miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-3p ACTL6A 0.167285443861993 0.431834813181487 0.81151404521516 1.74053907352887e-08 MirTarget -0.127952251031943 0.000306703844944076 NA NA NA hsa-let-7a-3p ACTR3 0.167285443861993 0.431834813181487 0.282402981254185 0.0117756271114791 MirTarget;miRNATAP -0.117113144449768 1.54066351771671e-05 NA NA NA hsa-let-7a-5p AKT2 -1.37014061604018 3.11451492971224e-14 0.158500088541505 0.113504798741429 TargetScan -0.119930037553526 1.13227688326527e-06 NA NA NA hsa-miR-29a-3p AKT2 0.101650412194573 0.573201097011668 0.158500088541505 0.113504798741429 MirTarget -0.104368014677354 4.26511869332683e-05 24076586 Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis acute myeloid leukemia hsa-miR-106b-5p AKT3 1.47447672652218 1.32004094930462e-13 -1.44031241124732 2.576504600149e-09 miRNATAP -0.158920731526324 0.00425859940487133 NA NA NA hsa-miR-107 AKT3 0.658676029898313 5.11480446318819e-07 -1.44031241124732 2.576504600149e-09 PITA;miRanda -0.256548300142307 0.00309702957622585 NA NA NA hsa-miR-146b-5p AKT3 1.0922867893808 5.63754607494775e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate -0.14508398550335 0.00188822517544197 NA NA NA hsa-miR-15a-5p AKT3 1.62575353599172 1.55312121019827e-19 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.412918804091755 4.08840965026726e-12 NA NA NA hsa-miR-16-5p AKT3 0.749619098384047 4.11649450706988e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.269698520974258 9.94440318719177e-05 NA NA NA hsa-miR-17-3p AKT3 1.36706429551147 4.60388403547821e-13 -1.44031241124732 2.576504600149e-09 miRNATAP -0.150903286752378 0.0102655088674849 NA NA NA hsa-miR-17-5p AKT3 2.07078488653279 2.77403038572568e-19 -1.44031241124732 2.576504600149e-09 TargetScan;miRNATAP -0.217476886844258 3.56953935954486e-06 NA NA NA hsa-miR-181a-5p AKT3 -0.375429731222937 0.0562142867129802 -1.44031241124732 2.576504600149e-09 miRNATAP -0.22550600060725 9.19470016250579e-05 NA NA NA hsa-miR-181b-5p AKT3 0.668793269169928 0.000239998092406404 -1.44031241124732 2.576504600149e-09 miRNATAP -0.367498754199467 2.09865276667175e-09 NA NA NA hsa-miR-20a-5p AKT3 2.64649625616975 5.1469418982085e-27 -1.44031241124732 2.576504600149e-09 miRNATAP -0.24430728120197 1.27608550819212e-08 NA NA NA hsa-miR-22-3p AKT3 1.42501909916631 1.72295005910055e-25 -1.44031241124732 2.576504600149e-09 miRNATAP -0.259390140878921 0.0010937362716222 NA NA NA hsa-miR-28-3p AKT3 0.387144500601444 0.00777919765254534 -1.44031241124732 2.576504600149e-09 miRNATAP -0.197315516871575 0.0122556173898666 NA NA NA hsa-miR-29a-3p AKT3 0.101650412194573 0.573201097011668 -1.44031241124732 2.576504600149e-09 miRNATAP -0.147280324253872 0.0201558550795979 NA NA NA hsa-miR-29b-2-5p AKT3 0.345881055247341 0.194842633194187 -1.44031241124732 2.576504600149e-09 mirMAP -0.181342398720756 1.80199534450665e-05 NA NA NA hsa-miR-29b-3p AKT3 3.10527711861309 3.01242507282711e-32 -1.44031241124732 2.576504600149e-09 miRNATAP -0.267243460090773 1.17871192498365e-11 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 0.653308707552535 0.0999497219778851 -1.44031241124732 2.576504600149e-09 mirMAP -0.18242132898273 2.34990243224026e-09 NA NA NA hsa-miR-335-3p AKT3 1.51116383169018 6.88553098788624e-13 -1.44031241124732 2.576504600149e-09 mirMAP -0.134576700675304 0.0106735082003925 NA NA NA hsa-miR-362-5p AKT3 0.658947634569393 0.0243306847205756 -1.44031241124732 2.576504600149e-09 PITA;TargetScan;miRNATAP -0.229571357984291 4.43564207755877e-09 NA NA NA hsa-miR-542-3p AKT3 1.62226640768239 2.6427102465476e-10 -1.44031241124732 2.576504600149e-09 miRanda -0.186790699816246 1.44501888663791e-05 NA NA NA hsa-miR-93-5p AKT3 1.50844106515467 1.83836866996875e-12 -1.44031241124732 2.576504600149e-09 miRNATAP -0.251105283811718 1.01733106411986e-06 NA NA NA hsa-let-7a-3p ARL1 0.167285443861993 0.431834813181487 0.223065549917697 0.0617067431152647 miRNATAP -0.105435256819499 0.000264717148870659 NA NA NA hsa-let-7a-3p ARL5A 0.167285443861993 0.431834813181487 -0.16745954849603 0.162902795032042 MirTarget;mirMAP -0.110183944889467 0.000146254772327048 NA NA NA hsa-let-7a-3p ASPH 0.167285443861993 0.431834813181487 0.48749681109473 0.0836624579335295 mirMAP -0.154110121058608 0.0250500890464626 NA NA NA hsa-let-7a-3p ASXL2 0.167285443861993 0.431834813181487 -0.304319336802245 0.128373105979599 mirMAP;miRNATAP -0.13540933697393 0.00544360814749144 NA NA NA hsa-let-7a-3p ATAD5 0.167285443861993 0.431834813181487 1.77912218223544 1.44998356719356e-14 MirTarget -0.127704130749669 0.0280410983834343 NA NA NA hsa-let-7a-3p ATE1 0.167285443861993 0.431834813181487 -0.47280882035676 0.0117725834713204 mirMAP -0.149551191771816 0.00106768120735345 NA NA NA hsa-let-7a-3p ATF1 0.167285443861993 0.431834813181487 -0.101119390509551 0.431685017035591 MirTarget -0.145226203034891 2.72991862976324e-06 NA NA NA hsa-let-7a-3p ATF2 0.167285443861993 0.431834813181487 0.0108252986583377 0.936889208236278 MirTarget;mirMAP;miRNATAP -0.128835404212926 9.65527356851969e-05 NA NA NA hsa-let-7a-3p ATP13A3 0.167285443861993 0.431834813181487 0.413231080115787 0.00634383048699373 mirMAP -0.127077342659857 0.000558912065688319 NA NA NA hsa-let-7a-3p ATP2B1 0.167285443861993 0.431834813181487 -0.523388206823699 0.00592395003205013 MirTarget;miRNATAP -0.102310896390273 0.0277501202552747 NA NA NA hsa-let-7a-3p BACH1 0.167285443861993 0.431834813181487 -0.383239514470123 0.00633377747958556 MirTarget;mirMAP -0.124818025965279 0.000252181420963107 NA NA NA hsa-let-7a-3p BAG4 0.167285443861993 0.431834813181487 -0.0916523536087714 0.604802387005939 mirMAP -0.150637143041917 0.000450986772853343 NA NA NA hsa-let-7a-3p BMP2K 0.167285443861993 0.431834813181487 -0.40743322509616 0.0174677193279028 mirMAP -0.100631606653836 0.0161161000211225 NA NA NA hsa-let-7a-3p BRIP1 0.167285443861993 0.431834813181487 2.42394083227288 8.71000427847812e-16 MirTarget -0.239235563426911 0.0015956111204818 NA NA NA hsa-let-7a-3p BST1 0.167285443861993 0.431834813181487 -1.69017615366689 5.35746158099181e-13 MirTarget -0.148742636899881 0.0111446341328521 NA NA NA hsa-let-7a-3p C1QBP 0.167285443861993 0.431834813181487 0.426301342883511 0.00667883003747465 MirTarget -0.115155683891138 0.00263646625764481 NA NA NA hsa-let-7a-3p C2orf49 0.167285443861993 0.431834813181487 0.439903277371628 0.000327773680864027 mirMAP -0.131205116530183 1.00258060482991e-05 NA NA NA hsa-let-7a-3p C4orf32 0.167285443861993 0.431834813181487 -1.32427128841596 4.4094616170278e-13 mirMAP -0.11918873403603 0.00912874772344949 NA NA NA hsa-let-7a-3p CACNA2D1 0.167285443861993 0.431834813181487 -1.26894428990152 0.00468562348387855 mirMAP -0.246160481393511 0.0250500809636637 NA NA NA hsa-let-7a-3p CALCB 0.167285443861993 0.431834813181487 0.772952220831376 0.21300742203805 mirMAP -0.349818034977116 0.0208900639227235 NA NA NA hsa-let-7a-3p CAND1 0.167285443861993 0.431834813181487 0.377909407153972 0.00711384535896279 MirTarget;mirMAP -0.108071085315123 0.00156184208142545 NA NA NA hsa-let-7a-3p CAPZA2 0.167285443861993 0.431834813181487 -0.437173062107471 0.00974806119014026 MirTarget -0.175426649813229 1.887557828733e-05 NA NA NA hsa-let-7a-3p CCNA2 0.167285443861993 0.431834813181487 2.68958557277422 1.76349887174632e-19 MirTarget -0.232834253775044 0.00207347391725921 NA NA NA hsa-let-7a-3p CCNE2 0.167285443861993 0.431834813181487 2.14869777933212 3.82193505863706e-13 mirMAP -0.219072556802333 0.00307083362438944 NA NA NA hsa-let-7a-3p CEP76 0.167285443861993 0.431834813181487 0.444824785333193 0.0024972407341442 MirTarget -0.149907731974796 2.6810029972438e-05 NA NA NA hsa-miR-106b-5p CHP2 1.47447672652218 1.32004094930462e-13 -0.698246795377642 0.27546655425478 MirTarget -0.289307563984085 0.046059718658527 NA NA NA hsa-miR-582-5p CHP2 1.08286181406653 0.00149040450161757 -0.698246795377642 0.27546655425478 miRNATAP -0.174545230260245 0.0486087191670937 NA NA NA hsa-let-7a-3p COL4A1 0.167285443861993 0.431834813181487 -0.171188584989235 0.444957041661407 miRNATAP -0.117776389029474 0.0310306967712091 NA NA NA hsa-let-7a-3p CORO1C 0.167285443861993 0.431834813181487 -1.10607374904599 5.96590230557236e-14 MirTarget;miRNATAP -0.139100936034551 0.000151644034144976 NA NA NA hsa-let-7a-3p CPD 0.167285443861993 0.431834813181487 0.911876479581357 9.08443596366211e-05 mirMAP;miRNATAP -0.22637388143698 6.90678098073407e-05 NA NA NA hsa-let-7a-3p CXADR 0.167285443861993 0.431834813181487 -0.217640758864026 0.358080442573993 miRNATAP -0.158016344404853 0.00611100636878062 NA NA NA hsa-let-7a-3p CYP1B1 0.167285443861993 0.431834813181487 -0.30280425105966 0.285993324885712 mirMAP -0.144295392874498 0.0371097835651721 NA NA NA hsa-let-7a-3p DCUN1D1 0.167285443861993 0.431834813181487 0.144235891193565 0.301323427210419 mirMAP -0.121474130798149 0.000324629983764161 NA NA NA hsa-let-7a-3p DENND1B 0.167285443861993 0.431834813181487 0.30743091435244 0.0729798031357219 mirMAP -0.115238040685164 0.00575869913057636 NA NA NA hsa-let-7a-3p DEPDC1 0.167285443861993 0.431834813181487 3.4453193569446 8.88810549846053e-21 mirMAP -0.30571334852754 0.00111363477267663 NA NA NA hsa-let-7a-3p DR1 0.167285443861993 0.431834813181487 -0.0220738604255635 0.852691434467995 MirTarget -0.127886498158711 7.91098241459467e-06 NA NA NA hsa-let-7a-3p E2F8 0.167285443861993 0.431834813181487 3.41861987328154 1.01467543166977e-29 MirTarget -0.193447978121826 0.0138803917118013 NA NA NA hsa-let-7a-3p EIF2AK2 0.167285443861993 0.431834813181487 0.620787530289015 8.73480825216513e-05 MirTarget -0.110380608282311 0.00438121207546669 NA NA NA hsa-let-7a-3p ELOVL2 0.167285443861993 0.431834813181487 0.698353746492753 0.0558689246539879 miRNATAP -0.21230182850866 0.0172710193364187 NA NA NA hsa-let-7a-3p ELOVL6 0.167285443861993 0.431834813181487 0.819759240003576 0.0278715609826653 mirMAP -0.260699003640483 0.00414919507560012 NA NA NA hsa-let-7a-3p ELOVL7 0.167285443861993 0.431834813181487 -0.306244869115949 0.301624536451902 miRNATAP -0.170580227320533 0.0182538572548317 NA NA NA hsa-let-7a-3p ENPP4 0.167285443861993 0.431834813181487 -0.715806208745597 0.000134785023608672 mirMAP -0.101788193826214 