miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-125b-5p AIFM1 -1.16462950151259 0.000288900271798384 0.303056224316474 0.00499225344172376 miRNATAP -0.087393754623017 3.8935672467902e-08 NA NA NA hsa-miR-145-5p AIFM1 -1.55259331973517 9.97889123247165e-07 0.303056224316474 0.00499225344172376 miRNATAP -0.0514336170590221 0.00148792684291437 20332243 Artificial overexpression of miR145 by using adenoviral vectors in prostate cancer PC-3 and DU145 cells significantly downregulated BNIP3 together with the upregulation of AIF reduced cell growth and increased cell death prostate cancer hsa-miR-199a-5p AIFM1 0.592984035153911 0.0674836634175293 0.303056224316474 0.00499225344172376 miRanda -0.0621640883463547 0.00010057893785087 NA NA NA hsa-miR-125b-5p AKT1 -1.16462950151259 0.000288900271798384 0.128947014292221 0.203881780391473 miRNAWalker2_validate;miRTarBase -0.0754219304397887 4.30762607612109e-07 NA NA NA hsa-miR-365a-3p AKT1 -0.0388985816963467 0.859114494267351 0.128947014292221 0.203881780391473 mirMAP -0.0728473542292503 0.00113891312915844 24149576 Importantly genetic ablation of Akt1 restores miR-365 expression and effectively rescues gastric tumorigenesis in PTEN-mutant mice tumorigenesis gastric cancer hsa-miR-22-3p AKT2 1.21545661147757 1.61670170137775e-13 -0.0302247278777559 0.77731841275645 mirMAP -0.0946689309918694 0.00202026831084691 NA NA NA hsa-miR-338-3p AKT2 0.453166438193782 0.144583389707558 -0.0302247278777559 0.77731841275645 mirMAP -0.0558618567359771 0.000709778409691823 NA NA NA hsa-miR-365a-3p AKT2 -0.0388985816963467 0.859114494267351 -0.0302247278777559 0.77731841275645 mirMAP -0.0706931963599922 0.00273734855865171 NA NA NA hsa-miR-101-3p AKT3 0.522819989585461 0.00375627731618038 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.334857831597034 0.000597756240419548 NA NA NA hsa-miR-106a-5p AKT3 2.48882002962836 1.99757727374521e-12 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.236478824223264 6.56988295029948e-07 NA NA NA hsa-miR-106b-5p AKT3 2.46782146831112 1.36171495805632e-23 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.521755012930227 1.0756262414999e-15 NA NA NA hsa-miR-107 AKT3 1.30977326593435 1.30372468603965e-11 -1.94162990884529 4.54380296394505e-08 PITA;miRanda -0.438321009170574 6.41595199298462e-07 NA NA NA hsa-miR-15a-5p AKT3 2.34669284378787 1.69544424500258e-23 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.653282073492048 2.38693369892811e-22 NA NA NA hsa-miR-15b-5p AKT3 1.57112623124278 9.14247846750597e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.4862313443712 1.80429141906685e-10 NA NA NA hsa-miR-16-5p AKT3 1.75824877145857 1.68592440033108e-16 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.527819854451446 1.06852141480407e-11 NA NA NA hsa-miR-17-3p AKT3 2.2704817679209 1.1667437320211e-22 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.393678889428456 2.72155279297878e-08 NA NA NA hsa-miR-17-5p AKT3 3.2710598467455 9.93128340539455e-27 -1.94162990884529 4.54380296394505e-08 TargetScan;miRNATAP -0.385876321416217 1.42856705542315e-13 NA NA NA hsa-miR-181a-5p AKT3 2.29556023480783 1.8138457900616e-21 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.283343247743329 3.77571043690309e-05 NA NA NA hsa-miR-181b-5p AKT3 2.49307679431293 3.92829250217627e-20 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.273550202394616 7.65012329836386e-06 NA NA NA hsa-miR-181c-5p AKT3 1.58587920618301 1.57506918816933e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.234902996176996 0.000670085449584041 NA NA NA hsa-miR-20a-5p AKT3 3.15577933619191 4.19753346442454e-25 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.397380097014522 3.56434655429537e-14 NA NA NA hsa-miR-20b-5p AKT3 2.07706563022469 1.10107236083433e-05 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.159136097484426 1.15057100055016e-05 NA NA NA hsa-miR-22-3p AKT3 1.21545661147757 1.61670170137775e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.356198759053997 0.000637369773108939 NA NA NA hsa-miR-29b-2-5p AKT3 0.910668640983475 0.00666655585493488 -1.94162990884529 4.54380296394505e-08 mirMAP -0.413342005890553 1.74596670459023e-16 NA NA NA hsa-miR-29b-3p AKT3 1.65828197923813 1.02676780888141e-09 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.328715384299769 1.41956551647306e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-29c-3p AKT3 -0.00968972577705429 0.97099586346872 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRNATAP -0.256484648428124 9.16722320814547e-05 NA NA NA hsa-miR-3065-5p AKT3 2.74629919868982 1.86846589298284e-08 -1.94162990884529 4.54380296394505e-08 mirMAP -0.196776388311872 4.09483787014971e-06 NA NA NA hsa-miR-32-3p AKT3 2.02436999565685 5.94091197945307e-09 -1.94162990884529 4.54380296394505e-08 mirMAP -0.274043726011417 8.75730973684685e-07 NA NA NA hsa-miR-320a AKT3 0.438165828017084 0.0390159073347133 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.539139659729602 3.01448987258332e-11 NA NA NA hsa-miR-320b AKT3 1.55692969039548 1.41071034251915e-08 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.376164976249955 1.04134326075959e-09 NA NA NA hsa-miR-335-3p AKT3 3.08791651139852 5.31309869723517e-12 -1.94162990884529 4.54380296394505e-08 mirMAP -0.222130607012057 2.63416728864213e-09 NA NA NA hsa-miR-33a-3p AKT3 1.72765312072219 1.51784443453521e-07 -1.94162990884529 4.54380296394505e-08 mirMAP -0.325733544419159 9.28241682908522e-09 NA NA NA hsa-miR-362-3p AKT3 2.0756816987665 3.89026064579331e-12 -1.94162990884529 4.54380296394505e-08 miRanda -0.16536843343699 0.0049777492806053 NA NA NA hsa-miR-362-5p AKT3 1.59303749908759 9.582675908797e-08 -1.94162990884529 4.54380296394505e-08 PITA;TargetScan;miRNATAP -0.201169258976553 0.000472996311050305 NA NA NA hsa-miR-374a-5p AKT3 0.484615721953736 0.0042981729815149 -1.94162990884529 4.54380296394505e-08 mirMAP -0.289501808595266 0.00547104114009117 NA NA NA hsa-miR-421 AKT3 1.17791565395543 6.78526676976629e-06 -1.94162990884529 4.54380296394505e-08 miRanda;mirMAP -0.270003673244585 4.40560995362011e-05 NA NA NA hsa-miR-501-3p AKT3 1.83132758513743 1.10971547702065e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.357094776714992 1.69773165528929e-09 NA NA NA hsa-miR-502-3p AKT3 1.50560877085049 1.2647489756373e-11 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.326505295822604 2.04961437337709e-05 NA NA NA hsa-miR-505-3p AKT3 1.45322244209148 8.86597629645867e-10 -1.94162990884529 4.54380296394505e-08 mirMAP -0.409352554521824 1.03207996907079e-08 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-769-5p AKT3 1.82023760596845 9.6815886564134e-14 -1.94162990884529 4.54380296394505e-08 PITA;miRNATAP -0.445071301297515 6.71512496875401e-11 NA NA NA hsa-miR-93-5p AKT3 3.03961860136032 1.11672209617395e-24 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.494281511913237 1.38435165024812e-20 NA NA NA hsa-miR-139-5p APAF1 -1.52606598644743 1.20474151350665e-08 0.392057672964835 0.00374480729317335 mirMAP -0.0516641324392396 0.0322646900265725 NA NA NA hsa-miR-181a-5p ATM 2.29556023480783 1.8138457900616e-21 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.126923788457429 2.84207726303723e-05 24531888;27150990;21102523;26113450;23656790 Ataxia-telangiectasia mutation ATM was predicted as a target gene of miR-181a with bioinformatics analysis and was verified by lucifersae reporter assay; A luciferase reporter assay demonstrated that ATM was a direct target of miR-181a miR-181a mimics transfection down regulated ATM mRNA and protein expression; There was inverse correlation between miR-181a and ATM protein expression in gastric cancer and normal gastric tissues; Our study demonstrates that over-expression of miR-181a might be involved in development of gastric cancer by promoting proliferation and inhibiting apoptosis probably through directly targeting ATM miR-181a modulation may be a potential strategy for the development of miRNA-based therapy of gastric cancer;MiR 181a Promotes Proliferation of Human Acute Myeloid Leukemia Cells by Targeting ATM; Dual luciferase reporter gene assay showed that miR-181a significantly suppressed the reporter gene activity containing ATM 3'-UTR by about 56.8% P < 0.05 but it didn't suppress the reporter gene activity containing 3'-UTR ATM mutation; Western blot showed that miR-181a significantly downregulated the expression of ATM in human leukemia cells; It is also found that miR-181a was significantly increased in AML which showed a negative correlation with ATM expression; miR-181a promotes cell proliferation in AML by regulating the tumor suppressor ATM thus it plays the role as oncogene in pathogenesis of AML;Ataxia telangiectasia mutated ATM a target gene of miR-181 exhibited reduced expression in mammospheres and upon TGF-β treatment;miR 181a promotes G1/S transition and cell proliferation in pediatric acute myeloid leukemia by targeting ATM; Pediatric AML patients and healthy controls were enrolled and the expression of miR-181a and ataxia telangiectasia mutated ATM in tissues were examined using quantitative PCR; Moreover cell proliferation and cell cycle were evaluated in several cell lines HL60 NB4 and K562 by using flow cytometry after transfected with miR-181a mimics and inhibitors or ATM siRNA and control siRNA; Finally ATM as the potential target protein of miR-181a was examined; We found that miR-181a was significantly increased in pediatric AML which showed an inverse association with ATM expression; Luciferase activity of the reporter construct identified ATM as the direct molecular target of miR-181a; The results revealed novel mechanism through which miR-181a regulates G1/S transition and cell proliferation in pediatric AML by regulating the tumor suppressor ATM providing insights into the molecular mechanism in pediatric AML;We report that miR-181a and miR-181b were overexpressed in more aggressive breast cancers and their expression correlates inversely with ATM levels ;;;; gastric cancer;acute myeloid leukemia;breast cancer;acute myeloid leukemia;breast cancer hsa-miR-181b-5p ATM 2.49307679431293 3.92829250217627e-20 -0.694304374354523 1.11905560067279e-05 MirTarget -0.106546210489637 8.13310251996423e-05 21102523;23656790 Ataxia telangiectasia mutated ATM a target gene of miR-181 exhibited reduced expression in mammospheres and upon TGF-β treatment;We report that miR-181a and miR-181b were overexpressed in more aggressive breast cancers and their expression correlates inversely with ATM levels ; breast cancer;breast cancer hsa-miR-181c-5p ATM 1.58587920618301 1.57506918816933e-10 -0.694304374354523 1.11905560067279e-05 MirTarget -0.0964110139012526 0.00156794160688583 NA NA NA hsa-miR-181d-5p ATM 1.52204912185579 9.2693319057748e-08 -0.694304374354523 1.11905560067279e-05 MirTarget -0.0998255068171203 0.000176847482330073 NA NA NA hsa-miR-186-5p ATM 1.47445398888668 3.0781726595413e-15 -0.694304374354523 1.11905560067279e-05 mirMAP -0.162572896698222 4.94897138455636e-05 NA NA NA hsa-miR-18a-5p ATM 3.78535678765353 3.72446596213886e-26 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.132647027735553 2.53006799595493e-10 23437304;25963391;23857602;23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression colorectal cancer;cervical and endocervical cancer;breast cancer;colon cancer hsa-miR-19b-3p ATM 2.49529833021187 1.57028265846699e-23 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate -0.169669050219426 4.03808006538527e-09 NA NA NA hsa-miR-21-5p ATM 2.73773305747971 1.38864982139576e-43 -0.694304374354523 1.11905560067279e-05 mirMAP -0.176310423151013 4.47713388674926e-07 26289851 MiR-21 is an oncomiR that is overexpressed in nearly all cancers including ATC; Hence suppression of miR-21 could pave the way for ATC therapy thyroid cancer hsa-miR-26a-2-3p ATM 0.823520019989974 0.00017092160823769 -0.694304374354523 1.11905560067279e-05 MirTarget -0.118965349103283 0.000759103078575479 NA NA NA hsa-miR-26b-5p ATM 0.885393662798425 3.2116297961629e-06 -0.694304374354523 1.11905560067279e-05 MirTarget -0.112936121726645 0.00532953311791061 NA NA NA hsa-miR-29a-5p ATM 1.46749674755271 3.34605004270294e-07 -0.694304374354523 1.11905560067279e-05 mirMAP -0.090317853164084 0.0012436877980901 NA NA NA hsa-miR-30c-5p ATM 0.778774633108 0.000285599212429136 -0.694304374354523 1.11905560067279e-05 mirMAP -0.107066600206639 0.00288450607513559 NA NA NA hsa-miR-324-5p ATM 2.95683728155095 1.32960514360912e-20 -0.694304374354523 1.11905560067279e-05 miRanda -0.111813212915851 1.04521240946738e-06 NA NA NA hsa-miR-335-3p ATM 3.08791651139852 5.31309869723517e-12 -0.694304374354523 1.11905560067279e-05 mirMAP -0.0514483956990691 0.00208293513833482 NA NA NA hsa-miR-339-5p ATM 2.68710938429893 3.03134080808154e-16 -0.694304374354523 1.11905560067279e-05 miRanda -0.0783740431328076 0.000503029149778795 NA NA NA hsa-miR-3607-3p ATM 2.68532138541128 5.66716351955047e-14 -0.694304374354523 1.11905560067279e-05 mirMAP -0.0786334626790037 0.00023741025400724 NA NA NA hsa-miR-362-3p ATM 2.0756816987665 3.89026064579331e-12 -0.694304374354523 1.11905560067279e-05 miRanda -0.112278812357676 1.35632724301173e-05 NA NA NA hsa-miR-421 ATM 1.17791565395543 6.78526676976629e-06 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda -0.0594136812739692 0.0431124517070599 NA NA NA hsa-miR-455-5p ATM 2.2582442061694 1.43472128037398e-13 -0.694304374354523 1.11905560067279e-05 miRanda -0.106749319544671 1.15313735793322e-05 NA NA NA hsa-miR-500a-5p ATM 1.72110365584658 3.0807246212659e-10 -0.694304374354523 1.11905560067279e-05 mirMAP -0.0999939776574252 0.000291244594703456 NA NA NA hsa-miR-576-5p ATM 2.20467023993664 3.4053475193793e-19 -0.694304374354523 1.11905560067279e-05 mirMAP -0.17622953753732 2.51071157737834e-09 NA NA NA hsa-miR-590-3p ATM 2.59289455139753 1.03200520972022e-21 -0.694304374354523 1.11905560067279e-05 miRanda;mirMAP -0.147925962529486 7.50176131513898e-08 NA NA NA hsa-miR-590-5p ATM 3.18300989862077 2.06813568597893e-26 -0.694304374354523 1.11905560067279e-05 mirMAP -0.155698076358082 1.697182104602e-10 NA NA NA hsa-miR-766-3p ATM 1.2456012547833 6.44584025471128e-06 -0.694304374354523 1.11905560067279e-05 MirTarget -0.0746375323911624 0.00704981671733787 NA NA NA hsa-miR-92a-3p ATM 2.06460102658973 1.44784291084757e-19 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate -0.174566583478402 5.02119051710453e-08 NA NA NA hsa-let-7a-5p BCL2 0.618599506841644 2.76973453058748e-05 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate -0.227211670110314 0.0179425982768944 24643702;26915294 Estrogen combined with progesterone decreases cell proliferation and inhibits the expression of Bcl 2 via microRNA let 7a and miR 34b in ovarian cancer cells; Moreover the relative abundance of Bcl-2 and microRNAs let-7a miR-34b expressions were detected by quantitative real-time PCR qRT-PCR and Western blotting; E2 + P4 promoted the expression of let-7a and miR-34b and reduced the