miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-155-5p ABI2 0.708423342476697 0.00686702252429413 0.175334214271024 0.14786862779391 mirMAP -0.230411903308805 1.83016869955862e-18 NA NA NA hsa-miR-155-5p ABL2 0.708423342476697 0.00686702252429413 0.820053510414726 8.89463322803119e-15 mirMAP -0.114412981698957 7.14224141151095e-06 NA NA NA hsa-miR-155-5p ACADSB 0.708423342476697 0.00686702252429413 -0.980386878006724 4.71401937792336e-11 mirMAP -0.133444882437795 0.000182625531496312 NA NA NA hsa-miR-155-5p ACTA1 0.708423342476697 0.00686702252429413 -0.343746496261035 0.368798210286962 MirTarget;miRNATAP -0.450957165331554 2.29062727865474e-07 NA NA NA hsa-miR-155-5p ACVR2A 0.708423342476697 0.00686702252429413 -0.409014715537696 0.000390733013426116 miRNATAP -0.149224110497071 1.42227709786741e-08 NA NA NA hsa-miR-155-5p ADH5 0.708423342476697 0.00686702252429413 -0.368960300330071 0.000134691028852477 miRNAWalker2_validate -0.101715842289166 4.97237332348049e-06 NA NA NA hsa-miR-155-5p AGL 0.708423342476697 0.00686702252429413 -0.172875378782425 0.166177828108359 miRNAWalker2_validate -0.128047287886447 7.24859589907617e-06 NA NA NA hsa-miR-155-5p AGTR1 0.708423342476697 0.00686702252429413 -2.46934800110457 1.19820706767538e-06 miRNAWalker2_validate;miRTarBase -0.762557088599767 6.29070023328908e-11 22525818 MicroRNA-155 miR-155 is one of the micro RNAs miRNA most consistently involved in neoplastic diseases and it is known to repress the angiotensin II type 1 receptor AGTR1; The aim of the present study was to evaluate the expressions of miR-155 and AGTR1 and to clarify the potential efficacy of anti-miR-155 alone and in combination with AGTR1 blocker losartan in endometrial cancers; Expressions of miR-155 and AGTR1 were evaluated using real-time PCR and immunohistochemistry; miR-155 was over-expressed and AGTR1 was underexpressed in endometrial carcinoma tissues; We checked that abolishing the function of miR-155 and AGTR1 by anti-miR-155 or losartan inhibited cell survival of endometrial carcinoma cells respectively and furthermore combined treatment showed synergistic effects; In this study we characterized the expressions of miR-155 and AGTR1 in endometrial tissues; The combined treatment with anti-miR-155 and losartan has a synergistic antiproliferative effect and an improved understanding is required to clarify whether miR-155 and AGTR1 can be used as a novel therapeutic target in endometrial cancer poor survival endometrial cancer hsa-miR-155-5p ALDH1A2 0.708423342476697 0.00686702252429413 -2.41097656885073 2.02467240298704e-08 miRNAWalker2_validate -0.474376859471066 2.79817102120485e-06 NA NA NA hsa-miR-155-5p AMIGO2 0.708423342476697 0.00686702252429413 0.610030607253541 0.0190294565433556 miRNAWalker2_validate -0.19859114225468 0.00101139515749859 NA NA NA hsa-miR-155-5p ANAPC16 0.708423342476697 0.00686702252429413 -0.562573593594966 5.30708721594642e-08 miRNAWalker2_validate -0.120234813529841 6.11298141121327e-07 NA NA NA hsa-miR-155-5p ANKH 0.708423342476697 0.00686702252429413 0.456470516243756 0.00391653561701281 mirMAP -0.163810408367196 6.99784042159404e-06 NA NA NA hsa-miR-155-5p ANO5 0.708423342476697 0.00686702252429413 -2.17078328848367 8.0164866381684e-07 MirTarget -0.6425090403256 2.17021384252011e-10 NA NA NA hsa-miR-155-5p ANTXR1 0.708423342476697 0.00686702252429413 0.824541697719349 0.00013866646046424 miRNAWalker2_validate -0.235348467452862 2.65658129915506e-06 NA NA NA hsa-miR-155-5p ANTXR2 0.708423342476697 0.00686702252429413 -0.725355669636325 0.00186407729445627 MirTarget;miRNATAP -0.328676471338119 5.38080666602038e-10 NA NA NA hsa-miR-155-5p AR 0.708423342476697 0.00686702252429413 -1.55428586679464 3.79681953414866e-06 mirMAP -0.561643111205876 1.61308470235173e-13 NA NA NA hsa-miR-155-5p ARHGAP5 0.708423342476697 0.00686702252429413 -0.123874599542773 0.263036005478456 mirMAP -0.182525194705949 7.90747106517052e-14 NA NA NA hsa-miR-155-5p ARL10 0.708423342476697 0.00686702252429413 -0.28129009619869 0.198316212901093 miRNAWalker2_validate -0.309000493858723 3.47682282066702e-10 NA NA NA hsa-miR-155-5p ARL8B 0.708423342476697 0.00686702252429413 -0.208090655274296 0.0111650980017705 miRNAWalker2_validate -0.108528720810332 4.1444882250435e-09 NA NA NA hsa-miR-155-5p ARMC2 0.708423342476697 0.00686702252429413 0.213717699654495 0.0931742301314418 miRNAWalker2_validate -0.143001040334946 8.29626745448726e-07 NA NA NA hsa-miR-155-5p ATF7 0.708423342476697 0.00686702252429413 0.0674049536109402 0.438061225007579 mirMAP -0.150210871777399 2.52625227605586e-15 NA NA NA hsa-miR-155-5p ATL2 0.708423342476697 0.00686702252429413 -0.383786242998031 0.000575339633888933 miRNAWalker2_validate -0.212645889476998 2.93365550806306e-18 NA NA NA hsa-miR-155-5p ATRNL1 0.708423342476697 0.00686702252429413 -1.68925010520238 1.18504412004834e-05 MirTarget;mirMAP -0.56509891569544 1.50539436738425e-10 NA NA NA hsa-miR-155-5p AXL 0.708423342476697 0.00686702252429413 -0.192387120808621 0.351100682892 miRNAWalker2_validate -0.162549868218671 0.000644011789552867 NA NA NA hsa-miR-155-5p BCL6 0.708423342476697 0.00686702252429413 -0.211315139145206 0.194893611053015 miRNAWalker2_validate;miRTarBase -0.187536472523021 4.43591697301522e-07 23169640 We show that Bcl6 is indirectly regulated by miR-155 through Mxd1/Mad1 up-regulation; Interestingly we found that miR-155 directly targets HDAC4 a corepressor partner of BCL6; Meta-analysis of the diffuse large B-cell lymphoma patient microarray data showed that miR-155 expression is inversely correlated with Bcl6 and Hdac4; Hence this study provides a better understanding of how miR-155 causes disruption of the BCL6 transcriptional machinery that leads to up-regulation of the survival and proliferation genes in miR-155-induced leukemias poor survival B cell lymphoma hsa-miR-155-5p BCORL1 0.708423342476697 0.00686702252429413 0.353628857162529 0.0121444298982527 MirTarget -0.179662576563314 2.09357090625628e-08 NA NA NA hsa-miR-155-5p BNC2 0.708423342476697 0.00686702252429413 -0.491277997679328 0.0998827438687705 MirTarget -0.384980937393975 1.3542870785987e-08 NA NA NA hsa-miR-155-5p BNIP2 0.708423342476697 0.00686702252429413 -0.0504396416676869 0.639071096410223 mirMAP -0.159966886462178 2.41500329751273e-11 NA NA NA hsa-miR-155-5p BOC 0.708423342476697 0.00686702252429413 -0.912042259856259 0.00560150824376481 MirTarget -0.443991432854015 3.08537801224943e-09 NA NA NA hsa-miR-155-5p BRWD1 0.708423342476697 0.00686702252429413 0.0451696387992726 0.659801155532707 mirMAP -0.146129749981849 1.83345186357314e-10 NA NA NA hsa-miR-155-5p C3orf18 0.708423342476697 0.00686702252429413 -1.27306229138932 4.26281069984149e-12 miRNATAP -0.281052009564078 6.62387520399607e-11 NA NA NA hsa-miR-155-5p CA5B 0.708423342476697 0.00686702252429413 -0.0659463723940039 0.65343650265455 mirMAP -0.213751106909065 7.95025161665999e-11 NA NA NA hsa-miR-155-5p CAB39L 0.708423342476697 0.00686702252429413 -1.76562312798893 2.94345232906232e-14 miRNAWalker2_validate -0.547508573867874 2.48004967007294e-26 NA NA NA hsa-miR-155-5p CACNA2D1 0.708423342476697 0.00686702252429413 -0.846445244760543 0.00675290229856498 mirMAP -0.452625027749042 1.51920144979058e-10 NA NA NA hsa-miR-155-5p CACNB4 0.708423342476697 0.00686702252429413 -1.05630266128413 0.000199554767655941 mirMAP;miRNATAP -0.284954117221075 1.57204775147539e-05 NA NA NA hsa-miR-155-5p CADM2 0.708423342476697 0.00686702252429413 -3.78218788728738 1.41764228771757e-12 mirMAP -0.813946101068262 9.2906492875038e-11 NA NA NA hsa-miR-155-5p CALU 0.708423342476697 0.00686702252429413 0.67344582166522 5.97080259757143e-10 miRNAWalker2_validate -0.103639088375621 5.87100932329319e-05 NA NA NA hsa-miR-155-5p CAMTA1 0.708423342476697 0.00686702252429413 -0.435942829625533 1.07285052615973e-05 miRNAWalker2_validate;MirTarget -0.113118233718981 7.50513642602021e-07 NA NA NA hsa-miR-155-5p CBR4 0.708423342476697 0.00686702252429413 -0.321356447145465 0.00664140114952099 miRNAWalker2_validate -0.163609788977303 9.65924868160158e-10 NA NA NA hsa-miR-155-5p CBX5 0.708423342476697 0.00686702252429413 0.164944902002406 0.244455396933291 mirMAP -0.148304347526243 4.6667314405582e-06 NA NA NA hsa-miR-155-5p CCDC82 0.708423342476697 0.00686702252429413 0.340994896735881 0.00084212597212377 miRNAWalker2_validate -0.121236706968728 2.08191803426822e-07 NA NA NA hsa-miR-155-5p CD109 0.708423342476697 0.00686702252429413 0.258681502538528 0.31950123858526 miRNAWalker2_validate -0.375167696796703 1.32240239717799e-10 NA NA NA hsa-miR-155-5p CDH13 0.708423342476697 0.00686702252429413 0.633821140250029 0.000935743050036489 miRNAWalker2_validate -0.218994384049734 6.79343018223557e-07 NA NA NA hsa-miR-155-5p CDH2 0.708423342476697 0.00686702252429413 -0.676171143790671 0.0404221186379083 miRNAWalker2_validate -0.303256163815609 6.88456765937673e-05 NA NA NA hsa-miR-155-5p CDH6 0.708423342476697 0.00686702252429413 0.844237970312101 3.39711224306149e-06 miRNAWalker2_validate -0.21177827056883 5.29365371717942e-07 NA NA NA hsa-miR-155-5p CELF2 0.708423342476697 0.00686702252429413 -1.10167045974223 7.93604111646927e-06 miRNATAP -0.116207685886131 0.0467064788662276 NA NA NA hsa-miR-155-5p CEP68 0.708423342476697 0.00686702252429413 -0.357161821208274 0.00245788466122221 MirTarget -0.224637094463584 2.82720182574432e-18 NA NA NA hsa-miR-155-5p CFL2 0.708423342476697 0.00686702252429413 -1.29748949709607 2.10137209702745e-06 miRNAWalker2_validate -0.506635743994224 1.21472093043643e-16 NA NA NA hsa-miR-155-5p CHD9 0.708423342476697 0.00686702252429413 -0.255057088271817 0.0209229203314752 miRNAWalker2_validate -0.130268852116807 2.19381309638583e-07 NA NA NA hsa-miR-155-5p CHST9 0.708423342476697 0.00686702252429413 -3.19932529158582 1.98123629158033e-07 miRNATAP -0.668323107787593 3.70268950840601e-06 NA NA NA hsa-miR-155-5p CLIC4 0.708423342476697 0.00686702252429413 -0.38961849989088 0.0412415922050508 miRNAWalker2_validate -0.330244980986186 5.07675322065124e-15 NA NA NA hsa-miR-155-5p CNTN3 0.708423342476697 0.00686702252429413 -2.45590160465804 9.49506353676956e-09 MirTarget -0.439175096243525 1.43935958493245e-05 NA NA NA hsa-miR-155-5p CNTN4 0.708423342476697 0.00686702252429413 -0.828286345837398 0.00133313844224883 miRNATAP -0.266815447912557 7.83627324160761e-06 NA NA NA hsa-miR-155-5p COL4A2 0.708423342476697 0.00686702252429413 1.02334447820144 1.14936313463397e-07 miRNAWalker2_validate -0.198213179651833 1.26181960726801e-05 NA NA NA hsa-miR-155-5p CPEB4 0.708423342476697 0.00686702252429413 -0.799852896258595 5.07681536757866e-11 mirMAP -0.168377416902814 3.61506822291519e-09 NA NA NA hsa-miR-155-5p CRAT 0.708423342476697 0.00686702252429413 -0.931030981909908 5.67059251856834e-06 miRNAWalker2_validate -0.1548591475666 0.00134943959393692 NA NA NA hsa-miR-155-5p CREBRF 0.708423342476697 0.00686702252429413 -0.366122742256368 0.00726639317725131 miRNAWalker2_validate;MirTarget;miRNATAP -0.192578091598253 4.08316785212934e-10 NA NA NA hsa-miR-155-5p CUL4B 0.708423342476697 0.00686702252429413 0.16169881183256 0.103573813832372 miRNAWalker2_validate -0.139440714332528 3.76457986841122e-10 NA NA NA hsa-miR-155-5p CUX1 0.708423342476697 0.00686702252429413 -0.0386238678767237 0.670496786532132 miRNAWalker2_validate -0.110265006510816 7.07834252082201e-08 NA NA NA hsa-miR-155-5p CYP2U1 0.708423342476697 0.00686702252429413 -0.698495804431182 0.000276910210145885 miRNAWalker2_validate -0.224930491850709 3.75058127776992e-07 NA NA NA hsa-miR-155-5p CYR61 0.708423342476697 0.00686702252429413 -0.314176738475582 0.226517098482191 miRNAWalker2_validate;miRTarBase -0.147513046967688 0.0145511482093852 NA NA NA hsa-miR-155-5p DACH2 0.708423342476697 0.00686702252429413 -1.63467942928075 0.000338069752315023 mirMAP -0.391047376771083 0.00023915417324434 NA NA NA hsa-miR-155-5p DBN1 0.708423342476697 0.00686702252429413 -0.230289496309915 0.227868943324431 miRNAWalker2_validate -0.223242616951281 2.86309190467305e-07 NA NA NA hsa-miR-155-5p DCAF10 0.708423342476697 0.00686702252429413 -0.0279033263526669 0.751078299753938 mirMAP -0.123165663305245 3.4553447357772e-10 NA NA NA hsa-miR-155-5p DCUN1D2 0.708423342476697 0.00686702252429413 0.173997349593849 0.122713441927886 miRNAWalker2_validate -0.180702464328504 4.85173098323937e-13 NA NA NA hsa-miR-155-5p DCUN1D4 0.708423342476697 0.00686702252429413 -0.256427886046376 0.0215922527238607 miRNATAP -0.190963521101808 9.08506429502037e-15 NA NA NA hsa-miR-155-5p DGKG 0.708423342476697 0.00686702252429413 -1.62731283052773 1.74564014186277e-07 mirMAP -0.463341781066276 1.05495717030943e-10 NA NA NA hsa-miR-155-5p DIXDC1 0.708423342476697 0.00686702252429413 -1.16493051519743 1.82036516809915e-06 MirTarget -0.47823557186072 9.9406174287258e-19 NA NA NA hsa-miR-155-5p DMD 0.708423342476697 0.00686702252429413 -1.50584693629303 4.05157194167937e-06 miRNAWalker2_validate -0.659524825307736 5.19997949354812e-20 NA NA NA hsa-miR-155-5p DOCK4 0.708423342476697 0.00686702252429413 0.502120813551762 0.00108492735386023 miRNAWalker2_validate -0.112833541827089 0.00163267098199179 NA NA NA hsa-miR-155-5p DPP8 0.708423342476697 0.00686702252429413 -0.0111980084702186 0.895366793793009 mirMAP -0.113958415179776 2.17654405968984e-09 NA NA NA hsa-miR-155-5p DYNC1I1 0.708423342476697 0.00686702252429413 -1.12027945318246 0.00107388621207106 MirTarget;miRNATAP -0.638645915311597 2.97967479648282e-17 NA NA NA hsa-miR-155-5p DYNC2H1 0.708423342476697 0.00686702252429413 -0.561256717164849 0.0173124924200168 miRNAWalker2_validate -0.39492739145306 5.18648788851599e-14 NA NA NA hsa-miR-155-5p EBF1 0.708423342476697 0.00686702252429413 -0.384145010395955 0.0885592077910048 miRNATAP -0.169000428593632 0.00121891328118044 NA NA NA hsa-miR-155-5p EBF2 0.708423342476697 0.00686702252429413 1.62736261668709 2.99671818165223e-06 mirMAP -0.461896897358309 9.58641487828911e-09 NA NA NA hsa-miR-155-5p EBF3 0.708423342476697 0.00686702252429413 -0.0578760368084503 0.814374219241758 mirMAP -0.233751497272482 3.6383366496513e-05 NA NA NA hsa-miR-155-5p EEF1A2 0.708423342476697 0.00686702252429413 -3.58448086492029 3.42501683188058e-10 miRNAWalker2_validate -0.474765059764583 0.000519179952425645 NA NA NA hsa-miR-155-5p EGFR 0.708423342476697 0.00686702252429413 -0.174568357475892 0.484508576205495 miRNAWalker2_validate;MirTarget -0.141357856151302 0.014760146223104 NA NA NA hsa-miR-155-5p EIF4E3 0.708423342476697 0.00686702252429413 -1.24277770218871 4.31281769728062e-12 mirMAP -0.199779807551201 3.13650838906491e-06 NA NA NA hsa-miR-155-5p ENTPD3 0.708423342476697 0.00686702252429413 -2.57455302613472 2.46343986336398e-11 MirTarget -0.475230725516847 2.07789402685135e-07 NA NA NA hsa-miR-155-5p EPHA5 0.708423342476697 0.00686702252429413 -0.957355977960908 0.0173317346329917 mirMAP -0.529962103030133 7.01922501864093e-09 NA NA NA hsa-miR-155-5p ERBB4 0.708423342476697 0.00686702252429413 -1.97496082958559 1.58728422015894e-05 mirMAP -0.439898076597004 3.95764753304022e-05 NA NA NA hsa-miR-155-5p ETNK2 0.708423342476697 0.00686702252429413 -0.693217362065208 0.0301324719371274 miRNATAP -0.48889573388904 9.69972803656457e-12 NA NA NA hsa-miR-155-5p ETV1 0.708423342476697 0.00686702252429413 -0.095537921341216 0.676735917831981 mirMAP -0.332545647943459 9.92763086605835e-11 NA NA NA hsa-miR-155-5p FADS1 0.708423342476697 0.00686702252429413 0.270403268873646 0.21340410024689 miRNAWalker2_validate -0.182320138033064 0.000276699544628645 NA NA NA hsa-miR-155-5p FAM114A1 0.708423342476697 0.00686702252429413 -0.460617237960932 9.94649104738941e-05 mirMAP -0.104744350466973 0.000141892647162855 NA NA NA hsa-miR-155-5p FAM168A 0.708423342476697 0.00686702252429413 -0.191804273695932 0.128925621940858 MirTarget -0.129024747604574 8.00417045176802e-06 NA NA NA hsa-miR-155-5p FAM20B 0.708423342476697 0.00686702252429413 0.0115906902718228 0.915994905003775 mirMAP -0.220510819240744 7.096377364447e-21 NA NA NA hsa-miR-155-5p FAM212B 0.708423342476697 0.00686702252429413 -0.999900600735786 4.86315864880706e-07 MirTarget;miRNATAP -0.340116179827747 4.05219080550451e-14 NA NA NA hsa-miR-155-5p FAM8A1 0.708423342476697 0.00686702252429413 -0.222229045123044 0.0265174303093394 mirMAP -0.156179856031187 2.47418027199708e-12 NA NA NA hsa-miR-155-5p FBXL2 0.708423342476697 0.00686702252429413 -0.0416322263648743 0.858599282744402 MirTarget -0.389914080395233 4.65150609787638e-14 NA NA NA hsa-miR-155-5p FGF2 0.708423342476697 0.00686702252429413 -1.0252152469847 2.26010255795334e-05 miRNAWalker2_validate;mirMAP -0.378938678037909 5.17046912532486e-12 NA NA NA hsa-miR-155-5p FGF5 0.708423342476697 0.00686702252429413 0.549344799655697 0.286593917342756 mirMAP -0.736546697435224 2.20926035002411e-10 NA NA NA hsa-miR-155-5p FGF7 0.708423342476697 0.00686702252429413 -0.41434019544902 0.185809734564159 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.32699153156563 5.28065147489088e-06 NA NA NA hsa-miR-155-5p FGF9 0.708423342476697 