0.0269119076297394 NA NA NA hsa-let-7a-3p ESRP1 0.167285443861993 0.431834813181487 1.06002388227634 7.47407517307077e-08 MirTarget -0.104229714457705 0.0324404123942168 NA NA NA hsa-let-7a-3p EVI2A 0.167285443861993 0.431834813181487 -0.973339001029267 9.4456921194346e-05 MirTarget -0.15283496973188 0.0124936089091044 NA NA NA hsa-let-7a-3p EXO1 0.167285443861993 0.431834813181487 3.42411170163395 3.12173497397742e-22 MirTarget -0.243452099964484 0.00702890267731416 NA NA NA hsa-let-7a-3p FAM126A 0.167285443861993 0.431834813181487 0.131520649887173 0.583592264369936 MirTarget -0.181954868919985 0.00180506197966556 NA NA NA hsa-let-7a-3p FAM199X 0.167285443861993 0.431834813181487 0.788148993932119 9.46860038929325e-09 MirTarget;miRNATAP -0.103812882982949 0.00218313375541956 NA NA NA hsa-let-7a-3p FGF12 0.167285443861993 0.431834813181487 -0.540341291347842 0.2437250465075 MirTarget -0.251674811310452 0.0260531720786865 NA NA NA hsa-let-7a-3p FOXN2 0.167285443861993 0.431834813181487 -0.361267840844799 0.00691613331182303 MirTarget;miRNATAP -0.150703370015032 3.15577983247053e-06 NA NA NA hsa-let-7a-3p FRMD3 0.167285443861993 0.431834813181487 -3.3223201712006 4.66197750212244e-24 mirMAP;miRNATAP -0.224248793281481 0.00785353734124146 NA NA NA hsa-let-7a-3p FUT4 0.167285443861993 0.431834813181487 0.107443908511892 0.548914360535474 mirMAP -0.118601737984307 0.00649613971201876 NA NA NA hsa-let-7a-3p FZD5 0.167285443861993 0.431834813181487 -0.705926982163628 0.000105007898539503 miRNATAP -0.115040442140511 0.00992055050107584 NA NA NA hsa-let-7a-3p GDF11 0.167285443861993 0.431834813181487 0.0309067719540748 0.870921178086618 mirMAP -0.114067274351757 0.0137030708612526 NA NA NA hsa-let-7a-3p GDPD1 0.167285443861993 0.431834813181487 0.782691103630107 0.000333003715889842 MirTarget -0.165500221006287 0.00192348726285934 NA NA NA hsa-let-7a-3p GLDC 0.167285443861993 0.431834813181487 1.58796623512874 0.00240241206740079 MirTarget -0.318853797121103 0.0128054502845951 NA NA NA hsa-let-7a-3p GLS 0.167285443861993 0.431834813181487 -0.27948241182068 0.296755425153891 miRNATAP -0.1727124950555 0.00810259518718448 NA NA NA hsa-let-7a-3p GNA13 0.167285443861993 0.431834813181487 -0.133272744410812 0.249127006322313 MirTarget -0.123585044387411 9.1818552170688e-06 NA NA NA hsa-let-7a-3p GPRIN3 0.167285443861993 0.431834813181487 -1.10112258399518 3.09572277363753e-05 MirTarget;mirMAP -0.219499744958453 0.000701150549357391 NA NA NA hsa-let-7a-3p GSTCD 0.167285443861993 0.431834813181487 0.417705203164416 0.00332972495157295 mirMAP -0.107702587222104 0.0018879644509735 NA NA NA hsa-let-7a-3p GTF2A1 0.167285443861993 0.431834813181487 -0.142611004472868 0.488196504262934 MirTarget;miRNATAP -0.142970031393742 0.00426154877810672 NA NA NA hsa-let-7a-3p GXYLT1 0.167285443861993 0.431834813181487 -0.113487406764996 0.379415681385523 mirMAP -0.106575026247182 0.000652241328343122 NA NA NA hsa-let-7a-3p HCFC2 0.167285443861993 0.431834813181487 -0.624484023383398 5.73742971687797e-07 miRNATAP -0.118227357284171 0.000110306162451866 NA NA NA hsa-let-7a-3p HFE 0.167285443861993 0.431834813181487 -0.0464799990276235 0.818380304616866 mirMAP -0.125610313273457 0.010749803136045 NA NA NA hsa-let-7a-3p HGF 0.167285443861993 0.431834813181487 -1.46782534168535 1.69011867186688e-05 mirMAP -0.220233871328952 0.00866054421617636 NA NA NA hsa-let-7a-3p HOXC8 0.167285443861993 0.431834813181487 1.00265205326374 0.0838848520448804 miRNATAP -0.308090004663017 0.0296592239483646 NA NA NA hsa-let-7a-5p HRAS -1.37014061604018 3.11451492971224e-14 0.139800610267073 0.358123351398595 miRNAWalker2_validate;miRTarBase -0.142144334211175 0.000164893588817854 18344688;20033209;20607356;23134218;19323605 Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;;progression lung cancer;lung cancer;glioblastoma;lung squamous cell cancer;pancreatic cancer hsa-miR-143-3p HRAS -1.21021691908494 5.70938667332876e-06 0.139800610267073 0.358123351398595 miRNAWalker2_validate;miRTarBase -0.125376896055055 1.11873626270013e-06 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-let-7a-3p ID2 0.167285443861993 0.431834813181487 -1.25480152265325 4.20094211960508e-09 miRNATAP -0.135279074251097 0.0105817726040694 NA NA NA hsa-let-7a-3p IGFBP1 0.167285443861993 0.431834813181487 0.070281099555725 0.915149044259044 MirTarget -0.34418868909245 0.032401648824225 NA NA NA hsa-let-7a-3p IL6ST 0.167285443861993 0.431834813181487 -1.39734012929419 9.70680145490152e-07 mirMAP -0.176020254923391 0.0123719691947882 NA NA NA hsa-let-7a-3p IMPAD1 0.167285443861993 0.431834813181487 0.0917866744195983 0.481682586474374 MirTarget -0.125744867107464 6.60229999921155e-05 NA NA NA hsa-let-7a-3p IPMK 0.167285443861993 0.431834813181487 -0.0198047604525582 0.93735196239987 mirMAP -0.257806603831337 2.34969482563336e-05 NA NA NA hsa-let-7a-3p ITM2C 0.167285443861993 0.431834813181487 0.983034669012217 5.98792505956222e-07 MirTarget -0.183556130600852 0.000146457685050641 NA NA NA hsa-miR-940 JMJD7-PLA2G4B 0.011138136211269 0.974925352379525 -0.400430522628583 0.0339399904766164 miRNATAP -0.117383627060937 1.87570641851953e-05 NA NA NA hsa-let-7a-3p KBTBD8 0.167285443861993 0.431834813181487 -0.819220520736755 0.000290306039417183 mirMAP -0.141157327077802 0.0108393065722646 NA NA NA hsa-miR-15a-5p KDR 1.62575353599172 1.55312121019827e-19 -1.29217133319599 5.17137540720335e-06 miRNATAP -0.277469551547698 8.30946725476635e-05 NA NA NA hsa-miR-16-5p KDR 0.749619098384047 4.11649450706988e-06 -1.29217133319599 5.17137540720335e-06 miRTarBase;miRNATAP -0.302391399126077 0.000178613946334273 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2 colorectal cancer hsa-miR-19b-1-5p KDR 1.71217036351784 3.28561659177495e-12 -1.29217133319599 5.17137540720335e-06 miRNAWalker2_validate -0.215943064538471 0.000357453344573502 NA NA NA hsa-miR-200c-3p KDR 0.380533388300368 0.0842181838538353 -1.29217133319599 5.17137540720335e-06 miRNATAP -0.266060212567765 8.13005514869735e-06 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-429 KDR 2.3794516574089 1.72813419703734e-13 -1.29217133319599 5.17137540720335e-06 PITA;miRanda;miRNATAP -0.111419145999383 0.00975571919411248 NA NA NA hsa-miR-590-3p KDR 0.83851360565783 0.00129224433453587 -1.29217133319599 5.17137540720335e-06 miRanda -0.242141052927696 5.91937848623311e-05 NA NA NA hsa-miR-590-5p KDR 2.07441240363458 4.95240551694843e-14 -1.29217133319599 5.17137540720335e-06 miRanda -0.245958719964099 1.91688320565153e-05 NA NA NA hsa-let-7a-3p KRAS 0.167285443861993 0.431834813181487 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.165605931792738 5.41329968030116e-05 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-let-7b-3p KRAS -1.81889978084306 6.9913416210266e-19 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.21045052897075 5.92266664846517e-09 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;26581910;22584434;26516699;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS;Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA;Interestingly the differential expression of miRNA in mice also corroborated with the miRNA expression in human PC cell lines and tissue samples; ectopic expression of Let-7b in CD18/HPAF and Capan1 cells resulted in the downregulation of KRAS and MSST1 expression;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;;;; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;pancreatic cancer;lung squamous cell cancer hsa-miR-1-3p KRAS -1.48412019995919 0.000242034342580425 0.538115716643554 0.00142410994615815 MirTarget -0.1135101654678 3.65182035802432e-08 NA NA NA hsa-miR-126-3p KRAS 0.397563736477277 0.115641762947829 0.538115716643554 0.00142410994615815 miRNAWalker2_validate;miRTarBase -0.140662247102959 4.48695871977096e-06 22845403 miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK pancreatic cancer hsa-miR-1271-5p KRAS -0.0172769786790662 0.951102370899887 0.538115716643554 0.00142410994615815 MirTarget -0.111352851066065 6.81606802337118e-05 NA NA NA hsa-miR-140-3p KRAS -1.11373309124537 8.35257079443689e-14 0.538115716643554 0.00142410994615815 MirTarget -0.379051955627805 3.51513569284386e-14 NA NA NA hsa-miR-155-5p KRAS 0.813513839059142 0.000608282725633232 0.538115716643554 0.00142410994615815 miRNAWalker2_validate;miRNATAP -0.136672576377435 2.71388112053399e-05 NA NA NA hsa-miR-16-1-3p KRAS 1.50034693398929 6.63958242991125e-10 0.538115716643554 0.00142410994615815 mirMAP -0.120692099076156 0.0020633534672843 NA NA NA hsa-miR-181a-5p KRAS -0.375429731222937 0.0562142867129802 0.538115716643554 0.00142410994615815 miRNAWalker2_validate -0.232892392323763 2.90389285591447e-09 24098024;27517749;26124189 The KRAS mutational status was determined by pyrosequencing and miR-181a expression was measured by quantitative RT-PCR in CRC tumour tissue and corresponding non-neoplastic colon tissue;Here we report that miR-181a directly binds to 3'-untranslated regions UTRs; downregulates KRAS NRAS and MAPK1; and decreases AML growth; The delivery of miR-181a mimics to target AML cells using transferrin-targeting lipopolyplex nanoparticles NP increased mature miR-181a; downregulated KRAS NRAS and MAPK1; and resulted in decreased phosphorylation of the downstream RAS effectors;MiR 181a 5p inhibits cell proliferation and migration by targeting Kras in non small cell lung cancer A549 cells; Luciferase activity assay results demonstrated that two binding sites of Kras could be directly targeted by miR-181a-5p; Furthermore Kras was down-regulated by miR-181a-5p at both transcriptional and translational levels; SiRNA-mediated Kras down-regulation could mimic the effects of miR-181a-5p mimic in A549 cells; Our findings suggest that miR-181a-5p plays a potential role in tumor suppression by partially targeting Kras and has the potential therapeutic application in NSCLC patients ;; colorectal cancer;acute myeloid leukemia;lung squamous cell cancer hsa-miR-181c-5p KRAS 0.529875814537156 0.0125885822998008 0.538115716643554 0.00142410994615815 miRNAWalker2_validate;miRTarBase -0.113481461651682 0.00199940913466899 NA NA NA hsa-miR-186-5p KRAS 0.852175445703945 6.88885738584309e-10 