miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-16-5p AADAT 0.468459442059375 0.02635007201346 -0.430821792780901 0.0749760085183994 miRNAWalker2_validate -0.280137487754655 5.84024636391147e-05 NA NA NA hsa-miR-16-5p ABCB5 0.468459442059375 0.02635007201346 -0.955542170385081 0.040765415736202 MirTarget -1.05952901960627 1.61605815421718e-16 NA NA NA hsa-miR-16-5p ABCC1 0.468459442059375 0.02635007201346 0.338085547833431 0.00383599185957183 miRNAWalker2_validate -0.101120807811114 0.00289539760508998 NA NA NA hsa-let-7b-5p ABL1 0.16896311055967 0.160596228583843 -0.214581652674921 0.0780394697492818 miRNAWalker2_validate -0.184482981300719 0.00351141291746355 NA NA NA hsa-miR-128-3p ABL1 0.835320684237761 1.85756253116961e-09 -0.214581652674921 0.0780394697492818 MirTarget -0.27216070508526 1.33664511473554e-07 NA NA NA hsa-miR-136-5p ABL1 0.501768051727903 0.0272130411225693 -0.214581652674921 0.0780394697492818 mirMAP -0.141628401422839 1.16717468278428e-05 NA NA NA hsa-miR-141-3p ABL1 1.76274853293464 9.99331900755725e-07 -0.214581652674921 0.0780394697492818 MirTarget -0.218111503076449 4.55639971572044e-35 NA NA NA hsa-miR-142-5p ABL1 1.08445947321046 0.000126372881543671 -0.214581652674921 0.0780394697492818 MirTarget -0.169000159317547 1.39424457953837e-11 NA NA NA hsa-miR-15b-3p ABL1 0.811179945491507 0.000927520880593552 -0.214581652674921 0.0780394697492818 MirTarget -0.215850548581065 6.00783090069401e-14 NA NA NA hsa-miR-15b-5p ABL1 0.637819606405168 0.000580041575431604 -0.214581652674921 0.0780394697492818 mirMAP -0.247975899700418 1.50628736846788e-10 NA NA NA hsa-miR-16-5p ABL1 0.468459442059375 0.02635007201346 -0.214581652674921 0.0780394697492818 mirMAP -0.249348604550532 1.41526789822687e-13 NA NA NA hsa-miR-19a-3p ABL1 1.71062381299889 1.72281025366819e-11 -0.214581652674921 0.0780394697492818 mirMAP -0.196770335641938 2.49936383213114e-13 NA NA NA hsa-miR-200a-3p ABL1 2.02394729844446 2.21240501925011e-08 -0.214581652674921 0.0780394697492818 MirTarget -0.203458594312446 2.97713654349307e-30 NA NA NA hsa-miR-203a-3p ABL1 0.986535065247669 0.00954714606545506 -0.214581652674921 0.0780394697492818 miRTarBase -0.147346955898373 1.00226106539485e-15 21454413 Treatment of lymphoma B cells with demethylating agents led to increased miR-203 expression and the concomitant downregulation of ABL1 confirming the epigenetic regulation of this miRNA; In summary our results show that the transformation from gastritis to MALT lymphoma is epigenetically regulated by miR-203 promoter methylation and identify ABL1 as a novel target for the treatment of this malignancy lymphoma hsa-miR-26a-2-3p ABL1 0.0619487388777404 0.765401751442771 -0.214581652674921 0.0780394697492818 mirMAP -0.144082181852407 7.05487545107894e-05 NA NA NA hsa-miR-29a-3p ABL1 -0.235052170104117 0.138527567930958 -0.214581652674921 0.0780394697492818 miRNAWalker2_validate;miRNATAP -0.237878480720472 3.15023794327729e-07 NA NA NA hsa-miR-29a-5p ABL1 1.00715634051951 4.47499137997344e-07 -0.214581652674921 0.0780394697492818 MirTarget -0.211329484239633 3.03949301472394e-09 NA NA NA hsa-miR-29b-3p ABL1 0.0225365195743876 0.914313337784307 -0.214581652674921 0.0780394697492818 miRNATAP -0.240569013981557 2.29600914538651e-12 NA NA NA hsa-miR-29c-3p ABL1 -1.34143813218298 2.77493790306384e-12 -0.214581652674921 0.0780394697492818 miRNATAP -0.103868544218714 0.00527370062010167 NA NA NA hsa-miR-30b-5p ABL1 -0.0106833209203501 0.954966272944722 -0.214581652674921 0.0780394697492818 MirTarget;miRNATAP -0.136603739672069 0.000526573843878128 NA NA NA hsa-miR-30d-5p ABL1 0.26829866064717 0.0228954180095085 -0.214581652674921 0.0780394697492818 MirTarget;miRNATAP -0.242591978515716 0.000152989341045012 NA NA NA hsa-miR-30e-5p ABL1 -0.284839730810255 0.0405852891523165 -0.214581652674921 0.0780394697492818 MirTarget;miRNATAP -0.334916937063473 1.83885256503207e-10 NA NA NA hsa-miR-3127-5p ABL1 1.27228064385006 2.39461777008663e-07 -0.214581652674921 0.0780394697492818 MirTarget -0.223671005486793 1.30901726698378e-15 NA NA NA hsa-miR-330-5p ABL1 0.621676971901542 0.00233177378595631 -0.214581652674921 0.0780394697492818 MirTarget -0.262577588691945 3.32778784481919e-14 NA NA NA hsa-miR-342-3p ABL1 0.235422340773149 0.290471946350276 -0.214581652674921 0.0780394697492818 miRNAWalker2_validate -0.121927328208738 0.000247651315206866 NA NA NA hsa-miR-361-5p ABL1 0.538048008019709 1.61165802415302e-07 -0.214581652674921 0.0780394697492818 miRanda -0.196849752491814 0.00719571577500416 NA NA NA hsa-miR-423-5p ABL1 0.554579912507932 7.65114789083517e-05 -0.214581652674921 0.0780394697492818 MirTarget -0.216195524711378 4.07175934213918e-05 NA NA NA hsa-miR-455-3p ABL1 1.12209231899143 0.00131487017648489 -0.214581652674921 0.0780394697492818 MirTarget -0.125955637209517 7.21855232796122e-10 NA NA NA hsa-miR-484 ABL1 0.401753773460753 0.0490851523101605 -0.214581652674921 0.0780394697492818 miRNAWalker2_validate -0.210423510217017 3.18740532596468e-09 NA NA NA hsa-miR-503-5p ABL1 1.76009641313699 2.96580674020209e-09 -0.214581652674921 0.0780394697492818 mirMAP -0.119424194986997 1.98096065108553e-06 NA NA NA hsa-miR-16-5p ABL2 0.468459442059375 0.02635007201346 0.820053510414726 8.89463322803119e-15 miRNAWalker2_validate;MirTarget;miRNATAP -0.132667608646662 3.26719434988602e-05 NA NA NA hsa-miR-16-5p ABTB2 0.468459442059375 0.02635007201346 0.158887921869035 0.335857735487359 MirTarget -0.133515832577909 0.00518904886626496 NA NA NA hsa-miR-16-5p ACSBG1 0.468459442059375 0.02635007201346 -0.888245169055709 4.20985642335772e-05 MirTarget -0.570184734500668 3.70974891334774e-22 NA NA NA hsa-miR-16-5p ACTB 0.468459442059375 0.02635007201346 -0.247183413092236 0.0173597292223771 miRNAWalker2_validate -0.163077534767565 3.02541984850391e-08 NA NA NA hsa-miR-16-5p ACTN1 0.468459442059375 0.02635007201346 0.144220815927838 0.446062625714916 miRNAWalker2_validate -0.496262794307697 8.17814313065507e-23 NA NA NA hsa-miR-16-5p ACVR2A 0.468459442059375 0.02635007201346 -0.409014715537696 0.000390733013426116 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.203956484766576 4.34784957003667e-10 NA NA NA hsa-miR-16-5p ACVR2B 0.468459442059375 0.02635007201346 0.479263794953631 0.00365312140717121 miRNATAP -0.118677280753533 0.0136650480876575 NA NA NA hsa-miR-16-5p ADAMTS18 0.468459442059375 0.02635007201346 3.26280400969973 2.5262880435359e-19 miRNATAP -0.244639532435864 0.031330974118321 NA NA NA hsa-miR-16-5p ADAMTS3 0.468459442059375 0.02635007201346 0.381745529837852 0.0472261904397674 miRNATAP -0.310967057841851 1.21719782464708e-08 NA NA NA hsa-miR-16-5p ADAMTS5 0.468459442059375 0.02635007201346 0.188190214805037 0.2771550462378 miRNATAP -0.276019274614413 1.78676682565846e-08 NA NA NA hsa-miR-16-5p ADAMTSL3 0.468459442059375 0.02635007201346 -1.55905070705917 3.51494202991297e-06 MirTarget -0.861071644619396 1.11665113322294e-20 NA NA NA hsa-miR-16-5p ADCY2 0.468459442059375 0.02635007201346 -1.52957881268437 3.68996645479601e-05 mirMAP -1.02767333801464 6.45758028734737e-25 NA NA NA hsa-miR-16-5p ADCY5 0.468459442059375 0.02635007201346 -1.84103992569989 1.33834751194577e-05 MirTarget;miRNATAP -1.1904608544884 1.04626295432719e-25 NA NA NA hsa-miR-16-5p ADRB2 0.468459442059375 0.02635007201346 -2.77607289745493 7.42075616046658e-20 MirTarget -0.450687263710372 1.55189001320559e-06 NA NA NA hsa-miR-16-5p AFF4 0.468459442059375 0.02635007201346 -0.266238435778205 0.0156473179650327 MirTarget;miRNATAP -0.214131383476994 3.16136929955011e-12 NA NA NA hsa-miR-16-5p AGPAT4 0.468459442059375 0.02635007201346 0.0930866987009771 0.613205838182191 mirMAP -0.400692797765968 2.46049373939322e-15 NA NA NA hsa-miR-16-5p AHNAK2 0.468459442059375 0.02635007201346 -0.5905150352765 0.13881539538977 miRNAWalker2_validate -1.14283786958369 8.50462998869559e-28 NA NA NA hsa-miR-16-5p AK4 0.468459442059375 0.02635007201346 -1.11655840159903 0.00017402069474046 MirTarget;miRNATAP -0.470818238052336 3.5996740819749e-08 NA NA NA hsa-miR-16-5p AKAP11 0.468459442059375 0.02635007201346 0.196284041245934 0.098252789597144 MirTarget;miRNATAP -0.18900776980321 1.78186556840174e-08 NA NA NA hsa-miR-16-5p AKT3 0.468459442059375 0.02635007201346 -0.273001052722672 0.188651193580836 miRNAWalker2_validate;miRTarBase;miRNATAP -0.568045037958797 4.87003529234726e-25 NA NA NA hsa-miR-16-5p AMOTL1 0.468459442059375 0.02635007201346 -0.486379931315175 0.054603870149297 MirTarget;miRNATAP -0.655033423559791 5.60952749818319e-22 NA NA NA hsa-miR-100-5p ANAPC1 -0.343735526262058 0.133995182819209 0.696029457995502 8.24411062777403e-10 miRNAWalker2_validate -0.169965984536178 2.4713627762748e-08 NA NA NA hsa-miR-26b-5p ANAPC1 -0.499493687076043 0.0118149973400486 0.696029457995502 8.24411062777403e-10 miRNAWalker2_validate -0.144674699226227 5.06952301601306e-05 NA NA NA hsa-miR-495-3p ANAPC1 -0.024887553302567 0.897251687801771 0.696029457995502 8.24411062777403e-10 MirTarget -0.124542756980903 0.000809291965967208 NA NA NA hsa-miR-16-5p ANAPC16 0.468459442059375 0.02635007201346 -0.562573593594966 5.30708721594642e-08 miRNAWalker2_validate -0.133403180798246 1.05663603834152e-05 NA NA NA hsa-miR-30a-5p ANAPC5 -0.742755040631906 3.79943871404435e-05 0.234998108885475 0.00391277802117259 miRNAWalker2_validate -0.140919256574757 1.49091046948399e-07 NA NA NA hsa-miR-139-5p ANAPC7 -1.41674256628297 4.51005988644234e-14 0.295600257822522 0.000170386470600417 miRanda -0.132432816549771 3.34647924302491e-08 NA NA NA hsa-miR-16-5p ANK2 0.468459442059375 0.02635007201346 -1.60257109400243 5.33587507985444e-06 MirTarget;miRNATAP -1.02543043080236 9.68151112455906e-28 NA NA NA hsa-miR-16-5p ANKRD29 0.468459442059375 0.02635007201346 -1.34789320693404 8.2268003911958e-06 MirTarget -0.510116331142788 4.52471494130292e-09 NA NA NA hsa-miR-16-5p ANKS1A 0.468459442059375 0.02635007201346 -0.13350994800444 0.229491244188813 MirTarget -0.263875693618492 1.69093884989013e-18 NA NA NA hsa-miR-16-5p ANO3 0.468459442059375 0.02635007201346 -0.681632892778825 0.155509818355017 MirTarget;miRNATAP -0.279606945485908 0.0455326677329417 NA NA NA hsa-miR-16-5p AR 0.468459442059375 0.02635007201346 -1.55428586679464 3.79681953414866e-06 mirMAP;miRNATAP -0.985299423793118 4.0929212877286e-28 NA NA NA hsa-miR-16-5p ARHGAP20 0.468459442059375 0.02635007201346 -1.37521379031409 6.54964322003788e-07 MirTarget;miRNATAP -0.749706268759072 2.49972574018994e-23 NA NA NA hsa-miR-16-5p ARHGAP5 0.468459442059375 0.02635007201346 -0.123874599542773 0.263036005478456 MirTarget;miRNATAP -0.208724281495104 1.24890444391077e-11 NA NA NA hsa-miR-16-5p ARHGEF12 0.468459442059375 0.02635007201346 0.0895782409826751 0.356931527604922 MirTarget -0.169069719593881 5.05897920487556e-10 NA NA NA hsa-miR-16-5p ARHGEF9 0.468459442059375 0.02635007201346 -0.626478540461318 1.70542084501607e-07 miRNATAP -0.229852556109099 1.91276185584546e-11 NA NA NA hsa-miR-16-5p ARIH1 0.468459442059375 0.02635007201346 0.0230997107313007 0.793468726040202 MirTarget -0.124231973860522 6.28916792792315e-07 NA NA NA hsa-miR-16-5p ARL10 0.468459442059375 0.02635007201346 -0.28129009619869 0.198316212901093 miRNAWalker2_validate -0.49022807682267 3.0821964200579e-16 NA NA NA hsa-miR-16-5p ARL3 0.468459442059375 0.02635007201346 -0.521628086406404 2.45297123307517e-07 miRNAWalker2_validate;MirTarget -0.117945656861165 6.78184953395905e-05 NA NA NA hsa-miR-16-5p ARL8B 0.468459442059375 0.02635007201346 -0.208090655274296 0.0111650980017705 MirTarget;miRNATAP -0.16107193656259 1.41608120676058e-12 NA NA NA hsa-miR-16-5p ARMCX2 0.468459442059375 0.02635007201346 -0.772079447220427 0.00112319033532053 miRNAWalker2_validate;MirTarget;miRNATAP -0.534759640458762 3.65784441596427e-16 NA NA NA hsa-miR-16-5p ARNT2 0.468459442059375 0.02635007201346 -0.332178452162526 0.258506029820392 mirMAP -0.257436814504623 0.00249497162104775 NA NA NA hsa-miR-16-5p ARVCF 0.468459442059375 0.02635007201346 0.320195968561741 0.0554679301005034 mirMAP -0.272537126201118 8.69654732981037e-09 NA NA NA hsa-miR-16-5p ASB1 0.468459442059375 0.02635007201346 -0.275456210497773 0.00868427409528013 MirTarget -0.208201865313652 1.05281754015906e-12 NA NA NA hsa-miR-16-5p ASH1L 0.468459442059375 0.02635007201346 0.106845282951007 0.300475098931278 miRNAWalker2_validate;MirTarget;miRNATAP -0.203737909252467 9.85099715433403e-13 NA NA NA hsa-miR-16-5p ASTN1 0.468459442059375 0.02635007201346 -2.38850445662267 1.79346320545124e-05 MirTarget -1.23133459556003 3.02139035164133e-15 NA NA NA hsa-miR-16-5p ATF7 0.468459442059375 0.02635007201346 0.0674049536109402 0.438061225007579 miRNAWalker2_validate -0.21963798681548 2.29549682421675e-21 NA NA NA hsa-miR-16-5p ATG14 0.468459442059375 0.02635007201346 0.00414748208186211 0.968361225112142 miRNAWalker2_validate;MirTarget;miRNATAP -0.274272248431266 4.2565184346948e-23 NA NA NA hsa-miR-16-5p ATL2 0.468459442059375 0.02635007201346 -0.383786242998031 0.000575339633888933 miRNAWalker2_validate -0.246662461946968 1.23832748375884e-15 NA NA NA hsa-miR-125a-3p ATM 0.0862037949225951 0.688453004025032 0.177849811817311 0.2156767159682 miRanda -0.1628669430806 7.62120337537398e-05 NA NA NA hsa-miR-186-5p ATM 0.35512789129261 0.0196931838168008 0.177849811817311 0.2156767159682 mirMAP -0.236055566978731 4.14521339122904e-05 NA NA NA hsa-miR-18a-5p ATM 2.04701000113742 1.30593450319289e-12 0.177849811817311 0.2156767159682 miRNAWalker2_validate;miRTarBase;MirTarget -0.106088412949694 0.000233162954700209 23437304;25963391;23857602;23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression colorectal cancer;cervical and endocervical cancer;breast cancer;colon cancer hsa-miR-19b-3p ATM 0.936987029203338 9.28141970787798e-06 0.177849811817311 0.2156767159682 miRNAWalker2_validate -0.101416375959996 0.0132830020347779 NA NA NA hsa-miR-203a-3p ATM 0.986535065247669 0.00954714606545506 0.177849811817311 0.2156767159682 MirTarget -0.115403296072754 2.66140590690965e-07 27542403;24145123 MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression;miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM metastasis;drug resistance gastric cancer;colorectal cancer hsa-miR-26a-5p ATM -0.507487084157331 3.23715933371269e-05 0.177849811817311 0.2156767159682 MirTarget -0.260172318657783 0.000304699607416999 24211747 MiR 26a enhances the radiosensitivity of glioblastoma multiforme cells through targeting of ataxia telangiectasia mutated; Mechanistically this effect is mediated by direct targeting of miR-26a to the 3'UTR of ATM which leads to reduced ATM levels and consequent inhibition of the homologous recombination repair pathway glioblastoma hsa-miR-26b-5p ATM -0.499493687076043 0.0118149973400486 0.177849811817311 0.2156767159682 MirTarget -0.28829637184455 1.3577512320118e-11 NA NA NA hsa-miR-27a-5p ATM 0.59763448976729 0.00736257811879899 0.177849811817311 0.2156767159682 MirTarget -0.128937108789717 0.000963441669595833 NA NA NA hsa-miR-29a-5p ATM 1.00715634051951 4.47499137997344e-07 0.177849811817311 0.2156767159682 mirMAP -0.158446181487041 0.000220888265045783 NA NA NA hsa-miR-30b-5p ATM -0.0106833209203501 0.954966272944722 0.177849811817311 0.2156767159682 mirMAP -0.202472417717984 1.15268236662823e-05 25202329 However specific miRNAs are downregulated in ATC such as those of the miR-200 and miR-30 families which are important negative regulators of cell migration invasion and epithelial-to-mesenchymal transition EMT processes that are overactivated in ATC cell migration thyroid cancer hsa-miR-30d-3p ATM 0.0608340295673737 0.708110230223927 0.177849811817311 0.2156767159682 mirMAP -0.139639670010025 0.010596842202583 24345332 miR-30d has been observed to be significantly down-regulated in human anaplastic thyroid carcinoma ATC and is believed to be an important event in thyroid cell transformation; In this study we found that miR-30d has a critical role in modulating sensitivity of ATC cells to cisplatin a commonly used chemotherapeutic drug for treatment of this neoplasm; Using a mimic of miR-30d we demonstrated that miR-30d could negatively regulate the expression of beclin 1 a key autophagy gene leading to suppression of the cisplatin-activated autophagic response that protects ATC cells from apoptosis; We further showed that inhibition of the beclin 1-mediated autophagy by the miR-30d mimic sensitized ATC cells to cisplatin both in vitro cell culture and in vivo animal xenograft model; These results suggest that dysregulation of miR-30d in ATC cells is responsible for the insensitivity to cisplatin by promoting autophagic survival; Thus miR-30d may be exploited as a potential target for therapeutic intervention in the treatment of ATC drug resistance;poor survival thyroid cancer hsa-miR-30e-3p ATM -0.444998679251398 0.000501880465265124 0.177849811817311 0.2156767159682 mirMAP -0.2787303955117 4.99920516333649e-05 NA NA NA hsa-miR-324-5p ATM 0.800946351685734 0.00101337664367375 0.177849811817311 0.2156767159682 miRanda -0.194410763089921 2.54762832233874e-08 NA NA NA hsa-miR-339-5p ATM 0.51232205151031 0.0560469213103598 0.177849811817311 0.2156767159682 miRanda -0.13426109192386 3.23996774413599e-05 NA NA NA hsa-miR-3607-3p ATM 0.479939234340415 0.251616873367277 0.177849811817311 0.2156767159682 mirMAP -0.118388838063909 1.81323627835821e-08 NA NA NA hsa-miR-362-3p ATM 0.994614346444282 4.39793878186399e-05 0.177849811817311 0.2156767159682 miRanda -0.109504548916553 0.00284068743345207 NA NA NA hsa-miR-374b-5p ATM 0.00249900187478502 0.985380083859555 0.177849811817311 0.2156767159682 mirMAP -0.144285689908357 0.0280946268775611 NA NA NA hsa-miR-409-3p ATM 1.02296003511803 1.54748197930307e-08 0.177849811817311 0.2156767159682 mirMAP -0.1058888802892 0.0259202803286089 NA NA NA hsa-miR-500a-5p ATM 1.33126717816499 3.1497328652235e-07 0.177849811817311 0.2156767159682 mirMAP -0.107353747366416 0.00106465343269018 NA NA NA hsa-miR-576-5p ATM 0.872721964495849 5.20470410008775e-05 0.177849811817311 0.2156767159682 mirMAP -0.179572094249142 6.09724887639175e-06 NA NA NA hsa-miR-590-3p ATM 0.858742926831233 0.000127281269371976 0.177849811817311 0.2156767159682 miRanda;mirMAP -0.191875713899991 4.91581808648856e-07 NA NA NA hsa-miR-590-5p ATM 0.932604531809045 8.39043954167884e-05 0.177849811817311 0.2156767159682 mirMAP -0.193650997523192 6.69095242773379e-08 NA NA NA hsa-miR-766-3p ATM 0.168886051269712 0.412950041105629 0.177849811817311 0.2156767159682 MirTarget -0.121825525421206 0.00429686536815753 NA NA NA hsa-miR-16-5p ATP2B2 0.468459442059375 0.02635007201346 -1.88676051504383 8.01381000058104e-07 MirTarget;miRNATAP -0.944911794883119 5.0949915963447e-19 NA NA NA hsa-miR-16-5p ATP7A 0.468459442059375 0.02635007201346 -0.238505552773791 0.0260565224422086 MirTarget -0.124730189396658 5.02699863468193e-05 NA NA NA hsa-miR-16-5p ATP8A2 0.468459442059375 0.02635007201346 -1.33015281704727 6.49693770892505e-06 miRNAWalker2_validate -0.306700274688815 0.000402984823107497 NA NA NA hsa-miR-130a-3p ATR 0.218018009582956 0.274232880676821 0.988587270241124 1.69770297317362e-15 mirMAP -0.120151820476428 0.00290745417134941 NA NA NA hsa-miR-30a-5p ATR -0.742755040631906 3.79943871404435e-05 0.988587270241124 1.69770297317362e-15 mirMAP -0.152696747889303 0.00051128785676542 NA NA NA hsa-miR-30b-5p ATR -0.0106833209203501 0.954966272944722 0.988587270241124 1.69770297317362e-15 mirMAP -0.143412455033226 0.000747839253435 NA NA NA hsa-miR-374b-5p ATR 0.00249900187478502 0.985380083859555 0.988587270241124 1.69770297317362e-15 mirMAP -0.174742108454184 0.00352680603376064 NA NA NA hsa-miR-495-3p ATR -0.024887553302567 0.897251687801771 0.988587270241124 1.69770297317362e-15 mirMAP -0.152758467049333 0.000245009326266688 NA NA NA hsa-miR-664a-5p ATR -0.185366485838763 0.391076957229399 0.988587270241124 1.69770297317362e-15 mirMAP -0.156465546572458 3.64711673245374e-05 NA NA NA hsa-miR-16-5p ATXN1L 0.468459442059375 0.02635007201346 -0.0692838660654802 0.432409698959029 miRNATAP -0.135821153329364 4.53294795135525e-08 NA NA NA hsa-miR-16-5p ATXN2 0.468459442059375 0.02635007201346 0.266571196061886 0.000720671732750195 MirTarget;miRNATAP -0.143990113891277 7.31762297823942e-11 NA NA NA hsa-miR-16-5p ATXN7L1 0.468459442059375 0.02635007201346 0.0625942927803105 0.536526011070187 miRNATAP -0.148594689346963 2.11745216486272e-07 NA NA NA hsa-miR-16-5p BACE1 0.468459442059375 0.02635007201346 -0.0959250699806233 0.497546427155974 miRNATAP -0.3594907084583 2.2377182933401e-21 NA NA NA hsa-miR-16-5p BACH2 0.468459442059375 0.02635007201346 -0.153664361619301 0.559092317470499 MirTarget;miRNATAP -0.340532453947548 6.08196941316752e-06 NA NA NA hsa-miR-16-5p BCAP29 0.468459442059375 0.02635007201346 -0.0906430310318083 0.291870498841624 MirTarget -0.173579000373952 2.25282528047e-13 NA NA NA hsa-miR-16-5p BCL2 0.468459442059375 0.02635007201346 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.307544967095245 3.1475788390589e-08 18449891;21336967;24447552;25435430;24598659;18931683;22966344;25623762 miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells drug resistance;;worse prognosis;;;;poor survival;drug resistance gastric cancer;liver cancer;lymphoma;lung cancer;lymphoma;prostate cancer;pancreatic cancer;colon cancer hsa-miR-16-5p BHLHE41 0.468459442059375 0.02635007201346 0.353158422209973 0.127533936542101 miRNATAP -0.344034917459229 1.87223392946303e-07 NA NA NA hsa-miR-16-5p BMX 0.468459442059375 0.02635007201346 -1.36301267548465 7.13244454182066e-07 MirTarget;miRNATAP -0.407217600906153 3.69297279393485e-07 NA NA NA hsa-miR-16-5p BNC2 0.468459442059375 0.02635007201346 -0.491277997679328 0.0998827438687705 miRNAWalker2_validate -0.898406159402283 2.60986571280855e-31 NA NA NA hsa-miR-16-5p BRD3 0.468459442059375 0.02635007201346 0.370170558391524 0.000130397685151564 mirMAP -0.148289195188777 8.36907729000765e-08 NA NA NA hsa-miR-16-5p BRSK2 0.468459442059375 0.02635007201346 0.550284260209954 0.140186259420255 mirMAP -0.446959707194828 3.11735687082285e-05 NA NA NA hsa-miR-16-5p BTBD19 0.468459442059375 0.02635007201346 0.961835296568945 1.05703169179008e-07 mirMAP -0.365774639665989 1.41404644908627e-12 NA NA NA hsa-miR-16-5p BTG2 0.468459442059375 0.02635007201346 -1.7630923979864 5.46944077014254e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.266776184014457 3.46585254910816e-05 NA NA NA hsa-miR-16-5p BTRC 0.468459442059375 0.02635007201346 -0.027346328507087 0.741734122686342 miRNAWalker2_validate;MirTarget;miRNATAP -0.132845602675406 1.10929984506892e-08 NA NA NA hsa-miR-139-5p BUB1 -1.41674256628297 4.51005988644234e-14 2.46924049772694 7.96097244462618e-24 miRanda -0.745676313918675 5.08711306682414e-22 NA NA NA hsa-miR-199a-5p BUB1 0.723739336873244 5.69674696426761e-05 2.46924049772694 7.96097244462618e-24 miRanda -0.200915163484411 0.027350398007579 NA NA NA hsa-miR-139-5p BUB3 -1.41674256628297 4.51005988644234e-14 0.620680561248692 2.32704276953201e-09 miRanda -0.222650587288779 3.25010298862412e-12 NA NA NA hsa-miR-16-5p BVES 0.468459442059375 0.02635007201346 -1.51355443880608 7.967744286549e-06 MirTarget -1.01835817045583 5.66667206777867e-30 NA NA NA hsa-miR-16-5p C15orf52 0.468459442059375 0.02635007201346 -0.7749934427518 0.00649279666461122 mirMAP -0.849896235533607 2.29013957230419e-30 NA NA NA hsa-miR-16-5p C16orf52 0.468459442059375 0.02635007201346 -0.0740715490056836 0.385096294799324 miRNATAP -0.182843065520508 4.18801742102868e-15 NA NA NA hsa-miR-16-5p C1orf21 0.468459442059375 0.02635007201346 -0.727977288966725 9.22717896803663e-05 mirMAP;miRNATAP -0.383195206876469 2.47539170875658e-13 NA NA NA hsa-miR-16-5p CACNA1E 0.468459442059375 0.02635007201346 1.7522562120673 4.35724222478899e-06 MirTarget -0.234073656757333 0.03848542976049 NA NA NA hsa-miR-16-5p CACNA2D1 0.468459442059375 0.02635007201346 -0.846445244760543 0.00675290229856498 miRNAWalker2_validate -0.79692949831392 4.34578947666631e-21 NA NA NA hsa-miR-16-5p CACNB2 0.468459442059375 0.02635007201346 -1.05668882228159 0.000454628609880799 miRNAWalker2_validate -0.954622658386906 7.74339910759152e-35 NA NA NA hsa-miR-16-5p CACNB4 0.468459442059375 0.02635007201346 -1.05630266128413 0.000199554767655941 miRNATAP -0.566117558300052 1.57254557372925e-12 NA NA NA hsa-miR-16-5p CADM1 0.468459442059375 0.02635007201346 -0.899936241890849 0.000844138987328649 miRNAWalker2_validate;miRTarBase;miRNATAP -0.318970685413952 4.56350601031325e-05 NA NA NA hsa-miR-16-5p CALM1 0.468459442059375 0.02635007201346 -0.784429149792681 2.03164806777006e-14 miRNATAP -0.171866818558949 1.74349198269888e-08 NA NA NA hsa-miR-16-5p CALU 0.468459442059375 0.02635007201346 0.67344582166522 5.97080259757143e-10 miRNAWalker2_validate;MirTarget -0.105790725880547 0.00109561188859313 NA NA NA hsa-miR-16-5p CAMK2G 0.468459442059375 0.02635007201346 -0.531707953024434 0.000413134284231954 miRNAWalker2_validate -0.43553950276555 5.59199309165606e-28 NA NA NA hsa-miR-16-5p CAMKV 0.468459442059375 0.02635007201346 0.365121683149714 0.438369214703988 miRNAWalker2_validate;miRNATAP -0.286988880484916 0.0362399238842228 NA NA NA hsa-miR-16-5p CAMSAP1 0.468459442059375 0.02635007201346 0.244651879709817 0.0399081942272141 miRNAWalker2_validate;MirTarget;miRNATAP -0.100783078211527 0.00343987552546894 NA NA NA hsa-miR-16-5p CAMSAP2 0.468459442059375 0.02635007201346 0.423832054082736 0.000532909035924399 miRNATAP -0.285480917484414 2.10743816561263e-17 NA NA NA hsa-miR-16-5p CAPN6 0.468459442059375 0.02635007201346 -1.28977859948282 0.0253718872051572 miRNATAP -0.638494602791968 0.000130246849285373 NA NA NA hsa-miR-16-5p CAPZA2 0.468459442059375 0.02635007201346 -0.190566573954487 0.0877745932002987 miRNAWalker2_validate;MirTarget -0.157846729381732 6.61893330390989e-07 NA NA NA hsa-miR-16-5p CASZ1 0.468459442059375 0.02635007201346 -0.74282009313037 2.13443263629592e-07 MirTarget -0.166150699323537 7.97121217162626e-05 NA NA NA hsa-miR-16-5p CBFA2T3 0.468459442059375 0.02635007201346 -1.22133105486193 6.89171725275405e-06 MirTarget;miRNATAP -0.256721061592604 0.00132481744030849 NA NA NA hsa-miR-16-5p CBL 0.468459442059375 0.02635007201346 0.291219247177072 0.0126694723519977 mirMAP -0.132618655025389 8.0467085962383e-05 NA NA NA hsa-miR-16-5p CBX5 0.468459442059375 0.02635007201346 0.164944902002406 0.244455396933291 miRNATAP -0.111820920776524 0.00637878833693296 NA NA NA hsa-miR-16-5p CCDC144A 0.468459442059375 0.02635007201346 -0.223988875692845 0.668368573068086 mirMAP -0.475420993447929 0.00166912835231612 NA NA NA hsa-miR-16-5p CCDC149 0.468459442059375 0.02635007201346 -0.520398436583311 0.00235869791503379 MirTarget -0.254465652422519 2.09506822425464e-07 NA NA NA hsa-miR-16-5p CCDC6 0.468459442059375 0.02635007201346 0.270451325546948 0.0255492648029981 MirTarget;miRNATAP -0.162733116358977 2.61122495672883e-06 NA NA NA hsa-miR-129-5p CCNA2 -1.61803714443871 4.93214379865694e-06 1.48995831982352 1.89023831234571e-13 miRanda -0.157714141210503 1.33936407740035e-05 NA NA NA hsa-miR-199a-5p CCNA2 0.723739336873244 5.69674696426761e-05 1.48995831982352 1.89023831234571e-13 miRanda -0.22620449569195 0.00159583816381498 NA NA NA hsa-miR-218-5p CCNA2 -0.615157868107884 0.00447149109697709 1.48995831982352 1.89023831234571e-13 MirTarget -0.415705503836213 4.50784822185267e-13 NA NA NA hsa-miR-29c-3p CCNA2 -1.34143813218298 2.77493790306384e-12 1.48995831982352 1.89023831234571e-13 MirTarget -0.263578715804575 4.49390288129408e-05 NA NA NA hsa-miR-139-5p CCNB1 -1.41674256628297 4.51005988644234e-14 1.59912325428486 2.27765661636966e-14 miRanda -0.506948004196529 9.02319793475848e-15 NA NA NA hsa-let-7c-5p CCNB2 -0.148489254129201 0.548077841857242 1.85623242658738 2.96361440399421e-16 miRNAWalker2_validate -0.359402905298589 6.01667879170755e-10 NA NA NA hsa-miR-23b-3p CCNB2 -0.228571473429 0.0553601132069074 1.85623242658738 2.96361440399421e-16 miRNAWalker2_validate -0.520029296926532 3.40435023577918e-05 NA NA NA hsa-miR-195-5p CCND1 -1.07154705036962 4.16544134775761e-08 0.720140419027159 0.000259727836476946 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.270917365501396 6.99604795762646e-06 