miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106b-5p AKT3 2.80565545918114 1.14547999022566e-09 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.411504731855899 9.49650030459631e-06 NA NA NA hsa-miR-142-3p AKT3 4.35304505457969 3.10014573651358e-10 -3.32677676487603 1.45486698220293e-05 miRanda -0.161022651130634 0.00933730307368185 NA NA NA hsa-miR-15a-5p AKT3 2.0535411006904 1.91108976398046e-06 -3.32677676487603 1.45486698220293e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.374578960806042 0.000213935533400346 NA NA NA hsa-miR-15b-5p AKT3 3.32329949959268 8.40210501034588e-13 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.254367737995205 0.00570754876367863 NA NA NA hsa-miR-16-5p AKT3 2.93575808220754 2.15436817162977e-10 -3.32677676487603 1.45486698220293e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309870666150618 0.000864570425925272 NA NA NA hsa-miR-29b-3p AKT3 0.666547117072858 0.234055379278093 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.283935483475042 0.000311340903637634 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 2.14185373842821 0.0609400502269891 -3.32677676487603 1.45486698220293e-05 mirMAP -0.221762461081726 2.87831776854007e-06 NA NA NA hsa-miR-362-3p AKT3 0.679952485897744 0.226148468488576 -3.32677676487603 1.45486698220293e-05 miRanda -0.254988730314174 0.00123561088951897 NA NA NA hsa-miR-501-3p AKT3 1.72239979688923 0.0075900263732748 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.18288683695833 0.00732967244086728 NA NA NA hsa-miR-93-5p AKT3 2.65964181833033 2.58315947526774e-08 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.334744595445174 0.000214241376596223 NA NA NA hsa-miR-149-5p ARRB1 1.18551753240939 0.197439607622379 -1.73555965434595 0.00701332203991661 MirTarget -0.194614869477017 6.89317763587227e-07 NA NA NA hsa-miR-219a-1-3p ARRB1 2.00224769738217 0.0010023437369814 -1.73555965434595 0.00701332203991661 MirTarget -0.187037071129457 0.00176455104558477 NA NA NA hsa-miR-22-3p ARRB1 0.845430028554782 0.0148923883819448 -1.73555965434595 0.00701332203991661 MirTarget -0.285485836507929 0.00787083540281153 NA NA NA hsa-miR-92a-3p ARRB1 1.87892405805529 1.27013821556583e-05 -1.73555965434595 0.00701332203991661 miRNAWalker2_validate -0.307522757817853 0.000272691618321051 NA NA NA hsa-miR-365a-3p ARRB2 0.25545896241765 0.654320504621012 0.389241281777482 0.310249636130035 MirTarget;miRNATAP -0.108953081586807 0.00427883488548572 NA NA NA hsa-miR-221-3p ATF2 0.94082283577318 0.174749164179978 0.255006508462589 0.638329767176427 MirTarget -0.166160760729464 0.000161631962462298 NA NA NA hsa-miR-222-3p ATF2 1.54730827524553 0.0223014220569407 0.255006508462589 0.638329767176427 MirTarget -0.170301458106441 0.000153202963405891 NA NA NA hsa-miR-26a-5p ATF2 -0.352368463397074 0.362040749917446 0.255006508462589 0.638329767176427 MirTarget;miRNATAP -0.216144927184294 0.00740224566985116 NA NA NA hsa-miR-29a-5p ATF2 0.0748295222568571 0.884125894063293 0.255006508462589 0.638329767176427 MirTarget;miRNATAP -0.214540960601064 0.000346003798054337 NA NA NA hsa-miR-30e-5p ATF2 0.780047227271616 0.0346714425913016 0.255006508462589 0.638329767176427 mirMAP -0.258612320308903 0.00214347813505889 NA NA NA hsa-miR-590-3p ATF2 2.35429565068338 2.79601879608564e-06 0.255006508462589 0.638329767176427 MirTarget;miRanda;mirMAP;miRNATAP -0.225484723256455 0.000177772009229216 NA NA NA hsa-miR-1-3p BDNF -3.85397883903804 6.93274972711165e-06 1.9301309436685 0.15402934773225 miRTarBase;MirTarget -0.238246139789509 0.00699566300603736 NA NA NA hsa-miR-146b-5p BDNF 1.87569569182453 0.000737241069698886 1.9301309436685 0.15402934773225 miRanda -0.397605085388184 0.00388699211645475 NA NA NA hsa-miR-146b-5p BRAF 1.87569569182453 0.000737241069698886 0.872465997831152 0.0211592092766493 miRanda -0.100930712558287 0.00870229316842184 21874046;26883911;20406109;21537871 Additionally the activation of thyroid most common oncogenes RET/PTC3 and BRAF in PCCL3 cells upregulated miR-146b-5p expression;miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells independently from their original mutation either BRAF or RET/PTC through a mechanism that involves the actin cytoskeleton but not an increased capacity of matrix degradation;The miR-146b expression levels in PTCs with BRAF mutation were significantly higher than those without this mutation p < 0.0001;Among BRAF-positive tumors overexpression of miR-146b was associated with aggressive behavior suggesting that it may further refine the prognostic importance of BRAF ;;; thyroid cancer;thyroid cancer;thyroid cancer;thyroid cancer hsa-miR-130b-5p CACNA1A 3.74118449312296 2.92266550966038e-10 -2.04076955117269 0.0387855296177451 mirMAP -0.280111053758968 0.0022947047655869 NA NA NA hsa-miR-2355-3p CACNA1A 0.494099635633886 0.483724014019781 -2.04076955117269 0.0387855296177451 MirTarget;miRNATAP -0.286359501440622 0.000313003586090036 NA NA NA hsa-miR-629-3p CACNA1A 3.48282157979573 4.9176538695908e-08 -2.04076955117269 0.0387855296177451 MirTarget;miRNATAP -0.261195555868572 0.00238269881764243 NA NA NA hsa-let-7a-3p CACNA1C 0.82512001802525 0.0468122405194487 -5.47617607166292 9.14588480929742e-11 MirTarget -0.619188972061656 1.79808634708146e-07 NA NA NA hsa-let-7b-3p CACNA1C 0.589364128513318 0.200507534602851 -5.47617607166292 9.14588480929742e-11 MirTarget -0.443337392722613 3.82741180878419e-05 NA NA NA hsa-let-7f-1-3p CACNA1C 1.61507869803314 0.00069342464777815 -5.47617607166292 9.14588480929742e-11 MirTarget -0.652008359950811 1.43751813692486e-10 NA NA NA hsa-miR-107 CACNA1C 1.49443409571439 0.000130594521065411 -5.47617607166292 9.14588480929742e-11 miRNATAP -0.453902872239309 0.000340382506848196 NA NA NA hsa-miR-1271-5p CACNA1C 0.212382644103427 0.742544160267329 -5.47617607166292 9.14588480929742e-11 MirTarget -0.20657603862512 0.00724010707726398 NA NA NA hsa-miR-148b-5p CACNA1C 2.80812018666078 3.97536665756679e-08 -5.47617607166292 9.14588480929742e-11 mirMAP -0.488270851368408 1.95335677170735e-07 NA NA NA hsa-miR-149-5p CACNA1C 1.18551753240939 0.197439607622379 -5.47617607166292 9.14588480929742e-11 MirTarget -0.181267489660474 0.000706603218901052 NA NA NA hsa-miR-1976 CACNA1C 3.27217274919653 3.16337235854532e-12 -5.47617607166292 9.14588480929742e-11 MirTarget -0.538305824522347 8.83631740820084e-08 NA NA NA hsa-miR-19a-3p CACNA1C 2.17020503944519 0.00122084653711062 -5.47617607166292 9.14588480929742e-11 MirTarget -0.282900033315771 0.00010336560889601 NA NA NA hsa-miR-19b-1-5p CACNA1C 1.51335451095424 0.0014717605268143 -5.47617607166292 9.14588480929742e-11 MirTarget -0.77551349476945 7.92142211275159e-15 NA NA NA hsa-miR-19b-3p CACNA1C 1.67581705793313 0.000858910586302716 -5.47617607166292 9.14588480929742e-11 MirTarget -0.473007590548559 1.09593830882506e-06 NA NA NA hsa-miR-200b-3p CACNA1C 5.56167217794639 6.43540045061709e-16 -5.47617607166292 9.14588480929742e-11 MirTarget;TargetScan -0.333728594581851 7.59065015614495e-07 NA NA NA hsa-miR-200c-3p CACNA1C 6.47012025883743 2.64500707716408e-26 -5.47617607166292 9.14588480929742e-11 MirTarget -0.479623033848176 3.52519696145397e-11 NA NA NA hsa-miR-320b CACNA1C 0.20205459771295 0.727216419960509 -5.47617607166292 9.14588480929742e-11 miRNATAP -0.234381000372296 0.0063392189495721 NA NA NA hsa-miR-330-5p CACNA1C 2.25110496739954 0.000275527655397415 -5.47617607166292 9.14588480929742e-11 miRanda -0.376711785043232 1.55638371457174e-06 NA NA NA hsa-miR-33a-5p CACNA1C 2.60046838991599 0.000472459723448608 -5.47617607166292 9.14588480929742e-11 MirTarget -0.421391022919296 4.86476103153023e-11 NA NA NA hsa-miR-33b-5p CACNA1C 4.77891217497671 1.33695107675057e-08 -5.47617607166292 9.14588480929742e-11 MirTarget -0.426631356970067 1.13947139342401e-14 NA NA NA hsa-miR-342-3p CACNA1C 1.31107714473009 0.0207211910724662 -5.47617607166292 9.14588480929742e-11 MirTarget;PITA;miRanda;miRNATAP -0.286228021323273 0.00102522991746093 NA NA NA hsa-miR-361-3p CACNA1C 0.805698609170807 0.0418491665498322 -5.47617607166292 9.14588480929742e-11 MirTarget -0.416085571445733 0.000981284871397424 NA NA NA hsa-miR-378a-5p CACNA1C 1.25775140086104 0.0500877723587615 -5.47617607166292 9.14588480929742e-11 MirTarget -0.363153220065397 1.85419092746323e-06 NA NA NA hsa-miR-3922-3p CACNA1C 2.5745007343008 8.26367348669111e-05 -5.47617607166292 9.14588480929742e-11 mirMAP;miRNATAP -0.233931296734716 0.00233020714759866 NA NA NA hsa-miR-421 CACNA1C 1.97624148591545 0.000915838012451138 -5.47617607166292 9.14588480929742e-11 MirTarget;PITA;miRanda;miRNATAP -0.343821542421807 2.91336059432039e-05 NA NA NA hsa-miR-429 CACNA1C 6.39965293994036 1.96920201593608e-18 -5.47617607166292 9.14588480929742e-11 MirTarget;PITA;miRanda;miRNATAP -0.327034443924629 1.93657166291212e-07 NA NA NA hsa-miR-484 CACNA1C 1.79050445056016 0.000217287101253701 -5.47617607166292 9.14588480929742e-11 PITA;miRNATAP -0.405495202630408 6.2602041238465e-05 NA NA NA hsa-miR-589-3p CACNA1C 1.33205316880069 0.052632683806148 -5.47617607166292 9.14588480929742e-11 MirTarget;mirMAP -0.225369700369705 0.00182160354378384 NA NA NA hsa-miR-671-3p CACNA1C 0.847529330979345 0.144049617572037 -5.47617607166292 9.14588480929742e-11 miRNATAP -0.223763634959584 0.00943683149049715 NA NA NA hsa-miR-7-1-3p CACNA1C 1.43074343339835 0.00471215970502094 -5.47617607166292 9.14588480929742e-11 MirTarget -0.402542927968496 3.40837220316574e-05 NA NA NA hsa-miR-877-5p CACNA1C 3.67317721493893 4.85916829184578e-06 -5.47617607166292 9.14588480929742e-11 MirTarget -0.28328671646562 2.89303538597666e-06 NA NA NA hsa-miR-93-3p CACNA1C 2.62833115374128 2.28843227834337e-07 -5.47617607166292 9.14588480929742e-11 mirMAP -0.561807823995434 2.20403961673837e-09 NA NA NA hsa-miR-944 CACNA1C 7.20925181386398 0.000823207457340648 -5.47617607166292 9.14588480929742e-11 mirMAP -0.190696334666921 3.13609971843423e-12 NA NA NA hsa-miR-96-5p CACNA1C 5.62521466029286 1.54938806718028e-10 -5.47617607166292 9.14588480929742e-11 MirTarget;TargetScan -0.282533865899209 2.01107365702855e-05 NA NA NA hsa-let-7a-2-3p CACNA1D -0.473187184280926 0.602054994636968 -1.70638438833493 0.237432799344119 MirTarget -0.276191904392386 0.00261002500936261 NA NA NA hsa-miR-142-3p CACNA1D 4.35304505457969 3.10014573651358e-10 -1.70638438833493 0.237432799344119 miRanda -0.354958814853809 0.00198887781214085 NA NA NA hsa-miR-144-3p CACNA1D 2.05914250670468 0.0977571657256429 -1.70638438833493 0.237432799344119 miRNATAP -0.173946076739304 0.00832524160321028 NA NA NA hsa-miR-17-3p CACNA1D 1.2477858204856 0.00186593270231258 -1.70638438833493 0.237432799344119 MirTarget;miRNATAP -0.594108045578376 0.00386608006150961 NA NA NA hsa-miR-330-5p CACNA1D 2.25110496739954 0.000275527655397415 -1.70638438833493 0.237432799344119 miRanda -0.787400322108828 8.42733444828799e-10 NA NA NA hsa-miR-342-3p CACNA1D 1.31107714473009 0.0207211910724662 -1.70638438833493 0.237432799344119 miRanda -0.690529262446826 1.33860584019995e-06 NA NA NA hsa-miR-582-5p CACNA1D 0.685177900016753 0.447761540297692 -1.70638438833493 0.237432799344119 miRNATAP -0.268473233889069 0.00303786051476425 NA NA NA hsa-miR-590-3p CACNA1D 2.35429565068338 2.79601879608564e-06 -1.70638438833493 0.237432799344119 miRanda;miRNATAP -0.606625597734197 0.000158330062509921 NA NA NA hsa-miR-629-5p CACNA1D 1.57164125641392 0.0115716388531198 -1.70638438833493 0.237432799344119 MirTarget -0.523177161224697 6.1155066601879e-05 NA NA NA hsa-let-7a-5p CACNA1E 0.148081801547773 0.645305441523746 1.17850812707877 0.355475715981356 TargetScan;miRNATAP -0.709421383413988 0.00208695274791852 NA NA NA hsa-miR-17-3p CACNA1E 1.2477858204856 0.00186593270231258 1.17850812707877 0.355475715981356 miRNATAP -0.529385231472731 0.00353354219187718 NA NA NA hsa-miR-205-5p CACNA1E 8.08298115900323 3.83045179398654e-07 1.17850812707877 0.355475715981356 mirMAP -0.164762611868408 0.000188108281548536 NA NA NA hsa-miR-92a-1-5p CACNA1E 2.14839829606717 0.0015466735813532 1.17850812707877 0.355475715981356 mirMAP -0.274422933742613 0.00975588245314347 NA NA NA hsa-miR-944 CACNA1E 7.20925181386398 0.000823207457340648 1.17850812707877 0.355475715981356 mirMAP -0.201071755805729 8.0392565724497e-07 NA NA NA hsa-miR-151a-3p CACNA1G 0.373902859770645 0.376924505912903 -3.47648841281308 0.000523691438489887 MirTarget -0.413868524115997 0.00252777372940723 NA NA NA hsa-miR-3651 CACNA1G 2.43541496300639 0.0980878637833684 -3.47648841281308 0.000523691438489887 MirTarget -0.258090892984403 0.000144249811972302 NA NA NA hsa-miR-590-5p CACNA1G 1.51400888103768 0.0023888567923017 -3.47648841281308 0.000523691438489887 miRanda -0.395675258728576 0.000560318616765483 NA NA NA hsa-miR-629-3p CACNA1G 3.48282157979573 4.9176538695908e-08 -3.47648841281308 0.000523691438489887 MirTarget -0.435216249371951 5.15873361055772e-07 NA NA NA hsa-miR-96-5p CACNA1G 5.62521466029286 1.54938806718028e-10 -3.47648841281308 0.000523691438489887 TargetScan -0.329301359382543 1.78080262599936e-05 NA NA NA hsa-miR-32-5p CACNA1H 2.93035124381469 5.00149131394151e-10 -5.97293921556009 5.87570339443244e-10 miRNATAP -0.507602602578996 1.18656794986452e-05 NA NA NA hsa-miR-361-3p CACNA1H 0.805698609170807 0.0418491665498322 -5.97293921556009 5.87570339443244e-10 MirTarget;mirMAP -0.430753158720883 0.00276042623523434 NA NA NA hsa-miR-92a-3p CACNA1H 1.87892405805529 1.27013821556583e-05 -5.97293921556009 5.87570339443244e-10 miRNATAP -0.729637181243638 1.1585058741886e-08 NA NA NA hsa-miR-130a-5p CACNA2D1 1.58028512890005 0.024346333013728 -0.900900006170782 0.611649328760661 mirMAP -0.441073188730586 0.00241876564484987 NA NA NA hsa-miR-141-3p CACNA2D1 7.30474126597325 1.45115996357606e-24 -0.900900006170782 0.611649328760661 TargetScan -0.363488069496372 0.00513880661666856 NA NA NA hsa-miR-182-5p CACNA2D1 5.86988712704738 1.22411588571584e-15 -0.900900006170782 0.611649328760661 miRNATAP -0.346593929257225 0.00791959644068174 NA NA NA hsa-miR-21-3p CACNA2D1 3.50297439576639 6.39946844099206e-10 -0.900900006170782 0.611649328760661 mirMAP -0.512935329994974 0.00299340849141089 NA NA NA hsa-miR-26b-5p CACNA2D1 0.314414148564179 0.461628303578321 -0.900900006170782 0.611649328760661 mirMAP -0.706474320379141 0.0030221357053719 NA NA NA hsa-miR-30d-3p CACNA2D1 -0.0740421896025512 0.857423650167556 -0.900900006170782 0.611649328760661 mirMAP -0.685176909214083 0.00564130713793692 NA NA NA hsa-miR-335-3p CACNA2D1 1.19503568251824 0.0938852560631551 -0.900900006170782 0.611649328760661 mirMAP -0.424062385837229 0.00258372484171182 NA NA NA hsa-miR-338-3p CACNA2D1 0.447551118940466 0.558485097370031 -0.900900006170782 0.611649328760661 miRanda -0.47798628341111 0.000261858165052294 NA NA NA hsa-miR-362-3p CACNA2D1 0.679952485897744 0.226148468488576 -0.900900006170782 0.611649328760661 miRanda -0.636536197168932 0.000395822893753959 NA NA NA hsa-miR-590-3p CACNA2D1 2.35429565068338 2.79601879608564e-06 -0.900900006170782 0.611649328760661 mirMAP -0.565413792079044 0.00431512364734167 NA NA NA hsa-miR-142-3p CACNA2D2 4.35304505457969 3.10014573651358e-10 -2.24895893479147 0.00644760156495969 miRanda -0.194072852652806 0.00325107929847493 NA NA NA hsa-miR-193a-3p CACNA2D2 0.646392169474854 0.207134343676122 -2.24895893479147 0.00644760156495969 miRanda -0.346071877008909 0.00016510829708152 NA NA NA hsa-miR-205-5p CACNA2D2 8.08298115900323 3.83045179398654e-07 -2.24895893479147 0.00644760156495969 miRNATAP -0.194558985140159 3.13399937888547e-12 NA NA NA hsa-miR-22-5p CACNA2D2 2.38337850108621 1.0773503998394e-05 -2.24895893479147 0.00644760156495969 mirMAP -0.348629212378626 4.45196441221013e-05 NA NA NA hsa-miR-3614-5p CACNA2D2 4.50236405439456 2.75644515847367e-07 -2.24895893479147 0.00644760156495969 mirMAP -0.231988499495184 9.05382955354198e-06 NA NA NA hsa-miR-18a-3p CACNA2D3 3.64944956993027 7.20156641833731e-07 -0.232618166403156 0.863295124947716 miRNAWalker2_validate -0.327150098647726 0.00141069639111689 NA NA NA hsa-miR-324-5p CACNA2D4 1.31253452379847 0.0116806680545163 -0.440083702916022 0.397594100830547 miRanda -0.265891039465873 2.02859225785348e-06 NA NA NA hsa-miR-335-3p CACNA2D4 1.19503568251824 0.0938852560631551 -0.440083702916022 0.397594100830547 mirMAP -0.130396389202652 0.0015294476508517 NA NA NA hsa-miR-339-5p CACNA2D4 1.23326828594484 0.0307501214818698 -0.440083702916022 0.397594100830547 miRanda -0.161725597393036 0.00169739337059396 NA NA NA hsa-miR-429 CACNA2D4 6.39965293994036 1.96920201593608e-18 -0.440083702916022 0.397594100830547 miRanda -0.176537522243245 2.51858667042982e-06 NA NA NA hsa-miR-24-3p CACNB1 1.55853749533999 0.000524726461381821 -0.668712382224456 0.30330557595016 miRNATAP -0.457878331060923 1.20875545437261e-08 NA NA NA hsa-let-7a-3p CACNB2 0.82512001802525 0.0468122405194487 -5.63641791033719 9.0677293373113e-17 MirTarget;mirMAP -0.321905318940635 0.00107914681843092 NA NA NA hsa-let-7b-3p CACNB2 0.589364128513318 0.200507534602851 -5.63641791033719 9.0677293373113e-17 MirTarget;mirMAP -0.311207239447087 0.00043773110868951 NA NA NA hsa-let-7f-1-3p CACNB2 1.61507869803314 0.00069342464777815 -5.63641791033719 9.0677293373113e-17 MirTarget;mirMAP -0.408947444179877 1.28925029137801e-06 NA NA NA hsa-miR-130a-5p CACNB2 1.58028512890005 0.024346333013728 -5.63641791033719 9.0677293373113e-17 mirMAP -0.168747177836467 0.00400970130417526 NA NA NA hsa-miR-16-5p CACNB2 2.93575808220754 2.15436817162977e-10 -5.63641791033719 9.0677293373113e-17 miRNAWalker2_validate -0.543001328333754 7.29105020580312e-11 NA NA NA hsa-miR-182-5p CACNB2 5.86988712704738 1.22411588571584e-15 -5.63641791033719 9.0677293373113e-17 miRNATAP -0.291277090316328 1.60714533242345e-08 NA NA NA hsa-miR-200c-5p CACNB2 5.34093243595571 3.35355119348069e-10 -5.63641791033719 9.0677293373113e-17 MirTarget;miRNATAP -0.306174384215513 3.74265484728244e-08 NA NA NA hsa-miR-23a-3p CACNB2 0.925125296618358 0.0127293543936914 -5.63641791033719 9.0677293373113e-17 mirMAP -0.403756059359049 0.000246165410793433 NA NA NA hsa-miR-27a-3p CACNB2 1.76094007417453 0.000216137556256765 -5.63641791033719 9.0677293373113e-17 MirTarget;miRNATAP -0.338676397510837 6.03001047071418e-05 NA NA NA hsa-miR-31-5p CACNB2 7.15600983164746 6.64190917357724e-10 -5.63641791033719 9.0677293373113e-17 MirTarget;miRNATAP -0.16961504691428 3.67107791215862e-07 NA NA NA hsa-miR-339-5p CACNB2 1.23326828594484 0.0307501214818698 -5.63641791033719 9.0677293373113e-17 miRNATAP -0.247679919039169 0.000470910524405399 NA NA NA hsa-miR-3653-3p CACNB2 2.32416512605984 0.000268136992079666 -5.63641791033719 9.0677293373113e-17 MirTarget -0.271263258567094 1.47338414417873e-05 NA NA NA hsa-miR-429 CACNB2 6.39965293994036 1.96920201593608e-18 -5.63641791033719 9.0677293373113e-17 PITA;miRanda;miRNATAP -0.28919418737693 1.68258996657221e-08 NA NA NA hsa-miR-550a-3p CACNB2 2.59872127213466 0.00155498164206068 -5.63641791033719 9.0677293373113e-17 MirTarget;miRNATAP -0.209212724564114 0.000486107896892603 NA NA NA hsa-miR-590-3p CACNB2 2.35429565068338 2.79601879608564e-06 -5.63641791033719 9.0677293373113e-17 mirMAP -0.240557972071174 0.00256638291000729 NA NA NA hsa-miR-93-3p CACNB2 2.62833115374128 2.28843227834337e-07 -5.63641791033719 9.0677293373113e-17 MirTarget;miRNATAP -0.261146440944668 0.000873708185786638 NA NA NA hsa-miR-96-5p CACNB2 5.62521466029286 1.54938806718028e-10 -5.63641791033719 9.0677293373113e-17 miRNATAP -0.193570047709297 0.000384168953828891 NA NA NA hsa-miR-361-3p CACNB3 0.805698609170807 0.0418491665498322 -0.860372397843889 0.0283269552221822 mirMAP -0.213509901752216 0.00015934211552218 NA NA NA hsa-miR-629-3p CACNB3 3.48282157979573 4.9176538695908e-08 -0.860372397843889 0.0283269552221822 miRNATAP -0.115840350416702 0.000652226603298727 NA NA NA hsa-miR-142-5p CACNB4 3.95552531913424 1.49536283724079e-08 -1.43375666922255 0.136472275667574 mirMAP -0.268598169952146 0.000413243662007743 NA NA NA hsa-miR-155-5p CACNB4 2.81443182173772 7.42530504828797e-05 -1.43375666922255 0.136472275667574 mirMAP;miRNATAP -0.317221603737285 2.62105818295309e-05 NA NA NA hsa-miR-20a-3p CACNB4 1.9920766549842 0.000624458530894697 -1.43375666922255 0.136472275667574 miRNATAP -0.243278848676018 0.00922224930975673 NA NA NA hsa-miR-221-3p CACNB4 0.94082283577318 0.174749164179978 -1.43375666922255 0.136472275667574 miRNATAP -0.38190310121675 9.16778694863438e-07 NA NA NA hsa-miR-222-3p CACNB4 1.54730827524553 0.0223014220569407 -1.43375666922255 0.136472275667574 miRNATAP -0.400578489509716 4.50023226134613e-07 NA NA NA hsa-miR-223-5p CACNB4 0.959759165222839 0.234618118905303 -1.43375666922255 0.136472275667574 mirMAP -0.218383063725786 0.00134618354062027 NA NA NA hsa-miR-29b-1-5p CACNB4 0.33698032160171 0.598092174563471 -1.43375666922255 0.136472275667574 mirMAP -0.279159184634342 0.00116022630111836 NA NA NA hsa-miR-330-3p CACNB4 2.49094236945806 0.000129367003214715 -1.43375666922255 0.136472275667574 mirMAP -0.34871652041911 2.52898411566758e-05 NA NA NA hsa-miR-342-3p CACNB4 1.31107714473009 0.0207211910724662 -1.43375666922255 0.136472275667574 miRanda -0.269632227206406 0.00518583171845792 NA NA NA hsa-miR-34c-3p CACNB4 4.0411891981675 0.000195495966405666 -1.43375666922255 0.136472275667574 mirMAP -0.145302823735312 0.00365105874857319 NA NA NA hsa-miR-424-5p CACNB4 0.209571188331903 0.753714747345068 -1.43375666922255 0.136472275667574 miRNATAP -0.213368813573299 0.00930556331451505 NA NA NA hsa-miR-944 CACNB4 7.20925181386398 0.000823207457340648 -1.43375666922255 0.136472275667574 PITA;mirMAP -0.144456953976942 2.82729502744801e-06 NA NA NA hsa-let-7b-3p CACNG4 0.589364128513318 0.200507534602851 2.17245160443533 0.238360655107077 MirTarget -0.641090326476763 0.00513528558653908 NA NA NA hsa-miR-3614-5p CACNG4 4.50236405439456 2.75644515847367e-07 2.17245160443533 0.238360655107077 mirMAP -0.367534219690831 0.00169725643976482 NA NA NA hsa-miR-582-5p CHP2 0.685177900016753 0.447761540297692 1.48109800587141 0.509563690322669 miRNATAP -0.415938249783453 0.0031281915626761 NA NA NA hsa-miR-374b-5p CRK -0.114749866169918 0.764888930049438 -0.176148864122969 0.63506886373607 mirMAP -0.176539566373988 0.00143885548119382 NA NA NA hsa-miR-590-3p CRK 2.35429565068338 2.79601879608564e-06 -0.176148864122969 0.63506886373607 mirMAP -0.128427311380145 0.00181840046282391 NA NA NA hsa-miR-181c-5p CRKL -0.302833440762172 0.537532549455539 0.368072442063563 0.274625892989609 mirMAP -0.126090454606492 0.0011940314919042 NA NA NA hsa-miR-29a-5p CRKL 0.0748295222568571 0.884125894063293 0.368072442063563 0.274625892989609 MirTarget -0.101949042879655 0.0062516458849693 NA NA NA hsa-miR-30a-5p CRKL -0.768430903969183 0.320487552854215 0.368072442063563 0.274625892989609 MirTarget;mirMAP;miRNATAP -0.155398090332267 7.67939321330036e-11 NA NA NA hsa-miR-141-3p DUSP1 7.30474126597325 1.45115996357606e-24 -2.32150271759423 0.0116270325712639 TargetScan -0.202937260195607 0.00267520474532396 NA NA NA hsa-miR-200b-3p DUSP1 5.56167217794639 6.43540045061709e-16 -2.32150271759423 0.0116270325712639 MirTarget;TargetScan -0.27097800404229 0.000167798828015549 NA NA NA hsa-miR-429 DUSP1 6.39965293994036 1.96920201593608e-18 -2.32150271759423 0.0116270325712639 MirTarget;PITA;miRanda;miRNATAP -0.236411009103877 0.000442091109392727 NA NA NA hsa-miR-362-3p DUSP10 0.679952485897744 0.226148468488576 1.13544519848268 0.0680966504280805 MirTarget;PITA;miRanda;miRNATAP -0.166112779929679 0.00875824296112562 NA NA NA hsa-miR-224-3p DUSP16 2.84876340814503 0.000179138399939161 -0.551206986816646 0.177876721406396 MirTarget -0.110405580429195 0.000256773886912091 NA NA NA hsa-miR-28-5p DUSP22 -0.815636722979196 0.0221199948901761 -0.674453670071212 0.0550541480812575 miRanda -0.191058198967978 0.000722880919014317 NA NA NA hsa-miR-30e-3p DUSP3 -0.0362193022195196 0.932577027239525 -1.07734997121079 6.19279714358772e-05 mirMAP -0.104560711611986 0.00385493716095249 NA NA NA hsa-miR-3913-5p DUSP3 0.145645056779437 0.734844256690741 -1.07734997121079 6.19279714358772e-05 MirTarget -0.110902281226484 0.00205318767807493 NA NA NA hsa-miR-205-5p DUSP4 8.08298115900323 3.83045179398654e-07 0.90773071020576 0.406345782907748 mirMAP -0.252145222330723 7.47621701424658e-12 NA NA NA hsa-miR-23b-3p DUSP4 -0.581135273821923 0.190478897170459 0.90773071020576 0.406345782907748 mirMAP -0.802075682992553 6.30417214442999e-09 NA NA NA hsa-miR-452-5p DUSP4 2.45466810475361 0.00114794259949532 0.90773071020576 0.406345782907748 mirMAP -0.35095079795746 1.37348452736641e-05 NA NA NA hsa-miR-9-3p DUSP4 1.69328215716742 0.125170982657059 0.90773071020576 0.406345782907748 mirMAP -0.22927251639881 4.81726338295097e-05 NA NA NA hsa-miR-944 DUSP4 7.20925181386398 0.000823207457340648 0.90773071020576 0.406345782907748 mirMAP -0.283230740225499 3.86873404194579e-17 NA NA NA hsa-miR-363-3p DUSP5 4.27232887548977 8.53979362839458e-06 -0.16627701040995 0.839412153890648 MirTarget -0.178954111029933 0.000160103190471219 NA NA NA hsa-miR-429 DUSP5 6.39965293994036 1.96920201593608e-18 -0.16627701040995 0.839412153890648 miRNATAP -0.168847664159274 0.00482114404578407 NA NA NA hsa-miR-342-3p DUSP6 1.31107714473009 0.0207211910724662 -0.70448136327582 0.389528318754477 PITA;miRanda -0.275037066600246 0.000757388194479063 NA NA NA hsa-miR-107 DUSP7 1.49443409571439 0.000130594521065411 0.941325036101027 0.222553851723417 miRanda -0.374093765788064 0.00085042442591112 NA NA NA hsa-miR-10a-5p DUSP7 -0.482300926520507 0.594608783320466 0.941325036101027 0.222553851723417 mirMAP -0.431613648135373 1.09078010466574e-21 NA NA NA hsa-miR-125a-5p DUSP7 -1.32352790615388 0.00714301627309467 0.941325036101027 0.222553851723417 miRanda -0.550030153827818 2.39854750717722e-10 NA NA NA hsa-miR-129-5p DUSP7 -2.66843722411409 0.00695783358331245 0.941325036101027 0.222553851723417 miRanda -0.148572186742107 0.000846104490523638 NA NA NA hsa-miR-186-5p DUSP7 0.445443449112564 0.185447310527704 0.941325036101027 0.222553851723417 mirMAP -0.527938123343779 6.44589763376024e-05 NA NA NA hsa-miR-200b-3p DUSP7 5.56167217794639 6.43540045061709e-16 0.941325036101027 0.222553851723417 TargetScan -0.275840517529102 3.96982637898899e-06 NA NA NA hsa-miR-3200-3p DUSP7 2.3251191657063 0.0140310042534957 0.941325036101027 0.222553851723417 mirMAP -0.305078241580889 1.18333077750993e-11 NA NA NA hsa-miR-335-5p DUSP7 0.167216045757305 0.803897055331049 0.941325036101027 0.222553851723417 mirMAP -0.274470082991876 2.1244643882881e-05 NA NA NA hsa-miR-345-5p DUSP7 2.77314563304336 4.34343702412489e-05 0.941325036101027 0.222553851723417 mirMAP -0.369462365415144 3.15593471507001e-09 NA NA NA hsa-miR-362-5p DUSP7 -1.22309034685697 0.0452665543907975 0.941325036101027 0.222553851723417 mirMAP -0.291547527169184 4.14582459713183e-05 NA NA NA hsa-miR-429 DUSP7 6.39965293994036 1.96920201593608e-18 0.941325036101027 0.222553851723417 miRanda;miRNATAP -0.236079334903435 2.44768752303538e-05 NA NA NA hsa-miR-532-3p DUSP7 0.643755490841218 0.214842585969913 0.941325036101027 0.222553851723417 mirMAP -0.362282875845217 1.62652057600133e-05 NA NA NA hsa-miR-625-5p DUSP7 2.02792641909347 0.000935142379948297 0.941325036101027 0.222553851723417 mirMAP -0.282346273082338 7.21582924832149e-05 NA NA NA hsa-miR-1976 DUSP8 3.27217274919653 3.16337235854532e-12 -1.69759743607935 0.0131701427362937 MirTarget -0.26014691982576 0.00120772271528714 NA NA NA hsa-miR-21-5p DUSP8 2.65163477806992 6.72089787690756e-16 -1.69759743607935 0.0131701427362937 miRNAWalker2_validate;MirTarget -0.409307389673946 0.000362711577974833 NA NA NA hsa-miR-24-3p DUSP8 1.55853749533999 0.000524726461381821 -1.69759743607935 0.0131701427362937 MirTarget;miRNATAP -0.275691191041294 0.00145601882280532 NA NA NA hsa-miR-31-5p DUSP8 7.15600983164746 6.64190917357724e-10 -1.69759743607935 0.0131701427362937 mirMAP -0.125690696321445 0.000101192484280127 NA NA NA hsa-miR-342-5p DUSP8 1.3865615438184 0.0153598969109545 -1.69759743607935 0.0131701427362937 mirMAP -0.181585934109077 0.00769768743358423 NA NA NA hsa-miR-3922-3p DUSP8 2.5745007343008 8.26367348669111e-05 -1.69759743607935 0.0131701427362937 mirMAP -0.18915723110165 0.00175100947778749 NA NA NA hsa-miR-194-5p DUSP9 0.691219038144468 0.523143086635506 6.66211743900964 3.77572698642381e-05 MirTarget;miRNATAP -0.533071443833546 1.58714208108198e-10 NA NA NA hsa-miR-99a-5p DUSP9 -2.72139054000803 0.00621971944534118 6.66211743900964 3.77572698642381e-05 mirMAP -0.263227595668982 0.00449400365998385 NA NA NA hsa-miR-125a-5p EGFR -1.32352790615388 0.00714301627309467 1.4001245301835 0.170261817468909 mirMAP -0.42322860924045 0.000316823060379402 19881956;27094723;24484870 We report that EGFR signaling leads to transcriptional repression of the miRNA miR-125a through the ETS family transcription factor PEA3;Suppression of microRNA 125a 5p upregulates the TAZ EGFR signaling pathway and promotes retinoblastoma proliferation; Moreover the overexpression of miR-125a-5p led to a decrease in TAZ expression and downstream EGFR signaling pathway activation both in vitro and vivo; Finally TAZ overexpression in retinoblastoma cells overexpressing miR-125a-5p restored retinoblastoma cell proliferation and EGFR pathway activation; Taken together our data demonstrated that miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma;miR 125a regulates cell cycle proliferation and apoptosis by targeting the ErbB pathway in acute myeloid leukemia; Profiling revealed the ErbB pathway as significantly decreased with ectopic miR-125a; Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic agents for treating miR-125a-low AML ;progression;progression ovarian cancer;retinoblastoma;acute myeloid leukemia hsa-miR-128-3p EGFR 1.36248409467631 0.00408435995818078 1.4001245301835 0.170261817468909 miRNAWalker2_validate;miRTarBase -0.325270996219395 0.00791157440942446 NA NA NA hsa-miR-148b-5p EGFR 2.80812018666078 3.97536665756679e-08 1.4001245301835 0.170261817468909 mirMAP -0.287810299143976 0.00993634422968525 NA NA NA hsa-miR-186-5p EGFR 0.445443449112564 0.185447310527704 1.4001245301835 0.170261817468909 mirMAP -0.72926872723882 2.99701181181913e-05 NA NA NA hsa-miR-188-5p EGFR 1.39111178824125 0.0251592818948912 1.4001245301835 0.170261817468909 mirMAP -0.263000006285575 0.00496388298567065 NA NA NA hsa-miR-192-3p EGFR 0.84572845432662 0.480940346018965 1.4001245301835 0.170261817468909 mirMAP -0.19627166733635 5.85182501324464e-05 NA NA NA hsa-miR-192-5p EGFR 1.77716187978541 0.113485496183047 1.4001245301835 0.170261817468909 mirMAP -0.254778390974915 4.87299611634051e-07 NA NA NA hsa-miR-194-3p EGFR 1.91743783341496 0.105383373371284 1.4001245301835 0.170261817468909 MirTarget -0.18150332146796 0.000207666578228104 NA NA NA hsa-miR-200a-3p EGFR 6.336081120041 4.024313571871e-16 1.4001245301835 0.170261817468909 MirTarget -0.314197934364205 6.96888933660157e-06 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-26b-3p EGFR 0.985177548213122 0.0351427970185971 1.4001245301835 0.170261817468909 mirMAP -0.334456182236821 0.00731279830838523 NA NA NA hsa-miR-29b-2-5p EGFR -0.596051745078872 0.189540844841389 1.4001245301835 0.170261817468909 mirMAP -0.650549075574319 2.87046383123889e-07 NA NA NA hsa-miR-30a-3p EGFR -1.22212086897848 0.167565797592104 1.4001245301835 0.170261817468909 mirMAP -0.214317153681821 0.000993490591329179 NA NA NA hsa-miR-30a-5p EGFR -0.768430903969183 0.320487552854215 1.4001245301835 0.170261817468909 miRNAWalker2_validate -0.276326861755088 0.000207968085523555 NA NA NA hsa-miR-362-5p EGFR -1.22309034685697 0.0452665543907975 1.4001245301835 0.170261817468909 mirMAP -0.429041522813014 4.85211172370353e-06 NA NA NA hsa-miR-375 EGFR 3.3784490463318 0.0449946294355695 1.4001245301835 0.170261817468909 miRanda -0.222319476304576 1.9252452765405e-11 NA NA NA hsa-miR-7-1-3p EGFR 1.43074343339835 0.00471215970502094 1.4001245301835 0.170261817468909 mirMAP -0.478554115110538 2.53296595691169e-05 NA NA NA hsa-miR-29a-5p ELK4 0.0748295222568571 0.884125894063293 1.59447784305808 6.80656577635915e-05 mirMAP -0.127007284426553 0.00467017703295382 NA NA NA hsa-miR-365a-3p ELK4 0.25545896241765 0.654320504621012 1.59447784305808 6.80656577635915e-05 mirMAP -0.104955157854768 0.0092827686917122 NA NA NA hsa-miR-106a-5p FAS 3.98693608217557 9.37722470816656e-07 -0.344841531633832 0.589341195024639 miRNAWalker2_validate;miRTarBase -0.140227807754695 0.00127753821199214 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-361-5p FAS 0.00649167180664723 0.985202350239079 -0.344841531633832 0.589341195024639 miRanda -0.330419186265804 0.00171930259182594 NA NA NA hsa-miR-590-5p FAS 1.51400888103768 0.0023888567923017 -0.344841531633832 0.589341195024639 miRanda -0.19807034795777 0.00636164081342142 NA NA NA hsa-miR-199a-5p FASLG -1.24888110793613 0.0747755616523728 1.92790162472903 0.0908475849274605 miRanda -0.398497989415625 1.31601874419318e-05 NA NA NA hsa-miR-28-5p FASLG -0.815636722979196 0.0221199948901761 1.92790162472903 0.0908475849274605 miRanda -0.57816364875664 0.00170836414115334 NA NA NA hsa-miR-324-5p FASLG 1.31253452379847 0.0116806680545163 1.92790162472903 0.0908475849274605 miRanda -0.332106354222357 0.00772738622468345 NA NA NA hsa-miR-92b-3p FASLG 1.69303761469782 0.0103484911955574 1.92790162472903 0.0908475849274605 miRNATAP -0.252529060131383 0.00986337973635399 NA NA NA hsa-miR-186-5p FGF1 0.445443449112564 0.185447310527704 -0.904800782358151 0.37514033641596 mirMAP -0.498564513948469 0.00456225800988677 NA NA NA hsa-miR-18a-5p FGF1 3.90770175770219 9.15298615034137e-10 -0.904800782358151 0.37514033641596 MirTarget -0.41163099594303 2.32644463832958e-06 NA NA NA hsa-miR-330-5p FGF1 2.25110496739954 0.000275527655397415 -0.904800782358151 0.37514033641596 miRanda;miRNATAP -0.300815609641433 0.00115338039105615 NA NA NA hsa-miR-429 FGF1 6.39965293994036 1.96920201593608e-18 -0.904800782358151 0.37514033641596 miRNATAP -0.277552339482351 0.000183037961286987 NA NA NA hsa-miR-484 FGF1 1.79050445056016 0.000217287101253701 -0.904800782358151 0.37514033641596 MirTarget;PITA;miRNATAP -0.634998887940648 5.85563813084433e-08 NA NA NA hsa-miR-532-3p FGF1 0.643755490841218 0.214842585969913 -0.904800782358151 0.37514033641596 miRNATAP -0.387150102032302 0.000527239876040661 NA NA NA hsa-miR-550a-5p FGF1 1.21781238856895 0.0613791144699551 -0.904800782358151 0.37514033641596 MirTarget -0.314103791160951 0.000393501674872474 NA NA NA hsa-miR-576-5p FGF1 1.30320223793746 0.00648929463912994 -0.904800782358151 0.37514033641596 PITA;mirMAP -0.327654055057913 0.00686443176136871 NA NA NA hsa-miR-590-5p FGF1 1.51400888103768 0.0023888567923017 -0.904800782358151 0.37514033641596 MirTarget;miRanda;miRNATAP -0.451620799574134 9.03523892284351e-05 NA NA NA hsa-miR-7-5p FGF1 3.59831747997243 0.000676336260217879 -0.904800782358151 0.37514033641596 miRNAWalker2_validate -0.227873135380002 0.000618398446708633 NA NA NA hsa-miR-10a-5p FGF11 -0.482300926520507 0.594608783320466 2.65301970671851 0.01261631469404 mirMAP -0.540123135463698 1.55078597656375e-17 NA NA NA hsa-miR-125a-5p FGF11 -1.32352790615388 0.00714301627309467 2.65301970671851 0.01261631469404 mirMAP -0.494060493961994 5.53596234226275e-05 NA NA NA hsa-miR-181c-5p FGF11 -0.302833440762172 0.537532549455539 2.65301970671851 0.01261631469404 