miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-101-3p AKT3 0.522819989585461 0.00375627731618038 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.334857831597034 0.000597756240419548 NA NA NA hsa-miR-106a-5p AKT3 2.48882002962836 1.99757727374521e-12 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.236478824223264 6.56988295029948e-07 NA NA NA hsa-miR-106b-5p AKT3 2.46782146831112 1.36171495805632e-23 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.521755012930227 1.0756262414999e-15 NA NA NA hsa-miR-107 AKT3 1.30977326593435 1.30372468603965e-11 -1.94162990884529 4.54380296394505e-08 PITA;miRanda -0.438321009170574 6.41595199298462e-07 NA NA NA hsa-miR-15a-5p AKT3 2.34669284378787 1.69544424500258e-23 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.653282073492048 2.38693369892811e-22 NA NA NA hsa-miR-15b-5p AKT3 1.57112623124278 9.14247846750597e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.4862313443712 1.80429141906685e-10 NA NA NA hsa-miR-16-5p AKT3 1.75824877145857 1.68592440033108e-16 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.527819854451446 1.06852141480407e-11 NA NA NA hsa-miR-17-3p AKT3 2.2704817679209 1.1667437320211e-22 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.393678889428456 2.72155279297878e-08 NA NA NA hsa-miR-17-5p AKT3 3.2710598467455 9.93128340539455e-27 -1.94162990884529 4.54380296394505e-08 TargetScan;miRNATAP -0.385876321416217 1.42856705542315e-13 NA NA NA hsa-miR-181a-5p AKT3 2.29556023480783 1.8138457900616e-21 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.283343247743329 3.77571043690309e-05 NA NA NA hsa-miR-181b-5p AKT3 2.49307679431293 3.92829250217627e-20 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.273550202394616 7.65012329836386e-06 NA NA NA hsa-miR-181c-5p AKT3 1.58587920618301 1.57506918816933e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.234902996176996 0.000670085449584041 NA NA NA hsa-miR-20a-5p AKT3 3.15577933619191 4.19753346442454e-25 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.397380097014522 3.56434655429537e-14 NA NA NA hsa-miR-20b-5p AKT3 2.07706563022469 1.10107236083433e-05 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.159136097484426 1.15057100055016e-05 NA NA NA hsa-miR-22-3p AKT3 1.21545661147757 1.61670170137775e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.356198759053997 0.000637369773108939 NA NA NA hsa-miR-29b-2-5p AKT3 0.910668640983475 0.00666655585493488 -1.94162990884529 4.54380296394505e-08 mirMAP -0.413342005890553 1.74596670459023e-16 NA NA NA hsa-miR-29b-3p AKT3 1.65828197923813 1.02676780888141e-09 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.328715384299769 1.41956551647306e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-29c-3p AKT3 -0.00968972577705429 0.97099586346872 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRNATAP -0.256484648428124 9.16722320814547e-05 NA NA NA hsa-miR-3065-5p AKT3 2.74629919868982 1.86846589298284e-08 -1.94162990884529 4.54380296394505e-08 mirMAP -0.196776388311872 4.09483787014971e-06 NA NA NA hsa-miR-32-3p AKT3 2.02436999565685 5.94091197945307e-09 -1.94162990884529 4.54380296394505e-08 mirMAP -0.274043726011417 8.75730973684685e-07 NA NA NA hsa-miR-320a AKT3 0.438165828017084 0.0390159073347133 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.539139659729602 3.01448987258332e-11 NA NA NA hsa-miR-320b AKT3 1.55692969039548 1.41071034251915e-08 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.376164976249955 1.04134326075959e-09 NA NA NA hsa-miR-335-3p AKT3 3.08791651139852 5.31309869723517e-12 -1.94162990884529 4.54380296394505e-08 mirMAP -0.222130607012057 2.63416728864213e-09 NA NA NA hsa-miR-33a-3p AKT3 1.72765312072219 1.51784443453521e-07 -1.94162990884529 4.54380296394505e-08 mirMAP -0.325733544419159 9.28241682908522e-09 NA NA NA hsa-miR-362-3p AKT3 2.0756816987665 3.89026064579331e-12 -1.94162990884529 4.54380296394505e-08 miRanda -0.16536843343699 0.0049777492806053 NA NA NA hsa-miR-362-5p AKT3 1.59303749908759 9.582675908797e-08 -1.94162990884529 4.54380296394505e-08 PITA;TargetScan;miRNATAP -0.201169258976553 0.000472996311050305 NA NA NA hsa-miR-374a-5p AKT3 0.484615721953736 0.0042981729815149 -1.94162990884529 4.54380296394505e-08 mirMAP -0.289501808595266 0.00547104114009117 NA NA NA hsa-miR-421 AKT3 1.17791565395543 6.78526676976629e-06 -1.94162990884529 4.54380296394505e-08 miRanda;mirMAP -0.270003673244585 4.40560995362011e-05 NA NA NA hsa-miR-501-3p AKT3 1.83132758513743 1.10971547702065e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.357094776714992 1.69773165528929e-09 NA NA NA hsa-miR-502-3p AKT3 1.50560877085049 1.2647489756373e-11 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.326505295822604 2.04961437337709e-05 NA NA NA hsa-miR-505-3p AKT3 1.45322244209148 8.86597629645867e-10 -1.94162990884529 4.54380296394505e-08 mirMAP -0.409352554521824 1.03207996907079e-08 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-769-5p AKT3 1.82023760596845 9.6815886564134e-14 -1.94162990884529 4.54380296394505e-08 PITA;miRNATAP -0.445071301297515 6.71512496875401e-11 NA NA NA hsa-miR-93-5p AKT3 3.03961860136032 1.11672209617395e-24 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.494281511913237 1.38435165024812e-20 NA NA NA hsa-miR-3065-5p ANGPT1 2.74629919868982 1.86846589298284e-08 -2.00320848939512 7.51234603738143e-06 mirMAP -0.157963248568316 0.00339143349189613 NA NA NA hsa-miR-335-3p ANGPT1 3.08791651139852 5.31309869723517e-12 -2.00320848939512 7.51234603738143e-06 mirMAP -0.13953242317373 0.00330172430492205 NA NA NA hsa-miR-361-5p ANGPT1 0.971859117235239 5.30236555707088e-09 -2.00320848939512 7.51234603738143e-06 miRanda -0.481765321687889 0.000227292206941834 NA NA NA hsa-miR-429 ANGPT1 4.48815175680773 2.44117492218206e-17 -2.00320848939512 7.51234603738143e-06 miRanda -0.315973268151069 1.29203633929802e-16 NA NA NA hsa-miR-486-5p ANGPT1 -0.194913133034028 0.607377798807705 -2.00320848939512 7.51234603738143e-06 miRanda -0.133413951010644 0.0209731552322753 NA NA NA hsa-miR-590-3p ANGPT1 2.59289455139753 1.03200520972022e-21 -2.00320848939512 7.51234603738143e-06 PITA;miRanda;mirMAP -0.26744477612574 0.00070073503661837 NA NA NA hsa-miR-944 ANGPT1 2.91186649218281 1.31574753528144e-06 -2.00320848939512 7.51234603738143e-06 PITA;mirMAP -0.161509415342341 1.10510037550753e-05 NA NA NA hsa-miR-142-5p ANGPT2 1.17581605694506 0.0018174701991234 0.162665171077281 0.565563993523621 MirTarget -0.190884775204089 8.65337750704999e-08 NA NA NA hsa-miR-145-5p ANGPT2 -1.55259331973517 9.97889123247165e-07 0.162665171077281 0.565563993523621 MirTarget;miRNATAP -0.171093797478721 5.43701253812128e-05 24384875;27570490 miR 145 functions as tumor suppressor and targets two oncogenes ANGPT2 and NEDD9 in renal cell carcinoma; We further validated those miR-145 targets two oncogenes ANGPT2 and NEDD9 in RCC;MiR 145 functions as a tumor suppressor via regulating angiopoietin 2 in pancreatic cancer cells; The direct action of miR-145 on Ang-2 was predicted by TargetScan and confirmed by luciferase report assay; The expression level of miR-145 was significantly lower and the expression levels of Ang-2 mRNA and protein was significantly higher in the more aggressive pancreatic cancer cells MiaPaCa-2 and Panc-1 when compared to that in BxPC3 cells; Overexpression of miR-145 in the BxPC3 MiaPaCa-2 and Panc-1 cells suppressed the cell invasion and colony formation ability and the expression level of Ang-2 protein in MiaPaCa-2 and Panc-1 cells was also suppressed after pre-miR-145 transfection; Intratumoral delivery of miR-145 inhibited the growth of pancreatic cancer xenografts and angiogenesis in vivo and also suppressed the expression level of angiopoietin-2 protein; MiR-145 functions as a tumor suppressor in pancreatic cancer cells by targeting Ang-2 for translation repression and thus suppresses pancreatic cancer cell invasion and growth which suggests that restoring of miR-145 may be a potential therapeutic target for pancreatic cancer ; kidney renal cell cancer;pancreatic cancer hsa-miR-299-5p ANGPT2 -0.274550626427337 0.386834031856446 0.162665171077281 0.565563993523621 miRNATAP -0.105630831440428 0.0149680039376856 NA NA NA hsa-miR-374a-5p ANGPT2 0.484615721953736 0.0042981729815149 0.162665171077281 0.565563993523621 mirMAP -0.180313994965832 0.0274326087685275 NA NA NA hsa-miR-374b-5p ANGPT2 0.0654362503857184 0.722673188879465 0.162665171077281 0.565563993523621 mirMAP -0.256937248555906 0.000620833356683864 NA NA NA hsa-miR-10b-5p ATF2 -0.155951595811628 0.555006386998027 -0.360334142061557 0.0913687862766104 MirTarget;miRNATAP -0.112522576994954 0.00414026865369324 NA NA NA hsa-miR-126-5p ATF2 0.895338176458417 2.33372756450713e-05 -0.360334142061557 0.0913687862766104 mirMAP -0.14881216970424 0.00223637271112211 NA NA NA hsa-miR-140-3p ATF2 0.0608890720479334 0.727716871248724 -0.360334142061557 0.0913687862766104 MirTarget;PITA;miRNATAP -0.204011014456392 0.000651503450345203 NA NA NA hsa-miR-15a-5p ATF2 2.34669284378787 1.69544424500258e-23 -0.360334142061557 0.0913687862766104 miRNAWalker2_validate -0.170687494407351 3.95479356045233e-05 NA NA NA hsa-miR-181a-5p ATF2 2.29556023480783 1.8138457900616e-21 -0.360334142061557 0.0913687862766104 mirMAP;miRNATAP -0.176303985611759 1.39870223725171e-05 NA NA NA hsa-miR-181b-5p ATF2 2.49307679431293 3.92829250217627e-20 -0.360334142061557 0.0913687862766104 mirMAP;miRNATAP -0.103909488174035 0.00428377219177581 NA NA NA hsa-miR-181c-5p ATF2 1.58587920618301 1.57506918816933e-10 -0.360334142061557 0.0913687862766104 mirMAP;miRNATAP -0.185195599739143 5.03828082080802e-06 NA NA NA hsa-miR-194-5p ATF2 1.8992998339217 3.76507853301977e-10 -0.360334142061557 0.0913687862766104 miRNATAP -0.107350599250521 0.00126943098471402 NA NA NA hsa-miR-19a-3p ATF2 3.42309334186656 3.02671914353412e-28 -0.360334142061557 0.0913687862766104 MirTarget;miRNATAP -0.127513126044015 3.6737554818488e-05 NA NA NA hsa-miR-19b-3p ATF2 2.49529833021187 1.57028265846699e-23 -0.360334142061557 0.0913687862766104 miRNAWalker2_validate;MirTarget;miRNATAP -0.159184178998869 4.56232246190828e-05 NA NA NA hsa-miR-26b-5p ATF2 0.885393662798425 3.2116297961629e-06 -0.360334142061557 0.0913687862766104 MirTarget;miRNATAP -0.190104058076874 0.000446414188712241 21901137 Coordinated regulation of ATF2 by miR 26b in γ irradiated lung cancer cells; Concurrent analysis of time-series mRNA and microRNA profiles uncovered that expression of miR-26b was down regulated and its target activating transcription factor 2 ATF2 mRNA was up regulated in γ-irradiated H1299 cells; IR in miR-26b overexpressed H1299 cells could not induce expression of ATF2; From these results we concluded that IR-induced up-regulation of ATF2 was coordinately enhanced by suppression of miR-26b in lung cancer cells which may enhance the effect of IR in the MAPK signaling pathway lung cancer hsa-miR-29a-5p ATF2 1.46749674755271 3.34605004270294e-07 -0.360334142061557 0.0913687862766104 MirTarget;miRNATAP -0.107282429424317 0.00424592492232286 NA NA NA hsa-miR-30a-5p ATF2 -0.878357906436456 0.000509952992366057 -0.360334142061557 0.0913687862766104 mirMAP -0.143058316365483 0.000436069853407003 NA NA NA hsa-miR-30b-5p ATF2 0.800822374912712 0.000133601914525413 -0.360334142061557 0.0913687862766104 mirMAP -0.208599821399784 2.06942579229443e-05 NA NA NA hsa-miR-30c-5p ATF2 0.778774633108 0.000285599212429136 -0.360334142061557 0.0913687862766104 mirMAP -0.302052934745697 1.60579370141006e-10 NA NA NA hsa-miR-30d-5p ATF2 0.675423997639582 0.00270618816039773 -0.360334142061557 0.0913687862766104 mirMAP -0.12763525078152 0.0054928443467875 NA NA NA hsa-miR-30e-5p ATF2 1.23904909539663 1.35561917122157e-09 -0.360334142061557 0.0913687862766104 mirMAP -0.250004980337073 4.19406363604627e-07 NA NA NA hsa-miR-320a ATF2 0.438165828017084 0.0390159073347133 -0.360334142061557 0.0913687862766104 miRanda -0.161156676452192 0.000977853785293753 NA NA NA hsa-miR-582-5p ATF2 0.609226359812689 0.032988717891497 -0.360334142061557 0.0913687862766104 MirTarget;miRNATAP -0.111875088913283 0.00195464990636449 NA NA NA hsa-miR-590-3p ATF2 2.59289455139753 1.03200520972022e-21 -0.360334142061557 0.0913687862766104 MirTarget;miRanda;mirMAP;miRNATAP -0.115458834968422 0.00194384711428695 NA NA NA hsa-let-7a-5p BCL2 0.618599506841644 2.76973453058748e-05 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate -0.227211670110314 0.0179425982768944 24643702;26915294 Estrogen combined with progesterone decreases cell proliferation and inhibits the expression of Bcl 2 via microRNA let 7a and miR 34b in ovarian cancer cells; Moreover the relative abundance of Bcl-2 and microRNAs let-7a miR-34b expressions were detected by quantitative real-time PCR qRT-PCR and Western blotting; E2 + P4 promoted the expression of let-7a and miR-34b and reduced the expression of Bcl-2 in ovarian cancer cells; When the expression of let-7a or/and miR-34b was inhibited using miRNA inhibitors E2 + P4 treatment did not change the protein level of Bcl-2; E2 + P4 significantly inhibited the cell survival promoted the cell apoptosis induced the expression of let-7a and miR-34b and reduced the expression of Bcl-2 in ovarian cancer cells;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively poor survival;poor survival ovarian cancer;lung cancer hsa-miR-103a-3p BCL2 1.44083190496858 1.53799939616416e-13 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate -0.316592082591341 5.34263132858783e-06 NA NA NA hsa-miR-125a-5p BCL2 0.599529391575274 0.0102300147180307 -2.02088083891464 5.5300725103229e-13 PITA -0.204181839304005 0.000647180620809067 NA NA NA hsa-miR-126-5p BCL2 0.895338176458417 2.33372756450713e-05 -2.02088083891464 5.5300725103229e-13 mirMAP -0.136813897862068 0.0382651228386025 NA NA NA hsa-miR-130b-5p BCL2 2.9963110846538 1.98883029416455e-18 -2.02088083891464 5.5300725103229e-13 mirMAP -0.257233532043175 6.21636254360678e-11 27364335 The level of microRNA-130b in relationship with the expression of PPARγ VEGF-A BCL-2 and apoptosis were analyzed in 91 lung cancer patient samples using immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL assay on tissue microarrays; In vitro and in vivo miR-130b enrichment associated with down-regulation of PPARγ up-regulation of VEGF-A and BCL-2 and decreased apoptosis lung cancer hsa-miR-15a-5p BCL2 2.34669284378787 1.69544424500258e-23 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.391979588821952 1.08722628903108e-12 25594541;26915294;18931683;25623762;22335947 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 ;poor survival;;drug resistance; breast cancer;lung cancer;prostate cancer;colon cancer;breast cancer hsa-miR-15b-3p BCL2 2.33847028227712 4.29662877950836e-19 -2.02088083891464 5.5300725103229e-13 mirMAP -0.323477257690888 1.09586549927814e-10 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-15b-5p BCL2 1.57112623124278 9.14247846750597e-13 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.256427911729671 3.30685638311642e-05 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-16-1-3p BCL2 2.56983217111073 3.02262181237943e-20 -2.02088083891464 5.5300725103229e-13 mirMAP -0.3266254366235 1.09255462667175e-11 18931683 MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2 prostate cancer hsa-miR-16-2-3p BCL2 2.31623086727196 4.29838149388188e-20 -2.02088083891464 5.5300725103229e-13 mirMAP -0.283819463467791 5.74174499512362e-08 NA NA NA hsa-miR-16-5p BCL2 1.75824877145857 1.68592440033108e-16 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.288487498854428 4.63144203616397e-06 21336967;24447552;18449891;25435430;24598659;18931683;22966344;25623762 P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells ;worse prognosis;drug resistance;;;;poor survival;drug resistance liver cancer;lymphoma;gastric cancer;lung cancer;lymphoma;prostate cancer;pancreatic cancer;colon cancer hsa-miR-17-5p BCL2 3.2710598467455 9.93128340539455e-27 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.293095808916295 2.47054725414332e-12 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-181a-5p BCL2 2.29556023480783 1.8138457900616e-21 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.302999442697681 2.70012636306699e-08 24267199;23740615;25524579;27534652;24335172 Bufalin was found to induce the expression of miR-181a a small non-coding RNA believed to induce apoptosis by repressing its target gene BCL-2; In prostate cancer PC-3cell line bufalin-induced apoptosis can be largely attenuated by a miR-181a inhibitor which blocked bufalin-induced Bcl-2 reduction and caspase-3 activation;The results from Western blotting indicated that miR-181a might be associated with the up-regulation of bcl-2 and matrix metalloproteinase 9 and the down-regulation of tissue inhibitor of metalloproteinases-3 and p21 in MG63 cells;Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression;In addition inhibition of miR-181a promoted apoptosis of HeLa and CaSKi cells due to increasing Bax expression and decreasing Bcl-2 expression;The function role of miR 181a in chemosensitivity to adriamycin by targeting Bcl 2 in low invasive breast cancer cells; Luciferase reporter vector with the putative BCL-2 3' untranslated region 3'UTR was constructed to explore whether BCL-2 was a direct target gene of miR-181a; Real-time PCR was performed to test the expression of miR-181a and Bcl-2 in the selected breast cancer tissue samples; Transfected with miR-181a mimic in cells resulted in the decreased expression of Bcl-2; At least in part the detection of miR-181a may direct the clinical medication in patients with neoadjuvant chemotherapy because of miR-181a enhanced adriamycin-induced apoptosis via targeting Bcl-2 ;;;; prostate cancer;sarcoma;lung squamous cell cancer;cervical and endocervical cancer;breast cancer hsa-miR-181b-5p BCL2 2.49307679431293 3.92829250217627e-20 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.305267910529038 2.57343031129337e-10 25524579 Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression lung squamous cell cancer hsa-miR-181c-5p BCL2 1.58587920618301 1.57506918816933e-10 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.112460550118007 0.0424640002427638 NA NA NA hsa-miR-181d-5p BCL2 1.52204912185579 9.2693319057748e-08 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.138340152158444 0.00425126630916248 NA NA NA hsa-miR-182-5p BCL2 3.53923166221814 5.07781258121574e-21 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;mirMAP -0.179869914139863 2.52267854475577e-07 23936432;26870290 Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR 182 and p21; Bcl2 and p21 were identified to be potential target genes of miR-182 in PC3 cells;The expression levels of B-cell lymphoma-2 Bcl-2 and microRNA-182 miR-182 were detected using western blot analysis and quantitative reverse transcription-polymerase chain reaction respectively; Mangiferin treatment was also able to significantly reduce Bcl-2 expression levels and enhance miR-182 expression in PC3 cells; Finally it was observed that mangiferin inhibited proliferation and induced apoptosis in PC3 human prostate cancer cells and this effect was correlated with downregulation of Bcl-2 and upregulation of miR-182 ; prostate cancer;B cell lymphoma hsa-miR-186-5p BCL2 1.47445398888668 3.0781726595413e-15 -2.02088083891464 5.5300725103229e-13 mirMAP -0.423453081728092 3.67590705887486e-09 NA NA NA hsa-miR-192-5p BCL2 2.69002528723195 1.22990188194432e-16 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate -0.208867066110207 3.33628652880772e-07 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-200a-5p BCL2 3.86316681673704 1.81076942093171e-15 -2.02088083891464 5.5300725103229e-13 mirMAP -0.15999187261028 4.28833785580744e-09 NA NA NA hsa-miR-200b-3p BCL2 3.78235093249346 3.18343003239465e-14 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;TargetScan;mirMAP -0.147905318391455 3.02424877197984e-08 NA NA NA hsa-miR-200b-5p BCL2 2.54484902707822 1.59240467582976e-06 -2.02088083891464 5.5300725103229e-13 mirMAP -0.136099351840362 2.8230250510626e-06 NA NA NA hsa-miR-200c-3p BCL2 3.50132673580082 2.42716349086937e-15 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;mirMAP -0.190113918290914 1.87463163361428e-10 NA NA NA hsa-miR-20a-3p BCL2 2.92621109947706 2.49504904635375e-17 -2.02088083891464 5.5300725103229e-13 mirMAP -0.210564396671593 8.96802878439544e-08 NA NA NA hsa-miR-20a-5p BCL2 3.15577933619191 4.19753346442454e-25 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.265706884379661 3.5423039457333e-10 NA NA NA hsa-miR-21-5p BCL2 2.73773305747971 1.38864982139576e-43 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.366618885310627 5.78881699391161e-09 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-224-5p BCL2 2.94107125335675 5.72194099515157e-08 -2.02088083891464 5.5300725103229e-13 mirMAP -0.119749067233376 1.76067406110872e-06 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-24-2-5p BCL2 2.07171035460647 3.15853539996136e-16 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.329656547931865 2.75296639271459e-10 NA NA NA hsa-miR-29a-5p BCL2 1.46749674755271 3.34605004270294e-07 -2.02088083891464 5.5300725103229e-13 mirMAP -0.213517369621975 2.31345511002058e-05 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29b-3p BCL2 1.65828197923813 1.02676780888141e-09 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.296891319533915 2.28427123681482e-09 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-3065-5p BCL2 2.74629919868982 1.86846589298284e-08 -2.02088083891464 5.5300725103229e-13 mirMAP -0.154823847891893 5.79242637365127e-06 NA NA NA hsa-miR-32-3p BCL2 2.02436999565685 5.94091197945307e-09 -2.02088083891464 5.5300725103229e-13 mirMAP -0.20244441600453 5.71853892832186e-06 NA NA NA hsa-miR-335-3p BCL2 3.08791651139852 5.31309869723517e-12 -2.02088083891464 5.5300725103229e-13 mirMAP -0.104382164677445 0.000555265264147089 NA NA NA hsa-miR-33a-5p BCL2 3.79671563098419 1.15966309820345e-18 -2.02088083891464 5.5300725103229e-13 mirMAP -0.197338268783918 2.87180137117656e-09 NA NA NA hsa-miR-34a-5p BCL2 1.9016323452565 1.43092834643601e-14 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.313298897109154 6.78995714898249e-09 24565525;23155233;24444609;20687223;22623155;24988056;18803879;19714243;25053345;20433755;21399894;22964582;23862748 In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression drug resistance;;poor survival;drug resistance;;;poor survival;differentiation;poor survival;drug resistance;;;; breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;breast cancer;gastric cancer;gastric cancer;pancreatic cancer;prostate cancer;colon cancer;breast cancer;lung cancer;liver cancer hsa-miR-365a-3p BCL2 -0.0388985816963467 0.859114494267351 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.26287248585935 3.91090481330584e-05 NA NA NA hsa-miR-429 BCL2 4.48815175680773 2.44117492218206e-17 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;PITA;mirMAP -0.154017674076185 5.15216313360141e-10 23999873;26513239;26511969 MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation ;; esophageal cancer;gastric cancer;glioblastoma hsa-miR-450b-5p BCL2 1.69244418548325 1.68064054148881e-10 -2.02088083891464 5.5300725103229e-13 mirMAP -0.195491457721654 0.000146490668566645 NA NA NA hsa-miR-452-5p BCL2 1.37180058737183 0.00171494843537772 -2.02088083891464 5.5300725103229e-13 mirMAP -0.104092924779063 0.00100591652628657 NA NA NA hsa-miR-455-5p BCL2 2.2582442061694 1.43472128037398e-13 -2.02088083891464 5.5300725103229e-13 mirMAP -0.296135324171891 8.75003372187937e-12 NA NA NA hsa-miR-582-5p BCL2 0.609226359812689 0.032988717891497 -2.02088083891464 5.5300725103229e-13 PITA -0.211866972823695 1.29345936711211e-05 NA NA NA hsa-miR-590-3p BCL2 2.59289455139753 1.03200520972022e-21 -2.02088083891464 5.5300725103229e-13 miRanda;mirMAP -0.268687896594515 6.89769791912093e-08 NA NA NA hsa-miR-590-5p BCL2 3.18300989862077 2.06813568597893e-26 -2.02088083891464 5.5300725103229e-13 miRanda -0.311666149337473 1.27642835632825e-12 NA NA NA hsa-miR-629-5p BCL2 2.10182419359635 1.51788571125757e-15 -2.02088083891464 5.5300725103229e-13 mirMAP -0.237720791875816 2.9555469743804e-06 NA NA NA hsa-miR-664a-5p BCL2 0.505019913598436 0.032933350691651 -2.02088083891464 5.5300725103229e-13 mirMAP -0.133435367665978 0.0249936816629116 NA NA NA hsa-miR-7-1-3p BCL2 1.84950311431067 1.25300363397654e-13 -2.02088083891464 5.5300725103229e-13 mirMAP -0.256930851687325 1.96074632615661e-06 NA NA NA hsa-miR-7-5p BCL2 2.28980165299999 1.5131097560452e-07 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;mirMAP -0.178441327891617 1.03482718248784e-07 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-miR-96-5p BCL2 4.89433085814374 1.92000659886961e-31 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;TargetScan -0.202123113149013 6.78873155803595e-11 NA NA NA hsa-let-7b-3p BDNF 0.868207752019623 1.30460056774366e-05 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.285067683917082 0.00912745906089909 NA NA NA hsa-miR-103a-3p BDNF 1.44083190496858 1.53799939616416e-13 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.513010583082046 2.18583657796716e-06 NA NA NA hsa-miR-107 BDNF 1.30977326593435 1.30372468603965e-11 -2.90846311399482 3.32327619207597e-11 MirTarget;PITA;miRanda;miRNATAP -0.301411719956826 0.00652496504590489 27498977 MicroRNA 107 inhibits tumor growth and metastasis by targeting the BDNF mediated PI3K/AKT pathway in human non small lung cancer; In addition BDNF expression was upregulated and inversely correlated with miR-107 in NSCLC tissues; Enforced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-107 on NSCLC proliferation migration and invasion; miR-107 overexpression or downregulation of BDNF was able to inhibit activation of PI3K/AKT signaling pathway; Taken together our findings present the first evidence that miR-107 could suppress NSCLC metastasis by targeting BDNF and indirectly regulating PI3K/AKT signaling pathway which might lead to a potential therapeutic strategy focusing on miR-107 and BDNF for human NSCLC metastasis lung cancer hsa-miR-10a-5p BDNF 1.15016989191194 0.00372037233992369 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.239868149823933 9.76923403527126e-06 NA NA NA hsa-miR-148a-5p BDNF 1.16173838132242 0.000148929299881612 -2.90846311399482 3.32327619207597e-11 mirMAP -0.14221689035579 0.0445380010608777 NA NA NA hsa-miR-15a-5p BDNF 2.34669284378787 1.69544424500258e-23 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.538797123359211 4.53591149420254e-10 26581909 MicroRNA 15a 5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF; BDNF was then overexpressed in HepG2 and SNU-182 cells to evaluate its selective effect on miR-15a-5p in HCC modulation; MiR-15a-5p selectively and negatively regulated BDNF at both gene and protein levels in HCC cells; Forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-15a-5p on HCC proliferation and cell division in vitro; Our study demonstrated that miR-15a-5p is a tumor suppressor in HCC and its regulation is through BDNF in HCC liver cancer hsa-miR-15b-5p BDNF 1.57112623124278 9.14247846750597e-13 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.337417459977062 0.000476250471995874 NA NA NA hsa-miR-16-5p BDNF 1.75824877145857 1.68592440033108e-16 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.404475155904508 3.95284638464173e-05 NA NA NA hsa-miR-182-5p BDNF 3.53923166221814 5.07781258121574e-21 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.304142174368882 2.036484274037e-08 NA NA NA hsa-miR-191-5p BDNF 2.30038190670664 9.93191704545938e-17 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.485298765179322 6.26143603678241e-11 NA NA NA hsa-miR-210-3p BDNF 6.07079758655679 2.22120227133377e-28 -2.90846311399482 3.32327619207597e-11 miRNAWalker2_validate;miRTarBase -0.237223359082858 5.07246234320821e-11 NA NA NA hsa-miR-22-3p BDNF 1.21545661147757 1.61670170137775e-13 -2.90846311399482 3.32327619207597e-11 miRNAWalker2_validate;miRTarBase -0.538030930409075 3.25374878143957e-05 NA NA NA hsa-miR-26b-3p BDNF 2.18464160365372 2.11543189388328e-18 -2.90846311399482 3.32327619207597e-11 MirTarget -0.444310109951697 8.07362790493106e-08 NA NA NA hsa-miR-29b-2-5p BDNF 0.910668640983475 0.00666655585493488 -2.90846311399482 3.32327619207597e-11 mirMAP -0.385323162445974 1.40825527826931e-09 NA NA NA hsa-miR-3065-3p BDNF 2.16221780121195 9.65525739884541e-09 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.207023369564498 0.000246555472230515 NA NA NA hsa-miR-3065-5p BDNF 2.74629919868982 1.86846589298284e-08 -2.90846311399482 3.32327619207597e-11 mirMAP;miRNATAP -0.168376118012365 0.00167095455996276 NA NA NA hsa-miR-30c-5p BDNF 0.778774633108 0.000285599212429136 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.452622492319709 7.0923627825397e-06 NA NA NA hsa-miR-30d-5p BDNF 0.675423997639582 0.00270618816039773 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.31555337460895 0.00110619099852774 NA NA NA hsa-miR-30e-5p BDNF 1.23904909539663 1.35561917122157e-09 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.710933428108993 4.68409714514429e-12 NA NA NA hsa-miR-330-3p BDNF 0.876747334239085 0.00073709016089703 -2.90846311399482 3.32327619207597e-11 MirTarget -0.350307363358734 2.52309207840318e-05 NA NA NA hsa-miR-339-5p BDNF 2.68710938429893 3.03134080808154e-16 -2.90846311399482 3.32327619207597e-11 miRanda -0.208909558420091 0.0010320906387239 NA NA NA hsa-miR-33a-3p BDNF 1.72765312072219 1.51784443453521e-07 -2.90846311399482 3.32327619207597e-11 mirMAP -0.189569900102124 0.00822808887496796 NA NA NA hsa-miR-361-5p BDNF 0.971859117235239 5.30236555707088e-09 -2.90846311399482 3.32327619207597e-11 PITA;miRanda;miRNATAP -0.549614574828476 2.2273701996563e-05 NA NA NA hsa-miR-3913-5p BDNF 2.44353493655328 8.95279496632448e-15 -2.90846311399482 3.32327619207597e-11 mirMAP -0.401161818585588 3.16401389217705e-09 NA NA NA hsa-miR-424-5p BDNF 1.61930224569578 1.89642549274994e-10 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.192007580487305 0.022534574345576 NA NA NA hsa-miR-452-3p BDNF 2.42521958420768 4.08754552781156e-07 -2.90846311399482 3.32327619207597e-11 MirTarget -0.15349375691044 0.000617556235812272 NA NA NA hsa-miR-452-5p BDNF 1.37180058737183 0.00171494843537772 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.159672549433471 0.00121343995890147 NA NA NA hsa-miR-589-3p BDNF 2.51971841868825 2.39125940264107e-11 -2.90846311399482 3.32327619207597e-11 MirTarget -0.19485326256731 0.00234458194019574 NA NA NA hsa-miR-589-5p BDNF 1.71990116752371 8.310889042056e-14 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.224905569516507 0.0147113947741604 NA NA NA hsa-miR-590-3p BDNF 2.59289455139753 1.03200520972022e-21 -2.90846311399482 3.32327619207597e-11 miRanda;mirMAP;miRNATAP -0.215106825481362 0.00623574226190281 NA NA NA hsa-miR-7-1-3p BDNF 1.84950311431067 1.25300363397654e-13 -2.90846311399482 3.32327619207597e-11 MirTarget -0.193550915307398 0.0228746281811433 NA NA NA hsa-miR-944 BDNF 2.91186649218281 1.31574753528144e-06 -2.90846311399482 3.32327619207597e-11 PITA;mirMAP;miRNATAP -0.210249837446185 6.49747993753151e-09 NA NA NA hsa-miR-320a BRCA1 0.438165828017084 0.0390159073347133 1.51897616703851 1.16936812791297e-12 miRanda -0.100171121697751 0.0474337910827283 NA NA NA hsa-miR-199a-3p CASP9 0.640600337515787 0.0380326905134914 -0.446359927280876 0.00400976702291555 mirMAP -0.146082132838509 1.00313136531724e-09 23319430 The techniques used were the MTT assay flow cytometry real-time PCR to assess miR-199a expression as also caspase-8 and caspase-9 activity in HepG2 cells treated with Propofol liver cancer hsa-miR-199b-3p CASP9 0.643923492750702 0.0371742251925406 -0.446359927280876 0.00400976702291555 mirMAP -0.146136089499986 9.60609442207656e-10 NA NA NA hsa-miR-222-5p CASP9 1.25632771414778 0.000138653440511922 -0.446359927280876 0.00400976702291555 mirMAP -0.126831808191525 1.31064720813193e-08 NA NA NA hsa-let-7i-5p CCND1 0.412877696970403 0.00622731051981756 0.0828319966762319 0.840332435689448 miRNATAP -0.284438698944636 0.0343513165460748 NA NA NA hsa-miR-106a-5p CCND1 2.48882002962836 1.99757727374521e-12 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.278915751904438 2.46069960202024e-07 NA NA NA hsa-miR-106b-5p CCND1 2.46782146831112 1.36171495805632e-23 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.190269381519641 0.0130099591661973 NA NA NA hsa-miR-1266-5p CCND1 1.3763848124288 0.000876906064212958 0.0828319966762319 0.840332435689448 MirTarget -0.105015097102923 0.0290668649868883 NA NA NA hsa-miR-15b-5p CCND1 1.57112623124278 9.14247846750597e-13 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.2743592470705 0.00190316455907807 NA NA NA hsa-miR-186-5p CCND1 1.47445398888668 3.0781726595413e-15 0.0828319966762319 0.840332435689448 mirMAP -0.319993507741074 0.0020448551843367 NA NA NA hsa-miR-193a-3p CCND1 1.60460546928078 2.86169793322984e-07 0.0828319966762319 0.840332435689448 MirTarget;PITA;miRanda -0.351734964348069 1.30056584701733e-08 NA NA NA hsa-miR-195-5p CCND1 -1.44753678070504 8.70594292149271e-09 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.232938095379387 0.00278406868271715 21350001;26631043;25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma ;;metastasis;poor survival breast cancer;cervical and endocervical cancer;sarcoma hsa-miR-19a-3p CCND1 3.42309334186656 3.02671914353412e-28 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase;miRNATAP -0.129855568478024 0.0302697285085785 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 2.57951428759379 4.31576118703427e-20 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase -0.152456226657987 0.0285260627618516 NA NA NA hsa-miR-19b-3p CCND1 2.49529833021187 1.57028265846699e-23 0.0828319966762319 0.840332435689448 miRNATAP -0.175038387630043 0.0207556361843719 NA NA NA hsa-miR-20b-5p CCND1 2.07706563022469 1.10107236083433e-05 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.250774310314038 8.20956147612201e-10 NA NA NA hsa-miR-338-3p CCND1 0.453166438193782 0.144583389707558 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase;miRanda -0.14528834655399 0.0235908904377559 NA NA NA hsa-miR-340-5p CCND1 0.30282999308409 0.157744789519131 0.0828319966762319 0.840332435689448 mirMAP -0.529085780655826 9.29072904979919e-09 NA NA NA hsa-miR-365a-3p CCND1 -0.0388985816963467 0.859114494267351 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase -0.20916008203635 0.0224869632381042 NA NA NA hsa-miR-374b-5p CCND1 0.0654362503857184 0.722673188879465 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;MirTarget -0.416222074203323 0.000132219455740898 NA NA NA hsa-miR-497-5p CCND1 0.0257087130056286 0.918145413833358 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.30773442281542 0.000110601843767413 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-589-3p CCND1 2.51971841868825 2.39125940264107e-11 0.0828319966762319 0.840332435689448 MirTarget -0.144538788730598 0.0136645647437734 NA NA NA hsa-miR-7-1-3p CCND1 1.84950311431067 1.25300363397654e-13 0.0828319966762319 0.840332435689448 mirMAP -0.247700635127977 0.00138754391814163 NA NA NA hsa-miR-769-3p CCND1 2.19896922202687 5.69250370895053e-12 0.0828319966762319 0.840332435689448 mirMAP -0.231146561837838 0.000210475786569237 NA NA NA hsa-miR-92a-3p CCND1 2.06460102658973 1.44784291084757e-19 0.0828319966762319 0.840332435689448 miRNAWalker2_validate -0.18696336621808 0.0257330648039561 NA NA NA hsa-let-7a-3p CCND2 1.42015538786275 7.03375209382654e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.440555668621489 2.14967330798537e-06 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7a-5p CCND2 0.618599506841644 2.76973453058748e-05 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.503238938401113 9.92586197811674e-05 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7b-3p CCND2 0.868207752019623 1.30460056774366e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.292600423696445 0.00203496813099611 NA NA NA hsa-let-7b-5p CCND2 0.604314269683977 0.00140009936153214 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.372644945722985 0.000202758514128247 NA NA NA hsa-let-7e-5p CCND2 0.860104282510173 6.04758298373779e-05 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.254279031336757 0.00390630067355032 NA NA NA hsa-let-7f-1-3p CCND2 1.55054488387679 7.31326775537952e-11 -2.42747067684236 2.06814828958882e-10 mirMAP -0.349075249109793 1.19776506071246e-05 NA NA NA hsa-let-7f-5p CCND2 0.495648727272215 0.00355972741198794 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.395067035409999 0.000431247614557398 NA NA NA hsa-let-7g-5p CCND2 1.20061455355116 1.50237505511483e-12 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.78482657734201 2.2934101130382e-13 NA NA NA hsa-miR-106a-5p CCND2 2.48882002962836 1.99757727374521e-12 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.460265785003224 1.90572227650597e-20 NA NA NA hsa-miR-106b-5p CCND2 2.46782146831112 1.36171495805632e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.723802321113981 4.62852843641777e-26 NA NA NA hsa-miR-10b-3p CCND2 0.77597971642517 0.00264877454133753 -2.42747067684236 2.06814828958882e-10 mirMAP -0.299055149155965 4.03151748542262e-05 NA NA NA hsa-miR-130b-5p CCND2 2.9963110846538 1.98883029416455e-18 -2.42747067684236 2.06814828958882e-10 mirMAP -0.524276006004661 2.15252650149472e-24 NA NA NA hsa-miR-141-3p CCND2 5.02396127982626 2.19224509139725e-24 -2.42747067684236 2.06814828958882e-10 MirTarget;TargetScan -0.336824974322951 8.46453268716016e-23 NA NA NA hsa-miR-151a-3p CCND2 1.24018761527407 1.08839919675408e-07 -2.42747067684236 2.06814828958882e-10 mirMAP -0.618872158164273 1.57062556462901e-15 NA NA NA hsa-miR-15a-5p CCND2 2.34669284378787 1.69544424500258e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.558385276567589 5.78612617845985e-14 NA NA NA hsa-miR-15b-5p CCND2 1.57112623124278 9.14247846750597e-13 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.814047353716774 1.36644748676197e-24 NA NA NA hsa-miR-16-2-3p CCND2 2.31623086727196 4.29838149388188e-20 -2.42747067684236 2.06814828958882e-10 mirMAP -0.524415153934827 5.42085565840902e-14 NA NA NA hsa-miR-16-5p CCND2 1.75824877145857 1.68592440033108e-16 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRNATAP -0.624880555696101 7.5948593080299e-14 NA NA NA hsa-miR-17-5p CCND2 3.2710598467455 9.93128340539455e-27 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.576586035201243 5.39762569803648e-26 NA NA NA hsa-miR-181a-2-3p CCND2 2.19062681262366 3.81790102612782e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.371385706331271 5.48097191184985e-10 NA NA NA hsa-miR-182-5p CCND2 3.53923166221814 5.07781258121574e-21 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.418107303561313 5.83833309647385e-20 NA NA NA hsa-miR-183-5p CCND2 4.19757025992371 4.79612296318304e-26 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.406097602561121 1.1832385157764e-21 NA NA NA hsa-miR-185-5p CCND2 2.34016206907488 1.17481626642022e-26 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.596214855521239 5.09732672184216e-14 NA NA NA hsa-miR-186-5p CCND2 1.47445398888668 3.0781726595413e-15 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.753228825405404 3.55444659312987e-15 NA NA NA hsa-miR-188-5p CCND2 2.52825126596644 6.78099435999778e-14 -2.42747067684236 2.06814828958882e-10 PITA;mirMAP -0.327199573697285 9.78244941189197e-09 NA NA NA hsa-miR-191-5p CCND2 2.30038190670664 9.93191704545938e-17 -2.42747067684236 2.06814828958882e-10 MirTarget -0.63056469865633 4.58280529094783e-24 NA NA NA hsa-miR-19a-3p CCND2 3.42309334186656 3.02671914353412e-28 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.478555105133488 2.03415225430867e-18 NA NA NA hsa-miR-19b-3p CCND2 2.49529833021187 1.57028265846699e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.644240893236217 5.93065810659583e-21 NA NA NA hsa-miR-200a-3p CCND2 4.59434485520731 6.38952518573476e-18 -2.42747067684236 2.06814828958882e-10 MirTarget -0.322639326506763 1.12744821991113e-23 NA NA NA hsa-miR-20a-5p CCND2 3.15577933619191 4.19753346442454e-25 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.552675029838617 1.98133209896024e-23 NA NA NA hsa-miR-20b-5p CCND2 2.07706563022469 1.10107236083433e-05 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.296015277168294 1.16933542500196e-14 NA NA NA hsa-miR-21-3p CCND2 2.19296355304364 4.63665722759779e-15 -2.42747067684236 2.06814828958882e-10 mirMAP -0.266420777851125 4.25531839718567e-05 NA NA NA hsa-miR-224-3p CCND2 1.87536386559317 6.15140969394846e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.234939524450716 1.27567539540633e-08 NA NA NA hsa-miR-26b-5p CCND2 0.885393662798425 3.2116297961629e-06 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.333191234288059 0.000785967313666436 NA NA NA hsa-miR-29b-3p CCND2 1.65828197923813 1.02676780888141e-09 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.181452610770389 0.00800883535071036 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-301a-3p CCND2 2.81024345929638 2.29784847962242e-17 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.490714440601798 1.13987935585442e-18 NA NA NA hsa-miR-3065-3p CCND2 2.16221780121195 9.65525739884541e-09 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.234083951058536 1.60505150894369e-06 NA NA NA hsa-miR-3065-5p CCND2 2.74629919868982 1.86846589298284e-08 -2.42747067684236 2.06814828958882e-10 mirMAP -0.236930159170796 2.73973057309239e-07 NA NA NA hsa-miR-30d-3p CCND2 0.977747550180601 4.3048212205381e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.514799428246913 2.69094766335815e-11 NA NA NA hsa-miR-30e-3p CCND2 -0.215663037684509 0.235375122783546 -2.42747067684236 2.06814828958882e-10 mirMAP -0.317748716556734 0.00256884077064715 NA NA NA hsa-miR-32-3p CCND2 2.02436999565685 5.94091197945307e-09 -2.42747067684236 2.06814828958882e-10 mirMAP -0.37065809204682 5.74913234109809e-10 NA NA NA hsa-miR-320a CCND2 0.438165828017084 0.0390159073347133 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;mirMAP;miRNATAP -0.366959333753783 3.90012764364419e-05 NA NA NA hsa-miR-320b CCND2 1.55692969039548 1.41071034251915e-08 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.389495451202309 5.62361965191887e-09 NA NA NA hsa-miR-324-3p CCND2 2.08739139768981 3.11885987067952e-13 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.569926030100518 1.57078270718816e-20 NA NA NA hsa-miR-331-5p CCND2 2.17414714166315 1.54547681391888e-18 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.55418360999634 4.24751797285043e-14 NA NA NA hsa-miR-335-5p CCND2 1.77247705492746 2.22457658872091e-06 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.196309653133352 7.59470226154717e-05 NA NA NA hsa-miR-33a-3p CCND2 1.72765312072219 1.51784443453521e-07 -2.42747067684236 2.06814828958882e-10 MirTarget -0.474892003832155 3.60158523540778e-15 NA NA NA hsa-miR-3607-3p CCND2 2.68532138541128 5.66716351955047e-14 -2.42747067684236 2.06814828958882e-10 mirMAP -0.253991708738003 1.1264040881505e-06 NA NA NA hsa-miR-374b-3p CCND2 0.930487774873495 2.74420094310516e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.379294826109076 7.61411367904561e-06 NA NA NA hsa-miR-378a-3p CCND2 -0.10995720000828 0.716188270032681 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.264766627168263 2.14263562743039e-05 NA NA NA hsa-miR-423-5p CCND2 0.963563145758616 9.86109015204915e-07 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.681308347713645 2.78087673863117e-13 NA NA NA hsa-miR-424-5p CCND2 1.61930224569578 1.89642549274994e-10 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.208747216207423 0.00424259734488207 NA NA NA hsa-miR-429 CCND2 4.48815175680773 2.44117492218206e-17 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.316889169500172 1.77696184266368e-22 NA NA NA hsa-miR-450b-5p CCND2 1.69244418548325 1.68064054148881e-10 -2.42747067684236 2.06814828958882e-10 MirTarget;PITA;miRNATAP -0.299286922863212 1.69011727706147e-05 NA NA NA hsa-miR-500a-5p CCND2 1.72110365584658 3.0807246212659e-10 -2.42747067684236 2.06814828958882e-10 mirMAP -0.230284164405623 0.000679591942778451 NA NA NA hsa-miR-501-5p CCND2 1.93654809410041 1.3779381780759e-10 -2.42747067684236 2.06814828958882e-10 PITA;mirMAP;miRNATAP -0.278516160908165 9.05358509837179e-06 NA NA NA hsa-miR-503-5p CCND2 3.66513190181895 6.60300917645278e-21 -2.42747067684236 2.06814828958882e-10 MirTarget -0.31264390956225 5.2815091282227e-11 25860935 We then identified two targets of miR-503 CCND2 and CCND3 breast cancer hsa-miR-550a-5p CCND2 2.11025227932763 6.94489556637146e-12 -2.42747067684236 2.06814828958882e-10 MirTarget -0.44540662591501 2.41152035101861e-14 NA NA NA hsa-miR-589-3p CCND2 2.51971841868825 2.39125940264107e-11 -2.42747067684236 2.06814828958882e-10 mirMAP -0.360588568041429 3.76015378643146e-11 NA NA NA hsa-miR-590-3p CCND2 2.59289455139753 1.03200520972022e-21 -2.42747067684236 2.06814828958882e-10 miRanda;mirMAP -0.419988530136573 3.79848108645639e-10 NA NA NA hsa-miR-590-5p CCND2 3.18300989862077 2.06813568597893e-26 -2.42747067684236 2.06814828958882e-10 mirMAP -0.50562344923364 6.73026539304424e-18 NA NA NA hsa-miR-660-5p CCND2 1.82692095272076 1.92040083607196e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.361636929774302 8.5078492819456e-07 NA NA NA hsa-miR-7-1-3p CCND2 1.84950311431067 1.25300363397654e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.518854235917429 5.32697612805784e-13 NA NA NA hsa-miR-708-3p CCND2 2.80907765282502 3.07460722669281e-14 -2.42747067684236 2.06814828958882e-10 mirMAP -0.177604972093223 0.000316375213374722 NA NA NA hsa-miR-708-5p