miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-30e-5p ABL1 1.60414100786743 3.78951090573667e-19 -0.0963586766222937 0.42908310012577 MirTarget;miRNATAP -0.113209719586126 0.000160465315502252 NA NA NA hsa-let-7b-5p ABL2 -1.62016148171663 1.56547487335694e-15 0.309042350704766 0.0156708848418577 miRNATAP -0.107317366483975 0.000129865371150028 NA NA NA hsa-let-7d-5p ABL2 -0.618145137285851 6.06067642715858e-05 0.309042350704766 0.0156708848418577 miRNATAP -0.127411976285756 0.000861287527124999 NA NA NA hsa-miR-125a-5p ABL2 -1.04824536696301 3.97386082850476e-07 0.309042350704766 0.0156708848418577 MirTarget;PITA -0.126986927641655 5.88927070713687e-06 26766902 MicroRNA 125a 5p modulates human cervical carcinoma proliferation and migration by targeting ABL2; The direct regulation of miR-125a-5p on its target gene ABL proto-oncogene 2 ABL2 in cervical carcinoma was evaluated by quantitative real-time reverse transcription polymerase chain reaction Western blotting and luciferase reporter assays respectively; ABL2 was shown to be directly targeted by miR-125a-5p; In cervical carcinoma ABL2 gene and protein levels were both downregulated by miR-125a-5p cervical and endocervical cancer hsa-miR-140-3p ABL2 -1.11373309124537 8.35257079443689e-14 0.309042350704766 0.0156708848418577 miRNAWalker2_validate -0.103829530406279 0.00742844267385625 NA NA NA hsa-miR-186-5p ABL2 0.852175445703945 6.88885738584309e-10 0.309042350704766 0.0156708848418577 MirTarget;mirMAP -0.102309420778672 0.0158979616816323 NA NA NA hsa-miR-200a-5p ABL2 2.26680634475411 1.52168554660094e-17 0.309042350704766 0.0156708848418577 mirMAP -0.110330494450507 1.7524732557597e-07 NA NA NA hsa-miR-200c-3p ABL2 0.380533388300368 0.0842181838538353 0.309042350704766 0.0156708848418577 MirTarget -0.136118058057993 2.82426446527059e-07 NA NA NA hsa-miR-29b-2-5p ABL2 0.345881055247341 0.194842633194187 0.309042350704766 0.0156708848418577 mirMAP -0.105014469771418 1.6245826631638e-06 NA NA NA hsa-miR-30a-3p ABL2 -2.54042202792785 2.9111625410859e-18 0.309042350704766 0.0156708848418577 mirMAP -0.101683437267616 1.20015028494104e-07 NA NA NA hsa-miR-30a-5p ABL2 -0.924084264430689 0.000762030454634728 0.309042350704766 0.0156708848418577 mirMAP;miRNATAP -0.113648915255007 7.21567378484659e-08 NA NA NA hsa-miR-30e-3p ABL2 -0.104420043859122 0.526240453209293 0.309042350704766 0.0156708848418577 mirMAP -0.173906109355795 1.16029480906672e-06 NA NA NA hsa-miR-361-5p ABL2 0.21454431962475 0.0800957579368424 0.309042350704766 0.0156708848418577 mirMAP -0.112484376205835 0.0217095709165268 NA NA NA hsa-let-7a-5p AKT2 -1.37014061604018 3.11451492971224e-14 0.158500088541505 0.113504798741429 TargetScan -0.119930037553526 1.13227688326527e-06 NA NA NA hsa-miR-29a-3p AKT2 0.101650412194573 0.573201097011668 0.158500088541505 0.113504798741429 MirTarget -0.104368014677354 4.26511869332683e-05 24076586 Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis acute myeloid leukemia hsa-miR-106b-5p AKT3 1.47447672652218 1.32004094930462e-13 -1.44031241124732 2.576504600149e-09 miRNATAP -0.158920731526324 0.00425859940487133 NA NA NA hsa-miR-107 AKT3 0.658676029898313 5.11480446318819e-07 -1.44031241124732 2.576504600149e-09 PITA;miRanda -0.256548300142307 0.00309702957622585 NA NA NA hsa-miR-146b-5p AKT3 1.0922867893808 5.63754607494775e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate -0.14508398550335 0.00188822517544197 NA NA NA hsa-miR-15a-5p AKT3 1.62575353599172 1.55312121019827e-19 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.412918804091755 4.08840965026726e-12 NA NA NA hsa-miR-16-5p AKT3 0.749619098384047 4.11649450706988e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.269698520974258 9.94440318719177e-05 NA NA NA hsa-miR-17-3p AKT3 1.36706429551147 4.60388403547821e-13 -1.44031241124732 2.576504600149e-09 miRNATAP -0.150903286752378 0.0102655088674849 NA NA NA hsa-miR-17-5p AKT3 2.07078488653279 2.77403038572568e-19 -1.44031241124732 2.576504600149e-09 TargetScan;miRNATAP -0.217476886844258 3.56953935954486e-06 NA NA NA hsa-miR-181a-5p AKT3 -0.375429731222937 0.0562142867129802 -1.44031241124732 2.576504600149e-09 miRNATAP -0.22550600060725 9.19470016250579e-05 NA NA NA hsa-miR-181b-5p AKT3 0.668793269169928 0.000239998092406404 -1.44031241124732 2.576504600149e-09 miRNATAP -0.367498754199467 2.09865276667175e-09 NA NA NA hsa-miR-20a-5p AKT3 2.64649625616975 5.1469418982085e-27 -1.44031241124732 2.576504600149e-09 miRNATAP -0.24430728120197 1.27608550819212e-08 NA NA NA hsa-miR-22-3p AKT3 1.42501909916631 1.72295005910055e-25 -1.44031241124732 2.576504600149e-09 miRNATAP -0.259390140878921 0.0010937362716222 NA NA NA hsa-miR-28-3p AKT3 0.387144500601444 0.00777919765254534 -1.44031241124732 2.576504600149e-09 miRNATAP -0.197315516871575 0.0122556173898666 NA NA NA hsa-miR-29a-3p AKT3 0.101650412194573 0.573201097011668 -1.44031241124732 2.576504600149e-09 miRNATAP -0.147280324253872 0.0201558550795979 NA NA NA hsa-miR-29b-2-5p AKT3 0.345881055247341 0.194842633194187 -1.44031241124732 2.576504600149e-09 mirMAP -0.181342398720756 1.80199534450665e-05 NA NA NA hsa-miR-29b-3p AKT3 3.10527711861309 3.01242507282711e-32 -1.44031241124732 2.576504600149e-09 miRNATAP -0.267243460090773 1.17871192498365e-11 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 0.653308707552535 0.0999497219778851 -1.44031241124732 2.576504600149e-09 mirMAP -0.18242132898273 2.34990243224026e-09 NA NA NA hsa-miR-335-3p AKT3 1.51116383169018 6.88553098788624e-13 -1.44031241124732 2.576504600149e-09 mirMAP -0.134576700675304 0.0106735082003925 NA NA NA hsa-miR-362-5p AKT3 0.658947634569393 0.0243306847205756 -1.44031241124732 2.576504600149e-09 PITA;TargetScan;miRNATAP -0.229571357984291 4.43564207755877e-09 NA NA NA hsa-miR-542-3p AKT3 1.62226640768239 2.6427102465476e-10 -1.44031241124732 2.576504600149e-09 miRanda -0.186790699816246 1.44501888663791e-05 NA NA NA hsa-miR-93-5p AKT3 1.50844106515467 1.83836866996875e-12 -1.44031241124732 2.576504600149e-09 miRNATAP -0.251105283811718 1.01733106411986e-06 NA NA NA hsa-miR-199a-3p ANGPT1 1.67715607711377 5.96963028176444e-15 -2.86129771115012 8.84824325579863e-17 PITA -0.146080222170555 0.0498324708910044 NA NA NA hsa-miR-199b-3p ANGPT1 1.67802185853505 6.03525898173555e-15 -2.86129771115012 8.84824325579863e-17 PITA -0.14673220751959 0.0486600273770658 NA NA NA hsa-miR-335-3p ANGPT1 1.51116383169018 6.88553098788624e-13 -2.86129771115012 8.84824325579863e-17 mirMAP -0.334486749250077 1.02763639483715e-05 NA NA NA hsa-miR-429 ANGPT1 2.3794516574089 1.72813419703734e-13 -2.86129771115012 8.84824325579863e-17 miRanda -0.251490713644337 2.2923141795107e-06 NA NA NA hsa-miR-590-3p ANGPT1 0.83851360565783 0.00129224433453587 -2.86129771115012 8.84824325579863e-17 PITA;miRanda;mirMAP -0.399492004581028 8.37484766920582e-08 NA NA NA hsa-miR-125a-5p ANGPT2 -1.04824536696301 3.97386082850476e-07 -0.355224254667991 0.234922406432455 miRanda -0.22928507808614 0.000503419130204071 NA NA NA hsa-miR-135b-5p ANGPT2 3.25019233805845 1.95560099639034e-15 -0.355224254667991 0.234922406432455 MirTarget -0.207372824603929 2.48196533716168e-09 NA NA NA hsa-miR-142-5p ANGPT2 1.29672439149353 4.0768822158894e-06 -0.355224254667991 0.234922406432455 MirTarget -0.151236689175521 0.00402617752870704 NA NA NA hsa-miR-186-5p ANGPT2 0.852175445703945 6.88885738584309e-10 -0.355224254667991 0.234922406432455 MirTarget;mirMAP -0.39229247734846 7.15903079089934e-05 NA NA NA hsa-miR-19b-3p ANGPT2 2.10868505662119 5.40846613768389e-17 -0.355224254667991 0.234922406432455 MirTarget -0.136227389947698 0.0146351480713043 NA NA NA hsa-miR-34c-5p ANGPT2 -1.00125440032112 0.0724432896090357 -0.355224254667991 0.234922406432455 miRanda -0.164341248696704 1.1475669197363e-10 NA NA NA hsa-miR-374a-5p ANGPT2 -0.197027254874826 0.298080902192861 -0.355224254667991 0.234922406432455 mirMAP -0.25710085678133 0.00170679143063428 NA NA NA hsa-miR-374b-5p ANGPT2 0.474691035780475 0.0109217471394203 -0.355224254667991 0.234922406432455 mirMAP -0.218997533012079 0.00511463662677723 NA NA NA hsa-miR-429 ANGPT2 2.3794516574089 1.72813419703734e-13 -0.355224254667991 0.234922406432455 miRanda -0.222922419850056 5.7113477777819e-07 NA NA NA hsa-miR-664a-3p ANGPT2 0.443077463053857 0.0214248925850984 -0.355224254667991 0.234922406432455 mirMAP -0.386891912279747 4.93812758809701e-08 NA NA NA hsa-miR-450a-5p ATP11A 1.94284269183615 1.52883075909271e-07 -0.297804706635747 0.274119720370221 mirMAP -0.258031860068113 4.46779253354972e-11 NA NA NA hsa-miR-10a-5p BDNF 0.790595816051606 0.000593731378445468 -3.58120361925577 1.66270299378731e-16 MirTarget;miRNATAP -0.279836886583095 0.00181387070495345 NA NA NA hsa-miR-146b-5p BDNF 1.0922867893808 5.63754607494775e-06 -3.58120361925577 1.66270299378731e-16 miRanda -0.328233255541106 0.000115785817710226 NA NA NA hsa-miR-148a-5p BDNF 1.45633512586855 1.81792463521257e-08 -3.58120361925577 1.66270299378731e-16 mirMAP -0.242376055234495 0.00212193071916532 NA NA NA hsa-miR-155-5p BDNF 0.813513839059142 0.000608282725633232 -3.58120361925577 1.66270299378731e-16 miRNATAP -0.23365712136721 0.00730981706859504 NA NA NA hsa-miR-15a-5p BDNF 1.62575353599172 1.55312121019827e-19 -3.58120361925577 1.66270299378731e-16 MirTarget;miRNATAP -0.299122819876483 0.00718936325191299 26581909 MicroRNA 15a 5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF; BDNF was then overexpressed in HepG2 and SNU-182 cells to evaluate its selective effect on miR-15a-5p in HCC modulation; MiR-15a-5p selectively and negatively regulated BDNF at both gene and protein levels in HCC cells; Forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-15a-5p on HCC proliferation and cell division in vitro; Our study demonstrated that miR-15a-5p is a tumor suppressor in HCC and its regulation is through BDNF in HCC liver cancer hsa-miR-182-5p BDNF 3.21839823004635 5.13049145201115e-39 -3.58120361925577 1.66270299378731e-16 MirTarget;miRNATAP -0.493312713509266 7.77762857641849e-11 NA NA NA hsa-miR-210-3p BDNF 4.89285936864822 4.81769290932762e-28 -3.58120361925577 1.66270299378731e-16 miRNAWalker2_validate;miRTarBase -0.223383828264906 2.32341714099671e-07 NA NA NA hsa-miR-22-3p BDNF 1.42501909916631 1.72295005910055e-25 -3.58120361925577 1.66270299378731e-16 miRNAWalker2_validate;miRTarBase -0.326241536330926 0.0251568912615143 NA NA NA hsa-miR-29b-1-5p BDNF 1.71024742617744 3.64915691793611e-09 -3.58120361925577 1.66270299378731e-16 mirMAP -0.254685357058655 0.000278466889584519 NA NA NA hsa-miR-30e-5p BDNF 1.60414100786743 3.78951090573667e-19 -3.58120361925577 1.66270299378731e-16 miRNATAP -0.435874001655586 8.84443032504441e-05 NA NA NA hsa-miR-452-3p BDNF 0.477736876273128 0.22218404598603 -3.58120361925577 1.66270299378731e-16 MirTarget -0.12722943253623 0.0392278584509154 NA NA NA hsa-miR-590-3p BDNF 0.83851360565783 0.00129224433453587 -3.58120361925577 1.66270299378731e-16 miRanda;mirMAP;miRNATAP -0.244097138557465 0.0103688075065083 NA NA NA hsa-miR-7-1-3p BDNF 2.61364240402652 1.98959237815786e-32 -3.58120361925577 1.66270299378731e-16 MirTarget -0.301669237992761 0.00109301980491166 NA NA NA hsa-miR-140-5p BRAP 0.669142684153918 0.000335928403032308 0.190327613324234 0.0329283892760999 miRanda -0.119862442956132 6.92393771946052e-08 NA NA NA hsa-miR-30a-5p BRAP -0.924084264430689 0.000762030454634728 0.190327613324234 0.0329283892760999 miRNATAP -0.102896105202578 1.21365801414025e-12 NA NA NA hsa-miR-30c-5p BRAP -0.327319105755825 0.123595832152687 0.190327613324234 0.0329283892760999 miRNATAP -0.119891953330813 2.55627836594766e-10 NA NA NA hsa-miR-194-5p CADM1 1.76979641760284 8.2064222072696e-05 -1.97539534457883 2.23181309519858e-09 miRNATAP -0.138655378128794 4.52826816990073e-05 NA NA NA hsa-miR-15a-5p CALM1 1.62575353599172 1.55312121019827e-19 -0.786934272058637 9.06030371306855e-15 miRNATAP -0.10983126561797 1.78170550956165e-05 NA NA NA hsa-miR-186-5p CALM1 0.852175445703945 6.88885738584309e-10 -0.786934272058637 9.06030371306855e-15 mirMAP -0.175559780048757 2.87104125593358e-07 NA NA NA hsa-miR-576-5p CALM1 1.02693643167056 1.14846964470173e-06 -0.786934272058637 9.06030371306855e-15 mirMAP -0.135458807383344 1.04049601747995e-09 NA NA NA hsa-miR-7-1-3p CALM1 2.61364240402652 1.98959237815786e-32 -0.786934272058637 9.06030371306855e-15 mirMAP -0.109108047540704 2.64629656204196e-07 NA NA NA hsa-miR-27b-3p CALM3 0.236438984240408 0.12263510345883 -0.124118759460306 0.234288875938605 miRNAWalker2_validate;miRNATAP -0.1725378364724 3.11982610153737e-08 NA NA NA hsa-miR-29a-3p CALM3 0.101650412194573 0.573201097011668 -0.124118759460306 0.234288875938605 miRNATAP -0.132873656445526 5.07799469344261e-07 NA NA NA hsa-miR-93-5p CALML4 1.50844106515467 1.83836866996875e-12 -0.270777477737382 0.0972767813822358 mirMAP -0.115789120311877 0.000729243330020676 NA NA NA hsa-miR-15a-5p CHUK 1.62575353599172 1.55312121019827e-19 0.0377297766878195 0.74424413982199 miRNAWalker2_validate;miRTarBase;MirTarget -0.156480048093973 2.55421092282135e-08 NA NA NA hsa-miR-29b-2-5p CHUK 0.345881055247341 0.194842633194187 0.0377297766878195 0.74424413982199 MirTarget -0.119533869512923 1.02102108327589e-09 NA NA NA hsa-miR-339-5p CHUK 0.536997313601114 0.0488090394176611 0.0377297766878195 0.74424413982199 miRanda -0.101676919866514 1.24374098863621e-07 NA NA NA hsa-miR-342-3p CHUK -0.128691966564961 0.561034080130801 0.0377297766878195 0.74424413982199 miRanda -0.176769532720248 4.41422217910121e-14 NA NA NA hsa-miR-497-5p CHUK -0.0546347378264729 0.786205564901684 0.0377297766878195 0.74424413982199 MirTarget -0.194599570543196 4.42801403790986e-14 NA NA NA hsa-miR-106a-5p CSF1 1.3902608059488 6.07931522284525e-05 -0.650264836121052 0.00786919304896235 miRNATAP -0.157656804933477 1.13944120373499e-05 NA NA NA hsa-miR-106b-5p CSF1 1.47447672652218 1.32004094930462e-13 -0.650264836121052 0.00786919304896235 miRNATAP -0.305783120990785 2.32822844592846e-08 NA NA NA hsa-miR-107 CSF1 0.658676029898313 5.11480446318819e-07 -0.650264836121052 0.00786919304896235 miRanda -0.324481705932923 0.00016709638617701 NA NA NA hsa-miR-128-3p CSF1 1.03509868349735 2.11606310588315e-10 -0.650264836121052 0.00786919304896235 MirTarget -0.18867678881791 0.00593057243578252 22909061 By mutations in putative miRNA targets in CSF-1 mRNA 3'UTR we identified a common target for both miR-128 and miR-152; We have also found that both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro two major aspects of the metastatic potential of cancer cells; Our results provide the evidence for a mechanism by which miR-128 and miR-152 down-regulate CSF-1 an important regulator of ovarian cancer motility ovarian cancer hsa-miR-130b-3p CSF1 1.83046548750752 5.04753914574694e-13 -0.650264836121052 0.00786919304896235 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.135196572862612 0.00318019283438574 22005523 CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system; CSF-1 expression was negatively associated with miR-130b level in ovarian tissues and cell lines; Luciferase assay validated CSF-1 is a direct target of miR-130b; Knock-down of CSF-1 sensitized ovarian cancer cells to anticancer drugs and could partially attenuate the resistance inducing effect of miR-130b inhibitors; Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1 and the silencing of miR-130b may be mediated by DNA methylation drug resistance ovarian cancer hsa-miR-148b-3p CSF1 0.483970528590224 0.0026495409465901 -0.650264836121052 0.00786919304896235 miRNAWalker2_validate -0.422070895660298 1.25558305987895e-09 NA NA NA hsa-miR-17-5p CSF1 2.07078488653279 2.77403038572568e-19 -0.650264836121052 0.00786919304896235 TargetScan;miRNATAP -0.306088841322867 3.52700354247209e-11 NA NA NA hsa-miR-20a-5p CSF1 2.64649625616975 5.1469418982085e-27 -0.650264836121052 0.00786919304896235 miRNATAP -0.250272644578681 4.83156805874136e-09 NA NA NA hsa-miR-335-5p CSF1 -0.466533891325811 0.0676987038122831 -0.650264836121052 0.00786919304896235 miRNAWalker2_validate -0.250864209186742 3.20501038060371e-07 NA NA NA hsa-miR-429 CSF1 2.3794516574089 1.72813419703734e-13 -0.650264836121052 0.00786919304896235 PITA;miRanda;miRNATAP -0.185165324027372 4.07583138622974e-07 NA NA NA hsa-miR-454-3p CSF1 1.49453641052169 4.46235742871434e-09 -0.650264836121052 0.00786919304896235 MirTarget;miRNATAP -0.123190772283051 0.0185846800088776 NA NA NA hsa-miR-93-5p CSF1 1.50844106515467 1.83836866996875e-12 -0.650264836121052 0.00786919304896235 miRNATAP -0.190058749425355 0.00022284034696416 NA NA NA hsa-miR-96-5p CSF1 3.0381097138467 4.40362891630201e-24 -0.650264836121052 0.00786919304896235 miRNATAP -0.149502063926274 0.00027907319742473 NA NA NA hsa-miR-107 CSF1R 0.658676029898313 5.11480446318819e-07 -0.654660428048424 0.0113734786538348 miRanda -0.417277311120845 4.28261039067918e-06 NA NA NA hsa-miR-194-5p CYTH3 1.76979641760284 8.2064222072696e-05 -0.309469134723996 0.142704432715622 mirMAP -0.165023707235615 2.18778387566444e-15 NA NA NA hsa-miR-194-5p DCBLD2 1.76979641760284 8.2064222072696e-05 0.329933232233546 0.247872135882458 MirTarget -0.199402947617204 2.00600152934295e-12 NA NA NA hsa-miR-194-5p DUSP9 1.76979641760284 8.2064222072696e-05 3.29795316192754 7.87940825565651e-08 MirTarget;miRNATAP -0.224156635451834 0.000384548218695216 NA NA NA hsa-miR-194-5p EDN1 1.76979641760284 8.2064222072696e-05 -2.36338320560248 2.32381924947795e-13 MirTarget;miRNATAP -0.135396580347777 5.32230104697634e-05 NA NA NA hsa-miR-218-5p EFNA1 -0.281408491748349 0.259553612322657 0.12611339673549 0.589690874025389 miRNAWalker2_validate -0.134029632827446 0.00247753786964095 NA NA NA hsa-miR-145-5p EFNA3 -1.34926078156437 2.63526538800669e-07 2.39841241673629 3.59658741816566e-20 miRNATAP -0.165896963340704 0.000435838250613543 NA NA NA hsa-miR-2110 EFNA3 -1.92124860612475 1.1464887721828e-12 2.39841241673629 3.59658741816566e-20 miRNATAP -0.149738081373567 0.00103641065869651 NA NA NA hsa-miR-221-5p EFNA3 -2.2173523967387 1.8954728277084e-09 2.39841241673629 3.59658741816566e-20 MirTarget -0.136736000341119 6.57070309154595e-05 NA NA NA hsa-miR-30a-5p EFNA3 -0.924084264430689 0.000762030454634728 2.39841241673629 3.59658741816566e-20 MirTarget;mirMAP;miRNATAP -0.323550479482298 3.19474292067047e-13 NA NA NA hsa-miR-30d-5p EFNA3 -0.920901858717441 3.50898334321668e-05 2.39841241673629 3.59658741816566e-20 MirTarget;mirMAP;miRNATAP -0.253322025389199 5.38120112437305e-06 NA NA NA hsa-miR-342-5p EFNA3 -0.382174669348421 0.0896996965047193 2.39841241673629 3.59658741816566e-20 miRNATAP -0.110244929781502 0.0487540158203846 NA NA NA hsa-miR-361-3p EFNA3 0.0988926195529967 0.549128728500555 2.39841241673629 3.59658741816566e-20 MirTarget;miRNATAP -0.210520640756772 0.00608274546614107 NA NA NA hsa-miR-423-5p EFNA3 -1.80309342242719 1.34791344187441e-19 2.39841241673629 3.59658741816566e-20 MirTarget;PITA;miRNATAP -0.300571019130052 5.7416909159278e-07 NA NA NA hsa-miR-486-5p EFNA3 -4.38592782786845 2.75864166493846e-29 2.39841241673629 3.59658741816566e-20 miRanda -0.234228131759917 9.92695316343125e-16 NA NA NA hsa-miR-1976 EFNA4 -1.27772236648866 7.13245221784788e-10 2.10340942087455 8.37475870788735e-26 MirTarget -0.103908882912465 0.0252148059389147 NA NA NA hsa-miR-125b-2-3p EFNA5 -1.71462405245374 1.47042341386638e-10 0.766518652762425 0.00961848889418976 MirTarget -0.128524386215276 0.0103503632163157 NA NA NA hsa-miR-140-5p EFNA5 0.669142684153918 0.000335928403032308 0.766518652762425 0.00961848889418976 miRanda -0.204976237889406 0.00644928467018422 NA NA NA hsa-miR-142-5p EFNA5 1.29672439149353 4.0768822158894e-06 0.766518652762425 0.00961848889418976 mirMAP;miRNATAP -0.132503401845735 0.0112129766410635 NA NA NA hsa-miR-150-5p EFNA5 -0.702328520623782 0.0215316651134431 0.766518652762425 0.00961848889418976 mirMAP;miRNATAP -0.118543563825026 0.00796270809631905 NA NA NA hsa-miR-15b-3p EFNA5 0.804736041893915 0.000400279611457186 0.766518652762425 0.00961848889418976 mirMAP -0.170641264441551 0.00700258649546722 NA NA NA hsa-miR-186-5p EFNA5 0.852175445703945 6.88885738584309e-10 0.766518652762425 0.00961848889418976 mirMAP -0.199579753114301 0.0431233143098348 NA NA NA hsa-miR-217 EFNA5 1.88358668330143 3.93795605235061e-07 0.766518652762425 0.00961848889418976 MirTarget;miRanda -0.117368715311579 0.00286681436397859 NA NA NA hsa-miR-335-3p EFNA5 1.51116383169018 6.88553098788624e-13 0.766518652762425 0.00961848889418976 mirMAP -0.185236590240764 0.00353795450372532 NA NA NA hsa-miR-335-5p EFNA5 -0.466533891325811 0.0676987038122831 0.766518652762425 0.00961848889418976 miRNAWalker2_validate -0.222326751872231 0.000200234786447207 NA NA NA hsa-miR-342-3p EFNA5 -0.128691966564961 0.561034080130801 0.766518652762425 0.00961848889418976 miRNATAP -0.171626597394371 0.00564714427078974 NA NA NA hsa-miR-362-3p EFNA5 0.194097672030785 0.52808475179225 0.766518652762425 0.00961848889418976 miRanda -0.151234117297808 0.00657303041936921 NA NA NA hsa-miR-378a-3p EFNA5 -2.0140903990983 1.146745431034e-18 0.766518652762425 0.00961848889418976 miRNATAP -0.175477598420107 0.00232847823669233 NA NA NA hsa-miR-378c EFNA5 -1.1528833105561 7.25986666044199e-07 0.766518652762425 0.00961848889418976 miRNATAP -0.1476472554038 0.0114161167212389 NA NA NA hsa-miR-421 EFNA5 0.170525317701774 0.535277026680289 0.766518652762425 0.00961848889418976 mirMAP -0.211368335666247 8.74421427145838e-05 NA NA NA hsa-miR-501-5p EFNA5 0.411357595674671 0.10435288464149 0.766518652762425 0.00961848889418976 mirMAP -0.169021809608922 0.00174145021645448 NA NA NA hsa-miR-92a-3p EFNA5 -0.136362762339122 0.493412263619364 0.766518652762425 0.00961848889418976 miRNAWalker2_validate -0.14391959566013 0.0375225802136783 NA NA NA hsa-miR-126-5p EGFR 0.851637714492907 0.000391373420568359 -0.271157231776117 0.423394925561077 mirMAP -0.139683005020176 0.0311384807179421 NA NA NA hsa-miR-141-3p EGFR 3.36993755486106 5.42939251147195e-32 -0.271157231776117 0.423394925561077 MirTarget -0.182043268046231 0.000322561477910029 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-142-3p EGFR 3.98476449801341 1.56256182021111e-35 -0.271157231776117 0.423394925561077 miRanda -0.13728647251485 0.00224315827652832 NA NA NA hsa-miR-148b-5p EGFR 1.39335695292409 2.13220380550073e-07 -0.271157231776117 0.423394925561077 mirMAP -0.312208825866794 5.03093953543843e-06 NA NA NA hsa-miR-16-5p EGFR 0.749619098384047 4.11649450706988e-06 -0.271157231776117 0.423394925561077 miRNAWalker2_validate -0.236322665103673 0.0136370655603559 NA NA NA hsa-miR-17-5p EGFR 2.07078488653279 2.77403038572568e-19 -0.271157231776117 0.423394925561077 TargetScan -0.227660150278677 0.000449250209613956 NA NA NA hsa-miR-186-5p EGFR 0.852175445703945 6.88885738584309e-10 -0.271157231776117 0.423394925561077 mirMAP -0.237997116687489 0.0344443859175798 NA NA NA hsa-miR-192-5p EGFR 2.03412119423736 1.6357945826287e-05 -0.271157231776117 0.423394925561077 mirMAP -0.148537455733138 4.68324614985853e-06 NA NA NA hsa-miR-19b-1-5p EGFR 1.71217036351784 3.28561659177495e-12 -0.271157231776117 0.423394925561077 MirTarget;mirMAP -0.196763487131799 0.00607880458029935 NA NA NA hsa-miR-200a-3p EGFR 3.14766878548496 1.32850889777422e-21 -0.271157231776117 0.423394925561077 MirTarget -0.135522178803702 0.00339714885174827 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-320b EGFR 0.226640952564488 0.378818692487242 -0.271157231776117 0.423394925561077 miRanda;mirMAP -0.169207384217798 0.00529161513582327 NA NA NA hsa-miR-335-5p EGFR -0.466533891325811 0.0676987038122831 -0.271157231776117 0.423394925561077 miRNAWalker2_validate -0.183988914461652 0.00717835650953039 NA NA NA hsa-miR-342-3p EGFR -0.128691966564961 0.561034080130801 -0.271157231776117 0.423394925561077 miRanda -0.14410083601866 0.0420201531461371 NA NA NA hsa-miR-375 EGFR 0.615547997686534 0.149199273675144 -0.271157231776117 0.423394925561077 miRanda -0.181944225035217 4.73664955454239e-07 NA NA NA hsa-miR-590-3p EGFR 0.83851360565783 0.00129224433453587 -0.271157231776117 0.423394925561077 mirMAP -0.155001504616297 0.0306827580170387 NA NA NA hsa-miR-590-5p EGFR 2.07441240363458 4.95240551694843e-14 -0.271157231776117 0.423394925561077 miRanda;mirMAP -0.170204148802389 0.012927364020379 NA NA NA hsa-miR-940 EPHA2 0.011138136211269 0.974925352379525 -0.364933990274224 0.225946505222038 miRNAWalker2_validate -0.117179593758916 0.00777902546926027 NA NA NA hsa-miR-1180-3p ETS1 -0.436557784255953 0.0682615670979027 -1.33464832702169 1.2741718546326e-11 MirTarget -0.134127484591041 0.00053654504385828 NA NA NA hsa-miR-130b-5p ETS1 1.53645187062942 1.10498816261505e-08 -1.33464832702169 1.2741718546326e-11 MirTarget -0.209791843945431 3.49567001266862e-10 NA NA NA hsa-miR-141-3p ETS1 3.36993755486106 5.42939251147195e-32 -1.33464832702169 1.2741718546326e-11 mirMAP -0.28525386643044 4.22934005879623e-23 NA NA NA hsa-miR-141-5p ETS1 3.02575703771074 1.54385222591327e-32 -1.33464832702169 1.2741718546326e-11 mirMAP -0.262530557520147 1.65892547983942e-15 NA NA NA hsa-miR-148b-5p ETS1 1.39335695292409 2.13220380550073e-07 -1.33464832702169 