mirMAP -0.333056312006498 0.00740153110235258 NA NA NA hsa-miR-199b-5p FGF11 -0.53728867775768 0.476885702455766 2.65301970671851 0.01261631469404 miRanda -0.226650311361356 0.00470364083999176 NA NA NA hsa-miR-28-5p FGF11 -0.815636722979196 0.0221199948901761 2.65301970671851 0.01261631469404 miRanda -0.597544575266832 0.000516029122759738 NA NA NA hsa-miR-335-5p FGF11 0.167216045757305 0.803897055331049 2.65301970671851 0.01261631469404 miRNAWalker2_validate;mirMAP -0.260708948424566 0.00379785190176695 NA NA NA hsa-miR-497-5p FGF11 -1.44150596209372 0.0225146607606395 2.65301970671851 0.01261631469404 mirMAP -0.379969738273999 6.46836099013065e-05 NA NA NA hsa-miR-532-3p FGF11 0.643755490841218 0.214842585969913 2.65301970671851 0.01261631469404 mirMAP -0.385940981743513 0.000977436732392584 NA NA NA hsa-miR-628-5p FGF11 1.04832355434705 0.0252368809675445 2.65301970671851 0.01261631469404 miRNATAP -0.392245033809592 0.00256535435087641 NA NA NA hsa-miR-142-5p FGF12 3.95552531913424 1.49536283724079e-08 -1.91394425895923 0.179665722286034 miRNATAP -0.299864470156096 0.00806374214219134 NA NA NA hsa-let-7b-3p FGF13 0.589364128513318 0.200507534602851 -4.85110267282668 1.82792041988563e-05 MirTarget;miRNATAP -0.380628231137145 0.00766409451664036 NA NA NA hsa-let-7f-1-3p FGF13 1.61507869803314 0.00069342464777815 -4.85110267282668 1.82792041988563e-05 MirTarget -0.586771661494691 1.64308196990907e-05 NA NA NA hsa-let-7f-2-3p FGF13 1.02768112108475 0.0787293499732611 -4.85110267282668 1.82792041988563e-05 MirTarget -0.357864947660702 0.00170173798430677 NA NA NA hsa-miR-141-3p FGF13 7.30474126597325 1.45115996357606e-24 -4.85110267282668 1.82792041988563e-05 TargetScan -0.376818681678676 5.94850485316558e-06 NA NA NA hsa-miR-142-5p FGF13 3.95552531913424 1.49536283724079e-08 -4.85110267282668 1.82792041988563e-05 PITA -0.371402228501292 3.90137579370002e-05 NA NA NA hsa-miR-200b-5p FGF13 6.81954246537908 6.31100593281326e-24 -4.85110267282668 1.82792041988563e-05 MirTarget -0.234643072355969 0.00846026232590831 NA NA NA hsa-miR-31-3p FGF13 5.7035081317825 2.15133648211091e-05 -4.85110267282668 1.82792041988563e-05 miRNATAP -0.423831416686979 5.37391529451371e-14 NA NA NA hsa-miR-362-3p FGF14 0.679952485897744 0.226148468488576 -3.2666985595731 0.00752892580587762 miRanda -0.453984416438245 0.000261413163907632 NA NA NA hsa-miR-421 FGF14 1.97624148591545 0.000915838012451138 -3.2666985595731 0.00752892580587762 miRanda -0.301541825920592 0.00981713310422506 NA NA NA hsa-miR-590-3p FGF14 2.35429565068338 2.79601879608564e-06 -3.2666985595731 0.00752892580587762 miRanda -0.538450638704515 7.86697187153333e-05 NA NA NA hsa-miR-15a-5p FGF18 2.0535411006904 1.91108976398046e-06 -3.01542595781322 0.0221151767151304 miRNATAP -0.460384004560966 0.00775915889139791 NA NA NA hsa-miR-16-5p FGF18 2.93575808220754 2.15436817162977e-10 -3.01542595781322 0.0221151767151304 miRNATAP -0.606136012766895 0.000120603503065243 NA NA NA hsa-miR-21-5p FGF18 2.65163477806992 6.72089787690756e-16 -3.01542595781322 0.0221151767151304 miRNATAP -0.796731311488867 0.000310248371727273 NA NA NA hsa-miR-330-5p FGF18 2.25110496739954 0.000275527655397415 -3.01542595781322 0.0221151767151304 PITA;miRanda;miRNATAP -0.705698029841673 1.94542850283262e-09 NA NA NA hsa-miR-15a-5p FGF2 2.0535411006904 1.91108976398046e-06 -4.7426237294682 2.88390048531716e-06 MirTarget;miRNATAP -0.544091858031343 4.73995293778273e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 2.83281226969693 7.54359864580834e-09 -4.7426237294682 2.88390048531716e-06 mirMAP -0.519661346969457 7.25223541348293e-06 NA NA NA hsa-miR-16-2-3p FGF2 3.79845098071094 1.49120139344659e-13 -4.7426237294682 2.88390048531716e-06 mirMAP -0.459075147077176 2.39530412317278e-05 NA NA NA hsa-miR-16-5p FGF2 2.93575808220754 2.15436817162977e-10 -4.7426237294682 2.88390048531716e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.382491794884229 0.00193553698923076 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-19b-1-5p FGF2 1.51335451095424 0.0014717605268143 -4.7426237294682 2.88390048531716e-06 mirMAP -0.48434219021616 7.33107402348553e-05 NA NA NA hsa-miR-200b-3p FGF2 5.56167217794639 6.43540045061709e-16 -4.7426237294682 2.88390048531716e-06 mirMAP -0.509650803431375 8.73024781893149e-11 NA NA NA hsa-miR-200c-3p FGF2 6.47012025883743 2.64500707716408e-26 -4.7426237294682 2.88390048531716e-06 mirMAP -0.509145367686688 3.3797939749436e-09 NA NA NA hsa-miR-21-5p FGF2 2.65163477806992 6.72089787690756e-16 -4.7426237294682 2.88390048531716e-06 mirMAP -0.567342076857507 0.00100450723749317 NA NA NA hsa-miR-429 FGF2 6.39965293994036 1.96920201593608e-18 -4.7426237294682 2.88390048531716e-06 mirMAP -0.436553293587648 3.16850635903379e-09 NA NA NA hsa-let-7a-5p FGF5 0.148081801547773 0.645305441523746 0.200823087926326 0.886420744796129 TargetScan -0.813305940889404 0.00135260763770948 NA NA NA hsa-miR-30d-5p FGF5 0.302504510257496 0.380193536606962 0.200823087926326 0.886420744796129 mirMAP -0.945453857735156 5.5835570510599e-05 NA NA NA hsa-miR-30e-5p FGF5 0.780047227271616 0.0346714425913016 0.200823087926326 0.886420744796129 mirMAP -1.10490128001329 3.05121006892414e-07 NA NA NA hsa-miR-9-5p FGF5 1.79620806707734 0.14526963042518 0.200823087926326 0.886420744796129 mirMAP;miRNATAP -0.175560006282005 0.00635183798944373 NA NA NA hsa-let-7f-1-3p FGF7 1.61507869803314 0.00069342464777815 -5.50929759175591 2.08834235862861e-09 MirTarget -0.504915790636748 6.53452218850079e-06 NA NA NA hsa-miR-107 FGF7 1.49443409571439 0.000130594521065411 -5.50929759175591 2.08834235862861e-09 PITA;miRanda;miRNATAP -0.548261828442942 6.19267572946103e-05 NA NA NA hsa-miR-15a-5p FGF7 2.0535411006904 1.91108976398046e-06 -5.50929759175591 2.08834235862861e-09 miRTarBase;miRNATAP -0.844172026292795 1.5837696168512e-12 NA NA NA hsa-miR-15b-5p FGF7 3.32329949959268 8.40210501034588e-13 -5.50929759175591 2.08834235862861e-09 miRNATAP -0.7640679607102 1.57490618059424e-12 NA NA NA hsa-miR-16-1-3p FGF7 2.83281226969693 7.54359864580834e-09 -5.50929759175591 2.08834235862861e-09 mirMAP -0.749629628439643 4.52180322532678e-13 NA NA NA hsa-miR-16-2-3p FGF7 3.79845098071094 1.49120139344659e-13 -5.50929759175591 2.08834235862861e-09 mirMAP -0.847381900594552 4.32516753936814e-19 NA NA NA hsa-miR-16-5p FGF7 2.93575808220754 2.15436817162977e-10 -5.50929759175591 2.08834235862861e-09 miRNATAP -0.832832684493506 1.97867385329742e-14 NA NA NA hsa-miR-18a-3p FGF7 3.64944956993027 7.20156641833731e-07 -5.50929759175591 2.08834235862861e-09 MirTarget -0.441945882479192 2.84966542079581e-10 NA NA NA hsa-miR-20a-5p FGF7 2.13553469875764 0.000181201072324354 -5.50929759175591 2.08834235862861e-09 miRNAWalker2_validate -0.65813811876502 2.66086843741942e-13 NA NA NA hsa-miR-27a-3p FGF7 1.76094007417453 0.000216137556256765 -5.50929759175591 2.08834235862861e-09 MirTarget -0.395277535599951 0.000415972824808002 NA NA NA hsa-miR-30d-3p FGF7 -0.0740421896025512 0.857423650167556 -5.50929759175591 2.08834235862861e-09 miRNATAP -0.423853277659603 0.00128430415264874 NA NA NA hsa-miR-31-5p FGF7 7.15600983164746 6.64190917357724e-10 -5.50929759175591 2.08834235862861e-09 MirTarget -0.231105084817746 1.55520868035105e-07 NA NA NA hsa-miR-33a-3p FGF7 2.06269680799532 0.00156436055383943 -5.50929759175591 2.08834235862861e-09 mirMAP -0.324782867305881 6.90222589126918e-05 NA NA NA hsa-miR-429 FGF7 6.39965293994036 1.96920201593608e-18 -5.50929759175591 2.08834235862861e-09 miRNATAP -0.390059511354549 8.41914783540908e-09 NA NA NA hsa-miR-452-5p FGF7 2.45466810475361 0.00114794259949532 -5.50929759175591 2.08834235862861e-09 mirMAP -0.203492053036003 0.00386119935433002 NA NA NA hsa-miR-484 FGF7 1.79050445056016 0.000217287101253701 -5.50929759175591 2.08834235862861e-09 PITA -0.554919826238732 3.43164388632413e-07 NA NA NA hsa-miR-486-5p FGF7 1.10898145177457 0.309287974401609 -5.50929759175591 2.08834235862861e-09 MirTarget;miRanda -0.199101289167256 4.2632039983384e-05 NA NA NA hsa-miR-501-5p FGF7 1.0411896821345 0.0777206709183552 -5.50929759175591 2.08834235862861e-09 PITA;mirMAP -0.278893841915656 0.00214739894695432 NA NA NA hsa-miR-590-3p FGF7 2.35429565068338 2.79601879608564e-06 -5.50929759175591 2.08834235862861e-09 PITA;miRanda;mirMAP;miRNATAP -0.423372011062578 5.43468998349422e-05 NA NA NA hsa-miR-590-5p FGF7 1.51400888103768 0.0023888567923017 -5.50929759175591 2.08834235862861e-09 PITA;miRanda -0.510281508234044 1.57446299231047e-06 NA NA NA hsa-miR-616-5p FGF7 2.48416313933027 0.00318247475868827 -5.50929759175591 2.08834235862861e-09 mirMAP -0.370056256625251 2.39061229012998e-06 NA NA NA hsa-miR-7-1-3p FGF7 1.43074343339835 0.00471215970502094 -5.50929759175591 2.08834235862861e-09 mirMAP -0.274609644788141 0.00965187913472911 NA NA NA hsa-miR-142-3p FGF9 4.35304505457969 3.10014573651358e-10 -4.08682393789453 0.0107258337159531 miRanda -0.401753640799601 0.00167098844620533 NA NA NA hsa-miR-142-5p FGF9 3.95552531913424 1.49536283724079e-08 -4.08682393789453 0.0107258337159531 mirMAP -0.595282456453426 2.31469482732197e-06 NA NA NA hsa-miR-155-5p FGF9 2.81443182173772 7.42530504828797e-05 -4.08682393789453 0.0107258337159531 miRNATAP -0.519448274223347 3.79320362704427e-05 NA NA NA hsa-miR-15b-5p FGF9 3.32329949959268 8.40210501034588e-13 -4.08682393789453 0.0107258337159531 miRNATAP -0.57369666067076 0.00255066397006186 NA NA NA hsa-miR-16-2-3p FGF9 3.79845098071094 1.49120139344659e-13 -4.08682393789453 0.0107258337159531 mirMAP -0.737702008973209 1.35213419742742e-05 NA NA NA hsa-miR-16-5p FGF9 2.93575808220754 2.15436817162977e-10 -4.08682393789453 0.0107258337159531 miRNATAP -0.626240493508557 0.00114127711677494 NA NA NA hsa-miR-205-5p FGF9 8.08298115900323 3.83045179398654e-07 -4.08682393789453 0.0107258337159531 miRNATAP -0.407807926248114 3.31451700237078e-14 NA NA NA hsa-miR-221-5p FGF9 2.07459535854377 0.0757339015356929 -4.08682393789453 0.0107258337159531 miRNATAP -0.265306408034282 0.000712187163376646 NA NA NA hsa-miR-330-5p FGF9 2.25110496739954 0.000275527655397415 -4.08682393789453 0.0107258337159531 miRanda;miRNATAP -0.87177733723282 1.06930871304638e-09 NA NA NA hsa-miR-582-5p FGF9 0.685177900016753 0.447761540297692 -4.08682393789453 0.0107258337159531 miRNATAP -0.314179765499692 0.00182764604876116 NA NA NA hsa-miR-590-3p FGF9 2.35429565068338 2.79601879608564e-06 -4.08682393789453 0.0107258337159531 miRanda;mirMAP -0.664491628866496 0.000203762257139799 NA NA NA hsa-miR-944 FGF9 7.20925181386398 0.000823207457340648 -4.08682393789453 0.0107258337159531 mirMAP -0.416792870999897 4.0818129784972e-17 NA NA NA hsa-miR-106b-5p FGFR1 2.80565545918114 1.14547999022566e-09 -3.68099244503292 0.000117634214619712 mirMAP -0.32757862591401 0.00493739743042474 NA NA NA hsa-miR-15a-5p FGFR1 2.0535411006904 1.91108976398046e-06 -3.68099244503292 0.000117634214619712 miRNATAP -0.446444424510866 0.000387045493423854 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 2.93575808220754 2.15436817162977e-10 -3.68099244503292 0.000117634214619712 miRTarBase;miRNATAP -0.563686110844188 8.1915486423705e-07 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-200b-5p FGFR1 6.81954246537908 6.31100593281326e-24 -3.68099244503292 0.000117634214619712 mirMAP -0.204584689815958 0.00635940451614134 NA NA NA hsa-miR-330-3p FGFR1 2.49094236945806 0.000129367003214715 -3.68099244503292 0.000117634214619712 PITA;miRNATAP -0.379471838740622 4.59253778797009e-06 NA NA NA hsa-miR-330-5p FGFR1 2.25110496739954 0.000275527655397415 -3.68099244503292 0.000117634214619712 miRanda;miRNATAP -0.441444867608315 3.45510180905413e-07 NA NA NA hsa-miR-590-3p FGFR1 2.35429565068338 2.79601879608564e-06 -3.68099244503292 0.000117634214619712 miRanda;mirMAP -0.348430851362078 0.00121803566976507 NA NA NA hsa-miR-146b-5p FGFR2 1.87569569182453 0.000737241069698886 -1.54795077473676 0.070591459239545 miRanda -0.298378342872546 0.000592636062336762 NA NA NA hsa-miR-330-5p FGFR2 2.25110496739954 0.000275527655397415 -1.54795077473676 0.070591459239545 miRanda -0.389349119984991 4.06955034955631e-07 NA NA NA hsa-miR-338-3p FGFR2 0.447551118940466 0.558485097370031 -1.54795077473676 0.070591459239545 miRanda;miRNATAP -0.19939075618371 0.00167905513044275 NA NA NA hsa-miR-194-5p FGFR3 0.691219038144468 0.523143086635506 3.48521641699525 0.00307155788964699 miRNATAP -0.211217272614244 0.000618688146002221 NA NA NA hsa-miR-99b-5p FGFR3 -0.796155507439137 0.153001114953768 3.48521641699525 0.00307155788964699 MirTarget;miRNATAP -0.821514573127916 2.25366377381863e-12 22969861 miR-99b was downregulated and FGFR3 was upregulated in lung cancer patients; We demonstrated that the overexpression of miR-99b induced a reduction in FGFR3 expression and confirmed the target specificity between miR-99b and the FGFR3 3'-untranslated region by luciferase reporter assay; Taken together these results suggest that miR-99b may be a tumor suppressor through the downregulation of FGFR3 miR-99b may be a potent tumor suppressor and may be a potential therapeutic tool for patients with lung cancer lung squamous cell cancer hsa-miR-200c-3p FLNA 6.47012025883743 2.64500707716408e-26 -2.74909594751263 1.93215705156445e-05 miRNAWalker2_validate -0.288078196729452 1.44623491387617e-07 NA NA NA hsa-miR-502-5p FLNB -0.614788359240004 0.318237800399635 0.341251492592823 0.506875611060452 mirMAP -0.141368652431669 0.00363238827698295 NA NA NA hsa-miR-532-5p FLNB -0.297424983759107 0.503934707453099 0.341251492592823 0.506875611060452 mirMAP -0.288022849635952 1.07861403263854e-05 NA NA NA hsa-miR-454-3p FLNC 1.40269869979902 0.00366085847011367 -5.77375333036027 4.40397602831494e-06 miRNAWalker2_validate -0.437633832694302 0.00360756101016861 NA NA NA hsa-miR-592 FLNC 2.80403350008555 0.0293520213681333 -5.77375333036027 4.40397602831494e-06 mirMAP -0.21728547814005 0.00158186852156426 NA NA NA hsa-miR-335-3p FOS 1.19503568251824 0.0938852560631551 -2.5588867561531 0.00999589770980676 MirTarget -0.208661063677506 0.00849999917850608 NA NA NA hsa-miR-362-3p FOS 0.679952485897744 0.226148468488576 -2.5588867561531 0.00999589770980676 miRanda -0.265126811775231 0.00901774543104591 NA NA NA hsa-miR-129-5p GADD45A -2.66843722411409 0.00695783358331245 -0.566112082294352 0.356860494529648 miRanda -0.100844116127556 0.00449173907374446 NA NA NA hsa-miR-130b-3p GADD45A 3.9204771543282 1.2714917955808e-11 -0.566112082294352 0.356860494529648 MirTarget;miRNATAP -0.171179592036229 0.0032386084520536 NA NA NA hsa-miR-146b-5p GADD45A 1.87569569182453 0.000737241069698886 -0.566112082294352 0.356860494529648 miRanda -0.18967214107464 0.00232775278051048 NA NA NA hsa-miR-148b-3p GADD45A 1.75622244535669 8.84414356040579e-08 -0.566112082294352 0.356860494529648 MirTarget -0.525743475009119 5.01282872316168e-07 NA NA NA hsa-miR-301a-3p GADD45A 1.99338115332667 0.000813358604963724 -0.566112082294352 0.356860494529648 MirTarget;miRNATAP -0.190939096191683 0.000994881284680524 NA NA NA hsa-miR-362-5p GADD45A -1.22309034685697 0.0452665543907975 -0.566112082294352 0.356860494529648 MirTarget;PITA;miRNATAP -0.174083394504546 0.00221778809043954 NA NA NA hsa-miR-375 GADD45A 3.3784490463318 0.0449946294355695 -0.566112082294352 0.356860494529648 miRanda -0.102232241980599 4.20822114251968e-07 NA NA NA hsa-miR-454-3p GADD45A 1.40269869979902 0.00366085847011367 -0.566112082294352 0.356860494529648 MirTarget;miRNATAP -0.309147097462117 1.56973939454024e-05 NA NA NA hsa-miR-500a-5p GADD45A 0.0170829425378565 0.973960207660626 -0.566112082294352 0.356860494529648 MirTarget;miRNATAP -0.191557624174549 0.00426069074325481 NA NA NA hsa-miR-500b-5p GADD45A 0.0167434146432646 0.974498641907253 -0.566112082294352 0.356860494529648 MirTarget -0.191191795665263 0.0043023159901196 NA NA NA hsa-miR-324-3p GADD45B 1.51345381556672 0.0038447546677657 -1.882739402569 0.00168698437811886 MirTarget;miRNATAP -0.17112830558095 0.00882982096915685 NA NA NA hsa-miR-1976 GADD45G 3.27217274919653 3.16337235854532e-12 -3.78199148373951 7.47113859248823e-06 MirTarget -0.339364756241224 0.000704281453896161 NA NA NA hsa-miR-141-3p GNA12 7.30474126597325 1.45115996357606e-24 -1.25516702951645 0.000587921757078316 mirMAP -0.103552002208584 0.000104959357211015 NA NA NA hsa-miR-200a-3p GNA12 6.336081120041 4.024313571871e-16 -1.25516702951645 0.000587921757078316 mirMAP -0.178663238231361 2.63383634041315e-13 NA NA NA hsa-miR-30e-3p GNA12 -0.0362193022195196 0.932577027239525 -1.25516702951645 0.000587921757078316 MirTarget -0.162039432879845 0.000958077454413367 NA NA NA hsa-miR-497-5p GNA12 -1.44150596209372 0.0225146607606395 -1.25516702951645 0.000587921757078316 MirTarget -0.117247045850121 0.000341985988137782 NA NA NA hsa-miR-107 GNG12 1.49443409571439 0.000130594521065411 -0.886730549936608 0.0548755138724675 miRanda -0.375379591214763 1.2611761046531e-08 NA NA NA hsa-miR-186-5p GNG12 0.445443449112564 0.185447310527704 -0.886730549936608 0.0548755138724675 miRNAWalker2_validate -0.367159470028634 3.06448364501308e-06 NA NA NA hsa-miR-28-5p GNG12 -0.815636722979196 0.0221199948901761 -0.886730549936608 0.0548755138724675 PITA;miRanda -0.21959951908093 0.00323834417968406 NA NA NA hsa-miR-30d-3p GNG12 -0.0740421896025512 0.857423650167556 -0.886730549936608 0.0548755138724675 mirMAP -0.294933914805506 3.66263698042787e-06 NA NA NA hsa-miR-423-5p GNG12 0.227366878624794 0.5653498335202 -0.886730549936608 0.0548755138724675 miRNAWalker2_validate -0.257155822338734 0.000119401413269023 NA NA NA hsa-miR-429 GNG12 6.39965293994036 1.96920201593608e-18 -0.886730549936608 0.0548755138724675 miRanda -0.174749824561321 1.42475980670021e-07 NA NA NA