177764226 3.04483664183942e-05 NA NA NA hsa-let-7b-5p ATG4B -0.959013717270803 5.95127281258643e-11 0.374330137124094 1.98406073548852e-06 miRNAWalker2_validate;miRNATAP -0.119045444802331 3.331150892866e-06 NA NA NA hsa-let-7b-5p ATOX1 -0.959013717270803 5.95127281258643e-11 0.43108708114564 0.00495610810534198 miRNAWalker2_validate -0.250673313556527 4.24857385551006e-07 NA NA NA hsa-let-7b-5p ATP6V0A1 -0.959013717270803 5.95127281258643e-11 0.284956083440675 0.00395460771311008 miRNAWalker2_validate -0.115519870992339 0.000323036760961507 NA NA NA hsa-let-7a-5p ATP6V1C1 -0.328069937201898 0.000464344093744051 0.875287163526939 8.28405374117091e-15 TargetScan -0.27515235731782 5.36919852695575e-06 NA NA NA hsa-let-7b-5p ATP6V1F -0.959013717270803 5.95127281258643e-11 0.671242590424392 4.12098975416581e-12 miRNAWalker2_validate -0.196120576974563 6.29993063388874e-10 NA NA NA hsa-let-7b-5p ATXN2L -0.959013717270803 5.95127281258643e-11 0.611974248116638 1.12366931914732e-16 miRNAWalker2_validate -0.102678429765359 3.2695230093416e-05 NA NA NA hsa-let-7a-5p ATXN7L2 -0.328069937201898 0.000464344093744051 1.06992494046032 6.78987290211496e-20 miRNATAP -0.183270654707166 0.00430457142949504 NA NA NA hsa-let-7b-5p ATXN7L2 -0.959013717270803 5.95127281258643e-11 1.06992494046032 6.78987290211496e-20 miRNATAP -0.187889237137218 2.09501980409452e-06 NA NA NA hsa-let-7b-5p ATXN7L3 -0.959013717270803 5.95127281258643e-11 0.698895357070855 3.23244219063052e-16 miRNATAP -0.100467580631945 0.000478478706236909 NA NA NA hsa-let-7b-5p AUP1 -0.959013717270803 5.95127281258643e-11 0.149888939431994 0.0557902258274827 miRNAWalker2_validate -0.173068209088289 2.97173601008266e-12 NA NA NA hsa-let-7b-5p AURKA -0.959013717270803 5.95127281258643e-11 2.7082284126342 1.65469935302537e-44 miRNAWalker2_validate -0.43833647332621 2.21232684569915e-10 NA NA NA hsa-let-7b-5p AURKB -0.959013717270803 5.95127281258643e-11 3.49342722879335 6.3137526890155e-40 miRNAWalker2_validate -0.59892219770987 1.29892409015906e-10 NA NA NA hsa-let-7a-5p B3GAT3 -0.328069937201898 0.000464344093744051 0.500147145181797 8.60443511152235e-06 TargetScan -0.376107643864305 9.79817331304878e-11 NA NA NA hsa-let-7b-5p BBS7 -0.959013717270803 5.95127281258643e-11 0.266690014901358 0.0901347389297157 miRNAWalker2_validate -0.103750319195696 0.043324090227809 NA NA NA hsa-let-7a-5p BCAT1 -0.328069937201898 0.000464344093744051 1.32893980115268 4.1690960256351e-12 miRNAWalker2_validate;TargetScan -0.284949244545425 0.00570837602527237 NA NA NA hsa-let-7b-5p BFSP1 -0.959013717270803 5.95127281258643e-11 1.35950359514717 5.25906110985343e-15 miRNAWalker2_validate -0.204338556146876 0.000471192970346928 NA NA NA hsa-let-7b-5p BGLAP -0.959013717270803 5.95127281258643e-11 0.569492332183998 0.00108690464303013 miRNAWalker2_validate -0.277183306724421 9.21759983800775e-07 NA NA NA hsa-let-7a-5p BIN3 -0.328069937201898 0.000464344093744051 -0.399535334416072 5.93315960237536e-05 TargetScan -0.119297122544702 0.0228963262226993 NA NA NA hsa-let-7b-5p BIRC5 -0.959013717270803 5.95127281258643e-11 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate -0.714894665750299 6.76492235439612e-11 NA NA NA hsa-let-7a-5p BRI3BP -0.328069937201898 0.000464344093744051 0.530956076865949 4.70235025945712e-06 mirMAP -0.186890392162163 0.00226324580625177 NA NA NA hsa-let-7b-5p BRI3BP -0.959013717270803 5.95127281258643e-11 0.530956076865949 4.70235025945712e-06 mirMAP -0.158014665041651 3.0642017162365e-05 NA NA NA hsa-let-7a-5p BZW2 -0.328069937201898 0.000464344093744051 0.577245550489843 7.10575922293368e-08 MirTarget;TargetScan;miRNATAP -0.21447061511169 0.000151401372593437 NA NA NA hsa-let-7b-5p BZW2 -0.959013717270803 5.95127281258643e-11 0.577245550489843 7.10575922293368e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.204569817825114 4.16018392161094e-09 NA NA NA hsa-let-7c-5p BZW2 -1.70744661345097 2.87934212005942e-20 0.577245550489843 7.10575922293368e-08 MirTarget -0.203335965765395 1.43522953010322e-14 NA NA NA hsa-let-7b-5p C15orf41 -0.959013717270803 5.95127281258643e-11 0.9045246528293 6.09961285471487e-15 miRNATAP -0.137032510727526 0.000428283964659086 NA NA NA hsa-let-7b-5p C22orf29 -0.959013717270803 5.95127281258643e-11 1.09019898263552 1.10984149710713e-27 mirMAP -0.103729873798741 0.00283038951688884 NA NA NA hsa-let-7a-5p CACNA1E -0.328069937201898 0.000464344093744051 1.61336046300478 3.88892981462269e-05 TargetScan;miRNATAP -1.16201345216975 1.25526756388031e-08 NA NA NA hsa-let-7b-5p CACNA1E -0.959013717270803 5.95127281258643e-11 1.61336046300478 3.88892981462269e-05 miRNATAP -0.577794833541408 6.30098366622733e-06 NA NA NA hsa-let-7a-5p CACNB4 -0.328069937201898 0.000464344093744051 1.93077881386314 4.3815389499992e-11 TargetScan;miRNATAP -0.318150044224066 0.043406972002297 NA NA NA hsa-let-7b-5p CACNB4 -0.959013717270803 5.95127281258643e-11 1.93077881386314 4.3815389499992e-11 miRNATAP -0.431163587652539 8.99175330979893e-06 NA NA NA hsa-let-7d-5p CADM2 0.0503292020123807 0.702580311853671 -2.31674580160095 5.89007396472084e-10 MirTarget;miRNATAP -0.506427834265944 0.000354823378962793 NA NA NA hsa-let-7d-5p CALCOCO2 0.0503292020123807 0.702580311853671 -0.313335186322503 1.44086975938493e-05 miRNAWalker2_validate -0.116450506288025 1.37732429127143e-05 NA NA NA hsa-let-7a-5p CANT1 -0.328069937201898 0.000464344093744051 0.653872843340828 1.15958381427113e-16 TargetScan -0.14920679511214 0.000464089483417076 NA NA NA hsa-let-7a-5p CAP1 -0.328069937201898 0.000464344093744051 0.041054312688213 0.49168844951627 miRNATAP -0.100353871203335 0.00114533601930075 NA NA NA hsa-let-7b-5p CASKIN1 -0.959013717270803 5.95127281258643e-11 1.73450894991447 2.58018983860941e-08 miRNATAP -0.36732094492159 0.000359309545633918 NA NA NA hsa-let-7d-5p CBR4 0.0503292020123807 0.702580311853671 -1.37669382270307 4.66233042027365e-22 miRNAWalker2_validate -0.222245826972296 6.43643474496328e-05 NA NA NA hsa-let-7a-5p CBX2 -0.328069937201898 0.000464344093744051 2.25351244295968 1.73782786388514e-22 TargetScan;miRNATAP -0.309912771961128 0.0153237782693763 NA NA NA hsa-let-7b-5p CBX2 -0.959013717270803 5.95127281258643e-11 2.25351244295968 1.73782786388514e-22 miRNATAP -0.286085043662464 0.00030345826859684 NA NA NA hsa-let-7c-5p CBX5 -1.70744661345097 2.87934212005942e-20 0.352720475583158 0.00158496538783418 MirTarget -0.117320573000309 2.65277493570271e-05 NA NA NA hsa-let-7c-5p CBX6 -1.70744661345097 2.87934212005942e-20 -0.135925898836227 0.562356772831778 miRNAWalker2_validate -0.147751255324137 0.0120748662714877 NA NA NA hsa-let-7b-5p CCDC134 -0.959013717270803 5.95127281258643e-11 0.720368225334023 4.49465190590616e-09 miRNAWalker2_validate -0.13606167030148 0.000809925806922627 NA NA NA hsa-let-7b-5p CCL16 -0.959013717270803 5.95127281258643e-11 -1.60432144371953 0.000358012131553682 MirTarget -0.386374443244933 0.00879448960252585 NA NA NA hsa-let-7a-5p CCL3 -0.328069937201898 0.000464344093744051 -1.82654009873986 6.03403200682337e-16 TargetScan -0.291626028808082 0.0175931671617272 NA NA NA hsa-let-7b-5p CCNA2 -0.959013717270803 5.95127281258643e-11 3.36794922367745 6.53886370047174e-43 miRNAWalker2_validate;miRTarBase -0.524638048172729 1.97837367658696e-09 NA NA NA hsa-let-7b-5p CCNB1 -0.959013717270803 5.95127281258643e-11 3.15540953438863 5.73583669464518e-46 miRNAWalker2_validate -0.536702047843919 1.21768540248182e-11 NA NA NA hsa-let-7a-5p CCNB2 -0.328069937201898 0.000464344093744051 4.23615330954301 1.17296327500891e-51 miRNAWalker2_validate -0.449095168142698 0.00713886337518027 NA NA NA hsa-let-7b-5p CCNB2 -0.959013717270803 5.95127281258643e-11 4.23615330954301 1.17296327500891e-51 miRNAWalker2_validate -0.589177166241791 8.39990492744342e-09 NA NA NA hsa-let-7c-5p CCNB2 -1.70744661345097 2.87934212005942e-20 4.23615330954301 1.17296327500891e-51 miRNAWalker2_validate -0.85447689630769 1.64053136609545e-30 NA NA NA hsa-let-7a-5p CCNF -0.328069937201898 0.000464344093744051 2.17480980282222 4.71512834823536e-34 MirTarget;TargetScan -0.330534700891899 0.00114213691866937 NA NA NA hsa-let-7b-5p CCNF -0.959013717270803 5.95127281258643e-11 2.17480980282222 4.71512834823536e-34 miRNAWalker2_validate;MirTarget -0.340685407228666 5.04234056219806e-08 NA NA NA hsa-let-7c-5p CCNF -1.70744661345097 2.87934212005942e-20 2.17480980282222 4.71512834823536e-34 miRNAWalker2_validate;MirTarget -0.504449149504788 2.14481709469935e-28 NA NA NA hsa-let-7b-5p CD2BP2 -0.959013717270803 5.95127281258643e-11 0.561322845675346 1.37402577577802e-10 miRNAWalker2_validate -0.145953241597309 3.7392237188554e-07 NA NA NA hsa-let-7b-5p CD99 -0.959013717270803 5.95127281258643e-11 0.0600876200227471 0.615025077962687 miRNAWalker2_validate -0.135772513163603 0.000449196522509036 NA NA NA hsa-let-7a-5p CDC25A -0.328069937201898 0.000464344093744051 1.92057841155944 2.96621670231863e-18 MirTarget;TargetScan;miRNATAP -0.264057888419287 0.0286905010756172 NA NA NA hsa-let-7b-5p CDC25A -0.959013717270803 5.95127281258643e-11 1.92057841155944 2.96621670231863e-18 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.370009596159664 6.17259890107862e-07 NA NA NA hsa-let-7c-5p CDC25A -1.70744661345097 2.87934212005942e-20 1.92057841155944 2.96621670231863e-18 MirTarget -0.51524439141821 8.99192957021977e-21 25909324 MicroRNA let 7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma; The aim of the present study was to determine whether the cell cycle regulator CDC25A is involved in the antitumor effect of let-7c in HCC; The luciferase reporter assay showed that CDC25A was a direct target of let-7c and that let-7c inhibited the expression of CDC25A protein by directly targeting its 3' UTR; In conclusion this study indicates that let-7c suppresses HCC progression possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules progression liver cancer hsa-let-7a-5p CDC25B -0.328069937201898 0.000464344093744051 0.802575978153976 1.68584041760539e-08 miRNAWalker2_validate -0.209265115474151 0.00570595808420343 NA NA NA hsa-let-7a-5p CDC34 -0.328069937201898 0.000464344093744051 -0.101125489024096 0.330324468718084 miRTarBase;MirTarget;TargetScan;miRNATAP -0.229849473386734 1.9653658354634e-05 NA NA NA hsa-let-7b-5p CDC34 -0.959013717270803 5.95127281258643e-11 -0.101125489024096 0.330324468718084 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.126148768273998 0.000172798631521586 NA NA NA hsa-let-7d-5p CDC34 0.0503292020123807 0.702580311853671 -0.101125489024096 0.330324468718084 MirTarget;miRNATAP -0.101277272248805 0.00856612404572012 NA NA NA hsa-let-7a-5p CDCA8 -0.328069937201898 0.000464344093744051 3.14666984499479 3.07849548547044e-44 TargetScan -0.294064159976624 0.0259745299476609 NA NA NA hsa-let-7b-5p CDCA8 -0.959013717270803 5.95127281258643e-11 3.14666984499479 3.07849548547044e-44 miRNAWalker2_validate -0.418671529038396 2.45995507501178e-07 NA NA NA hsa-let-7b-5p CDIPT -0.959013717270803 5.95127281258643e-11 -0.0219450443698515 0.818857527125359 miRNAWalker2_validate -0.11061509856265 0.000354937859548354 NA NA NA hsa-let-7b-5p CDK6 -0.959013717270803 5.95127281258643e-11 -0.306731100792328 0.220566158555725 miRNAWalker2_validate;miRTarBase -0.21783266130525 0.0075638804735268 NA NA NA hsa-let-7c-5p CECR6 -1.70744661345097 2.87934212005942e-20 0.392226039618319 0.0399877472539567 MirTarget -0.145473456803039 0.00240190908970139 NA NA NA hsa-let-7d-5p CEP120 0.0503292020123807 0.702580311853671 -0.38529251765269 1.61409004225275e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.107810383415879 0.00123627651356974 NA NA NA hsa-let-7c-5p CEP135 -1.70744661345097 2.87934212005942e-20 0.275453361086419 0.0378107269841227 MirTarget -0.128226314386056 0.000108910151993848 NA NA NA hsa-let-7c-5p CERCAM -1.70744661345097 2.87934212005942e-20 -0.11834200381201 0.648161793551643 MirTarget -0.138379572621477 0.0336460392243724 NA NA NA hsa-let-7d-5p CGNL1 0.0503292020123807 0.702580311853671 -0.689721441130922 0.000385211746522737 MirTarget;miRNATAP -0.159119506424369 0.0288976016618257 NA NA NA hsa-let-7b-5p CHAF1A -0.959013717270803 5.95127281258643e-11 1.46563769387496 1.7819488179822e-31 miRNAWalker2_validate -0.212588358246169 1.16883431369167e-06 NA NA NA hsa-let-7b-5p CHD7 -0.959013717270803 5.95127281258643e-11 0.374421521974899 0.00251042980327692 miRNAWalker2_validate -0.133030508033276 0.000984762626258369 NA NA NA hsa-let-7b-5p CHMP2A -0.959013717270803 5.95127281258643e-11 0.285210488676931 0.0108221342721933 miRNAWalker2_validate -0.167202422089598 3.7811999062327e-06 NA NA NA hsa-let-7b-5p CHRAC1 -0.959013717270803 5.95127281258643e-11 0.329841039050446 0.000390283990359264 miRNAWalker2_validate -0.11779492288862 9.78269571494085e-05 NA NA NA hsa-let-7a-5p CHRD -0.328069937201898 0.000464344093744051 -0.0343248296218492 0.860981083059556 MirTarget;TargetScan;miRNATAP -0.307095000525603 0.0026964092650423 NA NA NA hsa-let-7b-5p CHRD -0.959013717270803 5.95127281258643e-11 -0.0343248296218492 0.860981083059556 MirTarget;miRNATAP -0.190639630022856 0.00276112583394826 NA NA NA hsa-let-7d-5p CHRD 0.0503292020123807 0.702580311853671 -0.0343248296218492 0.860981083059556 MirTarget;miRNATAP -0.273292046321681 0.000163958128976676 NA NA NA hsa-let-7b-5p CIZ1 -0.959013717270803 5.95127281258643e-11 0.656356544744201 1.88148960559807e-15 miRNAWalker2_validate -0.150689086176704 3.74161157593289e-08 NA NA NA hsa-let-7b-5p CKAP2 -0.959013717270803 5.95127281258643e-11 1.28759797972928 6.29803266196549e-19 miRNAWalker2_validate -0.181042942264551 0.000230183613382704 NA NA NA hsa-let-7b-5p CKS2 -0.959013717270803 5.95127281258643e-11 1.22161912236801 9.21069810140807e-16 miRNAWalker2_validate -0.297781868518535 3.71083324564015e-09 NA NA NA hsa-let-7b-5p CLDN12 -0.959013717270803 5.95127281258643e-11 -0.374004014225565 0.00034798002039704 MirTarget;miRNATAP -0.100450751628705 0.00327861629472694 NA NA NA hsa-let-7d-5p CLDN12 0.0503292020123807 0.702580311853671 -0.374004014225565 0.00034798002039704 MirTarget;miRNATAP -0.166807289030703 1.70369625935934e-05 NA NA NA hsa-let-7b-5p CMC1 -0.959013717270803 5.95127281258643e-11 0.291827935225109 0.00196527149345877 miRNAWalker2_validate -0.274728251332326 7.23432448069619e-21 NA NA NA hsa-let-7c-5p CNOT3 -1.70744661345097 2.87934212005942e-20 0.579019484348105 2.78881715385032e-17 miRNAWalker2_validate -0.137147538185394 1.56310657094192e-15 NA NA NA hsa-let-7b-5p COIL -0.959013717270803 5.95127281258643e-11 0.375360096456647 6.86455762932201e-08 miRNAWalker2_validate;miRNATAP -0.138220647238638 7.60687340575448e-10 NA NA NA hsa-let-7a-5p COL24A1 -0.328069937201898 0.000464344093744051 2.07152152023539 2.94685578585709e-08 MirTarget;TargetScan -0.590030165333622 0.00300593478246332 NA NA NA hsa-let-7b-5p COL24A1 -0.959013717270803 5.95127281258643e-11 2.07152152023539 2.94685578585709e-08 MirTarget -0.579552788503487 2.34196568220387e-06 NA NA NA hsa-let-7c-5p COL24A1 -1.70744661345097 2.87934212005942e-20 2.07152152023539 2.94685578585709e-08 MirTarget -0.322074263479633 0.000715997285583281 NA NA NA hsa-let-7d-5p COL24A1 0.0503292020123807 0.702580311853671 2.07152152023539 2.94685578585709e-08 MirTarget -0.606844059530845 1.56406994192539e-05 NA NA NA hsa-let-7b-5p COL4A5 -0.959013717270803 5.95127281258643e-11 0.0635599577482339 0.881381174188716 miRNATAP -0.312326835684194 0.0244834997460144 NA NA NA hsa-let-7a-5p COL9A1 -0.328069937201898 0.000464344093744051 2.78909880839119 5.63828792375664e-23 TargetScan -0.373420596193496 0.0171196761351436 NA NA NA hsa-let-7b-5p