1.2741718546326e-11 MirTarget -0.261119775407055 8.96934923930909e-11 NA NA NA hsa-miR-16-1-3p ETS1 1.50034693398929 6.63958242991125e-10 -1.33464832702169 1.2741718546326e-11 MirTarget -0.171518779700711 0.000230305413582585 NA NA NA hsa-miR-181b-5p ETS1 0.668793269169928 0.000239998092406404 -1.33464832702169 1.2741718546326e-11 MirTarget;miRNATAP -0.138239039511906 0.00674249587378248 NA NA NA hsa-miR-181d-5p ETS1 1.19058140522592 8.5908558852417e-09 -1.33464832702169 1.2741718546326e-11 MirTarget -0.170803114290139 0.000110151584896094 NA NA NA hsa-miR-186-5p ETS1 0.852175445703945 6.88885738584309e-10 -1.33464832702169 1.2741718546326e-11 mirMAP -0.276314696621125 3.29043806611271e-05 NA NA NA hsa-miR-200a-3p ETS1 3.14766878548496 1.32850889777422e-21 -1.33464832702169 1.2741718546326e-11 mirMAP -0.224321028047949 3.87375400243837e-17 NA NA NA hsa-miR-200b-3p ETS1 1.55157578247391 4.83790020897188e-09 -1.33464832702169 1.2741718546326e-11 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.250568236368063 8.80774508313921e-14 NA NA NA hsa-miR-200c-3p ETS1 0.380533388300368 0.0842181838538353 -1.33464832702169 1.2741718546326e-11 MirTarget;miRNATAP -0.276826185450644 2.349762852801e-11 NA NA NA hsa-miR-27b-5p ETS1 1.03511957999268 7.86187917705303e-11 -1.33464832702169 1.2741718546326e-11 MirTarget;miRNATAP -0.214668848209625 0.000187170592397013 NA NA NA hsa-miR-29a-5p ETS1 1.89519956688438 1.03453349363915e-11 -1.33464832702169 1.2741718546326e-11 MirTarget;miRNATAP -0.151719929976573 9.32342936655572e-05 NA NA NA hsa-miR-30d-3p ETS1 0.00396376345349925 0.986457040013182 -1.33464832702169 1.2741718546326e-11 mirMAP -0.114829692131667 0.010305396718784 NA NA NA hsa-miR-335-3p ETS1 1.51116383169018 6.88553098788624e-13 -1.33464832702169 1.2741718546326e-11 mirMAP -0.254871095653828 2.01801486191042e-09 NA NA NA hsa-miR-429 ETS1 2.3794516574089 1.72813419703734e-13 -1.33464832702169 1.2741718546326e-11 MirTarget;PITA;miRanda;miRNATAP -0.249957740089923 1.46683561780832e-17 NA NA NA hsa-miR-450b-5p ETS1 1.69248953402469 1.96052058003353e-07 -1.33464832702169 1.2741718546326e-11 miRNATAP -0.107902391733614 0.000594653750023677 NA NA NA hsa-miR-501-5p ETS1 0.411357595674671 0.10435288464149 -1.33464832702169 1.2741718546326e-11 mirMAP -0.188072352083973 2.25462398506679e-07 NA NA NA hsa-miR-576-5p ETS1 1.02693643167056 1.14846964470173e-06 -1.33464832702169 1.2741718546326e-11 mirMAP -0.128860138222501 0.0031355097835793 NA NA NA hsa-miR-590-5p ETS1 2.07441240363458 4.95240551694843e-14 -1.33464832702169 1.2741718546326e-11 miRanda -0.235519916698206 4.49199678516619e-09 NA NA NA hsa-miR-660-5p ETS1 2.04875198906126 1.08269480928897e-17 -1.33464832702169 1.2741718546326e-11 MirTarget -0.169236243535995 9.40017177777573e-06 NA NA NA hsa-miR-664a-3p ETS1 0.443077463053857 0.0214248925850984 -1.33464832702169 1.2741718546326e-11 mirMAP -0.198008754375162 3.91837537911893e-05 NA NA NA hsa-miR-7-1-3p ETS1 2.61364240402652 1.98959237815786e-32 -1.33464832702169 1.2741718546326e-11 mirMAP -0.203358410365934 7.39762540033299e-07 NA NA NA hsa-miR-146b-5p ETS2 1.0922867893808 5.63754607494775e-06 -1.07837822369396 1.02757327787067e-07 miRanda -0.13598919483464 0.000473965232320593 NA NA NA hsa-miR-199a-3p ETS2 1.67715607711377 5.96963028176444e-15 -1.07837822369396 1.02757327787067e-07 miRNAWalker2_validate -0.197373279554156 3.41679620041364e-06 NA NA NA hsa-miR-199a-5p ETS2 1.3057193856884 2.38429382751645e-08 -1.07837822369396 1.02757327787067e-07 miRNAWalker2_validate;miRanda;miRNATAP -0.110295023711849 0.00571444527619097 NA NA NA hsa-miR-221-3p ETS2 -0.0986794612964683 0.654454148658401 -1.07837822369396 1.02757327787067e-07 miRNATAP -0.148492586114387 0.000551448141578173 NA NA NA hsa-miR-222-3p ETS2 0.0327210697409583 0.881937768109611 -1.07837822369396 1.02757327787067e-07 miRNATAP -0.19913415021421 3.27196802911867e-06 NA NA NA hsa-miR-30e-5p ETS2 1.60414100786743 3.78951090573667e-19 -1.07837822369396 1.02757327787067e-07 mirMAP -0.11241701015902 0.0275699496253045 NA NA NA hsa-miR-450b-5p ETS2 1.69248953402469 1.96052058003353e-07 -1.07837822369396 1.02757327787067e-07 miRNATAP -0.145210598038881 5.15795753769702e-06 NA NA NA hsa-miR-590-3p ETS2 0.83851360565783 0.00129224433453587 -1.07837822369396 1.02757327787067e-07 miRanda -0.150314905757415 0.000521886059798468 NA NA NA hsa-let-7e-5p FASLG -0.749418249305995 7.34668338492227e-05 0.227219484524508 0.525243087995098 miRNATAP -0.243056494896728 0.00520293662614488 NA NA NA hsa-miR-126-5p FGF1 0.851637714492907 0.000391373420568359 -0.577676136313124 0.0506048044371249 mirMAP -0.135027379551909 0.0170437002634768 NA NA NA hsa-miR-16-1-3p FGF1 1.50034693398929 6.63958242991125e-10 -0.577676136313124 0.0506048044371249 mirMAP -0.264990724395016 0.000104336880288483 NA NA NA hsa-miR-186-5p FGF1 0.852175445703945 6.88885738584309e-10 -0.577676136313124 0.0506048044371249 mirMAP -0.468236590634635 1.51395461317672e-06 NA NA NA hsa-miR-18a-5p FGF1 1.37435209536521 9.2173853686829e-06 -0.577676136313124 0.0506048044371249 MirTarget -0.313741396264592 1.24482978490312e-11 NA NA NA hsa-miR-320b FGF1 0.226640952564488 0.378818692487242 -0.577676136313124 0.0506048044371249 miRanda -0.145122007313635 0.00620299731128628 NA NA NA hsa-miR-330-5p FGF1 0.168520831101569 0.336433937906706 -0.577676136313124 0.0506048044371249 miRanda;miRNATAP -0.396337147508732 3.26538084155222e-07 NA NA NA hsa-miR-429 FGF1 2.3794516574089 1.72813419703734e-13 -0.577676136313124 0.0506048044371249 miRNATAP -0.116223459446297 0.00906049231323183 NA NA NA hsa-miR-484 FGF1 -0.228576985124486 0.244112867390855 -0.577676136313124 0.0506048044371249 MirTarget;PITA;miRNATAP -0.169358885680603 0.015389742903039 NA NA NA hsa-miR-532-3p FGF1 -0.677758187385834 0.0147557885796065 -0.577676136313124 0.0506048044371249 miRNATAP -0.106505407094692 0.029825431820242 NA NA NA hsa-miR-576-5p FGF1 1.02693643167056 1.14846964470173e-06 -0.577676136313124 0.0506048044371249 PITA;mirMAP -0.353451864713746 2.30476528411685e-08 NA NA NA hsa-miR-590-5p FGF1 2.07441240363458 4.95240551694843e-14 -0.577676136313124 0.0506048044371249 MirTarget;miRanda;miRNATAP -0.188750550916759 0.00157081419432906 NA NA NA hsa-miR-629-5p FGF1 1.31657090341737 1.45711558652127e-12 -0.577676136313124 0.0506048044371249 MirTarget -0.255543406785593 0.000362449168272974 NA NA NA hsa-miR-7-5p FGF1 0.343825848926135 0.435063427976906 -0.577676136313124 0.0506048044371249 miRNAWalker2_validate -0.167943341210869 1.20539892015732e-05 NA NA NA hsa-let-7a-5p FGF11 -1.37014061604018 3.11451492971224e-14 3.58238481677861 7.07821884742881e-23 TargetScan;mirMAP;miRNATAP -0.568985035003898 1.41653445623786e-09 NA NA NA hsa-let-7b-5p FGF11 -1.62016148171663 1.56547487335694e-15 3.58238481677861 7.07821884742881e-23 mirMAP;miRNATAP -0.480829455651022 7.33790550378727e-09 NA NA NA hsa-let-7d-5p FGF11 -0.618145137285851 6.06067642715858e-05 3.58238481677861 7.07821884742881e-23 mirMAP;miRNATAP -0.403117661585255 0.000426361486333792 NA NA NA hsa-let-7f-5p FGF11 -0.0523311272618407 0.83407808268787 3.58238481677861 7.07821884742881e-23 mirMAP;miRNATAP -0.179818463200275 0.0110568080471292 NA NA NA hsa-miR-125a-5p FGF11 -1.04824536696301 3.97386082850476e-07 3.58238481677861 7.07821884742881e-23 mirMAP -0.283106012258554 0.000790298136640464 NA NA NA hsa-miR-195-5p FGF11 -1.01577502605386 4.80814718341729e-05 3.58238481677861 7.07821884742881e-23 mirMAP -0.276250424568979 0.000176750217569729 NA NA NA hsa-miR-221-5p FGF11 -2.2173523967387 1.8954728277084e-09 3.58238481677861 7.07821884742881e-23 miRNATAP -0.140867639708279 0.00355614353073565 NA NA NA hsa-miR-320a FGF11 -0.961144925954715 1.62478794429204e-08 3.58238481677861 7.07821884742881e-23 miRanda -0.314554800922091 0.00217972507442822 NA NA NA hsa-miR-326 FGF11 -0.992397386750901 0.00335173765975096 3.58238481677861 7.07821884742881e-23 MirTarget;PITA;miRanda;miRNATAP -0.120923868229744 0.0198503101381869 NA NA NA hsa-miR-335-5p FGF11 -0.466533891325811 0.0676987038122831 3.58238481677861 7.07821884742881e-23 miRNAWalker2_validate;mirMAP -0.256647530759583 0.000881158505615166 NA NA NA hsa-let-7a-3p FGF12 0.167285443861993 0.431834813181487 -0.540341291347842 0.2437250465075 MirTarget -0.251674811310452 0.0260531720786865 NA NA NA hsa-let-7b-3p FGF12 -1.81889978084306 6.9913416210266e-19 -0.540341291347842 0.2437250465075 MirTarget -0.28093879604846 0.0051773171700438 NA NA NA hsa-miR-200b-3p FGF12 1.55157578247391 4.83790020897188e-09 -0.540341291347842 0.2437250465075 TargetScan -0.237021249202824 0.00277049015484138 NA NA NA hsa-miR-29a-5p FGF12 1.89519956688438 1.03453349363915e-11 -0.540341291347842 0.2437250465075 MirTarget -0.276278524444419 0.00204171562114313 NA NA NA hsa-miR-3065-5p FGF12 0.653308707552535 0.0999497219778851 -0.540341291347842 0.2437250465075 mirMAP -0.219717935817458 0.000160441200217862 NA NA NA hsa-miR-362-3p FGF12 0.194097672030785 0.52808475179225 -0.540341291347842 0.2437250465075 miRanda -0.17537705927891 0.0440010389499828 NA NA NA hsa-miR-429 FGF12 2.3794516574089 1.72813419703734e-13 -0.540341291347842 0.2437250465075 miRNATAP -0.210520637292102 0.0025270091646609 NA NA NA hsa-miR-455-5p FGF12 1.36946341828134 5.05118627562807e-08 -0.540341291347842 0.2437250465075 miRanda -0.291759936628716 0.0026130555582076 NA NA NA hsa-miR-511-5p FGF12 -0.299232651841262 0.292871281649728 -0.540341291347842 0.2437250465075 MirTarget -0.342048393598124 4.53535066794083e-06 NA NA NA hsa-miR-141-3p FGF13 3.36993755486106 5.42939251147195e-32 0.0874395647550581 0.810556248943047 TargetScan -0.199819863219093 0.000244921517068874 NA NA NA hsa-miR-338-5p FGF13 -1.83316380675941 4.03269924759167e-07 0.0874395647550581 0.810556248943047 PITA -0.175986648309995 0.000113756652771771 NA NA NA hsa-miR-421 FGF14 0.170525317701774 0.535277026680289 -1.420755529251 1.88430020060794e-06 miRanda -0.341718556233856 2.50791289827731e-10 NA NA NA hsa-miR-590-3p FGF14 0.83851360565783 0.00129224433453587 -1.420755529251 1.88430020060794e-06 miRanda -0.434093352571676 3.47983378758532e-12 NA NA NA hsa-miR-96-5p FGF14 3.0381097138467 4.40362891630201e-24 -1.420755529251 1.88430020060794e-06 TargetScan -0.342893565188291 4.97164511915916e-12 NA NA NA hsa-miR-15a-5p FGF18 1.62575353599172 1.55312121019827e-19 -2.01878202132787 1.47991026443687e-06 miRNATAP -0.247661094032716 0.0183699147433198 NA NA NA hsa-miR-16-5p FGF18 0.749619098384047 4.11649450706988e-06 -2.01878202132787 1.47991026443687e-06 miRNATAP -0.278033638119358 0.0206297444111895 NA NA NA hsa-miR-21-5p FGF18 4.38165933891779 1.52536633902505e-92 -2.01878202132787 1.47991026443687e-06 miRNATAP -0.445995016466712 1.11879820670501e-09 NA NA NA hsa-miR-424-5p FGF18 1.26485330287919 6.1498991028257e-06 -2.01878202132787 1.47991026443687e-06 miRNATAP -0.208512227284213 0.00257215272427139 NA NA NA hsa-miR-590-5p FGF18 2.07441240363458 4.95240551694843e-14 -2.01878202132787 1.47991026443687e-06 miRanda;miRNATAP -0.29033796179898 0.000691235501435991 NA NA NA hsa-miR-9-5p FGF18 4.99250901331516 2.59132733422801e-19 -2.01878202132787 1.47991026443687e-06 miRNATAP -0.161460646965575 1.31749803347013e-06 NA NA NA hsa-miR-107 FGF2 0.658676029898313 5.11480446318819e-07 -2.54526710952658 2.81433930536102e-18 MirTarget;PITA;miRanda;miRNATAP -0.244496430236947 0.022561363743936 NA NA NA hsa-miR-1226-3p FGF2 -1.00799676115747 0.00514693761539554 -2.54526710952658 2.81433930536102e-18 MirTarget -0.110812860105066 0.0144343058262069 NA NA NA hsa-miR-142-3p FGF2 3.98476449801341 1.56256182021111e-35 -2.54526710952658 2.81433930536102e-18 miRanda -0.108425653539561 0.00717069701654876 NA NA NA hsa-miR-15a-5p FGF2 1.62575353599172 1.55312121019827e-19 -2.54526710952658 2.81433930536102e-18 MirTarget;miRNATAP -0.36038112870066 1.28425682158144e-06 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 0.804736041893915 0.000400279611457186 -2.54526710952658 2.81433930536102e-18 mirMAP -0.158566214646418 0.0143454274716861 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 1.50034693398929 6.63958242991125e-10 -2.54526710952658 2.81433930536102e-18 mirMAP -0.257821575620002 0.000236815470978822 NA NA NA hsa-miR-16-2-3p FGF2 0.503964803530872 0.0263648405197492 -2.54526710952658 2.81433930536102e-18 mirMAP -0.138415775039185 0.0391981206400124 NA NA NA hsa-miR-181b-5p FGF2 0.668793269169928 0.000239998092406404 -2.54526710952658 2.81433930536102e-18 mirMAP -0.262170032088161 0.000626951093969658 NA NA NA hsa-miR-186-5p FGF2 0.852175445703945 6.88885738584309e-10 -2.54526710952658 2.81433930536102e-18 miRNAWalker2_validate;mirMAP -0.312620722879404 0.00189105104228049 NA NA NA hsa-miR-19b-1-5p FGF2 1.71217036351784 3.28561659177495e-12 -2.54526710952658 2.81433930536102e-18 mirMAP -0.32669324350081 2.87433739267694e-07 NA NA NA hsa-miR-200b-3p FGF2 1.55157578247391 4.83790020897188e-09 -2.54526710952658 2.81433930536102e-18 mirMAP -0.237329951619637 4.11083003299206e-06 NA NA NA hsa-miR-200c-3p FGF2 0.380533388300368 0.0842181838538353 -2.54526710952658 2.81433930536102e-18 mirMAP -0.303839594432928 1.47159143745806e-06 NA NA NA hsa-miR-20a-3p FGF2 2.51803599558247 4.92479325298629e-13 -2.54526710952658 2.81433930536102e-18 mirMAP -0.234318235832673 2.96971224443726e-06 NA NA NA hsa-miR-21-3p FGF2 2.54206008030157 1.11598785398763e-30 -2.54526710952658 2.81433930536102e-18 mirMAP -0.372000947223037 1.77917903992197e-10 NA NA NA hsa-miR-21-5p FGF2 4.38165933891779 1.52536633902505e-92 -2.54526710952658 2.81433930536102e-18 mirMAP -0.439558209079983 1.20994163416464e-17 NA NA NA hsa-miR-29a-5p FGF2 1.89519956688438 1.03453349363915e-11 -2.54526710952658 2.81433930536102e-18 mirMAP -0.365049356850144 2.5272073429353e-10 NA NA NA hsa-miR-32-5p FGF2 0.876853679269853 6.04859399018691e-05 -2.54526710952658 2.81433930536102e-18 miRNAWalker2_validate -0.179124683112376 0.00965081572899845 NA NA NA hsa-miR-335-3p FGF2 1.51116383169018 6.88553098788624e-13 -2.54526710952658 2.81433930536102e-18 mirMAP -0.374424532101383 5.108451362917e-09 NA NA NA hsa-miR-424-5p FGF2 1.26485330287919 6.1498991028257e-06 -2.54526710952658 2.81433930536102e-18 MirTarget;miRNATAP -0.119882551286833 0.015582276067481 NA NA NA hsa-miR-429 FGF2 2.3794516574089 1.72813419703734e-13 -2.54526710952658 2.81433930536102e-18 mirMAP -0.274666460864277 1.00411224771278e-09 NA NA NA hsa-miR-450b-5p FGF2 1.69248953402469 1.96052058003353e-07 -2.54526710952658 2.81433930536102e-18 mirMAP -0.165505837504251 0.000468241696245016 NA NA NA hsa-miR-503-5p FGF2 1.97129438815516 2.1704434283035e-09 -2.54526710952658 2.81433930536102e-18 miRNAWalker2_validate -0.205012336037686 7.26622582895517e-07 NA NA NA hsa-miR-589-3p FGF2 1.34253876396688 1.84935927493927e-05 -2.54526710952658 2.81433930536102e-18 mirMAP -0.178139639483111 8.93094177354748e-05 NA NA NA hsa-miR-590-3p FGF2 0.83851360565783 0.00129224433453587 -2.54526710952658 2.81433930536102e-18 miRanda;mirMAP -0.152562321238593 0.0176134514846273 NA NA NA hsa-miR-590-5p FGF2 2.07441240363458 4.95240551694843e-14 -2.54526710952658 2.81433930536102e-18 miRanda;mirMAP -0.34395539570476 1.33985562743507e-08 NA NA NA hsa-miR-664a-3p FGF2 0.443077463053857 0.0214248925850984 -2.54526710952658 2.81433930536102e-18 mirMAP -0.170090608436865 0.0197428993134175 NA NA NA hsa-miR-92a-3p FGF2 -0.136362762339122 0.493412263619364 -2.54526710952658 2.81433930536102e-18 miRNAWalker2_validate -0.165928138855031 0.0189625719856069 NA NA NA hsa-miR-93-3p FGF2 1.07631808403007 1.63747525692813e-05 -2.54526710952658 2.81433930536102e-18 mirMAP -0.263196364039628 1.81238194047644e-06 NA NA NA hsa-miR-3065-5p FGF5 0.653308707552535 0.0999497219778851 1.41965936869673 0.00663601545902237 mirMAP -0.30851318309695 2.58273355476571e-06 NA NA NA hsa-miR-30a-5p FGF5 -0.924084264430689 0.000762030454634728 1.41965936869673 0.00663601545902237 mirMAP -0.458682122515636 1.23681430790792e-07 NA NA NA hsa-miR-30b-5p FGF5 0.358144314839612 0.138026229059594 1.41965936869673 0.00663601545902237 mirMAP -0.539045077966163 5.42071635746139e-08 NA NA NA hsa-miR-30c-5p FGF5 -0.327319105755825 0.123595832152687 1.41965936869673 0.00663601545902237 mirMAP -0.720160664714379 1.3358272407005e-10 NA NA NA hsa-miR-30d-5p FGF5 -0.920901858717441 3.50898334321668e-05 1.41965936869673 0.00663601545902237 mirMAP -0.922796453852226 7.74508150171104e-19 NA NA NA hsa-miR-30e-5p FGF5 1.60414100786743 3.78951090573667e-19 1.41965936869673 0.00663601545902237 mirMAP -0.42672903139199 0.00102753035462209 NA NA NA hsa-miR-338-3p FGF5 0.726843067232002 0.0506251324215494 1.41965936869673 0.00663601545902237 miRanda -0.249982640438075 0.000108939596018716 NA NA NA hsa-miR-486-5p FGF5 -4.38592782786845 2.75864166493846e-29 1.41965936869673 0.00663601545902237 miRanda -0.172915883890662 0.0028302765942552 NA NA NA hsa-miR-500a-5p FGF5 0.648155655714409 0.0104657432932038 1.41965936869673 0.00663601545902237 mirMAP -0.391631377809049 5.96983250124773e-05 NA NA NA hsa-miR-501-5p FGF5 0.411357595674671 0.10435288464149 1.41965936869673 0.00663601545902237 PITA;mirMAP -0.425344723856289 7.43244452614636e-06 NA NA NA hsa-miR-107 FGF7 0.658676029898313 5.11480446318819e-07 -1.35096332880614 7.44222727225117e-07 PITA;miRanda;miRNATAP -0.384064720888837 7.51486049064498e-05 NA NA NA hsa-miR-15a-5p FGF7 1.62575353599172 1.55312121019827e-19 -1.35096332880614 7.44222727225117e-07 miRTarBase;miRNATAP -0.466793239192838 2.83453139790815e-12 NA NA NA hsa-miR-15b-5p FGF7 -1.25935038177398 1.83460220856901e-12 -1.35096332880614 7.44222727225117e-07 miRNATAP -0.195108702684649 0.00524641292904446 NA NA NA hsa-miR-16-1-3p FGF7 1.50034693398929 6.63958242991125e-10 -1.35096332880614 7.44222727225117e-07 mirMAP -0.415291526592944 3.77942867633909e-11 NA NA NA hsa-miR-16-2-3p FGF7 0.503964803530872 0.0263648405197492 -1.35096332880614 7.44222727225117e-07 mirMAP -0.32685238601193 5.84459614417273e-08 NA NA NA hsa-miR-16-5p FGF7 0.749619098384047 4.11649450706988e-06 -1.35096332880614 7.44222727225117e-07 miRNATAP -0.360407939054601 3.33302283380507e-06 NA NA NA hsa-miR-20a-5p FGF7 2.64649625616975 5.1469418982085e-27 -1.35096332880614 7.44222727225117e-07 miRNAWalker2_validate -0.394356736375477 7.25466480479139e-17 NA NA NA hsa-miR-26b-5p FGF7 0.72362441215247 4.7794659748036e-05 -1.35096332880614 7.44222727225117e-07 mirMAP -0.172407935731464 0.0159347831153386 NA NA NA hsa-miR-421 FGF7 0.170525317701774 0.535277026680289 -1.35096332880614 7.44222727225117e-07 miRanda -0.163761788143437 0.00112347767405943 NA NA NA hsa-miR-424-5p FGF7 1.26485330287919 6.1498991028257e-06 -1.35096332880614 7.44222727225117e-07 miRNATAP -0.106475207565034 0.018260802450975 NA NA NA hsa-miR-429 FGF7 2.3794516574089 1.72813419703734e-13 -1.35096332880614 7.44222727225117e-07 miRNATAP -0.236095541262009 8.5203274937411e-09 NA NA NA hsa-miR-501-5p FGF7 0.411357595674671 0.10435288464149 -1.35096332880614 7.44222727225117e-07 PITA;mirMAP -0.240038572692252 1.49297440376449e-06 NA NA NA hsa-miR-590-3p FGF7 0.83851360565783 0.00129224433453587 -1.35096332880614 7.44222727225117e-07 PITA;miRanda;mirMAP;miRNATAP -0.153768635331909 0.00851407916887242 NA NA NA hsa-miR-590-5p FGF7 2.07441240363458 4.95240551694843e-14 -1.35096332880614 7.44222727225117e-07 PITA;miRanda -0.342399846177336 4.47018629152173e-10 NA NA NA hsa-miR-7-1-3p FGF7 2.61364240402652 1.98959237815786e-32 -1.35096332880614 7.44222727225117e-07 mirMAP -0.317243751289801 1.53104453627605e-08 NA NA NA hsa-miR-142-3p FGF9 3.98476449801341 1.56256182021111e-35 -1.33489997634345 0.0119359510527769 miRanda -0.297024649065488 2.41524362922675e-05 NA NA NA hsa-miR-142-5p FGF9 1.29672439149353 4.0768822158894e-06 -1.33489997634345 0.0119359510527769 mirMAP -0.338742204386594 0.000287338979970239 NA NA NA hsa-miR-155-5p FGF9 0.813513839059142 0.000608282725633232 -1.33489997634345 0.0119359510527769 miRNATAP -0.256485432831109 0.012893377341639 NA NA NA hsa-miR-16-2-3p FGF9 0.503964803530872 0.0263648405197492 -1.33489997634345 0.0119359510527769 mirMAP -0.43168768681555 0.000229313476417954 NA NA NA hsa-miR-16-5p FGF9 0.749619098384047 4.11649450706988e-06 -1.33489997634345 0.0119359510527769 miRNATAP -0.466038608257105 0.00194558955642264 NA NA NA hsa-miR-212-3p FGF9 0.404496907089793 0.103551762277891 -1.33489997634345 0.0119359510527769 mirMAP -0.264431225714465 0.00749196276633432 NA NA NA hsa-miR-3607-3p FGF9 2.4103172144469 2.69039449048047e-08 -1.33489997634345 0.0119359510527769 miRNATAP -0.124289142551772 0.025638523876186 NA NA NA hsa-miR-424-5p FGF9 1.26485330287919 6.1498991028257e-06 -1.33489997634345 0.0119359510527769 miRNATAP -0.299762934200373 0.000543050338372439 NA NA NA hsa-miR-450b-5p FGF9 1.69248953402469 1.96052058003353e-07 -1.33489997634345 0.0119359510527769 mirMAP;miRNATAP -0.215374190152256 0.00967241936107216 NA NA NA hsa-miR-590-3p FGF9 0.83851360565783 0.00129224433453587 -1.33489997634345 0.0119359510527769 miRanda;mirMAP -0.548375938999422 9.0306963195563e-07 NA NA NA hsa-miR-590-5p FGF9 2.07441240363458 4.95240551694843e-14 -1.33489997634345 0.0119359510527769 miRanda -0.525972441590085 8.17616961503178e-07 NA NA NA hsa-miR-744-3p FGF9 2.07439104592565 3.30645434602132e-12 -1.33489997634345 0.0119359510527769 miRNATAP -0.165734884543851 0.0395089610057569 NA NA NA hsa-miR-9-5p FGF9 4.99250901331516 2.59132733422801e-19 -1.33489997634345 0.0119359510527769 miRNATAP -0.15314002899298 0.000277214145018446 NA NA NA hsa-miR-96-5p FGF9 3.0381097138467 4.40362891630201e-24 -1.33489997634345 0.0119359510527769 TargetScan;miRNATAP -0.211069820905738 0.0186027670930778 NA NA NA hsa-miR-106b-5p FGFR1 1.47447672652218 1.32004094930462e-13 -0.915442355826397 0.000285266909471616 mirMAP -0.142855921259217 0.0128138330092939 NA NA NA hsa-miR-135b-5p FGFR1 3.25019233805845 1.95560099639034e-15 -0.915442355826397 0.000285266909471616 mirMAP -0.141958622178533 1.77794898106879e-06 NA NA NA hsa-miR-15a-5p FGFR1 1.62575353599172 1.55312121019827e-19 -0.915442355826397 0.000285266909471616 miRNATAP -0.243009183557465 0.000100813439112054 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 0.749619098384047 4.11649450706988e-06 -0.915442355826397 0.000285266909471616 miRTarBase;miRNATAP -0.246942745271025 0.000561455743835118 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 2.07078488653279 2.77403038572568e-19 -0.915442355826397 0.000285266909471616 mirMAP -0.159812129963503 0.00102342937863635 NA NA NA hsa-miR-181b-5p FGFR1 0.668793269169928 0.000239998092406404 -0.915442355826397 0.000285266909471616 miRNAWalker2_validate -0.349477340528312 3.64168342971559e-08 NA NA NA hsa-miR-200a-5p FGFR1 2.26680634475411 1.52168554660094e-17 -0.915442355826397 0.000285266909471616 mirMAP -0.200300874512705 1.91408016005907e-06 NA NA NA hsa-miR-200b-5p FGFR1 0.5652412449293 0.0273948420835934 -0.915442355826397 0.000285266909471616 mirMAP -0.138058985825778 0.00247827404178829 NA NA NA hsa-miR-20a-5p FGFR1 2.64649625616975 5.1469418982085e-27 -0.915442355826397 0.000285266909471616 mirMAP -0.173284530375537 0.000105694699814125 NA NA NA hsa-miR-335-3p FGFR1 1.51116383169018 6.88553098788624e-13 -0.915442355826397 0.000285266909471616 mirMAP -0.240186682957272 8.57963673654244e-06 NA NA NA hsa-miR-590-3p FGFR1 0.83851360565783 0.00129224433453587 -0.915442355826397 0.000285266909471616 miRanda;mirMAP -0.108257360531163 0.044097861045077 NA NA NA hsa-miR-93-5p FGFR1 1.50844106515467 1.83836866996875e-12 -0.915442355826397 0.000285266909471616 mirMAP -0.120894165934505 0.0238606535942142 NA NA NA hsa-miR-146b-5p FGFR2 1.0922867893808 5.63754607494775e-06 -2.39472329620768 3.80959748314848e-11 miRanda -0.184601550928346 0.00873114443578221 NA NA NA hsa-miR-186-5p FGFR2 0.852175445703945 6.88885738584309e-10 -2.39472329620768 3.80959748314848e-11 miRNAWalker2_validate -0.244416512292592 0.0472067943979448 NA NA NA hsa-miR-19b-1-5p FGFR2 1.71217036351784 3.28561659177495e-12 -2.39472329620768 3.80959748314848e-11 miRNAWalker2_validate;miRTarBase -0.268412662161793 0.000607501041413817 NA NA NA hsa-miR-324-5p FGFR2 1.06955541886548 5.39722006604758e-05 -2.39472329620768 3.80959748314848e-11 miRanda -0.145174678745676 0.0234836540207274 NA NA NA hsa-miR-542-3p FGFR2 1.62226640768239 2.6427102465476e-10 -2.39472329620768 3.80959748314848e-11 miRanda -0.190402208837821 0.00349409803579517 NA NA NA hsa-miR-590-3p FGFR2 0.83851360565783 0.00129224433453587 -2.39472329620768 3.80959748314848e-11 miRanda -0.383675956139752 7.77181884190165e-07 NA NA NA hsa-miR-142-3p FGFR3 3.98476449801341 1.56256182021111e-35 -1.12699077326621 0.0142487904494546 miRanda -0.224351946350102 0.000237439121756567 NA NA NA hsa-miR-590-3p FGFR3 0.83851360565783 0.00129224433453587 -1.12699077326621 0.0142487904494546 miRanda -0.241166547474611 0.0134697998706565 NA NA NA hsa-miR-106b-5p FLT1 1.47447672652218 1.32004094930462e-13 -0.853716821222124 3.80935455614656e-05 MirTarget;miRNATAP -0.15196065631928 0.00125967239975962 NA NA NA hsa-miR-142-3p FLT1 3.98476449801341 1.56256182021111e-35 -0.853716821222124 3.80935455614656e-05 miRanda;miRNATAP -0.112934202558696 4.26649818225612e-05 NA NA NA