0.538115716643554 0.00142410994615815 mirMAP -0.173206213582145 0.0020136892983084 NA NA NA hsa-miR-193a-3p KRAS 0.549173467360291 0.0319030569365466 0.538115716643554 0.00142410994615815 MirTarget;miRanda;miRNATAP -0.114033878061734 0.000545245334645599 NA NA NA hsa-miR-193a-5p KRAS -1.15938257046946 2.61709321247277e-08 0.538115716643554 0.00142410994615815 miRNATAP -0.136206451672479 0.000220728848496 NA NA NA hsa-miR-195-3p KRAS -1.33068822339418 6.65427393047357e-09 0.538115716643554 0.00142410994615815 mirMAP -0.26052009331858 1.37547972270525e-15 NA NA NA hsa-miR-199a-5p KRAS 1.3057193856884 2.38429382751645e-08 0.538115716643554 0.00142410994615815 miRanda;miRNATAP -0.190569403157002 4.12804905993219e-09 NA NA NA hsa-miR-199b-5p KRAS 2.13822205171062 4.56262988762436e-15 0.538115716643554 0.00142410994615815 miRanda;miRNATAP -0.160083363830103 4.62674745647173e-09 27517624 The miR-199b prognostic impact was particularly evident in both younger and KRAS wild-type subgroups colorectal cancer hsa-miR-224-3p KRAS 0.921090817288022 0.010010047721564 0.538115716643554 0.00142410994615815 mirMAP -0.11580794239374 2.34601235413632e-07 25919696 MicroRNA 224 is associated with colorectal cancer progression and response to 5 fluorouracil based chemotherapy by KRAS dependent and independent mechanisms; MicroRNA-224 was differentially expressed in dysplastic colorectal disease and in isogeneic KRAS WT and mutant HCT116 cells; 5-FU chemosensitivity was significantly increased in miR-224 knockdown cells and in NIH3T3 cells expressing KRAS and BRAF mutant proteins progression;drug resistance colorectal cancer hsa-miR-27b-3p KRAS 0.236438984240408 0.12263510345883 0.538115716643554 0.00142410994615815 miRNATAP -0.140671332847896 0.00626162133896643 NA NA NA hsa-miR-30a-3p KRAS -2.54042202792785 2.9111625410859e-18 0.538115716643554 0.00142410994615815 MirTarget;miRNATAP -0.122460927678546 1.58218389307393e-06 NA NA NA hsa-miR-30a-5p KRAS -0.924084264430689 0.000762030454634728 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.160923145065632 7.88859261457886e-09 NA NA NA hsa-miR-30b-5p KRAS 0.358144314839612 0.138026229059594 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.147252408030935 4.51771159246383e-06 NA NA NA hsa-miR-30c-5p KRAS -0.327319105755825 0.123595832152687 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.303491851342304 1.38338910293015e-17 22701724 Deregulated miRNAs in hereditary breast cancer revealed a role for miR 30c in regulating KRAS oncogene; In particular we experimentally validated KRAS as a miR-30c target; Luciferase assays confirmed that miR-30c binds the 3'UTR of KRAS transcripts and expression of pre-miR-30c down-regulated KRAS mRNA and protein; In addition we provide evidence that KRAS is a target of miR-30c and that this miRNA suppresses breast cancer cell growth potentially through inhibition of KRAS signaling breast cancer hsa-miR-30d-3p KRAS 0.00396376345349925 0.986457040013182 0.538115716643554 0.00142410994615815 MirTarget;miRNATAP -0.12073831042602 0.00128170411687249 NA NA NA hsa-miR-30d-5p KRAS -0.920901858717441 3.50898334321668e-05 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.124035278299491 0.000357846902820112 NA NA NA hsa-miR-30e-3p KRAS -0.104420043859122 0.526240453209293 0.538115716643554 0.00142410994615815 MirTarget -0.254543853548427 7.09600327106139e-08 NA NA NA hsa-miR-30e-5p KRAS 1.60414100786743 3.78951090573667e-19 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.125942634043968 0.00267795482717309 NA NA NA hsa-miR-501-3p KRAS -0.0405952693028064 0.866802243505833 0.538115716643554 0.00142410994615815 MirTarget;PITA;TargetScan;miRNATAP -0.124338029852589 0.000111299015637681 NA NA NA hsa-miR-502-3p KRAS -0.262270070977708 0.161760375279961 0.538115716643554 0.00142410994615815 MirTarget;PITA;miRNATAP -0.116432061546502 0.00538025775498572 NA NA NA hsa-miR-532-5p KRAS 0.576620898517708 0.0023245812680956 0.538115716643554 0.00142410994615815 MirTarget;PITA;miRNATAP -0.123485597460216 0.00273306142385404 NA NA NA hsa-let-7a-3p LARP4 0.167285443861993 0.431834813181487 0.162815723487127 0.180310644656097 mirMAP -0.107991479751942 0.000239213254936648 NA NA NA hsa-let-7a-3p LCOR 0.167285443861993 0.431834813181487 0.637403193132661 0.0037407933451203 mirMAP;miRNATAP -0.135058263662586 0.0119735509341834 NA NA NA hsa-let-7a-3p LEPROTL1 0.167285443861993 0.431834813181487 -0.337645394023175 0.00371525369570826 mirMAP -0.100003529913722 0.000401178702821883 NA NA NA hsa-let-7a-3p LIMS1 0.167285443861993 0.431834813181487 -0.704394644273366 0.000151942952769563 mirMAP -0.154818061995388 0.000658598259957072 NA NA NA hsa-let-7a-3p LIN7A 0.167285443861993 0.431834813181487 -3.21006870221094 6.07828486409009e-20 mirMAP -0.177502962285367 0.0472752931672409 NA NA NA hsa-let-7a-3p LIN9 0.167285443861993 0.431834813181487 0.604373356351849 0.000213205413176905 MirTarget;miRNATAP -0.107858801077198 0.00693516046901633 NA NA NA hsa-let-7a-3p LRRC40 0.167285443861993 0.431834813181487 0.143177438088414 0.267382893543522 mirMAP -0.112882794228364 0.000302507265251577 NA NA NA hsa-let-7a-3p MAN1A1 0.167285443861993 0.431834813181487 -1.13807684251551 2.25783767570692e-06 MirTarget -0.210067608463074 0.000377502155395726 NA NA NA hsa-miR-30c-5p MAP2K1 -0.327319105755825 0.123595832152687 -0.126507255559492 0.255813608366235 miRNAWalker2_validate -0.148243346155614 3.94199903529302e-10 NA NA NA hsa-miR-497-5p MAP2K1 -0.0546347378264729 0.786205564901684 -0.126507255559492 0.255813608366235 miRNAWalker2_validate -0.146950542279665 4.9483059880063e-09 NA NA NA hsa-let-7a-3p MAP4K3 0.167285443861993 0.431834813181487 0.222249126286683 0.0537519877977262 mirMAP -0.131165600825336 2.29639133687973e-06 NA NA NA hsa-miR-130a-3p MAPK1 0.881660100597014 0.000158893668519248 -0.313704159534906 0.0065740365500908 mirMAP -0.101872197195 5.97373126035408e-06 NA NA NA hsa-miR-140-5p MAPK1 0.669142684153918 0.000335928403032308 -0.313704159534906 0.0065740365500908 miRanda -0.105360739553965 0.000299450445528468 NA NA NA hsa-miR-148a-3p MAPK1 2.30885799126944 1.95226081368985e-21 -0.313704159534906 0.0065740365500908 mirMAP -0.102558880400122 7.51166113357563e-07 NA NA NA hsa-miR-24-1-5p MAPK1 0.856025727237819 0.000107354490323658 -0.313704159534906 0.0065740365500908 mirMAP -0.114103342147363 5.37066958548902e-06 NA NA NA hsa-miR-29a-5p MAPK1 1.89519956688438 1.03453349363915e-11 -0.313704159534906 0.0065740365500908 mirMAP -0.100646824836984 5.49015969248301e-06 NA NA NA hsa-miR-29b-3p MAPK1 3.10527711861309 3.01242507282711e-32 -0.313704159534906 0.0065740365500908 mirMAP -0.122356815748067 3.56933939779318e-11 NA NA NA hsa-miR-342-3p MAPK1 -0.128691966564961 0.561034080130801 -0.313704159534906 0.0065740365500908 miRanda;mirMAP -0.137175460423021 7.76879946497687e-09 NA NA NA hsa-miR-34a-5p MAPK1 1.40588612517769 8.60097477768592e-12 -0.313704159534906 0.0065740365500908 mirMAP -0.105828142272272 2.59913448288353e-05 NA NA NA hsa-miR-454-3p MAPK1 1.49453641052169 4.46235742871434e-09 -0.313704159534906 0.0065740365500908 mirMAP -0.104171229052281 2.01455003951624e-05 NA NA NA hsa-let-7a-5p MAPK11 -1.37014061604018 3.11451492971224e-14 -0.745899193823322 0.000735900736408196 miRNAWalker2_validate -0.125621236574903 0.0235024688693135 NA NA NA hsa-let-7a-3p MAPK8 0.167285443861993 0.431834813181487 0.0632162214250305 0.668341664440464 mirMAP -0.157930246462243 9.14454944313728e-06 NA NA NA hsa-miR-128-3p MAPKAPK3 1.03509868349735 2.11606310588315e-10 -0.348682372957655 0.0255209675217176 MirTarget -0.213442860654922 7.98428808357436e-07 NA NA NA hsa-miR-421 MAPKAPK3 0.170525317701774 0.535277026680289 -0.348682372957655 0.0255209675217176 miRanda -0.105470928337545 0.000199541167159307 NA NA NA hsa-let-7a-3p MARCH1 0.167285443861993 0.431834813181487 -0.824409643214186 0.000632454870282737 miRNATAP -0.197954687464177 0.000782684125870478 NA NA NA hsa-let-7a-3p MGAT4A 0.167285443861993 0.431834813181487 -0.482465143207374 0.00555570284492783 mirMAP -0.197418802270806 2.7874521943875e-06 NA NA NA hsa-let-7a-3p MTBP 0.167285443861993 0.431834813181487 1.74869876238573 7.89265007908619e-14 MirTarget -0.131310951557503 0.0253229700065598 NA NA NA hsa-let-7a-3p MYBL1 0.167285443861993 0.431834813181487 1.04822336925959 3.66689691140016e-05 mirMAP;miRNATAP -0.197890451059614 0.00148175312810565 NA NA NA hsa-let-7a-3p N4BP2 0.167285443861993 0.431834813181487 0.355404739664865 0.102531617115281 mirMAP -0.157448252973671 0.00295937208861816 NA NA NA hsa-let-7a-3p NEDD1 0.167285443861993 0.431834813181487 0.210162472136981 0.0954133160680262 mirMAP -0.111486728538464 0.000258893431901379 NA NA NA hsa-miR-130b-5p NFAT5 1.53645187062942 1.10498816261505e-08 -0.409853693095821 0.00241772915052018 MirTarget;miRNATAP -0.108561642446117 1.60834322577139e-06 NA NA NA hsa-miR-132-3p NFAT5 0.0122601212105202 0.934032846062939 -0.409853693095821 0.00241772915052018 miRNATAP -0.12963519248744 0.00233856127647591 NA NA NA hsa-miR-148b-3p NFAT5 0.483970528590224 0.0026495409465901 -0.409853693095821 0.00241772915052018 miRNATAP -0.112577222828241 0.0038126543774256 NA NA NA hsa-miR-27b-5p NFAT5 1.03511957999268 7.86187917705303e-11 -0.409853693095821 0.00241772915052018 miRNATAP -0.16192960419066 2.57829034468637e-05 NA NA NA hsa-miR-590-3p NFAT5 0.83851360565783 0.00129224433453587 -0.409853693095821 0.00241772915052018 MirTarget;miRanda;mirMAP;miRNATAP -0.115936168805103 4.65917004279092e-05 NA NA NA hsa-miR-590-5p NFAT5 2.07441240363458 4.95240551694843e-14 -0.409853693095821 0.00241772915052018 PITA;mirMAP;miRNATAP -0.125507198595402 3.73504850114134e-06 NA NA NA hsa-miR-93-5p NFAT5 1.50844106515467 1.83836866996875e-12 -0.409853693095821 0.00241772915052018 MirTarget;miRNATAP -0.118263351694996 2.99203468201362e-05 NA NA NA hsa-miR-3127-5p NFATC1 0.382717393698386 0.11535780874721 -1.1375752288108 4.2403023117592e-09 MirTarget -0.111363856377225 0.00286268272528884 NA NA NA hsa-miR-421 NFATC1 0.170525317701774 0.535277026680289 -1.1375752288108 4.2403023117592e-09 miRanda -0.27250878649941 5.59172029209645e-15 NA NA NA hsa-miR-130b-5p NFATC2 1.53645187062942 1.10498816261505e-08 -1.17929519652878 0.000402858371584528 MirTarget -0.172861973245698 0.00221822037960357 NA NA NA hsa-miR-16-2-3p NFATC2 0.503964803530872 0.0263648405197492 -1.17929519652878 0.000402858371584528 mirMAP -0.178407692112819 0.0160148740478749 NA NA NA hsa-miR-182-5p NFATC2 3.21839823004635 5.13049145201115e-39 -1.17929519652878 0.000402858371584528 mirMAP -0.180422957533554 0.00169761028088969 NA NA NA hsa-miR-185-5p NFATC2 1.14291034858482 2.95777119743491e-13 -1.17929519652878 0.000402858371584528 MirTarget -0.360674698099435 0.00018867412489729 NA NA NA hsa-miR-186-5p NFATC2 0.852175445703945 6.88885738584309e-10 -1.17929519652878 0.000402858371584528 mirMAP -0.343079979359603 0.00202223937894896 NA NA NA hsa-miR-193b-5p NFATC2 0.179695858885499 0.55521472494233 -1.17929519652878 0.000402858371584528 MirTarget -0.117977647957471 0.0203484714641141 NA NA NA hsa-miR-19a-3p NFATC2 2.11776595911517 7.07663078397156e-10 -1.17929519652878 0.000402858371584528 mirMAP -0.336569537886002 7.83772096103092e-11 NA NA NA hsa-miR-19b-3p NFATC2 2.10868505662119 5.40846613768389e-17 -1.17929519652878 0.000402858371584528 mirMAP -0.37856857138205 7.5498987798628e-10 NA NA NA hsa-miR-2355-3p NFATC2 1.10676344164715 6.24068383465151e-06 -1.17929519652878 0.000402858371584528 mirMAP -0.219356663156956 0.000875934214021124 NA NA NA hsa-miR-2355-5p NFATC2 1.86174980095465 3.47492783095613e-13 -1.17929519652878 0.000402858371584528 MirTarget -0.126259768387679 0.048425095193218 NA NA NA hsa-miR-24-3p NFATC2 -0.0357874587555003 0.785865078836504 -1.17929519652878 0.000402858371584528 MirTarget -0.294004659472517 0.0138398550638032 NA NA NA hsa-miR-29a-5p NFATC2 1.89519956688438 1.03453349363915e-11 -1.17929519652878 0.000402858371584528 mirMAP;miRNATAP -0.177982407502831 0.00605902966456155 NA NA NA hsa-miR-30b-5p NFATC2 0.358144314839612 0.138026229059594 -1.17929519652878 0.000402858371584528 MirTarget;mirMAP -0.200783588972738 0.00170730601229697 NA NA NA hsa-miR-30e-5p NFATC2 1.60414100786743 3.78951090573667e-19 -1.17929519652878 0.000402858371584528 MirTarget -0.193712402291355 0.0200156921807788 NA NA NA hsa-miR-320b NFATC2 0.226640952564488 0.378818692487242 -1.17929519652878 0.000402858371584528 MirTarget -0.136739507087094 0.0230483252413662 NA NA NA hsa-miR-335-3p NFATC2 1.51116383169018 6.88553098788624e-13 -1.17929519652878 0.000402858371584528 mirMAP -0.153264362499494 0.0330110805376744 NA NA NA hsa-miR-3613-5p NFATC2 0.0237159233591191 0.934730899070298 -1.17929519652878 0.000402858371584528 mirMAP -0.24336416775385 0.000133096294572765 NA NA NA hsa-miR-590-3p NFATC2 0.83851360565783 0.00129224433453587 -1.17929519652878 0.000402858371584528 mirMAP -0.264991647100287 0.000176914211247844 NA NA NA hsa-miR-9-5p NFATC2 4.99250901331516 2.59132733422801e-19 -1.17929519652878 0.000402858371584528 MirTarget -0.105804655043001 6.44752588454657e-05 NA NA NA hsa-miR-15a-5p NFATC3 1.62575353599172 1.55312121019827e-19 -0.775339809160321 2.42596775036985e-09 MirTarget;miRNATAP -0.194760431797607 1.31515520866454e-09 NA NA NA hsa-miR-185-5p NFATC3 1.14291034858482 2.95777119743491e-13 -0.775339809160321 2.42596775036985e-09 MirTarget;miRNATAP -0.243443371940348 7.87569812717632e-11 NA NA NA hsa-miR-21-3p NFATC3 2.54206008030157 1.11598785398763e-30 -0.775339809160321 2.42596775036985e-09 MirTarget -0.144436369277164 1.38631470692728e-08 NA NA NA hsa-miR-29b-3p NFATC3 3.10527711861309 3.01242507282711e-32 -0.775339809160321 2.42596775036985e-09 MirTarget;miRNATAP -0.113008786184003 1.1536763111009e-07 NA NA NA hsa-miR-335-3p NFATC3 1.51116383169018 6.88553098788624e-13 -0.775339809160321 2.42596775036985e-09 mirMAP -0.104848301816004 0.000194709438293604 NA NA NA hsa-miR-589-3p NFATC3 1.34253876396688 1.84935927493927e-05 -0.775339809160321 2.42596775036985e-09 mirMAP -0.123021593670604 2.81638805309194e-10 NA NA NA hsa-miR-590-3p NFATC3 0.83851360565783 0.00129224433453587 -0.775339809160321 2.42596775036985e-09 miRanda -0.142048821132892 2.6995336752082e-07 NA NA NA hsa-miR-185-3p NFATC4 -0.377490365509078 0.093653288903368 0.936688963651323 2.59723598381625e-05 MirTarget -0.154954243253114 0.00074408877001007 NA NA NA hsa-miR-423-5p NFATC4 -1.80309342242719 1.34791344187441e-19 0.936688963651323 2.59723598381625e-05 miRNATAP -0.21075464541514 2.27046521867108e-05 NA NA NA hsa-let-7a-3p NR5A2 0.167285443861993 0.431834813181487 -1.63747659369463 2.38318834529012e-11 miRNATAP -0.228011658356383 0.00017874033880608 NA NA NA hsa-miR-145-5p NRAS -1.34926078156437 2.63526538800669e-07 0.110922789912811 0.412920190999736 miRNAWalker2_validate;MirTarget;miRNATAP -0.142760374746012 6.05977027346954e-10 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-148a-3p NRAS 2.30885799126944 1.95226081368985e-21 0.110922789912811 0.412920190999736 MirTarget -0.109343012733505 6.98144190286614e-06 NA NA NA hsa-miR-195-3p NRAS -1.33068822339418 6.65427393047357e-09 0.110922789912811 0.412920190999736 mirMAP -0.160994991063139 1.05944502094987e-09 NA NA NA hsa-miR-22-3p NRAS 1.42501909916631 1.72295005910055e-25 0.110922789912811 0.412920190999736 MirTarget;miRNATAP -0.128848632159027 0.00314401368706814 NA NA NA hsa-miR-26b-5p NRAS 0.72362441215247 4.7794659748036e-05 0.110922789912811 0.412920190999736 mirMAP;miRNATAP -0.130094780209659 0.000185700963505737 NA NA NA hsa-miR-27b-3p NRAS 0.236438984240408 0.12263510345883 0.110922789912811 0.412920190999736 miRNATAP -0.154582178613336 0.000157756473886806 NA NA NA hsa-miR-29a-3p NRAS 0.101650412194573 0.573201097011668 0.110922789912811 0.412920190999736 miRNATAP -0.156058827596967 6.08074898827527e-06 NA NA NA hsa-miR-29b-3p NRAS 3.10527711861309 3.01242507282711e-32 0.110922789912811 0.412920190999736 miRNATAP -0.130094390329954 2.14950403130123e-09 NA NA NA hsa-miR-29c-3p NRAS 1.32354490728858 1.84279305179762e-07 0.110922789912811 0.412920190999736 miRNATAP -0.132620598651339 2.93062944029642e-08 NA NA NA hsa-miR-320a NRAS -0.961144925954715 1.62478794429204e-08 0.110922789912811 0.412920190999736 mirMAP -0.138653847620251 0.000123789780187142 NA NA NA hsa-miR-502-3p NRAS -0.262270070977708 0.161760375279961 0.110922789912811 0.412920190999736 MirTarget -0.116067692488029 0.000491333225482351 NA NA NA hsa-miR-664a-3p NRAS 0.443077463053857 0.0214248925850984 0.110922789912811 0.412920190999736 MirTarget -0.339669060778621 8.1321923374988e-29 NA NA NA hsa-let-7a-3p NRIP1 0.167285443861993 0.431834813181487 0.0607277502606074 0.722985105808803 miRNATAP -0.132497151319195 0.00143723953702112 NA NA NA hsa-let-7a-3p NRP1 0.167285443861993 0.431834813181487 -0.40252187730616 0.0377253868964042 miRNATAP -0.160589833526336 0.000651050503769306 NA NA NA hsa-let-7a-3p OSBPL8 0.167285443861993 0.431834813181487 -0.274759084934151 0.0362087351984716 mirMAP;miRNATAP -0.130194737988887 4.09912642849077e-05 NA NA NA hsa-let-7a-3p PAFAH1B2 0.167285443861993 0.431834813181487 -0.288598670796801 0.087837950354388 mirMAP -0.121803703219156 0.00305378489225299 NA NA NA hsa-let-7a-3p PAQR3 0.167285443861993 0.431834813181487 0.332616070529975 0.0602616885748928 mirMAP -0.116362691697394 0.00695035458115824 NA NA NA hsa-let-7a-3p PCNP 0.167285443861993 0.431834813181487 -0.239383575875887 0.0184607411279603 MirTarget -0.100785797928813 3.99103429609382e-05 NA NA NA hsa-let-7a-3p PECR 0.167285443861993 0.431834813181487 -0.652008620500552 0.00190870578676897 MirTarget -0.125018313204409 0.0149787504847869 NA NA NA hsa-let-7a-3p PEG10 0.167285443861993 0.431834813181487 -1.59152448479029 0.00410467550132011 mirMAP -0.3112115324869 0.0219081675200968 NA NA NA hsa-miR-186-5p PIK3CA 0.852175445703945 6.88885738584309e-10 -0.335143841150832 0.0107695904000801 mirMAP -0.158211833933772 0.000271764939125213 NA NA NA hsa-miR-501-5p PIK3CA 0.411357595674671 0.10435288464149 -0.335143841150832 0.0107695904000801 mirMAP -0.12161859871495 2.80222388365699e-07 NA NA NA hsa-miR-96-5p PIK3CA 3.0381097138467 4.40362891630201e-24 -0.335143841150832 0.0107695904000801 TargetScan -0.126074442438012 7.26672594996813e-09 NA NA NA hsa-miR-454-3p PIK3CB 1.49453641052169 4.46235742871434e-09 0.0520424688078016 0.708498300848208 miRNATAP -0.107092855274913 0.000279808925292599 NA NA NA hsa-miR-421 PIK3CD 0.170525317701774 0.535277026680289 -0.165252183051274 0.400815192488832 miRanda -0.187035284767016 1.2803934448503e-07 NA NA NA hsa-miR-148b-3p PIK3CG 0.483970528590224 0.0026495409465901 -1.19325793461087 5.28114748039233e-05 miRNAWalker2_validate -0.239430332797948 0.00515332606189168 NA NA NA hsa-miR-26b-5p PIK3CG 0.72362441215247 4.7794659748036e-05 -1.19325793461087 5.28114748039233e-05 miRNAWalker2_validate -0.285401672500096 0.000198071700272844 NA NA NA hsa-miR-29b-3p PIK3CG 3.10527711861309 3.01242507282711e-32 -1.19325793461087 5.28114748039233e-05 miRTarBase -0.13454994451672 0.00563635188925694 NA NA NA hsa-miR-335-3p PIK3CG 1.51116383169018 6.88553098788624e-13 -1.19325793461087 5.28114748039233e-05 mirMAP -0.273824058387904 1.51960031354635e-05 NA NA NA hsa-miR-542-3p PIK3CG 1.62226640768239 2.6427102465476e-10 -1.19325793461087 5.28114748039233e-05 miRanda -0.188110029792226 0.000315799878113487 NA NA NA hsa-miR-106a-5p PIK3R1 1.3902608059488 6.07931522284525e-05 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.152594260668069 8.26964346589391e-10 NA NA NA hsa-miR-106b-5p PIK3R1 1.47447672652218 1.32004094930462e-13 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.274486784039244 3.92361901886501e-13 NA NA NA hsa-miR-107 PIK3R1 0.658676029898313 5.11480446318819e-07 -1.28526113405546 1.1596112892202e-14 MirTarget;PITA;miRanda;miRNATAP -0.134608742116129 0.0261488734968106 NA NA NA hsa-miR-128-3p PIK3R1 1.03509868349735 2.11606310588315e-10 -1.28526113405546 1.1596112892202e-14 MirTarget -0.262733562571172 2.81828198129055e-08 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 0.845987603184611 0.000579808501723616 -1.28526113405546 1.1596112892202e-14 MirTarget -0.252566507630763 3.89638206850943e-16 NA NA NA hsa-miR-15a-5p PIK3R1 1.62575353599172 1.55312121019827e-19 -1.28526113405546 1.1596112892202e-14 MirTarget -0.198845640675418 2.2459439580454e-06 NA NA NA hsa-miR-16-2-3p PIK3R1 0.503964803530872 