COMMD9 -0.959013717270803 5.95127281258643e-11 0.249145378307771 0.00304963862513706 miRNAWalker2_validate -0.174656670507027 7.33008174854526e-11 NA NA NA hsa-let-7a-5p COPZ1 -0.328069937201898 0.000464344093744051 0.352575593813907 8.28325520578983e-08 miRNAWalker2_validate -0.225931876157835 2.85933184740317e-11 NA NA NA hsa-let-7b-5p COX7B -0.959013717270803 5.95127281258643e-11 0.198852831282073 0.0880969272457646 miRNAWalker2_validate -0.157380989854236 2.97734095695068e-05 NA NA NA hsa-let-7b-5p CPSF1 -0.959013717270803 5.95127281258643e-11 0.752138209695792 1.09517148279778e-13 miRNAWalker2_validate -0.194360686698943 5.96007576700077e-09 NA NA NA hsa-let-7b-5p CPSF3L -0.959013717270803 5.95127281258643e-11 0.174702591510806 0.0301689752967918 miRNAWalker2_validate -0.158959029641571 6.04146836855132e-10 NA NA NA hsa-let-7a-5p CPSF4 -0.328069937201898 0.000464344093744051 0.77988036729674 7.78075887976318e-16 TargetScan -0.265754523962939 2.94162651650267e-07 NA NA NA hsa-let-7a-5p CS -0.328069937201898 0.000464344093744051 0.630496195920363 1.14583127791941e-12 miRNAWalker2_validate -0.10450808393208 0.0282939810607703 NA NA NA hsa-let-7b-5p CS -0.959013717270803 5.95127281258643e-11 0.630496195920363 1.14583127791941e-12 miRNAWalker2_validate -0.122943544990655 2.94487349216262e-05 NA NA NA hsa-let-7b-5p CSNK1D -0.959013717270803 5.95127281258643e-11 0.4731959867792 3.43904217952384e-13 miRNAWalker2_validate -0.191856445994201 1.75913960457771e-20 NA NA NA hsa-let-7c-5p CSNK2A1 -1.70744661345097 2.87934212005942e-20 0.311613292322925 6.17228757339028e-05 miRNAWalker2_validate -0.118081213291704 8.22763425873157e-10 NA NA NA hsa-let-7a-5p CYB561D1 -0.328069937201898 0.000464344093744051 1.35618855619484 4.53684308721849e-24 MirTarget;TargetScan;miRNATAP -0.213395029727319 0.00406401370317459 NA NA NA hsa-let-7b-5p CYB561D1 -0.959013717270803 5.95127281258643e-11 1.35618855619484 4.53684308721849e-24 MirTarget;miRNATAP -0.160151376551456 0.000514499606593881 NA NA NA hsa-let-7c-5p CYB561D1 -1.70744661345097 2.87934212005942e-20 1.35618855619484 4.53684308721849e-24 MirTarget -0.301970204704956 9.88527966067797e-19 NA NA NA hsa-let-7a-5p CYP19A1 -0.328069937201898 0.000464344093744051 1.83361302420833 2.08463700012796e-05 TargetScan -0.64300033910961 0.00475365992688912 NA NA NA hsa-let-7d-5p CYP4F2 0.0503292020123807 0.702580311853671 -2.73938992799869 1.81351729790839e-11 MirTarget -0.528641948824028 0.00066123669898411 NA NA NA hsa-let-7a-5p DAGLA -0.328069937201898 0.000464344093744051 1.16197262256378 7.56867119602314e-06 MirTarget;TargetScan;miRNATAP -0.362463401649787 0.00833080589625943 NA NA NA hsa-let-7c-5p DAGLA -1.70744661345097 2.87934212005942e-20 1.16197262256378 7.56867119602314e-06 MirTarget -0.448159334629883 3.0762615596391e-12 NA NA NA hsa-let-7c-5p DCAF15 -1.70744661345097 2.87934212005942e-20 0.442903624361357 6.04251738050238e-08 MirTarget -0.101335020598812 8.14528075667905e-07 NA NA NA hsa-let-7c-5p DCLRE1B -1.70744661345097 2.87934212005942e-20 0.715031438649862 1.3174682860474e-13 MirTarget -0.114154467810837 3.88086854753268e-06 NA NA NA hsa-let-7c-5p DCTN5 -1.70744661345097 2.87934212005942e-20 0.109069264850494 0.145747375920191 miRNAWalker2_validate -0.137050765086275 4.53587636121251e-14 NA NA NA hsa-let-7b-5p DCTPP1 -0.959013717270803 5.95127281258643e-11 0.556396532168848 1.11065960155029e-08 miRNAWalker2_validate -0.156161719315062 9.72304922739111e-07 NA NA NA hsa-let-7b-5p DDA1 -0.959013717270803 5.95127281258643e-11 0.436457331280509 1.13774933904213e-08 mirMAP -0.150367804615794 1.29904507283857e-09 NA NA NA hsa-let-7d-5p DDX19A 0.0503292020123807 0.702580311853671 -0.234237879401819 0.00059517928857285 MirTarget -0.121678149689517 1.24484374892521e-06 NA NA NA hsa-let-7d-5p DDX19B 0.0503292020123807 0.702580311853671 -0.838449294541977 7.27555351097906e-22 MirTarget -0.18243612786658 5.90948549746922e-08 NA NA NA hsa-let-7b-5p DDX28 -0.959013717270803 5.95127281258643e-11 -0.269338628660744 0.00440697880125603 miRNAWalker2_validate -0.117707159059545 0.000124849846049314 NA NA NA hsa-let-7b-5p DDX41 -0.959013717270803 5.95127281258643e-11 0.672632087768174 7.2549659944218e-18 miRNAWalker2_validate -0.194227263960645 3.63133743335956e-14 NA NA NA hsa-let-7b-5p DDX49 -0.959013717270803 5.95127281258643e-11 0.77500862560241 9.88785538395415e-17 miRNAWalker2_validate -0.209100035614149 1.12169488746364e-11 NA NA NA hsa-let-7b-5p DFFA -0.959013717270803 5.95127281258643e-11 0.0678724457086854 0.419098982330631 miRNAWalker2_validate -0.107067404976435 7.69501690805216e-05 NA NA NA hsa-let-7b-5p DHX16 -0.959013717270803 5.95127281258643e-11 0.396529304382273 1.41406159149443e-08 miRNAWalker2_validate -0.118820879313736 1.77840233200636e-07 NA NA NA hsa-let-7b-5p DHX57 -0.959013717270803 5.95127281258643e-11 0.896486446344413 1.50911053910984e-28 miRNAWalker2_validate -0.196112319960632 8.63503560522865e-13 NA NA NA hsa-let-7a-5p DIAPH3 -0.328069937201898 0.000464344093744051 3.40810304475021 2.20268130608007e-38 miRNATAP -0.433646934969038 0.00420541539958445 NA NA NA hsa-let-7b-5p DIAPH3 -0.959013717270803 5.95127281258643e-11 3.40810304475021 2.20268130608007e-38 miRNATAP -0.567081715712978 9.30576301669143e-10 NA NA NA hsa-let-7b-5p DLAT -0.959013717270803 5.95127281258643e-11 0.15422555346858 0.166263596135679 miRNAWalker2_validate -0.125305865771169 0.000519001380291536 NA NA NA hsa-let-7a-5p DLGAP4 -0.328069937201898 0.000464344093744051 0.616384781844966 4.24155614328603e-13 MirTarget;TargetScan -0.122281690487734 0.0074324061957137 NA NA NA hsa-let-7c-5p DLGAP4 -1.70744661345097 2.87934212005942e-20 0.616384781844966 4.24155614328603e-13 MirTarget -0.178146649866821 2.96101504576869e-17 NA NA NA hsa-let-7d-5p DNAJA2 0.0503292020123807 0.702580311853671 -0.306446654215278 0.000859844830484026 miRNATAP -0.18046686546763 9.64468810544559e-08 NA NA NA hsa-let-7a-5p DNAJC6 -0.328069937201898 0.000464344093744051 2.31761593888368 5.40782208875271e-21 miRNAWalker2_validate -0.455182944740199 0.000778467548997666 NA NA NA hsa-let-7c-5p DNAJC6 -1.70744661345097 2.87934212005942e-20 2.31761593888368 5.40782208875271e-21 miRNAWalker2_validate -0.383639320555159 2.04522452132374e-09 NA NA NA hsa-let-7b-5p DNAJC8 -0.959013717270803 5.95127281258643e-11 0.142275321235212 0.0284121881252851 miRNAWalker2_validate -0.116717428269637 1.73082932148394e-08 NA NA NA hsa-let-7a-5p DOCK3 -0.328069937201898 0.000464344093744051 1.89917396490138 8.65073654235979e-17 TargetScan;miRNATAP -0.452980248532519 0.000254557686385594 NA NA NA hsa-let-7b-5p DOCK3 -0.959013717270803 5.95127281258643e-11 1.89917396490138 8.65073654235979e-17 miRNATAP -0.385367462979767 4.74383763502925e-07 NA NA NA hsa-let-7c-5p DOT1L -1.70744661345097 2.87934212005942e-20 0.585703387018246 2.71031330751421e-07 miRNAWalker2_validate -0.149931329292625 1.58114052310453e-07 NA NA NA hsa-let-7a-5p DPH3 -0.328069937201898 0.000464344093744051 0.156886414904455 0.0299394459953927 TargetScan -0.207188174805358 2.37688640438887e-08 NA NA NA hsa-let-7a-5p DPH5 -0.328069937201898 0.000464344093744051 0.238038771019104 0.00425504406904555 miRNAWalker2_validate -0.153347212008767 0.000412027634638593 NA NA NA hsa-let-7a-5p DPP3 -0.328069937201898 0.000464344093744051 0.367930824003208 7.7340018984217e-06 TargetScan -0.172316872745624 6.38462862212304e-05 NA NA NA hsa-let-7b-5p DRG2 -0.959013717270803 5.95127281258643e-11 0.433961944830659 1.1606687167441e-05 miRNAWalker2_validate -0.1523127344821 2.21142256345983e-06 NA NA NA hsa-let-7a-5p DTX2 -0.328069937201898 0.000464344093744051 0.389172276410069 4.17637328390514e-06 TargetScan;miRNATAP -0.232954789846634 1.21652641686096e-07 NA NA NA hsa-let-7b-5p DTX2 -0.959013717270803 5.95127281258643e-11 0.389172276410069 4.17637328390514e-06 miRNATAP -0.119340242909356 1.47736989684342e-05 NA NA NA hsa-let-7b-5p DUSP12 -0.959013717270803 5.95127281258643e-11 0.889319942394092 2.74475464860036e-23 miRNAWalker2_validate -0.122218020588916 6.39744782242736e-05 NA NA NA hsa-let-7d-5p DUSP16 0.0503292020123807 0.702580311853671 -0.91339878293532 2.52773648393564e-12 miRNATAP -0.103888343680951 0.0374234673724865 NA NA NA hsa-let-7a-5p DUSP22 -0.328069937201898 0.000464344093744051 0.296163158728697 0.00143409958786832 TargetScan -0.224508113574101 3.32234048377662e-06 NA NA NA hsa-let-7b-5p DUSP23 -0.959013717270803 5.95127281258643e-11 0.498053767380336 0.000630870205797103 miRNAWalker2_validate -0.238447321455828 4.31615192811961e-07 NA NA NA hsa-let-7a-5p DUSP9 -0.328069937201898 0.000464344093744051 3.1269142024265 1.25405437803303e-16 TargetScan;miRNATAP -0.734018037050491 0.000344246692768342 NA NA NA hsa-let-7b-5p DUSP9 -0.959013717270803 5.95127281258643e-11 3.1269142024265 1.25405437803303e-16 miRNATAP -0.67382263873815 9.82794071016697e-08 NA NA NA hsa-let-7c-5p DZIP1L -1.70744661345097 2.87934212005942e-20 -0.0817102374066513 0.728597088782924 MirTarget -0.153365860262585 0.00940939013868638 NA NA NA hsa-let-7a-5p E2F1 -0.328069937201898 0.000464344093744051 3.7552527009539 6.33758772261827e-48 miRNAWalker2_validate -0.451450780631698 0.00302856569262514 NA NA NA hsa-let-7a-5p E2F2 -0.328069937201898 0.000464344093744051 2.82262179260901 6.90997126839698e-33 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.313426065416331 0.0196862910836674 20418948;25647078 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2;Tumor suppressive microRNA let 7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells; When let-7a was transfected into OS cell lines the expression of E2F2 in the cells was greatly suppressed suggesting that E2F2 is a target of miRNA-let-7a in OS cells ; prostate cancer;sarcoma hsa-let-7b-5p E2F2 -0.959013717270803 5.95127281258643e-11 2.82262179260901 6.90997126839698e-33 MirTarget -0.371169195680849 7.55477650894117e-06 NA NA NA hsa-let-7c-5p E2F2 -1.70744661345097 2.87934212005942e-20 2.82262179260901 6.90997126839698e-33 MirTarget -0.605641654221748 3.1290897462579e-23 NA NA NA hsa-let-7a-5p E2F5 -0.328069937201898 0.000464344093744051 0.730554652437087 0.000401890915871585 MirTarget;TargetScan;miRNATAP -0.388478797116257 0.00033740750885559 NA NA NA hsa-let-7b-5p E2F5 -0.959013717270803 5.95127281258643e-11 0.730554652437087 0.000401890915871585 miRNAWalker2_validate;MirTarget;miRNATAP -0.21870636746378 0.00120101767570817 NA NA NA hsa-let-7c-5p E2F5 -1.70744661345097 2.87934212005942e-20 0.730554652437087 0.000401890915871585 MirTarget -0.228095461415917 1.04748751614991e-05 NA NA NA hsa-let-7a-5p E2F6 -0.328069937201898 0.000464344093744051 0.329712583456323 5.20721454340624e-05 TargetScan;miRNATAP -0.168951424828348 7.31174255843305e-05 NA NA NA hsa-let-7b-5p E2F6 -0.959013717270803 5.95127281258643e-11 0.329712583456323 5.20721454340624e-05 miRNAWalker2_validate;miRNATAP -0.176960673576418 1.06706239053999e-11 NA NA NA hsa-let-7b-5p E2F7 -0.959013717270803 5.95127281258643e-11 3.06815276582178 3.19808997821633e-30 miRNAWalker2_validate -0.339915171018582 0.00029805189931151 NA NA NA hsa-let-7b-5p EEF1E1 -0.959013717270803 5.95127281258643e-11 0.629314991668398 9.25270018504777e-09 miRNAWalker2_validate -0.187050748724466 1.79797497011245e-07 NA NA NA hsa-let-7a-5p EGLN2 -0.328069937201898 0.000464344093744051 0.403657237847275 3.81970813899137e-05 TargetScan -0.147651843747427 0.00420314723565415 NA NA NA hsa-let-7b-5p EIF2AK1 -0.959013717270803 5.95127281258643e-11 0.0884340451956707 0.159248628246424 miRNAWalker2_validate -0.100730695395856 5.1923827767891e-07 NA NA NA hsa-let-7a-5p EIF2B2 -0.328069937201898 0.000464344093744051 0.317883805639215 9.53541023515029e-06 TargetScan -0.126489050490638 0.000779827967131519 NA NA NA hsa-let-7b-5p EIF2B3 -0.959013717270803 5.95127281258643e-11 -0.0754584717749021 0.423611291633578 miRNAWalker2_validate -0.17297203684419 9.33779996153183e-09 NA NA NA hsa-let-7a-5p EIF2S2 -0.328069937201898 0.000464344093744051 0.317957817884656 2.49059742366842e-05 TargetScan -0.249247592625557 1.37968483647114e-10 NA NA NA hsa-let-7b-5p EIF3D -0.959013717270803 5.95127281258643e-11 0.472924158785482 6.41890771476853e-08 miRNAWalker2_validate -0.133619959300833 2.96181009162218e-06 NA NA NA hsa-let-7b-5p EIF4A1 -0.959013717270803 5.95127281258643e-11 -0.0811925524357768 0.439473537122939 miRNAWalker2_validate -0.10578599992662 0.00188719686496599 NA NA NA hsa-let-7c-5p ELF4 -1.70744661345097 2.87934212005942e-20 -0.129534848954421 0.489734019401336 MirTarget -0.135890153838811 0.0038215332500121 NA NA NA hsa-let-7b-5p ELOVL1 -0.959013717270803 5.95127281258643e-11 0.772132123121458 7.40013744177412e-22 miRNAWalker2_validate -0.123132869933116 6.28427566213491e-06 NA NA NA hsa-let-7b-5p ENTPD6 -0.959013717270803 5.95127281258643e-11 0.82438097086137 1.05530499623752e-16 miRNAWalker2_validate -0.108438351942778 0.00120884217835417 NA NA NA hsa-let-7d-5p ERCC4 0.0503292020123807 0.702580311853671 -0.398490625556519 0.000316330847829454 MirTarget;miRNATAP -0.123021042125108 0.002892788978267 NA NA NA hsa-let-7a-5p ERGIC2 -0.328069937201898 0.000464344093744051 -0.0964112626167406 0.202552847740749 TargetScan -0.122308886918416 0.00186165269347282 NA NA NA hsa-let-7b-5p ERGIC3 -0.959013717270803 5.95127281258643e-11 0.201435796069729 0.0126399095387613 miRNAWalker2_validate -0.155970706761873 1.47695172843721e-09 NA NA NA hsa-let-7b-5p ESPL1 -0.959013717270803 5.95127281258643e-11 1.87757313624794 3.45937181689806e-13 MirTarget -0.23517623264085 0.00664457544852015 NA NA NA hsa-let-7c-5p ESPL1 -1.70744661345097 2.87934212005942e-20 1.87757313624794 3.45937181689806e-13 MirTarget -0.45417008213531 3.14084416633658e-12 NA NA NA hsa-let-7d-5p ETNK2 0.0503292020123807 0.702580311853671 -1.42301778283554 7.52967048096134e-07 miRNATAP -0.533002870588644 6.88351762730703e-07 NA NA NA hsa-let-7b-5p EZH2 -0.959013717270803 5.95127281258643e-11 2.56936752791081 3.12233537592977e-46 miRNATAP -0.273053829571765 2.98029088605658e-05 25611389 Significant inverse correlation between EZH2 and hsa-miR-26a-5p R2=0.56 P=0.0001 and hsa-let-7b-5p R2=0.19 P=0.02 expression was observed in the same samples corroborating the belief of EZH2 being a bona fide target for these two miRNAs in CRC colorectal cancer hsa-let-7a-5p FADS3 -0.328069937201898 0.000464344093744051 0.510816048568569 1.97528880588502e-05 TargetScan -0.29172938264323 3.1672221642007e-06 NA NA NA hsa-let-7a-5p FAM103A1 -0.328069937201898 0.000464344093744051 0.489844961593656 1.4777880039426e-09 TargetScan -0.181944602006191 2.12952893928941e-05 NA NA NA hsa-let-7c-5p FAM103A1 -1.70744661345097 2.87934212005942e-20 0.489844961593656 1.4777880039426e-09 miRNAWalker2_validate -0.146424524120768 3.23230414839587e-13 NA NA NA hsa-let-7a-5p FAM104A -0.328069937201898 0.000464344093744051 0.382548867340036 2.14628142056169e-09 MirTarget;TargetScan;miRNATAP -0.138195362383357 4.03264513964067e-05 NA NA NA hsa-let-7b-5p FAM104A -0.959013717270803 5.95127281258643e-11 0.382548867340036 2.14628142056169e-09 MirTarget;miRNATAP -0.161887276166608 1.97459896699949e-15 NA NA NA hsa-let-7c-5p FAM104A -1.70744661345097 2.87934212005942e-20 0.382548867340036 2.14628142056169e-09 MirTarget -0.10225823892978 1.28559987604419e-10 NA NA NA hsa-let-7b-5p FAM136A -0.959013717270803 5.95127281258643e-11 0.203629475672582 0.019862370683348 miRNAWalker2_validate -0.17445856805105 3.95584010767527e-10 NA NA NA hsa-let-7a-5p FAM160B2 -0.328069937201898 0.000464344093744051 0.170041130884332 0.0540544370833985 TargetScan;miRNATAP -0.112620985831264 0.014571662871803 