hsa-miR-146b-5p FLT1 1.0922867893808 5.63754607494775e-06 -0.853716821222124 3.80935455614656e-05 miRanda -0.132297507944522 0.000831653018892319 NA NA NA hsa-miR-155-5p FLT1 0.813513839059142 0.000608282725633232 -0.853716821222124 3.80935455614656e-05 miRNAWalker2_validate;mirMAP -0.128527734958511 0.00144749151618481 NA NA NA hsa-miR-17-5p FLT1 2.07078488653279 2.77403038572568e-19 -0.853716821222124 3.80935455614656e-05 MirTarget;TargetScan;miRNATAP -0.135735585570969 0.000695574954147908 NA NA NA hsa-miR-181a-5p FLT1 -0.375429731222937 0.0562142867129802 -0.853716821222124 3.80935455614656e-05 miRNATAP -0.13719850761158 0.00522108723394579 NA NA NA hsa-miR-181b-5p FLT1 0.668793269169928 0.000239998092406404 -0.853716821222124 3.80935455614656e-05 miRNATAP -0.228091988878886 1.41100029468761e-05 NA NA NA hsa-miR-186-5p FLT1 0.852175445703945 6.88885738584309e-10 -0.853716821222124 3.80935455614656e-05 mirMAP -0.319611792696536 3.3593313940787e-06 NA NA NA hsa-miR-19b-3p FLT1 2.10868505662119 5.40846613768389e-17 -0.853716821222124 3.80935455614656e-05 MirTarget -0.129753240316954 0.000840150021747134 NA NA NA hsa-miR-200b-3p FLT1 1.55157578247391 4.83790020897188e-09 -0.853716821222124 3.80935455614656e-05 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.149137497361126 2.67044497229278e-05 21115742 Forced miR-200 expression suppressed Flt1 levels in metastasis-prone lung adenocarcinoma cells derived from K-ras/p53-mutant mice and negatively regulated the Flt1 3'-UTR in reporter assays; We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1 metastasis;tumorigenesis lung cancer hsa-miR-200c-3p FLT1 0.380533388300368 0.0842181838538353 -0.853716821222124 3.80935455614656e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.101191029110903 0.0209215160433687 NA NA NA hsa-miR-20a-5p FLT1 2.64649625616975 5.1469418982085e-27 -0.853716821222124 3.80935455614656e-05 MirTarget;miRNATAP -0.145399235210941 7.64688683215748e-05 NA NA NA hsa-miR-28-5p FLT1 1.19639196514745 4.59365801666536e-18 -0.853716821222124 3.80935455614656e-05 miRanda -0.187009123738962 0.00591707421229706 NA NA NA hsa-miR-29a-5p FLT1 1.89519956688438 1.03453349363915e-11 -0.853716821222124 3.80935455614656e-05 MirTarget -0.175417658210396 1.24014458232337e-05 NA NA NA hsa-miR-339-5p FLT1 0.536997313601114 0.0488090394176611 -0.853716821222124 3.80935455614656e-05 miRanda -0.139246508572304 7.36899128620129e-05 NA NA NA hsa-miR-361-5p FLT1 0.21454431962475 0.0800957579368424 -0.853716821222124 3.80935455614656e-05 miRanda -0.241986249183725 0.00246609230162922 NA NA NA hsa-miR-429 FLT1 2.3794516574089 1.72813419703734e-13 -0.853716821222124 3.80935455614656e-05 MirTarget;miRanda;miRNATAP -0.190194777628028 7.66169417536964e-10 NA NA NA hsa-miR-501-5p FLT1 0.411357595674671 0.10435288464149 -0.853716821222124 3.80935455614656e-05 mirMAP -0.140670170116836 0.000205354183101303 NA NA NA hsa-miR-505-5p FLT1 0.77207328399883 0.00479562389564013 -0.853716821222124 3.80935455614656e-05 MirTarget -0.142598381971651 4.34386719692121e-05 NA NA NA hsa-miR-576-5p FLT1 1.02693643167056 1.14846964470173e-06 -0.853716821222124 3.80935455614656e-05 mirMAP -0.115531817875631 0.0106529721016018 NA NA NA hsa-miR-590-3p FLT1 0.83851360565783 0.00129224433453587 -0.853716821222124 3.80935455614656e-05 miRanda -0.142772954752402 0.00120378252750183 NA NA NA hsa-miR-664a-5p FLT1 -0.0936480603578111 0.662274905077117 -0.853716821222124 3.80935455614656e-05 MirTarget -0.204555059118557 8.75678517451646e-06 NA NA NA hsa-miR-93-5p FLT1 1.50844106515467 1.83836866996875e-12 -0.853716821222124 3.80935455614656e-05 MirTarget;miRNATAP -0.199814602709946 4.71374653185103e-06 NA NA NA hsa-miR-542-3p FLT3 1.62226640768239 2.6427102465476e-10 -1.00556785809288 0.00338224604235755 miRanda -0.160784295906754 0.00804059626624641 NA NA NA hsa-miR-429 FLT4 2.3794516574089 1.72813419703734e-13 -1.56395694632575 7.75833948395905e-12 miRanda;miRNATAP -0.218735391764706 2.59527657323593e-10 NA NA NA hsa-miR-96-5p FOXO4 3.0381097138467 4.40362891630201e-24 -0.921940446528887 1.65116449334641e-10 MirTarget;TargetScan;miRNATAP -0.118170706575055 1.43096967487931e-06 NA NA NA hsa-miR-106a-5p GAB1 1.3902608059488 6.07931522284525e-05 -1.50528473981495 8.66146223452754e-20 MirTarget;miRNATAP -0.107044044344625 2.23693062945224e-05 NA NA NA hsa-miR-106b-5p GAB1 1.47447672652218 1.32004094930462e-13 -1.50528473981495 8.66146223452754e-20 MirTarget;miRNATAP -0.213305787308601 2.91725467155583e-08 NA NA NA hsa-miR-141-3p GAB1 3.36993755486106 5.42939251147195e-32 -1.50528473981495 8.66146223452754e-20 MirTarget;TargetScan -0.193331111252096 1.44567939206299e-14 NA NA NA hsa-miR-141-5p GAB1 3.02575703771074 1.54385222591327e-32 -1.50528473981495 8.66146223452754e-20 MirTarget -0.201668414467571 1.15936061385581e-12 NA NA NA hsa-miR-142-3p GAB1 3.98476449801341 1.56256182021111e-35 -1.50528473981495 8.66146223452754e-20 MirTarget;PITA;miRanda;miRNATAP -0.153155017646252 8.24170213686319e-12 NA NA NA hsa-miR-15b-3p GAB1 0.804736041893915 0.000400279611457186 -1.50528473981495 8.66146223452754e-20 mirMAP -0.11181261811506 0.00230577976468825 NA NA NA hsa-miR-16-1-3p GAB1 1.50034693398929 6.63958242991125e-10 -1.50528473981495 8.66146223452754e-20 mirMAP -0.102021936037913 0.0106578557524156 NA NA NA hsa-miR-17-5p GAB1 2.07078488653279 2.77403038572568e-19 -1.50528473981495 8.66146223452754e-20 MirTarget;TargetScan;miRNATAP -0.245843056576296 2.33212787633372e-14 NA NA NA hsa-miR-181d-5p GAB1 1.19058140522592 8.5908558852417e-09 -1.50528473981495 8.66146223452754e-20 miRNAWalker2_validate -0.10936366404994 0.00389136093843163 NA NA NA hsa-miR-186-5p GAB1 0.852175445703945 6.88885738584309e-10 -1.50528473981495 8.66146223452754e-20 mirMAP -0.185848709776328 0.00112911354360173 NA NA NA hsa-miR-18a-5p GAB1 1.37435209536521 9.2173853686829e-06 -1.50528473981495 8.66146223452754e-20 MirTarget;miRNATAP -0.190457035167762 1.46147054108952e-12 NA NA NA hsa-miR-200a-3p GAB1 3.14766878548496 1.32850889777422e-21 -1.50528473981495 8.66146223452754e-20 MirTarget -0.119765991799109 2.80538857728097e-07 NA NA NA hsa-miR-20a-5p GAB1 2.64649625616975 5.1469418982085e-27 -1.50528473981495 8.66146223452754e-20 MirTarget;miRNATAP -0.214172947368733 6.12948735287046e-13 NA NA NA hsa-miR-212-3p GAB1 0.404496907089793 0.103551762277891 -1.50528473981495 8.66146223452754e-20 mirMAP -0.112627719476236 0.000414180308378115 NA NA NA hsa-miR-29b-1-5p GAB1 1.71024742617744 3.64915691793611e-09 -1.50528473981495 8.66146223452754e-20 mirMAP -0.163566722118512 6.47071022572862e-10 NA NA NA hsa-miR-29b-3p GAB1 3.10527711861309 3.01242507282711e-32 -1.50528473981495 8.66146223452754e-20 MirTarget -0.198807550447738 4.78223295088776e-13 NA NA NA hsa-miR-335-3p GAB1 1.51116383169018 6.88553098788624e-13 -1.50528473981495 8.66146223452754e-20 mirMAP -0.181045911135404 7.28405027461665e-07 NA NA NA hsa-miR-429 GAB1 2.3794516574089 1.72813419703734e-13 -1.50528473981495 8.66146223452754e-20 miRanda;miRNATAP -0.102016731588578 7.74090656125421e-05 NA NA NA hsa-miR-590-3p GAB1 0.83851360565783 0.00129224433453587 -1.50528473981495 8.66146223452754e-20 miRanda;mirMAP -0.132162764947127 0.000274666897887478 NA NA NA hsa-miR-7-1-3p GAB1 2.61364240402652 1.98959237815786e-32 -1.50528473981495 8.66146223452754e-20 mirMAP -0.252850004040143 2.60795548912408e-13 NA NA NA hsa-miR-93-5p GAB1 1.50844106515467 1.83836866996875e-12 -1.50528473981495 8.66146223452754e-20 MirTarget;miRNATAP -0.217276255813447 1.17336958075135e-09 NA NA NA hsa-miR-199b-5p GAB2 2.13822205171062 4.56262988762436e-15 -1.26415231594586 2.30483749340941e-11 mirMAP -0.129657839601799 3.82962520014587e-05 NA NA NA hsa-miR-452-3p GAB2 0.477736876273128 0.22218404598603 -1.26415231594586 2.30483749340941e-11 mirMAP -0.104446847121871 7.31601807890106e-05 NA NA NA hsa-miR-590-3p GAB2 0.83851360565783 0.00129224433453587 -1.26415231594586 2.30483749340941e-11 PITA;miRanda -0.128027608618981 0.00171132417970706 NA NA NA hsa-miR-194-5p GLCCI1 1.76979641760284 8.2064222072696e-05 -0.353989495128635 0.138583225687492 MirTarget -0.135954932208857 1.37289259575922e-08 NA NA NA hsa-miR-103a-3p GNB1 0.538497806383155 1.88134691850591e-05 -0.113359179439685 0.195982693610462 miRNAWalker2_validate -0.117501466818173 0.000245189860341104 NA NA NA hsa-miR-455-5p GNB1 1.36946341828134 5.05118627562807e-08 -0.113359179439685 0.195982693610462 miRanda -0.108101477167502 1.61497275462324e-09 NA NA NA hsa-miR-30b-3p GNB3 -1.20976737190106 2.63726511331003e-06 1.69073826499078 7.74067547508589e-08 MirTarget -0.179197209145642 0.00153276442471823 NA NA NA hsa-miR-21-5p GNB4 4.38165933891779 1.52536633902505e-92 -0.773241223004692 8.02059608334668e-05 miRNAWalker2_validate -0.107864200716027 0.00179440282483582 NA NA NA hsa-miR-27b-3p GNB4 0.236438984240408 0.12263510345883 -0.773241223004692 8.02059608334668e-05 miRNAWalker2_validate -0.210879510550501 0.000426209888920114 NA NA NA hsa-miR-29a-3p GNB4 0.101650412194573 0.573201097011668 -0.773241223004692 8.02059608334668e-05 MirTarget -0.168333381395 0.000894636314361531 NA NA NA hsa-miR-29b-3p GNB4 3.10527711861309 3.01242507282711e-32 -0.773241223004692 8.02059608334668e-05 MirTarget -0.189703366062938 2.34684961828285e-09 NA NA NA hsa-miR-3065-5p GNB4 0.653308707552535 0.0999497219778851 -0.773241223004692 8.02059608334668e-05 mirMAP -0.121122292313831 8.89741281675571e-07 NA NA NA hsa-miR-429 GNB4 2.3794516574089 1.72813419703734e-13 -0.773241223004692 8.02059608334668e-05 miRanda -0.240268760697607 6.09768937468449e-17 NA NA NA hsa-miR-501-5p GNB4 0.411357595674671 0.10435288464149 -0.773241223004692 8.02059608334668e-05 mirMAP -0.113445591286251 0.001569081902348 NA NA NA hsa-miR-93-5p GNB4 1.50844106515467 1.83836866996875e-12 -0.773241223004692 8.02059608334668e-05 miRNAWalker2_validate -0.116932524718652 0.00488189460124817 NA NA NA hsa-miR-96-5p GNB4 3.0381097138467 4.40362891630201e-24 -0.773241223004692 8.02059608334668e-05 MirTarget -0.251282720636843 6.94534802266421e-15 NA NA NA hsa-miR-342-3p GNB5 -0.128691966564961 0.561034080130801 0.195294444380377 0.0983508797090191 miRanda -0.127429687786504 1.6487338390712e-07 NA NA NA hsa-miR-107 GNG12 0.658676029898313 5.11480446318819e-07 -0.481052982891586 0.0106970234636918 miRanda -0.240152271925136 0.000296272815140921 NA NA NA hsa-miR-186-5p GNG12 0.852175445703945 6.88885738584309e-10 -0.481052982891586 0.0106970234636918 miRNAWalker2_validate -0.138598280018889 0.0271185572912279 NA NA NA hsa-miR-590-3p GNG12 0.83851360565783 0.00129224433453587 -0.481052982891586 0.0106970234636918 miRanda;mirMAP -0.106371542166068 0.00772124644373765 NA NA NA hsa-miR-590-5p GNG12 2.07441240363458 4.95240551694843e-14 -0.481052982891586 0.0106970234636918 PITA -0.223723753830493 2.62733560738329e-09 NA NA NA hsa-miR-96-5p GNG12 3.0381097138467 4.40362891630201e-24 -0.481052982891586 0.0106970234636918 TargetScan -0.178457232594575 1.23065278598398e-08 NA NA NA hsa-miR-21-5p GNG2 4.38165933891779 1.52536633902505e-92 -1.07252911873911 1.7090824521982e-08 miRNATAP -0.195454981949984 4.65483751845796e-09 NA NA NA hsa-miR-29b-3p GNG2 3.10527711861309 3.01242507282711e-32 -1.07252911873911 1.7090824521982e-08 miRNATAP -0.142780740359251 5.16429361551287e-06 NA NA NA hsa-miR-324-5p GNG2 1.06955541886548 5.39722006604758e-05 -1.07252911873911 1.7090824521982e-08 miRanda -0.221830150375793 1.13086546193881e-11 NA NA NA hsa-miR-335-3p GNG2 1.51116383169018 6.88553098788624e-13 -1.07252911873911 1.7090824521982e-08 mirMAP -0.240567600489885 3.49917850638484e-09 NA NA NA hsa-miR-429 GNG2 2.3794516574089 1.72813419703734e-13 -1.07252911873911 1.7090824521982e-08 miRanda;miRNATAP -0.204223932362233 6.14680056882904e-13 NA NA NA hsa-miR-500a-5p GNG2 0.648155655714409 0.0104657432932038 -1.07252911873911 1.7090824521982e-08 mirMAP -0.11274419739223 0.00174283911743799 NA NA NA hsa-miR-576-5p GNG2 1.02693643167056 1.14846964470173e-06 -1.07252911873911 1.7090824521982e-08 mirMAP -0.177380920431951 1.97687565002678e-05 NA NA NA hsa-miR-590-5p GNG2 2.07441240363458 4.95240551694843e-14 -1.07252911873911 1.7090824521982e-08 miRanda;miRNATAP -0.245120778111592 1.60106027155252e-10 NA NA NA hsa-miR-181a-2-3p GNG4 -0.0760679893470186 0.687414621472156 1.72312254651559 0.00587807376629479 MirTarget -0.521848705759067 0.000687313416764603 NA NA NA hsa-miR-200a-3p GNG4 3.14766878548496 1.32850889777422e-21 1.72312254651559 0.00587807376629479 mirMAP -0.170478040074369 0.0474706057680221 NA NA NA hsa-miR-200b-3p GNG4 1.55157578247391 4.83790020897188e-09 1.72312254651559 0.00587807376629479 mirMAP -0.306715881883784 0.00426489766083202 NA NA NA hsa-miR-203a-3p GNG4 1.06866854356847 0.00389979689199624 1.72312254651559 0.00587807376629479 MirTarget -0.259839165085709 0.000811028160640383 NA NA NA hsa-miR-23b-3p GNG4 -0.070273068040148 0.620585267977425 1.72312254651559 0.00587807376629479 mirMAP -0.419933217632151 0.04264383471599 NA NA NA hsa-miR-3065-5p GNG4 0.653308707552535 0.0999497219778851 1.72312254651559 0.00587807376629479 mirMAP -0.432702216687085 3.08252945104106e-08 NA NA NA hsa-miR-338-3p GNG4 0.726843067232002 0.0506251324215494 1.72312254651559 0.00587807376629479 miRanda -0.493337283401031 9.46534696968155e-11 NA NA NA hsa-miR-452-5p GNG4 0.637123950346362 0.0458173998136196 1.72312254651559 0.00587807376629479 mirMAP -0.292531418034242 0.00120833949138994 NA NA NA hsa-miR-141-3p GNG7 3.36993755486106 5.42939251147195e-32 -1.41246014447214 2.13793630570999e-07 MirTarget;TargetScan;miRNATAP -0.189167674111421 4.10841385093332e-06 NA NA NA hsa-miR-17-3p GNG7 1.36706429551147 4.60388403547821e-13 -1.41246014447214 2.13793630570999e-07 mirMAP -0.374874020476443 8.0369641742108e-09 NA NA NA hsa-miR-182-5p GNG7 3.21839823004635 5.13049145201115e-39 -1.41246014447214 2.13793630570999e-07 mirMAP -0.19361001460947 3.99850320331774e-05 NA NA NA hsa-miR-185-3p GNG7 -0.377490365509078 0.093653288903368 -1.41246014447214 2.13793630570999e-07 mirMAP -0.293431565357679 1.60460735745411e-07 NA NA NA hsa-miR-18a-5p GNG7 1.37435209536521 9.2173853686829e-06 -1.41246014447214 2.13793630570999e-07 mirMAP -0.357133892265359 5.57343004386596e-17 NA NA NA hsa-miR-193b-5p GNG7 0.179695858885499 0.55521472494233 -1.41246014447214 2.13793630570999e-07 mirMAP -0.135144229514802 0.00120517117584307 NA NA NA hsa-miR-22-5p GNG7 1.71436244278242 9.85038001236064e-15 -1.41246014447214 2.13793630570999e-07 mirMAP -0.118777185055953 0.0336972904085861 NA NA NA hsa-miR-3127-5p GNG7 0.382717393698386 0.11535780874721 -1.41246014447214 2.13793630570999e-07 mirMAP -0.141400895796466 0.00695830869520311 NA NA NA hsa-miR-330-5p GNG7 0.168520831101569 0.336433937906706 -1.41246014447214 2.13793630570999e-07 mirMAP -0.157915532660133 0.0310071985646167 NA NA NA hsa-miR-3615 GNG7 -0.920757770068656 0.000115639731296878 -1.41246014447214 2.13793630570999e-07 mirMAP -0.106020930820396 0.045759929753161 NA NA NA hsa-miR-590-3p GNG7 0.83851360565783 0.00129224433453587 -1.41246014447214 2.13793630570999e-07 PITA;miRanda;mirMAP -0.22363480187195 0.000119744484254228 NA NA NA hsa-miR-671-5p GNG7 2.24156654191798 2.10433241567652e-14 -1.41246014447214 2.13793630570999e-07 mirMAP -0.24848614597746 6.35445092234873e-07 NA NA NA hsa-miR-766-3p GNG7 0.0784037775118556 0.760091599198293 -1.41246014447214 2.13793630570999e-07 MirTarget -0.160873184528654 0.00116612286541079 NA NA NA hsa-miR-9-5p GNG7 4.99250901331516 2.59132733422801e-19 -1.41246014447214 2.13793630570999e-07 mirMAP -0.155921330432605 2.93551118394192e-13 NA NA NA hsa-miR-92a-3p GNG7 -0.136362762339122 0.493412263619364 -1.41246014447214 2.13793630570999e-07 miRNAWalker2_validate -0.230320816939184 0.000321658197767431 NA NA NA hsa-miR-940 GNG7 0.011138136211269 0.974925352379525 -1.41246014447214 2.13793630570999e-07 MirTarget -0.184899914783095 3.81240270334476e-06 NA NA NA hsa-miR-96-5p GNG7 3.0381097138467 4.40362891630201e-24 -1.41246014447214 2.13793630570999e-07 mirMAP -0.21085275506079 4.76896318898963e-06 NA NA NA hsa-miR-219a-1-3p GNGT2 0.42818839093396 0.0892433909993089 -1.32163682528978 7.3757518477017e-09 MirTarget -0.171342381827645 8.34792017996791e-05 NA NA NA hsa-miR-330-5p GNGT2 0.168520831101569 0.336433937906706 -1.32163682528978 7.3757518477017e-09 miRanda -0.131598250393007 0.0327798202717152 NA NA NA hsa-miR-27b-3p GRB2 0.236438984240408 0.12263510345883 -0.210706496557246 0.0100478898753454 MirTarget;miRNATAP -0.113414213940692 3.83461454675988e-06 NA NA NA hsa-miR-30c-2-3p GRIN1 -3.10905250533941 6.84550165664783e-27 2.42626680854531 1.68015354994705e-07 mirMAP -0.475184622862362 5.96600162426825e-12 NA NA NA hsa-miR-3614-5p GRIN1 -1.19394699210224 2.53933783780868e-05 2.42626680854531 1.68015354994705e-07 mirMAP -0.414619053097061 3.309641132728e-08 NA NA NA hsa-miR-423-5p GRIN1 -1.80309342242719 1.34791344187441e-19 2.42626680854531 1.68015354994705e-07 miRNATAP -0.290837565730237 0.00552210555231763 NA NA NA hsa-miR-107 GRIN2A 0.658676029898313 5.11480446318819e-07 -1.28464390099752 0.0340136533276402 miRanda -0.764710541108039 0.000342457067580046 NA NA NA hsa-miR-130b-5p GRIN2A 1.53645187062942 1.10498816261505e-08 -1.28464390099752 0.0340136533276402 mirMAP -0.570074947684426 1.72478817393232e-08 NA NA NA hsa-miR-148b-5p GRIN2A 1.39335695292409 2.13220380550073e-07 -1.28464390099752 0.0340136533276402 mirMAP -0.662724700609609 5.76396637444165e-08 NA NA NA hsa-miR-15b-3p GRIN2A 0.804736041893915 0.000400279611457186 -1.28464390099752 0.0340136533276402 mirMAP -0.650170837992626 3.93278971095323e-07 NA NA NA hsa-miR-182-5p GRIN2A 3.21839823004635 5.13049145201115e-39 -1.28464390099752 0.0340136533276402 mirMAP -0.229361753557847 0.0280143730122227 NA NA NA hsa-miR-186-5p GRIN2A 0.852175445703945 6.88885738584309e-10 -1.28464390099752 0.0340136533276402 mirMAP -0.781966816587457 9.7568624409021e-05 NA NA NA hsa-miR-25-3p GRIN2A 0.361927330834176 0.0163670566170988 -1.28464390099752 0.0340136533276402 mirMAP -0.944213760962241 3.58746157958185e-07 NA NA NA hsa-miR-29a-5p GRIN2A 1.89519956688438 1.03453349363915e-11 -1.28464390099752 0.0340136533276402 mirMAP -0.249389139793867 0.0340134456688623 NA NA NA hsa-miR-320b GRIN2A 0.226640952564488 0.378818692487242 -1.28464390099752 0.0340136533276402 PITA -0.226030682080858 0.0381496514758557 NA NA NA hsa-miR-335-3p GRIN2A 1.51116383169018 6.88553098788624e-13 -1.28464390099752 0.0340136533276402 mirMAP -0.512218267561324 7.57469410400899e-05 NA NA NA hsa-miR-590-3p GRIN2A 0.83851360565783 0.00129224433453587 -1.28464390099752 0.0340136533276402 miRanda;mirMAP -0.734710241895757 6.60867994280957e-09 NA NA NA hsa-miR-590-5p GRIN2A 2.07441240363458 4.95240551694843e-14 -1.28464390099752 0.0340136533276402 miRanda -0.803306302780922 2.45155299232081e-11 NA NA NA hsa-miR-629-5p GRIN2A 1.31657090341737 1.45711558652127e-12 -1.28464390099752 0.0340136533276402 mirMAP -0.910929160055992 3.34908952994404e-10 NA NA NA hsa-miR-7-1-3p GRIN2A 2.61364240402652 1.98959237815786e-32 -1.28464390099752 0.0340136533276402 mirMAP -0.587241278946426 2.13224417816308e-06 NA NA NA hsa-miR-877-5p GRIN2A -0.370234513208225 0.20670834111988 -1.28464390099752 0.0340136533276402 mirMAP -0.402201653380328 2.40205209030081e-05 NA NA NA hsa-miR-92a-3p GRIN2A -0.136362762339122 0.493412263619364 -1.28464390099752 0.0340136533276402 mirMAP -0.568953869301679 5.22284742040312e-05 NA NA NA hsa-let-7a-3p HGF 0.167285443861993 0.431834813181487 -1.46782534168535 1.69011867186688e-05 mirMAP -0.220233871328952 0.00866054421617636 NA NA NA hsa-let-7f-1-3p HGF -0.0921261289038979 0.693970843315065 -1.46782534168535 1.69011867186688e-05 mirMAP -0.210155083903482 0.0131583763412536 NA NA NA hsa-miR-141-3p HGF 3.36993755486106 5.42939251147195e-32 -1.46782534168535 1.69011867186688e-05 MirTarget;TargetScan -0.400868595787034 1.23049606342836e-15 NA NA NA hsa-miR-200a-3p HGF 3.14766878548496 1.32850889777422e-21 -1.46782534168535 1.69011867186688e-05 MirTarget -0.253494768373625 5.0583757364239e-08 NA NA NA hsa-miR-203a-3p HGF 1.06866854356847 0.00389979689199624 -1.46782534168535 1.69011867186688e-05 MirTarget -0.153601511229596 0.000301513481806427 NA NA NA hsa-miR-26b-5p HGF 0.72362441215247 4.7794659748036e-05 -1.46782534168535 1.69011867186688e-05 MirTarget;miRNATAP -0.305370801964651 0.000589397366341262 NA NA NA hsa-miR-29a-5p HGF 1.89519956688438 1.03453349363915e-11 -1.46782534168535 1.69011867186688e-05 mirMAP -0.289655913024973 1.20483934738604e-05 NA NA NA hsa-miR-30b-5p HGF 0.358144314839612 0.138026229059594 -1.46782534168535 1.69011867186688e-05 mirMAP -0.228949192247152 0.000487341920331379 NA NA NA hsa-miR-335-3p HGF 1.51116383169018 6.88553098788624e-13 -1.46782534168535 1.69011867186688e-05 mirMAP -0.181311076961739 0.013971046838092 NA NA NA hsa-miR-421 HGF 0.170525317701774 0.535277026680289 -1.46782534168535 1.69011867186688e-05 miRanda -0.191831411356542 0.00221575379454529 NA NA NA hsa-miR-429 HGF 2.3794516574089 1.72813419703734e-13 -1.46782534168535 1.69011867186688e-05 miRanda -0.328662037767097 1.0453775228151e-10 NA NA NA hsa-miR-542-3p HGF 1.62226640768239 2.6427102465476e-10 -1.46782534168535 1.69011867186688e-05 miRanda -0.190590602252299 0.00164459151192755 NA NA NA hsa-miR-590-3p HGF 0.83851360565783 0.00129224433453587 -1.46782534168535 1.69011867186688e-05 miRanda;mirMAP -0.347975466531176 1.44513714212125e-06 NA NA NA hsa-miR-590-5p HGF 2.07441240363458 4.95240551694843e-14 -1.46782534168535 1.69011867186688e-05 miRanda -0.408173134036666 2.61219989107118e-09 NA NA NA hsa-miR-651-5p HGF 1.67013048675395 1.61458229225137e-07 -1.46782534168535 1.69011867186688e-05 MirTarget -0.277915118196018 4.80995997083731e-06 NA NA NA hsa-miR-7-1-3p HGF 2.61364240402652 1.98959237815786e-32 -1.46782534168535 1.69011867186688e-05 mirMAP -0.28714079677471 4.59341965745208e-05 NA NA NA hsa-let-7a-5p HRAS -1.37014061604018 3.11451492971224e-14 0.139800610267073 0.358123351398595 miRNAWalker2_validate;miRTarBase -0.142144334211175 0.000164893588817854 18344688;20033209;20607356;23134218;19323605 Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;;progression lung cancer;lung cancer;glioblastoma;lung squamous cell cancer;pancreatic cancer hsa-miR-143-3p HRAS -1.21021691908494 5.70938667332876e-06 0.139800610267073 0.358123351398595 miRNAWalker2_validate;miRTarBase -0.125376896055055 1.11873626270013e-06 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-29b-3p HTR7 3.10527711861309 3.01242507282711e-32 -0.385718491303667 0.215236468815232 miRNATAP -0.126553910961755 0.0128995987781426 NA NA NA hsa-miR-324-5p HTR7 1.06955541886548 5.39722006604758e-05 -0.385718491303667 0.215236468815232 miRanda -0.224277908672383 2.7449879911002e-05 NA NA NA hsa-miR-375 HTR7 0.615547997686534 0.149199273675144 -0.385718491303667 0.215236468815232 miRanda -0.220119673848679 2.11770039728668e-11 NA NA NA hsa-miR-130a-3p IGF1 0.881660100597014 0.000158893668519248 -0.878839289406132 0.00545024687919024 MirTarget -0.137360175720236 0.0278198372780902 NA NA NA hsa-miR-130b-3p IGF1 1.83046548750752 5.04753914574694e-13 -0.878839289406132 0.00545024687919024 MirTarget -0.208984208427567 0.000411905460472152 NA NA NA hsa-miR-15b-3p IGF1 0.804736041893915 0.000400279611457186 -0.878839289406132 0.00545024687919024 mirMAP -0.294250039955051 1.19648006053704e-05 NA NA NA hsa-miR-16-1-3p IGF1 1.50034693398929 6.63958242991125e-10 -0.878839289406132 0.00545024687919024 mirMAP -0.346697103874593 2.00512825999278e-06 NA NA NA hsa-miR-181b-5p IGF1 0.668793269169928 0.000239998092406404 -0.878839289406132 0.00545024687919024 mirMAP -0.277079678771502 0.000542842928980559 NA NA NA hsa-miR-186-5p IGF1 0.852175445703945 6.88885738584309e-10 -0.878839289406132 0.00545024687919024 mirMAP -0.579822063247168 2.4486690275545e-08 NA NA NA hsa-miR-19a-3p IGF1 2.11776595911517 7.07663078397156e-10 -0.878839289406132 0.00545024687919024 MirTarget -0.295619339516778 1.77416468047122e-09 NA NA NA hsa-miR-19b-1-5p IGF1 1.71217036351784 3.28561659177495e-12 -0.878839289406132 0.00545024687919024 mirMAP -0.353413690663535 1.05429610809513e-07 NA NA NA hsa-miR-19b-3p IGF1 2.10868505662119 5.40846613768389e-17 -0.878839289406132 0.00545024687919024 MirTarget -0.332913498199372 1.17742302735622e-08 NA NA NA hsa-miR-20a-3p IGF1 2.51803599558247 4.92479325298629e-13 -0.878839289406132 0.00545024687919024 mirMAP -0.27191171788815 1.96054552687628e-07 NA NA NA hsa-miR-26b-5p IGF1 0.72362441215247 4.7794659748036e-05 -0.878839289406132 0.00545024687919024 mirMAP -0.268812581966602 0.00103479699566484 NA NA NA hsa-miR-29b-3p IGF1 3.10527711861309 3.01242507282711e-32 -0.878839289406132 0.00545024687919024 MirTarget -0.214642092755044 3.159014552534e-05 25592039 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 IGF1 3' untranslated region 3'UTR; IGF1 an activator of PI3K/Akt signaling was confirmed as a novel target of miR-29b colorectal cancer hsa-miR-301a-3p IGF1 2.70198002906399 1.56420889710984e-14 -0.878839289406132 0.00545024687919024 MirTarget -0.262923939050952 1.05879075346237e-07 NA NA NA hsa-miR-3065-5p IGF1 0.653308707552535 0.0999497219778851 -0.878839289406132 0.00545024687919024 mirMAP -0.125233094164205 0.00171064732391524 NA NA NA hsa-miR-361-5p IGF1 0.21454431962475 0.0800957579368424 -0.878839289406132 0.00545024687919024 PITA;mirMAP -0.259580395383156 0.0330038273746438 NA NA NA hsa-miR-362-5p IGF1 0.658947634569393 0.0243306847205756 -0.878839289406132 0.00545024687919024 mirMAP -0.262372836237127 2.21880393042342e-07 NA NA NA hsa-miR-421 IGF1 0.170525317701774 0.535277026680289 -0.878839289406132 0.00545024687919024 PITA -0.124950123530714 0.0309856829172305 NA NA NA hsa-miR-450b-5p IGF1 1.69248953402469 1.96052058003353e-07 -0.878839289406132 0.00545024687919024 MirTarget;PITA;mirMAP;miRNATAP -0.155478745947113 0.00168638246971297 NA NA NA hsa-miR-454-3p IGF1 1.49453641052169 4.46235742871434e-09 -0.878839289406132 0.00545024687919024 MirTarget -0.353703568576877 1.23901415685651e-07 NA NA NA hsa-miR-576-5p IGF1 1.02693643167056 1.14846964470173e-06 -0.878839289406132 0.00545024687919024 PITA;mirMAP;miRNATAP -0.319877018116458 2.70279102064343e-06 NA NA NA hsa-miR-590-3p IGF1 0.83851360565783 0.00129224433453587 -0.878839289406132 0.00545024687919024 MirTarget;miRanda;mirMAP;miRNATAP -0.218208367579052 0.00112544995000528 NA NA NA hsa-miR-629-5p IGF1 1.31657090341737 1.45711558652127e-12 -0.878839289406132 0.00545024687919024 mirMAP -0.206791424784461 0.0072984659842286 NA NA NA hsa-let-7i-5p IGF1R 0.605080599172936 1.48406814653206e-06 -0.178629243747184 0.436534266278541 MirTarget;miRNATAP -0.256694243116189 0.00240085762971046 NA NA NA hsa-miR-146b-5p IGF1R 1.0922867893808 5.63754607494775e-06 -0.178629243747184 0.436534266278541 miRanda -0.303094486796453 1.088821796606e-12 NA NA NA hsa-miR-148a-5p IGF1R 1.45633512586855 1.81792463521257e-08 -0.178629243747184 0.436534266278541 mirMAP -0.119635539017428 0.00292895606929232 NA NA NA hsa-miR-150-5p IGF1R -0.702328520623782 0.0215316651134431 -0.178629243747184 0.436534266278541 mirMAP -0.143209266356849 3.01493577213741e-05 NA NA NA hsa-miR-155-5p IGF1R 0.813513839059142 0.000608282725633232 -0.178629243747184 0.436534266278541 mirMAP -0.268968974534585 7.32602920272678e-10 NA NA NA hsa-miR-15a-5p IGF1R 1.62575353599172 1.55312121019827e-19 -0.178629243747184 0.436534266278541 miRNATAP -0.193944653970012 0.000607738723136944 NA NA NA hsa-miR-16-1-3p IGF1R 1.50034693398929 6.63958242991125e-10 -0.178629243747184 0.436534266278541 mirMAP -0.194764020480667 0.00023684295920273 NA NA NA hsa-miR-16-5p IGF1R 0.749619098384047 4.11649450706988e-06 -0.178629243747184 0.436534266278541 miRNATAP -0.128074947776339 0.0486849278613552 23507142 Furthermore we confirmed that IGF1R is a direct target of miR-16; In clinical specimens IGF1R levels inversely correlate with miR-16 expression; Our results provide significant clues regarding the role of miR-16 as a tumor suppressor by targeting IGF1R in OS sarcoma hsa-miR-181b-5p IGF1R 0.668793269169928 0.000239998092406404 -0.178629243747184 0.436534266278541 miRNAWalker2_validate -0.118269259920407 0.0419629264135912 NA NA NA hsa-miR-29b-1-5p IGF1R 1.71024742617744 3.64915691793611e-09 -0.178629243747184 0.436534266278541 mirMAP -0.109156019731015 0.00228581523963077 NA NA NA hsa-miR-342-3p IGF1R -0.128691966564961 0.561034080130801 -0.178629243747184 0.436534266278541 mirMAP -0.218844007083102 4.21137505967977e-06 NA NA NA hsa-miR-342-5p IGF1R -0.382174669348421 0.0896996965047193 -0.178629243747184 0.436534266278541 mirMAP -0.133834784601358 0.00441518826245992 NA NA NA hsa-miR-3613-5p IGF1R 0.0237159233591191 0.934730899070298 -0.178629243747184 0.436534266278541 mirMAP;miRNATAP -0.111944367005522 0.0105168503758625 NA NA NA hsa-miR-378a-3p IGF1R -2.0140903990983 1.146745431034e-18 -0.178629243747184 0.436534266278541 miRTarBase;MirTarget;miRNATAP -0.12672222415071 0.00445290085061963 24119742;25427715;24412052 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS; MiR-378a-3p over-expression in an RMS-derived cell line suppressed IGF1R expression and affected phosphorylated-Akt protein levels;Furthermore miR-378a-3p over-expression or down-regulation could inhibit or enhance insulin-like growth factor 1 receptor IGF1R expression in CRC cells; There was a significantly negative correlation between IGF1R protein expression and miR-378a-3p expression in CRC tissues ;; liver cancer;sarcoma;colorectal cancer hsa-miR-378a-5p IGF1R -1.22647878854015 9.72314015412955e-08 -0.178629243747184 0.436534266278541 mirMAP -0.110932774357196 0.0146391090410064 24119742;25427715 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS ; liver cancer;sarcoma hsa-miR-500a-3p IGF1R -0.137335632790721 0.545751862031252 -0.178629243747184 0.436534266278541 mirMAP -0.175210626907922 0.000163434267424394 NA NA NA hsa-miR-532-5p IGF1R 0.576620898517708 0.0023245812680956 -0.178629243747184 0.436534266278541 miRNATAP -0.14810963695722 0.00808068095369003 NA NA NA hsa-miR-141-3p IGF2 3.36993755486106 5.42939251147195e-32 -1.08658013151097 0.0418048512628873 MirTarget;TargetScan -0.284835821692114 0.000367809561255195 NA NA NA hsa-miR-148b-3p IGF2 0.483970528590224 0.0026495409465901 -1.08658013151097 0.0418048512628873 mirMAP -0.390556176396612 0.0112108589399326 NA NA NA hsa-miR-150-5p IGF2 -0.702328520623782 0.0215316651134431 -1.08658013151097 0.0418048512628873 miRNAWalker2_validate -0.236779050056331 0.00323554650957194 NA NA NA hsa-miR-192-5p IGF2 2.03412119423736 1.6357945826287e-05 -1.08658013151097 0.0418048512628873 mirMAP -0.140839590585574 0.00635848251610975 NA NA NA hsa-miR-19a-3p IGF2 2.11776595911517 7.07663078397156e-10 -1.08658013151097 0.0418048512628873 mirMAP -0.168285578499069 0.0457611104668744 NA NA NA hsa-miR-19b-3p IGF2 2.10868505662119 5.40846613768389e-17 -1.08658013151097 0.0418048512628873 mirMAP -0.268219110705068 0.00715823274343047 NA NA NA hsa-miR-335-3p IGF2 1.51116383169018 6.88553098788624e-13 -1.08658013151097 0.0418048512628873 MirTarget -0.313803107897319 0.00612624794698323 NA NA NA hsa-miR-361-3p IGF2 0.0988926195529967 0.549128728500555 -1.08658013151097 0.0418048512628873 mirMAP -0.345434144984159 0.0220834151406691 NA NA NA hsa-miR-93-5p IGF2 1.50844106515467 1.83836866996875e-12 -1.08658013151097 0.0418048512628873 miRNAWalker2_validate -0.232294653357719 0.0394831192458302 NA NA NA hsa-miR-107 IKBKG 0.658676029898313 5.11480446318819e-07 0.0843830838323729 0.544710841322622 miRanda -0.126711425730293 0.00969342977912645 NA NA NA hsa-miR-143-3p IKBKG -1.21021691908494 5.70938667332876e-06 0.0843830838323729 0.544710841322622 mirMAP -0.162693115202678 2.58257152475095e-12 NA NA NA hsa-miR-17-3p IKBKG 1.36706429551147 4.60388403547821e-13 0.0843830838323729 0.544710841322622 mirMAP -0.124943383525099 0.000155383572679206 NA NA NA hsa-miR-24-3p IKBKG -0.0357874587555003 0.785865078836504 0.0843830838323729 0.544710841322622 mirMAP -0.14327021053209 0.00372994900140062 NA NA NA hsa-miR-330-3p IKBKG -0.716924999893351 0.000796236278616087 0.0843830838323729 0.544710841322622 mirMAP -0.174026313241355 3.45303704238481e-09 NA NA NA hsa-let-7i-5p INSR 0.605080599172936 1.48406814653206e-06 0.072568705841749 0.687422001875906 miRNATAP -0.133226845670524 0.0452910838297064 NA NA NA hsa-miR-140-3p INSR -1.11373309124537 8.35257079443689e-14 0.072568705841749 0.687422001875906 mirMAP -0.200969274134693 0.000223788161756352 NA NA NA hsa-miR-142-5p INSR 1.29672439149353 4.0768822158894e-06 0.072568705841749 0.687422001875906 mirMAP -0.128826469755798 4.33606154307156e-05 NA NA NA hsa-miR-15a-5p INSR 1.62575353599172 1.55312121019827e-19 0.072568705841749 0.687422001875906 miRNATAP -0.200612762607263 5.63146477400131e-06 NA NA NA hsa-miR-15b-5p INSR -1.25935038177398 1.83460220856901e-12 0.072568705841749 0.687422001875906 miRNATAP -0.175362598837309 0.000110773407928035 NA NA NA hsa-miR-16-5p INSR 0.749619098384047 4.11649450706988e-06 0.072568705841749 0.687422001875906 miRNATAP -0.254218737256182 4.56844501195278e-07 NA NA NA hsa-miR-181a-5p INSR -0.375429731222937 0.0562142867129802 0.072568705841749 0.687422001875906 mirMAP -0.117544426204587 0.00550204397365251 NA NA NA hsa-miR-181b-5p INSR 0.668793269169928 0.000239998092406404 0.072568705841749 0.687422001875906 mirMAP -0.173780381709745 0.000128395961704462 NA NA NA hsa-miR-186-5p INSR 0.852175445703945 6.88885738584309e-10 0.072568705841749 0.687422001875906 mirMAP -0.200951314334329 0.000747227365469451 NA NA NA hsa-miR-26b-5p INSR 0.72362441215247 4.7794659748036e-05 0.072568705841749 0.687422001875906 miRNAWalker2_validate -0.114701829602454 0.0138285373249273 21901137 IR in miR-26b overexpressed H1299 cells could not induce expression of ATF2; From these results we concluded that IR-induced up-regulation of ATF2 was coordinately enhanced by suppression of miR-26b in lung cancer cells which may enhance the effect of IR in the MAPK signaling pathway lung cancer hsa-miR-27a-3p INSR 0.433402568013802 0.00737164631768323 0.072568705841749 0.687422001875906 miRNATAP -0.108950522917326 0.0350660932466609 NA NA NA hsa-miR-30a-3p INSR -2.54042202792785 2.9111625410859e-18 0.072568705841749 0.687422001875906 mirMAP -0.104571944539812 0.000124653355600104 25582198 Role of microRNA 30a targeting insulin receptor substrate 2 in colorectal tumorigenesis; Moreover bioinformatic algorithms and luciferase reporter assays revealed that insulin receptor substrate 2 IRS2 is a direct target of miR-30a tumorigenesis colorectal cancer hsa-miR-30e-3p INSR -0.104420043859122 0.526240453209293 0.072568705841749 0.687422001875906 mirMAP -0.256243498262524 3.55354622595702e-07 NA NA NA hsa-miR-342-3p INSR -0.128691966564961 0.561034080130801 0.072568705841749 0.687422001875906 miRanda -0.189578932203005 3.55828930027543e-07 NA NA NA hsa-miR-361-5p INSR 0.21454431962475 0.0800957579368424 0.072568705841749 0.687422001875906 miRanda -0.224157815213429 0.0011296295717728 NA NA NA hsa-miR-374a-3p INSR 1.73882813668241 1.57901646296214e-13 0.072568705841749 0.687422001875906 mirMAP -0.140068896396232 4.07063958462341e-05 NA NA NA hsa-miR-424-5p INSR 1.26485330287919 6.1498991028257e-06 0.072568705841749 0.687422001875906 miRNATAP -0.145781011286284 5.38557964947113e-07 NA NA NA hsa-miR-590-3p INSR 0.83851360565783 0.00129224433453587 0.072568705841749 0.687422001875906 PITA;miRanda;mirMAP;miRNATAP -0.160616185203576 2.20508605665908e-05 NA NA NA hsa-miR-590-5p INSR 2.07441240363458 4.95240551694843e-14 0.072568705841749 0.687422001875906 mirMAP -0.141781156333303 9.05987480029783e-05 NA NA NA hsa-miR-194-5p IPCEF1 1.76979641760284 8.2064222072696e-05 0.312978895278994 0.353230938664371 mirMAP -0.159377402104554 2.6941098177859e-06 NA NA NA hsa-miR-194-5p ITGA9 1.76979641760284 8.2064222072696e-05 -1.26835931374769 0.00010826182322474 miRNAWalker2_validate;miRTarBase -0.158507076858585 1.85475935959352e-06 NA NA NA hsa-miR-940 JMJD7-PLA2G4B 0.011138136211269 0.974925352379525 -0.400430522628583 0.0339399904766164 miRNATAP -0.117383627060937 1.87570641851953e-05 NA NA NA hsa-miR-15a-5p KDR 1.62575353599172 1.55312121019827e-19 -1.29217133319599 5.17137540720335e-06 miRNATAP -0.277469551547698 8.30946725476635e-05 NA NA NA hsa-miR-16-5p KDR 0.749619098384047 4.11649450706988e-06 -1.29217133319599 5.17137540720335e-06 miRTarBase;miRNATAP -0.302391399126077 0.000178613946334273 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2 colorectal cancer hsa-miR-19b-1-5p KDR 1.71217036351784 3.28561659177495e-12 -1.29217133319599 5.17137540720335e-06 miRNAWalker2_validate -0.215943064538471 0.000357453344573502 NA NA NA hsa-miR-200c-3p KDR 0.380533388300368 0.0842181838538353 -1.29217133319599 5.17137540720335e-06 miRNATAP -0.266060212567765 8.13005514869735e-06 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-429 KDR 2.3794516574089 1.72813419703734e-13 -1.29217133319599 5.17137540720335e-06 PITA;miRanda;miRNATAP -0.111419145999383 0.00975571919411248 NA NA NA hsa-miR-590-3p KDR 0.83851360565783 0.00129224433453587 -1.29217133319599 5.17137540720335e-06 miRanda -0.242141052927696 5.91937848623311e-05 NA NA NA hsa-miR-590-5p KDR 2.07441240363458 4.95240551694843e-14 -1.29217133319599 5.17137540720335e-06 miRanda -0.245958719964099 1.91688320565153e-05 NA NA NA hsa-miR-194-5p KHDRBS2 1.76979641760284 8.2064222072696e-05 -3.2607116553015 7.89458794908715e-11 MirTarget -0.213085917448296 3.88218918038194e-05 NA NA NA hsa-miR-128-3p KIT 1.03509868349735 2.11606310588315e-10 -0.670683951943938 0.13028904543406 MirTarget -0.298481828365466 0.016189496715226 NA NA NA hsa-miR-142-5p KIT 1.29672439149353 4.0768822158894e-06 -0.670683951943938 0.13028904543406 PITA;miRNATAP -0.267920547512676 0.000579634804390746 NA NA NA hsa-miR-146b-5p KIT 1.0922867893808 5.63754607494775e-06 -0.670683951943938 0.13028904543406 miRNAWalker2_validate -0.403199974103019 1.39869069166224e-06 NA NA NA hsa-miR-193a-3p KIT 0.549173467360291 0.0319030569365466 -0.670683951943938 0.13028904543406 MirTarget;PITA;miRanda;miRNATAP -0.59184224535654 2.97374812152241e-12 NA NA NA hsa-miR-205-5p KIT 1.45372157280932 0.0361802982284339 -0.670683951943938 0.13028904543406 miRNATAP -0.112713698569041 0.000113293586471105 NA NA NA hsa-miR-221-3p KIT -0.0986794612964683 0.654454148658401 -0.670683951943938 0.13028904543406 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.885086313819054 1.85865395223136e-23 NA NA NA hsa-miR-222-3p KIT 0.0327210697409583 0.881937768109611 -0.670683951943938 0.13028904543406 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.889501207966653 1.1576183436693e-23 NA NA NA hsa-miR-34a-5p KIT 1.40588612517769 8.60097477768592e-12 -0.670683951943938 0.13028904543406 MirTarget -0.262099438612708 0.00709787631839905 NA NA NA hsa-miR-34c-5p KIT -1.00125440032112 0.0724432896090357 -0.670683951943938 0.13028904543406 MirTarget;miRanda -0.139621200199509 0.000276467908620036 NA NA NA hsa-miR-421 KIT 0.170525317701774 0.535277026680289 -0.670683951943938 0.13028904543406 miRanda -0.184058286887234 0.0230053569882627 NA NA NA hsa-miR-450b-5p KIT 1.69248953402469 1.96052058003353e-07 -0.670683951943938 0.13028904543406 MirTarget -0.290374682881939 2.52526370242336e-05 NA NA NA hsa-miR-590-3p KIT 0.83851360565783 0.00129224433453587 -0.670683951943938 0.13028904543406 miRanda;mirMAP -0.221636175469814 0.0182889119624238 NA NA NA hsa-miR-671-5p KIT 2.24156654191798 2.10433241567652e-14 -0.670683951943938 0.13028904543406 MirTarget -0.173173164825773 0.03270080387572 NA NA NA hsa-miR-185-5p KITLG 1.14291034858482 2.95777119743491e-13 -0.407275826421595 0.0946876733686214 miRNAWalker2_validate -0.225593244321958 0.00134638214857205 NA NA NA hsa-miR-186-5p KITLG 0.852175445703945 6.88885738584309e-10 -0.407275826421595 0.0946876733686214 mirMAP -0.285225701747334 0.00040690121762201 NA NA NA hsa-miR-19a-3p KITLG 2.11776595911517 7.07663078397156e-10 -0.407275826421595 0.0946876733686214 mirMAP -0.179513041617669 2.34814882455816e-06 NA NA NA hsa-miR-19b-3p KITLG 2.10868505662119 5.40846613768389e-17 -0.407275826421595 0.0946876733686214 mirMAP -0.166422952440393 0.000239418829583062 NA NA NA hsa-miR-22-5p KITLG 1.71436244278242 9.85038001236064e-15 -0.407275826421595 0.0946876733686214 MirTarget -0.268500442622934 3.5911841394099e-08 NA NA NA hsa-miR-222-3p KITLG 0.0327210697409583 0.881937768109611 -0.407275826421595 0.0946876733686214 miRNAWalker2_validate -0.167620175262976 0.00103681141128354 NA NA NA hsa-miR-23a-3p KITLG 0.111958289789488 0.393086414480463 -0.407275826421595 0.0946876733686214 mirMAP -0.178438096914284 0.0410345060747953 NA NA NA hsa-miR-26b-5p KITLG 0.72362441215247 4.7794659748036e-05 -0.407275826421595 0.0946876733686214 mirMAP -0.221906119294713 0.00041815365420821 NA NA NA hsa-miR-30c-5p KITLG -0.327319105755825 0.123595832152687 -0.407275826421595 0.0946876733686214 mirMAP -0.12063344053004 0.0230575011061627 NA NA NA hsa-miR-320b KITLG 0.226640952564488 0.378818692487242 -0.407275826421595 0.0946876733686214 MirTarget;PITA;miRanda -0.147496807582738 0.0007165511642918 NA NA NA hsa-miR-345-5p KITLG 1.48924745604581 1.54134850666509e-06 -0.407275826421595 0.0946876733686214 MirTarget -0.139326030301378 9.39386393271972e-05 NA NA NA hsa-miR-34a-5p KITLG 1.40588612517769 8.60097477768592e-12 -0.407275826421595 0.0946876733686214 MirTarget -0.113256152552181 0.0345153961310614 NA NA NA hsa-miR-374b-5p KITLG 0.474691035780475 0.0109217471394203 -0.407275826421595 0.0946876733686214 mirMAP -0.210152527144486 0.000962913430509178 NA NA NA hsa-miR-589-3p KITLG 1.34253876396688 1.84935927493927e-05 -0.407275826421595 0.0946876733686214 mirMAP -0.125477431701804 0.000602721030582728 NA NA NA hsa-miR-590-3p KITLG 0.83851360565783 0.00129224433453587 -0.407275826421595 0.0946876733686214 MirTarget;PITA;miRanda -0.197006393084599 0.000125114698530626 NA NA NA hsa-miR-7-1-3p KITLG 2.61364240402652 1.98959237815786e-32 -0.407275826421595 0.0946876733686214 mirMAP -0.210573081033874 2.39872381914342e-05 NA NA NA hsa-miR-9-5p KITLG 4.99250901331516 2.59132733422801e-19 -0.407275826421595 0.0946876733686214 MirTarget -0.107182895596496 1.97865014789599e-08 NA NA NA hsa-let-7a-3p KRAS 0.167285443861993 0.431834813181487 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.165605931792738 5.41329968030116e-05 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-let-7b-3p KRAS -1.81889978084306 6.9913416210266e-19 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.21045052897075 5.92266664846517e-09 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;26581910;22584434;26516699;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS;Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA;Interestingly the differential expression of miRNA in mice also corroborated with the miRNA expression in human PC cell lines and tissue samples; ectopic expression of Let-7b in CD18/HPAF and Capan1 cells resulted in the downregulation of KRAS and MSST1 expression;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;;;; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;pancreatic cancer;lung squamous cell cancer hsa-miR-1-3p KRAS -1.48412019995919 0.000242034342580425 0.538115716643554 0.00142410994615815 MirTarget -0.1135101654678 3.65182035802432e-08 NA NA NA hsa-miR-126-3p KRAS 0.397563736477277 0.115641762947829 0.538115716643554 0.00142410994615815 miRNAWalker2_validate;miRTarBase -0.140662247102959 4.48695871977096e-06 22845403 miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK pancreatic cancer hsa-miR-1271-5p KRAS -0.0172769786790662 0.951102370899887 0.538115716643554 0.00142410994615815 MirTarget -0.111352851066065 6.81606802337118e-05 NA NA NA hsa-miR-140-3p KRAS -1.11373309124537 8.35257079443689e-14 0.538115716643554 0.00142410994615815 MirTarget -0.379051955627805 3.51513569284386e-14 NA NA NA hsa-miR-155-5p KRAS 0.813513839059142 0.000608282725633232 0.538115716643554 0.00142410994615815 miRNAWalker2_validate;miRNATAP -0.136672576377435 2.71388112053399e-05 NA NA NA hsa-miR-16-1-3p KRAS 1.50034693398929 6.63958242991125e-10 0.538115716643554 0.00142410994615815 mirMAP -0.120692099076156 0.0020633534672843 NA NA NA hsa-miR-181a-5p KRAS -0.375429731222937 0.0562142867129802 0.538115716643554 0.00142410994615815 miRNAWalker2_validate -0.232892392323763 2.90389285591447e-09 24098024;27517749;26124189 The KRAS mutational status was determined by pyrosequencing and miR-181a expression was measured by quantitative RT-PCR in CRC tumour tissue and corresponding non-neoplastic colon tissue;Here we report that miR-181a directly binds to 3'-untranslated regions UTRs; downregulates KRAS NRAS and MAPK1; and decreases AML growth; The delivery of miR-181a mimics to target AML cells using transferrin-targeting lipopolyplex nanoparticles NP increased mature miR-181a; downregulated KRAS NRAS and MAPK1; and resulted in decreased phosphorylation of the downstream RAS effectors;MiR 181a 5p inhibits cell proliferation and migration by targeting Kras in non small cell lung cancer A549 cells; Luciferase activity assay results demonstrated that two binding sites of Kras could be directly targeted by miR-181a-5p; Furthermore Kras was down-regulated by miR-181a-5p at both transcriptional and translational levels; SiRNA-mediated Kras down-regulation could mimic the effects of miR-181a-5p mimic in A549 cells; Our findings suggest that miR-181a-5p plays a potential role in tumor suppression by partially targeting Kras and has the potential therapeutic application in NSCLC patients ;; colorectal cancer;acute myeloid leukemia;lung squamous cell cancer hsa-miR-181c-5p KRAS 0.529875814537156 0.0125885822998008 0.538115716643554 0.00142410994615815 miRNAWalker2_validate;miRTarBase -0.113481461651682 0.00199940913466899 NA NA NA hsa-miR-186-5p KRAS 0.852175445703945 6.88885738584309e-10 0.538115716643554 0.00142410994615815 mirMAP -0.173206213582145 0.0020136892983084 NA NA NA hsa-miR-193a-3p KRAS 0.549173467360291 0.0319030569365466 0.538115716643554 0.00142410994615815 MirTarget;miRanda;miRNATAP -0.114033878061734 0.000545245334645599 NA NA NA hsa-miR-193a-5p KRAS -1.15938257046946 2.61709321247277e-08 0.538115716643554 0.00142410994615815 miRNATAP -0.136206451672479 0.000220728848496 NA NA NA hsa-miR-195-3p KRAS -1.33068822339418 6.65427393047357e-09 0.538115716643554 0.00142410994615815 mirMAP -0.26052009331858 1.37547972270525e-15 NA NA NA hsa-miR-199a-5p KRAS 1.3057193856884 2.38429382751645e-08 0.538115716643554 0.00142410994615815 miRanda;miRNATAP -0.190569403157002 4.12804905993219e-09 NA NA NA hsa-miR-199b-5p KRAS 2.13822205171062 4.56262988762436e-15 0.538115716643554 0.00142410994615815 miRanda;miRNATAP -0.160083363830103 4.62674745647173e-09 27517624 The miR-199b prognostic impact was particularly evident in both younger and KRAS wild-type subgroups colorectal cancer hsa-miR-224-3p KRAS 0.921090817288022 0.010010047721564 0.538115716643554 0.00142410994615815 mirMAP -0.11580794239374 2.34601235413632e-07 25919696 MicroRNA 224 is associated with colorectal cancer progression and response to 5 fluorouracil based chemotherapy by KRAS dependent and independent mechanisms; MicroRNA-224 was differentially expressed in dysplastic colorectal disease and in isogeneic KRAS WT and mutant HCT116 cells; 5-FU chemosensitivity was significantly increased in miR-224 knockdown cells and in NIH3T3 cells expressing KRAS and BRAF mutant proteins progression;drug resistance colorectal cancer hsa-miR-27b-3p KRAS 0.236438984240408 0.12263510345883 0.538115716643554 0.00142410994615815 miRNATAP -0.140671332847896 0.00626162133896643 NA NA NA hsa-miR-30a-3p KRAS -2.54042202792785 2.9111625410859e-18 0.538115716643554 0.00142410994615815 MirTarget;miRNATAP -0.122460927678546 1.58218389307393e-06 NA NA NA hsa-miR-30a-5p KRAS -0.924084264430689 0.000762030454634728 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.160923145065632 7.88859261457886e-09 NA NA NA hsa-miR-30b-5p KRAS 0.358144314839612 0.138026229059594 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.147252408030935 4.51771159246383e-06 NA NA NA hsa-miR-30c-5p KRAS -0.327319105755825 0.123595832152687 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.303491851342304 1.38338910293015e-17 22701724 Deregulated miRNAs in hereditary breast cancer revealed a role for miR 30c in regulating KRAS oncogene; In particular we experimentally validated KRAS as a miR-30c target; Luciferase assays confirmed that miR-30c binds the 3'UTR of KRAS transcripts and expression of pre-miR-30c down-regulated KRAS mRNA and protein; In addition we provide evidence that KRAS is a target of miR-30c and that this miRNA suppresses breast cancer cell growth potentially through inhibition of KRAS signaling breast cancer hsa-miR-30d-3p KRAS 0.00396376345349925 0.986457040013182 0.538115716643554 0.00142410994615815 MirTarget;miRNATAP -0.12073831042602 0.00128170411687249 NA NA NA hsa-miR-30d-5p KRAS -0.920901858717441 3.50898334321668e-05 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.124035278299491 0.000357846902820112 NA NA NA hsa-miR-30e-3p KRAS -0.104420043859122 0.526240453209293 0.538115716643554 0.00142410994615815 MirTarget -0.254543853548427 7.09600327106139e-08 NA NA NA hsa-miR-30e-5p KRAS 1.60414100786743 3.78951090573667e-19 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.125942634043968 0.00267795482717309 NA NA NA hsa-miR-501-3p KRAS -0.0405952693028064 0.866802243505833 0.538115716643554 0.00142410994615815 MirTarget;PITA;TargetScan;miRNATAP -0.124338029852589 0.000111299015637681 NA NA NA hsa-miR-502-3p KRAS -0.262270070977708 0.161760375279961 0.538115716643554 0.00142410994615815 MirTarget;PITA;miRNATAP -0.116432061546502 0.00538025775498572 NA NA NA hsa-miR-532-5p KRAS 0.576620898517708 0.0023245812680956 0.538115716643554 0.00142410994615815 MirTarget;PITA;miRNATAP -0.123485597460216 0.00273306142385404 NA NA NA hsa-miR-221-5p KSR1 -2.2173523967387 1.8954728277084e-09 0.245452869731261 0.330389049022197 mirMAP -0.266357961072455 4.4447348012266e-18 NA NA NA hsa-miR-28-5p KSR1 1.19639196514745 4.59365801666536e-18 0.245452869731261 0.330389049022197 miRanda -0.186947920675278 0.0227944738526654 NA NA NA hsa-miR-30a-5p KSR1 -0.924084264430689 0.000762030454634728 0.245452869731261 