CCND2 3.38051631555486 5.12590198690777e-18 -2.42747067684236 2.06814828958882e-10 mirMAP -0.19367896307831 2.62089031491477e-05 NA NA NA hsa-miR-877-5p CCND2 2.94916202082736 1.8151927276044e-13 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.361363420346396 6.83899428438154e-13 NA NA NA hsa-miR-93-5p CCND2 3.03961860136032 1.11672209617395e-24 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.640135233296746 3.73391346199191e-30 NA NA NA hsa-miR-944 CCND2 2.91186649218281 1.31574753528144e-06 -2.42747067684236 2.06814828958882e-10 PITA;mirMAP -0.168575408637895 9.32931241492905e-08 NA NA NA hsa-miR-96-5p CCND2 4.89433085814374 1.92000659886961e-31 -2.42747067684236 2.06814828958882e-10 TargetScan;miRNATAP -0.382951897231727 7.25785958201884e-21 NA NA NA hsa-miR-27b-3p CCND3 0.196007704287769 0.295630157035388 0.142518749044219 0.397307080616203 miRNAWalker2_validate -0.133645004740845 0.00231237621077374 NA NA NA hsa-miR-28-3p CCNE2 -0.411384408160536 0.0101470262574251 2.48639159684199 1.03709868150437e-14 PITA;miRNATAP -0.310525624419087 0.00235062649082895 NA NA NA hsa-miR-23b-3p CDK2 -0.251132426825047 0.150200321210792 0.937881089752417 5.53579780631165e-08 miRNAWalker2_validate -0.108170361258168 0.0284026530581814 NA NA NA hsa-miR-101-3p CDK6 0.522819989585461 0.00375627731618038 -0.774202349805119 0.064787030605636 mirMAP -0.728162460077577 6.25283110395347e-11 NA NA NA hsa-miR-103a-3p CDK6 1.44083190496858 1.53799939616416e-13 -0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRNATAP -0.738308002788887 9.81610683337994e-14 NA NA NA hsa-miR-106a-5p CDK6 2.48882002962836 1.99757727374521e-12 -0.774202349805119 0.064787030605636 mirMAP -0.23817017599031 1.76828696872453e-05 NA NA NA hsa-miR-106b-5p CDK6 2.46782146831112 1.36171495805632e-23 -0.774202349805119 0.064787030605636 mirMAP -0.506703206296417 3.6460930000884e-11 NA NA NA hsa-miR-107 CDK6 1.30977326593435 1.30372468603965e-11 -0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase;PITA;miRNATAP -0.535825292120497 1.58523365512466e-07 19407485;22491216;21264532;19688090 Enforced expression of miR-107 in MiaPACA-2 and PANC-1 cells downregulated in vitro growth and this was associated with repression of the putative miR-107 target cyclin-dependent kinase 6 thereby providing a functional basis for the epigenetic inactivation of this miRNA in pancreatic cancer;Levels of known miR-107 targets protein kinase Cε PKCε cyclin-dependent kinase 6 CDK6 and hypoxia-inducible factor 1-β HIF1-β decreased following NP/pre-miR-107 treatment;We have identified miR-107 as a potential regulator of CDK6 expression; A bioinformatics search revealed a putative target site for miR-107 within the CDK6 3' untranslated region; Expression of miR-107 in gastric cancer cell lines was found inversely correlated with CDK6 expression; miR-107 could significantly suppress CDK6 3' UTR luciferase reporter activity and this effect was not detectable when the putative 3' UTR target site was mutated; Consistent with the results of the reporter assay ectopic expression of miR-107 reduced both mRNA and protein expression levels of CDK6 inhibited proliferation induced G1 cell cycle arrest and blocked invasion of the gastric cancer cells; Our results suggest that miR-107 may have a tumor suppressor function by directly targeting CDK6 to inhibit the proliferation and invasion activities of gastric cancer cells;Using miRNA-target prediction analyses and the array data we listed up a set of likely targets of miR-107 and miR-185 for G1 cell cycle arrest and validate a subset of them using real-time RT-PCR and immunoblotting for CDK6 ;;; pancreatic cancer;head and neck cancer;gastric cancer;lung squamous cell cancer hsa-miR-140-3p CDK6 0.0608890720479334 0.727716871248724 -0.774202349805119 0.064787030605636 miRNATAP -0.253248000876385 0.0322057044568859 NA NA NA hsa-miR-141-3p CDK6 5.02396127982626 2.19224509139725e-24 -0.774202349805119 0.064787030605636 TargetScan;miRNATAP -0.280860480145549 9.29496321423746e-14 NA NA NA hsa-miR-148b-3p CDK6 1.97815018171325 6.07715327281595e-26 -0.774202349805119 0.064787030605636 mirMAP -0.689303354555952 6.39464837566244e-12 NA NA NA hsa-miR-148b-5p CDK6 2.18024067300781 2.84770452413262e-14 -0.774202349805119 0.064787030605636 mirMAP -0.337506526013873 2.86415828815712e-06 NA NA NA hsa-miR-15a-5p CDK6 2.34669284378787 1.69544424500258e-23 -0.774202349805119 0.064787030605636 miRNATAP -0.331153083238962 5.09100262040034e-05 NA NA NA hsa-miR-16-1-3p CDK6 2.56983217111073 3.02262181237943e-20 -0.774202349805119 0.064787030605636 mirMAP -0.214448709710321 0.00270430071750274 NA NA NA hsa-miR-16-5p CDK6 1.75824877145857 1.68592440033108e-16 -0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase -0.211183753760106 0.0224108751050014 NA NA NA hsa-miR-17-5p CDK6 3.2710598467455 9.93128340539455e-27 -0.774202349805119 0.064787030605636 TargetScan;mirMAP -0.168193833076577 0.00702167500067962 NA NA NA hsa-miR-182-5p CDK6 3.53923166221814 5.07781258121574e-21 -0.774202349805119 0.064787030605636 mirMAP -0.342809938093979 8.28135113019132e-12 NA NA NA hsa-miR-185-5p CDK6 2.34016206907488 1.17481626642022e-26 -0.774202349805119 0.064787030605636 miRNAWalker2_validate -0.418001590004214 1.44577313582161e-06 19688090 Using miRNA-target prediction analyses and the array data we listed up a set of likely targets of miR-107 and miR-185 for G1 cell cycle arrest and validate a subset of them using real-time RT-PCR and immunoblotting for CDK6 lung squamous cell cancer hsa-miR-191-5p CDK6 2.30038190670664 9.93191704545938e-17 -0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase -0.711524835034044 1.00464473356187e-26 NA NA NA hsa-miR-200a-3p CDK6 4.59434485520731 6.38952518573476e-18 -0.774202349805119 0.064787030605636 miRNATAP -0.336691687165474 2.80396820395637e-22 24009066 microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6 liver cancer hsa-miR-200b-3p CDK6 3.78235093249346 3.18343003239465e-14 -0.774202349805119 0.064787030605636 mirMAP -0.361406013032565 5.1342063993974e-22 NA NA NA hsa-miR-200c-3p CDK6 3.50132673580082 2.42716349086937e-15 -0.774202349805119 0.064787030605636 mirMAP -0.320385878451071 9.82419842455136e-14 NA NA NA hsa-miR-20a-5p CDK6 3.15577933619191 4.19753346442454e-25 -0.774202349805119 0.064787030605636 mirMAP -0.188851341814342 0.00261077138275469 NA NA NA hsa-miR-20b-5p CDK6 2.07706563022469 1.10107236083433e-05 -0.774202349805119 0.064787030605636 mirMAP -0.293918462449454 1.28039252847365e-12 26166554 The transfection of miR-20b into EJ cells induced G1 phase cell cycle arrest via the decreased expression of cyclin D1 CDK2 and CDK6 without affecting another G1 phase cell cycle regulator cyclin E bladder cancer hsa-miR-218-5p CDK6 -0.573801507392184 0.0551983860126703 -0.774202349805119 0.064787030605636 miRNAWalker2_validate -0.153512643208175 0.0240408053920225 23996750 Ectopic expression of miR-218 in HepG2 cells resulted in suppressed cell proliferation and enhanced cell apoptosis as well as the down-regulation of Bmi-1 and CDK6 mRNA and protein expressions P<0.05; The low-expression of miR-218 is correlated with malignant clinicopathological characteristics of HCC and miR-218 may inhibit cell proliferation and promote cell apoptosis by down-regulating Bmi-1 and CDK6 in HCC malignant trasformation liver cancer hsa-miR-29b-3p CDK6 1.65828197923813 1.02676780888141e-09 -0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase;miRNATAP -0.224461155748557 0.0022317971289129 23245396;25472644;26180082;23591808;27230400;20086245 The IFN-γ-induced G1-arrest of melanoma cells involves down-regulation of CDK6 which we proved to be a direct target of miR-29 in these cells;Moreover miR-29b inhibited the expression of MCL1 and CDK6;Knockdown of NTSR1 increased the expression of miR-29b-1 and miR-129-3p which were responsible for the decreased CDK6 expression;Here we have identified the oncogene cyclin-dependent protein kinase 6 CDK6 as a direct target of miR-29b in lung cancer;MiR 29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6; In this study we investigated the role of miR-29b as a novel regulator of CDK6 using bioinformatics methods; We demonstrated that CDK6 can be downregulated by miR-29b via binding to the 3'-UTR region in osteosarcoma cells; Furthermore we identified an inverse correlation between miR-29b and CDK6 protein levels in osteosarcoma tissues; The results revealed that miR-29b acts as a tumor suppressor of osteosarcoma by targeting CDK6 in the proliferation and migration processes;microRNA expression profile and identification of miR 29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma; Furthermore we demonstrate miR-29 inhibition of CDK6 protein and mRNA levels by direct binding to 3'-untranslated region; Inverse correlation between miR-29 and CDK6 was observed in MCL ;;;;; melanoma;colorectal cancer;glioblastoma;lung cancer;sarcoma;lymphoma hsa-miR-29c-3p CDK6 -0.00968972577705429 0.97099586346872 -0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase;miRNATAP -0.580639861705711 5.15109801814716e-15 26396669 Furthermore through qPCR and Western blot assays confirmed that overexpression of miR-29c reduced CDK6 mRNA and protein levels; miR-29c could inhibit the proliferation migration and invasion of bladder cancer cells via regulating CDK6 bladder cancer hsa-miR-3065-5p CDK6 2.74629919868982 1.86846589298284e-08 -0.774202349805119 0.064787030605636 mirMAP -0.118059295420914 0.0185164517615316 NA NA NA hsa-miR-30b-5p CDK6 0.800822374912712 0.000133601914525413 -0.774202349805119 0.064787030605636 mirMAP -0.540189292799148 1.61932566833175e-08 NA NA NA hsa-miR-30c-5p CDK6 0.778774633108 0.000285599212429136 -0.774202349805119 0.064787030605636 mirMAP -0.727075100437403 2.31302505595533e-15 NA NA NA hsa-miR-30d-3p CDK6 0.977747550180601 4.3048212205381e-05 -0.774202349805119 0.064787030605636 mirMAP -0.561334088800932 1.30656981501796e-11 NA NA NA hsa-miR-30d-5p CDK6 0.675423997639582 0.00270618816039773 -0.774202349805119 0.064787030605636 mirMAP -0.785477623920694 1.19356262091604e-19 NA NA NA hsa-miR-30e-3p CDK6 -0.215663037684509 0.235375122783546 -0.774202349805119 0.064787030605636 mirMAP -0.686700064203411 6.84849442105303e-10 NA NA NA hsa-miR-30e-5p CDK6 1.23904909539663 1.35561917122157e-09 -0.774202349805119 0.064787030605636 mirMAP -0.817058326987529 5.2385475320723e-18 NA NA NA hsa-miR-32-3p CDK6 2.02436999565685 5.94091197945307e-09 -0.774202349805119 0.064787030605636 mirMAP -0.249929478125797 0.000125097299153361 NA NA NA hsa-miR-32-5p CDK6 2.34056473219422 6.24134585974322e-20 -0.774202349805119 0.064787030605636 miRNATAP -0.295032649435311 9.55907730341779e-05 NA NA NA hsa-miR-320a CDK6 0.438165828017084 0.0390159073347133 -0.774202349805119 0.064787030605636 PITA;miRNATAP -0.376224025256019 8.78451776886182e-05 NA NA NA hsa-miR-320b CDK6 1.55692969039548 1.41071034251915e-08 -0.774202349805119 0.064787030605636 PITA;miRNATAP -0.1670921083766 0.0221331057182552 NA NA NA hsa-miR-330-3p CDK6 0.876747334239085 0.00073709016089703 -0.774202349805119 0.064787030605636 PITA;mirMAP -0.427895514362065 2.76679372346252e-08 NA NA NA hsa-miR-335-3p CDK6 3.08791651139852 5.31309869723517e-12 -0.774202349805119 0.064787030605636 mirMAP -0.153251191165497 0.000493500059209 NA NA NA hsa-miR-335-5p CDK6 1.77247705492746 2.22457658872091e-06 -0.774202349805119 0.064787030605636 mirMAP -0.166621089394833 0.00183832978506415 NA NA NA hsa-miR-33a-5p CDK6 3.79671563098419 1.15966309820345e-18 -0.774202349805119 0.064787030605636 miRNATAP -0.187324589024782 0.000129271884100387 NA NA NA hsa-miR-34a-3p CDK6 1.75590866103657 8.02801510630657e-09 -0.774202349805119 0.064787030605636 mirMAP -0.376950684687892 1.73963312821001e-07 21702042;26104764 Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004 ; bladder cancer;lung cancer hsa-miR-34a-5p CDK6 1.9016323452565 1.43092834643601e-14 -0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase;miRNATAP -0.519263514540718 3.07288169543583e-11 21702042;26104764 Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004 ; bladder cancer;lung cancer hsa-miR-3613-5p CDK6 2.64358387329263 1.0373753017245e-24 -0.774202349805119 0.064787030605636 miRNATAP -0.21181572504448 0.005712534663484 NA NA NA hsa-miR-362-5p CDK6 1.59303749908759 9.582675908797e-08 -0.774202349805119 0.064787030605636 mirMAP -0.313855526332272 2.37748256302272e-06 NA NA NA hsa-miR-374a-3p CDK6 0.533309330504947 0.00192918429705142 -0.774202349805119 0.064787030605636 mirMAP -0.273738714505887 0.0220682181270635 NA NA NA hsa-miR-378a-3p CDK6 -0.10995720000828 0.716188270032681 -0.774202349805119 0.064787030605636 mirMAP -0.397192555694478 2.01427891085214e-09 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-421 CDK6 1.17791565395543 6.78526676976629e-06 -0.774202349805119 0.064787030605636 mirMAP;miRNATAP -0.178411637766622 0.0211068498205428 NA NA NA hsa-miR-425-5p CDK6 3.07071373939774 4.02947460586085e-25 -0.774202349805119 0.064787030605636 mirMAP -0.484163394229156 1.07269848409271e-14 NA NA NA hsa-miR-429 CDK6 4.48815175680773 2.44117492218206e-17 -0.774202349805119 0.064787030605636 mirMAP;miRNATAP -0.337479964584767 4.50509176972113e-22 NA NA NA hsa-miR-450b-5p CDK6 1.69244418548325 1.68064054148881e-10 -0.774202349805119 0.064787030605636 mirMAP -0.201384976718992 0.00743415077141657 NA NA NA hsa-miR-497-5p CDK6 0.0257087130056286 0.918145413833358 -0.774202349805119 0.064787030605636 miRNATAP -0.245332138327252 0.00264647539053154 NA NA NA hsa-miR-500a-5p CDK6 1.72110365584658 3.0807246212659e-10 -0.774202349805119 0.064787030605636 mirMAP -0.232725295393576 0.00140479513304275 NA NA NA hsa-miR-501-3p CDK6 1.83132758513743 1.10971547702065e-10 -0.774202349805119 0.064787030605636 PITA;TargetScan;miRNATAP -0.414303056979818 1.84547250783893e-09 NA NA NA hsa-miR-502-3p CDK6 1.50560877085049 1.2647489756373e-11 -0.774202349805119 0.064787030605636 PITA;miRNATAP -0.4275399463222 1.5008131463888e-06 NA NA NA hsa-miR-590-5p CDK6 3.18300989862077 2.06813568597893e-26 -0.774202349805119 0.064787030605636 mirMAP;miRNATAP -0.201344503599928 0.00209551899019727 NA NA NA hsa-miR-592 CDK6 1.51765968871077 0.000636335248013204 -0.774202349805119 0.064787030605636 mirMAP -0.143284258807414 0.0019385912538056 NA NA NA hsa-miR-660-5p CDK6 1.82692095272076 1.92040083607196e-13 -0.774202349805119 0.064787030605636 mirMAP -0.339962414215247 1.75914031108584e-05 NA NA NA hsa-miR-664a-3p CDK6 0.634721925861133 0.00520070178640421 -0.774202349805119 0.064787030605636 mirMAP -0.700489354678287 6.77094321174664e-16 NA NA NA hsa-miR-671-5p CDK6 2.97733652243246 1.21148452344738e-23 -0.774202349805119 0.064787030605636 PITA;miRNATAP -0.255214929025129 0.000181908946141654 NA NA NA hsa-miR-92a-3p CDK6 2.06460102658973 1.44784291084757e-19 -0.774202349805119 0.064787030605636 miRNATAP -0.240406113182612 0.00492937850760914 NA NA NA hsa-miR-93-5p CDK6 3.03961860136032 1.11672209617395e-24 -0.774202349805119 0.064787030605636 mirMAP -0.467996685199197 1.00999249823312e-13 NA NA NA hsa-let-7d-5p CDKN1A 1.33236798905207 1.1741085658466e-13 -1.29236263370998 3.21238784768704e-06 MirTarget -0.324235774348598 1.11339571601414e-05 NA NA NA hsa-let-7f-5p CDKN1A 0.495648727272215 0.00355972741198794 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;MirTarget -0.24004761105408 0.00296779895445168 NA NA NA hsa-let-7g-5p CDKN1A 1.20061455355116 1.50237505511483e-12 -1.29236263370998 3.21238784768704e-06 MirTarget -0.261596530769954 0.000909666186900533 NA NA NA hsa-miR-101-3p CDKN1A 0.522819989585461 0.00375627731618038 -1.29236263370998 3.21238784768704e-06 MirTarget -0.196450098291035 0.00981579805828264 NA NA NA hsa-miR-106a-5p CDKN1A 2.48882002962836 1.99757727374521e-12 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.128693729012364 0.000550088861161385 25510666 After prediction with online software we further used dual-luciferase reporter gene assay to ensure that TP53INP1 and CDKN1A might be the direct targets of miR-106a liver cancer hsa-miR-106b-5p CDKN1A 2.46782146831112 1.36171495805632e-23 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.301959313712314 4.48472102839421e-09 NA NA NA hsa-miR-17-5p CDKN1A 3.2710598467455 9.93128340539455e-27 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.172861511846616 3.07251784468708e-05 26482648;24989082 The low expressions of miR-17 and miR-92 families can maintain cisplatin resistance through the regulation of CDKN1A and RAD21;According to PicTar and Miranda algorithms which predicted CDKN1A p21 as a putative target of miR-17 a luciferase assay was performed and revealed that miR-17 directly targets the 3'-UTR of p21 mRNA drug resistance; lung squamous cell cancer;sarcoma hsa-miR-182-5p CDKN1A 3.53923166221814 5.07781258121574e-21 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate -0.109364926293111 0.00141758512280426 NA NA NA hsa-miR-20a-5p CDKN1A 3.15577933619191 4.19753346442454e-25 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.165884225022855 7.19614215488726e-05 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex colon cancer hsa-miR-20b-5p CDKN1A 2.07706563022469 1.10107236083433e-05 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.112000786094038 7.41332851839187e-05 NA NA NA hsa-miR-28-5p CDKN1A 0.230152919654905 0.0742909586754846 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.556544696034112 2.23374029772338e-07 NA NA NA hsa-miR-30b-3p CDKN1A 0.834142820354026 0.000972582820878813 -1.29236263370998 3.21238784768704e-06 MirTarget -0.188277179739766 0.000464764881340986 NA NA NA hsa-miR-335-5p CDKN1A 1.77247705492746 2.22457658872091e-06 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate -0.15287461273454 1.73689594092226e-05 NA NA NA hsa-miR-345-5p CDKN1A 3.63532310411307 2.2698112107996e-21 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget -0.214757145120261 7.64097376843956e-11 NA NA NA hsa-miR-363-3p CDKN1A 1.50575300026701 0.00020976164678918 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase -0.119979037678532 0.000289602460917026 NA NA NA hsa-miR-423-3p CDKN1A 2.57855385753676 9.19765570228097e-24 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase -0.200481634838583 5.95960562762572e-05 NA NA NA hsa-miR-423-5p CDKN1A 0.963563145758616 9.86109015204915e-07 -1.29236263370998 3.21238784768704e-06 MirTarget -0.179252711950689 0.00923809529808823 NA NA NA hsa-miR-491-5p CDKN1A 0.615770352820862 0.0418295628761654 -1.29236263370998 3.21238784768704e-06 miRanda -0.127626893732512 0.00809072721464231 NA NA NA hsa-miR-503-5p CDKN1A 3.66513190181895 6.60300917645278e-21 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase -0.108479527294966 0.00188268400827089 NA NA NA hsa-miR-505-5p CDKN1A 1.89243395287645 9.82003586561819e-12 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;MirTarget -0.197864415222474 3.15355511624094e-05 NA NA NA hsa-miR-93-5p CDKN1A 3.03961860136032 1.11672209617395e-24 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.230725362813635 6.59990926283075e-08 25633810 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC liver cancer hsa-miR-942-5p CDKN1A 2.35195531153712 5.45059325728841e-16 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate -0.260648356679274 4.62199208083779e-09 NA NA NA hsa-miR-96-5p CDKN1A 4.89433085814374 1.92000659886961e-31 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase -0.131322885353092 1.73810674264337e-05 26582573 Upregulation of microRNA 96 and its oncogenic functions by targeting CDKN1A in bladder cancer; Bioinformatics prediction combined with luciferase reporter assay were used to verify whether the cyclin-dependent kinase inhibitor CDKN1A was a potential target gene of miR-96; According to the data of miRTarBase CDKN1A might be a candidate target gene of miR-96; In addition luciferase reporter and Western blot assays respectively demonstrated that miR-96 could bind to the putative seed region in CDKN1A mRNA 3'UTR and significantly reduce the expression level of CDKN1A protein; Moreover we found that the inhibition of miR-96 expression remarkably decreased cell proliferation and promoted cell apoptosis of BC cell lines which was consistent with the findings observed following the introduction of CDKN1A cDNA without 3'UTR restored miR-96; Upregulation of miR-96 may contribute to aggressive malignancy partly through suppressing CDKN1A protein expression in BC cells bladder cancer hsa-miR-98-5p CDKN1A 1.11154309866014 1.24143909012085e-08 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;MirTarget -0.251133283878821 0.000264648620156197 NA NA NA hsa-miR-221-3p CDKN1B 0.451556679024397 0.0909808299917811 0.111589542072177 0.453851218822883 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.108173416521144 5.5134677794152e-05 23637992;19953484;23939688;19126397;20146005;23967190;17569667;22992757;17721077;20461750 miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression progression;;;;staging;tumorigenesis;;;;;poor survival breast cancer;glioblastoma;breast cancer;melanoma;liver cancer;pancreatic cancer;prostate cancer;breast cancer;glioblastoma;ovarian cancer hsa-miR-24-3p CDKN1B 0.99989036772428 1.35595013650376e-07 0.111589542072177 0.453851218822883 miRNAWalker2_validate;miRNATAP -0.155773035071718 3.27990988982606e-05 26847530;26044523 The biological significance of miR-24 expression in prostate cancer cells was assessed by a series of in vitro bioassays and the effect on proposed targets p27 CDKN1B and p16 CDK2NA was investigated;With the bioinformatic method we further identified that p27Kip1 is a direct target of miR-24-3p and its protein level was negatively regulated by miR-24-3p ; prostate cancer;breast cancer hsa-miR-199a-3p CHAD 0.640600337515787 0.0380326905134914 0.90626421149234 0.0316978890244433 MirTarget;miRNATAP -0.167396471586919 0.011569180141807 NA NA NA hsa-miR-199b-3p CHAD 0.643923492750702 0.0371742251925406 0.90626421149234 0.0316978890244433 MirTarget -0.167102518581813 0.0116570148913042 NA NA NA hsa-miR-221-5p CHAD -0.745357436702497 0.081887809839391 0.90626421149234 0.0316978890244433 MirTarget -0.271739701886949 1.54053935704285e-08 NA NA NA hsa-miR-222-5p CHAD 1.25632771414778 0.000138653440511922 0.90626421149234 0.0316978890244433 MirTarget -0.297028268506026 1.1416453645667e-06 NA NA NA hsa-miR-10b-3p CHRM2 0.77597971642517 0.00264877454133753 -5.86102306490033 2.38587396341708e-19 mirMAP -0.95799436911561 1.18929937865421e-14 NA NA NA hsa-miR-126-5p CHRM2 0.895338176458417 2.33372756450713e-05 -5.86102306490033 2.38587396341708e-19 mirMAP -0.987677012550827 1.03720880501528e-10 NA NA NA hsa-miR-129-5p CHRM2 -0.524170159980738 0.222582956006346 -5.86102306490033 2.38587396341708e-19 miRanda;mirMAP -0.17366239049114 0.0268622224775902 NA NA NA hsa-miR-142-5p CHRM2 1.17581605694506 0.0018174701991234 -5.86102306490033 2.38587396341708e-19 mirMAP -0.295184774893508 0.000688671207344128 NA NA NA hsa-miR-16-1-3p CHRM2 2.56983217111073 3.02262181237943e-20 -5.86102306490033 2.38587396341708e-19 mirMAP -1.17166455150929 8.96082494881957e-27 NA NA NA hsa-miR-17-5p CHRM2 3.2710598467455 9.93128340539455e-27 -5.86102306490033 2.38587396341708e-19 TargetScan -1.19387640823933 5.43424784848094e-38 NA NA NA hsa-miR-186-5p CHRM2 1.47445398888668 3.0781726595413e-15 -5.86102306490033 2.38587396341708e-19 mirMAP -1.75308201090879 2.82070182528561e-27 NA NA NA hsa-miR-26a-2-3p CHRM2 0.823520019989974 0.00017092160823769 -5.86102306490033 2.38587396341708e-19 mirMAP -0.672638984537191 8.05224171465402e-06 NA NA NA hsa-miR-29b-1-5p CHRM2 1.55384379072167 4.76870585070176e-05 -5.86102306490033 2.38587396341708e-19 mirMAP -0.68158242381208 1.09766268517074e-14 NA NA NA hsa-miR-3065-5p CHRM2 2.74629919868982 1.86846589298284e-08 -5.86102306490033 2.38587396341708e-19 mirMAP -0.467512958220787 5.51189093875011e-09 NA NA NA hsa-miR-335-3p CHRM2 3.08791651139852 5.31309869723517e-12 -5.86102306490033 2.38587396341708e-19 mirMAP -0.428175756335501 1.25598702121735e-09 NA NA NA hsa-miR-335-5p CHRM2 1.77247705492746 2.22457658872091e-06 -5.86102306490033 2.38587396341708e-19 miRNAWalker2_validate -0.397830485181734 4.14110958873843e-06 NA NA NA hsa-miR-429 CHRM2 4.48815175680773 2.44117492218206e-17 -5.86102306490033 2.38587396341708e-19 miRanda -0.443399143794125 2.04489581110554e-14 NA NA NA hsa-miR-501-5p CHRM2 1.93654809410041 1.3779381780759e-10 -5.86102306490033 2.38587396341708e-19 mirMAP -0.715863676474652 3.53920524163862e-11 NA NA NA hsa-miR-542-3p CHRM2 1.18832665895751 1.98700670691565e-07 -5.86102306490033 2.38587396341708e-19 miRanda -0.448438712806453 0.00174095011085772 NA NA NA hsa-miR-590-3p CHRM2 2.59289455139753 1.03200520972022e-21 -5.86102306490033 2.38587396341708e-19 mirMAP -1.283531507016 6.4412941339435e-31 NA NA NA hsa-miR-664a-3p CHRM2 0.634721925861133 0.00520070178640421 -5.86102306490033 2.38587396341708e-19 mirMAP -0.493764289140327 0.000695534327790569 NA NA NA hsa-miR-708-3p CHRM2 2.80907765282502 3.07460722669281e-14 -5.86102306490033 2.38587396341708e-19 mirMAP -0.468471767054915 3.97330458972302e-08 NA NA NA hsa-miR-29b-2-5p CHUK 0.910668640983475 0.00666655585493488 -0.123960303858583 0.302722046952969 MirTarget -0.105463511044412 4.36313837727314e-10 NA NA NA hsa-miR-497-5p CHUK 0.0257087130056286 0.918145413833358 -0.123960303858583 0.302722046952969 MirTarget -0.130303574602807 1.33264117705817e-08 NA NA NA hsa-let-7a-5p COL1A1 0.618599506841644 2.76973453058748e-05 -0.110889675073027 0.820072046630299 TargetScan;miRNATAP -0.975861159435873 8.61416320768625e-10 NA NA NA hsa-let-7b-5p COL1A1 0.604314269683977 0.00140009936153214 -0.110889675073027 0.820072046630299 miRNATAP -0.443124127266192 0.000399485996123428 NA NA NA hsa-let-7d-5p COL1A1 1.33236798905207 1.1741085658466e-13 -0.110889675073027 0.820072046630299 miRNATAP -0.81867235251875 9.37375814517517e-11 NA NA NA hsa-let-7e-5p COL1A1 0.860104282510173 6.04758298373779e-05 -0.110889675073027 0.820072046630299 miRNATAP -0.347601997285448 0.0015429941878112 NA NA NA hsa-let-7f-5p COL1A1 0.495648727272215 0.00355972741198794 -0.110889675073027 0.820072046630299 miRNATAP -0.637858159816604 4.63118529376979e-06 NA NA NA hsa-let-7g-5p COL1A1 1.20061455355116 1.50237505511483e-12 -0.110889675073027 0.820072046630299 miRNATAP -1.09424520257645 1.39176730688231e-16 NA NA NA hsa-miR-106a-5p COL1A1 2.48882002962836 1.99757727374521e-12 -0.110889675073027 0.820072046630299 mirMAP -0.435796609970468 5.9115479947617e-12 NA NA NA hsa-miR-106b-5p COL1A1 2.46782146831112 1.36171495805632e-23 -0.110889675073027 0.820072046630299 mirMAP -0.785038282718627 1.75260912749901e-19 NA NA NA hsa-miR-107 COL1A1 1.30977326593435 1.30372468603965e-11 -0.110889675073027 0.820072046630299 PITA;miRanda -0.871419734903876 8.19788155995674e-14 NA NA NA hsa-miR-126-5p COL1A1 0.895338176458417 2.33372756450713e-05 -0.110889675073027 0.820072046630299 miRNATAP -0.352823579048176 0.00150028497759076 NA NA NA hsa-miR-129-5p COL1A1 -0.524170159980738 0.222582956006346 -0.110889675073027 0.820072046630299 miRanda -0.284256940870227 2.72380215920999e-07 NA NA NA hsa-miR-17-5p COL1A1 3.2710598467455 9.93128340539455e-27 -0.110889675073027 0.820072046630299 mirMAP -0.475867326069058 1.83511456036068e-11 NA NA NA hsa-miR-196b-5p COL1A1 1.71646270856386 4.37735885910369e-09 -0.110889675073027 0.820072046630299 miRNATAP -0.373453069766994 2.00605578472263e-06 NA NA NA hsa-miR-20a-5p COL1A1 3.15577933619191 4.19753346442454e-25 -0.110889675073027 0.820072046630299 mirMAP -0.494301670347482 3.77198661227248e-12 NA NA NA hsa-miR-20b-5p COL1A1 2.07706563022469 1.10107236083433e-05 -0.110889675073027 0.820072046630299 mirMAP -0.339124004325201 1.77359442908345e-12 NA NA NA hsa-miR-23a-5p COL1A1 1.46491071577368 0.000241866585858992 -0.110889675073027 0.820072046630299 mirMAP -0.202895794574221 0.00113612726669324 NA NA NA hsa-miR-29b-3p COL1A1 1.65828197923813 1.02676780888141e-09 -0.110889675073027 0.820072046630299 miRNAWalker2_validate;miRTarBase;miRNATAP -0.346531814240984 4.42322074969025e-05 NA NA NA hsa-miR-29c-3p COL1A1 -0.00968972577705429 0.97099586346872 -0.110889675073027 0.820072046630299 miRNAWalker2_validate;miRTarBase;miRNATAP -0.606234586064105 2.82202311553993e-12 NA NA NA hsa-miR-30b-3p COL1A1 0.834142820354026 0.000972582820878813 -0.110889675073027 0.820072046630299 miRNATAP -0.752938614458806 7.53780750895872e-17 NA NA NA hsa-miR-30d-3p COL1A1 0.977747550180601 4.3048212205381e-05 -0.110889675073027 0.820072046630299 mirMAP -0.876999502564275 1.06999478894224e-20 NA NA NA hsa-miR-30e-3p COL1A1 -0.215663037684509 0.235375122783546 -0.110889675073027 0.820072046630299 mirMAP -1.08848274131506 7.81072243881094e-18 NA NA NA hsa-miR-330-3p COL1A1 0.876747334239085 0.00073709016089703 -0.110889675073027 0.820072046630299 mirMAP -0.674963970631739 1.66749586425468e-14 NA NA NA hsa-miR-361-3p COL1A1 1.07367425434318 1.73142774168958e-09 -0.110889675073027 0.820072046630299 PITA -0.313792618632358 0.0170438146372981 NA NA NA hsa-miR-532-3p COL1A1 1.96631878320218 4.53421954361695e-13 -0.110889675073027 0.820072046630299 PITA;miRNATAP -0.457284092613172 4.2404603042954e-08 NA NA NA hsa-miR-590-3p COL1A1 2.59289455139753 1.03200520972022e-21 -0.110889675073027 0.820072046630299 miRanda -0.409879883063743 1.19715990382964e-06 NA NA NA hsa-miR-625-5p COL1A1 1.42540152147292 1.95797147911206e-06 -0.110889675073027 0.820072046630299 MirTarget -0.295282834517255 0.000543029878293581 NA NA NA hsa-miR-92a-1-5p COL1A1 2.23721820014467 5.12925824784972e-09 -0.110889675073027 0.820072046630299 MirTarget -0.519499753869149 3.68969567887779e-15 NA NA NA hsa-miR-93-5p COL1A1 3.03961860136032 1.11672209617395e-24 -0.110889675073027 0.820072046630299 mirMAP -0.631011490658207 2.16984785580252e-18 NA NA NA hsa-miR-944 COL1A1 2.91186649218281 1.31574753528144e-06 -0.110889675073027 0.820072046630299 PITA;miRNATAP -0.24972943878016 1.67238457219526e-10 NA NA NA hsa-let-7a-3p COL1A2 1.42015538786275 7.03375209382654e-13 -0.907878215431927 0.0536183978525595 MirTarget -0.34337905867058 0.00237172044988904 NA NA NA hsa-let-7a-5p COL1A2 0.618599506841644 2.76973453058748e-05 -0.907878215431927 0.0536183978525595 MirTarget;TargetScan;miRNATAP -1.0007378445628 6.8905642974555e-11 NA NA NA hsa-let-7b-5p COL1A2 0.604314269683977 0.00140009936153214 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.478444481642473 7.47972175420684e-05 NA NA NA hsa-let-7d-5p COL1A2 1.33236798905207 1.1741085658466e-13 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.833365154358605 8.07853763796414e-12 NA NA NA hsa-let-7e-5p COL1A2 0.860104282510173 6.04758298373779e-05 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.319588066942386 0.00262155508152948 NA NA NA hsa-let-7f-5p COL1A2 0.495648727272215 0.00355972741198794 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.633957491871988 2.457417468533e-06 NA NA NA hsa-let-7g-5p COL1A2 1.20061455355116 1.50237505511483e-12 -0.907878215431927 0.0536183978525595 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -1.10610568731162 4.13919461130197e-18 NA NA NA hsa-miR-125a-5p COL1A2 0.599529391575274 0.0102300147180307 -0.907878215431927 0.0536183978525595 miRanda -0.319937796765224 0.00107219463707015 NA NA NA hsa-miR-129-5p COL1A2 -0.524170159980738 0.222582956006346 -0.907878215431927 0.0536183978525595 miRanda -0.229642206791278 1.9113276997333e-05 NA NA NA hsa-miR-196b-5p COL1A2 1.71646270856386 4.37735885910369e-09 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.41200934343234 5.17914353904317e-08 NA NA NA hsa-miR-19a-3p COL1A2 3.42309334186656 3.02671914353412e-28 -0.907878215431927 0.0536183978525595 MirTarget -0.413334735466662 8.74675301182705e-10 NA NA NA hsa-miR-19b-3p COL1A2 2.49529833021187 1.57028265846699e-23 -0.907878215431927 0.0536183978525595 MirTarget -0.615768487699155 2.9812496765956e-13 NA NA NA hsa-miR-25-3p COL1A2 1.36472605225697 4.83790725935681e-11 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.714969163443613 1.39606547277116e-11 NA NA NA hsa-miR-26b-5p COL1A2 0.885393662798425 3.2116297961629e-06 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.600394268231924 4.19125369291339e-07 NA NA NA hsa-miR-29b-3p COL1A2 1.65828197923813 1.02676780888141e-09 -0.907878215431927 0.0536183978525595 miRNATAP -0.37551592391965 4.46023473383405e-06 NA NA NA hsa-miR-29c-3p COL1A2 -0.00968972577705429 0.97099586346872 -0.907878215431927 0.0536183978525595 miRNAWalker2_validate;miRTarBase;miRNATAP -0.552726028389517 5.19310800999508e-11 NA NA NA hsa-miR-30d-3p COL1A2 0.977747550180601 4.3048212205381e-05 -0.907878215431927 0.0536183978525595 MirTarget -0.853220165900042 5.87791108055389e-21 NA NA NA hsa-miR-30e-3p COL1A2 -0.215663037684509 0.235375122783546 -0.907878215431927 0.0536183978525595 MirTarget -0.90580927081412 2.55621171763522e-13 NA NA NA hsa-miR-32-3p COL1A2 2.02436999565685 5.94091197945307e-09 -0.907878215431927 0.0536183978525595 miRNATAP -0.536353098180589 5.67801057528553e-14 NA NA NA hsa-miR-32-5p COL1A2 2.34056473219422 6.24134585974322e-20 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.48256717723832 9.18871844795078e-09 NA NA NA hsa-miR-330-5p COL1A2 1.15100069700871 4.85551805046014e-07 -0.907878215431927 0.0536183978525595 miRanda -0.496611927247797 3.93209191587865e-07 NA NA NA hsa-miR-33a-3p COL1A2 1.72765312072219 1.51784443453521e-07 -0.907878215431927 0.0536183978525595 MirTarget -0.679993547467201 2.17692389592669e-21 NA NA NA hsa-miR-363-3p COL1A2 1.50575300026701 0.00020976164678918 -0.907878215431927 0.0536183978525595 MirTarget -0.353877286078259 9.32755334167874e-11 NA NA NA hsa-miR-590-3p COL1A2 2.59289455139753 1.03200520972022e-21 -0.907878215431927 0.0536183978525595 miRanda -0.440962251043098 5.92080348086989e-08 NA NA NA hsa-miR-7-1-3p COL1A2 1.84950311431067 1.25300363397654e-13 -0.907878215431927 0.0536183978525595 mirMAP -0.450201118044729 3.14014784977594e-07 NA NA NA hsa-miR-92a-3p COL1A2 2.06460102658973 1.44784291084757e-19 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.833093472607066 1.25536202925879e-19 NA NA NA hsa-miR-98-5p COL1A2 1.11154309866014 1.24143909012085e-08 -0.907878215431927 0.0536183978525595 MirTarget -0.757659815957651 2.42759440753309e-11 NA NA NA hsa-miR-29c-3p COL2A1 -0.00968972577705429 0.97099586346872 2.18594271809993 0.000327509354583268 MirTarget;miRNATAP -0.463807419886591 3.01562700961379e-05 NA NA NA hsa-let-7a-3p COL4A1 1.42015538786275 7.03375209382654e-13 0.151465916664922 0.581694470985045 miRNATAP -0.207862002239419 0.00158784209627186 NA NA NA hsa-let-7a-5p COL4A1 0.618599506841644 2.76973453058748e-05 0.151465916664922 0.581694470985045 TargetScan;miRNATAP -0.442098228023527 1.00399459970798e-06 NA NA NA hsa-let-7b-5p COL4A1 0.604314269683977 0.00140009936153214 0.151465916664922 0.581694470985045 miRNATAP -0.260987692213768 0.00021341519200331 NA NA NA hsa-let-7f-5p COL4A1 0.495648727272215 0.00355972741198794 0.151465916664922 0.581694470985045 miRNATAP -0.294689845868312 0.000184159897657789 NA NA NA hsa-let-7g-5p COL4A1 1.20061455355116 1.50237505511483e-12 0.151465916664922 0.581694470985045 miRNATAP -0.457888848569706 1.70166576381862e-09 NA NA NA hsa-miR-125a-5p COL4A1 0.599529391575274 0.0102300147180307 0.151465916664922 0.581694470985045 miRNAWalker2_validate;miRanda -0.196409517018995 0.000565233811607909 NA NA NA hsa-miR-148a-3p COL4A1 1.26728238710376 2.52325607402829e-06 0.151465916664922 0.581694470985045 miRNATAP -0.227396815859122 2.77390532352486e-06 NA NA NA hsa-miR-16-5p COL4A1 1.75824877145857 1.68592440033108e-16 0.151465916664922 0.581694470985045 miRNAWalker2_validate -0.273095281738351 5.23183239600475e-06 NA NA NA hsa-miR-17-5p COL4A1 3.2710598467455 9.93128340539455e-27 0.151465916664922 0.581694470985045 TargetScan -0.190337705152129 2.54377799768868e-06 NA NA NA hsa-miR-205-5p COL4A1 4.1389800495524 2.05488295686453e-12 0.151465916664922 0.581694470985045 miRNATAP -0.148667493224682 3.51597977558842e-12 NA NA NA hsa-miR-29b-3p COL4A1 1.65828197923813 1.02676780888141e-09 0.151465916664922 0.581694470985045 miRNAWalker2_validate;miRTarBase;miRNATAP -0.260273590677078 4.10687060161825e-08 NA NA NA hsa-miR-29c-3p COL4A1 -0.00968972577705429 0.97099586346872 0.151465916664922 0.581694470985045 miRNAWalker2_validate;miRTarBase;miRNATAP -0.273632347235992 3.08821831062353e-08 NA NA NA hsa-miR-3065-5p COL4A1 2.74629919868982 1.86846589298284e-08 0.151465916664922 0.581694470985045 miRNATAP -0.11834270493481 0.000288906172625696 NA NA NA hsa-miR-320a COL4A1 0.438165828017084 0.0390159073347133 0.151465916664922 0.581694470985045 miRanda -0.292390284980215 2.90823813846283e-06 NA NA NA hsa-miR-320b COL4A1 1.55692969039548 1.41071034251915e-08 0.151465916664922 0.581694470985045 miRanda -0.225426369231117 1.86319037296535e-06 NA NA NA hsa-miR-330-5p COL4A1 1.15100069700871 4.85551805046014e-07 0.151465916664922 0.581694470985045 miRanda -0.163276523355723 0.00463020888504854 NA NA NA hsa-miR-362-3p COL4A1 2.0756816987665 3.89026064579331e-12 0.151465916664922 0.581694470985045 miRanda -0.117789768617334 0.00857528731771554 NA NA NA hsa-miR-429 COL4A1 4.48815175680773 2.44117492218206e-17 0.151465916664922 0.581694470985045 miRanda;miRNATAP -0.170995787476466 2.64041159335847e-13 NA NA NA hsa-miR-590-3p COL4A1 2.59289455139753 1.03200520972022e-21 0.151465916664922 0.581694470985045 miRanda -0.196848804346619 3.75186434917263e-05 NA NA NA hsa-miR-590-5p COL4A1 3.18300989862077 2.06813568597893e-26 0.151465916664922 0.581694470985045 miRanda;miRNATAP -0.183813053545641 1.58532123855151e-05 NA NA NA hsa-miR-769-3p COL4A1 2.19896922202687 5.69250370895053e-12 0.151465916664922 0.581694470985045 miRNAWalker2_validate -0.208132027501523 4.98704429599058e-07 NA NA NA hsa-miR-92a-3p COL4A1 2.06460102658973 1.44784291084757e-19 0.151465916664922 0.581694470985045 miRNAWalker2_validate -0.290767640334324 1.44691249323084e-07 NA NA NA hsa-let-7a-5p COL4A2 0.618599506841644 2.76973453058748e-05 -0.27910991086701 0.308355154850744 TargetScan;miRNATAP -0.555056049505749 5.22435747579625e-10 NA NA NA hsa-let-7b-5p COL4A2 0.604314269683977 0.00140009936153214 -0.27910991086701 0.308355154850744 miRNATAP -0.315567704720702 6.54540039466691e-06 NA NA NA hsa-let-7e-5p COL4A2 0.860104282510173 6.04758298373779e-05 -0.27910991086701 0.308355154850744 miRNATAP -0.159408726979961 0.00989974004128267 NA NA NA hsa-let-7f-5p COL4A2 0.495648727272215 0.00355972741198794 -0.27910991086701 0.308355154850744 miRNATAP -0.365132449467995 3.02342955523422e-06 NA NA NA hsa-let-7g-5p COL4A2 1.20061455355116 1.50237505511483e-12 -0.27910991086701 0.308355154850744 miRNATAP -0.557185574693694 1.0518017366577e-13 NA NA NA hsa-miR-10a-5p COL4A2 1.15016989191194 0.00372037233992369 -0.27910991086701 0.308355154850744 miRNAWalker2_validate -0.171332545245499 1.86859577879628e-07 NA NA NA hsa-miR-1266-5p COL4A2 1.3763848124288 0.000876906064212958 -0.27910991086701 0.308355154850744 MirTarget -0.190223128284874 1.49525127120344e-09 NA NA NA hsa-miR-16-5p COL4A2 1.75824877145857 1.68592440033108e-16 -0.27910991086701 0.308355154850744 miRNAWalker2_validate -0.378894147531602 1.40485603477633e-10 NA NA NA hsa-miR-26b-5p COL4A2 0.885393662798425 3.2116297961629e-06 -0.27910991086701 0.308355154850744 miRNAWalker2_validate -0.419978526666598 8.53353167401164e-10 NA NA NA hsa-miR-29b-3p COL4A2 1.65828197923813 1.02676780888141e-09 -0.27910991086701 0.308355154850744 miRTarBase;MirTarget;miRNATAP -0.246645870557632 1.93495146133022e-07 NA NA NA hsa-miR-29c-3p COL4A2 -0.00968972577705429 0.97099586346872 -0.27910991086701 0.308355154850744 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.268164535791781 5.36677401020056e-08 NA NA NA hsa-miR-92a-3p COL4A2 2.06460102658973 1.44784291084757e-19 -0.27910991086701 0.308355154850744 miRNAWalker2_validate -0.366419003795853 1.87188534268414e-11 NA NA NA hsa-miR-106b-5p COL4A3 2.46782146831112 1.36171495805632e-23 -3.13816823718198 5.72507717181151e-07 MirTarget;miRNATAP -0.356079757521708 0.0026595219634943 NA NA NA hsa-miR-135b-5p COL4A3 3.62510365056501 1.09148980810091e-10 -3.13816823718198 5.72507717181151e-07 MirTarget -0.455268481160993 8.46740685628871e-17 NA NA NA hsa-miR-15b-3p COL4A3 2.33847028227712 4.29662877950836e-19 -3.13816823718198 5.72507717181151e-07 mirMAP -0.598465501362876 7.8680213396769e-08 NA NA NA hsa-miR-16-2-3p COL4A3 2.31623086727196 4.29838149388188e-20 -3.13816823718198 5.72507717181151e-07 mirMAP -0.540347771599333 3.14860125745273e-06 NA NA NA hsa-miR-17-5p COL4A3 3.2710598467455 9.93128340539455e-27 -3.13816823718198 5.72507717181151e-07 MirTarget;TargetScan;miRNATAP -0.295183382551472 0.00178229473839054 NA NA NA hsa-miR-200b-3p COL4A3 3.78235093249346 3.18343003239465e-14 -3.13816823718198 5.72507717181151e-07 TargetScan -0.192462389252058 0.00124547288244068 NA NA NA hsa-miR-200c-3p COL4A3 3.50132673580082 2.42716349086937e-15 -3.13816823718198 5.72507717181151e-07 miRNATAP -0.321328173209356 1.3577907991277e-06 NA NA NA hsa-miR-20a-5p COL4A3 3.15577933619191 4.19753346442454e-25 -3.13816823718198 5.72507717181151e-07 MirTarget;miRNATAP -0.278469612238524 0.00343421936429172 NA NA NA hsa-miR-26b-5p COL4A3 0.885393662798425 3.2116297961629e-06 -3.13816823718198 5.72507717181151e-07 mirMAP -0.517410941720943 0.00138213365907858 NA NA NA hsa-miR-330-3p COL4A3 0.876747334239085 0.00073709016089703 -3.13816823718198 5.72507717181151e-07 miRNATAP -0.34818501224001 0.00325935588427848 NA NA NA hsa-miR-330-5p COL4A3 1.15100069700871 4.85551805046014e-07 -3.13816823718198 5.72507717181151e-07 miRanda -0.32580916134497 0.0149193915101007 NA NA NA hsa-miR-335-3p COL4A3 3.08791651139852 5.31309869723517e-12 -3.13816823718198 5.72507717181151e-07 mirMAP -0.212748527192813 0.00144411963809827 NA NA NA hsa-miR-33a-3p COL4A3 1.72765312072219 1.51784443453521e-07 -3.13816823718198 5.72507717181151e-07 MirTarget -0.238700429390567 0.0188455147610857 NA NA NA hsa-miR-3607-3p COL4A3 2.68532138541128 5.66716351955047e-14 -3.13816823718198 5.72507717181151e-07 miRNATAP -0.264323169239836 0.0020449760665079 NA NA NA hsa-miR-429 COL4A3 4.48815175680773 2.44117492218206e-17 -3.13816823718198 5.72507717181151e-07 miRanda;miRNATAP -0.185704892847223 0.000833713303752716 NA NA NA hsa-miR-590-3p COL4A3 2.59289455139753 1.03200520972022e-21 -3.13816823718198 5.72507717181151e-07 miRanda -0.346569574891081 0.00182604733860441 NA NA NA hsa-miR-625-5p COL4A3 1.42540152147292 1.95797147911206e-06 -3.13816823718198 5.72507717181151e-07 MirTarget -0.300058388991048 0.00730909697791081 NA NA NA hsa-miR-7-1-3p COL4A3 1.84950311431067 1.25300363397654e-13 -3.13816823718198 5.72507717181151e-07 MirTarget -0.418100740890283 0.000488782979662804 NA NA NA hsa-miR-93-3p COL4A3 2.85383869771942 5.64481766902125e-23 -3.13816823718198 5.72507717181151e-07 miRNATAP -0.350961495481548 0.00049589977153136 NA NA NA hsa-miR-93-5p COL4A3 3.03961860136032 1.11672209617395e-24 -3.13816823718198 5.72507717181151e-07 MirTarget;miRNATAP -0.296178866008216 0.00251395375272297 NA NA NA hsa-miR-944 COL4A3 2.91186649218281 1.31574753528144e-06 -3.13816823718198 5.72507717181151e-07 mirMAP -0.470082229895092 2.85085625954113e-21 NA NA NA hsa-let-7a-3p COL4A4 1.42015538786275 7.03375209382654e-13 -2.67173783661591 1.38931523312633e-08 mirMAP -0.72624691842757 1.21978218154155e-10 NA NA NA hsa-let-7b-3p COL4A4 0.868207752019623 1.30460056774366e-05 -2.67173783661591 1.38931523312633e-08 mirMAP -0.598092410640755 2.08347545315856e-07 NA NA NA hsa-let-7f-1-3p COL4A4 1.55054488387679 7.31326775537952e-11 -2.67173783661591 1.38931523312633e-08 mirMAP -0.384051437325553 8.99794956451272e-05 NA NA NA hsa-miR-107 COL4A4 1.30977326593435 1.30372468603965e-11 -2.67173783661591 1.38931523312633e-08 miRanda -0.444871076460779 0.000156290753181754 NA NA NA hsa-miR-125a-3p COL4A4 1.24490295132072 5.26925231010328e-06 -2.67173783661591 1.38931523312633e-08 miRanda -0.25826775995058 0.00216559072274224 NA NA NA hsa-miR-130b-3p COL4A4 3.5350292994509 1.73934183852569e-27 -2.67173783661591 1.38931523312633e-08 mirMAP -0.440966693862841 1.42117813907464e-11 NA NA NA hsa-miR-15b-3p COL4A4 2.33847028227712 4.29662877950836e-19 -2.67173783661591 1.38931523312633e-08 MirTarget -0.593481114193173 7.85751722124751e-13 NA NA NA hsa-miR-16-5p COL4A4 1.75824877145857 1.68592440033108e-16 -2.67173783661591 1.38931523312633e-08 mirMAP -0.635762257215767 8.60168648267243e-10 NA NA NA hsa-miR-181a-2-3p COL4A4 2.19062681262366 3.81790102612782e-13 -2.67173783661591 1.38931523312633e-08 MirTarget -0.422865160639886 9.57070978697212e-09 NA NA NA hsa-miR-182-5p COL4A4 3.53923166221814 5.07781258121574e-21 -2.67173783661591 1.38931523312633e-08 MirTarget -0.362520040793316 2.96679913995388e-10 NA NA NA hsa-miR-186-5p COL4A4 1.47445398888668 3.0781726595413e-15 -2.67173783661591 1.38931523312633e-08 mirMAP -0.451905914888237 0.000183162247591296 NA NA NA hsa-miR-203a-3p COL4A4 3.12352008343999 9.49391438647189e-07 -2.67173783661591 1.38931523312633e-08 MirTarget -0.238846206212514 9.09285953468299e-12 NA NA NA hsa-miR-2110 COL4A4 1.16625590651194 6.4784195289885e-05 -2.67173783661591 1.38931523312633e-08 miRNATAP -0.21389605467473 0.0118517639296358 NA NA NA hsa-miR-224-3p COL4A4 1.87536386559317 6.15140969394846e-05 -2.67173783661591 1.38931523312633e-08 mirMAP -0.241016146627441 2.26603163932463e-06 NA NA NA hsa-miR-23a-3p COL4A4 1.00493340843378 2.55313889288924e-08 -2.67173783661591 1.38931523312633e-08 miRNATAP -0.97309775128809 4.56001638110102e-15 NA NA NA hsa-miR-26b-5p COL4A4 0.885393662798425 3.2116297961629e-06 -2.67173783661591 1.38931523312633e-08 miRNAWalker2_validate -0.557345439674537 4.15131416507081e-06 NA NA NA hsa-miR-29b-3p COL4A4 1.65828197923813 1.02676780888141e-09 -2.67173783661591 1.38931523312633e-08 MirTarget;miRNATAP -0.257961637914997 0.00209565988601788 NA NA NA hsa-miR-301a-3p COL4A4 