0.0263648405197492 -1.28526113405546 1.1596112892202e-14 MirTarget -0.215346374588015 7.85659740371802e-09 NA NA NA hsa-miR-16-5p PIK3R1 0.749619098384047 4.11649450706988e-06 -1.28526113405546 1.1596112892202e-14 MirTarget -0.14663084031301 0.00245632583144358 NA NA NA hsa-miR-17-5p PIK3R1 2.07078488653279 2.77403038572568e-19 -1.28526113405546 1.1596112892202e-14 MirTarget;TargetScan;miRNATAP -0.30827377198364 1.00416866782136e-22 NA NA NA hsa-miR-182-5p PIK3R1 3.21839823004635 5.13049145201115e-39 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.153577568348738 1.31399000956901e-07 NA NA NA hsa-miR-185-5p PIK3R1 1.14291034858482 2.95777119743491e-13 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.266123472564886 5.49627003455298e-08 NA NA NA hsa-miR-186-5p PIK3R1 0.852175445703945 6.88885738584309e-10 -1.28526113405546 1.1596112892202e-14 mirMAP -0.266496146428416 2.3226235073163e-06 NA NA NA hsa-miR-200c-3p PIK3R1 0.380533388300368 0.0842181838538353 -1.28526113405546 1.1596112892202e-14 mirMAP -0.174738637328334 9.22364461849854e-07 NA NA NA hsa-miR-20a-5p PIK3R1 2.64649625616975 5.1469418982085e-27 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.268255645046992 2.93530513676098e-20 NA NA NA hsa-miR-21-5p PIK3R1 4.38165933891779 1.52536633902505e-92 -1.28526113405546 1.1596112892202e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.239855941401679 1.66617444081141e-16 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 1.71436244278242 9.85038001236064e-15 -1.28526113405546 1.1596112892202e-14 mirMAP -0.249170402831725 1.77307790115702e-13 NA NA NA hsa-miR-29b-3p PIK3R1 3.10527711861309 3.01242507282711e-32 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.169264704761152 8.1620915503371e-10 NA NA NA hsa-miR-335-3p PIK3R1 1.51116383169018 6.88553098788624e-13 -1.28526113405546 1.1596112892202e-14 mirMAP -0.174731000503181 1.56931158200611e-06 NA NA NA hsa-miR-424-5p PIK3R1 1.26485330287919 6.1498991028257e-06 -1.28526113405546 1.1596112892202e-14 MirTarget -0.120660860108298 1.41199550729587e-05 NA NA NA hsa-miR-450b-5p PIK3R1 1.69248953402469 1.96052058003353e-07 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.105483872062601 7.60035078150308e-05 NA NA NA hsa-miR-582-5p PIK3R1 1.08286181406653 0.00149040450161757 -1.28526113405546 1.1596112892202e-14 mirMAP -0.121659359408152 1.98808465862233e-07 NA NA NA hsa-miR-589-3p PIK3R1 1.34253876396688 1.84935927493927e-05 -1.28526113405546 1.1596112892202e-14 mirMAP -0.110115880585781 1.73041185531321e-05 NA NA NA hsa-miR-590-3p PIK3R1 0.83851360565783 0.00129224433453587 -1.28526113405546 1.1596112892202e-14 miRanda;mirMAP -0.21433969556349 1.93094554722457e-09 NA NA NA hsa-miR-590-5p PIK3R1 2.07441240363458 4.95240551694843e-14 -1.28526113405546 1.1596112892202e-14 MirTarget;PITA;miRanda;miRNATAP -0.297606057222883 4.39734655384069e-19 NA NA NA hsa-miR-629-3p PIK3R1 1.31892116211001 0.000114487182853678 -1.28526113405546 1.1596112892202e-14 MirTarget -0.155200085033098 2.2200629415611e-10 NA NA NA hsa-miR-93-5p PIK3R1 1.50844106515467 1.83836866996875e-12 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.302548872464343 3.62432128460294e-18 NA NA NA hsa-miR-96-5p PIK3R1 3.0381097138467 4.40362891630201e-24 -1.28526113405546 1.1596112892202e-14 TargetScan;miRNATAP -0.247820034174453 4.28366535969023e-19 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.71024742617744 3.64915691793611e-09 -0.993075734580867 1.37876508579496e-06 mirMAP -0.137607471527013 2.02669327816331e-05 NA NA NA hsa-miR-335-3p PIK3R3 1.51116383169018 6.88553098788624e-13 -0.993075734580867 1.37876508579496e-06 mirMAP -0.239450639911665 5.21180596069304e-08 NA NA NA hsa-miR-107 PIK3R5 0.658676029898313 5.11480446318819e-07 -1.41857329052665 4.9150449517908e-09 miRanda -0.303365993068523 0.000471196296141979 NA NA NA hsa-miR-182-5p PIK3R5 3.21839823004635 5.13049145201115e-39 -1.41857329052665 4.9150449517908e-09 MirTarget -0.327566926397612 1.58877421029473e-15 NA NA NA hsa-miR-142-5p PLA2G12A 1.29672439149353 4.0768822158894e-06 -0.0788546181881973 0.499158564786441 mirMAP -0.131800396566356 4.84970998647658e-11 NA NA NA hsa-miR-150-5p PLA2G12A -0.702328520623782 0.0215316651134431 -0.0788546181881973 0.499158564786441 mirMAP -0.109476263552952 1.80094060108042e-10 NA NA NA hsa-miR-28-5p PLA2G1B 1.19639196514745 4.59365801666536e-18 -4.65869434494303 5.92632211074147e-12 miRanda -0.714163430019852 0.00154176723606543 NA NA NA hsa-miR-361-5p PLA2G2A 0.21454431962475 0.0800957579368424 -2.28008503185378 0.000145863257153751 miRanda -0.555826622229242 0.0165493751978908 NA NA NA hsa-miR-432-5p PLA2G2D -0.308818761349565 0.414172181069431 1.2831755733228 0.0119582527429079 mirMAP -0.137690274984799 0.031939757857889 NA NA NA hsa-miR-1976 PLA2G2F -1.27772236648866 7.13245221784788e-10 1.85239250918301 0.000408421370733288 mirMAP -0.412433519219505 0.000339748244121928 NA NA NA hsa-miR-324-3p PLA2G2F -0.0774700133118458 0.689226297032231 1.85239250918301 0.000408421370733288 mirMAP -0.305242523385136 0.0156797886273138 NA NA NA hsa-miR-484 PLA2G2F -0.228576985124486 0.244112867390855 1.85239250918301 0.000408421370733288 mirMAP -0.246120463510952 0.048456880319733 NA NA NA hsa-miR-532-3p PLA2G2F -0.677758187385834 0.0147557885796065 1.85239250918301 0.000408421370733288 mirMAP -0.180902222675426 0.0384991747781256 NA NA NA hsa-miR-532-5p PLA2G2F 0.576620898517708 0.0023245812680956 1.85239250918301 0.000408421370733288 mirMAP -0.384692781015398 0.00274632142999211 NA NA NA hsa-miR-450b-5p PLA2G3 1.69248953402469 1.96052058003353e-07 -3.26398420302921 7.81993892455061e-08 miRNATAP -0.430421579056939 6.90748646882128e-06 NA NA NA hsa-miR-452-3p PLA2G3 0.477736876273128 0.22218404598603 -3.26398420302921 7.81993892455061e-08 MirTarget -0.255221077598253 0.00248457917549569 NA NA NA hsa-miR-139-5p PLA2G4A -2.26625553116965 7.22375119369519e-16 1.23139708452911 0.00360064815222154 miRanda -0.164857799399304 0.0145088617499985 NA NA NA hsa-miR-146b-5p PLA2G4A 1.0922867893808 5.63754607494775e-06 1.23139708452911 0.00360064815222154 miRNAWalker2_validate -0.539646016767087 8.49384554342977e-12 NA NA NA hsa-miR-30a-5p PLA2G4A -0.924084264430689 0.000762030454634728 1.23139708452911 0.00360064815222154 miRNAWalker2_validate -0.337988397444713 1.56392399647892e-06 NA NA NA hsa-miR-361-5p PLA2G4A 0.21454431962475 0.0800957579368424 1.23139708452911 0.00360064815222154 miRanda -0.455000317938252 0.005160776853399 NA NA NA hsa-miR-362-3p PLA2G4A 0.194097672030785 0.52808475179225 1.23139708452911 0.00360064815222154 miRanda -0.171453837499879 0.0315287026338848 NA NA NA hsa-miR-374a-5p PLA2G4A -0.197027254874826 0.298080902192861 1.23139708452911 0.00360064815222154 mirMAP -0.384602231876405 0.000945916552995376 NA NA NA hsa-miR-450b-5p PLA2G4E 1.69248953402469 1.96052058003353e-07 -0.723776164951995 0.201279307414008 mirMAP -0.353591315163214 6.01448410118293e-05 NA NA NA hsa-miR-128-3p PLA2G5 1.03509868349735 2.11606310588315e-10 -1.52854910719925 3.60899705613865e-08 miRNAWalker2_validate -0.463850459902729 2.23760548419397e-09 NA NA NA hsa-miR-330-5p PLA2G5 0.168520831101569 0.336433937906706 -1.52854910719925 3.60899705613865e-08 miRanda -0.308708237234084 3.20106460280176e-05 NA NA NA hsa-miR-361-5p PLA2G5 0.21454431962475 0.0800957579368424 -1.52854910719925 3.60899705613865e-08 miRanda -0.251832084398457 0.0197645868459458 NA NA NA hsa-miR-429 PLA2G5 2.3794516574089 1.72813419703734e-13 -1.52854910719925 3.60899705613865e-08 miRanda -0.178077576146297 2.39509849764538e-05 NA NA NA hsa-miR-590-5p PLA2G5 2.07441240363458 4.95240551694843e-14 -1.52854910719925 3.60899705613865e-08 miRanda -0.21637478398772 0.000135984222229852 NA NA NA hsa-miR-185-3p PLA2G6 -0.377490365509078 0.093653288903368 0.476315859876846 0.0705352394789323 MirTarget -0.267493284551792 5.88524200603373e-07 NA NA NA hsa-miR-30a-3p PLA2G6 -2.54042202792785 2.9111625410859e-18 0.476315859876846 0.0705352394789323 miRNATAP -0.146668786631899 0.000240180915888741 NA NA NA hsa-miR-423-5p PLA2G6 -1.80309342242719 1.34791344187441e-19 0.476315859876846 0.0705352394789323 MirTarget;miRNATAP -0.232289362179402 7.11654533343099e-05 NA NA NA hsa-let-7a-3p PM20D2 0.167285443861993 0.431834813181487 0.606459006986973 0.000338690654672399 MirTarget -0.143921577075165 0.000492400787257315 NA NA NA hsa-let-7a-3p POU6F2 0.167285443861993 0.431834813181487 2.07266400827315 0.00225592092921382 mirMAP -0.386191050231397 0.0201888585304837 NA NA NA hsa-let-7a-3p PPP1CC 0.167285443861993 0.431834813181487 0.14862984928136 0.172735526583351 mirMAP -0.130460425813307 6.27478070572965e-07 NA NA NA hsa-let-7a-3p PPP1R12A 0.167285443861993 0.431834813181487 -0.103105147098241 0.372850863217555 mirMAP;miRNATAP -0.106928198882935 0.000129911167400404 NA NA NA hsa-miR-106a-5p PPP3CA 1.3902608059488 6.07931522284525e-05 -0.313973239016408 0.0165177462343014 miRNATAP -0.133933104567234 1.19345709173472e-12 NA NA NA hsa-miR-142-3p PPP3CA 3.98476449801341 1.56256182021111e-35 -0.313973239016408 0.0165177462343014 miRNATAP -0.118826172048727 2.75854825586705e-12 NA NA NA hsa-miR-17-5p PPP3CA 2.07078488653279 2.77403038572568e-19 -0.313973239016408 0.0165177462343014 miRNATAP -0.176015588845375 7.62312188608765e-13 NA NA NA hsa-miR-186-5p PPP3CA 0.852175445703945 6.88885738584309e-10 -0.313973239016408 0.0165177462343014 mirMAP -0.286847992743368 1.57472937315132e-11 NA NA NA hsa-miR-20a-5p PPP3CA 2.64649625616975 5.1469418982085e-27 -0.313973239016408 0.0165177462343014 miRNATAP -0.154552998486965 9.11892644521842e-12 NA NA NA hsa-miR-20b-5p PPP3CA 1.35770573270947 0.00260808530013016 -0.313973239016408 0.0165177462343014 miRNATAP -0.122294666346707 1.15249428256532e-19 NA NA NA hsa-miR-30c-5p PPP3CA -0.327319105755825 0.123595832152687 -0.313973239016408 0.0165177462343014 miRNATAP -0.10873673306536 0.000125286600086868 NA NA NA hsa-miR-361-3p PPP3CA 0.0988926195529967 0.549128728500555 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.173641727258806 2.07130127414673e-06 NA NA NA hsa-miR-501-3p PPP3CA -0.0405952693028064 0.866802243505833 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.152231773192009 