21350001;26631043;25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma ;;metastasis;poor survival breast cancer;cervical and endocervical cancer;sarcoma hsa-miR-20b-5p CCND1 -0.251408129904656 0.380168040769502 0.720140419027159 0.000259727836476946 MirTarget;miRNATAP -0.181499833751399 1.59769536732368e-05 NA NA NA hsa-miR-29c-3p CCND1 -1.34143813218298 2.77493790306384e-12 0.720140419027159 0.000259727836476946 mirMAP -0.156690297682041 0.0103577380850297 NA NA NA hsa-miR-365a-3p CCND1 -0.801671336684825 1.28258342849568e-06 0.720140419027159 0.000259727836476946 miRNAWalker2_validate;miRTarBase -0.152931546885566 0.036209208118448 NA NA NA hsa-miR-497-5p CCND1 -0.486115215577409 0.00973897247186318 0.720140419027159 0.000259727836476946 MirTarget;miRNATAP -0.194638254202971 0.00265856864276364 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-9-5p CCND1 -0.887069929841985 0.00529865051479737 0.720140419027159 0.000259727836476946 miRNAWalker2_validate -0.13860444352194 0.000243216592859737 NA NA NA hsa-let-7a-3p CCND2 0.283468597868531 0.127007787220086 -0.266828347557643 0.311200298179232 mirMAP -0.371567678699036 1.66719392222442e-05 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7b-3p CCND2 0.377956364821509 0.0061730103051373 -0.266828347557643 0.311200298179232 mirMAP -0.402202198292367 0.0006265673802009 NA NA NA hsa-let-7f-1-3p CCND2 1.09636075438131 3.42037366931931e-10 -0.266828347557643 0.311200298179232 mirMAP -0.421511592056269 1.88495018273279e-06 NA NA NA hsa-let-7f-5p CCND2 0.300925310468863 0.0221019558342241 -0.266828347557643 0.311200298179232 miRNATAP -0.346620357429191 0.00536667928289417 NA NA NA hsa-let-7g-5p CCND2 0.296128761926282 0.0296823495976068 -0.266828347557643 0.311200298179232 miRNATAP -0.520425112934185 1.17109619787272e-05 NA NA NA hsa-miR-106a-5p CCND2 0.587427028487119 0.00838999163993323 -0.266828347557643 0.311200298179232 miRNATAP -0.174204880562388 0.0158246906330611 NA NA NA hsa-miR-106b-5p CCND2 1.08518388423396 4.82746923373852e-09 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;miRTarBase;miRNATAP -0.583236779534434 7.66528568514347e-13 NA NA NA hsa-miR-10b-3p CCND2 0.448860145188521 0.00703361939318676 -0.266828347557643 0.311200298179232 mirMAP -0.326004457342762 0.000776508252441517 NA NA NA hsa-miR-130b-5p CCND2 1.47709791778827 1.34679413565661e-06 -0.266828347557643 0.311200298179232 mirMAP -0.356434702320189 1.36407707081637e-12 NA NA NA hsa-miR-141-3p CCND2 1.76274853293464 9.99331900755725e-07 -0.266828347557643 0.311200298179232 MirTarget;TargetScan -0.255901572354203 1.68526590919642e-09 NA NA NA hsa-miR-151a-3p CCND2 0.968493853072108 1.28305876770564e-12 -0.266828347557643 0.311200298179232 mirMAP -0.530145130595398 2.77401247065126e-06 NA NA NA hsa-miR-15a-5p CCND2 1.07800995489566 4.32072598796529e-10 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;miRTarBase;miRNATAP -0.472165099151573 1.14414004078959e-07 NA NA NA hsa-miR-15b-5p CCND2 0.637819606405168 0.000580041575431604 -0.266828347557643 0.311200298179232 miRNATAP -0.516489712340691 8.53499810619317e-10 NA NA NA hsa-miR-16-2-3p CCND2 0.869267463341732 0.000785361809327569 -0.266828347557643 0.311200298179232 mirMAP -0.395226309980272 3.27988952149559e-11 NA NA NA hsa-miR-16-5p CCND2 0.468459442059375 0.02635007201346 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;miRNATAP -0.516132357400658 2.11146706317975e-12 NA NA NA hsa-miR-17-5p CCND2 1.57209612312313 5.10453838016207e-11 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.301614795379694 2.3679331749879e-06 NA NA NA hsa-miR-181a-2-3p CCND2 0.761758815767271 3.4163207928657e-06 -0.266828347557643 0.311200298179232 mirMAP -0.245234247483269 0.0118441456744301 NA NA NA hsa-miR-182-5p CCND2 1.73826081735237 5.69817940588551e-09 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;miRTarBase;miRNATAP -0.337872116023098 2.21608132770386e-11 NA NA NA hsa-miR-183-5p CCND2 2.08412478942637 1.08931431254487e-10 -0.266828347557643 0.311200298179232 miRNATAP -0.315775206761385 8.35703763428762e-12 NA NA NA hsa-miR-185-5p CCND2 1.20157041272762 3.03584066444936e-15 -0.266828347557643 0.311200298179232 MirTarget;miRNATAP -0.504279725930662 3.95675575027617e-07 NA NA NA hsa-miR-186-5p CCND2 0.35512789129261 0.0196931838168008 -0.266828347557643 0.311200298179232 mirMAP;miRNATAP -0.482985631115684 4.61104498921406e-06 NA NA NA hsa-miR-188-5p CCND2 1.57437249320621 2.78824007819973e-08 -0.266828347557643 0.311200298179232 PITA;mirMAP -0.284821735797616 6.47899773985816e-07 NA NA NA hsa-miR-191-5p CCND2 1.00768250372273 1.6683382013374e-05 -0.266828347557643 0.311200298179232 MirTarget -0.30302138483538 6.11450636907225e-06 NA NA NA hsa-miR-19a-3p CCND2 1.71062381299889 1.72281025366819e-11 -0.266828347557643 0.311200298179232 MirTarget;miRNATAP -0.266590112566253 9.32456075860399e-06 NA NA NA hsa-miR-19b-3p CCND2 0.936987029203338 9.28141970787798e-06 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;MirTarget;miRNATAP -0.347119617809494 2.8600708950686e-06 NA NA NA hsa-miR-200a-3p CCND2 2.02394729844446 2.21240501925011e-08 -0.266828347557643 0.311200298179232 MirTarget -0.219287797903635 2.3044254482718e-07 NA NA NA hsa-miR-20a-5p CCND2 1.57190995476158 8.72275528729458e-12 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;miRTarBase;miRNATAP -0.225612289455958 0.000751726268016441 NA NA NA hsa-miR-21-3p CCND2 1.87780012411493 8.38052480155167e-17 -0.266828347557643 0.311200298179232 mirMAP -0.307356816380523 3.60292632960926e-06 NA NA NA hsa-miR-2355-3p CCND2 0.101789577163865 0.693158423682028 -0.266828347557643 0.311200298179232 miRNATAP -0.157835076491116 0.0157147007005435 NA NA NA hsa-miR-26a-2-3p CCND2 0.0619487388777404 0.765401751442771 -0.266828347557643 0.311200298179232 mirMAP -0.182180566976712 0.0217151994827193 NA NA NA hsa-miR-26a-5p CCND2 -0.507487084157331 3.23715933371269e-05 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.344937807080709 0.00960894332117683 NA NA NA hsa-miR-26b-5p CCND2 -0.499493687076043 0.0118149973400486 -0.266828347557643 0.311200298179232 mirMAP;miRNATAP -0.345312855192381 1.73514462922748e-05 NA NA NA hsa-miR-29a-5p CCND2 1.00715634051951 4.47499137997344e-07 -0.266828347557643 0.311200298179232 mirMAP -0.182159842353673 0.0218809184565078 24130168;22330340 We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC;In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator ; gastric cancer;sarcoma hsa-miR-29b-3p CCND2 0.0225365195743876 0.914313337784307 -0.266828347557643 0.311200298179232 MirTarget;miRNATAP -0.210269851977998 0.00652543437036925 24130168;22330340 We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC;In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator ; gastric cancer;sarcoma hsa-miR-301a-3p CCND2 1.22580753116505 5.84016077664577e-09 -0.266828347557643 0.311200298179232 miRNAWalker2_validate -0.360576735570157 8.69435503941875e-07 NA NA NA hsa-miR-3065-3p CCND2 -0.00685158653722073 0.979081293235379 -0.266828347557643 0.311200298179232 MirTarget;miRNATAP -0.195896970627541 0.00146414341100635 NA NA NA hsa-miR-30e-3p CCND2 -0.444998679251398 0.000501880465265124 -0.266828347557643 0.311200298179232 mirMAP -0.264578867443002 0.0383806221737476 NA NA NA hsa-miR-320a CCND2 0.451741078692272 0.00893327237386749 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;mirMAP;miRNATAP -0.29462773696815 0.0015958349522217 NA NA NA hsa-miR-320b CCND2 1.21733873788625 7.99882585998487e-07 -0.266828347557643 0.311200298179232 mirMAP;miRNATAP -0.360458427482597 7.75494430819454e-09 NA NA NA hsa-miR-323a-3p CCND2 0.308398343176418 0.29758426681013 -0.266828347557643 0.311200298179232 miRNATAP -0.142895041606599 0.0127859472840689 NA NA NA hsa-miR-324-3p CCND2 0.903513852828114 7.41223794911022e-07 -0.266828347557643 0.311200298179232 miRNAWalker2_validate -0.370821862924607 1.63600931085595e-05 NA NA NA hsa-miR-331-5p CCND2 0.703863188605486 4.25406757208802e-05 -0.266828347557643 0.311200298179232 miRNATAP -0.460664182751042 5.50959293469208e-07 NA NA NA hsa-miR-335-5p CCND2 0.576542642348884 0.01886326850059 -0.266828347557643 0.311200298179232 miRNAWalker2_validate -0.226680120351377 0.000529223705272384 NA NA NA hsa-miR-33a-3p CCND2 0.21453033253985 0.371591474252951 -0.266828347557643 0.311200298179232 MirTarget -0.269105519919619 0.000115590594987793 NA NA NA hsa-miR-3607-3p CCND2 0.479939234340415 0.251616873367277 -0.266828347557643 0.311200298179232 mirMAP -0.119250048528772 0.00252486402934898 NA NA NA hsa-miR-374b-3p CCND2 0.286271228061054 0.169086077672581 -0.266828347557643 0.311200298179232 mirMAP -0.211778548565297 0.00851440143083975 NA NA NA hsa-miR-423-5p CCND2 0.554579912507932 7.65114789083517e-05 -0.266828347557643 0.311200298179232 miRNAWalker2_validate -0.492335489509232 1.57346886934602e-05 NA NA NA hsa-miR-424-5p CCND2 0.956135912596328 0.00035164943928494 -0.266828347557643 0.311200298179232 miRNATAP -0.244612937037276 3.39142248190113e-05 NA NA NA hsa-miR-429 CCND2 1.58250682050303 4.75828087352234e-05 -0.266828347557643 0.311200298179232 miRNATAP -0.201473724008651 7.13833700723638e-07 NA NA NA hsa-miR-500a-5p CCND2 1.33126717816499 3.1497328652235e-07 -0.266828347557643 0.311200298179232 mirMAP -0.313038292150231 1.31135877186835e-07 NA NA NA hsa-miR-501-5p CCND2 1.59306197632625 2.04856600619363e-09 -0.266828347557643 0.311200298179232 PITA;mirMAP;miRNATAP -0.330162641494821 4.26778581733722e-08 NA NA NA hsa-miR-503-5p CCND2 1.76009641313699 2.96580674020209e-09 -0.266828347557643 0.311200298179232 MirTarget -0.157878219724021 0.00422430184661587 25860935 We then identified two targets of miR-503 CCND2 and CCND3 breast cancer hsa-miR-550a-5p CCND2 1.55643544666056 8.53097422057455e-09 -0.266828347557643 0.311200298179232 MirTarget -0.379829000694252 2.57680359355204e-11 NA NA NA hsa-miR-577 CCND2 0.615893340074725 0.210494450869356 -0.266828347557643 0.311200298179232 PITA;mirMAP -0.150091119883405 2.07008309558727e-05 NA NA NA hsa-miR-589-3p CCND2 1.00357906465313 8.20399071001461e-05 -0.266828347557643 0.311200298179232 mirMAP -0.256663229095903 8.69400409941881e-05 NA NA NA hsa-miR-590-3p CCND2 0.858742926831233 0.000127281269371976 -0.266828347557643 0.311200298179232 miRanda;mirMAP -0.418266898886136 1.66524099584715e-09 NA NA NA hsa-miR-590-5p CCND2 0.932604531809045 8.39043954167884e-05 -0.266828347557643 0.311200298179232 mirMAP -0.356627609219485 6.26678679589055e-08 NA NA NA hsa-miR-660-5p CCND2 1.23607536548029 2.61099214897472e-10 -0.266828347557643 0.311200298179232 mirMAP -0.277964804570177 0.000471101509058194 NA NA NA hsa-miR-7-1-3p CCND2 0.94398354303717 7.5771319809992e-05 -0.266828347557643 0.311200298179232 mirMAP -0.264403230513261 6.47028686057144e-05 NA NA NA hsa-miR-877-5p CCND2 1.86786864338556 8.44059777969251e-10 -0.266828347557643 0.311200298179232 miRNAWalker2_validate -0.320187750770132 3.21509092017468e-09 NA NA NA hsa-miR-93-5p CCND2 1.68243825551104 4.62947431501061e-15 -0.266828347557643 0.311200298179232 miRNATAP -0.296309342090127 2.63797997444733e-05 NA NA NA hsa-miR-96-5p CCND2 1.44821155854693 6.56312590328933e-06 -0.266828347557643 0.311200298179232 TargetScan;miRNATAP -0.289502666598185 1.60886469433295e-08 NA NA NA hsa-miR-125b-5p CCNE1 -0.176364454911029 0.43771853581292 1.63902722877652 2.5095106440044e-08 miRNAWalker2_validate -0.328507585771565 4.93685520157516e-05 NA NA NA hsa-miR-195-5p CCNE1 -1.07154705036962 4.16544134775761e-08 1.63902722877652 2.5095106440044e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.508445516091264 1.96888625792722e-08 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-26a-5p CCNE1 -0.507487084157331 3.23715933371269e-05 1.63902722877652 2.5095106440044e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.32553784083694 0.0336914156199607 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-497-5p CCNE1 -0.486115215577409 0.00973897247186318 1.63902722877652 2.5095106440044e-08 MirTarget;miRNATAP -0.422371825297681 1.45931369873543e-05 24112607;25909221;24909281 Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells;miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1 ;; breast cancer;lung cancer;cervical and endocervical cancer hsa-miR-26a-5p CCNE2 -0.507487084157331 3.23715933371269e-05 1.11137025866778 3.37127377164225e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.217991130222279 0.0187235945588459 24116110;21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression poor survival;progression pancreatic cancer;acute myeloid leukemia hsa-miR-28-3p CCNE2 -0.247525872199168 0.0399632425440147 1.11137025866778 3.37127377164225e-10 PITA;miRNATAP -0.463382853367312 7.31596729214753e-07 NA NA NA hsa-miR-30a-5p CCNE2 -0.742755040631906 3.79943871404435e-05 1.11137025866778 3.37127377164225e-10 miRNATAP -0.477869968613217 2.56757628817536e-16 NA NA NA hsa-miR-23b-3p CCNH -0.228571473429 0.0553601132069074 -0.197428676241081 0.0234911296226969 MirTarget -0.11723858485141 0.0100951043403969 NA NA NA hsa-miR-16-5p CCPG1 0.468459442059375 0.02635007201346 -0.206345981982444 0.045354236212813 miRNAWalker2_validate -0.13131185205609 8.29075568089282e-06 NA NA NA hsa-miR-16-5p CD44 0.468459442059375 0.02635007201346 0.22322903953021 0.302952719713054 miRNAWalker2_validate -0.178229991933679 0.00451403769175094 NA NA NA hsa-miR-16-5p CDADC1 0.468459442059375 0.02635007201346 -0.175403878216009 0.0980480368715214 miRNAWalker2_validate -0.118755960636389 9.36053955679181e-05 NA NA NA hsa-let-7b-3p CDC14A 0.377956364821509 0.0061730103051373 -0.460900334459796 0.000189739666126241 mirMAP -0.121468568979727 0.0299747994196744 NA NA NA hsa-let-7f-1-3p CDC14A 1.09636075438131 3.42037366931931e-10 -0.460900334459796 0.000189739666126241 mirMAP -0.158528955799692 0.000169324956686114 NA NA NA hsa-miR-421 CDC14A 1.26653675546617 2.35180826009926e-08 -0.460900334459796 0.000189739666126241 miRanda -0.100647006567389 0.00229150373891914 NA NA NA hsa-miR-493-5p CDC14A 1.32223598235404 3.01688809960418e-10 -0.460900334459796 0.000189739666126241 miRNATAP -0.113487303208831 0.00119256509337356 NA NA NA hsa-miR-193a-5p CDC14B 0.048285104969974 0.725663104619603 -0.186132542609082 0.0984381413809061 miRNATAP -0.102546749230939 0.0444282948482735 NA NA NA hsa-miR-30e-3p CDC14B -0.444998679251398 0.000501880465265124 -0.186132542609082 0.0984381413809061 MirTarget -0.110398004208012 0.0426755467543926 NA NA NA hsa-miR-23b-3p CDC20 -0.228571473429 0.0553601132069074 2.00820731565322 4.98235544760216e-14 miRNAWalker2_validate -0.657233488778352 6.34939441544698e-06 NA NA NA hsa-miR-30a-5p CDC20 -0.742755040631906 3.79943871404435e-05 2.00820731565322 4.98235544760216e-14 miRNAWalker2_validate -0.713179316875314 1.885999593235e-15 NA NA NA hsa-miR-125a-5p CDC23 -0.261743402170195 0.116107665196876 0.256370026574242 0.00132700475415603 miRanda -0.11375291830756 0.000104627865405628 NA NA NA hsa-miR-29c-3p CDC23 -1.34143813218298 2.77493790306384e-12 0.256370026574242 0.00132700475415603 miRNAWalker2_validate -0.139984126927587 4.20613745545422e-09 NA NA NA hsa-let-7c-5p CDC25A -0.148489254129201 0.548077841857242 1.56346598354421 9.99488105357483e-12 MirTarget -0.432741218142878 2.04304254183925e-14 25909324 MicroRNA let 7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma; The aim of the present study was to determine whether the cell cycle regulator CDC25A is involved in the antitumor effect of let-7c in HCC; The luciferase reporter assay showed that CDC25A was a direct target of let-7c and that let-7c inhibited the expression of CDC25A protein by directly targeting its 3' UTR; In conclusion this study indicates that let-7c suppresses HCC progression possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules progression liver cancer hsa-miR-195-5p CDC25A -1.07154705036962 4.16544134775761e-08 1.56346598354421 9.99488105357483e-12 MirTarget;miRNATAP -0.432239380619452 1.37481779283584e-09 NA NA NA hsa-miR-497-5p CDC25A -0.486115215577409 0.00973897247186318 1.56346598354421 9.99488105357483e-12 MirTarget;miRNATAP -0.275558926576201 0.000383103786056767 NA NA NA hsa-miR-361-5p CDC26 0.538048008019709 1.61165802415302e-07 -0.428891463904057 9.15069150121813e-07 miRanda -0.143139403938103 0.00731672715720548 NA NA NA hsa-miR-195-5p CDC27 -1.07154705036962 4.16544134775761e-08 0.384273651115161 2.02443424744725e-06 miRNATAP -0.216561688967975 1.27012292328695e-20 NA NA NA hsa-miR-326 CDC27 -0.552187708067123 0.039648668341622 0.384273651115161 2.02443424744725e-06 miRanda -0.10455022294352 8.56793415128734e-09 NA NA NA hsa-miR-497-5p CDC27 -0.486115215577409 0.00973897247186318 0.384273651115161 2.02443424744725e-06 miRNATAP -0.193221124532751 2.70780159906901e-14 NA NA NA hsa-miR-16-5p CDC37L1 0.468459442059375 0.02635007201346 -0.427242848422614 9.3988336440429e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.147579612809277 2.91353099764126e-06 NA NA NA hsa-miR-199a-5p CDC6 0.723739336873244 5.69674696426761e-05 2.33267765608115 8.16987162863573e-17 miRanda -0.243464497422202 0.0158740924793755 NA NA NA hsa-miR-101-3p CDC7 -0.0683272309939689 0.544163124741916 1.64408835572264 7.35301968672814e-20 miRNAWalker2_validate -0.26483022715373 0.0150270872846235 NA NA NA hsa-miR-199a-5p CDC7 0.723739336873244 5.69674696426761e-05 1.64408835572264 7.35301968672814e-20 MirTarget;miRanda -0.141794657328132 0.0311019617239912 NA NA NA hsa-miR-16-5p CDK17 0.468459442059375 0.02635007201346 0.0694540025336501 0.487075282749813 miRNAWalker2_validate;MirTarget;miRNATAP -0.225546949169 1.06971275230007e-16 NA NA NA hsa-miR-23b-3p CDK2 -0.228571473429 0.0553601132069074 0.749435872303729 1.57275104733674e-11 miRNAWalker2_validate -0.16727997063867 0.00572747591909996 NA NA NA hsa-miR-125a-3p CDK6 0.0862037949225951 0.688453004025032 0.990643124320291 1.17862667832619e-06 mirMAP -0.138883963795303 0.021370798857422 NA NA NA hsa-miR-129-5p CDK6 -1.61803714443871 4.93214379865694e-06 0.990643124320291 1.17862667832619e-06 miRNAWalker2_validate -0.138266138688225 0.000101863341844936 24055727 Interestingly we showed that cyclin dependent kinase 6 CDK6 a cell cycle-associated protein involved in G1-S transition was a target of miR-129 gastric cancer hsa-miR-144-3p CDK6 -1.37061426401952 5.85913017989725e-05 0.990643124320291 1.17862667832619e-06 mirMAP -0.101833657078409 0.00635737230618311 NA NA NA hsa-miR-145-3p CDK6 -1.47406550617505 3.24220742398631e-11 0.990643124320291 1.17862667832619e-06 mirMAP -0.344656671453606 1.11915080146253e-10 24510775 miR 145 sensitizes ovarian cancer cells to paclitaxel by targeting Sp1 and Cdk6; In our study paclitaxel-resistant ovarian cancer patients and cell lines had decreased miR-145 levels and expressed high levels of Sp1 and Cdk6; Furthermore we confirmed that both Cdk6 and Sp1 are targets of miR-145; Collectively these findings begin to elucidate the role of miR-145 as an important regulator of chemoresistance in ovarian cancer by controlling both Cdk6 and Sp1 drug resistance ovarian cancer hsa-miR-145-5p CDK6 -1.54503595327403 2.65080161523141e-09 0.990643124320291 1.17862667832619e-06 miRNATAP -0.290716781237802 2.77020181110234e-10 24510775 miR 145 sensitizes ovarian cancer cells to paclitaxel by targeting Sp1 and Cdk6; In our study paclitaxel-resistant ovarian cancer patients and cell lines had decreased miR-145 levels and expressed high levels of Sp1 and Cdk6; Furthermore we confirmed that both Cdk6 and Sp1 are targets of miR-145; Collectively these findings begin to elucidate the role of miR-145 as an important regulator of chemoresistance in ovarian cancer by controlling both Cdk6 and Sp1 drug resistance ovarian cancer hsa-miR-195-5p CDK6 -1.07154705036962 4.16544134775761e-08 0.990643124320291 1.17862667832619e-06 miRNAWalker2_validate;miRTarBase -0.290091435905514 3.96478737812371e-06 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-26b-5p CDK6 -0.499493687076043 0.0118149973400486 0.990643124320291 1.17862667832619e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.158657733610352 0.0134979371521054 NA NA NA hsa-miR-27b-3p CDK6 -0.439806942644624 0.000523870009254693 0.990643124320291 1.17862667832619e-06 mirMAP -0.252639297594135 0.0129354048194692 NA NA NA hsa-miR-29c-3p CDK6 -1.34143813218298 2.77493790306384e-12 0.990643124320291 1.17862667832619e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265226660289665 2.67195043466264e-05 26396669 Furthermore through qPCR and Western blot assays confirmed that overexpression of miR-29c reduced CDK6 mRNA and protein levels; miR-29c could inhibit the proliferation migration and invasion of bladder cancer cells via regulating CDK6 bladder cancer hsa-miR-30a-3p CDK6 -1.27950866170419 4.33230022379782e-09 0.990643124320291 1.17862667832619e-06 miRNAWalker2_validate;miRTarBase;mirMAP -0.25961002788022 3.57594650212499e-06 NA NA NA hsa-miR-30a-5p CDK6 -0.742755040631906 3.79943871404435e-05 0.990643124320291 1.17862667832619e-06 mirMAP -0.245225033410941 0.000435613889393649 NA NA NA hsa-miR-30b-5p CDK6 -0.0106833209203501 0.954966272944722 0.990643124320291 1.17862667832619e-06 mirMAP -0.140953622170833 0.0380634742449815 NA NA NA hsa-miR-374b-5p CDK6 0.00249900187478502 0.985380083859555 0.990643124320291 1.17862667832619e-06 mirMAP -0.207264926074624 0.0297836165909739 NA NA NA hsa-miR-497-5p CDK6 -0.486115215577409 0.00973897247186318 0.990643124320291 1.17862667832619e-06 miRNATAP -0.239968806241616 0.000370608392551898 NA NA NA hsa-miR-9-5p CDK6 -0.887069929841985 0.00529865051479737 0.990643124320291 1.17862667832619e-06 mirMAP -0.142994009007753 0.000289625379889559 NA NA NA hsa-miR-139-5p CDK7 -1.41674256628297 4.51005988644234e-14 0.183847757184596 0.0991229388532307 miRanda -0.105931447946177 0.00214034389466105 NA NA NA hsa-miR-199a-5p CDK7 0.723739336873244 5.69674696426761e-05 0.183847757184596 0.0991229388532307 miRanda -0.117056358329641 0.00177699845321758 NA NA NA hsa-let-7a-5p CDKN1A 0.298659498236324 0.00963231738125113 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate;MirTarget;TargetScan -0.35986665527898 0.000385524311347491 NA NA NA hsa-let-7e-5p CDKN1A 0.227253058773149 0.162290058199053 -1.26866697234787 1.6534116759688e-12 MirTarget -0.183435616986943 0.0101870597831225 NA NA NA hsa-let-7f-5p CDKN1A 0.300925310468863 0.0221019558342241 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate;MirTarget -0.246997976543877 0.00538611588830313 NA NA NA hsa-let-7i-5p CDKN1A 0.90895826823783 5.79676789748755e-17 -1.26866697234787 1.6534116759688e-12 MirTarget -0.394236057392729 0.000101892575632853 NA NA NA hsa-miR-106a-5p CDKN1A 0.587427028487119 0.00838999163993323 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.173640322178151 0.000693869591447925 25510666 After prediction with online software we further used dual-luciferase reporter gene assay to ensure that TP53INP1 and CDKN1A might be the direct targets of miR-106a liver cancer hsa-miR-146b-5p CDKN1A 2.23105707690238 3.83997814011313e-23 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate -0.215180106045082 3.12241828598735e-06 27602131 During the search for potential targets of miR-146b in ATC p21 also known as p21Waf1/Cip1 or CDKN1A was noted for its role in cell cycle progression and tumor pathogenesis progression thyroid cancer hsa-miR-17-5p CDKN1A 1.57209612312313 5.10453838016207e-11 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.191048011916783 2.99245686343416e-05 26482648;24989082 The low expressions of miR-17 and miR-92 families can maintain cisplatin resistance through the regulation of CDKN1A and RAD21;According to PicTar and Miranda algorithms which predicted CDKN1A p21 as a putative target of miR-17 a luciferase assay was performed and revealed that miR-17 directly targets the 3'-UTR of p21 mRNA drug resistance; lung squamous cell cancer;sarcoma hsa-miR-20a-5p CDKN1A 1.57190995476158 8.72275528729458e-12 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.291264058902903 3.74080074414107e-10 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex colon cancer hsa-miR-423-3p CDKN1A 1.0646553568956 2.48410617381049e-08 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate;miRTarBase -0.123274678075497 0.0366109991451148 NA NA NA hsa-miR-423-5p CDKN1A 0.554579912507932 7.65114789083517e-05 -1.26866697234787 1.6534116759688e-12 MirTarget -0.17798518970221 0.0306931514275593 NA NA NA hsa-miR-93-5p CDKN1A 1.68243825551104 4.62947431501061e-15 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.270597575279336 5.19228546193252e-08 25633810 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC liver cancer hsa-miR-98-5p CDKN1A 0.72508924193932 6.07191196761022e-10 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate;MirTarget -0.235995727619112 0.0152793429006797 NA NA NA hsa-miR-140-5p CDKN1B 0.132398579631585 0.457960134430787 -0.0847508653944109 0.424643882738365 miRanda -0.120359491504028 0.000933066953674841 NA NA NA hsa-miR-221-3p CDKN1B 1.11809809289021 6.56903442847056e-08 -0.0847508653944109 0.424643882738365 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.130595918572421 1.50281798728683e-05 23637992;19953484;23939688;19126397;20146005;23967190;17569667;22992757;17721077;20461750 miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression progression;;;;staging;tumorigenesis;;;;;poor survival breast cancer;glioblastoma;breast cancer;melanoma;liver cancer;pancreatic cancer;prostate cancer;breast cancer;glioblastoma;ovarian cancer hsa-miR-222-3p CDKN1B 1.50650995841483 1.51287294049382e-09 -0.0847508653944109 0.424643882738365 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.112013615016007 6.06815852683629e-06 19953484;26912358;24895988;24137356;17569667;27282281;20461750 Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;Besides microvesicle marker characterization we evidenced that miR-222 exosomal expression mostly reflected its abundance in the cells of origin correctly paralleled by repression of its target genes such as p27Kip1 and induction of the PI3K/AKT pathway thus confirming its functional implication in cancer;MiR-222 plays an important role in the tumorigenesis of CC possibly by specifically down-regulating p27Kip1 and PTEN;miR 222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1; miR-222 upregulation induced an enhancement of ovarian cancer cell proliferation potential possibly by downregulating its target P27Kip1; A bioinformatic analysis showed that the 3'-UTR of the P27Kip1 mRNA contained a highly-conserved putative miR-222 binding site; Luciferase reporter assays demonstrated that P27Kip1 was a direct target of miR-222; Consistently there was an inverse correlation between the P27Kip1 and miR-222 expression levels in the ovarian cancer cell lines and tissues;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;miR 222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27kip1 expression; Immunofluorescence showed that miR-222 altered the subcellular location of p27kip1 in nucleus; The results showed that downregulation of miR-222 in MCF-7/Adr increased sensitivity to Adr and Adr-induced apoptosis and arrested the cells in G1 phase accompanied by more expressions of p27kip1 especially in nucleus; Taken together the results found that miR-222 induced Adr-resistance at least in part via suppressing p27kip1 expression and altering its subcellular localization and miR-222 inhibitors could reverse Adr-resistance of breast cancer cells;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression ;;tumorigenesis;;;drug resistance;poor survival glioblastoma;melanoma;cervical and endocervical cancer;ovarian cancer;prostate cancer;breast cancer;ovarian cancer hsa-miR-24-3p CDKN1B 0.425646348491286 0.00136678638934554 -0.0847508653944109 0.424643882738365 miRNAWalker2_validate;miRNATAP -0.321808040925846 1.03857558435644e-11 26847530;26044523 The biological significance of miR-24 expression in prostate cancer cells was assessed by a series of in vitro bioassays and the effect on proposed targets p27 CDKN1B and p16 CDK2NA was investigated;With the bioinformatic method we further identified that p27Kip1 is a direct target of miR-24-3p and its protein level