hsa-miR-590-3p GNG12 2.35429565068338 2.79601879608564e-06 -0.886730549936608 0.0548755138724675 miRanda;mirMAP -0.195519764941412 0.000137706236894006 NA NA NA hsa-miR-590-5p GNG12 1.51400888103768 0.0023888567923017 -0.886730549936608 0.0548755138724675 PITA -0.204130947938636 9.24784233305571e-05 NA NA NA hsa-miR-96-5p GNG12 5.62521466029286 1.54938806718028e-10 -0.886730549936608 0.0548755138724675 TargetScan -0.227994483286262 3.07845742736986e-11 NA NA NA hsa-miR-125a-5p HSPA1A -1.32352790615388 0.00714301627309467 0.359425658071565 0.490065666501168 miRanda -0.190220424395359 0.0014961137101872 NA NA NA hsa-miR-125b-5p HSPA1B -2.01187572101832 0.00516480893645494 0.478430328427693 0.351373623003061 miRNAWalker2_validate -0.128025344581324 0.00140678197118189 NA NA NA hsa-miR-192-5p HSPA2 1.77716187978541 0.113485496183047 -0.060615621181209 0.954264711469165 miRNAWalker2_validate -0.253602324930188 1.31499053633745e-06 NA NA NA hsa-miR-215-5p HSPA2 3.66990923176752 0.00294614570694381 -0.060615621181209 0.954264711469165 miRNAWalker2_validate -0.175532712879965 0.000246983574738192 NA NA NA hsa-let-7b-5p HSPA8 -0.189422992330471 0.651878220048983 0.351214124255476 0.449193523188164 miRNAWalker2_validate -0.168291493693624 0.00790239926644958 NA NA NA hsa-miR-199a-5p HSPA8 -1.24888110793613 0.0747755616523728 0.351214124255476 0.449193523188164 miRanda -0.12271363438377 0.00100345392160928 NA NA NA hsa-miR-199b-5p HSPA8 -0.53728867775768 0.476885702455766 0.351214124255476 0.449193523188164 miRanda -0.100795167512747 0.00370105487366971 NA NA NA hsa-miR-151a-3p IKBKB 0.373902859770645 0.376924505912903 0.104177496834708 0.718852918781577 miRNAWalker2_validate -0.121270812981731 0.00180898875297091 NA NA NA hsa-miR-339-5p IKBKB 1.23326828594484 0.0307501214818698 0.104177496834708 0.718852918781577 miRanda -0.112704791185609 7.01383121429463e-05 NA NA NA hsa-miR-542-3p IKBKB -0.376147863244659 0.438002751207043 0.104177496834708 0.718852918781577 miRanda -0.1114840138672 0.000952486304701064 NA NA NA hsa-miR-125a-5p IKBKG -1.32352790615388 0.00714301627309467 0.217673245627403 0.541287587904691 miRanda -0.110235437146931 0.00712043030373108 NA NA NA hsa-miR-338-5p IKBKG -0.108304629897487 0.894675560494607 0.217673245627403 0.541287587904691 mirMAP -0.107990652303128 1.00066234929907e-05 NA NA NA hsa-miR-181c-5p IL1A -0.302833440762172 0.537532549455539 4.31599389135009 0.0104359859237567 MirTarget -0.750864040262053 0.000127388155916292 NA NA NA hsa-miR-191-5p IL1A 1.58824208483839 0.000738859004053681 4.31599389135009 0.0104359859237567 miRNAWalker2_validate -0.920302645458858 5.18012425368392e-06 NA NA NA hsa-miR-200a-3p IL1A 6.336081120041 4.024313571871e-16 4.31599389135009 0.0104359859237567 MirTarget -0.461162168953321 7.32399186286365e-05 NA NA NA hsa-miR-30a-5p IL1A -0.768430903969183 0.320487552854215 4.31599389135009 0.0104359859237567 MirTarget -0.52318793715064 2.12283658834032e-05 NA NA NA hsa-miR-532-5p IL1A -0.297424983759107 0.503934707453099 4.31599389135009 0.0104359859237567 MirTarget -1.49939259880363 1.12516024441561e-12 NA NA NA hsa-miR-17-3p IL1R1 1.2477858204856 0.00186593270231258 -2.02737457884455 0.00137078637258843 mirMAP -0.478550922210701 8.17349650316603e-08 NA NA NA hsa-miR-335-3p IL1R1 1.19503568251824 0.0938852560631551 -2.02737457884455 0.00137078637258843 mirMAP -0.223081090533626 8.58843025959345e-06 NA NA NA hsa-miR-141-3p JUN 7.30474126597325 1.45115996357606e-24 -1.39678224976456 0.0210065056705043 miRNATAP -0.140631808287642 0.00151406596577943 NA NA NA hsa-miR-30a-5p JUN -0.768430903969183 0.320487552854215 -1.39678224976456 0.0210065056705043 miRNAWalker2_validate -0.152843415788565 0.000559974108995951 NA NA NA hsa-miR-590-3p KRAS 2.35429565068338 2.79601879608564e-06 0.397475629872277 0.267914845700271 PITA;miRanda;mirMAP -0.104783145997534 0.00867065435764531 NA NA NA hsa-miR-101-3p MAP2K1 -1.12421603598195 0.0200907284788457 0.519316108483181 0.113764633840027 miRNAWalker2_validate -0.210296378296097 2.59354101164885e-08 NA NA NA hsa-miR-140-3p MAP2K1 -1.9828800596692 8.92876132959514e-08 0.519316108483181 0.113764633840027 PITA -0.134317183064192 0.00692981390628658 NA NA NA hsa-miR-497-5p MAP2K1 -1.44150596209372 0.0225146607606395 0.519316108483181 0.113764633840027 miRNAWalker2_validate -0.157096186222573 4.82243556573134e-08 NA NA NA hsa-miR-193a-3p MAP2K6 0.646392169474854 0.207134343676122 0.366987244970754 0.658729915051349 miRanda -0.369493220252656 5.66658196338422e-05 NA NA NA hsa-miR-125a-5p MAP2K7 -1.32352790615388 0.00714301627309467 -0.549908562204148 0.0367965515297203 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.104592296002655 0.000515096009136123 NA NA NA hsa-let-7d-5p MAP3K1 0.831142050231414 0.0126955498524287 0.634215972142603 0.181579485320679 miRNATAP -0.364788580150107 7.23852116983813e-06 NA NA NA hsa-let-7e-5p MAP3K1 -0.111012524740586 0.814744515884005 0.634215972142603 0.181579485320679 miRNATAP -0.183207364946524 0.00134140785238357 NA NA NA hsa-miR-130a-5p MAP3K1 1.58028512890005 0.024346333013728 0.634215972142603 0.181579485320679 miRNATAP -0.105205478709336 0.00684300560606387 NA NA NA hsa-miR-18a-5p MAP3K1 3.90770175770219 9.15298615034137e-10 0.634215972142603 0.181579485320679 miRNATAP -0.149557497728599 0.000245461093602782 NA NA NA hsa-miR-32-3p MAP3K1 2.20477794939766 0.0392771274032852 0.634215972142603 0.181579485320679 mirMAP -0.14712221793757 0.000853101077522533 NA NA NA hsa-miR-339-5p MAP3K1 1.23326828594484 0.0307501214818698 0.634215972142603 0.181579485320679 miRanda -0.266410565820316 7.8397838800987e-09 NA NA NA hsa-miR-421 MAP3K1 1.97624148591545 0.000915838012451138 0.634215972142603 0.181579485320679 miRanda -0.154707471093947 0.000561862724781499 NA NA NA hsa-miR-423-3p MAP3K1 1.7128674316395 1.7145324528301e-05 0.634215972142603 0.181579485320679 miRNAWalker2_validate -0.234323454643542 0.000489312696015976 NA NA NA hsa-miR-582-5p MAP3K1 0.685177900016753 0.447761540297692 0.634215972142603 0.181579485320679 PITA;miRNATAP -0.127070074656348 1.61541693874447e-05 NA NA NA hsa-miR-590-3p MAP3K1 2.35429565068338 2.79601879608564e-06 0.634215972142603 0.181579485320679 PITA;miRanda;mirMAP -0.158413642119026 0.00273901785121005 NA NA NA hsa-miR-590-5p MAP3K1 1.51400888103768 0.0023888567923017 0.634215972142603 0.181579485320679 PITA;miRanda;miRNATAP -0.197887172564104 0.000226732111292916 NA NA NA hsa-miR-106b-5p MAP3K12 2.80565545918114 1.14547999022566e-09 -2.51383227649074 1.30414732983547e-05 MirTarget -0.198173484574605 0.00490609967217734 NA NA NA hsa-miR-17-5p MAP3K12 2.3269271449522 2.13987445663942e-05 -2.51383227649074 1.30414732983547e-05 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.155393383815928 0.00961943344255689 NA NA NA hsa-miR-27a-3p MAP3K12 1.76094007417453 0.000216137556256765 -2.51383227649074 1.30414732983547e-05 miRNATAP -0.38775527516291 1.23432526338764e-08 NA NA NA hsa-miR-27b-3p MAP3K12 -0.0929089601968123 0.85847352206581 -2.51383227649074 1.30414732983547e-05 miRNATAP -0.220546772018071 0.00054664564904905 NA NA NA hsa-miR-429 MAP3K12 6.39965293994036 1.96920201593608e-18 -2.51383227649074 1.30414732983547e-05 miRNATAP -0.132506838822115 0.00188819240605689 NA NA NA hsa-miR-590-3p MAP3K12 2.35429565068338 2.79601879608564e-06 -2.51383227649074 1.30414732983547e-05 miRanda -0.225346667182433 0.000530547487776947 NA NA NA hsa-miR-93-5p MAP3K12 2.65964181833033 2.58315947526774e-08 -2.51383227649074 1.30414732983547e-05 MirTarget -0.181903027174191 0.00771490928743872 NA NA NA hsa-miR-1271-5p MAP3K13 0.212382644103427 0.742544160267329 1.55364646091131 0.0545903946362617 mirMAP -0.303921736384105 1.71587833386431e-05 NA NA NA hsa-miR-17-5p MAP3K13 2.3269271449522 2.13987445663942e-05 1.55364646091131 0.0545903946362617 miRNATAP -0.277771577638803 0.000802513099360054 NA NA NA hsa-miR-186-5p MAP3K13 0.445443449112564 0.185447310527704 1.55364646091131 0.0545903946362617 mirMAP -0.485681913727282 0.000478694862174128 NA NA NA hsa-miR-20a-3p MAP3K13 1.9920766549842 0.000624458530894697 1.55364646091131 0.0545903946362617 mirMAP -0.313411364770649 5.75276870987336e-05 NA NA NA hsa-miR-23a-3p MAP3K13 0.925125296618358 0.0127293543936914 1.55364646091131 0.0545903946362617 mirMAP -0.438520961527972 0.000443386198167815 NA NA NA hsa-miR-24-3p MAP3K13 1.55853749533999 0.000524726461381821 1.55364646091131 0.0545903946362617 MirTarget -0.292660887179648 0.00419978353218452 NA NA NA hsa-miR-320a MAP3K13 -0.912036444869976 0.0565555443926988 1.55364646091131 0.0545903946362617 mirMAP -0.284306685785252 0.00321736631906073 NA NA NA hsa-miR-320b MAP3K13 0.20205459771295 0.727216419960509 1.55364646091131 0.0545903946362617 mirMAP -0.262909627503661 0.000930774361107922 NA NA NA hsa-miR-320c MAP3K13 -0.10618808730545 0.854002814666472 1.55364646091131 0.0545903946362617 mirMAP -0.282511431129725 0.000497417049116625 NA NA NA hsa-miR-339-5p MAP3K13 1.23326828594484 0.0307501214818698 1.55364646091131 0.0545903946362617 miRanda -0.216950221384558 0.00706777539682251 NA NA NA hsa-miR-3607-3p MAP3K13 1.38015131722213 0.0240067155694847 1.55364646091131 0.0545903946362617 mirMAP -0.195984089040435 0.00906285318083474 NA NA NA hsa-miR-502-5p MAP3K13 -0.614788359240004 0.318237800399635 1.55364646091131 0.0545903946362617 miRNATAP -0.270631966086138 0.000402417143313616 NA NA NA hsa-miR-505-3p MAP3K13 0.58881333170866 0.226937454637888 1.55364646091131 0.0545903946362617 mirMAP -0.281730228432896 0.00296919610050046 NA NA NA hsa-miR-508-3p MAP3K13 0.975099105064348 0.439528954969797 1.55364646091131 0.0545903946362617 miRNATAP -0.101621906221687 0.00561340321992719 NA NA NA hsa-miR-877-5p MAP3K13 3.67317721493893 4.85916829184578e-06 1.55364646091131 0.0545903946362617 miRNATAP -0.154750578507811 0.00646484547548014 NA NA NA hsa-miR-940 MAP3K13 3.78496690968119 4.75227557809023e-05 1.55364646091131 0.0545903946362617 MirTarget;miRNATAP -0.195915509704997 0.000994136009677296 NA NA NA hsa-miR-17-5p MAP3K14 2.3269271449522 2.13987445663942e-05 -0.572095255643433 0.232052277296526 MirTarget -0.154710364889365 0.00157167780275142 NA NA NA hsa-miR-345-5p MAP3K14 2.77314563304336 4.34343702412489e-05 -0.572095255643433 0.232052277296526 MirTarget -0.103524963377024 0.00878161781449097 NA NA NA hsa-miR-429 MAP3K14 6.39965293994036 1.96920201593608e-18 -0.572095255643433 0.232052277296526 miRNATAP -0.116936681153463 0.000784919148104685 NA NA NA hsa-miR-93-5p MAP3K14 2.65964181833033 2.58315947526774e-08 -0.572095255643433 0.232052277296526 MirTarget -0.2276783161594 3.94079758590909e-05 NA NA NA hsa-let-7d-5p MAP3K2 0.831142050231414 0.0126955498524287 0.805069170331161 0.0705017934974758 miRNATAP -0.21076575260105 0.00624878542416936 NA NA NA hsa-let-7g-3p MAP3K2 2.09736290930341 5.30067796437833e-05 0.805069170331161 0.0705017934974758 miRNATAP -0.128730425398934 0.00770252845966233 NA NA NA hsa-miR-148b-5p MAP3K2 2.80812018666078 3.97536665756679e-08 0.805069170331161 0.0705017934974758 mirMAP -0.128374990377751 0.0082233295013966 NA NA NA hsa-miR-30b-5p MAP3K2 0.0238659735605804 0.953223658270319 0.805069170331161 0.0705017934974758 mirMAP;miRNATAP -0.174430247742025 0.00553860233700377 NA NA NA hsa-miR-30e-5p MAP3K2 0.780047227271616 0.0346714425913016 0.805069170331161 0.0705017934974758 mirMAP -0.209598443380224 0.00246526197121921 NA NA NA hsa-miR-335-3p MAP3K2 1.19503568251824 0.0938852560631551 0.805069170331161 0.0705017934974758 MirTarget;mirMAP -0.112024601016203 0.00148014350116477 NA NA NA hsa-miR-335-5p MAP3K2 0.167216045757305 0.803897055331049 0.805069170331161 0.0705017934974758 mirMAP;miRNATAP -0.104948312443026 0.0051493257636881 NA NA NA hsa-miR-3607-3p MAP3K2 1.38015131722213 0.0240067155694847 0.805069170331161 0.0705017934974758 MirTarget;miRNATAP -0.124799203715349 0.00243003873856354 NA NA NA hsa-miR-590-3p MAP3K2 2.35429565068338 2.79601879608564e-06 0.805069170331161 0.0705017934974758 miRanda;miRNATAP -0.135619002628628 0.00633851821870267 NA NA NA hsa-miR-106b-5p MAP3K3 2.80565545918114 1.14547999022566e-09 -1.60402819876079 1.58145535314045e-06 MirTarget;miRNATAP -0.164478465228658 4.89480997327766e-05 NA NA NA hsa-miR-107 MAP3K3 1.49443409571439 0.000130594521065411 -1.60402819876079 1.58145535314045e-06 PITA;miRanda;miRNATAP -0.131917559525224 0.0074843492124784 NA NA NA hsa-miR-141-3p MAP3K3 7.30474126597325 1.45115996357606e-24 -1.60402819876079 1.58145535314045e-06 miRNATAP -0.138677777288729 1.11882556474274e-08 NA NA NA hsa-miR-15b-5p MAP3K3 3.32329949959268 8.40210501034588e-13 -1.60402819876079 1.58145535314045e-06 MirTarget;miRNATAP -0.129645780076453 0.00116299034930129 NA NA NA hsa-miR-16-5p MAP3K3 2.93575808220754 2.15436817162977e-10 -1.60402819876079 1.58145535314045e-06 MirTarget;miRNATAP -0.122053907862992 0.00258809473242049 NA NA NA hsa-miR-182-5p MAP3K3 5.86988712704738 1.22411588571584e-15 -1.60402819876079 1.58145535314045e-06 miRNATAP -0.154334398006422 1.88096423444319e-10 NA NA NA hsa-miR-200a-3p MAP3K3 6.336081120041 4.024313571871e-16 -1.60402819876079 1.58145535314045e-06 miRNATAP -0.119793449484591 1.94872927416047e-07 NA NA NA hsa-miR-331-3p MAP3K3 2.60769294751513 3.84318952029483e-07 -1.60402819876079 1.58145535314045e-06 mirMAP -0.141816846264073 0.000107437946809823 NA NA NA hsa-miR-33b-5p MAP3K3 4.77891217497671 1.33695107675057e-08 -1.60402819876079 1.58145535314045e-06 miRNATAP -0.102710998957921 3.24395910688525e-06 NA NA NA hsa-miR-423-5p MAP3K3 0.227366878624794 0.5653498335202 -1.60402819876079 1.58145535314045e-06 PITA -0.140382767293218 0.00436004005807662 NA NA NA hsa-miR-429 MAP3K3 6.39965293994036 1.96920201593608e-18 -1.60402819876079 1.58145535314045e-06 miRNATAP -0.14719722397151 1.09409212541188e-09 NA NA NA hsa-miR-484 MAP3K3 1.79050445056016 0.000217287101253701 -1.60402819876079 1.58145535314045e-06 miRNATAP -0.143551921600818 0.000263419276505133 NA NA NA hsa-miR-505-3p MAP3K3 0.58881333170866 0.226937454637888 -1.60402819876079 1.58145535314045e-06 miRNATAP -0.114299733135479 0.00392903907781257 NA NA NA hsa-miR-7-1-3p MAP3K3 1.43074343339835 0.00471215970502094 -1.60402819876079 1.58145535314045e-06 mirMAP -0.128661123058464 0.000666872570146765 NA NA NA hsa-miR-93-5p MAP3K3 2.65964181833033 2.58315947526774e-08 -1.60402819876079 1.58145535314045e-06 MirTarget;miRNATAP -0.12672284558889 0.00130869469005309 NA NA NA hsa-miR-96-5p MAP3K3 5.62521466029286 1.54938806718028e-10 -1.60402819876079 1.58145535314045e-06 MirTarget;TargetScan;miRNATAP -0.12602583677277 8.12772948711807e-07 NA NA NA hsa-miR-142-3p MAP3K4 4.35304505457969 3.10014573651358e-10 -0.122859531975687 0.731285462015537 miRanda -0.109437899201451 0.000100372833967066 NA NA NA hsa-miR-148a-3p MAP3K4 1.1031350648218 0.052038169812979 -0.122859531975687 0.731285462015537 miRNAWalker2_validate -0.150434992822368 2.02796054035136e-05 NA NA NA hsa-miR-590-3p MAP3K4 2.35429565068338 2.79601879608564e-06 -0.122859531975687 0.731285462015537 miRanda -0.153892796320856 9.79508130349398e-05 NA NA NA hsa-miR-17-5p MAP3K5 2.3269271449522 2.13987445663942e-05 0.451793768919489 0.393484533177232 TargetScan;miRNATAP -0.178294014467127 0.000980117504572778 NA NA NA hsa-miR-30a-5p MAP3K5 -0.768430903969183 0.320487552854215 0.451793768919489 0.393484533177232 miRNATAP -0.164745307798725 1.76963779122944e-05 NA NA NA hsa-miR-30c-5p MAP3K5 0.38723991118075 0.348605235643473 0.451793768919489 0.393484533177232 miRNATAP -0.218567170842163 0.00290942159170444 NA NA NA hsa-miR-769-3p MAP3K5 1.74947739956763 0.0310790621215023 0.451793768919489 0.393484533177232 miRNAWalker2_validate -0.162994181583283 0.000288258268337876 NA NA NA hsa-miR-93-5p MAP3K5 2.65964181833033 2.58315947526774e-08 0.451793768919489 0.393484533177232 miRNATAP -0.164609782846102 0.00767432356757556 NA NA NA hsa-miR-592 MAP3K6 2.80403350008555 0.0293520213681333 0.508710643535312 0.358006971408253 miRNATAP -0.111866121908603 0.000159136337401046 NA NA NA hsa-miR-29a-5p MAP3K7 0.0748295222568571 0.884125894063293 0.316391433469006 0.292968544589595 mirMAP -0.123297042652905 0.000192527325272211 NA NA NA hsa-miR-34a-5p MAP3K7 0.830377770217786 0.0477544831885907 0.316391433469006 0.292968544589595 miRNAWalker2_validate -0.115410514352201 0.00466228094371235 NA NA NA hsa-miR-664a-3p MAP3K7 0.249882351950296 0.56171157318348 0.316391433469006 0.292968544589595 MirTarget;mirMAP -0.129722952536066 0.00109384610601403 NA NA NA hsa-miR-106a-5p MAP3K8 3.98693608217557 9.37722470816656e-07 -0.46490218064813 0.400496447648945 MirTarget;miRNATAP -0.158462320145219 2.31885012156731e-05 NA NA NA hsa-miR-128-3p MAP3K8 1.36248409467631 0.00408435995818078 -0.46490218064813 0.400496447648945 MirTarget -0.214817278106776 0.0011296906390809 NA NA NA hsa-miR-181b-5p MAP3K8 1.11397227523501 0.0273417050354018 -0.46490218064813 0.400496447648945 MirTarget -0.21123142060931 0.000660180463312735 NA NA NA hsa-miR-20b-5p MAP3K8 4.5662923200279 4.75238200639144e-05 -0.46490218064813 0.400496447648945 MirTarget;miRNATAP -0.10603133017929 0.000101608143873447 NA NA NA hsa-miR-335-5p MAP3K8 0.167216045757305 0.803897055331049 -0.46490218064813 0.400496447648945 miRNAWalker2_validate -0.141061075149295 0.00242343468257494 NA NA NA hsa-miR-30c-2-3p MAP4K1 -0.916427677918778 0.300195789569016 1.20358484448824 0.144713122790647 MirTarget -0.161048977611757 0.0022727247535657 NA NA NA hsa-miR-142-3p MAP4K3 4.35304505457969 3.10014573651358e-10 -0.23463272074259 0.495260619894842 miRanda;miRNATAP -0.143534323419065 8.12741594450168e-08 NA NA NA hsa-miR-155-5p MAP4K3 2.81443182173772 7.42530504828797e-05 -0.23463272074259 0.495260619894842 MirTarget -0.182429649900814 2.90467098946026e-12 NA NA NA hsa-miR-22-5p MAP4K3 2.38337850108621 1.0773503998394e-05 -0.23463272074259 0.495260619894842 MirTarget -0.100130836674524 0.0047517571026892 NA NA NA hsa-miR-342-3p MAP4K3 1.31107714473009 0.0207211910724662 -0.23463272074259 0.495260619894842 miRanda -0.201008364688123 1.91045806846729e-09 NA NA NA hsa-miR-590-3p MAP4K3 2.35429565068338 2.79601879608564e-06 -0.23463272074259 0.495260619894842 PITA;miRanda;mirMAP -0.128217260106624 0.000765554789884173 NA NA NA hsa-let-7c-5p MAP4K4 -2.03831836681378 0.0228401148731997 0.189998368969033 0.650968367170234 MirTarget -0.105098728161329 5.92467347714737e-05 NA NA NA hsa-let-7g-5p MAP4K4 0.857251702023746 0.00647597344297273 0.189998368969033 0.650968367170234 MirTarget -0.340917345392108 7.73597907840365e-06 NA NA NA hsa-miR-10a-5p MAP4K4 -0.482300926520507 0.594608783320466 0.189998368969033 0.650968367170234 MirTarget -0.129013084545712 5.57071319537031e-07 NA NA NA hsa-miR-10b-5p MAP4K4 -3.08172917642729 4.22675074435126e-09 0.189998368969033 0.650968367170234 MirTarget -0.143513317596033 0.00115595910268327 NA NA NA hsa-miR-200b-3p MAP4K4 5.56167217794639 6.43540045061709e-16 0.189998368969033 0.650968367170234 TargetScan -0.162844985995249 4.65126413003594e-07 NA NA NA hsa-miR-29c-3p MAP4K4 -0.414153610337085 0.529344128062017 0.189998368969033 0.650968367170234 miRNATAP -0.169098404288247 2.13293091282395e-06 NA NA NA hsa-miR-34a-5p MAP4K4 0.830377770217786 0.0477544831885907 0.189998368969033 0.650968367170234 MirTarget -0.222520994449405 8.86129164258511e-05 NA NA NA hsa-miR-429 MAP4K4 6.39965293994036 1.96920201593608e-18 0.189998368969033 0.650968367170234 PITA;miRanda;miRNATAP -0.103797929590627 0.000661537159526231 NA NA NA hsa-miR-148b-3p MAPK1 1.75622244535669 8.84414356040579e-08 0.0128019530419543 0.96439785606773 mirMAP -0.139901367015828 0.00442278516722453 NA NA NA hsa-miR-29b-2-5p MAPK1 -0.596051745078872 0.189540844841389 0.0128019530419543 0.96439785606773 mirMAP -0.150888486209755 2.15475742904008e-05 NA NA NA hsa-miR-29c-3p MAPK1 -0.414153610337085 0.529344128062017 0.0128019530419543 0.96439785606773 mirMAP -0.121961986993 4.61168241690927e-07 NA NA NA hsa-miR-30b-5p MAPK1 0.0238659735605804 0.953223658270319 0.0128019530419543 0.96439785606773 mirMAP -0.107494044816223 0.00753809874561411 NA NA NA hsa-miR-30e-5p MAPK1 0.780047227271616 0.0346714425913016 0.0128019530419543 0.96439785606773 mirMAP -0.116090988644527 0.00885887810727849 NA NA NA hsa-miR-3913-5p MAPK1 0.145645056779437 0.734844256690741 0.0128019530419543 0.96439785606773 mirMAP -0.108088444698366 0.00439552964093496 NA NA NA hsa-miR-130b-3p MAPK10 3.9204771543282 1.2714917955808e-11 -4.02861810775413 0.000455327611153647 miRNATAP -0.289477401545203 0.00852945933118219 NA NA NA hsa-miR-193a-3p MAPK10 0.646392169474854 0.207134343676122 -4.02861810775413 0.000455327611153647 miRanda;miRNATAP -0.422086807842181 0.00104846344400487 NA NA NA hsa-miR-19a-3p MAPK10 2.17020503944519 0.00122084653711062 -4.02861810775413 0.000455327611153647 miRNATAP -0.361656353314988 0.000189541931048248 NA NA NA hsa-miR-19b-3p MAPK10 1.67581705793313 0.000858910586302716 -4.02861810775413 0.000455327611153647 miRNATAP -0.607554128693399 2.5291087868802e-06 NA NA NA hsa-miR-301a-3p MAPK10 1.99338115332667 0.000813358604963724 -4.02861810775413 0.000455327611153647 miRNATAP -0.54512724483879 4.88085213693914e-07 NA NA NA hsa-miR-454-3p MAPK10 1.40269869979902 0.00366085847011367 -4.02861810775413 0.000455327611153647 miRNATAP -0.574589535977024 2.1903057455657e-05 NA NA NA hsa-miR-582-5p MAPK10 0.685177900016753 0.447761540297692 -4.02861810775413 0.000455327611153647 PITA -0.23346088711947 0.00130125193601691 NA NA NA hsa-miR-29a-5p MAPK8 0.0748295222568571 0.884125894063293 0.782437648754587 0.218394219235169 mirMAP -0.207086809669531 0.00336154577686051 NA NA NA hsa-miR-221-5p MAPK8IP1 2.07459535854377 0.0757339015356929 -2.05926002607344 0.032209907013751 MirTarget -0.194787104980288 3.06751212489886e-05 NA NA NA hsa-miR-24-3p MAPK8IP1 1.55853749533999 0.000524726461381821 -2.05926002607344 0.032209907013751 MirTarget;miRNATAP -0.472580210258139 9.44148706511976e-05 NA NA NA hsa-miR-330-5p MAPK8IP1 2.25110496739954 0.000275527655397415 -2.05926002607344 0.032209907013751 miRanda -0.460560978177516 9.23205646834053e-08 NA NA NA hsa-miR-10b-5p MAPK8IP3 -3.08172917642729 4.22675074435126e-09 0.379188836978613 0.351241723663493 mirMAP -0.12952174097798 0.0024989836738322 NA NA NA hsa-miR-128-3p MAPK8IP3 1.36248409467631 0.00408435995818078 0.379188836978613 0.351241723663493 MirTarget -0.13842458738706 0.00434966641592833 NA NA NA hsa-miR-324-3p MAPKAPK2 1.51345381556672 0.0038447546677657 0.0409801815001938 0.887998782758208 MirTarget -0.118424823700863 0.000138449265259097 NA NA NA hsa-miR-29a-5p MAPT 0.0748295222568571 0.884125894063293 -1.2459759498001 0.275681807811324 MirTarget;miRNATAP -0.42722175743793 0.000753838647623222 NA NA NA hsa-miR-31-5p MAPT 7.15600983164746 6.64190917357724e-10 -1.2459759498001 0.275681807811324 mirMAP -0.146896107432865 0.00666294931472834 NA NA NA hsa-miR-330-3p MAPT 2.49094236945806 0.000129367003214715 -1.2459759498001 0.275681807811324 mirMAP -0.31925003044628 0.0012322730219139 NA NA NA hsa-miR-484 MAPT 1.79050445056016 0.000217287101253701 -1.2459759498001 0.275681807811324 mirMAP -0.457833086712037 0.00058345250696208 NA NA NA hsa-miR-505-5p MAPT -0.548246528900629 0.331409094367131 -1.2459759498001 0.275681807811324 MirTarget -0.329899228955848 0.00422217779133849 NA NA NA hsa-miR-582-3p MAPT 0.280903327757368 0.772626550200977 -1.2459759498001 0.275681807811324 PITA;miRNATAP -0.268123819743866 4.99121480792537e-05 NA NA NA hsa-miR-7-1-3p MAPT 1.43074343339835 0.00471215970502094 -1.2459759498001 0.275681807811324 mirMAP -0.405595355366147 0.00152378994398221 NA NA NA hsa-miR-28-5p MAX -0.815636722979196 0.0221199948901761 -0.130167017533805 0.61670463632552 miRanda -0.152996842985482 0.000220772428880922 NA NA NA hsa-let-7a-3p MEF2C 0.82512001802525 0.0468122405194487 -3.76925742594602 1.08516088119004e-09 MirTarget;miRNATAP -0.285165237656199 0.00112850751510197 NA NA NA hsa-let-7f-1-3p MEF2C 1.61507869803314 0.00069342464777815 -3.76925742594602 1.08516088119004e-09 MirTarget -0.361637333574865 1.48350263535382e-06 NA NA NA hsa-let-7f-2-3p MEF2C 1.02768112108475 0.0787293499732611 -3.76925742594602 1.08516088119004e-09 mirMAP -0.176317520444159 0.00531478474932746 NA NA NA hsa-miR-103a-2-5p MEF2C 2.77240253557299 0.000302548514615442 -3.76925742594602 1.08516088119004e-09 MirTarget -0.206166155650611 9.99365747626211e-06 NA NA NA hsa-miR-107 MEF2C 1.49443409571439 0.000130594521065411 -3.76925742594602 1.08516088119004e-09 miRanda -0.311020966394855 0.000761316888393515 NA NA NA hsa-miR-125a-3p MEF2C -0.0748960586927341 0.920735897434087 -3.76925742594602 1.08516088119004e-09 MirTarget;PITA;miRanda -0.125372252457205 0.00906640229858486 NA NA NA hsa-miR-130a-5p MEF2C 1.58028512890005 0.024346333013728 -3.76925742594602 1.08516088119004e-09 MirTarget;miRNATAP -0.212671912886074 4.01770471992501e-05 NA NA NA hsa-miR-130b-5p MEF2C 3.74118449312296 2.92266550966038e-10 -3.76925742594602 1.08516088119004e-09 MirTarget;miRNATAP -0.352165588556263 1.02131733458118e-09 NA NA NA hsa-miR-135b-5p MEF2C 4.81084743274382 5.89180530843625e-08 -3.76925742594602 1.08516088119004e-09 MirTarget -0.174575464010168 9.04386114418849e-06 NA NA NA hsa-miR-182-5p MEF2C 5.86988712704738 1.22411588571584e-15 -3.76925742594602 1.08516088119004e-09 MirTarget;miRNATAP -0.254967572304038 2.74953650895146e-08 NA NA NA hsa-miR-183-5p MEF2C 6.61903249270777 1.00958881445636e-16 -3.76925742594602 1.08516088119004e-09 MirTarget;miRNATAP -0.252324227076538 1.64027532789906e-09 NA NA NA hsa-miR-188-5p MEF2C 1.39111178824125 0.0251592818948912 -3.76925742594602 1.08516088119004e-09 MirTarget;PITA -0.179328390139096 0.00205460302535171 NA NA NA hsa-miR-18a-3p MEF2C 3.64944956993027 7.20156641833731e-07 -3.76925742594602 1.08516088119004e-09 MirTarget;miRNATAP -0.251912471615618 1.17946509685298e-07 NA NA NA hsa-miR-18a-5p MEF2C 3.90770175770219 9.15298615034137e-10 -3.76925742594602 1.08516088119004e-09 MirTarget -0.314224877835983 5.25806509992162e-09 NA NA NA hsa-miR-19a-3p MEF2C 2.17020503944519 0.00122084653711062 -3.76925742594602 1.08516088119004e-09 miRNATAP -0.188145981692493 0.000402909988509694 NA NA NA hsa-miR-19b-3p MEF2C 1.67581705793313 0.000858910586302716 -3.76925742594602 1.08516088119004e-09 miRNATAP -0.341543692939979 1.36300545411905e-06 NA NA NA hsa-miR-200c-5p MEF2C 5.34093243595571 3.35355119348069e-10 -3.76925742594602 1.08516088119004e-09 MirTarget -0.425155693319067 4.02200753634414e-19 NA NA NA hsa-miR-203a-3p MEF2C 6.35084246337388 7.89944323347948e-08 -3.76925742594602 1.08516088119004e-09 MirTarget -0.14949244573991 3.26591218480776e-07 NA NA NA hsa-miR-20b-3p MEF2C 3.32857825638616 0.0632388433748268 -3.76925742594602 1.08516088119004e-09 MirTarget -0.171281883758667 1.01039858974251e-06 NA NA NA hsa-miR-223-3p MEF2C 2.27436751816553 0.00779697425178179 -3.76925742594602 1.08516088119004e-09 miRNAWalker2_validate;miRTarBase;MirTarget -0.111329879998109 0.00793337912738513 NA NA NA hsa-miR-224-3p MEF2C 2.84876340814503 0.000179138399939161 -3.76925742594602 1.08516088119004e-09 MirTarget;mirMAP -0.128757270626527 0.00648544469541514 NA NA NA hsa-miR-23a-3p MEF2C 0.925125296618358 0.0127293543936914 -3.76925742594602 1.08516088119004e-09 MirTarget;miRNATAP -0.367684121829885 0.000172308575320547 NA NA NA hsa-miR-26a-2-3p MEF2C 0.348140795080704 0.50914395378277 -3.76925742594602 1.08516088119004e-09 mirMAP -0.263626729259117 0.000119048691336438 NA NA NA hsa-miR-27a-3p MEF2C 1.76094007417453 0.000216137556256765 -3.76925742594602 1.08516088119004e-09 miRNATAP -0.343908750805233 4.23109336818357e-06 NA NA NA hsa-miR-3065-5p MEF2C 2.14185373842821 0.0609400502269891 -3.76925742594602 1.08516088119004e-09 MirTarget;mirMAP -0.164737949500325 2.23168796504393e-05 NA NA NA hsa-miR-30d-3p MEF2C -0.0740421896025512 0.857423650167556 -3.76925742594602 1.08516088119004e-09 MirTarget;miRNATAP -0.319567231381062 0.000296762630893492 NA NA NA hsa-miR-32-3p MEF2C 2.20477794939766 0.0392771274032852 -3.76925742594602 1.08516088119004e-09 mirMAP -0.230322664522529 9.44207300072227e-05 NA NA NA hsa-miR-324-3p MEF2C 1.51345381556672 0.0038447546677657 -3.76925742594602 1.08516088119004e-09 miRNATAP -0.324852487306261 1.78629943615345e-06 NA NA NA hsa-miR-331-5p MEF2C 1.02712086964089 0.0262526092356277 -3.76925742594602 1.08516088119004e-09 PITA -0.35176269179063 5.92911875061095e-06 NA NA NA hsa-miR-335-3p MEF2C 1.19503568251824 0.0938852560631551 -3.76925742594602 1.08516088119004e-09 MirTarget;mirMAP -0.177369819210299 0.000421184228850191 NA NA NA hsa-miR-33a-3p MEF2C 2.06269680799532 0.00156436055383943 -3.76925742594602 1.08516088119004e-09 MirTarget;mirMAP;miRNATAP -0.276187715290302 3.90379175030888e-07 NA NA NA hsa-miR-33b-5p MEF2C 4.77891217497671 1.33695107675057e-08 -3.76925742594602 1.08516088119004e-09 mirMAP -0.259838043311059 2.00884786503971e-10 NA NA NA hsa-miR-3613-5p MEF2C 4.05007522786126 4.52786477176299e-14 -3.76925742594602 1.08516088119004e-09 MirTarget;miRNATAP -0.261071607248705 4.62488904897457e-05 NA NA NA hsa-miR-425-5p MEF2C 3.15197291080781 3.16652350906107e-07 -3.76925742594602 1.08516088119004e-09 MirTarget;miRNATAP -0.327409657734089 5.90157189132826e-09 NA NA NA hsa-miR-429 MEF2C 6.39965293994036 1.96920201593608e-18 -3.76925742594602 1.08516088119004e-09 miRanda;miRNATAP -0.356079869721324 1.09569560252678e-15 NA NA NA hsa-miR-501-5p MEF2C 1.0411896821345 0.0777206709183552 -3.76925742594602 1.08516088119004e-09 MirTarget;PITA;miRNATAP -0.164220544068801 0.00729915704127695 NA NA NA hsa-miR-550a-3p MEF2C 2.59872127213466 0.00155498164206068 -3.76925742594602 1.08516088119004e-09 MirTarget -0.276482275745387 1.53121305635109e-07 NA NA NA hsa-miR-590-5p MEF2C 1.51400888103768 0.0023888567923017 -3.76925742594602 1.08516088119004e-09 MirTarget;PITA;miRanda;miRNATAP -0.317433734462764 9.41821638146254e-06 NA NA NA hsa-miR-744-3p MEF2C 1.08385719878174 0.131243679775541 -3.76925742594602 1.08516088119004e-09 MirTarget;miRNATAP -0.175805481878683 0.000435590345867152 NA NA NA hsa-miR-92a-3p MEF2C 1.87892405805529 1.27013821556583e-05 -3.76925742594602 1.08516088119004e-09 miRNAWalker2_validate -0.551876368066398 9.10470997397084e-12 NA NA NA hsa-miR-940 MEF2C 3.78496690968119 4.75227557809023e-05 -3.76925742594602 1.08516088119004e-09 PITA;miRNATAP -0.214670160050624 3.58935930481412e-06 NA NA NA hsa-miR-96-5p MEF2C 5.62521466029286 1.54938806718028e-10 -3.76925742594602 1.08516088119004e-09 miRNATAP -0.291401628285354 8.61489217004919e-10 NA NA NA hsa-miR-28-5p MKNK1 -0.815636722979196 0.0221199948901761 0.57662325838224 0.0370911588091397 miRanda -0.118866789149209 0.00754115103381623 NA NA NA hsa-miR-125a-5p MKNK2 -1.32352790615388 0.00714301627309467 0.871703291689258 0.0542925658462458 MirTarget -0.305432872422314 2.32516532943736e-09 NA NA NA hsa-miR-130b-5p MRAS 3.74118449312296 2.92266550966038e-10 -2.20743978476375 0.00313924651622258 mirMAP -0.181957216129013 0.00921269801182382 NA NA NA hsa-miR-33a-3p MRAS 2.06269680799532 0.00156436055383943 -2.20743978476375 0.00313924651622258 mirMAP -0.222813105290047 0.000618001153052767 NA NA NA hsa-miR-362-3p MRAS 0.679952485897744 0.226148468488576 -2.20743978476375 0.00313924651622258 miRanda -0.217435956226957 0.00442180876325086 NA NA NA hsa-miR-429 MRAS 6.39965293994036 1.96920201593608e-18 -2.20743978476375 0.00313924651622258 miRanda;miRNATAP -0.251691368075141 3.61623112540112e-06 NA NA NA hsa-miR-34a-5p MYC 0.830377770217786 0.0477544831885907 -0.745260197790044 0.453852120838847 miRNAWalker2_validate;miRTarBase -0.427487830189717 0.00161403194033986 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 6.39965293994036 1.96920201593608e-18 -0.745260197790044 0.453852120838847 miRNAWalker2_validate -0.351232938868747 9.84375821791447e-07 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-let-7a-3p NF1 0.82512001802525 0.0468122405194487 -0.117978195152688 0.760072550061892 mirMAP -0.154606728439517 0.00356408505375227 NA NA NA hsa-miR-142-3p NF1 4.35304505457969 3.10014573651358e-10 -0.117978195152688 0.760072550061892 miRanda -0.123255965384991 4.94543989551672e-05 NA NA NA hsa-miR-146b-5p NF1 1.87569569182453 0.000737241069698886 -0.117978195152688 0.760072550061892 miRanda -0.148072536353736 0.000139125360463492 NA NA NA hsa-miR-27a-3p NF1 1.76094007417453 0.000216137556256765 -0.117978195152688 0.760072550061892 MirTarget -0.147735243376854 0.00119833290646144 NA NA NA hsa-miR-27b-3p NF1 -0.0929089601968123 0.85847352206581 -0.117978195152688 0.760072550061892 MirTarget -0.137263300830972 0.00109147843527137 NA NA NA hsa-miR-29a-5p NF1 0.0748295222568571 0.884125894063293 -0.117978195152688 0.760072550061892 MirTarget;miRNATAP -0.126951902139221 0.00296858250464419 NA NA NA hsa-miR-30e-5p NF1 0.780047227271616 0.0346714425913016 -0.117978195152688 0.760072550061892 MirTarget;mirMAP -0.246441256016964 3.41868034048827e-05 NA NA NA hsa-miR-362-3p NF1 0.679952485897744 0.226148468488576 -0.117978195152688 0.760072550061892 miRanda -0.107911915883693 0.00577676516212844 NA NA NA hsa-miR-590-3p NF1 2.35429565068338 2.79601879608564e-06 -0.117978195152688 0.760072550061892 MirTarget;PITA;miRanda;miRNATAP -0.141115064459608 0.000987930333013466 NA NA NA hsa-miR-590-5p NF1 1.51400888103768 0.0023888567923017 -0.117978195152688 0.760072550061892 miRanda -0.122207819177215 0.00521632103243245 NA NA NA hsa-miR-16-2-3p NFATC2 3.79845098071094 1.49120139344659e-13 -0.286059700331541 0.82399568318191 mirMAP -0.505831882428398 0.000198875188682268 NA NA NA hsa-miR-182-5p NFATC2 5.86988712704738 1.22411588571584e-15 -0.286059700331541 0.82399568318191 mirMAP -0.32144165425718 0.000646026696926626 NA NA NA hsa-miR-19b-3p NFATC2 1.67581705793313 0.000858910586302716 -0.286059700331541 0.82399568318191 mirMAP -0.404387130112085 0.00521651290699105 NA NA NA hsa-miR-221-3p NFATC2 0.94082283577318 0.174749164179978 -0.286059700331541 0.82399568318191 MirTarget -0.377449174577961 0.000312614420924495 NA NA NA hsa-miR-222-3p NFATC2 1.54730827524553 0.0223014220569407 -0.286059700331541 0.82399568318191 MirTarget -0.397758818078019 0.000197967348333277 NA NA NA hsa-miR-2355-5p NFATC2 0.418226038913005 0.502149040287915 -0.286059700331541 0.82399568318191 MirTarget -0.399238734977261 0.000639415285590298 NA NA NA hsa-miR-24-3p NFATC2 1.55853749533999 0.000524726461381821 -0.286059700331541 0.82399568318191 MirTarget -0.468867821397621 0.00386071331628823 NA NA NA hsa-miR-26b-3p NFATC2 0.985177548213122 0.0351427970185971 -0.286059700331541 0.82399568318191 MirTarget -0.424161999476118 0.00685427841775268 NA NA NA hsa-miR-27b-5p NFATC2 0.213392605793392 0.71562473353293 -0.286059700331541 0.82399568318191 mirMAP -0.562887952208124 5.3203758057189e-06 NA NA NA hsa-miR-30b-5p NFATC2 0.0238659735605804 0.953223658270319 -0.286059700331541 0.82399568318191 MirTarget;mirMAP -0.701664889521975 0.000103150761633541 NA NA NA hsa-miR-335-3p NFATC2 1.19503568251824 0.0938852560631551 -0.286059700331541 0.82399568318191 mirMAP -0.275457201424799 0.00698833780307122 NA NA NA hsa-miR-33a-3p NFATC2 2.06269680799532 0.00156436055383943 -0.286059700331541 0.82399568318191 mirMAP -0.49218710815049 8.56348757093332e-06 NA NA NA hsa-miR-3607-3p NFATC2 1.38015131722213 0.0240067155694847 -0.286059700331541 0.82399568318191 MirTarget;mirMAP -0.391336207534776 0.000990733127382603 NA NA NA hsa-miR-590-3p