expression of Bcl-2 in ovarian cancer cells; When the expression of let-7a or/and miR-34b was inhibited using miRNA inhibitors E2 + P4 treatment did not change the protein level of Bcl-2; E2 + P4 significantly inhibited the cell survival promoted the cell apoptosis induced the expression of let-7a and miR-34b and reduced the expression of Bcl-2 in ovarian cancer cells;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively poor survival;poor survival ovarian cancer;lung cancer hsa-miR-103a-3p BCL2 1.44083190496858 1.53799939616416e-13 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate -0.316592082591341 5.34263132858783e-06 NA NA NA hsa-miR-125a-5p BCL2 0.599529391575274 0.0102300147180307 -2.02088083891464 5.5300725103229e-13 PITA -0.204181839304005 0.000647180620809067 NA NA NA hsa-miR-126-5p BCL2 0.895338176458417 2.33372756450713e-05 -2.02088083891464 5.5300725103229e-13 mirMAP -0.136813897862068 0.0382651228386025 NA NA NA hsa-miR-130b-5p BCL2 2.9963110846538 1.98883029416455e-18 -2.02088083891464 5.5300725103229e-13 mirMAP -0.257233532043175 6.21636254360678e-11 27364335 The level of microRNA-130b in relationship with the expression of PPARγ VEGF-A BCL-2 and apoptosis were analyzed in 91 lung cancer patient samples using immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL assay on tissue microarrays; In vitro and in vivo miR-130b enrichment associated with down-regulation of PPARγ up-regulation of VEGF-A and BCL-2 and decreased apoptosis lung cancer hsa-miR-136-5p BCL2 2.09637138292451 1.50140005592201e-10 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.0848616871691006 0.0423848321932993 NA NA NA hsa-miR-15a-5p BCL2 2.34669284378787 1.69544424500258e-23 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.391979588821952 1.08722628903108e-12 25594541;26915294;18931683;25623762;22335947 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 ;poor survival;;drug resistance; breast cancer;lung cancer;prostate cancer;colon cancer;breast cancer hsa-miR-15b-3p BCL2 2.33847028227712 4.29662877950836e-19 -2.02088083891464 5.5300725103229e-13 mirMAP -0.323477257690888 1.09586549927814e-10 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-15b-5p BCL2 1.57112623124278 9.14247846750597e-13 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.256427911729671 3.30685638311642e-05 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-16-1-3p BCL2 2.56983217111073 3.02262181237943e-20 -2.02088083891464 5.5300725103229e-13 mirMAP -0.3266254366235 1.09255462667175e-11 18931683 MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2 prostate cancer hsa-miR-16-2-3p BCL2 2.31623086727196 4.29838149388188e-20 -2.02088083891464 5.5300725103229e-13 mirMAP -0.283819463467791 5.74174499512362e-08 NA NA NA hsa-miR-16-5p BCL2 1.75824877145857 1.68592440033108e-16 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.288487498854428 4.63144203616397e-06 21336967;24447552;18449891;25435430;24598659;18931683;22966344;25623762 P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells ;worse prognosis;drug resistance;;;;poor survival;drug resistance liver cancer;lymphoma;gastric cancer;lung cancer;lymphoma;prostate cancer;pancreatic cancer;colon cancer hsa-miR-17-5p BCL2 3.2710598467455 9.93128340539455e-27 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.293095808916295 2.47054725414332e-12 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-181a-5p BCL2 2.29556023480783 1.8138457900616e-21 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.302999442697681 2.70012636306699e-08 24267199;23740615;25524579;27534652;24335172 Bufalin was found to induce the expression of miR-181a a small non-coding RNA believed to induce apoptosis by repressing its target gene BCL-2; In prostate cancer PC-3cell line bufalin-induced apoptosis can be largely attenuated by a miR-181a inhibitor which blocked bufalin-induced Bcl-2 reduction and caspase-3 activation;The results from Western blotting indicated that miR-181a might be associated with the up-regulation of bcl-2 and matrix metalloproteinase 9 and the down-regulation of tissue inhibitor of metalloproteinases-3 and p21 in MG63 cells;Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression;In addition inhibition of miR-181a promoted apoptosis of HeLa and CaSKi cells due to increasing Bax expression and decreasing Bcl-2 expression;The function role of miR 181a in chemosensitivity to adriamycin by targeting Bcl 2 in low invasive breast cancer cells; Luciferase reporter vector with the putative BCL-2 3' untranslated region 3'UTR was constructed to explore whether BCL-2 was a direct target gene of miR-181a; Real-time PCR was performed to test the expression of miR-181a and Bcl-2 in the selected breast cancer tissue samples; Transfected with miR-181a mimic in cells resulted in the decreased expression of Bcl-2; At least in part the detection of miR-181a may direct the clinical medication in patients with neoadjuvant chemotherapy because of miR-181a enhanced adriamycin-induced apoptosis via targeting Bcl-2 ;;;; prostate cancer;sarcoma;lung squamous cell cancer;cervical and endocervical cancer;breast cancer hsa-miR-181b-5p BCL2 2.49307679431293 3.92829250217627e-20 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.305267910529038 2.57343031129337e-10 25524579 Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression lung squamous cell cancer hsa-miR-181c-5p BCL2 1.58587920618301 1.57506918816933e-10 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.112460550118007 0.0424640002427638 NA NA NA hsa-miR-181d-5p BCL2 1.52204912185579 9.2693319057748e-08 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.138340152158444 0.00425126630916248 NA NA NA hsa-miR-182-5p BCL2 3.53923166221814 5.07781258121574e-21 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;mirMAP -0.179869914139863 2.52267854475577e-07 23936432;26870290 Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR 182 and p21; Bcl2 and p21 were identified to be potential target genes of miR-182 in PC3 cells;The expression levels of B-cell lymphoma-2 Bcl-2 and microRNA-182 miR-182 were detected using western blot analysis and quantitative reverse transcription-polymerase chain reaction respectively; Mangiferin treatment was also able to significantly reduce Bcl-2 expression levels and enhance miR-182 expression in PC3 cells; Finally it was observed that mangiferin inhibited proliferation and induced apoptosis in PC3 human prostate cancer cells and this effect was correlated with downregulation of Bcl-2 and upregulation of miR-182 ; prostate cancer;B cell lymphoma hsa-miR-186-5p BCL2 1.47445398888668 3.0781726595413e-15 -2.02088083891464 5.5300725103229e-13 mirMAP -0.423453081728092 3.67590705887486e-09 NA NA NA hsa-miR-192-5p BCL2 2.69002528723195 1.22990188194432e-16 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate -0.208867066110207 3.33628652880772e-07 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-200a-5p BCL2 3.86316681673704 1.81076942093171e-15 -2.02088083891464 5.5300725103229e-13 mirMAP -0.15999187261028 4.28833785580744e-09 NA NA NA hsa-miR-200b-3p BCL2 3.78235093249346 3.18343003239465e-14 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;TargetScan;mirMAP -0.147905318391455 3.02424877197984e-08 NA NA NA hsa-miR-200b-5p BCL2 2.54484902707822 1.59240467582976e-06 -2.02088083891464 5.5300725103229e-13 mirMAP -0.136099351840362 2.8230250510626e-06 NA NA NA hsa-miR-200c-3p BCL2 3.50132673580082 2.42716349086937e-15 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;mirMAP -0.190113918290914 1.87463163361428e-10 NA NA NA hsa-miR-20a-3p BCL2 2.92621109947706 2.49504904635375e-17 -2.02088083891464 5.5300725103229e-13 mirMAP -0.210564396671593 8.96802878439544e-08 NA NA NA hsa-miR-20a-5p BCL2 3.15577933619191 4.19753346442454e-25 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.265706884379661 3.5423039457333e-10 NA NA NA hsa-miR-21-5p BCL2 2.73773305747971 1.38864982139576e-43 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.366618885310627 5.78881699391161e-09 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-215-5p BCL2 2.30755467422978 2.38476032118039e-06 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate -0.0826069551217565 0.00440672930203777 NA NA NA hsa-miR-224-3p BCL2 1.87536386559317 6.15140969394846e-05 -2.02088083891464 5.5300725103229e-13 mirMAP -0.0990023017290901 0.00135017541164802 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-224-5p BCL2 2.94107125335675 5.72194099515157e-08 -2.02088083891464 5.5300725103229e-13 mirMAP -0.119749067233376 1.76067406110872e-06 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-24-2-5p BCL2 2.07171035460647 3.15853539996136e-16 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.329656547931865 2.75296639271459e-10 NA NA NA hsa-miR-29a-5p BCL2 1.46749674755271 3.34605004270294e-07 -2.02088083891464 5.5300725103229e-13 mirMAP -0.213517369621975 2.31345511002058e-05 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29b-3p BCL2 1.65828197923813 1.02676780888141e-09 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.296891319533915 2.28427123681482e-09 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-3065-5p BCL2 2.74629919868982 1.86846589298284e-08 -2.02088083891464 5.5300725103229e-13 mirMAP -0.154823847891893 5.79242637365127e-06 NA NA NA hsa-miR-32-3p BCL2 2.02436999565685 5.94091197945307e-09 -2.02088083891464 5.5300725103229e-13 mirMAP -0.20244441600453 5.71853892832186e-06 NA NA NA hsa-miR-335-3p BCL2 3.08791651139852 5.31309869723517e-12 -2.02088083891464 5.5300725103229e-13 mirMAP -0.104382164677445 0.000555265264147089 NA NA NA hsa-miR-33a-5p BCL2 3.79671563098419 1.15966309820345e-18 -2.02088083891464 5.5300725103229e-13 mirMAP -0.197338268783918 2.87180137117656e-09 NA NA NA hsa-miR-34a-5p BCL2 1.9016323452565 1.43092834643601e-14 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.313298897109154 6.78995714898249e-09 24565525;23155233;24444609;20687223;22623155;24988056;18803879;19714243;25053345;20433755;21399894;22964582;23862748 In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression drug resistance;;poor survival;drug resistance;;;poor survival;differentiation;poor survival;drug resistance;;;; breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;breast cancer;gastric cancer;gastric cancer;pancreatic cancer;prostate cancer;colon cancer;breast cancer;lung cancer;liver cancer hsa-miR-365a-3p BCL2 -0.0388985816963467 0.859114494267351 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.26287248585935 3.91090481330584e-05 NA NA NA hsa-miR-429 BCL2 4.48815175680773 2.44117492218206e-17 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;PITA;mirMAP -0.154017674076185 5.15216313360141e-10 23999873;26513239;26511969 MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation ;; esophageal cancer;gastric cancer;glioblastoma hsa-miR-450b-5p BCL2 1.69244418548325 1.68064054148881e-10 -2.02088083891464 5.5300725103229e-13 mirMAP -0.195491457721654 0.000146490668566645 NA NA NA hsa-miR-452-5p BCL2 1.37180058737183 0.00171494843537772 -2.02088083891464 5.5300725103229e-13 mirMAP -0.104092924779063 0.00100591652628657 NA NA NA hsa-miR-455-5p BCL2 2.2582442061694 1.43472128037398e-13 -2.02088083891464 5.5300725103229e-13 mirMAP -0.296135324171891 8.75003372187937e-12 NA NA NA hsa-miR-582-5p BCL2 0.609226359812689 0.032988717891497 -2.02088083891464 5.5300725103229e-13 PITA -0.211866972823695 1.29345936711211e-05 NA NA NA hsa-miR-590-3p BCL2 2.59289455139753 1.03200520972022e-21 -2.02088083891464 5.5300725103229e-13 miRanda;mirMAP -0.268687896594515 6.89769791912093e-08 NA NA NA hsa-miR-590-5p BCL2 3.18300989862077 2.06813568597893e-26 -2.02088083891464 5.5300725103229e-13 miRanda -0.311666149337473 1.27642835632825e-12 NA NA NA hsa-miR-629-5p BCL2 2.10182419359635 1.51788571125757e-15 -2.02088083891464 5.5300725103229e-13 mirMAP -0.237720791875816 2.9555469743804e-06 NA NA NA hsa-miR-664a-5p BCL2 0.505019913598436 0.032933350691651 -2.02088083891464 5.5300725103229e-13 mirMAP -0.133435367665978 0.0249936816629116 NA NA NA hsa-miR-7-1-3p BCL2 1.84950311431067 1.25300363397654e-13 -2.02088083891464 5.5300725103229e-13 mirMAP -0.256930851687325 1.96074632615661e-06 NA NA NA hsa-miR-7-5p BCL2 2.28980165299999 1.5131097560452e-07 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;mirMAP -0.178441327891617 1.03482718248784e-07 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-miR-96-5p BCL2 4.89433085814374 1.92000659886961e-31 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;TargetScan -0.202123113149013 6.78873155803595e-11 NA NA NA hsa-miR-34a-5p BIRC3 1.9016323452565 1.43092834643601e-14 -1.14878434773067 0.00715931622274468 miRNAWalker2_validate -0.217054924716933 0.00780122048146313 NA NA NA hsa-miR-651-5p BIRC3 2.32951837918862 1.62508965949028e-11 -1.14878434773067 0.00715931622274468 MirTarget -0.407201062114202 3.04074465541569e-10 NA NA NA hsa-miR-664a-3p BIRC3 0.634721925861133 0.00520070178640421 -1.14878434773067 0.00715931622274468 mirMAP -0.30056739615358 0.00101453991329218 NA NA NA hsa-miR-98-5p BIRC3 1.11154309866014 1.24143909012085e-08 -1.14878434773067 0.00715931622274468 miRNAWalker2_validate -0.732739588263987 1.05214961960018e-12 NA NA NA hsa-miR-140-5p CAPN1 0.844753502512594 3.73722278438606e-05 0.551088466286071 0.000662289657689611 miRanda;miRNATAP -0.0910488640089849 0.0177890103238609 NA NA NA hsa-miR-491-5p CAPN1 0.615770352820862 0.0418295628761654 0.551088466286071 0.000662289657689611 miRanda -0.0575224474843367 0.0394049148138824 NA NA NA hsa-miR-101-3p CAPN2 0.522819989585461 0.00375627731618038 -0.422341253524924 0.0913287396375096 miRNAWalker2_validate;MirTarget -0.50384520654326 1.83370655936121e-14 NA NA NA hsa-miR-107 CAPN2 1.30977326593435 1.30372468603965e-11 -0.422341253524924 0.0913287396375096 miRanda -0.437052765176765 3.2546933497498e-13 NA NA NA hsa-miR-1468-5p CAPN2 0.0469536064343461 0.881810795145912 -0.422341253524924 0.0913287396375096 MirTarget -0.232939493923959 7.04451041151474e-10 NA NA NA hsa-miR-20a-3p CAPN2 2.92621109947706 2.49504904635375e-17 -0.422341253524924 0.0913287396375096 MirTarget -0.115847953441966 0.000784753626422282 NA NA NA hsa-miR-320a CAPN2 0.438165828017084 0.0390159073347133 -0.422341253524924 0.0913287396375096 miRanda -0.277145040818614 1.10455221350909e-06 NA NA NA hsa-miR-320b CAPN2 1.55692969039548 1.41071034251915e-08 -0.422341253524924 0.0913287396375096 miRanda -0.172007383267619 6.96931261650163e-05 NA NA NA hsa-miR-33a-3p CAPN2 1.72765312072219 1.51784443453521e-07 -0.422341253524924 0.0913287396375096 mirMAP -0.270141056401029 4.05112944673904e-12 NA NA NA hsa-miR-421 CAPN2 1.17791565395543 6.78526676976629e-06 -0.422341253524924 0.0913287396375096 miRanda -0.251126865613037 3.2279294019974e-08 NA NA NA hsa-miR-590-3p CAPN2 2.59289455139753 1.03200520972022e-21 -0.422341253524924 0.0913287396375096 miRanda -0.14408856443896 0.00096528080440921 NA NA NA hsa-miR-590-5p CAPN2 3.18300989862077 2.06813568597893e-26 -0.422341253524924 0.0913287396375096 miRanda -0.158328870843835 4.56868205430932e-05 NA NA NA hsa-miR-129-5p CASP10 -0.524170159980738 0.222582956006346 0.0928615128292813 0.717578504954206 mirMAP -0.0853411379353378 0.00369536196704936 NA NA NA hsa-miR-19a-3p CASP10 3.42309334186656 3.02671914353412e-28 0.0928615128292813 0.717578504954206 MirTarget;mirMAP -0.0760692924707616 0.0420182085082128 NA NA NA hsa-miR-217 CASP10 0.608024397387488 0.199352491710517 0.0928615128292813 0.717578504954206 mirMAP -0.060163005705642 0.0254636246766209 NA NA NA hsa-miR-33a-3p CASP10 1.72765312072219 1.51784443453521e-07 0.0928615128292813 0.717578504954206 mirMAP -0.104979467957295 0.0102694577013009 NA NA NA hsa-miR-374a-3p CASP10 0.533309330504947 0.00192918429705142 0.0928615128292813 0.717578504954206 mirMAP -0.20364512927735 0.00522441741668315 NA NA NA hsa-miR-421 CASP10 1.17791565395543 6.78526676976629e-06 0.0928615128292813 0.717578504954206 mirMAP -0.157687882200134 0.000810622936052014 NA NA NA hsa-miR-592 CASP10 1.51765968871077 0.000636335248013204 0.0928615128292813 0.717578504954206 miRNATAP -0.0607280316017113 0.0319774348592027 NA NA NA hsa-miR-744-3p CASP10 2.7517405670917 4.22040908411227e-14 0.0928615128292813 0.717578504954206 mirMAP -0.141817879498213 1.49202617610436e-05 NA NA NA hsa-miR-195-3p CASP3 -0.658653229922836 0.0142127125129199 0.535535897161408 4.31594916615815e-05 MirTarget -0.0535627235455014 0.0267330415592061 NA NA NA hsa-miR-335-5p CASP7 1.77247705492746 2.22457658872091e-06 0.211539196871581 0.203476830450442 MirTarget -0.0719742808793655 0.000654118920465733 NA NA NA hsa-miR-143-3p CASP8 -2.5789192793377 1.55518999614836e-14 0.614672266065446 0.00102927275063291 MirTarget -0.0916491418973378 0.000456611797712721 NA NA NA hsa-miR-217 CASP8 0.608024397387488 0.199352491710517 0.614672266065446 0.00102927275063291 miRanda -0.0900129994456467 4.15377062363525e-06 NA NA NA hsa-miR-125b-2-3p CASP9 -1.83175829351767 2.94917958974528e-05 -0.446359927280876 0.00400976702291555 mirMAP -0.0673957165633185 9.18982536656168e-05 NA NA NA hsa-miR-193b-3p CASP9 2.25711804611899 4.1940744806631e-14 -0.446359927280876 0.00400976702291555 miRNAWalker2_validate -0.0905760962799774 0.00019445516044014 NA NA NA hsa-miR-199a-3p CASP9 0.640600337515787 0.0380326905134914 -0.446359927280876 0.00400976702291555 mirMAP -0.146082132838509 1.00313136531724e-09 23319430 The techniques used were the MTT assay flow cytometry real-time PCR to assess miR-199a expression as also caspase-8 and caspase-9 activity in HepG2 cells treated with Propofol liver cancer hsa-miR-199b-3p CASP9 0.643923492750702 0.0371742251925406 -0.446359927280876 0.00400976702291555 mirMAP -0.146136089499986 9.60609442207656e-10 NA NA NA hsa-miR-222-5p CASP9 1.25632771414778 0.000138653440511922 -0.446359927280876 0.00400976702291555 mirMAP -0.126831808191525 1.31064720813193e-08 NA NA NA hsa-miR-424-5p CASP9 1.61930224569578 1.89642549274994e-10 -0.446359927280876 0.00400976702291555 mirMAP -0.0659642623796356 0.0232208202467714 NA NA NA hsa-miR-7-5p CASP9 2.28980165299999 1.5131097560452e-07 -0.446359927280876 0.00400976702291555 miRNAWalker2_validate -0.0673187144793968 0.000217848216304623 NA NA NA hsa-miR-103a-2-5p CFLAR 2.47599305985086 7.933028987326e-11 -0.231925856222684 0.202844044313639 mirMAP -0.0666589592747516 0.00909550762581571 NA NA NA hsa-miR-107 CFLAR 1.30977326593435 1.30372468603965e-11 -0.231925856222684 0.202844044313639 miRanda -0.148357712217052 0.000900731169471226 NA NA NA hsa-miR-125a-5p CFLAR 0.599529391575274 0.0102300147180307 -0.231925856222684 0.202844044313639 miRanda -0.225494307449277 1.29185039963355e-09 NA NA NA hsa-miR-130b-3p CFLAR 3.5350292994509 1.73934183852569e-27 -0.231925856222684 0.202844044313639 mirMAP -0.145696928019461 4.93456456035999e-09 NA NA NA hsa-miR-15b-5p CFLAR 1.57112623124278 9.14247846750597e-13 -0.231925856222684 0.202844044313639 mirMAP -0.101026335268494 0.00988724932214317 NA NA NA hsa-miR-186-5p CFLAR 1.47445398888668 3.0781726595413e-15 -0.231925856222684 0.202844044313639 mirMAP -0.161290321910154 0.000432850514170424 NA NA NA hsa-miR-2110 CFLAR 1.16625590651194 6.4784195289885e-05 -0.231925856222684 0.202844044313639 MirTarget -0.0902714497028716 0.00504188584599931 NA NA NA hsa-miR-301a-3p CFLAR 2.81024345929638 2.29784847962242e-17 -0.231925856222684 0.202844044313639 mirMAP -0.168172963252665 2.02871497274292e-10 NA NA NA hsa-miR-30b-3p CFLAR 0.834142820354026 0.000972582820878813 -0.231925856222684 0.202844044313639 mirMAP -0.176108209676801 3.44450275553177e-07 NA NA NA hsa-miR-320a CFLAR 0.438165828017084 0.0390159073347133 -0.231925856222684 0.202844044313639 miRanda -0.187083028324921 6.26248969577351e-06 NA NA NA hsa-miR-320b CFLAR 1.55692969039548 1.41071034251915e-08 -0.231925856222684 0.202844044313639 miRanda -0.0850224093827846 0.00710261250326669 NA NA NA hsa-miR-421 CFLAR 1.17791565395543 6.78526676976629e-06 -0.231925856222684 0.202844044313639 miRanda -0.14658086248006 1.02286863777652e-05 NA NA NA hsa-miR-454-3p CFLAR 2.47234127820054 1.12878018736016e-21 -0.231925856222684 0.202844044313639 mirMAP -0.118171420962222 0.000376451937569571 NA NA NA hsa-miR-484 CFLAR 1.81844463411787 1.82951571230938e-15 -0.231925856222684 0.202844044313639 mirMAP -0.145571572520698 9.02314434337118e-05 NA NA NA hsa-miR-148a-3p CHUK 1.26728238710376 2.52325607402829e-06 -0.123960303858583 0.302722046952969 MirTarget -0.0701344163836406 0.000974309950716782 NA NA NA hsa-miR-15a-5p CHUK 2.34669284378787 1.69544424500258e-23 -0.123960303858583 0.302722046952969 miRNAWalker2_validate;miRTarBase;MirTarget -0.0500289622248936 0.0328799661580439 NA NA NA hsa-miR-195-5p CHUK -1.44753678070504 8.70594292149271e-09 -0.123960303858583 0.302722046952969 miRNAWalker2_validate;MirTarget -0.0517847125621791 0.0226582563449759 NA NA NA hsa-miR-23b-3p CHUK -0.251132426825047 0.150200321210792 -0.123960303858583 0.302722046952969 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.0766789350678081 0.0228889504061852 NA NA NA hsa-miR-29b-2-5p CHUK 0.910668640983475 0.00666655585493488 -0.123960303858583 0.302722046952969 MirTarget -0.105463511044412 4.36313837727314e-10 NA NA NA hsa-miR-497-5p CHUK 0.0257087130056286 0.918145413833358 -0.123960303858583 0.302722046952969 MirTarget -0.130303574602807 1.33264117705817e-08 NA NA NA hsa-miR-125a-5p CSF2RB 0.599529391575274 0.0102300147180307 -0.739086291347396 0.0696045958228138 miRanda -0.426358007692611 3.75324813924671e-07 NA NA NA hsa-miR-15b-3p CSF2RB 2.33847028227712 4.29662877950836e-19 -0.739086291347396 0.0696045958228138 mirMAP -0.410621118990345 8.08744457322504e-09 NA NA NA hsa-miR-181b-5p CSF2RB 2.49307679431293 3.92829250217627e-20 -0.739086291347396 0.0696045958228138 MirTarget -0.199878586632952 0.0040462000934792 NA NA NA hsa-miR-181c-5p CSF2RB 1.58587920618301 1.57506918816933e-10 -0.739086291347396 0.0696045958228138 MirTarget -0.192897492889798 0.0137082096418576 NA NA NA hsa-miR-181d-5p CSF2RB 1.52204912185579 9.2693319057748e-08 -0.739086291347396 0.0696045958228138 MirTarget -0.305318018697499 6.94331838017145e-06 NA NA NA hsa-miR-186-5p CSF2RB 1.47445398888668 3.0781726595413e-15 -0.739086291347396 0.0696045958228138 mirMAP -0.36439054422735 0.000394153164171476 NA NA NA hsa-miR-19a-3p CSF2RB 3.42309334186656 3.02671914353412e-28 -0.739086291347396 0.0696045958228138 MirTarget -0.217107868095224 0.00024429476771933 NA NA NA hsa-miR-19b-3p CSF2RB 2.49529833021187 1.57028265846699e-23 -0.739086291347396 0.0696045958228138 MirTarget -0.339753464615837 5.03583434435228e-06 NA NA NA hsa-miR-30b-3p CSF2RB 0.834142820354026 0.000972582820878813 -0.739086291347396 0.0696045958228138 MirTarget -0.473179222241933 7.9171965820414e-10 NA NA NA hsa-miR-452-3p CSF2RB 2.42521958420768 4.08754552781156e-07 -0.739086291347396 0.0696045958228138 mirMAP -0.135652814910086 0.000851140820930795 NA NA NA hsa-miR-532-5p CSF2RB 1.55697650978597 1.57884735535196e-11 -0.739086291347396 0.0696045958228138 MirTarget -0.208350232426084 0.0129885839785501 NA NA NA hsa-miR-576-5p CSF2RB 2.20467023993664 3.4053475193793e-19 -0.739086291347396 0.0696045958228138 miRNATAP -0.289248506739264 0.000161113961006424 NA NA NA hsa-miR-145-5p DFFA -1.55259331973517 9.97889123247165e-07 0.401133064314179 0.000349148153504863 miRNAWalker2_validate;miRTarBase -0.0613743876259081 0.000270529331870507 NA NA NA hsa-miR-199a-5p DFFB 0.592984035153911 0.0674836634175293 0.808547923724971 3.00427717245982e-08 miRanda -0.0688499379877952 0.00179014565267308 NA NA NA hsa-miR-199b-5p DFFB 0.218704279044827 0.519493319158441 0.808547923724971 3.00427717245982e-08 miRanda -0.0509207371934235 0.0159710867137279 NA NA NA hsa-miR-365a-3p DFFB -0.0388985816963467 0.859114494267351 0.808547923724971 3.00427717245982e-08 MirTarget -0.112300683568728 0.000635832870706886 NA NA NA hsa-miR-129-5p ENDOD1 -0.524170159980738 0.222582956006346 -0.331902287589133 0.146465367778401 MirTarget;miRanda -0.101557070119569 9.90829354086753e-05 NA NA NA hsa-miR-130b-3p ENDOD1 3.5350292994509 1.73934183852569e-27 -0.331902287589133 0.146465367778401 MirTarget -0.135527686049539 1.78733250260079e-05 NA NA NA hsa-miR-16-1-3p ENDOD1 2.56983217111073 3.02262181237943e-20 -0.331902287589133 0.146465367778401 mirMAP -0.176726234672374 4.76351781243037e-06 NA NA NA hsa-miR-181a-5p ENDOD1 2.29556023480783 1.8138457900616e-21 -0.331902287589133 0.146465367778401 MirTarget -0.0971248096504928 0.026632641597437 NA NA NA hsa-miR-181b-5p ENDOD1 2.49307679431293 3.92829250217627e-20 -0.331902287589133 0.146465367778401 MirTarget -0.0866691622342756 0.0263459095458543 NA NA NA hsa-miR-181c-5p ENDOD1 1.58587920618301 1.57506918816933e-10 -0.331902287589133 0.146465367778401 MirTarget -0.181825067072814 2.96443076151955e-05 NA NA NA hsa-miR-181d-5p ENDOD1 1.52204912185579 9.2693319057748e-08 -0.331902287589133 0.146465367778401 MirTarget -0.151516261359878 7.10308197865111e-05 NA NA NA hsa-miR-192-5p ENDOD1 2.69002528723195 1.22990188194432e-16 -0.331902287589133 0.146465367778401 miRNAWalker2_validate -0.157492739481784 1.21322938151644e-06 NA NA NA hsa-miR-19a-3p ENDOD1 3.42309334186656 3.02671914353412e-28 -0.331902287589133 0.146465367778401 mirMAP -0.138604025645659 2.7728778889914e-05 NA NA NA hsa-miR-19b-3p ENDOD1 2.49529833021187 1.57028265846699e-23 -0.331902287589133 0.146465367778401 mirMAP -0.189604053563397 5.4551020074105e-06 NA NA NA hsa-miR-200b-3p ENDOD1 3.78235093249346 3.18343003239465e-14 -0.331902287589133 0.146465367778401 TargetScan -0.0993963756164199 2.89212715552139e-06 NA NA NA hsa-miR-20a-3p ENDOD1 2.92621109947706 2.49504904635375e-17 -0.331902287589133 0.146465367778401 MirTarget -0.114606991724655 0.000269835101992473 NA NA NA hsa-miR-26b-3p ENDOD1 2.18464160365372 2.11543189388328e-18 -0.331902287589133 0.146465367778401 mirMAP -0.136637022611884 0.00131032309806543 NA NA NA hsa-miR-301a-3p ENDOD1 2.81024345929638 2.29784847962242e-17 -0.331902287589133 0.146465367778401 MirTarget -0.134710930709202 6.44707125829365e-05 NA NA NA hsa-miR-3607-3p ENDOD1 2.68532138541128 5.66716351955047e-14 -0.331902287589133 0.146465367778401 MirTarget;miRNATAP -0.108599729502635 0.000404026567759276 NA NA NA hsa-miR-361-5p ENDOD1 0.971859117235239 5.30236555707088e-09 -0.331902287589133 0.146465367778401 MirTarget;miRanda -0.339022925897406 2.25093949414901e-07 NA NA NA hsa-miR-3613-5p ENDOD1 2.64358387329263 1.0373753017245e-24 -0.331902287589133 0.146465367778401 MirTarget -0.172750734082545 3.09318154778455e-05 NA NA NA hsa-miR-429 ENDOD1 4.48815175680773 2.44117492218206e-17 -0.331902287589133 0.146465367778401 miRanda;miRNATAP -0.0888835539583952 7.43247312270928e-06 NA NA NA hsa-miR-450b-5p ENDOD1 1.69244418548325 1.68064054148881e-10 -0.331902287589133 0.146465367778401 MirTarget;mirMAP -0.0870651294112237 0.0337148188369448 NA NA NA hsa-miR-454-3p ENDOD1 2.47234127820054 1.12878018736016e-21 -0.331902287589133 0.146465367778401 MirTarget -0.199178296032197 1.5946167513499e-06 NA NA NA hsa-miR-590-3p ENDOD1 2.59289455139753 1.03200520972022e-21 -0.331902287589133 0.146465367778401 miRanda -0.150399397562406 0.00015650300787438 NA NA NA hsa-miR-199a-5p EXOG 0.592984035153911 0.0674836634175293 0.140143801213435 0.400245351651598 miRanda -0.0722912928683034 0.00351903545423481 NA NA NA hsa-miR-24-3p EXOG 0.99989036772428 1.35595013650376e-07 0.140143801213435 0.400245351651598 MirTarget -0.0949040516743045 0.0248084041148335 NA NA NA hsa-let-7a-5p FAS 0.618599506841644 2.76973453058748e-05 -0.893121037137088 0.00675655818216232 TargetScan -0.294996828851615 0.0073114418152214 NA NA NA hsa-miR-106a-5p FAS 2.48882002962836 1.99757727374521e-12 -0.893121037137088 0.00675655818216232 miRNAWalker2_validate;miRTarBase -0.286433262215431 2.93487884151059e-11 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-23b-3p FAS -0.251132426825047 0.150200321210792 -0.893121037137088 0.00675655818216232 miRNATAP -0.391116610184141 2.37246599324584e-05 24356489 Moreover over-expression of Fas rescued the pro-proliferation effect of miR-23 indicating Fas is a direct mediator of miR-23 functions; Furthermore contrast to miR-23a/b which was up regulated the Fas expression level was down-regulated and inversely correlated with miR-23 in split radiation induced lymphoma tissue samples; Finally our data also indicates that miR-23a could repress Fas much more potent than miR-23b and the additional region besides conserved seed pairing enables miR-23a's higher regulation lymphoma hsa-miR-361-5p FAS 0.971859117235239 5.30236555707088e-09 -0.893121037137088 0.00675655818216232 miRanda -0.765596610913641 1.34005865686507e-16 NA NA NA hsa-miR-491-5p FAS 0.615770352820862 0.0418295628761654 -0.893121037137088 0.00675655818216232 miRanda -0.202143347610942 0.000355416125267629 NA NA NA hsa-miR-590-5p FAS 3.18300989862077 2.06813568597893e-26 -0.893121037137088 0.00675655818216232 miRanda -0.26445516527792 2.22188286955534e-07 NA NA NA hsa-miR-98-5p FAS 1.11154309866014 1.24143909012085e-08 -0.893121037137088 0.00675655818216232 miRNAWalker2_validate -0.770550954607501 1.78193866759893e-23 NA NA NA hsa-let-7e-5p FASLG 0.860104282510173 6.04758298373779e-05 -0.196180452389551 0.711804379159628 miRNATAP -0.681095573446369 7.73237301751494e-09 NA NA NA hsa-miR-324-5p FASLG 2.95683728155095 1.32960514360912e-20 -0.196180452389551 0.711804379159628 miRanda -0.190742358117509 0.0133843611744564 NA NA NA hsa-miR-146b-5p IKBKB 1.75587235896724 1.15724631266659e-07 -0.00227190214342876 0.988714147115007 miRanda -0.12253940493918 7.13410135054121e-08 NA NA NA hsa-miR-199a-5p IKBKB 0.592984035153911 0.0674836634175293 -0.00227190214342876 0.988714147115007 miRNAWalker2_validate;miRTarBase;miRanda;miRNATAP -0.0902751790213246 0.000147075149625618 NA NA NA hsa-miR-369-3p IKBKB 0.946781510019564 0.00134850306966842 -0.00227190214342876 0.988714147115007 miRNATAP -0.0981847866010809 0.00016908054674169 NA NA NA hsa-miR-107 IKBKG 1.30977326593435 1.30372468603965e-11 