NA NA NA hsa-let-7b-5p FAM49B -0.959013717270803 5.95127281258643e-11 0.706283783396553 6.55052138725098e-10 miRNAWalker2_validate -0.17760813947684 2.3748362950461e-06 NA NA NA hsa-let-7b-5p FANCD2 -0.959013717270803 5.95127281258643e-11 2.42525506695471 5.51548958189464e-31 miRNAWalker2_validate -0.358677319176402 8.80535655200501e-07 NA NA NA hsa-let-7c-5p FANCI -1.70744661345097 2.87934212005942e-20 2.58883645204084 1.64497704333454e-42 miRNAWalker2_validate -0.553264627084958 3.44910425383123e-29 NA NA NA hsa-let-7a-5p FARSA -0.328069937201898 0.000464344093744051 0.256704894019852 0.000483396422744749 miRNAWalker2_validate -0.192417350022187 4.37086568995009e-07 NA NA NA hsa-let-7a-5p FASTK -0.328069937201898 0.000464344093744051 0.648485924830869 3.52274456747897e-11 TargetScan -0.237245086691099 4.97978823248534e-06 NA NA NA hsa-let-7a-5p FBXL19 -0.328069937201898 0.000464344093744051 1.09129763767905 3.05430880690495e-25 TargetScan;miRNATAP -0.189586295910636 0.00114504817295859 NA NA NA hsa-let-7b-5p FBXL19 -0.959013717270803 5.95127281258643e-11 1.09129763767905 3.05430880690495e-25 miRNATAP -0.117448664686965 0.00120549273557833 NA NA NA hsa-let-7a-5p FBXO32 -0.328069937201898 0.000464344093744051 1.49973264070402 1.35888111194844e-11 TargetScan;miRNATAP -0.408608217233986 0.000583968456002134 NA NA NA hsa-let-7b-5p FBXO32 -0.959013717270803 5.95127281258643e-11 1.49973264070402 1.35888111194844e-11 miRNATAP -0.3485130972578 2.09750759880799e-06 NA NA NA hsa-let-7b-5p FEN1 -0.959013717270803 5.95127281258643e-11 1.51032173359862 2.85003232854286e-30 miRNAWalker2_validate -0.209432375051581 5.17009195714609e-06 NA NA NA hsa-let-7a-5p FGF11 -0.328069937201898 0.000464344093744051 0.213353925569267 0.274831508108713 TargetScan;mirMAP;miRNATAP -0.205257761608876 0.045024100259283 NA NA NA hsa-let-7a-5p FIGNL2 -0.328069937201898 0.000464344093744051 1.38863525177439 4.36348606427085e-07 MirTarget -0.330130331872507 0.0238726933707154 NA NA NA hsa-let-7b-5p FIGNL2 -0.959013717270803 5.95127281258643e-11 1.38863525177439 4.36348606427085e-07 MirTarget -0.292977132140403 0.00122805071001228 NA NA NA hsa-let-7c-5p FIGNL2 -1.70744661345097 2.87934212005942e-20 1.38863525177439 4.36348606427085e-07 MirTarget -0.440097760520244 1.38345498901364e-10 NA NA NA hsa-let-7c-5p FKBP10 -1.70744661345097 2.87934212005942e-20 0.164171258069953 0.48719948726372 miRNAWalker2_validate -0.199648875231396 0.00073149848136377 NA NA NA hsa-let-7a-5p FKBP8 -0.328069937201898 0.000464344093744051 0.155813885955391 0.0864524824893704 miRNAWalker2_validate -0.176915402339559 0.000179863037348189 NA NA NA hsa-let-7b-5p FLAD1 -0.959013717270803 5.95127281258643e-11 0.959874432929258 2.46982532348914e-23 miRNAWalker2_validate -0.149928596111594 5.16028085214006e-06 NA NA NA hsa-let-7d-5p FMO4 0.0503292020123807 0.702580311853671 -1.24749117913486 9.83691192348328e-09 MirTarget -0.265621915434861 0.00124572618524553 NA NA NA hsa-let-7b-5p FOXK1 -0.959013717270803 5.95127281258643e-11 1.204250755958 4.1435634806038e-25 miRNAWalker2_validate -0.121165890229899 0.00256861674702068 NA NA NA hsa-let-7b-5p FOXRED1 -0.959013717270803 5.95127281258643e-11 -0.452005067058947 1.14969078279801e-05 miRNAWalker2_validate -0.100638403221018 0.00289338300691967 NA NA NA hsa-let-7b-5p FOXRED2 -0.959013717270803 5.95127281258643e-11 0.577672963235982 1.33103553759756e-05 miRNAWalker2_validate -0.136854063040477 0.00166319127983456 NA NA NA hsa-let-7d-5p FZD4 0.0503292020123807 0.702580311853671 -0.346477770504521 0.0109747315056824 MirTarget;miRNATAP -0.118288031351343 0.0198943536737446 NA NA NA hsa-let-7a-5p GADD45GIP1 -0.328069937201898 0.000464344093744051 0.361813732020945 0.00922874858873187 miRNAWalker2_validate -0.410539436236791 1.0664511663855e-08 NA NA NA hsa-let-7a-5p GALE -0.328069937201898 0.000464344093744051 0.0213400851713859 0.851937605743634 TargetScan;miRNATAP -0.229730963789606 0.000109365597078717 NA NA NA hsa-let-7b-5p GALE -0.959013717270803 5.95127281258643e-11 0.0213400851713859 0.851937605743634 miRNATAP -0.199760410954877 4.92695775933867e-08 NA NA NA hsa-let-7d-5p GALE 0.0503292020123807 0.702580311853671 0.0213400851713859 0.851937605743634 miRNATAP -0.178015743047992 2.38179274322816e-05 NA NA NA hsa-let-7b-5p GAPDH -0.959013717270803 5.95127281258643e-11 0.480767917732015 7.88084504602343e-05 miRNAWalker2_validate -0.264455592607746 1.21327484001911e-11 NA NA NA hsa-let-7c-5p GARS -1.70744661345097 2.87934212005942e-20 0.53606930447414 1.66438816977997e-09 miRNAWalker2_validate -0.161680244524281 2.42584352025334e-13 NA NA NA hsa-let-7b-5p GATC -0.959013717270803 5.95127281258643e-11 0.0603112190540133 0.626598180192356 miRNAWalker2_validate -0.148215463441199 0.000220194717775111 NA NA NA hsa-let-7a-5p GEMIN7 -0.328069937201898 0.000464344093744051 0.501913524429603 3.4210444949634e-06 TargetScan -0.301837672238155 8.62391562915884e-08 NA NA NA hsa-let-7b-5p GEMIN7 -0.959013717270803 5.95127281258643e-11 0.501913524429603 3.4210444949634e-06 miRNAWalker2_validate -0.215277010531203 6.81286881400513e-10 NA NA NA hsa-let-7b-5p GFM2 -0.959013717270803 5.95127281258643e-11 -0.0966405936003545 0.265669870500178 miRNAWalker2_validate -0.126582716199385 5.82502151121516e-06 NA NA NA hsa-let-7a-5p GGA3 -0.328069937201898 0.000464344093744051 0.711679336404982 1.46861146142528e-21 MirTarget;miRNATAP -0.128725965349771 0.00163450949462409 NA NA NA hsa-let-7b-5p GGA3 -0.959013717270803 5.95127281258643e-11 0.711679336404982 1.46861146142528e-21 MirTarget;miRNATAP -0.183888304432629 1.11006920638413e-13 NA NA NA hsa-let-7c-5p GGA3 -1.70744661345097 2.87934212005942e-20 0.711679336404982 1.46861146142528e-21 MirTarget -0.172818653690179 3.02949988341581e-20 NA NA NA hsa-let-7b-5p GGCT -0.959013717270803 5.95127281258643e-11 0.468616710122449 1.69363511847243e-07 miRNAWalker2_validate -0.136900213937685 2.88679968501206e-06 NA NA NA hsa-let-7a-5p GIPC1 -0.328069937201898 0.000464344093744051 0.624638602966812 2.624912119742e-08 TargetScan;miRNATAP -0.203781837840433 0.000613960468031672 NA NA NA hsa-let-7b-5p GLO1 -0.959013717270803 5.95127281258643e-11 -0.103450783154576 0.294657159707284 miRNAWalker2_validate -0.141696620235471 8.35120376814853e-06 NA NA NA hsa-let-7a-5p GLRX -0.328069937201898 0.000464344093744051 -0.975673886303721 2.13364253566235e-08 MirTarget;TargetScan -0.208698689404828 0.0246352473818037 NA NA NA hsa-let-7b-5p GLRX -0.959013717270803 5.95127281258643e-11 -0.975673886303721 2.13364253566235e-08 MirTarget -0.126687132833893 0.0283981768994856 NA NA NA hsa-let-7d-5p GLRX 0.0503292020123807 0.702580311853671 -0.975673886303721 2.13364253566235e-08 MirTarget -0.375056704238545 7.50734260920704e-09 NA NA NA hsa-let-7b-5p GLTSCR2 -0.959013717270803 5.95127281258643e-11 0.0748797954216354 0.522855674293858 miRNAWalker2_validate -0.106586363793112 0.00509019313580031 NA NA NA hsa-let-7a-5p GNAL -0.328069937201898 0.000464344093744051 1.33283669629593 1.09261153741281e-06 TargetScan;miRNATAP -0.378421698680217 0.00909957720097428 NA NA NA hsa-let-7b-5p GNAL -0.959013717270803 5.95127281258643e-11 1.33283669629593 1.09261153741281e-06 miRNATAP -0.353559303180385 8.26429592853651e-05 NA NA NA hsa-let-7a-5p GNG5 -0.328069937201898 0.000464344093744051 0.00889434951085377 0.914434057152244 MirTarget;TargetScan;miRNATAP -0.133605931047702 0.00189613241874912 NA NA NA hsa-let-7b-5p GPATCH1 -0.959013717270803 5.95127281258643e-11 0.728774421513739 5.89778345723556e-20 miRNAWalker2_validate -0.128433540221975 1.72769628284449e-06 NA NA NA hsa-let-7a-5p GPATCH3 -0.328069937201898 0.000464344093744051 0.453802151942463 5.64385551333175e-07 TargetScan;miRNATAP -0.237813083549915 5.39314303866926e-07 NA NA NA hsa-let-7b-5p GPATCH3 -0.959013717270803 5.95127281258643e-11 0.453802151942463 5.64385551333175e-07 miRNATAP -0.218650025346378 4.50602893544746e-14 NA NA NA hsa-let-7b-5p GPATCH4 -0.959013717270803 5.95127281258643e-11 0.803721354481271 1.69122006641545e-14 miRNAWalker2_validate -0.135467870013055 0.000110632105748716 NA NA NA hsa-let-7b-5p GPR107 -0.959013717270803 5.95127281258643e-11 0.622929083702605 1.41671116678588e-13 mirMAP -0.11369823172133 4.99674304049494e-05 NA NA NA hsa-let-7b-5p GREB1 -0.959013717270803 5.95127281258643e-11 0.433971867548677 0.16750650822662 MirTarget;miRNATAP -0.340830978057304 0.000854581013646363 NA NA NA hsa-let-7b-5p GRIN3A -0.959013717270803 5.95127281258643e-11 0.454878285807011 0.000628666966444248 miRNATAP -0.114146033913625 0.0087532693367889 NA NA NA hsa-let-7a-5p GRPEL2 -0.328069937201898 0.000464344093744051 0.65712951992937 1.31065567027786e-19 MirTarget;TargetScan -0.154961113496614 8.303866166666e-05 NA NA NA hsa-let-7b-5p GRPEL2 -0.959013717270803 5.95127281258643e-11 0.65712951992937 1.31065567027786e-19 miRNAWalker2_validate;MirTarget -0.121045604935185 6.78920894220339e-07 NA NA NA hsa-let-7c-5p GRPEL2 -1.70744661345097 2.87934212005942e-20 0.65712951992937 1.31065567027786e-19 MirTarget -0.166885706843202 3.33866025922138e-20 NA NA NA hsa-let-7c-5p GSK3A -1.70744661345097 2.87934212005942e-20 0.346560250550711 1.83266290443851e-08 miRNAWalker2_validate -0.101608466684152 2.71277295275603e-11 NA NA NA hsa-let-7a-5p GTF3C5 -0.328069937201898 0.000464344093744051 0.419125796162832 1.00577542504161e-06 miRNAWalker2_validate -0.137888909641028 0.00228544541206621 NA NA NA hsa-let-7b-5p GTPBP3 -0.959013717270803 5.95127281258643e-11 0.591099664001016 5.06912996538586e-13 miRNAWalker2_validate -0.138684851884524 2.86884179904532e-07 NA NA NA hsa-let-7b-5p HABP4 -0.959013717270803 5.95127281258643e-11 0.383004886749933 0.0065168011083657 miRNATAP -0.306186271650963 9.10599931795906e-12 NA NA NA hsa-let-7d-5p HABP4 0.0503292020123807 0.702580311853671 0.383004886749933 0.0065168011083657 miRNATAP -0.180174343600009 0.000576423095753498 NA NA NA hsa-let-7b-5p HARS -0.959013717270803 5.95127281258643e-11 0.212417488358765 0.00591762165144976 miRNAWalker2_validate -0.160986042302941 5.55285476138052e-11 NA NA NA hsa-let-7b-5p HELLS -0.959013717270803 5.95127281258643e-11 2.62327787224869 1.35869467447747e-28 miRNAWalker2_validate -0.354349414040168 1.59334135234248e-05 NA NA NA hsa-let-7b-5p HGS -0.959013717270803 5.95127281258643e-11 0.903489845847178 4.32720959970448e-25 miRNAWalker2_validate -0.271182799211659 3.60893697905387e-21 NA NA NA hsa-let-7a-5p HIC2 -0.328069937201898 0.000464344093744051 0.940776893137958 6.46839631810595e-09 TargetScan;miRNATAP -0.220906444242877 0.0106019146250159 NA NA NA hsa-let-7b-5p HIC2 -0.959013717270803 5.95127281258643e-11 0.940776893137958 6.46839631810595e-09 miRNATAP -0.188335234590706 0.000442227706305347 NA NA NA hsa-let-7a-5p HIF1AN -0.328069937201898 0.000464344093744051 0.594006229178836 2.59789157148843e-12 MirTarget;TargetScan -0.169336394782436 0.000186189001733938 NA NA NA hsa-let-7b-5p HIF1AN -0.959013717270803 5.95127281258643e-11 0.594006229178836 2.59789157148843e-12 MirTarget -0.19054880654715 5.43746632456222e-12 NA NA NA hsa-let-7c-5p HIF1AN -1.70744661345097 2.87934212005942e-20 0.594006229178836 2.59789157148843e-12 MirTarget -0.147609310389359 4.12097290603693e-12 NA NA NA hsa-let-7d-5p HIF3A 0.0503292020123807 0.702580311853671 -0.432790060092153 0.111359222900488 mirMAP -0.278458865992817 0.00591363570726755 NA NA NA hsa-let-7b-5p HIST1H1C -0.959013717270803 5.95127281258643e-11 0.809397548723961 0.000555269225773258 miRNAWalker2_validate -0.445136991331824 3.8695810962006e-09 NA NA NA hsa-let-7d-5p HLF 0.0503292020123807 0.702580311853671 -1.56359740264692 3.39928227602253e-08 miRNATAP -0.363382099126395 0.00067875178751564 NA NA NA hsa-let-7a-5p HMGA1 -0.328069937201898 0.000464344093744051 1.52957485940098 1.79164981120061e-17 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.493406922180222 3.6352489107765e-07 NA NA NA hsa-let-7b-5p HMGA1 -0.959013717270803 5.95127281258643e-11 1.52957485940098 1.79164981120061e-17 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.294085992299031 1.13716915560745e-06 23798998 Furthermore we identified HMGA1 a non-histone protein as a new target of let-7b and found correlation of let-7b down-regulation with HMGA1 over-expression in primary PCa samples prostate cancer hsa-let-7c-5p HMGA1 -1.70744661345097 2.87934212005942e-20 1.52957485940098 1.79164981120061e-17 MirTarget -0.517651637702838 1.10830470288536e-32 NA NA NA hsa-let-7a-5p HMGA2 -0.328069937201898 0.000464344093744051 1.11519648679255 0.015940340984894 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.523067146124385 0.0315498002758721 20949044;18413822;23073586;21598109;24612219;23134218;23700794;21412931 Since let-7 miRNAs generally play a tumor-suppressive role as targeting oncogenes such as RAS and HMGA2 our results suggest that AZ-P7a cells release let-7 miRNAs via exosomes into the extracellular environment to maintain their oncogenesis;Recent studies report that HMGA2 is negatively regulated by the let-7 microRNA miRNA family; However no studies have examined the clinical significance of HMGA2 and its relationship to the let-7 miRNA family in gastric cancer; We also did an association study comparing HMGA2 expression and let-7 miRNA family expression in gastric cancer; An inverse correlation between HMGA2 and let-7a was found in gastric cancer cell lines P = 0.08; Furthermore our findings suggest that HMGA2 is negatively regulated by the let-7 miRNA family in human gastric cancer;HMGA2 mRNA and let-7 family microRNA were detected by real time fluorescent quantitative reverse transcription polymerase chain reaction in the corresponding frozen tissues; All let-7 family members were detectable in all ovarian cancer samples and their expression were inversely correlated with HMGA2 mRNA expression r=-0.305P<0.05; The downregulation of let-7 is but not the only mechanism of HMGA2 overexpression in serous ovarian cancer;Role of microRNA let 7 and effect to HMGA2 in esophageal squamous cell carcinoma; To investigated the role of microRNA miRNA let-7 and its regulation on high mobility group A2 HMGA2 protein expression in esophageal squamous cell carcinoma ESCC; To evaluate the role of let-7 and HMGA2 cell proliferations were analyzed with synthetic let-7 mimics- or its inhibitor-transfected cells; The transcription of let-7 inversely correlated with HMGA2 protein; The present results demonstrated that let-7 and HMGA2 involved in ESCC carcinogenesis;HMGA2 is down regulated by microRNA let 7 and associated with epithelial mesenchymal transition in oesophageal squamous cell carcinomas of Kazakhs; To investigate the expression of let-7 and its regulation of high-mobility group A2 protein HMGA2 and to verify the relationship between let-7 HMGA2 and the process of epithelial-mesenchymal transition EMT in oesophageal squamous cell carcinomas OSCC of Kazakh patients; Let-7 could repress expression of HMGA2 after co-transfection with let-7 and HMGA2 P = 0.002; Moreover let-7 expression was observed less frequently P = 2.0 × 10-8 and HMGA2 expression more frequently P = 1.0 × 10-10 in OSCC than in normal adjacent tissues; and let-7 expression was observed less frequently in OSCC from Kazakh patients than in those from Han and Uygur patients P = 0.041; There was a reverse correlation between expression of let-7 and HMGA2 P = 0.018; Expression of let-7 can suppress cell proliferation by acting directly on regulation of HMGA2 in OSCC;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;MiR-98 a member in the let-7 family acts as a negative regulator in the expression of HMGA2 