0.00686702252429413 -0.567473807130705 0.17094770957627 miRNATAP -0.323837112604256 0.000735733632731601 NA NA NA hsa-miR-155-5p FIGN 0.708423342476697 0.00686702252429413 -0.904389390868205 0.00585165623379918 mirMAP -0.279458367653176 0.000244701119578839 NA NA NA hsa-miR-155-5p FKBP14 0.708423342476697 0.00686702252429413 0.489541418961584 8.14050781118145e-05 mirMAP -0.171251144438035 1.49697891782021e-09 NA NA NA hsa-miR-155-5p FKBP5 0.708423342476697 0.00686702252429413 -0.942251915802888 6.84066806283422e-06 mirMAP -0.129915824219278 0.00863972289108783 NA NA NA hsa-miR-155-5p FLNA 0.708423342476697 0.00686702252429413 -0.771411398655463 0.0137692934141899 miRNAWalker2_validate -0.521788184300339 7.6294719918698e-14 NA NA NA hsa-miR-155-5p FLRT2 0.708423342476697 0.00686702252429413 -0.0494818009325133 0.866084263577093 mirMAP -0.218120903599331 0.00130195770485116 NA NA NA hsa-miR-155-5p FMO2 0.708423342476697 0.00686702252429413 -0.967919428681366 0.0198670822156548 mirMAP -0.205200911177533 0.0346735816264295 NA NA NA hsa-miR-155-5p FOXK1 0.708423342476697 0.00686702252429413 0.73210588275574 1.03641806849443e-07 miRNAWalker2_validate;miRNATAP -0.131169716354285 5.12618854670859e-05 NA NA NA hsa-miR-155-5p FOXO3 0.708423342476697 0.00686702252429413 -0.0400929851881102 0.720284180374582 miRNAWalker2_validate;miRTarBase -0.149037327726078 3.1897499000475e-09 27596294;25480585;20371610;26398931;22027557;27107135 MiR-155 targets 3´UTR region of multiple components of the pro-oncogenic signaling cascades including FOXO3a tumor suppressor and RUNX2 transcription factor regulating metastatic potential in BC;The effect of miRNA155 on FOXO3a expression was examined by Western blotting; FOXO3a was found to be a possible target of miRNA155 as suggested by Targetscan website;MicroRNA 155 regulates cell survival growth and chemosensitivity by targeting FOXO3a in breast cancer; In this study we demonstrate the critical role of miR-155 in regulation of cell survival and chemosensitivity through down-regulation of FOXO3a in breast cancer; Further we identified FOXO3a as a direct target of miR-155; Sustained overexpression of miR-155 resulted in repression of FOXO3a protein without changing mRNA levels and knockdown of miR-155 increases FOXO3a; Finally inverse correlation between miR-155 and FOXO3a levels were observed in a panel of breast cancer cell lines and tumors; In conclusion our study reveals a molecular link between miR-155 and FOXO3a and presents evidence that miR-155 is a critical therapeutic target in breast cancer;In contrast downregulation of miR-155-5p increased sensitivity to bufalin and upregulated the expression of FOXO3A;Here we show that hypoxic conditions induce miR-155 expression in lung cancer cells and trigger a corresponding decrease in a validated target FOXO3A;Our results further revealed that forkhead box O3a FoxO3a was a miR-155 target in the heart; And miR-155 directly repressed FoxO3a whose expression was mitigated in miR-155 agomir and mimic treatment in vivo and in vitro ;;poor survival;;; breast cancer;lymphoma;breast cancer;breast cancer;lung cancer;breast cancer hsa-miR-155-5p FSTL1 0.708423342476697 0.00686702252429413 0.589175839273943 0.00382207095964144 miRNAWalker2_validate -0.221796770721394 2.23654405712681e-06 NA NA NA hsa-miR-155-5p FUBP3 0.708423342476697 0.00686702252429413 0.16259647720745 0.0231749095860824 miRNAWalker2_validate -0.111749143294179 1.62981218208516e-12 NA NA NA hsa-miR-155-5p FZD3 0.708423342476697 0.00686702252429413 0.104222443014639 0.603162213805448 mirMAP -0.300016671253164 2.23070692926437e-11 NA NA NA hsa-miR-155-5p GABARAPL1 0.708423342476697 0.00686702252429413 -1.20328483426322 2.1183796887727e-11 miRNAWalker2_validate -0.189765226247637 9.60167220434101e-06 NA NA NA hsa-miR-155-5p GABRB2 0.708423342476697 0.00686702252429413 -1.84121195758661 0.000285346502585098 mirMAP -0.520319442287303 1.00371120198505e-05 NA NA NA hsa-miR-155-5p GAPVD1 0.708423342476697 0.00686702252429413 0.202527030191773 0.0287161679228322 miRNAWalker2_validate -0.107037580974728 3.5829188783663e-07 NA NA NA hsa-miR-155-5p GCFC2 0.708423342476697 0.00686702252429413 0.265558569224479 0.00820489366435704 miRNAWalker2_validate -0.122241921649124 8.62979053236891e-08 NA NA NA hsa-miR-155-5p GFRA1 0.708423342476697 0.00686702252429413 -3.06995033064001 6.5107128166333e-10 mirMAP -0.527044827790814 8.00822161298056e-06 NA NA NA hsa-miR-155-5p GNB4 0.708423342476697 0.00686702252429413 -0.0613484279829617 0.760832392301006 miRNAWalker2_validate -0.186902336298677 5.40076138224294e-05 NA NA NA hsa-miR-155-5p GPAM 0.708423342476697 0.00686702252429413 0.141794492741679 0.297316336494304 miRNAWalker2_validate -0.15691452572025 3.93312646033883e-07 NA NA NA hsa-miR-155-5p GPM6B 0.708423342476697 0.00686702252429413 -2.1566086132752 4.65701200932464e-14 miRNAWalker2_validate;MirTarget -0.574459665212076 1.84670460588413e-18 NA NA NA hsa-miR-155-5p GRIP1 0.708423342476697 0.00686702252429413 -0.818995365925745 0.00110036000308407 miRNATAP -0.351901566090524 7.04780613961654e-10 NA NA NA hsa-miR-155-5p GYG1 0.708423342476697 0.00686702252429413 -0.445505811108426 0.000513821054464544 MirTarget -0.184437244872047 2.1940995796051e-10 NA NA NA hsa-miR-155-5p HBP1 0.708423342476697 0.00686702252429413 -0.454367094530242 9.57166882993669e-09 miRNAWalker2_validate;MirTarget;miRNATAP -0.113731416104752 4.06111423988032e-10 25666090 miR 155 promotes the growth of osteosarcoma in a HBP1 dependent mechanism; HMG-box transcription factor 1 HBP1 a strong Wnt pathway suppressor was found to be a target of miR-155; Restoration of HBP1 abolished the effect of miR-155 on OS cells sarcoma hsa-miR-155-5p HECA 0.708423342476697 0.00686702252429413 -0.217272199817125 0.0346289690839968 MirTarget -0.132968609315983 1.05448002538681e-08 NA NA NA hsa-miR-155-5p HIVEP2 0.708423342476697 0.00686702252429413 -0.000288491818339232 0.998225122290243 miRNAWalker2_validate;miRTarBase;miRNATAP -0.155835578234814 1.13357331976001e-07 NA NA NA hsa-miR-155-5p HSDL1 0.708423342476697 0.00686702252429413 0.150221412913353 0.160557790465022 miRNAWalker2_validate -0.137761777137794 1.16920472192096e-08 NA NA NA hsa-miR-155-5p HSPA4L 0.708423342476697 0.00686702252429413 -0.099897034975418 0.743997596825237 miRNAWalker2_validate -0.15290570043438 0.0315382322841949 NA NA NA hsa-miR-155-5p HTRA1 0.708423342476697 0.00686702252429413 0.213481585828939 0.258670710418387 miRNAWalker2_validate -0.145893552930569 0.000832606294657125 NA NA NA hsa-miR-155-5p HUNK 0.708423342476697 0.00686702252429413 0.471101097211073 0.103931368358304 mirMAP -0.190473708395018 0.00464408115835906 NA NA NA hsa-miR-155-5p IGF1 0.708423342476697 0.00686702252429413 -0.204400009155359 0.589799367662809 mirMAP -0.283971155134428 0.00120141206335237 NA NA NA hsa-miR-155-5p IGF1R 0.708423342476697 0.00686702252429413 0.116961071763603 0.57112438908184 mirMAP -0.126900539411504 0.0080143150381593 NA NA NA hsa-miR-155-5p IL13RA1 0.708423342476697 0.00686702252429413 0.0191243204801186 0.869494231966019 miRNAWalker2_validate;miRTarBase -0.145869581413575 2.83853738700115e-08 NA NA NA hsa-miR-155-5p IL17RD 0.708423342476697 0.00686702252429413 -0.0188801323132464 0.948726066054448 mirMAP -0.634989641233692 2.07661101231778e-24 NA NA NA hsa-miR-155-5p IL6ST 0.708423342476697 0.00686702252429413 -0.401511913072166 0.00675820073922165 mirMAP -0.151230052601547 9.34156571150511e-06 NA NA NA hsa-miR-155-5p IMPAD1 0.708423342476697 0.00686702252429413 0.290630844719405 0.000797933037534526 miRNAWalker2_validate -0.119654635811941 9.73865226220938e-10 NA NA NA hsa-miR-155-5p INA 0.708423342476697 0.00686702252429413 -2.5143567811517 4.2805734586076e-11 miRNAWalker2_validate -0.502479304232868 2.40404495502982e-08 NA NA NA hsa-miR-155-5p INPP5F 0.708423342476697 0.00686702252429413 0.0457326310808011 0.7032738714146 miRNAWalker2_validate -0.195240233702504 1.87655861500218e-13 NA NA NA hsa-miR-155-5p IRF2BP2 0.708423342476697 0.00686702252429413 0.35136442987087 6.96654000668309e-05 MirTarget;miRNATAP -0.129768064652283 7.83785327213289e-11 NA NA NA hsa-miR-155-5p ITGB5 0.708423342476697 0.00686702252429413 0.356193384860324 0.00663584424218538 miRNAWalker2_validate -0.114690343686882 0.000155979601780455 NA NA NA hsa-miR-155-5p JUN 0.708423342476697 0.00686702252429413 -0.932062991848233 5.08561574713346e-09 miRNAWalker2_validate;miRTarBase -0.181329105442378 1.35586343503244e-06 23693020 In the present study we