0.412355551213307 0.00132920442221218 miRanda -0.0831926768626085 0.00863713795776225 NA NA NA hsa-miR-143-3p IKBKG -2.5789192793377 1.55518999614836e-14 0.412355551213307 0.00132920442221218 mirMAP -0.0507873884733058 0.00461428633244773 NA NA NA hsa-miR-432-5p IKBKG -0.128200716359323 0.676832757701632 0.412355551213307 0.00132920442221218 mirMAP -0.0603898010677136 0.00305252418998825 NA NA NA hsa-miR-30d-3p IL1B 0.977747550180601 4.3048212205381e-05 0.039301070315787 0.942663363341787 MirTarget -0.351425913519885 0.00142656977660209 NA NA NA hsa-miR-130b-5p IL1R1 2.9963110846538 1.98883029416455e-18 -0.754392858754991 0.00819157634786962 mirMAP -0.265810866002561 8.60645196440847e-12 NA NA NA hsa-miR-17-3p IL1R1 2.2704817679209 1.1667437320211e-22 -0.754392858754991 0.00819157634786962 mirMAP -0.457437413596706 7.7813507528449e-17 NA NA NA hsa-miR-181b-5p IL1R1 2.49307679431293 3.92829250217627e-20 -0.754392858754991 0.00819157634786962 mirMAP -0.144149390460215 0.00312034364681948 NA NA NA hsa-miR-186-5p IL1R1 1.47445398888668 3.0781726595413e-15 -0.754392858754991 0.00819157634786962 mirMAP -0.413980327390447 6.22085295917803e-09 NA NA NA hsa-miR-192-5p IL1R1 2.69002528723195 1.22990188194432e-16 -0.754392858754991 0.00819157634786962 miRNAWalker2_validate -0.18623904564978 4.77161512216095e-06 NA NA NA hsa-miR-197-3p IL1R1 1.75733174019505 8.88576793100499e-13 -0.754392858754991 0.00819157634786962 miRNAWalker2_validate -0.245286619557537 6.97172291808552e-06 NA NA NA hsa-miR-215-5p IL1R1 2.30755467422978 2.38476032118039e-06 -0.754392858754991 0.00819157634786962 miRNAWalker2_validate -0.0751298193576192 0.00907325730526252 NA NA NA hsa-miR-24-3p IL1R1 0.99989036772428 1.35595013650376e-07 -0.754392858754991 0.00819157634786962 miRNATAP -0.329790317110319 4.8735388331152e-06 NA NA NA hsa-miR-26b-5p IL1R1 0.885393662798425 3.2116297961629e-06 -0.754392858754991 0.00819157634786962 mirMAP -0.287058738544535 7.46900640431975e-05 NA NA NA hsa-miR-30d-3p IL1R1 0.977747550180601 4.3048212205381e-05 -0.754392858754991 0.00819157634786962 mirMAP -0.207730148083987 0.000312780009684164 NA NA NA hsa-miR-335-3p IL1R1 3.08791651139852 5.31309869723517e-12 -0.754392858754991 0.00819157634786962 mirMAP -0.128248188751599 1.75690264294768e-05 NA NA NA hsa-miR-361-5p IL1R1 0.971859117235239 5.30236555707088e-09 -0.754392858754991 0.00819157634786962 miRanda -0.498319115587793 9.79775892914811e-10 NA NA NA hsa-miR-491-5p IL1R1 0.615770352820862 0.0418295628761654 -0.754392858754991 0.00819157634786962 miRanda -0.0967007012442384 0.0494251813743173 NA NA NA hsa-miR-590-3p IL1R1 2.59289455139753 1.03200520972022e-21 -0.754392858754991 0.00819157634786962 miRanda;miRNATAP -0.268420918425037 5.48871203423167e-08 NA NA NA hsa-miR-944 IL1R1 2.91186649218281 1.31574753528144e-06 -0.754392858754991 0.00819157634786962 mirMAP -0.118403143401936 3.14768683036805e-07 NA NA NA hsa-miR-106a-5p IL1RAP 2.48882002962836 1.99757727374521e-12 0.687376288697117 0.0561773808581464 MirTarget -0.184285524641675 0.000113235346123953 NA NA NA hsa-miR-106b-5p IL1RAP 2.46782146831112 1.36171495805632e-23 0.687376288697117 0.0561773808581464 MirTarget -0.308359753412902 3.66029994017838e-06 NA NA NA hsa-miR-107 IL1RAP 1.30977326593435 1.30372468603965e-11 0.687376288697117 0.0561773808581464 miRanda -0.33678389768747 0.000139724034766597 NA NA NA hsa-miR-130b-3p IL1RAP 3.5350292994509 1.73934183852569e-27 0.687376288697117 0.0561773808581464 MirTarget -0.147309793399794 0.00330158193001679 NA NA NA hsa-miR-139-5p IL1RAP -1.52606598644743 1.20474151350665e-08 0.687376288697117 0.0561773808581464 miRanda -0.216871073158647 0.000708940318255466 NA NA NA hsa-miR-186-5p IL1RAP 1.47445398888668 3.0781726595413e-15 0.687376288697117 0.0561773808581464 mirMAP -0.248147291056268 0.0064761570270495 NA NA NA hsa-miR-190a-5p IL1RAP 0.762748400660219 0.0035950590410453 0.687376288697117 0.0561773808581464 MirTarget -0.193022328361973 0.00385457164001993 NA NA NA hsa-miR-192-5p IL1RAP 2.69002528723195 1.22990188194432e-16 0.687376288697117 0.0561773808581464 miRNAWalker2_validate -0.203023264982205 7.92657993381149e-05 NA NA NA hsa-miR-20b-5p IL1RAP 2.07706563022469 1.10107236083433e-05 0.687376288697117 0.0561773808581464 MirTarget -0.178499755018748 7.64252091780409e-07 NA NA NA hsa-miR-215-5p IL1RAP 2.30755467422978 2.38476032118039e-06 0.687376288697117 0.0561773808581464 miRNAWalker2_validate -0.140484900749653 9.91578317658242e-05 NA NA NA hsa-miR-29c-3p IL1RAP -0.00968972577705429 0.97099586346872 0.687376288697117 0.0561773808581464 MirTarget;miRNATAP -0.316780772059122 1.15292735023863e-06 NA NA NA hsa-miR-301a-3p IL1RAP 2.81024345929638 2.29784847962242e-17 0.687376288697117 0.0561773808581464 MirTarget -0.151958204710121 0.00446392491079674 NA NA NA hsa-miR-320a IL1RAP 0.438165828017084 0.0390159073347133 0.687376288697117 0.0561773808581464 MirTarget;PITA;miRanda -0.190631832000772 0.0213993725591207 NA NA NA hsa-miR-335-3p IL1RAP 3.08791651139852 5.31309869723517e-12 0.687376288697117 0.0561773808581464 mirMAP -0.116498433237795 0.00206868835534839 NA NA NA hsa-miR-361-5p IL1RAP 0.971859117235239 5.30236555707088e-09 0.687376288697117 0.0561773808581464 miRanda -0.278506548425349 0.00771310516085455 NA NA NA hsa-miR-421 IL1RAP 1.17791565395543 6.78526676976629e-06 0.687376288697117 0.0561773808581464 MirTarget;miRanda -0.191353033681468 0.00390232735089893 NA NA NA hsa-miR-454-3p IL1RAP 2.47234127820054 1.12878018736016e-21 0.687376288697117 0.0561773808581464 MirTarget -0.134476368406855 0.0422897667701867 NA NA NA hsa-miR-664a-3p IL1RAP 0.634721925861133 0.00520070178640421 0.687376288697117 0.0561773808581464 mirMAP -0.367234968888842 1.50065370650936e-06 NA NA NA hsa-miR-93-5p IL1RAP 3.03961860136032 1.11672209617395e-24 0.687376288697117 0.0561773808581464 MirTarget -0.289274250215671 1.35967607397858e-07 NA NA NA hsa-miR-1226-3p IRAK1 1.38118928579963 0.000205503474787488 0.6373544526515 0.00032590064915133 miRNAWalker2_validate -0.106240098169623 4.99256151870902e-05 NA NA NA hsa-miR-328-3p IRAK1 0.596804159297544 0.013858523511843 0.6373544526515 0.00032590064915133 miRNAWalker2_validate -0.0847980967833339 0.0175213264803641 NA NA NA hsa-miR-141-3p IRAK3 5.02396127982626 2.19224509139725e-24 -1.61324599744624 9.44362061411831e-07 mirMAP -0.237412262860539 1.63026403262395e-15 NA NA NA hsa-miR-148b-5p IRAK3 2.18024067300781 2.84770452413262e-14 -1.61324599744624 9.44362061411831e-07 mirMAP -0.337307253672073 2.92190660652579e-09 NA NA NA hsa-miR-16-1-3p IRAK3 2.56983217111073 3.02262181237943e-20 -1.61324599744624 9.44362061411831e-07 mirMAP -0.217915579974644 0.000117601397835657 NA NA NA hsa-miR-16-2-3p IRAK3 2.31623086727196 4.29838149388188e-20 -1.61324599744624 9.44362061411831e-07 mirMAP -0.241605828325225 7.32339791852684e-05 NA NA NA hsa-miR-16-5p IRAK3 1.75824877145857 1.68592440033108e-16 -1.61324599744624 9.44362061411831e-07 miRNAWalker2_validate -0.294716229106297 5.37676785444093e-05 NA NA NA hsa-miR-186-5p IRAK3 1.47445398888668 3.0781726595413e-15 -1.61324599744624 9.44362061411831e-07 mirMAP -0.520105007237852 3.24671297125945e-10 NA NA NA hsa-miR-188-5p IRAK3 2.52825126596644 6.78099435999778e-14 -1.61324599744624 9.44362061411831e-07 mirMAP -0.280672215201693 8.08975252886038e-09 NA NA NA hsa-miR-200a-3p IRAK3 4.59434485520731 6.38952518573476e-18 -1.61324599744624 9.44362061411831e-07 mirMAP -0.235202683293506 3.59384388778503e-17 NA NA NA hsa-miR-205-5p IRAK3 4.1389800495524 2.05488295686453e-12 -1.61324599744624 9.44362061411831e-07 mirMAP -0.0755807806905257 0.0044470699147548 NA NA NA hsa-miR-20a-3p IRAK3 2.92621109947706 2.49504904635375e-17 -1.61324599744624 9.44362061411831e-07 mirMAP -0.293239164748252 8.31399787795003e-11 NA NA NA hsa-miR-224-3p IRAK3 1.87536386559317 6.15140969394846e-05 -1.61324599744624 9.44362061411831e-07 mirMAP -0.079493083612545 0.0264165935977338 NA NA NA hsa-miR-25-3p IRAK3 1.36472605225697 4.83790725935681e-11 -1.61324599744624 9.44362061411831e-07 mirMAP -0.486782496706321 8.60201865878405e-11 NA NA NA hsa-miR-29b-2-5p IRAK3 0.910668640983475 0.00666655585493488 -1.61324599744624 9.44362061411831e-07 mirMAP -0.225454736994109 2.14568944357781e-06 NA NA NA hsa-miR-32-5p IRAK3 2.34056473219422 6.24134585974322e-20 -1.61324599744624 9.44362061411831e-07 mirMAP -0.328194671825066 3.51347516406062e-08 NA NA NA hsa-miR-3200-3p IRAK3 2.70510522077868 1.90469509928484e-08 -1.61324599744624 9.44362061411831e-07 mirMAP -0.268417657140478 2.21173595642778e-15 NA NA NA hsa-miR-320a IRAK3 0.438165828017084 0.0390159073347133 -1.61324599744624 9.44362061411831e-07 miRanda -0.177667111226484 0.0204343172413913 NA NA NA hsa-miR-320b IRAK3 1.55692969039548 1.41071034251915e-08 -1.61324599744624 9.44362061411831e-07 miRanda -0.254713964263451 9.45719838918495e-06 NA NA NA hsa-miR-324-5p IRAK3 2.95683728155095 1.32960514360912e-20 -1.61324599744624 9.44362061411831e-07 miRanda -0.351256984620892 8.27603616099315e-14 NA NA NA hsa-miR-326 IRAK3 0.715313016136042 0.0610265683213359 -1.61324599744624 9.44362061411831e-07 miRanda -0.11150566898433 0.00855072371022298 NA NA NA hsa-miR-330-3p IRAK3 0.876747334239085 0.00073709016089703 -1.61324599744624 9.44362061411831e-07 mirMAP -0.227895460995676 0.000226010351889401 NA NA NA hsa-miR-330-5p IRAK3 1.15100069700871 4.85551805046014e-07 -1.61324599744624 9.44362061411831e-07 miRanda -0.259104342543673 0.000204001879358591 NA NA NA hsa-miR-335-3p IRAK3 3.08791651139852 5.31309869723517e-12 -1.61324599744624 9.44362061411831e-07 mirMAP -0.15174104397747 1.29116664173015e-05 NA NA NA hsa-miR-33a-5p IRAK3 3.79671563098419 1.15966309820345e-18 -1.61324599744624 9.44362061411831e-07 mirMAP -0.263603831431637 4.66146319128517e-12 NA NA NA hsa-miR-361-5p IRAK3 0.971859117235239 5.30236555707088e-09 -1.61324599744624 9.44362061411831e-07 miRanda;mirMAP -0.521687719341155 4.54616848788055e-08 NA NA NA hsa-miR-363-3p IRAK3 1.50575300026701 0.00020976164678918 -1.61324599744624 9.44362061411831e-07 mirMAP -0.176370169000037 6.63445963863957e-06 NA NA NA hsa-miR-421 IRAK3 1.17791565395543 6.78526676976629e-06 -1.61324599744624 9.44362061411831e-07 miRanda;mirMAP -0.284717839538607 2.87793406686902e-06 NA NA NA hsa-miR-429 IRAK3 4.48815175680773 2.44117492218206e-17 -1.61324599744624 9.44362061411831e-07 miRanda -0.226880985621525 8.77354448488068e-16 NA NA NA hsa-miR-450b-5p IRAK3 1.69244418548325 1.68064054148881e-10 -1.61324599744624 9.44362061411831e-07 mirMAP -0.268551151836279 5.89719539852997e-06 NA NA NA hsa-miR-501-5p IRAK3 1.93654809410041 1.3779381780759e-10 -1.61324599744624 9.44362061411831e-07 mirMAP -0.296835101027037 2.37939188611957e-08 NA NA NA hsa-miR-505-3p IRAK3 1.45322244209148 8.86597629645867e-10 -1.61324599744624 9.44362061411831e-07 mirMAP -0.253884740154823 0.000142204760654013 NA NA NA hsa-miR-589-3p IRAK3 2.51971841868825 2.39125940264107e-11 -1.61324599744624 9.44362061411831e-07 mirMAP -0.232633878464469 7.63598244506855e-07 NA NA NA hsa-miR-590-3p IRAK3 2.59289455139753 1.03200520972022e-21 -1.61324599744624 9.44362061411831e-07 miRanda;mirMAP -0.260308402381023 6.83807609723304e-06 NA NA NA hsa-miR-590-5p IRAK3 3.18300989862077 2.06813568597893e-26 -1.61324599744624 9.44362061411831e-07 mirMAP -0.329211940694564 1.08651193118683e-10 NA NA NA hsa-miR-660-5p IRAK3 1.82692095272076 1.92040083607196e-13 -1.61324599744624 9.44362061411831e-07 mirMAP -0.313405787681777 5.64080920953627e-07 NA NA NA hsa-miR-7-1-3p IRAK3 1.84950311431067 1.25300363397654e-13 -1.61324599744624 9.44362061411831e-07 mirMAP -0.274128018063691 1.16665950411267e-05 NA NA NA hsa-miR-92a-3p IRAK3 2.06460102658973 1.44784291084757e-19 -1.61324599744624 9.44362061411831e-07 mirMAP -0.516491089062745 4.20857360213128e-15 NA NA NA hsa-miR-944 IRAK3 2.91186649218281 1.31574753528144e-06 -1.61324599744624 9.44362061411831e-07 mirMAP -0.0576020753726856 0.035011913451365 NA NA NA hsa-miR-193a-3p IRAK4 1.60460546928078 2.86169793322984e-07 0.189766326709953 0.138288179984644 miRanda -0.0643946347872097 0.000922054210671554 NA NA NA hsa-miR-421 IRAK4 1.17791565395543 6.78526676976629e-06 0.189766326709953 0.138288179984644 miRanda -0.0654911978686281 0.00524253352144947 NA NA NA hsa-miR-493-5p IRAK4 0.847772103665986 0.00528678068747754 0.189766326709953 0.138288179984644 mirMAP -0.0531323434981004 0.00899858727393343 NA NA NA hsa-miR-106b-5p MAP3K14 2.46782146831112 1.36171495805632e-23 -0.929542138683687 1.31735308419243e-05 MirTarget -0.19000303078406 1.7530926860456e-06 NA NA NA hsa-miR-17-3p MAP3K14 2.2704817679209 1.1667437320211e-22 -0.929542138683687 1.31735308419243e-05 MirTarget -0.103035074073889 0.0162160477134261 NA NA NA hsa-miR-17-5p MAP3K14 3.2710598467455 9.93128340539455e-27 -0.929542138683687 1.31735308419243e-05 MirTarget -0.10840260212945 0.000682220817217628 NA NA NA hsa-miR-185-3p MAP3K14 2.3922478518806 1.3373426768452e-14 -0.929542138683687 1.31735308419243e-05 MirTarget -0.129581834416974 6.081635091056e-05 NA NA NA hsa-miR-20a-5p MAP3K14 3.15577933619191 4.19753346442454e-25 -0.929542138683687 1.31735308419243e-05 MirTarget -0.0880882641958642 0.00623057533379648 NA NA NA hsa-miR-2110 MAP3K14 1.16625590651194 6.4784195289885e-05 -0.929542138683687 1.31735308419243e-05 MirTarget -0.119162411446147 0.00175262129581408 NA NA NA hsa-miR-331-3p MAP3K14 2.28379581858927 1.99663919173155e-18 -0.929542138683687 1.31735308419243e-05 MirTarget -0.177987296479208 2.93504280390057e-06 NA NA NA hsa-miR-345-5p MAP3K14 3.63532310411307 2.2698112107996e-21 -0.929542138683687 1.31735308419243e-05 MirTarget -0.0817123444460956 0.00153484105183177 NA NA NA hsa-miR-34a-5p MAP3K14 1.9016323452565 1.43092834643601e-14 -0.929542138683687 1.31735308419243e-05 MirTarget -0.168509021928338 3.5079349902853e-05 NA NA NA hsa-miR-423-5p MAP3K14 0.963563145758616 9.86109015204915e-07 -0.929542138683687 1.31735308419243e-05 MirTarget -0.153326623515501 0.003656927634938 NA NA NA hsa-miR-429 MAP3K14 4.48815175680773 2.44117492218206e-17 -0.929542138683687 1.31735308419243e-05 miRNATAP -0.149133359352813 2.41419963094442e-16 NA NA NA hsa-miR-874-3p MAP3K14 1.95617235160298 2.0152613104032e-12 -0.929542138683687 1.31735308419243e-05 MirTarget -0.1737967270095 1.57895892349653e-06 NA NA NA hsa-miR-93-5p MAP3K14 3.03961860136032 1.11672209617395e-24 -0.929542138683687 1.31735308419243e-05 MirTarget -0.141287388297998 1.8190573493729e-05 NA NA NA hsa-miR-15a-5p NFKB1 2.34669284378787 1.69544424500258e-23 -0.64818153460532 4.948433163113e-05 miRNAWalker2_validate -0.0801546174320277 0.0108747972008633 NA NA NA hsa-miR-340-5p NFKB1 0.30282999308409 0.157744789519131 -0.64818153460532 4.948433163113e-05 miRNATAP -0.0744624584971565 0.0421797344974554 NA NA NA hsa-miR-429 NFKB1 4.48815175680773 2.44117492218206e-17 -0.64818153460532 4.948433163113e-05 miRanda;miRNATAP -0.084428678890444 9.86979421664935e-10 NA NA NA hsa-miR-450b-5p NFKB1 1.69244418548325 1.68064054148881e-10 -0.64818153460532 4.948433163113e-05 