was negatively regulated by miR-24-3p ; prostate cancer;breast cancer hsa-miR-30e-3p CDKN1B -0.444998679251398 0.000501880465265124 -0.0847508653944109 0.424643882738365 MirTarget -0.149276785408705 0.00340664023322551 NA NA NA hsa-miR-505-3p CDKN1B 0.68973424635459 0.00225185811813183 -0.0847508653944109 0.424643882738365 MirTarget -0.119637739674627 2.132964534306e-05 NA NA NA hsa-miR-98-5p CDKN1B 0.72508924193932 6.07191196761022e-10 -0.0847508653944109 0.424643882738365 miRNAWalker2_validate -0.174172818189207 0.00137872817304278 NA NA NA hsa-miR-107 CDKN1C 0.85152957824299 1.22369651446858e-11 -0.928632420664964 0.000334045862808214 miRanda -0.633261825987799 2.37578250548177e-07 NA NA NA hsa-miR-221-3p CDKN1C 1.11809809289021 6.56903442847056e-08 -0.928632420664964 0.000334045862808214 miRNAWalker2_validate;miRTarBase;miRNATAP -0.414380286867562 2.09630942787707e-08 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-222-3p CDKN1C 1.50650995841483 1.51287294049382e-09 -0.928632420664964 0.000334045862808214 miRNAWalker2_validate;miRTarBase;miRNATAP -0.403283014902986 1.80882130234873e-11 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-25-3p CDKN1C 0.948739680210032 3.62304579611938e-09 -0.928632420664964 0.000334045862808214 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.289636369092635 0.0029306777177117 NA NA NA hsa-miR-32-5p CDKN1C 0.425717775201634 0.0402079308210921 -0.928632420664964 0.000334045862808214 MirTarget;miRNATAP -0.214858970182423 0.00538172151672337 NA NA NA hsa-miR-320b CDKN1C 1.21733873788625 7.99882585998487e-07 -0.928632420664964 0.000334045862808214 miRanda;miRNATAP -0.214036460860897 0.000723184594747365 NA NA NA hsa-miR-34a-5p CDKN1C 0.691825068787607 0.00069818668499891 -0.928632420664964 0.000334045862808214 miRNATAP -0.541314650807171 4.6066199991569e-13 NA NA NA hsa-miR-429 CDKN1C 1.58250682050303 4.75828087352234e-05 -0.928632420664964 0.000334045862808214 miRNATAP -0.228050136170325 1.27221730916861e-08 NA NA NA hsa-miR-450b-5p CDKN1C 1.36137774989901 7.45499130609203e-11 -0.928632420664964 0.000334045862808214 miRNATAP -0.196795364788865 0.00779561578869902 NA NA NA hsa-miR-590-3p CDKN1C 0.858742926831233 0.000127281269371976 -0.928632420664964 0.000334045862808214 miRanda -0.456285449233285 2.57881994212253e-11 NA NA NA hsa-miR-92a-3p CDKN1C 1.06124545165614 6.51550014372282e-08 -0.928632420664964 0.000334045862808214 MirTarget;miRNATAP -0.321520257810737 4.82191060112235e-05 NA NA NA hsa-miR-92b-3p CDKN1C 1.10163066523605 4.43024463410466e-10 -0.928632420664964 0.000334045862808214 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.201533660642613 0.0225503885736784 NA NA NA hsa-miR-107 CDKN2B 0.85152957824299 1.22369651446858e-11 -0.489024427953435 0.0538076657781151 PITA -0.286354300271462 0.018354091735174 NA NA NA hsa-miR-16-5p CDS2 0.468459442059375 0.02635007201346 -0.264082281986768 0.0124768267475766 miRNAWalker2_validate;mirMAP;miRNATAP -0.241895356509056 5.77962287961018e-17 NA NA NA hsa-miR-16-5p CEP63 0.468459442059375 0.02635007201346 -0.0968385672273597 0.218950942044022 miRNAWalker2_validate -0.136269506694957 5.44068188490879e-10 NA NA NA hsa-miR-16-5p CFL2 0.468459442059375 0.02635007201346 -1.29748949709607 2.10137209702745e-06 miRNAWalker2_validate -0.82612686830472 3.39764783290628e-30 NA NA NA hsa-miR-16-5p CHD3 0.468459442059375 0.02635007201346 -0.00056985963877132 0.99669087955822 miRNAWalker2_validate -0.161264269513139 4.1409387796195e-05 NA NA NA hsa-miR-16-5p CHD5 0.468459442059375 0.02635007201346 -0.922474137133441 0.0152054367268636 miRNATAP -0.935333083145399 1.45074346804214e-19 NA NA NA hsa-miR-16-5p CHD9 0.468459442059375 0.02635007201346 -0.255057088271817 0.0209229203314752 miRNATAP -0.256591587346628 1.60568056124898e-17 NA NA NA hsa-miR-129-5p CHEK1 -1.61803714443871 4.93214379865694e-06 1.31371493705371 1.44136781815912e-17 miRanda -0.125907020477424 6.6258894308615e-06 NA NA NA hsa-miR-139-5p CHEK1 -1.41674256628297 4.51005988644234e-14 1.31371493705371 1.44136781815912e-17 miRanda -0.404311184903971 4.88032251715264e-17 NA NA NA hsa-miR-195-5p CHEK1 -1.07154705036962 4.16544134775761e-08 1.31371493705371 1.44136781815912e-17 MirTarget;miRNATAP -0.398348011078744 4.46376910732843e-17 25840419 MiR 195 suppresses non small cell lung cancer by targeting CHEK1; We discovered that CHEK1 was a direct target of miR-195 which decreased CHEK1 expression in lung cancer cells lung squamous cell cancer hsa-miR-497-5p CHEK1 -0.486115215577409 0.00973897247186318 1.31371493705371 1.44136781815912e-17 MirTarget;miRNATAP -0.333703009385831 1.16278024270774e-10 24464213 Checkpoint kinase 1 is negatively regulated by miR 497 in hepatocellular carcinoma; In silico analysis showed that CHEK1 was a candidate target of miR-497 which was previously found to be downregulated in HCC by us; To test whether miR-497 could bind to 3'untranslated region 3'UTR of CHEK1 luciferase reporter assay was conducted; The result revealed that miR-497 could bind to the 3'untranslated region 3'UTR of CHEK1 mRNA; Western blot showed that ectopic expression of miR-497 suppressed the CHEK1 expression and inhibition of miR-497 led to significant upregulation of CHEK1; Finally miR-497 expression was measured in the same 30 HCC samples and the correlation between miR-497 and CHEK1 was analyzed; The results indicated that miR-497 was downregulated in HCC and had a significant negative correlation with CHEK1; Taken together these results demonstrated that CHEK1 was negatively regulated by miR-497 and the overexpressed CHEK1 was resulted from the downregulated miR-497 in HCC which provided a potential molecular target for HCC therapy liver cancer hsa-miR-16-5p CLASP1 0.468459442059375 0.02635007201346 0.0864210099182321 0.350450750205728 miRNAWalker2_validate -0.197384595525743 6.80566548027004e-15 NA NA NA hsa-miR-16-5p CLOCK 0.468459442059375 0.02635007201346 -0.103747140891207 0.347345002981963 MirTarget -0.134620428300819 1.95177787953249e-05 NA NA NA hsa-miR-16-5p CNKSR2 0.468459442059375 0.02635007201346 -1.84738040911148 0.000144389883049721 miRNATAP -1.33020798427442 2.6065224941877e-24 NA NA NA hsa-miR-16-5p CNN1 0.468459442059375 0.02635007201346 -2.63261128854596 3.50101583516012e-07 miRNATAP -1.52686367670466 2.30577538418923e-28 NA NA NA hsa-miR-16-5p CNN3 0.468459442059375 0.02635007201346 -0.562615101587786 0.000315898705221665 miRNAWalker2_validate -0.26700016498424 1.97939451512183e-09 NA NA NA hsa-miR-16-5p CNTNAP1 0.468459442059375 0.02635007201346 0.357666658494201 0.137267058981739 MirTarget -0.604306186330414 1.2840945307249e-20 NA NA NA hsa-miR-16-5p COL12A1 0.468459442059375 0.02635007201346 1.85024755694303 1.80226749421741e-14 MirTarget;miRNATAP -0.324085442655662 8.97521325308437e-06 NA NA NA hsa-miR-16-5p COL24A1 0.468459442059375 0.02635007201346 0.0627518396785927 0.830857580241174 MirTarget;miRNATAP -0.592549955561772 3.78332331123896e-13 NA NA NA hsa-miR-16-5p COL4A1 0.468459442059375 0.02635007201346 1.78756439655909 1.15160259120415e-19 miRNAWalker2_validate -0.154435330020513 0.0121553308385016 NA NA NA hsa-miR-16-5p COL4A2 0.468459442059375 0.02635007201346 1.02334447820144 1.14936313463397e-07 miRNAWalker2_validate -0.282823841850533 5.33266269478467e-07 NA NA NA hsa-miR-16-5p COL4A3BP 0.468459442059375 0.02635007201346 -0.442702454360006 7.43848955821672e-07 MirTarget;miRNATAP -0.161233498725285 2.64526714343472e-10 NA NA NA hsa-miR-16-5p COL4A4 0.468459442059375 0.02635007201346 0.203566165779439 0.562717703881247 mirMAP -0.439780736121142 1.2927402552007e-05 NA NA NA hsa-miR-16-5p COLQ 0.468459442059375 0.02635007201346 -0.0281705177858252 0.88881327375582 MirTarget -0.388007488481874 4.89227433526505e-12 NA NA NA hsa-miR-16-5p COPS2 0.468459442059375 0.02635007201346 -0.177690858514008 0.0497397118986118 MirTarget -0.132268336558853 2.53002060336263e-07 NA NA NA hsa-miR-16-5p CPEB2 0.468459442059375 0.02635007201346 -0.814992840745196 1.51604703202433e-10 miRNATAP -0.291375379714284 8.29731963129453e-16 NA NA NA hsa-miR-16-5p CPEB3 0.468459442059375 0.02635007201346 -0.726462801367756 6.97488351116509e-10 MirTarget;miRNATAP -0.186506027897577 6.47981733388126e-08 NA NA NA hsa-miR-16-5p CPNE8 0.468459442059375 0.02635007201346 0.0062044767507774 0.974298258402277 miRNAWalker2_validate -0.37587275763501 2.32803003731012e-12 NA NA NA hsa-miR-16-5p CREB3L2 0.468459442059375 0.02635007201346 -0.525060002905056 1.65437910930531e-05 miRNAWalker2_validate -0.183482969404046 1.770961248215e-07 NA NA NA hsa-miR-16-5p CREB5 0.468459442059375 0.02635007201346 0.0144734137836222 0.953004773309416 miRNATAP -0.43058273916855 4.50409890129185e-10 NA NA NA hsa-let-7a-3p CREBBP 0.283468597868531 0.127007787220086 0.12609198135211 0.151856717161953 miRNATAP -0.126832065443874 9.09830479242066e-06 NA NA NA hsa-miR-186-5p CREBBP 0.35512789129261 0.0196931838168008 0.12609198135211 0.151856717161953 mirMAP;miRNATAP -0.124895130184274 0.000391994576616712 NA NA NA hsa-miR-26a-5p CREBBP -0.507487084157331 3.23715933371269e-05 0.12609198135211 0.151856717161953 miRNATAP -0.13086170126049 0.00298543969633216 NA NA NA hsa-miR-26b-5p CREBBP -0.499493687076043 0.0118149973400486 0.12609198135211 0.151856717161953 miRNATAP -0.114487766466716 1.73366112934079e-05 NA NA NA hsa-miR-330-5p CREBBP 0.621676971901542 0.00233177378595631 0.12609198135211 0.151856717161953 miRanda -0.10346690969793 6.3023620889252e-05 NA NA NA hsa-miR-374a-3p CREBBP 0.0703956336838676 0.602396227448772 0.12609198135211 0.151856717161953 miRNATAP -0.168861785882399 2.33223934084548e-05 NA NA NA hsa-miR-590-3p CREBBP 0.858742926831233 0.000127281269371976 0.12609198135211 0.151856717161953 PITA;miRanda;mirMAP;miRNATAP -0.137565790660827 2.28574154348559e-09 NA NA NA hsa-miR-16-5p CREBL2 0.468459442059375 0.02635007201346 -0.289272671162855 0.00289044434753105 miRNAWalker2_validate -0.143426374227248 2.1685555972751e-07 NA NA NA hsa-miR-16-5p CREBRF 0.468459442059375 0.02635007201346 -0.366122742256368 0.00726639317725131 MirTarget;miRNATAP -0.41164232353014 1.89116167943136e-31 NA NA NA hsa-miR-16-5p CRHBP 0.468459442059375 0.02635007201346 -1.86592532904734 1.09075192248574e-08 miRNAWalker2_validate -0.503409137223867 1.43052642786584e-07 NA NA NA hsa-miR-16-5p CRIM1 0.468459442059375 0.02635007201346 0.197285946805334 0.189438220015135 MirTarget;miRNATAP -0.305512614256775 2.30864747547938e-13 NA NA NA hsa-miR-16-5p CRTC3 0.468459442059375 0.02635007201346 0.163968910454066 0.167864898428982 miRNATAP -0.230112949866966 3.43021640166327e-12 NA NA NA hsa-miR-16-5p CSDE1 0.468459442059375 0.02635007201346 -0.493287553628065 9.33208346703344e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.221966869783644 4.7732039656455e-18 NA NA NA hsa-miR-16-5p CSGALNACT1 0.468459442059375 0.02635007201346 0.0158656866116087 0.920206408463859 miRNAWalker2_validate -0.192645298437882 2.14265610438092e-05 NA NA NA hsa-miR-16-5p CSRNP1 0.468459442059375 0.02635007201346 -1.44806555350895 9.29266738210502e-17 MirTarget -0.17385171503421 0.00117204764770798 NA NA NA hsa-miR-16-5p CSRNP2 0.468459442059375 0.02635007201346 0.2407958778036 0.00292801865987127 miRNATAP -0.110332846317089 1.72947665067787e-06 NA NA NA hsa-miR-16-5p CTDSPL 0.468459442059375 0.02635007201346 0.0846519426294803 0.451210027493253 miRNATAP -0.182132590228328 8.56014826161749e-09 NA NA NA hsa-miR-16-5p CYS1 0.468459442059375 0.02635007201346 -1.28136910647413 0.000362306307876932 mirMAP -0.942002015126119 3.69853776785707e-22 NA NA NA hsa-miR-195-3p DBF4 -0.694544351365025 0.000214711021317786 1.35173364501309 5.91594020445588e-20 mirMAP -0.380273176466365 1.13096130111555e-14 NA NA NA hsa-miR-30a-5p DBF4 -0.742755040631906 3.79943871404435e-05 1.35173364501309 5.91594020445588e-20 MirTarget -0.430337686661691 1.39900940896499e-17 NA NA NA hsa-miR-16-5p DCAF5 0.468459442059375 0.02635007201346 -0.432022552798976 2.11919388779901e-08 MirTarget;miRNATAP -0.135523552150841 9.13147547748019e-10 NA NA NA hsa-miR-16-5p DCLK1 0.468459442059375 0.02635007201346 -1.32352503962546 0.000138162205768269 miRNATAP -0.839752683019201 1.61411711103512e-18 NA NA NA hsa-miR-16-5p DCUN1D4 0.468459442059375 0.02635007201346 -0.256427886046376 0.0215922527238607 MirTarget;miRNATAP -0.234210119034957 3.20741403405358e-14 NA NA NA hsa-miR-16-5p DCX 0.468459442059375 0.02635007201346 -0.844677817637489 0.10668674687843 mirMAP -0.992999060899347 1.33027051730101e-11 NA NA NA hsa-miR-16-5p DDHD2 0.468459442059375 0.02635007201346 -0.154583103342212 0.193842372532219 miRNAWalker2_validate -0.212804790810022 1.68958303130421e-10 NA NA NA hsa-miR-16-5p DDX3Y 0.468459442059375 0.02635007201346 -1.08011892315372 0.269270157228425 miRNAWalker2_validate;MirTarget;miRNATAP -0.66920952393031 0.0185771728362028 NA NA NA hsa-miR-16-5p DDX6 0.468459442059375 0.02635007201346 0.0909600078885502 0.364279387413942 miRNAWalker2_validate -0.209148556035941 3.26265217044136e-14 NA NA NA hsa-miR-16-5p DENND4A 0.468459442059375 0.02635007201346 0.0639973705197328 0.546412201539267 MirTarget -0.145583005879473 1.34590632926609e-06 NA NA NA hsa-miR-16-5p DEPTOR 0.468459442059375 0.02635007201346 -0.636660583221345 0.000625271809267951 MirTarget -0.117103900622873 0.0319818320732698 NA NA NA hsa-miR-16-5p DICER1 0.468459442059375 0.02635007201346 0.0423646248128726 0.674000051094903 miRNAWalker2_validate -0.108205280679886 0.000173309016346085 NA NA NA hsa-miR-16-5p DIXDC1 0.468459442059375 0.02635007201346 -1.16493051519743 1.82036516809915e-06 miRNAWalker2_validate;MirTarget -0.804235115488361 1.12228823615132e-37 NA NA NA hsa-miR-16-5p DLC1 0.468459442059375 0.02635007201346 -0.381837238292576 0.0503828744141603 miRNAWalker2_validate -0.468245704376486 1.16893028966203e-18 NA NA NA hsa-miR-16-5p DLL1 0.468459442059375 0.02635007201346 -0.367321557272473 0.0311156953180708 miRNATAP -0.140478660492966 0.00451926292143064 NA NA NA hsa-miR-16-5p DMD 0.468459442059375 0.02635007201346 -1.50584693629303 4.05157194167937e-06 miRNAWalker2_validate -0.988960775179143 2.00865789895759e-30 NA NA NA hsa-miR-16-5p DMTF1 0.468459442059375 0.02635007201346 0.248049933973103 0.0272588092258348 miRNAWalker2_validate;MirTarget;miRNATAP -0.121877150071894 0.000163687149650316 NA NA NA hsa-miR-16-5p DNAJA4 0.468459442059375 0.02635007201346 0.274133991463733 0.132162668434715 miRNAWalker2_validate -0.11717947112649 0.0268020149074682 NA NA NA hsa-miR-16-5p DNAJB4 0.468459442059375 0.02635007201346 -0.699790825105696 7.61829706903065e-06 miRNAWalker2_validate -0.451813321978953 2.00875649078104e-27 NA NA NA hsa-miR-16-5p DOCK4 0.468459442059375 0.02635007201346 0.502120813551762 0.00108492735386023 MirTarget -0.212377296652345 1.56092278704462e-06 NA NA NA hsa-miR-16-5p DOCK9 0.468459442059375 0.02635007201346 0.119962941828406 0.352682724173672 miRNAWalker2_validate -0.172788158672847 2.63379697296121e-06 NA NA NA hsa-miR-16-5p DRD1 0.468459442059375 0.02635007201346 0.226592195703944 0.647536682501484 MirTarget;miRNATAP -0.533775745013277 0.000185612046972112 NA NA NA hsa-miR-16-5p DSEL 0.468459442059375 0.02635007201346 -0.67285265642764 0.0053381936162325 MirTarget;miRNATAP -0.611023464127672 1.0078823744594e-20 NA NA NA hsa-miR-16-5p DUSP3 0.468459442059375 0.02635007201346 -0.535283506428631 4.81242862721625e-05 MirTarget;miRNATAP -0.345528402467881 3.41810339834798e-22 NA NA NA hsa-miR-16-5p DYNC1I1 0.468459442059375 0.02635007201346 -1.12027945318246 0.00107388621207106 MirTarget;miRNATAP -0.86565440500228 1.60390565985401e-20 NA NA NA hsa-miR-16-5p DYNC1LI2 0.468459442059375 0.02635007201346 -0.151678434580852 0.11155732630237 MirTarget;miRNATAP -0.263713047268442 4.88822306654969e-26 NA NA NA hsa-miR-16-5p DYNLT3 0.468459442059375 0.02635007201346 -0.106104625502022 0.423267882184853 MirTarget -0.180671881152922 1.67965305002396e-06 NA NA NA hsa-miR-16-5p DYRK1A 0.468459442059375 0.02635007201346 -0.0929124816843609 0.267127060752188 miRNATAP -0.122202910933621 2.29966904941693e-07 NA NA NA hsa-miR-16-5p DZIP1 0.468459442059375 0.02635007201346 -0.88362320879615 0.00028568683997458 MirTarget -0.660790980105154 5.98257294559773e-24 NA NA NA hsa-miR-23b-3p E2F1 -0.228571473429 0.0553601132069074 1.76058262330901 3.12040752345955e-20 miRNAWalker2_validate -0.452115927849991 2.46929093399817e-05 NA NA NA hsa-let-7c-5p E2F2 -0.148489254129201 0.548077841857242 1.3644011732819 3.48960652938848e-07 MirTarget -0.416596292555655 2.54460494043302e-10 NA NA NA hsa-let-7e-5p E2F2 0.227253058773149 0.162290058199053 1.3644011732819 3.48960652938848e-07 MirTarget -0.28688616837259 0.00585450505984302 NA NA NA hsa-miR-125a-5p E2F2 -0.261743402170195 0.116107665196876 1.3644011732819 3.48960652938848e-07 MirTarget -0.323396003343054 0.00140268947668939 NA NA NA hsa-miR-125b-5p E2F2 -0.176364454911029 0.43771853581292 1.3644011732819 3.48960652938848e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.435379160945765 1.45142723700109e-09 22999819 miR 125b regulates the proliferation of glioblastoma stem cells by targeting E2F2; This study demonstrated that miR-125b plays important roles in regulating the proliferation of GSCs by directly targeting E2F2 glioblastoma hsa-miR-20b-5p E2F2 -0.251408129904656 0.380168040769502 1.3644011732819 3.48960652938848e-07 MirTarget;miRNATAP -0.128796017948859 0.0280087882332612 NA NA NA hsa-miR-30c-2-3p E2F2 -0.850499600024184 1.80492410494116e-05 1.3644011732819 3.48960652938848e-07 MirTarget -0.649600053333567 2.01830951799689e-16 NA NA NA hsa-miR-365a-3p E2F2 -0.801671336684825 1.28258342849568e-06 1.3644011732819 3.48960652938848e-07 MirTarget -0.31882218006622 0.00141239332754191 NA NA NA hsa-miR-101-3p E2F3 -0.0683272309939689 0.544163124741916 1.28918854042277 1.74177583223201e-27 miRNAWalker2_validate -0.202220099461638 0.00606026421292292 NA NA NA hsa-miR-10b-5p E2F3 -0.2493192229845 0.144956122242922 1.28918854042277 1.74177583223201e-27 miRNATAP -0.100804891464015 0.0340520432797607 NA NA NA hsa-miR-125a-5p E2F3 -0.261743402170195 0.116107665196876 1.28918854042277 1.74177583223201e-27 PITA;miRanda;miRNATAP -0.125648926105054 0.00997881144563089 NA NA NA hsa-miR-125b-5p E2F3 -0.176364454911029 0.43771853581292 1.28918854042277 1.74177583223201e-27 miRNAWalker2_validate;miRTarBase;miRNATAP -0.147141285186001 2.86696810491838e-05 22523546;20549700 Moreover we demonstrated that the E2F3 was a direct target of miR-125b in breast cancer cells;E2F3 which was critical for G1/S transition and was overexpressed in most of poor-differentiated bladder cancers was identified as a target of miR-125b by luciferase assay; Introduction of miR-125b could reduce the expression of E2F3 protein but not the E2F3 mRNA ; breast cancer;bladder cancer hsa-miR-145-5p E2F3 -1.54503595327403 2.65080161523141e-09 1.28918854042277 1.74177583223201e-27 miRNATAP -0.246937117135053 1.77703613828324e-18 25762621 miR 145 mediates the antiproliferative and gene regulatory effects of vitamin D3 by directly targeting E2F3 in gastric cancer cells; Furthermore miR-145 expression was lower in tumors compared with matched normal samples and correlated with increased the E2F3 transcription factor protein staining gastric cancer hsa-miR-195-5p E2F3 -1.07154705036962 4.16544134775761e-08 1.28918854042277 1.74177583223201e-27 miRNAWalker2_validate;miRTarBase;miRNATAP -0.317627344832083 6.58598738402716e-17 22217655 We identified E2F3 and CCND3 as functional downstream targets of miR-195 in glioblastoma cells glioblastoma hsa-miR-30a-5p E2F3 -0.742755040631906 3.79943871404435e-05 1.28918854042277 1.74177583223201e-27 miRNATAP -0.265139141646024 7.27165231204271e-10 NA NA NA hsa-miR-30c-5p E2F3 -0.172645077009891 0.276411433016536 1.28918854042277 1.74177583223201e-27 miRNAWalker2_validate;miRNATAP -0.104483013480423 0.042426654597781 NA NA NA hsa-miR-497-5p E2F3 -0.486115215577409 0.00973897247186318 1.28918854042277 1.74177583223201e-27 miRNATAP -0.247293489690463 3.12037385356785e-09 NA NA NA hsa-miR-23b-3p E2F4 -0.228571473429 0.0553601132069074 0.171174037983082 0.0399069280914865 miRNAWalker2_validate -0.144553952370893 0.000842494667926536 NA NA NA hsa-let-7c-5p E2F5 -0.148489254129201 0.548077841857242 0.556543885746152 0.000229830635611877 MirTarget -0.189296628171728 3.4552827118545e-07 NA NA NA hsa-miR-1-3p E2F5 -2.73171785118192 3.4424534921136e-12 0.556543885746152 0.000229830635611877 MirTarget -0.145985268051019 2.59816017008545e-11 NA NA NA hsa-miR-16-5p EDA 0.468459442059375 0.02635007201346 -0.372450144691841 0.22226981888951 MirTarget;miRNATAP -0.295533863606906 0.00080805590779757 NA NA NA hsa-miR-16-5p EGFR 0.468459442059375 0.02635007201346 -0.174568357475892 0.484508576205495 miRNAWalker2_validate -0.348371726581681 1.00705856880478e-06 NA NA NA hsa-miR-16-5p EGLN1 0.468459442059375 0.02635007201346 -0.12730652589272 0.153604768279239 MirTarget -0.15672452116794 3.20678173407267e-10 NA NA NA hsa-miR-16-5p EIF4G3 0.468459442059375 0.02635007201346 0.0244390885042307 0.814319234728122 miRNAWalker2_validate -0.172209403325218 3.74927067004461e-09 NA NA NA hsa-miR-16-5p ELL2 0.468459442059375 0.02635007201346 -1.46362215725712 1.58717825670906e-20 MirTarget;miRNATAP -0.189819970811233 0.000106803226172901 NA NA NA hsa-miR-16-5p ELOVL5 0.468459442059375 0.02635007201346 -0.0910045021719972 0.633667869483248 miRNAWalker2_validate -0.263393935043483 1.31206192206368e-06 NA NA NA hsa-miR-16-5p ENAH 0.468459442059375 0.02635007201346 -0.303508505660234 0.0898566571919018 MirTarget;miRNATAP -0.4068129300899 1.06158871426029e-16 NA NA NA hsa-miR-16-5p ENPP4 0.468459442059375 0.02635007201346 -0.190495269838545 0.28985475632262 miRNAWalker2_validate -0.159211214754704 0.00221268151389794 NA NA NA hsa-miR-16-5p ENTPD1 0.468459442059375 0.02635007201346 0.236680596078842 0.0602010987065912 MirTarget -0.276294791104924 1.42817098418098e-15 NA NA NA hsa-miR-26a-5p EP300 -0.507487084157331 3.23715933371269e-05 0.169472319642808 0.0210882946602254 miRNATAP -0.179040051498714 7.75875796633954e-07 NA NA NA hsa-miR-16-5p EPC1 0.468459442059375 0.02635007201346 -0.122635046043363 0.138311155212862 miRNAWalker2_validate -0.142489118610961 7.09615053136465e-10 NA NA NA hsa-miR-16-5p EPHA7 0.468459442059375 0.02635007201346 -2.19739166323181 3.30440512414909e-05 miRNATAP -1.45381695447653 2.29128286174938e-24 NA NA NA hsa-miR-16-5p ERC2 0.468459442059375 0.02635007201346 -0.427257459724932 0.15521309382104 MirTarget;miRNATAP -0.363168714269448 2.63852580872999e-05 NA NA NA hsa-let-7c-5p ESPL1 -0.148489254129201 0.548077841857242 1.56331947733163 1.81289419897426e-09 MirTarget -0.340795341459118 1.81744475326993e-07 NA NA NA hsa-miR-125a-5p ESPL1 -0.261743402170195 0.116107665196876 1.56331947733163 1.81289419897426e-09 miRanda -0.333551486701887 0.000763953019128386 NA NA NA hsa-miR-16-5p EYA1 0.468459442059375 0.02635007201346 -0.459017244802486 0.202570531835921 miRNATAP -0.421699598841627 4.7315290936852e-05 NA NA NA hsa-miR-16-5p EYA4 0.468459442059375 0.02635007201346 0.300366807020702 0.36876153821282 MirTarget -0.595541590078295 2.34198952146379e-10 NA NA NA hsa-miR-16-5p EZH1 0.468459442059375 0.02635007201346 -0.563595010007821 9.54263036009044e-06 MirTarget;miRNATAP -0.350311845017341 1.41715304148468e-24 NA NA NA hsa-miR-16-5p FAM120C 0.468459442059375 0.02635007201346 0.170776103390755 0.263203241775743 MirTarget;miRNATAP -0.24251786561285 1.95152991871082e-08 NA NA NA hsa-miR-16-5p FAM122A 0.468459442059375 0.02635007201346 -0.303994263706123 0.000409216969430765 miRNAWalker2_validate -0.113906212988459 3.89179093696477e-06 NA NA NA hsa-miR-16-5p FAM131A 0.468459442059375 0.02635007201346 -0.453263150372832 0.000487625804146054 mirMAP -0.199465229509127 8.26882637881847e-08 NA NA NA hsa-miR-16-5p FAM161A 0.468459442059375 0.02635007201346 0.184954654544411 0.214390035381984 MirTarget -0.105818750490971 0.0142470624848307 NA NA NA hsa-miR-16-5p FAM168A 0.468459442059375 0.02635007201346 -0.191804273695932 0.128925621940858 miRNAWalker2_validate -0.147799332865353 4.50449465111196e-05 NA NA NA hsa-miR-16-5p FAM189A1 0.468459442059375 0.02635007201346 -2.65743696971689 6.59320514962127e-07 MirTarget;miRNATAP -0.891600882919426 8.31634010568444e-09 NA NA NA hsa-miR-16-5p FAM196A 0.468459442059375 0.02635007201346 -0.288120566953572 0.21491857896918 miRNATAP -0.250969769901979 0.000177812481450574 NA NA NA hsa-miR-16-5p FAM208A 0.468459442059375 0.02635007201346 0.222942633109318 0.0216547406408079 miRNAWalker2_validate -0.103947388095795 0.000195350840390413 NA NA NA hsa-miR-16-5p FAM69A 0.468459442059375 0.02635007201346 -0.657229328548528 2.26012627458719e-07 miRNAWalker2_validate -0.247105956380239 9.17331270466763e-12 NA NA NA hsa-miR-16-5p FAT2 0.468459442059375 0.02635007201346 -0.278356365218703 0.44877423623627 miRNAWalker2_validate -0.410048730730272 0.000106156791850331 NA NA NA hsa-miR-16-5p FAT3 0.468459442059375 0.02635007201346 -1.60082132479507 0.000514379028219012 miRNAWalker2_validate;MirTarget;miRNATAP -1.33478598476398 6.81416091906746e-28 NA NA NA hsa-miR-16-5p FAT4 0.468459442059375 0.02635007201346 -0.353979211281549 0.146937063510268 MirTarget -0.581351997893513 2.07564750112991e-18 NA NA NA hsa-miR-16-5p FBXL20 0.468459442059375 0.02635007201346 0.190290133062633 0.106207235760524 MirTarget -0.274497870766121 1.05415999241895e-17 NA NA NA hsa-miR-16-5p FBXO24 0.468459442059375 0.02635007201346 -0.193290141946342 0.228600488669418 mirMAP -0.146177454138543 0.00162051698608833 NA NA NA hsa-miR-16-5p FBXO3 0.468459442059375 0.02635007201346 -0.554476776198341 4.67339274952818e-11 miRNAWalker2_validate -0.16931190263038 2.86186673910462e-12 NA NA NA hsa-miR-16-5p FCHSD2 0.468459442059375 0.02635007201346 0.068173820585983 0.54665746300611 miRNATAP -0.110108314092813 0.000702930033598017 NA NA NA hsa-miR-16-5p FEM1C 0.468459442059375 0.02635007201346 -0.395479886134297 0.00021224243420561 miRNAWalker2_validate -0.171429155344935 1.83328892600423e-08 NA NA NA hsa-miR-16-5p FERMT2 0.468459442059375 0.02635007201346 -0.896574191403877 0.000646206347161597 MirTarget;miRNATAP -0.811463307004377 1.02426341546694e-32 NA NA NA hsa-miR-16-5p FGF18 0.468459442059375 0.02635007201346 0.577376156575134 0.0408104462212036 miRNATAP -0.369359265698103 5.20931508210512e-06 NA NA NA hsa-miR-16-5p FGF2 0.468459442059375 0.02635007201346 -1.0252152469847 2.26010255795334e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.677411929110591 1.74059869270375e-25 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGF7 0.468459442059375 0.02635007201346 -0.41434019544902 0.185809734564159 miRNATAP -0.821178064931021 1.07301219125421e-22 NA NA NA hsa-miR-16-5p FGF9 0.468459442059375 0.02635007201346 -0.567473807130705 0.17094770957627 miRNATAP -0.292368075720853 0.0152643987915688 NA NA NA hsa-miR-16-5p FGFR1 0.468459442059375 0.02635007201346 -0.509147194592856 0.0395673749466621 miRTarBase;miRNATAP -0.537128465186198 3.99987589014271e-15 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FLCN 0.468459442059375 0.02635007201346 -0.0287679480447434 0.734531988226442 miRNAWalker2_validate -0.102337224911697 2.19398388456621e-05 NA NA NA hsa-miR-16-5p FLNA 0.468459442059375 0.02635007201346 -0.771411398655463 0.0137692934141899 miRNAWalker2_validate -0.940053137809319 7.11178406588357e-31 NA NA NA hsa-miR-16-5p FLYWCH1 0.468459442059375 0.02635007201346 -0.129620772197759 0.188303972310229 mirMAP -0.104896656816343 0.00020277709282911 NA NA NA hsa-miR-16-5p FNBP1 0.468459442059375 0.02635007201346 -0.968853731521844 4.0379880862342e-05 miRNAWalker2_validate -0.564713851318506 4.75113962777329e-18 NA NA NA hsa-miR-16-5p FRMPD1 0.468459442059375 0.02635007201346 -0.602569560944977 0.187845328261471 MirTarget -0.682042347173141 1.67729737641204e-07 NA NA NA hsa-miR-16-5p FRY 0.468459442059375 0.02635007201346 -0.418462380954893 0.0343686444672025 miRNATAP -0.367240341211716 3.86559377249958e-11 NA NA NA hsa-miR-16-5p FZD10 0.468459442059375 0.02635007201346 -0.909941827017163 0.00782584288797018 miRNATAP -0.26974499680618 0.00688587270078794 NA NA NA hsa-miR-16-5p FZD4 0.468459442059375 0.02635007201346 -0.113370323882084 