5.82453493976863e-10 NA NA NA hsa-miR-502-3p PPP3CA -0.262270070977708 0.161760375279961 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.102225645893012 0.00155670003675052 NA NA NA hsa-miR-589-3p PPP3CA 1.34253876396688 1.84935927493927e-05 -0.313973239016408 0.0165177462343014 MirTarget -0.111512777165905 9.25189699847489e-09 NA NA NA hsa-miR-590-3p PPP3CA 0.83851360565783 0.00129224433453587 -0.313973239016408 0.0165177462343014 miRanda;mirMAP -0.108711400054004 7.97592745451833e-05 NA NA NA hsa-miR-590-5p PPP3CA 2.07441240363458 4.95240551694843e-14 -0.313973239016408 0.0165177462343014 PITA;miRanda;miRNATAP -0.177690930412641 6.75602594094779e-12 NA NA NA hsa-miR-7-1-3p PPP3CA 2.61364240402652 1.98959237815786e-32 -0.313973239016408 0.0165177462343014 MirTarget;mirMAP -0.121059394653456 5.88147588879243e-06 NA NA NA hsa-miR-93-3p PPP3CA 1.07631808403007 1.63747525692813e-05 -0.313973239016408 0.0165177462343014 miRNATAP -0.170128744194282 3.50156314525736e-13 NA NA NA hsa-miR-93-5p PPP3CA 1.50844106515467 1.83836866996875e-12 -0.313973239016408 0.0165177462343014 miRNATAP -0.25180151434334 1.28858993768457e-21 NA NA NA hsa-miR-15a-5p PPP3CB 1.62575353599172 1.55312121019827e-19 -0.217161149975175 0.026537796620393 miRNATAP -0.123109224513088 2.45320870406106e-07 NA NA NA hsa-miR-30c-5p PPP3CB -0.327319105755825 0.123595832152687 -0.217161149975175 0.026537796620393 miRNATAP -0.117562918064524 1.93721091880072e-08 NA NA NA hsa-miR-361-5p PPP3CB 0.21454431962475 0.0800957579368424 -0.217161149975175 0.026537796620393 miRanda -0.127974103120468 0.000592380004256261 NA NA NA hsa-miR-361-5p PPP3CC 0.21454431962475 0.0800957579368424 -0.864879436917075 5.11810186256782e-12 miRanda -0.162282770575647 0.000912467378574366 NA NA NA hsa-miR-181a-5p PPP3R1 -0.375429731222937 0.0562142867129802 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.174665544764319 9.40491398689482e-15 NA NA NA hsa-miR-181b-5p PPP3R1 0.668793269169928 0.000239998092406404 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.114349020464675 3.84750784901666e-06 NA NA NA hsa-miR-181c-5p PPP3R1 0.529875814537156 0.0125885822998008 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.106737924157465 4.8061231789594e-07 NA NA NA hsa-miR-27b-3p PPP3R1 0.236438984240408 0.12263510345883 -0.021451907795778 0.828812244123992 miRNATAP -0.122284709618602 4.10399666262129e-05 NA NA NA hsa-miR-30b-5p PPP3R1 0.358144314839612 0.138026229059594 -0.021451907795778 0.828812244123992 MirTarget -0.109418887183495 3.74739901258502e-09 NA NA NA hsa-miR-30c-5p PPP3R1 -0.327319105755825 0.123595832152687 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.157231202749467 5.03548982239333e-14 NA NA NA hsa-miR-342-3p PPP3R1 -0.128691966564961 0.561034080130801 -0.021451907795778 0.828812244123992 MirTarget;miRanda;miRNATAP -0.120856614371424 2.53668736670026e-09 NA NA NA hsa-miR-34a-5p PPP3R1 1.40588612517769 8.60097477768592e-12 -0.021451907795778 0.828812244123992 miRNAWalker2_validate -0.170360603226023 4.36468130338985e-16 NA NA NA hsa-let-7a-3p PRKACB 0.167285443861993 0.431834813181487 -0.337490057919314 0.0956151593593903 MirTarget;mirMAP;miRNATAP -0.109621340434496 0.0264314696722877 NA NA NA hsa-let-7a-3p PRKAR2A 0.167285443861993 0.431834813181487 -0.542111912815549 0.00820991566022701 mirMAP -0.129600545591328 0.00965385633423682 NA NA NA hsa-miR-17-3p PRKCA 1.36706429551147 4.60388403547821e-13 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.2211557176846 0.000413342702730225 NA NA NA hsa-miR-181c-5p PRKCA 0.529875814537156 0.0125885822998008 -0.189679589892687 0.471078192212991 mirMAP -0.326745565499583 6.66432412436314e-09 NA NA NA hsa-miR-183-5p PRKCA 2.39247234736657 3.92444525331999e-21 -0.189679589892687 0.471078192212991 miRNATAP -0.191021307259656 2.63755654536705e-05 NA NA NA hsa-miR-186-5p PRKCA 0.852175445703945 6.88885738584309e-10 -0.189679589892687 0.471078192212991 miRNATAP -0.182809848844304 0.0364827269657349 NA NA NA hsa-miR-193b-3p PRKCA 1.10444771306846 0.000822888533401377 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.138487066621768 0.000138664149309437 NA NA NA hsa-miR-193b-5p PRKCA 0.179695858885499 0.55521472494233 -0.189679589892687 0.471078192212991 mirMAP -0.137899397693864 0.000521039895191079 NA NA NA hsa-miR-19b-1-5p PRKCA 1.71217036351784 3.28561659177495e-12 -0.189679589892687 0.471078192212991 mirMAP -0.210975845049586 0.000143708055393517 NA NA NA hsa-miR-200b-3p PRKCA 1.55157578247391 4.83790020897188e-09 -0.189679589892687 0.471078192212991 TargetScan -0.1088658423995 0.0155570891072353 NA NA NA hsa-miR-200c-3p PRKCA 0.380533388300368 0.0842181838538353 -0.189679589892687 0.471078192212991 miRNATAP -0.262911308228053 1.5097135867061e-06 NA NA NA hsa-miR-22-5p PRKCA 1.71436244278242 9.85038001236064e-15 -0.189679589892687 0.471078192212991 mirMAP -0.177526746625668 0.000829577475678236 NA NA NA hsa-miR-24-2-5p PRKCA 1.43704663046967 4.34375016509278e-11 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.114268570782096 0.0364691635457816 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-429 PRKCA 2.3794516574089 1.72813419703734e-13 -0.189679589892687 0.471078192212991 miRanda;miRNATAP -0.142853746691809 0.000293353456114152 NA NA NA hsa-miR-590-3p PRKCA 0.83851360565783 0.00129224433453587 -0.189679589892687 0.471078192212991 PITA;miRanda;mirMAP;miRNATAP -0.19448195031258 0.000455368438666445 NA NA NA hsa-miR-92a-3p PRKCA -0.136362762339122 0.493412263619364 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.160805726714066 0.00861285946041943 NA NA NA hsa-miR-93-3p PRKCA 1.07631808403007 1.63747525692813e-05 -0.189679589892687 0.471078192212991 mirMAP -0.159060267220526 0.000935006714973491 NA NA NA hsa-miR-141-5p PRKCB 3.02575703771074 1.54385222591327e-32 -1.01521651364956 0.000234705382361064 mirMAP -0.19965194499171 1.76112086865619e-05 NA NA NA hsa-miR-200b-3p PRKCB 1.55157578247391 4.83790020897188e-09 -1.01521651364956 0.000234705382361064 MirTarget -0.139521777238666 0.00328113460432514 NA NA NA hsa-miR-200c-3p PRKCB 0.380533388300368 0.0842181838538353 -1.01521651364956 0.000234705382361064 MirTarget;miRNATAP -0.217004467533231 0.000183295321414174 NA NA NA hsa-miR-24-3p PRKCB -0.0357874587555003 0.785865078836504 -1.01521651364956 0.000234705382361064 miRNATAP -0.200930519007703 0.0424759197567277 NA NA NA hsa-miR-335-3p PRKCB 1.51116383169018 6.88553098788624e-13 -1.01521651364956 0.000234705382361064 mirMAP -0.246405652657792 3.09182980578855e-05 NA NA NA hsa-miR-429 PRKCB 2.3794516574089 1.72813419703734e-13 -1.01521651364956 0.000234705382361064 MirTarget;miRanda;miRNATAP -0.166472060253132 6.28432741975052e-05 NA NA NA hsa-miR-450b-5p PRKCB 1.69248953402469 1.96052058003353e-07 -1.01521651364956 0.000234705382361064 miRNATAP -0.183354145967975 2.13964194654069e-05 NA NA NA hsa-miR-589-3p PRKCB 1.34253876396688 1.84935927493927e-05 -1.01521651364956 0.000234705382361064 mirMAP -0.153872579100374 0.000218865142512993 NA NA NA hsa-miR-589-5p PRKCB 0.233778899379261 0.228477190986199 -1.01521651364956 0.000234705382361064 mirMAP -0.191889757915074 0.00377217964937973 NA NA NA hsa-miR-590-5p PRKCB 2.07441240363458 4.95240551694843e-14 -1.01521651364956 0.000234705382361064 miRanda -0.247831270781318 8.78932489501914e-06 NA NA NA hsa-miR-7-1-3p PRKCB 2.61364240402652 1.98959237815786e-32 -1.01521651364956 0.000234705382361064 mirMAP -0.119995650641294 0.0359252672231447 NA NA NA hsa-miR-2110 PRKCG -1.92124860612475 1.1464887721828e-12 1.66883505426905 0.000268885102920086 MirTarget -0.307845409938279 6.49952836801256e-05 NA NA NA hsa-miR-326 PRKCG -0.992397386750901 0.00335173765975096 1.66883505426905 0.000268885102920086 miRanda -0.268960075781158 1.49724165244188e-05 NA NA NA hsa-miR-335-5p PRKCG -0.466533891325811 0.0676987038122831 1.66883505426905 0.000268885102920086 miRNAWalker2_validate -0.28334410784476 0.00233636911178136 NA NA NA hsa-miR-101-3p PTGS2 1.38889039459232 1.96522549511542e-09 -1.03369714758802 0.032296876715107 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.249551004902669 0.00850927718081984 24958470;26530100;21430074;24759835;26556718;24289600;23644120;26617722;19133256;24528073;25109742;23013439 Interestingly cyclooxygenase-2 inhibition by aspirin or celecoxib abrogated IL-1β-mediated repression of miR-101 and IL-1β-mediated activation of Lin28B along with their stimulatory effects on NSCLC cell proliferation and migration;Luciferase assay revealed that COX-2 was a direct target for miR-101-3p and overexpression of miR-101-3p decreased cellular COX-2 protein expression; Finally downregulation of miR-101-3p expression and upregulation of COX-2 was found in ESCC specimens from patients with smoking history; Taken together our findings revealed a new post-transcriptional mechanism by which CSE regulated COX-2 expression to favor cancer cell proliferation suggesting miR-101-3p as a potential biomarker and therapeutic target for smoke-related ESCC;Enforced expression of miR 101 inhibits prostate cancer cell growth by modulating the COX 2 pathway in vivo; In this study we investigated the mechanism of microRNA-101 miR-101-regulated COX-2 expression and the therapeutic potential of exogenous miR-101 for COX-2-associated cancer; We found that miR-101 inhibited COX-2 posttranscriptional expression by directly binding to the 3'-untranslated region 3'-UTR of COX-2 mRNA; In conclusion COX-2 is a direct target in miR-101 regulation of posttranscription; These data suggest that exogenous miR-101 may provide a new cancer therapy by directly inhibiting COX-2 expression;MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels;Cyclooxygenase 2 a Potential Therapeutic Target Is Regulated by miR 101 in Esophageal Squamous Cell Carcinoma; This study investigated the effect of miR-101 on ESCC through modulating COX-2 expression in ESCC; The luciferase reporter assay was used to verify COX-2 as a direct target of miR-101; Furthermore COX-2 was shown to be a target of miR-101;The expression of COX-2 in Hela cell was also examined by immunohistochemical staining and the correlation with miR-101 expression was analysed; Thus reduced miR-101 expression