MirTarget;PITA -0.124463449584444 1.35101416784659e-05 NA NA NA hsa-miR-508-3p NFKB1 1.05493034310846 0.0393857095042515 -0.64818153460532 4.948433163113e-05 MirTarget;PITA;miRNATAP -0.0676608246535208 1.06273087417113e-05 NA NA NA hsa-miR-590-3p NFKB1 2.59289455139753 1.03200520972022e-21 -0.64818153460532 4.948433163113e-05 miRanda;mirMAP -0.0662524408941836 0.018526754364778 24200043 We identified important regulators MYC NFKB1 miR-590 and miR-570 and significant miRNA-TF synergistic regulatory motifs by random simulations lung squamous cell cancer hsa-miR-671-5p NFKB1 2.97733652243246 1.21148452344738e-23 -0.64818153460532 4.948433163113e-05 MirTarget -0.0872179046834003 0.00085086206232383 NA NA NA hsa-miR-92a-3p NFKB1 2.06460102658973 1.44784291084757e-19 -0.64818153460532 4.948433163113e-05 miRNAWalker2_validate -0.146602812476967 6.42472618908431e-06 NA NA NA hsa-miR-3065-5p NFKBIA 2.74629919868982 1.86846589298284e-08 -0.720709911772914 0.00030878082790516 MirTarget -0.0530646061776299 0.0269707218151739 NA NA NA hsa-miR-335-5p NFKBIA 1.77247705492746 2.22457658872091e-06 -0.720709911772914 0.00030878082790516 miRNAWalker2_validate -0.0642142341974141 0.012261469137936 NA NA NA hsa-let-7a-5p NGF 0.618599506841644 2.76973453058748e-05 -2.40747957908931 8.29529053936123e-07 MirTarget;TargetScan -0.725600120025055 8.99703032904097e-06 NA NA NA hsa-let-7b-5p NGF 0.604314269683977 0.00140009936153214 -2.40747957908931 8.29529053936123e-07 MirTarget -0.445902124296935 0.000457128474125706 NA NA NA hsa-let-7d-5p NGF 1.33236798905207 1.1741085658466e-13 -2.40747957908931 8.29529053936123e-07 MirTarget -0.678554815907685 1.63174808684775e-07 NA NA NA hsa-let-7e-5p NGF 0.860104282510173 6.04758298373779e-05 -2.40747957908931 8.29529053936123e-07 MirTarget -0.426192872238101 0.000127971345995895 NA NA NA hsa-let-7f-5p NGF 0.495648727272215 0.00355972741198794 -2.40747957908931 8.29529053936123e-07 MirTarget -0.599266844830758 2.3727191387735e-05 NA NA NA hsa-let-7g-5p NGF 1.20061455355116 1.50237505511483e-12 -2.40747957908931 8.29529053936123e-07 MirTarget -1.06245785714021 3.64026543085871e-15 NA NA NA hsa-miR-125a-3p NGF 1.24490295132072 5.26925231010328e-06 -2.40747957908931 8.29529053936123e-07 miRanda -0.250797549188537 0.00395961103629666 NA NA NA hsa-miR-320a NGF 0.438165828017084 0.0390159073347133 -2.40747957908931 8.29529053936123e-07 miRanda -0.444107483987704 8.7035614427142e-05 NA NA NA hsa-miR-320b NGF 1.55692969039548 1.41071034251915e-08 -2.40747957908931 8.29529053936123e-07 miRanda -0.423772071383533 6.50389232533904e-07 NA NA NA hsa-miR-423-5p NGF 0.963563145758616 9.86109015204915e-07 -2.40747957908931 8.29529053936123e-07 MirTarget;miRNATAP -0.803354433746443 1.32594577043773e-11 NA NA NA hsa-miR-429 NGF 4.48815175680773 2.44117492218206e-17 -2.40747957908931 8.29529053936123e-07 miRanda -0.382290239888962 2.67088438561565e-20 NA NA NA hsa-miR-98-5p NGF 1.11154309866014 1.24143909012085e-08 -2.40747957908931 8.29529053936123e-07 MirTarget -0.660953034981452 3.88812196488546e-08 NA NA NA hsa-miR-126-5p PIK3CA 0.895338176458417 2.33372756450713e-05 -0.151828236462886 0.321284398928338 mirMAP -0.103377544898631 0.00298975306098663 NA NA NA hsa-miR-148b-3p PIK3CA 1.97815018171325 6.07715327281595e-26 -0.151828236462886 0.321284398928338 miRNAWalker2_validate -0.0970272057171793 0.00935664640842872 NA NA NA hsa-miR-17-5p PIK3CA 3.2710598467455 9.93128340539455e-27 -0.151828236462886 0.321284398928338 miRNAWalker2_validate -0.0509845431991425 0.0247256477578683 NA NA NA hsa-miR-186-5p PIK3CA 1.47445398888668 3.0781726595413e-15 -0.151828236462886 0.321284398928338 mirMAP -0.101671973753504 0.00842161241015832 NA NA NA hsa-miR-320a PIK3CA 0.438165828017084 0.0390159073347133 -0.151828236462886 0.321284398928338 miRanda -0.153857910084833 9.6763748473785e-06 NA NA NA hsa-miR-335-5p PIK3CA 1.77247705492746 2.22457658872091e-06 -0.151828236462886 0.321284398928338 miRNAWalker2_validate -0.0513085330553527 0.00840603787931949 NA NA NA hsa-miR-3607-3p PIK3CA 2.68532138541128 5.66716351955047e-14 -0.151828236462886 0.321284398928338 mirMAP -0.0603656992151189 0.0033109153473362 NA NA NA hsa-miR-495-3p PIK3CA -0.0847115949846082 0.763475496144456 -0.151828236462886 0.321284398928338 mirMAP -0.0900920798451878 0.000621003495143061 NA NA NA hsa-miR-501-5p PIK3CA 1.93654809410041 1.3779381780759e-10 -0.151828236462886 0.321284398928338 mirMAP -0.0829968054795475 0.000748206365176205 NA NA NA hsa-miR-576-5p PIK3CA 2.20467023993664 3.4053475193793e-19 -0.151828236462886 0.321284398928338 PITA -0.0902220369392094 0.00169985359471657 NA NA NA hsa-miR-582-3p PIK3CA 0.00876844181512659 0.977126166214707 -0.151828236462886 0.321284398928338 miRNATAP -0.0518299165216251 0.0325574956347829 NA NA NA hsa-miR-590-3p PIK3CA 2.59289455139753 1.03200520972022e-21 -0.151828236462886 0.321284398928338 miRanda;mirMAP -0.055368158239037 0.0383091191263138 NA NA NA hsa-miR-590-5p PIK3CA 3.18300989862077 2.06813568597893e-26 -0.151828236462886 0.321284398928338 miRanda -0.0540411360316273 0.0234365949631173 NA NA NA hsa-miR-130a-3p PIK3CB 2.02021855058359 1.26427102520415e-11 0.0812060217229131 0.586462041835271 miRNATAP -0.0548647878304546 0.0199911586887662 NA NA NA hsa-miR-10b-5p PIK3CD -0.155951595811628 0.555006386998027 -0.775351667927902 0.021645534884375 miRNAWalker2_validate -0.175760207889201 0.004748835358114 NA NA NA hsa-miR-1468-5p PIK3CD 0.0469536064343461 0.881810795145912 -0.775351667927902 0.021645534884375 MirTarget -0.223784917601258 1.49208556354691e-05 NA NA NA hsa-miR-29c-3p PIK3CD -0.00968972577705429 0.97099586346872 -0.775351667927902 0.021645534884375 mirMAP -0.250794863940076 4.41169066967662e-05 NA NA NA hsa-miR-30b-3p PIK3CD 0.834142820354026 0.000972582820878813 -0.775351667927902 0.021645534884375 MirTarget -0.531045557079738 2.22640594160628e-17 NA NA NA hsa-miR-30b-5p PIK3CD 0.800822374912712 0.000133601914525413 -0.775351667927902 0.021645534884375 MirTarget -0.411457344396036 9.99002635635066e-08 NA NA NA hsa-miR-30c-5p PIK3CD 0.778774633108 0.000285599212429136 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.461850084291099 7.5210996634642e-10 NA NA NA hsa-miR-30d-5p PIK3CD 0.675423997639582 0.00270618816039773 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.733785480070449 9.30689014359708e-27 NA NA NA hsa-miR-30e-5p PIK3CD 1.23904909539663 1.35561917122157e-09 -0.775351667927902 0.021645534884375 MirTarget -0.597650735147178 7.00788139486401e-15 NA NA NA hsa-miR-320a PIK3CD 0.438165828017084 0.0390159073347133 -0.775351667927902 0.021645534884375 miRanda -0.437629854617933 1.07773535518864e-08 NA NA NA hsa-miR-320b PIK3CD 1.55692969039548 1.41071034251915e-08 -0.775351667927902 0.021645534884375 miRanda -0.282783919094812 1.19379715607107e-06 NA NA NA hsa-miR-324-5p PIK3CD 2.95683728155095 1.32960514360912e-20 -0.775351667927902 0.021645534884375 miRanda -0.265511883710764 4.30342749668002e-08 NA NA NA hsa-miR-3913-5p PIK3CD 2.44353493655328 8.95279496632448e-15 -0.775351667927902 0.021645534884375 mirMAP -0.395313104822511 3.24743386923115e-15 NA NA NA hsa-miR-421 PIK3CD 1.17791565395543 6.78526676976629e-06 -0.775351667927902 0.021645534884375 miRanda -0.235490163150307 0.000146542275873157 NA NA NA hsa-miR-484 PIK3CD 1.81844463411787 1.82951571230938e-15 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.387158078139352 1.61214627982237e-08 NA NA NA hsa-miR-148b-3p PIK3CG 1.97815018171325 6.07715327281595e-26 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.598035215538084 7.05982657783629e-10 NA NA NA hsa-miR-26b-5p PIK3CG 0.885393662798425 3.2116297961629e-06 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.252635166842034 0.0140326902426817 NA NA NA hsa-miR-335-3p PIK3CG 3.08791651139852 5.31309869723517e-12 -1.04493260087656 0.00941484120426313 mirMAP -0.182751911295676 1.44284270796844e-05 NA NA NA hsa-miR-3607-3p PIK3CG 2.68532138541128 5.66716351955047e-14 -1.04493260087656 0.00941484120426313 mirMAP -0.166734433414221 0.00216182223501734 NA NA NA hsa-miR-421 PIK3CG 1.17791565395543 6.78526676976629e-06 -1.04493260087656 0.00941484120426313 miRanda -0.208294811185602 0.00505346682917229 NA NA NA hsa-miR-590-3p PIK3CG 2.59289455139753 1.03200520972022e-21 -1.04493260087656 0.00941484120426313 miRanda -0.160421801003692 0.0232620908281926 NA NA NA hsa-miR-101-5p PIK3R1 0.782067874775122 0.00443725251526842 -1.16357283690918 1.63774086027679e-06 MirTarget -0.115568250605295 0.00948870207662742 NA NA NA hsa-miR-103a-3p PIK3R1 1.44083190496858 1.53799939616416e-13 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.175702483843164 0.00322284399016944 NA NA NA hsa-miR-106a-5p PIK3R1 2.48882002962836 1.99757727374521e-12 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.067882190368009 0.0381305246864511 NA NA NA hsa-miR-106b-5p PIK3R1 2.46782146831112 1.36171495805632e-23 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.24930934707311 3.35624085651532e-08 NA NA NA hsa-miR-107 PIK3R1 1.30977326593435 1.30372468603965e-11 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.201353514049413 0.000854368494298006 NA NA NA hsa-miR-127-5p PIK3R1 1.19850695520181 4.10976607177645e-05 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.164276045731973 4.35688271416755e-05 24004856 Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR 127 in human bladder cancer; These findings provide new insights into the role of miRNAs in the pathway of cancer and give us a hypothesis that miR-127 might play a similar role in regulation and control of PIK3R1 bladder cancer hsa-miR-128-3p PIK3R1 1.63756041666078 6.79626586407187e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.134770050316621 0.0111594593028352 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 2.54959518791507 5.26618591274892e-18 -1.16357283690918 1.63774086027679e-06 MirTarget -0.146009716288673 0.000153002833756534 NA NA NA hsa-miR-132-3p PIK3R1 0.156276992635384 0.408190812100704 -1.16357283690918 1.63774086027679e-06 MirTarget -0.197496588157407 0.00191277589406782 NA NA NA hsa-miR-150-5p PIK3R1 -0.105827294491332 0.799351458244375 -1.16357283690918 1.63774086027679e-06 MirTarget -0.0728800512730481 0.0107125938650315 NA NA NA hsa-miR-15a-5p PIK3R1 2.34669284378787 1.69544424500258e-23 -1.16357283690918 1.63774086027679e-06 MirTarget -0.142181030175195 0.00308171212654804 NA NA NA hsa-miR-15b-5p PIK3R1 1.57112623124278 9.14247846750597e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203388250610072 0.000112366544945594 NA NA NA hsa-miR-16-2-3p PIK3R1 2.31623086727196 4.29838149388188e-20 -1.16357283690918 1.63774086027679e-06 MirTarget -0.207543782293348 3.49270114018875e-06 NA NA NA hsa-miR-16-5p PIK3R1 1.75824877145857 1.68592440033108e-16 -1.16357283690918 1.63774086027679e-06 MirTarget -0.20266090985161 0.000166722510489398 NA NA NA hsa-miR-17-5p PIK3R1 3.2710598467455 9.93128340539455e-27 -1.16357283690918 1.63774086027679e-06 MirTarget;TargetScan;miRNATAP -0.194269031204595 7.03363082546611e-08 NA NA NA hsa-miR-182-5p PIK3R1 3.53923166221814 5.07781258121574e-21 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.0776388342304529 0.00977683704481019 NA NA NA hsa-miR-185-5p PIK3R1 2.34016206907488 1.17481626642022e-26 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.305558512858305 1.29388513669652e-09 NA NA NA hsa-miR-186-5p PIK3R1 1.47445398888668 3.0781726595413e-15 -1.16357283690918 1.63774086027679e-06 mirMAP -0.274872917366815 8.27585129634137e-06 NA NA NA hsa-miR-188-5p PIK3R1 2.52825126596644 6.78099435999778e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.185661747772095 2.50402606338374e-07 NA NA NA hsa-miR-199a-3p PIK3R1 0.640600337515787 0.0380326905134914 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.156998919927599 4.11373421997523e-05 NA NA NA hsa-miR-199a-5p PIK3R1 0.592984035153911 0.0674836634175293 -1.16357283690918 1.63774086027679e-06 miRanda -0.0767286931099107 0.0366580311456345 NA NA NA hsa-miR-199b-3p PIK3R1 0.643923492750702 0.0371742251925406 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.157124307871095 4.00275047495595e-05 NA NA NA hsa-miR-199b-5p PIK3R1 0.218704279044827 0.519493319158441 -1.16357283690918 1.63774086027679e-06 miRanda -0.0803957217297069 0.02198775664261 NA NA NA hsa-miR-200c-3p PIK3R1 3.50132673580082 2.42716349086937e-15 -1.16357283690918 1.63774086027679e-06 mirMAP -0.0549402666456561 0.0342380862176309 NA NA NA hsa-miR-20a-5p PIK3R1 3.15577933619191 4.19753346442454e-25 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.184775072209508 3.70396511881761e-07 NA NA NA hsa-miR-21-5p PIK3R1 2.73773305747971 1.38864982139576e-43 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.344443286817705 1.08270725892964e-10 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.357878936470387 0.232446214501331 -1.16357283690918 1.63774086027679e-06 MirTarget -0.126995222417611 0.00147059810557586 NA NA NA hsa-miR-22-5p PIK3R1 1.88011544159252 1.63978222572222e-16 -1.16357283690918 1.63774086027679e-06 mirMAP -0.292552038138818 3.89552165607854e-09 NA NA NA hsa-miR-221-3p PIK3R1 0.451556679024397 0.0909808299917811 -1.16357283690918 1.63774086027679e-06 MirTarget -0.108240747635063 0.015387314456947 NA NA NA hsa-miR-222-3p PIK3R1 0.851783756239071 0.00266783568486918 -1.16357283690918 1.63774086027679e-06 MirTarget -0.122260306324505 0.00346350093932025 NA NA NA hsa-miR-29a-3p PIK3R1 -0.35074463683376 0.161238718982428 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.197768036084372 3.04095884680599e-05 NA NA NA hsa-miR-29b-3p PIK3R1 1.65828197923813 1.02676780888141e-09 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.226570180742736 9.59427672061032e-08 NA NA NA hsa-miR-3065-5p PIK3R1 2.74629919868982 1.86846589298284e-08 -1.16357283690918 1.63774086027679e-06 MirTarget;mirMAP;miRNATAP -0.121456370441073 3.04699134862982e-05 NA NA NA hsa-miR-32-3p PIK3R1 2.02436999565685 5.94091197945307e-09 -1.16357283690918 1.63774086027679e-06 mirMAP -0.0809069992032009 0.0349095308992423 NA NA NA hsa-miR-320b PIK3R1 1.55692969039548 1.41071034251915e-08 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.0967011095672297 0.0236391980598286 NA NA NA hsa-miR-335-3p PIK3R1 3.08791651139852 5.31309869723517e-12 -1.16357283690918 1.63774086027679e-06 mirMAP -0.076442193839567 0.00303273833312375 NA NA NA hsa-miR-3607-3p PIK3R1 2.68532138541128 5.66716351955047e-14 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.0715397351064048 0.0310087142370623 NA NA NA hsa-miR-369-3p PIK3R1 0.946781510019564 0.00134850306966842 -1.16357283690918 1.63774086027679e-06 PITA -0.165045838001649 3.68847028364345e-05 NA NA NA hsa-miR-409-3p PIK3R1 0.877551657794358 0.00171210686733898 -1.16357283690918 1.63774086027679e-06 mirMAP -0.105859697586648 0.0126015776971144 NA NA NA hsa-miR-424-5p PIK3R1 1.61930224569578 1.89642549274994e-10 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203727044936863 7.79524954848401e-06 NA NA NA hsa-miR-429 PIK3R1 4.48815175680773 