demonstrated for the first time that activation of RAGE by S100P regulates oncogenic microRNA-155 miR-155 expression through Activator Protein-1 AP-1 stimulation in colon cancer cells colon cancer hsa-miR-155-5p KANK2 0.708423342476697 0.00686702252429413 -0.932286924516263 1.5601005567271e-05 miRNAWalker2_validate -0.430782903945026 1.13496468105124e-19 NA NA NA hsa-miR-155-5p KANSL1 0.708423342476697 0.00686702252429413 0.253755350077018 0.00277103487823364 miRNATAP -0.100361062669391 1.95589894600969e-07 NA NA NA hsa-miR-155-5p KANSL1L 0.708423342476697 0.00686702252429413 0.255330802639067 0.0101817636754057 MirTarget -0.126178229790918 2.09790867728841e-08 NA NA NA hsa-miR-155-5p KCNA1 0.708423342476697 0.00686702252429413 -2.35612495285297 0.000428588551648961 mirMAP;miRNATAP -0.765171714883585 7.31999521279374e-07 NA NA NA hsa-miR-155-5p KCND3 0.708423342476697 0.00686702252429413 -1.25081349685282 8.58949377013892e-05 mirMAP -0.224134165697698 0.00273438081645543 NA NA NA hsa-miR-155-5p KDELC1 0.708423342476697 0.00686702252429413 0.951900307549484 1.03985999132567e-11 miRNAWalker2_validate -0.100425644424753 0.00291771810612202 NA NA NA hsa-miR-155-5p KDELC2 0.708423342476697 0.00686702252429413 0.216170389477556 0.0898833025888716 miRNAWalker2_validate -0.147728154270278 3.53812934286967e-07 NA NA NA hsa-miR-155-5p KDM3A 0.708423342476697 0.00686702252429413 0.131877481414247 0.227108564700866 miRNAWalker2_validate;miRTarBase;miRNATAP -0.132765830306703 7.74256085387775e-08 NA NA NA hsa-miR-155-5p KDM5B 0.708423342476697 0.00686702252429413 0.273473274347411 0.0149095699410658 MirTarget -0.137119527111216 7.92090613611555e-08 NA NA NA hsa-miR-155-5p KIAA0430 0.708423342476697 0.00686702252429413 -0.304584793472401 0.00340668402488961 miRNAWalker2_validate -0.109573665016427 4.37270590147308e-06 NA NA NA hsa-miR-155-5p KIAA1462 0.708423342476697 0.00686702252429413 0.552874008595252 0.00404720415721057 MirTarget -0.105787396781413 0.0186448783805634 NA NA NA hsa-miR-155-5p KIAA2022 0.708423342476697 0.00686702252429413 -2.80598433621504 1.14813298037395e-09 mirMAP -0.724577520965431 1.1340838015947e-11 NA NA NA hsa-miR-155-5p KLHL5 0.708423342476697 0.00686702252429413 -0.046422067507204 0.794627882369291 miRNAWalker2_validate -0.239416737400963 2.6162838334584e-09 NA NA NA hsa-miR-155-5p KPNA4 0.708423342476697 0.00686702252429413 0.138060971190837 0.137094124998354 miRNATAP -0.144360887944471 2.36780443035357e-12 NA NA NA hsa-miR-155-5p LCA5 0.708423342476697 0.00686702252429413 0.344794733894058 0.0481852760843641 MirTarget -0.266170950486966 9.82491823052537e-12 NA NA NA hsa-miR-155-5p LDOC1 0.708423342476697 0.00686702252429413 -1.54380254969915 8.85970678718901e-09 miRNAWalker2_validate;miRTarBase -0.303784610917557 1.55272120847092e-06 NA NA NA hsa-miR-155-5p LEPROT 0.708423342476697 0.00686702252429413 -0.315730025278079 0.000278682729289365 mirMAP -0.12463319142345 2.03728968134725e-10 NA NA NA hsa-miR-155-5p LIN7C 0.708423342476697 0.00686702252429413 0.24175305422481 0.0265810890372601 miRNAWalker2_validate -0.100466998025187 6.06071034699417e-05 NA NA NA hsa-miR-155-5p LONRF2 0.708423342476697 0.00686702252429413 -2.03899615797417 9.63293546267136e-06 mirMAP -0.867911260199371 2.59060599005504e-17 NA NA NA hsa-miR-155-5p LPL 0.708423342476697 0.00686702252429413 -0.336826116635722 0.222514052149516 miRNAWalker2_validate -0.229625380705496 0.000316086839475083 NA NA NA hsa-miR-155-5p LPP 0.708423342476697 0.00686702252429413 -0.458891651324375 0.0447471835132921 mirMAP;miRNATAP -0.475375708999168 3.66486199528721e-22 NA NA NA hsa-miR-155-5p LRP1B 0.708423342476697 0.00686702252429413 -2.16345659630435 6.96966627503369e-08 MirTarget;miRNATAP -0.620753806703472 1.74094633296748e-11 NA NA NA hsa-miR-155-5p LTN1 0.708423342476697 0.00686702252429413 -0.178394461370594 0.0883864684111063 miRNAWalker2_validate -0.129175021037571 4.989899899205e-08 NA NA NA hsa-miR-155-5p LUC7L3 0.708423342476697 0.00686702252429413 0.440319559812325 0.00194458781499046 miRNAWalker2_validate -0.100816852831845 0.00231604224450575 NA NA NA hsa-miR-155-5p LY6K 0.708423342476697 0.00686702252429413 -0.751949034893577 0.112009719813468 miRNAWalker2_validate -0.22444310972098 0.0419477274281126 NA NA NA hsa-miR-155-5p MAP4K3 0.708423342476697 0.00686702252429413 -0.165252579270693 0.125706336991069 MirTarget -0.188353997532548 1.77839700663931e-15 NA NA NA hsa-miR-155-5p MAVS 0.708423342476697 0.00686702252429413 0.203467277689581 0.0750698059971376 miRNAWalker2_validate -0.138979331251556 8.31103290911483e-08 NA NA NA hsa-miR-155-5p MBLAC2 0.708423342476697 0.00686702252429413 -0.15563984652953 0.212552216231619 miRNAWalker2_validate -0.105060800160763 0.000253247198228776 NA NA NA hsa-miR-155-5p MCAM 0.708423342476697 0.00686702252429413 -0.323857758583791 0.133834564119439 miRNAWalker2_validate -0.346419668864048 5.98730919840358e-13 NA NA NA hsa-miR-155-5p MECP2 0.708423342476697 0.00686702252429413 -0.152019401131295 0.153664300014582 miRNAWalker2_validate;miRTarBase;miRNATAP -0.178427416988839 3.00916147261029e-14 NA NA NA hsa-miR-155-5p MED12L 0.708423342476697 0.00686702252429413 -0.193902580891031 0.552988997113131 miRNATAP -0.302259100195008 5.80171729683522e-05 NA NA NA hsa-miR-155-5p MEF2A 0.708423342476697 0.00686702252429413 -0.299000743634786 0.0124150173611637 miRNAWalker2_validate -0.230147973858415 8.76592564091005e-19 NA NA NA hsa-miR-155-5p MEGF10 0.708423342476697 0.00686702252429413 -0.588656686146848 0.0848159063822668 MirTarget -0.358128593721171 4.94856866083242e-06 NA NA NA hsa-miR-155-5p MEIS1 0.708423342476697 0.00686702252429413 -1.0148748088312 5.58199831086994e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.434722125221449 1.37078216070218e-14 NA NA NA hsa-miR-155-5p MFAP3L 0.708423342476697 0.00686702252429413 0.770933863602886 0.010377932646622 mirMAP -0.377472736066098 3.87409477698733e-08 NA NA NA hsa-miR-155-5p MITF 0.708423342476697 0.00686702252429413 -0.768678066533393 0.000222708938697959 miRNAWalker2_validate;miRTarBase;MirTarget -0.213012458221532 1.03236832158743e-05 25853464 microRNA 155 induced by interleukin 1ß represses the expression of microphthalmia associated transcription factor MITF M in melanoma cells melanoma hsa-miR-155-5p MKLN1 0.708423342476697 0.00686702252429413 0.027124575667826 0.748708358507484 mirMAP -0.103795364468038 5.0435156365576e-08 NA NA NA hsa-miR-155-5p MMP16 0.708423342476697 0.00686702252429413 0.339181683389834 0.222873688272483 mirMAP -0.475646707561487 1.052667490869e-14 NA NA NA hsa-miR-155-5p MPP2 0.708423342476697 0.00686702252429413 -0.979304354602387 0.0006144308249289 miRNAWalker2_validate -0.484110263140893 3.78333040632338e-14 NA NA NA hsa-miR-155-5p MYBL1 0.708423342476697 0.00686702252429413 0.493754443604026 0.0215216223713438 miRNAWalker2_validate;miRNATAP -0.162916378434521 0.00108294085466864 NA NA NA hsa-miR-155-5p NCALD 0.708423342476697 0.00686702252429413 -0.877973466780329 0.000124467786873093 mirMAP -0.311614459674042 2.65291740866211e-09 NA NA NA hsa-miR-155-5p NCKAP1 0.708423342476697 0.00686702252429413 -0.204902930626572 0.035299373048088 miRNAWalker2_validate -0.185612147727451 1.378798802688e-18 NA NA NA hsa-miR-155-5p NES 0.708423342476697 0.00686702252429413 0.502576814274105 0.00983275859144883 miRNAWalker2_validate -0.170815709357952 0.000150506768231779 NA NA NA hsa-miR-155-5p NFAT5 0.708423342476697 0.00686702252429413 0.461239695424155 0.000656069696676909 mirMAP;miRNATAP -0.177372730636563 9.22614852468153e-09 NA NA NA hsa-miR-155-5p NFIA 0.708423342476697 0.00686702252429413 -0.546116799329663 0.00406390884761114 miRNATAP -0.353918779401798 2.44771650046158e-17 NA NA NA hsa-miR-155-5p NFIB 0.708423342476697 0.00686702252429413 0.0225947120786127 0.907947126450015 miRNATAP -0.140090401586481 0.00192000022189485 NA NA NA hsa-miR-155-5p NNT 0.708423342476697 0.00686702252429413 -0.333138146421544 0.0280725273454042 mirMAP -0.102511425589144 0.00359509369744473 NA NA NA hsa-miR-155-5p NOTCH2 0.708423342476697 0.00686702252429413 0.138226358603258 0.351625722215957 miRNAWalker2_validate -0.132109550756748 0.000106986917584149 NA NA NA hsa-miR-155-5p NOVA1 0.708423342476697 0.00686702252429413 -2.03955007528378 1.32480844598322e-07 miRNAWalker2_validate;miRNATAP -0.52692533454637 4.26314282293982e-09 NA NA NA hsa-miR-155-5p NR2F2 0.708423342476697 0.00686702252429413 -0.138727905922965 0.397897286244025 miRNATAP -0.167445580815342 8.23209553666624e-06 