0.480936634316706 MirTarget -0.306428305545196 8.38754425500858e-12 NA NA NA hsa-miR-16-5p GABARAPL1 0.468459442059375 0.02635007201346 -1.20328483426322 2.1183796887727e-11 miRNAWalker2_validate -0.364205125065008 2.86219712382393e-12 NA NA NA hsa-miR-16-5p GABPA 0.468459442059375 0.02635007201346 0.0209115160002433 0.798811912937794 MirTarget -0.124010730502971 7.58320694370613e-08 NA NA NA hsa-miR-421 GADD45A 1.26653675546617 2.35180826009926e-08 -0.46534180449918 0.00041748712734641 miRanda -0.126057568779209 0.000328189175112102 NA NA NA hsa-miR-140-5p GADD45B 0.132398579631585 0.457960134430787 -1.40236926095615 1.67034873496549e-11 miRanda -0.191860608575247 0.0105893174776408 NA NA NA hsa-miR-1976 GADD45B 0.888680419203938 2.16642020734521e-05 -1.40236926095615 1.67034873496549e-11 miRNATAP -0.387413586467079 1.38996179392164e-09 NA NA NA hsa-miR-324-3p GADD45B 0.903513852828114 7.41223794911022e-07 -1.40236926095615 1.67034873496549e-11 MirTarget;miRNATAP -0.464002298421658 1.91655493629672e-11 NA NA NA hsa-miR-590-3p GADD45B 0.858742926831233 0.000127281269371976 -1.40236926095615 1.67034873496549e-11 miRanda -0.405684513938275 5.92191194739096e-13 NA NA NA hsa-miR-107 GADD45G 0.85152957824299 1.22369651446858e-11 -1.01705327515042 3.0262034377882e-06 miRanda -0.497163734843814 1.88973381789475e-06 NA NA NA hsa-miR-127-3p GADD45G 0.480219800701855 0.00500448678268473 -1.01705327515042 3.0262034377882e-06 miRanda;miRNATAP -0.228775664200888 0.00400333727554626 NA NA NA hsa-miR-181a-5p GADD45G 1.39352013383959 4.74824377258519e-17 -1.01705327515042 3.0262034377882e-06 miRNAWalker2_validate -0.473464837525594 2.85890662273293e-10 NA NA NA hsa-miR-1976 GADD45G 0.888680419203938 2.16642020734521e-05 -1.01705327515042 3.0262034377882e-06 MirTarget -0.302830021591979 5.15816116241075e-06 NA NA NA hsa-miR-320b GADD45G 1.21733873788625 7.99882585998487e-07 -1.01705327515042 3.0262034377882e-06 miRanda -0.147758111149599 0.00611968131309538 NA NA NA hsa-miR-421 GADD45G 1.26653675546617 2.35180826009926e-08 -1.01705327515042 3.0262034377882e-06 miRanda -0.136851063770132 0.0204739078650347 NA NA NA hsa-miR-429 GADD45G 1.58250682050303 4.75828087352234e-05 -1.01705327515042 3.0262034377882e-06 miRNATAP -0.158797218700579 3.77977949544582e-06 NA NA NA hsa-miR-502-5p GADD45G 0.873538712251823 0.0012275719769761 -1.01705327515042 3.0262034377882e-06 miRNATAP -0.158071046550152 0.00656118393800075 NA NA NA hsa-miR-16-5p GALNT13 0.468459442059375 0.02635007201346 -0.857168264038236 0.0743939574762176 MirTarget -0.854569455892958 2.84686773439218e-10 NA NA NA hsa-miR-16-5p GFRA2 0.468459442059375 0.02635007201346 -2.58628382037502 1.9202934668223e-14 mirMAP -0.576949052337594 1.09107875266474e-08 NA NA NA hsa-miR-16-5p GHR 0.468459442059375 0.02635007201346 -2.14662589752822 3.10775498765719e-12 MirTarget;miRNATAP -0.858253112380564 1.28699187367759e-23 NA NA NA hsa-miR-16-5p GNAL 0.468459442059375 0.02635007201346 -1.05101187353865 0.000317291051700254 miRNAWalker2_validate;miRNATAP -0.913328020507044 1.02491536087331e-33 NA NA NA hsa-miR-16-5p GNAO1 0.468459442059375 0.02635007201346 -1.85268367495665 6.00392357820662e-06 mirMAP -1.05023811939365 8.71718108847965e-21 NA NA NA hsa-miR-16-5p GOLGA1 0.468459442059375 0.02635007201346 -0.0838742308619249 0.297785765177034 MirTarget;miRNATAP -0.118271298999307 1.87826386625809e-07 NA NA NA hsa-miR-16-5p GOLGA4 0.468459442059375 0.02635007201346 0.0668555129502852 0.601837372774509 MirTarget -0.16810381915907 4.16865098974254e-06 NA NA NA hsa-miR-16-5p GPAM 0.468459442059375 0.02635007201346 0.141794492741679 0.297316336494304 miRNAWalker2_validate -0.126558939509404 0.00125314178393584 NA NA NA hsa-miR-16-5p GPR153 0.468459442059375 0.02635007201346 -0.139533614460711 0.514523373271394 miRNATAP -0.273465741279549 8.070676448918e-06 NA NA NA hsa-miR-16-5p GRAMD3 0.468459442059375 0.02635007201346 -0.455456030185696 7.57079931704227e-05 MirTarget -0.146297622845473 1.12302059328019e-05 NA NA NA hsa-miR-101-3p GSK3B -0.0683272309939689 0.544163124741916 0.265875974150976 0.000454893180511198 miRNATAP -0.108161751914472 0.01087865904704 NA NA NA hsa-miR-26a-5p GSK3B -0.507487084157331 3.23715933371269e-05 0.265875974150976 0.000454893180511198 miRNAWalker2_validate;miRNATAP -0.276398668334029 3.95575891525495e-14 NA NA NA hsa-miR-27b-3p GSK3B -0.439806942644624 0.000523870009254693 0.265875974150976 0.000454893180511198 miRNATAP -0.110459527996732 0.00277108844798185 NA NA NA hsa-miR-28-5p GSK3B -0.22318016376076 0.0194144033008573 0.265875974150976 0.000454893180511198 miRanda;miRNATAP -0.126553177913534 0.0124343156692131 NA NA NA hsa-miR-29a-3p GSK3B -0.235052170104117 0.138527567930958 0.265875974150976 0.000454893180511198 miRNATAP -0.144457662631292 6.53501471959977e-07 NA NA NA hsa-miR-29c-3p GSK3B -1.34143813218298 2.77493790306384e-12 0.265875974150976 0.000454893180511198 miRNATAP -0.155474348899545 3.47249883249066e-12 NA NA NA hsa-miR-30a-3p GSK3B -1.27950866170419 4.33230022379782e-09 0.265875974150976 0.000454893180511198 miRNATAP -0.111611289077542 3.43621966685612e-08 NA NA NA hsa-miR-374a-5p GSK3B 0.239597788731458 0.0202963000797544 0.265875974150976 0.000454893180511198 mirMAP -0.103740072088214 0.0257452070502647 NA NA NA hsa-miR-374b-5p GSK3B 0.00249900187478502 0.985380083859555 0.265875974150976 0.000454893180511198 mirMAP -0.171807057871124 4.56335978277982e-07 NA NA NA hsa-miR-16-5p H6PD 0.468459442059375 0.02635007201346 0.259516322986162 0.0394780541413495 mirMAP -0.162282785330627 6.88578333649196e-06 NA NA NA hsa-miR-16-5p HACE1 0.468459442059375 0.02635007201346 -0.0722952660501157 0.552389112912003 miRNAWalker2_validate -0.19519675084236 1.26965083152588e-08 NA NA NA hsa-miR-28-5p HDAC1 -0.22318016376076 0.0194144033008573 0.337671842225052 0.00235800809004367 miRanda -0.165594957961365 0.0262374073429614 NA NA NA hsa-miR-30a-5p HDAC1 -0.742755040631906 3.79943871404435e-05 0.337671842225052 0.00235800809004367 miRNAWalker2_validate -0.208940919407546 1.14959455020411e-08 NA NA NA hsa-miR-125b-2-3p HDAC2 -0.0327216991692278 0.904317305131546 0.418283864390938 3.1437336831761e-05 mirMAP -0.103494564450796 5.45171628918247e-06 NA NA NA hsa-miR-145-5p HDAC2 -1.54503595327403 2.65080161523141e-09 0.418283864390938 3.1437336831761e-05 miRNAWalker2_validate -0.107909285232772 2.26446940661105e-06 23499894 MiR 145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer; Ectopic expression of miRNA mimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells; In conclusion we suggest that loss or suppression of miR-145 may cause aberrant overexpression of HDAC2 and promote HCC tumorigenesis tumorigenesis liver cancer hsa-miR-195-3p HDAC2 -0.694544351365025 0.000214711021317786 0.418283864390938 3.1437336831761e-05 mirMAP -0.154158390056416 2.06244721566338e-06 NA NA NA hsa-miR-30a-3p HDAC2 -1.27950866170419 4.33230022379782e-09 0.418283864390938 3.1437336831761e-05 mirMAP -0.173688107714747 8.88550673979632e-11 NA NA NA hsa-miR-30a-5p HDAC2 -0.742755040631906 3.79943871404435e-05 0.418283864390938 3.1437336831761e-05 mirMAP -0.209750656356624 2.36995910574292e-10 NA NA NA hsa-miR-16-5p HECTD1 0.468459442059375 0.02635007201346 -0.106152421737443 0.264016507204639 miRNATAP -0.101369325132804 0.00019421821682059 NA NA NA hsa-miR-16-5p HELZ 0.468459442059375 0.02635007201346 0.176175036710462 0.0467006752430842 miRNAWalker2_validate;MirTarget;miRNATAP -0.103427876495712 4.414224355286e-05 NA NA NA hsa-miR-16-5p HHIPL1 0.468459442059375 0.02635007201346 0.317595615335507 0.136289877773182 mirMAP -0.295691278374031 1.20701357065279e-06 NA NA NA hsa-miR-16-5p HOXA3 0.468459442059375 0.02635007201346 0.0728298006718813 0.749239655839302 miRNAWalker2_validate;miRNATAP -0.563711414661623 4.64569841926458e-20 NA NA NA hsa-miR-16-5p HOXD1 0.468459442059375 0.02635007201346 -0.029373036593328 0.908678367896258 miRNATAP -0.183897957410029 0.0132692867407015 NA NA NA hsa-miR-16-5p HPCAL4 0.468459442059375 0.02635007201346 -3.30571688739834 1.29667683864775e-16 MirTarget -0.600553907426036 7.53484613838197e-07 NA NA NA hsa-miR-16-5p HPSE2 0.468459442059375 0.02635007201346 -3.51513084789656 1.06693416509876e-13 MirTarget -0.906966667668261 8.40633462064113e-11 NA NA NA hsa-miR-16-5p HSPA1A 0.468459442059375 0.02635007201346 -0.370346353218471 0.148021401695504 miRNAWalker2_validate -0.295135639859959 6.20674865181698e-05 NA NA NA hsa-miR-16-5p HSPA4L 0.468459442059375 0.02635007201346 -0.099897034975418 0.743997596825237 miRNAWalker2_validate;MirTarget -0.175422607049639 0.0485539860436279 NA NA NA hsa-miR-16-5p HSPG2 0.468459442059375 0.02635007201346 0.661442901032608 0.000453126923030142 MirTarget -0.315616033212308 4.54652310353776e-09 NA NA NA hsa-miR-16-5p HTR2A 0.468459442059375 0.02635007201346 -0.0710788448464774 0.841841357342253 MirTarget -0.74907282785162 2.82906380788781e-14 NA NA NA hsa-miR-16-5p HTRA1 0.468459442059375 0.02635007201346 0.213481585828939 0.258670710418387 miRNAWalker2_validate -0.260626346480076 1.35303091389739e-06 NA NA NA hsa-miR-16-5p IDS 0.468459442059375 0.02635007201346 -0.0995092469681822 0.452237040895841 miRNAWalker2_validate -0.313657379074617 2.27395060482473e-18 NA NA NA hsa-miR-16-5p IFT74 0.468459442059375 0.02635007201346 -0.242728882522678 0.0897650185438442 miRNAWalker2_validate;MirTarget -0.152826339983316 0.000207885325306881 NA NA NA hsa-miR-16-5p IGF1R 0.468459442059375 0.02635007201346 0.116961071763603 0.57112438908184 miRNATAP -0.294886587581129 5.30338289297577e-07 23507142 Furthermore we confirmed that IGF1R is a direct target of miR-16; In clinical specimens IGF1R levels inversely correlate with miR-16 expression; Our results provide significant clues regarding the role of miR-16 as a tumor suppressor by targeting IGF1R in OS sarcoma hsa-miR-16-5p IGSF1 0.468459442059375 0.02635007201346 -1.56519148367387 0.00072224183946043 miRNAWalker2_validate -0.671683974078191 4.73865862847679e-07 NA NA NA hsa-miR-16-5p IGSF9B 0.468459442059375 0.02635007201346 0.239398049711897 0.455821977868752 mirMAP -0.600778460398257 2.30942826429707e-11 NA NA NA hsa-miR-16-5p IKZF4 0.468459442059375 0.02635007201346 0.120876190425539 0.27264974134199 miRNAWalker2_validate -0.212180792922015 4.16292033197111e-12 NA NA NA hsa-miR-16-5p ILDR2 0.468459442059375 0.02635007201346 1.16237294137083 0.00026098079531004 MirTarget -0.500413354598693 4.44438330790511e-08 NA NA NA hsa-miR-16-5p INSR 0.468459442059375 0.02635007201346 0.318597619732127 0.00888759738704957 miRNATAP -0.132412543732975 0.000164501860539401 NA NA NA hsa-miR-16-5p IPO7 0.468459442059375 0.02635007201346 0.357155727271068 0.00106813004083192 miRNAWalker2_validate;MirTarget;miRNATAP -0.174464901967249 1.96133801631592e-08 NA NA NA hsa-miR-16-5p IRF2BPL 0.468459442059375 0.02635007201346 -0.347058176218165 0.0033304436134852 MirTarget;miRNATAP -0.199035713214705 2.81439486748525e-09 NA NA NA hsa-miR-16-5p IRS4 0.468459442059375 0.02635007201346 -2.36249743886607 2.07501297504123e-05 miRNAWalker2_validate -0.506285078891545 0.00193440388122074 NA NA NA hsa-miR-16-5p ISLR 0.468459442059375 0.02635007201346 0.5321687918509 0.0784934792224033 MirTarget;miRNATAP -0.580106747262188 7.41558860079758e-12 NA NA NA hsa-miR-16-5p ITGA10 0.468459442059375 0.02635007201346 -0.246637441238828 0.206017591376249 MirTarget -0.415722898275786 1.15496956633378e-14 NA NA NA hsa-miR-16-5p ITPR1 0.468459442059375 0.02635007201346 -0.978205239289609 1.76770291502282e-06 MirTarget;miRNATAP -0.426035149856977 1.98295555494393e-13 NA NA NA hsa-miR-16-5p JUN 0.468459442059375 0.02635007201346 -0.932062991848233 5.08561574713346e-09 miRNAWalker2_validate -0.25231147076691 6.33617418839725e-08 NA NA NA hsa-miR-16-5p KALRN 0.468459442059375 0.02635007201346 -0.81945095030466 1.13835675548545e-05 miRNATAP -0.232250653621005 1.99983909509575e-05 NA NA NA hsa-miR-16-5p KATNAL1 0.468459442059375 0.02635007201346 -0.238121876187191 0.227473164378047 miRNAWalker2_validate;MirTarget -0.576834242990971 2.45434054300305e-29 NA NA NA hsa-miR-16-5p KCNA6 0.468459442059375 0.02635007201346 -1.53132401304961 0.000130733110947696 MirTarget -0.71607705352043 3.55441918962027e-10 NA NA NA hsa-miR-16-5p KCNAB1 0.468459442059375 0.02635007201346 -0.754968741669846 1.71183749506925e-05 MirTarget;miRNATAP -0.40771787344237 6.31043670758783e-17 NA NA NA hsa-miR-16-5p KCND3 0.468459442059375 0.02635007201346 -1.25081349685282 8.58949377013892e-05 miRNAWalker2_validate -0.520563234771297 1.25600605292301e-08 NA NA NA hsa-miR-16-5p KCNG3 0.468459442059375 0.02635007201346 1.34395433211512 0.00292915672273903 miRNAWalker2_validate -0.485467764365733 0.000216668342201846 NA NA NA hsa-miR-16-5p KCNIP1 0.468459442059375 0.02635007201346 -0.519411010060551 0.200003568379995 MirTarget -0.779934711865576 5.90355764461817e-12 NA NA NA hsa-miR-16-5p KCNJ5 0.468459442059375 0.02635007201346 -0.280638251899976 0.333902387273937 mirMAP -0.223988166396357 0.00783950693720133 NA NA NA hsa-miR-16-5p KCNK3 0.468459442059375 0.02635007201346 -2.64642442933474 6.10994924328681e-09 mirMAP -1.10324495193175 6.67859561321954e-18 NA NA NA hsa-miR-16-5p KCNQ5 0.468459442059375 0.02635007201346 -2.00119079597222 6.28495431412454e-08 miRNATAP -0.679646886581465 1.97103627716931e-10 NA NA NA hsa-miR-16-5p KCNS2 0.468459442059375 0.02635007201346 -1.13465059933003 0.00300428795437821 miRNAWalker2_validate -0.266840931865886 0.0171216284325409 NA NA NA hsa-miR-16-5p KCTD8 0.468459442059375 0.02635007201346 -3.35886720251249 5.7801142054181e-10 miRNATAP -1.20221835702838 8.97490683184298e-15 NA NA NA hsa-miR-16-5p KDSR 0.468459442059375 0.02635007201346 0.239472778487095 0.0221636390920047 miRNAWalker2_validate;miRNATAP -0.152450046499612 3.05033832050861e-07 NA NA NA hsa-miR-16-5p KIAA0513 0.468459442059375 0.02635007201346 -0.784927887721409 7.70902360744078e-06 mirMAP -0.25023357301926 8.90429237715627e-07 NA NA NA hsa-miR-16-5p KIAA1614 0.468459442059375 0.02635007201346 -0.672817277076573 0.000878485556645909 mirMAP -0.506873064957155 3.45265899634808e-20 NA NA NA hsa-miR-16-5p KIAA1644 0.468459442059375 0.02635007201346 -1.36705906491291 0.000314678328832303 mirMAP -0.982679788998926 1.49526021456793e-21 NA NA NA hsa-miR-16-5p KIAA2022 0.468459442059375 0.02635007201346 -2.80598433621504 1.14813298037395e-09 MirTarget;miRNATAP -1.21400755920785 2.80818507031927e-21 NA NA NA hsa-miR-16-5p KIDINS220 0.468459442059375 0.02635007201346 -0.00131844135927928 0.988667768580193 miRNAWalker2_validate -0.217711391772549 3.67213196440608e-18 NA NA NA hsa-miR-16-5p KIF1B 0.468459442059375 0.02635007201346 -0.118034064564058 0.322584301029128 miRNAWalker2_validate;miRNATAP -0.243990933623704 1.3488633205512e-13 NA NA NA hsa-miR-16-5p KIF5A 0.468459442059375 0.02635007201346 -1.17412567940313 0.000901231572332803 miRNAWalker2_validate;MirTarget;miRNATAP -0.865700848787583 3.89765198818372e-19 NA NA NA hsa-miR-16-5p KIF5B 0.468459442059375 0.02635007201346 0.362139773365226 0.000658119616719543 miRNAWalker2_validate;miRNATAP -0.157872177721069 2.07586195887078e-07 NA NA NA hsa-miR-16-5p KIF5C 0.468459442059375 0.02635007201346 -0.770271099699533 0.00199021863152459 MirTarget;miRNATAP -0.33928946276061 2.28955568054353e-06 NA NA NA hsa-miR-16-5p KIRREL 0.468459442059375 0.02635007201346 0.573166115265245 0.00487177562588392 mirMAP -0.340796117799119 3.88069691869717e-09 NA NA NA hsa-miR-16-5p KLHDC8B 0.468459442059375 0.02635007201346 -0.829214497649129 1.56042718520463e-06 MirTarget -0.343981642976743 2.40576774744741e-12 NA NA NA hsa-miR-16-5p KLHL15 0.468459442059375 0.02635007201346 -0.362737945993933 0.012962856301377 miRNATAP -0.271029799208333 3.8988462149202e-11 NA NA NA hsa-miR-16-5p KLHL2 0.468459442059375 0.02635007201346 -0.0642115347207799 0.550174102630369 miRNATAP -0.129591870518469 2.39015858023852e-05 NA NA NA hsa-miR-16-5p KLHL21 0.468459442059375 0.02635007201346 -0.0975845665313919 0.477450242980798 mirMAP -0.269917095190094 1.48054758756288e-12 NA NA NA hsa-miR-16-5p KPNA3 0.468459442059375 0.02635007201346 0.252104157916224 0.00901567663252874 miRNAWalker2_validate;miRNATAP -0.103984074315861 0.000182093521915884 NA NA NA hsa-miR-16-5p KPNA4 0.468459442059375 0.02635007201346 0.138060971190837 0.137094124998354 miRNATAP -0.177392168920165 5.9025359220201e-12 NA NA NA hsa-miR-16-5p KPNA6 0.468459442059375 0.02635007201346 0.116490780512301 0.10622437759634 mirMAP;miRNATAP -0.106353286318521 1.57933970238701e-07 NA NA NA hsa-miR-16-5p KY 0.468459442059375 0.02635007201346 -2.68721369383042 5.09858933207314e-11 MirTarget -0.952949552316603 3.46723406078986e-16 NA NA NA hsa-miR-16-5p L1CAM 0.468459442059375 0.02635007201346 -1.36992600914329 0.00305982026557787 miRNAWalker2_validate -0.936167139589441 5.17382745400697e-13 NA NA NA hsa-miR-16-5p LAMB1 0.468459442059375 0.02635007201346 0.781376511163481 3.99206690301919e-08 miRNAWalker2_validate -0.153100626455691 0.000273029400359765 NA NA NA hsa-miR-16-5p LAMC1 0.468459442059375 0.02635007201346 0.370285667657678 0.0366283240859651 miRNAWalker2_validate;MirTarget -0.34568030515619 2.92954987151097e-12 NA NA NA hsa-miR-16-5p LATS1 0.468459442059375 0.02635007201346 0.108677825624674 0.342084497365957 miRNAWalker2_validate;MirTarget;miRNATAP -0.155149099877995 1.86199531577411e-06 NA NA NA hsa-miR-16-5p LATS2 0.468459442059375 0.02635007201346 0.159417049044428 0.23040279833664 miRNATAP -0.323008139810548 2.35421366209395e-19 NA NA NA hsa-miR-16-5p LDLRAD2 0.468459442059375 0.02635007201346 0.569786824502446 0.000691379024921154 MirTarget -0.238511013428141 7.97697097767497e-07 NA NA NA hsa-miR-16-5p LDOC1L 0.468459442059375 0.02635007201346 -0.0790407162093647 0.481748910951884 mirMAP -0.113270919050502 0.000445566803306658 NA NA NA hsa-miR-16-5p LIG4 0.468459442059375 0.02635007201346 -0.0223675428716588 0.846578792718768 miRNAWalker2_validate -0.119230287270605 0.000324599503081908 NA NA NA hsa-miR-16-5p LIN7C 0.468459442059375 0.02635007201346 0.24175305422481 0.0265810890372601 miRNAWalker2_validate -0.139441530297821 7.81433863146203e-06 NA NA NA hsa-miR-16-5p LMX1B 0.468459442059375 0.02635007201346 0.29797438250427 0.580935368573424 mirMAP -0.319177184183924 0.0420641365000263 NA NA NA hsa-miR-16-5p LONRF2 0.468459442059375 0.02635007201346 -2.03899615797417 9.63293546267136e-06 miRNAWalker2_validate;mirMAP -1.12374527770003 1.17310427361064e-18 NA NA NA hsa-miR-16-5p LPP 0.468459442059375 0.02635007201346 -0.458891651324375 0.0447471835132921 mirMAP;miRNATAP -0.796205529944824 3.81239052718375e-46 NA NA NA hsa-miR-16-5p LRIG1 0.468459442059375 0.02635007201346 -0.5374742879248 0.00587721628379153 MirTarget -0.375383643444201 7.45754189277738e-12 NA NA NA hsa-miR-16-5p LRIG2 0.468459442059375 0.02635007201346 0.233646121703766 0.020894431221445 MirTarget -0.125173660911016 1.54624163044483e-05 NA NA NA hsa-miR-16-5p LRP1B 0.468459442059375 0.02635007201346 -2.16345659630435 6.96966627503369e-08 MirTarget;miRNATAP -0.928916768239105 2.02133930764754e-16 NA NA NA hsa-miR-16-5p LRP6 0.468459442059375 0.02635007201346 0.526407698113248 1.3788363910036e-05 miRNATAP -0.110493252843006 0.00185180406854409 NA NA NA hsa-miR-16-5p LRRC58 0.468459442059375 0.02635007201346 0.66871614549604 1.31610828919559e-10 miRNATAP -0.119278606802942 0.000116264518628475 NA NA NA hsa-miR-16-5p LRRC7 0.468459442059375 0.02635007201346 -1.34133723141535 0.0119253573751723 MirTarget -1.36620338715309 2.63867324517941e-21 NA NA NA hsa-miR-16-5p LRRC8C 0.468459442059375 0.02635007201346 0.211614278241733 0.126207579285338 MirTarget -0.112548199391242 0.00494434337829752 NA NA NA hsa-miR-16-5p LRRN3 0.468459442059375 0.02635007201346 -0.39264287572501 0.162925453177655 MirTarget;miRNATAP -0.449253733110381 1.82456508380679e-08 NA NA NA hsa-miR-16-5p LSM11 0.468459442059375 0.02635007201346 0.273916573216644 0.0292937409084412 MirTarget -0.22903720839219 8.37969991727e-11 NA NA NA hsa-miR-16-5p LURAP1L 0.468459442059375 0.02635007201346 0.456363320793577 0.0193737261905497 MirTarget -0.195186730887635 0.000555462549798469 NA NA NA hsa-miR-16-5p LUZP1 0.468459442059375 0.02635007201346 0.0204348350345764 0.850767351504186 miRNAWalker2_validate;MirTarget;miRNATAP -0.1007771537632 0.00124380121286443 NA NA NA hsa-miR-16-5p LYPLAL1 0.468459442059375 0.02635007201346 -0.157177158574202 0.196866811618413 MirTarget -0.124297200442016 0.000387251260067252 NA NA NA hsa-miR-16-5p MACF1 0.468459442059375 0.02635007201346 0.0187245853067326 0.903346275968091 miRNAWalker2_validate -0.382566258295924 2.93572233474812e-20 NA NA NA hsa-miR-139-5p MAD2L1 -1.41674256628297 4.51005988644234e-14 1.63966217908557 9.51989770519487e-16 miRanda -0.519577824381155 3.45963417462254e-16 NA NA NA hsa-miR-28-5p MAD2L1 -0.22318016376076 0.0194144033008573 1.63966217908557 9.51989770519487e-16 miRanda -0.661794815002674 3.3995286469532e-06 NA NA NA hsa-miR-16-5p MAFG 0.468459442059375 0.02635007201346 0.222547086064494 0.028030617181556 mirMAP -0.126200824556993 1.33620512633729e-05 NA NA NA hsa-miR-16-5p MAMSTR 0.468459442059375 0.02635007201346 -0.262072467781216 0.163325180352557 MirTarget;miRNATAP -0.246278319678877 4.72047360206753e-06 NA NA NA hsa-miR-16-5p MAP3K3 0.468459442059375 0.02635007201346 -0.290635931768054 0.0156524405164107 MirTarget;miRNATAP -0.243028170347395 3.64755013326269e-13 NA NA NA hsa-miR-16-5p MAP4 0.468459442059375 0.02635007201346 -0.163588092539192 0.111437492900646 miRNAWalker2_validate -0.209564074200104 1.57041941365428e-13 NA NA NA hsa-miR-16-5p MASP1 0.468459442059375 0.02635007201346 -2.34760889536794 1.59773340164496e-10 MirTarget -0.606164314674776 2.01602511796994e-08 NA NA NA hsa-miR-16-5p MBNL2 0.468459442059375 0.02635007201346 -0.199715343562235 0.128021493866242 MirTarget -0.290990291333595 6.06618708169959e-16 NA NA NA hsa-miR-139-5p MCM2 -1.41674256628297 4.51005988644234e-14 1.4795750564852 6.34536420487899e-16 miRanda -0.512822498855157 8.41046223637005e-20 NA NA NA hsa-miR-129-5p MCM4 -1.61803714443871 4.93214379865694e-06 1.44615845886958 3.18080640233148e-15 miRanda -0.136153076359218 3.9065249875418e-05 NA NA NA hsa-miR-23b-3p MCM4 -0.228571473429 0.0553601132069074 1.44615845886958 3.18080640233148e-15 MirTarget -0.317799394561249 0.00175550038833842 NA NA NA hsa-miR-28-5p MCM5 -0.22318016376076 0.0194144033008573 0.751988942553129 5.73611778936776e-08 miRanda -0.240822071166661 0.0110874634128438 NA NA NA hsa-miR-30c-2-3p MCM6 -0.850499600024184 1.80492410494116e-05 0.82730185832792 9.8266323424003e-11 MirTarget -0.316452054783559 1.03877771261775e-16 NA NA NA hsa-miR-140-5p MDM2 0.132398579631585 0.457960134430787 0.684922426263625 2.25604330928728e-05 miRanda -0.118928275348611 0.0363891795263222 NA NA NA hsa-miR-143-3p MDM2 -0.941264957317006 7.19918948927784e-06 0.684922426263625 2.25604330928728e-05 miRNAWalker2_validate -0.180383156186656 0.000115815216754902 NA NA NA hsa-miR-145-5p MDM2 -1.54503595327403 2.65080161523141e-09 0.684922426263625 2.25604330928728e-05 miRNAWalker2_validate -0.198874217191523 5.71192946278001e-08 NA NA NA hsa-miR-181a-2-3p MDM2 0.761758815767271 3.4163207928657e-06 0.684922426263625 2.25604330928728e-05 mirMAP -0.12351540646709 0.0420557321490906 NA NA NA hsa-miR-23b-3p MDM2 -0.228571473429 0.0553601132069074 0.684922426263625 2.25604330928728e-05 mirMAP -0.19056537785509 0.0271564148046807 NA NA NA hsa-miR-26b-5p MDM2 -0.499493687076043 0.0118149973400486 0.684922426263625 2.25604330928728e-05 miRNAWalker2_validate -0.109564644928444 0.0305745771657186 NA NA NA hsa-miR-374b-5p MDM2 0.00249900187478502 0.985380083859555 0.684922426263625 2.25604330928728e-05 mirMAP -0.269149244343905 0.000306005928313723 NA NA NA hsa-miR-16-5p MDM4 0.468459442059375 0.02635007201346 0.345358152785799 0.00761701135215303 mirMAP -0.197164040350921 8.9490623845823e-08 NA NA NA hsa-miR-16-5p MEGF8 0.468459442059375 0.02635007201346 -0.00501465406510615 0.971290876783669 miRNAWalker2_validate -0.141768874070479 0.00040144463024231 NA NA NA hsa-miR-16-5p MEOX2 0.468459442059375 0.02635007201346 -0.305974715077866 0.450206805337241 MirTarget -0.905672280661752 3.91280095435918e-16 NA NA NA hsa-miR-16-5p MERTK 0.468459442059375 0.02635007201346 -0.375050627963859 0.0156091204089872 miRNAWalker2_validate -0.151421449728791 0.000749619054388403 NA NA NA hsa-miR-16-5p MEX3B 0.468459442059375 0.02635007201346 0.725871921297744 2.11635015696509e-05 mirMAP -0.181532359617913 0.000278683844453647 NA NA NA hsa-miR-16-5p MFAP5 0.468459442059375 0.02635007201346 -1.38773655702249 0.000288777288845266 MirTarget -0.718974596134424 3.50862886378419e-11 NA NA NA hsa-miR-16-5p MFN2 0.468459442059375 0.02635007201346 -0.647864677799688 2.8742769870846e-10 miRNAWalker2_validate;MirTarget -0.115472419116993 0.000154835644431568 NA NA NA hsa-miR-16-5p MIB1 0.468459442059375 0.02635007201346 0.377930072259812 0.0014356013263503 miRNAWalker2_validate;miRNATAP -0.172105762637889 3.97832502389678e-07 NA NA NA hsa-miR-16-5p MICALL1 0.468459442059375 0.02635007201346 -1.07593882194617 4.8125987786878e-15 mirMAP -0.179390964165711 1.59936941240217e-05 NA NA NA hsa-miR-16-5p MINA 0.468459442059375 0.02635007201346 -0.0188006790392334 0.853825914775513 miRNAWalker2_validate -0.15521536489991 7.01057242507052e-08 NA NA NA hsa-miR-16-5p MIPOL1 0.468459442059375 0.02635007201346 -0.447829692526657 0.0518176143675605 MirTarget -0.306088001248239 3.56916648755153e-06 NA NA NA hsa-miR-16-5p MKL2 0.468459442059375 0.02635007201346 -0.0606062035513188 0.556642646863117 mirMAP -0.214991688547239 3.33117801274413e-14 NA NA NA hsa-miR-16-5p MKX 0.468459442059375 0.02635007201346 -0.435370995520897 0.251965832901685 MirTarget -1.02933078632379 1.95893870636024e-24 NA NA NA hsa-miR-16-5p MLLT11 0.468459442059375 0.02635007201346 -0.661499646297612 0.0173342419671774 miRNAWalker2_validate -0.55520039929566 9.13651104251797e-13 NA NA NA hsa-miR-16-5p MLXIP 0.468459442059375 0.02635007201346 0.160252052914747 0.247608838546493 mirMAP -0.159345384262891 6.1403879251598e-05 NA NA NA hsa-miR-16-5p MLYCD 0.468459442059375 0.02635007201346 -0.854008710760923 8.99149875365599e-11 MirTarget -0.125637518375925 0.00145627140057683 NA NA NA hsa-miR-16-5p MMD 0.468459442059375 0.02635007201346 0.358596402380194 0.0168656186141133 miRNATAP -0.230934052855818 6.46319342433511e-08 NA NA NA hsa-miR-16-5p MORF4L1 0.468459442059375 0.02635007201346 -0.050308393481524 0.532285102555087 miRNAWalker2_validate -0.10283256902362 6.64486930396549e-06 NA NA NA hsa-miR-16-5p MRAS 0.468459442059375 0.02635007201346 -0.140957991947981 0.473453737783408 miRNATAP -0.42374282985915 5.06025593284345e-15 NA NA NA hsa-miR-16-5p MRC2 0.468459442059375 0.02635007201346 0.317111233799408 0.110374875803994 miRNAWalker2_validate -0.303052042136849 8.05753098368036e-08 NA NA NA hsa-miR-16-5p MTSS1 0.468459442059375 0.02635007201346 -0.810088738785264 0.000353714566592768 miRNATAP -0.242236950988633 0.000246336533270653 NA NA NA hsa-miR-16-5p MTSS1L 0.468459442059375 0.02635007201346 -0.0650296407852853 0.747126264282662 mirMAP -0.380370991245977 1.45342651275262e-11 NA NA NA hsa-miR-16-5p MYBL1 0.468459442059375 0.02635007201346 0.493754443604026 0.0215216223713438 miRNATAP -0.181248792407577 0.00369626426542388 NA NA NA hsa-let-7c-5p MYC -0.148489254129201 0.548077841857242 -0.025616667114428 0.889168572840311 miRNAWalker2_validate;miRTarBase -0.117429030238432 0.00982219946674066 22128178 MicroRNA let 7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells prostate cancer hsa-miR-26a-5p MYC -0.507487084157331 3.23715933371269e-05 -0.025616667114428 0.889168572840311 miRNAWalker2_validate -0.282916794526639 0.00222606342624675 21901171 Our results identify new molecular targets of c-Myc in AML and highlight miR-26a attractiveness as a therapeutic target in leukemia acute myeloid leukemia hsa-miR-34c-5p MYC 1.37406314990472 2.42956736488761e-09 -0.025616667114428 0.889168572840311 miRNAWalker2_validate;miRTarBase;miRanda -0.161936986237348 0.000782914009115942 NA NA NA hsa-miR-16-5p MYLK 0.468459442059375 0.02635007201346 -1.44806395967964 9.65012105905573e-05 MirTarget;miRNATAP -1.21827756361636 