2.81024345929638 2.29784847962242e-17 -2.67173783661591 1.38931523312633e-08 mirMAP -0.396739245825735 1.52463061349103e-08 NA NA NA hsa-miR-30d-3p COL4A4 0.977747550180601 4.3048212205381e-05 -2.67173783661591 1.38931523312633e-08 MirTarget -0.29356253314235 0.00242399072433168 NA NA NA hsa-miR-33a-3p COL4A4 1.72765312072219 1.51784443453521e-07 -2.67173783661591 1.38931523312633e-08 mirMAP -0.299110687922727 8.48873920473041e-05 NA NA NA hsa-miR-34c-3p COL4A4 2.41359195938096 3.46966584087088e-10 -2.67173783661591 1.38931523312633e-08 mirMAP -0.249162835878457 4.24334888375137e-05 NA NA NA hsa-miR-34c-5p COL4A4 2.07190852984647 7.35776320806257e-08 -2.67173783661591 1.38931523312633e-08 miRanda -0.232565975966568 0.000227102927882777 NA NA NA hsa-miR-361-5p COL4A4 0.971859117235239 5.30236555707088e-09 -2.67173783661591 1.38931523312633e-08 MirTarget;miRanda -0.601945019657765 1.30840602125945e-05 NA NA NA hsa-miR-429 COL4A4 4.48815175680773 2.44117492218206e-17 -2.67173783661591 1.38931523312633e-08 miRNATAP -0.235316763623681 1.25652486579793e-08 NA NA NA hsa-miR-454-3p COL4A4 2.47234127820054 1.12878018736016e-21 -2.67173783661591 1.38931523312633e-08 mirMAP -0.44110156791909 3.96857482917649e-07 NA NA NA hsa-miR-501-5p COL4A4 1.93654809410041 1.3779381780759e-10 -2.67173783661591 1.38931523312633e-08 mirMAP -0.234783512217726 0.00244437462470149 NA NA NA hsa-miR-532-3p COL4A4 1.96631878320218 4.53421954361695e-13 -2.67173783661591 1.38931523312633e-08 miRNATAP -0.357025453490349 1.56638435736529e-05 NA NA NA hsa-miR-576-5p COL4A4 2.20467023993664 3.4053475193793e-19 -2.67173783661591 1.38931523312633e-08 PITA -0.544520280305921 9.10111712753134e-10 NA NA NA hsa-miR-589-3p COL4A4 2.51971841868825 2.39125940264107e-11 -2.67173783661591 1.38931523312633e-08 mirMAP -0.260991358417465 0.000125734648959878 NA NA NA hsa-miR-590-3p COL4A4 2.59289455139753 1.03200520972022e-21 -2.67173783661591 1.38931523312633e-08 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.469855203417434 1.30222165601332e-08 NA NA NA hsa-miR-629-3p COL4A4 2.36570947321815 1.33458201201618e-11 -2.67173783661591 1.38931523312633e-08 MirTarget;miRNATAP -0.409756216232473 1.35574037997148e-08 NA NA NA hsa-miR-944 COL4A4 2.91186649218281 1.31574753528144e-06 -2.67173783661591 1.38931523312633e-08 PITA;mirMAP;miRNATAP -0.389806097027732 4.8995573962282e-26 NA NA NA hsa-let-7g-5p COL4A5 1.20061455355116 1.50237505511483e-12 -1.24599871794839 0.00136543123614109 miRNATAP -0.307164450152846 0.00527890047083946 NA NA NA hsa-let-7i-5p COL4A5 0.412877696970403 0.00622731051981756 -1.24599871794839 0.00136543123614109 miRNATAP -0.64796467771581 2.93038764886602e-07 NA NA NA hsa-miR-146b-5p COL4A5 1.75587235896724 1.15724631266659e-07 -1.24599871794839 0.00136543123614109 miRanda -0.293386738176784 1.34320297703579e-07 NA NA NA hsa-miR-193a-3p COL4A5 1.60460546928078 2.86169793322984e-07 -1.24599871794839 0.00136543123614109 miRanda -0.379147371498783 9.59792345740427e-11 NA NA NA hsa-miR-199b-3p COL4A5 0.643923492750702 0.0371742251925406 -1.24599871794839 0.00136543123614109 miRNATAP -0.196611355383528 0.00130673820569446 NA NA NA hsa-miR-338-5p COL4A5 -0.577691606146419 0.0472212680542825 -1.24599871794839 0.00136543123614109 PITA;miRNATAP -0.346125860521558 9.47078293292978e-08 NA NA NA hsa-miR-590-3p COL4A5 2.59289455139753 1.03200520972022e-21 -1.24599871794839 0.00136543123614109 miRanda;mirMAP -0.335794009696284 7.11393079687399e-07 NA NA NA hsa-miR-197-3p COL4A6 1.75733174019505 8.88576793100499e-13 -2.86000294682833 8.37273620398162e-07 miRNAWalker2_validate -0.654832103652115 4.04778714168634e-09 NA NA NA hsa-miR-326 COL4A6 0.715313016136042 0.0610265683213359 -2.86000294682833 8.37273620398162e-07 miRanda -0.428482353854255 6.08458619098456e-09 NA NA NA hsa-miR-342-3p COL4A6 1.49115144672245 1.43879249744621e-07 -2.86000294682833 8.37273620398162e-07 miRanda -0.48884805502412 6.4676784510391e-07 NA NA NA hsa-miR-429 COL4A6 4.48815175680773 2.44117492218206e-17 -2.86000294682833 8.37273620398162e-07 miRanda;miRNATAP -0.171292420502726 0.000858134920060823 NA NA NA hsa-miR-590-3p COL4A6 2.59289455139753 1.03200520972022e-21 -2.86000294682833 8.37273620398162e-07 miRanda -0.565460375775464 2.54437761203123e-08 NA NA NA hsa-miR-96-5p COL4A6 4.89433085814374 1.92000659886961e-31 -2.86000294682833 8.37273620398162e-07 TargetScan -0.27846705536655 1.38871365657908e-05 NA NA NA hsa-let-7e-5p COL6A1 0.860104282510173 6.04758298373779e-05 -1.58125621683137 9.60653511272857e-05 miRNAWalker2_validate -0.399732771627717 1.27817822935221e-05 NA NA NA hsa-miR-1301-3p COL6A1 2.54959518791507 5.26618591274892e-18 -1.58125621683137 9.60653511272857e-05 miRNAWalker2_validate -0.460888994796661 1.98153918971194e-13 NA NA NA hsa-miR-324-5p COL6A1 2.95683728155095 1.32960514360912e-20 -1.58125621683137 9.60653511272857e-05 miRNAWalker2_validate -0.414842126756295 7.30883530269486e-13 NA NA NA hsa-miR-335-5p COL6A1 1.77247705492746 2.22457658872091e-06 -1.58125621683137 9.60653511272857e-05 miRNAWalker2_validate -0.227385708807549 1.13078461194542e-05 NA NA NA hsa-miR-10a-5p COL6A2 1.15016989191194 0.00372037233992369 -2.09678899778735 1.31305008920322e-06 miRNAWalker2_validate -0.474265837714119 1.27096286007502e-20 NA NA NA hsa-miR-10b-5p COL6A2 -0.155951595811628 0.555006386998027 -2.09678899778735 1.31305008920322e-06 miRNAWalker2_validate -0.525392591874696 3.08091744996193e-11 NA NA NA hsa-miR-1226-3p COL6A3 1.38118928579963 0.000205503474787488 -1.49732720873756 0.000705770797494499 MirTarget -0.486063466215814 2.60407868738001e-14 NA NA NA hsa-miR-29b-3p COL6A3 1.65828197923813 1.02676780888141e-09 -1.49732720873756 0.000705770797494499 MirTarget;miRNATAP -0.375611788882487 1.11448080467985e-06 NA NA NA hsa-miR-29c-3p COL6A3 -0.00968972577705429 0.97099586346872 -1.49732720873756 0.000705770797494499 MirTarget;miRNATAP -0.474613761856899 2.75572162873452e-09 NA NA NA hsa-miR-320a COL6A3 0.438165828017084 0.0390159073347133 -1.49732720873756 0.000705770797494499 miRanda -0.778342280150975 3.56471409360412e-15 NA NA NA hsa-miR-320b COL6A3 1.55692969039548 1.41071034251915e-08 -1.49732720873756 0.000705770797494499 miRanda -0.653373966741597 1.26383391262323e-18 NA NA NA hsa-miR-330-3p COL6A3 0.876747334239085 0.00073709016089703 -1.49732720873756 0.000705770797494499 miRNATAP -0.632385715219901 2.95499049604057e-15 NA NA NA hsa-miR-362-3p COL6A3 2.0756816987665 3.89026064579331e-12 -1.49732720873756 0.000705770797494499 miRanda -0.194943888306204 0.00721955815029335 NA NA NA hsa-miR-429 COL6A3 4.48815175680773 2.44117492218206e-17 -1.49732720873756 0.000705770797494499 miRNATAP -0.382525267453802 1.91833135798669e-25 NA NA NA hsa-miR-590-3p COL6A3 2.59289455139753 1.03200520972022e-21 -1.49732720873756 0.000705770797494499 miRanda -0.52809690636908 3.52708257722657e-12 NA NA NA hsa-miR-877-5p COL6A3 2.94916202082736 1.8151927276044e-13 -1.49732720873756 0.000705770797494499 MirTarget;miRNATAP -0.455392334335153 1.14050165872702e-15 NA NA NA hsa-miR-103a-2-5p COL6A6 2.47599305985086 7.933028987326e-11 -0.602255903025299 0.268075030849075 mirMAP -0.314232535081092 3.56209144658843e-05 NA NA NA hsa-miR-186-5p COL6A6 1.47445398888668 3.0781726595413e-15 -0.602255903025299 0.268075030849075 MirTarget -0.509782848499001 0.000199024314179136 NA NA NA hsa-miR-30e-3p COL6A6 -0.215663037684509 0.235375122783546 -0.602255903025299 0.268075030849075 mirMAP -0.721700577274424 6.87040566475952e-07 NA NA NA hsa-miR-429 COL6A6 4.48815175680773 2.44117492218206e-17 -0.602255903025299 0.268075030849075 miRanda -0.28781016141925 7.4089341920866e-10 NA NA NA hsa-miR-486-5p COL6A6 -0.194913133034028 0.607377798807705 -0.602255903025299 0.268075030849075 miRanda;miRNATAP -0.25882420958577 0.000181642173336269 NA NA NA hsa-miR-501-5p COL6A6 1.93654809410041 1.3779381780759e-10 -0.602255903025299 0.268075030849075 mirMAP -0.199787467260024 0.0233450350822026 NA NA NA hsa-miR-532-3p COL6A6 1.96631878320218 4.53421954361695e-13 -0.602255903025299 0.268075030849075 MirTarget -0.320887217956997 0.000654121982066416 NA NA NA hsa-miR-576-5p COL6A6 2.20467023993664 3.4053475193793e-19 -0.602255903025299 0.268075030849075 mirMAP -0.354133849124592 0.000541881329246517 NA NA NA hsa-miR-590-3p COL6A6 2.59289455139753 1.03200520972022e-21 -0.602255903025299 0.268075030849075 MirTarget;miRanda;mirMAP -0.307668414170883 0.00119359313360594 NA NA NA hsa-miR-590-5p COL6A6 3.18300989862077 2.06813568597893e-26 -0.602255903025299 0.268075030849075 miRanda -0.306102761505495 0.000297739651563458 NA NA NA hsa-miR-944 COL6A6 2.91186649218281 1.31574753528144e-06 -0.602255903025299 0.268075030849075 mirMAP -0.232933730651902 1.16592074731069e-07 NA NA NA hsa-let-7b-3p COL9A1 0.868207752019623 1.30460056774366e-05 -1.50769693398978 0.0281597021556884 mirMAP -0.443235348809803 0.00809384174936257 NA NA NA hsa-let-7f-1-3p COL9A1 1.55054488387679 7.31326775537952e-11 -1.50769693398978 0.0281597021556884 mirMAP -0.780016507648528 2.25566888821382e-08 NA NA NA hsa-miR-146b-5p COL9A1 1.75587235896724 1.15724631266659e-07 -1.50769693398978 0.0281597021556884 miRanda;miRNATAP -0.996911402245026 1.00332523532714e-26 NA NA NA hsa-miR-29a-3p COL9A1 -0.35074463683376 0.161238718982428 -1.50769693398978 0.0281597021556884 miRNATAP -0.893738437878503 7.93962626929998e-12 NA NA NA hsa-miR-22-3p CREB1 1.21545661147757 1.61670170137775e-13 -0.312030376265328 0.0020768010105899 MirTarget -0.186010640453272 8.60003579233624e-11 NA NA NA hsa-miR-129-5p CREB3L1 -0.524170159980738 0.222582956006346 -1.81228769825907 2.53797773630782e-05 miRanda -0.203198254977423 4.16771780983786e-05 NA NA NA hsa-miR-182-5p CREB3L1 3.53923166221814 5.07781258121574e-21 -1.81228769825907 2.53797773630782e-05 MirTarget -0.390694636450428 3.73594300120646e-14 NA NA NA hsa-miR-320a CREB3L1 0.438165828017084 0.0390159073347133 -1.81228769825907 2.53797773630782e-05 miRanda -0.623154032474716 1.90796789215885e-10 NA NA NA hsa-miR-320b CREB3L1 1.55692969039548 1.41071034251915e-08 -1.81228769825907 2.53797773630782e-05 miRanda -0.61185448005973 4.12536770294659e-17 NA NA NA hsa-miR-342-5p CREB3L1 1.74634624752902 3.89286511372155e-11 -1.81228769825907 2.53797773630782e-05 MirTarget -0.313926565608006 5.24844182521395e-05 NA NA NA hsa-let-7a-5p CREB3L2 0.618599506841644 2.76973453058748e-05 -0.294038759162541 0.166204178889749 mirMAP -0.174951488058896 0.0131727859755199 NA NA NA hsa-let-7b-5p CREB3L2 0.604314269683977 0.00140009936153214 -0.294038759162541 0.166204178889749 mirMAP -0.147870975550214 0.00682827024563084 NA NA NA hsa-let-7d-5p CREB3L2 1.33236798905207 1.1741085658466e-13 -0.294038759162541 0.166204178889749 mirMAP -0.130721523761289 0.0200855087875254 NA NA NA hsa-miR-1271-5p CREB3L2 0.970418832993172 0.000609742584380688 -0.294038759162541 0.166204178889749 MirTarget -0.207243741059178 6.30247277546795e-09 NA NA NA hsa-miR-128-3p CREB3L2 1.63756041666078 6.79626586407187e-14 -0.294038759162541 0.166204178889749 MirTarget -0.125818047972949 0.00605916233638663 NA NA NA hsa-miR-16-2-3p CREB3L2 2.31623086727196 4.29838149388188e-20 -0.294038759162541 0.166204178889749 mirMAP -0.226300158024187 3.57730022482728e-09 NA NA NA hsa-miR-16-5p CREB3L2 1.75824877145857 1.68592440033108e-16 -0.294038759162541 0.166204178889749 miRNAWalker2_validate -0.225961949986943 1.02089089100338e-06 NA NA NA hsa-miR-17-5p CREB3L2 3.2710598467455 9.93128340539455e-27 -0.294038759162541 0.166204178889749 mirMAP -0.185099393061339 2.38840248719623e-09 NA NA NA hsa-miR-181a-5p CREB3L2 2.29556023480783 1.8138457900616e-21 -0.294038759162541 0.166204178889749 mirMAP -0.108063860266651 0.00783932808104565 NA NA NA hsa-miR-181b-5p CREB3L2 2.49307679431293 3.92829250217627e-20 -0.294038759162541 0.166204178889749 mirMAP -0.111969015110739 0.00194951245215726 NA NA NA hsa-miR-186-5p CREB3L2 1.47445398888668 3.0781726595413e-15 -0.294038759162541 0.166204178889749 MirTarget -0.178906276447114 0.0008317898300261 NA NA NA hsa-miR-18a-3p CREB3L2 2.14813400940323 2.23460809936028e-06 -0.294038759162541 0.166204178889749 MirTarget -0.1591404190817 1.06037571256629e-08 NA NA NA hsa-miR-197-3p CREB3L2 1.75733174019505 8.88576793100499e-13 -0.294038759162541 0.166204178889749 mirMAP -0.128640049637877 0.001578266636202 NA NA NA hsa-miR-1976 CREB3L2 2.06550563678192 7.81396978619772e-18 -0.294038759162541 0.166204178889749 MirTarget -0.22586739156851 2.76674216329156e-08 NA NA NA hsa-miR-19b-3p CREB3L2 2.49529833021187 1.57028265846699e-23 -0.294038759162541 0.166204178889749 miRNAWalker2_validate -0.239809804407589 3.88881713707114e-10 NA NA NA hsa-miR-20a-5p CREB3L2 3.15577933619191 4.19753346442454e-25 -0.294038759162541 0.166204178889749 mirMAP -0.192891688602768 6.05644591297745e-10 NA NA NA hsa-miR-2355-3p CREB3L2 1.2671753520641 5.70559238344897e-05 -0.294038759162541 0.166204178889749 mirMAP -0.10193123044731 0.00218956936942546 NA NA NA hsa-miR-2355-5p CREB3L2 1.32510310704724 8.25139516692683e-07 -0.294038759162541 0.166204178889749 MirTarget -0.176225872921955 2.6073954489305e-06 NA NA NA hsa-miR-24-3p CREB3L2 0.99989036772428 1.35595013650376e-07 -0.294038759162541 0.166204178889749 miRNATAP -0.150798451328711 0.00516297314941425 NA NA NA hsa-miR-29b-1-5p CREB3L2 1.55384379072167 4.76870585070176e-05 -0.294038759162541 0.166204178889749 mirMAP -0.170284888009699 8.58969667583114e-10 NA NA NA hsa-miR-361-5p CREB3L2 0.971859117235239 5.30236555707088e-09 -0.294038759162541 0.166204178889749 miRanda -0.155992733886745 0.0112734212762063 NA NA NA hsa-miR-590-3p CREB3L2 2.59289455139753 1.03200520972022e-21 -0.294038759162541 0.166204178889749 miRanda;miRNATAP -0.166413609872621 6.18784910801116e-06 NA NA NA hsa-miR-7-1-3p CREB3L2 1.84950311431067 1.25300363397654e-13 -0.294038759162541 0.166204178889749 mirMAP -0.2082834061791 1.43974468105769e-07 NA NA NA hsa-miR-766-3p CREB3L2 1.2456012547833 6.44584025471128e-06 -0.294038759162541 0.166204178889749 MirTarget -0.137933023533359 0.00017454809347328 NA NA NA hsa-miR-92a-1-5p CREB3L2 2.23721820014467 5.12925824784972e-09 -0.294038759162541 0.166204178889749 MirTarget -0.220123769479357 2.19715950723421e-14 NA NA NA hsa-miR-92a-3p CREB3L2 2.06460102658973 1.44784291084757e-19 -0.294038759162541 0.166204178889749 miRNAWalker2_validate;MirTarget;miRNATAP -0.295133576225333 2.63417199299954e-12 NA NA NA hsa-miR-92b-3p CREB3L2 1.20409245530001 3.41055816361655e-06 -0.294038759162541 0.166204178889749 MirTarget;miRNATAP -0.216462791937008 2.34169368261333e-08 NA NA NA hsa-miR-106a-5p CREB5 2.48882002962836 1.99757727374521e-12 -2.27679484644664 4.56595042875634e-09 MirTarget;miRNATAP -0.27659041406423 1.06737039047926e-07 NA NA NA hsa-miR-106b-5p CREB5 2.46782146831112 1.36171495805632e-23 -2.27679484644664 4.56595042875634e-09 MirTarget;miRNATAP -0.588936900376745 1.32490501616953e-16 NA NA NA hsa-miR-107 CREB5 1.30977326593435 1.30372468603965e-11 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.553618640061941 8.35176543180681e-09 NA NA NA hsa-miR-10a-5p CREB5 1.15016989191194 0.00372037233992369 -2.27679484644664 4.56595042875634e-09 miRNAWalker2_validate -0.314069401016465 2.50617576971364e-11 NA NA NA hsa-miR-125a-5p CREB5 0.599529391575274 0.0102300147180307 -2.27679484644664 4.56595042875634e-09 miRNAWalker2_validate -0.532079783228008 4.14975524303849e-11 NA NA NA hsa-miR-130b-3p CREB5 3.5350292994509 1.73934183852569e-27 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.391059878678443 3.18227850898761e-13 NA NA NA hsa-miR-141-3p CREB5 5.02396127982626 2.19224509139725e-24 -2.27679484644664 4.56595042875634e-09 mirMAP -0.412602227752003 1.82008564281382e-34 NA NA NA hsa-miR-15a-5p CREB5 2.34669284378787 1.69544424500258e-23 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.480024129902558 2.75823037140221e-10 NA NA NA hsa-miR-15b-5p CREB5 1.57112623124278 9.14247846750597e-13 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.350762335480414 3.52066666920358e-05 NA NA NA hsa-miR-16-2-3p CREB5 2.31623086727196 4.29838149388188e-20 -2.27679484644664 4.56595042875634e-09 mirMAP -0.237464095512291 0.00106896944438951 NA NA NA hsa-miR-16-5p CREB5 1.75824877145857 1.68592440033108e-16 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.317454576069402 0.000256003556731818 NA NA NA hsa-miR-17-5p CREB5 3.2710598467455 9.93128340539455e-27 -2.27679484644664 4.56595042875634e-09 MirTarget;TargetScan;miRNATAP -0.336826503541359 6.13213711399823e-09 NA NA NA hsa-miR-182-5p CREB5 3.53923166221814 5.07781258121574e-21 -2.27679484644664 4.56595042875634e-09 mirMAP -0.464348743181962 3.89829884732289e-24 NA NA NA hsa-miR-186-5p CREB5 1.47445398888668 3.0781726595413e-15 -2.27679484644664 4.56595042875634e-09 mirMAP -0.476542580640488 1.56367590241355e-06 NA NA NA hsa-miR-19a-3p CREB5 3.42309334186656 3.02671914353412e-28 -2.27679484644664 4.56595042875634e-09 mirMAP -0.264023178021145 3.92199483401362e-06 NA NA NA hsa-miR-19b-3p CREB5 2.49529833021187 1.57028265846699e-23 -2.27679484644664 4.56595042875634e-09 mirMAP -0.385286121735927 8.5955482338467e-08 NA NA NA hsa-miR-200a-3p CREB5 4.59434485520731 6.38952518573476e-18 -2.27679484644664 4.56595042875634e-09 mirMAP -0.404357595996443 7.11231849401721e-38 NA NA NA hsa-miR-200b-3p CREB5 3.78235093249346 3.18343003239465e-14 -2.27679484644664 4.56595042875634e-09 TargetScan -0.43517123933466 1.33542555805935e-37 NA NA NA hsa-miR-200c-3p CREB5 3.50132673580082 2.42716349086937e-15 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.470215746107068 2.55597087862817e-34 NA NA NA hsa-miR-20a-5p CREB5 3.15577933619191 4.19753346442454e-25 -2.27679484644664 4.56595042875634e-09 MirTarget;miRNATAP -0.348740708102474 2.14661124073769e-09 NA NA NA hsa-miR-20b-5p CREB5 2.07706563022469 1.10107236083433e-05 -2.27679484644664 4.56595042875634e-09 MirTarget;miRNATAP -0.221281274633907 2.1275166639914e-08 NA NA NA hsa-miR-26b-3p CREB5 2.18464160365372 2.11543189388328e-18 -2.27679484644664 4.56595042875634e-09 MirTarget -0.368944103700057 4.40993420819177e-07 NA NA NA hsa-miR-26b-5p CREB5 0.885393662798425 3.2116297961629e-06 -2.27679484644664 4.56595042875634e-09 mirMAP -0.394779902950381 8.30292310972524e-05 NA NA NA hsa-miR-29b-3p CREB5 1.65828197923813 1.02676780888141e-09 -2.27679484644664 4.56595042875634e-09 MirTarget;miRNATAP -0.29121506409998 2.37493055362849e-05 NA NA NA hsa-miR-29c-3p CREB5 -0.00968972577705429 0.97099586346872 -2.27679484644664 4.56595042875634e-09 MirTarget;miRNATAP -0.377107345323848 1.27274679253433e-07 NA NA NA hsa-miR-301a-3p CREB5 2.81024345929638 2.29784847962242e-17 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.415291734535939 3.87227680173868e-13 NA NA NA hsa-miR-3065-3p CREB5 2.16221780121195 9.65525739884541e-09 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.183108784528391 0.000230767821847077 NA NA NA hsa-miR-3065-5p CREB5 2.74629919868982 1.86846589298284e-08 -2.27679484644664 4.56595042875634e-09 mirMAP;miRNATAP -0.148341624699895 0.00166018577224311 NA NA NA hsa-miR-30b-3p CREB5 0.834142820354026 0.000972582820878813 -2.27679484644664 4.56595042875634e-09 MirTarget -0.481129374970507 1.11023970514781e-10 NA NA NA hsa-miR-30d-3p CREB5 0.977747550180601 4.3048212205381e-05 -2.27679484644664 4.56595042875634e-09 mirMAP -0.566735543461382 3.49934309404611e-13 NA NA NA hsa-miR-30e-3p CREB5 -0.215663037684509 0.235375122783546 -2.27679484644664 4.56595042875634e-09 mirMAP -0.389596514026474 0.000254976271668887 NA NA NA hsa-miR-32-3p CREB5 2.02436999565685 5.94091197945307e-09 -2.27679484644664 4.56595042875634e-09 mirMAP -0.252612529618034 3.86384429787335e-05 NA NA NA hsa-miR-32-5p CREB5 2.34056473219422 6.24134585974322e-20 -2.27679484644664 4.56595042875634e-09 miRNAWalker2_validate -0.320216661100292 6.71913199703988e-06 NA NA NA hsa-miR-320a CREB5 0.438165828017084 0.0390159073347133 -2.27679484644664 4.56595042875634e-09 MirTarget;PITA;miRanda;miRNATAP -0.425133569163362 2.39180311891214e-06 NA NA NA hsa-miR-320b CREB5 1.55692969039548 1.41071034251915e-08 -2.27679484644664 4.56595042875634e-09 MirTarget;PITA;miRanda;miRNATAP -0.268865317514937 8.61891110153517e-05 NA NA NA hsa-miR-330-3p CREB5 0.876747334239085 0.00073709016089703 -2.27679484644664 4.56595042875634e-09 MirTarget;mirMAP -0.500171120002088 3.52649700916523e-12 NA NA NA hsa-miR-335-3p CREB5 3.08791651139852 5.31309869723517e-12 -2.27679484644664 4.56595042875634e-09 mirMAP -0.297693696404002 1.93375864362307e-13 NA NA NA hsa-miR-33a-3p CREB5 1.72765312072219 1.51784443453521e-07 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.325353098167413 1.86230609115765e-07 NA NA NA hsa-miR-34a-5p CREB5 1.9016323452565 1.43092834643601e-14 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.504143048020364 7.47790714935664e-12 NA NA NA hsa-miR-3607-3p CREB5 2.68532138541128 5.66716351955047e-14 -2.27679484644664 4.56595042875634e-09 mirMAP -0.280010297263088 1.09717020621525e-07 NA NA NA hsa-miR-361-5p CREB5 0.971859117235239 5.30236555707088e-09 -2.27679484644664 4.56595042875634e-09 PITA;miRNATAP -0.746433858469096 3.09240763807009e-11 NA NA NA hsa-miR-362-5p CREB5 1.59303749908759 9.582675908797e-08 -2.27679484644664 4.56595042875634e-09 PITA -0.145852714876374 0.0213747530644156 NA NA NA hsa-miR-429 CREB5 4.48815175680773 2.44117492218206e-17 -2.27679484644664 4.56595042875634e-09 PITA;miRanda;miRNATAP -0.405942761076876 1.2801698466435e-37 NA NA NA hsa-miR-454-3p CREB5 2.47234127820054 1.12878018736016e-21 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.453372004044335 1.94260777673916e-10 NA NA NA hsa-miR-532-3p CREB5 1.96631878320218 4.53421954361695e-13 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.291122578148666 2.01165522192363e-05 NA NA NA hsa-miR-576-5p CREB5 2.20467023993664 3.4053475193793e-19 -2.27679484644664 4.56595042875634e-09 PITA;mirMAP -0.329997550145364 8.66465936997228e-06 NA NA NA hsa-miR-582-3p CREB5 0.00876844181512659 0.977126166214707 -2.27679484644664 4.56595042875634e-09 MirTarget;PITA;miRNATAP -0.232033986878503 0.000210047860033173 NA NA NA hsa-miR-590-3p CREB5 2.59289455139753 1.03200520972022e-21 -2.27679484644664 4.56595042875634e-09 PITA;mirMAP -0.231550987490698 0.000804467193422777 NA NA NA hsa-miR-590-5p CREB5 3.18300989862077 2.06813568597893e-26 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.312611463776826 3.16345258973896e-07 NA NA NA hsa-miR-671-5p CREB5 2.97733652243246 1.21148452344738e-23 -2.27679484644664 4.56595042875634e-09 PITA -0.39576541552139 4.26962931047325e-10 NA NA NA hsa-miR-7-1-3p CREB5 1.84950311431067 1.25300363397654e-13 -2.27679484644664 4.56595042875634e-09 mirMAP -0.219817616442799 0.0032700297908725 NA NA NA hsa-miR-769-5p CREB5 1.82023760596845 9.6815886564134e-14 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.534461000166633 6.78763599794296e-13 NA NA NA hsa-miR-93-5p CREB5 3.03961860136032 1.11672209617395e-24 -2.27679484644664 4.56595042875634e-09 MirTarget;miRNATAP -0.521282144073032 5.23549013096067e-19 NA NA NA hsa-miR-940 CREB5 3.21011374578759 2.7923171128495e-14 -2.27679484644664 4.56595042875634e-09 MirTarget -0.340504612873848 3.05774321662688e-13 NA NA NA hsa-miR-944 CREB5 2.91186649218281 1.31574753528144e-06 -2.27679484644664 4.56595042875634e-09 MirTarget;PITA;miRNATAP -0.182135253173309 1.15648989570851e-08 NA NA NA hsa-miR-106a-5p CSF1 2.48882002962836 1.99757727374521e-12 -1.29812834960066 0.000329197071112557 miRNATAP -0.292080056920012 8.20083201848244e-10 NA NA NA hsa-miR-106b-5p CSF1 2.46782146831112 1.36171495805632e-23 -1.29812834960066 0.000329197071112557 miRNATAP -0.69490061470497 7.90243746028848e-28 NA NA NA hsa-miR-107 CSF1 1.30977326593435 1.30372468603965e-11 -1.29812834960066 0.000329197071112557 miRanda -0.65400188460506 6.0908696446948e-14 NA NA NA hsa-miR-125a-5p CSF1 0.599529391575274 0.0102300147180307 -1.29812834960066 0.000329197071112557 mirMAP -0.395599645283962 1.22310594058424e-07 NA NA NA hsa-miR-126-5p CSF1 0.895338176458417 2.33372756450713e-05 -1.29812834960066 0.000329197071112557 MirTarget;miRNATAP -0.292616773077932 0.000415105400137839 NA NA NA hsa-miR-128-3p CSF1 1.63756041666078 6.79626586407187e-14 -1.29812834960066 0.000329197071112557 MirTarget -0.50795067112565 4.17877363345535e-11 22909061 By mutations in putative miRNA targets in CSF-1 mRNA 3'UTR we identified a common target for both miR-128 and miR-152; We have also found that both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro two major aspects of the metastatic potential of cancer cells; Our results provide the evidence for a mechanism by which miR-128 and miR-152 down-regulate CSF-1 an important regulator of ovarian cancer motility ovarian cancer hsa-miR-130b-3p CSF1 3.5350292994509 1.73934183852569e-27 -1.29812834960066 0.000329197071112557 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.413305363123187 2.44437309944564e-17 22005523 CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system; CSF-1 expression was negatively associated with miR-130b level in ovarian tissues and cell lines; Luciferase assay validated CSF-1 is a direct target of miR-130b; Knock-down of CSF-1 sensitized ovarian cancer cells to anticancer drugs and could partially attenuate the resistance inducing effect of miR-130b inhibitors; Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1 and the silencing of miR-130b may be mediated by DNA methylation drug resistance ovarian cancer hsa-miR-148a-3p CSF1 1.26728238710376 2.52325607402829e-06 -1.29812834960066 0.000329197071112557 miRNATAP -0.134630091349288 0.0382507130195816 NA NA NA hsa-miR-148b-3p CSF1 1.97815018171325 6.07715327281595e-26 -1.29812834960066 0.000329197071112557 miRNAWalker2_validate -0.749968900030656 1.74792992055792e-18 NA NA NA hsa-miR-149-5p CSF1 2.94200492826326 4.93436498919036e-14 -1.29812834960066 0.000329197071112557 MirTarget -0.372531081954126 5.57485802614607e-19 NA NA NA hsa-miR-15a-5p CSF1 2.34669284378787 1.69544424500258e-23 -1.29812834960066 0.000329197071112557 miRNATAP -0.395936347917719 1.71768468421611e-08 NA NA NA hsa-miR-15b-5p CSF1 1.57112623124278 9.14247846750597e-13 -1.29812834960066 0.000329197071112557 miRNATAP -0.454249669515809 3.8631655360902e-09 NA NA NA hsa-miR-16-5p CSF1 1.75824877145857 1.68592440033108e-16 -1.29812834960066 0.000329197071112557 miRNATAP -0.321250773360689 5.51161953303591e-05 NA NA NA hsa-miR-17-5p CSF1 3.2710598467455 9.93128340539455e-27 -1.29812834960066 0.000329197071112557 TargetScan;miRNATAP -0.393432683762314 7.17228463446697e-14 NA NA NA hsa-miR-185-3p CSF1 2.3922478518806 1.3373426768452e-14 -1.29812834960066 0.000329197071112557 MirTarget;mirMAP -0.296012577204368 4.70219904255403e-08 NA NA NA hsa-miR-197-3p CSF1 1.75733174019505 8.88576793100499e-13 -1.29812834960066 0.000329197071112557 MirTarget -0.385769623681918 2.21886851120176e-08 NA NA NA hsa-miR-205-5p CSF1 4.1389800495524 2.05488295686453e-12 -1.29812834960066 0.000329197071112557 MirTarget -0.16200381192512 1.46887787959612e-08 NA NA NA hsa-miR-20a-5p CSF1 3.15577933619191 4.19753346442454e-25 -1.29812834960066 0.000329197071112557 miRNATAP -0.388374611075354 2.29955388371609e-13 NA NA NA hsa-miR-20b-5p CSF1 2.07706563022469 1.10107236083433e-05 -1.29812834960066 0.000329197071112557 miRNATAP -0.21226609801527 4.72517148739017e-09 NA NA NA hsa-miR-27b-3p CSF1 0.196007704287769 0.295630157035388 -1.29812834960066 0.000329197071112557 MirTarget;miRNATAP -0.392660450968279 3.33841189043943e-05 NA NA NA hsa-miR-28-5p CSF1 0.230152919654905 0.0742909586754846 -1.29812834960066 0.000329197071112557 miRNATAP -0.482898682197754 0.000591286322752508 NA NA NA hsa-miR-301a-3p CSF1 2.81024345929638 2.29784847962242e-17 -1.29812834960066 0.000329197071112557 MirTarget;miRNATAP -0.441964619265934 1.84949991758876e-17 NA NA NA hsa-miR-30b-5p CSF1 0.800822374912712 0.000133601914525413 -1.29812834960066 0.000329197071112557 miRNAWalker2_validate -0.647748467026495 1.76347580346489e-15 NA NA NA hsa-miR-30c-5p CSF1 0.778774633108 0.000285599212429136 -1.29812834960066 0.000329197071112557 miRNAWalker2_validate -0.587084492967281 2.10465961570436e-13 NA NA NA hsa-miR-326 CSF1 0.715313016136042 0.0610265683213359 -1.29812834960066 0.000329197071112557 mirMAP -0.113146917373644 0.0145655982560214 NA NA NA hsa-miR-335-5p CSF1 1.77247705492746 2.22457658872091e-06 -1.29812834960066 0.000329197071112557 miRNAWalker2_validate -0.322452532010456 1.0532896202219e-12 NA NA NA hsa-miR-423-5p CSF1 0.963563145758616 9.86109015204915e-07 -1.29812834960066 0.000329197071112557 miRNATAP -0.771654302751225 1.73604836579277e-19 NA NA NA hsa-miR-429 CSF1 4.48815175680773 2.44117492218206e-17 -1.29812834960066 0.000329197071112557 PITA;miRanda;miRNATAP -0.413388052202471 3.36128581785197e-48 NA NA NA hsa-miR-454-3p CSF1 2.47234127820054 1.12878018736016e-21 -1.29812834960066 0.000329197071112557 MirTarget;miRNATAP -0.439709113912521 1.61603625404065e-11 NA NA NA hsa-miR-491-5p CSF1 0.615770352820862 0.0418295628761654 -1.29812834960066 0.000329197071112557 miRanda -0.19854150149161 0.00145414860040171 NA NA NA hsa-miR-505-3p CSF1 1.45322244209148 8.86597629645867e-10 -1.29812834960066 0.000329197071112557 miRNAWalker2_validate -0.311700580263137 1.79723365848452e-05 NA NA NA hsa-miR-532-3p CSF1 1.96631878320218 4.53421954361695e-13 -1.29812834960066 0.000329197071112557 MirTarget;PITA -0.425228567430688 5.43141552036115e-12 NA NA NA hsa-miR-532-5p CSF1 1.55697650978597 1.57884735535196e-11 -1.29812834960066 0.000329197071112557 miRNATAP -0.493295481153669 1.53150016526314e-11 NA NA NA hsa-miR-93-5p CSF1 3.03961860136032 1.11672209617395e-24 -1.29812834960066 0.000329197071112557 miRNATAP -0.577183088546093 4.392495537145e-28 NA NA NA hsa-miR-940 CSF1 3.21011374578759 2.7923171128495e-14 -1.29812834960066 0.000329197071112557 MirTarget;PITA;miRNATAP -0.379143291597792 2.81890189158455e-19 NA NA NA hsa-miR-96-5p CSF1 4.89433085814374 1.92000659886961e-31 -1.29812834960066 0.000329197071112557 miRNATAP -0.428523288509248 7.08622996271483e-31 NA NA NA hsa-miR-107 CSF1R 1.30977326593435 1.30372468603965e-11 -1.04722118455631 0.017969966085107 miRanda -0.894015814449865 2.03071082250236e-17 NA NA NA hsa-miR-339-5p CSF1R 2.68710938429893 3.03134080808154e-16 -1.04722118455631 0.017969966085107 miRanda -0.230136953690785 0.000242843989086468 NA NA NA hsa-miR-34a-5p CSF1R 1.9016323452565 1.43092834643601e-14 -1.04722118455631 0.017969966085107 MirTarget;miRNATAP -0.461603981922354 2.97565476458688e-08 NA NA NA hsa-miR-141-3p CSF3 5.02396127982626 2.19224509139725e-24 -4.55276205983688 3.03447416692714e-08 TargetScan;miRNATAP -0.537552891809218 9.56020415551903e-13 NA NA NA hsa-miR-200a-3p CSF3 4.59434485520731 6.38952518573476e-18 -4.55276205983688 3.03447416692714e-08 miRNATAP -0.613641665377399 1.46471374322596e-18 NA NA NA hsa-miR-2110 CSF3 1.16625590651194 6.4784195289885e-05 -4.55276205983688 3.03447416692714e-08 miRNATAP -0.300198540131011 0.0431949985613654 NA NA NA hsa-miR-28-5p CSF3 0.230152919654905 0.0742909586754846 -4.55276205983688 3.03447416692714e-08 miRanda -0.636623692387695 0.0498690704905897 NA NA NA hsa-miR-532-3p CSF3 1.96631878320218 4.53421954361695e-13 -4.55276205983688 3.03447416692714e-08 MirTarget;miRNATAP -0.511596023696386 0.000408144598083793 NA NA NA hsa-miR-30b-3p CSF3R 0.834142820354026 0.000972582820878813 -0.24235997663033 0.563434741685528 MirTarget -0.338117174033944 2.41732637318943e-05 NA NA NA hsa-miR-361-5p CSF3R 0.971859117235239 5.30236555707088e-09 -0.24235997663033 0.563434741685528 miRanda -0.59066961558745 9.29010565293858e-07 NA NA NA hsa-miR-429 CSF3R 4.48815175680773 2.44117492218206e-17 -0.24235997663033 0.563434741685528 miRanda -0.219611610587113 1.11577253202234e-09 NA NA NA hsa-miR-940 CSF3R 3.21011374578759 2.7923171128495e-14 -0.24235997663033 0.563434741685528 MirTarget -0.292773888151162 4.72591342870772e-09 NA NA NA hsa-miR-101-3p DDIT4 0.522819989585461 0.00375627731618038 0.717938757137077 0.0430461225180125 miRNAWalker2_validate;MirTarget;miRNATAP -0.355155844720243 0.00021315858646136 NA NA NA hsa-miR-181c-5p DDIT4 1.58587920618301 1.57506918816933e-10 0.717938757137077 0.0430461225180125 MirTarget -0.145077871296069 0.0335547857337937 NA NA NA hsa-miR-181d-5p DDIT4 1.52204912185579 9.2693319057748e-08 0.717938757137077 0.0430461225180125 MirTarget -0.127310279952917 0.0330653294977689 NA NA NA hsa-miR-30b-5p DDIT4 0.800822374912712 0.000133601914525413 0.717938757137077 0.0430461225180125 MirTarget -0.231516620607933 0.00481015325205432 NA NA NA hsa-miR-30c-5p DDIT4 0.778774633108 0.000285599212429136 0.717938757137077 0.0430461225180125 MirTarget;miRNATAP -0.189580566588003 0.0182756104343371 NA NA NA hsa-miR-30d-5p DDIT4 0.675423997639582 0.00270618816039773 0.717938757137077 0.0430461225180125 MirTarget;miRNATAP -0.233442309312649 0.00227699320721357 NA NA NA hsa-miR-30e-5p DDIT4 1.23904909539663 1.35561917122157e-09 0.717938757137077 0.0430461225180125 MirTarget -0.279318696597116 0.000764635783021267 NA NA NA hsa-miR-32-5p DDIT4 2.34056473219422 6.24134585974322e-20 0.717938757137077 0.0430461225180125 miRNATAP -0.250841298923405 8.90809727205639e-05 NA NA NA hsa-miR-218-5p EFNA1 -0.573801507392184 0.0551983860126703 1.57576504257657 1.43564310601553e-08 miRNAWalker2_validate -0.209616001114161 3.90667195526562e-06 NA NA NA hsa-miR-30c-2-3p EFNA1 -1.66877185449987 3.97071129111399e-10 1.57576504257657 1.43564310601553e-08 MirTarget -0.113710824218287 0.0242130759669385 NA NA NA hsa-miR-145-5p EFNA3 -1.55259331973517 9.97889123247165e-07 1.9208300847997 6.87246410078639e-11 miRNATAP -0.212987435059083 2.25875368357263e-06 NA NA NA hsa-miR-30a-5p EFNA3 -0.878357906436456 0.000509952992366057 1.9208300847997 6.87246410078639e-11 MirTarget;mirMAP;miRNATAP -0.239909917479981 2.83842328485723e-05 NA NA NA hsa-miR-199a-5p EFNA5 0.592984035153911 0.0674836634175293 0.0978937038765233 0.793271139378603 PITA;miRanda -0.122752051393565 0.027775220515751 NA NA NA hsa-miR-338-3p EFNA5 0.453166438193782 0.144583389707558 0.0978937038765233 0.793271139378603 miRanda;miRNATAP -0.129331723724849 0.0265647264736599 NA NA NA hsa-miR-125a-5p EGFR 0.599529391575274 0.0102300147180307 -0.229170429190265 0.593897211976523 mirMAP -0.455142512240812 2.58435389092739e-07 19881956;27094723;24484870 We report that EGFR signaling leads to transcriptional repression of the miRNA miR-125a through the ETS family transcription factor PEA3;Suppression of microRNA 125a 5p upregulates the TAZ EGFR signaling pathway and promotes retinoblastoma proliferation; Moreover the overexpression of miR-125a-5p led to a decrease in TAZ expression and downstream EGFR signaling pathway activation both in vitro and vivo; Finally TAZ overexpression in retinoblastoma cells overexpressing miR-125a-5p restored retinoblastoma cell proliferation and EGFR pathway activation; Taken together our data demonstrated that miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma;miR 125a regulates cell cycle proliferation and apoptosis by targeting the ErbB pathway in acute myeloid leukemia; Profiling revealed the ErbB pathway as significantly decreased with ectopic miR-125a; Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic agents for treating miR-125a-low AML ;progression;progression ovarian cancer;retinoblastoma;acute myeloid leukemia hsa-miR-128-3p EGFR 1.63756041666078 6.79626586407187e-14 -0.229170429190265 0.593897211976523 miRNAWalker2_validate;miRTarBase -0.202545235408722 0.029374382947331 NA NA NA hsa-miR-140-5p EGFR 0.844753502512594 3.73722278438606e-05 -0.229170429190265 0.593897211976523 miRanda -0.290336016621899 0.00422174515988415 NA NA NA hsa-miR-148b-5p EGFR 2.18024067300781 2.84770452413262e-14 -0.229170429190265 0.593897211976523 mirMAP -0.287604854162764 0.000103760310070035 NA NA NA hsa-miR-17-5p EGFR 3.2710598467455 9.93128340539455e-27 -0.229170429190265 0.593897211976523 TargetScan -0.128743012821673 0.0441608856474895 NA NA NA hsa-miR-186-5p EGFR 1.47445398888668 3.0781726595413e-15 -0.229170429190265 0.593897211976523 mirMAP -0.330064150409367 0.0023537398913317 NA NA NA hsa-miR-192-5p EGFR 2.69002528723195 1.22990188194432e-16 -0.229170429190265 0.593897211976523 mirMAP -0.142745422121227 0.0206689451740369 NA NA NA hsa-miR-195-3p EGFR -0.658653229922836 0.0142127125129199 -0.229170429190265 0.593897211976523 mirMAP -0.161748110776139 0.0406071095905996 24282590 Plasma levels of miR-195 and miR-122 expression were also associated with overall survival in the patients especially in those with advanced stage HR=0.23 95%CI:0.07-0.84; and HR=0.22 95%CI:0.06-0.77 and EGFR mutation HR=0.27 95%CI:0.08-0.96; and HR=0.23 95%CI=0.06-0.81; Circulating miR-195 and miR-122 may have prognostic values in predicting the overall survival as well as predicting EGFR mutation status in non-smoking female patients with lung adenocarcinoma; Measuring plasma levels of miR-195 and miR-122 may especially be useful in EGFR mutant patients with lung adenocarcinoma staging;poor survival lung cancer hsa-miR-200a-3p EGFR 4.59434485520731 6.38952518573476e-18 -0.229170429190265 0.593897211976523 MirTarget -0.167369688006813 6.24721098372953e-06 19671845;26184032 Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells;MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion ;drug resistance;cell migration bladder cancer;lung squamous cell cancer hsa-miR-29b-2-5p EGFR 0.910668640983475 0.00666655585493488 -0.229170429190265 0.593897211976523 mirMAP -0.416042511145117 5.70054998722675e-12 NA NA NA hsa-miR-30d-3p EGFR 0.977747550180601 4.3048212205381e-05 -0.229170429190265 0.593897211976523 mirMAP -0.297777237144485 0.000583685262316395 NA NA NA hsa-miR-30e-3p EGFR -0.215663037684509 0.235375122783546 -0.229170429190265 0.593897211976523 mirMAP -0.258675937752403 0.025934094827771 NA NA NA hsa-miR-32-3p EGFR 2.02436999565685 5.94091197945307e-09 -0.229170429190265 0.593897211976523 mirMAP -0.140511240373734 0.0362137719766625 NA NA NA hsa-miR-320a EGFR 0.438165828017084 0.0390159073347133 -0.229170429190265 0.593897211976523 miRanda;mirMAP -0.237441545432742 0.0161714500455112 NA NA NA hsa-miR-335-5p EGFR 1.77247705492746 2.22457658872091e-06 -0.229170429190265 0.593897211976523 miRNAWalker2_validate -0.107777488168613 0.0497360336107625 NA NA NA hsa-miR-342-3p EGFR 1.49115144672245 1.43879249744621e-07 -0.229170429190265 0.593897211976523 miRanda -0.145868494821454 0.0444309022820605 NA NA NA hsa-miR-362-5p EGFR 1.59303749908759 9.582675908797e-08 -0.229170429190265 0.593897211976523 mirMAP -0.241167685764662 0.00042775566379085 NA NA NA hsa-miR-374a-3p EGFR 0.533309330504947 0.00192918429705142 -0.229170429190265 0.593897211976523 mirMAP -0.472580799180365 0.000102592756227524 NA NA NA hsa-miR-374b-3p EGFR 0.930487774873495 2.74420094310516e-05 -0.229170429190265 0.593897211976523 mirMAP -0.31457186042627 0.000782176493255895 NA NA NA hsa-miR-3913-5p EGFR 2.44353493655328 8.95279496632448e-15 -0.229170429190265 0.593897211976523 mirMAP -0.259753924250973 7.19865795250564e-05 NA NA NA hsa-miR-7-1-3p EGFR 1.84950311431067 1.25300363397654e-13 -0.229170429190265 0.593897211976523 mirMAP -0.211992850385644 0.00900776269242333 NA NA NA hsa-miR-769-5p EGFR 1.82023760596845 9.6815886564134e-14 -0.229170429190265 0.593897211976523 mirMAP -0.205393584719106 0.0132200012753408 NA NA NA hsa-miR-103a-3p EIF4B 1.44083190496858 1.53799939616416e-13 -0.83546386425099 1.60081741236658e-10 MirTarget;miRNATAP -0.12384012181884 0.000120527401673825 NA NA NA hsa-miR-107 EIF4B 1.30977326593435 1.30372468603965e-11 -0.83546386425099 1.60081741236658e-10 MirTarget;PITA;miRanda;miRNATAP -0.116267081967539 0.000376104753401664 NA NA NA hsa-miR-15a-5p EIF4B 2.34669284378787 1.69544424500258e-23 -0.83546386425099 1.60081741236658e-10 miRNATAP -0.115102898094679 8.58712735181583e-06 NA NA NA hsa-miR-15b-5p EIF4B 1.57112623124278 9.14247846750597e-13 -0.83546386425099 1.60081741236658e-10 miRNATAP -0.108417564399088 0.000145863770523161 NA NA NA hsa-miR-16-5p EIF4B 1.75824877145857 1.68592440033108e-16 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.116626867681087 6.27326636466319e-05 NA NA NA hsa-miR-185-5p EIF4B 2.34016206907488 1.17481626642022e-26 -0.83546386425099 1.60081741236658e-10 MirTarget -0.163628340278415 2.05665506314812e-09 NA NA NA hsa-miR-193a-3p EIF4B 1.60460546928078 2.86169793322984e-07 -0.83546386425099 1.60081741236658e-10 miRanda -0.129748653727289 7.39065685686338e-11 NA NA NA hsa-miR-193b-3p EIF4B 2.25711804611899 4.1940744806631e-14 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.131575191324763 1.39505544343809e-10 NA NA NA hsa-miR-25-3p EIF4B 1.36472605225697 4.83790725935681e-11 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.106392733880944 0.000481532722887453 NA NA NA hsa-miR-342-3p EIF4B 1.49115144672245 1.43879249744621e-07 -0.83546386425099 1.60081741236658e-10 miRanda -0.126332356229928 1.1049251414087e-08 NA NA NA hsa-miR-362-3p EIF4B 2.0756816987665 3.89026064579331e-12 -0.83546386425099 1.60081741236658e-10 miRanda -0.161499044149002 1.7968030077065e-14 NA NA NA hsa-miR-423-3p EIF4B 2.57855385753676 9.19765570228097e-24 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.131931378309889 1.88384562098769e-08 NA NA NA hsa-miR-424-5p EIF4B 1.61930224569578 1.89642549274994e-10 -0.83546386425099 1.60081741236658e-10 miRNATAP -0.129745405637866 1.30304622694912e-07 NA NA NA hsa-miR-484 EIF4B 1.81844463411787 1.82951571230938e-15 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.115522506643854 2.13739109619376e-05 NA NA NA hsa-miR-532-3p EIF4B 1.96631878320218 4.53421954361695e-13 -0.83546386425099 1.60081741236658e-10 miRNATAP -0.138783439415054 9.6358571664864e-10 NA NA NA hsa-miR-590-3p EIF4B 2.59289455139753 1.03200520972022e-21 -0.83546386425099 1.60081741236658e-10 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.10810967510776 2.80808517421654e-06 NA NA NA hsa-miR-18a-3p EPHA2 2.14813400940323 2.23460809936028e-06 -0.234132006099067 0.472564048282971 MirTarget -0.178224503892159 3.54857111587131e-05 NA NA NA hsa-miR-127-3p EPOR -0.6279281852298 0.0400829468424132 0.703445818437044 0.0162854092732735 miRanda -0.164542296686865 0.000379158445729522 NA NA NA hsa-miR-214-3p EPOR -0.176344800034733 0.642485503428886 0.703445818437044 0.0162854092732735 mirMAP -0.105240778426839 0.00503968400148828 NA NA NA hsa-let-7a-5p F2R 0.618599506841644 2.76973453058748e-05 0.37017651252301 0.208395486059484 miRNAWalker2_validate -0.401598918793147 3.61815226015563e-05 NA NA NA hsa-miR-16-2-3p F2R 2.31623086727196 4.29838149388188e-20 0.37017651252301 0.208395486059484 mirMAP -0.13181632892599 0.0147772714190523 NA NA NA hsa-miR-190a-5p F2R 0.762748400660219 0.0035950590410453 0.37017651252301 0.208395486059484 MirTarget -0.154236663520985 0.00467754507641373 NA NA NA hsa-miR-23b-3p F2R -0.251132426825047 0.150200321210792 0.37017651252301 0.208395486059484 MirTarget -0.245375364557187 0.00301568449005737 NA NA NA hsa-miR-361-5p F2R 0.971859117235239 5.30236555707088e-09 0.37017651252301 0.208395486059484 miRanda -0.419594274003515 6.72567928631366e-07 NA NA NA hsa-miR-429 F2R 4.48815175680773 2.44117492218206e-17 0.37017651252301 0.208395486059484 miRanda -0.189294813800805 3.65539737286281e-14 NA NA NA hsa-miR-582-5p F2R 0.609226359812689 0.032988717891497 0.37017651252301 0.208395486059484 MirTarget -0.201702925263897 4.78222634675714e-05 NA NA NA hsa-miR-664a-3p F2R 0.634721925861133 0.00520070178640421 0.37017651252301 0.208395486059484 mirMAP -0.396367555079308 1.27524170129215e-10 NA NA NA hsa-let-7e-5p FASLG 0.860104282510173 6.04758298373779e-05 -0.196180452389551 0.711804379159628 miRNATAP -0.681095573446369 7.73237301751494e-09 NA NA NA hsa-miR-324-5p FASLG 2.95683728155095 1.32960514360912e-20 -0.196180452389551 0.711804379159628 miRanda -0.190742358117509 0.0133843611744564 NA NA NA hsa-miR-126-5p FGF1 0.895338176458417 2.33372756450713e-05 -0.0184880339301951 0.962515192576832 mirMAP -0.257052884478014 0.00418426830473386 NA NA NA hsa-miR-16-1-3p FGF1 2.56983217111073 3.02262181237943e-20 -0.0184880339301951 0.962515192576832 mirMAP -0.342294668806123 2.38586503825089e-07 NA NA NA hsa-miR-186-5p FGF1 1.47445398888668 3.0781726595413e-15 -0.0184880339301951 0.962515192576832 mirMAP -0.591026951034186 1.46187678760819e-09 NA NA NA hsa-miR-18a-5p FGF1 3.78535678765353 3.72446596213886e-26 -0.0184880339301951 0.962515192576832 MirTarget -0.264847474948657 3.88610261864251e-07 NA NA NA hsa-miR-205-5p FGF1 4.1389800495524 2.05488295686453e-12 -0.0184880339301951 0.962515192576832 mirMAP -0.157775223845845 3.59117960754949e-07 NA NA NA hsa-miR-26b-3p FGF1 2.18464160365372 2.11543189388328e-18 -0.0184880339301951 0.962515192576832 MirTarget -0.423230901828247 4.44177310978311e-09 NA NA NA hsa-miR-28-5p FGF1 0.230152919654905 0.0742909586754846 -0.0184880339301951 0.962515192576832 miRanda -0.307527561468243 0.0437651717819831 NA NA NA hsa-miR-320a FGF1 0.438165828017084 0.0390159073347133 -0.0184880339301951 0.962515192576832 miRanda -0.541959251848306 9.85803319868347e-10 NA NA NA hsa-miR-320b FGF1 1.55692969039548 1.41071034251915e-08 -0.0184880339301951 0.962515192576832 miRanda -0.407239237545482 1.30349593223329e-09 NA NA NA hsa-miR-330-5p FGF1 1.15100069700871 4.85551805046014e-07 -0.0184880339301951 0.962515192576832 miRanda;miRNATAP -0.439171157719847 7.15817077978881e-08 NA NA NA hsa-miR-361-5p FGF1 0.971859117235239 5.30236555707088e-09 -0.0184880339301951 0.962515192576832 miRanda -0.85349859964158 1.1628109767779e-14 NA NA NA hsa-miR-374a-3p FGF1 0.533309330504947 0.00192918429705142 -0.0184880339301951 0.962515192576832 mirMAP -0.278029489012277 0.0129779340815342 NA NA NA hsa-miR-3913-5p FGF1 2.44353493655328 8.95279496632448e-15 -0.0184880339301951 0.962515192576832 mirMAP -0.302608268342126 3.69363193887853e-07 NA NA NA hsa-miR-429 FGF1 4.48815175680773 2.44117492218206e-17 -0.0184880339301951 0.962515192576832 miRNATAP -0.267128349292686 