0.330389049022197 MirTarget -0.105939342753492 0.0119230709968849 NA NA NA hsa-miR-330-3p KSR1 -0.716924999893351 0.000796236278616087 0.245452869731261 0.330389049022197 MirTarget -0.119215990839634 0.0281934775452099 NA NA NA hsa-miR-378c KSR1 -1.1528833105561 7.25986666044199e-07 0.245452869731261 0.330389049022197 miRNATAP -0.23420600418738 1.8620236757607e-06 NA NA NA hsa-miR-542-3p KSR1 1.62226640768239 2.6427102465476e-10 0.245452869731261 0.330389049022197 mirMAP -0.100514483657439 0.0236753953639052 NA NA NA hsa-let-7a-2-3p KSR2 1.34046246689099 0.000367955143268581 -0.188212407417219 0.632075355314908 mirMAP -0.209331514659329 1.04839006195187e-05 NA NA NA hsa-miR-126-5p KSR2 0.851637714492907 0.000391373420568359 -0.188212407417219 0.632075355314908 mirMAP -0.172055841253221 0.0221088190336049 NA NA NA hsa-miR-132-3p KSR2 0.0122601212105202 0.934032846062939 -0.188212407417219 0.632075355314908 mirMAP;miRNATAP -0.269748621001861 0.0296342446917496 NA NA NA hsa-miR-140-5p KSR2 0.669142684153918 0.000335928403032308 -0.188212407417219 0.632075355314908 mirMAP -0.38455720103973 0.00010592903622257 NA NA NA hsa-miR-142-5p KSR2 1.29672439149353 4.0768822158894e-06 -0.188212407417219 0.632075355314908 mirMAP -0.263941331411598 0.000126480215465079 NA NA NA hsa-miR-144-3p KSR2 -2.1603497940894 3.64553026877274e-07 -0.188212407417219 0.632075355314908 mirMAP -0.141515622076757 0.00141923149647242 NA NA NA hsa-miR-155-5p KSR2 0.813513839059142 0.000608282725633232 -0.188212407417219 0.632075355314908 mirMAP -0.257888805585757 0.000676846810003011 NA NA NA hsa-miR-185-5p KSR2 1.14291034858482 2.95777119743491e-13 -0.188212407417219 0.632075355314908 mirMAP -0.329354785326232 0.00372100316152906 NA NA NA hsa-miR-193b-5p KSR2 0.179695858885499 0.55521472494233 -0.188212407417219 0.632075355314908 mirMAP -0.175064272027447 0.00325379991708538 NA NA NA hsa-miR-212-3p KSR2 0.404496907089793 0.103551762277891 -0.188212407417219 0.632075355314908 mirMAP;miRNATAP -0.176518999850571 0.0156084498874907 NA NA NA hsa-miR-22-5p KSR2 1.71436244278242 9.85038001236064e-15 -0.188212407417219 0.632075355314908 mirMAP -0.269994267334974 0.00066601785428077 NA NA NA hsa-miR-223-3p KSR2 -0.51475567451355 0.0609181549839239 -0.188212407417219 0.632075355314908 mirMAP -0.174558590378232 0.00807937076357313 NA NA NA hsa-miR-23a-3p KSR2 0.111958289789488 0.393086414480463 -0.188212407417219 0.632075355314908 mirMAP -0.489641716785418 0.000477081667291786 NA NA NA hsa-miR-29a-5p KSR2 1.89519956688438 1.03453349363915e-11 -0.188212407417219 0.632075355314908 mirMAP -0.184705763198763 0.0151654393620345 NA NA NA hsa-miR-3614-5p KSR2 -1.19394699210224 2.53933783780868e-05 -0.188212407417219 0.632075355314908 mirMAP -0.244695184792833 0.000108536384678818 NA NA NA hsa-miR-378a-5p KSR2 -1.22647878854015 9.72314015412955e-08 -0.188212407417219 0.632075355314908 mirMAP -0.253410401706526 0.00110195215607072 NA NA NA hsa-miR-452-3p KSR2 0.477736876273128 0.22218404598603 -0.188212407417219 0.632075355314908 mirMAP -0.116795656596576 0.0301332783316862 NA NA NA hsa-miR-486-5p KSR2 -4.38592782786845 2.75864166493846e-29 -0.188212407417219 0.632075355314908 mirMAP -0.115462778976759 0.00780574565646162 NA NA NA hsa-miR-550a-3p KSR2 0.0186193291188046 0.949896722138275 -0.188212407417219 0.632075355314908 mirMAP -0.144155489860012 0.0226586391633376 NA NA NA hsa-miR-590-3p KSR2 0.83851360565783 0.00129224433453587 -0.188212407417219 0.632075355314908 mirMAP -0.318950326366805 0.00011661616473952 NA NA NA hsa-miR-590-5p KSR2 2.07441240363458 4.95240551694843e-14 -0.188212407417219 0.632075355314908 mirMAP -0.248616718279827 0.00171818307030168 NA NA NA hsa-miR-629-3p KSR2 1.31892116211001 0.000114487182853678 -0.188212407417219 0.632075355314908 mirMAP -0.135371186767253 0.0177838983558259 NA NA NA hsa-miR-194-5p MAP1B 1.76979641760284 8.2064222072696e-05 0.0316547433168237 0.923894756885102 MirTarget -0.148561032229876 8.69094409178794e-06 NA NA NA hsa-miR-194-5p MAP2 1.76979641760284 8.2064222072696e-05 -1.20387553493088 0.000895067915840975 MirTarget;miRNATAP -0.129266287276654 0.000460273664807576 NA NA NA hsa-miR-30c-5p MAP2K1 -0.327319105755825 0.123595832152687 -0.126507255559492 0.255813608366235 miRNAWalker2_validate -0.148243346155614 3.94199903529302e-10 NA NA NA hsa-miR-497-5p MAP2K1 -0.0546347378264729 0.786205564901684 -0.126507255559492 0.255813608366235 miRNAWalker2_validate -0.146950542279665 4.9483059880063e-09 NA NA NA hsa-miR-130a-3p MAPK1 0.881660100597014 0.000158893668519248 -0.313704159534906 0.0065740365500908 mirMAP -0.101872197195 5.97373126035408e-06 NA NA NA hsa-miR-140-5p MAPK1 0.669142684153918 0.000335928403032308 -0.313704159534906 0.0065740365500908 miRanda -0.105360739553965 0.000299450445528468 NA NA NA hsa-miR-148a-3p MAPK1 2.30885799126944 1.95226081368985e-21 -0.313704159534906 0.0065740365500908 mirMAP -0.102558880400122 7.51166113357563e-07 NA NA NA hsa-miR-24-1-5p MAPK1 0.856025727237819 0.000107354490323658 -0.313704159534906 0.0065740365500908 mirMAP -0.114103342147363 5.37066958548902e-06 NA NA NA hsa-miR-29a-5p MAPK1 1.89519956688438 1.03453349363915e-11 -0.313704159534906 0.0065740365500908 mirMAP -0.100646824836984 5.49015969248301e-06 NA NA NA hsa-miR-29b-3p MAPK1 3.10527711861309 3.01242507282711e-32 -0.313704159534906 0.0065740365500908 mirMAP -0.122356815748067 3.56933939779318e-11 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-342-3p MAPK1 -0.128691966564961 0.561034080130801 -0.313704159534906 0.0065740365500908 miRanda;mirMAP -0.137175460423021 7.76879946497687e-09 NA NA NA hsa-miR-34a-5p MAPK1 1.40588612517769 8.60097477768592e-12 -0.313704159534906 0.0065740365500908 mirMAP -0.105828142272272 2.59913448288353e-05 NA NA NA hsa-miR-454-3p MAPK1 1.49453641052169 4.46235742871434e-09 -0.313704159534906 0.0065740365500908 mirMAP -0.104171229052281 2.01455003951624e-05 NA NA NA hsa-miR-130b-3p MAPK10 1.83046548750752 5.04753914574694e-13 -1.84555409354538 2.44653235090281e-07 miRNATAP -0.537034366335229 2.86966630336949e-16 NA NA NA hsa-miR-193a-3p MAPK10 0.549173467360291 0.0319030569365466 -1.84555409354538 2.44653235090281e-07 miRanda;miRNATAP -0.208049144667707 0.0032825904748623 NA NA NA hsa-miR-19a-3p MAPK10 2.11776595911517 7.07663078397156e-10 -1.84555409354538 2.44653235090281e-07 miRNATAP -0.265750080258195 2.59683060133796e-06 NA NA NA hsa-miR-19b-3p MAPK10 2.10868505662119 5.40846613768389e-17 -1.84555409354538 2.44653235090281e-07 miRNATAP -0.189921398261328 0.00493497607488942 NA NA NA hsa-miR-29b-3p MAPK10 3.10527711861309 3.01242507282711e-32 -1.84555409354538 2.44653235090281e-07 miRNATAP -0.171823093280894 0.0036980764764073 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-301a-3p MAPK10 2.70198002906399 1.56420889710984e-14 -1.84555409354538 2.44653235090281e-07 miRNATAP -0.174017260988062 0.00229185658757323 NA NA NA hsa-miR-450b-5p MAPK10 1.69248953402469 1.96052058003353e-07 -1.84555409354538 2.44653235090281e-07 mirMAP -0.186795960249825 0.000949224747958845 NA NA NA hsa-miR-582-5p MAPK10 1.08286181406653 0.00149040450161757 -1.84555409354538 2.44653235090281e-07 PITA -0.23826284159421 1.53674093759886e-06 NA NA NA hsa-miR-590-3p MAPK10 0.83851360565783 0.00129224433453587 -1.84555409354538 2.44653235090281e-07 miRanda;mirMAP -0.487483452887983 9.33422066806689e-11 NA NA NA hsa-miR-590-5p MAPK10 2.07441240363458 4.95240551694843e-14 -1.84555409354538 2.44653235090281e-07 PITA;miRanda;miRNATAP -0.563200566282606 2.40959066969729e-15 NA NA NA hsa-miR-940 MAPK10 0.011138136211269 0.974925352379525 -1.84555409354538 2.44653235090281e-07 PITA;miRNATAP -0.159477320006351 0.00256734578442865 NA NA NA hsa-let-7a-3p MAPK8 0.167285443861993 0.431834813181487 0.0632162214250305 0.668341664440464 mirMAP -0.157930246462243 9.14454944313728e-06 NA NA NA hsa-miR-125a-5p MAPK8 -1.04824536696301 3.97386082850476e-07 0.0632162214250305 0.668341664440464 miRNAWalker2_validate -0.15184015518388 2.49402331215943e-06 NA NA NA hsa-miR-140-3p MAPK8 -1.11373309124537 8.35257079443689e-14 0.0632162214250305 0.668341664440464 miRNAWalker2_validate -0.229670226577472 2.02179196215716e-07 NA NA NA hsa-miR-195-3p MAPK8 -1.33068822339418 6.65427393047357e-09 0.0632162214250305 0.668341664440464 mirMAP -0.164652345751543 1.11399258189077e-08 NA NA NA hsa-miR-214-3p MAPK8 -1.1136198715556 3.52054933799089e-05 0.0632162214250305 0.668341664440464 miRNAWalker2_validate -0.129072885991343 1.85416115952081e-07 19859982 HeLa cells that stably overexpress miR-214 downregulate the expression of MEK3 and JNK1 at both mRNA and protein levels; Further investigation revealed that miR-214 regulates the expression of MEK3 and JNK1 by targeting the 3'UTRs of these genes; Collectively these results suggest that miR-214 negatively regulates HeLa cell proliferation by targeting the noncoding regions of MEK3 and JNK1 mRNAs cervical and endocervical cancer hsa-miR-22-5p MAPK8 1.71436244278242 9.85038001236064e-15 0.0632162214250305 0.668341664440464 mirMAP -0.167203909807138 1.25459746890825e-08 NA NA NA hsa-miR-29a-5p MAPK8 1.89519956688438 1.03453349363915e-11 0.0632162214250305 0.668341664440464 mirMAP -0.109660256227403 0.000108946728883364 NA NA NA hsa-miR-30a-5p MAPK8 -0.924084264430689 0.000762030454634728 0.0632162214250305 0.668341664440464 mirMAP -0.132224175920583 5.22028416854406e-08 NA NA NA hsa-miR-30b-5p MAPK8 0.358144314839612 0.138026229059594 0.0632162214250305 0.668341664440464 mirMAP -0.189225193682518 6.26006883961534e-12 NA NA NA hsa-miR-30c-5p MAPK8 -0.327319105755825 0.123595832152687 0.0632162214250305 0.668341664440464 mirMAP -0.293359915087209 9.16213981476922e-22 NA NA NA hsa-miR-30e-5p MAPK8 1.60414100786743 3.78951090573667e-19 0.0632162214250305 0.668341664440464 mirMAP -0.114539805431751 0.00167549358780215 NA NA NA hsa-miR-590-5p MAPK9 2.07441240363458 4.95240551694843e-14 -0.0267974823319514 0.832365388512273 miRanda -0.113762314687669 6.92148479015732e-06 NA NA NA hsa-miR-93-5p MAPK9 1.50844106515467 1.83836866996875e-12 -0.0267974823319514 0.832365388512273 miRNAWalker2_validate;miRNATAP -0.122466377512421 3.34521997692581e-06 NA NA NA hsa-miR-450a-5p MDM2 1.94284269183615 1.52883075909271e-07 -0.018010582169941 0.916081437185101 mirMAP -0.108762560851161 1.20807844291087e-05 NA NA NA hsa-miR-194-5p MEF2C 1.76979641760284 8.2064222072696e-05 -0.861737319401213 4.52234474023972e-05 miRNATAP -0.125520456446742 3.77755083399058e-09 NA NA NA hsa-miR-450a-5p MEIS2 1.94284269183615 1.52883075909271e-07 -1.00229516914565 2.42581085064298e-06 miRNATAP -0.10772036115909 0.000610043455149123 NA NA NA hsa-miR-130a-3p MET 0.881660100597014 0.000158893668519248 0.183477493526328 0.659377403748523 miRNAWalker2_validate -0.20355111252315 0.012864079532928 NA NA NA hsa-miR-30d-3p MET 0.00396376345349925 0.986457040013182 0.183477493526328 0.659377403748523 mirMAP -0.370227369375165 5.63086912296213e-05 NA NA NA hsa-miR-324-5p MET 1.06955541886548 5.39722006604758e-05 0.183477493526328 0.659377403748523 miRanda -0.352488833333601 7.48796940482076e-07 NA NA NA hsa-miR-421 MET 0.170525317701774 0.535277026680289 0.183477493526328 0.659377403748523 miRanda -0.192442489138971 0.0112160582800174 NA NA NA hsa-miR-532-3p MET -0.677758187385834 0.0147557885796065 0.183477493526328 0.659377403748523 PITA -0.143287600688713 0.0377424140639414 NA NA NA hsa-miR-664a-3p MET 0.443077463053857 0.0214248925850984 0.183477493526328 0.659377403748523 mirMAP -0.324625189996636 0.00113329920907825 NA NA NA hsa-miR-450a-5p MGAT5 1.94284269183615 1.52883075909271e-07 -0.247727111180191 0.353990823426736 mirMAP -0.227274506451063 3.96173596374772e-09 NA NA NA hsa-miR-194-5p MPZL2 1.76979641760284 8.2064222072696e-05 0.0942740857372852 0.724548612568742 MirTarget -0.105154932399228 0.000100046371301186 NA NA NA hsa-miR-135b-5p MRAS 3.25019233805845 1.95560099639034e-15 -1.26981042312752 2.25317279900632e-13 miRNATAP -0.126854161321085 8.1015479639163e-10 NA NA NA hsa-miR-182-5p MRAS 3.21839823004635 5.13049145201115e-39 -1.26981042312752 2.25317279900632e-13 miRNATAP -0.217367608565938 2.91641159096101e-13 NA NA NA hsa-miR-29b-3p MRAS 3.10527711861309 3.01242507282711e-32 -1.26981042312752 2.25317279900632e-13 mirMAP -0.107073014365824 0.000217065105807304 NA NA NA hsa-miR-324-5p MRAS 1.06955541886548 5.39722006604758e-05 -1.26981042312752 2.25317279900632e-13 miRanda -0.119444531077426 9.39636460614906e-05 NA NA NA hsa-miR-335-3p MRAS 1.51116383169018 6.88553098788624e-13 -1.26981042312752 2.25317279900632e-13 mirMAP -0.22409253609703 2.25863619602441e-09 NA NA NA hsa-miR-429 MRAS 2.3794516574089 1.72813419703734e-13 -1.26981042312752 2.25317279900632e-13 miRanda;miRNATAP -0.18614468940234 1.07502040516879e-12 NA NA NA hsa-miR-582-5p MRAS 1.08286181406653 0.00149040450161757 -1.26981042312752 2.25317279900632e-13 mirMAP -0.10905516124636 7.5406825441415e-06 NA NA NA hsa-miR-7-1-3p MRAS 2.61364240402652 1.98959237815786e-32 -1.26981042312752 2.25317279900632e-13 mirMAP -0.151233200906711 3.1959019331961e-05 NA NA NA hsa-miR-96-5p MRAS 3.0381097138467 4.40362891630201e-24 -1.26981042312752 2.25317279900632e-13 TargetScan;miRNATAP -0.176216903551529 2.20276024331134e-09 NA NA NA hsa-miR-194-5p MYO5A 1.76979641760284 8.2064222072696e-05 -0.523684821141466 0.00324176401244809 mirMAP -0.109198253837592 8.91319144717046e-10 NA NA NA hsa-miR-101-5p NF1 -0.0265235292039296 0.917878791358577 0.337750472021996 0.0168165069319537 MirTarget -0.14893967812297 1.96946584883157e-06 NA NA NA hsa-miR-195-5p NF1 -1.01577502605386 4.80814718341729e-05 0.337750472021996 0.0168165069319537 MirTarget -0.112894686236858 3.19944876113706e-05 NA NA NA hsa-miR-30c-5p NF1 -0.327319105755825 0.123595832152687 0.337750472021996 0.0168165069319537 MirTarget;mirMAP;miRNATAP -0.146273545917688 1.57100996298072e-06 NA NA NA hsa-miR-497-5p NF1 -0.0546347378264729 0.786205564901684 0.337750472021996 0.0168165069319537 MirTarget -0.113921993428693 0.000437659700777723 NA NA NA hsa-miR-590-3p NF1 0.83851360565783 0.00129224433453587 0.337750472021996 0.0168165069319537 MirTarget;PITA;miRanda;miRNATAP -0.106794316707531 0.000336101204223692 NA NA NA hsa-miR-450a-5p NFIX 1.94284269183615 1.52883075909271e-07 -1.87028417203866 4.16553494303762e-12 mirMAP -0.161897985044931 6.05375101577056e-05 NA NA NA hsa-miR-671-5p NFKB1 2.24156654191798 2.10433241567652e-14 -0.340270335589995 0.00609383891055805 MirTarget -0.104865468815509 3.02257267140541e-06 NA NA NA hsa-let-7b-5p NGF -1.62016148171663 1.56547487335694e-15 0.201813000750518 0.680403675107959 MirTarget -0.242858337482323 0.0246273998823271 NA NA NA hsa-miR-320a NGF -0.961144925954715 1.62478794429204e-08 0.201813000750518 0.680403675107959 miRanda -0.306575920656902 0.0199126531419783 NA NA NA hsa-miR-320b NGF 0.226640952564488 0.378818692487242 0.201813000750518 0.680403675107959 miRanda -0.175428791274416 0.0460777091944554 NA NA NA hsa-miR-148b-5p NGFR 1.39335695292409 2.13220380550073e-07 -0.756525762864907 0.0346308387633173 mirMAP -0.284790939209307 8.93729900479724e-05 NA NA NA hsa-miR-15b-3p NGFR 0.804736041893915 0.000400279611457186 -0.756525762864907 0.0346308387633173 mirMAP -0.247701108356659 0.00117487688828093 NA NA NA hsa-miR-185-3p NGFR -0.377490365509078 0.093653288903368 -0.756525762864907 0.0346308387633173 miRNATAP -0.159274452163468 0.0306425797922537 NA NA NA hsa-miR-2355-5p NGFR 1.86174980095465 3.47492783095613e-13 -0.756525762864907 0.0346308387633173 mirMAP -0.186100473533598 0.00644610713690332 NA NA NA hsa-miR-34a-5p NGFR 1.40588612517769 8.60097477768592e-12 -0.756525762864907 0.0346308387633173 mirMAP -0.189024340126912 0.0164268051765884 NA NA NA hsa-miR-145-5p NRAS -1.34926078156437 2.63526538800669e-07 0.110922789912811 0.412920190999736 miRNAWalker2_validate;MirTarget;miRNATAP -0.142760374746012 6.05977027346954e-10 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-148a-3p NRAS 2.30885799126944 1.95226081368985e-21 0.110922789912811 0.412920190999736 MirTarget -0.109343012733505 6.98144190286614e-06 NA NA NA hsa-miR-195-3p NRAS -1.33068822339418 6.65427393047357e-09 0.110922789912811 0.412920190999736 mirMAP -0.160994991063139 1.05944502094987e-09 NA NA NA hsa-miR-22-3p NRAS 1.42501909916631 1.72295005910055e-25 0.110922789912811 0.412920190999736 MirTarget;miRNATAP -0.128848632159027 0.00314401368706814 NA NA NA hsa-miR-26b-5p NRAS 0.72362441215247 4.7794659748036e-05 0.110922789912811 0.412920190999736 mirMAP;miRNATAP -0.130094780209659 0.000185700963505737 NA NA NA hsa-miR-27b-3p NRAS 0.236438984240408 0.12263510345883 0.110922789912811 0.412920190999736 miRNATAP -0.154582178613336 0.000157756473886806 NA NA NA hsa-miR-29a-3p NRAS 0.101650412194573 0.573201097011668 0.110922789912811 0.412920190999736 miRNATAP -0.156058827596967 6.08074898827527e-06 NA NA NA hsa-miR-29b-3p NRAS 3.10527711861309 3.01242507282711e-32 0.110922789912811 0.412920190999736 miRNATAP -0.130094390329954 2.14950403130123e-09 NA NA NA hsa-miR-29c-3p NRAS 1.32354490728858 1.84279305179762e-07 0.110922789912811 0.412920190999736 miRNATAP -0.132620598651339 2.93062944029642e-08 NA NA NA hsa-miR-320a NRAS -0.961144925954715 1.62478794429204e-08 0.110922789912811 0.412920190999736 mirMAP -0.138653847620251 0.000123789780187142 NA NA NA hsa-miR-502-3p NRAS -0.262270070977708 0.161760375279961 0.110922789912811 0.412920190999736 MirTarget -0.116067692488029 0.000491333225482351 NA NA NA hsa-miR-664a-3p NRAS 0.443077463053857 0.0214248925850984 0.110922789912811 0.412920190999736 MirTarget -0.339669060778621 8.1321923374988e-29 NA NA NA hsa-miR-194-5p NRP1 1.76979641760284 8.2064222072696e-05 -0.40252187730616 0.0377253868964042 miRNATAP -0.123624662567489 1.6118266673356e-10 NA NA NA hsa-miR-142-3p NTF3 3.98476449801341 1.56256182021111e-35 -1.21316884460928 0.000957794321386974 miRanda -0.132391088121297 0.00694622430224727 NA NA NA hsa-miR-200c-3p NTF3 0.380533388300368 0.0842181838538353 -1.21316884460928 0.000957794321386974 miRNAWalker2_validate;miRNATAP -0.208337360877354 0.00711208431360534 NA NA NA hsa-miR-21-5p NTF3 4.38165933891779 1.52536633902505e-92 -1.21316884460928 0.000957794321386974 miRTarBase;miRNATAP -0.277170192916863 1.64786275260932e-05 NA NA NA hsa-miR-222-3p NTF3 0.0327210697409583 0.881937768109611 -1.21316884460928 0.000957794321386974 miRNATAP -0.158531923952743 0.0412536546573784 NA NA NA hsa-miR-590-3p NTF3 0.83851360565783 0.00129224433453587 -1.21316884460928 0.000957794321386974 miRanda -0.251401735860011 0.00126362075034438 NA NA NA hsa-miR-590-5p NTF3 2.07441240363458 4.95240551694843e-14 -1.21316884460928 0.000957794321386974 PITA;miRanda;miRNATAP -0.192281133054364 0.0100039494488388 NA NA NA hsa-miR-185-3p NTRK1 -0.377490365509078 0.093653288903368 -1.20191019732804 0.000181518709629851 MirTarget -0.220344116634979 0.000867618792014595 NA NA NA hsa-miR-107 NTRK2 0.658676029898313 5.11480446318819e-07 -2.56364615593132 1.62911334525602e-08 PITA;miRanda -0.33602431707244 0.0393031250958749 NA NA NA hsa-miR-130b-3p NTRK2 1.83046548750752 5.04753914574694e-13 -2.56364615593132 1.62911334525602e-08 mirMAP -0.588115812319922 3.25886271258664e-12 NA NA NA hsa-miR-130b-5p NTRK2 1.53645187062942 1.10498816261505e-08 -2.56364615593132 1.62911334525602e-08 mirMAP -0.447056548884639 5.74660614017045e-09 NA NA NA hsa-miR-142-3p NTRK2 3.98476449801341 1.56256182021111e-35 -2.56364615593132 1.62911334525602e-08 miRanda -0.127407826107105 0.0379666830473019 NA NA NA hsa-miR-151a-5p NTRK2 1.23124135275661 2.93488020257558e-12 -2.56364615593132 1.62911334525602e-08 miRNATAP -0.404254240257679 0.000623285412545112 NA NA NA hsa-miR-15b-3p NTRK2 0.804736041893915 0.000400279611457186 -2.56364615593132 1.62911334525602e-08 mirMAP -0.277740657056852 0.00473888405637355 NA NA NA hsa-miR-17-3p NTRK2 1.36706429551147 4.60388403547821e-13 -2.56364615593132 1.62911334525602e-08 miRNATAP -0.462037732826128 2.48808237203963e-05 NA NA NA hsa-miR-181b-5p NTRK2 0.668793269169928 0.000239998092406404 -2.56364615593132 1.62911334525602e-08 mirMAP -0.285511737795578 0.0145904928278863 NA NA NA hsa-miR-182-5p NTRK2 3.21839823004635 5.13049145201115e-39 -2.56364615593132 1.62911334525602e-08 mirMAP -0.395114751858306 4.77623924189024e-07 NA NA NA hsa-miR-186-5p NTRK2 0.852175445703945 6.88885738584309e-10 -2.56364615593132 1.62911334525602e-08 mirMAP -0.340737644051519 0.0262837563601867 NA NA NA hsa-miR-20a-3p NTRK2 2.51803599558247 4.92479325298629e-13 -2.56364615593132 1.62911334525602e-08 mirMAP -0.364998835563012 1.65748631141832e-06 NA NA NA hsa-miR-21-5p NTRK2 4.38165933891779 1.52536633902505e-92 -2.56364615593132 1.62911334525602e-08 mirMAP -0.470648222362519 3.55420725351027e-09 NA NA NA hsa-miR-29a-5p NTRK2 1.89519956688438 1.03453349363915e-11 -2.56364615593132 1.62911334525602e-08 mirMAP -0.345867869966745 9.99636115678843e-05 NA NA NA hsa-miR-301a-3p NTRK2 2.70198002906399 1.56420889710984e-14 -2.56364615593132 1.62911334525602e-08 mirMAP -0.357966104712284 6.80841814025626e-07 NA NA NA hsa-miR-32-5p NTRK2 0.876853679269853 6.04859399018691e-05 -2.56364615593132 1.62911334525602e-08 mirMAP -0.236027895933631 0.0250009941441399 NA NA NA hsa-miR-320b NTRK2 0.226640952564488 0.378818692487242 -2.56364615593132 1.62911334525602e-08 mirMAP -0.286044846597318 0.000526912439992569 NA NA NA hsa-miR-335-3p NTRK2 1.51116383169018 6.88553098788624e-13 -2.56364615593132 1.62911334525602e-08 mirMAP -0.559361058530472 9.51509422827442e-09 NA NA NA hsa-miR-33a-5p NTRK2 2.80127809675219 5.09053890529424e-12 -2.56364615593132 1.62911334525602e-08 mirMAP -0.162539762754735 0.0103411022015968 NA NA NA hsa-miR-421 NTRK2 0.170525317701774 0.535277026680289 -2.56364615593132 1.62911334525602e-08 mirMAP -0.304690560726909 0.0002799728683427 NA NA NA hsa-miR-454-3p NTRK2 1.49453641052169 4.46235742871434e-09 -2.56364615593132 1.62911334525602e-08 mirMAP -0.333749932009109 0.000672846540177429 NA NA NA hsa-miR-576-5p NTRK2 1.02693643167056 1.14846964470173e-06 -2.56364615593132 1.62911334525602e-08 PITA;mirMAP -0.37738321255992 0.000150408264625595 NA NA NA hsa-miR-590-3p NTRK2 0.83851360565783 0.00129224433453587 -2.56364615593132 1.62911334525602e-08 PITA;miRanda;mirMAP -0.392514341110474 5.33682930755441e-05 NA NA NA hsa-miR-590-5p NTRK2 2.07441240363458 4.95240551694843e-14 -2.56364615593132 1.62911334525602e-08 miRanda;mirMAP -0.40715451036762 1.11592186360866e-05 NA NA NA hsa-miR-30c-2-3p PAK1 -3.10905250533941 6.84550165664783e-27 1.08615212555614 2.32491055448077e-14 MirTarget -0.154051600518757 6.58939241738245e-13 NA NA NA hsa-miR-342-3p PAK1 -0.128691966564961 0.561034080130801 1.08615212555614 2.32491055448077e-14 miRanda -0.11605740701123 0.000138325198264815 NA NA NA hsa-miR-186-5p PAK2 0.852175445703945 6.88885738584309e-10 -0.164896023734459 0.153652182388238 MirTarget -0.153349441471628 5.49359290719855e-05 NA NA NA hsa-miR-23b-3p PAK2 -0.070273068040148 0.620585267977425 -0.164896023734459 0.153652182388238 MirTarget -0.100289131217277 0.00816893039950937 NA NA NA hsa-miR-26b-5p PAK2 0.72362441215247 4.7794659748036e-05 -0.164896023734459 0.153652182388238 MirTarget;mirMAP;miRNATAP -0.173530495671578 3.35032912896637e-09 NA NA NA hsa-miR-29a-5p PAK2 1.89519956688438 1.03453349363915e-11 -0.164896023734459 0.153652182388238 mirMAP -0.119436627795289 5.70800029435606e-08 NA NA NA hsa-miR-455-5p PAK2 1.36946341828134 5.05118627562807e-08 -0.164896023734459 0.153652182388238 miRanda -0.109807631196541 4.38250829825112e-06 NA NA NA hsa-miR-146b-3p PAK3 -0.808296168180355 0.000870284326590347 -0.158206463549222 0.788653403324686 MirTarget;miRNATAP -0.396693458517324 0.000366007972561846 NA NA NA hsa-miR-146b-5p PAK3 1.0922867893808 5.63754607494775e-06 -0.158206463549222 0.788653403324686 miRanda -0.563227706635046 3.8849947241766e-07 NA NA NA hsa-miR-149-5p PAK3 -0.185943525121015 0.638713382556459 -0.158206463549222 0.788653403324686 MirTarget;miRNATAP -0.186763697255916 0.00645718443635954 NA NA NA hsa-miR-23a-3p PAK3 0.111958289789488 0.393086414480463 -0.158206463549222 0.788653403324686 MirTarget -0.435032868354217 0.039584618006952 NA NA NA hsa-miR-361-5p PAK3 0.21454431962475 0.0800957579368424 -0.158206463549222 0.788653403324686 miRanda -0.763789677434406 0.000709446273535441 NA NA NA hsa-miR-362-5p PAK3 0.658947634569393 0.0243306847205756 -0.158206463549222 0.788653403324686 TargetScan -0.440325579802888 3.13011501097875e-06 NA NA NA hsa-miR-590-3p PAK3 0.83851360565783 0.00129224433453587 -0.158206463549222 0.788653403324686 miRanda -0.335743438017127 0.00714410858129786 NA NA NA hsa-miR-590-5p PAK3 2.07441240363458 4.95240551694843e-14 -0.158206463549222 0.788653403324686 miRanda -0.361123491367549 0.0024338558008885 NA NA NA hsa-let-7c-5p PAK4 -2.14139413005852 1.66416999341685e-18 -0.0564659247633852 0.687074119906002 miRNAWalker2_validate -0.114500014049037 5.65159225611115e-06 NA NA NA hsa-miR-193a-3p PAK6 0.549173467360291 0.0319030569365466 0.857599303522948 1.69158498437245e-05 miRanda -0.157112383007479 5.82104827782952e-05 NA NA NA hsa-miR-23a-3p PAK6 0.111958289789488 0.393086414480463 0.857599303522948 1.69158498437245e-05 miRNATAP -0.14261624864952 0.0476349551742274 25714010 Downregulation of microRNA 23a suppresses prostate cancer metastasis by targeting the PAK6 LIMK1 signaling pathway; MiR-23a decreased levels of p21-activated kinase 6 PAK6 metastasis prostate cancer hsa-miR-484 PAK6 -0.228576985124486 0.244112867390855 0.857599303522948 1.69158498437245e-05 mirMAP -0.14662584494854 0.00197081929822017 NA NA NA hsa-miR-450a-5p PBX1 1.94284269183615 1.52883075909271e-07 -1.07873775062477 2.94362106445457e-05 miRNATAP -0.112757775208192 0.00312462313106731 NA NA NA hsa-miR-335-3p PDGFA 1.51116383169018 6.88553098788624e-13 -1.02357928315978 6.32690913682403e-05 mirMAP -0.248081383651425 5.98335990526186e-06 NA NA NA hsa-miR-421 PDGFA 0.170525317701774 0.535277026680289 -1.02357928315978 6.32690913682403e-05 miRanda -0.246541712884684 1.12589234652839e-07 NA NA NA hsa-miR-576-5p PDGFA 1.02693643167056 1.14846964470173e-06 -1.02357928315978 6.32690913682403e-05 mirMAP -0.200616922001446 0.000312414801468213 NA NA NA hsa-miR-590-3p PDGFA 0.83851360565783 0.00129224433453587 -1.02357928315978 6.32690913682403e-05 miRanda -0.159499365763311 0.00342016098327547 NA NA NA hsa-miR-590-5p PDGFA 2.07441240363458 4.95240551694843e-14 -1.02357928315978 6.32690913682403e-05 miRanda -0.168569970910494 0.00119006900103511 NA NA NA hsa-let-7f-5p PDGFB -0.0523311272618407 0.83407808268787 -1.57245721400853 2.64510689458541e-14 miRNATAP -0.111940449788439 0.00438563718329827 NA NA NA hsa-let-7g-5p PDGFB 0.0837630831079359 0.583083118232597 -1.57245721400853 2.64510689458541e-14 miRNATAP -0.144578059149773 0.0262453686859633 NA NA NA hsa-let-7i-5p PDGFB 0.605080599172936 1.48406814653206e-06 -1.57245721400853 2.64510689458541e-14 miRNATAP -0.166250927487447 0.0343790960424421 NA NA NA hsa-miR-17-5p PDGFB 2.07078488653279 2.77403038572568e-19 -1.57245721400853 2.64510689458541e-14 TargetScan -0.128759642118731 0.00159228819466453 NA NA NA hsa-miR-26b-5p PDGFB 0.72362441215247 4.7794659748036e-05 -1.57245721400853 2.64510689458541e-14 miRNAWalker2_validate -0.115611436001545 0.035831003112231 NA NA NA hsa-miR-29b-3p PDGFB 3.10527711861309 3.01242507282711e-32 -1.57245721400853 2.64510689458541e-14 MirTarget;miRNATAP -0.163569333467524 2.06968288487126e-06 NA NA NA hsa-miR-29c-3p PDGFB 1.32354490728858 1.84279305179762e-07 -1.57245721400853 2.64510689458541e-14 MirTarget;miRNATAP -0.160756497303994 2.23137768074853e-05 NA NA NA hsa-miR-16-2-3p PDGFC 0.503964803530872 0.0263648405197492 0.0233013874637775 0.91191903726111 mirMAP -0.175472011716023 0.000148127034743397 NA NA NA hsa-miR-330-5p PDGFC 0.168520831101569 0.336433937906706 0.0233013874637775 0.91191903726111 miRanda -0.205297704063843 0.000217928347062889 NA NA NA hsa-miR-335-3p PDGFC 1.51116383169018 6.88553098788624e-13 0.0233013874637775 0.91191903726111 mirMAP -0.194216460665665 1.42381995093366e-05 NA NA NA hsa-miR-375 PDGFC 0.615547997686534 0.149199273675144 0.0233013874637775 0.91191903726111 miRNAWalker2_validate;miRanda -0.11262292290509 5.19364391065989e-07 NA NA NA hsa-miR-421 PDGFC 0.170525317701774 0.535277026680289 0.0233013874637775 0.91191903726111 miRanda -0.110316895438161 0.00398916648118102 NA NA NA hsa-miR-7-1-3p PDGFC 2.61364240402652 1.98959237815786e-32 0.0233013874637775 0.91191903726111 mirMAP -0.109406443830704 0.0114583818231913 NA NA NA hsa-miR-7-5p PDGFC 0.343825848926135 0.435063427976906 0.0233013874637775 0.91191903726111 miRNAWalker2_validate -0.102774651199499 0.000171471393112032 NA NA NA hsa-miR-125a-3p PDGFD -1.04954492275266 2.45974219476832e-06 -0.036065387819836 0.899942301493889 miRanda -0.125784103375131 0.0327119988365424 NA NA NA hsa-miR-19b-1-5p PDGFD 1.71217036351784 3.28561659177495e-12 -0.036065387819836 0.899942301493889 MirTarget -0.186814465461764 0.00206415431431943 NA NA NA hsa-miR-203a-3p PDGFD 1.06866854356847 0.00389979689199624 -0.036065387819836 0.899942301493889 MirTarget -0.153007127618089 1.43396888679748e-05 NA NA NA hsa-miR-320a PDGFD -0.961144925954715 1.62478794429204e-08 -0.036065387819836 0.899942301493889 miRanda -0.189771049670532 0.0137488766644769 NA NA NA hsa-miR-320b PDGFD 0.226640952564488 0.378818692487242 -0.036065387819836 0.899942301493889 miRanda -0.183329766510607 0.000344170753203176 NA NA NA hsa-miR-331-5p PDGFD 0.578237334664505 0.00131211239210882 -0.036065387819836 0.899942301493889 MirTarget -0.292523098930857 9.99729887527437e-05 NA NA NA hsa-miR-335-3p PDGFD 1.51116383169018 6.88553098788624e-13 -0.036065387819836 0.899942301493889 mirMAP -0.154469187541404 0.0118560808829275 NA NA NA hsa-miR-590-3p PDGFD 0.83851360565783 0.00129224433453587 -0.036065387819836 0.899942301493889 miRanda;mirMAP;miRNATAP -0.183648734809027 0.00242354761671291 NA NA NA hsa-miR-590-5p PDGFD 2.07441240363458 4.95240551694843e-14 -0.036065387819836 0.899942301493889 miRanda -0.233999181813206 4.90533045333196e-05 NA NA NA hsa-miR-7-1-3p PDGFD 2.61364240402652 1.98959237815786e-32 -0.036065387819836 0.899942301493889 mirMAP -0.292442744010984 5.45899275446096e-07 NA NA NA hsa-let-7g-3p PDGFRA 2.38336858943031 4.8771148585792e-17 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.123737451095322 0.00243922499879256 NA NA NA hsa-miR-106a-5p PDGFRA 1.3902608059488 6.07931522284525e-05 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.262061462129381 3.43080881453501e-12 NA NA NA hsa-miR-106b-5p PDGFRA 1.47447672652218 1.32004094930462e-13 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.437339015207479 2.74054790375275e-14 NA NA NA hsa-miR-130b-3p PDGFRA 1.83046548750752 5.04753914574694e-13 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.228770191152218 2.33154390281087e-06 NA NA NA hsa-miR-141-3p PDGFRA 3.36993755486106 5.42939251147195e-32 -0.920353534269053 0.00039437071007992 MirTarget -0.32772250053676 4.14560711921769e-18 NA NA NA hsa-miR-16-1-3p PDGFRA 1.50034693398929 6.63958242991125e-10 -0.920353534269053 0.00039437071007992 MirTarget -0.392102224483284 4.01359006065225e-11 NA NA NA hsa-miR-17-5p PDGFRA 2.07078488653279 2.77403038572568e-19 -0.920353534269053 0.00039437071007992 MirTarget;TargetScan;miRNATAP -0.437831726557654 1.09121275373163e-19 NA NA NA hsa-miR-181b-5p PDGFRA 0.668793269169928 0.000239998092406404 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.243346668635648 0.000221056637302438 NA NA NA hsa-miR-182-5p PDGFRA 3.21839823004635 5.13049145201115e-39 -0.920353534269053 0.00039437071007992 miRNATAP -0.228069978604342 2.76628203495785e-07 NA NA NA hsa-miR-186-5p PDGFRA 0.852175445703945 6.88885738584309e-10 -0.920353534269053 0.00039437071007992 MirTarget -0.444642699585465 2.17102227065078e-07 NA NA NA hsa-miR-200a-3p PDGFRA 3.14766878548496 1.32850889777422e-21 -0.920353534269053 0.00039437071007992 MirTarget -0.223485348461317 1.8870643178893e-10 NA NA NA hsa-miR-20a-5p PDGFRA 2.64649625616975 5.1469418982085e-27 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.375839309283569 3.9000709448395e-17 NA NA NA hsa-miR-20b-5p PDGFRA 1.35770573270947 0.00260808530013016 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.125923024866371 5.86457189774267e-06 NA NA NA hsa-miR-26b-5p PDGFRA 0.72362441215247 4.7794659748036e-05 -0.920353534269053 0.00039437071007992 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.299986293654127 7.81964761899525e-06 NA NA NA hsa-miR-29b-1-5p PDGFRA 1.71024742617744 3.64915691793611e-09 -0.920353534269053 0.00039437071007992 mirMAP -0.203385697475619 4.80726047062849e-07 NA NA NA hsa-miR-29b-2-5p PDGFRA 0.345881055247341 0.194842633194187 -0.920353534269053 0.00039437071007992 mirMAP -0.10277633206335 0.0229669323509369 NA NA NA hsa-miR-29b-3p PDGFRA 3.10527711861309 3.01242507282711e-32 -0.920353534269053 0.00039437071007992 MirTarget -0.210988079915463 6.03805137676526e-07 NA NA NA hsa-miR-301a-3p PDGFRA 2.70198002906399 1.56420889710984e-14 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.242329454445345 2.28119446181804e-09 NA NA NA hsa-miR-3065-5p PDGFRA 0.653308707552535 0.0999497219778851 -0.920353534269053 0.00039437071007992 mirMAP -0.145680616077162 8.34288503273181e-06 NA NA NA hsa-miR-335-3p PDGFRA 1.51116383169018 6.88553098788624e-13 -0.920353534269053 0.00039437071007992 mirMAP -0.345739811848265 3.1636014257612e-10 NA NA NA hsa-miR-338-3p PDGFRA 0.726843067232002 0.0506251324215494 -0.920353534269053 0.00039437071007992 miRanda -0.106588181578414 0.000936971496448231 NA NA NA hsa-miR-339-5p PDGFRA 0.536997313601114 0.0488090394176611 -0.920353534269053 0.00039437071007992 miRanda -0.191797874450638 1.22262689505586e-05 NA NA NA hsa-miR-33a-5p PDGFRA 2.80127809675219 5.09053890529424e-12 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.207468703325488 4.3541979242939e-09 NA NA NA hsa-miR-34a-5p PDGFRA 1.40588612517769 8.60097477768592e-12 -0.920353534269053 0.00039437071007992 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.210491527503148 0.000228547067911926 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-362-3p PDGFRA 0.194097672030785 0.52808475179225 -0.920353534269053 0.00039437071007992 miRanda -0.195936237894039 5.79891842116764e-05 NA NA NA hsa-miR-421 PDGFRA 0.170525317701774 0.535277026680289 -0.920353534269053 0.00039437071007992 PITA;miRanda;miRNATAP -0.173891582150038 0.000247812525545878 NA NA NA hsa-miR-429 PDGFRA 2.3794516574089 1.72813419703734e-13 -0.920353534269053 0.00039437071007992 miRanda;miRNATAP -0.246006444903332 1.87540030422368e-10 NA NA NA hsa-miR-450b-5p PDGFRA 1.69248953402469 1.96052058003353e-07 -0.920353534269053 0.00039437071007992 mirMAP -0.122074687915198 0.00275129796040725 NA NA NA hsa-miR-454-3p PDGFRA 1.49453641052169 4.46235742871434e-09 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.418333685525631 1.11010754867789e-14 NA NA NA hsa-miR-576-5p PDGFRA 1.02693643167056 1.14846964470173e-06 -0.920353534269053 0.00039437071007992 mirMAP -0.298051358520212 9.84291671920344e-08 NA NA NA hsa-miR-589-3p PDGFRA 1.34253876396688 1.84935927493927e-05 -0.920353534269053 0.00039437071007992 mirMAP -0.134517057854286 0.000597797805674663 NA NA NA hsa-miR-590-3p PDGFRA 0.83851360565783 0.00129224433453587 -0.920353534269053 0.00039437071007992 miRanda;mirMAP -0.215815523135662 8.72132841756153e-05 NA NA NA hsa-miR-590-5p PDGFRA 2.07441240363458 4.95240551694843e-14 -0.920353534269053 0.00039437071007992 miRanda -0.320495725599276 6.72663827937009e-10 NA NA NA hsa-miR-664a-3p PDGFRA 0.443077463053857 0.0214248925850984 -0.920353534269053 0.00039437071007992 mirMAP -0.129557176287868 0.0391289823486743 NA NA NA hsa-miR-7-1-3p PDGFRA 2.61364240402652 1.98959237815786e-32 -0.920353534269053 0.00039437071007992 mirMAP -0.280823951585571 1.24689968872089e-07 NA NA NA hsa-miR-93-5p PDGFRA 1.50844106515467 1.83836866996875e-12 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.429749525450464 7.91013052237628e-16 NA NA NA hsa-miR-96-5p PDGFRA 3.0381097138467 4.40362891630201e-24 -0.920353534269053 0.00039437071007992 TargetScan;miRNATAP -0.313559555428942 2.60827207243362e-13 NA NA NA hsa-miR-28-5p PDGFRB 1.19639196514745 4.59365801666536e-18 -0.472627234019869 0.0195049282675806 miRanda -0.160001911510344 0.0153061011931282 NA NA NA hsa-miR-29b-3p PDGFRB 3.10527711861309 3.01242507282711e-32 -0.472627234019869 0.0195049282675806 miRNATAP -0.101003962314959 0.00225724349565461 NA NA NA hsa-miR-3127-5p PDGFRB 0.382717393698386 0.11535780874721 -0.472627234019869 0.0195049282675806 mirMAP -0.153147342374875 6.32703967379545e-05 NA NA NA hsa-miR-421 PDGFRB 0.170525317701774 0.535277026680289 -0.472627234019869 0.0195049282675806 miRanda -0.182914387101734 5.73372143884839e-07 NA NA NA hsa-miR-194-5p PER3 1.76979641760284 8.2064222072696e-05 -0.595412479621491 0.0348375134144613 miRNATAP -0.131095319441781 4.1726105135315e-06 NA NA NA hsa-miR-146b-5p PGF 1.0922867893808 5.63754607494775e-06 0.777631755389818 0.00433016067358226 miRanda -0.123674254078055 0.0173831758596673 NA NA NA hsa-miR-335-5p PGF -0.466533891325811 0.0676987038122831 0.777631755389818 0.00433016067358226 miRNATAP -0.119665162525165 0.0306179315192342 NA NA NA hsa-miR-186-5p PIK3CA 0.852175445703945 6.88885738584309e-10 -0.335143841150832 0.0107695904000801 mirMAP -0.158211833933772 0.000271764939125213 NA NA NA hsa-miR-501-5p PIK3CA 0.411357595674671 0.10435288464149 -0.335143841150832 0.0107695904000801 mirMAP -0.12161859871495 2.80222388365699e-07 NA NA NA hsa-miR-96-5p PIK3CA 3.0381097138467 4.40362891630201e-24 -0.335143841150832 0.0107695904000801 TargetScan -0.126074442438012 7.26672594996813e-09 NA NA NA hsa-miR-454-3p PIK3CB 1.49453641052169 4.46235742871434e-09 0.0520424688078016 0.708498300848208 miRNATAP -0.107092855274913 0.000279808925292599 NA NA NA hsa-miR-421 PIK3CD 0.170525317701774 0.535277026680289 -0.165252183051274 0.400815192488832 miRanda -0.187035284767016 1.2803934448503e-07 NA NA NA hsa-miR-106a-5p PIK3R1 1.3902608059488 6.07931522284525e-05 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.152594260668069 8.26964346589391e-10 NA NA NA hsa-miR-106b-5p PIK3R1 1.47447672652218 1.32004094930462e-13 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.274486784039244 3.92361901886501e-13 NA NA NA hsa-miR-107 PIK3R1 0.658676029898313 5.11480446318819e-07 -1.28526113405546 1.1596112892202e-14 MirTarget;PITA;miRanda;miRNATAP -0.134608742116129 0.0261488734968106 NA NA NA hsa-miR-128-3p PIK3R1 1.03509868349735 2.11606310588315e-10 -1.28526113405546 1.1596112892202e-14 MirTarget -0.262733562571172 2.81828198129055e-08 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 0.845987603184611 0.000579808501723616 -1.28526113405546 1.1596112892202e-14 MirTarget -0.252566507630763 3.89638206850943e-16 NA NA NA hsa-miR-15a-5p PIK3R1 1.62575353599172 1.55312121019827e-19 -1.28526113405546 1.1596112892202e-14 MirTarget -0.198845640675418 2.2459439580454e-06 NA NA NA hsa-miR-16-2-3p PIK3R1 0.503964803530872 0.0263648405197492 -1.28526113405546 1.1596112892202e-14 MirTarget -0.215346374588015 7.85659740371802e-09 NA NA NA hsa-miR-16-5p PIK3R1 0.749619098384047 4.11649450706988e-06 -1.28526113405546 1.1596112892202e-14 MirTarget -0.14663084031301 0.00245632583144358 NA NA NA hsa-miR-17-5p PIK3R1 2.07078488653279 2.77403038572568e-19 -1.28526113405546 1.1596112892202e-14 MirTarget;TargetScan;miRNATAP -0.30827377198364 1.00416866782136e-22 NA NA NA hsa-miR-182-5p PIK3R1 3.21839823004635 5.13049145201115e-39 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.153577568348738 1.31399000956901e-07 NA NA NA hsa-miR-185-5p PIK3R1 1.14291034858482 2.95777119743491e-13 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.266123472564886 5.49627003455298e-08 NA NA NA hsa-miR-186-5p PIK3R1 0.852175445703945 6.88885738584309e-10 -1.28526113405546 1.1596112892202e-14 mirMAP -0.266496146428416 2.3226235073163e-06 NA NA NA hsa-miR-200c-3p PIK3R1 0.380533388300368 0.0842181838538353 -1.28526113405546 1.1596112892202e-14 mirMAP -0.174738637328334 9.22364461849854e-07 NA NA NA hsa-miR-20a-5p PIK3R1 2.64649625616975 5.1469418982085e-27 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.268255645046992 2.93530513676098e-20 NA NA NA hsa-miR-21-5p PIK3R1 4.38165933891779 1.52536633902505e-92 -1.28526113405546 1.1596112892202e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.239855941401679 1.66617444081141e-16 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 1.71436244278242 9.85038001236064e-15 -1.28526113405546 1.1596112892202e-14 mirMAP -0.249170402831725 1.77307790115702e-13 NA NA NA hsa-miR-29b-3p PIK3R1 3.10527711861309 3.01242507282711e-32 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.169264704761152 8.1620915503371e-10 NA NA NA hsa-miR-335-3p PIK3R1 1.51116383169018 6.88553098788624e-13 -1.28526113405546 1.1596112892202e-14 mirMAP -0.174731000503181 1.56931158200611e-06 NA NA NA hsa-miR-424-5p PIK3R1 1.26485330287919 6.1498991028257e-06 -1.28526113405546 1.1596112892202e-14 MirTarget -0.120660860108298 1.41199550729587e-05 NA NA NA hsa-miR-450b-5p PIK3R1 1.69248953402469 1.96052058003353e-07 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.105483872062601 7.60035078150308e-05 NA NA NA hsa-miR-582-5p PIK3R1 1.08286181406653 0.00149040450161757 -1.28526113405546 1.1596112892202e-14 mirMAP -0.121659359408152 1.98808465862233e-07 NA NA NA hsa-miR-589-3p PIK3R1 1.34253876396688 1.84935927493927e-05 -1.28526113405546 1.1596112892202e-14 mirMAP -0.110115880585781 1.73041185531321e-05 NA NA NA hsa-miR-590-3p PIK3R1 0.83851360565783 0.00129224433453587 -1.28526113405546 1.1596112892202e-14 miRanda;mirMAP -0.21433969556349 1.93094554722457e-09 NA NA NA hsa-miR-590-5p PIK3R1 2.07441240363458 4.95240551694843e-14 -1.28526113405546 1.1596112892202e-14 MirTarget;PITA;miRanda;miRNATAP -0.297606057222883 4.39734655384069e-19 NA NA NA hsa-miR-629-3p PIK3R1 1.31892116211001 0.000114487182853678 -1.28526113405546 1.1596112892202e-14 MirTarget -0.155200085033098 2.2200629415611e-10 NA NA NA hsa-miR-93-5p PIK3R1 1.50844106515467 1.83836866996875e-12 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.302548872464343 3.62432128460294e-18 NA NA NA hsa-miR-96-5p PIK3R1 3.0381097138467 4.40362891630201e-24 -1.28526113405546 1.1596112892202e-14 TargetScan;miRNATAP -0.247820034174453 4.28366535969023e-19 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.71024742617744 3.64915691793611e-09 -0.993075734580867 1.37876508579496e-06 mirMAP -0.137607471527013 2.02669327816331e-05 NA NA NA hsa-miR-335-3p PIK3R3 1.51116383169018 6.88553098788624e-13 -0.993075734580867 1.37876508579496e-06 mirMAP -0.239450639911665 5.21180596069304e-08 NA NA NA hsa-miR-324-5p PLA1A 1.06955541886548 5.39722006604758e-05 -1.82278067926863 2.2692334563848e-07 miRanda -0.13831515852741 0.0251037159941524 NA NA NA hsa-miR-142-5p PLA2G12A 1.29672439149353 4.0768822158894e-06 -0.0788546181881973 0.499158564786441 mirMAP -0.131800396566356 4.84970998647658e-11 NA NA NA hsa-miR-150-5p PLA2G12A -0.702328520623782 0.0215316651134431 -0.0788546181881973 0.499158564786441 mirMAP -0.109476263552952 1.80094060108042e-10 NA NA NA hsa-miR-28-5p PLA2G1B 1.19639196514745 4.59365801666536e-18 -4.65869434494303 5.92632211074147e-12 miRanda -0.714163430019852 0.00154176723606543 NA NA NA hsa-miR-361-5p PLA2G2A 0.21454431962475 0.0800957579368424 -2.28008503185378 0.000145863257153751 miRanda -0.555826622229242 0.0165493751978908 NA NA NA hsa-miR-432-5p PLA2G2D -0.308818761349565 0.414172181069431 1.2831755733228 0.0119582527429079 mirMAP -0.137690274984799 0.031939757857889 NA NA NA hsa-miR-1976 PLA2G2F -1.27772236648866 7.13245221784788e-10 1.85239250918301 0.000408421370733288 mirMAP -0.412433519219505 0.000339748244121928 NA NA NA hsa-miR-324-3p PLA2G2F -0.0774700133118458 0.689226297032231 1.85239250918301 0.000408421370733288 mirMAP -0.305242523385136 0.0156797886273138 NA NA NA hsa-miR-484 PLA2G2F -0.228576985124486 0.244112867390855 1.85239250918301 0.000408421370733288 mirMAP -0.246120463510952 0.048456880319733 NA NA NA hsa-miR-532-3p PLA2G2F -0.677758187385834 0.0147557885796065 1.85239250918301 0.000408421370733288 mirMAP -0.180902222675426 0.0384991747781256 NA NA NA hsa-miR-532-5p PLA2G2F 0.576620898517708 0.0023245812680956 1.85239250918301 0.000408421370733288 mirMAP -0.384692781015398 0.00274632142999211 NA NA NA hsa-miR-450b-5p PLA2G3 1.69248953402469 1.96052058003353e-07 -3.26398420302921 7.81993892455061e-08 miRNATAP -0.430421579056939 6.90748646882128e-06 NA NA NA hsa-miR-452-3p PLA2G3 0.477736876273128 0.22218404598603 -3.26398420302921 7.81993892455061e-08 MirTarget -0.255221077598253 0.00248457917549569 NA NA NA hsa-miR-139-5p PLA2G4A -2.26625553116965 7.22375119369519e-16 1.23139708452911 0.00360064815222154 miRanda -0.164857799399304 0.0145088617499985 NA NA NA hsa-miR-146b-5p PLA2G4A 1.0922867893808 5.63754607494775e-06 1.23139708452911 0.00360064815222154 miRNAWalker2_validate -0.539646016767087 8.49384554342977e-12 NA NA NA hsa-miR-30a-5p PLA2G4A -0.924084264430689 0.000762030454634728 1.23139708452911 0.00360064815222154 miRNAWalker2_validate -0.337988397444713 1.56392399647892e-06 NA NA NA hsa-miR-361-5p PLA2G4A 0.21454431962475 0.0800957579368424 1.23139708452911 0.00360064815222154 miRanda -0.455000317938252 0.005160776853399 NA NA NA hsa-miR-362-3p PLA2G4A 0.194097672030785 0.52808475179225 1.23139708452911 0.00360064815222154 miRanda -0.171453837499879 0.0315287026338848 NA NA NA hsa-miR-374a-5p PLA2G4A -0.197027254874826 0.298080902192861 1.23139708452911 0.00360064815222154 mirMAP -0.384602231876405 0.000945916552995376 NA NA NA hsa-miR-107 PLA2G4C 0.658676029898313 5.11480446318819e-07 -1.24178220482855 2.52386450203673e-06 miRanda -0.394494491258751 2.47315372686841e-05 NA NA NA hsa-miR-193a-3p PLA2G4D 0.549173467360291 0.0319030569365466 1.18162388045427 0.00366266783250765 miRanda -0.307433745476107 0.000109041821830572 NA NA NA hsa-miR-450b-5p PLA2G4E 1.69248953402469 1.96052058003353e-07 -0.723776164951995 0.201279307414008 mirMAP -0.353591315163214 6.01448410118293e-05 NA NA NA hsa-miR-10a-5p PLA2G4F 0.790595816051606 0.000593731378445468 -3.56034144212079 3.91935551942517e-15 miRNAWalker2_validate -0.243898198081826 0.00903981235964838 NA NA NA hsa-miR-331-3p PLA2G4F 0.648841966086413 0.00576420872256978 -3.56034144212079 3.91935551942517e-15 miRNAWalker2_validate -0.257722262169358 0.00491795258692222 NA NA NA hsa-miR-128-3p PLA2G5 1.03509868349735 2.11606310588315e-10 -1.52854910719925 3.60899705613865e-08 miRNAWalker2_validate -0.463850459902729 2.23760548419397e-09 NA NA NA hsa-miR-330-5p PLA2G5 0.168520831101569 0.336433937906706 -1.52854910719925 3.60899705613865e-08 miRanda -0.308708237234084 3.20106460280176e-05 NA NA NA hsa-miR-361-5p PLA2G5 0.21454431962475 0.0800957579368424 -1.52854910719925 3.60899705613865e-08 miRanda -0.251832084398457 0.0197645868459458 NA NA NA hsa-miR-429 PLA2G5 2.3794516574089 1.72813419703734e-13 -1.52854910719925 3.60899705613865e-08 miRanda -0.178077576146297 2.39509849764538e-05 NA NA NA hsa-miR-590-5p PLA2G5 2.07441240363458 4.95240551694843e-14 -1.52854910719925 3.60899705613865e-08 miRanda -0.21637478398772 0.000135984222229852 NA NA NA hsa-miR-185-3p PLA2G6 -0.377490365509078 0.093653288903368 0.476315859876846 0.0705352394789323 MirTarget -0.267493284551792 5.88524200603373e-07 NA NA NA hsa-miR-30a-3p PLA2G6 -2.54042202792785 2.9111625410859e-18 0.476315859876846 0.0705352394789323 miRNATAP -0.146668786631899 0.000240180915888741 NA NA NA hsa-miR-423-5p PLA2G6 -1.80309342242719 1.34791344187441e-19 0.476315859876846 0.0705352394789323 MirTarget;miRNATAP -0.232289362179402 7.11654533343099e-05 NA NA NA hsa-miR-324-5p PLCE1 1.06955541886548 5.39722006604758e-05 -1.93253134423055 7.73138621481009e-12 miRanda -0.132832780656625 0.00785965189136968 NA NA NA hsa-miR-96-5p PLCE1 3.0381097138467 4.40362891630201e-24 -1.93253134423055 7.73138621481009e-12 TargetScan -0.284470925293489 2.95891239908821e-09 NA NA NA hsa-miR-15a-5p PLD1 1.62575353599172 1.55312121019827e-19 -0.0927976741742502 0.632163857168506 MirTarget -0.186716319377354 8.89752659769066e-05 NA NA NA hsa-miR-16-5p PLD1 0.749619098384047 4.11649450706988e-06 -0.0927976741742502 0.632163857168506 MirTarget -0.127895097556896 0.019546686618304 NA NA NA hsa-miR-335-3p PLD1 1.51116383169018 6.88553098788624e-13 -0.0927976741742502 0.632163857168506 mirMAP -0.105465494605042 0.0109441361843304 NA NA NA hsa-miR-455-5p PLD1 1.36946341828134 5.05118627562807e-08 -0.0927976741742502 0.632163857168506 miRanda -0.164844268727997 4.28906360652031e-05 NA NA NA hsa-miR-497-5p PLD1 -0.0546347378264729 0.786205564901684 -0.0927976741742502 0.632163857168506 MirTarget -0.120428884701124 0.00682452795404575 NA NA NA hsa-miR-664a-3p PLD1 0.443077463053857 0.0214248925850984 -0.0927976741742502 0.632163857168506 mirMAP -0.186377452836656 5.56423123395291e-05 NA NA NA hsa-miR-96-5p PLD1 3.0381097138467 4.40362891630201e-24 -0.0927976741742502 0.632163857168506 miRNATAP -0.110274633163693 0.000687056835269487 NA NA NA hsa-miR-450a-5p PLXNA2 1.94284269183615 1.52883075909271e-07 -1.1615915565644 1.97317825006664e-05 MirTarget -0.175635656444012 1.13657223979178e-05 NA NA NA hsa-miR-194-5p PRICKLE2 1.76979641760284 8.2064222072696e-05 -1.56077600074788 2.11863685620441e-14 miRNATAP -0.100005981312587 2.34509042318743e-06 NA NA NA hsa-let-7a-3p PRKACB 0.167285443861993 0.431834813181487 -0.337490057919314 0.0956151593593903 MirTarget;mirMAP;miRNATAP -0.109621340434496 0.0264314696722877 NA NA NA hsa-miR-141-3p PRKACB 3.36993755486106 5.42939251147195e-32 -0.337490057919314 0.0956151593593903 MirTarget;TargetScan;miRNATAP -0.127873218774198 2.27329955972899e-05 NA NA NA hsa-miR-146b-5p PRKACB 1.0922867893808 5.63754607494775e-06 -0.337490057919314 0.0956151593593903 miRanda -0.16173584971976 2.34820463010476e-05 NA NA NA hsa-miR-16-2-3p PRKACB 0.503964803530872 0.0263648405197492 -0.337490057919314 0.0956151593593903 mirMAP -0.126437256197819 0.00465216057285952 NA NA NA hsa-miR-17-5p PRKACB 2.07078488653279 2.77403038572568e-19 -0.337490057919314 0.0956151593593903 TargetScan -0.146235921583623 0.000160820334409303 NA NA NA hsa-miR-182-5p PRKACB 3.21839823004635 5.13049145201115e-39 