high mobility group A2 oncogene and it has been shown to have a nearly 3-fold decrease in A549/DDP cells;Let 7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data; The aim of our study was first to assess the role of HMGA2 expression in the pathogenesis of adipocytic tumors AT and second to seek a potential correlation between overexpression of HMGA2 and let-7 expression inhibition by analyzing a series of 56 benign and malignant AT with molecular cytogenetic data; We measured the levels of expression of HMGA2 mRNA and of eight members of the let-7 microRNA family using quantitative RT-PCR and expression of HMGA2 protein using immunohistochemistry; Although overexpression of both HMGA2 mRNA and protein in a majority of ordinary lipomas without HMGA2 structural rearrangement may have suggested a potential role for let-7 microRNAs we did not observe a significant link with let-7 inhibition in such cases ;;;tumorigenesis;;;;malignant trasformation gastric cancer;gastric cancer;ovarian cancer;esophageal cancer;esophageal cancer;lung squamous cell cancer;lung cancer;sarcoma hsa-let-7c-5p HMGA2 -1.70744661345097 2.87934212005942e-20 1.11519648679255 0.015940340984894 miRNAWalker2_validate;miRTarBase;MirTarget -0.682135030438129 2.57681307834063e-09 NA NA NA hsa-let-7b-5p HMGCS1 -0.959013717270803 5.95127281258643e-11 0.177750721836838 0.325041585930265 miRNAWalker2_validate -0.182179199070234 0.00190880835914596 NA NA NA hsa-let-7a-5p HNRNPA1 -0.328069937201898 0.000464344093744051 0.655818468699744 1.34002254508707e-12 TargetScan -0.18165405811474 0.000240533220122959 NA NA NA hsa-let-7a-5p HRAS -0.328069937201898 0.000464344093744051 0.80680940319204 2.11618137601331e-10 miRNAWalker2_validate;miRTarBase -0.411742589318827 6.60009421951558e-10 20607356;23134218;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;;progression glioblastoma;lung squamous cell cancer;lung cancer;lung cancer;pancreatic cancer hsa-let-7b-5p HRAS -0.959013717270803 5.95127281258643e-11 0.80680940319204 2.11618137601331e-10 miRTarBase -0.270772577779286 5.9733154777202e-11 20607356;20881268;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;On the basis of these data we suggest that the downregulation of let-7b and let-7e targeting K-ras and the upregulation of miR-17* a CRC marker could be considered as candidate molecular markers of cetuximab resistance;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;drug resistance;;;progression glioblastoma;colorectal cancer;lung cancer;lung cancer;pancreatic cancer hsa-let-7b-5p HSF2 -0.959013717270803 5.95127281258643e-11 0.59187321228126 7.06161260636529e-09 miRNAWalker2_validate -0.134631849793446 6.34704461126863e-05 NA NA NA hsa-let-7b-5p HSPA1B -0.959013717270803 5.95127281258643e-11 0.500062250723722 0.0177938871093333 miRNAWalker2_validate -0.164902599418074 0.016758335232437 NA NA NA hsa-let-7b-5p HTT -0.959013717270803 5.95127281258643e-11 0.396234962853412 2.19371471763879e-06 miRNAWalker2_validate -0.100518104460298 0.000239839645834329 NA NA NA hsa-let-7a-5p ICOS -0.328069937201898 0.000464344093744051 0.273488185914632 0.356367830019625 TargetScan -0.307426239094412 0.0480113714208262 NA NA NA hsa-let-7b-5p IDI1 -0.959013717270803 5.95127281258643e-11 0.241163626861236 0.0915726955955609 miRNAWalker2_validate -0.137082180911079 0.0031952349216371 NA NA NA hsa-let-7b-5p IFRD1 -0.959013717270803 5.95127281258643e-11 0.558738711971646 9.00080994709618e-08 miRNAWalker2_validate -0.116488184453232 0.000711533421951735 NA NA NA hsa-let-7a-5p IGDCC3 -0.328069937201898 0.000464344093744051 1.93021594033306 4.85774469918296e-06 MirTarget;TargetScan;miRNATAP -0.630307408420545 0.00481600576643458 NA NA NA hsa-let-7b-5p IGDCC3 -0.959013717270803 5.95127281258643e-11 1.93021594033306 4.85774469918296e-06 MirTarget;miRNATAP -0.634298862446369 4.32729944300096e-06 NA NA NA hsa-let-7c-5p IGDCC3 -1.70744661345097 2.87934212005942e-20 1.93021594033306 4.85774469918296e-06 MirTarget -0.631731378965707 2.0749328122547e-09 NA NA NA hsa-let-7c-5p IGDCC4 -1.70744661345097 2.87934212005942e-20 1.73062068710294 1.15353341113415e-06 MirTarget -0.669489234913257 2.47646431218122e-14 NA NA NA hsa-let-7a-5p IGF2BP1 -0.328069937201898 0.000464344093744051 4.99826974747196 9.59227871105866e-16 miRTarBase;MirTarget;TargetScan;miRNATAP -1.34940699398838 6.04581980965503e-05 NA NA NA hsa-let-7b-5p IGF2BP1 -0.959013717270803 5.95127281258643e-11 4.99826974747196 9.59227871105866e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.945796008679475 5.90409297909599e-06 NA NA NA hsa-let-7c-5p IGF2BP1 -1.70744661345097 2.87934212005942e-20 4.99826974747196 9.59227871105866e-16 MirTarget -1.64306107284158 3.32791048956517e-27 NA NA NA hsa-let-7c-5p IGF2BP2 -1.70744661345097 2.87934212005942e-20 1.1359757160287 0.0039471483972338 MirTarget -0.66967665441044 5.02308301505737e-12 NA NA NA hsa-let-7a-5p IGF2BP3 -0.328069937201898 0.000464344093744051 2.42884018072337 1.74029814218083e-12 MirTarget;TargetScan -0.772884314436813 2.7597326545302e-05 NA NA NA hsa-let-7b-5p IGF2BP3 -0.959013717270803 5.95127281258643e-11 2.42884018072337 1.74029814218083e-12 miRNAWalker2_validate;MirTarget -0.643469022367535 1.53553592547173e-08 NA NA NA hsa-let-7c-5p IGF2BP3 -1.70744661345097 2.87934212005942e-20 2.42884018072337 1.74029814218083e-12 MirTarget -0.792505127678787 9.55879338832913e-21 NA NA NA hsa-let-7b-5p IGSF3 -0.959013717270803 5.95127281258643e-11 1.91695429086417 2.70260740063459e-11 miRNAWalker2_validate -0.189778473997686 0.0488457801136866 NA NA NA hsa-let-7b-5p IKBKAP -0.959013717270803 5.95127281258643e-11 0.197827394786134 0.0866747029294236 miRNATAP -0.103975472804855 0.00562144145578407 NA NA NA hsa-let-7a-5p IKBKE -0.328069937201898 0.000464344093744051 1.08048087739138 6.49410897517765e-06 TargetScan -0.254553233816602 0.0451300500978233 NA NA NA hsa-let-7a-5p ILKAP -0.328069937201898 0.000464344093744051 0.219997251339125 0.0032646363838474 miRNAWalker2_validate -0.126670228027157 0.00116095323005255 NA NA NA hsa-let-7b-5p IMPDH2 -0.959013717270803 5.95127281258643e-11 0.73431617900343 6.35213203227295e-10 miRNAWalker2_validate -0.266275048848206 4.7965371263893e-12 NA NA NA hsa-let-7b-5p INTS1 -0.959013717270803 5.95127281258643e-11 0.560773003303116 1.73987453576861e-11 miRNAWalker2_validate -0.152549052901987 2.43031045391357e-08 NA NA NA hsa-let-7b-5p IP6K1 -0.959013717270803 5.95127281258643e-11 0.889516693961123 4.04556190796781e-31 miRNAWalker2_validate -0.174958666038479 2.70133177948339e-11 NA NA NA hsa-let-7c-5p IP6K1 -1.70744661345097 2.87934212005942e-20 0.889516693961123 4.04556190796781e-31 miRNAWalker2_validate -0.136554103095589 1.44616222053653e-11 NA NA NA hsa-let-7b-5p IPO4 -0.959013717270803 5.95127281258643e-11 0.414061966136999 1.86121916661744e-05 miRNAWalker2_validate -0.134700576161727 1.90680759135469e-05 NA NA NA hsa-let-7a-5p IRGQ -0.328069937201898 0.000464344093744051 0.902560453855328 7.48220981072122e-23 TargetScan -0.232171158357789 3.68181712471845e-06 NA NA NA hsa-let-7b-5p ISOC2 -0.959013717270803 5.95127281258643e-11 -0.427372405723124 0.00119721926891207 miRNAWalker2_validate -0.115576367081947 0.00737348682091799 NA NA NA hsa-let-7d-5p KATNAL1 0.0503292020123807 0.702580311853671 -0.587180254929299 2.39212781667801e-05 miRNAWalker2_validate -0.113015792677892 0.0304319896475553 NA NA NA hsa-let-7a-5p KCMF1 -0.328069937201898 0.000464344093744051 0.204740867798868 8.9256981325294e-05 TargetScan -0.107254723739526 7.48568236574973e-05 NA NA NA hsa-let-7b-5p KCNC3 -0.959013717270803 5.95127281258643e-11 0.30337353022199 0.0786907238337105 mirMAP -0.124590251165422 0.0268718770179025 NA NA NA hsa-let-7a-5p KCTD17 -0.328069937201898 0.000464344093744051 0.903379904615084 0.000443017892119058 MirTarget;TargetScan;miRNATAP -0.316298414453377 0.0196861765101042 NA NA NA hsa-let-7c-5p KCTD17 -1.70744661345097 2.87934212005942e-20 0.903379904615084 0.000443017892119058 MirTarget -0.481480851735286 2.15992968805401e-14 NA NA NA hsa-let-7b-5p KDELR1 -0.959013717270803 5.95127281258643e-11 0.213082042643354 0.00499475480356304 miRNAWalker2_validate -0.113974115336439 3.15987260292689e-06 NA NA NA hsa-let-7b-5p KIAA1429 -0.959013717270803 5.95127281258643e-11 0.529087998279843 4.72515528254996e-10 miRNAWalker2_validate;MirTarget -0.138951810409148 6.16798657365767e-07 NA NA NA hsa-let-7c-5p KIAA1429 -1.70744661345097 2.87934212005942e-20 0.529087998279843 4.72515528254996e-10 MirTarget -0.12056072911504 1.72477615472835e-08 NA NA NA hsa-let-7b-5p KIFC1 -0.959013717270803 5.95127281258643e-11 3.81845068159089 7.73714657078986e-49 miRNAWalker2_validate -0.512018058822255 5.94513853960002e-08 NA NA NA hsa-let-7d-5p KLF9 0.0503292020123807 0.702580311853671 -1.35905833834713 1.22932810880238e-12 MirTarget;miRNATAP -0.242040769591897 0.000926153234185354 NA NA NA hsa-let-7a-5p KLHDC8B -0.328069937201898 0.000464344093744051 0.524333646266656 6.20608833052194e-05 MirTarget;TargetScan;miRNATAP -0.138989228541547 0.0444283372181136 NA NA NA hsa-let-7b-5p KLHDC8B -0.959013717270803 5.95127281258643e-11 0.524333646266656 6.20608833052194e-05 MirTarget;miRNATAP -0.144247411648415 0.000759795300462202 NA NA NA hsa-let-7d-5p KLHL13 0.0503292020123807 0.702580311853671 -0.261722831294332 0.243537926578299 MirTarget;miRNATAP -0.272139388924002 0.0010852887668577 NA NA NA hsa-let-7a-5p KLHL31 -0.328069937201898 0.000464344093744051 1.26597140369387 1.58519014245934e-11 MirTarget;TargetScan -0.200390560486202 0.047380228858103 NA NA NA hsa-let-7b-5p KLHL31 -0.959013717270803 5.95127281258643e-11 1.26597140369387 1.58519014245934e-11 MirTarget -0.40512692660528 4.23570589794434e-11 NA NA NA hsa-let-7c-5p KLHL31 -1.70744661345097 2.87934212005942e-20 1.26597140369387 1.58519014245934e-11 MirTarget -0.113451025803371 0.019099409616493 NA NA NA hsa-let-7b-5p LACTB2 -0.959013717270803 5.95127281258643e-11 -0.190481353407825 0.165558442155251 miRNAWalker2_validate -0.148711256809492 0.000852129804965774 NA NA NA hsa-let-7b-5p LARP1 -0.959013717270803 5.95127281258643e-11 0.631280547716208 2.42762598419254e-16 miRNAWalker2_validate -0.100984314325892 9.10480603745096e-05 NA NA NA hsa-let-7c-5p LBR -1.70744661345097 2.87934212005942e-20 0.388685096070557 0.000119421752361692 MirTarget -0.180026392917426 3.89595826197494e-13 NA NA NA hsa-let-7a-5p LHFPL2 -0.328069937201898 0.000464344093744051 0.0860745571518011 0.643643601257953 miRNAWalker2_validate -0.199008468682075 0.0411225907062279 NA NA NA hsa-let-7a-5p LIMD2 -0.328069937201898 0.000464344093744051 -0.214037676050721 0.282021903246009 MirTarget;TargetScan;miRNATAP -0.249707909998513 0.0165268795434474 NA NA NA hsa-let-7c-5p LIMD2 -1.70744661345097 2.87934212005942e-20 -0.214037676050721 0.282021903246009 MirTarget -0.218360777157729 1.04445562421957e-05 NA NA NA hsa-let-7c-5p LIMK2 -1.70744661345097 2.87934212005942e-20 0.891712220823075 3.4499668982677e-09 MirTarget -0.236593103071651 4.17089447540952e-10 NA NA NA hsa-let-7a-5p LIN28B -0.328069937201898 0.000464344093744051 2.26854994708754 4.69141976850235e-05 MirTarget;TargetScan;miRNATAP -2.11874012482628 1.35468790077563e-13 26071398 Mechanistically we discovered that Lin28B a well-characterized inhibitor of let-7 miRNA biogenesis was a direct target of miR-125a-5p in melanoma melanoma hsa-let-7b-5p LIN28B -0.959013717270803 5.95127281258643e-11 2.26854994708754 4.69141976850235e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -1.87019493947882 1.23019993084973e-27 26609473;26071398 LIN28B suppresses microRNA let 7b expression to promote CD44+/LIN28B+ human pancreatic cancer stem cell proliferation and invasion;Mechanistically we discovered that Lin28B a well-characterized inhibitor of let-7 miRNA biogenesis was a direct target of miR-125a-5p in melanoma ; pancreatic cancer;melanoma hsa-let-7c-5p LIN28B -1.70744661345097 2.87934212005942e-20 2.26854994708754 4.69141976850235e-05 MirTarget -0.942677952234562 8.19224435516587e-12 NA NA NA hsa-let-7d-5p LIN28B 0.0503292020123807 0.702580311853671 2.26854994708754 4.69141976850235e-05 miRNAWalker2_validate;MirTarget;miRNATAP -2.27935905042896 6.58353917461463e-32 NA NA NA hsa-let-7a-5p LIPT2 -0.328069937201898 0.000464344093744051 -0.0121397937515861 0.921611183822164 MirTarget;TargetScan;miRNATAP -0.151199507734122 0.0189948648135521 NA NA NA hsa-let-7b-5p LIPT2 -0.959013717270803 5.95127281258643e-11 -0.0121397937515861 0.921611183822164 MirTarget;miRNATAP -0.124640615111026 0.00183827369087978 NA NA NA hsa-let-7b-5p LLPH -0.959013717270803 5.95127281258643e-11 0.216128578559967 0.00083576925199987 miRNAWalker2_validate -0.102878614272622 7.59883720211006e-07 NA NA NA hsa-let-7b-5p LMAN2 -0.959013717270803 5.95127281258643e-11 0.408208872972229 3.08893439678783e-05 miRNAWalker2_validate -0.187395048603059 2.94232323571638e-09 NA NA NA hsa-let-7a-5p LMNA -0.328069937201898 0.000464344093744051 0.872738114417365 9.96436798966192e-17 miRNAWalker2_validate -0.155968132825577 0.00628422881471586 20535543 Twenty-five differentially expressed miRNAs P < 0.01 were identified of which let-7 family miRNAs were down-regulated in human breast cancer tissues at stages of DCIS and IDC compared to benign stage staging breast cancer hsa-let-7b-5p LPL -0.959013717270803 5.95127281258643e-11 2.28010324035066 5.5045312934226e-24 miRNAWalker2_validate -0.234847069254168 0.00256757213375238 NA NA NA hsa-let-7a-5p LRPAP1 -0.328069937201898 0.000464344093744051 0.106274117890811 0.220665994568318 mirMAP -0.134121273772391 0.00298851150946296 NA NA NA hsa-let-7d-5p LRRC42 0.0503292020123807 0.702580311853671 0.444671434214161 5.03218028399188e-06 miRNAWalker2_validate -0.105109145561902 0.00400217369559121 NA NA NA hsa-let-7a-5p LRRC59 -0.328069937201898 0.000464344093744051 0.441548574766935 5.64199580946937e-09 TargetScan -0.143880471498239 0.000329342818298737 NA NA NA hsa-let-7b-5p LSM11 -0.959013717270803 5.95127281258643e-11 0.758646663868328 2.93737544855881e-13 miRNATAP -0.134780427140456 0.000100576317100993 NA NA NA hsa-let-7a-5p LTA4H -0.328069937201898 0.000464344093744051 0.114916227161483 0.0936209496255586 miRNAWalker2_validate -0.117338241837862 0.000967867053811254 NA NA NA hsa-let-7a-5p LZIC -0.328069937201898 0.000464344093744051 0.126530628815074 0.205817880943251 TargetScan -0.108454294397606 0.0380243239782376 NA NA NA hsa-let-7b-5p LZIC -0.959013717270803 5.95127281258643e-11 0.126530628815074 0.205817880943251 miRNAWalker2_validate -0.128863151414494 6.63836892965126e-05 NA NA NA hsa-let-7b-5p MAP2K2 -0.959013717270803 5.95127281258643e-11 0.626002935787801 2.22116323165311e-10 miRNAWalker2_validate -0.179048006528372 3.03569472992354e-08 NA NA NA hsa-let-7b-5p MARS -0.959013717270803 5.95127281258643e-11 0.64452491611577 5.35795642860953e-17 miRNAWalker2_validate -0.149236695612828 5.11275558167241e-09 NA NA NA hsa-let-7b-5p MCM4 -0.959013717270803 5.95127281258643e-11 1.32614408881812 5.23855543390612e-15 miRNAWalker2_validate -0.127824287587723 0.025555024739509 NA NA NA hsa-let-7b-5p MCM7 -0.959013717270803 5.95127281258643e-11 1.28544451959494 2.38346141988918e-22 miRNAWalker2_validate -0.247616423212068 3.20929332495545e-08 NA NA NA hsa-let-7c-5p MDFI -1.70744661345097 2.87934212005942e-20 1.613063811487 1.62996375672374e-07 MirTarget -0.449944709746608 5.78696252416618e-09 NA NA NA hsa-let-7c-5p MDM4 -1.70744661345097 2.87934212005942e-20 0.73357660128009 1.75853291398166e-12 MirTarget -0.16378523997819 4.65469630843185e-10 NA NA NA hsa-let-7a-5p MED6 -0.328069937201898 0.000464344093744051 