6.93194595929753e-38 NA NA NA hsa-miR-16-5p MYLK4 0.468459442059375 0.02635007201346 0.333416398515097 0.102749467602 MirTarget -0.233793510175809 7.06274802590695e-05 NA NA NA hsa-miR-16-5p MYO5A 0.468459442059375 0.02635007201346 -0.085562862894208 0.616615957919168 miRNAWalker2_validate;MirTarget -0.247950594795684 3.33122759118499e-07 NA NA NA hsa-miR-16-5p MYRIP 0.468459442059375 0.02635007201346 -2.5374866261714 8.43578141822633e-10 MirTarget -0.627292847610147 2.67882599295866e-07 NA NA NA hsa-miR-16-5p NAPG 0.468459442059375 0.02635007201346 -0.0344836750791524 0.746418121504312 miRNAWalker2_validate;MirTarget -0.127532147241261 2.78577248792383e-05 NA NA NA hsa-miR-16-5p NAV1 0.468459442059375 0.02635007201346 0.477474295721475 0.00162695645144269 MirTarget;miRNATAP -0.188279364690914 1.68217487893345e-05 NA NA NA hsa-miR-16-5p NAV2 0.468459442059375 0.02635007201346 -0.121843329970551 0.549053973627072 miRNAWalker2_validate -0.454131857946469 3.70288888680419e-16 NA NA NA hsa-miR-16-5p NCKAP5L 0.468459442059375 0.02635007201346 0.322011859255949 0.0204832533388973 miRNAWalker2_validate -0.146761907406723 0.000254004434309034 NA NA NA hsa-miR-16-5p NCS1 0.468459442059375 0.02635007201346 -0.652620477793938 0.0278454371426777 MirTarget;miRNATAP -0.762044031720421 1.56522891097031e-21 NA NA NA hsa-miR-16-5p NDST1 0.468459442059375 0.02635007201346 -0.130588786602125 0.314387734671676 mirMAP -0.14455568247107 0.000103793774758651 NA NA NA hsa-miR-16-5p NEMF 0.468459442059375 0.02635007201346 0.150035974961459 0.138103016801428 miRNAWalker2_validate -0.15507528536975 5.84847005853047e-08 NA NA NA hsa-miR-16-5p NFASC 0.468459442059375 0.02635007201346 -1.21285969875073 0.000588897114251105 MirTarget;mirMAP -0.923025171149299 4.38768037522679e-22 21081469 NF κB targets miR 16 and miR 21 in gastric cancer: involvement of prostaglandin E receptors gastric cancer hsa-miR-16-5p NFAT5 0.468459442059375 0.02635007201346 0.461239695424155 0.000656069696676909 MirTarget -0.271054050062119 9.17697579506393e-13 NA NA NA hsa-miR-16-5p NIN 0.468459442059375 0.02635007201346 -0.252681320029704 0.137941934206193 miRNAWalker2_validate -0.27170905073939 1.791341734522e-08 NA NA NA hsa-miR-16-5p NISCH 0.468459442059375 0.02635007201346 -0.213906871340342 0.0375209797915912 miRNAWalker2_validate;MirTarget -0.195189424772162 9.94895953589447e-12 NA NA NA hsa-miR-16-5p NLGN1 0.468459442059375 0.02635007201346 -2.68234371159062 4.2506090500709e-08 miRNATAP -1.18542248163708 5.26967902480931e-18 NA NA NA hsa-miR-16-5p NOS1 0.468459442059375 0.02635007201346 -2.96330117656761 1.10501685397827e-08 miRNATAP -1.53566922759355 4.31480263010233e-28 NA NA NA hsa-miR-16-5p NOTCH2 0.468459442059375 0.02635007201346 0.138226358603258 0.351625722215957 miRNAWalker2_validate;MirTarget -0.25803041862607 6.08848169007449e-10 NA NA NA hsa-miR-16-5p NPR3 0.468459442059375 0.02635007201346 -1.50737055199652 6.49105069424171e-05 miRNAWalker2_validate -0.877956746326212 5.13448450596525e-17 NA NA NA hsa-miR-16-5p NR2C2 0.468459442059375 0.02635007201346 0.210165761701234 0.0322359853207322 MirTarget -0.184161521301135 1.74423201243664e-11 NA NA NA hsa-miR-16-5p NRP1 0.468459442059375 0.02635007201346 0.575916847809068 0.000209823999859742 miRNAWalker2_validate -0.16839528476308 0.000196487305770999 NA NA NA hsa-miR-16-5p NRXN1 0.468459442059375 0.02635007201346 -3.77804960296992 8.78046893071678e-12 miRNAWalker2_validate -1.39938009409184 4.29240071489581e-19 NA NA NA hsa-miR-16-5p NTN1 0.468459442059375 0.02635007201346 -2.06447596754744 1.49348953834274e-09 mirMAP -0.949150266274954 4.79582430826333e-24 NA NA NA hsa-miR-16-5p NUAK1 0.468459442059375 0.02635007201346 0.903691548095403 1.06789665825318e-08 MirTarget -0.201242797582886 1.57782975535527e-05 NA NA NA hsa-miR-16-5p NUCKS1 0.468459442059375 0.02635007201346 0.325102076142334 0.00397222584600734 MirTarget;miRNATAP -0.147282996492871 5.44529489687387e-06 NA NA NA hsa-miR-16-5p NYNRIN 0.468459442059375 0.02635007201346 -0.630390629178288 0.00200658592231293 miRNATAP -0.303599530476524 2.12103059526743e-07 NA NA NA hsa-miR-16-5p OCRL 0.468459442059375 0.02635007201346 -0.0947309485303247 0.387392454978538 miRNATAP -0.212830381149064 2.55921665658822e-12 NA NA NA hsa-miR-16-5p OTUD3 0.468459442059375 0.02635007201346 0.435976725971797 0.00592113449804049 mirMAP -0.168170989559226 0.000246053161002335 NA NA NA hsa-miR-16-5p OTUD7B 0.468459442059375 0.02635007201346 0.125414398965607 0.159181493421655 miRNAWalker2_validate -0.142037675788495 1.43652449616841e-08 NA NA NA hsa-miR-16-5p PACSIN3 0.468459442059375 0.02635007201346 -0.27334408792554 0.250309873234724 miRNAWalker2_validate -0.263485512762788 0.000118738990845657 NA NA NA hsa-miR-16-5p PAFAH1B1 0.468459442059375 0.02635007201346 -0.429125161604443 1.79547396100101e-08 MirTarget;miRNATAP -0.133570353456231 1.02116440363659e-09 NA NA NA hsa-miR-16-5p PAM 0.468459442059375 0.02635007201346 -0.213715233670169 0.151419217579645 miRNATAP -0.396050410355992 1.58632350083163e-23 NA NA NA hsa-miR-16-5p PAPOLG 0.468459442059375 0.02635007201346 0.193729750745415 0.0111585726387438 miRNAWalker2_validate -0.111937839851531 2.18839531000593e-07 NA NA NA hsa-miR-16-5p PAPPA 0.468459442059375 0.02635007201346 -0.147868440566481 0.520876658558301 MirTarget;miRNATAP -0.225448753787712 0.000693353851735643 NA NA NA hsa-miR-16-5p PAQR3 0.468459442059375 0.02635007201346 -0.194298250668846 0.0935144781853434 miRNAWalker2_validate -0.184600607367071 1.7196259469888e-08 NA NA NA hsa-miR-16-5p PARVA 0.468459442059375 0.02635007201346 -0.476179816551364 0.00428675171134699 MirTarget -0.531320650956736 6.43849000894196e-36 NA NA NA hsa-miR-16-5p PBX3 0.468459442059375 0.02635007201346 -0.281102097769818 0.131536814716469 miRNATAP -0.50420802482966 2.12473951769443e-24 NA NA NA hsa-miR-16-5p PCDH17 0.468459442059375 0.02635007201346 0.730714992703952 1.70412772811198e-05 MirTarget;miRNATAP -0.194510694021036 8.89992282496763e-05 NA NA NA hsa-miR-16-5p PCDH9 0.468459442059375 0.02635007201346 -1.82279707707595 3.76874897040946e-05 MirTarget;miRNATAP -1.14209247123766 3.14895924735193e-21 NA NA NA hsa-miR-16-5p PCDHAC2 0.468459442059375 0.02635007201346 -0.527421449979268 0.137809971002795 MirTarget -0.565887087843295 2.04071091436926e-08 NA NA NA hsa-miR-30a-5p PCNA -0.742755040631906 3.79943871404435e-05 1.11506935052714 4.38860796593519e-11 miRNAWalker2_validate -0.446281156343994 1.95417138286695e-15 NA NA NA hsa-miR-16-5p PDE3B 0.468459442059375 0.02635007201346 0.366558093816732 0.0946773467248489 miRNAWalker2_validate;MirTarget -0.216845815468813 0.00062708324934599 NA NA NA hsa-miR-16-5p PDE4D 0.468459442059375 0.02635007201346 -0.501529812759653 0.00928430510499284 miRNAWalker2_validate -0.374776175816633 4.11118803599634e-12 NA NA NA hsa-miR-16-5p PDK4 0.468459442059375 0.02635007201346 -2.72064215500525 3.77755401072187e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.922764062716761 2.07153485834751e-16 NA NA NA hsa-miR-16-5p PDLIM5 0.468459442059375 0.02635007201346 -0.168385398461586 0.0796869456329142 miRNAWalker2_validate;miRNATAP -0.189232413443999 1.19299814306157e-12 NA NA NA hsa-miR-16-5p PDPR 0.468459442059375 0.02635007201346 0.163813448707733 0.242671572026521 miRNAWalker2_validate;miRNATAP -0.18777499217832 2.67867804266998e-06 NA NA NA hsa-miR-16-5p PELI2 0.468459442059375 0.02635007201346 -0.532094100359477 0.0135757742377333 miRNATAP -0.139911651025429 0.0261642985828878 NA NA NA hsa-miR-16-5p PELO 0.468459442059375 0.02635007201346 -0.183088204256144 0.0456129051147005 miRNAWalker2_validate -0.136173030617048 1.51434673450828e-07 NA NA NA hsa-miR-16-5p PHACTR2 0.468459442059375 0.02635007201346 -0.115245439006029 0.310465738797971 miRNATAP -0.222525032192817 1.66550353144373e-12 NA NA NA hsa-miR-16-5p PHC3 0.468459442059375 0.02635007201346 0.211887804282655 0.0498991979774048 miRNAWalker2_validate;MirTarget -0.195374952824763 1.08054352354553e-10 NA NA NA hsa-miR-16-5p PHF21A 0.468459442059375 0.02635007201346 -0.314340471617779 0.00621059979506441 MirTarget -0.260185824054466 1.56894935698763e-16 NA NA NA hsa-miR-16-5p PHIP 0.468459442059375 0.02635007201346 0.423267798572117 0.000305386538851739 miRNAWalker2_validate -0.147281969318514 1.36639919145173e-05 NA NA NA hsa-miR-16-5p PHKA1 0.468459442059375 0.02635007201346 -0.165201319159352 0.56191637873088 miRNAWalker2_validate -0.364000033545834 8.10717049614783e-06 NA NA NA hsa-miR-16-5p PHLDB2 0.468459442059375 0.02635007201346 -0.643125760304128 0.012847520867423 miRNAWalker2_validate -0.694262113436773 9.4621483171355e-24 NA NA NA hsa-miR-16-5p PIAS2 0.468459442059375 0.02635007201346 0.0999742411474212 0.410460583701402 MirTarget -0.122595935665893 0.000444587229355797 NA NA NA hsa-miR-16-5p PID1 0.468459442059375 0.02635007201346 -1.58515404529655 7.01847972866481e-08 MirTarget;miRNATAP -0.540141941294855 1.95870706468203e-10 NA NA NA hsa-miR-16-5p PIK3R1 0.468459442059375 0.02635007201346 -0.132584613334835 0.368540743016032 MirTarget -0.331876883174364 1.84458792077216e-16 NA NA NA hsa-miR-16-5p PIKFYVE 0.468459442059375 0.02635007201346 0.176813650074187 0.0954863222067187 MirTarget -0.113730469127719 0.000187517571828208 NA NA NA hsa-miR-16-5p PIM1 0.468459442059375 0.02635007201346 -1.11369789456653 7.42912371797285e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.18406204272965 0.000324895960142121 NA NA NA hsa-miR-16-5p PIP4K2B 0.468459442059375 0.02635007201346 0.176396912458267 0.06975976166235 miRNAWalker2_validate -0.117801372763649 2.26008185016932e-05 NA NA NA hsa-miR-16-5p PITPNM2 0.468459442059375 0.02635007201346 -0.467517560436463 0.00215939954517204 mirMAP -0.261987341814328 1.37656447618743e-09 NA NA NA hsa-miR-16-5p PITPNM3 0.468459442059375 0.02635007201346 -1.63914377631659 3.3142339868577e-07 MirTarget -0.680937041324097 7.89021186643839e-14 NA NA NA hsa-miR-16-5p PLEC 0.468459442059375 0.02635007201346 0.562959901812738 0.000191283292894481 miRNAWalker2_validate -0.116765430775774 0.00827354225527411 NA NA NA hsa-miR-16-5p PLEKHA1 0.468459442059375 0.02635007201346 0.13326283541206 0.23636502532347 MirTarget;miRNATAP -0.118684575126443 0.000238751001223287 NA NA NA hsa-miR-16-5p PLEKHA5 0.468459442059375 0.02635007201346 -0.0209985094569882 0.878336125773638 MirTarget -0.293982866819479 6.28745866141324e-15 NA NA NA hsa-miR-16-5p PLEKHM3 0.468459442059375 0.02635007201346 -0.264766226099178 0.0391508799138563 MirTarget -0.377664842640504 8.87253566966314e-30 NA NA NA hsa-miR-100-5p PLK1 -0.343735526262058 0.133995182819209 2.00336669374513 1.88589235947823e-17 miRNAWalker2_validate;miRTarBase -0.447551637343048 4.46474474744377e-12 23151088;22246341;23842624;25537513;22120675;21636267 MicroRNA 100 is a potential molecular marker of non small cell lung cancer and functions as a tumor suppressor by targeting polo like kinase 1; By using microRNA miR target prediction algorithms we identified miR-100 that might potentially bind the 3'-untranslated region of PLK1 transcripts; The purpose of this study was to investigate the roles of miR-100 and its association with PLK1 in NSCLC development; Finally the effects of miR-100 expression on growth apoptosis and cell cycle of NSCLC cells by posttranscriptionally regulating PLK1 expression were determined; Meanwhile miR-100 mimics could significantly inhibit PLK1 mRNA and protein expression and reduce the luciferase activity of a PLK1 3' untranslated region-based reporter construct in A549 cells; Furthermore small interfering RNA siRNA-mediated PLK1 downregulation could mimic the effects of miR-100 mimics while PLK1 overexpression could partially rescue the phenotypical changes of NSCLC cells induced by miR-100 mimics; Our findings indicate that low miR-100 may be a poor prognostic factor for NSCLC patients and functions as a tumor suppressor by posttranscriptionally regulating PLK1 expression;Together these results suggest that low miR-100 expression may be an independent poor prognostic factor and miR-100 can function as a tumor suppressor by targeting PLK1 in human EOCs;In HCC tissues miR-100 expression was inversely correlated with the expression of plk1 protein r = -0.418; P = 0.029; Therefore downregulation of miR-100 was correlated with progressive pathological feature and poor prognosis in HCC patients and miR-100 could function as a tumor suppressor by targeting plk1;Here we show that miR-100 inhibits maintenance and expansion of BrCSCs in basal-like cancer through Polo-like kinase1 Plk1 down-regulation;MiR 100 resensitizes docetaxel resistant human lung adenocarcinoma cells SPC A1 to docetaxel by targeting Plk1; Knock-down of Plk1 which was a direct target of miR-100 yielded similar effects as that of ectopic miR-100 expression; The inverse correlation between miR-100 and Plk1 expression was also detected in nude mice SPC-A1/DTX tumor xenografts and clinical lung adenocarcinoma tissues and was proved to be related with the in vivo response to docetaxel; Thus our results suggested that down-regulation of miR-100 could lead to Plk1 over-expression and eventually to docetaxel chemoresistance of human lung adenocarcinoma;Reduced miR 100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 protein; Through modulating miR-100 expression using miR-100 inhibitor or mimic in vitro cell growth cycle and apoptosis were tested separately by MTT or flow cytometry and meanwhile Polo-like kinase1 PLK1 mRNA and protein expressions were detected by qRT-PCR and immunoblotting; The expression of PLK1 in 125 cervical tissues was also examined by immunohistochemical staining and the correlation between miR-100 and PLK1 expression in the same tissues was analysed; The modulation of miR-100 expression remarkably influenced cell proliferation cycle and apoptosis as well as the level of PLK1 protein but not mRNA in vitro experiments; PLK1 expression was negatively correlated with miR-100 expression in CIN3 and cervical cancer tissues; The reduced miR-100 expression participates in the development of cervical cancer at least partly through loss of inhibition to target gene PLK1 which probably occurs in a relative late phase of carcinogenesis ;;progression;worse prognosis;;drug resistance;tumorigenesis lung squamous cell cancer;ovarian cancer;liver cancer;breast cancer;lung cancer;cervical and endocervical cancer hsa-miR-16-5p PLSCR4 0.468459442059375 0.02635007201346 -0.474237245058613 0.0383317279289207 miRNAWalker2_validate;MirTarget -0.656407825643764 8.88816740538975e-28 NA NA NA hsa-miR-16-5p PLXDC1 0.468459442059375 0.02635007201346 0.820266014829211 1.64486390939186e-07 mirMAP -0.207754578345269 6.03089285063548e-06 NA NA NA hsa-miR-16-5p PLXNA2 0.468459442059375 0.02635007201346 -0.394952139559956 0.00778505791950615 MirTarget;miRNATAP -0.108987714429131 0.0116859243717001 NA NA NA hsa-miR-16-5p PMP2 0.468459442059375 0.02635007201346 -3.58172675758482 1.88286205374656e-12 miRNATAP -1.35899577865752 2.03979545184531e-21 NA NA NA hsa-miR-16-5p PNISR 0.468459442059375 0.02635007201346 -0.0767243216354423 0.536610143649601 MirTarget;miRNATAP -0.176743645174074 5.33818147146534e-07 NA NA NA hsa-miR-16-5p PNMAL2 0.468459442059375 0.02635007201346 -0.388731784393724 0.0887590872423807 MirTarget -0.465078278679235 2.43404850231523e-13 NA NA NA hsa-miR-16-5p PPM1A 0.468459442059375 0.02635007201346 -0.623302585337666 5.30525296218818e-12 MirTarget;miRNATAP -0.206808354230169 9.99481554301912e-16 NA NA NA hsa-miR-16-5p PPM1E 0.468459442059375 0.02635007201346 0.150874141379553 0.574319966175631 MirTarget -0.219013045585152 0.00487073573765172 NA NA NA hsa-miR-16-5p PPM1K 0.468459442059375 0.02635007201346 -0.999161564755304 1.37921237142718e-08 MirTarget -0.370799461906485 1.55912735282222e-13 NA NA NA hsa-miR-16-5p PPM1L 0.468459442059375 0.02635007201346 -0.537351176754866 0.00615520293012723 MirTarget -0.366939668357723 3.08362601116875e-11 NA NA NA hsa-miR-16-5p PPP3CB 0.468459442059375 0.02635007201346 -0.422780562757183 4.51344710656914e-05 miRNATAP -0.238877122232723 7.04452900892349e-17 NA NA NA hsa-miR-16-5p PRKAB2 0.468459442059375 0.02635007201346 -0.367111274928678 0.0137111089812302 miRNAWalker2_validate;MirTarget -0.390410015091595 1.35560566353115e-22 NA NA NA hsa-miR-16-5p PRKAR1A 0.468459442059375 0.02635007201346 -0.0626576748573413 0.503137741080174 miRNAWalker2_validate -0.111196535891916 3.05520193030518e-05 NA NA NA hsa-miR-16-5p PRKAR2A 0.468459442059375 0.02635007201346 -0.0807414545032392 0.4668186025327 miRNAWalker2_validate -0.149311941864718 2.22104468677917e-06 NA NA NA hsa-miR-101-5p PRKDC -0.368786665738683 0.0435281632867238 1.13445196741108 9.79968848250475e-16 miRNAWalker2_validate;miRTarBase -0.255715296656963 2.33817744107365e-07 22014955 Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299 H1975 and A549 cells it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells lung squamous cell cancer hsa-miR-16-5p PRKG1 0.468459442059375 0.02635007201346 -0.561746760371328 0.0108057633457725 miRNATAP -0.723985791692614 5.73785213771841e-39 NA NA NA hsa-miR-16-5p PRNP 0.468459442059375 0.02635007201346 -0.769694673212605 6.60491278620587e-05 miRNAWalker2_validate -0.462107200752552 3.76796746513687e-18 NA NA NA hsa-miR-16-5p PRTG 0.468459442059375 0.02635007201346 -0.0504992287070438 0.858450200149841 MirTarget -0.666990125331125 4.84886015884394e-18 NA NA NA hsa-miR-16-5p PRX 0.468459442059375 0.02635007201346 -0.550672139541812 0.000773270264703616 mirMAP -0.306235900140905 3.61724734902388e-11 NA NA NA hsa-miR-16-5p PTCH1 0.468459442059375 0.02635007201346 -0.0998087706005091 0.617896719568664 miRNATAP -0.201743540787871 0.00046730003608423 NA NA NA hsa-miR-16-5p PTCHD1 0.468459442059375 0.02635007201346 -2.90717877329561 5.21593618536946e-08 mirMAP -1.59141472938909 1.02697373526982e-28 NA NA NA hsa-miR-16-5p PTGFR 0.468459442059375 0.02635007201346 -0.233414407535669 0.454209756675319 miRNATAP -0.70907436971604 1.00095637786516e-16 NA NA NA hsa-miR-16-5p PTGS1 0.468459442059375 0.02635007201346 -1.86379706848248 1.06731086101655e-15 miRNAWalker2_validate -0.373638552802657 9.56999347935986e-08 NA NA NA hsa-miR-16-5p PTGS2 0.468459442059375 0.02635007201346 0.00805602322749532 0.981456994390787 miRNAWalker2_validate;miRTarBase -0.362150730587735 0.000288682376482638 24759835;25196524 MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels;Artesunate induces apoptosis of bladder cancer cells by miR 16 regulation of COX 2 expression; Cyclooxygenase-2 COX-2 and miR-16 expression levels were determined with real-time PCR; ART efficiently inhibited orthotopic tumor growth in the bladder cancer rat which is accompanied with an increase of miR-16 expression and a decrease of COX-2 expression; ART significantly increased miR-16 expression and decreased the expression of COX-2 and the production of PGE2; More importantly down-regulation of miR-16 expression could reverse the effect of ART on apoptosis and COX-2 expression in bladder cells; In conclusion ART can elicit an anti-tumor effect against bladder cancer by up-regulation of miR-16 expression which resulted in the decrease of COX-2 expression and PGE2 production ; liver cancer;bladder cancer hsa-miR-16-5p PTHLH 0.468459442059375 0.02635007201346 -0.698481509843736 0.00799227292455291 MirTarget -0.481056184154002 9.75543729858034e-11 NA NA NA hsa-miR-16-5p PTPDC1 0.468459442059375 0.02635007201346 0.136577706099486 0.207848124475772 miRNAWalker2_validate -0.186191854072448 9.39643548500155e-10 NA NA NA hsa-miR-16-5p PTPN14 0.468459442059375 0.02635007201346 0.144321960759363 0.345946539624122 MirTarget -0.318435294606885 5.24079040444774e-14 NA NA NA hsa-miR-16-5p PTPRD 0.468459442059375 0.02635007201346 -1.00502953098866 0.000637604436440412 miRNATAP -0.468371483110919 2.78222032992547e-08 NA NA NA hsa-miR-16-5p PTPRT 0.468459442059375 0.02635007201346 -0.907265605799675 0.0372664951342187 miRNAWalker2_validate -0.462439084316095 0.000243715742899607 NA NA NA hsa-miR-16-5p PURA 0.468459442059375 0.02635007201346 -0.330747450626133 0.000135621233435024 miRNAWalker2_validate;miRTarBase;MirTarget -0.182960303285286 3.03154618981398e-14 NA NA NA hsa-miR-16-5p PURB 0.468459442059375 0.02635007201346 0.191156761618797 0.0680497522728757 miRNATAP -0.227879719111687 2.26202165437718e-15 NA NA NA hsa-miR-16-5p RAB11FIP2 0.468459442059375 0.02635007201346 -0.259679029578217 0.0617021736002116 MirTarget;miRNATAP -0.257355160974461 3.84904952790029e-11 NA NA NA hsa-miR-16-5p RAB12 0.468459442059375 0.02635007201346 -0.331725395446472 0.00841506962855526 miRNAWalker2_validate -0.290543508736331 3.56917629561853e-17 NA NA NA hsa-miR-16-5p RAB23 0.468459442059375 0.02635007201346 -0.096112489735301 0.66521993302631 miRNAWalker2_validate -0.6738051880175 3.41584361913502e-32 NA NA NA hsa-miR-16-5p RAB30 0.468459442059375 0.02635007201346 -1.42442211692912 3.65381677106471e-13 miRNAWalker2_validate -0.125811085579793 0.0352492091272099 NA NA NA hsa-miR-16-5p RAB6B 0.468459442059375 0.02635007201346 -1.20336252314016 2.74022582273913e-07 mirMAP -0.549188147971282 5.39750018424637e-17 NA NA NA hsa-miR-16-5p RAB9B 0.468459442059375 0.02635007201346 -1.64127232803465 2.08021776444596e-07 miRNAWalker2_validate -0.937263623967241 1.43880004216929e-28 NA NA NA hsa-miR-16-5p RABGAP1 0.468459442059375 0.02635007201346 -0.106752464617506 0.378462368364444 MirTarget -0.305147682837445 5.72916017076129e-21 NA NA NA hsa-miR-139-5p RAD21 -1.41674256628297 4.51005988644234e-14 0.582898829802627 2.35969807366732e-08 miRanda -0.215729977994839 1.74578031925924e-11 NA NA NA hsa-miR-195-3p RAD21 -0.694544351365025 0.000214711021317786 0.582898829802627 2.35969807366732e-08 MirTarget;miRNATAP -0.203922892511751 1.53267065881762e-09 NA NA NA hsa-miR-199a-5p RAD21 0.723739336873244 5.69674696426761e-05 0.582898829802627 2.35969807366732e-08 miRanda -0.132419058887897 0.000223159810510932 NA NA NA hsa-miR-199b-5p RAD21 0.621733599295605 0.000811860893066088 0.582898829802627 2.35969807366732e-08 miRanda -0.145009385749296 3.01127841290426e-05 NA NA NA hsa-miR-30a-3p RAD21 -1.27950866170419 4.33230022379782e-09 0.582898829802627 2.35969807366732e-08 MirTarget -0.23127705683316 3.80077592139038e-17 NA NA NA hsa-miR-30e-3p RAD21 -0.444998679251398 0.000501880465265124 0.582898829802627 2.35969807366732e-08 MirTarget -0.149393457427142 0.00379115533742456 NA NA NA hsa-miR-16-5p RAD50 0.468459442059375 0.02635007201346 0.108139021675818 0.233439037777841 MirTarget -0.117797117831272 4.93927267902632e-06 NA NA NA hsa-miR-16-5p RAPGEF2 0.468459442059375 0.02635007201346 -0.124525519850816 0.180177043283971 miRNATAP -0.13645236867448 2.06458361223836e-07 NA NA NA hsa-miR-16-5p RARB 0.468459442059375 0.02635007201346 -0.824546396136413 1.67331828630351e-05 miRNATAP -0.345503848493916 2.71294108243076e-10 NA NA NA hsa-miR-16-5p RASA4 0.468459442059375 0.02635007201346 -0.702098653804009 8.48703305158542e-05 mirMAP -0.309711111170432 1.26620138465406e-09 NA NA NA hsa-miR-16-5p RASL12 0.468459442059375 0.02635007201346 -0.396801549711893 0.0656479695578191 miRNATAP -0.484534861107323 2.83921320057018e-16 NA NA NA hsa-miR-16-5p RASSF2 0.468459442059375 0.02635007201346 -0.273260229164372 0.2196076417753 MirTarget -0.232698429918242 0.00028901229206917 NA NA NA hsa-miR-16-5p RASSF8 0.468459442059375 0.02635007201346 -0.121570136144733 0.655913644139023 miRNATAP -0.75489970498589 9.34479005994591e-26 NA NA NA hsa-miR-125a-3p RB1 0.0862037949225951 0.688453004025032 0.382005478821116 0.00169525673349234 miRanda -0.147112205057284 2.69093769722472e-05 NA NA NA hsa-miR-125a-5p RB1 -0.261743402170195 0.116107665196876 0.382005478821116 0.00169525673349234 miRanda -0.246459143002574 2.60286604691696e-08 NA NA NA hsa-miR-149-5p RB1 -0.814305489055795 0.00575972754574164 0.382005478821116 0.00169525673349234 miRNAWalker2_validate -0.141483321438582 8.35265626799694e-09 NA NA NA hsa-miR-26a-5p RB1 -0.507487084157331 3.23715933371269e-05 0.382005478821116 0.00169525673349234 miRNAWalker2_validate;miRTarBase;MirTarget -0.2701133062242 9.6978857365284e-06 NA NA NA hsa-miR-26b-5p RB1 -0.499493687076043 0.0118149973400486 0.382005478821116 0.00169525673349234 MirTarget -0.125782717694252 0.000808270386681212 NA NA NA hsa-miR-30a-3p RB1 -1.27950866170419 4.33230022379782e-09 0.382005478821116 0.00169525673349234 MirTarget -0.165936651616369 4.14501632334832e-07 NA NA NA hsa-miR-30e-3p RB1 -0.444998679251398 0.000501880465265124 0.382005478821116 0.00169525673349234 MirTarget -0.184809738976107 0.00172604244273291 NA NA NA hsa-miR-337-3p RB1 -0.228166532308969 0.303588587461454 0.382005478821116 0.00169525673349234 PITA -0.16349020801966 8.92628219209215e-07 NA NA NA hsa-miR-16-5p RBBP6 0.468459442059375 0.02635007201346 0.162900336526808 0.0510081318834689 MirTarget;miRNATAP -0.104002356169257 1.22080332782826e-05 NA NA NA hsa-miR-16-5p RBFOX2 0.468459442059375 0.02635007201346 -0.23382535811194 0.0474300848701291 miRNATAP -0.332966917549835 4.84940739673868e-27 NA NA NA hsa-miR-129-5p RBL1 -1.61803714443871 4.93214379865694e-06 1.13868884141697 6.57958844329849e-15 miRanda -0.113479317957448 1.55532317560939e-05 NA NA NA hsa-miR-195-3p RBL1 -0.694544351365025 0.000214711021317786 1.13868884141697 6.57958844329849e-15 MirTarget;mirMAP -0.264197525342032 7.17643876296791e-08 NA NA NA hsa-miR-199a-5p RBL1 0.723739336873244 5.69674696426761e-05 1.13868884141697 6.57958844329849e-15 miRanda -0.131835586201527 0.0114154669620617 NA NA NA hsa-miR-199b-5p RBL1 0.621733599295605 0.000811860893066088 1.13868884141697 6.57958844329849e-15 miRanda -0.128499159410304 0.0112046817325941 NA NA NA hsa-miR-495-3p RBL1 -0.024887553302567 0.897251687801771 1.13868884141697 6.57958844329849e-15 mirMAP -0.142706599914256 0.0037186436503976 NA NA NA hsa-miR-106b-5p RBL2 1.08518388423396 4.82746923373852e-09 -0.281923008753179 0.0025386513501511 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.218914216379717 2.28081773738246e-14 NA NA NA hsa-miR-107 RBL2 0.85152957824299 1.22369651446858e-11 -0.281923008753179 0.0025386513501511 miRanda -0.153779671526079 0.000526538453491591 NA NA NA hsa-miR-126-5p RBL2 0.450893496822779 0.0112966412858755 -0.281923008753179 0.0025386513501511 MirTarget -0.20048469962559 1.2884420931613e-10 NA NA NA hsa-miR-140-5p RBL2 0.132398579631585 0.457960134430787 -0.281923008753179 0.0025386513501511 miRanda -0.188470743759536 2.05536931260506e-09 NA NA NA hsa-miR-142-5p RBL2 1.08445947321046 0.000126372881543671 -0.281923008753179 0.0025386513501511 PITA -0.112077298435917 8.25146121027264e-09 NA NA NA hsa-miR-17-5p RBL2 1.57209612312313 5.10453838016207e-11 -0.281923008753179 0.0025386513501511 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.140611586537728 2.86701531516767e-10 NA NA NA hsa-miR-23a-3p RBL2 0.694558223570443 8.99413995422816e-10 -0.281923008753179 0.0025386513501511 MirTarget -0.145701512603368 0.00359776963597081 NA NA NA hsa-miR-26a-2-3p RBL2 0.0619487388777404 0.765401751442771 -0.281923008753179 0.0025386513501511 MirTarget -0.120570364856211 1.43348621582053e-05 NA NA NA hsa-miR-335-3p RBL2 2.29463721765513 4.1956113745077e-18 -0.281923008753179 0.0025386513501511 MirTarget -0.101333197845206 3.17736538992929e-07 NA NA NA hsa-miR-335-5p RBL2 0.576542642348884 0.01886326850059 -0.281923008753179 0.0025386513501511 miRNAWalker2_validate -0.147435330318003 6.08888636084796e-11 NA NA NA hsa-miR-421 RBL2 1.26653675546617 2.35180826009926e-08 -0.281923008753179 0.0025386513501511 miRanda -0.114139968567765 3.09461688719248e-06 NA NA NA hsa-miR-576-5p RBL2 0.872721964495849 5.20470410008775e-05 -0.281923008753179 0.0025386513501511 MirTarget;PITA -0.171721516819629 1.0649270537075e-11 NA NA NA hsa-miR-590-3p RBL2 0.858742926831233 0.000127281269371976 -0.281923008753179 0.0025386513501511 miRanda -0.142287120989253 8.16068729560111e-09 NA NA NA hsa-miR-629-3p RBL2 0.597278340934362 0.0508108703940013 -0.281923008753179 0.0025386513501511 MirTarget -0.122313481343175 2.54995878640829e-10 NA NA NA hsa-miR-16-5p RBM6 0.468459442059375 0.02635007201346 -0.136802087204089 0.156630751376673 