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.112248448456467 0.00121734908239389 NA NA NA hsa-miR-183-5p PRKACB 2.39247234736657 3.92444525331999e-21 -0.337490057919314 0.0956151593593903 MirTarget -0.10185724563834 0.0037757174706069 NA NA NA hsa-miR-19a-3p PRKACB 2.11776595911517 7.07663078397156e-10 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.170735517959884 5.74076627300856e-08 NA NA NA hsa-miR-19b-3p PRKACB 2.10868505662119 5.40846613768389e-17 -0.337490057919314 0.0956151593593903 miRNAWalker2_validate;MirTarget;miRNATAP -0.197277470144974 1.27039043015725e-07 NA NA NA hsa-miR-200b-3p PRKACB 1.55157578247391 4.83790020897188e-09 -0.337490057919314 0.0956151593593903 MirTarget;TargetScan -0.101454883897731 0.00336247964553013 NA NA NA hsa-miR-200c-3p PRKACB 0.380533388300368 0.0842181838538353 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.115374415768757 0.00655504187350906 NA NA NA hsa-miR-339-5p PRKACB 0.536997313601114 0.0488090394176611 -0.337490057919314 0.0956151593593903 miRanda -0.172209477372762 3.7061891291678e-07 NA NA NA hsa-miR-34a-5p PRKACB 1.40588612517769 8.60097477768592e-12 -0.337490057919314 0.0956151593593903 miRNATAP -0.249544715069385 1.25392359331725e-08 NA NA NA hsa-miR-362-5p PRKACB 0.658947634569393 0.0243306847205756 -0.337490057919314 0.0956151593593903 PITA -0.152310553896922 2.5944554975563e-06 NA NA NA hsa-miR-429 PRKACB 2.3794516574089 1.72813419703734e-13 -0.337490057919314 0.0956151593593903 MirTarget;PITA;miRanda;miRNATAP -0.120289214888389 7.31299726157361e-05 NA NA NA hsa-miR-590-5p PRKACB 2.07441240363458 4.95240551694843e-14 -0.337490057919314 0.0956151593593903 miRanda -0.106057390676399 0.00956598336443456 NA NA NA hsa-miR-93-5p PRKACB 1.50844106515467 1.83836866996875e-12 -0.337490057919314 0.0956151593593903 miRNAWalker2_validate -0.173603248772151 4.27230598908178e-05 NA NA NA hsa-miR-96-5p PRKACB 3.0381097138467 4.40362891630201e-24 -0.337490057919314 0.0956151593593903 miRNATAP -0.19117539499709 1.28710220181067e-08 NA NA NA hsa-miR-17-3p PRKCA 1.36706429551147 4.60388403547821e-13 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.2211557176846 0.000413342702730225 NA NA NA hsa-miR-181c-5p PRKCA 0.529875814537156 0.0125885822998008 -0.189679589892687 0.471078192212991 mirMAP -0.326745565499583 6.66432412436314e-09 NA NA NA hsa-miR-183-5p PRKCA 2.39247234736657 3.92444525331999e-21 -0.189679589892687 0.471078192212991 miRNATAP -0.191021307259656 2.63755654536705e-05 NA NA NA hsa-miR-186-5p PRKCA 0.852175445703945 6.88885738584309e-10 -0.189679589892687 0.471078192212991 miRNATAP -0.182809848844304 0.0364827269657349 NA NA NA hsa-miR-193b-3p PRKCA 1.10444771306846 0.000822888533401377 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.138487066621768 0.000138664149309437 NA NA NA hsa-miR-193b-5p PRKCA 0.179695858885499 0.55521472494233 -0.189679589892687 0.471078192212991 mirMAP -0.137899397693864 0.000521039895191079 NA NA NA hsa-miR-19b-1-5p PRKCA 1.71217036351784 3.28561659177495e-12 -0.189679589892687 0.471078192212991 mirMAP -0.210975845049586 0.000143708055393517 NA NA NA hsa-miR-200b-3p PRKCA 1.55157578247391 4.83790020897188e-09 -0.189679589892687 0.471078192212991 TargetScan -0.1088658423995 0.0155570891072353 NA NA NA hsa-miR-200c-3p PRKCA 0.380533388300368 0.0842181838538353 -0.189679589892687 0.471078192212991 miRNATAP -0.262911308228053 1.5097135867061e-06 NA NA NA hsa-miR-22-5p PRKCA 1.71436244278242 9.85038001236064e-15 -0.189679589892687 0.471078192212991 mirMAP -0.177526746625668 0.000829577475678236 NA NA NA hsa-miR-24-2-5p PRKCA 1.43704663046967 4.34375016509278e-11 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.114268570782096 0.0364691635457816 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-429 PRKCA 2.3794516574089 1.72813419703734e-13 -0.189679589892687 0.471078192212991 miRanda;miRNATAP -0.142853746691809 0.000293353456114152 NA NA NA hsa-miR-590-3p PRKCA 0.83851360565783 0.00129224433453587 -0.189679589892687 0.471078192212991 PITA;miRanda;mirMAP;miRNATAP -0.19448195031258 0.000455368438666445 NA NA NA hsa-miR-92a-3p PRKCA -0.136362762339122 0.493412263619364 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.160805726714066 0.00861285946041943 NA NA NA hsa-miR-93-3p PRKCA 1.07631808403007 1.63747525692813e-05 -0.189679589892687 0.471078192212991 mirMAP -0.159060267220526 0.000935006714973491 NA NA NA hsa-miR-141-5p PRKCB 3.02575703771074 1.54385222591327e-32 -1.01521651364956 0.000234705382361064 mirMAP -0.19965194499171 1.76112086865619e-05 NA NA NA hsa-miR-200b-3p PRKCB 1.55157578247391 4.83790020897188e-09 -1.01521651364956 0.000234705382361064 MirTarget -0.139521777238666 0.00328113460432514 NA NA NA hsa-miR-200c-3p PRKCB 0.380533388300368 0.0842181838538353 -1.01521651364956 0.000234705382361064 MirTarget;miRNATAP -0.217004467533231 0.000183295321414174 NA NA NA hsa-miR-24-3p PRKCB -0.0357874587555003 0.785865078836504 -1.01521651364956 0.000234705382361064 miRNATAP -0.200930519007703 0.0424759197567277 NA NA NA hsa-miR-335-3p PRKCB 1.51116383169018 6.88553098788624e-13 -1.01521651364956 0.000234705382361064 mirMAP -0.246405652657792 3.09182980578855e-05 NA NA NA hsa-miR-429 PRKCB 2.3794516574089 1.72813419703734e-13 -1.01521651364956 0.000234705382361064 MirTarget;miRanda;miRNATAP -0.166472060253132 6.28432741975052e-05 NA NA NA hsa-miR-450b-5p PRKCB 1.69248953402469 1.96052058003353e-07 -1.01521651364956 0.000234705382361064 miRNATAP -0.183354145967975 2.13964194654069e-05 NA NA NA hsa-miR-589-3p PRKCB 1.34253876396688 1.84935927493927e-05 -1.01521651364956 0.000234705382361064 mirMAP -0.153872579100374 0.000218865142512993 NA NA NA hsa-miR-589-5p PRKCB 0.233778899379261 0.228477190986199 -1.01521651364956 0.000234705382361064 mirMAP -0.191889757915074 0.00377217964937973 NA NA NA hsa-miR-590-5p PRKCB 2.07441240363458 4.95240551694843e-14 -1.01521651364956 0.000234705382361064 miRanda -0.247831270781318 8.78932489501914e-06 NA NA NA hsa-miR-7-1-3p PRKCB 2.61364240402652 1.98959237815786e-32 -1.01521651364956 0.000234705382361064 mirMAP -0.119995650641294 0.0359252672231447 NA NA NA hsa-miR-2110 PRKCG -1.92124860612475 1.1464887721828e-12 1.66883505426905 0.000268885102920086 MirTarget -0.307845409938279 6.49952836801256e-05 NA NA NA hsa-miR-326 PRKCG -0.992397386750901 0.00335173765975096 1.66883505426905 0.000268885102920086 miRanda -0.268960075781158 1.49724165244188e-05 NA NA NA hsa-miR-335-5p PRKCG -0.466533891325811 0.0676987038122831 1.66883505426905 0.000268885102920086 miRNAWalker2_validate -0.28334410784476 0.00233636911178136 NA NA NA hsa-miR-181a-5p PTPN11 -0.375429731222937 0.0562142867129802 -0.313926759091373 0.014358000979233 miRNAWalker2_validate;miRTarBase -0.205098363361928 3.55425058791527e-12 NA NA NA hsa-miR-186-5p PTPN11 0.852175445703945 6.88885738584309e-10 -0.313926759091373 0.014358000979233 mirMAP -0.166059774368664 8.74675396568392e-05 NA NA NA hsa-miR-28-5p PTPN11 1.19639196514745 4.59365801666536e-18 -0.313926759091373 0.014358000979233 miRanda -0.118441806126089 0.00448101443885386 NA NA NA hsa-miR-30d-3p PTPN11 0.00396376345349925 0.986457040013182 -0.313926759091373 0.014358000979233 mirMAP -0.119423879568279 2.4036932971846e-05 NA NA NA hsa-miR-30e-3p PTPN11 -0.104420043859122 0.526240453209293 -0.313926759091373 0.014358000979233 mirMAP -0.151019925354087 2.70098934287585e-05 NA NA NA hsa-miR-429 PTPN11 2.3794516574089 1.72813419703734e-13 -0.313926759091373 0.014358000979233 miRNATAP -0.105487532163286 3.01671898839701e-08 NA NA NA hsa-miR-455-5p PTPN11 1.36946341828134 5.05118627562807e-08 -0.313926759091373 0.014358000979233 miRanda -0.123759622736364 3.28445477193252e-06 NA NA NA hsa-miR-660-5p PTPN11 2.04875198906126 1.08269480928897e-17 -0.313926759091373 0.014358000979233 mirMAP -0.125682579233685 2.01541941486471e-07 NA NA NA hsa-miR-194-5p PTPN13 1.76979641760284 8.2064222072696e-05 -1.76992614272673 1.81831864879801e-06 miRNAWalker2_validate;miRTarBase -0.1271046927646 0.000828021703433189 NA NA NA hsa-miR-194-5p PTPRD 1.76979641760284 8.2064222072696e-05 -1.66030131903573 9.3195371074918e-08 miRNATAP -0.105675464658567 0.000948912378607666 NA NA NA hsa-miR-199a-5p RAB5A 1.3057193856884 2.38429382751645e-08 -0.120585153772645 0.19459181767715 miRanda -0.103682827848757 4.57660519676151e-09 NA NA NA hsa-miR-130a-3p RAB5B 0.881660100597014 0.000158893668519248 -0.358079794631734 0.000298900670964434 miRNATAP -0.103136847708888 8.33166755939616e-08 NA NA NA hsa-miR-454-3p RAB5B 1.49453641052169 4.46235742871434e-09 -0.358079794631734 0.000298900670964434 miRNATAP -0.102617011100738 9.35113090862986e-07 NA NA NA hsa-miR-93-5p RAB5B 1.50844106515467 1.83836866996875e-12 -0.358079794631734 0.000298900670964434 miRNAWalker2_validate;miRNATAP -0.127751569283927 4.68834234177621e-10 NA NA NA hsa-miR-30c-5p RAC1 -0.327319105755825 0.123595832152687 0.217355195910818 0.0528286499053578 miRNAWalker2_validate -0.11419324793125 2.23761362474291e-06 NA NA NA hsa-miR-193b-3p RAC2 1.10444771306846 0.000822888533401377 -0.656275624483639 0.00297441142612925 miRNAWalker2_validate -0.112838589622127 0.000231783502607722 NA NA NA hsa-miR-125a-5p RAC3 -1.04824536696301 3.97386082850476e-07 1.82835649257478 3.33704760151114e-09 PITA -0.183541043002533 0.00831332585841968 NA NA NA hsa-miR-30c-2-3p RAC3 -3.10905250533941 6.84550165664783e-27 1.82835649257478 3.33704760151114e-09 miRNAWalker2_validate -0.370936437115312 5.24524075378395e-16 NA NA NA hsa-miR-181a-5p RALA -0.375429731222937 0.0562142867129802 -0.261879655012526 0.0253893454936316 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.107150579646969 9.12635283441624e-05 26554155 The delivery of miR-181a specifically inhibited the growth of CML CD34+ cells possibly via the inhibition of RALA chronic myeloid leukemia hsa-miR-29c-3p RALA 1.32354490728858 1.84279305179762e-07 -0.261879655012526 0.0253893454936316 miRNATAP -0.102312717216111 8.43495127680163e-07 NA NA NA hsa-miR-30d-3p RALA 0.00396376345349925 0.986457040013182 -0.261879655012526 0.0253893454936316 MirTarget;miRNATAP -0.110418239840817 1.85793137291453e-05 NA NA NA hsa-miR-200b-3p RALB 1.55157578247391 4.83790020897188e-09 -0.358126731679962 0.0030128290440561 MirTarget -0.130347234795377 1.28367722635379e-10 NA NA NA hsa-miR-200c-3p RALB 0.380533388300368 0.0842181838538353 -0.358126731679962 0.0030128290440561 MirTarget -0.101185488706223 5.89023460439867e-05 NA NA NA hsa-miR-30d-3p RALB 0.00396376345349925 0.986457040013182 -0.358126731679962 0.0030128290440561 MirTarget -0.150731760748297 1.19231114139033e-08 NA NA NA hsa-miR-429 RALB 2.3794516574089 1.72813419703734e-13 -0.358126731679962 0.0030128290440561 MirTarget;miRanda -0.118110295923032 3.38683459416035e-11 NA NA NA hsa-miR-664a-5p RALB -0.0936480603578111 0.662274905077117 -0.358126731679962 0.0030128290440561 MirTarget -0.102993089436718 0.000112661268280795 NA NA NA hsa-miR-96-5p RALB 3.0381097138467 4.40362891630201e-24 -0.358126731679962 0.0030128290440561 TargetScan -0.120811173761079 1.53269977950985e-09 NA NA NA hsa-miR-125a-5p RALBP1 -1.04824536696301 3.97386082850476e-07 -0.071761463677773 0.563446550590947 miRNAWalker2_validate -0.111208997305709 4.31964449410278e-05 NA NA NA hsa-miR-148a-3p RALBP1 2.30885799126944 1.95226081368985e-21 -0.071761463677773 0.563446550590947 MirTarget;miRNATAP -0.118524156097606 9.21348069189768e-08 NA NA NA hsa-miR-16-2-3p RAP1A 0.503964803530872 0.0263648405197492 -0.603987305278772 9.11805459598191e-08 MirTarget;mirMAP -0.106891491539267 1.98650883323999e-05 NA NA NA hsa-miR-19a-3p RAP1A 2.11776595911517 7.07663078397156e-10 -0.603987305278772 9.11805459598191e-08 MirTarget;miRNATAP -0.157123037526092 8.30080921474088e-20 NA NA NA hsa-miR-19b-3p RAP1A 2.10868505662119 5.40846613768389e-17 -0.603987305278772 9.11805459598191e-08 MirTarget;miRNATAP -0.175406562788395 1.47000077647285e-17 NA NA NA hsa-miR-25-3p RAP1A 0.361927330834176 0.0163670566170988 -0.603987305278772 9.11805459598191e-08 mirMAP -0.115157280326491 0.00105562262009864 NA NA NA hsa-miR-324-5p RAP1A 1.06955541886548 5.39722006604758e-05 -0.603987305278772 9.11805459598191e-08 miRanda -0.154377217785499 7.03803242145569e-16 NA NA NA hsa-miR-335-3p RAP1A 1.51116383169018 6.88553098788624e-13 -0.603987305278772 9.11805459598191e-08 mirMAP -0.110111758660811 5.70175474136553e-06 NA NA NA hsa-miR-664a-3p RAP1A 0.443077463053857 0.0214248925850984 -0.603987305278772 9.11805459598191e-08 mirMAP -0.110687522710715 4.94872229467202e-05 NA NA NA hsa-miR-7-1-3p RAP1A 2.61364240402652 1.98959237815786e-32 -0.603987305278772 9.11805459598191e-08 mirMAP -0.128455351235968 3.0268199804302e-08 NA NA NA hsa-miR-92a-3p RAP1A -0.136362762339122 0.493412263619364 -0.603987305278772 9.11805459598191e-08 mirMAP;miRNATAP -0.14296374476131 5.16925020581449e-08 NA NA NA hsa-miR-181c-5p RAP1B 0.529875814537156 0.0125885822998008 -0.417268909306394 0.00207583774926411 MirTarget;miRNATAP -0.108062036854663 0.00023571671707159 NA NA NA hsa-miR-19a-3p RAP1B 2.11776595911517 7.07663078397156e-10 -0.417268909306394 0.00207583774926411 MirTarget;miRNATAP -0.13453800931744 1.36134874659401e-10 NA NA NA hsa-miR-19b-3p RAP1B 2.10868505662119 5.40846613768389e-17 -0.417268909306394 0.00207583774926411 MirTarget;miRNATAP -0.178926166950946 4.39964114081487e-13 NA NA NA hsa-miR-200b-3p RAP1B 1.55157578247391 4.83790020897188e-09 -0.417268909306394 0.00207583774926411 MirTarget;TargetScan -0.100968257550172 1.19178136736062e-05 NA NA NA hsa-miR-25-3p RAP1B 0.361927330834176 0.0163670566170988 -0.417268909306394 0.00207583774926411 MirTarget;miRNATAP -0.114384070887763 0.00628917356203576 NA NA NA hsa-miR-27b-3p RAP1B 0.236438984240408 0.12263510345883 -0.417268909306394 0.00207583774926411 MirTarget -0.124182010202537 0.00259619765230713 NA NA NA hsa-miR-30b-5p RAP1B 0.358144314839612 0.138026229059594 -0.417268909306394 0.00207583774926411 MirTarget -0.158691377313009 4.94355444608665e-10 NA NA NA hsa-miR-30c-5p RAP1B -0.327319105755825 0.123595832152687 -0.417268909306394 0.00207583774926411 MirTarget;miRNATAP -0.167435099209743 8.86891242793365e-09 NA NA NA hsa-miR-30d-5p RAP1B -0.920901858717441 3.50898334321668e-05 -0.417268909306394 0.00207583774926411 MirTarget;miRNATAP -0.123352169318874 8.8745038347385e-06 NA NA NA hsa-miR-92a-3p RAP1B -0.136362762339122 0.493412263619364 -0.417268909306394 0.00207583774926411 MirTarget;miRNATAP -0.117343559671965 0.00019224829545818 NA NA NA hsa-miR-92b-3p RAP1B 0.0478787637665503 0.831716894621477 -0.417268909306394 0.00207583774926411 MirTarget;miRNATAP -0.108575387170973 9.06328904550033e-05 NA NA NA hsa-miR-107 RAPGEF5 0.658676029898313 5.11480446318819e-07 -1.09215579245787 2.16207043530512e-07 miRanda -0.172391605286067 0.0221052434033994 NA NA NA hsa-miR-141-3p RAPGEF5 3.36993755486106 5.42939251147195e-32 -1.09215579245787 2.16207043530512e-07 MirTarget -0.111313012057009 0.000484987124299203 NA NA NA hsa-miR-17-5p RAPGEF5 2.07078488653279 2.77403038572568e-19 -1.09215579245787 2.16207043530512e-07 TargetScan -0.256002943331893 2.05192163375664e-10 NA NA NA hsa-miR-186-5p RAPGEF5 0.852175445703945 6.88885738584309e-10 -1.09215579245787 2.16207043530512e-07 mirMAP -0.203530766785128 0.00402356223885342 NA NA NA hsa-miR-193a-3p RAPGEF5 0.549173467360291 0.0319030569365466 -1.09215579245787 2.16207043530512e-07 miRanda -0.215007821170051 1.8621877418596e-07 NA NA NA hsa-miR-19a-3p RAPGEF5 2.11776595911517 7.07663078397156e-10 -1.09215579245787 2.16207043530512e-07 mirMAP -0.159804483311289 1.55421527716361e-06 NA NA NA hsa-miR-19b-3p RAPGEF5 2.10868505662119 5.40846613768389e-17 -1.09215579245787 2.16207043530512e-07 mirMAP -0.154014043787406 0.000101183754866216 NA NA NA hsa-miR-2355-5p RAPGEF5 1.86174980095465 3.47492783095613e-13 -1.09215579245787 2.16207043530512e-07 MirTarget -0.159898812430887 7.71741518127204e-05 NA NA NA hsa-miR-29a-5p RAPGEF5 1.89519956688438 1.03453349363915e-11 -1.09215579245787 2.16207043530512e-07 mirMAP -0.172984336389257 2.4933049557524e-05 NA NA NA hsa-miR-320b RAPGEF5 0.226640952564488 0.378818692487242 -1.09215579245787 2.16207043530512e-07 miRanda;mirMAP -0.120144706932724 0.00165342121588415 NA NA NA hsa-miR-331-5p RAPGEF5 0.578237334664505 0.00131211239210882 -1.09215579245787 2.16207043530512e-07 miRNATAP -0.121631370667339 0.030694623589844 NA NA NA hsa-miR-335-3p RAPGEF5 1.51116383169018 6.88553098788624e-13 -1.09215579245787 2.16207043530512e-07 mirMAP -0.105710976432522 0.0207727161160672 NA NA NA hsa-miR-421 RAPGEF5 0.170525317701774 0.535277026680289 -1.09215579245787 2.16207043530512e-07 miRanda -0.26084625069101 7.39090981255792e-12 NA NA NA hsa-miR-450b-5p RAPGEF5 1.69248953402469 1.96052058003353e-07 -1.09215579245787 2.16207043530512e-07 mirMAP -0.103665090955796 0.00184598361525884 NA NA NA hsa-miR-576-5p RAPGEF5 1.02693643167056 1.14846964470173e-06 -1.09215579245787 2.16207043530512e-07 MirTarget;PITA -0.34831197907617 8.9549331476128e-15 NA NA NA hsa-miR-590-3p RAPGEF5 0.83851360565783 0.00129224433453587 -1.09215579245787 2.16207043530512e-07 PITA;miRanda;mirMAP -0.308818141857912 2.62396486600387e-12 NA NA NA hsa-miR-629-3p RAPGEF5 1.31892116211001 0.000114487182853678 -1.09215579245787 2.16207043530512e-07 MirTarget -0.20107904103879 3.66959395969438e-11 NA NA NA hsa-miR-7-1-3p RAPGEF5 2.61364240402652 1.98959237815786e-32 -1.09215579245787 2.16207043530512e-07 mirMAP -0.208625726601511 1.62508202786458e-06 NA NA NA hsa-miR-130b-3p RASA1 1.83046548750752 5.04753914574694e-13 0.0830814913632443 0.570442868486062 MirTarget -0.125028016496831 3.93404024277248e-06 NA NA NA hsa-miR-132-3p RASA1 0.0122601212105202 0.934032846062939 0.0830814913632443 0.570442868486062 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.114943606316762 0.0125413661237337 NA NA NA hsa-miR-320b RASA1 0.226640952564488 0.378818692487242 0.0830814913632443 0.570442868486062 MirTarget;PITA;miRanda;miRNATAP -0.115959001937082 8.13385461561195e-06 NA NA NA hsa-miR-330-5p RASA1 0.168520831101569 0.336433937906706 0.0830814913632443 0.570442868486062 miRanda -0.111577183760699 0.00389299758466792 NA NA NA hsa-miR-421 RASA1 0.170525317701774 0.535277026680289 0.0830814913632443 0.570442868486062 MirTarget;PITA;miRanda;miRNATAP -0.127023094202489 1.48010705227606e-06 NA NA NA hsa-miR-454-3p RASA1 1.49453641052169 4.46235742871434e-09 0.0830814913632443 0.570442868486062 MirTarget -0.124196414032519 6.07092903847995e-05 NA NA NA hsa-miR-590-3p RASA1 0.83851360565783 0.00129224433453587 0.0830814913632443 0.570442868486062 miRanda -0.159770357317914 1.69631651700077e-07 NA NA NA hsa-miR-590-5p RASA1 2.07441240363458 4.95240551694843e-14 0.0830814913632443 0.570442868486062 miRNATAP -0.148865940378909 3.4625557396617e-07 NA NA NA hsa-miR-141-3p RASA2 3.36993755486106 5.42939251147195e-32 -0.122908970487031 0.513876717364579 TargetScan -0.124746567469002 8.33312500699408e-06 NA NA NA hsa-miR-30b-5p RASA2 0.358144314839612 0.138026229059594 -0.122908970487031 0.513876717364579 mirMAP -0.162230314445943 5.4166425604864e-06 NA NA NA hsa-miR-30c-5p RASA2 -0.327319105755825 0.123595832152687 -0.122908970487031 0.513876717364579 mirMAP -0.104934352392031 0.0102923322657111 NA NA NA hsa-miR-335-5p RASA2 -0.466533891325811 0.0676987038122831 -0.122908970487031 0.513876717364579 miRNAWalker2_validate -0.123917328048337 0.00108261070271957 NA NA NA hsa-miR-664a-3p RASA2 0.443077463053857 0.0214248925850984 -0.122908970487031 0.513876717364579 mirMAP -0.178593261369568 7.01250096406581e-05 NA NA NA hsa-miR-186-5p RASA3 0.852175445703945 6.88885738584309e-10 -0.653683726177163 0.00136063390240146 miRNATAP -0.139680329055362 0.0402525542047789 NA NA NA hsa-miR-335-5p RASA3 -0.466533891325811 0.0676987038122831 -0.653683726177163 0.00136063390240146 miRNAWalker2_validate -0.120488481551872 0.00359314638876445 NA NA NA hsa-miR-3913-5p RASA4 0.717213610841846 0.00237248441853322 -0.468969476684961 0.0181791598505331 mirMAP -0.123038762148839 0.0107525408131521 NA NA NA hsa-miR-107 RASAL2 0.658676029898313 5.11480446318819e-07 -0.753342580172097 1.93006196736568e-06 miRanda -0.220228359271551 8.6329017148708e-05 NA NA NA hsa-miR-135b-5p RASAL2 3.25019233805845 1.95560099639034e-15 -0.753342580172097 1.93006196736568e-06 MirTarget -0.106965718471534 8.89927774146231e-09 NA NA NA hsa-miR-141-3p RASAL2 3.36993755486106 5.42939251147195e-32 -0.753342580172097 1.93006196736568e-06 mirMAP -0.178090530877134 2.17399917011797e-14 NA NA NA hsa-miR-148a-5p RASAL2 1.45633512586855 1.81792463521257e-08 -0.753342580172097 1.93006196736568e-06 mirMAP -0.180269433070199 5.58691454256512e-11 NA NA NA hsa-miR-181c-5p RASAL2 0.529875814537156 0.0125885822998008 -0.753342580172097 1.93006196736568e-06 mirMAP -0.17893173132152 1.88374757550377e-07 NA NA NA hsa-miR-186-5p RASAL2 0.852175445703945 6.88885738584309e-10 -0.753342580172097 1.93006196736568e-06 mirMAP -0.275379966196933 1.50827090737589e-07 NA NA NA hsa-miR-200a-3p RASAL2 3.14766878548496 1.32850889777422e-21 -0.753342580172097 1.93006196736568e-06 mirMAP -0.171935737443586 4.63006399441823e-16 NA NA NA hsa-miR-200b-3p RASAL2 1.55157578247391 4.83790020897188e-09 -0.753342580172097 1.93006196736568e-06 mirMAP -0.175390626255582 5.99627073204364e-11 NA NA NA hsa-miR-200c-3p RASAL2 0.380533388300368 0.0842181838538353 -0.753342580172097 1.93006196736568e-06 mirMAP -0.221350530678405 1.51398299924818e-11 NA NA NA hsa-miR-20a-3p RASAL2 2.51803599558247 4.92479325298629e-13 -0.753342580172097 1.93006196736568e-06 mirMAP -0.119937797681181 5.53818441872653e-06 NA NA NA hsa-miR-26b-3p RASAL2 1.37388760789373 8.32526977075803e-09 -0.753342580172097 1.93006196736568e-06 MirTarget -0.165554032173471 3.59278381914081e-08 NA NA NA hsa-miR-26b-5p RASAL2 0.72362441215247 4.7794659748036e-05 -0.753342580172097 1.93006196736568e-06 miRNAWalker2_validate -0.210968747432265 2.49415883317681e-07 NA NA NA hsa-miR-29b-3p RASAL2 3.10527711861309 3.01242507282711e-32 -0.753342580172097 1.93006196736568e-06 MirTarget -0.110838621786137 1.94605830161869e-05 NA NA NA hsa-miR-29c-3p RASAL2 1.32354490728858 1.84279305179762e-07 -0.753342580172097 1.93006196736568e-06 MirTarget -0.123346267901676 1.47673322479827e-05 NA NA NA hsa-miR-30d-3p RASAL2 0.00396376345349925 0.986457040013182 -0.753342580172097 1.93006196736568e-06 mirMAP -0.129201773504054 0.00025606025842362 NA NA NA hsa-miR-429 RASAL2 2.3794516574089 1.72813419703734e-13 -0.753342580172097 1.93006196736568e-06 mirMAP -0.15731117466586 2.4653172174797e-11 NA NA NA hsa-miR-664a-3p RASAL2 0.443077463053857 0.0214248925850984 -0.753342580172097 1.93006196736568e-06 mirMAP -0.149012574800091 9.53458740420765e-05 NA NA NA hsa-miR-92a-3p RASAL2 -0.136362762339122 0.493412263619364 -0.753342580172097 1.93006196736568e-06 miRNAWalker2_validate -0.113743345864253 0.00218888566005131 NA NA NA hsa-miR-127-5p RASGRF1 2.05164948368907 3.61318574536718e-09 -3.70733405775563 1.10306468296224e-12 MirTarget -0.203114377416237 0.00348610022536499 NA NA NA hsa-miR-320b RASGRF1 0.226640952564488 0.378818692487242 -3.70733405775563 1.10306468296224e-12 miRanda -0.256365411096161 0.00749810890372983 NA NA NA hsa-miR-331-5p RASGRF1 0.578237334664505 0.00131211239210882 -3.70733405775563 1.10306468296224e-12 miRNATAP -0.392217378465777 0.00536866354811249 NA NA NA hsa-miR-3913-5p RASGRF1 0.717213610841846 0.00237248441853322 -3.70733405775563 1.10306468296224e-12 mirMAP -0.281444551419807 0.0302866576934511 NA NA NA hsa-miR-454-3p RASGRF1 1.49453641052169 4.46235742871434e-09 -3.70733405775563 1.10306468296224e-12 mirMAP -0.371087102816134 0.00111169312696212 NA NA NA hsa-miR-675-3p RASGRF1 0.319853014141687 0.608023216370348 -3.70733405775563 1.10306468296224e-12 MirTarget -0.155760735845356 0.000129683343299328 NA NA NA hsa-miR-708-3p RASGRF1 3.43841959417743 4.40027692981683e-28 -3.70733405775563 1.10306468296224e-12 mirMAP -0.495369446215287 1.18199246105259e-09 NA NA NA hsa-miR-106a-5p RASGRF2 1.3902608059488 6.07931522284525e-05 -0.287352893796794 0.257335594453799 MirTarget -0.144051926956735 0.000108587452832706 NA NA NA hsa-miR-106b-5p RASGRF2 1.47447672652218 1.32004094930462e-13 -0.287352893796794 0.257335594453799 MirTarget -0.285206361233893 5.05993782578971e-07 NA NA NA hsa-miR-1266-5p RASGRF2 -0.289721391624349 0.281500764553995 -0.287352893796794 0.257335594453799 MirTarget -0.19033934438021 1.05285663067015e-05 NA NA NA hsa-miR-17-5p RASGRF2 2.07078488653279 2.77403038572568e-19 -0.287352893796794 0.257335594453799 MirTarget;TargetScan -0.261351718418575 5.66980196022638e-08 NA NA NA hsa-miR-182-5p RASGRF2 3.21839823004635 5.13049145201115e-39 -0.287352893796794 0.257335594453799 mirMAP -0.158375356189279 0.000262464376525276 NA NA NA hsa-miR-20a-5p RASGRF2 2.64649625616975 5.1469418982085e-27 -0.287352893796794 0.257335594453799 MirTarget -0.217638242084763 9.73169257314874e-07 NA NA NA hsa-miR-3065-5p RASGRF2 0.653308707552535 0.0999497219778851 -0.287352893796794 0.257335594453799 mirMAP -0.117859340340122 0.000214759070927914 NA NA NA hsa-miR-30d-3p RASGRF2 0.00396376345349925 0.986457040013182 -0.287352893796794 0.257335594453799 mirMAP -0.227429688703671 4.89152043056184e-05 