0.127858256616097 0.062607194517538 TargetScan;miRNATAP -0.100644282072337 0.00481969210153239 NA NA NA hsa-let-7a-5p MED8 -0.328069937201898 0.000464344093744051 0.180596254828574 0.0158088706299798 TargetScan;miRNATAP -0.230283177049535 1.95014548636227e-09 NA NA NA hsa-let-7b-5p MED8 -0.959013717270803 5.95127281258643e-11 0.180596254828574 0.0158088706299798 miRNATAP -0.180335781003419 1.94412973409361e-14 NA NA NA hsa-let-7d-5p MED8 0.0503292020123807 0.702580311853671 0.180596254828574 0.0158088706299798 miRNATAP -0.141497128539281 2.46288341232295e-07 NA NA NA hsa-let-7a-5p METTL6 -0.328069937201898 0.000464344093744051 0.821817118358683 2.12474548257229e-31 miRNAWalker2_validate -0.102072275741626 0.0100959548680202 NA NA NA hsa-let-7b-5p MFSD3 -0.959013717270803 5.95127281258643e-11 0.471150411354968 0.00427305406525264 miRNAWalker2_validate -0.217453673579495 4.94297984581802e-05 NA NA NA hsa-let-7c-5p MGAT4A -1.70744661345097 2.87934212005942e-20 0.104155687943847 0.347191347682603 MirTarget -0.139105957783091 3.9224788202799e-07 NA NA NA hsa-let-7b-5p MKRN2 -0.959013717270803 5.95127281258643e-11 0.246110956654915 0.000277735100386935 miRNAWalker2_validate -0.120576774604095 2.88176503426264e-08 NA NA NA hsa-let-7b-5p MOV10 -0.959013717270803 5.95127281258643e-11 0.26470200400998 0.00189960631046037 miRNAWalker2_validate -0.150421667673522 3.99587972465441e-08 NA NA NA hsa-let-7b-5p MPG -0.959013717270803 5.95127281258643e-11 -0.206511991841908 0.0504738281019207 miRNAWalker2_validate -0.147319770353927 1.56564658469546e-05 NA NA NA hsa-let-7d-5p MPL 0.0503292020123807 0.702580311853671 -0.248715300490881 0.101984451680396 miRNAWalker2_validate -0.204136525483039 0.000292050444479849 NA NA NA hsa-let-7b-5p MPND -0.959013717270803 5.95127281258643e-11 -0.0779793626892875 0.539884741504386 miRNAWalker2_validate -0.105456718901456 0.010765717611328 NA NA NA hsa-let-7b-5p MRM1 -0.959013717270803 5.95127281258643e-11 0.624230444091036 7.10795782609113e-09 miRNAWalker2_validate -0.258584232976057 9.19073168474872e-14 NA NA NA hsa-let-7a-5p MRPL15 -0.328069937201898 0.000464344093744051 0.174644060708377 0.0898719416318028 miRNAWalker2_validate -0.207546476413475 0.00010570904051621 NA NA NA hsa-let-7b-5p MRPL47 -0.959013717270803 5.95127281258643e-11 0.319461366645249 0.000493795346266864 miRNAWalker2_validate -0.139575689008518 2.55654855069706e-06 NA NA NA hsa-let-7d-5p MRPL51 0.0503292020123807 0.702580311853671 0.231114466985328 0.0179417571996883 miRNAWalker2_validate -0.175128964948038 1.09586645451703e-06 NA NA NA hsa-let-7b-5p MRPS11 -0.959013717270803 5.95127281258643e-11 0.139879903645642 0.123203126250254 miRNAWalker2_validate -0.150837447671953 2.20319466521088e-07 NA NA NA hsa-let-7a-5p MRPS2 -0.328069937201898 0.000464344093744051 -0.423956928487383 2.55163027000828e-05 miRNAWalker2_validate -0.165955863165623 0.0017317546209067 NA NA NA hsa-let-7b-5p MRPS24 -0.959013717270803 5.95127281258643e-11 0.0469965273502435 0.655193995865864 miRNAWalker2_validate -0.20079938630655 2.23537408113639e-09 NA NA NA hsa-let-7b-5p MRPS33 -0.959013717270803 5.95127281258643e-11 0.0790330591567772 0.419003085804975 miRNAWalker2_validate -0.175694900469772 1.93132624394747e-08 NA NA NA hsa-let-7a-5p MYCBP -0.328069937201898 0.000464344093744051 0.270320437141615 0.00287712114096272 TargetScan -0.160893684004434 0.000682550859989251 NA NA NA hsa-let-7b-5p NAA10 -0.959013717270803 5.95127281258643e-11 0.779001264513763 7.34967723961076e-12 miRNAWalker2_validate -0.213606872139424 1.11317096141578e-08 NA NA NA hsa-let-7a-5p NAA20 -0.328069937201898 0.000464344093744051 0.599647393043588 6.04293137448711e-11 TargetScan -0.174887066002787 0.000340155956757792 NA NA NA hsa-let-7b-5p NAA20 -0.959013717270803 5.95127281258643e-11 0.599647393043588 6.04293137448711e-11 miRNAWalker2_validate -0.158218512203524 1.48288382013101e-07 NA NA NA hsa-let-7b-5p NACA -0.959013717270803 5.95127281258643e-11 0.302207449000838 0.000129041363578753 miRNAWalker2_validate -0.190109111424388 2.96465263885179e-14 NA NA NA hsa-let-7a-5p NAP1L1 -0.328069937201898 0.000464344093744051 0.48873822323481 4.44413744556636e-06 MirTarget;TargetScan;miRNATAP -0.298977603986413 7.2327184027146e-08 NA NA NA hsa-let-7b-5p NAP1L1 -0.959013717270803 5.95127281258643e-11 0.48873822323481 4.44413744556636e-06 MirTarget;miRNATAP -0.171744131698511 7.10979592554345e-07 NA NA NA hsa-let-7c-5p NAP1L1 -1.70744661345097 2.87934212005942e-20 0.48873822323481 4.44413744556636e-06 MirTarget -0.248793874030014 2.70783118256391e-22 NA NA NA hsa-let-7a-5p NAT8L -0.328069937201898 0.000464344093744051 1.21195978404762 0.000153977148692105 TargetScan -0.552508559370608 0.00104800796880354 NA NA NA hsa-let-7b-5p NCAPD2 -0.959013717270803 5.95127281258643e-11 1.38066487291506 4.90709527116357e-23 miRNAWalker2_validate -0.189088419183812 7.73098246262242e-05 NA NA NA hsa-let-7b-5p NCAPG2 -0.959013717270803 5.95127281258643e-11 1.18935726047268 3.00796303010884e-16 miRNAWalker2_validate -0.11715467749962 0.0173714293288959 NA NA NA hsa-let-7b-5p NDRG1 -0.959013717270803 5.95127281258643e-11 0.654480193132553 0.000503878236136277 miRNAWalker2_validate -0.14640309208603 0.0176474805171348 NA NA NA hsa-let-7a-5p NDUFAF3 -0.328069937201898 0.000464344093744051 0.157897191477907 0.0921622320230597 miRNAWalker2_validate -0.204625165226062 2.57652555699549e-05 NA NA NA hsa-let-7b-5p NEDD4L -0.959013717270803 5.95127281258643e-11 0.864887679249782 8.63340597856756e-11 miRNATAP -0.116950336086552 0.00845520795088481 NA NA NA hsa-let-7a-5p NKAP -0.328069937201898 0.000464344093744051 0.502691283553284 1.41782808508399e-09 TargetScan -0.194810825452302 8.86879082237769e-06 NA NA NA hsa-let-7a-5p NKIRAS2 -0.328069937201898 0.000464344093744051 0.498667168432674 1.95803169770802e-13 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.115324999449337 0.00148853839013642 NA NA NA hsa-let-7b-5p NKIRAS2 -0.959013717270803 5.95127281258643e-11 0.498667168432674 1.95803169770802e-13 miRNATAP -0.187857831449357 5.65755919655962e-18 NA NA NA hsa-let-7b-5p NLE1 -0.959013717270803 5.95127281258643e-11 0.691175093309583 4.19043198742371e-09 miRNAWalker2_validate -0.316066804906547 3.84391574034598e-17 NA NA NA hsa-let-7a-5p NME4 -0.328069937201898 0.000464344093744051 -0.192079618663637 0.164462252316285 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.260742256384965 0.000292030671884371 NA NA NA hsa-let-7a-5p NME6 -0.328069937201898 0.000464344093744051 0.606950484577572 4.34851975188018e-13 MirTarget;TargetScan;miRNATAP -0.315162958795598 6.38618806869435e-13 NA NA NA hsa-let-7b-5p NME6 -0.959013717270803 5.95127281258643e-11 0.606950484577572 4.34851975188018e-13 miRNAWalker2_validate;MirTarget;miRNATAP -0.264571241648409 1.93793537087046e-23 NA NA NA hsa-let-7c-5p NME6 -1.70744661345097 2.87934212005942e-20 0.606950484577572 4.34851975188018e-13 MirTarget -0.214598920327561 3.81766152781017e-26 NA NA NA hsa-let-7d-5p NME6 0.0503292020123807 0.702580311853671 0.606950484577572 4.34851975188018e-13 MirTarget;miRNATAP -0.103988301459166 0.00111909871404482 NA NA NA hsa-let-7b-5p NOMO3 -0.959013717270803 5.95127281258643e-11 0.467587107825511 2.07803072269442e-05 miRNAWalker2_validate -0.107770478723849 0.00276455525120706 NA NA NA hsa-let-7a-5p NPEPL1 -0.328069937201898 0.000464344093744051 1.0134980247578 2.1959859851927e-21 TargetScan -0.240844749343578 3.68381484689572e-05 NA NA NA hsa-let-7c-5p NPTX1 -1.70744661345097 2.87934212005942e-20 0.929025880461533 0.00584289763512414 miRNAWalker2_validate -0.349636575478964 3.44078587361936e-05 NA NA NA hsa-let-7c-5p NRARP -1.70744661345097 2.87934212005942e-20 0.806873954048561 5.97890763868229e-07 MirTarget -0.111854005713575 0.00649160992703926 NA NA NA hsa-let-7b-5p NRAS -0.959013717270803 5.95127281258643e-11 0.301156333096785 0.000285671613438218 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.105903409272711 8.57245668973746e-05 20607356 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells glioblastoma hsa-let-7b-5p NSA2 -0.959013717270803 5.95127281258643e-11 0.152301499675499 0.0762962568480935 miRNAWalker2_validate -0.206080425981389 2.62348791224119e-14 NA NA NA hsa-let-7a-5p NSMCE2 -0.328069937201898 0.000464344093744051 1.35276784720421 1.07528528176512e-24 TargetScan -0.35184105839395 1.226654807338e-06 NA NA NA hsa-let-7b-5p NSMCE4A -0.959013717270803 5.95127281258643e-11 -0.0493886377180992 0.537115377656929 miRNAWalker2_validate -0.112484409569361 1.22851318923437e-05 NA NA NA hsa-let-7b-5p NT5DC2 -0.959013717270803 5.95127281258643e-11 2.16871503598175 2.70972887150847e-20 miRNAWalker2_validate -0.193857297207221 0.0159655373805673 NA NA NA hsa-let-7b-5p NUBP2 -0.959013717270803 5.95127281258643e-11 0.02837616055354 0.751795428939655 miRNAWalker2_validate -0.154605361021248 7.19521906280206e-08 NA NA NA hsa-let-7b-5p NUDT19 -0.959013717270803 5.95127281258643e-11 -0.0179115076399192 0.895228240317122 miRNAWalker2_validate -0.112587149189431 0.010887658495243 NA NA NA hsa-let-7a-5p NUDT5 -0.328069937201898 0.000464344093744051 0.242121832773312 0.0107247490806487 miRNAWalker2_validate -0.130398500281109 0.00863013618718244 NA NA NA hsa-let-7b-5p NUSAP1 -0.959013717270803 5.95127281258643e-11 2.13379528300653 8.33883903420606e-30 miRNAWalker2_validate -0.262396363247835 6.37559475921183e-05 NA NA NA hsa-let-7b-5p NVL -0.959013717270803 5.95127281258643e-11 1.07132153567091 3.79439194026463e-34 miRNAWalker2_validate -0.160828248927949 1.62113892866165e-07 NA NA NA hsa-let-7b-5p ONECUT2 -0.959013717270803 5.95127281258643e-11 0.120890541524141 0.551384233388767 miRNATAP -0.236879156030054 0.000318723815362081 NA NA NA hsa-let-7d-5p ONECUT2 0.0503292020123807 0.702580311853671 0.120890541524141 0.551384233388767 miRNAWalker2_validate;miRNATAP -0.266999748917132 0.000382460965461143 NA NA NA hsa-let-7a-5p OPA3 -0.328069937201898 0.000464344093744051 0.291125258853402 0.000184092538128601 mirMAP -0.181344007655875 7.59042728393218e-06 NA NA NA hsa-let-7b-5p OPA3 -0.959013717270803 5.95127281258643e-11 0.291125258853402 0.000184092538128601 mirMAP -0.103992565249277 3.82664311255807e-05 NA NA NA hsa-let-7a-5p ORAI2 -0.328069937201898 0.000464344093744051 0.147939436354318 0.336648923993268 miRNAWalker2_validate -0.224131605717642 0.00534200008184397 NA NA NA hsa-let-7a-5p OSBPL3 -0.328069937201898 0.000464344093744051 1.89349683919437 1.36278729360079e-25 TargetScan;miRNATAP -0.224443129449789 0.0263225208512254 NA NA NA hsa-let-7b-5p OTUB1 -0.959013717270803 5.95127281258643e-11 0.25138819190632 0.000439411668726384 miRNAWalker2_validate -0.123469901131303 7.84226905940981e-08 NA NA NA hsa-let-7b-5p OXA1L -0.959013717270803 5.95127281258643e-11 0.297650216542934 3.08931019692821e-05 miRNAWalker2_validate -0.167744527603903 1.41543583639881e-13 NA NA NA hsa-let-7a-5p P4HA2 -0.328069937201898 0.000464344093744051 1.28443986350754 2.47987914950334e-16 TargetScan;miRNATAP -0.348495808263774 3.87857147374423e-05 NA NA NA hsa-let-7b-5p P4HA2 -0.959013717270803 5.95127281258643e-11 1.28443986350754 2.47987914950334e-16 miRNATAP -0.23110994283278 1.12742721157976e-05 NA NA NA hsa-let-7b-5p PA2G4 -0.959013717270803 5.95127281258643e-11 0.453574716540413 2.81160688733313e-09 miRNAWalker2_validate -0.196998242006096 6.28590420940879e-16 NA NA NA hsa-let-7b-5p PAAF1 -0.959013717270803 5.95127281258643e-11 0.0873646216607753 0.288865981039092 miRNAWalker2_validate -0.137338943917943 1.918982136684e-07 NA NA NA hsa-let-7b-5p PABPC1 -0.959013717270803 5.95127281258643e-11 0.734137538715334 7.38475099842446e-08 miRNAWalker2_validate -0.224438843172547 4.89578258922415e-07 NA NA NA hsa-let-7b-5p PAFAH1B3 -0.959013717270803 5.95127281258643e-11 1.45698304510611 9.85210329399848e-12 miRNAWalker2_validate -0.241676377019908 0.000709424808974363 NA NA NA hsa-let-7c-5p PAG1 -1.70744661345097 2.87934212005942e-20 -0.0641776217701535 0.737132600565642 MirTarget -0.11049170694399 0.0212818061791696 NA NA NA hsa-let-7c-5p PAK4 -1.70744661345097 2.87934212005942e-20 0.332066945941027 0.000554855795687645 miRNAWalker2_validate -0.146202847790971 7.66415471826461e-10 NA NA NA hsa-let-7d-5p PALM3 0.0503292020123807 0.702580311853671 -1.58382708788167 8.9027632018976e-08 miRNATAP -0.278998468649916 0.0127682098398281 NA NA NA hsa-let-7c-5p PARD6B -1.70744661345097 2.87934212005942e-20 -0.0933903062942685 0.430333811242109 MirTarget -0.142218447562304 1.26822558335396e-06 NA NA NA hsa-let-7a-5p PARS2 -0.328069937201898 0.000464344093744051 0.348894373574521 6.92206820264045e-05 MirTarget -0.164572277127589 0.000340534283942615 NA NA NA hsa-let-7b-5p PARS2 -0.959013717270803 5.95127281258643e-11 0.348894373574521 6.92206820264045e-05 MirTarget -0.181280180404567 1.11359732740136e-10 NA NA NA hsa-let-7d-5p PARS2 0.0503292020123807 0.702580311853671 0.348894373574521 6.92206820264045e-05 MirTarget -0.176592129417323 4.6531310626769e-08 NA NA NA hsa-let-7b-5p PBX2 -0.959013717270803 5.95127281258643e-11 0.498538962015405 1.29077445670686e-07 miRNATAP -0.120114685392743 0.000105891416975019 NA NA NA hsa-let-7b-5p PCBP4 -0.959013717270803 5.95127281258643e-11 1.08551361354041 1.48859990502195e-18 miRNATAP -0.208360216125972 5.26390859850764e-07 NA NA NA hsa-let-7c-5p PCGF3 -1.70744661345097 2.87934212005942e-20 0.167536921370584 0.0398744101142924 miRNAWalker2_validate;MirTarget -0.113853768613945 1.4497220623856e-08 NA NA NA hsa-let-7b-5p PCYT2 -0.959013717270803 5.95127281258643e-11 0.00446147360920346 0.974419085805155 miRNAWalker2_validate -0.260927523407124 4.49138484187668e-09 NA NA NA hsa-let-7b-5p PDCD11 -0.959013717270803 5.95127281258643e-11 0.494428811191069 4.69394869205167e-09 miRNAWalker2_validate -0.140366849645389 3.6540184423377e-07 NA NA NA hsa-let-7b-5p PDK1 -0.959013717270803 5.95127281258643e-11 0.128202183204631 0.393350859302971 miRNAWalker2_validate -0.175514081154918 0.000311312050748879 NA NA NA hsa-let-7d-5p PDP2 0.0503292020123807 0.702580311853671 -0.449946555806165 0.00178954078552096 MirTarget -0.24011561684853 6.83510609919972e-06 NA NA NA hsa-let-7b-5p PEX6 -0.959013717270803 5.95127281258643e-11 0.416007630554884 0.00125536321021315 miRNAWalker2_validate -0.220720362210586 1.1489510010811e-07 NA NA NA hsa-let-7d-5p PGRMC1 0.0503292020123807 0.702580311853671 -0.899011937853434 4.01593880771907e-09 MirTarget;miRNATAP -0.197051332788424 0.000645523581557055 NA NA NA hsa-let-7a-5p PIGU -0.328069937201898 0.000464344093744051 1.07163808512416 1.69286736457416e-25 TargetScan -0.341044708443863 1.19011250521773e-09 NA NA NA hsa-let-7b-5p PIGU -0.959013717270803 5.95127281258643e-11 1.07163808512416 1.69286736457416e-25 miRNAWalker2_validate -0.242541787221653 2.56134006149652e-12 NA NA NA hsa-let-7b-5p PIH1D1 -0.959013717270803 5.95127281258643e-11 0.290391379575548 0.00279648938766356 miRNAWalker2_validate -0.150680243847219 1.56857971298947e-06 NA NA NA hsa-let-7a-5p PLA2G15 -0.328069937201898 0.000464344093744051 -0.0177636894337114 0.862078942273828 MirTarget;TargetScan;miRNATAP -0.17792333125268 0.000821825568199362 NA NA NA hsa-let-7d-5p PLA2G15 0.0503292020123807 0.702580311853671 -0.0177636894337114 0.862078942273828 MirTarget;miRNATAP -0.115796600646005 0.00221114425306108 NA NA NA hsa-let-7c-5p PLAGL2 -1.70744661345097 2.87934212005942e-20 0.336986331692996 0.00300478705110513 MirTarget -0.167081915992385 2.69511671900005e-09 NA NA NA hsa-let-7a-5p PLEKHA8 -0.328069937201898 0.000464344093744051 0.853850470406739 4.18817555590069e-10 TargetScan -0.151300512772583 