9.69262295730924e-16 NA NA NA hsa-miR-484 FGF1 1.81844463411787 1.82951571230938e-15 -0.0184880339301951 0.962515192576832 MirTarget;PITA;miRNATAP -0.394116689453691 8.31708710335926e-07 NA NA NA hsa-miR-532-3p FGF1 1.96631878320218 4.53421954361695e-13 -0.0184880339301951 0.962515192576832 miRNATAP -0.440506181753794 4.21772989420151e-11 NA NA NA hsa-miR-550a-5p FGF1 2.11025227932763 6.94489556637146e-12 -0.0184880339301951 0.962515192576832 MirTarget -0.275012193152473 4.64050292544223e-06 NA NA NA hsa-miR-576-5p FGF1 2.20467023993664 3.4053475193793e-19 -0.0184880339301951 0.962515192576832 PITA;mirMAP -0.300128298067083 4.75057034180223e-05 NA NA NA hsa-miR-590-5p FGF1 3.18300989862077 2.06813568597893e-26 -0.0184880339301951 0.962515192576832 MirTarget;miRanda;miRNATAP -0.343013546630031 1.40984845888558e-08 NA NA NA hsa-miR-625-5p FGF1 1.42540152147292 1.95797147911206e-06 -0.0184880339301951 0.962515192576832 MirTarget -0.161347567906741 0.0196143505347662 NA NA NA hsa-miR-629-5p FGF1 2.10182419359635 1.51788571125757e-15 -0.0184880339301951 0.962515192576832 MirTarget -0.165152261467362 0.01825143480828 NA NA NA hsa-miR-944 FGF1 2.91186649218281 1.31574753528144e-06 -0.0184880339301951 0.962515192576832 mirMAP -0.186547406811606 3.74734066850436e-09 NA NA NA hsa-miR-125b-5p FGF11 -1.16462950151259 0.000288900271798384 2.36629832780319 2.81026571264635e-10 mirMAP -0.245248887594589 1.73977327404226e-05 NA NA NA hsa-miR-195-5p FGF11 -1.44753678070504 8.70594292149271e-09 2.36629832780319 2.81026571264635e-10 mirMAP -0.349749547573844 1.22998816790053e-06 NA NA NA hsa-let-7f-1-3p FGF12 1.55054488387679 7.31326775537952e-11 -0.105634203581597 0.830798911418477 MirTarget -0.333111119559479 0.00101034935003356 NA NA NA hsa-miR-29a-5p FGF12 1.46749674755271 3.34605004270294e-07 -0.105634203581597 0.830798911418477 MirTarget -0.321702074213926 0.00020374538956914 NA NA NA hsa-miR-455-5p FGF12 2.2582442061694 1.43472128037398e-13 -0.105634203581597 0.830798911418477 miRanda -0.240066682606252 0.00156512301970859 NA NA NA hsa-miR-511-5p FGF12 1.04499312543772 0.00234126154508174 -0.105634203581597 0.830798911418477 MirTarget -0.142574968993441 0.0404259365193597 NA NA NA hsa-let-7a-3p FGF13 1.42015538786275 7.03375209382654e-13 -2.79657067303141 1.56359356599715e-14 MirTarget;miRNATAP -0.476927207954888 9.11116431267741e-08 NA NA NA hsa-let-7b-3p FGF13 0.868207752019623 1.30460056774366e-05 -2.79657067303141 1.56359356599715e-14 MirTarget;miRNATAP -0.330311915944346 0.000291860606001036 NA NA NA hsa-let-7f-1-3p FGF13 1.55054488387679 7.31326775537952e-11 -2.79657067303141 1.56359356599715e-14 MirTarget -0.449044682518558 3.65397965548342e-09 NA NA NA hsa-let-7g-3p FGF13 3.26398061402445 3.96263126107645e-25 -2.79657067303141 1.56359356599715e-14 miRNATAP -0.407085198701305 7.16106489006225e-14 NA NA NA hsa-miR-141-3p FGF13 5.02396127982626 2.19224509139725e-24 -2.79657067303141 1.56359356599715e-14 TargetScan -0.302898746415501 8.87758287571865e-20 NA NA NA hsa-miR-200a-5p FGF13 3.86316681673704 1.81076942093171e-15 -2.79657067303141 1.56359356599715e-14 MirTarget;miRNATAP -0.21982450079845 5.72965300252089e-10 NA NA NA hsa-miR-200b-5p FGF13 2.54484902707822 1.59240467582976e-06 -2.79657067303141 1.56359356599715e-14 MirTarget -0.225797054463804 1.92722376445309e-09 NA NA NA hsa-miR-3065-3p FGF13 2.16221780121195 9.65525739884541e-09 -2.79657067303141 1.56359356599715e-14 MirTarget;miRNATAP -0.190085596758735 5.63840821082238e-05 NA NA NA hsa-miR-3065-5p FGF13 2.74629919868982 1.86846589298284e-08 -2.79657067303141 1.56359356599715e-14 MirTarget;mirMAP;miRNATAP -0.209349645962154 2.57152126823624e-06 NA NA NA hsa-miR-31-3p FGF13 2.70807981248858 8.84479434501203e-05 -2.79657067303141 1.56359356599715e-14 miRNATAP -0.185125316927806 4.97759365271198e-11 NA NA NA hsa-miR-34c-5p FGF13 2.07190852984647 7.35776320806257e-08 -2.79657067303141 1.56359356599715e-14 miRanda -0.174558299761964 0.00042811021121569 NA NA NA hsa-miR-421 FGF13 1.17791565395543 6.78526676976629e-06 -2.79657067303141 1.56359356599715e-14 MirTarget;PITA;miRanda;miRNATAP -0.272548837534654 7.748381820303e-05 NA NA NA hsa-miR-429 FGF13 4.48815175680773 2.44117492218206e-17 -2.79657067303141 1.56359356599715e-14 miRNATAP -0.206395285212018 1.65735860319463e-10 NA NA NA hsa-miR-455-5p FGF13 2.2582442061694 1.43472128037398e-13 -2.79657067303141 1.56359356599715e-14 PITA;miRanda -0.308345140645582 7.0083826972615e-08 NA NA NA hsa-miR-511-5p FGF13 1.04499312543772 0.00234126154508174 -2.79657067303141 1.56359356599715e-14 MirTarget -0.14578918114989 0.00585401970078833 NA NA NA hsa-miR-590-3p FGF13 2.59289455139753 1.03200520972022e-21 -2.79657067303141 1.56359356599715e-14 miRanda -0.50056116303806 4.23454497035437e-15 NA NA NA hsa-miR-7-1-3p FGF13 1.84950311431067 1.25300363397654e-13 -2.79657067303141 1.56359356599715e-14 MirTarget;mirMAP -0.404511369528413 7.64132929406128e-09 NA NA NA hsa-miR-362-3p FGF14 2.0756816987665 3.89026064579331e-12 -1.46844557178328 0.00268591599153301 miRanda -0.174455542190821 0.0298517218143074 NA NA NA hsa-miR-421 FGF14 1.17791565395543 6.78526676976629e-06 -1.46844557178328 0.00268591599153301 miRanda -0.637683195269129 4.6282816865839e-13 NA NA NA hsa-miR-590-3p FGF14 2.59289455139753 1.03200520972022e-21 -1.46844557178328 0.00268591599153301 miRanda -0.549518148621001 6.75806376569127e-11 NA NA NA hsa-miR-96-5p FGF14 4.89433085814374 1.92000659886961e-31 -1.46844557178328 0.00268591599153301 TargetScan -0.32531579054151 7.90142217061031e-10 NA NA NA hsa-miR-103a-3p FGF18 1.44083190496858 1.53799939616416e-13 -1.42483047022124 0.00103718898766565 miRNATAP -0.356068506298048 0.000774817673325315 NA NA NA hsa-miR-107 FGF18 1.30977326593435 1.30372468603965e-11 -1.42483047022124 0.00103718898766565 miRNATAP -0.425066640569775 7.22213089698089e-05 NA NA NA hsa-miR-15a-5p FGF18 2.34669284378787 1.69544424500258e-23 -1.42483047022124 0.00103718898766565 miRNATAP -0.464224982406698 3.74903170207201e-08 NA NA NA hsa-miR-15b-5p FGF18 1.57112623124278 9.14247846750597e-13 -1.42483047022124 0.00103718898766565 miRNATAP -0.618422336678395 1.80376185685917e-11 NA NA NA hsa-miR-16-5p FGF18 1.75824877145857 1.68592440033108e-16 -1.42483047022124 0.00103718898766565 miRNATAP -0.716652518248879 1.53715937075798e-14 NA NA NA hsa-miR-200b-3p FGF18 3.78235093249346 3.18343003239465e-14 -1.42483047022124 0.00103718898766565 TargetScan -0.155406687950871 0.000140098893382056 NA NA NA hsa-miR-200c-3p FGF18 3.50132673580082 2.42716349086937e-15 -1.42483047022124 0.00103718898766565 miRNATAP -0.257330688592158 1.44969551897125e-08 NA NA NA hsa-miR-21-5p FGF18 2.73773305747971 1.38864982139576e-43 -1.42483047022124 0.00103718898766565 miRNATAP -0.441803837579941 4.23160631739167e-06 NA NA NA hsa-miR-330-5p FGF18 1.15100069700871 4.85551805046014e-07 -1.42483047022124 0.00103718898766565 PITA;miRanda;miRNATAP -0.343613128640874 0.000170129552940752 NA NA NA hsa-miR-421 FGF18 1.17791565395543 6.78526676976629e-06 -1.42483047022124 0.00103718898766565 miRanda -0.170620072639481 0.0341592805461428 NA NA NA hsa-miR-424-5p FGF18 1.61930224569578 1.89642549274994e-10 -1.42483047022124 0.00103718898766565 miRNATAP -0.26186546069637 0.00131478568853092 NA NA NA hsa-miR-429 FGF18 4.48815175680773 2.44117492218206e-17 -1.42483047022124 0.00103718898766565 miRNATAP -0.135424427434448 0.000379262258909638 NA NA NA hsa-miR-505-3p FGF18 1.45322244209148 8.86597629645867e-10 -1.42483047022124 0.00103718898766565 miRNATAP -0.493018097870616 1.21245467333208e-08 NA NA NA hsa-miR-590-5p FGF18 3.18300989862077 2.06813568597893e-26 -1.42483047022124 0.00103718898766565 miRanda;miRNATAP -0.376932190079452 2.06770613305322e-08 NA NA NA hsa-let-7a-3p FGF2 1.42015538786275 7.03375209382654e-13 -3.45935256477983 3.20406041037898e-17 mirMAP -0.57039623316549 1.64408016446008e-08 NA NA NA hsa-let-7b-3p FGF2 0.868207752019623 1.30460056774366e-05 -3.45935256477983 3.20406041037898e-17 mirMAP -0.530485029047925 2.33230657638534e-07 NA NA NA hsa-let-7f-1-3p FGF2 1.55054488387679 7.31326775537952e-11 -3.45935256477983 3.20406041037898e-17 mirMAP -0.403619323347166 3.50383349222099e-06 NA NA NA hsa-miR-103a-3p FGF2 1.44083190496858 1.53799939616416e-13 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.951198901738798 5.80167380051094e-22 NA NA NA hsa-miR-107 FGF2 1.30977326593435 1.30372468603965e-11 -3.45935256477983 3.20406041037898e-17 MirTarget;PITA;miRanda;miRNATAP -0.746537045946991 3.12339725479843e-13 NA NA NA hsa-miR-10b-3p FGF2 0.77597971642517 0.00264877454133753 -3.45935256477983 3.20406041037898e-17 mirMAP -0.38765486044307 1.00531657460278e-06 NA NA NA hsa-miR-1226-3p FGF2 1.38118928579963 0.000205503474787488 -3.45935256477983 3.20406041037898e-17 MirTarget -0.406312709645584 4.86442323802081e-11 NA NA NA hsa-miR-126-5p FGF2 0.895338176458417 2.33372756450713e-05 -3.45935256477983 3.20406041037898e-17 mirMAP -0.221461498102424 0.0233691135465993 NA NA NA hsa-miR-144-3p FGF2 0.658119849508907 0.146943823997989 -3.45935256477983 3.20406041037898e-17 MirTarget -0.150660886736508 0.00130127640996876 NA NA NA hsa-miR-148a-5p FGF2 1.16173838132242 0.000148929299881612 -3.45935256477983 3.20406041037898e-17 mirMAP -0.175801486236704 0.00879070967495281 NA NA NA hsa-miR-15a-5p FGF2 2.34669284378787 1.69544424500258e-23 -3.45935256477983 3.20406041037898e-17 MirTarget;miRNATAP -0.8665754259228 1.51865052824555e-28 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 2.33847028227712 4.29662877950836e-19 -3.45935256477983 3.20406041037898e-17 mirMAP -0.698237395560323 2.98047943363042e-22 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 1.57112623124278 9.14247846750597e-13 -3.45935256477983 3.20406041037898e-17 MirTarget;miRNATAP -0.772339849603923 2.2379572945642e-18 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 2.56983217111073 3.02262181237943e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.706717215195114 8.84760087286705e-25 NA NA NA hsa-miR-16-2-3p FGF2 2.31623086727196 4.29838149388188e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.642959805706348 1.63529117433717e-17 NA NA NA hsa-miR-16-5p FGF2 1.75824877145857 1.68592440033108e-16 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.791482784689716 1.7414135213028e-18 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-181a-5p FGF2 2.29556023480783 1.8138457900616e-21 -3.45935256477983 3.20406041037898e-17 mirMAP -0.525450431942733 5.3421915793276e-11 NA NA NA hsa-miR-181b-5p FGF2 2.49307679431293 3.92829250217627e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.487813576366985 7.1537699850524e-12 NA NA NA hsa-miR-181c-5p FGF2 1.58587920618301 1.57506918816933e-10 -3.45935256477983 3.20406041037898e-17 mirMAP -0.402853563332211 6.66481994248428e-07 NA NA NA hsa-miR-186-5p FGF2 1.47445398888668 3.0781726595413e-15 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate;mirMAP -0.865396245604199 9.71640315277788e-17 NA NA NA hsa-miR-192-5p FGF2 2.69002528723195 1.22990188194432e-16 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.55945113419736 8.27439417486679e-22 NA NA NA hsa-miR-19b-1-5p FGF2 2.57951428759379 4.31576118703427e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.684742945615863 1.47856020889472e-23 NA NA NA hsa-miR-200b-3p FGF2 3.78235093249346 3.18343003239465e-14 -3.45935256477983 3.20406041037898e-17 mirMAP -0.442848247331966 6.36624370256829e-33 NA NA NA hsa-miR-200c-3p FGF2 3.50132673580082 2.42716349086937e-15 -3.45935256477983 3.20406041037898e-17 mirMAP -0.581898672989235 1.2281612826909e-47 NA NA NA hsa-miR-20a-3p FGF2 2.92621109947706 2.49504904635375e-17 -3.45935256477983 3.20406041037898e-17 mirMAP -0.521338868643764 2.37178789361296e-20 NA NA NA hsa-miR-21-3p FGF2 2.19296355304364 4.63665722759779e-15 -3.45935256477983 3.20406041037898e-17 mirMAP -0.389762818312192 3.3064358783093e-08 NA NA NA hsa-miR-21-5p FGF2 2.73773305747971 1.38864982139576e-43 -3.45935256477983 3.20406041037898e-17 mirMAP -0.590129232102637 2.05709217680526e-10 NA NA NA hsa-miR-215-5p FGF2 2.30755467422978 2.38476032118039e-06 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.234704807386955 3.03139328926694e-08 NA NA NA hsa-miR-29a-5p FGF2 1.46749674755271 3.34605004270294e-07 -3.45935256477983 3.20406041037898e-17 mirMAP -0.184223429205561 0.0142842130111975 NA NA NA hsa-miR-32-5p FGF2 2.34056473219422 6.24134585974322e-20 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.528631961245202 2.37324737115731e-12 NA NA NA hsa-miR-330-3p FGF2 0.876747334239085 0.00073709016089703 -3.45935256477983 3.20406041037898e-17 mirMAP -0.408493425882602 1.96553818290449e-07 NA NA NA hsa-miR-335-3p FGF2 3.08791651139852 5.31309869723517e-12 -3.45935256477983 3.20406041037898e-17 mirMAP -0.283343671500426 1.16812423839489e-10 NA NA NA hsa-miR-335-5p FGF2 1.77247705492746 2.22457658872091e-06 -3.45935256477983 3.20406041037898e-17 miRNATAP -0.204481115239778 0.000164239409089154 NA NA NA hsa-miR-361-5p FGF2 0.971859117235239 5.30236555707088e-09 -3.45935256477983 3.20406041037898e-17 mirMAP -1.05676685455326 5.59900406122503e-19 NA NA NA hsa-miR-374a-3p FGF2 0.533309330504947 0.00192918429705142 -3.45935256477983 3.20406041037898e-17 mirMAP -0.25459376280057 0.0364309341812607 NA NA NA hsa-miR-424-5p FGF2 1.61930224569578 1.89642549274994e-10 -3.45935256477983 3.20406041037898e-17 MirTarget;miRNATAP -0.199023712638781 0.0127013546608619 NA NA NA hsa-miR-429 FGF2 4.48815175680773 2.44117492218206e-17 -3.45935256477983 3.20406041037898e-17 mirMAP -0.410445998774638 1.8378122494787e-32 NA NA NA hsa-miR-450b-5p FGF2 1.69244418548325 1.68064054148881e-10 -3.45935256477983 3.20406041037898e-17 mirMAP -0.300742012229277 7.83074250991869e-05 NA NA NA hsa-miR-452-5p FGF2 1.37180058737183 0.00171494843537772 -3.45935256477983 3.20406041037898e-17 mirMAP -0.212195200331281 5.19684741170909e-06 NA NA NA hsa-miR-503-5p FGF2 3.66513190181895 6.60300917645278e-21 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.407288478531313 2.50922381458507e-15 NA NA NA hsa-miR-589-3p FGF2 2.51971841868825 2.39125940264107e-11 -3.45935256477983 3.20406041037898e-17 mirMAP -0.381356804586547 1.66276905891645e-10 NA NA NA hsa-miR-590-3p FGF2 2.59289455139753 1.03200520972022e-21 -3.45935256477983 3.20406041037898e-17 miRanda;mirMAP -0.518258185319804 1.08846109843951e-12 NA NA NA hsa-miR-590-5p FGF2 3.18300989862077 2.06813568597893e-26 -3.45935256477983 3.20406041037898e-17 miRanda;mirMAP -0.632565141691195 1.29154238410301e-23 NA NA NA hsa-miR-664a-3p FGF2 0.634721925861133 0.00520070178640421 -3.45935256477983 3.20406041037898e-17 mirMAP -0.355728775133404 9.0166815375644e-05 NA NA NA hsa-miR-92a-3p FGF2 2.06460102658973 1.44784291084757e-19 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.899992154982756 2.08015519442665e-28 NA NA NA hsa-miR-93-3p FGF2 2.85383869771942 5.64481766902125e-23 -3.45935256477983 3.20406041037898e-17 mirMAP -0.750363342236745 4.93373884627099e-33 NA NA NA hsa-miR-944 FGF2 2.91186649218281 1.31574753528144e-06 -3.45935256477983 3.20406041037898e-17 MirTarget -0.33196588658737 1.10637179732889e-23 NA NA NA hsa-let-7a-5p FGF5 0.618599506841644 2.76973453058748e-05 0.295109479545415 0.629573395554456 TargetScan -0.91814617286066 5.32530775182813e-06 NA NA NA hsa-miR-126-5p FGF5 0.895338176458417 2.33372756450713e-05 0.295109479545415 0.629573395554456 mirMAP -0.292433990899961 0.0367033438214469 NA NA NA hsa-miR-16-1-3p FGF5 2.56983217111073 3.02262181237943e-20 0.295109479545415 0.629573395554456 mirMAP -0.338734686460559 0.00113538866111799 NA NA NA hsa-miR-30b-5p FGF5 0.800822374912712 0.000133601914525413 0.295109479545415 0.629573395554456 mirMAP -0.600640883736003 1.90348300406499e-05 NA NA NA hsa-miR-30c-5p FGF5 0.778774633108 0.000285599212429136 0.295109479545415 0.629573395554456 mirMAP -0.92040630911618 9.17796831458907e-12 NA NA NA hsa-miR-30d-5p FGF5 0.675423997639582 0.00270618816039773 0.295109479545415 0.629573395554456 mirMAP -1.13295918526447 3.0017545458782e-19 NA NA NA hsa-miR-30e-5p FGF5 1.23904909539663 1.35561917122157e-09 0.295109479545415 0.629573395554456 mirMAP -1.15649538412346 5.357826498539e-17 NA NA NA hsa-miR-335-3p FGF5 3.08791651139852 5.31309869723517e-12 0.295109479545415 0.629573395554456 mirMAP -0.141715092084903 0.0276862615076123 NA NA NA hsa-miR-33a-3p FGF5 1.72765312072219 1.51784443453521e-07 0.295109479545415 0.629573395554456 mirMAP -0.539068199759696 2.08072885141182e-08 NA NA NA hsa-miR-3607-3p FGF5 2.68532138541128 5.66716351955047e-14 0.295109479545415 0.629573395554456 miRNATAP -0.234633949263568 0.00441910591787781 NA NA NA hsa-miR-361-5p FGF5 0.971859117235239 5.30236555707088e-09 0.295109479545415 0.629573395554456 miRanda -0.526008521902236 0.00299705315333712 NA NA NA hsa-miR-3913-5p FGF5 2.44353493655328 8.95279496632448e-15 0.295109479545415 0.629573395554456 mirMAP -0.454773813139765 9.34182245565845e-07 NA NA NA hsa-miR-425-5p FGF5 3.07071373939774 4.02947460586085e-25 0.295109479545415 0.629573395554456 mirMAP -0.36043366586368 0.000119548832083508 NA NA NA hsa-miR-582-5p FGF5 0.609226359812689 0.032988717891497 0.295109479545415 0.629573395554456 mirMAP -0.50108445051561 1.06699099148979e-06 NA NA NA hsa-let-7a-3p FGF7 1.42015538786275 7.03375209382654e-13 -3.51313263207438 7.95527572408387e-12 MirTarget;miRNATAP -0.868051763208098 2.15246923266363e-12 NA NA NA hsa-let-7b-3p FGF7 0.868207752019623 1.30460056774366e-05 -3.51313263207438 7.95527572408387e-12 MirTarget;miRNATAP -0.686098645885029 5.95476501085241e-08 NA NA NA hsa-let-7f-1-3p FGF7 1.55054488387679 7.31326775537952e-11 -3.51313263207438 7.95527572408387e-12 MirTarget -0.422294734283416 9.10473994373525e-05 NA NA NA hsa-miR-107 FGF7 1.30977326593435 1.30372468603965e-11 -3.51313263207438 7.95527572408387e-12 PITA;miRanda;miRNATAP -1.33350776374428 6.88980795931608e-28 NA NA NA hsa-miR-125a-3p FGF7 1.24490295132072 5.26925231010328e-06 -3.51313263207438 7.95527572408387e-12 miRanda -0.36428154542973 7.97695913996567e-05 NA NA NA hsa-miR-126-5p FGF7 0.895338176458417 2.33372756450713e-05 -3.51313263207438 7.95527572408387e-12 miRNATAP -0.50607130713236 2.39566802274335e-05 NA NA NA hsa-miR-15a-5p FGF7 2.34669284378787 1.69544424500258e-23 -3.51313263207438 7.95527572408387e-12 miRTarBase;miRNATAP -1.05153766439707 1.95358882887929e-27 NA NA NA hsa-miR-15b-5p FGF7 1.57112623124278 9.14247846750597e-13 -3.51313263207438 7.95527572408387e-12 miRNATAP -1.2675059921588 1.34716750524093e-33 NA NA NA hsa-miR-16-1-3p FGF7 2.56983217111073 3.02262181237943e-20 -3.51313263207438 7.95527572408387e-12 mirMAP -0.962633495741247 1.30046319779539e-30 NA NA NA hsa-miR-16-2-3p FGF7 2.31623086727196 4.29838149388188e-20 -3.51313263207438 7.95527572408387e-12 mirMAP -1.03435039613724 1.94620052074685e-30 NA NA NA hsa-miR-16-5p FGF7 1.75824877145857 1.68592440033108e-16 -3.51313263207438 7.95527572408387e-12 miRNATAP -1.28612319073303 4.51638848249496e-33 NA NA NA hsa-miR-18a-3p FGF7 2.14813400940323 2.23460809936028e-06 -3.51313263207438 7.95527572408387e-12 MirTarget -0.556498884313971 2.26092390202209e-16 NA NA NA hsa-miR-20a-5p FGF7 3.15577933619191 4.19753346442454e-25 -3.51313263207438 7.95527572408387e-12 miRNAWalker2_validate -0.868623781957236 1.39584172420003e-32 NA NA NA hsa-miR-26b-5p FGF7 0.885393662798425 3.2116297961629e-06 -3.51313263207438 7.95527572408387e-12 mirMAP -0.847719846249514 1.19855193491048e-10 NA NA NA hsa-miR-27a-3p FGF7 1.66542180327138 4.93775737894805e-13 -3.51313263207438 7.95527572408387e-12 MirTarget -0.496262584130317 3.80940705649825e-06 NA NA NA hsa-miR-30d-3p FGF7 0.977747550180601 4.3048212205381e-05 -3.51313263207438 7.95527572408387e-12 miRNATAP -0.98464350645187 2.65309361395091e-22 NA NA NA hsa-miR-31-5p FGF7 3.59165123035072 2.27423212057482e-07 -3.51313263207438 7.95527572408387e-12 MirTarget -0.242511081652209 1.15595308501103e-10 NA NA NA hsa-miR-320a FGF7 0.438165828017084 0.0390159073347133 -3.51313263207438 7.95527572408387e-12 miRanda -0.863658740998593 2.38979957240199e-13 NA NA NA hsa-miR-320b FGF7 1.55692969039548 1.41071034251915e-08 -3.51313263207438 7.95527572408387e-12 miRanda -0.8900673002199 8.8221661934298e-25 NA NA NA hsa-miR-33a-3p FGF7 1.72765312072219 1.51784443453521e-07 -3.51313263207438 7.95527572408387e-12 mirMAP -0.869749595956586 2.33649296944708e-28 NA NA NA hsa-miR-3607-3p FGF7 2.68532138541128 5.66716351955047e-14 -3.51313263207438 7.95527572408387e-12 mirMAP -0.64929482323457 8.99724661665848e-22 NA NA NA hsa-miR-361-5p FGF7 0.971859117235239 5.30236555707088e-09 -3.51313263207438 7.95527572408387e-12 PITA;miRanda;miRNATAP -1.56289686557936 1.23555434322998e-27 NA NA NA hsa-miR-374a-3p FGF7 0.533309330504947 0.00192918429705142 -3.51313263207438 7.95527572408387e-12 miRNATAP -0.673095249598969 6.22712424951211e-06 NA NA NA hsa-miR-421 FGF7 1.17791565395543 6.78526676976629e-06 -3.51313263207438 7.95527572408387e-12 miRanda -0.61796765882037 8.36534413441402e-11 NA NA NA hsa-miR-424-5p FGF7 1.61930224569578 1.89642549274994e-10 -3.51313263207438 7.95527572408387e-12 miRNATAP -0.233014906775338 0.0182660772823141 NA NA NA hsa-miR-429 FGF7 4.48815175680773 2.44117492218206e-17 -3.51313263207438 7.95527572408387e-12 miRNATAP -0.443581603298994 3.06942783866656e-24 NA NA NA hsa-miR-452-5p FGF7 1.37180058737183 0.00171494843537772 -3.51313263207438 7.95527572408387e-12 mirMAP -0.249611725832981 1.47380993562818e-05 NA NA NA hsa-miR-455-3p FGF7 3.06093594997644 3.54590649799868e-16 -3.51313263207438 7.95527572408387e-12 PITA;miRNATAP -0.607725997000264 1.53851303208614e-22 NA NA NA hsa-miR-484 FGF7 1.81844463411787 1.82951571230938e-15 -3.51313263207438 7.95527572408387e-12 PITA -0.960272098641967 1.85266514198687e-20 NA NA NA hsa-miR-486-5p FGF7 -0.194913133034028 0.607377798807705 -3.51313263207438 7.95527572408387e-12 MirTarget;miRanda -0.350475600632684 1.38246507581354e-07 NA NA NA hsa-miR-501-5p FGF7 1.93654809410041 1.3779381780759e-10 -3.51313263207438 7.95527572408387e-12 PITA;mirMAP -0.377449765945373 8.38821662648711e-06 NA NA NA hsa-miR-582-3p FGF7 0.00876844181512659 0.977126166214707 -3.51313263207438 7.95527572408387e-12 PITA;miRNATAP -0.444512234576302 7.58144669390707e-08 NA NA NA hsa-miR-590-3p FGF7 2.59289455139753 1.03200520972022e-21 -3.51313263207438 7.95527572408387e-12 PITA;miRanda;mirMAP;miRNATAP -0.837742801847946 1.56917534011074e-21 NA NA NA hsa-miR-590-5p FGF7 3.18300989862077 2.06813568597893e-26 -3.51313263207438 7.95527572408387e-12 PITA;miRanda -0.82452421363643 1.87090418897067e-26 NA NA NA hsa-miR-7-1-3p FGF7 1.84950311431067 1.25300363397654e-13 -3.51313263207438 7.95527572408387e-12 mirMAP -0.853688804833789 4.05730521370535e-19 NA NA NA hsa-miR-944 FGF7 2.91186649218281 1.31574753528144e-06 -3.51313263207438 7.95527572408387e-12 mirMAP -0.392489693630891 1.34607680998663e-21 NA NA NA hsa-miR-142-3p FGF9 2.75247908790621 1.45636065474764e-12 -4.26095125698269 8.03301928631002e-16 miRanda -0.304602080556944 3.74420488921244e-06 NA NA NA hsa-miR-142-5p FGF9 1.17581605694506 0.0018174701991234 -4.26095125698269 8.03301928631002e-16 mirMAP -0.238268156517486 0.000658901150979571 NA NA NA hsa-miR-155-5p FGF9 1.20164021433135 0.00086170622431261 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.185157637778622 0.0115744159152895 NA NA NA hsa-miR-15a-5p FGF9 2.34669284378787 1.69544424500258e-23 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.613515930639976 6.81151068408031e-09 NA NA NA hsa-miR-15b-5p FGF9 1.57112623124278 9.14247846750597e-13 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.802569271834457 3.63021724126861e-12 NA NA NA hsa-miR-16-2-3p FGF9 2.31623086727196 4.29838149388188e-20 -4.26095125698269 8.03301928631002e-16 mirMAP -0.800367524866385 2.04134354031929e-16 NA NA NA hsa-miR-16-5p FGF9 1.75824877145857 1.68592440033108e-16 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.883505660298818 5.27035859785824e-14 NA NA NA hsa-miR-181a-5p FGF9 2.29556023480783 1.8138457900616e-21 -4.26095125698269 8.03301928631002e-16 mirMAP -0.489899182058424 2.6269594131992e-06 NA NA NA hsa-miR-181b-5p FGF9 2.49307679431293 3.92829250217627e-20 -4.26095125698269 8.03301928631002e-16 mirMAP -0.508260400727932 3.82554365417734e-08 NA NA NA hsa-miR-182-5p FGF9 3.53923166221814 5.07781258121574e-21 -4.26095125698269 8.03301928631002e-16 miRTarBase;miRNATAP -0.199763187583912 0.00291090860779188 NA NA NA hsa-miR-183-5p FGF9 4.19757025992371 4.79612296318304e-26 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.247497021287039 7.27398434498139e-05 NA NA NA hsa-miR-186-5p FGF9 1.47445398888668 3.0781726595413e-15 -4.26095125698269 8.03301928631002e-16 mirMAP -0.699532502904695 3.5394259788128e-07 NA NA NA hsa-miR-205-5p FGF9 4.1389800495524 2.05488295686453e-12 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.326036683952424 1.66736877723578e-14 NA NA NA hsa-miR-212-3p FGF9 0.357878936470387 0.232446214501331 -4.26095125698269 8.03301928631002e-16 mirMAP -0.242923523642108 0.00659695119245421 NA NA NA hsa-miR-221-5p FGF9 -0.745357436702497 0.081887809839391 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.131681550115797 0.0378970860932215 NA NA NA hsa-miR-26b-5p FGF9 0.885393662798425 3.2116297961629e-06 -4.26095125698269 8.03301928631002e-16 miRNAWalker2_validate -0.463461132249546 0.00089179354119325 NA NA NA hsa-miR-32-3p FGF9 2.02436999565685 5.94091197945307e-09 -4.26095125698269 8.03301928631002e-16 mirMAP -0.424513773785253 5.42028936260741e-07 NA NA NA hsa-miR-320b FGF9 1.55692969039548 1.41071034251915e-08 -4.26095125698269 8.03301928631002e-16 mirMAP;miRNATAP -0.355538591217071 0.000183486822496139 NA NA NA hsa-miR-330-5p FGF9 1.15100069700871 4.85551805046014e-07 -4.26095125698269 8.03301928631002e-16 miRanda;miRNATAP -0.423366003580199 0.000230055048357782 NA NA NA hsa-miR-3607-3p FGF9 2.68532138541128 5.66716351955047e-14 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.24313494691515 0.000999639918173201 NA NA NA hsa-miR-424-5p FGF9 1.61930224569578 1.89642549274994e-10 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.58737553539275 6.18032575679243e-09 NA NA NA hsa-miR-450b-5p FGF9 1.69244418548325 1.68064054148881e-10 -4.26095125698269 8.03301928631002e-16 mirMAP;miRNATAP -0.340701382488691 0.000517592246201871 NA NA NA hsa-miR-455-5p FGF9 2.2582442061694 1.43472128037398e-13 -4.26095125698269 8.03301928631002e-16 miRanda -0.514569349219032 5.600682082645e-10 NA NA NA hsa-miR-500a-5p FGF9 1.72110365584658 3.0807246212659e-10 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.305215850049758 0.00136645365694185 NA NA NA hsa-miR-501-3p FGF9 1.83132758513743 1.10971547702065e-10 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.275213501706133 0.00266614535053256 NA NA NA hsa-miR-502-3p FGF9 1.50560877085049 1.2647489756373e-11 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.472515714777411 5.16045988653371e-05 NA NA NA hsa-miR-590-3p FGF9 2.59289455139753 1.03200520972022e-21 -4.26095125698269 8.03301928631002e-16 miRanda;mirMAP -0.634218650148273 1.44459862312323e-11 NA NA NA hsa-miR-590-5p FGF9 3.18300989862077 2.06813568597893e-26 -4.26095125698269 8.03301928631002e-16 miRanda -0.585459859087567 2.600352130665e-12 NA NA NA hsa-miR-744-3p FGF9 2.7517405670917 4.22040908411227e-14 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.478257215030822 4.08425547781364e-12 NA NA NA hsa-miR-944 FGF9 2.91186649218281 1.31574753528144e-06 -4.26095125698269 8.03301928631002e-16 mirMAP -0.299847632396488 8.53539059567662e-12 NA NA NA hsa-miR-96-5p FGF9 4.89433085814374 1.92000659886961e-31 -4.26095125698269 8.03301928631002e-16 TargetScan;miRNATAP -0.27635466915326 3.67018504641498e-06 NA NA NA hsa-miR-106a-5p FGFR1 2.48882002962836 1.99757727374521e-12 -2.87837421637657 3.11921581471297e-13 mirMAP -0.384049482399962 3.23721514703937e-13 NA NA NA hsa-miR-106b-5p FGFR1 2.46782146831112 1.36171495805632e-23 -2.87837421637657 3.11921581471297e-13 mirMAP -0.786989656536899 1.34893666834924e-28 NA NA NA hsa-miR-10a-5p FGFR1 1.15016989191194 0.00372037233992369 -2.87837421637657 3.11921581471297e-13 miRNAWalker2_validate -0.337275460563786 2.76715914740678e-12 21738581 Predicted target mRNAs FGFR1 miR-10 and MLH1 miR-155 were found downregulated pancreatic cancer hsa-miR-135b-5p FGFR1 3.62510365056501 1.09148980810091e-10 -2.87837421637657 3.11921581471297e-13 mirMAP -0.256448226944969 3.75332453789719e-13 NA NA NA hsa-miR-15a-5p FGFR1 2.34669284378787 1.69544424500258e-23 -2.87837421637657 3.11921581471297e-13 miRNATAP -0.754714476564242 1.61012864706111e-23 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGFR1 1.57112623124278 9.14247846750597e-13 -2.87837421637657 3.11921581471297e-13 miRNATAP -0.775708333138364 1.99211850175655e-20 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 1.75824877145857 1.68592440033108e-16 -2.87837421637657 3.11921581471297e-13 miRTarBase;miRNATAP -0.872588788016778 5.80543636431341e-25 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 3.2710598467455 9.93128340539455e-27 -2.87837421637657 3.11921581471297e-13 mirMAP -0.561714096530076 1.45885352023962e-22 NA NA NA hsa-miR-181b-5p FGFR1 2.49307679431293 3.92829250217627e-20 -2.87837421637657 3.11921581471297e-13 miRNAWalker2_validate -0.302065593540415 1.18303842029487e-05 NA NA NA hsa-miR-200a-5p FGFR1 3.86316681673704 1.81076942093171e-15 -2.87837421637657 3.11921581471297e-13 mirMAP -0.445799640285698 2.0477017707227e-35 NA NA NA hsa-miR-200b-5p FGFR1 2.54484902707822 1.59240467582976e-06 -2.87837421637657 3.11921581471297e-13 mirMAP -0.423363595037777 9.00824115860094e-28 NA NA NA hsa-miR-20a-5p FGFR1 3.15577933619191 4.19753346442454e-25 -2.87837421637657 3.11921581471297e-13 mirMAP -0.555458710370069 9.61690870294644e-22 NA NA NA hsa-miR-20b-5p FGFR1 2.07706563022469 1.10107236083433e-05 -2.87837421637657 3.11921581471297e-13 mirMAP -0.209937819299542 2.53129403166548e-07 NA NA NA hsa-miR-2355-5p FGFR1 1.32510310704724 8.25139516692683e-07 -2.87837421637657 3.11921581471297e-13 mirMAP -0.145841227639719 0.0448899716316109 NA NA NA hsa-miR-301a-3p FGFR1 2.81024345929638 2.29784847962242e-17 -2.87837421637657 3.11921581471297e-13 mirMAP -0.457918632801525 5.01605114375097e-15 NA NA NA hsa-miR-3065-5p FGFR1 2.74629919868982 1.86846589298284e-08 -2.87837421637657 3.11921581471297e-13 mirMAP -0.223732992343918 3.37250597920076e-06 NA NA NA hsa-miR-330-3p FGFR1 0.876747334239085 0.00073709016089703 -2.87837421637657 3.11921581471297e-13 PITA;miRNATAP -0.559474382786579 2.73100688103047e-14 NA NA NA hsa-miR-330-5p FGFR1 1.15100069700871 4.85551805046014e-07 -2.87837421637657 3.11921581471297e-13 miRanda;miRNATAP -0.598697666333084 6.64556149251227e-13 NA NA NA hsa-miR-335-3p FGFR1 3.08791651139852 5.31309869723517e-12 -2.87837421637657 3.11921581471297e-13 mirMAP -0.228197239098805 6.49231469692864e-08 NA NA NA hsa-miR-361-5p FGFR1 0.971859117235239 5.30236555707088e-09 -2.87837421637657 3.11921581471297e-13 miRanda -0.92653502351532 4.53500138468749e-16 NA NA NA hsa-miR-455-5p FGFR1 2.2582442061694 1.43472128037398e-13 -2.87837421637657 3.11921581471297e-13 miRanda -0.195533414771426 0.00177055042135951 NA NA NA hsa-miR-532-5p FGFR1 1.55697650978597 1.57884735535196e-11 -2.87837421637657 3.11921581471297e-13 PITA -0.322395452372313 0.000108234147627559 NA NA NA hsa-miR-590-3p FGFR1 2.59289455139753 1.03200520972022e-21 -2.87837421637657 3.11921581471297e-13 miRanda;mirMAP -0.57572040519455 4.81539975802524e-17 NA NA NA hsa-miR-744-5p FGFR1 1.48254348878737 3.23019501613577e-09 -2.87837421637657 3.11921581471297e-13 miRNAWalker2_validate -0.538473651654813 1.02221972010418e-12 NA NA NA hsa-miR-93-5p FGFR1 3.03961860136032 1.11672209617395e-24 -2.87837421637657 3.11921581471297e-13 mirMAP -0.600996333108956 4.3413966207049e-24 NA NA NA hsa-let-7a-3p FGFR2 1.42015538786275 7.03375209382654e-13 -1.10510536599184 0.0128825317606034 miRNATAP -0.403668699840633 0.000151473399712384 NA NA NA hsa-let-7b-3p FGFR2 0.868207752019623 1.30460056774366e-05 -1.10510536599184 0.0128825317606034 mirMAP;miRNATAP -0.309687251123528 0.00423048135274253 NA NA NA hsa-miR-107 FGFR2 1.30977326593435 1.30372468603965e-11 -1.10510536599184 0.0128825317606034 PITA;miRanda -0.398153526215925 0.00027439034373613 NA NA NA hsa-miR-126-5p FGFR2 0.895338176458417 2.33372756450713e-05 -1.10510536599184 0.0128825317606034 mirMAP;miRNATAP -0.403452572621652 6.82252178653857e-05 NA NA NA hsa-miR-146b-5p FGFR2 1.75587235896724 1.15724631266659e-07 -1.10510536599184 0.0128825317606034 miRanda -0.146244445164253 0.022817620173302 NA NA NA hsa-miR-186-5p FGFR2 1.47445398888668 3.0781726595413e-15 -1.10510536599184 0.0128825317606034 miRNAWalker2_validate -0.471854892718397 2.53033898213571e-05 NA NA NA hsa-miR-193a-3p FGFR2 1.60460546928078 2.86169793322984e-07 -1.10510536599184 0.0128825317606034 miRanda -0.184992348766107 0.00659604280779591 NA NA NA hsa-miR-19b-1-5p FGFR2 2.57951428759379 4.31576118703427e-20 -1.10510536599184 0.0128825317606034 miRNAWalker2_validate;miRTarBase -0.4345309219133 4.77765562006864e-09 NA NA NA hsa-miR-324-5p FGFR2 2.95683728155095 1.32960514360912e-20 -1.10510536599184 0.0128825317606034 miRanda -0.24680525694008 0.000127710806173706 NA NA NA hsa-miR-338-3p FGFR2 0.453166438193782 0.144583389707558 -1.10510536599184 0.0128825317606034 miRanda;miRNATAP -0.263518769420772 0.000141261313872914 NA NA NA hsa-miR-423-3p FGFR2 2.57855385753676 9.19765570228097e-24 -1.10510536599184 0.0128825317606034 PITA;miRNATAP -0.233949308012158 0.00330874395567353 NA NA NA hsa-miR-590-3p FGFR2 2.59289455139753 1.03200520972022e-21 -1.10510536599184 0.0128825317606034 miRanda -0.311141579023723 6.00872154446622e-05 NA NA NA hsa-miR-628-5p FGFR2 0.799263053510813 2.28892357418044e-05 -1.10510536599184 0.0128825317606034 PITA;miRNATAP -0.568329203893148 5.54144600332728e-07 NA NA NA hsa-miR-100-5p FGFR3 -1.48442967087177 1.5610956769298e-05 1.15552976289114 0.0896174662454542 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.39236626068709 3.31966324164684e-05 23778527;25344675;26604796;26018508 Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress;MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3 poor survival;;; bladder cancer;pancreatic cancer;glioblastoma;sarcoma hsa-miR-142-3p FGFR3 2.75247908790621 1.45636065474764e-12 1.15552976289114 0.0896174662454542 miRanda -0.216798137380456 0.00854904538212289 NA NA NA hsa-miR-99a-5p FGFR3 -1.90541207788117 1.19082238183432e-05 1.15552976289114 0.0896174662454542 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.278809233789285 0.00018764039323491 23409016;24456664;23298836 Photofrin based photodynamic therapy and miR 99a transfection inhibited FGFR3 and PI3K/Akt signaling mechanisms to control growth of human glioblastoma In vitro and in vivo; Further photofrin based PDT followed by miR-99a transfection dramatically increased miR-99a expression and also increased apoptosis in glioblastoma cell cultures and drastically reduced tumor growth in athymic nude mice due to down regulation of fibroblast growth factor receptor 3 FGFR3 and PI3K/Akt signaling mechanisms leading to inhibition of cell proliferation and induction of molecular mechanisms of apoptosis;miR 99a promotes proliferation targeting FGFR3 in human epithelial ovarian cancer cells; Importantly fibroblast growth factor receptor 3 FGFR3 predicted to be one target gene of miR-99a using computational algorithms was higher in expression in EOC cells; Subsequently FGFR3 was proved to be direct target of miR-99a by dual luciferase assay; Furthermore overexpression of miR-99a dramatically suppressed expression level of FGFR3 at both mRNA and protein levels proving FGFR3 to be inversely correlated with miR-99a; Finally overexpression of miR-99a could significantly inhibit EOC cell proliferation in vitro by decreasing the expression of FGFR3 which also reduced the EOC cell growth after siRNA knockdown; Conclusively miR-99a expression was remarkably downregulated in serums tissues and cell and suppresses EOC cell proliferation by targeting FGFR3 suggesting miR-99a as a prospective prognosis marker and potential tumor suppressor for EOC therapeutics;The tumorigenic FGFR3 TACC3 gene fusion escapes miR 99a regulation in glioblastoma; The fusion caused by tandem duplication on 4p16.3 led to the loss of the 3'-UTR of FGFR3 blocking gene regulation of miR-99a and enhancing expression of the fusion gene ;worse prognosis; glioblastoma;ovarian cancer;glioblastoma hsa-miR-146b-5p FLT1 1.75587235896724 1.15724631266659e-07 -0.398798139585047 0.102684609418445 miRanda -0.159935179058735 4.56535177014795e-06 NA NA NA hsa-miR-155-5p FLT1 1.20164021433135 0.00086170622431261 -0.398798139585047 0.102684609418445 miRNAWalker2_validate;mirMAP -0.124036074181 0.000133378861297828 NA NA NA hsa-miR-19a-3p FLT1 3.42309334186656 3.02671914353412e-28 -0.398798139585047 0.102684609418445 MirTarget -0.142945164779521 5.3933264147706e-05 NA NA NA hsa-miR-19b-3p FLT1 2.49529833021187 1.57028265846699e-23 -0.398798139585047 0.102684609418445 MirTarget -0.181991444657249 4.7083327417296e-05 NA NA NA hsa-miR-29a-5p FLT1 1.46749674755271 3.34605004270294e-07 -0.398798139585047 0.102684609418445 MirTarget -0.124373949621283 0.00379603474183942 NA NA NA hsa-miR-339-5p FLT1 2.68710938429893 3.03134080808154e-16 -0.398798139585047 0.102684609418445 miRanda -0.173745122508606 4.02337703117215e-07 NA NA NA hsa-miR-590-3p FLT1 2.59289455139753 1.03200520972022e-21 -0.398798139585047 0.102684609418445 miRanda -0.132919196101858 0.00184001108177259 NA NA NA hsa-miR-125a-5p FLT3 0.599529391575274 0.0102300147180307 -1.96802952624864 2.65981345780205e-05 miRanda -0.263480704467921 0.0074248734779586 NA NA NA hsa-miR-491-5p FLT3 0.615770352820862 0.0418295628761654 -1.96802952624864 2.65981345780205e-05 miRanda -0.22212906907477 0.00622648817980623 NA NA NA hsa-miR-590-3p FLT3 2.59289455139753 1.03200520972022e-21 -1.96802952624864 2.65981345780205e-05 PITA;miRanda;mirMAP;miRNATAP -0.189347699794977 0.0222763737551876 NA NA NA hsa-miR-491-5p FLT3LG 0.615770352820862 0.0418295628761654 -0.470988803938591 0.0537610955077815 miRanda -0.119840680493133 0.00424846672478406 NA NA NA hsa-miR-331-3p FLT4 2.28379581858927 1.99663919173155e-18 -0.514633942951051 0.0469674197809773 miRNAWalker2_validate -0.146482440615543 0.0015099115945375 NA NA NA hsa-let-7g-5p FN1 1.20061455355116 1.50237505511483e-12 -0.407678263046535 0.457934813442308 miRTarBase -1.38356947455025 6.70079108156719e-21 NA NA NA hsa-miR-144-3p FN1 0.658119849508907 0.146943823997989 -0.407678263046535 0.457934813442308 MirTarget -0.258927409565794 1.57328800578319e-05 NA NA NA hsa-miR-16-1-3p FN1 2.56983217111073 3.02262181237943e-20 -0.407678263046535 0.457934813442308 mirMAP -0.597286521474049 7.38498382250215e-11 NA NA NA hsa-miR-200b-3p FN1 3.78235093249346 3.18343003239465e-14 -0.407678263046535 0.457934813442308 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.597950765256644 8.42251389081856e-37 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-200c-3p FN1 3.50132673580082 2.42716349086937e-15 -0.407678263046535 0.457934813442308 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.661896693895972 1.64136219365611e-35 NA NA NA hsa-miR-26b-5p FN1 0.885393662798425 3.2116297961629e-06 -0.407678263046535 0.457934813442308 miRNAWalker2_validate -0.740291554820262 8.1789709477057e-08 NA NA NA hsa-miR-320a FN1 0.438165828017084 0.0390159073347133 -0.407678263046535 0.457934813442308 miRanda -1.04887566508125 5.02520748419077e-18 NA NA NA hsa-miR-320b FN1 1.55692969039548 1.41071034251915e-08 -0.407678263046535 0.457934813442308 miRanda -0.665480016494431 8.28719779629859e-13 NA NA NA hsa-miR-33a-3p FN1 1.72765312072219 1.51784443453521e-07 -0.407678263046535 0.457934813442308 mirMAP -0.720834465038679 1.19719425524499e-17 NA NA NA hsa-miR-429 FN1 4.48815175680773 2.44117492218206e-17 -0.407678263046535 0.457934813442308 MirTarget;PITA;miRanda;miRNATAP -0.526813403701254 2.58194150524164e-32 NA NA NA hsa-miR-590-3p FN1 2.59289455139753 1.03200520972022e-21 -0.407678263046535 0.457934813442308 miRanda;mirMAP -0.45878049547859 1.42151771675085e-06 NA NA NA hsa-miR-944 FN1 2.91186649218281 1.31574753528144e-06 -0.407678263046535 0.457934813442308 mirMAP -0.355794699553882 2.37688541107665e-16 NA NA NA hsa-miR-96-5p FN1 4.89433085814374 1.92000659886961e-31 -0.407678263046535 0.457934813442308 MirTarget;TargetScan -0.450514787117358 1.193321368228e-14 NA NA NA hsa-miR-103a-3p FOXO3 1.44083190496858 1.53799939616416e-13 -0.737333351162579 2.89864106254485e-06 mirMAP -0.167787619545507 1.24082040977403e-05 NA NA NA hsa-miR-107 FOXO3 1.30977326593435 1.30372468603965e-11 -0.737333351162579 2.89864106254485e-06 miRanda;mirMAP -0.12729515129698 0.00113749548397967 NA NA NA hsa-miR-126-5p FOXO3 0.895338176458417 2.33372756450713e-05 -0.737333351162579 2.89864106254485e-06 mirMAP -0.167977059725852 3.13543147619716e-06 NA NA NA hsa-miR-130a-3p FOXO3 2.02021855058359 1.26427102520415e-11 -0.737333351162579 2.89864106254485e-06 mirMAP -0.120947201392744 1.26550586819962e-06 NA NA NA hsa-miR-130b-3p FOXO3 3.5350292994509 1.73934183852569e-27 -0.737333351162579 2.89864106254485e-06 mirMAP -0.14492367565927 2.23910250382016e-11 NA NA NA hsa-miR-130b-5p FOXO3 2.9963110846538 1.98883029416455e-18 -0.737333351162579 2.89864106254485e-06 mirMAP;miRNATAP -0.132166174598728 1.26190102848863e-09 NA NA NA hsa-miR-140-3p FOXO3 0.0608890720479334 0.727716871248724 -0.737333351162579 2.89864106254485e-06 miRNATAP -0.148478507942181 0.000879017860797852 NA NA NA hsa-miR-188-5p FOXO3 2.52825126596644 6.78099435999778e-14 -0.737333351162579 2.89864106254485e-06 mirMAP -0.122102874060046 1.60582469086229e-07 NA NA NA hsa-miR-197-3p FOXO3 1.75733174019505 8.88576793100499e-13 -0.737333351162579 2.89864106254485e-06 miRNAWalker2_validate -0.165581262204659 4.03252468182204e-08 NA NA NA hsa-miR-26a-5p FOXO3 0.0464832722967259 0.752628386912329 -0.737333351162579 2.89864106254485e-06 miRNAWalker2_validate -0.11395224142875 0.0334137416144423 NA NA NA hsa-miR-28-5p FOXO3 0.230152919654905 0.0742909586754846 -0.737333351162579 2.89864106254485e-06 PITA;miRNATAP -0.244018972870857 6.85522540507652e-05 NA NA NA hsa-miR-29a-5p FOXO3 1.46749674755271 3.34605004270294e-07 -0.737333351162579 2.89864106254485e-06 mirMAP -0.121745038660313 1.18617942303428e-05 NA NA NA hsa-miR-29b-3p FOXO3 1.65828197923813 1.02676780888141e-09 -0.737333351162579 2.89864106254485e-06 miRNATAP -0.198846382345534 2.19060028440126e-13 NA NA NA hsa-miR-29c-3p FOXO3 -0.00968972577705429 0.97099586346872 -0.737333351162579 2.89864106254485e-06 miRNATAP -0.119627128313719 3.39093200847144e-05 NA NA NA hsa-miR-301a-3p FOXO3 2.81024345929638 2.29784847962242e-17 -0.737333351162579 2.89864106254485e-06 mirMAP -0.141326072877989 1.09614411747119e-09 NA NA NA hsa-miR-30c-5p FOXO3 0.778774633108 0.000285599212429136 -0.737333351162579 2.89864106254485e-06 miRNATAP -0.193506266192757 4.78743834590584e-08 NA NA NA hsa-miR-32-3p FOXO3 2.02436999565685 5.94091197945307e-09 -0.737333351162579 2.89864106254485e-06 mirMAP -0.133968693890663 4.37426831737266e-08 NA NA NA hsa-miR-330-3p FOXO3 0.876747334239085 0.00073709016089703 -0.737333351162579 2.89864106254485e-06 miRNATAP -0.103560135979176 0.000448445381298842 NA NA NA hsa-miR-361-3p FOXO3 1.07367425434318 1.73142774168958e-09 -0.737333351162579 2.89864106254485e-06 miRNATAP -0.206629780778379 1.15270770986054e-06 NA NA NA hsa-miR-362-3p FOXO3 2.0756816987665 3.89026064579331e-12 -0.737333351162579 2.89864106254485e-06 miRanda -0.158946970375523 4.38553514586577e-10 NA NA NA hsa-miR-450b-5p FOXO3 1.69244418548325 1.68064054148881e-10 -0.737333351162579 2.89864106254485e-06 miRNATAP -0.112558857944621 7.24134056500005e-05 NA NA NA hsa-miR-454-3p FOXO3 2.47234127820054 1.12878018736016e-21 -0.737333351162579 2.89864106254485e-06 mirMAP -0.173529447891059 1.43381624632046e-09 NA NA NA hsa-miR-542-3p FOXO3 1.18832665895751 1.98700670691565e-07 -0.737333351162579 2.89864106254485e-06 miRNATAP -0.118410920918723 0.000378410411785574 NA NA NA hsa-miR-576-5p FOXO3 2.20467023993664 3.4053475193793e-19 -0.737333351162579 2.89864106254485e-06 mirMAP -0.167246272268906 1.58516110437858e-08 NA NA NA hsa-miR-590-3p FOXO3 2.59289455139753 1.03200520972022e-21 -0.737333351162579 2.89864106254485e-06 PITA;miRanda;mirMAP;miRNATAP -0.157738739732064 8.569887853957e-09 NA NA NA hsa-miR-590-5p FOXO3 3.18300989862077 2.06813568597893e-26 -0.737333351162579 2.89864106254485e-06 miRanda -0.16417896315115 1.35896965138141e-11 NA NA NA hsa-miR-664a-3p FOXO3 0.634721925861133 0.00520070178640421 -0.737333351162579 2.89864106254485e-06 mirMAP -0.170551308607223 3.9761478730502e-07 NA NA NA hsa-miR-744-5p FOXO3 1.48254348878737 3.23019501613577e-09 -0.737333351162579 2.89864106254485e-06 miRNAWalker2_validate -0.103168012882185 0.000637623396015478 NA NA NA hsa-miR-92a-3p FOXO3 2.06460102658973 1.44784291084757e-19 -0.737333351162579 2.89864106254485e-06 mirMAP -0.144154020304602 7.42363265489457e-06 NA NA NA hsa-miR-93-3p FOXO3 2.85383869771942 5.64481766902125e-23 -0.737333351162579 2.89864106254485e-06 miRNATAP -0.148577484633802 2.17968159432128e-09 NA NA NA hsa-let-7a-5p GHR 0.618599506841644 2.76973453058748e-05 -3.38492582906153 8.02448227205103e-15 TargetScan;miRNATAP -0.489851683553939 0.00106341423193965 NA NA NA hsa-let-7b-5p GHR 0.604314269683977 0.00140009936153214 -3.38492582906153 8.02448227205103e-15 miRNATAP -0.374234097857817 0.00125741607753096 NA NA NA hsa-let-7e-5p GHR 0.860104282510173 6.04758298373779e-05 -3.38492582906153 8.02448227205103e-15 miRNATAP -0.350103011947092 0.000563515090589899 NA NA NA hsa-let-7f-5p GHR 0.495648727272215 0.00355972741198794 -3.38492582906153 8.02448227205103e-15 miRNATAP -0.44040158134168 0.00068069286302874 NA NA NA hsa-let-7g-5p GHR 1.20061455355116 1.50237505511483e-12 -3.38492582906153 8.02448227205103e-15 miRNATAP -0.989338476591974 7.89193758898709e-16 NA NA NA hsa-miR-126-5p GHR 0.895338176458417 2.33372756450713e-05 -3.38492582906153 8.02448227205103e-15 MirTarget;mirMAP -0.211480443669357 0.0405425003729238 NA NA NA hsa-miR-142-3p GHR 2.75247908790621 1.45636065474764e-12 -3.38492582906153 8.02448227205103e-15 MirTarget;PITA;miRanda;miRNATAP -0.163399868827137 0.00271425541508256 NA NA NA hsa-miR-15a-5p GHR 2.34669284378787 1.69544424500258e-23 -3.38492582906153 8.02448227205103e-15 MirTarget;miRNATAP -0.725130632734417 1.45411770458954e-17 NA NA NA hsa-miR-15b-5p GHR 1.57112623124278 9.14247846750597e-13 -3.38492582906153 8.02448227205103e-15 MirTarget;miRNATAP -0.775340036501137 1.33519810378816e-16 NA NA NA hsa-miR-16-2-3p GHR 2.31623086727196 4.29838149388188e-20 -3.38492582906153 8.02448227205103e-15 mirMAP -0.681238766716628 1.30028462785214e-17 NA NA NA hsa-miR-16-5p GHR 1.75824877145857 1.68592440033108e-16 -3.38492582906153 8.02448227205103e-15 MirTarget;miRNATAP -0.877331601703521 2.25054067493016e-20 NA NA NA hsa-miR-29a-5p GHR 1.46749674755271 3.34605004270294e-07 -3.38492582906153 8.02448227205103e-15 mirMAP;miRNATAP -0.398759363404256 3.8065582362983e-07 NA NA NA hsa-miR-3065-5p GHR 2.74629919868982 1.86846589298284e-08 -3.38492582906153 8.02448227205103e-15 MirTarget -0.234228533973949 1.16976592970447e-05 NA NA NA hsa-miR-33a-3p GHR 1.72765312072219 1.51784443453521e-07 -3.38492582906153 8.02448227205103e-15 miRNATAP -0.439955945280007 4.68048373449322e-10 NA NA NA hsa-miR-3607-3p GHR 2.68532138541128 5.66716351955047e-14 -3.38492582906153 8.02448227205103e-15 mirMAP -0.401827059830289 1.40697928073205e-11 NA NA NA hsa-miR-361-5p GHR 0.971859117235239 5.30236555707088e-09 -3.38492582906153 8.02448227205103e-15 miRanda -0.907977785941464 1.08517830269139e-12 NA NA NA hsa-miR-421 GHR 1.17791565395543 6.78526676976629e-06 -3.38492582906153 8.02448227205103e-15 miRanda -0.407158287477524 7.31048308168014e-07 NA NA NA hsa-miR-424-5p GHR 1.61930224569578 1.89642549274994e-10 -3.38492582906153 8.02448227205103e-15 MirTarget;miRNATAP -0.375073088269749 7.4050786109638e-06 NA NA NA hsa-miR-429 GHR 4.48815175680773 2.44117492218206e-17 -3.38492582906153 8.02448227205103e-15 miRanda;miRNATAP -0.353072088127256 6.98086999082263e-21 NA NA NA hsa-miR-455-5p GHR 2.2582442061694 1.43472128037398e-13 -3.38492582906153 8.02448227205103e-15 miRanda -0.288005479017098 2.99968917323832e-05 NA NA NA hsa-miR-491-5p GHR 0.615770352820862 0.0418295628761654 -3.38492582906153 8.02448227205103e-15 miRanda -0.252112855528744 0.00110544469002084 NA NA NA hsa-miR-590-3p GHR 2.59289455139753 1.03200520972022e-21 -3.38492582906153 8.02448227205103e-15 mirMAP -0.634448400274296 7.47892324972576e-17 NA NA NA hsa-miR-624-5p GHR 1.47043111118159 8.25080691741182e-09 -3.38492582906153 8.02448227205103e-15 MirTarget -0.346198820430003 7.24372283956265e-05 NA NA NA hsa-miR-651-5p GHR 2.32951837918862 1.62508965949028e-11 -3.38492582906153 8.02448227205103e-15 MirTarget -0.413836991843524 1.26883217498809e-09 NA NA NA hsa-miR-7-1-3p GHR 1.84950311431067 1.25300363397654e-13 -3.38492582906153 8.02448227205103e-15 MirTarget;mirMAP -0.615754978567405 1.07102766811281e-13 NA NA NA hsa-miR-944 GHR 2.91186649218281 1.31574753528144e-06 -3.38492582906153 8.02448227205103e-15 MirTarget;PITA;mirMAP -0.271318533457072 3.74851354788153e-14 NA NA NA hsa-miR-101-3p GNB1 0.522819989585461 0.00375627731618038 0.0801691781103262 0.384843432128372 miRNAWalker2_validate;MirTarget;miRNATAP -0.13589850334445 2.52565267772536e-08 NA NA NA hsa-miR-26b-5p GNB3 0.885393662798425 3.2116297961629e-06 -0.199536406532463 0.575145671410422 miRNAWalker2_validate -0.187497955295634 0.0387550135415387 NA NA NA hsa-miR-320a GNB3 0.438165828017084 0.0390159073347133 -0.199536406532463 0.575145671410422 miRanda -0.191998455100168 0.0188752648802213 NA NA NA hsa-miR-330-5p GNB3 1.15100069700871 4.85551805046014e-07 -0.199536406532463 0.575145671410422 miRanda -0.16268442933353 0.0297312550931069 NA NA NA hsa-miR-103a-2-5p GNB4 2.47599305985086 7.933028987326e-11 -0.637235835846949 0.0637787413436148 MirTarget -0.208044825181209 1.48817111909234e-05 NA NA NA hsa-miR-186-5p GNB4 1.47445398888668 3.0781726595413e-15 -0.637235835846949 0.0637787413436148 MirTarget -0.425008340793968 8.11370178730736e-07 NA NA NA hsa-miR-203a-3p GNB4 3.12352008343999 9.49391438647189e-07 -0.637235835846949 0.0637787413436148 MirTarget -0.111293242469192 1.31643864940443e-05 NA NA NA hsa-miR-23b-3p GNB4 -0.251132426825047 0.150200321210792 -0.637235835846949 0.0637787413436148 mirMAP -0.432382465446317 6.85322291224931e-06 NA NA NA hsa-miR-29b-3p GNB4 1.65828197923813 1.02676780888141e-09 -0.637235835846949 0.0637787413436148 MirTarget -0.237099869786872 7.67615650269402e-05 NA NA NA hsa-miR-29c-3p GNB4 -0.00968972577705429 0.97099586346872 -0.637235835846949 0.0637787413436148 miRNAWalker2_validate;MirTarget -0.533878931428651 7.81676803580413e-19 NA NA NA hsa-miR-3065-5p GNB4 2.74629919868982 1.86846589298284e-08 -0.637235835846949 0.0637787413436148 mirMAP -0.120245985176494 0.00337512624646212 NA NA NA hsa-miR-33a-3p GNB4 1.72765312072219 1.51784443453521e-07 -0.637235835846949 0.0637787413436148 MirTarget -0.416797676785028 4.54650746681482e-15 NA NA NA hsa-miR-361-5p GNB4 0.971859117235239 5.30236555707088e-09 -0.637235835846949 0.0637787413436148 miRanda;miRNATAP -0.711788578839117 2.31916622157804e-13 NA NA NA hsa-miR-429 GNB4 4.48815175680773 2.44117492218206e-17 -0.637235835846949 0.0637787413436148 miRanda -0.35802227541613 6.09495863227166e-39 NA NA NA hsa-miR-501-5p GNB4 1.93654809410041 1.3779381780759e-10 -0.637235835846949 0.0637787413436148 mirMAP -0.244167840839471 9.96965162188072e-06 NA NA NA hsa-miR-582-5p GNB4 0.609226359812689 0.032988717891497 -0.637235835846949 0.0637787413436148 MirTarget -0.355773912086893 5.28055893795784e-10 NA NA NA hsa-miR-877-5p GNB4 2.94916202082736 1.8151927276044e-13 -0.637235835846949 0.0637787413436148 MirTarget -0.26024285659458 6.14734036375707e-09 NA NA NA hsa-miR-93-5p GNB4 3.03961860136032 1.11672209617395e-24 -0.637235835846949 0.0637787413436148 miRNAWalker2_validate -0.46591844935709 4.02316238221017e-20 NA NA NA hsa-miR-96-5p GNB4 4.89433085814374 1.92000659886961e-31 -0.637235835846949 0.0637787413436148 MirTarget -0.338685707733092 4.78652097617994e-21 NA NA NA hsa-miR-128-3p GNB5 1.63756041666078 6.79626586407187e-14 -0.839186629235185 5.42372549345636e-07 miRNAWalker2_validate -0.213252596980441 3.20411533204574e-09 NA NA NA hsa-miR-130b-3p GNB5 3.5350292994509 1.73934183852569e-27 -0.839186629235185 5.42372549345636e-07 miRNAWalker2_validate -0.156991330989953 9.70422622073259e-12 NA NA NA hsa-miR-17-5p GNB5 3.2710598467455 9.93128340539455e-27 -0.839186629235185 5.42372549345636e-07 TargetScan -0.157422525493657 1.81637594978173e-10 NA NA NA hsa-miR-26b-5p GNB5 0.885393662798425 3.2116297961629e-06 -0.839186629235185 5.42372549345636e-07 miRNAWalker2_validate -0.136961383665604 0.00146595434447694 NA NA NA hsa-miR-338-3p GNB5 0.453166438193782 0.144583389707558 -0.839186629235185 5.42372549345636e-07 miRanda -0.112890802011661 1.71063885448933e-05 NA NA NA hsa-miR-342-3p GNB5 1.49115144672245 1.43879249744621e-07 -0.839186629235185 5.42372549345636e-07 miRanda -0.134199633314021 2.13157413029708e-06 NA NA NA hsa-miR-361-5p GNB5 0.971859117235239 5.30236555707088e-09 -0.839186629235185 5.42372549345636e-07 miRanda -0.243716514423257 5.35175739330283e-07 NA NA NA hsa-miR-425-5p GNB5 3.07071373939774 4.02947460586085e-25 -0.839186629235185 5.42372549345636e-07 miRNAWalker2_validate -0.190730698510053 4.96622354891869e-14 NA NA NA hsa-miR-542-3p GNB5 1.18832665895751 1.98700670691565e-07 -0.839186629235185 5.42372549345636e-07 miRanda -0.170586839558852 1.30397148341979e-06 NA NA NA hsa-miR-590-3p GNB5 2.59289455139753 1.03200520972022e-21 -0.839186629235185 5.42372549345636e-07 miRanda -0.156055107257856 9.65303604312259e-08 NA NA NA hsa-miR-320a GNG11 0.438165828017084 0.0390159073347133 -2.05664853112334 2.60910520564216e-14 miRanda -0.202155625710573 0.00157136796729667 NA NA NA hsa-miR-320b GNG11 1.55692969039548 1.41071034251915e-08 -2.05664853112334 2.60910520564216e-14 miRanda -0.330998429874158 2.5949257931811e-12 NA NA NA hsa-miR-330-5p GNG11 1.15100069700871 4.85551805046014e-07 -2.05664853112334 2.60910520564216e-14 miRanda -0.277412112888266 1.77285723228506e-06 NA NA NA hsa-miR-107 GNG12 1.30977326593435 1.30372468603965e-11 -1.00694431810149 1.61985728260734e-06 miRanda -0.325194911035192 2.35617021655576e-10 NA NA NA hsa-miR-126-5p GNG12 0.895338176458417 2.33372756450713e-05 -1.00694431810149 1.61985728260734e-06 mirMAP -0.216265925507577 7.06592392108692e-06 NA NA NA hsa-miR-140-5p GNG12 0.844753502512594 3.73722278438606e-05 -1.00694431810149 1.61985728260734e-06 PITA;miRanda -0.215923167393918 1.48186394256009e-05 NA NA NA hsa-miR-186-5p GNG12 1.47445398888668 3.0781726595413e-15 -1.00694431810149 1.61985728260734e-06 miRNAWalker2_validate -0.290324396097542 4.28690446751612e-08 NA NA NA hsa-miR-28-5p GNG12 0.230152919654905 0.0742909586754846 -1.00694431810149 1.61985728260734e-06 PITA;miRanda -0.199366829360215 0.0154269432421396 NA NA NA hsa-miR-30d-3p GNG12 0.977747550180601 4.3048212205381e-05 -1.00694431810149 1.61985728260734e-06 mirMAP -0.268445146648906 1.78296007701357e-10 NA NA NA hsa-miR-30e-3p GNG12 -0.215663037684509 0.235375122783546 -1.00694431810149 1.61985728260734e-06 mirMAP -0.232213452778567 4.65209274857153e-05 NA NA NA hsa-miR-374a-5p GNG12 0.484615721953736 0.0042981729815149 -1.00694431810149 1.61985728260734e-06 mirMAP -0.213351975656957 0.000483455395337009 NA NA NA hsa-miR-374b-5p GNG12 0.0654362503857184 0.722673188879465 -1.00694431810149 1.61985728260734e-06 mirMAP -0.117656651462575 0.0377316143150431 NA NA NA hsa-miR-409-5p GNG12 1.56949123847358 5.91654175754272e-07 -1.00694431810149 1.61985728260734e-06 PITA -0.165828998572686 9.83801581754514e-07 NA NA NA hsa-miR-423-5p GNG12 0.963563145758616 9.86109015204915e-07 -1.00694431810149 1.61985728260734e-06 miRNAWalker2_validate -0.340366952806888 2.37757447594555e-11 NA NA NA hsa-miR-429 GNG12 4.48815175680773 2.44117492218206e-17 -1.00694431810149 1.61985728260734e-06 miRanda -0.161475795423235 1.09474596004218e-19 NA NA NA hsa-miR-508-3p GNG12 1.05493034310846 0.0393857095042515 -1.00694431810149 1.61985728260734e-06 mirMAP -0.109947026301814 5.08686689387732e-08 NA NA NA hsa-miR-542-3p GNG12 1.18832665895751 1.98700670691565e-07 -1.00694431810149 1.61985728260734e-06 miRanda -0.168110144177005 0.000154291626655441 NA NA NA hsa-miR-590-3p GNG12 2.59289455139753 1.03200520972022e-21 -1.00694431810149 1.61985728260734e-06 miRanda;mirMAP -0.204473638976492 2.35752221652166e-08 NA NA NA hsa-miR-590-5p GNG12 3.18300989862077 2.06813568597893e-26 -1.00694431810149 1.61985728260734e-06 PITA -0.219549663318668 1.24972971345505e-11 NA NA NA hsa-miR-96-5p GNG12 4.89433085814374 1.92000659886961e-31 -1.00694431810149 1.61985728260734e-06 TargetScan -0.203127178908812 7.44354635001805e-20 NA NA NA hsa-miR-181c-5p GNG2 1.58587920618301 1.57506918816933e-10 -1.3576212262363 2.04502229623169e-05 miRNATAP -0.21465028336591 0.000485266762019858 NA NA NA hsa-miR-23a-3p GNG2 1.00493340843378 2.55313889288924e-08 -1.3576212262363 2.04502229623169e-05 miRNATAP -0.31584441982254 0.000227079160987913 NA NA NA hsa-miR-23b-3p GNG2 -0.251132426825047 0.150200321210792 -1.3576212262363 2.04502229623169e-05 miRNATAP -0.385954021469517 1.79074816028985e-05 NA NA NA hsa-miR-28-5p GNG2 0.230152919654905 0.0742909586754846 -1.3576212262363 2.04502229623169e-05 miRanda;miRNATAP -0.393158661465059 0.00157741925316573 NA NA NA hsa-miR-29b-3p GNG2 1.65828197923813 1.02676780888141e-09 -1.3576212262363 2.04502229623169e-05 miRNATAP -0.214697013701517 0.000129615129388853 NA NA NA hsa-miR-29c-3p GNG2 -0.00968972577705429 0.97099586346872 -1.3576212262363 2.04502229623169e-05 miRNATAP -0.29316634790736 4.49460145833738e-07 NA NA NA hsa-miR-3065-5p GNG2 2.74629919868982 1.86846589298284e-08 -1.3576212262363 2.04502229623169e-05 mirMAP;miRNATAP -0.19253828440026 3.96508273392714e-07 NA NA NA hsa-miR-30d-3p GNG2 0.977747550180601 4.3048212205381e-05 -1.3576212262363 2.04502229623169e-05 mirMAP -0.513300020225803 3.01900186843667e-16 NA NA NA hsa-miR-30e-3p GNG2 -0.215663037684509 0.235375122783546 -1.3576212262363 2.04502229623169e-05 mirMAP -0.405914477167732 2.43350600762805e-06 NA NA NA hsa-miR-324-5p GNG2 2.95683728155095 1.32960514360912e-20 -1.3576212262363 2.04502229623169e-05 miRanda -0.293763157441407 1.41347118146231e-10 NA NA NA hsa-miR-330-5p GNG2 1.15100069700871 4.85551805046014e-07 -1.3576212262363 2.04502229623169e-05 miRanda -0.286226496141626 2.02806491054351e-05 NA NA NA hsa-miR-335-3p GNG2 3.08791651139852 5.31309869723517e-12 -1.3576212262363 2.04502229623169e-05 mirMAP -0.204524138879155 7.32871063541175e-10 NA NA NA hsa-miR-429 GNG2 4.48815175680773 2.44117492218206e-17 -1.3576212262363 2.04502229623169e-05 miRanda;miRNATAP -0.331914241042916 3.62710052422193e-38 NA NA NA hsa-miR-576-5p GNG2 2.20467023993664 3.4053475193793e-19 -1.3576212262363 2.04502229623169e-05 mirMAP -0.257529688449422 1.9736249431505e-05 NA NA NA hsa-miR-590-3p GNG2 2.59289455139753 1.03200520972022e-21 -1.3576212262363 2.04502229623169e-05 PITA;miRanda;mirMAP;miRNATAP -0.166031330399532 0.00314938774617366 NA NA NA hsa-miR-590-5p GNG2 3.18300989862077 2.06813568597893e-26 -1.3576212262363 2.04502229623169e-05 miRanda;miRNATAP -0.251863772930653 4.00935454984172e-07 NA NA NA hsa-miR-944 GNG2 2.91186649218281 1.31574753528144e-06 -1.3576212262363 2.04502229623169e-05 mirMAP -0.233642534231636 1.50210162128137e-20 NA NA NA hsa-miR-141-3p GNG4 5.02396127982626 2.19224509139725e-24 0.216159437363437 0.744682539041036 mirMAP -0.31409320803834 2.17335380219881e-07 NA NA NA hsa-miR-200a-3p GNG4 4.59434485520731 6.38952518573476e-18 0.216159437363437 0.744682539041036 mirMAP -0.332232611120332 4.81558966773253e-09 NA NA NA hsa-miR-200b-3p GNG4 3.78235093249346 3.18343003239465e-14 0.216159437363437 0.744682539041036 mirMAP -0.36236807268835 3.2889821314364e-09 NA NA NA hsa-miR-200c-3p GNG4 3.50132673580082 2.42716349086937e-15 0.216159437363437 0.744682539041036 mirMAP -0.415747931208297 1.50663821120222e-09 NA NA NA hsa-miR-23b-3p GNG4 -0.251132426825047 0.150200321210792 0.216159437363437 0.744682539041036 mirMAP -0.422052606711545 0.024014032409438 NA NA NA hsa-miR-3913-5p GNG4 2.44353493655328 8.95279496632448e-15 0.216159437363437 0.744682539041036 mirMAP -0.440853203267675 1.24030418788711e-05 NA NA NA hsa-miR-429 GNG4 4.48815175680773 2.44117492218206e-17 0.216159437363437 0.744682539041036 mirMAP -0.299425628163015 1.80796068967457e-07 NA NA NA hsa-miR-940 GNG4 3.21011374578759 2.7923171128495e-14 0.216159437363437 0.744682539041036 MirTarget -0.178741920660736 0.0263798169682456 NA NA NA hsa-miR-1271-5p GNG7 0.970418832993172 0.000609742584380688 -3.47904747202308 1.83990532659951e-21 mirMAP -0.16947525495514 0.0100090271242922 NA NA NA hsa-miR-141-3p GNG7 5.02396127982626 2.19224509139725e-24 -3.47904747202308 1.83990532659951e-21 MirTarget;TargetScan;miRNATAP -0.30384219654589 5.18426669901378e-19 NA NA NA hsa-miR-17-3p GNG7 2.2704817679209 1.1667437320211e-22 -3.47904747202308 1.83990532659951e-21 mirMAP -0.684476176313002 7.68486674689711e-21 NA NA NA hsa-miR-181a-2-3p GNG7 2.19062681262366 3.81790102612782e-13 -3.47904747202308 1.83990532659951e-21 mirMAP -0.335669935644941 1.43374984371638e-08 NA NA NA hsa-miR-182-5p GNG7 3.53923166221814 5.07781258121574e-21 -3.47904747202308 1.83990532659951e-21 mirMAP -0.33394588120831 3.25159373659616e-13 NA NA NA hsa-miR-185-3p GNG7 2.3922478518806 1.3373426768452e-14 -3.47904747202308 1.83990532659951e-21 mirMAP -0.438607972404773 6.85525137484324e-15 NA NA NA hsa-miR-18a-3p GNG7 2.14813400940323 2.23460809936028e-06 -3.47904747202308 1.83990532659951e-21 mirMAP -0.35654455370598 9.55382918035363e-13 NA NA NA hsa-miR-18a-5p GNG7 3.78535678765353 3.72446596213886e-26 -3.47904747202308 1.83990532659951e-21 mirMAP -0.453466540974555 4.53012964759705e-20 NA NA NA hsa-miR-193b-5p GNG7 1.59567208918739 4.89398272459427e-08 -3.47904747202308 1.83990532659951e-21 mirMAP -0.510359949062033 3.3741341742903e-17 NA NA NA hsa-miR-1976 GNG7 2.06550563678192 7.81396978619772e-18 -3.47904747202308 1.83990532659951e-21 mirMAP -0.525455269718449 5.64587335164917e-13 NA NA NA hsa-miR-200a-3p GNG7 4.59434485520731 6.38952518573476e-18 -3.47904747202308 1.83990532659951e-21 MirTarget;miRNATAP -0.217504146423653 3.11251108490255e-11 NA NA NA hsa-miR-22-3p GNG7 1.21545661147757 1.61670170137775e-13 -3.47904747202308 1.83990532659951e-21 mirMAP -0.388779813370745 0.000472338496755928 NA NA NA hsa-miR-22-5p GNG7 1.88011544159252 1.63978222572222e-16 -3.47904747202308 1.83990532659951e-21 mirMAP -0.376456368932511 1.58429041782012e-06 NA NA NA hsa-miR-224-5p GNG7 2.94107125335675 5.72194099515157e-08 -3.47904747202308 1.83990532659951e-21 mirMAP -0.213933941333942 9.91359689545342e-11 NA NA NA hsa-miR-23a-3p GNG7 1.00493340843378 2.55313889288924e-08 -3.47904747202308 1.83990532659951e-21 mirMAP -0.798801855523738 1.00550050246051e-15 NA NA NA hsa-miR-29b-3p GNG7 1.65828197923813 1.02676780888141e-09 -3.47904747202308 1.83990532659951e-21 mirMAP -0.152957593981507 0.0234761526446955 NA NA NA hsa-miR-30b-3p GNG7 0.834142820354026 0.000972582820878813 -3.47904747202308 1.83990532659951e-21 MirTarget -0.157420881937103 0.0336984459791354 NA NA NA hsa-miR-31-3p GNG7 2.70807981248858 8.84479434501203e-05 -3.47904747202308 1.83990532659951e-21 mirMAP -0.177163720921599 8.88786109564702e-10 NA NA NA hsa-miR-31-5p GNG7 3.59165123035072 2.27423212057482e-07 -3.47904747202308 1.83990532659951e-21 mirMAP -0.198201946727868 3.73578574505353e-13 NA NA NA hsa-miR-3127-5p GNG7 1.51846438737133 3.59571251672767e-07 -3.47904747202308 1.83990532659951e-21 mirMAP -0.280682611037895 4.52736303278137e-06 NA NA NA hsa-miR-330-5p GNG7 1.15100069700871 4.85551805046014e-07 -3.47904747202308 1.83990532659951e-21 mirMAP -0.386056825779043 1.45376282981714e-06 NA NA NA hsa-miR-3614-5p GNG7 2.17736331059655 2.19144831318484e-08 -3.47904747202308 1.83990532659951e-21 mirMAP -0.29266188230583 9.94205791272714e-10 NA NA NA hsa-miR-3615 GNG7 2.22631608637736 1.11307777062266e-16 -3.47904747202308 1.83990532659951e-21 mirMAP -0.542864787918364 3.26053388101788e-16 NA NA NA hsa-miR-3913-5p GNG7 2.44353493655328 8.95279496632448e-15 -3.47904747202308 1.83990532659951e-21 mirMAP -0.18866018319481 0.00134615525889515 NA NA NA hsa-miR-500a-3p GNG7 1.47161373123699 5.30571342631915e-09 -3.47904747202308 1.83990532659951e-21 mirMAP -0.26612311178083 0.000247224078153993 NA NA NA hsa-miR-532-3p GNG7 1.96631878320218 4.53421954361695e-13 -3.47904747202308 1.83990532659951e-21 mirMAP -0.432788752985029 3.68415403004414e-11 NA NA NA hsa-miR-590-3p GNG7 2.59289455139753 1.03200520972022e-21 -3.47904747202308 1.83990532659951e-21 PITA;miRanda;mirMAP -0.533820994714737 2.21837557375079e-16 NA NA NA hsa-miR-671-5p GNG7 2.97733652243246 1.21148452344738e-23 -3.47904747202308 1.83990532659951e-21 mirMAP -0.508975052093562 4.0726461912807e-17 NA NA NA hsa-miR-766-3p GNG7 1.2456012547833 6.44584025471128e-06 -3.47904747202308 1.83990532659951e-21 MirTarget -0.28089398115972 2.44037562044379e-05 NA NA NA hsa-miR-92a-3p GNG7 2.06460102658973 1.44784291084757e-19 -3.47904747202308 1.83990532659951e-21 miRNAWalker2_validate -0.716653835819047 8.40156233472874e-22 NA NA NA hsa-miR-940 GNG7 3.21011374578759 2.7923171128495e-14 -3.47904747202308 1.83990532659951e-21 MirTarget -0.340249290712474 6.0759666731278e-14 NA NA NA hsa-miR-96-5p GNG7 4.89433085814374 1.92000659886961e-31 -3.47904747202308 1.83990532659951e-21 mirMAP -0.346426590246556 1.50679346630299e-17 NA NA NA hsa-miR-146b-5p GNGT1 1.75587235896724 1.15724631266659e-07 1.18732621895826 0.00917845257646314 miRanda -0.162073068012436 0.0138848442779443 NA NA NA hsa-miR-2110 GNGT2 1.16625590651194 6.4784195289885e-05 -0.202884200576091 0.562224213234923 miRNATAP -0.216445830254323 0.000460270527773238 NA NA NA hsa-miR-219a-1-3p GNGT2 1.14752647140971 0.00048791524196346 -0.202884200576091 0.562224213234923 MirTarget -0.443679432298624 2.24756675612032e-15 NA NA NA hsa-miR-335-5p GNGT2 1.77247705492746 2.22457658872091e-06 -0.202884200576091 0.562224213234923 miRNAWalker2_validate -0.150080296455862 0.000750747471335338 NA NA NA hsa-miR-320a GRB2 0.438165828017084 0.0390159073347133 0.0788721517658564 0.390920910556044 MirTarget;miRanda;mirMAP;miRNATAP -0.105017257701224 3.72382950677321e-07 NA NA NA hsa-miR-139-5p GSK3B -1.52606598644743 1.20474151350665e-08 0.406268283461383 0.000508906658360755 mirMAP -0.100160771461377 1.20519675407331e-06 NA NA NA hsa-let-7a-3p HGF 1.42015538786275 7.03375209382654e-13 -2.96833708580794 2.21214820634191e-07 mirMAP -0.542810606112975 9.43474905006386e-05 NA NA NA hsa-let-7b-3p HGF 0.868207752019623 1.30460056774366e-05 -2.96833708580794 2.21214820634191e-07 mirMAP -0.566084083307672 5.71312900566914e-05 NA NA NA hsa-let-7f-1-3p HGF 1.55054488387679 7.31326775537952e-11 -2.96833708580794 2.21214820634191e-07 mirMAP -0.343222022733725 0.00407354838842982 NA NA NA hsa-miR-126-5p HGF 0.895338176458417 2.33372756450713e-05 -2.96833708580794 2.21214820634191e-07 mirMAP -0.30252476535825 0.0230197315111662 NA NA NA hsa-miR-129-5p HGF -0.524170159980738 0.222582956006346 -2.96833708580794 2.21214820634191e-07 mirMAP -0.176315710478523 0.00827877952568297 NA NA NA hsa-miR-141-3p HGF 5.02396127982626 2.19224509139725e-24 -2.96833708580794 2.21214820634191e-07 MirTarget;TargetScan -0.676636907580645 1.12497659260577e-44 NA NA NA hsa-miR-181a-5p HGF 2.29556023480783 1.8138457900616e-21 -2.96833708580794 2.21214820634191e-07 mirMAP -0.725020652043404 2.96259222943239e-11 NA NA NA hsa-miR-181b-5p HGF 2.49307679431293 3.92829250217627e-20 -2.96833708580794 2.21214820634191e-07 mirMAP -0.706743272553437 2.55576874895847e-13 NA NA NA hsa-miR-181c-5p HGF 1.58587920618301 1.57506918816933e-10 -2.96833708580794 2.21214820634191e-07 mirMAP -0.655855093153665 2.2633028663108e-09 NA NA NA hsa-miR-200a-3p HGF 4.59434485520731 6.38952518573476e-18 -2.96833708580794 2.21214820634191e-07 MirTarget -0.565686401356116 7.92905519776232e-34 NA NA NA hsa-miR-203a-3p HGF 3.12352008343999 9.49391438647189e-07 -2.96833708580794 2.21214820634191e-07 MirTarget -0.307285226038045 3.93961477705831e-13 NA NA NA hsa-miR-224-3p HGF 1.87536386559317 6.15140969394846e-05 -2.96833708580794 2.21214820634191e-07 mirMAP -0.425091238537773 2.95664734683986e-12 NA NA NA hsa-miR-26b-5p HGF 0.885393662798425 3.2116297961629e-06 -2.96833708580794 2.21214820634191e-07 MirTarget;miRNATAP -0.860917332821866 3.45908003051971e-09 NA NA NA hsa-miR-30b-5p HGF 0.800822374912712 0.000133601914525413 -2.96833708580794 2.21214820634191e-07 mirMAP -0.745493458613655 1.87319496040024e-08 NA NA NA hsa-miR-30c-5p HGF 0.778774633108 0.000285599212429136 -2.96833708580794 2.21214820634191e-07 mirMAP -0.865812342797699 1.59173376397441e-11 NA NA NA hsa-miR-30d-5p HGF 0.675423997639582 0.00270618816039773 -2.96833708580794 2.21214820634191e-07 mirMAP -1.14363195060416 9.73383073509946e-22 NA NA NA hsa-miR-30e-5p HGF 1.23904909539663 1.35561917122157e-09 -2.96833708580794 2.21214820634191e-07 mirMAP -1.43246567275328 1.85577963409756e-29 NA NA NA hsa-miR-335-3p HGF 3.08791651139852 5.31309869723517e-12 -2.96833708580794 2.21214820634191e-07 mirMAP -0.296203494255056 9.94228604078741e-07 NA NA NA hsa-miR-33a-3p HGF 1.72765312072219 1.51784443453521e-07 -2.96833708580794 2.21214820634191e-07 mirMAP -0.709152405531059 2.95855303843078e-15 NA NA NA hsa-miR-34c-5p HGF 2.07190852984647 7.35776320806257e-08 -2.96833708580794 2.21214820634191e-07 miRanda -0.179064697968714 0.0198975045718808 NA NA NA hsa-miR-421 HGF 1.17791565395543 6.78526676976629e-06 -2.96833708580794 2.21214820634191e-07 miRanda -0.423367559608824 7.10463304822239e-05 NA NA NA hsa-miR-429 HGF 4.48815175680773 2.44117492218206e-17 -2.96833708580794 2.21214820634191e-07 miRanda -0.520793016805242 9.95726908305676e-28 NA NA NA hsa-miR-582-5p HGF 0.609226359812689 0.032988717891497 -2.96833708580794 2.21214820634191e-07 PITA -0.41813369111985 1.98992264527824e-05 NA NA NA hsa-miR-590-3p HGF 2.59289455139753 1.03200520972022e-21 -2.96833708580794 2.21214820634191e-07 miRanda;mirMAP -0.643510815709232 1.09614685120259e-10 NA NA NA hsa-miR-590-5p HGF 3.18300989862077 2.06813568597893e-26 -2.96833708580794 2.21214820634191e-07 miRanda -0.712648418249155 4.67151690440208e-16 NA NA NA hsa-miR-651-5p HGF 2.32951837918862 1.62508965949028e-11 -2.96833708580794 2.21214820634191e-07 MirTarget -0.876408480048342 2.87757604471444e-25 NA NA NA hsa-miR-7-1-3p HGF 1.84950311431067 1.25300363397654e-13 -2.96833708580794 2.21214820634191e-07 mirMAP -0.580271470067749 8.96109537411397e-08 NA NA NA hsa-miR-944 HGF 2.91186649218281 1.31574753528144e-06 -2.96833708580794 2.21214820634191e-07 mirMAP -0.408051827291836 3.7779107870685e-19 NA NA NA hsa-miR-143-3p HRAS -2.5789192793377 1.55518999614836e-14 0.623195449314017 0.00175543589552248 miRNAWalker2_validate;miRTarBase -0.162589208332201 3.09270971499286e-09 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-30c-5p HSP90AA1 0.778774633108 0.000285599212429136 0.241311473799849 0.102101592663015 miRNAWalker2_validate -0.112013065733172 0.000730676400513086 NA NA NA hsa-miR-129-5p IBSP -0.524170159980738 0.222582956006346 3.42434031155439 3.07621992130546e-10 miRanda -0.194616074104651 0.00227802533253941 25344911 Using microarray and BSP Bisulfate Sequencing PCR assays we found that compared with the parent SGC7901/VCR cells expression of miR-129-5p was restored in SGC7901/VCR gastric cancer multi-drug resistant cell line treated by de-methylation reagent 5-AZA-dC gastric cancer hsa-miR-139-5p IBSP -1.52606598644743 1.20474151350665e-08 3.42434031155439 3.07621992130546e-10 miRanda -0.218224330411268 0.0279486051945519 NA NA NA hsa-let-7a-3p IGF1 1.42015538786275 7.03375209382654e-13 -3.75951127345565 1.26264890381366e-10 mirMAP -0.92426917804667 5.0725450948492e-11 NA NA NA hsa-let-7a-5p IGF1 0.618599506841644 2.76973453058748e-05 -3.75951127345565 1.26264890381366e-10 TargetScan -1.35484578107079 3.03432417502265e-12 NA NA NA hsa-let-7b-3p IGF1 0.868207752019623 1.30460056774366e-05 -3.75951127345565 1.26264890381366e-10 mirMAP -0.806527950481254 1.86996353532323e-08 NA NA NA hsa-let-7f-1-3p IGF1 1.55054488387679 7.31326775537952e-11 -3.75951127345565 1.26264890381366e-10 mirMAP -0.53583367534408 1.14955943868674e-05 NA NA NA hsa-miR-103a-2-5p IGF1 2.47599305985086 7.933028987326e-11 -3.75951127345565 1.26264890381366e-10 mirMAP -0.672288935268143 1.21134250789966e-16 NA NA NA hsa-miR-129-5p IGF1 -0.524170159980738 0.222582956006346 -3.75951127345565 1.26264890381366e-10 MirTarget;PITA;miRanda -0.24872412851026 0.000279350666200339 NA NA NA hsa-miR-130a-3p IGF1 2.02021855058359 1.26427102520415e-11 -3.75951127345565 1.26264890381366e-10 MirTarget -0.315325422858442 0.000861190344159203 NA NA NA hsa-miR-130b-3p IGF1 3.5350292994509 1.73934183852569e-27 -3.75951127345565 1.26264890381366e-10 MirTarget -0.781941096991651 4.63853079450254e-23 NA NA NA hsa-miR-148a-5p IGF1 1.16173838132242 0.000148929299881612 -3.75951127345565 1.26264890381366e-10 mirMAP -0.212992981754178 0.0236997428556886 NA NA NA hsa-miR-15b-3p IGF1 2.33847028227712 4.29662877950836e-19 -3.75951127345565 1.26264890381366e-10 mirMAP -1.14217010288885 5.28861971423639e-31 NA NA NA hsa-miR-16-1-3p IGF1 2.56983217111073 3.02262181237943e-20 -3.75951127345565 1.26264890381366e-10 mirMAP -0.921958602704484 2.5787665170735e-21 NA NA NA hsa-miR-181a-5p IGF1 2.29556023480783 1.8138457900616e-21 -3.75951127345565 1.26264890381366e-10 mirMAP -0.642043297035051 1.32592036628183e-08 NA NA NA hsa-miR-181b-5p IGF1 2.49307679431293 3.92829250217627e-20 -3.75951127345565 1.26264890381366e-10 mirMAP -0.697159274066391 2.64064192584975e-12 NA NA NA hsa-miR-181c-5p IGF1 1.58587920618301 1.57506918816933e-10 -3.75951127345565 1.26264890381366e-10 mirMAP -0.418006737238249 0.00025755851863695 NA NA NA hsa-miR-186-5p IGF1 1.47445398888668 3.0781726595413e-15 -3.75951127345565 1.26264890381366e-10 mirMAP -1.20504446214237 1.61828209547411e-16 NA NA NA hsa-miR-19a-3p IGF1 3.42309334186656 3.02671914353412e-28 -3.75951127345565 1.26264890381366e-10 MirTarget -0.788529625251502 2.31580352219079e-21 NA NA NA hsa-miR-19b-1-5p IGF1 2.57951428759379 4.31576118703427e-20 -3.75951127345565 1.26264890381366e-10 mirMAP -0.995592930242643 1.89907484758614e-25 NA NA NA hsa-miR-19b-3p IGF1 2.49529833021187 1.57028265846699e-23 -3.75951127345565 1.26264890381366e-10 MirTarget -1.0369004238185 3.24569264936101e-23 NA NA NA hsa-miR-20a-3p IGF1 2.92621109947706 2.49504904635375e-17 -3.75951127345565 1.26264890381366e-10 mirMAP -0.809636638775284 3.3899709447565e-25 NA NA NA hsa-miR-224-3p IGF1 1.87536386559317 6.15140969394846e-05 -3.75951127345565 1.26264890381366e-10 mirMAP -0.362328718988192 1.01049263740062e-08 NA NA NA hsa-miR-26b-5p IGF1 0.885393662798425 3.2116297961629e-06 -3.75951127345565 1.26264890381366e-10 mirMAP -0.940665920848216 3.14292070875382e-10 NA NA NA hsa-miR-27a-3p IGF1 1.66542180327138 4.93775737894805e-13 -3.75951127345565 1.26264890381366e-10 miRNAWalker2_validate;miRTarBase -0.651692554274928 7.73576562076687e-08 NA NA NA hsa-miR-29b-3p IGF1 1.65828197923813 1.02676780888141e-09 -3.75951127345565 1.26264890381366e-10 MirTarget -0.519110555190393 5.59140789276621e-07 25592039 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 IGF1 3' untranslated region 3'UTR; IGF1 an activator of PI3K/Akt signaling was confirmed as a novel target of miR-29b colorectal cancer hsa-miR-301a-3p IGF1 2.81024345929638 2.29784847962242e-17 -3.75951127345565 1.26264890381366e-10 MirTarget -0.801898835472881 2.70419582744703e-21 NA NA NA hsa-miR-3065-5p IGF1 2.74629919868982 1.86846589298284e-08 -3.75951127345565 1.26264890381366e-10 mirMAP -0.340906479396581 1.44245852597366e-06 NA NA NA hsa-miR-32-3p IGF1 2.02436999565685 5.94091197945307e-09 -3.75951127345565 1.26264890381366e-10 mirMAP -0.670318737511073 1.52748719371215e-13 NA NA NA hsa-miR-320a IGF1 0.438165828017084 0.0390159073347133 -3.75951127345565 1.26264890381366e-10 miRNATAP -0.87110280497324 9.95766777508728e-11 NA NA NA hsa-miR-320b IGF1 1.55692969039548 1.41071034251915e-08 -3.75951127345565 1.26264890381366e-10 miRNATAP -0.993279990978514 6.22780218264885e-24 NA NA NA hsa-miR-33a-3p IGF1 1.72765312072219 1.51784443453521e-07 -3.75951127345565 1.26264890381366e-10 MirTarget -0.862622681654972 2.52525229105421e-21 NA NA NA hsa-miR-3607-3p IGF1 2.68532138541128 5.66716351955047e-14 -3.75951127345565 1.26264890381366e-10 mirMAP -0.646493669321152 1.00233762873621e-16 NA NA NA hsa-miR-361-5p IGF1 0.971859117235239 5.30236555707088e-09 -3.75951127345565 1.26264890381366e-10 PITA;mirMAP -1.48168691679158 5.53863901928066e-19 NA NA NA hsa-miR-374b-3p IGF1 0.930487774873495 2.74420094310516e-05 -3.75951127345565 1.26264890381366e-10 mirMAP -0.498455115159369 0.000129551554566347 NA NA NA hsa-miR-3913-5p IGF1 2.44353493655328 8.95279496632448e-15 -3.75951127345565 1.26264890381366e-10 mirMAP -0.584661382885468 7.3573353974355e-11 NA NA NA hsa-miR-421 IGF1 1.17791565395543 6.78526676976629e-06 -3.75951127345565 1.26264890381366e-10 PITA -0.696572691037999 1.11839961387445e-10 NA NA NA hsa-miR-452-5p IGF1 1.37180058737183 0.00171494843537772 -3.75951127345565 1.26264890381366e-10 MirTarget;mirMAP -0.239891308263067 0.000253591244736158 NA NA NA hsa-miR-454-3p IGF1 2.47234127820054 1.12878018736016e-21 -3.75951127345565 1.26264890381366e-10 MirTarget -0.897384141255581 2.08224455125487e-17 NA NA NA hsa-miR-486-5p IGF1 -0.194913133034028 0.607377798807705 -3.75951127345565 1.26264890381366e-10 PITA;miRNATAP -0.336416232300254 9.17459110593128e-06 NA NA NA hsa-miR-576-5p IGF1 2.20467023993664 3.4053475193793e-19 -3.75951127345565 1.26264890381366e-10 PITA;mirMAP;miRNATAP -1.00551072603292 1.14064166854676e-20 NA NA NA hsa-miR-590-3p IGF1 2.59289455139753 1.03200520972022e-21 -3.75951127345565 1.26264890381366e-10 MirTarget;miRanda;mirMAP;miRNATAP -0.845684857318828 5.27514597787573e-17 NA NA NA hsa-miR-592 IGF1 1.51765968871077 0.000636335248013204 -3.75951127345565 1.26264890381366e-10 mirMAP -0.450455314337535 2.70073065710591e-12 NA NA NA hsa-miR-629-5p IGF1 2.10182419359635 1.51788571125757e-15 -3.75951127345565 1.26264890381366e-10 mirMAP -0.693559501922869 2.74994850835533e-11 NA NA NA hsa-miR-664a-3p IGF1 0.634721925861133 0.00520070178640421 -3.75951127345565 1.26264890381366e-10 mirMAP -0.350873716989665 0.00610206128936229 NA NA NA hsa-miR-940 IGF1 3.21011374578759 2.7923171128495e-14 -3.75951127345565 1.26264890381366e-10 MirTarget;PITA;miRNATAP -0.715084793572266 1.27978685880086e-25 NA NA NA hsa-let-7d-5p IGF1R 1.33236798905207 1.1741085658466e-13 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate;MirTarget;miRNATAP -0.233908899420042 0.000276801000319017 25287248 Focusing on the let-7d-5p/3p pair the respectively targeted IGF1R and KRAS were shown to be in a reverse relationship with expression of the respective miRNA which was confirmed in transient transfection assays using let-7d mimic or inhibitor; Targeting of KRAS by let-7d was previous reported; targeting of IGF1R by let-7d-5p was confirmed in luciferase assays in this study colon cancer hsa-let-7g-5p IGF1R 1.20061455355116 1.50237505511483e-12 -0.486024248749606 0.0460954581792042 MirTarget;miRNATAP -0.302735983859819 8.9121124787433e-06 NA NA NA hsa-let-7i-5p IGF1R 0.412877696970403 0.00622731051981756 -0.486024248749606 0.0460954581792042 MirTarget;miRNATAP -0.228891222780098 0.00403501843356413 NA NA NA hsa-miR-1226-3p IGF1R 1.38118928579963 0.000205503474787488 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate -0.10824109893534 0.00264508157056216 NA NA NA hsa-miR-1306-3p IGF1R 1.7835592527682 5.37873730566685e-08 -0.486024248749606 0.0460954581792042 mirMAP -0.140508877717541 0.000219830668957512 NA NA NA hsa-miR-140-3p IGF1R 0.0608890720479334 0.727716871248724 -0.486024248749606 0.0460954581792042 mirMAP -0.27831144732677 4.48014718263299e-05 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-140-5p IGF1R 0.844753502512594 3.73722278438606e-05 -0.486024248749606 0.0460954581792042 PITA;miRNATAP -0.210132849945263 0.000252820917193275 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-148a-5p IGF1R 1.16173838132242 0.000148929299881612 -0.486024248749606 0.0460954581792042 mirMAP -0.153273555432878 5.76643013870475e-05 NA NA NA hsa-miR-155-5p IGF1R 1.20164021433135 0.00086170622431261 -0.486024248749606 0.0460954581792042 mirMAP -0.109822477719586 0.000717019910707966 NA NA NA hsa-miR-15a-5p IGF1R 2.34669284378787 1.69544424500258e-23 -0.486024248749606 0.0460954581792042 miRNATAP -0.166867754420311 0.000454880786472648 NA NA NA hsa-miR-15b-3p IGF1R 2.33847028227712 4.29662877950836e-19 -0.486024248749606 0.0460954581792042 mirMAP -0.138682202682081 0.00131010066932468 NA NA NA hsa-miR-15b-5p IGF1R 1.57112623124278 9.14247846750597e-13 -0.486024248749606 0.0460954581792042 miRNATAP -0.248371255379639 1.81573519572013e-06 NA NA NA hsa-miR-16-1-3p IGF1R 2.56983217111073 3.02262181237943e-20 -0.486024248749606 0.0460954581792042 mirMAP -0.106436020324207 0.0104914815995738 NA NA NA hsa-miR-16-5p IGF1R 1.75824877145857 1.68592440033108e-16 -0.486024248749606 0.0460954581792042 miRNATAP -0.185976273412055 0.000509431308521588 23507142 Furthermore we confirmed that IGF1R is a direct target of miR-16; In clinical specimens IGF1R levels inversely correlate with miR-16 expression; Our results provide significant clues regarding the role of miR-16 as a tumor suppressor by targeting IGF1R in OS sarcoma hsa-miR-185-5p IGF1R 2.34016206907488 1.17481626642022e-26 -0.486024248749606 0.0460954581792042 MirTarget -0.210347183440742 3.18341012357928e-05 NA NA NA hsa-miR-186-5p IGF1R 1.47445398888668 3.0781726595413e-15 -0.486024248749606 0.0460954581792042 mirMAP -0.259580928228016 2.27679515390945e-05 NA NA NA hsa-miR-192-5p IGF1R 2.69002528723195 1.22990188194432e-16 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate -0.162071899497905 2.95566440166205e-06 NA NA NA hsa-miR-193a-5p IGF1R 0.562511612963676 0.0239254699649222 -0.486024248749606 0.0460954581792042 mirMAP -0.135722188768563 0.00426871718315317 NA NA NA hsa-miR-194-5p IGF1R 1.8992998339217 3.76507853301977e-10 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate;miRTarBase;miRNATAP -0.188748374877298 5.71579919612031e-07 NA NA NA hsa-miR-195-5p IGF1R -1.44753678070504 8.70594292149271e-09 -0.486024248749606 0.0460954581792042 miRNATAP -0.138117817160811 0.00280989255838415 NA NA NA hsa-miR-197-3p IGF1R 1.75733174019505 8.88576793100499e-13 -0.486024248749606 0.0460954581792042 mirMAP -0.184182858103751 7.83269013421259e-05 NA NA NA hsa-miR-19a-3p IGF1R 3.42309334186656 3.02671914353412e-28 -0.486024248749606 0.0460954581792042 mirMAP -0.10754867299782 0.00243372140663191 NA NA NA hsa-miR-215-5p IGF1R 2.30755467422978 2.38476032118039e-06 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate -0.142175668265091 3.8628174812409e-09 NA NA NA hsa-miR-29b-2-5p IGF1R 0.910668640983475 0.00666655585493488 -0.486024248749606 0.0460954581792042 mirMAP -0.119177500662335 0.000665741966203079 NA NA NA hsa-miR-29c-3p IGF1R -0.00968972577705429 0.97099586346872 -0.486024248749606 0.0460954581792042 mirMAP -0.157172588392593 0.000394988588911287 NA NA NA hsa-miR-30b-5p IGF1R 0.800822374912712 0.000133601914525413 -0.486024248749606 0.0460954581792042 mirMAP -0.136790931346952 0.0153105823842772 NA NA NA hsa-miR-30c-5p IGF1R 0.778774633108 0.000285599212429136 -0.486024248749606 0.0460954581792042 mirMAP;miRNATAP -0.215080796493845 8.67590028266986e-05 NA NA NA hsa-miR-30d-5p IGF1R 0.675423997639582 0.00270618816039773 -0.486024248749606 0.0460954581792042 mirMAP;miRNATAP -0.133794093695246 0.0109379152026071 NA NA NA hsa-miR-30e-5p IGF1R 1.23904909539663 1.35561917122157e-09 -0.486024248749606 0.0460954581792042 mirMAP -0.224447576166182 7.77702491429068e-05 NA NA NA hsa-miR-331-5p IGF1R 2.17414714166315 1.54547681391888e-18 -0.486024248749606 0.0460954581792042 PITA -0.102078651683119 0.0306115892779405 NA NA NA hsa-miR-339-5p IGF1R 2.68710938429893 3.03134080808154e-16 -0.486024248749606 0.0460954581792042 miRanda -0.120536510471461 0.000473712630520207 NA NA NA hsa-miR-342-3p IGF1R 1.49115144672245 1.43879249744621e-07 -0.486024248749606 0.0460954581792042 mirMAP -0.127400630242107 0.00191533765474422 NA NA NA hsa-miR-342-5p IGF1R 1.74634624752902 3.89286511372155e-11 -0.486024248749606 0.0460954581792042 mirMAP -0.17222881544086 7.73422132892045e-05 NA NA NA hsa-miR-3613-5p IGF1R 2.64358387329263 1.0373753017245e-24 -0.486024248749606 0.0460954581792042 mirMAP;miRNATAP -0.125077117428257 0.0049529824143567 NA NA NA hsa-miR-362-3p IGF1R 2.0756816987665 3.89026064579331e-12 -0.486024248749606 0.0460954581792042 PITA -0.206769365293673 1.43775490045472e-07 NA NA NA hsa-miR-3677-3p IGF1R 1.55935355925312 4.80239289905323e-06 -0.486024248749606 0.0460954581792042 MirTarget -0.175911681444773 2.01649902650337e-07 NA NA NA hsa-miR-374a-5p IGF1R 0.484615721953736 0.0042981729815149 -0.486024248749606 0.0460954581792042 mirMAP -0.234001149935664 0.000864680357370787 NA NA NA hsa-miR-374b-5p IGF1R 0.0654362503857184 0.722673188879465 -0.486024248749606 0.0460954581792042 mirMAP -0.260316989857322 5.53324694472522e-05 NA NA NA hsa-miR-378a-5p IGF1R 0.223456081148306 0.386368843153575 -0.486024248749606 0.0460954581792042 mirMAP -0.127780003468782 0.0054319364150493 24119742;25427715 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS ; liver cancer;sarcoma hsa-miR-3913-5p IGF1R 2.44353493655328 8.95279496632448e-15 -0.486024248749606 0.0460954581792042 mirMAP -0.126397785568049 0.000687296309514575 NA NA NA hsa-miR-409-5p IGF1R 1.56949123847358 5.91654175754272e-07 -0.486024248749606 0.0460954581792042 PITA -0.104622478580007 0.00774804832597773 NA NA NA hsa-miR-421 IGF1R 1.17791565395543 6.78526676976629e-06 -0.486024248749606 0.0460954581792042 miRanda -0.179133195485579 6.03309149743434e-05 NA NA NA hsa-miR-484 IGF1R 1.81844463411787 1.82951571230938e-15 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate -0.282538218482723 1.04528421031889e-08 NA NA NA hsa-miR-495-3p IGF1R -0.0847115949846082 0.763475496144456 -0.486024248749606 0.0460954581792042 mirMAP -0.119947784452941 0.00444753291132263 NA NA NA hsa-miR-497-5p IGF1R 0.0257087130056286 0.918145413833358 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate;miRTarBase;miRNATAP -0.152362590794185 0.00129782502934878 NA NA NA hsa-miR-500a-3p IGF1R 1.47161373123699 5.30571342631915e-09 -0.486024248749606 0.0460954581792042 mirMAP -0.308758568854319 7.46172041584498e-12 NA NA NA hsa-miR-532-5p IGF1R 1.55697650978597 1.57884735535196e-11 -0.486024248749606 0.0460954581792042 miRNATAP -0.305954968906114 5.01442184672658e-10 NA NA NA hsa-miR-542-3p IGF1R 1.18832665895751 1.98700670691565e-07 -0.486024248749606 0.0460954581792042 mirMAP -0.150251984416169 0.00332990570749663 NA NA NA hsa-miR-592 IGF1R 1.51765968871077 0.000636335248013204 -0.486024248749606 0.0460954581792042 PITA;miRNATAP -0.124822698210919 2.83708994200769e-06 NA NA NA hsa-miR-625-5p IGF1R 1.42540152147292 1.95797147911206e-06 -0.486024248749606 0.0460954581792042 MirTarget -0.148113785343487 0.000526615821219427 NA NA NA hsa-miR-664a-5p IGF1R 0.505019913598436 0.032933350691651 -0.486024248749606 0.0460954581792042 mirMAP -0.11199698919234 0.0260197126075394 NA NA NA hsa-miR-671-5p IGF1R 2.97733652243246 1.21148452344738e-23 -0.486024248749606 0.0460954581792042 mirMAP -0.129839479602332 0.00106882467611499 NA NA NA hsa-miR-7-1-3p IGF1R 1.84950311431067 1.25300363397654e-13 -0.486024248749606 0.0460954581792042 mirMAP -0.170630021804943 0.00020010536359991 NA NA NA hsa-miR-877-5p IGF1R 2.94916202082736 1.8151927276044e-13 -0.486024248749606 0.0460954581792042 MirTarget -0.105351058260924 0.00105209735401847 NA NA NA hsa-miR-92a-3p IGF1R 2.06460102658973 1.44784291084757e-19 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate -0.114848306889288 0.0209529487137771 NA NA NA hsa-miR-940 IGF1R 3.21011374578759 2.7923171128495e-14 -0.486024248749606 0.0460954581792042 mirMAP -0.112078867143816 0.000138658602668637 NA NA NA hsa-miR-98-5p IGF1R 1.11154309866014 1.24143909012085e-08 -0.486024248749606 0.0460954581792042 MirTarget -0.310419335327057 1.6607359063192e-07 NA NA NA hsa-miR-99b-5p IGF1R 0.814286288944185 0.000299800699512742 -0.486024248749606 0.0460954581792042 miRNATAP -0.14193096371114 0.00677531758993343 22425712 Furthermore ectopic transfection of miR-99 family members down-regulated the expression of insulin-like growth factor 1 receptor IGF1R and mechanistic target of rapamycin mTOR genes; The deregulation of miR-99 family contributes to the tumorigenesis of HNSCC in part by targeting IGF1R and mTOR signaling pathways tumorigenesis head and neck cancer hsa-miR-130a-3p IGF2 2.02021855058359 1.26427102520415e-11 0.0970288554818755 0.912383978798457 mirMAP -0.351941436541844 0.0117888842627487 NA NA NA hsa-miR-148a-3p IGF2 1.26728238710376 2.52325607402829e-06 0.0970288554818755 0.912383978798457 mirMAP -0.414453970496451 0.00835190565522827 NA NA NA hsa-miR-193a-3p IGF2 1.60460546928078 2.86169793322984e-07 0.0970288554818755 0.912383978798457 mirMAP -0.553479045878348 3.58467640429877e-05 NA NA NA hsa-miR-193a-5p IGF2 0.562511612963676 0.0239254699649222 0.0970288554818755 0.912383978798457 TargetScan -0.570992734200133 0.000865140051931084 NA NA NA hsa-miR-19a-3p IGF2 3.42309334186656 3.02671914353412e-28 0.0970288554818755 0.912383978798457 mirMAP -0.392861132545829 0.00218920494137348 NA NA NA hsa-miR-19b-3p IGF2 2.49529833021187 1.57028265846699e-23 0.0970288554818755 0.912383978798457 mirMAP -0.461868946453214 0.0043944070924483 NA NA NA hsa-miR-221-5p IGF2 -0.745357436702497 0.081887809839391 0.0970288554818755 0.912383978798457 mirMAP -0.261385058416875 0.0101529827457214 NA NA NA hsa-miR-224-3p IGF2 1.87536386559317 6.15140969394846e-05 0.0970288554818755 0.912383978798457 mirMAP -0.213824840075465 0.0239113409977905 NA NA NA hsa-miR-2355-5p IGF2 1.32510310704724 8.25139516692683e-07 0.0970288554818755 0.912383978798457 MirTarget -0.934940253226415 1.4332722095728e-09 NA NA NA hsa-miR-339-5p IGF2 2.68710938429893 3.03134080808154e-16 0.0970288554818755 0.912383978798457 mirMAP -0.35358009661054 0.00467145025038026 NA NA NA hsa-miR-34c-5p IGF2 2.07190852984647 7.35776320806257e-08 0.0970288554818755 0.912383978798457 mirMAP -0.395621340114303 0.000655839251233444 NA NA NA hsa-miR-361-3p IGF2 1.07367425434318 1.73142774168958e-09 0.0970288554818755 0.912383978798457 mirMAP -0.531470289140616 0.0255801216928642 NA NA NA hsa-miR-362-3p IGF2 2.0756816987665 3.89026064579331e-12 0.0970288554818755 0.912383978798457 miRanda -0.408260903092568 0.00451278900607031 NA NA NA hsa-miR-628-5p IGF2 0.799263053510813 2.28892357418044e-05 0.0970288554818755 0.912383978798457 mirMAP -0.638729704782253 0.00486077064668685 NA NA NA hsa-miR-9-5p IGF2 1.02304182473283 0.042901377604859 0.0970288554818755 0.912383978798457 mirMAP -0.229589246411698 0.00634499270083063 NA NA NA hsa-miR-146b-5p IKBKB 1.75587235896724 1.15724631266659e-07 -0.00227190214342876 0.988714147115007 miRanda -0.12253940493918 7.13410135054121e-08 NA NA NA hsa-miR-224-3p IL2RA 1.87536386559317 6.15140969394846e-05 -0.168267799080654 0.754364221522117 MirTarget -0.327905379108166 7.67886781749462e-09 NA NA NA hsa-miR-3065-3p IL2RA 2.16221780121195 9.65525739884541e-09 -0.168267799080654 0.754364221522117 MirTarget -0.260522406991479 0.000112050511124378 NA NA NA hsa-miR-3607-3p IL2RA 2.68532138541128 5.66716351955047e-14 -0.168267799080654 0.754364221522117 mirMAP -0.184080402382259 0.0111264335037544 NA NA NA hsa-miR-3677-3p IL2RA 1.55935355925312 4.80239289905323e-06 -0.168267799080654 0.754364221522117 MirTarget -0.149088365608177 0.0486998759790827 NA NA NA hsa-miR-375 IL2RA 1.13910305294079 0.0512283522214186 -0.168267799080654 0.754364221522117 miRanda -0.106576857812083 0.0163371615026233 NA NA NA hsa-let-7d-3p IL2RB 0.837345596411224 1.39469480391458e-05 -0.0233290268117248 0.954819309152745 mirMAP -0.369222486322037 0.000342913795676839 NA NA NA hsa-miR-125a-5p IL2RB 0.599529391575274 0.0102300147180307 -0.0233290268117248 0.954819309152745 miRanda -0.442253532537528 1.70969907539695e-07 NA NA NA hsa-miR-30b-3p IL2RB 0.834142820354026 0.000972582820878813 -0.0233290268117248 0.954819309152745 mirMAP -0.480203015370178 6.24300873871078e-10 NA NA NA hsa-miR-421 IL2RB 1.17791565395543 6.78526676976629e-06 -0.0233290268117248 0.954819309152745 mirMAP -0.187821218773603 0.0132150307245737 NA NA NA hsa-miR-421 IL2RG 1.17791565395543 6.78526676976629e-06 -0.126168361757179 0.782139842106464 miRanda;miRNATAP -0.272273105936814 0.00115453548509555 NA NA NA hsa-miR-491-5p IL2RG 0.615770352820862 0.0418295628761654 -0.126168361757179 0.782139842106464 miRanda -0.168541541048309 0.031563801699543 NA NA NA hsa-miR-331-3p IL4R 2.28379581858927 1.99663919173155e-18 -0.389473278837841 0.0949302027470816 miRNAWalker2_validate -0.220635955939197 7.76238081274503e-08 NA NA NA hsa-miR-339-5p IL4R 2.68710938429893 3.03134080808154e-16 -0.389473278837841 0.0949302027470816 miRanda -0.15226325804297 3.44301444278975e-06 NA NA NA hsa-miR-429 IL4R 4.48815175680773 2.44117492218206e-17 -0.389473278837841 0.0949302027470816 miRNATAP -0.126344342256496 2.7572092258889e-10 NA NA NA hsa-miR-491-5p IL4R 0.615770352820862 0.0418295628761654 -0.389473278837841 0.0949302027470816 miRanda -0.171311339821391 1.64313357660503e-05 NA NA NA hsa-let-7a-5p IL6 0.618599506841644 2.76973453058748e-05 -4.51457391074354 1.84664878324708e-10 miRNAWalker2_validate -1.49764192032347 2.38346175895915e-10 21352471;23977098 Knocking down IL-6 and Twist in HSCs significantly reduced let-7 and miR-181 expression and subsequently inhibited chemoresistance and cell invasion;Loss of let 7 microRNA upregulates IL 6 in bone marrow derived mesenchymal stem cells triggering a reactive stromal response to prostate cancer; We also found that IL-6 is a direct target gene for the let-7 microRNA which was downregulated in cancer-associated MSCs; The overexpression of let-7 via the transfection of let-7 precursors decreased IL-6 expression and repressed the adipogenic potential and metastasis-promoting activity of cancer-associated MSCs which was consistent with the inhibition of IL-6 3'UTR luciferase activity; Conversely the treatment of normal MSCs with let-7 inhibitors resulted in effects similar to those seen with IL-6; Taken together our data demonstrated that MSCs co-evolve with prostate cancer cells in the tumor microenvironment and the downregulation of let-7 by cancer-associated MSCs upregulates IL-6 expression drug resistance;drug resistance;metastasis liver cancer;prostate cancer hsa-miR-107 IL6 1.30977326593435 1.30372468603965e-11 -4.51457391074354 1.84664878324708e-10 miRanda -1.33183779333917 1.54734218444571e-14 NA NA NA hsa-miR-335-5p IL6 1.77247705492746 2.22457658872091e-06 -4.51457391074354 1.84664878324708e-10 miRNAWalker2_validate -0.467167119193204 3.30170788121676e-07 NA NA NA hsa-miR-361-5p IL6 0.971859117235239 5.30236555707088e-09 -4.51457391074354 1.84664878324708e-10 miRanda -1.82491350948499 1.24082346226555e-19 NA NA NA hsa-miR-429 IL6 4.48815175680773 2.44117492218206e-17 -4.51457391074354 1.84664878324708e-10 miRanda -0.671855968964194 6.61057721414734e-30 NA NA NA hsa-miR-98-5p IL6 1.11154309866014 1.24143909012085e-08 -4.51457391074354 1.84664878324708e-10 miRNAWalker2_validate -1.23406095672236 1.33158050901419e-12 25277211 miR 98 suppresses melanoma metastasis through a negative feedback loop with its target gene IL 6; We also found that IL-6 is a target gene of miR-98 and IL-6 represses miR-98 levels via the Stat3-NF-κB-lin28B pathway metastasis melanoma hsa-let-7e-5p IL6R 0.860104282510173 6.04758298373779e-05 -1.86576803083567 2.67166891084766e-06 miRNATAP -0.355369511566587 8.37378549008563e-05 NA NA NA hsa-let-7g-5p IL6R 1.20061455355116 1.50237505511483e-12 -1.86576803083567 2.67166891084766e-06 miRNATAP -0.5865859753066 1.60279544877185e-07 NA NA NA hsa-miR-103a-2-5p IL6R 2.47599305985086 7.933028987326e-11 -1.86576803083567 2.67166891084766e-06 mirMAP -0.279653165564326 5.81104413496993e-07 NA NA NA hsa-miR-106a-5p IL6R 2.48882002962836 1.99757727374521e-12 -1.86576803083567 2.67166891084766e-06 mirMAP -0.189044848105555 0.000396201599215425 NA NA NA hsa-miR-106b-5p IL6R 2.46782146831112 1.36171495805632e-23 -1.86576803083567 2.67166891084766e-06 mirMAP -0.545921256955192 6.72141166862895e-14 NA NA NA hsa-miR-125a-5p IL6R 0.599529391575274 0.0102300147180307 -1.86576803083567 2.67166891084766e-06 MirTarget;miRanda -0.430695896757453 1.91909957244903e-07 NA NA NA hsa-miR-130a-3p IL6R 2.02021855058359 1.26427102520415e-11 -1.86576803083567 2.67166891084766e-06 mirMAP -0.185169000844622 0.00364857336821356 NA NA NA hsa-miR-130b-3p IL6R 3.5350292994509 1.73934183852569e-27 -1.86576803083567 2.67166891084766e-06 mirMAP -0.368732744561779 1.67517848881662e-11 NA NA NA hsa-miR-141-3p IL6R 5.02396127982626 2.19224509139725e-24 -1.86576803083567 2.67166891084766e-06 MirTarget -0.23775486835915 6.49333048566365e-11 NA NA NA hsa-miR-141-5p IL6R 3.81419396518882 3.21977359736126e-18 -1.86576803083567 2.67166891084766e-06 MirTarget -0.207068782348747 8.62358173694999e-07 NA NA NA hsa-miR-17-5p IL6R 3.2710598467455 9.93128340539455e-27 -1.86576803083567 2.67166891084766e-06 mirMAP -0.333756021656699 1.48032494389695e-08 NA NA NA hsa-miR-182-5p IL6R 3.53923166221814 5.07781258121574e-21 -1.86576803083567 2.67166891084766e-06 mirMAP -0.308185867210701 1.67894161264071e-10 NA NA NA hsa-miR-186-5p IL6R 1.47445398888668 3.0781726595413e-15 -1.86576803083567 2.67166891084766e-06 mirMAP -0.500045040442012 6.86522427682879e-07 NA NA NA hsa-miR-192-5p IL6R 2.69002528723195 1.22990188194432e-16 -1.86576803083567 2.67166891084766e-06 mirMAP -0.216653822911565 0.000163354472974362 NA NA NA hsa-miR-193a-3p IL6R 1.60460546928078 2.86169793322984e-07 -1.86576803083567 2.67166891084766e-06 mirMAP -0.130823019043723 0.0336168147801737 NA NA NA hsa-miR-193b-3p IL6R 2.25711804611899 4.1940744806631e-14 -1.86576803083567 2.67166891084766e-06 mirMAP -0.152923395920601 0.0156662699756225 NA NA NA hsa-miR-197-3p IL6R 1.75733174019505 8.88576793100499e-13 -1.86576803083567 2.67166891084766e-06 MirTarget -0.392610198312442 2.82127657316037e-07 NA NA NA hsa-miR-200a-3p IL6R 4.59434485520731 6.38952518573476e-18 -1.86576803083567 2.67166891084766e-06 MirTarget -0.280132988638321 9.88549165158644e-17 NA NA NA hsa-miR-20a-5p IL6R 3.15577933619191 4.19753346442454e-25 -1.86576803083567 2.67166891084766e-06 mirMAP -0.341831252511955 8.08465079689935e-09 NA NA NA hsa-miR-20b-5p IL6R 2.07706563022469 1.10107236083433e-05 -1.86576803083567 2.67166891084766e-06 mirMAP -0.173346507000992 1.81889860281569e-05 NA NA NA hsa-miR-28-5p IL6R 0.230152919654905 0.0742909586754846 -1.86576803083567 2.67166891084766e-06 mirMAP -0.445627685956472 0.00421342118577506 NA NA NA hsa-miR-301a-3p IL6R 2.81024345929638 2.29784847962242e-17 -1.86576803083567 2.67166891084766e-06 mirMAP -0.346207501246887 3.74645493389162e-09 NA NA NA hsa-miR-3065-5p IL6R 2.74629919868982 1.86846589298284e-08 -1.86576803083567 2.67166891084766e-06 mirMAP -0.215521603126446 6.01795162352935e-06 NA NA NA hsa-miR-30b-5p IL6R 0.800822374912712 0.000133601914525413 -1.86576803083567 2.67166891084766e-06 mirMAP -0.216302759975483 0.0201581087173427 NA NA NA hsa-miR-30c-5p IL6R 0.778774633108 0.000285599212429136 -1.86576803083567 2.67166891084766e-06 mirMAP -0.357730501275482 7.58292460792626e-05 NA NA NA hsa-miR-30d-5p IL6R 0.675423997639582 0.00270618816039773 -1.86576803083567 2.67166891084766e-06 mirMAP -0.310006276899415 0.000334351035391643 NA NA NA hsa-miR-30e-5p IL6R 1.23904909539663 1.35561917122157e-09 -1.86576803083567 2.67166891084766e-06 mirMAP -0.450037358977164 1.41115867585131e-06 NA NA NA hsa-miR-320b IL6R 1.55692969039548 1.41071034251915e-08 -1.86576803083567 2.67166891084766e-06 miRanda;miRNATAP -0.156061169485727 0.0257833362287906 NA NA NA hsa-miR-330-3p IL6R 0.876747334239085 0.00073709016089703 -1.86576803083567 2.67166891084766e-06 miRNATAP -0.177412033833072 0.0178867244488029 NA NA NA hsa-miR-331-3p IL6R 2.28379581858927 1.99663919173155e-18 -1.86576803083567 2.67166891084766e-06 MirTarget -0.286157934626183 6.1127020326213e-05 NA NA NA hsa-miR-335-5p IL6R 1.77247705492746 2.22457658872091e-06 -1.86576803083567 2.67166891084766e-06 mirMAP -0.268753965716292 1.15867215559052e-07 NA NA NA hsa-miR-33a-5p IL6R 3.79671563098419 1.15966309820345e-18 -1.86576803083567 2.67166891084766e-06 mirMAP -0.205688942132961 1.09391389822686e-05 NA NA NA hsa-miR-34a-5p IL6R 1.9016323452565 1.43092834643601e-14 -1.86576803083567 2.67166891084766e-06 MirTarget -0.286520476038065 0.000171312695111806 NA NA NA hsa-miR-421 IL6R 1.17791565395543 6.78526676976629e-06 -1.86576803083567 2.67166891084766e-06 mirMAP -0.195154738362018 0.00842534304798536 NA NA NA hsa-miR-454-3p IL6R 2.47234127820054 1.12878018736016e-21 -1.86576803083567 2.67166891084766e-06 mirMAP -0.34587032830449 2.25174449017626e-06 NA NA NA hsa-miR-484 IL6R 1.81844463411787 1.82951571230938e-15 -1.86576803083567 2.67166891084766e-06 MirTarget -0.433592636178605 1.10167451298998e-07 NA NA NA hsa-miR-501-5p IL6R 1.93654809410041 1.3779381780759e-10 -1.86576803083567 2.67166891084766e-06 miRNATAP -0.220656896683197 0.000676165915415221 NA NA NA hsa-miR-576-5p IL6R 2.20467023993664 3.4053475193793e-19 -1.86576803083567 2.67166891084766e-06 mirMAP -0.324022701493948 1.74337424075385e-05 NA NA NA hsa-miR-590-3p IL6R 2.59289455139753 1.03200520972022e-21 -1.86576803083567 2.67166891084766e-06 mirMAP -0.160281674908149 0.0228989302000628 NA NA NA hsa-miR-590-5p IL6R 3.18300989862077 2.06813568597893e-26 -1.86576803083567 2.67166891084766e-06 MirTarget;miRNATAP -0.269600006996991 1.54974226114691e-05 NA NA NA hsa-miR-93-5p IL6R 3.03961860136032 1.11672209617395e-24 -1.86576803083567 2.67166891084766e-06 mirMAP -0.461620151648295 1.68707665863151e-14 NA NA NA hsa-miR-942-5p IL6R 2.35195531153712 5.45059325728841e-16 -1.86576803083567 2.67166891084766e-06 MirTarget -0.130829802134946 0.0437842831734132 NA NA NA hsa-miR-98-5p IL6R 1.11154309866014 1.24143909012085e-08 -1.86576803083567 2.67166891084766e-06 miRNAWalker2_validate -0.469481304122954 1.71027380188651e-06 NA NA NA hsa-miR-126-5p IL7 0.895338176458417 2.33372756450713e-05 -0.911814562072489 0.00593853142002263 mirMAP -0.183223096233096 0.0159832188215214 NA NA NA hsa-miR-192-5p IL7 2.69002528723195 1.22990188194432e-16 -0.911814562072489 0.00593853142002263 miRNAWalker2_validate -0.250002092588449 1.12337201771153e-07 NA NA NA hsa-miR-215-5p IL7 2.30755467422978 2.38476032118039e-06 -0.911814562072489 0.00593853142002263 miRNAWalker2_validate -0.106369371171006 0.00144995776024937 NA NA NA hsa-miR-335-3p IL7 3.08791651139852 5.31309869723517e-12 -0.911814562072489 0.00593853142002263 mirMAP -0.228749088974194 2.2128548626284e-11 NA NA NA hsa-miR-335-5p IL7 1.77247705492746 2.22457658872091e-06 -0.911814562072489 0.00593853142002263 miRNAWalker2_validate -0.226914161492099 6.05873766223422e-08 NA NA NA hsa-miR-429 IL7 4.48815175680773 2.44117492218206e-17 -0.911814562072489 0.00593853142002263 miRanda -0.132768744973272 4.22861280358326e-06 NA NA NA hsa-miR-542-3p IL7 1.18832665895751 1.98700670691565e-07 -0.911814562072489 0.00593853142002263 miRanda -0.306181619758953 1.01457752215632e-05 NA NA NA hsa-miR-125a-5p IL7R 0.599529391575274 0.0102300147180307 -1.05033388888472 0.0658543700402536 miRanda -0.70343309526522 1.80486059514543e-09 NA NA NA hsa-miR-129-5p IL7R -0.524170159980738 0.222582956006346 -1.05033388888472 0.0658543700402536 miRanda;mirMAP -0.159763515609224 0.0149914100365471 NA NA NA hsa-miR-181c-5p IL7R 1.58587920618301 1.57506918816933e-10 -1.05033388888472 0.0658543700402536 mirMAP -0.496371141599136 5.05532021358559e-06 NA NA NA hsa-miR-26b-5p IL7R 0.885393662798425 3.2116297961629e-06 -1.05033388888472 0.0658543700402536 miRNAWalker2_validate -0.309468489953212 0.0338128004203917 NA NA NA hsa-miR-3065-5p IL7R 2.74629919868982 1.86846589298284e-08 -1.05033388888472 0.0658543700402536 mirMAP -0.303894968324891 7.17685947412129e-06 NA NA NA hsa-miR-330-3p IL7R 0.876747334239085 0.00073709016089703 -1.05033388888472 0.0658543700402536 miRNATAP -0.503498227571291 1.78992992142017e-06 NA NA NA hsa-miR-335-3p IL7R 3.08791651139852 5.31309869723517e-12 -1.05033388888472 0.0658543700402536 mirMAP -0.274186508929196 4.22202008391783e-06 NA NA NA hsa-miR-450b-5p IL7R 1.69244418548325 1.68064054148881e-10 -1.05033388888472 0.0658543700402536 mirMAP -0.225810857440466 0.0278018805715008 NA NA NA hsa-miR-501-5p IL7R 1.93654809410041 1.3779381780759e-10 -1.05033388888472 0.0658543700402536 mirMAP -0.280190017844517 0.00242876728641734 NA NA NA hsa-miR-508-3p IL7R 1.05493034310846 0.0393857095042515 -1.05033388888472 0.0658543700402536 mirMAP -0.141480471119692 0.0102247623467109 NA NA NA hsa-miR-576-5p IL7R 2.20467023993664 3.4053475193793e-19 -1.05033388888472 0.0658543700402536 mirMAP -0.425928935231224 7.31668657168399e-05 NA NA NA hsa-miR-7-1-3p IL7R 1.84950311431067 1.25300363397654e-13 -1.05033388888472 0.0658543700402536 mirMAP -0.311333751551424 0.00392955547080483 NA NA NA hsa-let-7a-3p INSR 1.42015538786275 7.03375209382654e-13 -0.335737111104281 0.0754278446119288 mirMAP -0.15816973369539 0.000461473183490821 NA NA NA hsa-let-7b-3p INSR 0.868207752019623 1.30460056774366e-05 -0.335737111104281 0.0754278446119288 mirMAP -0.18259237309381 6.27697448618197e-05 NA NA NA hsa-let-7f-1-3p INSR 1.55054488387679 7.31326775537952e-11 -0.335737111104281 0.0754278446119288 mirMAP -0.234879100967927 6.9044840520178e-10 NA NA NA hsa-let-7i-5p INSR 0.412877696970403 0.00622731051981756 -0.335737111104281 0.0754278446119288 miRNATAP -0.341000101339301 1.99898841669127e-08 NA NA NA hsa-miR-127-5p INSR 1.19850695520181 4.10976607177645e-05 -0.335737111104281 0.0754278446119288 PITA -0.114659842304268 0.000209322472841496 NA NA NA hsa-miR-142-5p INSR 1.17581605694506 0.0018174701991234 -0.335737111104281 0.0754278446119288 mirMAP -0.184533831964077 2.57101036960177e-15 NA NA NA hsa-miR-21-5p INSR 2.73773305747971 1.38864982139576e-43 -0.335737111104281 0.0754278446119288 mirMAP -0.288296420322576 1.5840822983789e-12 24804226;27220494;21618027 Downregulation of miR-21 in radioresistant NSCLC A549 cells inhibited the colony-forming ability and proliferation of A549 cells after IR; Moreover silencing miR-21 enhanced apoptosis of A549 cells induced by IR accompanied by decreased phosphorylated-Akt protein level; However PI3K activator IGF-1 reversed suppression of phosphorylated-Akt protein level and promotion of apoptosis of A549 cells after IR caused by miR-21 knockdown; Silencing miR-21 in radioresistant NSCLC A549 cells sensitized them to IR by inhibiting cell proliferation and enhancing cell apoptosis through inhibition of PI3K/Akt signaling pathway;In addition we also demonstrated that miR-21 confers decreased autophagy in cervical cancer cells after IR via the Akt-mTOR signaling pathway;In this study we found that miR-21 expression was upregulated in response to ionizing radiation IR in U251 cells which suggested that miR-21 could be involved in the response of U251 cells to radiation; We showed that a miR-21 inhibitor enhanced IR-induced glioblastoma cell growth arrest and increased the level of apoptosis which was probably caused by abrogation of the G2-M arrest induced by IR ;;drug resistance lung squamous cell cancer;cervical and endocervical cancer;glioblastoma hsa-miR-27a-3p INSR 1.66542180327138 4.93775737894805e-13 -0.335737111104281 0.0754278446119288 miRNATAP -0.257598888912134 9.95729032473756e-12 NA NA NA hsa-miR-342-3p INSR 1.49115144672245 1.43879249744621e-07 -0.335737111104281 0.0754278446119288 miRanda -0.173236629545461 3.38807506976711e-08 NA NA NA hsa-miR-424-5p INSR 1.61930224569578 1.89642549274994e-10 -0.335737111104281 0.0754278446119288 miRNATAP -0.111271098127559 0.0015781856467318 NA NA NA hsa-miR-590-3p INSR 2.59289455139753 1.03200520972022e-21 -0.335737111104281 0.0754278446119288 PITA;miRanda;mirMAP;miRNATAP -0.109443531364485 0.000887859920453394 NA NA NA hsa-miR-126-3p IRS1 1.6384689127743 1.4473425456641e-10 -0.851786005843366 0.00822245753156005 miRNAWalker2_validate;miRTarBase;miRNATAP -0.288428290430461 1.25837179330996e-06 24312276;23981989;26893720 Down regulation of miR 126 is associated with colorectal cancer cells proliferation migration and invasion by targeting IRS 1 via the AKT and ERK1/2 signaling pathways; In this study we identified the potential effects of miR-126 on some important biological properties of CRC cells and clarified the regulation of insulin receptor substrate 1 IRS-1 and its possible signaling pathway by miR-126; The 3'-untranslated region 3'-UTR of IRS-1 regulated by miR-126 was analyzed by using a dual-luciferase reporter assay; We found that IRS-1 is the functional downstream target of miR-126 by directly targeting the 3'-UTR of IRS-1; Endogenous miR-126 and exogenous miR-126 mimic inhibited IRS-1 expression; Furthermore gain-of-function or loss-of-function studies showed that over-expression of miR-126 down-regulated IRS-1 suppressed AKT and ERK1/2 activation CRC cells proliferation migration invasion and caused cell cycle arrest but had no effect on cell apoptosis; Knockdown of miR-126 promoted these processes in HCT-116 cells and promoted AKT and ERK1/2 activation by up-regulating the expression of the IRS-1 protein; MiR-126 may play roles in regulation of the biological behavior of CRC cells at least in part by targeting IRS-1 via AKT and ERK1/2 signaling pathways;It has been shown that IRS1 SLC75A and TOM1 were the potential target genes of miR-126 in colon cancer;Molecular mechanism investigation established that insulin receptor substrate 1 IRS1 functioned as a direct miR-126 target and its expression was negatively regulated by miR-126 at a post-transcriptional level in the SKOV3 cells; Additionally the overexpression of IRS1 reversed the inhibitory effect of miR-126 overexpression on SKOV3 cell migration and invasion; In conclusion the current study demonstrated that miR-126 inhibited EC cell migration and invasion at least partially through the direct targeting of IRS1 suggesting that miR-126 may aid the treatment of EC metastasis ;;cell migration;metastasis colorectal cancer;colon cancer;endometrial cancer hsa-miR-1271-5p IRS1 0.970418832993172 0.000609742584380688 -0.851786005843366 0.00822245753156005 MirTarget -0.121619255600699 0.0278675997772774 NA NA NA hsa-miR-128-3p IRS1 1.63756041666078 6.79626586407187e-14 -0.851786005843366 0.00822245753156005 MirTarget -0.230857412063909 0.000928301106826369 26352220 In addition insulin receptor substrate 1 IRS1 a key mediator in oncogenic insulin-like growth factor IGF signaling was confirmed as a direct target of miR-128 by a luciferase reporter assay; Western blot analysis indicated that the overexpression of miR-128 significantly downregulated IRS1 expression and its downstream Akt signaling in CRC cells; Moreover miR-128 was negatively associated with IRS1 in CRC tissues compared to adjacent non-tumor tissues; Taken together these data suggested that miR-128 serves as a tumor suppressor and blocks CRC growth and metastasis by targeting IRS1 metastasis colorectal cancer hsa-miR-142-5p IRS1 1.17581605694506 0.0018174701991234 -0.851786005843366 0.00822245753156005 MirTarget;PITA -0.162709282504736 7.4737363899194e-05 NA NA NA hsa-miR-148a-3p IRS1 1.26728238710376 2.52325607402829e-06 -0.851786005843366 0.00822245753156005 miRNAWalker2_validate;miRTarBase -0.13458990463138 0.0196263890531715 NA NA NA hsa-miR-17-3p IRS1 2.2704817679209 1.1667437320211e-22 -0.851786005843366 0.00822245753156005 MirTarget -0.354313462939604 2.30026319997462e-08 NA NA NA hsa-miR-30c-5p IRS1 0.778774633108 0.000285599212429136 -0.851786005843366 0.00822245753156005 MirTarget;miRNATAP -0.148107410430711 0.042875745264385 NA NA NA hsa-miR-30e-5p IRS1 1.23904909539663 1.35561917122157e-09 -0.851786005843366 0.00822245753156005 MirTarget -0.221461929314315 0.00340873662378119 NA NA NA hsa-miR-338-3p IRS1 0.453166438193782 0.144583389707558 -0.851786005843366 0.00822245753156005 miRanda -0.262034676084363 1.45781485432948e-07 NA NA NA hsa-miR-338-5p IRS1 -0.577691606146419 0.0472212680542825 -0.851786005843366 0.00822245753156005 PITA;miRNATAP -0.182539116228051 0.000747817233267703 NA NA NA hsa-miR-33a-5p IRS1 3.79671563098419 1.15966309820345e-18 -0.851786005843366 0.00822245753156005 MirTarget -0.105113689881829 0.00547712974900804 NA NA NA hsa-miR-421 IRS1 1.17791565395543 6.78526676976629e-06 -0.851786005843366 0.00822245753156005 PITA;miRanda;miRNATAP -0.190666940627758 0.00133004715088958 NA NA NA hsa-miR-590-3p IRS1 2.59289455139753 1.03200520972022e-21 -0.851786005843366 0.00822245753156005 PITA;miRanda;miRNATAP -0.2289962787096 4.65539357390253e-05 NA NA NA hsa-miR-628-5p IRS1 0.799263053510813 2.28892357418044e-05 -0.851786005843366 0.00822245753156005 miRNATAP -0.356362188817271 1.62298962554325e-05 NA NA NA hsa-miR-660-5p IRS1 1.82692095272076 1.92040083607196e-13 -0.851786005843366 0.00822245753156005 MirTarget;miRNATAP -0.446607750875128 7.07986693383541e-14 NA NA NA hsa-miR-7-5p IRS1 2.28980165299999 1.5131097560452e-07 -0.851786005843366 0.00822245753156005 miRNAWalker2_validate;miRTarBase;MirTarget -0.125138886548685 0.000981839028960246 NA NA NA hsa-miR-96-5p IRS1 4.89433085814374 1.92000659886961e-31 -0.851786005843366 0.00822245753156005 MirTarget;TargetScan;miRNATAP -0.104968605701419 0.00302987014600172 21993544 hsa miR 96 up regulates MAP4K1 and IRS1 and may function as a promising diagnostic marker in human bladder urothelial carcinomas; Altogether these results suggest that hsa-miR-96 may affect the growth of bladder cancer cells by up-regulating IRS1 and MAP4K1 levels functioning as a promising diagnostic marker in human bladder urothelial carcinomas bladder cancer hsa-let-7a-5p ITGA1 0.618599506841644 2.76973453058748e-05 -1.43194652766846 3.62878143052896e-06 TargetScan -0.662726383825578 7.64821119111743e-11 NA NA NA hsa-miR-107 ITGA1 1.30977326593435 1.30372468603965e-11 -1.43194652766846 3.62878143052896e-06 miRanda -0.476060804859469 3.04760028869376e-10 NA NA NA hsa-miR-126-5p ITGA1 0.895338176458417 2.33372756450713e-05 -1.43194652766846 3.62878143052896e-06 mirMAP -0.214241662003545 0.00268650706742711 NA NA NA hsa-miR-129-5p ITGA1 -0.524170159980738 0.222582956006346 -1.43194652766846 3.62878143052896e-06 miRanda -0.102611613185438 0.00422559452162939 NA NA NA hsa-miR-140-5p ITGA1 0.844753502512594 3.73722278438606e-05 -1.43194652766846 3.62878143052896e-06 miRanda -0.171525094262808 0.0204550499904173 NA NA NA hsa-miR-141-5p ITGA1 3.81419396518882 3.21977359736126e-18 -1.43194652766846 3.62878143052896e-06 MirTarget -0.323264911863107 3.42360805431411e-25 NA NA NA hsa-miR-181a-5p ITGA1 2.29556023480783 1.8138457900616e-21 -1.43194652766846 3.62878143052896e-06 mirMAP -0.328392383791084 2.71785057760598e-08 NA NA NA hsa-miR-181b-5p ITGA1 2.49307679431293 3.92829250217627e-20 -1.43194652766846 3.62878143052896e-06 mirMAP -0.288195577702829 4.39641094389566e-08 NA NA NA hsa-miR-181c-5p ITGA1 1.58587920618301 1.57506918816933e-10 -1.43194652766846 3.62878143052896e-06 mirMAP -0.361582429089443 8.36639553328656e-10 NA NA NA hsa-miR-186-5p ITGA1 1.47445398888668 3.0781726595413e-15 -1.43194652766846 3.62878143052896e-06 mirMAP -0.688431895900043 9.47139653203836e-20 NA NA NA hsa-miR-200a-5p ITGA1 3.86316681673704 1.81076942093171e-15 -1.43194652766846 3.62878143052896e-06 mirMAP -0.300387708728853 1.866486144586e-26 NA NA NA hsa-miR-200b-3p ITGA1 3.78235093249346 3.18343003239465e-14 -1.43194652766846 3.62878143052896e-06 MirTarget -0.293788237504587 1.80648566656499e-26 NA NA NA hsa-miR-200b-5p ITGA1 2.54484902707822 1.59240467582976e-06 -1.43194652766846 3.62878143052896e-06 mirMAP -0.269100640670948 1.09729073720052e-18 NA NA NA hsa-miR-200c-3p ITGA1 3.50132673580082 2.42716349086937e-15 -1.43194652766846 3.62878143052896e-06 MirTarget -0.340248985237553 3.10844394076231e-28 NA NA NA hsa-miR-21-5p ITGA1 2.73773305747971 1.38864982139576e-43 -1.43194652766846 3.62878143052896e-06 mirMAP -0.240917823362669 0.000492330681791514 NA NA NA hsa-miR-3065-5p ITGA1 2.74629919868982 1.86846589298284e-08 -1.43194652766846 3.62878143052896e-06 MirTarget -0.194432586886436 1.32832142326783e-07 NA NA NA hsa-miR-30d-3p ITGA1 0.977747550180601 4.3048212205381e-05 -1.43194652766846 3.62878143052896e-06 MirTarget -0.537437896148661 7.72737945201165e-19 NA NA NA hsa-miR-30e-3p ITGA1 -0.215663037684509 0.235375122783546 -1.43194652766846 3.62878143052896e-06 MirTarget -0.454369369999055 4.96280640430499e-08 NA NA NA hsa-miR-32-3p ITGA1 2.02436999565685 5.94091197945307e-09 -1.43194652766846 3.62878143052896e-06 mirMAP -0.306515059666328 1.42669705340451e-10 NA NA NA hsa-miR-320a ITGA1 0.438165828017084 0.0390159073347133 -1.43194652766846 3.62878143052896e-06 miRanda -0.491407317469224 2.32788904318658e-12 NA NA NA hsa-miR-320b ITGA1 1.55692969039548 1.41071034251915e-08 -1.43194652766846 3.62878143052896e-06 miRanda -0.409314147683171 7.84794604717693e-15 NA NA NA hsa-miR-330-3p ITGA1 0.876747334239085 0.00073709016089703 -1.43194652766846 3.62878143052896e-06 mirMAP -0.388967021186556 7.81232536628292e-12 NA NA NA hsa-miR-330-5p ITGA1 1.15100069700871 4.85551805046014e-07 -1.43194652766846 3.62878143052896e-06 miRanda -0.404318174729703 3.58062154198523e-10 NA NA NA hsa-miR-335-3p ITGA1 3.08791651139852 5.31309869723517e-12 -1.43194652766846 3.62878143052896e-06 mirMAP -0.185718095573507 9.62944845328966e-09 NA NA NA hsa-miR-335-5p ITGA1 1.77247705492746 2.22457658872091e-06 -1.43194652766846 3.62878143052896e-06 miRNAWalker2_validate -0.215447169676611 4.46618823770219e-08 NA NA NA hsa-miR-3607-3p ITGA1 2.68532138541128 5.66716351955047e-14 -1.43194652766846 3.62878143052896e-06 MirTarget -0.304881767414594 1.03041772487336e-13 NA NA NA hsa-miR-361-5p ITGA1 0.971859117235239 5.30236555707088e-09 -1.43194652766846 3.62878143052896e-06 miRanda -0.837453081600318 2.65952140978618e-22 NA NA NA hsa-miR-362-3p ITGA1 2.0756816987665 3.89026064579331e-12 -1.43194652766846 3.62878143052896e-06 miRanda -0.29802430078252 2.88988847820282e-09 NA NA NA hsa-miR-374a-5p ITGA1 0.484615721953736 0.0042981729815149 -1.43194652766846 3.62878143052896e-06 mirMAP -0.405069162680457 6.16064316473606e-06 NA NA NA hsa-miR-421 ITGA1 1.17791565395543 6.78526676976629e-06 -1.43194652766846 3.62878143052896e-06 miRanda -0.222356551672346 0.000104477581633259 NA NA NA hsa-miR-429 ITGA1 4.48815175680773 2.44117492218206e-17 -1.43194652766846 3.62878143052896e-06 MirTarget;miRanda -0.276383076319835 5.72182761751296e-27 NA NA NA hsa-miR-452-5p ITGA1 1.37180058737183 0.00171494843537772 -1.43194652766846 3.62878143052896e-06 mirMAP -0.12277003990685 0.000340196953017899 NA NA NA hsa-miR-576-5p ITGA1 2.20467023993664 3.4053475193793e-19 -1.43194652766846 3.62878143052896e-06 mirMAP -0.446624020940535 5.82126170537541e-15 NA NA NA hsa-miR-590-3p ITGA1 2.59289455139753 1.03200520972022e-21 -1.43194652766846 3.62878143052896e-06 miRanda;mirMAP -0.425812913161097 8.19455322160532e-16 NA NA NA hsa-miR-590-5p ITGA1 3.18300989862077 2.06813568597893e-26 -1.43194652766846 3.62878143052896e-06 miRanda;mirMAP -0.435709621715493 8.7432992082921e-21 NA NA NA hsa-miR-664a-3p ITGA1 0.634721925861133 0.00520070178640421 -1.43194652766846 3.62878143052896e-06 mirMAP -0.581383171935268 1.03224556337196e-19 NA NA NA hsa-miR-7-1-3p ITGA1 1.84950311431067 1.25300363397654e-13 -1.43194652766846 3.62878143052896e-06 mirMAP -0.387624949164747 1.9682068299961e-11 NA NA NA hsa-miR-944 ITGA1 2.91186649218281 1.31574753528144e-06 -1.43194652766846 3.62878143052896e-06 mirMAP -0.199948076285366 6.26769902637697e-16 NA NA NA hsa-let-7g-3p ITGA10 3.26398061402445 3.96263126107645e-25 -1.23167280663865 2.76541818862273e-05 MirTarget;miRNATAP -0.218236127600325 5.63309168140577e-07 NA NA NA hsa-miR-107 ITGA10 1.30977326593435 1.30372468603965e-11 -1.23167280663865 2.76541818862273e-05 miRanda -0.317902442126366 1.17632529486733e-05 NA NA NA hsa-miR-15a-5p ITGA10 2.34669284378787 1.69544424500258e-23 -1.23167280663865 2.76541818862273e-05 MirTarget -0.141352684611656 0.0149677519600305 NA NA NA hsa-miR-15b-5p ITGA10 1.57112623124278 9.14247846750597e-13 -1.23167280663865 2.76541818862273e-05 MirTarget -0.381043720213013 1.26622750178727e-09 NA NA NA hsa-miR-16-5p ITGA10 1.75824877145857 1.68592440033108e-16 -1.23167280663865 2.76541818862273e-05 MirTarget -0.320934694235216 6.71964913643131e-07 NA NA NA hsa-miR-320b ITGA10 1.55692969039548 1.41071034251915e-08 -1.23167280663865 2.76541818862273e-05 miRanda -0.220782531056868 1.60257693423991e-05 NA NA NA hsa-miR-324-5p ITGA10 2.95683728155095 1.32960514360912e-20 -1.23167280663865 2.76541818862273e-05 miRanda;miRNATAP -0.163793808505843 0.00013276264415894 NA NA NA hsa-miR-424-5p ITGA10 1.61930224569578 1.89642549274994e-10 -1.23167280663865 2.76541818862273e-05 MirTarget -0.113376714136751 0.0411675786313485 NA NA NA hsa-miR-429 ITGA10 4.48815175680773 2.44117492218206e-17 -1.23167280663865 2.76541818862273e-05 miRanda;miRNATAP -0.110056110109756 1.96037682895123e-05 NA NA NA hsa-miR-484 ITGA10 1.81844463411787 1.82951571230938e-15 -1.23167280663865 2.76541818862273e-05 miRNATAP -0.231321318200269 0.000137669160361238 NA NA NA hsa-miR-940 ITGA10 3.21011374578759 2.7923171128495e-14 -1.23167280663865 2.76541818862273e-05 MirTarget;miRNATAP -0.183743224186045 2.28524264387184e-07 NA NA NA hsa-miR-421 ITGA11 1.17791565395543 6.78526676976629e-06 -0.415680854945489 0.417633091693705 mirMAP -0.545398795378909 4.33226247307667e-09 NA NA NA hsa-miR-429 ITGA11 4.48815175680773 2.44117492218206e-17 -0.415680854945489 0.417633091693705 miRNATAP -0.31747284047985 3.67564734728995e-13 NA NA NA hsa-miR-532-5p ITGA11 1.55697650978597 1.57884735535196e-11 -0.415680854945489 0.417633091693705 miRNATAP -0.441965710017999 2.4454912458658e-05 NA NA NA hsa-miR-103a-3p ITGA2 1.44083190496858 1.53799939616416e-13 0.780933228446094 0.0360115182087058 miRNAWalker2_validate;MirTarget;miRNATAP -0.259499020989338 0.00419323029610024 NA NA NA hsa-miR-107 ITGA2 1.30977326593435 1.30372468603965e-11 0.780933228446094 0.0360115182087058 MirTarget;miRanda;miRNATAP -0.262580981852226 0.00426625602830046 NA NA NA hsa-miR-139-5p ITGA2 -1.52606598644743 1.20474151350665e-08 0.780933228446094 0.0360115182087058 PITA;miRanda -0.249459221893773 0.000164230962733441 NA NA NA hsa-miR-186-5p ITGA2 1.47445398888668 3.0781726595413e-15 0.780933228446094 0.0360115182087058 mirMAP -0.270901743611912 0.00407079218140721 NA NA NA hsa-miR-195-5p ITGA2 -1.44753678070504 8.70594292149271e-09 0.780933228446094 0.0360115182087058 MirTarget;miRNATAP -0.291851965767148 3.37825228491837e-05 NA NA NA hsa-miR-301a-3p ITGA2 2.81024345929638 2.29784847962242e-17 0.780933228446094 0.0360115182087058 mirMAP -0.143921799403505 0.00934010376589392 NA NA NA hsa-miR-30b-5p ITGA2 0.800822374912712 0.000133601914525413 0.780933228446094 0.0360115182087058 mirMAP -0.261141707592115 0.00243365828617581 NA NA NA hsa-miR-30c-5p ITGA2 0.778774633108 0.000285599212429136 0.780933228446094 0.0360115182087058 mirMAP -0.357208346841337 1.97878207915458e-05 NA NA NA hsa-miR-30d-5p ITGA2 0.675423997639582 0.00270618816039773 0.780933228446094 0.0360115182087058 mirMAP -0.275205640738548 0.000600053227514717 NA NA NA hsa-miR-30e-5p ITGA2 1.23904909539663 1.35561917122157e-09 0.780933228446094 0.0360115182087058 mirMAP -0.385351859813687 8.81532571140156e-06 NA NA NA hsa-miR-324-5p ITGA2 2.95683728155095 1.32960514360912e-20 0.780933228446094 0.0360115182087058 miRanda -0.131061354284265 0.0156293881757323 NA NA NA hsa-miR-326 ITGA2 0.715313016136042 0.0610265683213359 0.780933228446094 0.0360115182087058 PITA -0.197349558072418 2.85604059843187e-05 NA NA NA hsa-miR-33a-3p ITGA2 1.72765312072219 1.51784443453521e-07 0.780933228446094 0.0360115182087058 mirMAP -0.141231364730912 0.0177299358441449 NA NA NA hsa-miR-362-3p ITGA2 2.0756816987665 3.89026064579331e-12 0.780933228446094 0.0360115182087058 miRanda -0.176732413381176 0.00366766434646306 NA NA NA hsa-miR-374a-5p ITGA2 0.484615721953736 0.0042981729815149 0.780933228446094 0.0360115182087058 MirTarget -0.216061387433447 0.0453053643172189 NA NA NA hsa-miR-374b-5p ITGA2 0.0654362503857184 0.722673188879465 0.780933228446094 0.0360115182087058 MirTarget -0.354406420781692 0.000343325697020091 NA NA NA hsa-miR-497-5p ITGA2 0.0257087130056286 0.918145413833358 0.780933228446094 0.0360115182087058 MirTarget;miRNATAP -0.366207967257797 3.40827962148287e-07 NA NA NA hsa-miR-532-5p ITGA2 1.55697650978597 1.57884735535196e-11 0.780933228446094 0.0360115182087058 MirTarget -0.332666665896713 1.25051690707039e-05 NA NA NA hsa-miR-664a-3p ITGA2 0.634721925861133 0.00520070178640421 0.780933228446094 0.0360115182087058 MirTarget;mirMAP -0.307064501532047 0.000110039333374447 NA NA NA hsa-miR-93-3p ITGA2 2.85383869771942 5.64481766902125e-23 0.780933228446094 0.0360115182087058 MirTarget -0.190076957794452 0.00130315247637948 NA NA NA hsa-miR-127-3p ITGA3 -0.6279281852298 0.0400829468424132 0.852637018409875 0.0199990226143567 PITA -0.252153050401964 1.25908043913737e-05 NA NA NA hsa-miR-129-5p ITGA3 -0.524170159980738 0.222582956006346 0.852637018409875 0.0199990226143567 MirTarget -0.113503125608493 0.00709228458326773 NA NA NA hsa-miR-139-5p ITGA3 -1.52606598644743 1.20474151350665e-08 0.852637018409875 0.0199990226143567 PITA;miRanda -0.264869214195063 4.71452648104517e-05 NA NA NA hsa-miR-199a-3p ITGA3 0.640600337515787 0.0380326905134914 0.852637018409875 0.0199990226143567 MirTarget;PITA;miRNATAP -0.119256547630753 0.0386981201512877 NA NA NA hsa-miR-199a-5p ITGA3 0.592984035153911 0.0674836634175293 0.852637018409875 0.0199990226143567 MirTarget;PITA;miRanda;miRNATAP -0.179017336630157 0.00106876311894462 NA NA NA hsa-miR-199b-3p ITGA3 0.643923492750702 0.0371742251925406 0.852637018409875 0.0199990226143567 MirTarget;PITA;miRNATAP -0.11909154059936 0.0388298818207089 NA NA NA hsa-miR-199b-5p ITGA3 0.218704279044827 0.519493319158441 0.852637018409875 0.0199990226143567 MirTarget;PITA;miRanda;miRNATAP -0.103465501399305 0.0489143240060695 NA NA NA hsa-miR-28-5p ITGA3 0.230152919654905 0.0742909586754846 0.852637018409875 0.0199990226143567 miRanda -0.299073730322259 0.0358545627665129 NA NA NA hsa-miR-326 ITGA3 0.715313016136042 0.0610265683213359 0.852637018409875 0.0199990226143567 miRanda -0.27113229801202 3.67158763009474e-09 NA NA NA hsa-miR-17-5p ITGA4 3.2710598467455 9.93128340539455e-27 -0.728440083514661 0.0524835828399419 TargetScan -0.260479026051391 2.6037508406568e-06 NA NA NA hsa-miR-30c-5p ITGA4 0.778774633108 0.000285599212429136 -0.728440083514661 0.0524835828399419 miRNAWalker2_validate -0.548674109757583 4.16382540319134e-11 NA NA NA hsa-miR-320a ITGA4 0.438165828017084 0.0390159073347133 -0.728440083514661 0.0524835828399419 miRanda -0.452473830481568 1.13821367784972e-07 NA NA NA hsa-miR-320b ITGA4 1.55692969039548 1.41071034251915e-08 -0.728440083514661 0.0524835828399419 miRanda -0.328140674678379 3.86850822533555e-07 NA NA NA hsa-miR-330-5p ITGA4 1.15100069700871 4.85551805046014e-07 -0.728440083514661 0.0524835828399419 miRanda -0.232898030360433 0.0031801231191879 NA NA NA hsa-miR-339-5p ITGA4 2.68710938429893 3.03134080808154e-16 -0.728440083514661 0.0524835828399419 miRanda -0.116822923342213 0.0288025163206776 NA NA NA hsa-miR-107 ITGA5 1.30977326593435 1.30372468603965e-11 -2.12715698251452 2.02033561007737e-09 PITA;miRanda -0.919994926902061 3.13451641182881e-28 NA NA NA hsa-miR-125a-3p ITGA5 1.24490295132072 5.26925231010328e-06 -2.12715698251452 2.02033561007737e-09 miRanda -0.222041291974005 0.000468461148320253 NA NA NA hsa-miR-148a-3p ITGA5 1.26728238710376 2.52325607402829e-06 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.335119735415635 1.46193695086623e-07 NA NA NA hsa-miR-148b-3p ITGA5 1.97815018171325 6.07715327281595e-26 -2.12715698251452 2.02033561007737e-09 miRNAWalker2_validate -1.0908488713867 2.34079592440706e-42 27328731 Notably transendothelial migration in vitro and extravasation in vivo impaired by singly alternating miR-214 or miR-148b could be overridden by overexpression of ITGA5 or ALCAM in the same tumor cells melanoma hsa-miR-183-5p ITGA5 4.19757025992371 4.79612296318304e-26 -2.12715698251452 2.02033561007737e-09 miRNAWalker2_validate -0.526702139503683 4.90437317422702e-46 NA NA NA hsa-miR-185-3p ITGA5 2.3922478518806 1.3373426768452e-14 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.395940119425658 8.90556512571368e-14 NA NA NA hsa-miR-25-3p ITGA5 1.36472605225697 4.83790725935681e-11 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.776199905439916 7.91324957174219e-23 NA NA NA hsa-miR-26b-5p ITGA5 0.885393662798425 3.2116297961629e-06 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.667665635748541 9.09072166745735e-14 NA NA NA hsa-miR-28-5p ITGA5 0.230152919654905 0.0742909586754846 -2.12715698251452 2.02033561007737e-09 PITA;miRanda -0.372501632838063 0.00788860597768604 NA NA NA hsa-miR-3065-3p ITGA5 2.16221780121195 9.65525739884541e-09 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.284226911268234 2.12109019895557e-10 NA NA NA hsa-miR-30c-5p ITGA5 0.778774633108 0.000285599212429136 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.757351411529925 1.84417569669557e-22 NA NA NA hsa-miR-30d-5p ITGA5 0.675423997639582 0.00270618816039773 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.955254954034185 9.2869963961784e-42 NA NA NA hsa-miR-32-5p ITGA5 2.34056473219422 6.24134585974322e-20 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.640757100774878 3.58505029681858e-25 NA NA NA hsa-miR-326 ITGA5 0.715313016136042 0.0610265683213359 -2.12715698251452 2.02033561007737e-09 PITA;miRanda;miRNATAP -0.146729009238172 0.0014084455695614 NA NA NA hsa-miR-330-5p ITGA5 1.15100069700871 4.85551805046014e-07 -2.12715698251452 2.02033561007737e-09 PITA;miRanda;miRNATAP -0.572930453662933 7.70187343692336e-15 27633518 MicroRNA 330 5p negatively regulates ITGA5 expression in human colorectal cancer; These results suggest that downregulation of miR-330-5p expression may affect CRC development via modulation of ITGA5 expression colorectal cancer hsa-miR-429 ITGA5 4.48815175680773 2.44117492218206e-17 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.424089141025183 3.97269444314843e-52 NA NA NA hsa-miR-484 ITGA5 1.81844463411787 1.82951571230938e-15 -2.12715698251452 2.02033561007737e-09 miRNAWalker2_validate -0.626000197827085 1.90555444898923e-18 NA NA NA hsa-miR-629-3p ITGA5 2.36570947321815 1.33458201201618e-11 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.209114467597752 0.000145240794124226 NA NA NA hsa-miR-92a-3p ITGA5 2.06460102658973 1.44784291084757e-19 -2.12715698251452 2.02033561007737e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.738524384643583 1.80680730352447e-26 23499550 The level of miR-92a expression was significantly inversely correlated with ITGA5 expression in various cancer cells; miR-92a overexpression reduced the luciferase activity of the ITGA5 3'-untranslated region suggesting that ITGA5 mRNA is a direct target of miR-92a ovarian cancer hsa-miR-98-5p ITGA5 1.11154309866014 1.24143909012085e-08 -2.12715698251452 2.02033561007737e-09 miRNAWalker2_validate -0.939941795952251 1.16532317725971e-29 NA NA NA hsa-miR-32-3p ITGA6 2.02436999565685 5.94091197945307e-09 -0.212335333681905 0.54809812089726 mirMAP -0.125053790799562 0.0233466106155737 NA NA NA hsa-miR-32-5p ITGA6 2.34056473219422 6.24134585974322e-20 -0.212335333681905 0.54809812089726 miRNAWalker2_validate -0.12876015171195 0.0444432225615113 NA NA NA hsa-miR-125a-5p ITGA7 0.599529391575274 0.0102300147180307 -3.00880253778842 7.00968987324051e-14 miRanda -0.28533355911411 0.000922109444108536 NA NA NA hsa-miR-326 ITGA7 0.715313016136042 0.0610265683213359 -3.00880253778842 7.00968987324051e-14 miRanda -0.106742139616392 0.0434648440415811 NA NA NA hsa-miR-330-5p ITGA7 1.15100069700871 4.85551805046014e-07 -3.00880253778842 7.00968987324051e-14 miRanda -0.671157673153213 1.76126560905712e-15 NA NA NA hsa-miR-339-5p ITGA7 2.68710938429893 3.03134080808154e-16 -3.00880253778842 7.00968987324051e-14 miRanda -0.39334196159986 7.89961842658608e-12 NA NA NA hsa-miR-34c-3p ITGA7 2.41359195938096 3.46966584087088e-10 -3.00880253778842 7.00968987324051e-14 miRNATAP -0.310510251525335 2.49844556322057e-09 NA NA NA hsa-miR-362-3p ITGA7 2.0756816987665 3.89026064579331e-12 -3.00880253778842 7.00968987324051e-14 miRanda -0.23181509775738 0.000595391400199554 NA NA NA hsa-miR-130a-3p ITGA8 2.02021855058359 1.26427102520415e-11 -5.02147349449935 9.74845705778211e-19 mirMAP -0.701148146027453 1.65350333177806e-14 NA NA NA hsa-miR-130b-3p ITGA8 3.5350292994509 1.73934183852569e-27 -5.02147349449935 9.74845705778211e-19 mirMAP -0.652237860058767 3.31744586408737e-16 NA NA NA hsa-miR-16-1-3p ITGA8 2.56983217111073 3.02262181237943e-20 -5.02147349449935 9.74845705778211e-19 mirMAP -0.742157506622875 4.67457957303119e-14 NA NA NA hsa-miR-183-5p ITGA8 4.19757025992371 4.79612296318304e-26 -5.02147349449935 9.74845705778211e-19 miRNAWalker2_validate -0.400283992373764 1.97245511590304e-09 NA NA NA hsa-miR-19b-1-5p ITGA8 2.57951428759379 4.31576118703427e-20 -5.02147349449935 9.74845705778211e-19 mirMAP -0.950433629668659 2.02057554259049e-23 NA NA NA hsa-miR-21-5p ITGA8 2.73773305747971 1.38864982139576e-43 -5.02147349449935 9.74845705778211e-19 mirMAP -1.19403057527354 1.85834943532637e-21 NA NA NA hsa-miR-301a-3p ITGA8 2.81024345929638 2.29784847962242e-17 -5.02147349449935 9.74845705778211e-19 mirMAP -0.64335925433768 5.91211613780249e-14 NA NA NA hsa-miR-30c-5p ITGA8 0.778774633108 0.000285599212429136 -5.02147349449935 9.74845705778211e-19 mirMAP -0.301153651173027 0.0250220558834857 NA NA NA hsa-miR-32-3p ITGA8 2.02436999565685 5.94091197945307e-09 -5.02147349449935 9.74845705778211e-19 mirMAP -0.490500109222766 8.24851799458861e-08 NA NA NA hsa-miR-335-3p ITGA8 3.08791651139852 5.31309869723517e-12 -5.02147349449935 9.74845705778211e-19 mirMAP -0.21654338569711 0.000506229888176448 NA NA NA hsa-miR-33a-5p ITGA8 3.79671563098419 1.15966309820345e-18 -5.02147349449935 9.74845705778211e-19 mirMAP -0.494664035392202 2.80672309130852e-13 NA NA NA hsa-miR-454-3p ITGA8 2.47234127820054 1.12878018736016e-21 -5.02147349449935 9.74845705778211e-19 mirMAP -0.851945857951086 6.14155935624214e-16 NA NA NA hsa-miR-590-5p ITGA8 3.18300989862077 2.06813568597893e-26 -5.02147349449935 9.74845705778211e-19 mirMAP -0.791122075575907 6.02803814138824e-19 NA NA NA hsa-miR-7-1-3p ITGA8 1.84950311431067 1.25300363397654e-13 -5.02147349449935 9.74845705778211e-19 mirMAP -0.857922096684503 2.96714197828025e-15 NA NA NA hsa-miR-944 ITGA8 2.91186649218281 1.31574753528144e-06 -5.02147349449935 9.74845705778211e-19 mirMAP -0.314055170599714 4.17031690283285e-11 NA NA NA hsa-miR-103a-2-5p ITGA9 2.47599305985086 7.933028987326e-11 -2.58466582885052 1.23539072812213e-10 mirMAP -0.333189257281167 4.71225309728939e-09 NA NA NA hsa-miR-125a-5p ITGA9 0.599529391575274 0.0102300147180307 -2.58466582885052 1.23539072812213e-10 MirTarget;PITA;miRanda -0.257555443860711 0.00257708453135463 NA NA NA hsa-miR-141-5p ITGA9 3.81419396518882 3.21977359736126e-18 -2.58466582885052 1.23539072812213e-10 MirTarget -0.382768095787143 3.01801210883476e-20 NA NA NA hsa-miR-181a-5p ITGA9 2.29556023480783 1.8138457900616e-21 -2.58466582885052 1.23539072812213e-10 mirMAP -0.275825886114581 0.000444271124490546 NA NA NA hsa-miR-181b-5p ITGA9 2.49307679431293 3.92829250217627e-20 -2.58466582885052 1.23539072812213e-10 mirMAP -0.26283844200583 0.000168702753369357 NA NA NA hsa-miR-181c-5p ITGA9 1.58587920618301 1.57506918816933e-10 -2.58466582885052 1.23539072812213e-10 mirMAP -0.169272855707109 0.032098734138319 NA NA NA hsa-miR-194-5p ITGA9 1.8992998339217 3.76507853301977e-10 -2.58466582885052 1.23539072812213e-10 miRNAWalker2_validate;miRTarBase -0.239239673825585 0.000188503663699313 NA NA NA hsa-miR-200b-3p ITGA9 3.78235093249346 3.18343003239465e-14 -2.58466582885052 1.23539072812213e-10 mirMAP -0.289128848726961 1.09633928087812e-14 24518294;26334393 β1 integrin inhibition elicits a prometastatic switch through the TGFβ miR 200 ZEB network in E cadherin positive triple negative breast cancer;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ; breast cancer;esophageal cancer hsa-miR-20a-3p ITGA9 2.92621109947706 2.49504904635375e-17 -2.58466582885052 1.23539072812213e-10 mirMAP -0.336092057196259 1.81236614248695e-09 NA NA NA hsa-miR-29a-5p ITGA9 1.46749674755271 3.34605004270294e-07 -2.58466582885052 1.23539072812213e-10 mirMAP -0.245073645324334 0.000685494839373866 26903137 We found that the up-regulation of hTERT in gastric cancer cells could inhibit the expression of miR-29a and enhance the expression of Integrin β1 ITGB1 gastric cancer hsa-miR-29b-1-5p ITGA9 1.55384379072167 4.76870585070176e-05 -2.58466582885052 1.23539072812213e-10 mirMAP -0.184385479316962 0.00074066835452213 NA NA NA hsa-miR-3065-5p ITGA9 2.74629919868982 1.86846589298284e-08 -2.58466582885052 1.23539072812213e-10 mirMAP -0.238324119451079 9.27135266589224e-07 NA NA NA hsa-miR-324-5p ITGA9 2.95683728155095 1.32960514360912e-20 -2.58466582885052 1.23539072812213e-10 miRanda -0.305941658112302 2.17395620809018e-07 NA NA NA hsa-miR-330-3p ITGA9 0.876747334239085 0.00073709016089703 -2.58466582885052 1.23539072812213e-10 mirMAP -0.341495238301213 6.86269977453868e-06 NA NA NA hsa-miR-33a-3p ITGA9 1.72765312072219 1.51784443453521e-07 -2.58466582885052 1.23539072812213e-10 mirMAP -0.21947875085123 0.000795235017755736 NA NA NA hsa-miR-33a-5p ITGA9 3.79671563098419 1.15966309820345e-18 -2.58466582885052 1.23539072812213e-10 mirMAP -0.284694652026791 1.80876365770459e-09 NA NA NA hsa-miR-34c-3p ITGA9 2.41359195938096 3.46966584087088e-10 -2.58466582885052 1.23539072812213e-10 mirMAP -0.240289730425352 3.91172717069565e-06 NA NA NA hsa-miR-429 ITGA9 4.48815175680773 2.44117492218206e-17 -2.58466582885052 1.23539072812213e-10 miRanda -0.270730151616571 8.44416355579571e-15 NA NA NA hsa-miR-452-3p ITGA9 2.42521958420768 4.08754552781156e-07 -2.58466582885052 1.23539072812213e-10 MirTarget -0.237983803331743 4.00039790244819e-09 NA NA NA hsa-miR-452-5p ITGA9 1.37180058737183 0.00171494843537772 -2.58466582885052 1.23539072812213e-10 mirMAP -0.22152461383506 7.41155195215416e-07 NA NA NA hsa-miR-484 ITGA9 1.81844463411787 1.82951571230938e-15 -2.58466582885052 1.23539072812213e-10 miRNAWalker2_validate -0.388080687503693 3.64799786304943e-06 NA NA NA hsa-miR-501-5p ITGA9 1.93654809410041 1.3779381780759e-10 -2.58466582885052 1.23539072812213e-10 MirTarget -0.183252736815145 0.0058645966917876 NA NA NA hsa-miR-576-5p ITGA9 2.20467023993664 3.4053475193793e-19 -2.58466582885052 1.23539072812213e-10 mirMAP -0.583945218998735 8.46239321789068e-15 NA NA NA hsa-miR-589-3p ITGA9 2.51971841868825 2.39125940264107e-11 -2.58466582885052 1.23539072812213e-10 mirMAP -0.284454713999564 9.5711702477892e-07 NA NA NA hsa-miR-590-3p ITGA9 2.59289455139753 1.03200520972022e-21 -2.58466582885052 1.23539072812213e-10 miRanda -0.397900098111868 2.00089620313929e-08 NA NA NA hsa-miR-590-5p ITGA9 3.18300989862077 2.06813568597893e-26 -2.58466582885052 1.23539072812213e-10 miRanda -0.39740570273103 2.79327562565456e-10 NA NA NA hsa-miR-877-5p ITGA9 2.94916202082736 1.8151927276044e-13 -2.58466582885052 1.23539072812213e-10 mirMAP -0.257834392043979 1.67827727756448e-06 NA NA NA hsa-miR-10b-3p ITGAV 0.77597971642517 0.00264877454133753 -0.0552493406333632 0.795714969238101 MirTarget -0.158358641589343 6.69225270139789e-05 NA NA NA hsa-miR-141-3p ITGAV 5.02396127982626 2.19224509139725e-24 -0.0552493406333632 0.795714969238101 MirTarget -0.125634945314397 7.01655633438231e-11 NA NA NA hsa-miR-16-2-3p ITGAV 2.31623086727196 4.29838149388188e-20 -0.0552493406333632 0.795714969238101 mirMAP -0.199617274846503 2.43792627503413e-07 NA NA NA hsa-miR-186-5p ITGAV 1.47445398888668 3.0781726595413e-15 -0.0552493406333632 0.795714969238101 mirMAP -0.359656849104508 8.23776291207508e-12 NA NA NA hsa-miR-192-5p ITGAV 2.69002528723195 1.22990188194432e-16 -0.0552493406333632 0.795714969238101 miRNAWalker2_validate;MirTarget -0.190974902652764 1.81642812826116e-10 NA NA NA hsa-miR-200a-3p ITGAV 4.59434485520731 6.38952518573476e-18 -0.0552493406333632 0.795714969238101 MirTarget -0.131709203257402 2.633117959538e-13 NA NA NA hsa-miR-25-3p ITGAV 1.36472605225697 4.83790725935681e-11 -0.0552493406333632 0.795714969238101 MirTarget;miRNATAP -0.393852941867199 6.6348888648572e-17 NA NA NA hsa-miR-30e-3p ITGAV -0.215663037684509 0.235375122783546 -0.0552493406333632 0.795714969238101 mirMAP -0.339795441635055 1.84221609877849e-09 NA NA NA hsa-miR-32-5p ITGAV 2.34056473219422 6.24134585974322e-20 -0.0552493406333632 0.795714969238101 miRNAWalker2_validate;MirTarget;miRNATAP -0.21813171757581 9.13747743396107e-09 NA NA NA hsa-miR-328-3p ITGAV 0.596804159297544 0.013858523511843 -0.0552493406333632 0.795714969238101 MirTarget -0.184239805543996 1.34681288230083e-05 NA NA NA hsa-miR-331-5p ITGAV 2.17414714166315 1.54547681391888e-18 -0.0552493406333632 0.795714969238101 PITA -0.200744994858149 8.42791176390003e-07 NA NA NA hsa-miR-33a-3p ITGAV 1.72765312072219 1.51784443453521e-07 -0.0552493406333632 0.795714969238101 MirTarget -0.20605161346585 6.47893191633007e-10 NA NA NA hsa-miR-361-5p ITGAV 0.971859117235239 5.30236555707088e-09 -0.0552493406333632 0.795714969238101 MirTarget;miRanda -0.428107639008486 1.15708286730063e-12 NA NA NA hsa-miR-363-3p ITGAV 1.50575300026701 0.00020976164678918 -0.0552493406333632 0.795714969238101 MirTarget -0.108742654034656 1.39301773890387e-05 NA NA NA hsa-miR-374a-5p ITGAV 0.484615721953736 0.0042981729815149 -0.0552493406333632 0.795714969238101 mirMAP -0.234655511836942 0.000126489523100171 NA NA NA hsa-miR-374b-5p ITGAV 0.0654362503857184 0.722673188879465 -0.0552493406333632 0.795714969238101 mirMAP -0.168523506852159 0.00292302259316201 NA NA NA hsa-miR-429 ITGAV 4.48815175680773 2.44117492218206e-17 -0.0552493406333632 0.795714969238101 miRanda -0.127193818759143 2.65456116358475e-12 NA NA NA hsa-miR-576-5p ITGAV 2.20467023993664 3.4053475193793e-19 -0.0552493406333632 0.795714969238101 PITA;mirMAP -0.196724599850144 7.64027152189049e-07 NA NA NA hsa-miR-582-3p ITGAV 0.00876844181512659 0.977126166214707 -0.0552493406333632 0.795714969238101 MirTarget -0.126654225661071 0.00016778168578043 NA NA NA hsa-miR-589-3p ITGAV 2.51971841868825 2.39125940264107e-11 -0.0552493406333632 0.795714969238101 MirTarget -0.126299636648124 2.84553241173989e-05 NA NA NA hsa-miR-590-3p ITGAV 2.59289455139753 1.03200520972022e-21 -0.0552493406333632 0.795714969238101 MirTarget;PITA;miRanda -0.192092523174197 1.80193428945462e-07 NA NA NA hsa-miR-7-1-3p ITGAV 1.84950311431067 1.25300363397654e-13 -0.0552493406333632 0.795714969238101 mirMAP -0.236895615730496 2.11030326941029e-09 NA NA NA hsa-miR-92a-3p ITGAV 2.06460102658973 1.44784291084757e-19 -0.0552493406333632 0.795714969238101 MirTarget;miRNATAP -0.311573118807097 1.56062452922841e-13 NA NA NA hsa-miR-140-3p ITGB1 0.0608890720479334 0.727716871248724 -0.317990264846452 0.0583538962479715 PITA -0.152968161799928 0.00116014308129053 NA NA NA hsa-miR-16-2-3p ITGB1 2.31623086727196 4.29838149388188e-20 -0.317990264846452 0.0583538962479715 mirMAP -0.141160608447208 3.85032895815224e-06 NA NA NA hsa-miR-183-5p ITGB1 4.19757025992371 4.79612296318304e-26 -0.317990264846452 0.0583538962479715 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.112552819137231 2.29750481257299e-09 NA NA NA hsa-miR-186-5p ITGB1 1.47445398888668 3.0781726595413e-15 -0.317990264846452 0.0583538962479715 miRNAWalker2_validate -0.220899040075317 1.36892502161787e-07 NA NA NA hsa-miR-192-5p ITGB1 2.69002528723195 1.22990188194432e-16 -0.317990264846452 0.0583538962479715 miRNAWalker2_validate -0.126909312363049 9.28728124283711e-08 NA NA NA hsa-miR-25-3p ITGB1 1.36472605225697 4.83790725935681e-11 -0.317990264846452 0.0583538962479715 miRNAWalker2_validate -0.236874100330584 3.73108051799375e-10 NA NA NA hsa-miR-29b-3p ITGB1 1.65828197923813 1.02676780888141e-09 -0.317990264846452 0.0583538962479715 MirTarget;miRNATAP -0.10958332671188 0.00018022560545176 NA NA NA hsa-miR-29c-3p ITGB1 -0.00968972577705429 0.97099586346872 -0.317990264846452 0.0583538962479715 MirTarget;miRNATAP -0.213633384526717 8.03067259735927e-13 26766915 MiR 29c inhibits cell growth invasion and migration of pancreatic cancer by targeting ITGB1; Further analysis revealed that ITGB1 is one of the functional target genes of miR-29c and knockdown of ITGB1 inhibited the proliferation migration and invasion of PC cells which was similar to the effects of overexpression of miR-29c pancreatic cancer hsa-miR-320a ITGB1 0.438165828017084 0.0390159073347133 -0.317990264846452 0.0583538962479715 miRanda -0.184906998403177 1.25967988130064e-06 NA NA NA hsa-miR-320b ITGB1 1.55692969039548 1.41071034251915e-08 -0.317990264846452 0.0583538962479715 miRanda -0.1239407118418 1.87342985560011e-05 NA NA NA hsa-miR-374b-3p ITGB1 0.930487774873495 2.74420094310516e-05 -0.317990264846452 0.0583538962479715 MirTarget -0.133594836312993 0.000254936674249418 NA NA NA hsa-miR-429 ITGB1 4.48815175680773 2.44117492218206e-17 -0.317990264846452 0.0583538962479715 miRanda -0.109929733310157 1.15161131378325e-14 NA NA NA hsa-miR-590-3p ITGB1 2.59289455139753 1.03200520972022e-21 -0.317990264846452 0.0583538962479715 miRanda;mirMAP -0.161045941493014 2.61134487020392e-08 NA NA NA hsa-miR-590-5p ITGB1 3.18300989862077 2.06813568597893e-26 -0.317990264846452 0.0583538962479715 miRanda -0.131829234680063 3.6025921225854e-07 NA NA NA hsa-miR-7-1-3p ITGB1 1.84950311431067 1.25300363397654e-13 -0.317990264846452 0.0583538962479715 MirTarget;mirMAP -0.143757573933581 4.81116164603926e-06 NA NA NA hsa-miR-769-5p ITGB1 1.82023760596845 9.6815886564134e-14 -0.317990264846452 0.0583538962479715 miRNAWalker2_validate -0.178309859576212 2.27127944360586e-08 NA NA NA hsa-let-7a-5p ITGB3 0.618599506841644 2.76973453058748e-05 -2.36514018822678 1.11882034713806e-07 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.989245528826512 1.82973539199889e-11 NA NA NA hsa-let-7b-5p ITGB3 0.604314269683977 0.00140009936153214 -2.36514018822678 1.11882034713806e-07 MirTarget;miRNATAP -0.614334197884385 9.78072145525659e-08 NA NA NA hsa-let-7d-5p ITGB3 1.33236798905207 1.1741085658466e-13 -2.36514018822678 1.11882034713806e-07 MirTarget -0.972385555315623 3.86209598663812e-17 NA NA NA hsa-let-7e-5p ITGB3 0.860104282510173 6.04758298373779e-05 -2.36514018822678 1.11882034713806e-07 MirTarget;miRNATAP -0.438073178533302 1.59192858914311e-05 NA NA NA hsa-let-7f-5p ITGB3 0.495648727272215 0.00355972741198794 -2.36514018822678 1.11882034713806e-07 MirTarget;miRNATAP -0.584915121205566 6.23747436408235e-06 NA NA NA hsa-let-7g-5p ITGB3 1.20061455355116 1.50237505511483e-12 -2.36514018822678 1.11882034713806e-07 MirTarget;miRNATAP -1.17761218427917 2.59918555748576e-22 NA NA NA hsa-miR-185-5p ITGB3 2.34016206907488 1.17481626642022e-26 -2.36514018822678 1.11882034713806e-07 MirTarget -0.69383888203154 3.95451850131206e-14 NA NA NA hsa-miR-186-5p ITGB3 1.47445398888668 3.0781726595413e-15 -2.36514018822678 1.11882034713806e-07 mirMAP -0.877206422678023 2.55789916386277e-15 NA NA NA hsa-miR-18a-3p ITGB3 2.14813400940323 2.23460809936028e-06 -2.36514018822678 1.11882034713806e-07 miRNATAP -0.224657603872067 0.000182579378919658 NA NA NA hsa-miR-1976 ITGB3 2.06550563678192 7.81396978619772e-18 -2.36514018822678 1.11882034713806e-07 MirTarget -0.600731909510262 2.64114704093274e-12 NA NA NA hsa-miR-28-5p ITGB3 0.230152919654905 0.0742909586754846 -2.36514018822678 1.11882034713806e-07 miRanda -0.505515973751828 0.00392489144918646 NA NA NA hsa-miR-30b-5p ITGB3 0.800822374912712 0.000133601914525413 -2.36514018822678 1.11882034713806e-07 mirMAP -0.724774757198107 1.23727568515502e-12 20498642 Enforced constitutive expression of mir-30 in BT-ICs inhibits their self-renewal capacity by reducing Ubc9 and induces apoptosis through silencing ITGB3 breast cancer hsa-miR-30c-5p ITGB3 0.778774633108 0.000285599212429136 -2.36514018822678 1.11882034713806e-07 miRNAWalker2_validate;mirMAP;miRNATAP -0.853248091943228 3.89651966097134e-18 NA NA NA hsa-miR-30d-5p ITGB3 0.675423997639582 0.00270618816039773 -2.36514018822678 1.11882034713806e-07 miRNATAP -0.79173776067464 3.80614379408852e-17 NA NA NA hsa-miR-320a ITGB3 0.438165828017084 0.0390159073347133 -2.36514018822678 1.11882034713806e-07 miRanda -0.795988187522278 2.65520563222487e-15 NA NA NA hsa-miR-320b ITGB3 1.55692969039548 1.41071034251915e-08 -2.36514018822678 1.11882034713806e-07 miRanda -0.644642166125784 1.74012028319029e-17 NA NA NA hsa-miR-3607-3p ITGB3 2.68532138541128 5.66716351955047e-14 -2.36514018822678 1.11882034713806e-07 MirTarget;mirMAP;miRNATAP -0.442398977697993 9.08925492991088e-14 NA NA NA hsa-miR-425-5p ITGB3 3.07071373939774 4.02947460586085e-25 -2.36514018822678 1.11882034713806e-07 MirTarget -0.674667852485928 1.2118842361245e-24 NA NA NA hsa-miR-429 ITGB3 4.48815175680773 2.44117492218206e-17 -2.36514018822678 1.11882034713806e-07 miRanda -0.459266250119302 1.10022358528139e-36 NA NA NA hsa-miR-589-5p ITGB3 1.71990116752371 8.310889042056e-14 -2.36514018822678 1.11882034713806e-07 MirTarget -0.334615923322686 0.000295181496585407 NA NA NA hsa-miR-590-3p ITGB3 2.59289455139753 1.03200520972022e-21 -2.36514018822678 1.11882034713806e-07 PITA;miRanda -0.500125186389998 1.1740515245078e-10 NA NA NA hsa-miR-590-5p ITGB3 3.18300989862077 2.06813568597893e-26 -2.36514018822678 1.11882034713806e-07 miRanda -0.565339284148694 1.14587741951889e-16 NA NA NA hsa-miR-98-5p ITGB3 1.11154309866014 1.24143909012085e-08 -2.36514018822678 1.11882034713806e-07 miRNAWalker2_validate;MirTarget -0.835488358881533 1.08310398420676e-14 26445551 miR 98 targets ITGB3 to inhibit proliferation migration and invasion of non small cell lung cancer; Furthermore we identified that miR-98 exerted inhibitory roles by directly binding to 3'-UTR of ITGB3 mRNA thus negatively regulated the expression of ITGB3; Interestingly upon restoring the expression of ITGB3 the effect of miR-98 on cell proliferation was partially reversed; Our findings suggest that miR-98 prevents proliferation migration and invasion of lung cancer cells by directly binding to the 3'-UTR of ITGB3 mRNA and could be a promising treatment option in anticancer therapy lung squamous cell cancer hsa-miR-532-5p ITGB4 1.55697650978597 1.57884735535196e-11 1.10431203462344 0.00240847857883416 miRNATAP -0.25594611351957 0.00063709838812017 NA NA NA hsa-miR-335-5p ITGB5 1.77247705492746 2.22457658872091e-06 0.0659632945181734 0.782072361855164 miRNAWalker2_validate -0.116318527732458 0.000119850401605925 NA NA NA hsa-miR-361-5p ITGB5 0.971859117235239 5.30236555707088e-09 0.0659632945181734 0.782072361855164 miRanda -0.370854793541912 5.23628556596546e-08 NA NA NA hsa-miR-378a-5p ITGB5 0.223456081148306 0.386368843153575 0.0659632945181734 0.782072361855164 MirTarget -0.339918050815375 5.45226214614412e-15 NA NA NA hsa-miR-421 ITGB5 1.17791565395543 6.78526676976629e-06 0.0659632945181734 0.782072361855164 miRanda;miRNATAP -0.206863182915145 1.90179639014605e-06 NA NA NA hsa-miR-484 ITGB5 1.81844463411787 1.82951571230938e-15 0.0659632945181734 0.782072361855164 miRNATAP -0.222390468841951 4.59175532460192e-06 NA NA NA hsa-miR-486-5p ITGB5 -0.194913133034028 0.607377798807705 0.0659632945181734 0.782072361855164 miRanda -0.102224900608579 0.000744091379292665 NA NA NA hsa-miR-338-5p ITGB6 -0.577691606146419 0.0472212680542825 2.78219765894116 1.75801053874479e-07 mirMAP -0.225946185124269 0.0129098977602992 NA NA NA hsa-miR-106b-5p ITGB8 2.46782146831112 1.36171495805632e-23 -0.771536596399464 0.078204531928335 MirTarget;miRNATAP -0.243858394600342 0.00282140797809879 NA NA NA hsa-miR-130b-3p ITGB8 3.5350292994509 1.73934183852569e-27 -0.771536596399464 0.078204531928335 MirTarget;miRNATAP -0.150321524620852 0.0138933037989529 NA NA NA hsa-miR-148a-3p ITGB8 1.26728238710376 2.52325607402829e-06 -0.771536596399464 0.078204531928335 miRNATAP -0.167845143612394 0.0320375495476014 NA NA NA hsa-miR-17-5p ITGB8 3.2710598467455 9.93128340539455e-27 -0.771536596399464 0.078204531928335 MirTarget;TargetScan;miRNATAP -0.128521737377887 0.0491079441807915 NA NA NA hsa-miR-182-5p ITGB8 3.53923166221814 5.07781258121574e-21 -0.771536596399464 0.078204531928335 MirTarget -0.165583568981071 0.00199407237884609 NA NA NA hsa-miR-183-5p ITGB8 4.19757025992371 4.79612296318304e-26 -0.771536596399464 0.078204531928335 MirTarget -0.133547226997407 0.00765809779443789 NA NA NA hsa-miR-200a-3p ITGB8 4.59434485520731 6.38952518573476e-18 -0.771536596399464 0.078204531928335 MirTarget -0.112669132633583 0.00309179364519111 NA NA NA hsa-miR-20a-5p ITGB8 3.15577933619191 4.19753346442454e-25 -0.771536596399464 0.078204531928335 MirTarget;miRNATAP -0.155166421987352 0.0181596501694646 NA NA NA hsa-miR-301a-3p ITGB8 2.81024345929638 2.29784847962242e-17 -0.771536596399464 0.078204531928335 MirTarget;miRNATAP -0.200093872640416 0.00207569672910553 NA NA NA hsa-miR-3607-3p ITGB8 2.68532138541128 5.66716351955047e-14 -0.771536596399464 0.078204531928335 MirTarget;miRNATAP -0.167997017462967 0.00447754184008363 NA NA NA hsa-miR-361-5p ITGB8 0.971859117235239 5.30236555707088e-09 -0.771536596399464 0.078204531928335 miRanda -0.32801342045249 0.0099397274265615 NA NA NA hsa-miR-429 ITGB8 4.48815175680773 2.44117492218206e-17 -0.771536596399464 0.078204531928335 miRNATAP -0.100769088742544 0.00866111495137325 NA NA NA hsa-miR-454-3p ITGB8 2.47234127820054 1.12878018736016e-21 -0.771536596399464 0.078204531928335 MirTarget -0.240534765314581 0.00276010353600829 NA NA NA hsa-miR-532-5p ITGB8 1.55697650978597 1.57884735535196e-11 -0.771536596399464 0.078204531928335 PITA -0.252012563669139 0.00516420917739492 NA NA NA hsa-miR-582-5p ITGB8 0.609226359812689 0.032988717891497 -0.771536596399464 0.078204531928335 miRNATAP -0.15433629363714 0.0382905750008405 NA NA NA hsa-miR-93-5p ITGB8 3.03961860136032 1.11672209617395e-24 -0.771536596399464 0.078204531928335 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.283928984292905 2.37537782426909e-05 NA NA NA hsa-let-7g-3p JAK1 3.26398061402445 3.96263126107645e-25 -0.647144039203939 3.25551149817466e-06 MirTarget -0.160173599472765 1.98343469212566e-15 NA NA NA hsa-miR-106a-5p JAK1 2.48882002962836 1.99757727374521e-12 -0.647144039203939 3.25551149817466e-06 MirTarget -0.133261991596329 2.08270266659009e-13 NA NA NA hsa-miR-106b-5p JAK1 2.46782146831112 1.36171495805632e-23 -0.647144039203939 3.25551149817466e-06 miRNAWalker2_validate;MirTarget -0.270448677438555 1.81937362986755e-28 NA NA NA hsa-miR-128-3p JAK1 1.63756041666078 6.79626586407187e-14 -0.647144039203939 3.25551149817466e-06 miRNAWalker2_validate -0.23450814388999 1.21522000897489e-15 NA NA NA hsa-miR-15b-5p JAK1 1.57112623124278 9.14247846750597e-13 -0.647144039203939 3.25551149817466e-06 miRNAWalker2_validate -0.202388635992569 6.7540767380457e-12 NA NA NA hsa-miR-17-5p JAK1 3.2710598467455 9.93128340539455e-27 -0.647144039203939 3.25551149817466e-06 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.190095912387356 9.24241683512841e-22 NA NA NA hsa-miR-20a-5p JAK1 3.15577933619191 4.19753346442454e-25 -0.647144039203939 3.25551149817466e-06 MirTarget -0.19658594535312 5.11615429760049e-23 NA NA NA hsa-miR-28-5p JAK1 0.230152919654905 0.0742909586754846 -0.647144039203939 3.25551149817466e-06 miRanda;miRNATAP -0.170979664648501 0.00160634337684464 NA NA NA hsa-miR-30b-5p JAK1 0.800822374912712 0.000133601914525413 -0.647144039203939 3.25551149817466e-06 MirTarget -0.161576536892966 4.64284555422181e-07 NA NA NA hsa-miR-30c-5p JAK1 0.778774633108 0.000285599212429136 -0.647144039203939 3.25551149817466e-06 MirTarget -0.201102336728054 8.89538183624433e-11 NA NA NA hsa-miR-30d-5p JAK1 0.675423997639582 0.00270618816039773 -0.647144039203939 3.25551149817466e-06 MirTarget -0.154865436420283 2.14924883319783e-07 NA NA NA hsa-miR-30e-5p JAK1 1.23904909539663 1.35561917122157e-09 -0.647144039203939 3.25551149817466e-06 MirTarget -0.230082866037824 6.16026755354551e-13 NA NA NA hsa-miR-421 JAK1 1.17791565395543 6.78526676976629e-06 -0.647144039203939 3.25551149817466e-06 miRanda -0.147691711558544 6.10849726240234e-09 NA NA NA hsa-miR-93-5p JAK1 3.03961860136032 1.11672209617395e-24 -0.647144039203939 3.25551149817466e-06 MirTarget;miRNATAP -0.231847990523344 8.3596082797108e-31 NA NA NA hsa-miR-181b-5p JAK2 2.49307679431293 3.92829250217627e-20 -1.15591014116351 2.41377836157725e-06 mirMAP -0.126298321939292 0.00280279169548862 NA NA NA hsa-miR-320a JAK2 0.438165828017084 0.0390159073347133 -1.15591014116351 2.41377836157725e-06 miRanda -0.261791495849082 3.53850703335005e-06 NA NA NA hsa-miR-320b JAK2 1.55692969039548 1.41071034251915e-08 -1.15591014116351 2.41377836157725e-06 miRanda -0.192414825001941 6.78364550897638e-06 NA NA NA hsa-miR-335-5p JAK2 1.77247705492746 2.22457658872091e-06 -1.15591014116351 2.41377836157725e-06 miRNAWalker2_validate -0.139827980201026 8.49568099995058e-06 NA NA NA hsa-miR-337-3p JAK2 -0.411177775367481 0.195619700046772 -1.15591014116351 2.41377836157725e-06 PITA -0.120338259347987 0.00143569843122572 NA NA NA hsa-miR-374a-5p JAK2 0.484615721953736 0.0042981729815149 -1.15591014116351 2.41377836157725e-06 mirMAP -0.216962490817654 0.00241367009160665 NA NA NA hsa-miR-7-1-3p JAK2 1.84950311431067 1.25300363397654e-13 -1.15591014116351 2.41377836157725e-06 mirMAP -0.126192940113873 0.00705546310328513 NA NA NA hsa-miR-185-3p JAK3 2.3922478518806 1.3373426768452e-14 0.239319633198264 0.412693129074947 MirTarget -0.130400514948531 0.00304758139838244 NA NA NA hsa-miR-3065-5p JAK3 2.74629919868982 1.86846589298284e-08 0.239319633198264 0.412693129074947 MirTarget;mirMAP -0.145493467816477 2.62398563869512e-05 NA NA NA hsa-miR-30b-3p JAK3 0.834142820354026 0.000972582820878813 0.239319633198264 0.412693129074947 MirTarget -0.340344181521277 6.48798336220165e-10 NA NA NA hsa-miR-320b JAK3 1.55692969039548 1.41071034251915e-08 0.239319633198264 0.412693129074947 miRanda -0.124107097041574 0.0144841788065049 NA NA NA hsa-miR-421 JAK3 1.17791565395543 6.78526676976629e-06 0.239319633198264 0.412693129074947 miRanda -0.193934751106983 0.000292909648252411 NA NA NA hsa-miR-15a-5p KDR 2.34669284378787 1.69544424500258e-23 -0.809645188569233 0.00140156336172476 miRNATAP -0.127736253549545 0.0104134262261477 NA NA NA hsa-miR-15b-5p KDR 1.57112623124278 9.14247846750597e-13 -0.809645188569233 0.00140156336172476 miRNATAP -0.155621687078152 0.0045182683141369 NA NA NA hsa-miR-16-5p KDR 1.75824877145857 1.68592440033108e-16 -0.809645188569233 0.00140156336172476 miRTarBase;miRNATAP -0.182939670656605 0.00106812366151133 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2 colorectal cancer hsa-miR-19b-1-5p KDR 2.57951428759379 4.31576118703427e-20 -0.809645188569233 0.00140156336172476 miRNAWalker2_validate -0.229520229616341 6.75997699685035e-08 NA NA NA hsa-miR-200c-3p KDR 3.50132673580082 2.42716349086937e-15 -0.809645188569233 0.00140156336172476 miRNATAP -0.100553706909197 0.000169957263481419 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-23a-3p KDR 1.00493340843378 2.55313889288924e-08 -0.809645188569233 0.00140156336172476 mirMAP -0.286683208573693 2.23043040222106e-05 NA NA NA hsa-miR-3065-3p KDR 2.16221780121195 9.65525739884541e-09 -0.809645188569233 0.00140156336172476 miRNATAP -0.115781865974172 0.00029357167187714 NA NA NA hsa-miR-455-5p KDR 2.2582442061694 1.43472128037398e-13 -0.809645188569233 0.00140156336172476 PITA;miRanda;miRNATAP -0.148297955432885 0.000143983958437006 NA NA NA hsa-miR-590-3p KDR 2.59289455139753 1.03200520972022e-21 -0.809645188569233 0.00140156336172476 miRanda -0.18919157083552 1.89718911518431e-05 NA NA NA hsa-miR-590-5p KDR 3.18300989862077 2.06813568597893e-26 -0.809645188569233 0.00140156336172476 miRanda -0.161280644562926 4.49661990812652e-05 NA NA NA hsa-let-7a-3p KIT 1.42015538786275 7.03375209382654e-13 -2.52159771280238 8.03290749995369e-07 mirMAP -0.305660969251931 0.0140590843625152 NA NA NA hsa-let-7b-3p KIT 0.868207752019623 1.30460056774366e-05 -2.52159771280238 8.03290749995369e-07 mirMAP -0.258005222215759 0.0408367839447639 NA NA NA hsa-let-7f-1-3p KIT 1.55054488387679 7.31326775537952e-11 -2.52159771280238 8.03290749995369e-07 mirMAP -0.668445729598711 1.51130372139265e-10 NA NA NA hsa-miR-125a-3p KIT 1.24490295132072 5.26925231010328e-06 -2.52159771280238 8.03290749995369e-07 miRanda -0.255118298636462 0.00509486668847337 NA NA NA hsa-miR-128-3p KIT 1.63756041666078 6.79626586407187e-14 -2.52159771280238 8.03290749995369e-07 MirTarget -0.254012696257536 0.0234658488003705 NA NA NA hsa-miR-130a-3p KIT 2.02021855058359 1.26427102520415e-11 -2.52159771280238 8.03290749995369e-07 miRNATAP -0.466185309570644 8.0802122737332e-09 NA NA NA hsa-miR-130b-3p KIT 3.5350292994509 1.73934183852569e-27 -2.52159771280238 8.03290749995369e-07 miRNATAP -0.363470477280817 3.49115745986817e-07 NA NA NA hsa-miR-142-5p KIT 1.17581605694506 0.0018174701991234 -2.52159771280238 8.03290749995369e-07 PITA;miRNATAP -0.366729686646503 1.87812939014732e-08 NA NA NA hsa-miR-146b-5p KIT 1.75587235896724 1.15724631266659e-07 -2.52159771280238 8.03290749995369e-07 miRNAWalker2_validate -0.416813589432571 1.42119994915586e-08 NA NA NA hsa-miR-186-5p KIT 1.47445398888668 3.0781726595413e-15 -2.52159771280238 8.03290749995369e-07 miRNAWalker2_validate -0.659172130461391 3.65526184071893e-07 NA NA NA hsa-miR-193a-3p KIT 1.60460546928078 2.86169793322984e-07 -2.52159771280238 8.03290749995369e-07 MirTarget;PITA;miRanda;miRNATAP -0.488922632123506 3.08444759163985e-10 NA NA NA hsa-miR-193b-3p KIT 2.25711804611899 4.1940744806631e-14 -2.52159771280238 8.03290749995369e-07 MirTarget;miRNATAP -0.689620638977969 1.08764423044794e-18 NA NA NA hsa-miR-19a-3p KIT 3.42309334186656 3.02671914353412e-28 -2.52159771280238 8.03290749995369e-07 miRTarBase;miRNATAP -0.492359170089366 2.58837661846889e-11 NA NA NA hsa-miR-19b-3p KIT 2.49529833021187 1.57028265846699e-23 -2.52159771280238 8.03290749995369e-07 miRNATAP -0.605758711501565 8.90523497903026e-11 NA NA NA hsa-miR-205-5p KIT 4.1389800495524 2.05488295686453e-12 -2.52159771280238 8.03290749995369e-07 miRNATAP -0.156777960092351 0.000138207674163266 NA NA NA hsa-miR-20a-5p KIT 3.15577933619191 4.19753346442454e-25 -2.52159771280238 8.03290749995369e-07 miRTarBase -0.457576168379078 1.92521778037074e-09 NA NA NA hsa-miR-221-3p KIT 0.451556679024397 0.0909808299917811 -2.52159771280238 8.03290749995369e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.405149427467833 1.47261328620332e-05 NA NA NA hsa-miR-222-3p KIT 0.851783756239071 0.00266783568486918 -2.52159771280238 8.03290749995369e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.471589014167227 6.25441385275748e-08 NA NA NA hsa-miR-301a-3p KIT 2.81024345929638 2.29784847962242e-17 -2.52159771280238 8.03290749995369e-07 miRNATAP -0.359299688669289 2.40561125535435e-06 NA NA NA hsa-miR-3065-5p KIT 2.74629919868982 1.86846589298284e-08 -2.52159771280238 8.03290749995369e-07 miRNATAP -0.239450501478508 9.93041712635943e-05 NA NA NA hsa-miR-338-3p KIT 0.453166438193782 0.144583389707558 -2.52159771280238 8.03290749995369e-07 miRanda -0.213122500667458 0.0083854475397935 NA NA NA hsa-miR-342-3p KIT 1.49115144672245 1.43879249744621e-07 -2.52159771280238 8.03290749995369e-07 miRanda -0.498555598512948 6.78222503737131e-09 NA NA NA hsa-miR-34a-5p KIT 1.9016323452565 1.43092834643601e-14 -2.52159771280238 8.03290749995369e-07 MirTarget -0.312332886384761 0.00150658023755356 NA NA NA hsa-miR-421 KIT 1.17791565395543 6.78526676976629e-06 -2.52159771280238 8.03290749995369e-07 miRanda -0.238395717019672 0.0124890153451638 NA NA NA hsa-miR-450b-5p KIT 1.69244418548325 1.68064054148881e-10 -2.52159771280238 8.03290749995369e-07 MirTarget -0.255623321466667 0.00589465358679959 NA NA NA hsa-miR-454-3p KIT 2.47234127820054 1.12878018736016e-21 -2.52159771280238 8.03290749995369e-07 miRNATAP -0.486460410383953 2.23308592991569e-07 NA NA NA hsa-miR-501-5p KIT 1.93654809410041 1.3779381780759e-10 -2.52159771280238 8.03290749995369e-07 miRNATAP -0.330857176667494 7.26551506682279e-05 NA NA NA hsa-miR-505-3p KIT 1.45322244209148 8.86597629645867e-10 -2.52159771280238 8.03290749995369e-07 MirTarget;miRNATAP -0.371944509463907 0.000339794987685505 NA NA NA hsa-miR-590-3p KIT 2.59289455139753 1.03200520972022e-21 -2.52159771280238 8.03290749995369e-07 miRanda;mirMAP -0.519087288164396 5.92119981865176e-09 NA NA NA hsa-miR-671-5p KIT 2.97733652243246 1.21148452344738e-23 -2.52159771280238 8.03290749995369e-07 MirTarget -0.454665071801787 4.95785958848314e-08 NA NA NA hsa-miR-126-5p KITLG 0.895338176458417 2.33372756450713e-05 -1.58421888595384 1.26958469493711e-05 mirMAP -0.272908961885384 0.00109791686862477 NA NA NA hsa-miR-17-3p KITLG 2.2704817679209 1.1667437320211e-22 -1.58421888595384 1.26958469493711e-05 MirTarget -0.393101365022262 4.72483145331596e-08 NA NA NA hsa-miR-181a-5p KITLG 2.29556023480783 1.8138457900616e-21 -1.58421888595384 1.26958469493711e-05 MirTarget -0.335550426249135 1.41658817648335e-06 NA NA NA hsa-miR-181b-5p KITLG 2.49307679431293 3.92829250217627e-20 -1.58421888595384 1.26958469493711e-05 MirTarget -0.256299176970811 3.77948441551811e-05 NA NA NA hsa-miR-181c-5p KITLG 1.58587920618301 1.57506918816933e-10 -1.58421888595384 1.26958469493711e-05 MirTarget -0.375267300888401 6.43592855187612e-08 NA NA NA hsa-miR-181d-5p KITLG 1.52204912185579 9.2693319057748e-08 -1.58421888595384 1.26958469493711e-05 MirTarget -0.278757212609034 4.95980714874251e-06 NA NA NA hsa-miR-185-5p KITLG 2.34016206907488 1.17481626642022e-26 -1.58421888595384 1.26958469493711e-05 miRNAWalker2_validate -0.497221789302377 3.08433724856098e-11 NA NA NA hsa-miR-186-5p KITLG 1.47445398888668 3.0781726595413e-15 -1.58421888595384 1.26958469493711e-05 mirMAP -0.634325234856109 2.3833607940713e-12 NA NA NA hsa-miR-188-5p KITLG 2.52825126596644 6.78099435999778e-14 -1.58421888595384 1.26958469493711e-05 MirTarget -0.158300742158382 0.00356546035156523 NA NA NA hsa-miR-19a-3p KITLG 3.42309334186656 3.02671914353412e-28 -1.58421888595384 1.26958469493711e-05 mirMAP -0.295616865695893 1.97462506125613e-08 NA NA NA hsa-miR-19b-3p KITLG 2.49529833021187 1.57028265846699e-23 -1.58421888595384 1.26958469493711e-05 mirMAP -0.413630495127345 4.24005211940184e-10 NA NA NA hsa-miR-205-5p KITLG 4.1389800495524 2.05488295686453e-12 -1.58421888595384 1.26958469493711e-05 mirMAP -0.117072550460012 5.69160994612424e-05 NA NA NA hsa-miR-26b-5p KITLG 0.885393662798425 3.2116297961629e-06 -1.58421888595384 1.26958469493711e-05 mirMAP -0.563591788866142 7.88944359372229e-10 NA NA NA hsa-miR-3065-5p KITLG 2.74629919868982 1.86846589298284e-08 -1.58421888595384 1.26958469493711e-05 mirMAP -0.106524272381228 0.0149647503913702 NA NA NA hsa-miR-30b-5p KITLG 0.800822374912712 0.000133601914525413 -1.58421888595384 1.26958469493711e-05 mirMAP -0.373437144222724 9.06999703155285e-06 NA NA NA hsa-miR-30c-5p KITLG 0.778774633108 0.000285599212429136 -1.58421888595384 1.26958469493711e-05 mirMAP -0.489316558126056 1.8498271253835e-09 NA NA NA hsa-miR-30d-3p KITLG 0.977747550180601 4.3048212205381e-05 -1.58421888595384 1.26958469493711e-05 MirTarget -0.445191677600574 9.67622181853915e-10 NA NA NA hsa-miR-30d-5p KITLG 0.675423997639582 0.00270618816039773 -1.58421888595384 1.26958469493711e-05 mirMAP -0.466126096391756 1.99145566818422e-09 NA NA NA hsa-miR-30e-3p KITLG -0.215663037684509 0.235375122783546 -1.58421888595384 1.26958469493711e-05 MirTarget -0.382077752173622 0.000105770526649688 NA NA NA hsa-miR-30e-5p KITLG 1.23904909539663 1.35561917122157e-09 -1.58421888595384 1.26958469493711e-05 mirMAP -0.732751398239663 5.51580529001383e-19 NA NA NA hsa-miR-32-3p KITLG 2.02436999565685 5.94091197945307e-09 -1.58421888595384 1.26958469493711e-05 mirMAP -0.268247170000525 2.19511785328886e-06 NA NA NA hsa-miR-320a KITLG 0.438165828017084 0.0390159073347133 -1.58421888595384 1.26958469493711e-05 MirTarget;PITA;miRanda -0.332443568739992 7.2431289530736e-05 NA NA NA hsa-miR-320b KITLG 1.55692969039548 1.41071034251915e-08 -1.58421888595384 1.26958469493711e-05 MirTarget;PITA;miRanda -0.298318886485037 2.31418090290057e-06 NA NA NA hsa-miR-330-3p KITLG 0.876747334239085 0.00073709016089703 -1.58421888595384 1.26958469493711e-05 MirTarget -0.354367135933503 1.46321487291767e-07 NA NA NA hsa-miR-335-3p KITLG 3.08791651139852 5.31309869723517e-12 -1.58421888595384 1.26958469493711e-05 MirTarget -0.21504425067243 1.48720706250474e-08 NA NA NA hsa-miR-33a-3p KITLG 1.72765312072219 1.51784443453521e-07 -1.58421888595384 1.26958469493711e-05 mirMAP -0.268144639312142 3.77355330121851e-06 NA NA NA hsa-miR-345-5p KITLG 3.63532310411307 2.2698112107996e-21 -1.58421888595384 1.26958469493711e-05 MirTarget -0.283518391479385 4.6913558863265e-11 NA NA NA hsa-miR-34a-5p KITLG 1.9016323452565 1.43092834643601e-14 -1.58421888595384 1.26958469493711e-05 MirTarget -0.471477676973797 4.5117297895647e-12 NA NA NA hsa-miR-374a-5p KITLG 0.484615721953736 0.0042981729815149 -1.58421888595384 1.26958469493711e-05 mirMAP -0.21860765447886 0.0392947097462615 NA NA NA hsa-miR-450b-5p KITLG 1.69244418548325 1.68064054148881e-10 -1.58421888595384 1.26958469493711e-05 MirTarget;PITA;mirMAP -0.163249316952384 0.013044495513343 NA NA NA hsa-miR-501-5p KITLG 1.93654809410041 1.3779381780759e-10 -1.58421888595384 1.26958469493711e-05 PITA;mirMAP -0.197041237116664 0.000870835645630206 NA NA NA hsa-miR-589-3p KITLG 2.51971841868825 2.39125940264107e-11 -1.58421888595384 1.26958469493711e-05 mirMAP -0.174939960687697 0.000795488188834909 NA NA NA hsa-miR-590-3p KITLG 2.59289455139753 1.03200520972022e-21 -1.58421888595384 1.26958469493711e-05 MirTarget;PITA;miRanda -0.268795592510798 2.47160443003287e-05 NA NA NA hsa-miR-664a-3p KITLG 0.634721925861133 0.00520070178640421 -1.58421888595384 1.26958469493711e-05 mirMAP -0.588211133806444 1.00835052830132e-14 NA NA NA hsa-miR-7-1-3p KITLG 1.84950311431067 1.25300363397654e-13 -1.58421888595384 1.26958469493711e-05 mirMAP -0.239879555952607 0.000514707164304739 NA NA NA hsa-miR-590-3p LAMA2 2.59289455139753 1.03200520972022e-21 -2.83761923067566 3.05345389505506e-15 miRanda -0.567223566221854 9.61700716671867e-20 NA NA NA hsa-miR-125a-5p LAMA4 0.599529391575274 0.0102300147180307 -1.45595219375254 2.41526586222325e-06 miRanda -0.303220047597824 2.52964084512832e-06 NA NA NA hsa-miR-129-5p LAMA4 -0.524170159980738 0.222582956006346 -1.45595219375254 2.41526586222325e-06 MirTarget;miRanda -0.126506392446496 0.000401817629524722 NA NA NA hsa-miR-188-5p LAMA4 2.52825126596644 6.78099435999778e-14 -1.45595219375254 2.41526586222325e-06 miRNATAP -0.251561658477986 3.70275124549276e-08 NA NA NA hsa-miR-32-3p LAMA4 2.02436999565685 5.94091197945307e-09 -1.45595219375254 2.41526586222325e-06 MirTarget -0.364905358248472 1.13135628826242e-14 NA NA NA hsa-miR-429 LAMA4 4.48815175680773 2.44117492218206e-17 -1.45595219375254 2.41526586222325e-06 miRanda -0.30987627015593 7.77463421659655e-35 NA NA NA hsa-miR-590-3p LAMA4 2.59289455139753 1.03200520972022e-21 -1.45595219375254 2.41526586222325e-06 miRanda -0.423575282585973 1.12408650956982e-15 NA NA NA hsa-miR-590-5p LAMA4 3.18300989862077 2.06813568597893e-26 -1.45595219375254 2.41526586222325e-06 MirTarget;miRanda -0.400081606463855 1.60081982458864e-17 NA NA NA hsa-miR-93-3p LAMA4 2.85383869771942 5.64481766902125e-23 -1.45595219375254 2.41526586222325e-06 miRNAWalker2_validate -0.519585280066375 3.36684304275296e-29 NA NA NA hsa-miR-16-5p LAMB1 1.75824877145857 1.68592440033108e-16 -0.207410663395371 0.318155636576907 miRNAWalker2_validate -0.100767992497749 0.0274921578588146 NA NA NA hsa-miR-196b-5p LAMB2 1.71646270856386 4.37735885910369e-09 -1.33584397067882 2.99365639027516e-08 miRNAWalker2_validate -0.204406125848366 2.14274529560704e-07 NA NA NA hsa-miR-484 LAMB2 1.81844463411787 1.82951571230938e-15 -1.33584397067882 2.99365639027516e-08 miRNAWalker2_validate -0.432700661877785 3.04198926328285e-19 NA NA NA hsa-miR-218-5p LAMB3 -0.573801507392184 0.0551983860126703 1.04442552777857 0.0544713405047334 miRNAWalker2_validate;miRTarBase -0.319152266391447 0.000275496727879032 25337271;20163849;23320911;23159910;17998940 The aim of this study was to investigate whether polymorphisms in miR-218 LAMB3 pathway were associated with the risk and prognosis of esophageal squamous cell carcinoma ESCC;Polymorphisms involved in the miR 218 LAMB3 pathway and susceptibility of cervical cancer a case control study in Chinese women; MicroRNA-218 miR-218 can target laminin-5 beta3 LAMB3 but suppressed by HPV-16 E6 protein;However this association was not observed for the miR-218 binding site SNP rs2566 on LAMB3;Furthermore we focused on LAMB3 which has a miR-218 target site and gene expression studies and luciferase reporter assays showed that LAMB3 was directly regulated by miR-218;We also demonstrate that the epithelial cell-specific marker LAMB3 is a target of miR-218; We also show that LAMB3 expression is increased in the presence of the HPV-16 E6 oncogene and this effect is mediated through miR-218 worse prognosis;;;; esophageal cancer;cervical and endocervical cancer;cervical and endocervical cancer;head and neck cancer;cervical and endocervical cancer hsa-miR-107 LAMC1 1.30977326593435 1.30372468603965e-11 -0.820359806292778 9.59613230767155e-05 miRanda -0.233579030791372 6.43537798223682e-06 NA NA NA hsa-miR-126-5p LAMC1 0.895338176458417 2.33372756450713e-05 -0.820359806292778 9.59613230767155e-05 mirMAP -0.159911853705003 0.000923609611119757 NA NA NA hsa-miR-140-5p LAMC1 0.844753502512594 3.73722278438606e-05 -0.820359806292778 9.59613230767155e-05 MirTarget;PITA;miRanda;miRNATAP -0.187818567265583 0.000164349930813064 NA NA NA hsa-miR-15a-5p LAMC1 2.34669284378787 1.69544424500258e-23 -0.820359806292778 9.59613230767155e-05 MirTarget -0.279245991959823 5.28867371746872e-12 NA NA NA hsa-miR-15b-5p LAMC1 1.57112623124278 9.14247846750597e-13 -0.820359806292778 9.59613230767155e-05 MirTarget -0.267292362456671 2.53222057416082e-09 NA NA NA hsa-miR-16-5p LAMC1 1.75824877145857 1.68592440033108e-16 -0.820359806292778 9.59613230767155e-05 miRNAWalker2_validate;MirTarget -0.297384176391202 7.25329237041864e-11 NA NA NA hsa-miR-182-5p LAMC1 3.53923166221814 5.07781258121574e-21 -0.820359806292778 9.59613230767155e-05 miRNATAP -0.208617431877303 6.51660327570966e-17 NA NA NA hsa-miR-186-5p LAMC1 1.47445398888668 3.0781726595413e-15 -0.820359806292778 9.59613230767155e-05 mirMAP -0.348967724665269 2.74169617986783e-11 NA NA NA hsa-miR-188-5p LAMC1 2.52825126596644 6.78099435999778e-14 -0.820359806292778 9.59613230767155e-05 MirTarget -0.118785698529413 0.000144532288486678 NA NA NA hsa-miR-200b-3p LAMC1 3.78235093249346 3.18343003239465e-14 -0.820359806292778 9.59613230767155e-05 MirTarget;TargetScan -0.188439272819086 1.35940514922883e-23 NA NA NA hsa-miR-200c-3p LAMC1 3.50132673580082 2.42716349086937e-15 -0.820359806292778 9.59613230767155e-05 MirTarget;miRNATAP -0.189567753679175 8.99034744541273e-19 NA NA NA hsa-miR-29b-3p LAMC1 1.65828197923813 1.02676780888141e-09 -0.820359806292778 9.59613230767155e-05 MirTarget;miRNATAP -0.220232761632421 1.51273199871374e-09 NA NA NA hsa-miR-29c-3p LAMC1 -0.00968972577705429 0.97099586346872 -0.820359806292778 9.59613230767155e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.257554844225706 9.0369958667655e-12 NA NA NA hsa-miR-320a LAMC1 0.438165828017084 0.0390159073347133 -0.820359806292778 9.59613230767155e-05 miRanda -0.143719009142448 0.00309124251798942 NA NA NA hsa-miR-320b LAMC1 1.55692969039548 1.41071034251915e-08 -0.820359806292778 9.59613230767155e-05 miRanda -0.138452288194716 0.000157649490105486 NA NA NA hsa-miR-33a-3p LAMC1 1.72765312072219 1.51784443453521e-07 -0.820359806292778 9.59613230767155e-05 mirMAP -0.152727172481252 5.1457356703767e-06 NA NA NA hsa-miR-361-5p LAMC1 0.971859117235239 5.30236555707088e-09 -0.820359806292778 9.59613230767155e-05 miRanda -0.322314937131198 1.07220917823374e-07 NA NA NA hsa-miR-362-3p LAMC1 2.0756816987665 3.89026064579331e-12 -0.820359806292778 9.59613230767155e-05 miRanda -0.224673273037806 3.01231821033164e-11 NA NA NA hsa-miR-374a-5p LAMC1 0.484615721953736 0.0042981729815149 -0.820359806292778 9.59613230767155e-05 mirMAP -0.127813144072737 0.036890830950792 NA NA NA hsa-miR-429 LAMC1 4.48815175680773 2.44117492218206e-17 -0.820359806292778 9.59613230767155e-05 MirTarget;PITA;miRanda;miRNATAP -0.172219345654296 1.30033356324259e-22 NA NA NA hsa-miR-590-3p LAMC1 2.59289455139753 1.03200520972022e-21 -0.820359806292778 9.59613230767155e-05 PITA;miRanda;mirMAP -0.231819316952669 1.72376179745425e-10 NA NA NA hsa-miR-7-1-3p LAMC1 1.84950311431067 1.25300363397654e-13 -0.820359806292778 9.59613230767155e-05 mirMAP -0.227585122050958 7.55795416788432e-09 NA NA NA hsa-miR-92a-3p LAMC1 2.06460102658973 1.44784291084757e-19 -0.820359806292778 9.59613230767155e-05 miRNAWalker2_validate -0.25585756980471 1.61550207656933e-09 NA NA NA hsa-miR-942-5p LAMC1 2.35195531153712 5.45059325728841e-16 -0.820359806292778 9.59613230767155e-05 MirTarget -0.199082047259579 2.90254597627543e-09 NA NA NA hsa-miR-96-5p LAMC1 4.89433085814374 1.92000659886961e-31 -0.820359806292778 9.59613230767155e-05 MirTarget;TargetScan;miRNATAP -0.194526518099266 2.67470382634379e-18 NA NA NA hsa-miR-98-5p LAMC1 1.11154309866014 1.24143909012085e-08 -0.820359806292778 9.59613230767155e-05 miRNAWalker2_validate -0.287258937188904 2.27097321682406e-08 NA NA NA hsa-miR-125a-5p LAMC2 0.599529391575274 0.0102300147180307 2.24370532975042 5.48773878317138e-05 MirTarget;miRanda -0.301052127742519 0.00995434131377062 NA NA NA hsa-miR-320a LAMC2 0.438165828017084 0.0390159073347133 2.24370532975042 5.48773878317138e-05 miRanda -0.326461942995075 0.0113524781870599 NA NA NA hsa-miR-542-3p LAMC2 1.18832665895751 1.98700670691565e-07 2.24370532975042 5.48773878317138e-05 miRanda -0.261960091603407 0.0265231453463287 NA NA NA hsa-miR-130a-3p LAMC3 2.02021855058359 1.26427102520415e-11 -2.92491806352548 5.56179940172618e-14 mirMAP -0.34569235276552 3.70493167415657e-08 NA NA NA hsa-miR-130b-3p LAMC3 3.5350292994509 1.73934183852569e-27 -2.92491806352548 5.56179940172618e-14 mirMAP -0.35287057640399 1.22863458022381e-10 NA NA NA hsa-miR-185-3p LAMC3 2.3922478518806 1.3373426768452e-14 -2.92491806352548 5.56179940172618e-14 mirMAP -0.211844901305224 0.000458123520333771 NA NA NA hsa-miR-192-5p LAMC3 2.69002528723195 1.22990188194432e-16 -2.92491806352548 5.56179940172618e-14 mirMAP -0.193335624455308 0.000772195863711937 NA NA NA hsa-miR-2355-5p LAMC3 1.32510310704724 8.25139516692683e-07 -2.92491806352548 5.56179940172618e-14 mirMAP -0.312069911618652 1.15000953132186e-05 NA NA NA hsa-miR-301a-3p LAMC3 2.81024345929638 2.29784847962242e-17 -2.92491806352548 5.56179940172618e-14 mirMAP -0.287092393464821 1.15708222902673e-06 NA NA NA hsa-miR-324-3p LAMC3 2.08739139768981 3.11885987067952e-13 -2.92491806352548 5.56179940172618e-14 mirMAP -0.272884717327376 3.2555735302809e-05 NA NA NA hsa-miR-330-5p LAMC3 1.15100069700871 4.85551805046014e-07 -2.92491806352548 5.56179940172618e-14 MirTarget;miRanda -0.217463020367138 0.0100115843333794 NA NA NA hsa-miR-335-5p LAMC3 1.77247705492746 2.22457658872091e-06 -2.92491806352548 5.56179940172618e-14 mirMAP -0.121313222611885 0.0180886320641665 NA NA NA hsa-miR-3614-5p LAMC3 2.17736331059655 2.19144831318484e-08 -2.92491806352548 5.56179940172618e-14 mirMAP -0.169548519276859 0.000835293174294598 NA NA NA hsa-miR-425-5p LAMC3 3.07071373939774 4.02947460586085e-25 -2.92491806352548 5.56179940172618e-14 mirMAP -0.331892033423074 5.33720067099948e-08 NA NA NA hsa-miR-452-5p LAMC3 1.37180058737183 0.00171494843537772 -2.92491806352548 5.56179940172618e-14 mirMAP -0.182023381957247 3.39832965459897e-05 NA NA NA hsa-miR-505-5p LAMC3 1.89243395287645 9.82003586561819e-12 -2.92491806352548 5.56179940172618e-14 mirMAP -0.220162531375535 0.00127205908147736 NA NA NA hsa-let-7f-1-3p LPAR1 1.55054488387679 7.31326775537952e-11 -1.92450185312715 3.73367853480122e-09 mirMAP -0.146299343149251 0.032704069894609 NA NA NA hsa-miR-1287-5p LPAR1 0.712189050180771 0.00496124953411707 -1.92450185312715 3.73367853480122e-09 MirTarget -0.271287322561448 1.76093518018085e-05 NA NA NA hsa-miR-16-2-3p LPAR1 2.31623086727196 4.29838149388188e-20 -1.92450185312715 3.73367853480122e-09 MirTarget;mirMAP -0.357988024968201 2.61094855846002e-09 NA NA NA hsa-miR-188-5p LPAR1 2.52825126596644 6.78099435999778e-14 -1.92450185312715 3.73367853480122e-09 MirTarget -0.365364427958334 2.35541669467778e-14 NA NA NA hsa-miR-200b-3p LPAR1 3.78235093249346 3.18343003239465e-14 -1.92450185312715 3.73367853480122e-09 MirTarget;TargetScan -0.188052756743685 8.75083728372006e-10 NA NA NA hsa-miR-200c-3p LPAR1 3.50132673580082 2.42716349086937e-15 -1.92450185312715 3.73367853480122e-09 miRNAWalker2_validate;MirTarget;miRNATAP -0.184541391970303 1.02192042157423e-07 NA NA NA hsa-miR-20a-3p LPAR1 2.92621109947706 2.49504904635375e-17 -1.92450185312715 3.73367853480122e-09 MirTarget -0.335586011313492 6.04688953604777e-14 NA NA NA hsa-miR-32-3p LPAR1 2.02436999565685 5.94091197945307e-09 -1.92450185312715 3.73367853480122e-09 mirMAP -0.295385188819552 7.4102390613455e-09 NA NA NA hsa-miR-324-5p LPAR1 2.95683728155095 1.32960514360912e-20 -1.92450185312715 3.73367853480122e-09 miRanda -0.428874894880674 1.48728148142287e-20 NA NA NA hsa-miR-335-3p LPAR1 3.08791651139852 5.31309869723517e-12 -1.92450185312715 3.73367853480122e-09 mirMAP -0.153530346268326 9.78148552681204e-06 NA NA NA hsa-miR-339-5p LPAR1 2.68710938429893 3.03134080808154e-16 -1.92450185312715 3.73367853480122e-09 miRanda -0.295707224576425 1.67488518155583e-10 NA NA NA hsa-miR-342-3p LPAR1 1.49115144672245 1.43879249744621e-07 -1.92450185312715 3.73367853480122e-09 miRanda -0.187662418812228 0.00080231935737044 NA NA NA hsa-miR-361-5p LPAR1 0.971859117235239 5.30236555707088e-09 -1.92450185312715 3.73367853480122e-09 miRanda -0.586397778608277 6.12208281943422e-10 NA NA NA hsa-miR-374a-5p LPAR1 0.484615721953736 0.0042981729815149 -1.92450185312715 3.73367853480122e-09 MirTarget -0.201566462393544 0.0362609549400328 NA NA NA hsa-miR-421 LPAR1 1.17791565395543 6.78526676976629e-06 -1.92450185312715 3.73367853480122e-09 miRanda -0.392494804767812 6.10158227634918e-11 NA NA NA hsa-miR-429 LPAR1 4.48815175680773 2.44117492218206e-17 -1.92450185312715 3.73367853480122e-09 MirTarget;miRanda;miRNATAP -0.194448309450667 8.30222624485601e-12 NA NA NA hsa-miR-501-5p LPAR1 1.93654809410041 1.3779381780759e-10 -1.92450185312715 3.73367853480122e-09 MirTarget;miRNATAP -0.429568403736502 1.35417507499108e-16 NA NA NA hsa-miR-576-5p LPAR1 2.20467023993664 3.4053475193793e-19 -1.92450185312715 3.73367853480122e-09 mirMAP -0.380653273426869 6.8084471849334e-10 NA NA NA hsa-miR-671-5p LPAR1 2.97733652243246 1.21148452344738e-23 -1.92450185312715 3.73367853480122e-09 MirTarget -0.289083968512443 