NA NA NA hsa-miR-155-5p NR3C1 0.708423342476697 0.00686702252429413 -0.898894495561724 5.37287634787075e-07 miRNAWalker2_validate -0.114208110293999 0.00722410392361897 NA NA NA hsa-miR-155-5p NRCAM 0.708423342476697 0.00686702252429413 0.965298915183287 0.00399364937495822 mirMAP -0.239266351268622 0.00221993635816297 NA NA NA hsa-miR-155-5p NTRK2 0.708423342476697 0.00686702252429413 -0.735609554829713 0.0649549334443704 mirMAP -0.594026747418366 3.37579436125982e-11 NA NA NA hsa-miR-155-5p NUCKS1 0.708423342476697 0.00686702252429413 0.325102076142334 0.00397222584600734 miRNAWalker2_validate -0.143774991257405 2.10500749139227e-08 NA NA NA hsa-miR-155-5p OBSCN 0.708423342476697 0.00686702252429413 -0.193535993209974 0.409726765528711 miRNAWalker2_validate -0.182710371245573 0.000753705378517333 NA NA NA hsa-miR-155-5p OGN 0.708423342476697 0.00686702252429413 -1.91781397932278 0.000338785010402909 miRNATAP -0.716400806127385 4.98866564746965e-09 NA NA NA hsa-miR-155-5p OLFML3 0.708423342476697 0.00686702252429413 -0.793884579917701 0.000773668087141731 miRNATAP -0.201901978577717 0.000240600013001988 NA NA NA hsa-miR-155-5p OPHN1 0.708423342476697 0.00686702252429413 -0.118115012079407 0.380867787572875 mirMAP -0.235168637906738 1.92009500787762e-15 NA NA NA hsa-miR-155-5p OSR1 0.708423342476697 0.00686702252429413 -0.914235079349368 0.011234198005583 miRNATAP -0.326748947827029 9.10423160676352e-05 NA NA NA hsa-miR-155-5p OTUD7B 0.708423342476697 0.00686702252429413 0.125414398965607 0.159181493421655 mirMAP -0.13395219420814 1.31608698293965e-11 NA NA NA hsa-miR-155-5p OXCT1 0.708423342476697 0.00686702252429413 -0.990285629499563 2.84856165515729e-05 miRNAWalker2_validate -0.157806890872025 0.00461272520490746 NA NA NA hsa-miR-155-5p PACSIN3 0.708423342476697 0.00686702252429413 -0.27334408792554 0.250309873234724 miRNAWalker2_validate -0.285514421493378 1.31805500683714e-07 NA NA NA hsa-miR-155-5p PALLD 0.708423342476697 0.00686702252429413 -0.733799109511982 0.0016821174230045 miRNAWalker2_validate -0.392222301845379 5.65239036067887e-14 NA NA NA hsa-miR-155-5p PAX6 0.708423342476697 0.00686702252429413 -0.444286149214719 0.0468893513390666 mirMAP -0.120779773843924 0.0204073602056867 NA NA NA hsa-miR-155-5p PBRM1 0.708423342476697 0.00686702252429413 -0.0289742605876446 0.786010644624529 miRNAWalker2_validate -0.150427066603614 2.94487677501897e-10 NA NA NA hsa-miR-155-5p PCDH9 0.708423342476697 0.00686702252429413 -1.82279707707595 3.76874897040946e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.588331643744222 7.26911408124346e-09 NA NA NA hsa-miR-155-5p PCMTD1 0.708423342476697 0.00686702252429413 -0.481814036975657 7.02844288535814e-05 mirMAP -0.217809837642979 5.77212905030336e-16 NA NA NA hsa-miR-155-5p PCYOX1 0.708423342476697 0.00686702252429413 -0.358488256924208 0.000634769673819883 miRNAWalker2_validate -0.231252557916455 3.59798416472939e-25 NA NA NA hsa-miR-155-5p PDE1A 0.708423342476697 0.00686702252429413 -1.11950661230575 3.02164435549881e-06 mirMAP -0.254530295179554 5.49259084328357e-06 NA NA NA hsa-miR-155-5p PDE3A 0.708423342476697 0.00686702252429413 -0.206426579279772 0.513859856563382 miRNAWalker2_validate -0.55418726787676 1.70562364353625e-15 NA NA NA hsa-miR-155-5p PDPR 0.708423342476697 0.00686702252429413 0.163813448707733 0.242671572026521 miRNAWalker2_validate -0.10658375250671 0.000984344926047757 NA NA NA hsa-miR-155-5p PEG3 0.708423342476697 0.00686702252429413 -1.74045975879828 2.73780805311935e-07 miRNATAP -0.588417903275365 1.69924277142036e-14 NA NA NA hsa-miR-155-5p PGAP1 0.708423342476697 0.00686702252429413 -0.179817176331677 0.346276670748295 mirMAP -0.264596054382672 7.56787717631117e-10 NA NA NA hsa-miR-155-5p PGR 0.708423342476697 0.00686702252429413 -1.70372832227161 1.59241316109545e-07 mirMAP -0.554693612089091 5.96870322015499e-14 20388420;19454029;23162645 It's indicated that the up-regulation of miR-155 expression was associated with advanced TNM clinical stage median 0.316 0.358 and 0.417 respectively for stage I II and III tumor P = 0.002 lymph node metastasis median 0.383 and 0.355 respectively for cases with positive and negative lymph nodes P = 0.034 higher proliferation index median 0.387 and 0.353 respectively for cases with high proliferation index Ki67 > 10% and low proliferation index Ki67 ≤ 10% P = 0.019 estrogen receptor-positive 0.367 and 0.318 respectively for cases with positive estrogen receptor and negative group P = 0.041 and progesterone receptor-positive 0.398 and 0.335 respectively for cases with positive progesterone receptor and negative group P = 0.029 in patients with breast cancer; The expression of miR-155 is up-regulated in primary breast cancer especially in patients with positive estrogen and progesterone receptor;While the expression of all three miRNAs was similar in samples from healthy women compared to those with breast cancer women with progesterone receptor PR p = 0.016 positive tumors had higher miR-155 expression than tumors that were negative for these receptors;miR 155 and miR 31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status; The expression levels of miR-155 but not miR-31 were inversely correlated with estrogen receptor ER and progesterone receptor PR expression ER r=-0.353 P=0.003; PR r=-0.357 P=0.003 staging;metastasis;; breast cancer;breast cancer;breast cancer hsa-miR-155-5p PHF21A 0.708423342476697 0.00686702252429413 -0.314340471617779 0.00621059979506441 mirMAP -0.141035504575912 6.97038344530536e-08 NA NA NA hsa-miR-155-5p PHGDH 0.708423342476697 0.00686702252429413 -1.22897863582309 9.22592634340078e-05 miRNAWalker2_validate -0.196624858497663 0.00783901742235741 NA NA NA hsa-miR-155-5p PKIA 0.708423342476697 0.00686702252429413 -1.26431427605 5.26373640576521e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.333635517976226 2.23923644505778e-07 NA NA NA hsa-miR-155-5p PLAG1 0.708423342476697 0.00686702252429413 -0.31457296228408 0.265316008070784 miRNATAP -0.167634312939319 0.0105967237924081 NA NA NA hsa-miR-155-5p PLEKHA1 0.708423342476697 0.00686702252429413 0.13326283541206 0.23636502532347 MirTarget -0.162983813821238 9.44567007380651e-11 NA NA NA hsa-miR-155-5p PLEKHA5 0.708423342476697 0.00686702252429413 -0.0209985094569882 0.878336125773638 miRNAWalker2_validate -0.204869373699057 2.20055364882021e-11 NA NA NA hsa-miR-155-5p PLEKHG4B 0.708423342476697 0.00686702252429413 -1.4425803087495 0.000248351299337546 mirMAP -0.397012827750655 1.42312981709392e-05 NA NA NA hsa-miR-155-5p PNPLA8 0.708423342476697 0.00686702252429413 -0.170996647160816 0.0543271550618377 miRNAWalker2_validate -0.160945638157504 9.29819548359852e-17 NA NA NA hsa-miR-155-5p PPARA 0.708423342476697 0.00686702252429413 -0.378523693756559 0.00547606509752035 mirMAP -0.149911827006302 1.62596128766595e-06 NA NA NA hsa-miR-155-5p PPFIBP1 0.708423342476697 0.00686702252429413 0.0806674750313388 0.54797471582341 miRNAWalker2_validate -0.161617425637752 1.09556480616791e-07 NA NA NA hsa-miR-155-5p PPL 0.708423342476697 0.00686702252429413 -0.714559147658576 0.024215440528081 miRNAWalker2_validate -0.403635610912535 2.28792996937579e-08 NA NA NA hsa-miR-155-5p PPM1L 0.708423342476697 0.00686702252429413 -0.537351176754866 0.00615520293012723 mirMAP -0.307198644716417 2.96098904728621e-12 NA NA NA hsa-miR-155-5p PPP1R9A 0.708423342476697 0.00686702252429413 -0.902560277535807 0.0425430977023791 mirMAP -0.586887242099952 6.38908642390578e-09 NA NA NA hsa-miR-155-5p PRKAR1A 0.708423342476697 0.00686702252429413 -0.0626576748573413 0.503137741080174 miRNAWalker2_validate -0.110018728164258 1.96566135128767e-07 NA NA NA hsa-miR-155-5p PRKAR2A 0.708423342476697 0.00686702252429413 -0.0807414545032392 0.4668186025327 miRNAWalker2_validate -0.121994576696711 1.3205614651211e-06 NA NA NA hsa-miR-155-5p PRKG1 0.708423342476697 0.00686702252429413 -0.561746760371328 0.0108057633457725 miRNATAP -0.421619093762882 2.11145005635013e-18 NA NA NA hsa-miR-155-5p PROX1 0.708423342476697 0.00686702252429413 0.561824633076836 0.184060987139057 miRNATAP -0.22085070778792 0.0249121586088267 NA NA NA hsa-miR-155-5p PRRG3 0.708423342476697 0.00686702252429413 -0.948195172898303 0.008851067571608 mirMAP -0.383277358678655 4.37166577867193e-06 NA NA NA hsa-miR-155-5p PTCHD1 0.708423342476697 0.00686702252429413 -2.90717877329561 5.21593618536946e-08 mirMAP -0.937738655161963 1.06122628740742e-14 NA NA NA hsa-miR-155-5p PTPRG 0.708423342476697 0.00686702252429413 0.765044621779042 