miRNAWalker2_validate;MirTarget;miRNATAP -0.132958890718163 1.24238432010579e-06 NA NA NA hsa-miR-16-5p RBMS1 0.468459442059375 0.02635007201346 -0.0436443770031296 0.808758050496525 miRNAWalker2_validate;miRNATAP -0.433582734141843 6.75054712984761e-19 NA NA NA hsa-miR-16-5p RBMS3 0.468459442059375 0.02635007201346 -0.518802275066789 0.0355078319259322 miRNAWalker2_validate -0.778015404025929 3.97188248912575e-35 NA NA NA hsa-miR-16-5p RBPJ 0.468459442059375 0.02635007201346 0.233248695691198 0.00585943920555178 MirTarget -0.116572881434535 1.33044904839034e-06 NA NA NA hsa-miR-16-5p RCOR3 0.468459442059375 0.02635007201346 -0.119702410705573 0.230476107003849 MirTarget;miRNATAP -0.195611844991658 1.50007450356997e-12 NA NA NA hsa-miR-16-5p RECK 0.468459442059375 0.02635007201346 -1.04347373160309 9.33987268915419e-07 miRNAWalker2_validate;miRNATAP -0.562736911936963 3.98354630375811e-22 24852767 Aberrant expression level of miR-16 could suppress cell apoptosis while promote growth by regulating RECK and SOX6 which play important roles in the pathogenesis of ESCC esophageal cancer hsa-miR-16-5p REEP1 0.468459442059375 0.02635007201346 -2.11544155777275 2.02942413315448e-07 MirTarget -1.02324321272338 1.28851507387305e-19 NA NA NA hsa-miR-16-5p RELN 0.468459442059375 0.02635007201346 -2.4032593050865 9.46041009197227e-10 MirTarget;miRNATAP -0.791658012633644 2.95909625213297e-12 NA NA NA hsa-miR-16-5p RET 0.468459442059375 0.02635007201346 -0.832755310542644 0.0351710970965439 MirTarget;miRNATAP -0.61524719187578 4.72922626906929e-08 NA NA NA hsa-miR-16-5p RGMA 0.468459442059375 0.02635007201346 -1.78164228251851 1.98608269949397e-05 MirTarget -1.23277531556544 8.21847748889296e-29 NA NA NA hsa-miR-16-5p RGS22 0.468459442059375 0.02635007201346 -0.776438245096146 0.0273705723760213 MirTarget -0.797416216907719 1.83409542464534e-16 NA NA NA hsa-miR-16-5p RHOT1 0.468459442059375 0.02635007201346 -0.195553531910098 0.0259073751726022 miRNAWalker2_validate -0.138123769184172 2.48702453754057e-08 NA NA NA hsa-miR-16-5p RICTOR 0.468459442059375 0.02635007201346 0.387516049901938 0.00188233465370784 MirTarget;miRNATAP -0.216103536683984 9.28990873731925e-10 NA NA NA hsa-miR-16-5p RIMKLB 0.468459442059375 0.02635007201346 -0.516647470958743 0.0376812451743227 MirTarget;miRNATAP -0.557214497822668 3.88640121791828e-16 NA NA NA hsa-miR-16-5p RIMS3 0.468459442059375 0.02635007201346 -1.3046164844765 2.73366807369862e-06 miRNAWalker2_validate -0.550039719466871 3.74243897805133e-12 NA NA NA hsa-miR-16-5p RNASEL 0.468459442059375 0.02635007201346 -0.27246163032033 0.0179637269468357 miRNAWalker2_validate -0.172723568473355 1.33038747089204e-07 NA NA NA hsa-miR-16-5p RNF125 0.468459442059375 0.02635007201346 -0.207018424430671 0.265318718636139 MirTarget;miRNATAP -0.202817068362318 0.000149410769320386 NA NA NA hsa-miR-16-5p RNF144B 0.468459442059375 0.02635007201346 -0.292369081593336 0.117661251051104 miRNAWalker2_validate;miRNATAP -0.175120544002421 0.00119175492332007 NA NA NA hsa-miR-16-5p RNF165 0.468459442059375 0.02635007201346 -1.11992889821903 0.00120651282301094 MirTarget -0.841019558275905 7.00319445233965e-19 NA NA NA hsa-miR-16-5p RNF217 0.468459442059375 0.02635007201346 -1.00205335921036 2.29819486137061e-05 miRNAWalker2_validate;MirTarget -0.576352037429345 1.07776787967825e-18 NA NA NA hsa-miR-16-5p ROGDI 0.468459442059375 0.02635007201346 -1.12436032365551 2.83525909681017e-19 miRNAWalker2_validate -0.126229750634274 0.00115793714770512 NA NA NA hsa-miR-16-5p ROR1 0.468459442059375 0.02635007201346 -0.861512083100719 0.000181264380069288 miRNATAP -0.390396323575309 2.93620002334994e-09 NA NA NA hsa-miR-16-5p RORA 0.468459442059375 0.02635007201346 -0.888667376601635 4.99889595160793e-06 MirTarget;miRNATAP -0.449217163889911 1.28438042075818e-16 NA NA NA hsa-miR-16-5p RP1L1 0.468459442059375 0.02635007201346 1.27544749144584 3.42791404299589e-05 miRNAWalker2_validate -0.312292145689782 0.000540162921082012 NA NA NA hsa-miR-16-5p RPRD2 0.468459442059375 0.02635007201346 0.182394409646447 0.028243213211986 miRNAWalker2_validate;MirTarget -0.126071300473449 7.9826436344628e-08 NA NA NA hsa-miR-16-5p RPS27 0.468459442059375 0.02635007201346 -0.156748223888344 0.481779147298345 miRNAWalker2_validate -0.482045175769911 3.97452664881238e-15 NA NA NA hsa-miR-16-5p RPS6KA3 0.468459442059375 0.02635007201346 0.25562324842552 0.02419259011319 miRNAWalker2_validate;MirTarget;miRNATAP -0.116897535257014 0.00034909796510496 NA NA NA hsa-miR-16-5p RPS6KA6 0.468459442059375 0.02635007201346 -2.98891177318268 6.67782798681791e-14 MirTarget -0.942831663960455 2.77048727579972e-16 NA NA NA hsa-miR-16-5p RSBN1 0.468459442059375 0.02635007201346 -0.0117811591151229 0.891572467045118 MirTarget;miRNATAP -0.112507015615545 4.38903900500146e-06 NA NA NA hsa-miR-16-5p RSPO3 0.468459442059375 0.02635007201346 -0.413092961972705 0.273194842658858 MirTarget -0.856831072178301 1.10091617031347e-16 NA NA NA hsa-miR-16-5p RTN4 0.468459442059375 0.02635007201346 -0.411549538148011 0.000141083434427497 miRNAWalker2_validate -0.220444310928212 3.29180405695384e-13 NA NA NA hsa-miR-16-5p RUNDC3B 0.468459442059375 0.02635007201346 -1.01699292837566 1.21190372674825e-05 miRNAWalker2_validate;MirTarget -0.466270812079016 1.42648320718613e-12 NA NA NA hsa-miR-16-5p RUNX1T1 0.468459442059375 0.02635007201346 -0.344000642439472 0.237404358600589 miRNAWalker2_validate;miRNATAP -0.853448907170192 1.86625514022948e-29 NA NA NA hsa-miR-16-5p RYBP 0.468459442059375 0.02635007201346 -0.114507030284895 0.11900576425575 MirTarget -0.118095377759668 9.28085076915677e-09 NA NA NA hsa-miR-16-5p SAMD4A 0.468459442059375 0.02635007201346 -0.132799293939158 0.555317186016636 MirTarget -0.610919118699233 1.22566078386166e-24 NA NA NA hsa-miR-16-5p SARM1 0.468459442059375 0.02635007201346 -0.515539220220322 0.000237694974843706 mirMAP -0.150847028681597 0.000218351389584984 NA NA NA hsa-miR-16-5p SAV1 0.468459442059375 0.02635007201346 -0.016098543470858 0.880390578434833 miRNAWalker2_validate -0.103955503450016 0.000711268120717686 NA NA NA hsa-miR-16-5p SCN2A 0.468459442059375 0.02635007201346 0.317164447705599 0.477497388671926 MirTarget -0.499338242385822 0.000102478140329756 NA NA NA hsa-miR-16-5p SCN2B 0.468459442059375 0.02635007201346 -2.22237853128849 2.58947336008345e-06 mirMAP -1.29414691030452 6.17651511646864e-24 NA NA NA hsa-miR-16-5p SCN3A 0.468459442059375 0.02635007201346 -1.5009210460306 8.66949811687225e-07 MirTarget -0.446655763921277 5.0798896298024e-07 NA NA NA hsa-miR-16-5p SCN4B 0.468459442059375 0.02635007201346 -1.50190480797345 2.55846292929615e-07 miRNATAP -0.651032178217824 2.40672662136734e-15 NA NA NA hsa-miR-16-5p SDC3 0.468459442059375 0.02635007201346 0.0412816778750296 0.815551299654887 mirMAP -0.347170643968746 1.72505827970293e-12 NA NA NA hsa-miR-16-5p SEC14L5 0.468459442059375 0.02635007201346 -2.00691526440237 3.58158652448988e-07 mirMAP -0.297667492759 0.0110835612438782 NA NA NA hsa-miR-16-5p SEC24B 0.468459442059375 0.02635007201346 -0.192388173024879 0.0123756666560841 miRNAWalker2_validate -0.11170858106646 2.88797662266644e-07 NA NA NA hsa-miR-16-5p SEMA3A 0.468459442059375 0.02635007201346 -0.179919346499373 0.561052089127856 MirTarget -0.673879056265064 2.62219404483499e-15 NA NA NA hsa-miR-16-5p SEMA3D 0.468459442059375 0.02635007201346 -1.73377572221593 1.94522521277914e-05 MirTarget;miRNATAP -0.7015294695163 1.71667994767675e-09 NA NA NA hsa-miR-16-5p SEMA4C 0.468459442059375 0.02635007201346 0.0997965897725477 0.505275274064598 miRNAWalker2_validate -0.282142181036911 1.46787972008804e-11 NA NA NA hsa-miR-16-5p SEMA6A 0.468459442059375 0.02635007201346 -0.78947725978746 0.0133684925524848 miRNATAP -0.502549626984033 3.34823133219488e-08 NA NA NA hsa-miR-16-5p SEMA6D 0.468459442059375 0.02635007201346 -1.55565558119296 1.29394597397564e-07 miRNATAP -0.443014428681467 2.63864913968424e-07 NA NA NA hsa-miR-16-5p SENP6 0.468459442059375 0.02635007201346 0.0812810872614262 0.402002112808971 miRNAWalker2_validate -0.182872490417686 1.12055764708306e-11 NA NA NA hsa-miR-16-5p SEPT2 0.468459442059375 0.02635007201346 0.106596320652431 0.143786999211975 MirTarget;miRNATAP -0.107335841877806 1.66584924066237e-07 NA NA NA hsa-miR-16-5p SERPINE2 0.468459442059375 0.02635007201346 0.124636258296181 0.636118825227613 miRNAWalker2_validate -0.3812159467436 3.72390224976044e-07 NA NA NA hsa-miR-16-5p SESN1 0.468459442059375 0.02635007201346 -0.316273897424733 0.0791103584277436 MirTarget;miRNATAP -0.144002090355108 0.00585585033060321 NA NA NA hsa-miR-16-5p SETD3 0.468459442059375 0.02635007201346 -0.269700648406957 0.000669748960778885 MirTarget -0.11536248704199 3.23383700076263e-07 NA NA NA hsa-miR-16-5p SGCA 0.468459442059375 0.02635007201346 -2.54874692316998 3.73843198020006e-09 MirTarget -1.13804092421145 2.34574733942828e-21 NA NA NA hsa-miR-16-5p SGCD 0.468459442059375 0.02635007201346 -0.462258493991732 0.100341438431502 miRNATAP -0.886687618531461 3.2148132857842e-35 NA NA NA hsa-miR-16-5p SH3GL2 0.468459442059375 0.02635007201346 -4.46378118219411 1.17801358444675e-19 MirTarget;miRNATAP -0.649291601038403 2.01744265854715e-05 NA NA NA hsa-miR-16-5p SH3PXD2B 0.468459442059375 0.02635007201346 0.571146620240805 0.000639832838972146 mirMAP -0.335379399892852 9.25658977367829e-13 NA NA NA hsa-miR-16-5p SHE 0.468459442059375 0.02635007201346 -0.487657055801679 0.0132219991840013 mirMAP -0.393080524369104 8.88721258299005e-13 NA NA NA hsa-miR-16-5p SHROOM4 0.468459442059375 0.02635007201346 0.533433249282303 0.0033357310845142 miRNATAP -0.331517193863002 1.06346392921865e-10 NA NA NA hsa-miR-16-5p SIAH1 0.468459442059375 0.02635007201346 -0.0573266239623029 0.414147265510872 miRNATAP -0.122655937983167 2.99039931302322e-10 NA NA NA hsa-miR-16-5p SIPA1L2 0.468459442059375 0.02635007201346 -0.0621530457804553 0.741518280681569 miRNAWalker2_validate;miRNATAP -0.387629937166129 1.06091042613707e-13 NA NA NA hsa-miR-16-5p SIRT4 0.468459442059375 0.02635007201346 -0.987112069506048 3.83745090789457e-09 miRNAWalker2_validate;MirTarget -0.265363609692451 6.28479478743375e-08 NA NA NA hsa-miR-16-5p SKAP2 0.468459442059375 0.02635007201346 0.107562936565811 0.411549515152348 miRNAWalker2_validate -0.245937881910346 1.65649928500954e-11 NA NA NA hsa-miR-16-5p SKI 0.468459442059375 0.02635007201346 0.22417153228759 0.0311770228305296 MirTarget;miRNATAP -0.185743944393448 1.93936523670243e-10 NA NA NA hsa-miR-107 SKP1 0.85152957824299 1.22369651446858e-11 -0.548078679707717 4.5921143965305e-10 miRanda -0.275025859253799 4.0938047584375e-11 NA NA NA hsa-miR-1301-3p SKP1 1.62626930622185 2.81303026159352e-11 -0.548078679707717 4.5921143965305e-10 miRNAWalker2_validate -0.113976279902926 9.0932729820053e-08 NA NA NA hsa-miR-130b-3p SKP1 1.29757792612022 1.70655148591568e-06 -0.548078679707717 4.5921143965305e-10 MirTarget -0.105055541224109 7.95433236976247e-08 NA NA NA hsa-miR-148b-3p SKP1 0.719517328390822 3.51245964668412e-05 -0.548078679707717 4.5921143965305e-10 MirTarget -0.190410121787295 5.33656301758751e-10 NA NA NA hsa-miR-151a-5p SKP1 0.897578755117332 4.82602190477219e-06 -0.548078679707717 4.5921143965305e-10 miRNAWalker2_validate -0.106048458821012 0.000121282748684527 NA NA NA hsa-miR-222-3p SKP1 1.50650995841483 1.51287294049382e-09 -0.548078679707717 4.5921143965305e-10 MirTarget -0.112572088074134 8.85288250595293e-08 NA NA NA hsa-miR-3913-5p SKP1 1.03696691062365 1.67224447360466e-09 -0.548078679707717 4.5921143965305e-10 MirTarget -0.143926192435663 3.61388521990899e-06 NA NA NA hsa-miR-450b-5p SKP1 1.36137774989901 7.45499130609203e-11 -0.548078679707717 4.5921143965305e-10 miRNATAP -0.123096762313139 9.75972625687943e-07 NA NA NA hsa-miR-7-1-3p SKP1 0.94398354303717 7.5771319809992e-05 -0.548078679707717 4.5921143965305e-10 MirTarget;mirMAP -0.104933318731799 3.39509150742036e-06 NA NA NA hsa-miR-26a-5p SKP2 -0.507487084157331 3.23715933371269e-05 1.14586647906573 1.54854346919136e-10 MirTarget -0.404422530556961 1.30076958699205e-05 NA NA NA hsa-miR-30a-5p SKP2 -0.742755040631906 3.79943871404435e-05 1.14586647906573 1.54854346919136e-10 MirTarget;miRNATAP -0.529437139508704 1.04743562051899e-19 NA NA NA hsa-miR-30c-5p SKP2 -0.172645077009891 0.276411433016536 1.14586647906573 1.54854346919136e-10 MirTarget;miRNATAP -0.253330105537257 0.000438845609293174 NA NA NA hsa-miR-16-5p SLC20A2 0.468459442059375 0.02635007201346 -0.28088699049617 0.0323486031823865 miRNATAP -0.200028903392545 8.23947219322022e-08 NA NA NA hsa-miR-16-5p SLC24A3 0.468459442059375 0.02635007201346 -0.167053424506094 0.514545085375566 miRNATAP -0.508288892828476 1.02051379807541e-12 NA NA NA hsa-miR-16-5p SLC25A12 0.468459442059375 0.02635007201346 -0.5289350164542 0.000602375078491444 MirTarget -0.346511700086447 4.72950525993153e-16 NA NA NA hsa-miR-16-5p SLC25A26 0.468459442059375 0.02635007201346 -0.394703690472408 0.00169663064559881 mirMAP -0.270412491006002 9.02909051781102e-15 NA NA NA hsa-miR-16-5p SLC29A1 0.468459442059375 0.02635007201346 -0.382382190790867 0.0143276249757502 miRNAWalker2_validate -0.168075959970885 0.000195319256255093 NA NA NA hsa-miR-16-5p SLC30A8 0.468459442059375 0.02635007201346 -2.65731049044966 2.93491403185427e-09 MirTarget -0.923925271500076 7.01526897334643e-13 NA NA NA hsa-miR-16-5p SLC38A1 0.468459442059375 0.02635007201346 0.165523798697978 0.414141102706905 miRNAWalker2_validate -0.346267168061269 1.33376566926117e-09 NA NA NA hsa-miR-16-5p SLC38A2 0.468459442059375 0.02635007201346 -0.034759634518049 0.752300156668015 miRNAWalker2_validate -0.125594203898606 6.66734422290307e-05 NA NA NA hsa-miR-16-5p SLC39A13 0.468459442059375 0.02635007201346 0.279550795527371 0.00388087580321591 mirMAP -0.100626234558429 0.000314817924757874 NA NA NA hsa-miR-16-5p SLC6A4 0.468459442059375 0.02635007201346 -3.68262138749367 4.59780243174991e-13 MirTarget;miRNATAP -0.459009736875862 0.00299974832332632 NA NA NA hsa-miR-16-5p SLC7A2 0.468459442059375 0.02635007201346 -0.504055476896812 0.159045414836461 MirTarget;miRNATAP -0.530718109472187 1.96458066368211e-07 NA NA NA hsa-let-7a-3p SMAD2 0.283468597868531 0.127007787220086 -0.127583060413726 0.127322899257877 mirMAP -0.106101759255441 0.000100303444197151 NA NA NA hsa-let-7b-3p SMAD2 0.377956364821509 0.0061730103051373 -0.127583060413726 0.127322899257877 mirMAP -0.11319020038656 0.00230362474156071 NA NA NA hsa-let-7f-1-3p SMAD2 1.09636075438131 3.42037366931931e-10 -0.127583060413726 0.127322899257877 mirMAP -0.100461508135326 0.000354947451412854 NA NA NA hsa-miR-106b-5p SMAD2 1.08518388423396 4.82746923373852e-09 -0.127583060413726 0.127322899257877 mirMAP -0.109902235320899 3.28668167656852e-05 NA NA NA hsa-miR-142-5p SMAD2 1.08445947321046 0.000126372881543671 -0.127583060413726 0.127322899257877 mirMAP;miRNATAP -0.110568024743433 1.1149349680788e-10 NA NA NA hsa-miR-148b-3p SMAD2 0.719517328390822 3.51245964668412e-05 -0.127583060413726 0.127322899257877 MirTarget;mirMAP -0.136810269145914 1.68238174009693e-06 NA NA NA hsa-miR-155-5p SMAD2 0.708423342476697 0.00686702252429413 -0.127583060413726 0.127322899257877 miRNAWalker2_validate;miRTarBase;MirTarget;mirMAP -0.104705142933411 2.71595551370121e-08 22426647;25283513 Taken together these data suggest that miR-155 may function as a tumor suppressor to regulate gastric cancer cell metastasis by targeting SMAD2 and its downregulation in gastric cancer cells may be partly ascribed to DNA methylation;MiR-155 which targeted the SMAD2-3'UTR decreased the expression and function of SMAD2 metastasis; gastric cancer;prostate cancer hsa-miR-186-5p SMAD2 0.35512789129261 0.0196931838168008 -0.127583060413726 0.127322899257877 mirMAP -0.10283948247702 0.00219201376868083 NA NA NA hsa-miR-212-3p SMAD2 0.810640598956005 2.08058512206955e-06 -0.127583060413726 0.127322899257877 MirTarget -0.122412590328633 2.58758943180455e-05 NA NA NA hsa-miR-26a-5p SMAD2 -0.507487084157331 3.23715933371269e-05 -0.127583060413726 0.127322899257877 mirMAP -0.174225805102639 2.7315030695384e-05 NA NA NA hsa-miR-26b-5p SMAD2 -0.499493687076043 0.0118149973400486 -0.127583060413726 0.127322899257877 mirMAP -0.100120618576573 8.03405526518063e-05 NA NA NA hsa-miR-30e-3p SMAD2 -0.444998679251398 0.000501880465265124 -0.127583060413726 0.127322899257877 mirMAP -0.110736123708528 0.00578441961666557 NA NA NA hsa-miR-361-3p SMAD2 0.485361250955594 0.00074097948047418 -0.127583060413726 0.127322899257877 miRNATAP -0.108649584013497 0.00216027730733127 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-miR-3613-5p SMAD2 1.03938524872813 2.63575941507995e-05 -0.127583060413726 0.127322899257877 mirMAP -0.113531996044768 9.60967230032425e-09 NA NA NA hsa-miR-374a-5p SMAD2 0.239597788731458 0.0202963000797544 -0.127583060413726 0.127322899257877 MirTarget -0.149326836629435 0.00327268419601322 NA NA NA hsa-miR-374b-5p SMAD2 0.00249900187478502 0.985380083859555 -0.127583060413726 0.127322899257877 MirTarget -0.156419618593836 3.17442052120825e-05 NA NA NA hsa-miR-450b-5p SMAD2 1.36137774989901 7.45499130609203e-11 -0.127583060413726 0.127322899257877 mirMAP -0.10159272893609 1.17889003663917e-05 NA NA NA hsa-miR-455-5p SMAD2 0.644390760445571 0.00262275997170695 -0.127583060413726 0.127322899257877 miRanda -0.101824890946511 1.28998280388769e-05 NA NA NA hsa-miR-484 SMAD2 0.401753773460753 0.0490851523101605 -0.127583060413726 0.127322899257877 miRNAWalker2_validate -0.12218203276992 6.12708677691158e-07 NA NA NA hsa-miR-542-3p SMAD2 1.12416854979951 1.02649534578738e-12 -0.127583060413726 0.127322899257877 PITA -0.11939429643036 0.000108480960132617 NA NA NA hsa-miR-590-3p SMAD2 0.858742926831233 0.000127281269371976 -0.127583060413726 0.127322899257877 MirTarget;PITA;mirMAP;miRNATAP -0.10601759948264 1.67499305640438e-06 NA NA NA hsa-let-7a-3p SMAD4 0.283468597868531 0.127007787220086 -0.31259096016241 0.0041260218763756 mirMAP -0.158754110657301 8.82154754138378e-06 NA NA NA hsa-let-7b-3p SMAD4 0.377956364821509 0.0061730103051373 -0.31259096016241 0.0041260218763756 mirMAP -0.149167029513993 0.00225841088076548 NA NA NA hsa-let-7f-1-3p SMAD4 1.09636075438131 3.42037366931931e-10 -0.31259096016241 0.0041260218763756 mirMAP -0.166570671732699 5.74927260212123e-06 NA NA NA hsa-miR-106b-5p SMAD4 1.08518388423396 4.82746923373852e-09 -0.31259096016241 0.0041260218763756 mirMAP;miRNATAP -0.184533736765317 8.39518666522128e-08 NA NA NA hsa-miR-10b-3p SMAD4 0.448860145188521 0.00703361939318676 -0.31259096016241 0.0041260218763756 miRNATAP -0.159407724307957 6.79848993859667e-05 NA NA NA hsa-miR-125a-3p SMAD4 0.0862037949225951 0.688453004025032 -0.31259096016241 0.0041260218763756 MirTarget;PITA;miRanda -0.115735289470815 0.000229466269924128 NA NA NA hsa-miR-126-5p SMAD4 0.450893496822779 0.0112966412858755 -0.31259096016241 0.0041260218763756 mirMAP -0.178764449211864 1.40878157147875e-06 NA NA NA hsa-miR-130a-3p SMAD4 0.218018009582956 0.274232880676821 -0.31259096016241 0.0041260218763756 miRNAWalker2_validate;miRNATAP -0.113149137574814 0.000735997420311438 NA NA NA hsa-miR-130b-3p SMAD4 1.29757792612022 1.70655148591568e-06 -0.31259096016241 0.0041260218763756 miRNAWalker2_validate;miRNATAP -0.139975983216462 2.52861296124715e-09 NA NA NA hsa-miR-140-5p SMAD4 0.132398579631585 0.457960134430787 -0.31259096016241 0.0041260218763756 miRanda -0.132838174744716 0.000405083571693904 NA NA NA hsa-miR-142-5p SMAD4 1.08445947321046 0.000126372881543671 -0.31259096016241 0.0041260218763756 mirMAP -0.122968776338381 7.01570985560171e-08 NA NA NA hsa-miR-146a-5p SMAD4 0.801543189433048 0.00411744525146003 -0.31259096016241 0.0041260218763756 miRNAWalker2_validate;miRTarBase -0.11062787301315 2.24268345362731e-06 27438138;22020746;21982769 SMAD4 was identified as a miR-146a target and was downregulated in BARF1-expressing cells whereas SMAD4 expression was restored by anti-miR-146a; Knockdown of BARF1 in YCCEL1 cells upregulated SMAD4 and this effect was reversed by miR-146a overexpression; In stomach cancer tissues miR-146a was expressed at higher levels and more frequent NFκB nuclear positivity immunohistochemically but not of SMAD4 nuclear loss was found in the EBV-positive group compared with the EBV-negative group; In conclusion EBV-encoded BARF1 promotes cell proliferation in stomach cancer by upregulating NFκB and miR-146a and downregulating SMAD4 thereby contributing to EBV-induced stomach cancer progression;Increased miR 146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis; Using target prediction algorithms luciferase reporter assay and Western blot assay SMAD family member 4 SMAD4 was identified as a target gene of miR-146a in gastric cancer; Moreover an inverse correlation was observed between the expression of SMAD4 mRNA and miR-146a in gastric cancer tissues R=-0.731 P=0.039 Pearson's correlation; Taken together our results provide important evidence that miR-146a can directly target SMAD4 and suggest that miR-146a may play a role in the development of gastric cancer by modulating cell proliferation and apoptosis;The results indicated that miR-146a regulated the sensitivity of HCC cells to the cytotoxic effects of IFN-α through SMAD4 suggesting that this miRNA could be suitable for prediction of the clinical response and potential therapeutic target in HCC patients on IFN-based therapy progression;;drug resistance gastric cancer;gastric cancer;liver cancer hsa-miR-146b-5p SMAD4 2.23105707690238 3.83997814011313e-23 -0.31259096016241 0.0041260218763756 PITA;miRanda;miRNATAP -0.107002098376942 7.30024432164399e-05 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-155-5p SMAD4 0.708423342476697 0.00686702252429413 -0.31259096016241 0.0041260218763756 miRNAWalker2_validate -0.110361346500155 1.04894256533641e-05 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-186-5p SMAD4 0.35512789129261 0.0196931838168008 -0.31259096016241 0.0041260218763756 miRNAWalker2_validate;mirMAP -0.142855340576068 0.00120323356560019 NA NA NA hsa-miR-18a-5p SMAD4 2.04701000113742 1.30593450319289e-12 -0.31259096016241 0.0041260218763756 miRNAWalker2_validate -0.102223897399558 2.68354883367347e-06 NA NA NA hsa-miR-21-3p SMAD4 1.87780012411493 8.38052480155167e-17 -0.31259096016241 0.0041260218763756 mirMAP -0.141683159377289 2.21846815550061e-07 NA NA NA hsa-miR-2355-5p SMAD4 0.624463693002283 6.00185219101058e-05 -0.31259096016241 0.0041260218763756 MirTarget -0.145562327749666 0.000641834626866554 NA NA NA hsa-miR-25-3p SMAD4 0.948739680210032 3.62304579611938e-09 -0.31259096016241 0.0041260218763756 mirMAP -0.180794067126583 6.78771709744027e-06 NA NA NA hsa-miR-26a-5p SMAD4 -0.507487084157331 3.23715933371269e-05 -0.31259096016241 0.0041260218763756 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.144691235080344 0.00874593783404751 NA NA NA hsa-miR-26b-5p SMAD4 -0.499493687076043 0.0118149973400486 -0.31259096016241 0.0041260218763756 MirTarget;miRNATAP -0.115094993430442 0.000594240075621644 24890815 Overexpression of miR-26b also repressed Smad4 expression whereas its inhibition elevated Smad4 expression; In HCC cell lines miR-26b targeted the 3'UTR of USP9X which in turn affects EMT through Smad4 and the TGF-β signaling pathway liver cancer hsa-miR-27a-3p SMAD4 0.523219911315699 0.000116410279757859 -0.31259096016241 0.0041260218763756 MirTarget -0.230957844125686 2.14275721400976e-06 NA NA NA hsa-miR-301a-3p SMAD4 1.22580753116505 5.84016077664577e-09 -0.31259096016241 0.0041260218763756 miRNAWalker2_validate;miRNATAP -0.118088619576369 0.000116341473786965 26019136 MicroRNA 301a 3p promotes pancreatic cancer progression via negative regulation of SMAD4; Furthermore SMAD4 was identified as a target gene of miR-301a-3p by cell as well as mice xenograft experiments; In PDAC tissue microarray a significantly inverse correlation between miR-301a-3p ISH scores and SMAD4 IHC scores were observed in both tumor and corresponding non-tumor tissues; MiR-301a-3p functions as a novel oncogene in PDAC and the oncogenic activity may involve its inhibition of the target gene SMAD4 progression pancreatic cancer hsa-miR-30b-5p SMAD4 -0.0106833209203501 0.954966272944722 -0.31259096016241 0.0041260218763756 mirMAP -0.114984596748122 0.0011779253354481 NA NA NA hsa-miR-30e-5p SMAD4 -0.284839730810255 0.0405852891523165 -0.31259096016241 0.0041260218763756 mirMAP -0.108824159732308 0.0257557314841602 NA NA NA hsa-miR-32-5p SMAD4 0.425717775201634 0.0402079308210921 -0.31259096016241 0.0041260218763756 mirMAP -0.182839505390668 5.90087142829289e-09 NA NA NA hsa-miR-320b SMAD4 1.21733873788625 7.99882585998487e-07 -0.31259096016241 0.0041260218763756 miRNATAP -0.10330861405583 8.60793624505173e-05 NA NA NA hsa-miR-330-3p SMAD4 0.391166748754241 0.0581284813543685 -0.31259096016241 0.0041260218763756 mirMAP -0.11771738647317 0.000417415798096644 NA NA NA hsa-miR-34a-5p SMAD4 0.691825068787607 0.00069818668499891 -0.31259096016241 0.0041260218763756 miRNATAP -0.135747183616941 2.5237927208584e-05 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-361-5p SMAD4 0.538048008019709 1.61165802415302e-07 -0.31259096016241 0.0041260218763756 mirMAP -0.182566430585261 0.00549860480766203 NA NA NA hsa-miR-362-3p SMAD4 0.994614346444282 4.39793878186399e-05 -0.31259096016241 0.0041260218763756 miRNATAP -0.113269373606989 4.43595320356158e-05 NA NA NA hsa-miR-369-3p SMAD4 0.644921905467686 0.00104986428608648 -0.31259096016241 0.0041260218763756 mirMAP -0.131196688101098 9.83846265644443e-05 NA NA NA hsa-miR-374a-5p SMAD4 0.239597788731458 0.0202963000797544 -0.31259096016241 0.0041260218763756 mirMAP -0.235424569425845 0.000403255576234335 NA NA NA hsa-miR-374b-5p SMAD4 0.00249900187478502 0.985380083859555 -0.31259096016241 0.0041260218763756 mirMAP -0.168495947289316 0.000702283658138741 NA NA NA hsa-miR-409-3p SMAD4 1.02296003511803 1.54748197930307e-08 -0.31259096016241 0.0041260218763756 mirMAP -0.117954740135716 0.00105304417099389 NA NA NA hsa-miR-421 SMAD4 1.26653675546617 2.35180826009926e-08 -0.31259096016241 0.0041260218763756 miRTarBase;miRanda;miRNATAP -0.135415845522913 2.14509306787876e-06 NA NA NA hsa-miR-450b-5p SMAD4 1.36137774989901 7.45499130609203e-11 -0.31259096016241 0.0041260218763756 mirMAP -0.115896738428018 0.00015517880159877 NA NA NA hsa-miR-454-3p SMAD4 0.823770738595667 1.30339728183332e-05 -0.31259096016241 0.0041260218763756 miRNAWalker2_validate;miRNATAP -0.142971060915538 3.66752682114237e-05 NA NA NA hsa-miR-493-5p SMAD4 1.32223598235404 3.01688809960418e-10 -0.31259096016241 0.0041260218763756 mirMAP -0.131182789066324 1.6629001131115e-05 NA NA NA hsa-miR-576-5p SMAD4 0.872721964495849 5.20470410008775e-05 -0.31259096016241 0.0041260218763756 mirMAP -0.132545615190079 1.19500054451055e-05 NA NA NA hsa-miR-589-5p SMAD4 1.20000320800112 1.34209467040505e-13 -0.31259096016241 0.0041260218763756 miRNATAP -0.173827604622692 8.83219082977842e-06 NA NA NA hsa-miR-590-3p SMAD4 0.858742926831233 0.000127281269371976 -0.31259096016241 0.0041260218763756 MirTarget;PITA;miRanda;miRNATAP -0.165912881096076 8.79477809927586e-09 NA NA NA hsa-miR-590-5p SMAD4 0.932604531809045 8.39043954167884e-05 -0.31259096016241 0.0041260218763756 miRanda -0.139556957805371 3.50474082856433e-07 NA NA NA hsa-miR-625-5p SMAD4 0.748754910408313 0.00783938428700196 -0.31259096016241 0.0041260218763756 MirTarget -0.129815030519407 2.91249560415629e-08 NA NA NA hsa-miR-16-5p SMAD5 0.468459442059375 0.02635007201346 0.185272436777386 0.0565853388312257 miRNAWalker2_validate;MirTarget;miRNATAP -0.1815409536762 2.07194190890713e-11 NA NA NA hsa-let-7c-5p SMC1A -0.148489254129201 0.548077841857242 0.607015267748412 2.38660719670757e-08 MirTarget -0.165349210478182 6.85152363290102e-10 NA NA NA hsa-miR-101-3p SMC1A -0.0683272309939689 0.544163124741916 0.607015267748412 2.38660719670757e-08 mirMAP -0.278767569904872 5.98766009194258e-06 NA NA NA hsa-miR-145-5p SMC1A -1.54503595327403 2.65080161523141e-09 0.607015267748412 2.38660719670757e-08 mirMAP -0.155580142029504 2.7392550538575e-10 NA NA NA hsa-miR-195-3p SMC1A -0.694544351365025 0.000214711021317786 0.607015267748412 2.38660719670757e-08 mirMAP -0.200257107280565 