0.0386944578567522 NA NA NA hsa-let-7c-5p PLEKHG6 -1.70744661345097 2.87934212005942e-20 0.0255008978984725 0.925472142399852 MirTarget -0.203069992909591 0.0029441217881029 NA NA NA hsa-let-7a-5p PLEKHH1 -0.328069937201898 0.000464344093744051 1.25039195218202 7.83074573807631e-12 TargetScan;miRNATAP -0.310877421184404 0.00152063652150149 NA NA NA hsa-let-7b-5p PLEKHH1 -0.959013717270803 5.95127281258643e-11 1.25039195218202 7.83074573807631e-12 miRNATAP -0.223820469322397 0.000236814355464294 NA NA NA hsa-let-7a-5p PLEKHO1 -0.328069937201898 0.000464344093744051 0.0444881047969297 0.77538290639675 TargetScan;miRNATAP -0.303866493453079 0.000180072212540554 NA NA NA hsa-let-7b-5p PLK1 -0.959013717270803 5.95127281258643e-11 3.58200503456178 1.01936996392609e-41 miRNAWalker2_validate -0.508374715415364 7.45675351637923e-08 NA NA NA hsa-let-7a-5p PLOD1 -0.328069937201898 0.000464344093744051 0.183475365938223 0.101859018616887 miRNAWalker2_validate -0.191646319875312 0.0010490924804916 NA NA NA hsa-let-7c-5p PLXND1 -1.70744661345097 2.87934212005942e-20 0.69765536803745 4.01395417482674e-09 MirTarget -0.121343527002517 5.62640054248759e-05 NA NA NA hsa-let-7b-5p PMF1 -0.959013717270803 5.95127281258643e-11 0.636539964999771 3.08425126175709e-09 miRNAWalker2_validate -0.163388359538845 3.6651270462549e-06 NA NA NA hsa-let-7b-5p POLD2 -0.959013717270803 5.95127281258643e-11 -0.0956910482206927 0.351453134850314 miRNAWalker2_validate -0.124926174858705 0.000167953905984256 NA NA NA hsa-let-7a-5p POLL -0.328069937201898 0.000464344093744051 0.328578290158898 7.5429233323312e-05 MirTarget -0.202859691742012 2.6871635921386e-06 NA NA NA hsa-let-7b-5p POLL -0.959013717270803 5.95127281258643e-11 0.328578290158898 7.5429233323312e-05 MirTarget -0.196744454221768 8.52309108125034e-14 NA NA NA hsa-let-7b-5p POLR1A -0.959013717270803 5.95127281258643e-11 0.685972895492656 7.69671870321328e-11 miRNAWalker2_validate -0.12696328299634 0.000281834241057279 NA NA NA hsa-let-7b-5p POLR2C -0.959013717270803 5.95127281258643e-11 -0.0729598636215139 0.428774430905846 miRNAWalker2_validate -0.141386470430439 1.81840767848556e-06 NA NA NA hsa-let-7a-5p POLR2D -0.328069937201898 0.000464344093744051 0.275095172496949 0.00010771626085233 TargetScan -0.143553274715388 0.000107133351698008 NA NA NA hsa-let-7b-5p POLR2H -0.959013717270803 5.95127281258643e-11 0.426274017091971 9.20500795387622e-06 miRNAWalker2_validate -0.185989238576208 1.98397715389055e-09 NA NA NA hsa-let-7b-5p POLR2L -0.959013717270803 5.95127281258643e-11 0.331789461260779 0.00516152086751448 miRNAWalker2_validate -0.203697183893833 9.8432064077088e-08 NA NA NA hsa-let-7b-5p POLR3G -0.959013717270803 5.95127281258643e-11 0.307542967529863 0.0325255410432537 miRNAWalker2_validate -0.236443555090476 3.39441856846e-07 NA NA NA hsa-let-7b-5p PPM1G -0.959013717270803 5.95127281258643e-11 0.574348560632392 2.1822247920007e-15 miRNAWalker2_validate -0.165175367521945 3.32518919814017e-12 NA NA NA hsa-let-7b-5p PPP1R7 -0.959013717270803 5.95127281258643e-11 0.107841453806328 0.166249227022564 miRNAWalker2_validate -0.108934004617421 1.38229603292823e-05 NA NA NA hsa-let-7a-5p PQLC2 -0.328069937201898 0.000464344093744051 0.410624419569461 0.000127151881761711 TargetScan -0.282484896221789 4.07238686311079e-07 NA NA NA hsa-let-7c-5p PRAF2 -1.70744661345097 2.87934212005942e-20 0.470949457085433 4.21533714109916e-05 miRNAWalker2_validate -0.114609565008073 7.36690639861184e-05 NA NA NA hsa-let-7a-5p PREB -0.328069937201898 0.000464344093744051 0.451967819252287 4.74546293024549e-05 miRNAWalker2_validate -0.121575037855604 0.0381534346299493 NA NA NA hsa-let-7b-5p PRIM1 -0.959013717270803 5.95127281258643e-11 1.30250431119332 1.7051401321804e-14 miRNAWalker2_validate -0.303357872305665 7.6487451406738e-08 NA NA NA hsa-let-7b-5p PRKAA2 -0.959013717270803 5.95127281258643e-11 0.910177606708893 0.0133266185680845 miRNAWalker2_validate;MirTarget -0.399590032732691 0.000857606952583238 NA NA NA hsa-let-7c-5p PRKAA2 -1.70744661345097 2.87934212005942e-20 0.910177606708893 0.0133266185680845 MirTarget -0.323478962357034 0.000457014156060023 NA NA NA hsa-let-7b-5p PRPF19 -0.959013717270803 5.95127281258643e-11 0.118858095385951 0.0594696560786151 miRNAWalker2_validate -0.110331095303137 4.08845061152587e-08 NA NA NA hsa-let-7d-5p PRR13 0.0503292020123807 0.702580311853671 -0.0415709762097505 0.610932494320088 miRNAWalker2_validate -0.103494632342427 0.000594476254263453 NA NA NA hsa-let-7c-5p PRRX1 -1.70744661345097 2.87934212005942e-20 2.13747637731194 2.98162416691034e-16 MirTarget -0.352682612593982 1.66283334492681e-07 NA NA NA hsa-let-7a-5p PSMA2 -0.328069937201898 0.000464344093744051 -0.390800012363166 9.5449730317426e-07 miRNAWalker2_validate -0.10265187669004 0.0147920136402055 NA NA NA hsa-let-7b-5p PSMD9 -0.959013717270803 5.95127281258643e-11 0.178529208564949 0.0221595623480635 miRNAWalker2_validate -0.150267448147477 1.58505777774568e-09 NA NA NA hsa-let-7b-5p PSMG4 -0.959013717270803 5.95127281258643e-11 0.341033466263636 0.0060889740816588 miRNAWalker2_validate -0.304937878058034 8.74548274206421e-15 NA NA NA hsa-let-7b-5p PTCD1 -0.959013717270803 5.95127281258643e-11 0.715450238881582 9.02838097730402e-16 miRNAWalker2_validate -0.139623817457307 2.59687697152815e-06 NA NA NA hsa-let-7a-5p PTGES2 -0.328069937201898 0.000464344093744051 0.505915263560095 4.3460926132534e-06 miRNAWalker2_validate -0.28020260410249 1.14988546946586e-06 NA NA NA hsa-let-7b-5p PTGES2 -0.959013717270803 5.95127281258643e-11 0.505915263560095 4.3460926132534e-06 miRNAWalker2_validate -0.192053071170217 7.68873636029694e-08 NA NA NA hsa-let-7c-5p PTGES2 -1.70744661345097 2.87934212005942e-20 0.505915263560095 4.3460926132534e-06 miRNAWalker2_validate -0.150018737330616 5.00669169745312e-08 NA NA NA hsa-let-7c-5p PTK2 -1.70744661345097 2.87934212005942e-20 0.592116034898139 1.42360483588582e-09 miRNAWalker2_validate -0.111526582483996 6.85487252665759e-06 NA NA NA hsa-let-7b-5p PTPN23 -0.959013717270803 5.95127281258643e-11 0.508871154683548 3.79212672893496e-13 miRNAWalker2_validate -0.136016200003431 3.25699631288952e-09 NA NA NA hsa-let-7b-5p PTTG1 -0.959013717270803 5.95127281258643e-11 3.76246853388833 8.36103372767795e-44 miRNAWalker2_validate -0.651597525972495 1.331355553891e-11 NA NA NA hsa-let-7b-5p PUS1 -0.959013717270803 5.95127281258643e-11 0.613692717301236 1.61417682455694e-08 miRNAWalker2_validate -0.246147799177445 2.18231401443713e-12 NA NA NA hsa-let-7a-5p PXMP4 -0.328069937201898 0.000464344093744051 0.626458258235179 3.75424767991764e-08 TargetScan -0.168656499175782 0.0052843517236011 NA NA NA hsa-let-7b-5p PYCRL -0.959013717270803 5.95127281258643e-11 0.830809890342951 7.37352070902481e-10 miRNAWalker2_validate -0.264268347344177 2.03282544419536e-09 NA NA NA hsa-let-7b-5p PYGO2 -0.959013717270803 5.95127281258643e-11 1.17890176614 2.86682262433208e-35 miRNATAP -0.14999758878488 7.45337601775916e-06 NA NA NA hsa-let-7a-5p QARS -0.328069937201898 0.000464344093744051 0.594342167610161 2.31140713137187e-12 TargetScan;miRNATAP -0.221557459438795 8.31654291585892e-07 NA NA NA hsa-let-7b-5p QARS -0.959013717270803 5.95127281258643e-11 0.594342167610161 2.31140713137187e-12 miRNAWalker2_validate;miRNATAP -0.227269832286066 7.23890989134896e-17 NA NA NA hsa-let-7b-5p RAB11FIP4 -0.959013717270803 5.95127281258643e-11 1.54437373311846 7.02562100479325e-17 MirTarget;miRNATAP -0.192667518030403 0.00209338637077878 NA NA NA hsa-let-7c-5p RAB11FIP4 -1.70744661345097 2.87934212005942e-20 1.54437373311846 7.02562100479325e-17 MirTarget -0.366743712732836 4.57221998622098e-15 NA NA NA hsa-let-7a-5p RAB13 -0.328069937201898 0.000464344093744051 0.212904537096809 0.017073886946895 miRNAWalker2_validate -0.108626205692339 0.020011021953545 NA NA NA hsa-let-7a-5p RAB15 -0.328069937201898 0.000464344093744051 0.191761348491017 0.18349645899402 TargetScan;miRNATAP -0.257236227353884 0.000622750251923055 NA NA NA hsa-let-7b-5p RAB15 -0.959013717270803 5.95127281258643e-11 0.191761348491017 0.18349645899402 miRNATAP -0.150865820157622 0.00127200526470108 NA NA NA hsa-let-7c-5p RAB34 -1.70744661345097 2.87934212005942e-20 0.412870987704762 0.126202873299987 miRNAWalker2_validate -0.284015184457008 2.48793947860605e-05 NA NA NA hsa-let-7d-5p RAB40C 0.0503292020123807 0.702580311853671 0.0777915162155001 0.33094698207606 miRNATAP -0.101584449072569 0.000577895089538376 NA NA NA hsa-let-7b-5p RAD18 -0.959013717270803 5.95127281258643e-11 0.734804507433037 1.25694117049507e-15 MirTarget -0.143300678052544 2.96624646779998e-06 NA NA NA hsa-let-7c-5p RAD18 -1.70744661345097 2.87934212005942e-20 0.734804507433037 1.25694117049507e-15 MirTarget -0.162229147179546 3.03633151346655e-12 NA NA NA hsa-let-7c-5p RAPGEFL1 -1.70744661345097 2.87934212005942e-20 0.512757940233236 0.00610377319567469 miRNAWalker2_validate -0.104672283482989 0.0263816556863234 NA NA NA hsa-let-7b-5p RBM19 -0.959013717270803 5.95127281258643e-11 0.567812787873666 2.78250556869349e-16 miRNAWalker2_validate -0.191960850278849 1.19821801142791e-17 NA NA NA hsa-let-7b-5p RBM34 -0.959013717270803 5.95127281258643e-11 0.8422803261746 3.85063671504782e-19 miRNAWalker2_validate -0.205442236531017 5.64649009282546e-11 NA NA NA hsa-let-7a-5p RCN1 -0.328069937201898 0.000464344093744051 -0.291952116719679 0.0727379862149077 TargetScan -0.351045385639186 3.38218832418762e-05 NA NA NA hsa-let-7b-5p REEP4 -0.959013717270803 5.95127281258643e-11 0.691570233591404 1.95578529804842e-09 miRNAWalker2_validate -0.113326790333809 0.0030034197757431 NA NA NA hsa-let-7c-5p RFWD3 -1.70744661345097 2.87934212005942e-20 0.435632342748586 1.3132101658858e-06 miRNAWalker2_validate -0.125524002210606 2.35908018598628e-08 NA NA NA hsa-let-7c-5p RFX5 -1.70744661345097 2.87934212005942e-20 1.21360829628678 2.49921334600813e-28 MirTarget -0.142572635491316 1.08560294572442e-06 NA NA NA hsa-let-7b-5p RNF5 -0.959013717270803 5.95127281258643e-11 -0.0831413327014401 0.402509890755881 MirTarget -0.136199369705261 2.10328944377576e-05 NA NA NA hsa-let-7d-5p RNF5 0.0503292020123807 0.702580311853671 -0.0831413327014401 0.402509890755881 MirTarget -0.168302628884493 4.00467785211916e-06 NA NA NA hsa-let-7a-5p RNF7 -0.328069937201898 0.000464344093744051 0.178579961837597 0.00925796967230225 TargetScan -0.203311238244724 7.76551023182764e-09 NA NA NA hsa-let-7b-5p RPAP1 -0.959013717270803 5.95127281258643e-11 0.52318599314994 9.38361264157267e-14 miRNAWalker2_validate -0.114801346842476 7.66436273903748e-07 NA NA NA hsa-let-7b-5p RPL12 -0.959013717270803 5.95127281258643e-11 0.0965026969053291 0.43730096362171 miRNAWalker2_validate -0.169965322100354 2.26133149862094e-05 NA NA NA hsa-let-7b-5p RPL18 -0.959013717270803 5.95127281258643e-11 0.309193378881851 0.0160265868824651 miRNAWalker2_validate -0.196315372993361 2.2096119322093e-06 NA NA NA hsa-let-7b-5p RPL18A -0.959013717270803 5.95127281258643e-11 0.302238061682566 0.0189119255010824 miRNAWalker2_validate -0.17103493018462 4.15589545757533e-05 NA NA NA hsa-let-7c-5p RPL18A -1.70744661345097 2.87934212005942e-20 0.302238061682566 0.0189119255010824 miRNAWalker2_validate -0.183702992224943 7.94319049679231e-09 NA NA NA hsa-let-7a-5p RPL30 -0.328069937201898 0.000464344093744051 0.688689376323062 1.36420983994633e-06 miRNAWalker2_validate -0.357979481339963 1.70805780667716e-06 NA NA NA hsa-let-7a-5p RPL35A -0.328069937201898 0.000464344093744051 0.404680142512632 0.000571077401599864 miRNAWalker2_validate -0.280620945072339 4.58371579769122e-06 NA NA NA hsa-let-7a-5p RPL4 -0.328069937201898 0.000464344093744051 0.209510295689823 0.0521004595612059 miRNAWalker2_validate -0.292171336882487 1.56706226134418e-07 NA NA NA hsa-let-7a-5p RPL9 -0.328069937201898 0.000464344093744051 0.144415569659976 0.623305161466538 miRNAWalker2_validate -0.421115018381818 0.00617329324753109 NA NA NA hsa-let-7a-5p RPS10 -0.328069937201898 0.000464344093744051 0.628534632895926 3.61831272981553e-06 miRNAWalker2_validate -0.310615928443448 1.30933260034791e-05 NA NA NA hsa-let-7a-5p RPS13 -0.328069937201898 0.000464344093744051 0.0402954151984805 0.688921058276665 miRNAWalker2_validate -0.23590156317431 5.87260958899506e-06 NA NA NA hsa-let-7c-5p RPS13 -1.70744661345097 2.87934212005942e-20 0.0402954151984805 0.688921058276665 miRNAWalker2_validate -0.10218446432348 4.42586947280731e-05 NA NA NA hsa-let-7a-5p RPS15A -0.328069937201898 0.000464344093744051 0.0805155076461457 0.482072772357881 miRNAWalker2_validate -0.27673170226431 3.01499908260542e-06 NA NA NA hsa-let-7a-5p RPS24 -0.328069937201898 0.000464344093744051 0.267883090577552 0.0468033270606586 miRNAWalker2_validate -0.335444955807039 1.57580782357663e-06 NA NA NA hsa-let-7b-5p RPS24 -0.959013717270803 5.95127281258643e-11 0.267883090577552 0.0468033270606586 miRNAWalker2_validate -0.231414526059271 9.27766409403112e-08 NA NA NA hsa-let-7c-5p RPS24 -1.70744661345097 2.87934212005942e-20 0.267883090577552 0.0468033270606586 miRNAWalker2_validate -0.196549606512263 3.44029551262791e-09 NA NA NA hsa-let-7a-5p RPS3A -0.328069937201898 0.000464344093744051 0.0883716634600722 0.414113779996351 miRNAWalker2_validate -0.27984697496947 5.45813066467404e-07 NA NA NA hsa-let-7a-5p RPS4X -0.328069937201898 0.000464344093744051 0.174299264770649 0.133780359830453 miRNAWalker2_validate -0.259054679384097 1.75843618230099e-05 NA NA NA hsa-let-7b-5p RPS4X -0.959013717270803 5.95127281258643e-11 0.174299264770649 0.133780359830453 miRNAWalker2_validate -0.16187362844092 1.61889698832228e-05 NA NA NA hsa-let-7a-5p RPSA -0.328069937201898 0.000464344093744051 0.668412826759986 4.11902955873553e-07 miRNAWalker2_validate -0.348334798114626 4.87910255223293e-07 NA NA NA hsa-let-7b-5p RPSA -0.959013717270803 5.95127281258643e-11 0.668412826759986 4.11902955873553e-07 miRNAWalker2_validate -0.238524815591277 2.78446104472642e-08 NA NA NA hsa-let-7a-5p RPUSD2 -0.328069937201898 0.000464344093744051 0.164001572151573 0.0360631793061288 MirTarget;TargetScan;miRNATAP -0.107175519767998 0.00862246253730849 NA NA NA hsa-let-7b-5p RPUSD2 -0.959013717270803 5.95127281258643e-11 0.164001572151573 0.0360631793061288 MirTarget;miRNATAP -0.137877317626017 3.65720577851972e-08 NA NA NA hsa-let-7d-5p RPUSD2 0.0503292020123807 0.702580311853671 0.164001572151573 0.0360631793061288 miRNAWalker2_validate;MirTarget;miRNATAP -0.171126786218514 1.91531846787032e-09 NA NA NA hsa-let-7a-5p RPUSD3 -0.328069937201898 0.000464344093744051 0.215870427499803 0.0178347591150649 MirTarget -0.259335749858524 3.36399464809853e-08 NA NA NA hsa-let-7b-5p RPUSD3 -0.959013717270803 5.95127281258643e-11 0.215870427499803 0.0178347591150649 MirTarget -0.256757379937633 1.37497537196321e-19 NA NA NA hsa-let-7d-5p RPUSD3 0.0503292020123807 0.702580311853671 0.215870427499803 0.0178347591150649 MirTarget -0.177979895191612 1.00803997380515e-07 NA NA NA hsa-let-7a-5p RRAGD -0.328069937201898 0.000464344093744051 0.728091057482102 3.93159084114385e-05 TargetScan;miRNATAP -0.387305607169481 3.07353048089487e-05 NA NA NA hsa-let-7b-5p RRAGD -0.959013717270803 5.95127281258643e-11 0.728091057482102 3.93159084114385e-05 miRNATAP -0.280693411866719 1.10072912425677e-06 NA NA NA hsa-let-7a-5p RRM2 -0.328069937201898 0.000464344093744051 3.28040567179396 1.92251546747087e-44 miRNAWalker2_validate;TargetScan;miRNATAP -0.421236541054937 0.00211660207973074 NA NA NA hsa-let-7b-5p RRM2 -0.959013717270803 5.95127281258643e-11 3.28040567179396 1.92251546747087e-44 miRNAWalker2_validate;miRNATAP -0.510760525666518 