NFATC2 2.35429565068338 2.79601879608564e-06 -0.286059700331541 0.82399568318191 mirMAP -0.384051398639096 0.00750996376662493 NA NA NA hsa-miR-9-5p NFATC2 1.79620806707734 0.14526963042518 -0.286059700331541 0.82399568318191 MirTarget -0.179640503569894 0.00223258011764884 NA NA NA hsa-miR-15b-3p NFATC4 3.57530146629867 5.89922785773482e-11 -3.51227827619475 3.3529829198664e-05 mirMAP -0.332671458598109 0.000109614721294728 NA NA NA hsa-miR-193a-3p NFATC4 0.646392169474854 0.207134343676122 -3.51227827619475 3.3529829198664e-05 miRanda -0.331963642605815 0.000483436127300785 NA NA NA hsa-miR-2355-5p NFATC4 0.418226038913005 0.502149040287915 -3.51227827619475 3.3529829198664e-05 MirTarget -0.222270601628068 0.00449762571989068 NA NA NA hsa-miR-29b-3p NFATC4 0.666547117072858 0.234055379278093 -3.51227827619475 3.3529829198664e-05 miRNATAP -0.269565814376398 0.0019545991736415 NA NA NA hsa-miR-484 NFATC4 1.79050445056016 0.000217287101253701 -3.51227827619475 3.3529829198664e-05 MirTarget;miRNATAP -0.333356851887072 0.000848337680097208 NA NA NA hsa-miR-629-3p NFATC4 3.48282157979573 4.9176538695908e-08 -3.51227827619475 3.3529829198664e-05 mirMAP -0.452159715701377 5.06669620050464e-10 NA NA NA hsa-let-7g-5p NGF 0.857251702023746 0.00647597344297273 -4.9479894848305 8.79599085267218e-05 MirTarget -0.75463687244667 0.00128893578106286 NA NA NA hsa-miR-429 NGF 6.39965293994036 1.96920201593608e-18 -4.9479894848305 8.79599085267218e-05 miRanda -0.370250673166168 6.50680322666926e-05 NA NA NA hsa-let-7b-5p NLK -0.189422992330471 0.651878220048983 0.183543839079865 0.498710830211101 miRNATAP -0.114257517524189 0.00186376055418449 NA NA NA hsa-let-7i-5p NLK 0.0473185312396307 0.869714142234765 0.183543839079865 0.498710830211101 miRNATAP -0.166463992572848 0.00230814976045761 NA NA NA hsa-miR-152-3p NLK 0.0996927696128376 0.867443498706607 0.183543839079865 0.498710830211101 MirTarget -0.100005908022808 8.57051397147721e-05 NA NA NA hsa-miR-221-3p NLK 0.94082283577318 0.174749164179978 0.183543839079865 0.498710830211101 MirTarget;miRNATAP -0.15407716283403 3.74272091558852e-13 NA NA NA hsa-miR-222-3p NLK 1.54730827524553 0.0223014220569407 0.183543839079865 0.498710830211101 MirTarget;miRNATAP -0.141074145632073 1.08276456992864e-10 NA NA NA hsa-miR-222-5p NLK 2.52056758362407 0.00142010793166944 0.183543839079865 0.498710830211101 MirTarget -0.122397786918054 5.03934994367364e-11 NA NA NA hsa-miR-23a-3p NLK 0.925125296618358 0.0127293543936914 0.183543839079865 0.498710830211101 miRNAWalker2_validate;MirTarget -0.111655445486474 0.00729490375203523 NA NA NA hsa-miR-27a-3p NLK 1.76094007417453 0.000216137556256765 0.183543839079865 0.498710830211101 miRNATAP -0.114442011738111 0.000322691345608444 NA NA NA hsa-miR-27b-3p NLK -0.0929089601968123 0.85847352206581 0.183543839079865 0.498710830211101 miRNATAP -0.105967873572703 0.000302277506931224 NA NA NA hsa-miR-342-3p NLK 1.31107714473009 0.0207211910724662 0.183543839079865 0.498710830211101 miRanda -0.124078682939925 3.10194434150662e-06 NA NA NA hsa-miR-26a-5p NRAS -0.352368463397074 0.362040749917446 1.25753065997981 5.62664778753041e-06 mirMAP;miRNATAP -0.172024479324 3.07852593374564e-05 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-28-5p NRAS -0.815636722979196 0.0221199948901761 1.25753065997981 5.62664778753041e-06 MirTarget;PITA;miRanda;miRNATAP -0.124303692945862 0.00588536888643892 NA NA NA hsa-miR-29c-3p NRAS -0.414153610337085 0.529344128062017 1.25753065997981 5.62664778753041e-06 miRNATAP -0.10862780456693 5.17574009803184e-06 NA NA NA hsa-miR-142-3p NTF3 4.35304505457969 3.10014573651358e-10 -3.48574436830551 0.00527602357381811 miRanda -0.264810182718392 0.00811224611096561 NA NA NA hsa-miR-21-5p NTF3 2.65163477806992 6.72089787690756e-16 -3.48574436830551 0.00527602357381811 miRTarBase;miRNATAP -0.72373377555354 0.000571440631212767 NA NA NA hsa-miR-107 NTRK2 1.49443409571439 0.000130594521065411 -1.54248853110693 0.400878993948488 PITA;miRanda -0.821688168341512 0.00210977706630013 NA NA NA hsa-miR-146b-5p NTRK2 1.87569569182453 0.000737241069698886 -1.54248853110693 0.400878993948488 PITA;miRanda -0.611776303657384 0.00101815416167714 NA NA NA hsa-miR-151a-5p NTRK2 1.0755926560327 0.00684662665520532 -1.54248853110693 0.400878993948488 miRNATAP -0.710685927254188 0.00718867606832889 NA NA NA hsa-miR-17-3p NTRK2 1.2477858204856 0.00186593270231258 -1.54248853110693 0.400878993948488 miRNATAP -1.0900436041431 2.63740736557872e-05 NA NA NA hsa-miR-200c-3p NTRK2 6.47012025883743 2.64500707716408e-26 -1.54248853110693 0.400878993948488 miRNAWalker2_validate;miRTarBase -0.454168801324507 0.00376453070732347 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-20a-3p NTRK2 1.9920766549842 0.000624458530894697 -1.54248853110693 0.400878993948488 mirMAP -0.54333551336232 0.00222970138095554 NA NA NA hsa-miR-3065-5p NTRK2 2.14185373842821 0.0609400502269891 -1.54248853110693 0.400878993948488 mirMAP -0.352023117959863 0.00183358469630041 NA NA NA hsa-miR-330-5p NTRK2 2.25110496739954 0.000275527655397415 -1.54248853110693 0.400878993948488 miRanda -0.525186837915093 0.00163346148640802 NA NA NA hsa-miR-335-3p NTRK2 1.19503568251824 0.0938852560631551 -1.54248853110693 0.400878993948488 mirMAP -0.787346785860579 3.85050756216982e-08 NA NA NA hsa-miR-338-3p NTRK2 0.447551118940466 0.558485097370031 -1.54248853110693 0.400878993948488 miRanda -0.558724956749295 3.55822561549528e-05 NA NA NA hsa-let-7i-5p PAK1 0.0473185312396307 0.869714142234765 0.311283860704987 0.3842246290012 miRNATAP -0.197968441083794 0.00628113196952742 NA NA NA hsa-miR-342-3p PAK1 1.31107714473009 0.0207211910724662 0.311283860704987 0.3842246290012 miRanda -0.158191458690312 7.31527767784086e-06 NA NA NA hsa-miR-29a-5p PAK2 0.0748295222568571 0.884125894063293 0.659609499303448 0.0301320715136705 mirMAP -0.104564991978069 0.00189029442635742 NA NA NA hsa-let-7g-5p PDGFB 0.857251702023746 0.00647597344297273 -1.35839055150716 0.0368647114422999 miRNATAP -0.402727711541148 0.000761785243186828 NA NA NA hsa-miR-29c-3p PDGFB -0.414153610337085 0.529344128062017 -1.35839055150716 0.0368647114422999 MirTarget;miRNATAP -0.222189266753565 7.03118101802513e-05 NA NA NA hsa-miR-342-3p PDGFB 1.31107714473009 0.0207211910724662 -1.35839055150716 0.0368647114422999 miRanda -0.234714756585261 0.000303525547934106 NA NA NA hsa-let-7a-3p PDGFRA 0.82512001802525 0.0468122405194487 -4.31615823709194 9.59580352063599e-06 mirMAP -0.431928097339744 0.00154173231192395 NA NA NA hsa-let-7f-1-3p PDGFRA 1.61507869803314 0.00069342464777815 -4.31615823709194 9.59580352063599e-06 mirMAP -0.666035412623016 9.51126490432519e-09 NA NA NA hsa-let-7g-3p PDGFRA 2.09736290930341 5.30067796437833e-05 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.385141069458271 0.000319714461007372 NA NA NA hsa-miR-106a-5p PDGFRA 3.98693608217557 9.37722470816656e-07 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.25960492629279 0.000115073753407648 NA NA NA hsa-miR-106b-5p PDGFRA 2.80565545918114 1.14547999022566e-09 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.783177330311627 1.33145452797817e-11 NA NA NA hsa-miR-130b-3p PDGFRA 3.9204771543282 1.2714917955808e-11 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.427321315908455 4.17207041632257e-06 NA NA NA hsa-miR-141-3p PDGFRA 7.30474126597325 1.45115996357606e-24 -4.31615823709194 9.59580352063599e-06 MirTarget -0.459303779088419 7.19932671476961e-11 NA NA NA hsa-miR-16-1-3p PDGFRA 2.83281226969693 7.54359864580834e-09 -4.31615823709194 9.59580352063599e-06 MirTarget -0.700660080272716 1.49692189146508e-10 NA NA NA hsa-miR-17-5p PDGFRA 2.3269271449522 2.13987445663942e-05 -4.31615823709194 9.59580352063599e-06 MirTarget;TargetScan;miRNATAP -0.640106894332429 9.36070480923555e-11 NA NA NA hsa-miR-182-5p PDGFRA 5.86988712704738 1.22411588571584e-15 -4.31615823709194 9.59580352063599e-06 miRNATAP -0.317289848753412 1.07869714551322e-05 NA NA NA hsa-miR-193a-3p PDGFRA 0.646392169474854 0.207134343676122 -4.31615823709194 9.59580352063599e-06 miRanda -0.504497245228834 3.66276149701725e-06 NA NA NA hsa-miR-196a-5p PDGFRA 2.71653705877687 0.0233843546205134 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.15397255400863 0.000904257469932413 NA NA NA hsa-miR-200a-3p PDGFRA 6.336081120041 4.024313571871e-16 -4.31615823709194 9.59580352063599e-06 MirTarget -0.2276447486551 0.000847664710398646 NA NA NA hsa-miR-20a-5p PDGFRA 2.13553469875764 0.000181201072324354 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.567299949346882 2.96977674996385e-09 NA NA NA hsa-miR-20b-5p PDGFRA 4.5662923200279 4.75238200639144e-05 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.130673579448784 0.00796359807809751 NA NA NA hsa-miR-2110 PDGFRA 1.8070969695103 0.00137196847440523 -4.31615823709194 9.59580352063599e-06 MirTarget -0.294307403934914 0.00362701551176569 NA NA NA hsa-miR-219a-5p PDGFRA 0.993473018224215 0.125519257191974 -4.31615823709194 9.59580352063599e-06 MirTarget -0.329204993675169 0.000180641355808018 NA NA NA hsa-miR-224-5p PDGFRA 4.2725754042941 6.99983365278436e-06 -4.31615823709194 9.59580352063599e-06 MirTarget -0.180983373061526 0.00177407515227038 NA NA NA hsa-miR-24-3p PDGFRA 1.55853749533999 0.000524726461381821 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.557629319889882 6.60110927772163e-06 NA NA NA hsa-miR-27a-3p PDGFRA 1.76094007417453 0.000216137556256765 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.541698361583472 3.22811351990072e-06 NA NA NA hsa-miR-301a-3p PDGFRA 1.99338115332667 0.000813358604963724 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.319823844411805 0.000624462369659605 NA NA NA hsa-miR-330-5p PDGFRA 2.25110496739954 0.000275527655397415 -4.31615823709194 9.59580352063599e-06 miRanda -0.279887405553284 0.00184527634111128 NA NA NA hsa-miR-335-3p PDGFRA 1.19503568251824 0.0938852560631551 -4.31615823709194 9.59580352063599e-06 mirMAP -0.399011852951966 2.54729494558275e-07 NA NA NA hsa-miR-339-5p PDGFRA 1.23326828594484 0.0307501214818698 -4.31615823709194 9.59580352063599e-06 miRanda -0.445649150056303 4.71947718860255e-06 NA NA NA hsa-miR-33a-5p PDGFRA 2.60046838991599 0.000472459723448608 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.401227415359423 4.68699510138077e-08 NA NA NA hsa-miR-33b-5p PDGFRA 4.77891217497671 1.33695107675057e-08 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.417676719939801 4.62228731851437e-11 NA NA NA hsa-miR-421 PDGFRA 1.97624148591545 0.000915838012451138 -4.31615823709194 9.59580352063599e-06 PITA;miRanda;miRNATAP -0.261259988987499 0.005444760084744 NA NA NA hsa-miR-429 PDGFRA 6.39965293994036 1.96920201593608e-18 -4.31615823709194 9.59580352063599e-06 miRanda;miRNATAP -0.246069016468543 0.000645893632657437 NA NA NA hsa-miR-454-3p PDGFRA 1.40269869979902 0.00366085847011367 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.456035002792179 8.16868294338271e-05 NA NA NA hsa-miR-550a-5p PDGFRA 1.21781238856895 0.0613791144699551 -4.31615823709194 9.59580352063599e-06 MirTarget -0.330426749632516 0.000118451208040612 NA NA NA hsa-miR-576-5p PDGFRA 1.30320223793746 0.00648929463912994 -4.31615823709194 9.59580352063599e-06 mirMAP -0.566981132043652 1.0311095468956e-06 NA NA NA hsa-miR-589-3p PDGFRA 1.33205316880069 0.052632683806148 -4.31615823709194 9.59580352063599e-06 mirMAP -0.292397869554739 0.000347972467306377 NA NA NA hsa-miR-590-3p PDGFRA 2.35429565068338 2.79601879608564e-06 -4.31615823709194 9.59580352063599e-06 miRanda;mirMAP -0.486413160870772 8.89956355896103e-06 NA NA NA hsa-miR-590-5p PDGFRA 1.51400888103768 0.0023888567923017 -4.31615823709194 9.59580352063599e-06 miRanda -0.571701323857916 2.55352789240418e-07 NA NA NA hsa-miR-616-5p PDGFRA 2.48416313933027 0.00318247475868827 -4.31615823709194 9.59580352063599e-06 mirMAP -0.288805433307288 0.000485679968015046 NA NA NA hsa-miR-7-1-3p PDGFRA 1.43074343339835 0.00471215970502094 -4.31615823709194 9.59580352063599e-06 mirMAP -0.298820288824693 0.0071101303035319 NA NA NA hsa-miR-93-5p PDGFRA 2.65964181833033 2.58315947526774e-08 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.64786722499128 1.07665753473659e-08 NA NA NA hsa-miR-944 PDGFRA 7.20925181386398 0.000823207457340648 -4.31615823709194 9.59580352063599e-06 mirMAP -0.148526701539017 2.75742723317954e-06 NA NA NA hsa-miR-96-5p PDGFRA 5.62521466029286 1.54938806718028e-10 -4.31615823709194 9.59580352063599e-06 TargetScan;miRNATAP -0.397453542320597 9.60638780124384e-08 NA NA NA hsa-miR-224-5p PDGFRB 4.2725754042941 6.99983365278436e-06 -3.00627214348519 7.34667780692721e-05 miRNAWalker2_validate -0.146201861578625 0.00110933147204739 NA NA NA hsa-miR-34a-5p PDGFRB 0.830377770217786 0.0477544831885907 -3.00627214348519 7.34667780692721e-05 MirTarget -0.312602617436571 0.00280746999217784 24837198 MicroRNA 34A inhibits the growth invasion and metastasis of gastric cancer by targeting PDGFR and MET expression; In this study our aim was to identify the miRNAs that target PDGFR-α/β and to study the functions of these miRNAs miR-34a was predicted to target PDGFR and luciferase reporter assays showed that miR-34a could directly target PDGFR; Moreover the cancer-associated cell signalling pathway was studied and we found that miR-34a could inhibit Akt PKB protein kinase B phosphorylation which was restored by the overexpression of both PDGFR and MET; In conclusion miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K phosphoinositide 3-kinase/Akt pathway metastasis gastric cancer hsa-miR-361-3p PDGFRB 0.805698609170807 0.0418491665498322 -3.00627214348519 7.34667780692721e-05 MirTarget -0.366005767450926 0.000965550104549401 NA NA NA hsa-miR-484 PDGFRB 1.79050445056016 0.000217287101253701 -3.00627214348519 7.34667780692721e-05 mirMAP -0.32636125869027 0.00025262001509626 NA NA NA hsa-miR-142-3p PLA2G12A 4.35304505457969 3.10014573651358e-10 -0.348931284411703 0.228360506827383 miRanda -0.10322065696675 5.11675789428433e-06 NA NA NA hsa-miR-142-5p PLA2G12A 3.95552531913424 1.49536283724079e-08 -0.348931284411703 0.228360506827383 mirMAP -0.125434802427425 1.99725477945959e-08 NA NA NA hsa-miR-491-5p PLA2G2A 0.569358547192776 0.313310594748302 -3.35004246895337 0.0852880829350494 miRanda -0.56271081292586 0.00482974128542031 NA NA NA hsa-miR-125a-5p PLA2G2F -1.32352790615388 0.00714301627309467 4.61318022259117 0.0169435167136214 mirMAP -1.06452110955483 1.51556404188548e-06 NA NA NA hsa-miR-125b-5p PLA2G2F -2.01187572101832 0.00516480893645494 4.61318022259117 0.0169435167136214 mirMAP -0.40347317100202 0.00803625949584725 NA NA NA hsa-miR-324-3p PLA2G2F 1.51345381556672 0.0038447546677657 4.61318022259117 0.0169435167136214 mirMAP -0.655625739442234 0.00177309107493498 NA NA NA hsa-miR-335-5p PLA2G2F 0.167216045757305 0.803897055331049 4.61318022259117 0.0169435167136214 mirMAP -0.470559276052835 0.00402796787980824 NA NA NA hsa-let-7e-5p PLA2G3 -0.111012524740586 0.814744515884005 5.30782171549448 0.00470136493378772 MirTarget -0.83647950156538 0.000230679406013596 NA NA NA hsa-miR-125a-3p PLA2G3 -0.0748960586927341 0.920735897434087 5.30782171549448 0.00470136493378772 miRanda;miRNATAP -0.512587256488481 0.00030751805191174 NA NA NA hsa-miR-32-3p PLA2G3 2.20477794939766 0.0392771274032852 5.30782171549448 0.00470136493378772 miRNATAP -0.599678039838321 0.000646345923075148 NA NA NA hsa-miR-590-3p PLA2G4A 2.35429565068338 2.79601879608564e-06 -1.18655189146257 0.318420995084282 miRanda -0.356477543361995 0.00732189671160126 NA NA NA hsa-miR-2355-3p PLA2G6 0.494099635633886 0.483724014019781 0.0372700921853339 0.944252191933756 MirTarget -0.224599201216566 9.75788647461578e-08 NA NA NA hsa-let-7g-3p PPM1A 2.09736290930341 5.30067796437833e-05 -0.624953663745068 0.00862705774679663 miRNATAP -0.104181310853226 4.32067774944642e-05 NA NA NA hsa-miR-146b-3p PPM1A 1.34608871980101 0.00935728391852709 -0.624953663745068 0.00862705774679663 miRNATAP -0.137218874535542 7.11871924112966e-08 NA NA NA hsa-miR-146b-5p PPM1A 1.87569569182453 0.000737241069698886 -0.624953663745068 0.00862705774679663 miRanda;miRNATAP -0.12873878989287 4.88238892851075e-08 NA NA NA hsa-miR-186-5p PPM1A 0.445443449112564 0.185447310527704 -0.624953663745068 0.00862705774679663 mirMAP;miRNATAP -0.185429592901921 4.19010316069248e-06 NA NA NA hsa-miR-26b-5p PPM1A 0.314414148564179 0.461628303578321 -0.624953663745068 0.00862705774679663 mirMAP -0.115444487408403 0.000261159294154392 NA NA NA hsa-miR-34a-5p PPM1A 0.830377770217786 0.0477544831885907 -0.624953663745068 0.00862705774679663 miRNATAP -0.113228244661606 0.000428299563806515 NA NA NA hsa-miR-484 PPM1A 1.79050445056016 0.000217287101253701 -0.624953663745068 0.00862705774679663 miRNAWalker2_validate -0.11893835291918 1.37936912568807e-05 NA NA NA hsa-miR-590-3p PPM1A 2.35429565068338 2.79601879608564e-06 -0.624953663745068 0.00862705774679663 miRanda;mirMAP -0.117024707052139 7.55666307083652e-06 NA NA NA hsa-miR-342-3p PPM1B 1.31107714473009 0.0207211910724662 -0.414403455973409 0.117381804949489 miRanda -0.106036414446897 4.82257092968814e-05 NA NA NA hsa-let-7g-5p PPP3CA 0.857251702023746 0.00647597344297273 -0.0994691469518081 0.767527156115313 miRNATAP -0.161347150543761 0.00879795113322894 NA NA NA hsa-let-7a-3p PRKACB 0.82512001802525 0.0468122405194487 -1.46896806095161 0.00691161548744777 MirTarget;mirMAP;miRNATAP -0.212227756129949 0.00484060334729975 NA NA NA hsa-miR-141-3p PRKACB 7.30474126597325 1.45115996357606e-24 -1.46896806095161 0.00691161548744777 MirTarget;TargetScan;miRNATAP -0.179713976485568 5.50509722074074e-06 NA NA NA hsa-miR-16-2-3p PRKACB 3.79845098071094 1.49120139344659e-13 -1.46896806095161 0.00691161548744777 mirMAP -0.256987391063205 7.64721558586313e-06 NA NA NA hsa-miR-17-5p PRKACB 2.3269271449522 2.13987445663942e-05 -1.46896806095161 0.00691161548744777 TargetScan -0.147030961972885 0.00870649595844882 NA NA NA hsa-miR-182-5p PRKACB 5.86988712704738 1.22411588571584e-15 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.137741652786639 0.000572629355125557 NA NA NA hsa-miR-183-5p PRKACB 6.61903249270777 1.00958881445636e-16 -1.46896806095161 0.00691161548744777 MirTarget -0.125680903296988 0.000602029705127091 NA NA NA hsa-miR-18a-5p PRKACB 3.90770175770219 9.15298615034137e-10 -1.46896806095161 0.00691161548744777 miRNATAP -0.147626596716624 0.00172397395444837 NA NA NA hsa-miR-193a-3p PRKACB 0.646392169474854 0.207134343676122 -1.46896806095161 0.00691161548744777 miRanda -0.257394862253127 1.9252355211219e-05 NA NA NA hsa-miR-19a-3p PRKACB 2.17020503944519 0.00122084653711062 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.131490327577289 0.0040920531186784 NA NA NA hsa-miR-19b-3p PRKACB 1.67581705793313 0.000858910586302716 -1.46896806095161 0.00691161548744777 miRNAWalker2_validate;MirTarget;miRNATAP -0.191193316637283 0.00183404785527112 NA NA NA hsa-miR-200a-3p PRKACB 6.336081120041 4.024313571871e-16 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.104144124001908 0.00576356163422443 NA NA NA hsa-miR-200c-3p PRKACB 6.47012025883743 2.64500707716408e-26 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.145130591541329 0.00181365494045828 NA NA NA hsa-miR-3065-5p PRKACB 2.14185373842821 0.0609400502269891 -1.46896806095161 0.00691161548744777 MirTarget -0.128827162641901 0.000116356569225078 NA NA NA hsa-miR-429 PRKACB 6.39965293994036 1.96920201593608e-18 -1.46896806095161 0.00691161548744777 MirTarget;PITA;miRanda;miRNATAP -0.108770954611392 0.00641118010678973 NA NA NA hsa-miR-93-5p PRKACB 2.65964181833033 2.58315947526774e-08 -1.46896806095161 0.00691161548744777 miRNAWalker2_validate -0.1828758599464 0.00409856289818273 NA NA NA hsa-miR-96-5p PRKACB 5.62521466029286 1.54938806718028e-10 -1.46896806095161 0.00691161548744777 miRNATAP -0.17033105097326 3.99524226143001e-05 NA NA NA hsa-miR-142-5p PRKCA 3.95552531913424 1.49536283724079e-08 -2.51484065178579 0.000301846026330391 mirMAP -0.157985182568495 0.00450284307697346 NA NA NA hsa-miR-183-5p PRKCA 6.61903249270777 1.00958881445636e-16 -2.51484065178579 0.000301846026330391 miRNATAP -0.195964689338451 2.96312561009603e-05 NA NA NA hsa-miR-200c-3p PRKCA 6.47012025883743 2.64500707716408e-26 -2.51484065178579 0.000301846026330391 miRNATAP -0.227644911192639 0.000134967313056447 NA NA NA hsa-miR-30e-3p PRKCA -0.0362193022195196 0.932577027239525 -2.51484065178579 0.000301846026330391 mirMAP -0.330264937460595 0.000431865199778726 NA NA NA hsa-miR-330-3p PRKCA 2.49094236945806 0.000129367003214715 -2.51484065178579 0.000301846026330391 mirMAP -0.173880498227238 0.0042321147753766 NA NA NA hsa-miR-340-5p PRKCA 1.41210478721579 0.00958612942879818 -2.51484065178579 0.000301846026330391 mirMAP -0.247780249808726 0.000683356782218492 NA NA NA hsa-miR-374a-3p PRKCA 0.465360399099794 0.305267458251279 -2.51484065178579 0.000301846026330391 mirMAP -0.324087022951615 0.000236966482552477 NA NA NA hsa-miR-374a-5p PRKCA 0.278549982012055 0.45888283715888 -2.51484065178579 0.000301846026330391 mirMAP -0.315860192203564 0.00334938709870334 NA NA NA hsa-miR-590-3p PRKCA 2.35429565068338 2.79601879608564e-06 -2.51484065178579 0.000301846026330391 PITA;miRanda;mirMAP;miRNATAP -0.344157378397527 9.41463074505618e-06 NA NA NA hsa-miR-9-5p PRKCA 1.79620806707734 0.14526963042518 -2.51484065178579 0.000301846026330391 miRNATAP -0.102263861653536 0.00143068318206041 NA NA NA hsa-miR-944 PRKCA 7.20925181386398 0.000823207457340648 -2.51484065178579 0.000301846026330391 PITA;miRNATAP -0.163061119524878 9.18211721568101e-14 NA NA NA hsa-miR-129-5p PRKCB -2.66843722411409 0.00695783358331245 -1.37779465994896 0.125783325051528 miRanda;mirMAP -0.148528580809065 0.00435751368999719 NA NA NA hsa-miR-130a-5p PRKCB 1.58028512890005 0.024346333013728 -1.37779465994896 0.125783325051528 mirMAP -0.212100504604163 0.00409650973476373 NA NA NA hsa-miR-141-5p PRKCB 7.13744624551943 4.06877058732583e-26 -1.37779465994896 0.125783325051528 mirMAP -0.19239678572128 0.00558256661173632 NA NA NA hsa-miR-200b-3p PRKCB 5.56167217794639 6.43540045061709e-16 -1.37779465994896 0.125783325051528 MirTarget -0.301150868895001 1.67192981795653e-05 NA NA NA hsa-miR-200c-3p PRKCB 6.47012025883743 2.64500707716408e-26 -1.37779465994896 0.125783325051528 MirTarget;miRNATAP -0.348745791831867 4.59454351785762e-06 NA NA NA hsa-miR-24-3p PRKCB 1.55853749533999 0.000524726461381821 -1.37779465994896 0.125783325051528 miRNATAP -0.348466036252195 0.00216084517312112 NA NA NA hsa-miR-30d-3p PRKCB -0.0740421896025512 0.857423650167556 -1.37779465994896 0.125783325051528 mirMAP -0.466704414757516 0.000189785701017437 NA NA NA hsa-miR-335-3p PRKCB 1.19503568251824 0.0938852560631551 -1.37779465994896 0.125783325051528 mirMAP -0.319943845988664 6.21148850866805e-06 NA NA NA hsa-miR-335-5p PRKCB 0.167216045757305 0.803897055331049 -1.37779465994896 0.125783325051528 mirMAP -0.264751633170281 0.000471558920124749 NA NA NA hsa-miR-429 PRKCB 6.39965293994036 1.96920201593608e-18 -1.37779465994896 0.125783325051528 MirTarget;miRanda;miRNATAP -0.361917851736747 2.11441310702277e-08 NA NA NA hsa-miR-589-3p PRKCB 1.33205316880069 0.052632683806148 -1.37779465994896 0.125783325051528 mirMAP -0.256370688506043 0.000574321239976677 NA NA NA hsa-miR-590-5p PRKCB 1.51400888103768 0.0023888567923017 -1.37779465994896 0.125783325051528 miRanda -0.299520538968311 0.00345339662465929 NA NA NA hsa-miR-9-3p PRKCB 1.69328215716742 0.125170982657059 -1.37779465994896 0.125783325051528 mirMAP -0.175906285304137 0.000158783736278398 NA NA NA hsa-miR-130a-5p PRKX 1.58028512890005 0.024346333013728 2.17507999383594 0.000704686070863552 mirMAP -0.187730727746443 0.00038419514315305 NA NA NA hsa-miR-148b-3p PRKX 1.75622244535669 8.84414356040579e-08 2.17507999383594 0.000704686070863552 MirTarget -0.306982570800927 0.00606517379097925 NA NA NA hsa-miR-335-3p PRKX 1.19503568251824 0.0938852560631551 2.17507999383594 0.000704686070863552 mirMAP -0.162862473837577 0.00148982890472507 NA NA NA hsa-miR-335-5p PTPN7 0.167216045757305 0.803897055331049 1.17963330919888 0.151774286835026 miRNAWalker2_validate -0.247628759682953 0.000344729994830904 NA NA NA hsa-miR-150-5p PTPRR 1.76769157530064 0.0593795975117846 -3.71280638045582 0.0171846064138326 miRNAWalker2_validate -0.371867224442694 7.12199119230871e-05 NA NA NA hsa-miR-16-1-3p PTPRR 2.83281226969693 7.54359864580834e-09 -3.71280638045582 0.0171846064138326 MirTarget -0.53690204138668 0.00247381947434674 NA NA NA hsa-miR-590-3p PTPRR 2.35429565068338 2.79601879608564e-06 -3.71280638045582 0.0171846064138326 miRanda -0.491825457837804 0.00488632098626384 NA NA NA hsa-miR-374a-5p RAC1 0.278549982012055 0.45888283715888 0.0440982372971011 0.900045954349393 mirMAP -0.140356402054542 0.00882655342567711 NA NA NA hsa-miR-450b-5p RAC1 0.445103105471153 0.416021465008949 0.0440982372971011 0.900045954349393 mirMAP -0.108599310907085 0.00278942668689792 NA NA NA hsa-miR-129-5p RAC2 -2.66843722411409 0.00695783358331245 1.63571810371488 0.0215946836435966 miRanda -0.123304880787715 0.00280670600839041 NA NA NA hsa-miR-125a-5p RAP1A -1.32352790615388 0.00714301627309467 -0.57841259597687 0.0321953876339051 miRanda -0.106871059532972 0.000543946745685066 NA NA NA hsa-miR-19b-3p RAP1A 1.67581705793313 0.000858910586302716 -0.57841259597687 0.0321953876339051 MirTarget;miRNATAP -0.103592257469625 0.000586234161503712 NA NA NA hsa-miR-3913-5p RAP1A 0.145645056779437 0.734844256690741 -0.57841259597687 0.0321953876339051 mirMAP -0.110635962023894 0.00198924939736687 NA NA NA hsa-miR-30e-5p RAP1B 0.780047227271616 0.0346714425913016 -0.674003222552351 0.00985147819812677 MirTarget -0.15568246601355 0.000110596078056289 NA NA NA hsa-miR-149-5p RAPGEF2 1.18551753240939 0.197439607622379 -0.848933745143619 0.030186097225232 miRNAWalker2_validate -0.110455788995587 3.44708422800395e-06 NA NA NA hsa-miR-155-5p RAPGEF2 2.81443182173772 7.42530504828797e-05 -0.848933745143619 0.030186097225232 miRNAWalker2_validate;MirTarget -0.149371652726129 9.56406953087437e-07 NA NA NA hsa-miR-15b-5p RAPGEF2 3.32329949959268 8.40210501034588e-13 -0.848933745143619 0.030186097225232 miRNATAP -0.136586353763295 0.003139307182147 NA NA NA hsa-miR-193a-3p RAPGEF2 0.646392169474854 0.207134343676122 -0.848933745143619 0.030186097225232 miRanda -0.169621554291742 8.92474255247109e-05 NA NA NA hsa-miR-27a-3p RAPGEF2 1.76094007417453 0.000216137556256765 -0.848933745143619 0.030186097225232 MirTarget;miRNATAP -0.159816931758792 0.000566621742658434 NA NA NA hsa-miR-27b-3p RAPGEF2 -0.0929089601968123 0.85847352206581 -0.848933745143619 0.030186097225232 MirTarget;miRNATAP -0.128126293007605 0.00277859693863964 NA NA NA hsa-miR-30e-3p RAPGEF2 -0.0362193022195196 0.932577027239525 -0.848933745143619 0.030186097225232 MirTarget -0.148574187189455 0.00463477711162402 NA NA NA hsa-miR-339-5p RAPGEF2 1.23326828594484 0.0307501214818698 -0.848933745143619 0.030186097225232 MirTarget;PITA -0.151661459791301 8.7712629771862e-05 NA NA NA hsa-miR-33a-3p RAPGEF2 2.06269680799532 0.00156436055383943 -0.848933745143619 0.030186097225232 mirMAP -0.134335103548338 6.95943916384937e-05 NA NA NA hsa-miR-374b-5p RAPGEF2 -0.114749866169918 0.764888930049438 -0.848933745143619 0.030186097225232 mirMAP -0.193718552622575 0.000959622004267299 NA NA NA hsa-miR-590-3p RAPGEF2 2.35429565068338 2.79601879608564e-06 -0.848933745143619 0.030186097225232 miRanda -0.185476918962144 1.86955738682492e-05 NA NA NA hsa-miR-30a-5p RASA1 -0.768430903969183 0.320487552854215 -0.379904300224513 0.406248459295642 MirTarget;miRNATAP -0.115222034967575 0.000541243096815849 NA NA NA hsa-miR-320c RASA1 -0.10618808730545 0.854002814666472 -0.379904300224513 0.406248459295642 MirTarget;PITA;miRanda;miRNATAP -0.129089439276561 0.00487560967237353 NA NA NA hsa-miR-33b-5p RASA1 4.77891217497671 1.33695107675057e-08 -0.379904300224513 0.406248459295642 miRNATAP -0.110179314057177 0.000233919189732168 NA NA NA hsa-miR-590-3p RASA1 2.35429565068338 2.79601879608564e-06 -0.379904300224513 0.406248459295642 miRanda -0.152692162464424 0.00269852727946498 NA NA NA hsa-miR-374b-5p RASA2 -0.114749866169918 0.764888930049438 1.30305025876205 0.0993202174227608 mirMAP -0.343589799660423 0.00385130199518223 NA NA NA hsa-miR-589-3p RASA2 1.33205316880069 0.052632683806148 1.30305025876205 0.0993202174227608 mirMAP -0.174626304423742 0.00782699836376741 NA NA NA hsa-miR-106a-5p RASGRF2 3.98693608217557 9.37722470816656e-07 -2.9068173867099 5.9508387011546e-05 MirTarget -0.246522930489663 6.06782032266057e-07 NA NA NA hsa-miR-106b-5p RASGRF2 2.80565545918114 1.14547999022566e-09 -2.9068173867099 5.9508387011546e-05 MirTarget -0.425105775462409 1.08336004178415e-06 NA NA NA hsa-miR-17-5p RASGRF2 2.3269271449522 2.13987445663942e-05 -2.9068173867099 5.9508387011546e-05 MirTarget;TargetScan -0.310390190858724 3.16599665233085e-05 NA NA NA hsa-miR-182-5p RASGRF2 5.86988712704738 1.22411588571584e-15 -2.9068173867099 5.9508387011546e-05 mirMAP -0.192234284962812 0.000338100465852347 NA NA NA hsa-miR-20a-5p RASGRF2 2.13553469875764 0.000181201072324354 -2.9068173867099 5.9508387011546e-05 MirTarget -0.308298398010268 1.71361970887382e-05 NA NA NA hsa-miR-20b-5p RASGRF2 4.5662923200279 4.75238200639144e-05 -2.9068173867099 5.9508387011546e-05 MirTarget -0.124789015595148 0.000586296305883246 NA NA NA hsa-miR-224-5p RASGRF2 4.2725754042941 6.99983365278436e-06 -2.9068173867099 5.9508387011546e-05 MirTarget -0.146705591114202 0.000604679049023023 NA NA NA hsa-miR-3065-5p RASGRF2 2.14185373842821 0.0609400502269891 -2.9068173867099 5.9508387011546e-05 mirMAP -0.132321937216197 0.00334417878321228 NA NA NA hsa-miR-30d-3p RASGRF2 -0.0740421896025512 0.857423650167556 -2.9068173867099 5.9508387011546e-05 mirMAP -0.265390403960918 0.00946377582626332 NA NA NA hsa-miR-429 RASGRF2 6.39965293994036 1.96920201593608e-18 -2.9068173867099 5.9508387011546e-05 miRanda -0.292435755323417 2.61879463979305e-08 NA NA NA hsa-miR-590-5p RASGRF2 1.51400888103768 0.0023888567923017 -2.9068173867099 5.9508387011546e-05 miRanda -0.239840521933126 0.00398929447121354 NA NA NA hsa-miR-93-5p RASGRF2 2.65964181833033 2.58315947526774e-08 -2.9068173867099 5.9508387011546e-05 MirTarget -0.411477966688014 1.10045529361831e-06 NA NA NA hsa-let-7e-5p RASGRP1 -0.111012524740586 0.814744515884005 2.23400263469339 0.0139630973843187 MirTarget;miRNATAP -0.433666461063836 7.48256112863431e-05 NA NA NA hsa-miR-196a-5p RASGRP1 2.71653705877687 0.0233843546205134 2.23400263469339 0.0139630973843187 MirTarget;miRNATAP -0.165103821918358 0.000107330445663081 NA NA NA hsa-miR-196b-5p RASGRP1 -0.103579538052452 0.859017000109845 2.23400263469339 0.0139630973843187 MirTarget;miRNATAP -0.243349121009759 0.00632586147552784 NA NA NA hsa-miR-30a-3p RASGRP1 -1.22212086897848 0.167565797592104 2.23400263469339 0.0139630973843187 MirTarget -0.258771356750651 7.28244070036944e-06 NA NA NA hsa-miR-30d-3p RASGRP1 -0.0740421896025512 0.857423650167556 2.23400263469339 0.0139630973843187 MirTarget -0.44424475636379 0.000460349405821391 NA NA NA hsa-miR-320b RASGRP1 0.20205459771295 0.727216419960509 2.23400263469339 0.0139630973843187 miRanda -0.247206364547654 0.00586423793029181 NA NA NA hsa-miR-335-5p RASGRP1 0.167216045757305 0.803897055331049 2.23400263469339 0.0139630973843187 miRNAWalker2_validate -0.429212218580283 1.28588907323207e-08 NA NA NA hsa-miR-429 RASGRP1 6.39965293994036 1.96920201593608e-18 2.23400263469339 0.0139630973843187 miRanda -0.202854963511338 0.00232329893212606 NA NA NA hsa-miR-324-3p RASGRP2 1.51345381556672 0.0038447546677657 -3.56791420156745 1.89987092111788e-05 PITA -0.505380908738257 1.84893714445332e-08 NA NA NA hsa-miR-940 RASGRP2 3.78496690968119 4.75227557809023e-05 -3.56791420156745 1.89987092111788e-05 MirTarget;PITA;miRNATAP -0.336189706682162 3.93654770743004e-08 NA NA NA hsa-miR-28-5p RASGRP3 -0.815636722979196 0.0221199948901761 -1.08257215260399 0.064337950664334 miRanda -0.283494673607 0.00272278244160319 NA NA NA hsa-miR-324-3p RASGRP3 1.51345381556672 0.0038447546677657 -1.08257215260399 0.064337950664334 MirTarget -0.281089477903603 7.56138882880018e-06 NA NA NA hsa-miR-339-5p RASGRP3 1.23326828594484 0.0307501214818698 -1.08257215260399 0.064337950664334 miRanda -0.278438952103855 1.2756977319625e-06 NA NA NA hsa-miR-34c-5p RASGRP3 2.64675661251039 0.0157394735757952 -1.08257215260399 0.064337950664334 miRanda -0.111453300191915 0.000201513569045769 NA NA NA hsa-miR-590-5p RASGRP3 1.51400888103768 0.0023888567923017 -1.08257215260399 0.064337950664334 miRanda -0.259562538765816 8.86830479663219e-05 NA NA NA hsa-miR-1271-5p RPS6KA2 0.212382644103427 0.742544160267329 -2.65030014005572 0.000604235142902453 mirMAP -0.205729695165376 0.00268820251345792 NA NA NA hsa-miR-17-5p RPS6KA2 2.3269271449522 2.13987445663942e-05 -2.65030014005572 0.000604235142902453 TargetScan -0.277716691933536 0.000491109025542043 NA NA NA hsa-miR-193a-3p RPS6KA2 0.646392169474854 0.207134343676122 -2.65030014005572 0.000604235142902453 mirMAP -0.243071120724014 0.00506444605891364 NA NA NA hsa-miR-19b-3p RPS6KA2 1.67581705793313 0.000858910586302716 -2.65030014005572 0.000604235142902453 MirTarget -0.275239570627294 0.00167663626230614 NA NA NA hsa-miR-200c-3p RPS6KA2 6.47012025883743 2.64500707716408e-26 -2.65030014005572 0.000604235142902453 miRNATAP -0.185226101150327 0.005371700638205 NA NA NA hsa-miR-30e-5p RPS6KA2 0.780047227271616 0.0346714425913016 -2.65030014005572 0.000604235142902453 MirTarget -0.487113159267505 5.36366592420531e-05 NA NA NA hsa-miR-378a-3p RPS6KA2 1.46612141870273 0.0466660641196872 -2.65030014005572 0.000604235142902453 MirTarget -0.251494688876595 2.23223122446489e-05 NA NA NA hsa-miR-378c RPS6KA2 0.449601775771001 0.4993814483956 -2.65030014005572 0.000604235142902453 MirTarget -0.194068395078508 0.00355016245964441 NA NA NA hsa-miR-9-3p RPS6KA2 1.69328215716742 0.125170982657059 -2.65030014005572 0.000604235142902453 MirTarget -0.173109404251115 1.61584766530112e-05 NA NA NA hsa-miR-9-5p RPS6KA2 1.79620806707734 0.14526963042518 -2.65030014005572 0.000604235142902453 miRNATAP -0.179360056481064 3.30496459020001e-07 NA NA NA hsa-miR-130a-3p RPS6KA5 0.176861046122832 0.7577473016872 0.227262565675153 0.753510251838746 MirTarget -0.22674424368671 0.00155782350001791 NA NA NA hsa-miR-130a-5p RPS6KA5 1.58028512890005 0.024346333013728 0.227262565675153 0.753510251838746 mirMAP -0.165149616144186 0.00535732012858063 NA NA NA hsa-miR-148b-3p RPS6KA5 1.75622244535669 8.84414356040579e-08 0.227262565675153 0.753510251838746 MirTarget -0.415338093006742 0.000859856714904172 NA NA NA hsa-miR-17-5p RPS6KA5 2.3269271449522 2.13987445663942e-05 0.227262565675153 0.753510251838746 MirTarget;TargetScan -0.19743672323001 0.00780551419377463 NA NA NA hsa-miR-18a-5p RPS6KA5 3.90770175770219 9.15298615034137e-10 0.227262565675153 0.753510251838746 MirTarget -0.18783456293557 0.00261979052365785 NA NA NA hsa-miR-20a-3p RPS6KA5 1.9920766549842 0.000624458530894697 0.227262565675153 0.753510251838746 miRNATAP -0.230600369788416 0.000959839928349043 NA NA NA hsa-miR-301a-3p RPS6KA5 1.99338115332667 0.000813358604963724 0.227262565675153 0.753510251838746 MirTarget -0.20907145018513 0.00223724688936221 NA NA NA hsa-miR-335-3p RPS6KA5 1.19503568251824 0.0938852560631551 0.227262565675153 