1.43756002550453e-08 NA NA NA hsa-miR-218-5p SMC1A -0.615157868107884 0.00447149109697709 0.607015267748412 2.38660719670757e-08 mirMAP -0.183320805671101 1.9016819038519e-09 NA NA NA hsa-miR-23b-3p SMC1A -0.228571473429 0.0553601132069074 0.607015267748412 2.38660719670757e-08 mirMAP -0.148084772180509 0.0113569596643821 NA NA NA hsa-miR-379-5p SMC1A -0.0054376932401361 0.973217626106824 0.607015267748412 2.38660719670757e-08 mirMAP -0.12051986166235 0.00459001145244883 NA NA NA hsa-miR-127-5p SMC3 0.809791853526294 0.000176206263785639 0.604088545492056 1.38016154612478e-08 MirTarget;miRNATAP -0.113095108893289 0.000201168542686073 NA NA NA hsa-miR-139-5p SMC3 -1.41674256628297 4.51005988644234e-14 0.604088545492056 1.38016154612478e-08 miRanda -0.167017009640691 5.54077342155264e-07 NA NA NA hsa-miR-150-5p SMC3 0.391701745753361 0.166399987744223 0.604088545492056 1.38016154612478e-08 MirTarget -0.126936841321259 3.47409351399469e-08 NA NA NA hsa-miR-28-5p SMC3 -0.22318016376076 0.0194144033008573 0.604088545492056 1.38016154612478e-08 miRanda -0.375886640077693 1.39896586475073e-07 NA NA NA hsa-miR-16-5p SNRK 0.468459442059375 0.02635007201346 -0.440363445705636 2.69716836697876e-05 MirTarget;miRNATAP -0.214020878084447 3.70050796114776e-13 NA NA NA hsa-miR-16-5p SNX21 0.468459442059375 0.02635007201346 -0.540682527205882 1.24300208179664e-05 mirMAP -0.233835653067943 2.78434721476866e-11 NA NA NA hsa-miR-16-5p SOCS2 0.468459442059375 0.02635007201346 -1.10044523318765 6.64329026112842e-10 miRNAWalker2_validate -0.277286662580015 1.21924465976696e-07 NA NA NA hsa-miR-16-5p SOCS5 0.468459442059375 0.02635007201346 0.20644658123199 0.0461514915995933 miRNAWalker2_validate -0.295543885074731 7.31003804452774e-28 NA NA NA hsa-miR-16-5p SOGA3 0.468459442059375 0.02635007201346 -1.45935044862323 6.09769266940826e-06 MirTarget -0.995765975533316 5.55453779556235e-32 NA NA NA hsa-miR-16-5p SON 0.468459442059375 0.02635007201346 0.168487112479211 0.0440632380826114 miRNAWalker2_validate;miRNATAP -0.121628659321569 2.80329302836622e-07 NA NA NA hsa-miR-16-5p SOS2 0.468459442059375 0.02635007201346 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.210957704787092 6.34408939150223e-15 NA NA NA hsa-miR-16-5p SOWAHC 0.468459442059375 0.02635007201346 -0.16935987546375 0.304931832982079 miRNAWalker2_validate;MirTarget;miRNATAP -0.192351121977879 4.91156018830248e-05 NA NA NA hsa-miR-16-5p SOX5 0.468459442059375 0.02635007201346 -1.09083873380211 3.82011335261816e-05 miRNATAP -0.511170637199685 1.05021226374744e-11 NA NA NA hsa-miR-16-5p SOX6 0.468459442059375 0.02635007201346 -1.17584817693337 3.33834806230109e-05 MirTarget;miRNATAP -0.268889728322971 0.0012300768567627 24852767 Aberrant expression level of miR-16 could suppress cell apoptosis while promote growth by regulating RECK and SOX6 which play important roles in the pathogenesis of ESCC esophageal cancer hsa-miR-16-5p SSBP2 0.468459442059375 0.02635007201346 -1.58025310656881 5.21464030760244e-12 MirTarget -0.555032183154066 1.85154933732377e-17 NA NA NA hsa-miR-16-5p SSH1 0.468459442059375 0.02635007201346 0.322029052369087 0.00169313379685513 mirMAP -0.171779509987528 3.3840284371741e-09 NA NA NA hsa-miR-16-5p ST8SIA3 0.468459442059375 0.02635007201346 -2.91558860135036 1.52609950297091e-08 MirTarget -0.876080874307762 5.31405341159744e-09 NA NA NA hsa-miR-125a-3p STAG1 0.0862037949225951 0.688453004025032 0.202753949272334 0.032961732489752 miRanda -0.103450091192067 0.00014578465770801 NA NA NA hsa-miR-140-5p STAG1 0.132398579631585 0.457960134430787 0.202753949272334 0.032961732489752 miRanda -0.134832288642475 3.2427339548462e-05 NA NA NA hsa-miR-26b-5p STAG1 -0.499493687076043 0.0118149973400486 0.202753949272334 0.032961732489752 miRNAWalker2_validate -0.12666404829718 1.15310806331807e-05 NA NA NA hsa-miR-27a-3p STAG1 0.523219911315699 0.000116410279757859 0.202753949272334 0.032961732489752 MirTarget;miRNATAP -0.129378290539044 0.00251561194340801 NA NA NA hsa-miR-27b-3p STAG1 -0.439806942644624 0.000523870009254693 0.202753949272334 0.032961732489752 MirTarget;miRNATAP -0.129696727122296 0.00499438308551064 NA NA NA hsa-miR-28-5p STAG1 -0.22318016376076 0.0194144033008573 0.202753949272334 0.032961732489752 miRanda -0.171658043932526 0.00662768082779601 NA NA NA hsa-miR-30b-5p STAG1 -0.0106833209203501 0.954966272944722 0.202753949272334 0.032961732489752 MirTarget -0.124330676035906 4.79094407619708e-05 NA NA NA hsa-let-7i-3p STAG2 -0.119304729073549 0.624408822918907 0.251647759501321 0.0043814053567223 MirTarget;miRNATAP -0.159946785240492 4.18470655225561e-14 NA NA NA hsa-miR-195-3p STAG2 -0.694544351365025 0.000214711021317786 0.251647759501321 0.0043814053567223 MirTarget;miRNATAP -0.114257638977713 5.75755080206758e-05 NA NA NA hsa-miR-29a-3p STAG2 -0.235052170104117 0.138527567930958 0.251647759501321 0.0043814053567223 MirTarget;miRNATAP -0.108170691603365 0.0015963074359191 NA NA NA hsa-miR-29c-3p STAG2 -1.34143813218298 2.77493790306384e-12 0.251647759501321 0.0043814053567223 MirTarget;miRNATAP -0.15104211136793 1.0406373842133e-08 NA NA NA hsa-miR-30a-5p STAG2 -0.742755040631906 3.79943871404435e-05 0.251647759501321 0.0043814053567223 MirTarget;mirMAP;miRNATAP -0.130420125878043 8.78848856221503e-06 NA NA NA hsa-miR-495-3p STAG2 -0.024887553302567 0.897251687801771 0.251647759501321 0.0043814053567223 MirTarget -0.160299936842139 5.41318391178276e-09 NA NA NA hsa-miR-16-5p STK33 0.468459442059375 0.02635007201346 -0.92864452301099 0.00657026101364563 miRNAWalker2_validate;MirTarget;miRNATAP -0.526616351914148 7.02013541952796e-08 NA NA NA hsa-miR-16-5p STOX2 0.468459442059375 0.02635007201346 -1.38885793271292 7.68761182671221e-06 MirTarget -0.486897992202117 5.8484179083031e-08 NA NA NA hsa-miR-16-5p STX17 0.468459442059375 0.02635007201346 -0.168614977727771 0.0370678702778951 MirTarget -0.13613563005823 1.9103521649482e-09 NA NA NA hsa-miR-16-5p STXBP1 0.468459442059375 0.02635007201346 0.154311510666179 0.485187424704128 MirTarget;miRNATAP -0.187717269903893 0.00333917465408358 NA NA NA hsa-miR-16-5p STYX 0.468459442059375 0.02635007201346 -0.0447871564829079 0.614114876390358 miRNATAP -0.13799633270026 3.29958852908188e-08 NA NA NA hsa-miR-16-5p SWAP70 0.468459442059375 0.02635007201346 -0.0283444386061209 0.810845764431306 MirTarget -0.112040853602413 0.00100186385760347 NA NA NA hsa-miR-16-5p SYDE1 0.468459442059375 0.02635007201346 -0.0640700013959519 0.734826242563291 miRNATAP -0.394459563439924 4.46525828714196e-14 NA NA NA hsa-miR-16-5p SYDE2 0.468459442059375 0.02635007201346 -0.299681486604406 0.195483256134359 miRNATAP -0.667094599743133 2.77408708586741e-28 NA NA NA hsa-miR-16-5p SYNDIG1 0.468459442059375 0.02635007201346 1.56178434055742 5.39669156246686e-07 MirTarget;miRNATAP -0.231630014667531 0.0123191475488677 NA NA NA hsa-miR-16-5p SYNE1 0.468459442059375 0.02635007201346 -0.737828565382011 0.00316151426540844 MirTarget -0.595054740772565 3.87482087339147e-18 NA NA NA hsa-miR-16-5p SYNJ1 0.468459442059375 0.02635007201346 0.099773753433825 0.303608235961315 miRNAWalker2_validate;MirTarget;miRNATAP -0.140373130908645 3.14582003245791e-07 NA NA NA hsa-miR-16-5p SYNPO 0.468459442059375 0.02635007201346 -0.336304575074278 0.0837448668188425 mirMAP -0.36947403998089 1.13858932008819e-11 NA NA NA hsa-miR-16-5p SYT11 0.468459442059375 0.02635007201346 -0.0332651006696336 0.879791327587014 miRNAWalker2_validate -0.501253112748393 7.50783085938362e-17 NA NA NA hsa-miR-16-5p SYT3 0.468459442059375 0.02635007201346 0.198584605183963 0.586926830034396 miRNATAP -0.537849664532372 2.34826281848589e-07 NA NA NA hsa-miR-16-5p SYT4 0.468459442059375 0.02635007201346 -3.20681967154073 1.00295168545729e-07 MirTarget -0.863300323991926 9.97857739657678e-07 NA NA NA hsa-miR-16-5p TACC1 0.468459442059375 0.02635007201346 -0.361657767484704 0.0540556103390073 MirTarget -0.497095187283969 3.61235549189228e-23 NA NA NA hsa-miR-16-5p TAOK1 0.468459442059375 0.02635007201346 0.34222374126551 0.000498972568442839 MirTarget;miRNATAP -0.176537749206081 1.98458293351823e-10 NA NA NA hsa-miR-16-5p TBC1D20 0.468459442059375 0.02635007201346 -0.141869643616188 0.0683752364327144 MirTarget -0.157063372582471 2.2970399144164e-13 NA NA NA hsa-miR-16-5p TBRG1 0.468459442059375 0.02635007201346 -0.0707275916682448 0.373239777663103 miRNAWalker2_validate -0.108957715680883 1.20267378226415e-06 NA NA NA hsa-miR-16-5p TCEA2 0.468459442059375 0.02635007201346 -0.653060587847677 0.00171167383430329 mirMAP -0.228898509755977 0.000152485561389503 NA NA NA hsa-miR-16-5p TCFL5 0.468459442059375 0.02635007201346 0.393616939437025 0.00234199758038093 miRNAWalker2_validate -0.103945982762774 0.00578738868023131 NA NA NA hsa-miR-16-5p TES 0.468459442059375 0.02635007201346 -0.348224082593956 0.00638545187280882 miRNAWalker2_validate -0.226707354868263 3.07666264014068e-10 NA NA NA hsa-miR-16-5p TEX15 0.468459442059375 0.02635007201346 -2.24520433024939 0.0001512669775356 miRNAWalker2_validate -0.686429554328572 7.07471844465324e-05 NA NA NA hsa-miR-28-5p TFDP1 -0.22318016376076 0.0194144033008573 0.632044222109323 9.24777779219588e-08 miRanda -0.401982633123196 4.05799063181099e-07 NA NA NA hsa-miR-30a-3p TFDP1 -1.27950866170419 4.33230022379782e-09 0.632044222109323 9.24777779219588e-08 MirTarget;miRNATAP -0.257306219791297 1.57016092408736e-16 NA NA NA hsa-miR-30a-5p TFDP1 -0.742755040631906 3.79943871404435e-05 0.632044222109323 9.24777779219588e-08 MirTarget;miRNATAP -0.331137751937732 4.73078178503692e-18 NA NA NA hsa-let-7a-3p TFDP2 0.283468597868531 0.127007787220086 -0.160784627018407 0.291450213121909 mirMAP -0.385534399350276 6.43268574129498e-16 NA NA NA hsa-let-7b-3p TFDP2 0.377956364821509 0.0061730103051373 -0.160784627018407 0.291450213121909 mirMAP -0.42993341021734 7.15808136113444e-11 NA NA NA hsa-let-7f-1-3p TFDP2 1.09636075438131 3.42037366931931e-10 -0.160784627018407 0.291450213121909 mirMAP -0.31725255378317 2.73691972642375e-10 NA NA NA hsa-miR-125a-3p TFDP2 0.0862037949225951 0.688453004025032 -0.160784627018407 0.291450213121909 mirMAP -0.204947464898415 2.34271363963385e-06 NA NA NA hsa-miR-126-5p TFDP2 0.450893496822779 0.0112966412858755 -0.160784627018407 0.291450213121909 mirMAP -0.340788643609999 1.60531452957541e-11 NA NA NA hsa-miR-127-5p TFDP2 0.809791853526294 0.000176206263785639 -0.160784627018407 0.291450213121909 mirMAP -0.203016310958754 1.38858619159234e-06 NA NA NA hsa-miR-1271-5p TFDP2 0.174238075093354 0.430890829818199 -0.160784627018407 0.291450213121909 MirTarget;mirMAP -0.13854758456943 0.00137611215266843 NA NA NA hsa-miR-1301-3p TFDP2 1.62626930622185 2.81303026159352e-11 -0.160784627018407 0.291450213121909 MirTarget -0.178800893865776 6.8958535180124e-07 NA NA NA hsa-miR-130b-5p TFDP2 1.47709791778827 1.34679413565661e-06 -0.160784627018407 0.291450213121909 mirMAP -0.255472849731992 1.31874553549631e-19 NA NA NA hsa-miR-132-3p TFDP2 0.615446256559387 1.70100472454261e-06 -0.160784627018407 0.291450213121909 mirMAP -0.176768923253055 0.0146954706463492 NA NA NA hsa-miR-135b-5p TFDP2 2.80066701698235 2.12546333413447e-11 -0.160784627018407 0.291450213121909 mirMAP -0.134937816730586 4.69084955548852e-10 NA NA NA hsa-miR-141-3p TFDP2 1.76274853293464 9.99331900755725e-07 -0.160784627018407 0.291450213121909 miRNAWalker2_validate;MirTarget -0.204741781523884 5.07065935772983e-18 NA NA NA hsa-miR-144-3p TFDP2 -1.37061426401952 5.85913017989725e-05 -0.160784627018407 0.291450213121909 mirMAP -0.157691800811009 2.95959157276215e-09 NA NA NA hsa-miR-146a-5p TFDP2 0.801543189433048 0.00411744525146003 -0.160784627018407 0.291450213121909 MirTarget -0.235343109746078 9.44710762533126e-14 NA NA NA hsa-miR-146b-5p TFDP2 2.23105707690238 3.83997814011313e-23 -0.160784627018407 0.291450213121909 MirTarget -0.203833158960925 3.85330635310907e-08 NA NA NA hsa-miR-148a-3p TFDP2 -0.18108394434325 0.495345303586758 -0.160784627018407 0.291450213121909 MirTarget -0.24524300452186 2.74759891554777e-13 NA NA NA hsa-miR-148b-3p TFDP2 0.719517328390822 3.51245964668412e-05 -0.160784627018407 0.291450213121909 MirTarget -0.41645782366205 1.04711186898025e-16 NA NA NA hsa-miR-155-5p TFDP2 0.708423342476697 0.00686702252429413 -0.160784627018407 0.291450213121909 miRNATAP -0.279584598803917 4.39423015684543e-17 NA NA NA hsa-miR-15a-5p TFDP2 1.07800995489566 4.32072598796529e-10 -0.160784627018407 0.291450213121909 MirTarget -0.286024179492344 2.41513071025192e-08 NA NA NA hsa-miR-15b-5p TFDP2 0.637819606405168 0.000580041575431604 -0.160784627018407 0.291450213121909 MirTarget;mirMAP -0.335381827455406 3.1579710161647e-12 NA NA NA hsa-miR-16-1-3p TFDP2 1.23864765632542 1.24544799589822e-08 -0.160784627018407 0.291450213121909 mirMAP -0.201997445237417 1.85785540511798e-06 NA NA NA hsa-miR-16-2-3p TFDP2 0.869267463341732 0.000785361809327569 -0.160784627018407 0.291450213121909 mirMAP -0.267118532683482 2.82760558813639e-15 NA NA NA hsa-miR-16-5p TFDP2 0.468459442059375 0.02635007201346 -0.160784627018407 0.291450213121909 MirTarget;mirMAP -0.386694300759655 3.12973539447999e-21 NA NA NA hsa-miR-17-3p TFDP2 1.37838995268509 5.00444740462873e-13 -0.160784627018407 0.291450213121909 MirTarget -0.152549651196562 0.00106451756295844 NA NA NA hsa-miR-182-5p TFDP2 1.73826081735237 5.69817940588551e-09 -0.160784627018407 0.291450213121909 mirMAP -0.210774406895774 3.19640504391312e-13 NA NA NA hsa-miR-186-5p TFDP2 0.35512789129261 0.0196931838168008 -0.160784627018407 0.291450213121909 MirTarget;mirMAP -0.441189732677378 6.88782432276273e-14 NA NA NA hsa-miR-188-5p TFDP2 1.57437249320621 2.78824007819973e-08 -0.160784627018407 0.291450213121909 mirMAP -0.18189899668272 3.10566933816953e-08 NA NA NA hsa-miR-192-3p TFDP2 1.78627547479709 3.23498378613139e-06 -0.160784627018407 0.291450213121909 mirMAP -0.143030711125747 5.14170245691884e-10 NA NA NA hsa-miR-193b-5p TFDP2 -0.285781399446643 0.232222694151592 -0.160784627018407 0.291450213121909 mirMAP -0.157665480126082 4.56022677371667e-05 NA NA NA hsa-miR-194-3p TFDP2 1.91477879150304 2.49480074178753e-07 -0.160784627018407 0.291450213121909 mirMAP -0.109244432279301 1.13218395148428e-05 NA NA NA hsa-miR-19a-3p TFDP2 1.71062381299889 1.72281025366819e-11 -0.160784627018407 0.291450213121909 MirTarget -0.163727881841445 2.27726951302219e-06 NA NA NA hsa-miR-19b-3p TFDP2 0.936987029203338 9.28141970787798e-06 -0.160784627018407 0.291450213121909 MirTarget -0.232959238367236 4.18375332589738e-08 NA NA NA hsa-miR-200a-3p TFDP2 2.02394729844446 2.21240501925011e-08 -0.160784627018407 0.291450213121909 MirTarget -0.172157284299519 6.00295058912596e-13 NA NA NA hsa-miR-203a-3p TFDP2 0.986535065247669 0.00954714606545506 -0.160784627018407 0.291450213121909 MirTarget -0.16425903929959 1.73259067047762e-12 NA NA NA hsa-miR-212-3p TFDP2 0.810640598956005 2.08058512206955e-06 -0.160784627018407 0.291450213121909 mirMAP -0.303149101550765 7.97279566495437e-09 NA NA NA hsa-miR-22-5p TFDP2 0.668839167786886 0.00102248931590479 -0.160784627018407 0.291450213121909 mirMAP -0.32072027611078 1.68925770678844e-13 NA NA NA hsa-miR-2355-5p TFDP2 0.624463693002283 6.00185219101058e-05 -0.160784627018407 0.291450213121909 mirMAP -0.136682238576984 0.0222221611274934 NA NA NA hsa-miR-23a-3p TFDP2 0.694558223570443 8.99413995422816e-10 -0.160784627018407 0.291450213121909 mirMAP -0.283614435084363 0.000476421688951947 NA NA NA hsa-miR-25-3p TFDP2 0.948739680210032 3.62304579611938e-09 -0.160784627018407 0.291450213121909 MirTarget;miRNATAP -0.29052729418849 1.74020627698945e-07 NA NA NA hsa-miR-27a-3p TFDP2 0.523219911315699 0.000116410279757859 -0.160784627018407 0.291450213121909 mirMAP -0.538156673074338 1.32927805271545e-16 NA NA NA hsa-miR-27a-5p TFDP2 0.59763448976729 0.00736257811879899 -0.160784627018407 0.291450213121909 mirMAP -0.263997664873145 5.19621787918669e-11 NA NA NA hsa-miR-299-5p TFDP2 -0.162422032147768 0.435278723340297 -0.160784627018407 0.291450213121909 mirMAP -0.207828065071993 3.27687891166572e-06 NA NA NA hsa-miR-29a-3p TFDP2 -0.235052170104117 0.138527567930958 -0.160784627018407 0.291450213121909 mirMAP -0.41463681087399 2.75863114220546e-13 NA NA NA hsa-miR-29b-1-5p TFDP2 1.27585983480192 1.70509960024426e-05 -0.160784627018407 0.291450213121909 mirMAP -0.200336342304898 2.17936293658511e-11 NA NA NA hsa-miR-29b-3p TFDP2 0.0225365195743876 0.914313337784307 -0.160784627018407 0.291450213121909 mirMAP -0.310555147441026 3.87434454958465e-13 NA NA NA hsa-miR-29c-3p TFDP2 -1.34143813218298 2.77493790306384e-12 -0.160784627018407 0.291450213121909 mirMAP -0.143549321148324 0.00202843683336931 NA NA NA hsa-miR-3065-3p TFDP2 -0.00685158653722073 0.979081293235379 -0.160784627018407 0.291450213121909 MirTarget -0.116481121129183 0.00104195662713025 NA NA NA hsa-miR-30b-3p TFDP2 0.252088263642787 0.216818735503048 -0.160784627018407 0.291450213121909 MirTarget -0.173468947086601 0.000144581600385187 NA NA NA hsa-miR-32-5p TFDP2 0.425717775201634 0.0402079308210921 -0.160784627018407 0.291450213121909 MirTarget;mirMAP;miRNATAP -0.347758704088703 2.56630055045585e-16 NA NA NA hsa-miR-320a TFDP2 0.451741078692272 0.00893327237386749 -0.160784627018407 0.291450213121909 mirMAP -0.201526612182289 0.000173558281192814 NA NA NA hsa-miR-320b TFDP2 1.21733873788625 7.99882585998487e-07 -0.160784627018407 0.291450213121909 mirMAP -0.217977721539372 1.29942444994093e-09 NA NA NA hsa-miR-326 TFDP2 -0.552187708067123 0.039648668341622 -0.160784627018407 0.291450213121909 mirMAP -0.173105761386323 3.61721463359544e-07 NA NA NA hsa-miR-331-3p TFDP2 0.818192524829557 0.000359485856225569 -0.160784627018407 0.291450213121909 mirMAP -0.240450504787001 7.55768411808626e-10 NA NA NA hsa-miR-335-5p TFDP2 0.576542642348884 0.01886326850059 -0.160784627018407 0.291450213121909 miRNATAP -0.147032208213234 9.39977007600024e-05 NA NA NA hsa-miR-33a-3p TFDP2 0.21453033253985 0.371591474252951 -0.160784627018407 0.291450213121909 mirMAP -0.237158419797996 1.9348062516485e-09 NA NA NA hsa-miR-33a-5p TFDP2 0.372183130885047 0.335617783855811 -0.160784627018407 0.291450213121909 MirTarget -0.142924494228888 8.7411381657708e-10 NA NA NA hsa-miR-340-5p TFDP2 0.344103676703511 0.0160638942614091 -0.160784627018407 0.291450213121909 mirMAP -0.184242903658204 0.00511072386375019 NA NA NA hsa-miR-342-3p TFDP2 0.235422340773149 0.290471946350276 -0.160784627018407 0.291450213121909 miRNATAP -0.234651938976029 9.47200279162572e-09 NA NA NA hsa-miR-345-5p TFDP2 0.906439112334506 0.00375888297100119 -0.160784627018407 0.291450213121909 MirTarget -0.211759247456673 1.43566690950122e-13 NA NA NA hsa-miR-34a-5p TFDP2 0.691825068787607 0.00069818668499891 -0.160784627018407 0.291450213121909 miRNATAP -0.320531930489368 1.48049204814634e-13 NA NA NA hsa-miR-3607-3p TFDP2 0.479939234340415 0.251616873367277 -0.160784627018407 0.291450213121909 MirTarget -0.127788046626581 9.87620368341735e-09 NA NA NA hsa-miR-3614-5p TFDP2 0.288051497709626 0.339707047011435 -0.160784627018407 0.291450213121909 mirMAP;miRNATAP -0.256362971778822 3.14723411097278e-15 NA NA NA hsa-miR-362-3p TFDP2 0.994614346444282 4.39793878186399e-05 -0.160784627018407 0.291450213121909 mirMAP -0.211601860671116 2.88068600893381e-08 NA NA NA hsa-miR-365a-3p TFDP2 -0.801671336684825 1.28258342849568e-06 -0.160784627018407 0.291450213121909 mirMAP -0.161636885271459 0.00359111090817336 NA NA NA hsa-miR-378a-5p TFDP2 -0.684033095877066 0.000471076679969606 -0.160784627018407 0.291450213121909 mirMAP -0.162320978289374 0.000568763041976714 NA NA NA hsa-miR-421 TFDP2 1.26653675546617 2.35180826009926e-08 -0.160784627018407 0.291450213121909 mirMAP -0.193601742173737 1.12130896744825e-06 NA NA NA hsa-miR-424-5p TFDP2 0.956135912596328 0.00035164943928494 -0.160784627018407 0.291450213121909 MirTarget;mirMAP -0.258533715052099 2.43972162573458e-15 NA NA NA hsa-miR-429 TFDP2 1.58250682050303 4.75828087352234e-05 -0.160784627018407 0.291450213121909 miRNATAP -0.173802056639153 2.10243293245954e-14 NA NA NA hsa-miR-455-3p TFDP2 1.12209231899143 0.00131487017648489 -0.160784627018407 0.291450213121909 mirMAP -0.194655140265176 8.01396787935218e-15 NA NA NA hsa-miR-495-3p TFDP2 -0.024887553302567 0.897251687801771 -0.160784627018407 0.291450213121909 mirMAP -0.14486652536238 0.00283018718730074 NA NA NA hsa-miR-501-3p TFDP2 1.88467797720099 9.65178855450719e-15 -0.160784627018407 0.291450213121909 MirTarget;TargetScan;miRNATAP -0.226864412027519 1.09440168236889e-10 NA NA NA hsa-miR-502-3p TFDP2 0.989057260587538 3.37032335853725e-07 -0.160784627018407 0.291450213121909 MirTarget;miRNATAP -0.31489108953261 3.85683017603513e-12 NA NA NA hsa-miR-505-3p TFDP2 0.68973424635459 0.00225185811813183 -0.160784627018407 0.291450213121909 mirMAP -0.273402644114668 4.17567278613578e-12 NA NA NA hsa-miR-532-5p TFDP2 1.45407925817457 1.88450871132345e-14 -0.160784627018407 0.291450213121909 mirMAP -0.151139212116934 0.00117238310982396 NA NA NA hsa-miR-542-3p TFDP2 1.12416854979951 1.02649534578738e-12 -0.160784627018407 0.291450213121909 mirMAP -0.145516204019932 0.0106518787065288 NA NA NA hsa-miR-584-5p TFDP2 1.67982799803889 6.57055559274014e-09 -0.160784627018407 0.291450213121909 mirMAP -0.125963955832544 4.46672365453556e-05 NA NA NA hsa-miR-589-5p TFDP2 1.20000320800112 1.34209467040505e-13 -0.160784627018407 0.291450213121909 mirMAP -0.226063568598971 3.50286007841554e-05 NA NA NA hsa-miR-590-3p TFDP2 0.858742926831233 0.000127281269371976 -0.160784627018407 0.291450213121909 mirMAP -0.341507424320797 7.91735582584343e-19 NA NA NA hsa-miR-629-3p TFDP2 0.597278340934362 0.0508108703940013 -0.160784627018407 0.291450213121909 MirTarget -0.241920207202797 4.61951693195224e-15 NA NA NA hsa-miR-654-3p TFDP2 -0.141140644392039 0.545807044192286 -0.160784627018407 0.291450213121909 mirMAP -0.168242025388353 2.05533196784607e-05 NA NA NA hsa-miR-660-5p TFDP2 1.23607536548029 2.61099214897472e-10 -0.160784627018407 0.291450213121909 mirMAP -0.101568398929739 0.0279702572240928 NA NA NA hsa-miR-7-1-3p TFDP2 0.94398354303717 7.5771319809992e-05 -0.160784627018407 0.291450213121909 mirMAP -0.237073705514623 2.18767963676322e-10 NA NA NA hsa-miR-92a-3p TFDP2 1.06124545165614 6.51550014372282e-08 -0.160784627018407 0.291450213121909 MirTarget;miRNATAP -0.16901051013162 0.000246720095864777 NA NA NA hsa-miR-92b-3p TFDP2 1.10163066523605 4.43024463410466e-10 -0.160784627018407 0.291450213121909 MirTarget;miRNATAP -0.104692177784557 0.0416486685722231 NA NA NA hsa-miR-93-3p TFDP2 1.18510939268904 1.19856269043125e-06 -0.160784627018407 0.291450213121909 mirMAP -0.213659211973567 4.45554270401124e-09 NA NA NA hsa-miR-96-5p TFDP2 1.44821155854693 6.56312590328933e-06 -0.160784627018407 0.291450213121909 MirTarget;TargetScan;mirMAP -0.149563216439745 5.05679561693024e-07 NA NA NA hsa-miR-16-5p TFPI 0.468459442059375 0.02635007201346 -0.0903165752589947 0.661792991177754 miRNAWalker2_validate -0.261079099581023 9.96681371774086e-06 NA NA NA hsa-miR-29b-3p TGFB1 0.0225365195743876 0.914313337784307 0.00235082696023081 0.988118623952536 miRTarBase -0.103287725377405 0.025660867633912 NA NA NA hsa-miR-744-5p TGFB1 0.734924181943417 2.06706878377701e-05 0.00235082696023081 0.988118623952536 miRNAWalker2_validate;miRNATAP -0.195402458196426 0.000389074670739643 NA NA NA hsa-let-7a-3p TGFB2 0.283468597868531 0.127007787220086 0.888965225928418 0.000136671877757956 miRNATAP -0.305491278527153 8.12073923341399e-05 NA NA NA hsa-let-7b-3p TGFB2 0.377956364821509 0.0061730103051373 0.888965225928418 0.000136671877757956 miRNATAP -0.269835433091865 0.0108034259978508 NA NA NA hsa-miR-107 TGFB2 0.85152957824299 1.22369651446858e-11 0.888965225928418 0.000136671877757956 miRanda -0.333664472870841 0.00298378306905984 NA NA NA hsa-miR-126-5p TGFB2 0.450893496822779 0.0112966412858755 0.888965225928418 0.000136671877757956 mirMAP -0.328549035720951 4.58252447507491e-05 NA NA NA hsa-miR-130b-3p TGFB2 1.29757792612022 1.70655148591568e-06 0.888965225928418 0.000136671877757956 MirTarget;miRNATAP -0.227311724123213 1.03078119894332e-05 NA NA NA hsa-miR-141-3p TGFB2 1.76274853293464 9.99331900755725e-07 0.888965225928418 0.000136671877757956 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.208320376132691 5.25572828490613e-08 NA NA NA hsa-miR-142-3p TGFB2 1.80134804047727 3.87649742898476e-07 0.888965225928418 0.000136671877757956 miRNATAP -0.155076496052334 7.9930637506259e-05 NA NA NA hsa-miR-142-5p TGFB2 1.08445947321046 0.000126372881543671 0.888965225928418 0.000136671877757956 mirMAP -0.265448967517965 7.31357887663622e-08 NA NA NA hsa-miR-148a-3p TGFB2 -0.18108394434325 0.495345303586758 0.888965225928418 0.000136671877757956 MirTarget;miRNATAP -0.321912545442852 1.13696413892015e-09 NA NA NA hsa-miR-148b-3p TGFB2 0.719517328390822 3.51245964668412e-05 0.888965225928418 0.000136671877757956 MirTarget -0.256856391465243 0.00179040778577862 NA NA NA hsa-miR-186-5p TGFB2 0.35512789129261 0.0196931838168008 0.888965225928418 0.000136671877757956 mirMAP -0.30258934639006 0.00151449292297366 NA NA NA hsa-miR-200a-3p TGFB2 2.02394729844446 2.21240501925011e-08 0.888965225928418 0.000136671877757956 MirTarget;miRNATAP -0.189993396216634 5.87055843170913e-07 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 0.986535065247669 0.00954714606545506 0.888965225928418 0.000136671877757956 MirTarget -0.193530437543144 1.53991515981722e-07 NA NA NA hsa-miR-29a-3p TGFB2 -0.235052170104117 0.138527567930958 0.888965225928418 0.000136671877757956 MirTarget;miRNATAP -0.581393089707526 6.22664631563867e-11 NA NA NA hsa-miR-29b-3p TGFB2 0.0225365195743876 0.914313337784307 0.888965225928418 0.000136671877757956 miRTarBase;MirTarget;miRNATAP -0.395329278956424 4.74245317189332e-09 NA NA NA hsa-miR-29c-3p TGFB2 -1.34143813218298 2.77493790306384e-12 0.888965225928418 0.000136671877757956 MirTarget;miRNATAP -0.325446016179042 5.17187275890528e-06 NA NA NA hsa-miR-320b TGFB2 1.21733873788625 7.99882585998487e-07 0.888965225928418 0.000136671877757956 miRanda -0.146605701272824 0.01057269593441 NA NA NA hsa-miR-324-5p TGFB2 0.800946351685734 0.00101337664367375 0.888965225928418 0.000136671877757956 miRanda -0.131823809791165 0.0251637341961129 NA NA NA hsa-miR-326 TGFB2 -0.552187708067123 0.039648668341622 0.888965225928418 0.000136671877757956 miRanda -0.194301814390441 0.000275291049156306 NA NA NA hsa-miR-330-3p TGFB2 0.391166748754241 0.0581284813543685 0.888965225928418 0.000136671877757956 miRNATAP -0.22652076165777 0.00172609016103779 NA NA NA hsa-miR-330-5p TGFB2 0.621676971901542 0.00233177378595631 0.888965225928418 0.000136671877757956 miRanda -0.300673618978389 1.60017818502782e-05 NA NA NA hsa-miR-331-5p TGFB2 0.703863188605486 4.25406757208802e-05 0.888965225928418 0.000136671877757956 miRNATAP -0.180691839447122 0.0314709567847566 NA NA NA hsa-miR-33a-3p TGFB2 0.21453033253985 0.371591474252951 0.888965225928418 0.000136671877757956 MirTarget;mirMAP -0.33891121465919 3.80400125326151e-08 NA NA NA hsa-miR-362-3p TGFB2 0.994614346444282 4.39793878186399e-05 0.888965225928418 0.000136671877757956 miRanda -0.286945914928026 1.46959052957297e-06 NA NA NA hsa-miR-362-5p TGFB2 1.45312548529729 9.37098891085093e-09 0.888965225928418 0.000136671877757956 MirTarget -0.129357132925511 0.0197300522560473 NA NA NA hsa-miR-374a-5p TGFB2 0.239597788731458 0.0202963000797544 0.888965225928418 0.000136671877757956 mirMAP -0.315963843466741 0.0292090843919445 NA NA NA hsa-miR-429 TGFB2 1.58250682050303 4.75828087352234e-05 0.888965225928418 0.000136671877757956 miRNATAP -0.182532900629742 5.23716879318949e-07 NA NA NA hsa-miR-454-3p TGFB2 0.823770738595667 1.30339728183332e-05 0.888965225928418 0.000136671877757956 MirTarget;miRNATAP -0.173969419444153 0.0215694462324379 NA NA NA hsa-miR-500a-5p TGFB2 1.33126717816499 3.1497328652235e-07 0.888965225928418 0.000136671877757956 mirMAP -0.189857917811221 0.000428476372408117 NA NA NA hsa-miR-500b-5p TGFB2 1.32865046193865 3.31620679475787e-07 0.888965225928418 0.000136671877757956 MirTarget -0.189721947976981 0.000433586583443196 NA NA NA hsa-miR-589-3p TGFB2 1.00357906465313 8.20399071001461e-05 0.888965225928418 0.000136671877757956 