1.14461203495486e-09 NA NA NA hsa-let-7b-5p RRP7A -0.959013717270803 5.95127281258643e-11 0.297341032317147 0.0127692638536425 miRNAWalker2_validate -0.126036090615763 0.001176205023856 NA NA NA hsa-let-7b-5p RRP8 -0.959013717270803 5.95127281258643e-11 -0.115274024128074 0.141596557176717 miRNAWalker2_validate -0.117491684783657 3.10699827420888e-06 NA NA NA hsa-let-7d-5p RSPO2 0.0503292020123807 0.702580311853671 -1.47503442551075 0.000466618278395286 MirTarget;miRNATAP -0.446174695431147 0.00468985802958146 NA NA NA hsa-let-7d-5p RUFY3 0.0503292020123807 0.702580311853671 -0.167328582250438 0.0586023248409221 MirTarget;miRNATAP -0.131581910438742 5.54111946610343e-05 NA NA NA hsa-let-7b-5p RXRB -0.959013717270803 5.95127281258643e-11 0.472747525482658 8.60667845282144e-09 miRNAWalker2_validate -0.128878536591037 1.61911370725303e-06 NA NA NA hsa-let-7b-5p SCAMP3 -0.959013717270803 5.95127281258643e-11 1.20056451579604 1.63329457117019e-29 miRNAWalker2_validate -0.218341607153332 2.40501167176739e-09 NA NA NA hsa-let-7b-5p SCD -0.959013717270803 5.95127281258643e-11 -0.23960201269186 0.387988088797976 miRNAWalker2_validate;MirTarget;miRNATAP -0.191417620129681 0.0344554918876619 NA NA NA hsa-let-7b-5p SCML2 -0.959013717270803 5.95127281258643e-11 1.10658718457286 8.54027458479512e-10 miRNAWalker2_validate -0.292828284197274 8.17938666859586e-07 NA NA NA hsa-let-7a-5p SEMA3F -0.328069937201898 0.000464344093744051 1.45777080905473 1.56816209923569e-37 MirTarget;miRNATAP -0.221904279756288 0.000661211931694049 NA NA NA hsa-let-7b-5p SEMA3F -0.959013717270803 5.95127281258643e-11 1.45777080905473 1.56816209923569e-37 MirTarget;miRNATAP -0.242462357841915 1.28235053198059e-09 NA NA NA hsa-let-7c-5p SEMA3F -1.70744661345097 2.87934212005942e-20 1.45777080905473 1.56816209923569e-37 MirTarget -0.234818872817101 1.05143991596871e-14 NA NA NA hsa-let-7c-5p SEMA4F -1.70744661345097 2.87934212005942e-20 1.01208582172754 6.47089148904579e-05 MirTarget -0.273087481441457 1.81190606874631e-05 NA NA NA hsa-let-7b-5p SEPT4 -0.959013717270803 5.95127281258643e-11 -0.927841220012176 0.000129941998059875 miRNAWalker2_validate -0.196777894447986 0.0134860225273693 NA NA NA hsa-let-7c-5p SF3B4 -1.70744661345097 2.87934212005942e-20 1.02312871885638 7.99127216761014e-26 miRNAWalker2_validate -0.218936273994718 1.52946844995903e-18 NA NA NA hsa-let-7a-5p SHMT2 -0.328069937201898 0.000464344093744051 -0.600660146664076 1.17270217005651e-08 miRNAWalker2_validate -0.114306079708607 0.0415926191008458 NA NA NA hsa-let-7b-5p SIGMAR1 -0.959013717270803 5.95127281258643e-11 -0.198542497125739 0.0828386785756541 miRNAWalker2_validate -0.140212076453722 0.00015569260306195 NA NA NA hsa-let-7a-5p SKA3 -0.328069937201898 0.000464344093744051 3.70437460242013 6.48201535159511e-47 miRNAWalker2_validate -0.368673398473422 0.0151230089604975 NA NA NA hsa-let-7c-5p SLC10A3 -1.70744661345097 2.87934212005942e-20 0.351752502448654 0.00188986179930041 miRNAWalker2_validate -0.182712057163013 5.67345250226885e-11 NA NA NA hsa-let-7a-5p SLC12A9 -0.328069937201898 0.000464344093744051 0.560252296396079 2.50476228499367e-08 TargetScan -0.163221245011047 0.00220549677988324 NA NA NA hsa-let-7c-5p SLC17A9 -1.70744661345097 2.87934212005942e-20 0.51327413401667 0.00962042525885391 MirTarget -0.198870581493571 6.13429852972486e-05 NA NA NA hsa-let-7b-5p SLC1A4 -0.959013717270803 5.95127281258643e-11 0.587017438973827 1.90599459760694e-05 miRNAWalker2_validate -0.172737798450364 0.000119524309012727 NA NA NA hsa-let-7b-5p SLC25A1 -0.959013717270803 5.95127281258643e-11 -0.0249103311144836 0.828430929916402 miRNAWalker2_validate -0.123144049724022 0.000943465486088362 NA NA NA hsa-let-7a-5p SLC25A12 -0.328069937201898 0.000464344093744051 0.447534935526188 0.0202834346616811 MirTarget -0.230946562637616 0.0225343167657366 NA NA NA hsa-let-7b-5p SLC25A12 -0.959013717270803 5.95127281258643e-11 0.447534935526188 0.0202834346616811 miRNAWalker2_validate;MirTarget -0.147167978715738 0.019466291326544 NA NA NA hsa-let-7d-5p SLC25A12 0.0503292020123807 0.702580311853671 0.447534935526188 0.0202834346616811 MirTarget -0.201113335604112 0.00511407007902605 NA NA NA hsa-let-7d-5p SLC25A18 0.0503292020123807 0.702580311853671 -1.4316478418912 3.53906683142588e-06 MirTarget;miRNATAP -0.421860632272218 0.000270425848142277 NA NA NA hsa-let-7b-5p SLC25A19 -0.959013717270803 5.95127281258643e-11 0.901547903666914 5.63089438166773e-15 miRNAWalker2_validate -0.223388645938163 5.1399565270646e-09 NA NA NA hsa-let-7a-5p SLC25A4 -0.328069937201898 0.000464344093744051 -0.472229423400244 6.16871736819633e-05 TargetScan;miRNATAP -0.127824213941404 0.0399273351402984 NA NA NA hsa-let-7a-5p SLC35D2 -0.328069937201898 0.000464344093744051 -0.05246368571781 0.611388869951697 TargetScan;miRNATAP -0.186605594542811 0.000509889939981608 NA NA NA hsa-let-7b-5p SLC35D2 -0.959013717270803 5.95127281258643e-11 -0.05246368571781 0.611388869951697 miRNATAP -0.20339404029558 6.28656211154056e-10 NA NA NA hsa-let-7b-5p SLC38A5 -0.959013717270803 5.95127281258643e-11 0.62864616063309 0.022761981107878 miRNAWalker2_validate -0.191113373110519 0.0342317204680503 NA NA NA hsa-let-7a-5p SLC38A9 -0.328069937201898 0.000464344093744051 0.247546291114161 0.00665000334266307 TargetScan;miRNATAP -0.116265544188153 0.0149209539250452 NA NA NA hsa-let-7b-5p SLC38A9 -0.959013717270803 5.95127281258643e-11 0.247546291114161 0.00665000334266307 miRNATAP -0.173789423268303 2.66440098894429e-09 NA NA NA hsa-let-7d-5p SLC4A4 0.0503292020123807 0.702580311853671 -2.23317622565422 7.81779722860372e-13 miRNATAP -0.251865303771616 0.035272390963648 NA NA NA hsa-let-7b-5p SLC5A6 -0.959013717270803 5.95127281258643e-11 0.197307436899311 0.230852494089565 MirTarget;miRNATAP -0.197395136568639 0.000217650032006527 NA NA NA hsa-let-7d-5p SLC5A6 0.0503292020123807 0.702580311853671 0.197307436899311 0.230852494089565 MirTarget;miRNATAP -0.166827066055276 0.00640874118806837 NA NA NA hsa-let-7a-5p SLC5A9 -0.328069937201898 0.000464344093744051 0.155215670846234 0.581875424836598 TargetScan;miRNATAP -0.315755942674006 0.0325155961299586 NA NA NA hsa-let-7d-5p SLC6A1 0.0503292020123807 0.702580311853671 -1.17614916548093 6.73017890737053e-05 MirTarget;miRNATAP -0.221384036194214 0.0459969867336225 NA NA NA hsa-let-7a-5p SLC6A15 -0.328069937201898 0.000464344093744051 0.497584853225585 0.14038466590646 TargetScan -0.402883929634442 0.0228218707154848 NA NA NA hsa-let-7b-5p SLC9A3R1 -0.959013717270803 5.95127281258643e-11 0.245388702175854 0.0208034453981517 miRNAWalker2_validate -0.23688323206602 2.10000626310716e-12 NA NA NA hsa-let-7a-5p SLCO5A1 -0.328069937201898 0.000464344093744051 0.673563110902495 0.0153869463632922 TargetScan;miRNATAP -0.335546591648343 0.0216008919072934 NA NA NA hsa-let-7c-5p SMARCC1 -1.70744661345097 2.87934212005942e-20 0.453331771984192 2.34444535272705e-08 miRNAWalker2_validate -0.12781175289705 2.68001045795896e-10 NA NA NA hsa-let-7b-5p SMARCD1 -0.959013717270803 5.95127281258643e-11 0.643238619401545 1.43047276243426e-17 miRNAWalker2_validate -0.120832998841253 1.66970252646906e-06 NA NA NA hsa-let-7c-5p SMARCD1 -1.70744661345097 2.87934212005942e-20 0.643238619401545 1.43047276243426e-17 miRNAWalker2_validate -0.177640467487771 1.94594245173065e-21 NA NA NA hsa-let-7c-5p SMCR8 -1.70744661345097 2.87934212005942e-20 0.453242799658724 3.50739679214307e-06 MirTarget -0.122565100231006 5.4902514084137e-07 NA NA NA hsa-let-7a-5p SMUG1 -0.328069937201898 0.000464344093744051 0.20250290453286 0.0184329232142982 TargetScan -0.212232497668928 1.8159061011853e-06 NA NA NA hsa-let-7b-5p SNRPA -0.959013717270803 5.95127281258643e-11 0.715213729046863 1.13843031326507e-13 miRNAWalker2_validate -0.218393353102979 4.19044028579875e-12 NA NA NA hsa-let-7a-5p SNRPC -0.328069937201898 0.000464344093744051 0.791879055081323 1.95373526756218e-14 miRNAWalker2_validate -0.31332049899606 1.24175496344508e-08 NA NA NA hsa-let-7b-5p SNRPE -0.959013717270803 5.95127281258643e-11 1.03768820293814 1.39601848132432e-19 miRNAWalker2_validate -0.225289056946163 4.5934175499197e-09 NA NA NA hsa-let-7a-5p SOX12 -0.328069937201898 0.000464344093744051 1.13902221223852 8.89966671522395e-12 mirMAP -0.311970969702443 0.000484314705375315 NA NA NA hsa-let-7b-5p SOX12 -0.959013717270803 5.95127281258643e-11 1.13902221223852 8.89966671522395e-12 mirMAP -0.269138859833516 1.1107594275051e-06 NA NA NA hsa-let-7c-5p SOX13 -1.70744661345097 2.87934212005942e-20 0.713864896374115 5.5028190432502e-13 MirTarget -0.124273877815759 8.64473078600962e-07 NA NA NA hsa-let-7a-5p SPATS2 -0.328069937201898 0.000464344093744051 1.59671382425823 4.98846564542915e-42 miRNAWalker2_validate -0.216240001254642 0.00150313042206915 NA NA NA hsa-let-7a-5p SPOCD1 -0.328069937201898 0.000464344093744051 1.71649333129425 1.90896857812252e-09 TargetScan -0.354590455074881 0.0203850912826639 NA NA NA hsa-let-7d-5p SPRYD4 0.0503292020123807 0.702580311853671 -1.55195398609968 7.32891339162156e-27 miRNAWalker2_validate;MirTarget -0.211010008299186 0.000225787934968954 NA NA NA hsa-let-7a-5p SPTBN4 -0.328069937201898 0.000464344093744051 0.161199362895975 0.504469235737208 TargetScan;miRNATAP -0.283979226852871 0.0247608581153244 NA NA NA hsa-let-7b-5p SPTBN4 -0.959013717270803 5.95127281258643e-11 0.161199362895975 0.504469235737208 miRNATAP -0.175098593181897 0.0261145109399105 NA NA NA hsa-let-7a-5p STARD3NL -0.328069937201898 0.000464344093744051 0.140337006185873 0.201694234710223 TargetScan -0.174018122456321 0.00240012936514227 NA NA NA hsa-let-7b-5p STIP1 -0.959013717270803 5.95127281258643e-11 0.881592573467585 2.72913968310461e-22 miRNAWalker2_validate -0.195508341788638 1.44051230947563e-10 NA NA NA hsa-let-7d-5p STK40 0.0503292020123807 0.702580311853671 -0.821847220109252 4.78818932052572e-18 miRNAWalker2_validate;MirTarget;miRNATAP -0.163207764790744 7.6265730752924e-06 NA NA NA hsa-let-7a-5p STX3 -0.328069937201898 0.000464344093744051 0.268625915502391 0.0620467313021486 MirTarget;TargetScan -0.226013965934235 0.00267536264558287 NA NA NA hsa-let-7c-5p STX3 -1.70744661345097 2.87934212005942e-20 0.268625915502391 0.0620467313021486 MirTarget -0.200597820665899 1.7582165585329e-08 NA NA NA hsa-let-7a-5p SUB1 -0.328069937201898 0.000464344093744051 0.583706814960803 1.03979976716946e-11 MirTarget;TargetScan;miRNATAP -0.132062343097165 0.00401599356680177 NA NA NA hsa-let-7c-5p SUB1 -1.70744661345097 2.87934212005942e-20 0.583706814960803 1.03979976716946e-11 MirTarget -0.151812387295251 1.54400818436745e-12 NA NA NA hsa-let-7b-5p SUMO2 -0.959013717270803 5.95127281258643e-11 0.341927037915742 3.51282355501689e-06 miRNAWalker2_validate -0.123221621979424 2.44086542281793e-07 NA NA NA hsa-let-7b-5p SYNGR2 -0.959013717270803 5.95127281258643e-11 0.449404442004785 3.03327638641744e-06 miRNAWalker2_validate -0.16566728774285 1.13378435727921e-07 NA NA NA hsa-let-7a-5p SYT1 -0.328069937201898 0.000464344093744051 -0.909227689220105 0.0299110122453997 TargetScan;miRNATAP -0.44344048643379 0.043937113564386 NA NA NA hsa-let-7b-5p SYT1 -0.959013717270803 5.95127281258643e-11 -0.909227689220105 0.0299110122453997 miRNATAP -0.42327621675761 0.0019304262766014 NA NA NA hsa-let-7a-5p TARBP2 -0.328069937201898 0.000464344093744051 0.176042111215921 0.0481918395946868 TargetScan -0.293434178781307 1.20842886831064e-10 NA NA NA hsa-let-7c-5p TAZ -1.70744661345097 2.87934212005942e-20 0.956747824088997 5.51728917847337e-22 miRNAWalker2_validate -0.160843910434223 3.98057075434146e-10 NA NA NA hsa-let-7a-5p TBC1D13 -0.328069937201898 0.000464344093744051 0.861209565504011 9.70398365961959e-16 MirTarget -0.178139244301847 0.00214468557889602 NA NA NA hsa-let-7b-5p TBC1D13 -0.959013717270803 5.95127281258643e-11 0.861209565504011 9.70398365961959e-16 miRNAWalker2_validate;MirTarget -0.215386715536668 1.34648089313991e-09 NA NA NA hsa-let-7c-5p TBC1D13 -1.70744661345097 2.87934212005942e-20 0.861209565504011 9.70398365961959e-16 MirTarget -0.174153765242454 1.81958533488793e-10 NA NA NA hsa-let-7a-5p TBKBP1 -0.328069937201898 0.000464344093744051 0.916427652689533 7.35042591752853e-10 MirTarget;TargetScan;miRNATAP -0.277649544405952 0.000460590183059352 NA NA NA hsa-let-7c-5p TBKBP1 -1.70744661345097 2.87934212005942e-20 0.916427652689533 7.35042591752853e-10 MirTarget -0.255902300442293 6.22257358099485e-12 NA NA NA hsa-let-7b-5p TBRG4 -0.959013717270803 5.95127281258643e-11 0.326607417185357 2.8050280636372e-05 miRNAWalker2_validate -0.199989127436931 4.66023543317428e-16 NA NA NA hsa-let-7b-5p TCOF1 -0.959013717270803 5.95127281258643e-11 1.06738163786709 7.82640575865382e-26 miRNAWalker2_validate -0.248694276668122 3.67834112087423e-13 NA NA NA hsa-let-7d-5p TGFBR3 0.0503292020123807 0.702580311853671 -1.53475612080717 2.32211754233392e-15 MirTarget -0.196855178961592 0.0084014005097078 NA NA NA hsa-let-7b-5p THOC5 -0.959013717270803 5.95127281258643e-11 0.746036274600697 5.59170354099161e-17 miRNAWalker2_validate -0.180422621641938 1.04782571223639e-09 NA NA NA hsa-let-7d-5p THRSP 0.0503292020123807 0.702580311853671 -4.79698481601912 8.30913075137373e-15 MirTarget -0.779539660274321 0.00103381570595081 NA NA NA hsa-let-7a-5p TIMM17B -0.328069937201898 0.000464344093744051 0.476727150145719 7.83549209041961e-07 TargetScan;miRNATAP -0.396771746392235 8.78337496544585e-16 NA NA NA hsa-let-7b-5p TIMM17B -0.959013717270803 5.95127281258643e-11 0.476727150145719 7.83549209041961e-07 miRNATAP -0.258386109573072 2.91117101723846e-17 NA NA NA hsa-let-7d-5p TIMM17B 0.0503292020123807 0.702580311853671 0.476727150145719 7.83549209041961e-07 miRNATAP -0.140628241406183 9.79717212512721e-05 NA NA NA hsa-let-7b-5p TIMM50 -0.959013717270803 5.95127281258643e-11 0.575233750732028 5.54969666641848e-09 miRNAWalker2_validate -0.224818685361982 1.66781994190981e-12 NA NA NA hsa-let-7b-5p TIMM8A -0.959013717270803 5.95127281258643e-11 0.138081926499129 0.275665951693347 miRNAWalker2_validate -0.337371161875972 1.65986714747969e-17 NA NA NA hsa-let-7b-5p TIMM9 -0.959013717270803 5.95127281258643e-11 0.416738257830572 1.95978513473177e-06 miRNAWalker2_validate -0.161358230863259 1.246142624479e-08 NA NA NA hsa-let-7b-5p TJAP1 -0.959013717270803 5.95127281258643e-11 0.700634549796933 6.17996946271343e-20 mirMAP -0.1144936228206 9.59534795972397e-06 NA NA NA hsa-let-7a-5p TMC7 -0.328069937201898 0.000464344093744051 2.03760714579858 4.07529066351364e-21 TargetScan;miRNATAP -0.32293719029842 0.00665900850038472 NA NA NA hsa-let-7a-5p TMEM104 -0.328069937201898 0.000464344093744051 0.843757768707635 5.73449815264737e-17 mirMAP -0.156183006654503 0.00433498813403487 NA NA NA hsa-let-7b-5p TMEM104 -0.959013717270803 5.95127281258643e-11 0.843757768707635 5.73449815264737e-17 mirMAP -0.201441318312726 1.83054856150417e-09 NA NA NA hsa-let-7d-5p TMEM110 0.0503292020123807 0.702580311853671 -0.263748642092995 0.0243287997140745 MirTarget -0.1154389851175 0.00806366567255629 NA NA NA hsa-let-7b-5p TMEM115 -0.959013717270803 5.95127281258643e-11 0.309432099985507 2.3283264333858e-05 miRNAWalker2_validate -0.161115620674426 5.05227599979705e-12 NA NA NA hsa-let-7c-5p TMEM165 -1.70744661345097 2.87934212005942e-20 0.581530725593331 1.55109884568793e-08 miRNAWalker2_validate -0.144842845795178 2.038268418118e-08 NA NA NA hsa-let-7a-5p TMEM167A -0.328069937201898 0.000464344093744051 0.212640777093779 0.00146514175351927 MirTarget;TargetScan -0.191606129039381 2.54899226993853e-08 NA NA NA hsa-let-7b-5p TMEM167A -0.959013717270803 5.95127281258643e-11 