NA NA NA hsa-miR-324-5p RASGRF2 1.06955541886548 5.39722006604758e-05 -0.287352893796794 0.257335594453799 miRNATAP -0.177991731039237 4.44152156318357e-05 NA NA NA hsa-miR-3614-5p RASGRF2 -1.19394699210224 2.53933783780868e-05 -0.287352893796794 0.257335594453799 MirTarget -0.111065218214539 0.00670194283927968 NA NA NA hsa-miR-421 RASGRF2 0.170525317701774 0.535277026680289 -0.287352893796794 0.257335594453799 miRanda;mirMAP -0.160002931287835 0.000519961515110835 NA NA NA hsa-miR-429 RASGRF2 2.3794516574089 1.72813419703734e-13 -0.287352893796794 0.257335594453799 miRanda -0.179178495421922 2.20550434430322e-06 NA NA NA hsa-miR-590-3p RASGRF2 0.83851360565783 0.00129224433453587 -0.287352893796794 0.257335594453799 MirTarget;miRanda -0.136956114027793 0.01069838383387 NA NA NA hsa-miR-590-5p RASGRF2 2.07441240363458 4.95240551694843e-14 -0.287352893796794 0.257335594453799 miRanda -0.161156050929219 0.00163754848848733 NA NA NA hsa-miR-664a-3p RASGRF2 0.443077463053857 0.0214248925850984 -0.287352893796794 0.257335594453799 mirMAP -0.130955651729668 0.0317168016224394 NA NA NA hsa-miR-93-5p RASGRF2 1.50844106515467 1.83836866996875e-12 -0.287352893796794 0.257335594453799 MirTarget -0.301711451461713 1.02031758886157e-08 NA NA NA hsa-miR-148b-3p RASGRP1 0.483970528590224 0.0026495409465901 0.22596138326471 0.410804336760924 MirTarget -0.312744556962803 7.01733576317429e-05 NA NA NA hsa-miR-17-3p RASGRP1 1.36706429551147 4.60388403547821e-13 0.22596138326471 0.410804336760924 MirTarget -0.171494116861819 0.00892405874048536 NA NA NA hsa-miR-2355-3p RASGRP1 1.10676344164715 6.24068383465151e-06 0.22596138326471 0.410804336760924 MirTarget -0.226445417036981 2.55407091052512e-05 NA NA NA hsa-miR-320b RASGRP1 0.226640952564488 0.378818692487242 0.22596138326471 0.410804336760924 miRanda -0.18084750476964 0.000226735231862998 NA NA NA hsa-miR-331-5p RASGRP1 0.578237334664505 0.00131211239210882 0.22596138326471 0.410804336760924 PITA;miRNATAP -0.226695457613606 0.00169965895293423 NA NA NA hsa-miR-335-5p RASGRP1 -0.466533891325811 0.0676987038122831 0.22596138326471 0.410804336760924 miRNAWalker2_validate -0.20840084575315 0.000163607256537204 NA NA NA hsa-miR-582-5p RASGRP1 1.08286181406653 0.00149040450161757 0.22596138326471 0.410804336760924 MirTarget -0.105781090882875 0.00520880833224736 NA NA NA hsa-miR-590-3p RASGRP1 0.83851360565783 0.00129224433453587 0.22596138326471 0.410804336760924 PITA;miRanda;mirMAP -0.124527779500543 0.0322621737581239 NA NA NA hsa-miR-590-5p RASGRP1 2.07441240363458 4.95240551694843e-14 0.22596138326471 0.410804336760924 MirTarget;PITA;miRanda;miRNATAP -0.228220127040697 3.55733291464349e-05 NA NA NA hsa-miR-28-5p RASGRP2 1.19639196514745 4.59365801666536e-18 -1.70792894200752 7.20369044586562e-08 miRNATAP -0.348829561390059 0.000844065552095291 NA NA NA hsa-miR-324-3p RASGRP2 -0.0774700133118458 0.689226297032231 -1.70792894200752 7.20369044586562e-08 PITA -0.191896996479218 0.0127688619008863 NA NA NA hsa-miR-940 RASGRP2 0.011138136211269 0.974925352379525 -1.70792894200752 7.20369044586562e-08 MirTarget;PITA;miRNATAP -0.124206075895981 0.00824270080689898 NA NA NA hsa-miR-324-3p RASGRP3 -0.0774700133118458 0.689226297032231 -0.262127468715428 0.124284914851264 MirTarget -0.147946379885594 0.000272445945719952 NA NA NA hsa-miR-590-5p RASGRP3 2.07441240363458 4.95240551694843e-14 -0.262127468715428 0.124284914851264 miRanda -0.109122755261431 0.00150156761622915 NA NA NA hsa-miR-28-5p RASGRP4 1.19639196514745 4.59365801666536e-18 -2.53021554805935 2.73320608789663e-19 miRanda -0.410286265509764 1.57380700977574e-05 NA NA NA hsa-miR-542-3p RASGRP4 1.62226640768239 2.6427102465476e-10 -2.53021554805935 2.73320608789663e-19 miRanda -0.173477338007722 0.000776399032176071 NA NA NA hsa-miR-625-5p RASGRP4 1.38208523187596 6.28473801440755e-07 -2.53021554805935 2.73320608789663e-19 MirTarget -0.146975162377984 0.00645598627434084 NA NA NA hsa-miR-744-5p RASSF1 -0.490424133130113 0.00934825173175428 -0.492735624139588 2.32227085230114e-05 miRNAWalker2_validate -0.103347494370685 0.000297535888238654 NA NA NA hsa-miR-107 RASSF5 0.658676029898313 5.11480446318819e-07 -0.762232040461735 2.73165460783976e-05 PITA;miRanda;miRNATAP -0.205115530530201 0.00146230907609879 NA NA NA hsa-miR-193b-3p RASSF5 1.10444771306846 0.000822888533401377 -0.762232040461735 2.73165460783976e-05 miRNAWalker2_validate -0.177636947666694 8.04618692951266e-13 NA NA NA hsa-miR-421 RASSF5 0.170525317701774 0.535277026680289 -0.762232040461735 2.73165460783976e-05 miRanda -0.197880111866508 1.71562978032893e-09 NA NA NA hsa-miR-576-5p RASSF5 1.02693643167056 1.14846964470173e-06 -0.762232040461735 2.73165460783976e-05 mirMAP -0.210386650238439 7.91487739132611e-08 NA NA NA hsa-miR-9-5p RASSF5 4.99250901331516 2.59132733422801e-19 -0.762232040461735 2.73165460783976e-05 mirMAP -0.102233004642707 5.64531687511828e-13 NA NA NA hsa-miR-16-1-3p REL 1.50034693398929 6.63958242991125e-10 -0.344611970314376 0.133103833914491 MirTarget -0.125596268393959 0.0182781573073286 NA NA NA hsa-miR-106a-5p RGL1 1.3902608059488 6.07931522284525e-05 -0.967560396454387 3.40988806539769e-06 MirTarget;miRNATAP -0.15082449598974 9.20007396468999e-07 NA NA NA hsa-miR-106b-5p RGL1 1.47447672652218 1.32004094930462e-13 -0.967560396454387 3.40988806539769e-06 MirTarget;miRNATAP -0.266168017832897 1.41318476600026e-08 NA NA NA hsa-miR-16-2-3p RGL1 0.503964803530872 0.0263648405197492 -0.967560396454387 3.40988806539769e-06 mirMAP -0.172617901285338 0.00019140142834324 NA NA NA hsa-miR-17-5p RGL1 2.07078488653279 2.77403038572568e-19 -0.967560396454387 3.40988806539769e-06 MirTarget;TargetScan;miRNATAP -0.275249430908781 3.38901285966874e-12 NA NA NA hsa-miR-182-5p RGL1 3.21839823004635 5.13049145201115e-39 -0.967560396454387 3.40988806539769e-06 MirTarget -0.102217142368485 0.0046395675993242 NA NA NA hsa-miR-193a-3p RGL1 0.549173467360291 0.0319030569365466 -0.967560396454387 3.40988806539769e-06 miRNATAP -0.138054103269624 0.000764493394313614 NA NA NA hsa-miR-19a-3p RGL1 2.11776595911517 7.07663078397156e-10 -0.967560396454387 3.40988806539769e-06 MirTarget;miRNATAP -0.211218671950195 7.78568751273021e-11 NA NA NA hsa-miR-19b-3p RGL1 2.10868505662119 5.40846613768389e-17 -0.967560396454387 3.40988806539769e-06 MirTarget;miRNATAP -0.207469076833676 8.8579412088464e-08 NA NA NA hsa-miR-200c-3p RGL1 0.380533388300368 0.0842181838538353 -0.967560396454387 3.40988806539769e-06 MirTarget;miRNATAP -0.220789346541378 4.29600618209418e-07 NA NA NA hsa-miR-20a-5p RGL1 2.64649625616975 5.1469418982085e-27 -0.967560396454387 3.40988806539769e-06 MirTarget;miRNATAP -0.236419619831429 9.63865235119372e-11 NA NA NA hsa-miR-22-5p RGL1 1.71436244278242 9.85038001236064e-15 -0.967560396454387 3.40988806539769e-06 mirMAP -0.226256686207134 7.6371094787583e-08 NA NA NA hsa-miR-25-3p RGL1 0.361927330834176 0.0163670566170988 -0.967560396454387 3.40988806539769e-06 MirTarget -0.129833215346223 0.0458717069024148 NA NA NA hsa-miR-32-5p RGL1 0.876853679269853 6.04859399018691e-05 -0.967560396454387 3.40988806539769e-06 MirTarget -0.135758054438187 0.00461882954634149 NA NA NA hsa-miR-335-3p RGL1 1.51116383169018 6.88553098788624e-13 -0.967560396454387 3.40988806539769e-06 mirMAP -0.177245661350874 7.7294401005483e-05 NA NA NA hsa-miR-582-3p RGL1 1.70881364237226 1.26508456000083e-06 -0.967560396454387 3.40988806539769e-06 PITA -0.192762893841274 3.41361052993526e-13 NA NA NA hsa-miR-7-1-3p RGL1 2.61364240402652 1.98959237815786e-32 -0.967560396454387 3.40988806539769e-06 MirTarget;mirMAP -0.233038824804948 5.01453407622692e-08 NA NA NA hsa-miR-708-5p RGL1 3.04047795672813 3.01085192850869e-20 -0.967560396454387 3.40988806539769e-06 MirTarget -0.124517082272589 6.94556144883513e-05 NA NA NA hsa-miR-92a-3p RGL1 -0.136362762339122 0.493412263619364 -0.967560396454387 3.40988806539769e-06 MirTarget -0.181563420751903 0.000198232339598067 NA NA NA hsa-miR-93-5p RGL1 1.50844106515467 1.83836866996875e-12 -0.967560396454387 3.40988806539769e-06 MirTarget;miRNATAP -0.270018034924882 5.79166039177601e-10 NA NA NA hsa-miR-96-5p RGL1 3.0381097138467 4.40362891630201e-24 -0.967560396454387 3.40988806539769e-06 mirMAP -0.171302427037816 1.04770472074544e-06 NA NA NA hsa-miR-24-3p RGL2 -0.0357874587555003 0.785865078836504 0.236540527995028 0.111375173163893 miRNATAP -0.21154205910398 5.68452139635867e-05 NA NA NA hsa-miR-27a-3p RGL2 0.433402568013802 0.00737164631768323 0.236540527995028 0.111375173163893 miRNATAP -0.137756490513785 0.001176799604719 NA NA NA hsa-miR-185-5p RHOA 1.14291034858482 2.95777119743491e-13 -0.611454267658683 6.71671176904016e-11 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.118476198992249 1.45868845487647e-05 NA NA NA hsa-miR-7-1-3p RHOA 2.61364240402652 1.98959237815786e-32 -0.611454267658683 6.71671176904016e-11 mirMAP -0.112127671880069 6.10082154871722e-09 NA NA NA hsa-miR-361-5p RIN1 0.21454431962475 0.0800957579368424 0.321692735244324 0.232708194670026 miRanda -0.212126551215416 0.040272315046427 NA NA NA hsa-miR-1306-3p RRAS 0.128239923662981 0.640502577294429 -1.34967041610552 2.3564515138194e-13 MirTarget -0.127414966107971 0.000110941454747152 NA NA NA hsa-miR-29b-3p RRAS2 3.10527711861309 3.01242507282711e-32 -0.384314789055802 0.0136066111874471 miRNATAP -0.142834477685943 1.31210929655112e-08 NA NA NA hsa-miR-93-5p RRAS2 1.50844106515467 1.83836866996875e-12 -0.384314789055802 0.0136066111874471 miRNAWalker2_validate -0.100240590212887 0.00222620247352813 NA NA NA hsa-miR-194-5p SAMD4A 1.76979641760284 8.2064222072696e-05 -1.27089348106065 2.91371609129609e-07 miRNATAP -0.176942793027697 1.22086989586392e-12 NA NA NA hsa-miR-194-5p SEMA5A 1.76979641760284 8.2064222072696e-05 -2.93236171912431 7.07249268215627e-21 mirMAP -0.148488182741033 6.8914038881713e-06 NA NA NA hsa-let-7g-3p SHC3 2.38336858943031 4.8771148585792e-17 -1.85339309262852 3.63639603200324e-06 MirTarget;miRNATAP -0.264028876657496 2.74863492827133e-05 NA NA NA hsa-miR-21-3p SHC3 2.54206008030157 1.11598785398763e-30 -1.85339309262852 3.63639603200324e-06 MirTarget -0.211535585661672 0.00749587174167999 NA NA NA hsa-miR-331-5p SHC3 0.578237334664505 0.00131211239210882 -1.85339309262852 3.63639603200324e-06 PITA;miRNATAP -0.323046538736812 0.00241473420910986 NA NA NA hsa-miR-590-5p SHC3 2.07441240363458 4.95240551694843e-14 -1.85339309262852 3.63639603200324e-06 miRanda -0.427314786421125 1.26517705416853e-07 NA NA NA hsa-miR-92a-3p SHC3 -0.136362762339122 0.493412263619364 -1.85339309262852 3.63639603200324e-06 miRNAWalker2_validate -0.238593451326016 0.0113129587146932 NA NA NA hsa-miR-16-1-3p SHC4 1.50034693398929 6.63958242991125e-10 -0.732055303942039 0.0131945868707011 MirTarget -0.206412116508825 0.00260689732026867 NA NA NA hsa-miR-182-5p SHC4 3.21839823004635 5.13049145201115e-39 -0.732055303942039 0.0131945868707011 MirTarget;miRNATAP -0.170604905933307 0.000769455672471723 NA NA NA hsa-miR-186-5p SHC4 0.852175445703945 6.88885738584309e-10 -0.732055303942039 0.0131945868707011 MirTarget;mirMAP -0.449918862089197 3.96290450905499e-06 NA NA NA hsa-miR-20a-3p SHC4 2.51803599558247 4.92479325298629e-13 -0.732055303942039 0.0131945868707011 miRNATAP -0.165588190633082 0.000759376044215313 NA NA NA hsa-miR-335-3p SHC4 1.51116383169018 6.88553098788624e-13 -0.732055303942039 0.0131945868707011 mirMAP -0.3008454756728 1.70291926819949e-06 NA NA NA hsa-miR-335-5p SHC4 -0.466533891325811 0.0676987038122831 -0.732055303942039 0.0131945868707011 miRNAWalker2_validate -0.135947706188996 0.0232537232263829 NA NA NA hsa-miR-576-5p SHC4 1.02693643167056 1.14846964470173e-06 -0.732055303942039 0.0131945868707011 mirMAP -0.287056822451243 6.53339941736284e-06 NA NA NA hsa-miR-590-3p SHC4 0.83851360565783 0.00129224433453587 -0.732055303942039 0.0131945868707011 PITA;miRanda;mirMAP;miRNATAP -0.158175166503193 0.0115881762028296 NA NA NA hsa-miR-628-5p SHC4 1.06173574237323 4.67541261016756e-06 -0.732055303942039 0.0131945868707011 MirTarget -0.151092304057696 0.0310335074363417 NA NA NA hsa-miR-96-5p SHC4 3.0381097138467 4.40362891630201e-24 -0.732055303942039 0.0131945868707011 TargetScan;miRNATAP -0.153358775717055 0.00205361235315158 NA NA NA hsa-miR-103a-3p SHOC2 0.538497806383155 1.88134691850591e-05 -0.264591625101072 0.011566415426951 miRNAWalker2_validate -0.203516783403965 9.88029846588698e-08 NA NA NA hsa-miR-15a-5p SHOC2 1.62575353599172 1.55312121019827e-19 -0.264591625101072 0.011566415426951 MirTarget;miRNATAP -0.165163313112999 7.38812281278211e-11 NA NA NA hsa-miR-17-5p SHOC2 2.07078488653279 2.77403038572568e-19 -0.264591625101072 0.011566415426951 MirTarget;TargetScan;miRNATAP -0.12351981827219 3.89233864828152e-10 NA NA NA hsa-miR-186-5p SHOC2 0.852175445703945 6.88885738584309e-10 -0.264591625101072 0.011566415426951 miRNATAP -0.189190802860654 3.32260054224904e-08 NA NA NA hsa-miR-199a-5p SHOC2 1.3057193856884 2.38429382751645e-08 -0.264591625101072 0.011566415426951 miRanda -0.123908145876555 5.55390662267814e-10 NA NA NA hsa-miR-199b-5p SHOC2 2.13822205171062 4.56262988762436e-15 -0.264591625101072 0.011566415426951 miRanda -0.105769884301468 3.23878042349901e-10 NA NA NA hsa-miR-20a-5p SHOC2 2.64649625616975 5.1469418982085e-27 -0.264591625101072 0.011566415426951 MirTarget;miRNATAP -0.11471848639735 2.67128717773351e-10 NA NA NA hsa-miR-30c-5p SHOC2 -0.327319105755825 0.123595832152687 -0.264591625101072 0.011566415426951 MirTarget;miRNATAP -0.165234986260762 8.76485829962505e-14 NA NA NA hsa-miR-34a-5p SHOC2 1.40588612517769 8.60097477768592e-12 -0.264591625101072 0.011566415426951 miRNATAP -0.163858243702079 2.41443863310319e-13 NA NA NA hsa-miR-361-5p SHOC2 0.21454431962475 0.0800957579368424 -0.264591625101072 0.011566415426951 PITA;miRanda -0.101208628195913 0.0115197615881771 NA NA NA hsa-miR-455-5p SHOC2 1.36946341828134 5.05118627562807e-08 -0.264591625101072 0.011566415426951 PITA;miRanda;miRNATAP -0.11339253660961 1.5897651279998e-07 NA NA NA hsa-miR-500a-5p SHOC2 0.648155655714409 0.0104657432932038 -0.264591625101072 0.011566415426951 MirTarget -0.121608047908248 2.28359229959708e-10 NA NA NA hsa-miR-93-5p SHOC2 1.50844106515467 1.83836866996875e-12 -0.264591625101072 0.011566415426951 MirTarget;miRNATAP -0.180076646754797 2.53027116948264e-17 NA NA NA hsa-miR-194-5p SLC16A9 1.76979641760284 8.2064222072696e-05 1.82612525464853 0.000949900261292062 miRNAWalker2_validate -0.334208559019875 1.79706227355659e-09 NA NA NA hsa-miR-194-5p SLC5A3 1.76979641760284 8.2064222072696e-05 0.908460348379878 1.7896106467656e-05 mirMAP -0.110797492638501 2.43650483141296e-07 NA NA NA hsa-miR-181a-5p SOS1 -0.375429731222937 0.0562142867129802 0.0798852744327974 0.432914353979627 MirTarget;miRNATAP -0.10469236503224 9.69385315635354e-06 NA NA NA hsa-miR-26a-2-3p SOS1 0.264287787772609 0.305653616292982 0.0798852744327974 0.432914353979627 mirMAP -0.11755820325968 1.45592951814447e-07 NA NA NA hsa-miR-30b-5p SOS1 0.358144314839612 0.138026229059594 0.0798852744327974 0.432914353979627 mirMAP -0.100738601906088 1.42009312360891e-07 NA NA NA hsa-miR-30c-5p SOS1 -0.327319105755825 0.123595832152687 0.0798852744327974 0.432914353979627 mirMAP;miRNATAP -0.118113245139624 5.71228815703205e-08 NA NA NA hsa-miR-664a-3p SOS1 0.443077463053857 0.0214248925850984 0.0798852744327974 0.432914353979627 mirMAP -0.10862184907092 6.79471781102034e-06 NA NA NA hsa-miR-30b-5p STK4 0.358144314839612 0.138026229059594 -0.370768525362291 0.00084097936697174 mirMAP -0.109036662468909 2.12140432446357e-07 NA NA NA hsa-miR-664a-3p STK4 0.443077463053857 0.0214248925850984 -0.370768525362291 0.00084097936697174 mirMAP -0.122729592974758 3.54828377283425e-06 NA NA NA hsa-miR-29a-3p SYNGAP1 0.101650412194573 0.573201097011668 -0.385693007387035 0.0142829278589837 miRNATAP -0.12232808479507 0.00251419907365232 NA NA NA hsa-miR-450a-5p TCF21 1.94284269183615 1.52883075909271e-07 -3.83674457795257 2.07869688173266e-22 MirTarget -0.277210405185441 4.2207194360617e-06 NA NA NA hsa-miR-199b-5p TEK 2.13822205171062 4.56262988762436e-15 -3.51849633344745 1.22859479372185e-33 miRanda -0.124204007028612 0.0157435890964123 NA NA NA hsa-miR-421 TEK 0.170525317701774 0.535277026680289 -3.51849633344745 1.22859479372185e-33 miRanda -0.235384971977901 3.52531182065665e-05 NA NA NA hsa-miR-129-5p TGFA -0.405735314747643 0.341485636033577 0.716092021233232 0.0361502264702024 miRanda;mirMAP -0.121124296234011 0.00108133059542916 NA NA NA hsa-miR-326 TGFA -0.992397386750901 0.00335173765975096 0.716092021233232 0.0361502264702024 miRanda -0.194754872845494 2.44496930317185e-05 NA NA NA hsa-miR-330-5p TGFA 0.168520831101569 0.336433937906706 0.716092021233232 0.0361502264702024 miRanda -0.444525202951942 7.55981323762078e-07 NA NA NA hsa-miR-33a-5p TGFA 2.80127809675219 5.09053890529424e-12 0.716092021233232 0.0361502264702024 mirMAP -0.118450625036473 0.011775742023262 NA NA NA hsa-miR-590-5p TGFA 2.07441240363458 4.95240551694843e-14 0.716092021233232 0.0361502264702024 mirMAP -0.160467961840495 0.0205067874990697 NA NA NA hsa-miR-92a-3p TGFA -0.136362762339122 0.493412263619364 0.716092021233232 0.0361502264702024 miRNAWalker2_validate -0.363824944890668 4.2136374441386e-06 NA NA NA hsa-miR-106b-5p TIAM1 1.47447672652218 1.32004094930462e-13 -1.15161178404697 1.76180407652893e-05 MirTarget;miRNATAP -0.197506948188074 0.00121855903954321 NA NA NA hsa-miR-1266-5p TIAM1 -0.289721391624349 0.281500764553995 -1.15161178404697 1.76180407652893e-05 MirTarget -0.146653047424825 0.00155042406474754 NA NA NA hsa-miR-141-3p TIAM1 3.36993755486106 5.42939251147195e-32 -1.15161178404697 1.76180407652893e-05 MirTarget;TargetScan;miRNATAP -0.329850496753261 4.23904698721115e-17 NA NA NA hsa-miR-17-5p TIAM1 2.07078488653279 2.77403038572568e-19 -1.15161178404697 1.76180407652893e-05 MirTarget;TargetScan;miRNATAP -0.220873513532373 1.92336091230129e-05 NA NA NA hsa-miR-183-5p TIAM1 2.39247234736657 3.92444525331999e-21 -1.15161178404697 1.76180407652893e-05 miRNATAP -0.237945765387038 3.2187427342309e-07 NA NA NA hsa-miR-200a-3p TIAM1 3.14766878548496 1.32850889777422e-21 -1.15161178404697 1.76180407652893e-05 MirTarget;miRNATAP -0.190461495114478 1.97104859969564e-07 NA NA NA hsa-miR-20a-5p TIAM1 2.64649625616975 5.1469418982085e-27 -1.15161178404697 1.76180407652893e-05 MirTarget;miRNATAP -0.199834547905938 2.68073074847323e-05 NA NA NA hsa-miR-21-5p TIAM1 4.38165933891779 1.52536633902505e-92 -1.15161178404697 1.76180407652893e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.177500253479744 0.000173004493622405 20826792 miR 21 and miR 31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells; We present compelling evidence that TIAM1 a guanidine exchange factor of the Rac GTPase is a direct target of both miR-21 and miR-31 colon cancer hsa-miR-29b-3p TIAM1 3.10527711861309 3.01242507282711e-32 -1.15161178404697 1.76180407652893e-05 miRNATAP -0.165136573701705 0.000178592128570845 25032858 miR 29b suppresses tumor growth and metastasis in colorectal cancer via downregulating Tiam1 expression and inhibiting epithelial mesenchymal transition; Further studies found that T lymphoma invasion and metastasis 1 Tiam1 was identified as a direct target of miR-29b metastasis colorectal cancer hsa-miR-335-3p TIAM1 1.51116383169018 6.88553098788624e-13 -1.15161178404697 1.76180407652893e-05 MirTarget -0.164830638933664 0.00442298982899462 NA NA NA hsa-miR-338-3p TIAM1 0.726843067232002 0.0506251324215494 -1.15161178404697 1.76180407652893e-05 miRanda -0.106396492608495 0.00144159462212495 NA NA NA hsa-miR-93-5p TIAM1 1.50844106515467 1.83836866996875e-12 -1.15161178404697 1.76180407652893e-05 MirTarget;miRNATAP -0.123124394565136 0.0309687615910398 NA NA NA hsa-miR-96-5p TIAM1 3.0381097138467 4.40362891630201e-24 -1.15161178404697 1.76180407652893e-05 TargetScan -0.25520477479076 1.34349018578279e-08 NA NA NA hsa-miR-1-3p VEGFA -1.48412019995919 0.000242034342580425 0.230749341603949 0.311300638391058 MirTarget -0.172921089301484 3.76698090411866e-10 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-101-3p VEGFA 1.38889039459232 1.96522549511542e-09 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.184546125824104 3.21659312920503e-05 NA NA NA hsa-miR-125a-3p VEGFA -1.04954492275266 2.45974219476832e-06 0.230749341603949 0.311300638391058 miRanda -0.155505773345232 0.000854677712414177 22768249 Ectopic expression of MiR 125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF; Furthermore miR-125a expression was inversely correlated with both MMP11 and VEGF-A expression in HCC tissues; MiR-125a inhibits the proliferation and metastasis of HCC by targeting MMP11 and VEGF-A metastasis liver cancer hsa-miR-133a-3p VEGFA -2.89609207852024 1.71222048144972e-13 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.104720990536239 5.4001689907379e-05 NA NA NA hsa-miR-140-5p VEGFA 0.669142684153918 0.000335928403032308 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.246162039129829 1.79001025551982e-05 26402430 MicroRNA 140 5p inhibits the progression of colorectal cancer by targeting VEGFA; The direct regulation of VEGFA by miR-140-5p was identified using luciferase reporter assay; Integrated analysis identified VEGFA as a direct and functional target gene of miR-140-5p; Silencing VEGFA by small interfering RNA siRNA resembled the phenotype resulting from ectopic miR-140-5p expression while overexpression of VEGFA attenuated the effect of miR-140-5p on CRC cells; Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA progression;tumorigenesis colorectal cancer hsa-miR-150-5p VEGFA -0.702328520623782 0.0215316651134431 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase -0.211938415847961 3.12072029375035e-10 NA NA NA hsa-miR-15b-5p VEGFA -1.25935038177398 1.83460220856901e-12 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget -0.119640608007297 0.0381907284369183 22904162 TaqMan qRT-PCR was used to assess the expression of the selected miRNAs related to angiogenesis miR-15b -16 -17-5p -20a -21 -125a -200b -210 -214* -221 -222 and -424 and VEGF-A and TSP-1 mRNAs were assessed by qRT-PCR using SYBR Green endometrial cancer hsa-miR-195-5p VEGFA -1.01577502605386 4.80814718341729e-05 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget -0.216253591570711 7.05557590450539e-07 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-29c-3p VEGFA 1.32354490728858 1.84279305179762e-07 0.230749341603949 0.311300638391058 miRNAWalker2_validate;MirTarget -0.189793475587463 2.81724907347383e-06 NA NA NA hsa-miR-330-3p VEGFA -0.716924999893351 0.000796236278616087 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.385541553437526 4.9599607016426e-16 NA NA NA hsa-miR-335-5p VEGFA -0.466533891325811 0.0676987038122831 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.139733266743143 0.00237085343344445 NA NA NA hsa-miR-361-5p VEGFA 0.21454431962475 0.0800957579368424 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.311546652005902 0.000341919545726308 NA NA NA hsa-miR-374a-3p VEGFA 1.73882813668241 1.57901646296214e-13 0.230749341603949 0.311300638391058 MirTarget -0.116308302225143 0.0073756212717737 23679262 Our data demonstrated miR-374a to be differentially distributed in breast cancer; VEGF-A and VCAM-1 mRNA had coincident distribution and the distribution of teh respective proteins was uneven and opposite to that for the miR-374a breast cancer hsa-miR-374a-5p VEGFA -0.197027254874826 0.298080902192861 0.230749341603949 0.311300638391058 MirTarget -0.195164100931073 0.0017653451750918 23679262 Our data demonstrated miR-374a to be differentially distributed in breast cancer; VEGF-A and VCAM-1 mRNA had coincident distribution and the distribution of teh respective proteins was uneven and opposite to that for the miR-374a breast cancer hsa-miR-374b-5p VEGFA 0.474691035780475 0.0109217471394203 0.230749341603949 0.311300638391058 MirTarget -0.165654325982956 0.00541935782229369 NA NA NA hsa-miR-378a-3p VEGFA -2.0140903990983 1.146745431034e-18 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase -0.188122556602091 1.9053920640873e-05 NA NA NA hsa-miR-27b-3p VEGFC 0.236438984240408 0.12263510345883 -0.994908041109909 0.000325237653433729 MirTarget -0.206770545439801 0.0146895947025967 23593282 We identified vascular endothelial growth factor C VEGFC as a novel target gene of miR-27b and determined that miR-27b functioned as an inhibitor of tumor progression and angiogenesis through targeting VEGFC in CRC; In summary an anti-tumor role for miR-27b and its novel target VEGFC in vivo could lead to tumor necrosis and provide a rationale for developing miR-27b as a therapeutic agent progression colorectal cancer hsa-miR-194-5p WTIP 1.76979641760284 8.2064222072696e-05 -0.856928783139321 0.00130491225143346 mirMAP -0.108651506026952 5.94815496484425e-05 NA NA NA hsa-miR-185-3p ZAP70 -0.377490365509078 0.093653288903368 0.259007064216141 0.43650040592914 MirTarget -0.24389860060102 0.000337914141917241 NA NA NA hsa-miR-194-5p ZFHX4 1.76979641760284 8.2064222072696e-05 0.209039155051782 0.625267281563143 MirTarget;miRNATAP -0.107357552202374 0.0135412556499048 NA NA NA