2.44117492218206e-17 -1.16357283690918 1.63774086027679e-06 mirMAP;miRNATAP -0.0554753866913029 0.00987336466542612 NA NA NA hsa-miR-450b-5p PIK3R1 1.69244418548325 1.68064054148881e-10 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.119371689321084 0.0066882062526509 NA NA NA hsa-miR-455-3p PIK3R1 3.06093594997644 3.54590649799868e-16 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.151223028806072 5.34851043578223e-07 NA NA NA hsa-miR-485-3p PIK3R1 0.442820096243914 0.166634696770945 -1.16357283690918 1.63774086027679e-06 mirMAP -0.104228852223792 0.00542492277409986 NA NA NA hsa-miR-493-5p PIK3R1 0.847772103665986 0.00528678068747754 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.141629319654 0.000286613564823519 NA NA NA hsa-miR-495-3p PIK3R1 -0.0847115949846082 0.763475496144456 -1.16357283690918 1.63774086027679e-06 mirMAP -0.0960899695814073 0.0239315868381009 NA NA NA hsa-miR-508-3p PIK3R1 1.05493034310846 0.0393857095042515 -1.16357283690918 1.63774086027679e-06 PITA -0.0523898891576641 0.0269689884288959 NA NA NA hsa-miR-532-3p PIK3R1 1.96631878320218 4.53421954361695e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.183574493282594 1.45132602336302e-05 NA NA NA hsa-miR-584-5p PIK3R1 2.7326672683732 9.92677936962233e-12 -1.16357283690918 1.63774086027679e-06 mirMAP -0.136506526285572 1.76178566940588e-06 NA NA NA hsa-miR-589-3p PIK3R1 2.51971841868825 2.39125940264107e-11 -1.16357283690918 1.63774086027679e-06 mirMAP -0.146863008859422 2.43953052082368e-05 NA NA NA hsa-miR-590-3p PIK3R1 2.59289455139753 1.03200520972022e-21 -1.16357283690918 1.63774086027679e-06 miRanda;mirMAP -0.251414695908109 2.6774008322444e-09 NA NA NA hsa-miR-590-5p PIK3R1 3.18300989862077 2.06813568597893e-26 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.233958943001206 5.13569363038349e-10 NA NA NA hsa-miR-629-3p PIK3R1 2.36570947321815 1.33458201201618e-11 -1.16357283690918 1.63774086027679e-06 MirTarget -0.157530213698435 2.37486100403133e-05 NA NA NA hsa-miR-93-5p PIK3R1 3.03961860136032 1.11672209617395e-24 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.155676924698248 3.5347453293642e-05 NA NA NA hsa-miR-96-5p PIK3R1 4.89433085814374 1.92000659886961e-31 -1.16357283690918 1.63774086027679e-06 TargetScan;miRNATAP -0.102966561567807 0.000122371084822612 NA NA NA hsa-miR-133a-3p PIK3R2 -3.38501431117712 1.32336729742128e-13 0.516358399200751 7.40068114798748e-05 miRNAWalker2_validate -0.0531718506280371 6.66834984264845e-05 NA NA NA hsa-miR-1271-5p PIK3R3 0.970418832993172 0.000609742584380688 -0.627704444396048 0.00578594022892978 mirMAP -0.151257171385516 9.56593049733625e-05 NA NA NA hsa-miR-181a-5p PIK3R3 2.29556023480783 1.8138457900616e-21 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.108906602043709 0.0127134423930606 NA NA NA hsa-miR-181b-5p PIK3R3 2.49307679431293 3.92829250217627e-20 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.0888610194282689 0.0225315211910636 NA NA NA hsa-miR-18a-3p PIK3R3 2.14813400940323 2.23460809936028e-06 -0.627704444396048 0.00578594022892978 miRNAWalker2_validate -0.10342220794232 0.000634896497880219 NA NA NA hsa-miR-19a-3p PIK3R3 3.42309334186656 3.02671914353412e-28 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.120784849374387 0.0002630092907536 NA NA NA hsa-miR-19b-3p PIK3R3 2.49529833021187 1.57028265846699e-23 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.146052627292238 0.000482454548266062 NA NA NA hsa-miR-222-5p PIK3R3 1.25632771414778 0.000138653440511922 -0.627704444396048 0.00578594022892978 mirMAP -0.146201383530692 9.47483044017924e-06 NA NA NA hsa-miR-26b-5p PIK3R3 0.885393662798425 3.2116297961629e-06 -0.627704444396048 0.00578594022892978 miRNATAP -0.184498425433638 0.00145436639404193 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.55384379072167 4.76870585070176e-05 -0.627704444396048 0.00578594022892978 mirMAP -0.182944374912975 8.7655907053222e-10 NA NA NA hsa-miR-3065-5p PIK3R3 2.74629919868982 1.86846589298284e-08 -0.627704444396048 0.00578594022892978 mirMAP;miRNATAP -0.0640162238588998 0.0187365945874149 NA NA NA hsa-miR-365a-3p PIK3R3 -0.0388985816963467 0.859114494267351 -0.627704444396048 0.00578594022892978 MirTarget -0.222976439335601 9.85809729911043e-06 NA NA NA hsa-miR-511-5p PIK3R3 1.04499312543772 0.00234126154508174 -0.627704444396048 0.00578594022892978 MirTarget -0.132527709680848 3.18921565069019e-05 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-590-5p PIK3R3 3.18300989862077 2.06813568597893e-26 -0.627704444396048 0.00578594022892978 miRanda -0.0814160343557343 0.022364395955343 NA NA NA hsa-miR-708-3p PIK3R3 2.80907765282502 3.07460722669281e-14 -0.627704444396048 0.00578594022892978 mirMAP -0.0877076522501003 0.00235951475615563 NA NA NA hsa-miR-92a-3p PIK3R3 2.06460102658973 1.44784291084757e-19 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.185970971603602 5.73870254874264e-05 NA NA NA hsa-miR-107 PIK3R5 1.30977326593435 1.30372468603965e-11 -0.990769658200862 0.00792713202187119 miRanda -0.533513362792699 4.18278914923372e-09 NA NA NA hsa-miR-125a-3p PIK3R5 1.24490295132072 5.26925231010328e-06 -0.990769658200862 0.00792713202187119 miRanda -0.135508023882326 0.0399369211652034 NA NA NA hsa-miR-125a-5p PIK3R5 0.599529391575274 0.0102300147180307 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.398754902125041 2.22481895610409e-07 NA NA NA hsa-miR-182-5p PIK3R5 3.53923166221814 5.07781258121574e-21 -0.990769658200862 0.00792713202187119 MirTarget -0.391730270801049 4.50362857100536e-19 NA NA NA hsa-miR-185-5p PIK3R5 2.34016206907488 1.17481626642022e-26 -0.990769658200862 0.00792713202187119 MirTarget -0.277336834855249 0.000367374066791577 NA NA NA hsa-miR-18a-3p PIK3R5 2.14813400940323 2.23460809936028e-06 -0.990769658200862 0.00792713202187119 MirTarget -0.132688083528877 0.0077571943603639 NA NA NA hsa-miR-330-5p PIK3R5 1.15100069700871 4.85551805046014e-07 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.220865262481851 0.00496435762424894 NA NA NA hsa-miR-944 PIK3R5 2.91186649218281 1.31574753528144e-06 -0.990769658200862 0.00792713202187119 mirMAP -0.201291119960673 1.82909637448261e-11 NA NA NA hsa-let-7f-5p PPP3CA 0.495648727272215 0.00355972741198794 -0.281979431665802 0.0843014975757299 miRNATAP -0.145174821876866 0.00196996187493329 NA NA NA hsa-let-7g-5p PPP3CA 1.20061455355116 1.50237505511483e-12 -0.281979431665802 0.0843014975757299 miRNATAP -0.256650979931267 1.4045207283454e-08 NA NA NA hsa-miR-106a-5p PPP3CA 2.48882002962836 1.99757727374521e-12 -0.281979431665802 0.0843014975757299 miRNATAP -0.11191172835948 1.79556273427309e-07 NA NA NA hsa-miR-106b-5p PPP3CA 2.46782146831112 1.36171495805632e-23 -0.281979431665802 0.0843014975757299 miRNATAP -0.184105953911301 6.84398280050895e-10 NA NA NA hsa-miR-17-3p PPP3CA 2.2704817679209 1.1667437320211e-22 -0.281979431665802 0.0843014975757299 MirTarget -0.131133816129638 4.79999765543855e-05 NA NA NA hsa-miR-17-5p PPP3CA 3.2710598467455 9.93128340539455e-27 -0.281979431665802 0.0843014975757299 miRNATAP -0.0933241886409001 0.000109538547214252 NA NA NA hsa-miR-186-5p PPP3CA 1.47445398888668 3.0781726595413e-15 -0.281979431665802 0.0843014975757299 mirMAP -0.185694598107894 5.66511837519636e-06 NA NA NA hsa-miR-194-5p PPP3CA 1.8992998339217 3.76507853301977e-10 -0.281979431665802 0.0843014975757299 MirTarget -0.17070662815415 7.35898582017249e-12 NA NA NA hsa-miR-20a-5p PPP3CA 3.15577933619191 4.19753346442454e-25 -0.281979431665802 0.0843014975757299 miRNATAP -0.109419648077418 6.17460161232474e-06 NA NA NA hsa-miR-20b-5p PPP3CA 2.07706563022469 1.10107236083433e-05 -0.281979431665802 0.0843014975757299 miRNATAP -0.113387749946454 1.85473104688059e-12 NA NA NA hsa-miR-3065-3p PPP3CA 2.16221780121195 9.65525739884541e-09 -0.281979431665802 0.0843014975757299 miRNATAP -0.0625562456316198 0.00230586582946532 NA NA NA hsa-miR-3065-5p PPP3CA 2.74629919868982 1.86846589298284e-08 -0.281979431665802 0.0843014975757299 mirMAP;miRNATAP -0.0509505793517531 0.00882650698743328 NA NA NA hsa-miR-30c-5p PPP3CA 0.778774633108 0.000285599212429136 -0.281979431665802 0.0843014975757299 miRNATAP -0.212081199369466 4.85681407465908e-09 NA NA NA hsa-miR-30d-5p PPP3CA 0.675423997639582 0.00270618816039773 -0.281979431665802 0.0843014975757299 miRNATAP -0.142883121139453 4.34068465949306e-05 NA NA NA hsa-miR-320a PPP3CA 0.438165828017084 0.0390159073347133 -0.281979431665802 0.0843014975757299 miRanda -0.0836438650578148 0.0256799522502136 NA NA NA hsa-miR-320b PPP3CA 1.55692969039548 1.41071034251915e-08 -0.281979431665802 0.0843014975757299 miRanda -0.0747517149496106 0.00834116436794549 NA NA NA hsa-miR-335-3p PPP3CA 3.08791651139852 5.31309869723517e-12 -0.281979431665802 0.0843014975757299 MirTarget -0.0578428183849171 0.000713654659827143 NA NA NA hsa-miR-33a-3p PPP3CA 1.72765312072219 1.51784443453521e-07 -0.281979431665802 0.0843014975757299 MirTarget;mirMAP;miRNATAP -0.0920673109692904 0.000382894111423911 NA NA NA hsa-miR-3607-3p PPP3CA 2.68532138541128 5.66716351955047e-14 -0.281979431665802 0.0843014975757299 MirTarget;mirMAP;miRNATAP -0.0675434123943502 0.00209514647933572 NA NA NA hsa-miR-361-5p PPP3CA 0.971859117235239 5.30236555707088e-09 -0.281979431665802 0.0843014975757299 miRanda -0.0937552829513574 0.0478432981986854 NA NA NA hsa-miR-3653-3p PPP3CA 1.85886928622326 2.98407490336841e-08 -0.281979431665802 0.0843014975757299 MirTarget -0.0655527569596621 0.00749580252049549 NA NA NA hsa-miR-374b-3p PPP3CA 0.930487774873495 2.74420094310516e-05 -0.281979431665802 0.0843014975757299 MirTarget -0.09424081105526 0.00818093510006297 NA NA NA hsa-miR-501-3p PPP3CA 1.83132758513743 1.10971547702065e-10 -0.281979431665802 0.0843014975757299 MirTarget;PITA;miRNATAP -0.114452652427796 2.34298968304304e-05 NA NA NA hsa-miR-502-3p PPP3CA 1.50560877085049 1.2647489756373e-11 -0.281979431665802 0.0843014975757299 MirTarget;PITA;miRNATAP -0.15529134445823 7.08901270771209e-06 NA NA NA hsa-miR-590-3p PPP3CA 2.59289455139753 1.03200520972022e-21 -0.281979431665802 0.0843014975757299 miRanda;mirMAP -0.0703201763483185 0.0137359066554011 NA NA NA hsa-miR-590-5p PPP3CA 3.18300989862077 2.06813568597893e-26 -0.281979431665802 0.0843014975757299 PITA;miRanda;miRNATAP -0.0925111885367781 0.000265103601175037 NA NA NA hsa-miR-664a-3p PPP3CA 0.634721925861133 0.00520070178640421 -0.281979431665802 0.0843014975757299 mirMAP -0.150747155909677 1.3336356409105e-05 NA NA NA hsa-miR-7-1-3p PPP3CA 1.84950311431067 1.25300363397654e-13 -0.281979431665802 0.0843014975757299 MirTarget;mirMAP -0.119727173710851 9.40140707131449e-05 NA NA NA hsa-miR-93-3p PPP3CA 2.85383869771942 5.64481766902125e-23 -0.281979431665802 0.0843014975757299 miRNATAP -0.152353546507485 2.15079066361371e-09 NA NA NA hsa-miR-93-5p PPP3CA 3.03961860136032 1.11672209617395e-24 -0.281979431665802 0.0843014975757299 miRNATAP -0.156066415468858 2.44288871078656e-10 NA NA NA hsa-miR-96-5p PPP3CA 4.89433085814374 1.92000659886961e-31 -0.281979431665802 0.0843014975757299 TargetScan -0.0953029651395409 6.61378921407754e-08 NA NA NA hsa-miR-107 PPP3CB 1.30977326593435 1.30372468603965e-11 -1.03671584843429 6.12489584217064e-15 miRanda -0.224024061633064 1.13198598297881e-11 NA NA NA hsa-miR-10b-5p PPP3CB -0.155951595811628 0.555006386998027 -1.03671584843429 6.12489584217064e-15 miRNAWalker2_validate -0.0869895000990222 0.000541944702005189 NA NA NA hsa-miR-140-5p PPP3CB 0.844753502512594 3.73722278438606e-05 -1.03671584843429 6.12489584217064e-15 miRanda -0.0652127605287475 0.0444357882558287 NA NA NA hsa-miR-15a-5p PPP3CB 2.34669284378787 1.69544424500258e-23 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.188034579267018 6.2219880807044e-13 NA NA NA hsa-miR-15b-5p PPP3CB 1.57112623124278 9.14247846750597e-13 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.245380830384666 5.15260568991425e-18 NA NA NA hsa-miR-16-5p PPP3CB 1.75824877145857 1.68592440033108e-16 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.219222038672189 7.36535140884335e-14 NA NA NA hsa-miR-20a-3p PPP3CB 2.92621109947706 2.49504904635375e-17 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.113868623377048 9.37084199962394e-10 NA NA NA hsa-miR-26b-5p PPP3CB 0.885393662798425 3.2116297961629e-06 -1.03671584843429 6.12489584217064e-15 MirTarget;miRNATAP -0.129362759155204 0.000196474595826764 NA NA NA hsa-miR-3065-5p PPP3CB 2.74629919868982 1.86846589298284e-08 -1.03671584843429 6.12489584217064e-15 mirMAP -0.0620114432668879 0.000138854612360636 NA NA NA hsa-miR-30c-5p PPP3CB 0.778774633108 0.000285599212429136 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.165551300673001 5.92944884537219e-08 NA NA NA hsa-miR-30d-5p PPP3CB 0.675423997639582 0.00270618816039773 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.128345099197797 1.20380214861929e-05 NA NA NA hsa-miR-320a PPP3CB 0.438165828017084 0.0390159073347133 -1.03671584843429 6.12489584217064e-15 miRanda -0.133683103961461 1.89473747516991e-05 NA NA NA hsa-miR-320b PPP3CB 1.55692969039548 1.41071034251915e-08 -1.03671584843429 6.12489584217064e-15 miRanda -0.157984627594008 1.12882018634839e-11 NA NA NA hsa-miR-326 PPP3CB 0.715313016136042 0.0610265683213359 -1.03671584843429 6.12489584217064e-15 MirTarget;PITA;miRanda -0.0835817880449422 1.27907495308049e-06 NA NA NA hsa-miR-330-5p PPP3CB 1.15100069700871 4.85551805046014e-07 -1.03671584843429 6.12489584217064e-15 MirTarget;PITA;miRanda -0.122279132326624 1.90117350044819e-05 NA NA NA hsa-miR-339-5p PPP3CB 2.68710938429893 3.03134080808154e-16 -1.03671584843429 6.12489584217064e-15 miRanda -0.129274316344838 1.00359131009696e-11 NA NA NA hsa-miR-342-3p PPP3CB 1.49115144672245 1.43879249744621e-07 -1.03671584843429 6.12489584217064e-15 miRanda -0.0568247087163028 0.0139729208657623 NA NA NA hsa-miR-34c-3p PPP3CB 2.41359195938096 3.46966584087088e-10 -1.03671584843429 6.12489584217064e-15 MirTarget -0.0659089832974402 0.000154038201668703 NA NA NA hsa-miR-361-5p PPP3CB 0.971859117235239 5.30236555707088e-09 -1.03671584843429 6.12489584217064e-15 miRanda -0.319599472524393 7.32960352437588e-17 NA NA NA hsa-miR-421 PPP3CB 1.17791565395543 6.78526676976629e-06 -1.03671584843429 6.12489584217064e-15 miRanda -0.107753543524587 1.70411972807069e-05 NA NA NA hsa-miR-424-5p PPP3CB 1.61930224569578 1.89642549274994e-10 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.0982586568405929 0.000116297130158393 NA NA NA hsa-miR-429 PPP3CB 4.48815175680773 2.44117492218206e-17 -1.03671584843429 6.12489584217064e-15 miRanda -0.104170748345545 1.10824048087982e-19 NA NA NA hsa-miR-450b-5p PPP3CB 1.69244418548325 1.68064054148881e-10 -1.03671584843429 6.12489584217064e-15 MirTarget;PITA;miRNATAP -0.0950280485274194 0.000101055470981506 NA NA NA hsa-miR-497-5p PPP3CB 0.0257087130056286 0.918145413833358 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.0865810330364637 0.00114071612935126 NA NA NA hsa-miR-501-5p PPP3CB 1.93654809410041 1.3779381780759e-10 -1.03671584843429 6.12489584217064e-15 