0.212640777093779 0.00146514175351927 miRNAWalker2_validate;MirTarget -0.138983475602183 6.24159486759089e-11 NA NA NA hsa-let-7d-5p TMEM167A 0.0503292020123807 0.702580311853671 0.212640777093779 0.00146514175351927 MirTarget -0.102050597098865 3.4726424964135e-05 NA NA NA hsa-let-7c-5p TMEM184B -1.70744661345097 2.87934212005942e-20 0.889593464258157 1.1912658512836e-19 miRNAWalker2_validate -0.170532146688534 1.19223629021959e-11 NA NA NA hsa-let-7b-5p TMEM201 -0.959013717270803 5.95127281258643e-11 1.26425577239023 2.24180741272478e-27 miRNAWalker2_validate -0.156883236891586 0.000102363092316617 NA NA NA hsa-let-7a-5p TMEM64 -0.328069937201898 0.000464344093744051 -0.00136604960589803 0.993609309009731 miRNAWalker2_validate -0.255075261387471 0.00418850905744519 NA NA NA hsa-let-7a-5p TMX2 -0.328069937201898 0.000464344093744051 0.126965997581665 0.0601196314727116 miRNAWalker2_validate -0.127784957778705 0.000260747662179057 NA NA NA hsa-let-7d-5p TNFRSF1B 0.0503292020123807 0.702580311853671 -0.842653559102565 4.93648097238325e-09 MirTarget;miRNATAP -0.11297915178773 0.0387760978535582 NA NA NA hsa-let-7a-5p TNFSF9 -0.328069937201898 0.000464344093744051 0.433957241730842 0.14693880225636 TargetScan -0.402117018873366 0.010305536180038 NA NA NA hsa-let-7b-5p TPD52L2 -0.959013717270803 5.95127281258643e-11 0.739635243205164 1.38690072288043e-18 miRNAWalker2_validate -0.190982791039056 6.89619624302351e-12 NA NA NA hsa-let-7a-5p TRAF7 -0.328069937201898 0.000464344093744051 0.490515689731511 1.90248621875632e-08 miRNAWalker2_validate -0.128130249568884 0.00564640891307104 NA NA NA hsa-let-7b-5p TRAPPC1 -0.959013717270803 5.95127281258643e-11 0.174428158942158 0.113231580831674 miRNAWalker2_validate -0.160883114426891 5.91266981797949e-06 NA NA NA hsa-let-7b-5p TRIM24 -0.959013717270803 5.95127281258643e-11 0.404877930882101 0.00021657771120412 miRNAWalker2_validate -0.122304053861603 0.000618370529894173 NA NA NA hsa-let-7b-5p TRIM28 -0.959013717270803 5.95127281258643e-11 0.651853250493276 7.91407664709318e-12 miRNAWalker2_validate -0.164812886203474 1.52104733143263e-07 NA NA NA hsa-let-7a-5p TRIM41 -0.328069937201898 0.000464344093744051 0.213322301196652 0.00831557893846543 TargetScan;miRNATAP -0.11101550945515 0.00858260779865237 NA NA NA hsa-let-7b-5p TRIM41 -0.959013717270803 5.95127281258643e-11 0.213322301196652 0.00831557893846543 miRNATAP -0.101068075405408 0.000111689940695834 NA NA NA hsa-let-7d-5p TRIM41 0.0503292020123807 0.702580311853671 0.213322301196652 0.00831557893846543 miRNATAP -0.162303541169361 4.20640453342208e-08 NA NA NA hsa-let-7b-5p TRIM66 -0.959013717270803 5.95127281258643e-11 0.807068904444835 4.08730410631591e-10 mirMAP -0.149058340820993 0.000497629991729155 NA NA NA hsa-let-7d-5p TRIM66 0.0503292020123807 0.702580311853671 0.807068904444835 4.08730410631591e-10 mirMAP -0.116169147086588 0.0179364588391846 NA NA NA hsa-let-7c-5p TRIM67 -1.70744661345097 2.87934212005942e-20 0.526474972444801 0.0261906603203476 MirTarget -0.221979298256235 0.000181660256380273 NA NA NA hsa-let-7a-5p TRIM71 -0.328069937201898 0.000464344093744051 1.88705329759216 3.31797883877253e-06 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.718728557944018 0.000807355330006894 23097274 Lin-41 is a stem cell-specific E3 ligase and a known target of the tumour suppressor microRNA miRNA let-7 liver cancer hsa-let-7b-5p TRIM71 -0.959013717270803 5.95127281258643e-11 1.88705329759216 3.31797883877253e-06 MirTarget -0.491774000925243 0.000225044317759829 23097274 Lin-41 is a stem cell-specific E3 ligase and a known target of the tumour suppressor microRNA miRNA let-7 liver cancer hsa-let-7c-5p TRIM71 -1.70744661345097 2.87934212005942e-20 1.88705329759216 3.31797883877253e-06 miRNAWalker2_validate;MirTarget -0.78785120052045 2.91205218598371e-15 NA NA NA hsa-let-7b-5p TRMT1 -0.959013717270803 5.95127281258643e-11 0.858290013298862 6.82759417691173e-19 miRNAWalker2_validate -0.235854965038897 1.54006743492728e-13 NA NA NA hsa-let-7a-5p TRPM6 -0.328069937201898 0.000464344093744051 -0.272519532316722 0.350297084628655 TargetScan;miRNATAP -0.402321288954823 0.00842518288530727 NA NA NA hsa-let-7b-5p TRPM6 -0.959013717270803 5.95127281258643e-11 -0.272519532316722 0.350297084628655 miRNATAP -0.355982613549219 0.000168341391017747 NA NA NA hsa-let-7d-5p TRPM6 0.0503292020123807 0.702580311853671 -0.272519532316722 0.350297084628655 miRNATAP -0.332667024592289 0.00214141355428401 NA NA NA hsa-let-7b-5p TRUB2 -0.959013717270803 5.95127281258643e-11 -0.318886643146548 0.000504047534238495 miRNAWalker2_validate -0.118649838943071 6.76205323000608e-05 NA NA NA hsa-let-7a-5p TSEN34 -0.328069937201898 0.000464344093744051 0.266157488915585 0.00096404193488079 MirTarget -0.159488015356936 0.000148640346595609 NA NA NA hsa-let-7b-5p TSEN34 -0.959013717270803 5.95127281258643e-11 0.266157488915585 0.00096404193488079 MirTarget -0.112189033675839 1.71896786050409e-05 NA NA NA hsa-let-7d-5p TST 0.0503292020123807 0.702580311853671 -0.774941778981919 2.5527348136343e-06 miRNAWalker2_validate -0.286994808334097 3.00932187147819e-06 NA NA NA hsa-let-7a-5p TTLL4 -0.328069937201898 0.000464344093744051 1.09772685973996 1.47068858470308e-10 MirTarget;TargetScan;miRNATAP -0.358321957594003 8.65227370416744e-05 NA NA NA hsa-let-7b-5p TTLL4 -0.959013717270803 5.95127281258643e-11 1.09772685973996 1.47068858470308e-10 MirTarget;miRNATAP -0.275113543084607 1.13009557957738e-06 NA NA NA hsa-let-7c-5p TTLL4 -1.70744661345097 2.87934212005942e-20 1.09772685973996 1.47068858470308e-10 MirTarget -0.450426278450796 7.57793283588566e-28 NA NA NA hsa-let-7b-5p TUBA1B -0.959013717270803 5.95127281258643e-11 0.963999859942387 5.81129142557304e-19 miRNAWalker2_validate -0.210539535131666 6.51668864508627e-09 NA NA NA hsa-let-7b-5p TUBA1C -0.959013717270803 5.95127281258643e-11 0.592525992104057 2.64033203642077e-06 miRNAWalker2_validate -0.167980802593379 4.73798038206838e-05 NA NA NA hsa-let-7b-5p TUBB -0.959013717270803 5.95127281258643e-11 0.440385637856354 1.66050745125373e-05 miRNAWalker2_validate -0.120734842922935 0.000304776641470641 NA NA NA hsa-let-7a-5p TUSC2 -0.328069937201898 0.000464344093744051 0.375874430337742 3.43588537231975e-05 miRNAWalker2_validate;TargetScan;miRNATAP -0.287243619444198 9.08278453218434e-10 NA NA NA hsa-let-7b-5p TUSC2 -0.959013717270803 5.95127281258643e-11 0.375874430337742 3.43588537231975e-05 miRNATAP -0.248804302638324 2.77191372675254e-18 NA NA NA hsa-let-7d-5p TUSC2 0.0503292020123807 0.702580311853671 0.375874430337742 3.43588537231975e-05 miRNATAP -0.113243865293576 0.000822934168806733 NA NA NA hsa-let-7a-5p TXLNA -0.328069937201898 0.000464344093744051 0.11994660168127 0.117719419637702 TargetScan;miRNATAP -0.126458315127119 0.001508378504489 NA NA NA hsa-let-7b-5p TXNL4A -0.959013717270803 5.95127281258643e-11 0.460024839629078 7.67152474765342e-06 miRNAWalker2_validate -0.190944625628549 9.29738188188459e-09 NA NA NA hsa-let-7b-5p TYMS -0.959013717270803 5.95127281258643e-11 1.73887296208296 3.38348708195271e-19 miRNAWalker2_validate -0.287978882083457 1.18438315128172e-05 NA NA NA hsa-let-7c-5p UBA52 -1.70744661345097 2.87934212005942e-20 0.28393248928586 0.0110134022626622 miRNAWalker2_validate -0.106594975606236 0.000134675405654401 NA NA NA hsa-let-7b-5p UBAP2L -0.959013717270803 5.95127281258643e-11 0.971939144855086 1.81359192544576e-28 miRNAWalker2_validate -0.101356092942682 0.000894046090958441 NA NA NA hsa-let-7b-5p UBE2D2 -0.959013717270803 5.95127281258643e-11 0.245532981651438 3.42029764206399e-05 miRNAWalker2_validate -0.112731424085437 2.79378638818405e-09 NA NA NA hsa-let-7b-5p UBE2I -0.959013717270803 5.95127281258643e-11 0.437225260766186 9.08527064616308e-09 miRNAWalker2_validate -0.149640881343824 1.30615433746375e-09 NA NA NA hsa-let-7b-5p UBE2M -0.959013717270803 5.95127281258643e-11 0.588142814934092 9.35090745734134e-10 miRNAWalker2_validate -0.192850479674134 7.13052338262029e-10 NA NA NA hsa-let-7a-5p UBFD1 -0.328069937201898 0.000464344093744051 0.109959650870342 0.181356823499568 miRNATAP -0.129251491462074 0.00253244666697083 NA NA NA hsa-let-7b-5p UCK2 -0.959013717270803 5.95127281258643e-11 1.18360816028226 8.55973566464538e-22 miRNAWalker2_validate -0.312886281485573 2.49987219028776e-14 NA NA NA hsa-let-7b-5p UGT8 -0.959013717270803 5.95127281258643e-11 0.668138341470101 0.0469987718329836 miRNAWalker2_validate -0.526311662982663 1.28307823011629e-06 NA NA NA hsa-let-7b-5p UHRF1 -0.959013717270803 5.95127281258643e-11 3.49841769196073 9.81871544089538e-40 miRNAWalker2_validate -0.288344181665265 0.00248395110355204 NA NA NA hsa-let-7b-5p USP14 -0.959013717270803 5.95127281258643e-11 0.448335849885336 1.34580227812328e-09 miRNAWalker2_validate -0.107893822577806 8.75057315805011e-06 NA NA NA hsa-let-7b-5p USP22 -0.959013717270803 5.95127281258643e-11 0.620225817612547 2.78559526456339e-10 miRNAWalker2_validate -0.10753538197954 0.000962521521170467 NA NA NA hsa-let-7d-5p USP32 0.0503292020123807 0.702580311853671 -0.294622923243741 0.00152102677975573 MirTarget -0.100013154442906 0.00383419979454234 NA NA NA hsa-let-7d-5p USP38 0.0503292020123807 0.702580311853671 -1.03326457838017 5.36170633921046e-21 MirTarget;miRNATAP -0.127749862374476 0.00288939328300425 NA NA NA hsa-let-7b-5p USP54 -0.959013717270803 5.95127281258643e-11 0.621564566787767 0.00139361741036206 miRNAWalker2_validate -0.208721535234035 0.00101526173400137 NA NA NA hsa-let-7b-5p UTP15 -0.959013717270803 5.95127281258643e-11 0.374519402023179 6.78274618257908e-07 miRNAWalker2_validate -0.120491571298561 8.76268515272731e-07 NA NA NA hsa-let-7b-5p UTP6 -0.959013717270803 5.95127281258643e-11 0.453001905905601 1.36541889678502e-11 miRNAWalker2_validate -0.17007244775853 2.71918532993786e-15 NA NA NA hsa-let-7a-5p VASH2 -0.328069937201898 0.000464344093744051 1.99409120294188 1.83824386478745e-12 TargetScan;miRNATAP -0.444121209099365 0.00354652208523396 NA NA NA hsa-let-7b-5p VASH2 -0.959013717270803 5.95127281258643e-11 1.99409120294188 1.83824386478745e-12 miRNATAP -0.34969897962803 0.000214609696365423 NA NA NA hsa-let-7b-5p VPS28 -0.959013717270803 5.95127281258643e-11 0.713494145604384 2.78580979609343e-07 miRNAWalker2_validate -0.235169849044216 2.10444323959951e-07 NA NA NA hsa-let-7b-5p VSNL1 -0.959013717270803 5.95127281258643e-11 -0.874873254541304 0.0199688194916894 miRNATAP -0.458458931109548 0.000177436456783907 NA NA NA hsa-let-7a-5p WARS2 -0.328069937201898 0.000464344093744051 0.101003270315102 0.223459540455861 TargetScan -0.107429805558217 0.0129783235672186 NA NA NA hsa-let-7b-5p WARS2 -0.959013717270803 5.95127281258643e-11 0.101003270315102 0.223459540455861 miRNAWalker2_validate -0.109240612676114 4.40140887755695e-05 NA NA NA hsa-let-7b-5p WDR4 -0.959013717270803 5.95127281258643e-11 0.911536528485952 5.83780925869124e-15 miRNAWalker2_validate -0.249721846170149 8.8023423770075e-11 NA NA NA hsa-let-7a-5p WDR46 -0.328069937201898 0.000464344093744051 0.653864898731985 2.24549793686139e-12 miRNAWalker2_validate -0.199155745396513 6.19297858423334e-05 NA NA NA hsa-let-7b-5p WDR55 -0.959013717270803 5.95127281258643e-11 0.2680872294187 0.000406680162601839 miRNAWalker2_validate -0.117369553948986 1.63283588152435e-06 NA NA NA hsa-let-7b-5p WDR74 -0.959013717270803 5.95127281258643e-11 0.146465986359561 0.149793869030523 miRNAWalker2_validate -0.170032508626088 1.90085558880823e-07 NA NA NA hsa-let-7a-5p WIPI2 -0.328069937201898 0.000464344093744051 0.170521508783927 0.0184021828910785 miRNAWalker2_validate;TargetScan -0.125369870015824 0.000859573945848967 NA NA NA hsa-let-7b-5p XK -0.959013717270803 5.95127281258643e-11 -0.0687893108583119 0.855569325237923 miRNATAP -0.316001901844644 0.0102400793283692 NA NA NA hsa-let-7d-5p XK 0.0503292020123807 0.702580311853671 -0.0687893108583119 0.855569325237923 miRNATAP -0.492044588352124 0.000443458160983174 NA NA NA hsa-let-7a-5p XKR8 -0.328069937201898 0.000464344093744051 -0.231756162006961 0.0283383051287292 MirTarget;TargetScan;miRNATAP -0.130227952453927 0.0186067898753705 NA NA NA hsa-let-7b-5p XPO5 -0.959013717270803 5.95127281258643e-11 0.924250934584309 5.58683264436527e-22 miRNAWalker2_validate -0.209085738467015 8.15016706413123e-11 NA NA NA hsa-let-7b-5p XYLT2 -0.959013717270803 5.95127281258643e-11 0.579893404274664 1.55648702486902e-11 miRNAWalker2_validate -0.115011317888523 5.36364687622521e-05 NA NA NA hsa-let-7b-5p YIPF3 -0.959013717270803 5.95127281258643e-11 0.470730380289489 1.65755380104256e-08 miRNAWalker2_validate -0.147644316108059 5.47927413154812e-08 NA NA NA hsa-let-7a-5p ZC3H3 -0.328069937201898 0.000464344093744051 1.0612730707833 1.57569638197004e-20 MirTarget;TargetScan;miRNATAP -0.231125568411855 0.000216804002188298 NA NA NA hsa-let-7b-5p ZC3H3 -0.959013717270803 5.95127281258643e-11 1.0612730707833 1.57569638197004e-20 MirTarget;miRNATAP -0.239376577135104 4.12019608876895e-10 NA NA NA hsa-let-7c-5p ZC3H3 -1.70744661345097 2.87934212005942e-20 1.0612730707833 1.57569638197004e-20 MirTarget -0.199043730435108 1.27659419619969e-11 NA NA NA hsa-let-7a-5p ZCCHC9 -0.328069937201898 0.000464344093744051 0.393815108762661 6.36455211058042e-05 miRNAWalker2_validate -0.247471287771509 1.42946681202225e-06 NA NA NA hsa-let-7b-5p ZCCHC9 -0.959013717270803 5.95127281258643e-11 0.393815108762661 6.36455211058042e-05 miRNAWalker2_validate -0.24601417419315 3.26707475776122e-15 NA NA NA hsa-let-7a-5p ZNF341 -0.328069937201898 0.000464344093744051 1.14203694186585 2.09883489981705e-26 TargetScan -0.236182072266449 7.32835908292182e-05 NA NA NA hsa-let-7b-5p ZNF343 -0.959013717270803 5.95127281258643e-11 0.386684603484914 2.23803553768918e-06 miRNATAP -0.101059083949527 0.000154634598230348 NA NA NA hsa-let-7a-5p ZNF512B -0.328069937201898 0.000464344093744051 0.949756749303405 1.79541489585724e-18 MirTarget;TargetScan;miRNATAP -0.170526068611452 0.00389677249323807 NA NA NA hsa-let-7b-5p ZNF512B -0.959013717270803 5.95127281258643e-11 0.949756749303405 1.79541489585724e-18 MirTarget;miRNATAP -0.19610448926873 6.6295765533596e-08 NA NA NA hsa-let-7c-5p ZNF512B -1.70744661345097 2.87934212005942e-20 0.949756749303405 1.79541489585724e-18 MirTarget -0.178134616117144 1.43198078159576e-10 NA NA NA hsa-let-7c-5p ZNF526 -1.70744661345097 2.87934212005942e-20 0.694364272257119 1.11242011006087e-21 miRNAWalker2_validate -0.147571959257241 1.3126555892882e-15 NA NA NA hsa-let-7b-5p ZNF581 -0.959013717270803 5.95127281258643e-11 1.08114010713937 1.93294426178797e-17 miRNAWalker2_validate -0.273408035006335 9.75259219435384e-11 NA NA NA hsa-let-7c-5p ZNF581 -1.70744661345097 2.87934212005942e-20 1.08114010713937 1.93294426178797e-17 miRNAWalker2_validate -0.315580993313553 1.10992003321011e-23 NA NA NA hsa-let-7c-5p ZNF710 -1.70744661345097 2.87934212005942e-20 0.313248196006383 0.103373907581206 MirTarget -0.120535446215635 0.0125911174137927 NA NA NA hsa-let-7a-5p ZNF740 -0.328069937201898 0.000464344093744051 0.890272260761446 1.12335939218223e-24 TargetScan -0.121025528425998 0.0118992315429202 NA NA NA hsa-let-7a-5p ZNRF1 -0.328069937201898 0.000464344093744051 -0.110786484068049 0.240577119995332 mirMAP -0.148433912836043 0.0025400690310487 NA NA NA hsa-let-7a-5p ZSWIM5 -0.328069937201898 0.000464344093744051 1.1829090996225 0.000142288273228735 TargetScan;miRNATAP -0.548078770828907 0.000811494547733639 NA NA NA hsa-let-7b-5p ZSWIM5 -0.959013717270803 5.95127281258643e-11 1.1829090996225 0.000142288273228735 miRNATAP -0.576102714959645 1.00373621992069e-08 NA NA NA