could participate in the development of cervical cancer at least partly through loss of inhibition of target gene COX-2 which probably occurs in a relative late phase of carcinogenesis;Expressions of COX 2 PKC α and miR 101 in gastric cancer and their correlations; To investigate the expressions of miR-101 protein kinase C-α PKC-α and cyclooxygenase-2 COX-2 in gastric cancer GC tissue and their correlations; RT-qPCR was used to examine miR-101 expression and Western blotting employed to detect PKC-α and COX-2 expressions in 57 cases of gastric cancer tissues and paired normal gastric mucosal tissues; The gastric cancer tissues showed a significantly lower miR-101 expression Z=6.102 P<0.05 but significantly higher expressions of COX-2 Z=14.436 P<0.05 and PKC-α Z=6.955 P<0.05 than the normal gastric tissues; PKC-α expression was positively correlated r=0.531 P<0.05 and miR-101 expression negatively correlated r=-0.627 P<0.05 with COX-2 expression in gastric cancer tissues; miR-101 PKC-α and COX-2 all play a role in the tumorigenesis and progression of gastric cancer; miR-101 and PKC-α might be new potential therapeutic targets for inhibiting COX-2 in gastric cancer;Immunohistochemistry was performed to assess protein expression of the miR-101 target gene COX-2; Overexpression of miR-101 decreased expression of its target gene Cox-2 and inhibited proliferation and invasion and promoted apoptosis to suppress tumorigenicity;MiR 101 downregulation is involved in cyclooxygenase 2 overexpression in human colon cancer cells; In this paper we report the inverse correlation between COX-2 and miR-101 expression in colon cancer cell lines and we demonstrated in vitro the direct inhibition of COX-2 mRNA translation mediated by miR-101; These findings provide a novel molecular insight in the modulation of COX-2 at post-transcriptional level by miR-101 and strengthen the observation that miRNAs are highly implicated in the control of gene expression; An impairment of miR-101 levels could represent one of the leading causes of COX-2 overexpression in colon cancer cells;Roles of MiR 101 and its target gene Cox 2 in early diagnosis of cervical cancer in Uygur women; Use of down-regulation of miR-101 and up-regulation of Cox-2 as markers may play a role in early diagnosis of cervical cancer in Uygur women;Enforced expression of miR 101 enhances cisplatin sensitivity in human bladder cancer cells by modulating the cyclooxygenase 2 pathway;Downregulation of miR 101 in gastric cancer correlates with cyclooxygenase 2 overexpression and tumor growth; Here we characterize miR-101 expression and its role in the regulation of COX-2 expression which in turn will provide us with additional insights into the potential therapeutic benefits of exogenous miR-101 for treatment of gastric cancer; We also found an inverse correlation between miR-101 and COX-2 expression in both gastric cancer specimens and cell lines; One possible mechanism of interaction is that miR-101 inhibited COX-2 expression by directly binding to the 3'-UTR of COX-2 mRNA; These results collectively indicate that miR-101 may function as a tumor suppressor in gastric cancer with COX-2 as a direct target ;;;;;tumorigenesis;progression;tumorigenesis;;;;; lung cancer;esophageal cancer;prostate cancer;liver cancer;esophageal cancer;cervical and endocervical cancer;gastric cancer;cervical and endocervical cancer;colon cancer;cervical and endocervical cancer;bladder cancer;gastric cancer hsa-miR-146b-5p PTGS2 1.0922867893808 5.63754607494775e-06 -1.03369714758802 0.032296876715107 miRanda -0.370951337285379 5.00511906316448e-05 NA NA NA hsa-miR-16-2-3p PTGS2 0.503964803530872 0.0263648405197492 -1.03369714758802 0.032296876715107 mirMAP -0.334544410725452 0.00170989664243796 NA NA NA hsa-miR-16-5p PTGS2 0.749619098384047 4.11649450706988e-06 -1.03369714758802 0.032296876715107 miRNAWalker2_validate;miRTarBase -0.557741889577594 4.18248826425404e-05 24759835;25196524 MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels;Artesunate induces apoptosis of bladder cancer cells by miR 16 regulation of COX 2 expression; Cyclooxygenase-2 COX-2 and miR-16 expression levels were determined with real-time PCR; ART efficiently inhibited orthotopic tumor growth in the bladder cancer rat which is accompanied with an increase of miR-16 expression and a decrease of COX-2 expression; ART significantly increased miR-16 expression and decreased the expression of COX-2 and the production of PGE2; More importantly down-regulation of miR-16 expression could reverse the effect of ART on apoptosis and COX-2 expression in bladder cells; In conclusion ART can elicit an anti-tumor effect against bladder cancer by up-regulation of miR-16 expression which resulted in the decrease of COX-2 expression and PGE2 production ; liver cancer;bladder cancer hsa-miR-17-5p PTGS2 2.07078488653279 2.77403038572568e-19 -1.03369714758802 0.032296876715107 miRNAWalker2_validate -0.263976599489779 0.004496619277825 NA NA NA hsa-miR-29b-1-5p PTGS2 1.71024742617744 3.64915691793611e-09 -1.03369714758802 0.032296876715107 MirTarget -0.296673951688718 8.05914160567646e-05 NA NA NA hsa-miR-362-3p PTGS2 0.194097672030785 0.52808475179225 -1.03369714758802 0.032296876715107 miRanda -0.247201801855878 0.00642369816175574 NA NA NA hsa-miR-576-5p PTGS2 1.02693643167056 1.14846964470173e-06 -1.03369714758802 0.032296876715107 mirMAP -0.248407065451667 0.0178575013529413 NA NA NA hsa-miR-7-1-3p PTGS2 2.61364240402652 1.98959237815786e-32 -1.03369714758802 0.032296876715107 MirTarget -0.32165354375189 0.00120377123008504 NA NA NA hsa-miR-140-5p PTK2 0.669142684153918 0.000335928403032308 0.278007300053823 0.026596373778384 miRanda -0.161505490487641 2.71491649672642e-07 NA NA NA hsa-miR-186-5p PXN 0.852175445703945 6.88885738584309e-10 -0.370846857620499 0.00947181315964173 mirMAP -0.113443698338529 0.016893332472953 NA NA NA hsa-miR-335-5p PXN -0.466533891325811 0.0676987038122831 -0.370846857620499 0.00947181315964173 miRNAWalker2_validate -0.100714810055646 0.000474599225786488 NA NA NA hsa-let-7a-3p RAB10 0.167285443861993 0.431834813181487 0.362135118214509 0.00294587876571628 MirTarget;miRNATAP -0.135793677276773 4.017216564732e-06 NA NA NA hsa-let-7a-3p RAB2A 0.167285443861993 0.431834813181487 0.32877195343921 0.00781376165933009 miRNATAP -0.103682583804781 0.000551278196988847 NA NA NA hsa-let-7a-3p RAB8B 0.167285443861993 0.431834813181487 -1.14932427791855 6.42814390619252e-12 mirMAP -0.131054798066383 0.00164226805014214 NA NA NA hsa-miR-30c-5p RAC1 -0.327319105755825 0.123595832152687 0.217355195910818 0.0528286499053578 miRNAWalker2_validate -0.11419324793125 2.23761362474291e-06 NA NA NA hsa-miR-193b-3p RAC2 1.10444771306846 0.000822888533401377 -0.656275624483639 0.00297441142612925 miRNAWalker2_validate -0.112838589622127 0.000231783502607722 NA NA NA hsa-miR-125a-5p RAC3 -1.04824536696301 3.97386082850476e-07 1.82835649257478 3.33704760151114e-09 PITA -0.183541043002533 0.00831332585841968 NA NA NA hsa-miR-30c-2-3p RAC3 -3.10905250533941 6.84550165664783e-27 1.82835649257478 3.33704760151114e-09 miRNAWalker2_validate -0.370936437115312 5.24524075378395e-16 NA NA NA hsa-let-7a-3p RAD21 0.167285443861993 0.431834813181487 0.11334978665193 0.429901957673873 miRNATAP -0.136325916901246 8.63934555597985e-05 NA NA NA hsa-let-7a-3p RALGPS2 0.167285443861993 0.431834813181487 1.68764274962317 1.26598383317838e-14 mirMAP -0.127266375376928 0.0206845258614126 NA NA NA hsa-let-7a-3p RFC3 0.167285443861993 0.431834813181487 0.682656342814036 0.000222388874525933 MirTarget -0.128163322482918 0.00462905712192459 NA NA NA hsa-let-7a-3p RHOBTB3 0.167285443861993 0.431834813181487 0.184868592490703 0.436525291977275 MirTarget -0.130179132734979 0.0245356982501076 NA NA NA hsa-let-7a-3p RHPN2 0.167285443861993 0.431834813181487 0.912000571301705 0.000298466416661006 MirTarget -0.122728620699026 0.0473959675261493 NA NA NA hsa-let-7a-3p RNF2 0.167285443861993 0.431834813181487 0.355850954316877 0.00384436868778128 MirTarget;miRNATAP -0.118122266918005 7.59960108472832e-05 NA NA NA hsa-let-7a-3p RNF34 0.167285443861993 0.431834813181487 0.565612725129197 1.4562998110668e-08 miRNATAP -0.104435674212709 1.90646576226711e-05 NA NA NA hsa-let-7a-3p ROCK2 0.167285443861993 0.431834813181487 -0.472681855522957 0.0066083763551485 mirMAP -0.150130294559708 0.000392125465187804 NA NA NA hsa-let-7a-3p RSPO3 0.167285443861993 0.431834813181487 -1.66375652226303 0.000140095171166556 MirTarget -0.252135751978842 0.0187929703012753 NA NA NA hsa-let-7a-3p SBNO1 0.167285443861993 0.431834813181487 0.218633910021256 0.259585297783949 mirMAP;miRNATAP -0.1413928312664 0.00270637386018674 NA NA NA hsa-let-7a-3p SEC24A 0.167285443861993 0.431834813181487 0.557629276958948 2.49723361362507e-05 mirMAP -0.107303248805888 0.000907974181620732 NA NA NA hsa-let-7a-3p SGMS1 0.167285443861993 0.431834813181487 -0.837258104086347 4.7657367833826e-06 mirMAP -0.161717892685439 0.000311390777920221 NA NA NA hsa-let-7a-3p SGTB 0.167285443861993 0.431834813181487 -0.513396461625332 0.000335588604276451 MirTarget;miRNATAP -0.113284823419941 0.00118467504774509 NA NA NA hsa-miR-107 SH2D2A 0.658676029898313 5.11480446318819e-07 0.705747976791678 0.00284133613351839 PITA;miRanda;miRNATAP -0.190907279856789 0.0227026909788836 NA NA NA hsa-let-7a-3p SLC25A40 0.167285443861993 0.431834813181487 0.0626958299803557 0.707293728529791 mirMAP -0.134850990951679 0.000867792487727298 NA NA NA hsa-let-7a-3p SLC36A4 0.167285443861993 0.431834813181487 0.491666525600721 0.00273673816518247 mirMAP -0.122662099550868 0.00217798769992371 NA NA NA hsa-let-7a-3p SNAI1 0.167285443861993 0.431834813181487 -0.758705608706721 0.00279194957161285 miRNATAP -0.145599632531001 0.0190522679654119 NA NA NA hsa-let-7a-3p SNX10 0.167285443861993 0.431834813181487 -0.988133664774077 4.56631819183822e-05 mirMAP -0.188850146397767 0.00147806183057573 NA NA NA hsa-let-7a-3p SNX9 0.167285443861993 0.431834813181487 0.422939918015033 0.00145778872723561 miRNATAP -0.111325241237171 0.000576718827708842 NA NA NA hsa-miR-330-3p SPHK1 -0.716924999893351 0.000796236278616087 0.49292057318817 0.0966832552880382 