PITA;miRNATAP -0.110941325807012 4.19796167603695e-07 NA NA NA hsa-miR-590-3p PPP3CB 2.59289455139753 1.03200520972022e-21 -1.03671584843429 6.12489584217064e-15 miRanda -0.160737546369274 6.57567642585996e-12 NA NA NA hsa-miR-7-1-3p PPP3CB 1.84950311431067 1.25300363397654e-13 -1.03671584843429 6.12489584217064e-15 mirMAP -0.170702158890249 1.5272735318301e-11 NA NA NA hsa-miR-361-5p PPP3CC 0.971859117235239 5.30236555707088e-09 -0.895441456978914 1.07671854464434e-07 miRanda -0.275565592476708 1.65394541713718e-08 NA NA NA hsa-miR-375 PPP3CC 1.13910305294079 0.0512283522214186 -0.895441456978914 1.07671854464434e-07 miRanda -0.0513795275892868 0.000252166740284317 NA NA NA hsa-miR-500a-3p PPP3CC 1.47161373123699 5.30571342631915e-09 -0.895441456978914 1.07671854464434e-07 MirTarget;miRNATAP -0.11299814981742 0.000453955248711429 NA NA NA hsa-miR-501-3p PPP3CC 1.83132758513743 1.10971547702065e-10 -0.895441456978914 1.07671854464434e-07 MirTarget;PITA;miRNATAP -0.0952633026086104 0.00081490311004322 NA NA NA hsa-miR-502-3p PPP3CC 1.50560877085049 1.2647489756373e-11 -0.895441456978914 1.07671854464434e-07 MirTarget;PITA;miRNATAP -0.137316418088144 0.000157963764790067 NA NA NA hsa-miR-101-3p PPP3R1 0.522819989585461 0.00375627731618038 -0.0284423401171923 0.760566460331176 miRNATAP -0.130896280595902 1.18496266678438e-07 NA NA NA hsa-miR-181c-5p PPP3R1 1.58587920618301 1.57506918816933e-10 -0.0284423401171923 0.760566460331176 MirTarget;miRNATAP -0.0769473663852459 1.2130935030742e-05 NA NA NA hsa-miR-30b-5p PPP3R1 0.800822374912712 0.000133601914525413 -0.0284423401171923 0.760566460331176 MirTarget -0.0615153401490221 0.00393582602697426 NA NA NA hsa-miR-30c-5p PPP3R1 0.778774633108 0.000285599212429136 -0.0284423401171923 0.760566460331176 MirTarget;miRNATAP -0.0910480965301957 1.09868049452331e-05 NA NA NA hsa-miR-30d-5p PPP3R1 0.675423997639582 0.00270618816039773 -0.0284423401171923 0.760566460331176 MirTarget;miRNATAP -0.0563515897046211 0.00462239757740787 NA NA NA hsa-miR-30e-5p PPP3R1 1.23904909539663 1.35561917122157e-09 -0.0284423401171923 0.760566460331176 MirTarget -0.0867370933489975 5.51029022440179e-05 NA NA NA hsa-miR-320a PPP3R1 0.438165828017084 0.0390159073347133 -0.0284423401171923 0.760566460331176 PITA;miRanda -0.0737824308135289 0.000484362233028493 NA NA NA hsa-miR-34a-5p PPP3R1 1.9016323452565 1.43092834643601e-14 -0.0284423401171923 0.760566460331176 miRNAWalker2_validate -0.0739854877233908 2.26982964925871e-05 NA NA NA hsa-miR-590-3p PRKACA 2.59289455139753 1.03200520972022e-21 -0.0623357146206391 0.530117963925869 miRanda -0.0531211945850324 0.00199296030113284 NA NA NA hsa-miR-625-5p PRKACA 1.42540152147292 1.95797147911206e-06 -0.0623357146206391 0.530117963925869 MirTarget -0.0575476083738286 0.000848124844285933 NA NA NA hsa-let-7a-3p PRKACB 1.42015538786275 7.03375209382654e-13 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP;miRNATAP -0.21962130459547 5.79651670137419e-05 NA NA NA hsa-let-7b-3p PRKACB 0.868207752019623 1.30460056774366e-05 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP;miRNATAP -0.185130585565506 0.000844018426388941 NA NA NA hsa-let-7d-3p PRKACB 0.837345596411224 1.39469480391458e-05 -1.11910356116881 7.24897707751757e-07 MirTarget -0.193122206370836 0.000761987397647901 NA NA NA hsa-let-7f-1-3p PRKACB 1.55054488387679 7.31326775537952e-11 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP -0.13342047017702 0.00451064067873152 NA NA NA hsa-miR-126-5p PRKACB 0.895338176458417 2.33372756450713e-05 -1.11910356116881 7.24897707751757e-07 mirMAP -0.171245788041164 0.00102349617124601 NA NA NA hsa-miR-141-3p PRKACB 5.02396127982626 2.19224509139725e-24 -1.11910356116881 7.24897707751757e-07 MirTarget;TargetScan;miRNATAP -0.131248917259806 2.40182503281301e-10 NA NA NA hsa-miR-16-2-3p PRKACB 2.31623086727196 4.29838149388188e-20 -1.11910356116881 7.24897707751757e-07 mirMAP -0.211513116774948 3.56654687944943e-07 NA NA NA hsa-miR-17-5p PRKACB 3.2710598467455 9.93128340539455e-27 -1.11910356116881 7.24897707751757e-07 TargetScan -0.195594044734934 5.04690942157379e-09 NA NA NA hsa-miR-182-5p PRKACB 3.53923166221814 5.07781258121574e-21 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.141282769334308 3.27226662914892e-07 NA NA NA hsa-miR-183-5p PRKACB 4.19757025992371 4.79612296318304e-26 -1.11910356116881 7.24897707751757e-07 MirTarget -0.132170429294976 3.08274590025093e-07 NA NA NA hsa-miR-18a-5p PRKACB 3.78535678765353 3.72446596213886e-26 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.170312158994311 1.8268780409686e-08 NA NA NA hsa-miR-193a-3p PRKACB 1.60460546928078 2.86169793322984e-07 -1.11910356116881 7.24897707751757e-07 miRanda -0.185097829574766 8.14913568795542e-08 NA NA NA hsa-miR-19a-3p PRKACB 3.42309334186656 3.02671914353412e-28 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.217127685863828 2.72225260525319e-11 NA NA NA hsa-miR-19b-3p PRKACB 2.49529833021187 1.57028265846699e-23 -1.11910356116881 7.24897707751757e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.267352556269149 9.00420806048956e-11 NA NA NA hsa-miR-200a-3p PRKACB 4.59434485520731 6.38952518573476e-18 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.0898539859960936 5.20182026041999e-06 NA NA NA hsa-miR-200b-3p PRKACB 3.78235093249346 3.18343003239465e-14 -1.11910356116881 7.24897707751757e-07 MirTarget;TargetScan -0.079282880201862 0.000208224082323168 NA NA NA hsa-miR-200c-3p PRKACB 3.50132673580082 2.42716349086937e-15 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.125201076382777 1.50017445380767e-07 NA NA NA hsa-miR-2110 PRKACB 1.16625590651194 6.4784195289885e-05 -1.11910356116881 7.24897707751757e-07 MirTarget -0.106141262528439 0.00882154187258127 NA NA NA hsa-miR-3065-5p PRKACB 2.74629919868982 1.86846589298284e-08 -1.11910356116881 7.24897707751757e-07 MirTarget -0.103807774563958 0.000132862723321062 NA NA NA hsa-miR-30d-3p PRKACB 0.977747550180601 4.3048212205381e-05 -1.11910356116881 7.24897707751757e-07 mirMAP -0.230639716646997 4.57613056559806e-07 NA NA NA hsa-miR-32-3p PRKACB 2.02436999565685 5.94091197945307e-09 -1.11910356116881 7.24897707751757e-07 mirMAP;miRNATAP -0.100714992594509 0.00471640544853458 NA NA NA hsa-miR-330-3p PRKACB 0.876747334239085 0.00073709016089703 -1.11910356116881 7.24897707751757e-07 MirTarget -0.0839496029016369 0.0489634749130281 NA NA NA hsa-miR-339-5p PRKACB 2.68710938429893 3.03134080808154e-16 -1.11910356116881 7.24897707751757e-07 miRanda -0.145165623596419 6.50854523117634e-06 NA NA NA hsa-miR-34a-5p PRKACB 1.9016323452565 1.43092834643601e-14 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.238915288481547 2.59419071561778e-08 NA NA NA hsa-miR-361-5p PRKACB 0.971859117235239 5.30236555707088e-09 -1.11910356116881 7.24897707751757e-07 miRanda -0.178114095699739 0.00724869450353386 NA NA NA hsa-miR-362-3p PRKACB 2.0756816987665 3.89026064579331e-12 -1.11910356116881 7.24897707751757e-07 PITA;miRanda;miRNATAP -0.2320492729467 2.29661541166603e-10 NA NA NA hsa-miR-362-5p PRKACB 1.59303749908759 9.582675908797e-08 -1.11910356116881 7.24897707751757e-07 PITA -0.194987590184185 6.59081906609811e-08 NA NA NA hsa-miR-3653-3p PRKACB 1.85886928622326 2.98407490336841e-08 -1.11910356116881 7.24897707751757e-07 MirTarget -0.105612181380441 0.00210192398606289 NA NA NA hsa-miR-374a-5p PRKACB 0.484615721953736 0.0042981729815149 -1.11910356116881 7.24897707751757e-07 mirMAP -0.166638670031419 0.0116689154239509 NA NA NA hsa-miR-429 PRKACB 4.48815175680773 2.44117492218206e-17 -1.11910356116881 7.24897707751757e-07 MirTarget;PITA;miRanda;miRNATAP -0.0781107785224374 8.79409529061615e-05 NA NA NA hsa-miR-450b-5p PRKACB 1.69244418548325 1.68064054148881e-10 -1.11910356116881 7.24897707751757e-07 mirMAP -0.0841826254341061 0.0403611944801111 NA NA NA hsa-miR-532-5p PRKACB 1.55697650978597 1.57884735535196e-11 -1.11910356116881 7.24897707751757e-07 PITA -0.27784223940084 1.83614058183971e-09 NA NA NA hsa-miR-590-3p PRKACB 2.59289455139753 1.03200520972022e-21 -1.11910356116881 7.24897707751757e-07 MirTarget;PITA;miRanda;miRNATAP -0.20137371596257 3.58630956215221e-07 NA NA NA hsa-miR-590-5p PRKACB 3.18300989862077 2.06813568597893e-26 -1.11910356116881 7.24897707751757e-07 miRanda -0.22361088291547 1.69108646897883e-10 NA NA NA hsa-miR-7-1-3p PRKACB 1.84950311431067 1.25300363397654e-13 -1.11910356116881 7.24897707751757e-07 mirMAP -0.160819398581311 0.000186176032630634 NA NA NA hsa-miR-708-3p PRKACB 2.80907765282502 3.07460722669281e-14 -1.11910356116881 7.24897707751757e-07 mirMAP -0.107628106192083 0.000190951072862047 NA NA NA hsa-miR-93-5p PRKACB 3.03961860136032 1.11672209617395e-24 -1.11910356116881 7.24897707751757e-07 miRNAWalker2_validate -0.194608106414379 2.15593790853491e-08 NA NA NA hsa-miR-96-5p PRKACB 4.89433085814374 1.92000659886961e-31 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.144257226112366 5.04306410867738e-09 NA NA NA hsa-miR-107 PRKAR1A 1.30977326593435 1.30372468603965e-11 -0.494707246064478 1.09832496534671e-05 miRanda -0.0662503424746762 0.0174384967046709 NA NA NA hsa-miR-1296-5p PRKAR1A 1.20556568733873 8.93601534401924e-06 -0.494707246064478 1.09832496534671e-05 miRNAWalker2_validate -0.0828840059385087 3.06637773247924e-05 NA NA NA hsa-miR-141-3p PRKAR1A 5.02396127982626 2.19224509139725e-24 -0.494707246064478 1.09832496534671e-05 TargetScan -0.050291674226767 1.14324675537054e-06 NA NA NA hsa-miR-16-2-3p PRKAR1A 2.31623086727196 4.29838149388188e-20 -0.494707246064478 1.09832496534671e-05 mirMAP -0.0918148205391201 8.29785718068452e-06 NA NA NA hsa-miR-16-5p PRKAR1A 1.75824877145857 1.68592440033108e-16 -0.494707246064478 1.09832496534671e-05 miRNAWalker2_validate -0.0635766416738103 0.0105940278364239 NA NA NA hsa-miR-182-5p PRKAR1A 3.53923166221814 5.07781258121574e-21 -0.494707246064478 1.09832496534671e-05 miRNATAP -0.0567111816542074 3.66485110433976e-05 NA NA NA hsa-miR-186-5p PRKAR1A 1.47445398888668 3.0781726595413e-15 -0.494707246064478 1.09832496534671e-05 mirMAP -0.158555937704806 1.81385800124173e-08 NA NA NA hsa-miR-192-5p PRKAR1A 2.69002528723195 1.22990188194432e-16 -0.494707246064478 1.09832496534671e-05 miRNAWalker2_validate -0.0727399521419155 6.08880831882451e-06 NA NA NA hsa-miR-25-3p PRKAR1A 1.36472605225697 4.83790725935681e-11 -0.494707246064478 1.09832496534671e-05 miRNAWalker2_validate -0.130633923717046 3.57662021897474e-07 NA NA NA hsa-miR-30b-5p PRKAR1A 0.800822374912712 0.000133601914525413 -0.494707246064478 1.09832496534671e-05 mirMAP -0.109738357042516 2.35678449980593e-05 NA NA NA hsa-miR-30c-5p PRKAR1A 0.778774633108 0.000285599212429136 -0.494707246064478 1.09832496534671e-05 mirMAP -0.117852671733036 3.18561702613009e-06 NA NA NA hsa-miR-30e-5p PRKAR1A 1.23904909539663 1.35561917122157e-09 -0.494707246064478 1.09832496534671e-05 mirMAP -0.13563514438677 2.13471830667205e-07 NA NA NA hsa-miR-32-3p PRKAR1A 2.02436999565685 5.94091197945307e-09 -0.494707246064478 1.09832496534671e-05 mirMAP -0.0642208683396288 0.000253119593681182 NA NA NA hsa-miR-320b PRKAR1A 1.55692969039548 1.41071034251915e-08 -0.494707246064478 1.09832496534671e-05 miRanda -0.0507406473741568 0.00977763068457851 NA NA NA hsa-miR-342-3p PRKAR1A 1.49115144672245 1.43879249744621e-07 -0.494707246064478 1.09832496534671e-05 miRanda -0.0995115859475151 1.24057096388708e-07 NA NA NA hsa-miR-590-3p PRKAR1A 2.59289455139753 1.03200520972022e-21 -0.494707246064478 1.09832496534671e-05 miRanda;mirMAP -0.0841522998475742 1.81567040243572e-05 NA NA NA hsa-miR-590-5p PRKAR1A 3.18300989862077 2.06813568597893e-26 -0.494707246064478 1.09832496534671e-05 miRanda -0.0941282814950952 6.4557854682977e-08 NA NA NA hsa-miR-664a-3p PRKAR1A 0.634721925861133 0.00520070178640421 -0.494707246064478 1.09832496534671e-05 mirMAP -0.0572206408467312 0.0179548287678573 NA NA NA hsa-miR-96-5p PRKAR1A 4.89433085814374 1.92000659886961e-31 -0.494707246064478 1.09832496534671e-05 miRNAWalker2_validate;TargetScan;miRNATAP -0.0646429768713072 1.26970479323285e-07 NA NA NA hsa-miR-103a-3p PRKAR2A 1.44083190496858 1.53799939616416e-13 -0.958058230501873 0.00166358416501506 miRNAWalker2_validate -0.350849310244118 1.94773064927018e-06 NA NA NA hsa-miR-106a-5p PRKAR2A 2.48882002962836 1.99757727374521e-12 -0.958058230501873 0.00166358416501506 mirMAP -0.0829242674706705 0.0421312002706923 NA NA NA hsa-miR-106b-5p PRKAR2A 2.46782146831112 1.36171495805632e-23 -0.958058230501873 0.00166358416501506 mirMAP -0.242653924640786 1.85440556319997e-05 NA NA NA hsa-miR-125a-5p PRKAR2A 0.599529391575274 0.0102300147180307 -0.958058230501873 0.00166358416501506 miRanda -0.37787946708526 1.5675108729139e-09 NA NA NA hsa-miR-140-5p PRKAR2A 0.844753502512594 3.73722278438606e-05 -0.958058230501873 0.00166358416501506 miRanda -0.197853314212427 0.00623596481680405 NA NA NA hsa-miR-148a-3p PRKAR2A 1.26728238710376 2.52325607402829e-06 -0.958058230501873 0.00166358416501506 mirMAP -0.173503602499007 0.00144323618557555 NA NA NA hsa-miR-148b-3p PRKAR2A 1.97815018171325 6.07715327281595e-26 -0.958058230501873 0.00166358416501506 mirMAP -0.308772207570419 3.36765416449186e-05 NA NA NA hsa-miR-16-5p PRKAR2A 1.75824877145857 1.68592440033108e-16 -0.958058230501873 0.00166358416501506 miRNAWalker2_validate -0.207299552214686 0.0020597428531192 NA NA NA hsa-miR-17-5p PRKAR2A 3.2710598467455 9.93128340539455e-27 -0.958058230501873 0.00166358416501506 mirMAP -0.213035467903906 2.30881349927684e-06 NA NA NA hsa-miR-182-5p PRKAR2A 3.53923166221814 5.07781258121574e-21 -0.958058230501873 0.00166358416501506 mirMAP -0.15304190547009 3.93441644995187e-05 NA NA NA hsa-miR-197-3p PRKAR2A 1.75733174019505 8.88576793100499e-13 -0.958058230501873 0.00166358416501506 miRNAWalker2_validate -0.19132087635181 0.00112031547705946 NA NA NA hsa-miR-20a-5p PRKAR2A 3.15577933619191 4.19753346442454e-25 -0.958058230501873 0.00166358416501506 mirMAP -0.262949466382429 5.45103485479054e-09 NA NA NA hsa-miR-20b-5p PRKAR2A 2.07706563022469 1.10107236083433e-05 -0.958058230501873 0.00166358416501506 mirMAP -0.0910726538757002 0.00325446366334549 NA NA NA hsa-miR-21-5p PRKAR2A 2.73773305747971 1.38864982139576e-43 -0.958058230501873 0.00166358416501506 mirMAP -0.260585514930639 0.000114596506486694 NA NA NA hsa-miR-25-3p PRKAR2A 1.36472605225697 4.83790725935681e-11 -0.958058230501873 0.00166358416501506 mirMAP -0.199840197599522 0.00445130930358387 NA NA NA hsa-miR-26b-5p PRKAR2A 0.885393662798425 3.2116297961629e-06 -0.958058230501873 0.00166358416501506 mirMAP -0.352489387774103 5.1180473461065e-06 NA NA NA hsa-miR-28-5p PRKAR2A 0.230152919654905 0.0742909586754846 -0.958058230501873 0.00166358416501506 miRanda -0.317354369876665 0.00743076146152275 NA NA NA hsa-miR-29a-5p PRKAR2A 1.46749674755271 3.34605004270294e-07 -0.958058230501873 0.00166358416501506 mirMAP -0.171509666685872 0.00142484408765363 NA NA NA hsa-miR-32-5p PRKAR2A 2.34056473219422 6.24134585974322e-20 -0.958058230501873 0.00166358416501506 mirMAP -0.164785528189658 0.00290913268502593 