0.753510251838746 mirMAP -0.228825485118145 5.96273254321325e-05 NA NA NA hsa-miR-664a-3p RPS6KA5 0.249882351950296 0.56171157318348 0.227262565675153 0.753510251838746 MirTarget;mirMAP -0.260715906414115 0.00681821788484464 NA NA NA hsa-miR-141-3p RPS6KA6 7.30474126597325 1.45115996357606e-24 -4.01589146007697 0.00361422176832556 MirTarget -0.30702156340192 0.00250736247952691 NA NA NA hsa-miR-15b-5p RPS6KA6 3.32329949959268 8.40210501034588e-13 -4.01589146007697 0.00361422176832556 MirTarget -0.630779583352634 0.000112057448754317 NA NA NA hsa-miR-16-5p RPS6KA6 2.93575808220754 2.15436817162977e-10 -4.01589146007697 0.00361422176832556 MirTarget -0.757078300034172 4.28813440897308e-06 NA NA NA hsa-miR-17-5p RPS6KA6 2.3269271449522 2.13987445663942e-05 -4.01589146007697 0.00361422176832556 TargetScan -0.429125605520815 0.00257843057134291 NA NA NA hsa-miR-19b-3p RPS6KA6 1.67581705793313 0.000858910586302716 -4.01589146007697 0.00361422176832556 MirTarget -0.408003865579579 0.00914510270200835 NA NA NA hsa-miR-20a-3p RPS6KA6 1.9920766549842 0.000624458530894697 -4.01589146007697 0.00361422176832556 MirTarget -0.367180983126307 0.00636307573029767 NA NA NA hsa-miR-34a-5p RRAS 0.830377770217786 0.0477544831885907 -1.9126057841147 0.000230923222509551 miRNAWalker2_validate;MirTarget;miRNATAP -0.19354174319933 0.00681707579549125 NA NA NA hsa-miR-106a-5p RRAS2 3.98693608217557 9.37722470816656e-07 -0.654043591163765 0.378952792152607 miRNATAP -0.194014066974753 0.000122962254979393 NA NA NA hsa-miR-194-5p RRAS2 0.691219038144468 0.523143086635506 -0.654043591163765 0.378952792152607 MirTarget -0.110427631466685 0.00442051662843801 NA NA NA hsa-miR-30b-5p SOS1 0.0238659735605804 0.953223658270319 -0.317916313975443 0.241700272513698 mirMAP -0.108560527488227 0.00434235766945579 NA NA NA hsa-miR-339-5p SOS1 1.23326828594484 0.0307501214818698 -0.317916313975443 0.241700272513698 miRNATAP -0.123853061266441 2.87456784370318e-06 NA NA NA hsa-let-7a-3p SOS2 0.82512001802525 0.0468122405194487 -0.267591445900317 0.496928330255155 miRNATAP -0.164368847616136 0.00237247406832302 NA NA NA hsa-miR-193a-3p SOS2 0.646392169474854 0.207134343676122 -0.267591445900317 0.496928330255155 PITA;miRanda;miRNATAP -0.120918057682943 0.00561915694088728 NA NA NA hsa-miR-590-3p SOS2 2.35429565068338 2.79601879608564e-06 -0.267591445900317 0.496928330255155 miRanda;mirMAP -0.188531608844422 1.41164746076931e-05 NA NA NA hsa-miR-590-5p SOS2 1.51400888103768 0.0023888567923017 -0.267591445900317 0.496928330255155 PITA;miRanda;miRNATAP -0.17241746507823 0.000101790255421271 NA NA NA hsa-miR-148b-3p SRF 1.75622244535669 8.84414356040579e-08 -1.61859139334396 3.13150320883435e-07 mirMAP -0.198124803181328 0.0003371649957885 NA NA NA hsa-miR-1976 SRF 3.27217274919653 3.16337235854532e-12 -1.61859139334396 3.13150320883435e-07 mirMAP -0.145319903106526 0.000102204235087891 NA NA NA hsa-miR-200a-3p SRF 6.336081120041 4.024313571871e-16 -1.61859139334396 3.13150320883435e-07 miRTarBase -0.117259988380599 7.56339573760863e-08 NA NA NA hsa-miR-200b-3p SRF 5.56167217794639 6.43540045061709e-16 -1.61859139334396 3.13150320883435e-07 TargetScan -0.105304515824282 2.42067053148187e-05 NA NA NA hsa-miR-454-3p SRF 1.40269869979902 0.00366085847011367 -1.61859139334396 3.13150320883435e-07 mirMAP -0.125509331149505 0.000863157075566615 NA NA NA hsa-miR-140-5p STK3 -0.634610285725923 0.126670572966239 -0.130071437281501 0.665272694668143 PITA;miRanda -0.163815378245803 6.24798783355841e-05 NA NA NA hsa-miR-28-3p STK3 -0.992446114847535 0.0188188359018203 -0.130071437281501 0.665272694668143 MirTarget;PITA -0.122015424625475 0.0024872998460855 NA NA NA hsa-miR-29b-2-5p STK3 -0.596051745078872 0.189540844841389 -0.130071437281501 0.665272694668143 MirTarget -0.11593186403124 0.00200385372125216 NA NA NA hsa-miR-23b-3p STK4 -0.581135273821923 0.190478897170459 0.644532983269161 0.0384325095148309 MirTarget;miRNATAP -0.11595615144743 0.00373818307526686 NA NA NA hsa-miR-30b-5p STK4 0.0238659735605804 0.953223658270319 0.644532983269161 0.0384325095148309 mirMAP -0.158688282482927 0.000278673995592074 NA NA NA hsa-miR-223-3p STMN1 2.27436751816553 0.00779697425178179 1.82029230786843 6.5341043175874e-05 miRNAWalker2_validate;miRTarBase -0.122999088294078 4.43068102284186e-05 27577078;18555017;22470493 miR 223 increases gallbladder cancer cell sensitivity to docetaxel by downregulating STMN1; We determined that STMN1 was negatively correlated with and regulated by miR-223 in GBC miR-223 increased GBC sensitivity to docetaxel in vitro and in vivo and the induced sensitivity to docetaxel was suppressed by the restoration of STMN1 expression; These findings indicated that miR-223 might serve as an onco-suppressor that enhances susceptibility to docetaxel by downregulating STMN1 in GBC highlighting its promising therapeutic value;A strong inverse relationship between STMN1 mRNA and miR-223 expressions was shown P = .006; A substantial reduction in STMN1 protein was further demonstrated upon restoration of miR-223 expression in HCC cell lines; We further showed that miR-223 readily could suppress the luciferase activity in reporter construct containing the STMN1 3' untranslated region P = .02;We also explored the regulation of STMN1 expression by microRNA-223; We finally confirmed that STMN1 is a putative downstream target of miR-223 in gastric cancer ;; bladder cancer;liver cancer;gastric cancer hsa-miR-338-3p STMN1 0.447551118940466 0.558485097370031 1.82029230786843 6.5341043175874e-05 miRanda -0.135667977705533 6.26623520830491e-05 NA NA NA hsa-let-7a-3p TAOK1 0.82512001802525 0.0468122405194487 0.790322229494077 0.29616796227696 MirTarget;miRNATAP -0.350587462781213 0.000756392177702044 NA NA NA hsa-let-7d-5p TAOK1 0.831142050231414 0.0126955498524287 0.790322229494077 0.29616796227696 miRNATAP -0.428852429910392 0.00103544774184506 NA NA NA hsa-miR-222-3p TAOK1 1.54730827524553 0.0223014220569407 0.790322229494077 0.29616796227696 miRNATAP -0.169901466053845 0.00718741844617687 NA NA NA hsa-miR-26a-5p TAOK1 -0.352368463397074 0.362040749917446 0.790322229494077 0.29616796227696 mirMAP;miRNATAP -0.313363088073576 0.00542569188540844 NA NA NA hsa-miR-29a-5p TAOK1 0.0748295222568571 0.884125894063293 0.790322229494077 0.29616796227696 mirMAP -0.287948621114005 0.000592809669240074 NA NA NA hsa-miR-30b-5p TAOK1 0.0238659735605804 0.953223658270319 0.790322229494077 0.29616796227696 miRNAWalker2_validate;MirTarget -0.36634329504645 0.00058703285515273 NA NA NA hsa-miR-30e-5p TAOK1 0.780047227271616 0.0346714425913016 0.790322229494077 0.29616796227696 MirTarget -0.361746289345547 0.0021150799666311 NA NA NA hsa-miR-320a TAOK1 -0.912036444869976 0.0565555443926988 0.790322229494077 0.29616796227696 mirMAP;miRNATAP -0.239190107130336 0.00803185489520396 NA NA NA hsa-miR-339-5p TAOK1 1.23326828594484 0.0307501214818698 0.790322229494077 0.29616796227696 miRanda -0.270029754301723 0.000309691334823722 NA NA NA hsa-miR-342-3p TAOK1 1.31107714473009 0.0207211910724662 0.790322229494077 0.29616796227696 miRanda -0.203434041274251 0.00721791135147957 NA NA NA hsa-miR-590-3p TAOK1 2.35429565068338 2.79601879608564e-06 0.790322229494077 0.29616796227696 miRanda;mirMAP -0.266135260580751 0.00159605253569902 NA NA NA hsa-miR-664a-3p TAOK1 0.249882351950296 0.56171157318348 0.790322229494077 0.29616796227696 mirMAP -0.277760270581751 0.00585763504126356 NA NA NA hsa-miR-28-3p TAOK2 -0.992446114847535 0.0188188359018203 -0.231284781521008 0.334053150690341 PITA -0.102792483044994 0.00130290122386194 NA NA NA hsa-miR-106a-5p TAOK3 3.98693608217557 9.37722470816656e-07 0.114043662398584 0.775639161459909 MirTarget -0.162740368513481 9.56790897354226e-10 NA NA NA hsa-miR-106b-5p TAOK3 2.80565545918114 1.14547999022566e-09 0.114043662398584 0.775639161459909 MirTarget -0.172769690590989 0.000303902543696555 NA NA NA hsa-miR-195-3p TAOK3 -2.39100534119332 0.000185405399054065 0.114043662398584 0.775639161459909 MirTarget -0.103770134852538 0.00321336180341814 NA NA NA hsa-miR-200b-3p TAOK3 5.56167217794639 6.43540045061709e-16 0.114043662398584 0.775639161459909 MirTarget;TargetScan -0.125124985839417 5.41879477615287e-05 NA NA NA hsa-miR-20b-5p TAOK3 4.5662923200279 4.75238200639144e-05 0.114043662398584 0.775639161459909 MirTarget -0.118125078598461 1.01352997001168e-09 NA NA NA hsa-miR-218-5p TAOK3 -1.62589026509455 0.0400573414088521 0.114043662398584 0.775639161459909 miRNATAP -0.137568242011929 9.44603846969865e-07 NA NA NA hsa-miR-33a-3p TAOK3 2.06269680799532 0.00156436055383943 0.114043662398584 0.775639161459909 miRNATAP -0.10259326268304 0.00300755231858152 NA NA NA hsa-miR-361-5p TAOK3 0.00649167180664723 0.985202350239079 0.114043662398584 0.775639161459909 miRanda -0.274412314727711 2.73417558366351e-05 NA NA NA hsa-miR-429 TAOK3 6.39965293994036 1.96920201593608e-18 0.114043662398584 0.775639161459909 MirTarget;PITA;miRanda;miRNATAP -0.128139166746448 8.86560653235701e-06 NA NA NA hsa-miR-592 TAOK3 2.80403350008555 0.0293520213681333 0.114043662398584 0.775639161459909 miRNATAP -0.111792280863055 1.20912992039952e-07 NA NA NA hsa-miR-93-5p TAOK3 2.65964181833033 2.58315947526774e-08 0.114043662398584 0.775639161459909 MirTarget -0.219221539713454 1.84951766584972e-06 NA NA NA hsa-miR-141-3p TGFB2 7.30474126597325 1.45115996357606e-24 -1.43663821995393 0.208151431685717 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.215624739416799 0.00999464963415708 NA NA NA hsa-miR-142-3p TGFB2 4.35304505457969 3.10014573651358e-10 -1.43663821995393 0.208151431685717 miRNATAP -0.239982637825598 0.00829657759355293 NA NA NA hsa-miR-148b-3p TGFB2 1.75622244535669 8.84414356040579e-08 -1.43663821995393 0.208151431685717 MirTarget -0.652112155639784 0.000929853930431754 NA NA NA hsa-miR-200a-3p TGFB2 6.336081120041 4.024313571871e-16 -1.43663821995393 0.208151431685717 MirTarget;miRNATAP -0.351128170275698 7.00885632360109e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 6.35084246337388 7.89944323347948e-08 -1.43663821995393 0.208151431685717 MirTarget -0.267521839692763 3.62940840958117e-07 NA NA NA hsa-miR-2277-5p TGFB2 3.02139935290539 0.0134629626930938 -1.43663821995393 0.208151431685717 MirTarget -0.249573719882911 0.00777879243940924 NA NA NA hsa-miR-362-5p TGFB2 -1.22309034685697 0.0452665543907975 -1.43663821995393 0.208151431685717 MirTarget -0.314690950040788 0.00297612558507577 NA NA NA hsa-miR-375 TGFB2 3.3784490463318 0.0449946294355695 -1.43663821995393 0.208151431685717 miRNAWalker2_validate -0.113027113272895 0.00302877404950613 NA NA NA hsa-miR-429 TGFB2 6.39965293994036 1.96920201593608e-18 -1.43663821995393 0.208151431685717 miRNATAP -0.317868138018968 0.000128726503171991 NA NA NA hsa-miR-500a-5p TGFB2 0.0170829425378565 0.973960207660626 -1.43663821995393 0.208151431685717 mirMAP -0.329451267369997 0.00832586461531593 NA NA NA hsa-miR-500b-5p TGFB2 0.0167434146432646 0.974498641907253 -1.43663821995393 0.208151431685717 MirTarget -0.327405186316064 0.00868447231417683 NA NA NA hsa-let-7f-1-3p TGFB3 1.61507869803314 0.00069342464777815 -2.17732916051247 0.00128816902304754 MirTarget -0.28544584743246 0.000437940636180159 NA NA NA hsa-miR-151a-5p TGFB3 1.0755926560327 0.00684662665520532 -2.17732916051247 0.00128816902304754 MirTarget -0.500615620870658 2.12682352848945e-07 NA NA NA hsa-miR-629-3p TGFB3 3.48282157979573 4.9176538695908e-08 -2.17732916051247 0.00128816902304754 MirTarget -0.241806561248301 3.8838732840276e-05 NA NA NA hsa-let-7b-5p TGFBR1 -0.189422992330471 0.651878220048983 -0.505713612135208 0.324744061078335 miRNATAP -0.242601587479934 0.000517890990887836 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC; In luciferase assays the risk-associated allele for rs868 was associated with half the luciferase expression in the presence of miRNA let-7b-5p compared with protective allele suggesting more binding of let-7b-5p and less TGFBR1 expression colorectal cancer hsa-let-7c-5p TGFBR1 -2.03831836681378 0.0228401148731997 -0.505713612135208 0.324744061078335 miRNAWalker2_validate;miRTarBase -0.141642653096274 9.4282969596595e-06 NA NA NA hsa-let-7g-5p TGFBR1 0.857251702023746 0.00647597344297273 -0.505713612135208 0.324744061078335 miRNATAP -0.267873123242374 0.00450205280436413 NA NA NA hsa-miR-101-3p TGFBR1 -1.12421603598195 0.0200907284788457 -0.505713612135208 0.324744061078335 miRNAWalker2_validate;miRNATAP -0.25766117737473 1.65614003073399e-05 NA NA NA hsa-miR-101-5p TGFBR1 -1.41522721523565 0.0166784131265028 -0.505713612135208 0.324744061078335 mirMAP -0.147066901987004 0.00277627040116552 NA NA NA hsa-miR-128-3p TGFBR1 1.36248409467631 0.00408435995818078 -0.505713612135208 0.324744061078335 miRNAWalker2_validate;miRTarBase -0.218506283449698 0.000352839376558225 NA NA NA hsa-miR-200b-3p TGFBR1 5.56167217794639 6.43540045061709e-16 -0.505713612135208 0.324744061078335 mirMAP -0.254716587127543 6.86106889972148e-11 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-3065-5p TGFBR1 2.14185373842821 0.0609400502269891 -0.505713612135208 0.324744061078335 mirMAP -0.111612566907259 0.000387470900601915 NA NA NA hsa-miR-361-5p TGFBR1 0.00649167180664723 0.985202350239079 -0.505713612135208 0.324744061078335 miRanda;mirMAP;miRNATAP -0.236124496506177 0.00538272648027843 NA NA NA hsa-miR-374a-5p TGFBR1 0.278549982012055 0.45888283715888 -0.505713612135208 0.324744061078335 mirMAP -0.235099661936825 0.0027662227971746 NA NA NA hsa-miR-429 TGFBR1 6.39965293994036 1.96920201593608e-18 -0.505713612135208 0.324744061078335 miRanda;miRNATAP -0.219958031472476 1.89353165194703e-09 NA NA NA hsa-miR-452-5p TGFBR1 2.45466810475361 0.00114794259949532 -0.505713612135208 0.324744061078335 mirMAP -0.12029641667783 0.00160222545222133 NA NA NA hsa-miR-106a-5p TGFBR2 3.98693608217557 9.37722470816656e-07 -2.73335386207413 1.90521047769449e-05 miRTarBase;miRNATAP -0.150075579446973 0.000678032994747311 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 2.80565545918114 1.14547999022566e-09 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.322471465860215 3.16067025691578e-05 NA NA NA hsa-miR-130b-3p TGFBR2 3.9204771543282 1.2714917955808e-11 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRNATAP -0.213593769351299 0.000481445052465677 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 2.3269271449522 2.13987445663942e-05 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.215187086531778 0.00117456700436254 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-19b-3p TGFBR2 1.67581705793313 0.000858910586302716 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRNATAP -0.234916804375819 0.0012466880966742 NA NA NA hsa-miR-20a-5p TGFBR2 2.13553469875764 0.000181201072324354 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.20359230487236 0.00142468050698815 NA NA NA hsa-miR-23a-3p TGFBR2 0.925125296618358 0.0127293543936914 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.3112107869471 0.00186820770972094 NA NA NA hsa-miR-23b-3p TGFBR2 -0.581135273821923 0.190478897170459 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.396202249615838 1.57688737786639e-06 NA NA NA hsa-miR-33a-3p TGFBR2 2.06269680799532 0.00156436055383943 -2.73335386207413 1.90521047769449e-05 mirMAP -0.339046189283903 6.57537246748805e-10 NA NA NA hsa-miR-429 TGFBR2 6.39965293994036 1.96920201593608e-18 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.154633278802292 0.00105886610005129 NA NA NA hsa-miR-502-5p TGFBR2 -0.614788359240004 0.318237800399635 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.208965899672639 0.000640450504063216 NA NA NA hsa-miR-590-3p TGFBR2 2.35429565068338 2.79601879608564e-06 -2.73335386207413 1.90521047769449e-05 miRanda -0.257641439028576 0.000348477751441795 NA NA NA hsa-miR-590-5p TGFBR2 1.51400888103768 0.0023888567923017 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.215019200724794 0.00350246324243056 NA NA NA hsa-miR-9-3p TGFBR2 1.69328215716742 0.125170982657059 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.160602299630754 1.35393247444156e-06 NA NA NA hsa-miR-9-5p TGFBR2 1.79620806707734 0.14526963042518 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.159363587250353 4.39117866793099e-08 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 1.87892405805529 1.27013821556583e-05 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate -0.35871093164404 2.09836401920038e-05 NA NA NA hsa-miR-93-5p TGFBR2 2.65964181833033 2.58315947526774e-08 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRNATAP -0.331832507260209 9.43453774065979e-06 NA NA NA hsa-miR-361-5p TNF 0.00649167180664723 0.985202350239079 2.70587865709665 0.00827809785812044 miRanda -0.699393715835311 3.55980064084335e-05 NA NA NA hsa-miR-654-3p TNF -1.00320329950348 0.243908885746048 2.70587865709665 0.00827809785812044 miRNATAP -0.184952039903252 0.006307888857058 NA NA NA hsa-miR-766-3p TNFRSF1A 2.6460519504539 8.60200045402435e-06 -0.659377512671059 0.0889418349306143 MirTarget -0.100128221820332 0.00599976091689645 NA NA NA hsa-miR-29a-5p TRAF6 0.0748295222568571 0.884125894063293 -0.433986140670238 0.255703111868558 MirTarget;mirMAP -0.131349460411584 0.00187386742085026 NA NA NA hsa-miR-335-3p TRAF6 1.19503568251824 0.0938852560631551 -0.433986140670238 0.255703111868558 MirTarget -0.103633187493345 0.000576193925904453 NA NA NA hsa-miR-374b-5p TRAF6 -0.114749866169918 0.764888930049438 -0.433986140670238 0.255703111868558 mirMAP -0.178980277400146 0.0017125695274895 NA NA NA hsa-miR-497-5p TRAF6 -1.44150596209372 0.0225146607606395 -0.433986140670238 0.255703111868558 MirTarget -0.112318911916622 0.000957235438651535 NA NA NA