miRNATAP -0.269842391482062 2.17580041220939e-05 NA NA NA hsa-let-7a-3p SPIN4 0.167285443861993 0.431834813181487 0.00324031477103803 0.986924733244146 mirMAP -0.118782039160161 0.0135486484233413 NA NA NA hsa-miR-195-5p SRC -1.01577502605386 4.80814718341729e-05 0.536847781930278 0.000183762865185033 mirMAP -0.129046385477166 3.02317610630897e-06 NA NA NA hsa-miR-23b-3p SRC -0.070273068040148 0.620585267977425 0.536847781930278 0.000183762865185033 miRNAWalker2_validate;miRTarBase -0.116913413083586 0.0138358920406806 23074286 miR 23b represses proto oncogene Src kinase and functions as methylation silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer; We showed that proto-oncogene Src kinase and Akt are direct targets of miR-23b; Depletion of Src by RNA interference conferred similar functional effects as that of miR-23b reconstitution; miR-23b expression caused a dramatic decrease in tumor growth in nude mice and attenuated Src expression in excised tumors compared with a control miR prostate cancer hsa-let-7a-3p ST6GALNAC3 0.167285443861993 0.431834813181487 -2.43293280236253 1.40047601719427e-18 MirTarget -0.154919661907805 0.0273139677341305 NA NA NA hsa-let-7a-3p STRN 0.167285443861993 0.431834813181487 -0.164891555136723 0.384170238544358 mirMAP -0.181832235353114 7.39146761186689e-05 NA NA NA hsa-let-7a-3p TAOK1 0.167285443861993 0.431834813181487 -0.16111893285224 0.476174522942365 MirTarget;miRNATAP -0.172505134448491 0.00169358772658159 NA NA NA hsa-let-7a-3p TBC1D15 0.167285443861993 0.431834813181487 -0.572329355358976 1.55437844376555e-07 MirTarget;miRNATAP -0.102759222404931 0.000119503146075501 NA NA NA hsa-let-7a-3p TFAM 0.167285443861993 0.431834813181487 0.496621274402393 0.000268363379974617 MirTarget;mirMAP -0.148229881307684 7.45812104616909e-06 NA NA NA hsa-let-7a-3p TFRC 0.167285443861993 0.431834813181487 -1.37913041397881 2.7890199223269e-09 mirMAP -0.178988696960668 0.00183395761995906 NA NA NA hsa-let-7a-3p TMEM39A 0.167285443861993 0.431834813181487 0.293739384076424 0.00835139169057567 MirTarget;miRNATAP -0.116283313417496 1.56136273910713e-05 NA NA NA hsa-let-7a-3p TMEM55A 0.167285443861993 0.431834813181487 -0.503628696569831 0.00898301129241822 mirMAP -0.168247834358465 0.000333951889546472 NA NA NA hsa-let-7a-3p TMPO 0.167285443861993 0.431834813181487 0.532942774452054 0.00156916850278323 mirMAP -0.195740256094232 1.64389525911442e-06 NA NA NA hsa-let-7a-3p TMTC3 0.167285443861993 0.431834813181487 0.197015311797843 0.186747920068746 MirTarget -0.100173217841923 0.00574162462101043 NA NA NA hsa-let-7a-3p TRERF1 0.167285443861993 0.431834813181487 0.443157801747605 0.0354034216866223 mirMAP -0.169982032112618 0.000911441904078891 NA NA NA hsa-let-7a-3p TSC22D2 0.167285443861993 0.431834813181487 -0.385352448019764 0.0338308658155365 MirTarget;mirMAP -0.167678577338109 0.000142355990068699 NA NA NA hsa-let-7a-3p TTC5 0.167285443861993 0.431834813181487 -0.149351511179806 0.310661172054653 mirMAP -0.117874813710414 0.000967823908044963 NA NA NA hsa-let-7a-3p UBE2Q2 0.167285443861993 0.431834813181487 -0.204688715393801 0.0986193830091935 MirTarget -0.113461140058703 0.000154592661968231 NA NA NA hsa-let-7a-3p UBE2W 0.167285443861993 0.431834813181487 0.513074501369291 0.000616672056054498 MirTarget;mirMAP;miRNATAP -0.135865674497593 0.000196550129060691 NA NA NA hsa-let-7a-3p UGT3A1 0.167285443861993 0.431834813181487 -0.106622400285718 0.873910802051634 mirMAP -0.466097441105536 0.00437564248495095 NA NA NA hsa-let-7a-3p UHMK1 0.167285443861993 0.431834813181487 0.246502029645703 0.319695031714029 MirTarget;mirMAP -0.19517688177375 0.00118660903122075 NA NA NA hsa-let-7a-3p USP12 0.167285443861993 0.431834813181487 -1.07278863643269 1.83904836973154e-10 MirTarget;mirMAP;miRNATAP -0.121544393322346 0.00361191119034114 NA NA NA hsa-let-7a-3p USP37 0.167285443861993 0.431834813181487 0.568351798122 2.82800676141737e-06 mirMAP -0.110210916449286 0.000203844798767916 NA NA NA hsa-let-7a-3p VCAN 0.167285443861993 0.431834813181487 0.994352879288806 0.00135386599775065 MirTarget -0.151355656196048 0.0466641255508289 NA NA NA hsa-miR-1-3p VEGFA -1.48412019995919 0.000242034342580425 0.230749341603949 0.311300638391058 MirTarget -0.172921089301484 3.76698090411866e-10 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-101-3p VEGFA 1.38889039459232 1.96522549511542e-09 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.184546125824104 3.21659312920503e-05 NA NA NA hsa-miR-125a-3p VEGFA -1.04954492275266 2.45974219476832e-06 0.230749341603949 0.311300638391058 miRanda -0.155505773345232 0.000854677712414177 22768249 Ectopic expression of MiR 125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF; Furthermore miR-125a expression was inversely correlated with both MMP11 and VEGF-A expression in HCC tissues; MiR-125a inhibits the proliferation and metastasis of HCC by targeting MMP11 and VEGF-A metastasis liver cancer hsa-miR-133a-3p VEGFA -2.89609207852024 1.71222048144972e-13 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.104720990536239 5.4001689907379e-05 NA NA NA hsa-miR-140-5p VEGFA 0.669142684153918 0.000335928403032308 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.246162039129829 1.79001025551982e-05 26402430 MicroRNA 140 5p inhibits the progression of colorectal cancer by targeting VEGFA; The direct regulation of VEGFA by miR-140-5p was identified using luciferase reporter assay; Integrated analysis identified VEGFA as a direct and functional target gene of miR-140-5p; Silencing VEGFA by small interfering RNA siRNA resembled the phenotype resulting from ectopic miR-140-5p expression while overexpression of VEGFA attenuated the effect of miR-140-5p on CRC cells; Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA progression;tumorigenesis colorectal cancer hsa-miR-150-5p VEGFA -0.702328520623782 0.0215316651134431 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase -0.211938415847961 3.12072029375035e-10 NA NA NA hsa-miR-15b-5p VEGFA -1.25935038177398 1.83460220856901e-12 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget -0.119640608007297 0.0381907284369183 22904162 TaqMan qRT-PCR was used to assess the expression of the selected miRNAs related to angiogenesis miR-15b -16 -17-5p -20a -21 -125a -200b -210 -214* -221 -222 and -424 and VEGF-A and TSP-1 mRNAs were assessed by qRT-PCR using SYBR Green endometrial cancer hsa-miR-195-5p VEGFA -1.01577502605386 4.80814718341729e-05 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget -0.216253591570711 7.05557590450539e-07 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-29c-3p VEGFA 1.32354490728858 1.84279305179762e-07 0.230749341603949 0.311300638391058 miRNAWalker2_validate;MirTarget -0.189793475587463 2.81724907347383e-06 NA NA NA hsa-miR-330-3p VEGFA -0.716924999893351 0.000796236278616087 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.385541553437526 4.9599607016426e-16 NA NA NA hsa-miR-335-5p VEGFA -0.466533891325811 0.0676987038122831 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.139733266743143 0.00237085343344445 NA NA NA hsa-miR-361-5p VEGFA 0.21454431962475 0.0800957579368424 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.311546652005902 0.000341919545726308 NA NA NA hsa-miR-374a-3p VEGFA 1.73882813668241 1.57901646296214e-13 0.230749341603949 0.311300638391058 MirTarget -0.116308302225143 0.0073756212717737 23679262 Our data demonstrated miR-374a to be differentially distributed in breast cancer; VEGF-A and VCAM-1 mRNA had coincident distribution and the distribution of teh respective proteins was uneven and opposite to that for the miR-374a breast cancer hsa-miR-374a-5p VEGFA -0.197027254874826 0.298080902192861 0.230749341603949 0.311300638391058 MirTarget -0.195164100931073 0.0017653451750918 23679262 Our data demonstrated miR-374a to be differentially distributed in breast cancer; VEGF-A and VCAM-1 mRNA had coincident distribution and the distribution of teh respective proteins was uneven and opposite to that for the miR-374a breast cancer hsa-miR-374b-5p VEGFA 0.474691035780475 0.0109217471394203 0.230749341603949 0.311300638391058 MirTarget -0.165654325982956 0.00541935782229369 NA NA NA hsa-miR-378a-3p VEGFA -2.0140903990983 1.146745431034e-18 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase -0.188122556602091 1.9053920640873e-05 NA NA NA hsa-let-7a-3p VIL1 0.167285443861993 0.431834813181487 4.78164597430505 1.17190114173403e-06 mirMAP -1.06725410957231 9.53457826394939e-06 NA NA NA hsa-let-7a-3p VPS37A 0.167285443861993 0.431834813181487 0.0591800761303363 0.7191088448956 MirTarget -0.128162660866881 0.00132504004465625 NA NA NA hsa-let-7a-3p WDHD1 0.167285443861993 0.431834813181487 1.55506430905992 1.15339355364856e-10 MirTarget -0.139570259178036 0.0201525362323183 NA NA NA hsa-let-7a-3p WDR43 0.167285443861993 0.431834813181487 0.457814071423766 0.000598581351097137 miRNATAP -0.124595935629176 0.000122829783525252 NA NA NA hsa-let-7a-3p XYLB 0.167285443861993 0.431834813181487 1.60730502820197 4.84322985172559e-14 MirTarget -0.17102184530017 0.00135392037917989 NA NA NA hsa-let-7a-3p YEATS4 0.167285443861993 0.431834813181487 0.409710628675915 0.022582058182064 MirTarget -0.177457601649135 4.65429998474761e-05 NA NA NA hsa-let-7a-3p YTHDF3 0.167285443861993 0.431834813181487 0.00406046338340893 0.971481042050944 MirTarget -0.112307679200326 4.10398778306876e-05 NA NA NA hsa-let-7a-3p ZBTB10 0.167285443861993 0.431834813181487 0.258184789173525 0.236912117088801 mirMAP -0.183931904868309 0.000519870374608022 NA NA NA hsa-let-7a-3p ZDHHC20 0.167285443861993 0.431834813181487 -0.517322986340565 0.0276425681279285 MirTarget -0.253673684615668 8.29902444913551e-06 NA NA NA hsa-let-7a-3p ZNF28 0.167285443861993 0.431834813181487 0.407505604594659 0.0111534287277993 mirMAP -0.104744023165505 0.00745911352731701 NA NA NA hsa-let-7a-3p ZNF518B 0.167285443861993 0.431834813181487 0.129535625213679 0.584405416856703 MirTarget;miRNATAP -0.11470102334147 0.0469359486345357 NA NA NA hsa-let-7a-3p ZSCAN12 0.167285443861993 0.431834813181487 0.0257173879080477 0.873993294367816 mirMAP -0.10279836870775 0.00909573642651884 NA NA NA