5.69256181347512e-07 mirMAP -0.131206023664944 0.000270427000736667 NA NA NA hsa-miR-155-5p PURB 0.708423342476697 0.00686702252429413 0.191156761618797 0.0680497522728757 mirMAP -0.194091380855214 1.7204450473368e-17 NA NA NA hsa-miR-155-5p PYGL 0.708423342476697 0.00686702252429413 -0.168709465213612 0.49511945869553 miRNAWalker2_validate -0.156884346297345 0.00620951449850933 NA NA NA hsa-miR-155-5p QKI 0.708423342476697 0.00686702252429413 -0.332523081792703 0.0411054129206581 mirMAP -0.13292173538635 0.000413092234274368 NA NA NA hsa-miR-155-5p RAB11FIP2 0.708423342476697 0.00686702252429413 -0.259679029578217 0.0617021736002116 miRNAWalker2_validate;MirTarget;miRNATAP -0.212060242127261 8.7930184091357e-12 NA NA NA hsa-miR-155-5p RAB23 0.708423342476697 0.00686702252429413 -0.096112489735301 0.66521993302631 miRNAWalker2_validate -0.406548183875132 5.60310497054672e-17 NA NA NA hsa-miR-155-5p RAB34 0.708423342476697 0.00686702252429413 -0.44087405760989 0.0524102360243942 miRNAWalker2_validate;miRNATAP -0.219027525608828 2.85921303328667e-05 NA NA NA hsa-miR-155-5p RAB3C 0.708423342476697 0.00686702252429413 -1.07459718698808 0.0148779758106164 mirMAP -0.239848114639194 0.0200050007080942 NA NA NA hsa-miR-155-5p RAI14 0.708423342476697 0.00686702252429413 0.914484121281899 4.8090392612532e-10 miRNAWalker2_validate -0.187648070402968 5.35550497219709e-08 NA NA NA hsa-miR-155-5p RAP2A 0.708423342476697 0.00686702252429413 0.386291068354177 0.000539061271764718 mirMAP -0.115127132647348 7.69982245970339e-06 NA NA NA hsa-miR-155-5p RAPGEF4 0.708423342476697 0.00686702252429413 -0.234342130071581 0.20477654449334 miRNATAP -0.132060954574924 0.00201445826742658 NA NA NA hsa-miR-155-5p RBMS3 0.708423342476697 0.00686702252429413 -0.518802275066789 0.0355078319259322 MirTarget -0.390694705819491 1.42476929443404e-12 NA NA NA hsa-miR-155-5p RC3H1 0.708423342476697 0.00686702252429413 -0.0169576055444862 0.853509590236735 mirMAP -0.132320400737431 9.88316179475158e-11 NA NA NA hsa-miR-155-5p REPS2 0.708423342476697 0.00686702252429413 -0.101060745463859 0.602754903932931 MirTarget;miRNATAP -0.174786204821762 9.02856661240444e-05 NA NA NA hsa-miR-155-5p RGL1 0.708423342476697 0.00686702252429413 -0.442559496999595 0.0118773904815059 MirTarget -0.154188485454615 0.000151338978566896 NA NA NA hsa-miR-155-5p RICTOR 0.708423342476697 0.00686702252429413 0.387516049901938 0.00188233465370784 miRNAWalker2_validate;miRNATAP -0.165154675184658 5.63194510284189e-09 NA NA NA hsa-miR-155-5p RNF146 0.708423342476697 0.00686702252429413 -0.112404446941013 0.201866068894828 miRNATAP -0.135781020489801 3.4365687932219e-12 NA NA NA hsa-miR-155-5p RORA 0.708423342476697 0.00686702252429413 -0.888667376601635 4.99889595160793e-06 MirTarget;mirMAP;miRNATAP -0.235892750460117 1.71191343775086e-07 NA NA NA hsa-miR-155-5p RPRD1A 0.708423342476697 0.00686702252429413 -0.0372408248712572 0.772961680958764 miRNAWalker2_validate -0.194141011545795 1.51272667079073e-11 NA NA NA hsa-miR-155-5p RSF1 0.708423342476697 0.00686702252429413 0.263434916141246 0.0103951224612594 miRNAWalker2_validate -0.147515421331012 1.71828548022133e-10 NA NA NA hsa-miR-155-5p RSPO2 0.708423342476697 0.00686702252429413 -3.03817748898105 5.11795530924469e-10 miRNATAP -0.403924301931233 0.000558033365474012 NA NA NA hsa-miR-155-5p RUFY2 0.708423342476697 0.00686702252429413 0.000876674357667362 0.991796813092302 MirTarget -0.159691227200466 3.83333315579463e-18 NA NA NA hsa-miR-155-5p SATB1 0.708423342476697 0.00686702252429413 -0.899906881771092 2.24598761295463e-05 MirTarget;miRNATAP -0.299842777344866 6.8251985291408e-10 NA NA NA hsa-miR-155-5p SCAMP1 0.708423342476697 0.00686702252429413 -0.167386525129351 0.0888599426514571 miRNAWalker2_validate -0.148654208405178 1.16578298455446e-11 NA NA NA hsa-miR-155-5p SCG2 0.708423342476697 0.00686702252429413 -1.61108709867609 1.54072762110063e-05 MirTarget;miRNATAP -0.373079379325382 1.82029583342875e-05 NA NA NA hsa-miR-155-5p SCML2 0.708423342476697 0.00686702252429413 0.218188238977812 0.530973025458845 mirMAP -0.302053120505424 0.00016773860349803 NA NA NA hsa-miR-155-5p SCN9A 0.708423342476697 0.00686702252429413 -0.524729065320242 0.105932967952599 mirMAP -0.447661941329684 1.04021615182283e-09 NA NA NA hsa-miR-155-5p SCUBE2 0.708423342476697 0.00686702252429413 -2.170596660456 3.52055804528954e-12 MirTarget -0.410909859427508 2.85853059971595e-08 NA NA NA hsa-miR-155-5p SEC14L5 0.708423342476697 0.00686702252429413 -2.00691526440237 3.58158652448988e-07 miRNATAP -0.389102538609081 2.74716984035359e-05 NA NA NA hsa-miR-155-5p SELE 0.708423342476697 0.00686702252429413 0.662517529432636 0.0508837473525687 miRNAWalker2_validate -0.184413827146056 0.0197449448472047 NA NA NA hsa-miR-155-5p SERTAD4 0.708423342476697 0.00686702252429413 -0.855300469182066 0.00851964081929357 mirMAP -0.515641422982695 1.52111345626404e-12 NA NA NA hsa-miR-155-5p SGCB 0.708423342476697 0.00686702252429413 -0.278110445030599 0.0486812755185084 miRNATAP -0.216738455261064 6.2883614287349e-12 NA NA NA hsa-miR-155-5p SH3BP4 0.708423342476697 0.00686702252429413 0.519010066747448 0.00103013616580338 miRNAWalker2_validate -0.147222515434288 5.90445725605998e-05 NA NA NA hsa-miR-155-5p SKI 0.708423342476697 0.00686702252429413 0.22417153228759 0.0311770228305296 miRNAWalker2_validate;miRTarBase;miRNATAP -0.132164385997215 1.97964273590532e-08 21466664 MicroRNA 155 targets the SKI gene in human melanoma cell lines; Here we investigated whether miR-155 could mediate melanoma growth inhibition via SKI gene silencing; Luciferase reporter assays demonstrated that miR-155 interacted with SKI 3'UTR and impaired gene expression; Transfection of melanoma cells with miR-155 reduced SKI levels while inhibition of endogenous miR-155 up-regulated SKI expression; However melanoma cells over-expressing a 3'UTR-deleted SKI were still susceptible to the antiproliferative effect of miR-155; Our data demonstrate for the first time that SKI is a target of miR-155 in melanoma; However impairment of SKI expression is not the leading mechanism involved in the growth-suppressive effect of miR-155 found in this malignancy melanoma hsa-miR-155-5p SLAIN2 0.708423342476697 0.00686702252429413 -0.450230709640584 7.71615685568148e-08 mirMAP -0.133078429165932 2.64671990458484e-12 NA NA NA hsa-miR-155-5p SLC12A4 0.708423342476697 0.00686702252429413 0.125005446803168 0.374406724279442 miRNAWalker2_validate -0.17513412386492 3.88534495959238e-08 NA NA NA hsa-miR-155-5p SLC13A3 0.708423342476697 0.00686702252429413 -0.281208469302272 0.36469398737058 mirMAP -0.19018058489289 0.00826237065343633 NA NA NA hsa-miR-155-5p SLC16A7 0.708423342476697 0.00686702252429413 -1.78740503823139 7.82439110480803e-09 mirMAP -0.224214003832322 0.00242571291036684 NA NA NA hsa-miR-155-5p SLC20A2 0.708423342476697 0.00686702252429413 -0.28088699049617 0.0323486031823865 miRNATAP -0.174772548369586 3.92593927814539e-09 NA NA NA hsa-miR-155-5p SLC25A36 0.708423342476697 0.00686702252429413 0.0593410233712186 0.599897148453811 mirMAP -0.126330424120646 8.82313662186974e-07 NA NA NA hsa-miR-155-5p SLC30A4 0.708423342476697 0.00686702252429413 -0.916717603824858 1.25143222073552e-07 mirMAP -0.17685238328943 1.4378892632673e-05 NA NA NA hsa-miR-155-5p SLC7A2 0.708423342476697 0.00686702252429413 -0.504055476896812 0.159045414836461 mirMAP -0.401062794304156 9.60659059697589e-07 NA NA NA hsa-miR-155-5p SLMAP 0.708423342476697 0.00686702252429413 -0.731049756779606 4.09382011272657e-05 mirMAP -0.360281174799519 2.51032063093946e-20 NA NA NA hsa-miR-155-5p SMAD2 0.708423342476697 0.00686702252429413 -0.127583060413726 0.127322899257877 miRNAWalker2_validate;miRTarBase;MirTarget;mirMAP -0.104705142933411 2.71595551370121e-08 22426647;25283513 Taken together these data suggest that miR-155 may function as a tumor suppressor to regulate gastric cancer cell metastasis by targeting SMAD2 and its downregulation in gastric cancer cells may be partly ascribed to DNA methylation;MiR-155 which targeted the SMAD2-3'UTR decreased the expression and function of SMAD2 metastasis; gastric cancer;prostate cancer hsa-miR-155-5p SMAD4 0.708423342476697 0.00686702252429413 -0.31259096016241 0.0041260218763756 miRNAWalker2_validate -0.110361346500155 1.04894256533641e-05 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-155-5p SMAD5 0.708423342476697 0.00686702252429413 0.185272436777386 0.0565853388312257 miRNAWalker2_validate;miRTarBase -0.160194513669063 