MirTarget -0.200652593538218 0.000642013633658382 NA NA NA hsa-miR-590-3p TGFB2 0.858742926831233 0.000127281269371976 0.888965225928418 0.000136671877757956 mirMAP -0.301254523781146 1.69747636312579e-06 NA NA NA hsa-miR-590-5p TGFB2 0.932604531809045 8.39043954167884e-05 0.888965225928418 0.000136671877757956 miRanda;miRNATAP -0.24702110908256 3.51880355716329e-05 NA NA NA hsa-miR-7-5p TGFB2 1.20202447072014 0.000123775346787165 0.888965225928418 0.000136671877757956 MirTarget -0.253936538411322 9.60590106987094e-08 NA NA NA hsa-let-7a-3p TGFB3 0.283468597868531 0.127007787220086 0.473488071545503 0.0435617216315732 MirTarget -0.355645142948598 3.68061501504744e-06 NA NA NA hsa-let-7b-3p TGFB3 0.377956364821509 0.0061730103051373 0.473488071545503 0.0435617216315732 MirTarget -0.295879876739272 0.00498500962259216 NA NA NA hsa-let-7f-1-3p TGFB3 1.09636075438131 3.42037366931931e-10 0.473488071545503 0.0435617216315732 MirTarget -0.332548850162871 2.775882919758e-05 NA NA NA hsa-miR-151a-5p TGFB3 0.897578755117332 4.82602190477219e-06 0.473488071545503 0.0435617216315732 MirTarget -0.428709461065634 1.06936455182509e-09 NA NA NA hsa-miR-26b-3p TGFB3 0.312629571566403 0.245454206213408 0.473488071545503 0.0435617216315732 MirTarget -0.22812847650541 1.58139524603585e-05 NA NA NA hsa-miR-29a-3p TGFB3 -0.235052170104117 0.138527567930958 0.473488071545503 0.0435617216315732 miRNAWalker2_validate -0.296802899669284 0.00115645844388188 NA NA NA hsa-miR-29b-3p TGFB3 0.0225365195743876 0.914313337784307 0.473488071545503 0.0435617216315732 miRTarBase -0.38037305055259 1.69980032851481e-08 NA NA NA hsa-miR-338-5p TGFB3 -0.420442436641152 0.0583175290447746 0.473488071545503 0.0435617216315732 PITA -0.247841705819985 0.000121188040328557 NA NA NA hsa-miR-590-3p TGFB3 0.858742926831233 0.000127281269371976 0.473488071545503 0.0435617216315732 miRanda -0.352078733171506 1.50707419898057e-08 NA NA NA hsa-miR-629-3p TGFB3 0.597278340934362 0.0508108703940013 0.473488071545503 0.0435617216315732 MirTarget -0.277974171747757 1.44667913345825e-08 NA NA NA hsa-miR-16-5p TGFBI 0.468459442059375 0.02635007201346 0.672244292621488 0.00218044324355788 miRNAWalker2_validate -0.261663207988355 3.7773486494115e-05 NA NA NA hsa-miR-16-5p TGFBR3 0.468459442059375 0.02635007201346 -1.17329353105567 5.76332601597347e-06 MirTarget;miRNATAP -0.707341422014863 5.54612652027264e-24 NA NA NA hsa-miR-16-5p THRB 0.468459442059375 0.02635007201346 -1.11745660181354 0.00039648730743052 MirTarget -0.571949367547602 1.7669545460057e-10 NA NA NA hsa-miR-16-5p THSD4 0.468459442059375 0.02635007201346 -1.40005104343222 1.03135805453461e-07 MirTarget -0.425965601079675 2.62505807212949e-08 NA NA NA hsa-miR-16-5p TIA1 0.468459442059375 0.02635007201346 0.551692210838088 1.20297999532581e-05 miRNAWalker2_validate -0.131103785873264 0.000376002250332555 NA NA NA hsa-miR-16-5p TIMP3 0.468459442059375 0.02635007201346 -0.545766258963537 0.0230696906023966 miRNAWalker2_validate -0.509797414891497 2.01308023758019e-14 NA NA NA hsa-miR-16-5p TLE4 0.468459442059375 0.02635007201346 -1.15702818127241 1.2267818242402e-11 miRNAWalker2_validate -0.324285204896589 8.05086119284953e-11 NA NA NA hsa-miR-16-5p TLK1 0.468459442059375 0.02635007201346 -0.0930732141591468 0.237909428876318 miRNAWalker2_validate;MirTarget;miRNATAP -0.175316917223304 2.64724180646716e-16 NA NA NA hsa-miR-16-5p TLL1 0.468459442059375 0.02635007201346 -1.19495000359464 2.51143775869264e-05 miRNATAP -0.57485338487228 7.47291112967837e-13 NA NA NA hsa-miR-16-5p TMCC1 0.468459442059375 0.02635007201346 0.246634162901872 0.00839217828410787 miRNAWalker2_validate;miRNATAP -0.159479683110072 1.43643403384868e-09 NA NA NA hsa-miR-16-5p TMEM100 0.468459442059375 0.02635007201346 -3.27195385316868 6.21442061957714e-15 miRNAWalker2_validate;MirTarget -0.965461946344249 2.80321689302258e-15 NA NA NA hsa-miR-16-5p TMEM109 0.468459442059375 0.02635007201346 -0.278587947088214 0.00410264157255814 miRNAWalker2_validate -0.117512799040572 2.49163302325205e-05 NA NA NA hsa-miR-16-5p TMEM245 0.468459442059375 0.02635007201346 -0.242721302151875 0.0930172579576728 miRNAWalker2_validate;miRNATAP -0.416614766314106 2.19205992663311e-28 NA NA NA hsa-miR-16-5p TMEM43 0.468459442059375 0.02635007201346 0.0145253608400795 0.898804510538956 miRNAWalker2_validate;MirTarget -0.321216235555236 4.65310853296432e-27 NA NA NA hsa-miR-16-5p TMEM55A 0.468459442059375 0.02635007201346 -0.621767832522187 0.00323252275135545 MirTarget -0.570152143900463 6.06405381696272e-24 NA NA NA hsa-miR-16-5p TMTC3 0.468459442059375 0.02635007201346 0.122636432015445 0.221891077515614 miRNAWalker2_validate -0.172882172886055 7.96401989929384e-10 NA NA NA hsa-miR-16-5p TNFAIP8L3 0.468459442059375 0.02635007201346 -1.60070797435006 5.72310426720932e-08 MirTarget -0.664875217965818 1.51366749504143e-15 NA NA NA hsa-miR-16-5p TNRC6B 0.468459442059375 0.02635007201346 0.0200605311980917 0.853993906874431 miRNAWalker2_validate;miRNATAP -0.212229664546089 2.13415167233416e-12 NA NA NA hsa-miR-16-5p TOM1L2 0.468459442059375 0.02635007201346 -0.994181490940386 3.17616240628865e-12 mirMAP -0.26669278539097 1.78009923342539e-10 NA NA NA hsa-miR-125a-5p TP53 -0.261743402170195 0.116107665196876 0.511940387522054 0.00485905823274999 miRNAWalker2_validate;miRTarBase;miRanda -0.244153419981785 0.000286434605400778 26389681;21777146;23079745 Mechanistically inactivation of miR-125a during cervical carcinogenesis was caused by HPV suppression of p53 expression;In addition wild-type p53 mRNA and protein expression was increased by hsa-miR-125a-5p overexpression; Moreover blocking wild-type p53 attenuated the effect of hsa-miR-125a-5p on apoptosis; In loss-of-function experiments wild-type p53 mRNA and protein expression was decreased by blocking hsa-miR-125a-5p; The effect of hsa-miR-125a-5p inhibitor on apoptosis was also weakened by blocking wild-type p53;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity tumorigenesis;; cervical and endocervical cancer;lung cancer;liver cancer hsa-miR-125b-5p TP53 -0.176364454911029 0.43771853581292 0.511940387522054 0.00485905823274999 miRNAWalker2_validate;miRTarBase -0.117991649104916 0.0168993998720041 24846940;26335100;24137477;26686386;24402874;21399871;23585871;24762088;24169356;23079745 The results revealed that hsa-miR-125b may regulate multiple biological processes and signal transduction pathways and drug-resistant occurrence is associated with cell proliferation cell apoptosis cell cycle and signaling pathways including MAPK Wnt and p53;The carboxy terminal domain of connexin 43 CT Cx43 modulates the expression of p53 by altering miR 125b expression in low grade human breast cancers; In addition CT-Cx43 was exogenously expressed in the breast cancer-derived cell line MCF-7 and its effect on the expression of miR-125b and its downstream target p53 were evaluated as well as its effect on cellular proliferation and death using MTT and LDH assays respectively; Interestingly we found that miR-125b a negative regulator of p53 exhibited an inverse expression relationship with CT-Cx43 in the breast cancer samples tested;TP53 and hsa-miR-125b were observed to form a self-adaptation association;In this study we have investigated the delivery and transfection of wild-type wt- p53 and microRNA-125b miR-125b expressing plasmid DNA in SK-LU-1 human lung adenocarcinoma cells as well as in KrasG12D/p53fl/fl KP genetically engineered mouse model of lung cancer;miR-34a is directly regulated by p53 and acts as tumor suppressor while miR-125b plays a significant role in immune response and apoptosis;In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of p53 protein in human colorectal cancer cells;In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b;A stable overexpression of miR-125b in human melanoma cell line Mel-Juso resulted in a G0/G1 cell cycle block and emergence of large cells expressing senescence markers: senescence-associated beta-galactosidase p21 p27 and p53;MiR 125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK independent pathways; Further studies reveal that p53 is regulated by miR-125b; However downregulation of the endogenous miR-125b also results in p53-independent apoptotic pathway leading to apoptosis in p53 mutated U251 cells and p53 knockdown U87 cells;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity; To show the clinical significance of these findings mutations in the DNA binding domain of p53 and promoter methylation of miR-125b were investigated; Four out of nine patients with induced SIRT7 carried mutations in the p53 gene and one patient showed hypermethylation of the miR-125b promoter region ;;;;immune resistance;;;;; gastric cancer;breast cancer;pancreatic cancer;lung cancer;cervical and endocervical cancer;colorectal cancer;prostate cancer;melanoma;glioblastoma;liver cancer hsa-miR-16-5p TPBG 0.468459442059375 0.02635007201346 0.369493271529142 0.0785185687561158 miRNAWalker2_validate -0.137656399170544 0.0242836164782855 NA NA NA hsa-miR-16-5p TPM2 0.468459442059375 0.02635007201346 -1.44754409328087 2.79634378563248e-05 MirTarget -0.94863015471608 2.40210147239775e-24 NA NA NA hsa-miR-16-5p TRAF6 0.468459442059375 0.02635007201346 -0.0475358370197787 0.563801051918788 MirTarget -0.133053504945983 7.99894072188029e-09 NA NA NA hsa-miR-16-5p TRIM2 0.468459442059375 0.02635007201346 -0.138593633483852 0.426294696378046 miRNATAP -0.114884466781375 0.0229941273299049 NA NA NA hsa-miR-16-5p TRIM44 0.468459442059375 0.02635007201346 0.233049598119167 0.0170626883391029 miRNAWalker2_validate -0.101563909825474 0.000303841267426099 NA NA NA hsa-miR-16-5p TRIM67 0.468459442059375 0.02635007201346 0.880922933596874 0.000527737940631189 mirMAP -0.21591707897544 0.00369467901470395 NA NA NA hsa-miR-16-5p TRPC1 0.468459442059375 0.02635007201346 -0.704677053980514 0.00534368864806038 MirTarget -0.746361470702179 1.64799367624157e-29 NA NA NA hsa-miR-16-5p TSC22D3 0.468459442059375 0.02635007201346 -1.74603210320545 3.61843236827956e-15 miRNATAP -0.26858579117762 6.95185874755113e-05 NA NA NA hsa-miR-16-5p TSPAN5 0.468459442059375 0.02635007201346 -1.05916819146055 6.72366925707668e-07 MirTarget;miRNATAP -0.135306255205158 0.0326235920061623 NA NA NA hsa-miR-16-5p TSPYL2 0.468459442059375 0.02635007201346 -0.863367135773039 5.20650702866693e-06 MirTarget;miRNATAP -0.391407685702923 2.72823092334046e-13 26640145 First we examined the expression of miR-16 in primary cutaneous T-cell lymphoma CTCL and other non-Hodgkin T/natural killer NK-cell lymphomas and found that miR-16 was downregulated than that in the corresponding normal cells; Notably miR-16 expression was reduced as the primary CTCL progressed from the early stage to the advanced stage; Next we transduced CTCL cells with miR-16 to examine whether this miRNA exhibited tumor-suppressive effects in CTCL cells; Alternatively in CTCL cells lacking functional p53 miR-16 induced compensatory apoptosis; Elucidation of the essential targets of miR-16 and SAHA provides a basis for the clinical application of SAHA in the treatment of CTCL and other non-Hodgkin T/NK-cell lymphomas staging;progression lymphoma hsa-miR-16-5p TTC14 0.468459442059375 0.02635007201346 -0.165834824080406 0.370234160666997 miRNATAP -0.293604723601557 2.09918610074207e-08 NA NA NA hsa-miR-16-5p TTC21B 0.468459442059375 0.02635007201346 0.218949158239465 0.0422280171667745 miRNATAP -0.156970644149879 2.99135102165412e-07 NA NA NA hsa-miR-16-5p TTC25 0.468459442059375 0.02635007201346 -0.207867283825482 0.382608322490927 MirTarget -0.282249799431263 3.65369928658277e-05 NA NA NA hsa-miR-129-5p TTK -1.61803714443871 4.93214379865694e-06 2.26875872529928 1.00436025645218e-18 miRanda -0.178612048319459 0.000152892168312712 NA NA NA hsa-miR-139-5p TTK -1.41674256628297 4.51005988644234e-14 2.26875872529928 1.00436025645218e-18 miRanda -0.681333626306651 3.52960663294193e-17 NA NA NA hsa-miR-16-5p UBE4B 0.468459442059375 0.02635007201346 -0.234890160403762 0.00699649400950057 MirTarget;miRNATAP -0.185943088507879 8.92131567625205e-15 NA NA NA hsa-miR-16-5p UBL3 0.468459442059375 0.02635007201346 -0.925691828169475 5.01551726319136e-15 MirTarget -0.136976506498242 0.000135164682036558 NA NA NA hsa-miR-16-5p UBR3 0.468459442059375 0.02635007201346 -0.0206777423176625 0.827742242328184 MirTarget;miRNATAP -0.187146405182924 1.00357604876108e-12 NA NA NA hsa-miR-16-5p UBXN10 0.468459442059375 0.02635007201346 -0.722631468061429 0.0447174779262154 MirTarget;miRNATAP -0.610379742544682 2.14688719679611e-09 NA NA NA hsa-miR-16-5p UBXN2B 0.468459442059375 0.02635007201346 0.327813841384824 0.00202369927290284 miRNAWalker2_validate -0.113265106458724 0.00022432639649982 NA NA NA hsa-miR-16-5p UFSP2 0.468459442059375 0.02635007201346 -0.78816433786614 5.31514088671543e-14 miRNAWalker2_validate -0.18814597276805 1.21325377834876e-09 NA NA NA hsa-miR-16-5p ULK1 0.468459442059375 0.02635007201346 -0.179934913251413 0.111381698496373 miRNAWalker2_validate -0.189178192657291 2.75973666206298e-09 NA NA NA hsa-miR-16-5p UNC80 0.468459442059375 0.02635007201346 -1.93440601889881 3.16732101418133e-06 MirTarget;miRNATAP -0.746093000250636 3.85814657851128e-10 NA NA NA hsa-miR-16-5p USP12 0.468459442059375 0.02635007201346 -0.101794564798544 0.407677769454764 MirTarget;miRNATAP -0.239551604400941 2.26772100898242e-12 NA NA NA hsa-miR-16-5p USP2 0.468459442059375 0.02635007201346 -2.19721865185727 1.17166813672625e-12 miRNATAP -0.644407693417875 8.58072640442066e-13 NA NA NA hsa-miR-16-5p USP31 0.468459442059375 0.02635007201346 0.970416721014479 1.34505246312873e-16 MirTarget -0.150295557042634 2.59547027369819e-05 NA NA NA hsa-miR-16-5p USP44 0.468459442059375 0.02635007201346 -0.655521376200348 0.0247774577651161 MirTarget -0.765735253728553 1.5167082184552e-22 NA NA NA hsa-miR-16-5p USP53 0.468459442059375 0.02635007201346 -0.383332121028338 0.00131809074213516 miRNAWalker2_validate;miRNATAP -0.18730987369828 3.70046821714942e-08 NA NA NA hsa-miR-16-5p USP6 0.468459442059375 0.02635007201346 0.187960680685821 0.387097160375696 miRNATAP -0.165324341445257 0.00867809284802911 NA NA NA hsa-miR-16-5p VASN 0.468459442059375 0.02635007201346 0.0664869223566349 0.704313801335507 miRNAWalker2_validate -0.206696467666438 3.8746070379679e-05 NA NA NA hsa-miR-16-5p VAT1 0.468459442059375 0.02635007201346 -0.13395822096223 0.355205390940839 MirTarget;miRNATAP -0.120092706867843 0.00412761026296889 NA NA NA hsa-miR-16-5p VCL 0.468459442059375 0.02635007201346 -0.110736733751609 0.514952145261565 miRNAWalker2_validate -0.498871721586695 1.08134237321109e-29 NA NA NA hsa-miR-16-5p VIM 0.468459442059375 0.02635007201346 -0.315902381310506 0.0583233355839757 miRNAWalker2_validate -0.163866687935272 0.000679944450139554 NA NA NA hsa-miR-16-5p VPS13B 0.468459442059375 0.02635007201346 0.355265011270777 0.00171278261576175 mirMAP -0.15989936862267 8.33295316725262e-07 NA NA NA hsa-miR-16-5p VPS45 0.468459442059375 0.02635007201346 -0.27328327087376 0.000562153109247503 miRNAWalker2_validate -0.109543110124209 1.2895994272735e-06 NA NA NA hsa-miR-16-5p VWF 0.468459442059375 0.02635007201346 0.19886176095982 0.31079150620286 mirMAP -0.151394699339793 0.00774928172095829 NA NA NA hsa-miR-16-5p WBP1L 0.468459442059375 0.02635007201346 -0.377971404363762 8.29956294454323e-05 mirMAP -0.139143565023882 4.48220513869153e-07 NA NA NA hsa-miR-16-5p WDR47 0.468459442059375 0.02635007201346 -0.378252468795409 0.000312581763040392 MirTarget;miRNATAP -0.231647453217504 1.51454150104829e-15 NA NA NA hsa-let-7a-3p WEE1 0.283468597868531 0.127007787220086 -0.0579007535730272 0.673440236749829 mirMAP;miRNATAP -0.103290468447008 0.0229357672091355 NA NA NA hsa-let-7b-3p WEE1 0.377956364821509 0.0061730103051373 -0.0579007535730272 0.673440236749829 mirMAP;miRNATAP -0.206328933248329 0.000736758893226824 NA NA NA hsa-miR-140-5p WEE1 0.132398579631585 0.457960134430787 -0.0579007535730272 0.673440236749829 PITA;miRanda -0.18577484051852 7.60943673383819e-05 NA NA NA hsa-miR-195-5p WEE1 -1.07154705036962 4.16544134775761e-08 -0.0579007535730272 0.673440236749829 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.178028991259314 1.77025396139394e-05 22847610 Regulation of cell cycle checkpoint kinase WEE1 by miR 195 in malignant melanoma; Moreover there was an inverse correlation between the expression of WEE1 and WEE1-targeting microRNA miR-195; Further analyses showed that transfection of melanoma cell lines with miR-195 indeed reduced WEE1 mRNA and protein expression in these cells; Reporter gene analysis confirmed direct targeting of the WEE1 3' untranslated region 3'UTR by miR-195; Overexpression of miR-195 in SK-Mel-28 melanoma cells was accompanied by WEE1 reduction and significantly reduced stress-induced G2-M cell cycle arrest which could be restored by stable overexpression of WEE1; Moreover miR-195 overexpression and WEE1 knockdown respectively increased melanoma cell proliferation; Taken together the present study shows that WEE1 expression in malignant melanoma is directly regulated by miR-195 miR-195-mediated downregulation of WEE1 in metastatic lesions may help to overcome cell cycle arrest under stress conditions in the local tissue microenvironment to allow unrestricted growth of tumour cells malignant trasformation melanoma hsa-miR-424-5p WEE1 0.956135912596328 0.00035164943928494 -0.0579007535730272 0.673440236749829 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.106750210444417 0.000530588537520603 NA NA NA hsa-miR-497-5p WEE1 -0.486115215577409 0.00973897247186318 -0.0579007535730272 0.673440236749829 MirTarget;miRNATAP -0.194963860384954 9.61629545096995e-06 NA NA NA hsa-miR-16-5p WISP1 0.468459442059375 0.02635007201346 2.17483053056854 1.6208081868066e-16 MirTarget -0.250507790939233 0.00203183985626867 NA NA NA hsa-miR-16-5p WNK3 0.468459442059375 0.02635007201346 -0.566384750663729 0.0267756841098298 miRNATAP -0.716867937756067 2.73841059250448e-26 NA NA NA hsa-miR-16-5p WNT9A 0.468459442059375 0.02635007201346 -1.39860250502631 0.000264930163673997 mirMAP -1.03043095990865 2.16591074259425e-23 NA NA NA hsa-miR-16-5p WTIP 0.468459442059375 0.02635007201346 -0.203064079884611 0.334942845307838 mirMAP -0.313767050328655 1.60473825500706e-07 NA NA NA hsa-miR-16-5p XYLT1 0.468459442059375 0.02635007201346 -0.197036506362473 0.248263224443978 miRNAWalker2_validate;mirMAP -0.252517924114033 1.94037494112402e-07 NA NA NA hsa-miR-152-3p YWHAB -0.111001946024117 0.385698870309139 0.358450947948359 0.000102547253240136 MirTarget -0.179350543423211 6.71755050267786e-05 NA NA NA hsa-miR-28-3p YWHAB -0.247525872199168 0.0399632425440147 0.358450947948359 0.000102547253240136 mirMAP -0.182926147443985 0.000132030842494469 NA NA NA hsa-let-7e-5p YWHAE 0.227253058773149 0.162290058199053 0.0014146052214663 0.989053236383299 miRNAWalker2_validate -0.145244264457431 0.000171335631614497 NA NA NA hsa-miR-100-5p YWHAE -0.343735526262058 0.133995182819209 0.0014146052214663 0.989053236383299 miRNAWalker2_validate -0.165321463960734 4.66054831564133e-10 NA NA NA hsa-miR-199a-5p YWHAE 0.723739336873244 5.69674696426761e-05 0.0014146052214663 0.989053236383299 miRanda -0.126354603451383 0.00023919407949176 NA NA NA hsa-miR-30a-3p YWHAE -1.27950866170419 4.33230022379782e-09 0.0014146052214663 0.989053236383299 miRNAWalker2_validate;MirTarget;miRNATAP -0.110793730596684 6.37860699089308e-05 NA NA NA hsa-miR-30a-5p YWHAE -0.742755040631906 3.79943871404435e-05 0.0014146052214663 0.989053236383299 miRNAWalker2_validate -0.185372712608919 3.9245917940403e-08 NA NA NA hsa-miR-139-5p YWHAG -1.41674256628297 4.51005988644234e-14 0.478543013351851 2.65743654788031e-07 MirTarget;PITA;miRanda;miRNATAP -0.158866302782212 3.42487732094063e-08 NA NA NA hsa-miR-140-3p YWHAG -0.0247056136502994 0.830704277191343 0.478543013351851 2.65743654788031e-07 MirTarget;PITA;miRNATAP -0.222790199893634 1.24269618544803e-05 NA NA NA hsa-miR-30a-5p YWHAG -0.742755040631906 3.79943871404435e-05 0.478543013351851 2.65743654788031e-07 miRNATAP -0.129299012166129 4.16783465450433e-05 NA NA NA hsa-miR-30e-5p YWHAG -0.284839730810255 0.0405852891523165 0.478543013351851 2.65743654788031e-07 miRNATAP -0.109692567604298 0.00934652685443653 NA NA NA hsa-miR-361-3p YWHAG 0.485361250955594 0.00074097948047418 0.478543013351851 2.65743654788031e-07 miRNATAP -0.118409146649712 0.0033726001793077 NA NA NA hsa-miR-195-5p YWHAQ -1.07154705036962 4.16544134775761e-08 -0.00973354065713039 0.900690881591244 MirTarget;miRNATAP -0.111205053185529 1.74086595049359e-06 NA NA NA hsa-miR-497-5p YWHAQ -0.486115215577409 0.00973897247186318 -0.00973354065713039 0.900690881591244 MirTarget;miRNATAP -0.144445884894949 3.47651310790627e-09 NA NA NA hsa-miR-125a-5p YWHAZ -0.261743402170195 0.116107665196876 0.282448372408636 0.00823530141414023 miRanda -0.120899994936991 0.00222341225944007 NA NA NA hsa-miR-195-3p YWHAZ -0.694544351365025 0.000214711021317786 0.282448372408636 0.00823530141414023 MirTarget -0.22109891500738 4.56089153567995e-11 NA NA NA hsa-miR-199a-5p YWHAZ 0.723739336873244 5.69674696426761e-05 0.282448372408636 0.00823530141414023 miRanda -0.125296507021549 0.000493781046348479 NA NA NA hsa-miR-28-5p YWHAZ -0.22318016376076 0.0194144033008573 0.282448372408636 0.00823530141414023 PITA;miRanda;miRNATAP -0.256096950848326 0.000309149258141861 NA NA NA hsa-miR-30a-5p YWHAZ -0.742755040631906 3.79943871404435e-05 0.282448372408636 0.00823530141414023 miRNAWalker2_validate;MirTarget;miRNATAP -0.220719706054169 2.57782171927733e-10 NA NA NA hsa-miR-16-5p ZBTB10 0.468459442059375 0.02635007201346 0.11491226178643 0.650172271983559 MirTarget;miRNATAP -0.381519694241523 1.15731998710913e-07 NA NA NA hsa-miR-16-5p ZBTB44 0.468459442059375 0.02635007201346 0.264727540057518 0.0098977316167743 MirTarget;miRNATAP -0.124151854810438 2.49726964596567e-05 NA NA NA hsa-miR-16-5p ZC2HC1A 0.468459442059375 0.02635007201346 -0.368582106321495 0.049622481836739 MirTarget -0.41596714358493 8.47011671388647e-16 NA NA NA hsa-miR-16-5p ZC3H11A 0.468459442059375 0.02635007201346 0.413459822094182 2.09330575787052e-06 miRNAWalker2_validate -0.10531188165919 3.23302777325017e-05 NA NA NA hsa-miR-16-5p ZC3H12B 0.468459442059375 0.02635007201346 -0.250832462540052 0.257150410374074 miRNATAP -0.489151280924922 8.96765582437468e-16 NA NA NA hsa-miR-16-5p ZC3H12C 0.468459442059375 0.02635007201346 -0.811123594545078 0.000172087654901931 MirTarget -0.292374961726643 2.88023555590377e-06 NA NA NA hsa-miR-16-5p ZC3H13 0.468459442059375 0.02635007201346 0.294905422502363 0.0153515337103235 MirTarget -0.203463220937597 3.32263508939899e-09 NA NA NA hsa-miR-16-5p ZC3H6 0.468459442059375 0.02635007201346 -0.421092141864099 0.00728833157985793 miRNATAP -0.427099897277439 1.57495966260979e-24 NA NA NA hsa-miR-16-5p ZCCHC5 0.468459442059375 0.02635007201346 -0.953061160218104 0.0518339911676993 MirTarget;miRNATAP -1.18224350365735 8.30232387728479e-19 NA NA NA hsa-miR-16-5p ZDHHC15 0.468459442059375 0.02635007201346 -1.35902684957062 3.39400626126344e-06 MirTarget -0.835972197372081 1.71671016110874e-26 NA NA NA hsa-miR-16-5p ZDHHC21 0.468459442059375 0.02635007201346 -0.389259000015898 0.0125589928320564 MirTarget -0.166305179551208 0.000225551941224307 NA NA NA hsa-miR-16-5p ZER1 0.468459442059375 0.02635007201346 -0.843542777878835 2.68084128932977e-18 miRNATAP -0.136662374476317 3.55310173977086e-06 NA NA NA hsa-miR-16-5p ZFHX3 0.468459442059375 0.02635007201346 0.388625553932512 0.0136343956376204 miRNAWalker2_validate;MirTarget;miRNATAP -0.377058644457464 1.63897183645529e-18 NA NA NA hsa-miR-16-5p ZFHX4 0.468459442059375 0.02635007201346 0.0184972294773713 0.955736809911936 MirTarget;miRNATAP -0.840301905618063 7.04076893721668e-21 NA NA NA hsa-miR-16-5p ZFYVE1 0.468459442059375 0.02635007201346 -0.662930192090126 1.00517576029795e-12 MirTarget -0.136815651732616 7.16008815855908e-07 NA NA NA hsa-miR-16-5p ZHX1 0.468459442059375 0.02635007201346 -0.327274762239904 0.00108963461153885 miRNATAP -0.131284165039592 5.05088036926635e-06 NA NA NA hsa-miR-16-5p ZHX3 0.468459442059375 0.02635007201346 -0.48569389286767 0.00067184703404714 mirMAP -0.368219477458294 1.52963857706995e-21 NA NA NA hsa-miR-16-5p ZMAT3 0.468459442059375 0.02635007201346 0.27771952020038 0.0499447683089053 MirTarget -0.250718319575479 3.16552165472125e-10 NA NA NA hsa-miR-16-5p ZMIZ1 0.468459442059375 0.02635007201346 -0.270187558061514 0.0214648981477033 mirMAP -0.199953102737691 1.61306161956236e-09 NA NA NA hsa-miR-16-5p ZMYM2 0.468459442059375 0.02635007201346 0.278969072922853 0.0127298205019214 MirTarget;miRNATAP -0.107216484818975 0.00092400105727866 NA NA NA hsa-miR-16-5p ZNF304 0.468459442059375 0.02635007201346 -0.152735534634012 0.388371916645428 miRNATAP -0.202808882685971 6.65324657232416e-05 NA NA NA hsa-miR-16-5p ZNF346 0.468459442059375 0.02635007201346 -0.180741914324089 0.0261218104301725 MirTarget -0.109114332072606 2.2877423156162e-06 NA NA NA hsa-miR-16-5p ZNF362 0.468459442059375 0.02635007201346 -0.231025493088191 0.0584071488986172 MirTarget;miRNATAP -0.219619044496197 1.42139877511339e-10 NA NA NA hsa-miR-16-5p ZNF423 0.468459442059375 0.02635007201346 -0.207391944090895 0.423116370581353 miRNATAP -0.735653062862581 2.13502992575839e-27 NA NA NA hsa-miR-16-5p ZNF436 0.468459442059375 0.02635007201346 0.0426050131527091 0.706505156892831 miRNATAP -0.23806880506761 1.95870134033813e-14 NA NA NA hsa-miR-16-5p ZNF445 0.468459442059375 0.02635007201346 0.353019491783618 0.00152699832029871 mirMAP -0.189077528040963 2.08714222513004e-09 NA NA NA hsa-miR-16-5p ZNF449 0.468459442059375 0.02635007201346 0.27714056761396 0.0126076680026678 MirTarget;miRNATAP -0.216930582245544 2.53982119554305e-12 NA NA NA hsa-miR-16-5p ZNF512B 0.468459442059375 0.02635007201346 -0.566120168951347 0.0123439167408622 mirMAP -0.212932590216009 0.00119258743821462 NA NA NA hsa-miR-16-5p ZNF516 0.468459442059375 0.02635007201346 -0.530173332560438 0.00170477542591741 mirMAP -0.31458905969333 4.2138822807807e-11 NA NA NA hsa-miR-16-5p ZNF518B 0.468459442059375 0.02635007201346 -0.810348186681662 0.0007591643900906 MirTarget -0.344330536945479 6.74884917462926e-07 NA NA NA hsa-miR-16-5p ZNF532 0.468459442059375 0.02635007201346 0.410685792071696 0.016269152211887 miRNATAP -0.366707843570935 9.31727363552204e-15 NA NA NA hsa-miR-16-5p ZNF559 0.468459442059375 0.02635007201346 -0.387591208206637 0.0421037750846807 miRNAWalker2_validate -0.238358334434327 1.36453928905374e-05 NA NA NA hsa-miR-16-5p ZNF621 0.468459442059375 0.02635007201346 0.327989171873721 0.000586117712565943 mirMAP -0.161927537552933 2.0684525744718e-09 NA NA NA hsa-miR-16-5p ZNF638 0.468459442059375 0.02635007201346 0.219653727561941 0.0121365547102358 miRNAWalker2_validate -0.139668545944673 1.62822024571037e-08 NA NA NA hsa-miR-16-5p ZNF644 0.468459442059375 0.02635007201346 0.311066122067824 0.000229055656772785 miRNAWalker2_validate -0.107956234915893 8.61839277679403e-06 NA NA NA hsa-miR-16-5p ZNF654 0.468459442059375 0.02635007201346 -0.136763612417804 0.16769732511067 MirTarget;miRNATAP -0.151004949583604 6.9869261045331e-08 NA NA NA hsa-miR-16-5p ZNF662 0.468459442059375 0.02635007201346 -1.88043061006014 2.81229008426511e-10 MirTarget -0.713543490872537 2.94726352828946e-17 NA NA NA hsa-miR-16-5p ZNF704 0.468459442059375 0.02635007201346 -0.446994599853389 0.116513806383905 MirTarget -0.455679229844569 1.717454615409e-08 NA NA NA hsa-miR-16-5p ZNF791 0.468459442059375 0.02635007201346 -0.106503770536559 0.279161855371516 miRNAWalker2_validate -0.220534873959054 1.9402934728099e-16 NA NA NA hsa-miR-16-5p ZNF827 0.468459442059375 0.02635007201346 -0.237884564535214 0.159114228091213 miRNAWalker2_validate -0.243762825335322 4.06827072685531e-07 NA NA NA hsa-miR-16-5p ZRANB1 0.468459442059375 0.02635007201346 -0.162987253940597 0.104519813914062 miRNAWalker2_validate -0.197768808324089 1.20008165314785e-12 NA NA NA hsa-miR-16-5p ZYX 0.468459442059375 0.02635007201346 0.0190993450459676 0.897633139069276 miRNAWalker2_validate;miRTarBase;miRNATAP -0.203714199850782 1.44088880610258e-06 NA NA NA