NA NA NA hsa-miR-320a PRKAR2A 0.438165828017084 0.0390159073347133 -0.958058230501873 0.00166358416501506 mirMAP -0.364222003224594 1.57087202982753e-07 NA NA NA hsa-miR-320b PRKAR2A 1.55692969039548 1.41071034251915e-08 -0.958058230501873 0.00166358416501506 mirMAP -0.199908717374264 0.00016060086703581 NA NA NA hsa-miR-342-5p PRKAR2A 1.74634624752902 3.89286511372155e-11 -0.958058230501873 0.00166358416501506 miRNATAP -0.245147904548481 7.00242952332571e-06 NA NA NA hsa-miR-3607-3p PRKAR2A 2.68532138541128 5.66716351955047e-14 -0.958058230501873 0.00166358416501506 mirMAP -0.168318445015138 4.10453820829504e-05 NA NA NA hsa-miR-361-5p PRKAR2A 0.971859117235239 5.30236555707088e-09 -0.958058230501873 0.00166358416501506 miRanda -0.193183161655923 0.0297877653345942 NA NA NA hsa-miR-3913-5p PRKAR2A 2.44353493655328 8.95279496632448e-15 -0.958058230501873 0.00166358416501506 mirMAP -0.201996350129065 1.42424912878332e-05 NA NA NA hsa-miR-582-3p PRKAR2A 0.00876844181512659 0.977126166214707 -0.958058230501873 0.00166358416501506 mirMAP -0.125770824276989 0.00964624611957725 NA NA NA hsa-miR-582-5p PRKAR2A 0.609226359812689 0.032988717891497 -0.958058230501873 0.00166358416501506 miRNATAP -0.204926721580595 7.24251105901293e-05 NA NA NA hsa-miR-590-5p PRKAR2A 3.18300989862077 2.06813568597893e-26 -0.958058230501873 0.00166358416501506 mirMAP -0.194427880221685 4.28778026268334e-05 NA NA NA hsa-miR-7-1-3p PRKAR2A 1.84950311431067 1.25300363397654e-13 -0.958058230501873 0.00166358416501506 mirMAP -0.173196690749086 0.00271404934063376 NA NA NA hsa-miR-708-3p PRKAR2A 2.80907765282502 3.07460722669281e-14 -0.958058230501873 0.00166358416501506 mirMAP -0.0988599692421547 0.0107953259678287 NA NA NA hsa-miR-769-3p PRKAR2A 2.19896922202687 5.69250370895053e-12 -0.958058230501873 0.00166358416501506 miRNAWalker2_validate -0.102240179808546 0.0286231702957129 NA NA NA hsa-miR-92a-3p PRKAR2A 2.06460102658973 1.44784291084757e-19 -0.958058230501873 0.00166358416501506 mirMAP -0.212779014359801 0.000625507145973245 NA NA NA hsa-miR-944 PRKAR2A 2.91186649218281 1.31574753528144e-06 -0.958058230501873 0.00166358416501506 mirMAP -0.0668463473645314 0.00761124962860001 NA NA NA hsa-let-7a-3p PRKAR2B 1.42015538786275 7.03375209382654e-13 -2.6424142214808 7.30155345842383e-13 mirMAP -0.413974785318944 4.57144286032067e-06 NA NA NA hsa-let-7b-3p PRKAR2B 0.868207752019623 1.30460056774366e-05 -2.6424142214808 7.30155345842383e-13 mirMAP -0.302979006252105 0.000989045305242101 NA NA NA hsa-let-7f-1-3p PRKAR2B 1.55054488387679 7.31326775537952e-11 -2.6424142214808 7.30155345842383e-13 mirMAP -0.215230558088131 0.00574393729251686 NA NA NA hsa-miR-107 PRKAR2B 1.30977326593435 1.30372468603965e-11 -2.6424142214808 7.30155345842383e-13 miRanda -0.231460940026043 0.0133239826950658 NA NA NA hsa-miR-186-5p PRKAR2B 1.47445398888668 3.0781726595413e-15 -2.6424142214808 7.30155345842383e-13 mirMAP -0.321761961201559 0.000772863763366889 NA NA NA hsa-miR-200b-3p PRKAR2B 3.78235093249346 3.18343003239465e-14 -2.6424142214808 7.30155345842383e-13 TargetScan -0.188581609073265 8.00246180754754e-08 NA NA NA hsa-miR-200c-3p PRKAR2B 3.50132673580082 2.42716349086937e-15 -2.6424142214808 7.30155345842383e-13 miRNATAP -0.267488379876048 7.71967366135021e-12 NA NA NA hsa-miR-3065-5p PRKAR2B 2.74629919868982 1.86846589298284e-08 -2.6424142214808 7.30155345842383e-13 miRNATAP -0.11341056331334 0.0122444126943186 NA NA NA hsa-miR-32-5p PRKAR2B 2.34056473219422 6.24134585974322e-20 -2.6424142214808 7.30155345842383e-13 miRNATAP -0.276859835292248 5.01298329302752e-05 NA NA NA hsa-miR-335-3p PRKAR2B 3.08791651139852 5.31309869723517e-12 -2.6424142214808 7.30155345842383e-13 mirMAP -0.203129063258021 2.53679260832495e-07 NA NA NA hsa-miR-34c-3p PRKAR2B 2.41359195938096 3.46966584087088e-10 -2.6424142214808 7.30155345842383e-13 PITA;miRNATAP -0.138453766267301 0.00421688779281111 NA NA NA hsa-miR-361-5p PRKAR2B 0.971859117235239 5.30236555707088e-09 -2.6424142214808 7.30155345842383e-13 miRanda -0.392322571223063 0.000345653351775711 NA NA NA hsa-miR-429 PRKAR2B 4.48815175680773 2.44117492218206e-17 -2.6424142214808 7.30155345842383e-13 PITA;miRanda;miRNATAP -0.186608189782453 1.14936297941293e-08 NA NA NA hsa-miR-450b-5p PRKAR2B 1.69244418548325 1.68064054148881e-10 -2.6424142214808 7.30155345842383e-13 mirMAP;miRNATAP -0.137048468131565 0.0441799949298598 NA NA NA hsa-miR-590-3p PRKAR2B 2.59289455139753 1.03200520972022e-21 -2.6424142214808 7.30155345842383e-13 miRNAWalker2_validate;miRanda -0.269901854229474 4.28450511206591e-05 NA NA NA hsa-miR-92a-3p PRKAR2B 2.06460102658973 1.44784291084757e-19 -2.6424142214808 7.30155345842383e-13 miRNATAP -0.464704311408613 9.32577627372663e-10 NA NA NA hsa-miR-944 PRKAR2B 2.91186649218281 1.31574753528144e-06 -2.6424142214808 7.30155345842383e-13 mirMAP -0.296024663700539 7.0750363003914e-24 NA NA NA hsa-miR-127-3p RIPK1 -0.6279281852298 0.0400829468424132 -0.323726292412104 0.00484264630910019 miRanda -0.0666155216328224 0.000228644247246619 NA NA NA hsa-miR-374a-3p RIPK1 0.533309330504947 0.00192918429705142 -0.323726292412104 0.00484264630910019 mirMAP -0.064520223021078 0.048372863326544 NA NA NA hsa-miR-421 RIPK1 1.17791565395543 6.78526676976629e-06 -0.323726292412104 0.00484264630910019 miRanda;mirMAP -0.0702585068939242 0.000847981474331101 NA NA NA hsa-miR-496 RIPK1 0.46914638405371 0.145980484291736 -0.323726292412104 0.00484264630910019 miRanda -0.0556116308771314 0.00155595831044226 NA NA NA hsa-miR-203a-3p TNF 3.12352008343999 9.49391438647189e-07 0.168287325738871 0.711715304997615 miRTarBase -0.111842196318691 0.000983994485349752 NA NA NA hsa-miR-320a TNF 0.438165828017084 0.0390159073347133 0.168287325738871 0.711715304997615 miRanda -0.394855461451853 0.0001481103227567 NA NA NA hsa-miR-361-5p TNF 0.971859117235239 5.30236555707088e-09 0.168287325738871 0.711715304997615 miRanda -0.363396990950332 0.00589234482466197 NA NA NA hsa-miR-429 TNF 4.48815175680773 2.44117492218206e-17 0.168287325738871 0.711715304997615 miRNATAP -0.169293563460319 1.87983425787946e-05 NA NA NA hsa-miR-340-5p TNFRSF10B 0.30282999308409 0.157744789519131 0.0854160195132305 0.697363353003698 miRNAWalker2_validate -0.130618058364656 0.00887614707841885 NA NA NA hsa-miR-361-5p TNFRSF10C 0.971859117235239 5.30236555707088e-09 -0.499439470720603 0.192162849023382 miRanda -0.259516100289945 0.019605241486501 NA NA NA hsa-miR-186-5p TNFRSF10D 1.47445398888668 3.0781726595413e-15 -1.21952127016643 0.000173029902186277 mirMAP -0.17896857256799 0.0307715580575795 NA NA NA hsa-miR-590-5p TNFRSF10D 3.18300989862077 2.06813568597893e-26 -1.21952127016643 0.000173029902186277 miRanda -0.104917038709611 0.0402849542401198 NA NA NA hsa-miR-29c-3p TNFRSF1A -0.00968972577705429 0.97099586346872 -0.091878962870898 0.598653562583393 MirTarget;miRNATAP -0.0792717292927637 0.0126141889734666 NA NA NA hsa-miR-590-3p TNFRSF1A 2.59289455139753 1.03200520972022e-21 -0.091878962870898 0.598653562583393 miRanda -0.0906430094161927 0.00287641674359409 NA NA NA hsa-miR-129-5p TNFSF10 -0.524170159980738 0.222582956006346 0.62151336306871 0.110711377947693 miRanda -0.171605377985452 0.000117006373445903 NA NA NA hsa-miR-139-5p TNFSF10 -1.52606598644743 1.20474151350665e-08 0.62151336306871 0.110711377947693 miRanda -0.245494690697579 0.000392669662957397 NA NA NA hsa-miR-33a-3p TNFSF10 1.72765312072219 1.51784443453521e-07 0.62151336306871 0.110711377947693 mirMAP -0.24294878555277 8.65859088331346e-05 NA NA NA hsa-miR-361-5p TNFSF10 0.971859117235239 5.30236555707088e-09 0.62151336306871 0.110711377947693 miRanda -0.438574912638159 9.76217270913905e-05 NA NA NA hsa-miR-429 TNFSF10 4.48815175680773 2.44117492218206e-17 0.62151336306871 0.110711377947693 miRanda -0.134275255476822 7.66062319152758e-05 NA NA NA hsa-miR-98-5p TNFSF10 1.11154309866014 1.24143909012085e-08 0.62151336306871 0.110711377947693 miRNAWalker2_validate -0.619752540788512 4.22417181054043e-11 NA NA NA hsa-miR-214-3p TP53 -0.176344800034733 0.642485503428886 0.17313275059387 0.48779406985331 miRNAWalker2_validate;miRTarBase -0.0879929457575404 0.00576688203655961 26335793;25738546;22927443;27422604 MicroRNA 214 Promotes Apoptosis in Canine Hemangiosarcoma by Targeting the COP1 p53 Axis; We identified COP1 which is a critical negative regulator of p53 as a novel direct target of miR-214; Furthermore p53 knockdown abolished the miR-214-COP1-mediated apoptosis; thus miR-214 and COP1 regulated apoptosis through controlling p53 in HSA; In conclusion miR-214 functioned as a tumor suppressor in canine hemangiosarcoma by inducing apoptosis through recovering the function of p53;microRNA 214 enhances the invasion ability of breast cancer cells by targeting p53; Furthermore p53 which has been reported to be downregulated in BC was predicted to be the target gene of miR-214 using bioinformatics software programs; Moreover luciferase reporter vectors were constructed and it was confirmed that p53 is a target of miR-214; Following the transfection of miR-214 into BC cells we found that the overexpression of miR-214 markedly enhanced cell invasion through the downregulation of p53 expression; By contrast the overexpression of p53 abrogated the effects of miR-214; In conclusion this study demonstrates that miR-214 functions as an oncogene in BC at least partly by promoting cell invasion through the downregulation of p53;Enforcing expression of miR-214 increases whereas knockdown of miR-214 decreases OCSC population and self-renewal as well as the Nanog level preferentially in wild-type p53 cell lines;miR 214 promotes apoptosis and sensitizes breast cancer cells to doxorubicin by targeting the RFWD2 p53 cascade; Remarkably restoration of miR-214 expression induces apoptosis and sensitizes the MCF7 cells sustaining wild-type p53 but not the p53 null MDA-MB-157 cells to doxorubicin; In conclusion miR-214 functions as a tumor suppressor by regulating the RFWD2-p53 cascade thus delivery of miR-214 analogs could be a potential adjunct therapy in breast cancer harboring wild type p53 ;;; sarcoma;breast cancer;ovarian cancer;breast cancer hsa-miR-221-3p TP53 0.451556679024397 0.0909808299917811 0.17313275059387 0.48779406985331 miRNAWalker2_validate -0.115825211031354 0.0105671893909646 20880178;24324033 Circulating miR 221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression; The correlation between miR-221 levels and protein levels of p53 CEA ER and PR clinicopathological features or overall survival was analyzed; The immunohistochemistry analysis demonstrates a significant correlation between plasma miR-221 level and p53 expression; The direct amplification of plasma miR-221 can be used as a potential noninvasive molecular marker for diagnosis and prognosis of CRC and is correlated with p53 expression;Interestingly miR-221 can activate the p53/mdm2 axis by inhibiting MDM2 and in turn p53 activation contributes to miR-221 enhanced expression; Moreover by modulating the p53 axis miR-221 impacts cell-cycle progression and apoptotic response to doxorubicin in hepatocellular carcinoma-derived cell lines; These data were confirmed in clinical specimens of hepatocellular carcinoma in which elevated miR-221 expression was associated with the simultaneous presence of wild-type p53 and DNA hypomethylation poor survival;worse prognosis;progression;drug resistance colorectal cancer;liver cancer hsa-miR-222-3p TP53 0.851783756239071 0.00266783568486918 0.17313275059387 0.48779406985331 miRNAWalker2_validate -0.116904656132339 0.00589565055970469 NA NA NA hsa-miR-324-3p TRADD 2.08739139768981 3.11885987067952e-13 0.654523627495593 9.31374791447117e-05 miRNATAP -0.107791208741327 9.21494516260199e-05 NA NA NA hsa-miR-125b-2-3p XIAP -1.83175829351767 2.94917958974528e-05 0.0185824727941606 0.900456705596673 mirMAP -0.068986973089532 2.57273420660549e-05 NA NA NA hsa-miR-125b-5p XIAP -1.16462950151259 0.000288900271798384 0.0185824727941606 0.900456705596673 miRNAWalker2_validate -0.134609008147354 6.17145452585339e-10 NA NA NA hsa-miR-140-3p XIAP 0.0608890720479334 0.727716871248724 0.0185824727941606 0.900456705596673 mirMAP -0.0916376618716535 0.0278327492197441 NA NA NA hsa-miR-142-5p XIAP 1.17581605694506 0.0018174701991234 0.0185824727941606 0.900456705596673 mirMAP;miRNATAP -0.0648820033940148 0.000573423539803553 NA NA NA hsa-miR-143-5p XIAP 0.374623042221941 0.168857981158196 0.0185824727941606 0.900456705596673 mirMAP -0.0874158389674923 0.000897364406171057 NA NA NA hsa-miR-146b-5p XIAP 1.75587235896724 1.15724631266659e-07 0.0185824727941606 0.900456705596673 mirMAP;miRNATAP -0.100792988978608 1.7835560220266e-06 NA NA NA hsa-miR-155-5p XIAP 1.20164021433135 0.00086170622431261 0.0185824727941606 0.900456705596673 MirTarget -0.0764263500614685 0.000100628517502386 26779627 Bioinformatic predictions the dual-luciferase reporter assay and western blot analysis were used to detect how miR-155 regulates X-linked inhibitor of apoptosis protein XIAP; Furthermore the results from the luciferase assays and western blot analysis identified XIAP as the direct target of miR-155; In addition introducing XIAP cDNA without a three prime untranslated region 3'-UTR rescued the miR-155 promotion of apoptosis; These results indicate that miR-155 mediates cisplatin-induced apoptosis by targeting XIAP in ovarian cancer cells and that miR-155 could be a potential therapeutic target to increase the efficiency of ovarian cancer interventions ovarian cancer hsa-miR-195-3p XIAP -0.658653229922836 0.0142127125129199 0.0185824727941606 0.900456705596673 mirMAP -0.109312331752852 5.17755048006399e-05 NA NA NA hsa-miR-19a-3p XIAP 3.42309334186656 3.02671914353412e-28 0.0185824727941606 0.900456705596673 mirMAP -0.0545370952818166 0.0114152600633907 NA NA NA hsa-miR-19b-3p XIAP 2.49529833021187 1.57028265846699e-23 0.0185824727941606 0.900456705596673 mirMAP -0.0548312373778768 0.0444009935433898 NA NA NA hsa-miR-26a-2-3p XIAP 0.823520019989974 0.00017092160823769 0.0185824727941606 0.900456705596673 mirMAP -0.103081650553247 0.0016975998669049 NA NA NA hsa-miR-29a-5p XIAP 1.46749674755271 3.34605004270294e-07 0.0185824727941606 0.900456705596673 mirMAP -0.0792153377176069 0.00231305845328066 NA NA NA hsa-miR-338-5p XIAP -0.577691606146419 0.0472212680542825 0.0185824727941606 0.900456705596673 MirTarget;mirMAP -0.051019843899449 0.04029518680719 NA NA NA hsa-miR-340-5p XIAP 0.30282999308409 0.157744789519131 0.0185824727941606 0.900456705596673 mirMAP;miRNATAP -0.0868516659003001 0.00993294704670108 NA NA NA hsa-miR-500a-5p XIAP 1.72110365584658 3.0807246212659e-10 0.0185824727941606 0.900456705596673 mirMAP;miRNATAP -0.07723947944116 0.00264910124056209 NA NA NA hsa-miR-766-3p XIAP 1.2456012547833 6.44584025471128e-06 0.0185824727941606 0.900456705596673 mirMAP -0.0589738595963076 0.0220523189556316 NA NA NA hsa-miR-92b-3p XIAP 1.20409245530001 3.41055816361655e-06 0.0185824727941606 0.900456705596673 mirMAP -0.0785656779092584 0.00413070154161394 NA NA NA