8.40729891931477e-14 20133617 Targeting of SMAD5 links microRNA 155 to the TGF beta pathway and lymphomagenesis; Using unbiased genome-wide approaches in DLBCL we discovered that the oncogenic microRNA-155 miR-155 directly targets the bone morphogenetic protein BMP-responsive transcriptional factor SMAD5; In confirmatory experiments RNAi-based SMAD5 knockdown recapitulated in vitro and in vivo the effects miR-155 overexpression; Furthermore in primary DLBCLs miR-155 overexpression inhibited SMAD5 expression and disrupted its activity as defined by individual and global analyses of its transcriptional targets; Together our data helped explain miR-155 function highlighted a hitherto unappreciated role of SMAD5 in lymphoma biology and defined a unique mechanism used by cancer cells to escape TGF-beta's growth-inhibitory effects lymphoma hsa-miR-155-5p SMAD9 0.708423342476697 0.00686702252429413 -1.3017262581652 4.19826165756804e-05 mirMAP -0.606348164922494 6.70068972872383e-18 NA NA NA hsa-miR-155-5p SNED1 0.708423342476697 0.00686702252429413 0.122555173975949 0.468426959436604 mirMAP -0.168901533040777 1.28143103867134e-05 NA NA NA hsa-miR-155-5p SORCS1 0.708423342476697 0.00686702252429413 -3.49208496111718 2.56798323400443e-11 MirTarget -0.546917304149492 1.25146207457438e-05 NA NA NA hsa-miR-155-5p SORT1 0.708423342476697 0.00686702252429413 -0.107011524251647 0.42103417000941 MirTarget -0.220739166564729 5.69028433039419e-14 NA NA NA hsa-miR-155-5p SOX10 0.708423342476697 0.00686702252429413 -2.91572852256965 8.62031299963275e-11 miRNATAP -0.577110330544346 5.41641751519688e-08 NA NA NA hsa-miR-155-5p SOX11 0.708423342476697 0.00686702252429413 2.67995156379045 3.65206596209455e-12 miRNATAP -0.324330051431727 0.000495686555503373 NA NA NA hsa-miR-155-5p SOX6 0.708423342476697 0.00686702252429413 -1.17584817693337 3.33834806230109e-05 miRTarBase;miRNATAP -0.2707476270648 4.29248424194864e-05 21989846 Ectopic expression of sex-determining region Y box 6 SOX6 was able to reverse the growth-promoting property of miR-155; Concordantly the results demonstrated for the first time that SOX6 is a direct target of miR-155; In addition a decline in p21waf1/cip1 expression caused by miR-155 could be reversed by SOX6 expression; The current data indicated that SOX6 is a novel target of miR-155 and that miR-155 enhances liver cell tumorigenesis at least in part through the novel miR-155/SOX6/p21waf1/cip1 axis tumorigenesis liver cancer hsa-miR-155-5p SPIN1 0.708423342476697 0.00686702252429413 0.234818085506331 0.008541450735538 miRNAWalker2_validate -0.172625733694698 4.161414342118e-19 NA NA NA hsa-miR-155-5p SPIRE1 0.708423342476697 0.00686702252429413 -0.140601295908568 0.528742219451626 mirMAP -0.308939182902966 8.00182557812674e-10 NA NA NA hsa-miR-155-5p SPRY3 0.708423342476697 0.00686702252429413 0.0161559202073591 0.912860324855943 mirMAP -0.141729307133639 2.77150996207712e-05 NA NA NA hsa-miR-155-5p ST8SIA3 0.708423342476697 0.00686702252429413 -2.91558860135036 1.52609950297091e-08 mirMAP -0.49958911784217 4.25893970613494e-05 NA NA NA hsa-miR-155-5p STIM1 0.708423342476697 0.00686702252429413 -0.671426317532005 1.4294751566811e-10 miRNAWalker2_validate -0.104559565034207 2.57133889142798e-05 NA NA NA hsa-miR-155-5p STK32A 0.708423342476697 0.00686702252429413 -1.77873554525927 0.000134135047560746 mirMAP -0.730989919173929 4.11543902024121e-12 NA NA NA hsa-miR-155-5p STK38L 0.708423342476697 0.00686702252429413 0.24425128467109 0.0779543983191778 mirMAP -0.159301758069613 4.5568183994471e-07 NA NA NA hsa-miR-155-5p STMN2 0.708423342476697 0.00686702252429413 -1.82580382670268 0.000431962151942936 miRNATAP -0.618339742933913 2.30174565595129e-07 NA NA NA hsa-miR-155-5p STOX2 0.708423342476697 0.00686702252429413 -1.38885793271292 7.68761182671221e-06 mirMAP -0.369392424434207 2.94150687451223e-07 NA NA NA hsa-miR-155-5p STRN3 0.708423342476697 0.00686702252429413 -0.14407563641855 0.145314550144892 MirTarget;miRNATAP -0.200621229935877 2.47838078297326e-21 NA NA NA hsa-miR-155-5p STXBP5L 0.708423342476697 0.00686702252429413 -1.77601007910107 1.66443977510419e-05 miRNATAP -0.626567923000965 2.66311971638008e-11 NA NA NA hsa-miR-155-5p SV2B 0.708423342476697 0.00686702252429413 -0.292959637600184 0.363390606978728 mirMAP -0.198299416301585 0.00803478902035683 NA NA NA hsa-miR-155-5p SYNE1 0.708423342476697 0.00686702252429413 -0.737828565382011 0.00316151426540844 mirMAP -0.216161098520293 0.000196446936675244 NA NA NA hsa-miR-155-5p SYT15 0.708423342476697 0.00686702252429413 -1.31160460302584 2.58607335214078e-06 mirMAP -0.288529516496326 9.85570987675489e-06 NA NA NA hsa-miR-155-5p TAB2 0.708423342476697 0.00686702252429413 -0.426442292317995 3.03594178765346e-06 miRNAWalker2_validate;miRTarBase -0.142599208357997 5.11298705077505e-12 NA NA NA hsa-miR-155-5p TAPT1 0.708423342476697 0.00686702252429413 -0.305011570601263 0.000951788137805319 MirTarget -0.100805209552014 1.877622349801e-06 NA NA NA hsa-miR-155-5p TCF4 0.708423342476697 0.00686702252429413 0.0159386247034305 0.922706223016712 miRNATAP -0.134907467236721 0.000361042133140625 NA NA NA hsa-miR-155-5p TFDP2 0.708423342476697 0.00686702252429413 -0.160784627018407 0.291450213121909 miRNATAP -0.279584598803917 4.39423015684543e-17 NA NA NA hsa-miR-155-5p THBS1 0.708423342476697 0.00686702252429413 0.740672313122665 0.00386405601476247 miRNAWalker2_validate;mirMAP -0.222886450295068 0.000180193487212198 NA NA NA hsa-miR-155-5p TJP1 0.708423342476697 0.00686702252429413 -0.131938594922226 0.315131821076645 miRNAWalker2_validate -0.246920638056317 4.96595424930935e-18 NA NA NA hsa-miR-155-5p TLE4 0.708423342476697 0.00686702252429413 -1.15702818127241 1.2267818242402e-11 miRNAWalker2_validate -0.136744329040018 0.00087870677605334 NA NA NA hsa-miR-155-5p TMEM132B 0.708423342476697 0.00686702252429413 -0.830474277127698 0.0108398389130459 mirMAP -0.493915080103378 1.69185258993169e-11 NA NA NA hsa-miR-155-5p TMEM245 0.708423342476697 0.00686702252429413 -0.242721302151875 0.0930172579576728 mirMAP -0.315213699805942 6.88371403754157e-25 NA NA NA hsa-miR-155-5p TMEM47 0.708423342476697 0.00686702252429413 -0.85850651693283 0.00027718244841934 mirMAP -0.381860549575402 6.79081751290245e-13 NA NA NA hsa-miR-155-5p TMOD2 0.708423342476697 0.00686702252429413 -0.644687820828108 0.00111217170460963 mirMAP -0.357923962874578 2.86689931870787e-16 NA NA NA hsa-miR-155-5p TMTC2 0.708423342476697 0.00686702252429413 -0.215072988059532 0.182480574270983 mirMAP -0.140537397847585 0.000154657969000334 NA NA NA hsa-miR-155-5p TMTC3 0.708423342476697 0.00686702252429413 0.122636432015445 0.221891077515614 miRNAWalker2_validate -0.137152828898619 1.13371098441273e-09 NA NA NA hsa-miR-155-5p TOMM20 0.708423342476697 0.00686702252429413 0.185705142779289 0.103320568980879 miRNAWalker2_validate;MirTarget;miRNATAP -0.10678096079733 4.40704870302911e-05 NA NA NA hsa-miR-155-5p TPBG 0.708423342476697 0.00686702252429413 0.369493271529142 0.0785185687561158 miRNAWalker2_validate -0.13983658941296 0.00412575825872097 NA NA NA hsa-miR-155-5p TRAK2 0.708423342476697 0.00686702252429413 -0.120950192085154 0.211315124945868 mirMAP -0.182388825972666 3.01659829207441e-18 NA NA NA hsa-miR-155-5p TRIM2 0.708423342476697 0.00686702252429413 -0.138593633483852 0.426294696378046 miRNATAP -0.135837976379291 0.000725993247322628 NA NA NA hsa-miR-155-5p TRIM23 0.708423342476697 0.00686702252429413 -0.342721432687234 0.00211580921154758 MirTarget -0.176263498037357 1.58366735027796e-12 NA NA NA hsa-miR-155-5p TRIO 0.708423342476697 0.00686702252429413 0.709506263927999 2.17818099879629e-06 miRNAWalker2_validate -0.19812037476376 9.77885554920356e-09 NA NA NA hsa-miR-155-5p TRIQK 0.708423342476697 0.00686702252429413 0.136261461046469 0.299193759989079 MirTarget -0.117467377528713 9.68695371819955e-05 NA NA NA hsa-miR-155-5p TROVE2 0.708423342476697 0.00686702252429413 0.200938654746773 0.0450246702407811 miRNAWalker2_validate -0.167285573786298 4.05124765009381e-14 NA NA NA hsa-miR-155-5p TRPS1 0.708423342476697 0.00686702252429413 -0.190955899174114 0.441089792195844 MirTarget;mirMAP -0.379451319959489 7.33778940024761e-12 NA NA NA hsa-miR-155-5p TSC1 0.708423342476697 0.00686702252429413 0.103376413669437 0.260710731616936 mirMAP -0.102631949573312 8.39615862659847e-07 NA NA NA hsa-miR-155-5p TSHZ3 0.708423342476697 0.00686702252429413 -0.556373800983045 0.0151607966428605 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.332446608439739 1.27864307365464e-10 NA NA NA hsa-miR-155-5p TSPAN5 0.708423342476697 0.00686702252429413 -1.05916819146055 6.72366925707668e-07 MirTarget -0.179047966139093 0.000369604756295967 NA NA NA hsa-miR-155-5p TTC21B 0.708423342476697 0.00686702252429413 0.218949158239465 0.0422280171667745 MirTarget -0.142107532235284 5.21692816333239e-09 NA NA NA hsa-miR-155-5p TTC37 0.708423342476697 0.00686702252429413 -0.253622025446208 0.013825945953052 miRNAWalker2_validate -0.115232334261545 9.48743826766483e-07 NA NA NA hsa-miR-155-5p TYRP1 0.708423342476697 0.00686702252429413 0.493161056912956 0.260932234532277 MirTarget -0.256276985376771 0.011958526771298 26068396 SNPs at miR 155 binding sites of TYRP1 explain discrepancy between mRNA and protein and refine TYRP1 prognostic value in melanoma; The effect of miR-155 on TYRP1 mRNA/protein expression was evaluated in two melanoma cell lines harbouring matched or mismatched miR-155-TYRP1 mRNA interaction after transfection with pre-miR-155; In parallel 192 skin and lymph node melanoma metastases were examined for TYRP1 mRNA/protein miR-155 and SNPs and correlated with patient survival; TYRP1 mRNA SNPs at its 3'UTR and miR-155 were analysed by RT-qPCR whereas TYRP1 protein was evaluated by western blot in cell lines and by immunohistochemistry in metastatic tissues; The miR-155 induced a dose-dependent TYRP1 mRNA decay and hampered its translation into protein in the line with the 'match' genotype; In melanoma metastases TYRP1 mRNA inversely correlated with miR-155 expression but not with TYRP1 protein in the 'match' group whereas it positively correlated with protein but not with miR-155 in the 'mismatch' group; Polymorphisms in 3'UTR of TYRP1 mRNA can affect TYRP1 mRNA regulation by miR-155 and its subsequent translation into protein; These SNPs can render TYRP1 mRNA and protein expression nonsusceptible to miR-155 activity and disclose a prognostic value for TYRP1 protein in a subgroup of melanoma patients metastasis;poor survival melanoma hsa-miR-155-5p UBE2H 0.708423342476697 0.00686702252429413 0.0273387763409909 0.772766398379207 miRNAWalker2_validate -0.140039230028051 2.88994961524781e-11 NA NA NA hsa-miR-155-5p UBN2 0.708423342476697 0.00686702252429413 0.424732444065439 0.000143636953961984 mirMAP -0.103563440537414 6.44088517758617e-05 NA NA NA hsa-miR-155-5p UBQLN2 0.708423342476697 0.00686702252429413 -0.0676586504190544 0.445944131914115 miRNAWalker2_validate -0.114838764654621 8.29337319637149e-09 NA NA NA hsa-miR-155-5p UBR1 0.708423342476697 0.00686702252429413 0.155410458148927 0.121926043011426 mirMAP -0.119317050187194 1.59295694171113e-07 NA NA NA hsa-miR-155-5p UBR3 0.708423342476697 0.00686702252429413 -0.0206777423176625 0.827742242328184 miRNATAP -0.181940501956452 6.17942608723602e-19 NA NA NA hsa-miR-155-5p UBXN2B 0.708423342476697 0.00686702252429413 0.327813841384824 0.00202369927290284 MirTarget -0.118274429206031 1.16745557553887e-06 NA NA NA hsa-miR-155-5p UNC80 0.708423342476697 0.00686702252429413 -1.93440601889881 3.16732101418133e-06 MirTarget -0.419173519222339 1.62255398445256e-05 NA NA NA hsa-miR-155-5p UST 0.708423342476697 0.00686702252429413 -1.41394764597586 8.19742145654322e-06 miRNATAP -0.283189777586793 0.000140703217293655 NA NA NA hsa-miR-155-5p VEZF1 0.708423342476697 0.00686702252429413 -0.128939695446817 0.142752999653342 miRNAWalker2_validate -0.161771042593713 2.33732570593649e-17 NA NA NA hsa-miR-155-5p VGLL3 0.708423342476697 0.00686702252429413 0.314863164469675 0.263033597488497 mirMAP -0.197796533810566 0.00240609588428682 NA NA NA hsa-miR-155-5p VPS13B 0.708423342476697 0.00686702252429413 0.355265011270777 0.00171278261576175 mirMAP -0.130486297536313 4.90123641174625e-07 NA NA NA hsa-miR-155-5p VPS36 0.708423342476697 0.00686702252429413 -0.0139641287928525 0.883320541434469 miRNAWalker2_validate -0.10059309074767 3.23249581458843e-06 NA NA NA hsa-miR-155-5p WDFY3 0.708423342476697 0.00686702252429413 -0.20090024293122 0.0966993995672952 miRNATAP -0.187468284349493 3.4477959654583e-12 NA NA NA hsa-miR-155-5p WNK1 0.708423342476697 0.00686702252429413 -0.0928178691135297 0.446606934438845 miRNATAP -0.115384420080452 3.57849109812736e-05 NA NA NA hsa-miR-155-5p WNK3 0.708423342476697 0.00686702252429413 -0.566384750663729 0.0267756841098298 miRNATAP -0.433689389007807 2.2022350622876e-14 NA NA NA hsa-miR-155-5p WNT5A 0.708423342476697 0.00686702252429413 0.829517033807399 0.000132972934926195 miRNAWalker2_validate;mirMAP -0.114796461161049 0.024682569382517 NA NA NA hsa-miR-155-5p WWTR1 0.708423342476697 0.00686702252429413 -0.344530111808307 0.119970728404188 mirMAP -0.384074115552449 4.09368032537386e-15 NA NA NA hsa-miR-155-5p YIPF6 0.708423342476697 0.00686702252429413 -0.0394638057162524 0.620395306693598 mirMAP -0.121921679932837 4.2802698103641e-12 NA NA NA hsa-miR-155-5p ZBTB10 0.708423342476697 0.00686702252429413 0.11491226178643 0.650172271983559 mirMAP -0.355680813690125 4.4354262951031e-10 NA NA NA hsa-miR-155-5p ZC3H12B 0.708423342476697 0.00686702252429413 -0.250832462540052 0.257150410374074 mirMAP -0.338899257813982 7.42144191469676e-12 NA NA NA hsa-miR-155-5p ZDHHC15 0.708423342476697 0.00686702252429413 -1.35902684957062 3.39400626126344e-06 mirMAP -0.469315490017822 1.71953455956839e-12 NA NA NA hsa-miR-155-5p ZFAND5 0.708423342476697 0.00686702252429413 -0.409420327651102 4.50112739233377e-05 mirMAP -0.154210244163412 9.72092976261687e-12 NA NA NA hsa-miR-155-5p ZFHX4 0.708423342476697 0.00686702252429413 0.0184972294773713 0.955736809911936 miRNATAP -0.422353129444104 2.26970250777314e-08 NA NA NA hsa-miR-155-5p ZMYM2 0.708423342476697 0.00686702252429413 0.278969072922853 0.0127298205019214 MirTarget;miRNATAP -0.160549805355154 1.83908062412074e-10 NA NA NA hsa-miR-155-5p ZNF248 0.708423342476697 0.00686702252429413 -0.0574258532196534 0.651465511774278 miRNAWalker2_validate -0.238945888427875 4.59543797847439e-18 NA NA NA hsa-miR-155-5p ZNF254 0.708423342476697 0.00686702252429413 -0.163078671895383 0.389588344600487 miRNAWalker2_validate -0.230010282324091 9.17063707429555e-08 NA NA NA hsa-miR-155-5p ZNF264 0.708423342476697 0.00686702252429413 0.218529896508938 0.129998637685212 mirMAP -0.14162263786979 1.88071781103505e-05 NA NA NA hsa-miR-155-5p ZNF273 0.708423342476697 0.00686702252429413 0.35893895201972 0.00459018824906637 miRNAWalker2_validate -0.101751326544401 0.000525297852774659 NA NA NA hsa-miR-155-5p ZNF354C 0.708423342476697 0.00686702252429413 -0.968356214536449 0.000383478594843384 mirMAP -0.314468136919908 5.76691345061862e-07 NA NA NA hsa-miR-155-5p ZNF493 0.708423342476697 0.00686702252429413 -0.390755127852871 0.0299344842560846 miRNAWalker2_validate -0.127440303778816 0.00228537993180734 NA NA NA hsa-miR-155-5p ZNF518B 0.708423342476697 0.00686702252429413 -0.810348186681662 0.0007591643900906 MirTarget;miRNATAP -0.211753754142422 0.000155907799390484 NA NA NA hsa-miR-155-5p ZNF528 0.708423342476697 0.00686702252429413 -0.885064244446873 0.000427142801293249 mirMAP -0.256137735322993 1.0963427551619e-05 NA NA NA hsa-miR-155-5p ZNF611 0.708423342476697 0.00686702252429413 0.510852970968197 0.000202281561904424 miRNAWalker2_validate -0.113959694653611 0.000374070077582743 NA NA NA hsa-miR-155-5p ZNF677 0.708423342476697 0.00686702252429413 -1.19588042263771 1.66267978030496e-06 mirMAP -0.329449893234268 1.15042188725475e-08 NA NA NA hsa-miR-155-5p ZNF703 0.708423342476697 0.00686702252429413 0.865599355591785 0.000101971661916777 miRNATAP -0.301348161316037 3.47354678208502e-09 NA NA NA hsa-miR-155-5p ZNF793 0.708423342476697 0.00686702252429413 -1.09057837455347 0.000314123281952348 mirMAP -0.306028338830925 1.32477351766938e-05 NA NA NA hsa-miR-155-5p ZNF829 0.708423342476697 0.00686702252429413 -0.806605652699805 0.000605618293534488 mirMAP -0.307081621281354 1.16071725910815e-08 NA NA NA hsa-miR-155-5p ZNF83 0.708423342476697 0.00686702252429413 0.0682718832832605 0.703680659223551 miRNAWalker2_validate -0.163564782319586 7.27669358357944e-05 NA NA NA hsa-miR-155-5p ZNF880 0.708423342476697 0.00686702252429413 -0.986350932570258 0.000330834791337815 MirTarget -0.341201962204388 6.56809589416254e-08 NA NA NA hsa-miR-155-5p ZNRF3 0.708423342476697 0.00686702252429413 0.63712078410009 0.00172201182527305 miRNATAP -0.21480136571189 4.67659414775066e-06 NA NA NA hsa-miR-155-5p ZSWIM6 0.708423342476697 0.00686702252429413 -0.433553897728624 1.52139610356126e-05 MirTarget -0.107219152018412 3.79296552971544e-06 NA NA NA