6.84956233792744e-08 NA NA NA hsa-miR-7-1-3p LPAR1 1.84950311431067 1.25300363397654e-13 -1.92450185312715 3.73367853480122e-09 MirTarget -0.30444336093743 1.00667069291427e-06 NA NA NA hsa-miR-874-3p LPAR1 1.95617235160298 2.0152613104032e-12 -1.92450185312715 3.73367853480122e-09 MirTarget -0.127100477892148 0.0246391681859892 NA NA NA hsa-miR-143-3p LPAR2 -2.5789192793377 1.55518999614836e-14 2.09195803325664 2.37447910992728e-18 miRNATAP -0.279346101272712 9.91112750776813e-17 NA NA NA hsa-miR-101-3p MAP2K1 0.522819989585461 0.00375627731618038 0.329146605656592 0.0110879553061078 miRNAWalker2_validate -0.179174585612232 2.32589570104786e-07 NA NA NA hsa-miR-30c-5p MAP2K1 0.778774633108 0.000285599212429136 0.329146605656592 0.0110879553061078 miRNAWalker2_validate -0.1435696131991 6.86626187272449e-07 NA NA NA hsa-miR-140-3p MAPK1 0.0608890720479334 0.727716871248724 -0.300413846088826 0.0202503240217449 PITA;miRNATAP -0.126850675206772 0.000457308593536618 NA NA NA hsa-miR-30c-5p MAPK1 0.778774633108 0.000285599212429136 -0.300413846088826 0.0202503240217449 mirMAP -0.161696427374548 1.83237959021178e-08 NA NA NA hsa-miR-30e-5p MAPK1 1.23904909539663 1.35561917122157e-09 -0.300413846088826 0.0202503240217449 mirMAP -0.123981973754552 3.68994437193015e-05 NA NA NA hsa-miR-34a-5p MAPK1 1.9016323452565 1.43092834643601e-14 -0.300413846088826 0.0202503240217449 mirMAP -0.113934200811126 2.89029232507908e-06 NA NA NA hsa-let-7g-3p MCL1 3.26398061402445 3.96263126107645e-25 -0.966384598042312 6.2852193244413e-09 MirTarget;miRNATAP -0.115810411362269 3.39117883522902e-06 NA NA NA hsa-miR-101-3p MCL1 0.522819989585461 0.00375627731618038 -0.966384598042312 6.2852193244413e-09 miRNAWalker2_validate;miRTarBase -0.154167833785504 0.00074378867351686 21993632;19155302;26036638 MiR 101 and Mcl 1 in non small cell lung cancer: expression profile and clinical significance; The aim of this study was to investigate the expression profile of miR-101 and its target gene Mcl-1 in NSCLC and to assess their clinical significance; QRT-PCR was used in the detection of miR-101 and Mcl-1 mRNA expression both in NSCLC tissue and in adjacent normal lung tissue; Down-regulation of miR-101 was associated with overexpression of Mcl-1 mRNA in NSCLC tissue when compared with corresponding normal tissue with a negative correlation r = -0.724 P < 0.01; A comparison of survival curves of low versus high expressers of miR-101 and Mcl-1 revealed a highly significant difference in NSCLC P < 0.05 which suggests that reduced expression of miR-101 versus overexpression of Mcl-1 is associated with a poorer prognosis; Our results suggest that down-regulation of miR-101 may result in enhanced expression of Mcl-1 in NSCLC which consequently favored tumor progression; MiR-101 and Mcl-1 may play important roles as biomarkers for prognosis and therapeutic targets in NSCLC;Moreover silencing of Mcl-1 phenocopied the effect of miR-101 and forced expression of Mcl-1 could reverse the proapoptotic effect of miR-101; These results indicate that miR-101 may exert its proapoptotic function via targeting Mcl-1;The aim of our study was to investigate the functional role of both miR-101 and MCL-1 in the sensitivity of human triple-negative breast cancer TNBC to paclitaxel; Luciferase assay results confirmed MCL-1 as a direct target gene of miR-101; MiR-101 inhibited MCL-1 expression in TNBC cells and transplanted tumors; There was a negative correlation between the level of expression of miR-101 and MCL-1 in TNBC tissues; Furthermore miR-101 increased paclitaxel sensitivity by inhibiting MCL-1 expression worse prognosis;poor survival;progression;; lung squamous cell cancer;liver cancer;breast cancer hsa-miR-106b-5p MCL1 2.46782146831112 1.36171495805632e-23 -0.966384598042312 6.2852193244413e-09 MirTarget;miRNATAP -0.175969517504363 1.46516427491805e-08 NA NA NA hsa-miR-125a-5p MCL1 0.599529391575274 0.0102300147180307 -0.966384598042312 6.2852193244413e-09 MirTarget;PITA;miRanda -0.179850478189693 2.32572836009865e-07 NA NA NA hsa-miR-148b-5p MCL1 2.18024067300781 2.84770452413262e-14 -0.966384598042312 6.2852193244413e-09 miRNAWalker2_validate -0.125866449821125 1.53117330549739e-05 NA NA NA hsa-miR-151a-3p MCL1 1.24018761527407 1.08839919675408e-07 -0.966384598042312 6.2852193244413e-09 miRNAWalker2_validate -0.198519929966059 6.3961593224112e-09 NA NA NA hsa-miR-15a-5p MCL1 2.34669284378787 1.69544424500258e-23 -0.966384598042312 6.2852193244413e-09 miRNAWalker2_validate -0.107808676234929 0.00110378696128458 NA NA NA hsa-miR-17-5p MCL1 3.2710598467455 9.93128340539455e-27 -0.966384598042312 6.2852193244413e-09 MirTarget;TargetScan;miRNATAP -0.108351617760068 1.42433347252796e-05 NA NA NA hsa-miR-186-5p MCL1 1.47445398888668 3.0781726595413e-15 -0.966384598042312 6.2852193244413e-09 miRNAWalker2_validate;mirMAP -0.133392046569594 0.00178902572097603 NA NA NA hsa-miR-20a-5p MCL1 3.15577933619191 4.19753346442454e-25 -0.966384598042312 6.2852193244413e-09 MirTarget;miRNATAP -0.113265036863355 6.45027870943099e-06 23594563 Subsequent investigations revealed that miR-20a directly targeted myeloid cell leukemia sequence 1 Mcl-1 and reduced the endogenous protein level of Mcl-1 in HCC cells liver cancer hsa-miR-30d-5p MCL1 0.675423997639582 0.00270618816039773 -0.966384598042312 6.2852193244413e-09 miRNAWalker2_validate -0.196335685987109 4.80731179408169e-08 NA NA NA hsa-miR-320a MCL1 0.438165828017084 0.0390159073347133 -0.966384598042312 6.2852193244413e-09 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.153148453172002 7.38962353071285e-05 26753959 Down regulation of miR 320 associated with cancer progression and cell apoptosis via targeting Mcl 1 in cervical cancer; MiR-320 has been reported to be down-regulated in various types of cancer and bioinformatics prediction indicated that it may regulate the expression of Mcl-1; The aim of this study is to investigate the role of miR-320 and its target gene Mcl-1 in cervical cancer progression and to assess their clinical significance; miR-320 and Mcl-1 expressions in human cervical cancer tissues were investigated by qRT-PCR in situ hybridization and immunohistochemical staining respectively; MiR-320 expression is significantly down-regulated versus Mcl-1 expression is up-regulated in cervical cancer tissues compared with normal controls with a negative correlation between them; Luciferase assay showed that miR-320 negatively regulates Mcl-1 expression; In addition miR-320 induces apoptosis via down-regulation of Mcl-1 and activation of caspase-3 but inhibits cell proliferation migration invasion and tumorigenesis in cervical cancer cells; Our studies show that miR-320 expression is decreased in cervical cancer and its expression is negatively correlated with Mcl-1 expression in cervical cancer; In addition miR-320 inhibits cervical cancer progression by down-regulation of Mcl-1 progression;tumorigenesis cervical and endocervical cancer hsa-miR-335-3p MCL1 3.08791651139852 5.31309869723517e-12 -0.966384598042312 6.2852193244413e-09 mirMAP -0.104489944006683 2.24625518502697e-09 NA NA NA hsa-miR-361-5p MCL1 0.971859117235239 5.30236555707088e-09 -0.966384598042312 6.2852193244413e-09 miRanda -0.254409362204897 1.52555889152521e-07 NA NA NA hsa-miR-93-5p MCL1 3.03961860136032 1.11672209617395e-24 -0.966384598042312 6.2852193244413e-09 MirTarget;miRNATAP -0.182893495021059 5.94058378435324e-13 NA NA NA hsa-miR-940 MCL1 3.21011374578759 2.7923171128495e-14 -0.966384598042312 6.2852193244413e-09 PITA;miRNATAP -0.133864697880394 2.41178789209135e-11 NA NA NA hsa-miR-139-5p MET -1.52606598644743 1.20474151350665e-08 0.837921883229614 0.00151106668605525 miRanda -0.150181339310228 0.0014579314310779 NA NA NA hsa-miR-23b-3p MET -0.251132426825047 0.150200321210792 0.837921883229614 0.00151106668605525 miRNAWalker2_validate;miRTarBase -0.255547305484638 0.000600589642295463 19490101 MicroRNA 23b mediates urokinase and c met downmodulation and a decreased migration of human hepatocellular carcinoma cells; In the present study to understand whether the expression of these genes might be coregulated by specific microRNAs miRs in human cells we predicted that Homo sapiens microRNA-23b could recognize two sites in the 3'-UTR of uPA and four sites in the c-met 3'-UTR by the algorithm pictar; The evidence obtained shows that overexpression of miR-23b leads to uPA and c-met downregulation and to decreased migration and proliferation abilities of HCC cells liver cancer hsa-miR-30e-3p MET -0.215663037684509 0.235375122783546 0.837921883229614 0.00151106668605525 mirMAP -0.185298092546442 0.00970912795928673 NA NA NA hsa-miR-664a-3p MET 0.634721925861133 0.00520070178640421 0.837921883229614 0.00151106668605525 mirMAP -0.111443032425202 0.0498846937310092 NA NA NA hsa-miR-127-3p MTCP1 -0.6279281852298 0.0400829468424132 0.841327326100209 4.96162205751566e-05 PITA;miRanda -0.161985997101561 7.44823547107407e-07 NA NA NA hsa-let-7f-5p MYC 0.495648727272215 0.00355972741198794 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.302610362502413 0.00593577090066522 NA NA NA hsa-let-7g-5p MYC 1.20061455355116 1.50237505511483e-12 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.647634835001101 8.67569135821405e-10 NA NA NA hsa-miR-320a MYC 0.438165828017084 0.0390159073347133 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.270203083250914 0.00203008366284758 25736597 Furthermore progesterone P4 promoted the expression of miR-320a by repressing c-Myc expression while estrogen E2 exerted the opposite effect breast cancer hsa-miR-320b MYC 1.55692969039548 1.41071034251915e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.211227042104883 0.00142753396089349 26487644 miR 320b suppresses cell proliferation by targeting c Myc in human colorectal cancer cells; Overexpression of miR-320b in CRC cells was statistically correlated with a decrease of cell growth in vitro and in vivo while c-MYC was identified as a target gene of miR-320b in CRC; Furthermore it was found that up-regulation of c-Myc can attenuate the effects induced by miR-320b; Our identification of c-MYC as a target gene of miR-320b provides new insights into the pathophysiology of CRC proliferation and identifies miR-320b as a novel therapeutic target for the treatment of CRC colorectal cancer hsa-miR-335-5p MYC 1.77247705492746 2.22457658872091e-06 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.15527675337735 0.00141118517916367 NA NA NA hsa-miR-34a-5p MYC 1.9016323452565 1.43092834643601e-14 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.359767953473847 5.62932761832786e-07 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-423-5p MYC 0.963563145758616 9.86109015204915e-07 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.592117097378242 1.10389937335588e-10 NA NA NA hsa-miR-429 MYC 4.48815175680773 2.44117492218206e-17 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.269400502460394 6.09134482841112e-17 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-744-5p MYC 1.48254348878737 3.23019501613577e-09 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.254793177391621 0.000439915184612437 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-miR-98-5p MYC 1.11154309866014 1.24143909012085e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.602921793997467 5.7325871539819e-11 NA NA NA hsa-miR-450b-5p NFKB1 1.69244418548325 1.68064054148881e-10 -0.64818153460532 4.948433163113e-05 MirTarget;PITA -0.124463449584444 1.35101416784659e-05 NA NA NA hsa-miR-92a-3p NFKB1 2.06460102658973 1.44784291084757e-19 -0.64818153460532 4.948433163113e-05 miRNAWalker2_validate -0.146602812476967 6.42472618908431e-06 NA NA NA hsa-let-7a-5p NGF 0.618599506841644 2.76973453058748e-05 -2.40747957908931 8.29529053936123e-07 MirTarget;TargetScan -0.725600120025055 8.99703032904097e-06 NA NA NA hsa-let-7b-5p NGF 0.604314269683977 0.00140009936153214 -2.40747957908931 8.29529053936123e-07 MirTarget -0.445902124296935 0.000457128474125706 NA NA NA hsa-let-7d-5p NGF 1.33236798905207 1.1741085658466e-13 -2.40747957908931 8.29529053936123e-07 MirTarget -0.678554815907685 1.63174808684775e-07 NA NA NA hsa-let-7e-5p NGF 0.860104282510173 6.04758298373779e-05 -2.40747957908931 8.29529053936123e-07 MirTarget -0.426192872238101 0.000127971345995895 NA NA NA hsa-let-7f-5p NGF 0.495648727272215 0.00355972741198794 -2.40747957908931 8.29529053936123e-07 MirTarget -0.599266844830758 2.3727191387735e-05 NA NA NA hsa-let-7g-5p NGF 1.20061455355116 1.50237505511483e-12 -2.40747957908931 8.29529053936123e-07 MirTarget -1.06245785714021 3.64026543085871e-15 NA NA NA hsa-miR-125a-3p NGF 1.24490295132072 5.26925231010328e-06 -2.40747957908931 8.29529053936123e-07 miRanda -0.250797549188537 0.00395961103629666 NA NA NA hsa-miR-320a NGF 0.438165828017084 0.0390159073347133 -2.40747957908931 8.29529053936123e-07 miRanda -0.444107483987704 8.7035614427142e-05 NA NA NA hsa-miR-320b NGF 1.55692969039548 1.41071034251915e-08 -2.40747957908931 8.29529053936123e-07 miRanda -0.423772071383533 6.50389232533904e-07 NA NA NA hsa-miR-423-5p NGF 0.963563145758616 9.86109015204915e-07 -2.40747957908931 8.29529053936123e-07 MirTarget;miRNATAP -0.803354433746443 1.32594577043773e-11 NA NA NA hsa-miR-429 NGF 4.48815175680773 2.44117492218206e-17 -2.40747957908931 8.29529053936123e-07 miRanda -0.382290239888962 2.67088438561565e-20 NA NA NA hsa-miR-98-5p NGF 1.11154309866014 1.24143909012085e-08 -2.40747957908931 8.29529053936123e-07 MirTarget -0.660953034981452 3.88812196488546e-08 NA NA NA hsa-miR-10a-5p NGFR 1.15016989191194 0.00372037233992369 -2.71562668756498 2.85979409356053e-06 mirMAP -0.349830558159561 7.34289826499961e-07 NA NA NA hsa-miR-148b-5p NGFR 2.18024067300781 2.84770452413262e-14 -2.71562668756498 2.85979409356053e-06 mirMAP -0.704312299780778 1.27912758313244e-12 NA NA NA hsa-miR-15b-3p NGFR 2.33847028227712 4.29662877950836e-19 -2.71562668756498 2.85979409356053e-06 mirMAP -0.744011627633713 2.10872087483696e-13 NA NA NA hsa-miR-185-3p NGFR 2.3922478518806 1.3373426768452e-14 -2.71562668756498 2.85979409356053e-06 miRNATAP -0.562726263803502 9.25850438395162e-11 NA NA NA hsa-miR-2110 NGFR 1.16625590651194 6.4784195289885e-05 -2.71562668756498 2.85979409356053e-06 mirMAP -0.550462813515311 8.4806966972975e-08 NA NA NA hsa-miR-30b-3p NGFR 0.834142820354026 0.000972582820878813 -2.71562668756498 2.85979409356053e-06 mirMAP -0.509892987476281 5.30030705709418e-06 NA NA NA hsa-miR-324-5p NGFR 2.95683728155095 1.32960514360912e-20 -2.71562668756498 2.85979409356053e-06 miRanda -0.625160382556244 4.47533262755334e-14 NA NA NA hsa-miR-326 NGFR 0.715313016136042 0.0610265683213359 -2.71562668756498 2.85979409356053e-06 miRanda;mirMAP -0.206756853583392 0.00563433618434518 NA NA NA hsa-miR-330-5p NGFR 1.15100069700871 4.85551805046014e-07 -2.71562668756498 2.85979409356053e-06 miRanda;mirMAP;miRNATAP -0.426646939175543 0.000526043332395512 NA NA NA hsa-miR-335-5p NGFR 1.77247705492746 2.22457658872091e-06 -2.71562668756498 2.85979409356053e-06 miRNAWalker2_validate -0.291559067143429 9.30146106620593e-05 NA NA NA hsa-miR-342-5p NGFR 1.74634624752902 3.89286511372155e-11 -2.71562668756498 2.85979409356053e-06 mirMAP -0.386119166659559 0.000239223466663646 NA NA NA hsa-miR-34a-5p NGFR 1.9016323452565 1.43092834643601e-14 -2.71562668756498 2.85979409356053e-06 mirMAP -0.651447322603427 3.13859594639451e-09 NA NA NA hsa-miR-3614-5p NGFR 2.17736331059655 2.19144831318484e-08 -2.71562668756498 2.85979409356053e-06 mirMAP -0.181196308315712 0.0149100467792175 NA NA NA hsa-miR-429 NGFR 4.48815175680773 2.44117492218206e-17 -2.71562668756498 2.85979409356053e-06 miRNATAP -0.511940678313265 3.59791729760487e-26 NA NA NA hsa-miR-429 NOS3 4.48815175680773 2.44117492218206e-17 -0.878800989819862 0.000752437995889313 miRanda -0.132117856078783 4.86582987596031e-09 NA NA NA hsa-let-7d-5p NR4A1 1.33236798905207 1.1741085658466e-13 -4.37235366597705 9.50064560522938e-27 miRNAWalker2_validate -0.607753554509923 9.77690185266994e-08 NA NA NA hsa-miR-125a-3p NR4A1 1.24490295132072 5.26925231010328e-06 -4.37235366597705 9.50064560522938e-27 miRanda -0.253206793926018 0.00093511286530804 26782438 There were no significant correlations between miR-125 expression and other clinicopathological features including tumor size histological grade hormone receptor status Her-2 status and lymph node metastasis metastasis;tumor size breast cancer hsa-miR-196a-5p NR4A1 1.52993069622497 0.00397268663639603 -4.37235366597705 9.50064560522938e-27 miRNAWalker2_validate -0.15198162396951 0.000112144770862419 NA NA NA hsa-miR-324-5p NR4A1 2.95683728155095 1.32960514360912e-20 -4.37235366597705 9.50064560522938e-27 miRanda -0.416525208476142 1.71884245649331e-11 NA NA NA hsa-miR-335-5p NR4A1 1.77247705492746 2.22457658872091e-06 -4.37235366597705 9.50064560522938e-27 miRNAWalker2_validate -0.154428679787295 0.00549636446023487 NA NA NA hsa-miR-361-5p NR4A1 0.971859117235239 5.30236555707088e-09 -4.37235366597705 9.50064560522938e-27 miRanda -0.737728322507883 3.01478134123423e-09 NA NA NA hsa-miR-362-3p NR4A1 2.0756816987665 3.89026064579331e-12 -4.37235366597705 9.50064560522938e-27 miRanda -0.195713614861691 0.00592846562436674 NA NA NA hsa-miR-542-3p NR4A1 1.18832665895751 1.98700670691565e-07 -4.37235366597705 9.50064560522938e-27 PITA;miRanda -0.249806826064396 0.00638202164861832 NA NA NA hsa-miR-93-5p NR4A1 3.03961860136032 1.11672209617395e-24 -4.37235366597705 9.50064560522938e-27 miRNAWalker2_validate -0.442106606247051 1.73647020314414e-11 NA NA NA hsa-miR-29c-3p NRAS -0.00968972577705429 0.97099586346872 0.638705716882092 3.80929355945655e-05 miRNATAP -0.151007715222895 7.79757166468808e-08 NA NA NA hsa-miR-664a-3p NRAS 0.634721925861133 0.00520070178640421 0.638705716882092 3.80929355945655e-05 MirTarget -0.156789929856636 2.10592676639858e-06 NA NA NA hsa-miR-142-3p NTF3 2.75247908790621 1.45636065474764e-12 -3.30762378554694 2.95059143066034e-13 miRanda -0.289559750333271 2.18084109404098e-07 NA NA NA hsa-miR-21-5p NTF3 2.73773305747971 1.38864982139576e-43 -3.30762378554694 2.95059143066034e-13 miRTarBase;miRNATAP -0.718377718022019 1.14136463226806e-12 NA NA NA hsa-miR-221-3p NTF3 0.451556679024397 0.0909808299917811 -3.30762378554694 2.95059143066034e-13 miRNATAP -0.464707209676713 2.88362012880969e-08 NA NA NA hsa-miR-222-3p NTF3 0.851783756239071 0.00266783568486918 -3.30762378554694 2.95059143066034e-13 miRNATAP -0.529220907365481 1.05244018417693e-11 NA NA NA hsa-miR-320b NTF3 1.55692969039548 1.41071034251915e-08 -3.30762378554694 2.95059143066034e-13 miRanda -0.166442754558627 0.0407619924430038 NA NA NA hsa-miR-421 NTF3 1.17791565395543 6.78526676976629e-06 -3.30762378554694 2.95059143066034e-13 miRanda -0.227952411175781 0.00806835785015479 NA NA NA hsa-miR-590-3p NTF3 2.59289455139753 1.03200520972022e-21 -3.30762378554694 2.95059143066034e-13 miRanda -0.340175587260053 2.82489458563848e-05 NA NA NA hsa-miR-590-5p NTF3 3.18300989862077 2.06813568597893e-26 -3.30762378554694 2.95059143066034e-13 PITA;miRanda;miRNATAP -0.33125375143849 4.71667151153976e-06 NA NA NA hsa-miR-107 NTRK2 1.30977326593435 1.30372468603965e-11 -3.4444884279512 9.02401971614574e-08 PITA;miRanda -1.10328807131129 2.46161403963682e-12 NA NA NA hsa-miR-125a-3p NTRK2 1.24490295132072 5.26925231010328e-06 -3.4444884279512 9.02401971614574e-08 miRanda -0.376033016875365 0.00107171920041796 NA NA NA hsa-miR-126-5p NTRK2 0.895338176458417 2.33372756450713e-05 -3.4444884279512 9.02401971614574e-08 mirMAP -0.461947070179665 0.00199468881131289 NA NA NA hsa-miR-130b-3p NTRK2 3.5350292994509 1.73934183852569e-27 -3.4444884279512 9.02401971614574e-08 mirMAP -0.655009379767134 1.53407544109055e-13 NA NA NA hsa-miR-130b-5p NTRK2 2.9963110846538 1.98883029416455e-18 -3.4444884279512 9.02401971614574e-08 mirMAP -0.664721546737953 6.35250159481337e-14 NA NA NA hsa-miR-151a-5p NTRK2 2.32422038747303 2.66226949101065e-18 -3.4444884279512 9.02401971614574e-08 miRNATAP -0.871234808600496 3.71142225770198e-15 NA NA NA hsa-miR-15b-3p NTRK2 2.33847028227712 4.29662877950836e-19 -3.4444884279512 9.02401971614574e-08 mirMAP -0.78865263855268 3.47760542097815e-12 NA NA NA hsa-miR-17-3p NTRK2 2.2704817679209 1.1667437320211e-22 -3.4444884279512 9.02401971614574e-08 miRNATAP -0.986404899520973 5.60866733893115e-15 NA NA NA hsa-miR-181a-5p NTRK2 2.29556023480783 1.8138457900616e-21 -3.4444884279512 9.02401971614574e-08 mirMAP -0.641712336343684 2.29468859355526e-07 NA NA NA hsa-miR-181b-5p NTRK2 2.49307679431293 3.92829250217627e-20 -3.4444884279512 9.02401971614574e-08 mirMAP -0.623644911740744 1.48869667340713e-08 NA NA NA hsa-miR-181c-5p NTRK2 1.58587920618301 1.57506918816933e-10 -3.4444884279512 9.02401971614574e-08 mirMAP -0.487056006099362 9.7916777419054e-05 NA NA NA hsa-miR-182-5p NTRK2 3.53923166221814 5.07781258121574e-21 -3.4444884279512 9.02401971614574e-08 mirMAP -0.542854638305866 3.89545557204651e-12 NA NA NA hsa-miR-185-5p NTRK2 2.34016206907488 1.17481626642022e-26 -3.4444884279512 9.02401971614574e-08 mirMAP -0.908221744534185 1.04154350912728e-11 NA NA NA hsa-miR-186-5p NTRK2 1.47445398888668 3.0781726595413e-15 -3.4444884279512 9.02401971614574e-08 mirMAP -1.08361132863423 2.28591646607224e-11 NA NA NA hsa-miR-200c-3p NTRK2 3.50132673580082 2.42716349086937e-15 -3.4444884279512 9.02401971614574e-08 miRNAWalker2_validate;miRTarBase -0.558218294130396 5.1648144515451e-17 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-20a-3p NTRK2 2.92621109947706 2.49504904635375e-17 -3.4444884279512 9.02401971614574e-08 mirMAP -0.638958030834559 4.2820526373737e-13 NA NA NA hsa-miR-21-5p NTRK2 2.73773305747971 1.38864982139576e-43 -3.4444884279512 9.02401971614574e-08 mirMAP -0.426222870969759 0.00330777931884449 NA NA NA hsa-miR-22-3p NTRK2 1.21545661147757 1.61670170137775e-13 -3.4444884279512 9.02401971614574e-08 miRNATAP -0.792113978350115 2.65895272261461e-05 27662840 NTRK2 is an oncogene and associated with microRNA 22 regulation in human gastric cancer cell lines; The upstream regulator of NTRK2 microRNA-22 miR-22 was evaluated by dual-luciferase assay; In miR-22-upregulated MKN-28 and SNU-719 cells NTRK2 was further overexpressed to evaluate functional interaction between miR-22 and NTRK2 in GC; MiR-22 was verified to be an inverse upstream regulator of NTRK2; NTRK2 is an oncogene and reversely associated with miR-22 in regulating in vitro cancer development in GC gastric cancer hsa-miR-224-3p NTRK2 1.87536386559317 6.15140969394846e-05 -3.4444884279512 9.02401971614574e-08 mirMAP -0.251953296536257 0.000320280319633908 NA NA NA hsa-miR-26b-5p NTRK2 0.885393662798425 3.2116297961629e-06 -3.4444884279512 9.02401971614574e-08 mirMAP -0.918548097668709 2.31015434348151e-08 NA NA NA hsa-miR-29a-5p NTRK2 1.46749674755271 3.34605004270294e-07 -3.4444884279512 9.02401971614574e-08 mirMAP -0.413787908321922 0.000315700519378732 NA NA NA hsa-miR-301a-3p NTRK2 2.81024345929638 2.29784847962242e-17 -3.4444884279512 9.02401971614574e-08 mirMAP -0.744969523901533 2.39919848998948e-15 NA NA NA hsa-miR-3065-5p NTRK2 2.74629919868982 1.86846589298284e-08 -3.4444884279512 9.02401971614574e-08 mirMAP -0.286324800403609 0.00023527787223171 NA NA NA hsa-miR-30b-5p NTRK2 0.800822374912712 0.000133601914525413 -3.4444884279512 9.02401971614574e-08 mirMAP -0.546689649319654 0.00029099120653431 NA NA NA hsa-miR-30c-5p NTRK2 0.778774633108 0.000285599212429136 -3.4444884279512 9.02401971614574e-08 mirMAP -0.689336493365858 2.58508921415882e-06 NA NA NA hsa-miR-30d-3p NTRK2 0.977747550180601 4.3048212205381e-05 -3.4444884279512 9.02401971614574e-08 mirMAP -0.665503813522632 3.72555641617031e-07 NA NA NA hsa-miR-30d-5p NTRK2 0.675423997639582 0.00270618816039773 -3.4444884279512 9.02401971614574e-08 mirMAP -0.687091926033502 8.8466750322348e-07 NA NA NA hsa-miR-30e-3p NTRK2 -0.215663037684509 0.235375122783546 -3.4444884279512 9.02401971614574e-08 mirMAP -0.560142851781332 0.00151121456503575 NA NA NA hsa-miR-30e-5p NTRK2 1.23904909539663 1.35561917122157e-09 -3.4444884279512 9.02401971614574e-08 mirMAP -0.997379711717577 3.00290798335836e-11 NA NA NA hsa-miR-32-3p NTRK2 2.02436999565685 5.94091197945307e-09 -3.4444884279512 9.02401971614574e-08 mirMAP -0.59869849424457 2.50361692819518e-09 NA NA NA hsa-miR-32-5p NTRK2 2.34056473219422 6.24134585974322e-20 -3.4444884279512 9.02401971614574e-08 mirMAP -0.794984558850216 6.67646054442438e-12 NA NA NA hsa-miR-320a NTRK2 0.438165828017084 0.0390159073347133 -3.4444884279512 9.02401971614574e-08 mirMAP -0.708471038497037 2.00258734327495e-06 NA NA NA hsa-miR-320b NTRK2 1.55692969039548 1.41071034251915e-08 -3.4444884279512 9.02401971614574e-08 mirMAP -0.748159964114521 1.79959199577157e-11 NA NA NA hsa-miR-326 NTRK2 0.715313016136042 0.0610265683213359 -3.4444884279512 9.02401971614574e-08 miRanda -0.314908565253097 0.000146783251679974 NA NA NA hsa-miR-330-5p NTRK2 1.15100069700871 4.85551805046014e-07 -3.4444884279512 9.02401971614574e-08 miRanda -0.797396566610236 3.87824675584644e-09 NA NA NA hsa-miR-335-3p NTRK2 3.08791651139852 5.31309869723517e-12 -3.4444884279512 9.02401971614574e-08 mirMAP -0.325799033294531 1.77950710082574e-06 NA NA NA hsa-miR-335-5p NTRK2 1.77247705492746 2.22457658872091e-06 -3.4444884279512 9.02401971614574e-08 miRNAWalker2_validate -0.306339245672051 0.000234367118729164 NA NA NA hsa-miR-339-5p NTRK2 2.68710938429893 3.03134080808154e-16 -3.4444884279512 9.02401971614574e-08 miRanda -0.473102823273484 2.60419080375085e-07 NA NA NA hsa-miR-33a-5p NTRK2 3.79671563098419 1.15966309820345e-18 -3.4444884279512 9.02401971614574e-08 mirMAP -0.446714130551512 3.20996972838069e-09 NA NA NA hsa-miR-342-3p NTRK2 1.49115144672245 1.43879249744621e-07 -3.4444884279512 9.02401971614574e-08 miRanda -0.232236997607975 0.0357997421714086 NA NA NA hsa-miR-34a-3p NTRK2 1.75590866103657 8.02801510630657e-09 -3.4444884279512 9.02401971614574e-08 mirMAP -0.545493213319934 1.33340706209908e-06 NA NA NA hsa-miR-361-5p NTRK2 0.971859117235239 5.30236555707088e-09 -3.4444884279512 9.02401971614574e-08 miRanda;mirMAP -1.17870891609401 2.52271895231875e-10 NA NA NA hsa-miR-362-5p NTRK2 1.59303749908759 9.582675908797e-08 -3.4444884279512 9.02401971614574e-08 mirMAP -0.34256739087268 0.0010450304175508 NA NA NA hsa-miR-421 NTRK2 1.17791565395543 6.78526676976629e-06 -3.4444884279512 9.02401971614574e-08 mirMAP -0.388652077576734 0.00124164792398222 NA NA NA hsa-miR-429 NTRK2 4.48815175680773 2.44117492218206e-17 -3.4444884279512 9.02401971614574e-08 PITA;miRanda;miRNATAP -0.439212754909065 2.46588001463114e-15 NA NA NA hsa-miR-452-3p NTRK2 2.42521958420768 4.08754552781156e-07 -3.4444884279512 9.02401971614574e-08 mirMAP -0.16566953481693 0.0114315822356794 NA NA NA hsa-miR-454-3p NTRK2 2.47234127820054 1.12878018736016e-21 -3.4444884279512 9.02401971614574e-08 mirMAP -0.84994308142847 3.69480447340161e-13 NA NA NA hsa-miR-455-3p NTRK2 3.06093594997644 3.54590649799868e-16 -3.4444884279512 9.02401971614574e-08 mirMAP -0.417652226788031 2.01737423577491e-07 NA NA NA hsa-miR-501-5p NTRK2 1.93654809410041 1.3779381780759e-10 -3.4444884279512 9.02401971614574e-08 mirMAP -0.515062812169395 9.14107888272414e-07 NA NA NA hsa-miR-532-5p NTRK2 1.55697650978597 1.57884735535196e-11 -3.4444884279512 9.02401971614574e-08 PITA -0.662294968429731 6.6852568807782e-07 NA NA NA hsa-miR-576-5p NTRK2 2.20467023993664 3.4053475193793e-19 -3.4444884279512 9.02401971614574e-08 PITA;mirMAP -0.790847254437626 6.52457580482194e-11 NA NA NA hsa-miR-590-3p NTRK2 2.59289455139753 1.03200520972022e-21 -3.4444884279512 9.02401971614574e-08 PITA;miRanda;mirMAP -0.620306339153694 4.06542783004907e-08 NA NA NA hsa-miR-590-5p NTRK2 3.18300989862077 2.06813568597893e-26 -3.4444884279512 9.02401971614574e-08 miRanda;mirMAP -0.735662775454248 1.39412676341035e-13 NA NA NA hsa-miR-940 NTRK2 3.21011374578759 2.7923171128495e-14 -3.4444884279512 9.02401971614574e-08 PITA -0.574117798651102 9.91369577061371e-14 NA NA NA hsa-miR-17-5p OSM 3.2710598467455 9.93128340539455e-27 -0.423859851564122 0.347395185940331 TargetScan -0.252314193912872 0.000157125317137299 NA NA NA hsa-miR-185-3p OSM 2.3922478518806 1.3373426768452e-14 -0.423859851564122 0.347395185940331 MirTarget -0.245449571717484 0.000296196692609095 NA NA NA hsa-miR-320a OSM 0.438165828017084 0.0390159073347133 -0.423859851564122 0.347395185940331 miRanda -0.494774486571485 1.41633992871767e-06 NA NA NA hsa-miR-320b OSM 1.55692969039548 1.41071034251915e-08 -0.423859851564122 0.347395185940331 miRanda -0.346574888269941 8.37884026211797e-06 NA NA NA hsa-miR-590-5p OSM 3.18300989862077 2.06813568597893e-26 -0.423859851564122 0.347395185940331 miRanda -0.150988345659732 0.0322801586290005 NA NA NA hsa-miR-592 OSM 1.51765968871077 0.000636335248013204 -0.423859851564122 0.347395185940331 PITA;miRNATAP -0.167625684404534 0.000729098918317137 NA NA NA hsa-let-7a-5p OSMR 0.618599506841644 2.76973453058748e-05 -1.0998277332942 0.0198562724114004 TargetScan;miRNATAP -0.435560455188278 0.00563783241553846 NA NA NA hsa-let-7d-5p OSMR 1.33236798905207 1.1741085658466e-13 -1.0998277332942 0.0198562724114004 miRNATAP -1.06827084197869 6.31274876774818e-19 NA NA NA hsa-let-7e-5p OSMR 0.860104282510173 6.04758298373779e-05 -1.0998277332942 0.0198562724114004 miRNATAP -0.654114471448548 4.44852647779445e-10 NA NA NA hsa-let-7f-5p OSMR 0.495648727272215 0.00355972741198794 -1.0998277332942 0.0198562724114004 miRNATAP -0.586100924792049 1.51731733325993e-05 NA NA NA hsa-let-7g-5p OSMR 1.20061455355116 1.50237505511483e-12 -1.0998277332942 0.0198562724114004 miRNATAP -1.34131322486179 9.42025268127223e-27 NA NA NA hsa-miR-196b-5p OSMR 1.71646270856386 4.37735885910369e-09 -1.0998277332942 0.0198562724114004 miRNATAP -0.459754615555367 1.259359786718e-09 NA NA NA hsa-miR-200b-3p OSMR 3.78235093249346 3.18343003239465e-14 -1.0998277332942 0.0198562724114004 TargetScan -0.502111510374442 1.23957799885379e-34 NA NA NA hsa-miR-335-5p OSMR 1.77247705492746 2.22457658872091e-06 -1.0998277332942 0.0198562724114004 miRNAWalker2_validate -0.418785334592353 1.1578162031017e-12 NA NA NA hsa-miR-362-3p OSMR 2.0756816987665 3.89026064579331e-12 -1.0998277332942 0.0198562724114004 miRanda -0.28487700645003 0.000213859328208725 NA NA NA hsa-miR-374a-5p OSMR 0.484615721953736 0.0042981729815149 -1.0998277332942 0.0198562724114004 mirMAP -0.488024666243276 0.000341295244550417 NA NA NA hsa-miR-429 OSMR 4.48815175680773 2.44117492218206e-17 -1.0998277332942 0.0198562724114004 miRanda;miRNATAP -0.462497233544422 1.15192786178869e-33 NA NA NA hsa-miR-542-3p OSMR 1.18832665895751 1.98700670691565e-07 -1.0998277332942 0.0198562724114004 miRanda -0.296627018520046 0.00283375508696947 NA NA NA hsa-miR-590-3p OSMR 2.59289455139753 1.03200520972022e-21 -1.0998277332942 0.0198562724114004 miRanda;mirMAP;miRNATAP -0.307225685485741 0.000195518179718753 NA NA NA hsa-miR-98-5p OSMR 1.11154309866014 1.24143909012085e-08 -1.0998277332942 0.0198562724114004 miRNAWalker2_validate -1.16917812588748 1.38043593831239e-26 NA NA NA hsa-miR-590-3p PCK1 2.59289455139753 1.03200520972022e-21 -2.06269265753178 0.00169206548096617 miRanda -0.276917622037436 0.0166313865515317 NA NA NA hsa-let-7d-5p PDGFA 1.33236798905207 1.1741085658466e-13 -0.102054427352152 0.706957288628846 miRNAWalker2_validate -0.151126243325164 0.0355501771050966 NA NA NA hsa-miR-320b PDGFA 1.55692969039548 1.41071034251915e-08 -0.102054427352152 0.706957288628846 miRanda -0.127864638339372 0.00663582990083202 NA NA NA hsa-miR-331-5p PDGFA 2.17414714166315 1.54547681391888e-18 -0.102054427352152 0.706957288628846 PITA;miRNATAP -0.160783001474425 0.00212874646023858 NA NA NA hsa-miR-421 PDGFA 1.17791565395543 6.78526676976629e-06 -0.102054427352152 0.706957288628846 miRanda -0.169357059547879 0.000668658673908117 NA NA NA hsa-miR-484 PDGFA 1.81844463411787 1.82951571230938e-15 -0.102054427352152 0.706957288628846 PITA;miRNATAP -0.163420399065966 0.00333081226843222 NA NA NA hsa-miR-576-5p PDGFA 2.20467023993664 3.4053475193793e-19 -0.102054427352152 0.706957288628846 mirMAP -0.110897088111662 0.0304652485803866 NA NA NA hsa-miR-590-3p PDGFA 2.59289455139753 1.03200520972022e-21 -0.102054427352152 0.706957288628846 miRanda -0.133975078033997 0.0047011572526004 NA NA NA hsa-miR-590-5p PDGFA 3.18300989862077 2.06813568597893e-26 -0.102054427352152 0.706957288628846 miRanda -0.136216823398504 0.00126211188867757 NA NA NA hsa-let-7a-5p PDGFB 0.618599506841644 2.76973453058748e-05 0.496610054270869 0.0653962924185686 TargetScan;miRNATAP -0.34611820876839 0.000105030069604701 NA NA NA hsa-let-7b-5p PDGFB 0.604314269683977 0.00140009936153214 0.496610054270869 0.0653962924185686 miRNATAP -0.160034835087363 0.0214264705549021 NA NA NA hsa-let-7d-5p PDGFB 1.33236798905207 1.1741085658466e-13 0.496610054270869 0.0653962924185686 miRNATAP -0.147037998383522 0.0398112072883611 NA NA NA hsa-let-7f-5p PDGFB 0.495648727272215 0.00355972741198794 0.496610054270869 0.0653962924185686 miRNATAP -0.230786895213123 0.00294626570770709 NA NA NA hsa-let-7g-5p PDGFB 1.20061455355116 1.50237505511483e-12 0.496610054270869 0.0653962924185686 miRNATAP -0.228771312890516 0.00256055086878667 NA NA NA hsa-miR-26b-5p PDGFB 0.885393662798425 3.2116297961629e-06 0.496610054270869 0.0653962924185686 miRNAWalker2_validate -0.13628073651007 0.047564711202645 NA NA NA hsa-miR-29b-2-5p PDGFB 0.910668640983475 0.00666655585493488 0.496610054270869 0.0653962924185686 mirMAP -0.139091152849383 0.000325402180502362 NA NA NA hsa-miR-29c-3p PDGFB -0.00968972577705429 0.97099586346872 0.496610054270869 0.0653962924185686 MirTarget;miRNATAP -0.136061870879976 0.00568361134251952 NA NA NA hsa-miR-421 PDGFB 1.17791565395543 6.78526676976629e-06 0.496610054270869 0.0653962924185686 mirMAP -0.116368529046944 0.0192055071821096 NA NA NA hsa-miR-16-2-3p PDGFC 2.31623086727196 4.29838149388188e-20 -1.35193216344973 0.000222396841108038 mirMAP -0.381970075069368 1.03844682897972e-08 NA NA NA hsa-miR-330-3p PDGFC 0.876747334239085 0.00073709016089703 -1.35193216344973 0.000222396841108038 mirMAP -0.513212595408201 1.24081468442561e-14 NA NA NA hsa-miR-330-5p PDGFC 1.15100069700871 4.85551805046014e-07 -1.35193216344973 0.000222396841108038 miRanda -0.468820563713005 7.20271419938696e-10 NA NA NA hsa-miR-335-3p PDGFC 3.08791651139852 5.31309869723517e-12 -1.35193216344973 0.000222396841108038 mirMAP -0.235349925814362 6.22897769137172e-10 NA NA NA hsa-miR-3607-3p PDGFC 2.68532138541128 5.66716351955047e-14 -1.35193216344973 0.000222396841108038 mirMAP -0.285687710966463 5.32070657766311e-09 NA NA NA hsa-miR-361-5p PDGFC 0.971859117235239 5.30236555707088e-09 -1.35193216344973 0.000222396841108038 miRanda -0.833081202036927 7.87976775653925e-16 NA NA NA hsa-miR-421 PDGFC 1.17791565395543 6.78526676976629e-06 -1.35193216344973 0.000222396841108038 miRanda -0.351311206292076 1.63831209098356e-07 NA NA NA hsa-miR-486-5p PDGFC -0.194913133034028 0.607377798807705 -1.35193216344973 0.000222396841108038 miRanda -0.178753024306378 0.000136764659737303 NA NA NA hsa-miR-582-3p PDGFC 0.00876844181512659 0.977126166214707 -1.35193216344973 0.000222396841108038 PITA -0.270308220423039 3.19238038538228e-06 NA NA NA hsa-miR-590-3p PDGFC 2.59289455139753 1.03200520972022e-21 -1.35193216344973 0.000222396841108038 PITA;miRanda;mirMAP -0.362163122053015 1.207543102597e-08 NA NA NA hsa-miR-7-1-3p PDGFC 1.84950311431067 1.25300363397654e-13 -1.35193216344973 0.000222396841108038 mirMAP -0.308615311749286 8.0769094309117e-06 NA NA NA hsa-miR-944 PDGFC 2.91186649218281 1.31574753528144e-06 -1.35193216344973 0.000222396841108038 mirMAP -0.231401333838594 2.34241674181651e-15 NA NA NA hsa-miR-19b-1-5p PDGFD 2.57951428759379 4.31576118703427e-20 -2.21895974366423 9.8844535062016e-11 MirTarget -0.371069183482093 1.91682488089415e-10 NA NA NA hsa-miR-21-5p PDGFD 2.73773305747971 1.38864982139576e-43 -2.21895974366423 9.8844535062016e-11 miRNAWalker2_validate -0.550873661766527 3.68515951748985e-13 NA NA NA hsa-miR-320b PDGFD 1.55692969039548 1.41071034251915e-08 -2.21895974366423 9.8844535062016e-11 miRanda -0.182874490877128 0.00270207482500816 NA NA NA hsa-miR-331-5p PDGFD 2.17414714166315 1.54547681391888e-18 -2.21895974366423 9.8844535062016e-11 MirTarget -0.434379532111514 6.49776221649418e-11 NA NA NA hsa-miR-590-3p PDGFD 2.59289455139753 1.03200520972022e-21 -2.21895974366423 9.8844535062016e-11 miRanda;mirMAP;miRNATAP -0.410508831975381 7.9308556547056e-12 NA NA NA hsa-miR-590-5p PDGFD 3.18300989862077 2.06813568597893e-26 -2.21895974366423 9.8844535062016e-11 miRanda -0.358503417217371 2.33094792409083e-11 NA NA NA hsa-miR-7-1-3p PDGFD 1.84950311431067 1.25300363397654e-13 -2.21895974366423 9.8844535062016e-11 mirMAP -0.328505748297511 5.62247042199189e-07 NA NA NA hsa-miR-944 PDGFD 2.91186649218281 1.31574753528144e-06 -2.21895974366423 9.8844535062016e-11 MirTarget;mirMAP -0.207430129373809 1.1380429140574e-13 NA NA NA hsa-let-7a-3p PDGFRA 1.42015538786275 7.03375209382654e-13 -2.37640583073564 1.39737819859365e-09 mirMAP -0.548764001510131 6.84820893227166e-09 NA NA NA hsa-let-7b-3p PDGFRA 0.868207752019623 1.30460056774366e-05 -2.37640583073564 1.39737819859365e-09 mirMAP -0.344538450812629 0.000386110125844406 NA NA NA hsa-let-7b-5p PDGFRA 0.604314269683977 0.00140009936153214 -2.37640583073564 1.39737819859365e-09 miRNAWalker2_validate -0.521190235799922 3.3085772165913e-07 NA NA NA hsa-let-7f-1-3p PDGFRA 1.55054488387679 7.31326775537952e-11 -2.37640583073564 1.39737819859365e-09 mirMAP -0.255636194946609 0.00187448794686435 NA NA NA hsa-let-7g-3p PDGFRA 3.26398061402445 3.96263126107645e-25 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.513984859053283 2.05725197047486e-19 NA NA NA hsa-miR-106a-5p PDGFRA 2.48882002962836 1.99757727374521e-12 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.371298633316283 8.91032038900892e-13 NA NA NA hsa-miR-106b-5p PDGFRA 2.46782146831112 1.36171495805632e-23 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.735956870099196 1.34297971882591e-25 NA NA NA hsa-miR-125a-3p PDGFRA 1.24490295132072 5.26925231010328e-06 -2.37640583073564 1.39737819859365e-09 miRanda -0.147350764504837 0.0368213926583983 NA NA NA hsa-miR-129-5p PDGFRA -0.524170159980738 0.222582956006346 -2.37640583073564 1.39737819859365e-09 miRanda;mirMAP;miRNATAP -0.128621152047043 0.0051316212954247 NA NA NA hsa-miR-130a-3p PDGFRA 2.02021855058359 1.26427102520415e-11 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.233330487651072 0.000224564945662775 NA NA NA hsa-miR-130b-3p PDGFRA 3.5350292994509 1.73934183852569e-27 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.443010230539233 1.9085252314885e-16 NA NA NA hsa-miR-141-3p PDGFRA 5.02396127982626 2.19224509139725e-24 -2.37640583073564 1.39737819859365e-09 MirTarget -0.379513640202387 7.11112956696243e-28 NA NA NA hsa-miR-149-5p PDGFRA 2.94200492826326 4.93436498919036e-14 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.2660799579696 1.94629645007035e-08 NA NA NA hsa-miR-16-1-3p PDGFRA 2.56983217111073 3.02262181237943e-20 -2.37640583073564 1.39737819859365e-09 MirTarget -0.523089278771913 2.57639641644736e-15 NA NA NA hsa-miR-17-5p PDGFRA 3.2710598467455 9.93128340539455e-27 -2.37640583073564 1.39737819859365e-09 MirTarget;TargetScan;miRNATAP -0.553748753585946 1.23397121105114e-22 NA NA NA hsa-miR-181a-5p PDGFRA 2.29556023480783 1.8138457900616e-21 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.163489892359901 0.0334238760202475 NA NA NA hsa-miR-181b-5p PDGFRA 2.49307679431293 3.92829250217627e-20 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.246762118189355 0.000291477558580384 NA NA NA hsa-miR-181c-5p PDGFRA 1.58587920618301 1.57506918816933e-10 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.154510387774745 0.044722673902946 NA NA NA hsa-miR-181d-5p PDGFRA 1.52204912185579 9.2693319057748e-08 -2.37640583073564 1.39737819859365e-09 MirTarget -0.145317773745093 0.0309239355346582 NA NA NA hsa-miR-182-5p PDGFRA 3.53923166221814 5.07781258121574e-21 -2.37640583073564 1.39737819859365e-09 miRNATAP -0.375439590705967 2.48477058044486e-15 NA NA NA hsa-miR-186-5p PDGFRA 1.47445398888668 3.0781726595413e-15 -2.37640583073564 1.39737819859365e-09 MirTarget -0.700421064109499 1.35088148765239e-12 NA NA NA hsa-miR-196a-5p PDGFRA 1.52993069622497 0.00397268663639603 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.124523334352829 0.000586053454058574 NA NA NA hsa-miR-196b-5p PDGFRA 1.71646270856386 4.37735885910369e-09 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.290309745460117 7.22286389037591e-06 NA NA NA hsa-miR-200a-3p PDGFRA 4.59434485520731 6.38952518573476e-18 -2.37640583073564 1.39737819859365e-09 MirTarget -0.30020684009978 2.24739680558458e-19 NA NA NA hsa-miR-20a-5p PDGFRA 3.15577933619191 4.19753346442454e-25 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.536531231590286 6.48676718494673e-21 NA NA NA hsa-miR-20b-5p PDGFRA 2.07706563022469 1.10107236083433e-05 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.200276264854919 5.98530623190359e-07 NA NA NA hsa-miR-2110 PDGFRA 1.16625590651194 6.4784195289885e-05 -2.37640583073564 1.39737819859365e-09 MirTarget -0.367427900079696 1.6178582537556e-07 NA NA NA hsa-miR-224-5p PDGFRA 2.94107125335675 5.72194099515157e-08 -2.37640583073564 1.39737819859365e-09 MirTarget -0.18329230997559 1.26828530884065e-07 NA NA NA hsa-miR-24-3p PDGFRA 0.99989036772428 1.35595013650376e-07 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.445666887182499 1.04888902991557e-05 NA NA NA hsa-miR-26b-5p PDGFRA 0.885393662798425 3.2116297961629e-06 -2.37640583073564 1.39737819859365e-09 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.434540118830339 1.79640152621153e-05 NA NA NA hsa-miR-27a-3p PDGFRA 1.66542180327138 4.93775737894805e-13 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.231732831890339 0.00480656820974615 NA NA NA hsa-miR-29b-2-5p PDGFRA 0.910668640983475 0.00666655585493488 -2.37640583073564 1.39737819859365e-09 mirMAP -0.249967909040798 1.27931881284481e-05 NA NA NA hsa-miR-29b-3p PDGFRA 1.65828197923813 1.02676780888141e-09 -2.37640583073564 1.39737819859365e-09 MirTarget -0.200668467003426 0.00420946019654394 NA NA NA hsa-miR-301a-3p PDGFRA 2.81024345929638 2.29784847962242e-17 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.508684565933966 4.36558822645561e-19 NA NA NA hsa-miR-3065-5p PDGFRA 2.74629919868982 1.86846589298284e-08 -2.37640583073564 1.39737819859365e-09 mirMAP -0.166254695248905 0.00048554613178076 NA NA NA hsa-miR-320a PDGFRA 0.438165828017084 0.0390159073347133 -2.37640583073564 1.39737819859365e-09 miRanda -0.402889384468968 1.02856691876917e-05 NA NA NA hsa-miR-320b PDGFRA 1.55692969039548 1.41071034251915e-08 -2.37640583073564 1.39737819859365e-09 miRanda -0.519602099473307 1.42131525257444e-14 NA NA NA hsa-miR-330-5p PDGFRA 1.15100069700871 4.85551805046014e-07 -2.37640583073564 1.39737819859365e-09 miRanda -0.45163495328704 5.41294182541652e-08 NA NA NA hsa-miR-335-3p PDGFRA 3.08791651139852 5.31309869723517e-12 -2.37640583073564 1.39737819859365e-09 mirMAP -0.14687583518123 0.000466962608053098 NA NA NA hsa-miR-339-5p PDGFRA 2.68710938429893 3.03134080808154e-16 -2.37640583073564 1.39737819859365e-09 miRanda -0.338543405646925 1.34989847950552e-09 NA NA NA hsa-miR-33a-5p PDGFRA 3.79671563098419 1.15966309820345e-18 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.396871470489045 1.19728989197256e-18 NA NA NA hsa-miR-34a-5p PDGFRA 1.9016323452565 1.43092834643601e-14 -2.37640583073564 1.39737819859365e-09 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.295453243484317 9.87541559838975e-05 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-34c-5p PDGFRA 2.07190852984647 7.35776320806257e-08 -2.37640583073564 1.39737819859365e-09 MirTarget;PITA;miRanda;miRNATAP -0.225762830573297 1.74081263395182e-05 NA NA NA hsa-miR-362-3p PDGFRA 2.0756816987665 3.89026064579331e-12 -2.37640583073564 1.39737819859365e-09 miRanda -0.2120805244561 0.00115047466173652 NA NA NA hsa-miR-374a-5p PDGFRA 0.484615721953736 0.0042981729815149 -2.37640583073564 1.39737819859365e-09 mirMAP -0.336442959314977 0.00360859152849973 NA NA NA hsa-miR-421 PDGFRA 1.17791565395543 6.78526676976629e-06 -2.37640583073564 1.39737819859365e-09 PITA;miRanda;miRNATAP -0.474589953500027 4.96575533912116e-11 NA NA NA hsa-miR-429 PDGFRA 4.48815175680773 2.44117492218206e-17 -2.37640583073564 1.39737819859365e-09 miRanda;miRNATAP -0.283783064999005 4.47719067465487e-17 NA NA NA hsa-miR-450b-5p PDGFRA 1.69244418548325 1.68064054148881e-10 -2.37640583073564 1.39737819859365e-09 mirMAP -0.147998086766377 0.0396354356204566 NA NA NA hsa-miR-454-3p PDGFRA 2.47234127820054 1.12878018736016e-21 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.54069398402006 3.51649522550592e-14 NA NA NA hsa-miR-491-5p PDGFRA 0.615770352820862 0.0418295628761654 -2.37640583073564 1.39737819859365e-09 MirTarget;PITA;miRanda;miRNATAP -0.259675783066868 0.000149579704439114 NA NA NA hsa-miR-550a-5p PDGFRA 2.11025227932763 6.94489556637146e-12 -2.37640583073564 1.39737819859365e-09 MirTarget -0.450686953718593 5.51129161245862e-14 NA NA NA hsa-miR-576-5p PDGFRA 2.20467023993664 3.4053475193793e-19 -2.37640583073564 1.39737819859365e-09 mirMAP -0.494558915423906 2.30135204635613e-11 NA NA NA hsa-miR-589-3p PDGFRA 2.51971841868825 2.39125940264107e-11 -2.37640583073564 1.39737819859365e-09 mirMAP -0.375875993689772 1.70404670310081e-11 NA NA NA hsa-miR-590-3p PDGFRA 2.59289455139753 1.03200520972022e-21 -2.37640583073564 1.39737819859365e-09 miRanda;mirMAP -0.493181031896196 4.96463414718196e-13 NA NA NA hsa-miR-590-5p PDGFRA 3.18300989862077 2.06813568597893e-26 -2.37640583073564 1.39737819859365e-09 miRanda -0.507406338027508 3.77905121698734e-17 NA NA NA hsa-miR-664a-3p PDGFRA 0.634721925861133 0.00520070178640421 -2.37640583073564 1.39737819859365e-09 mirMAP -0.190814931098414 0.0260959619653899 NA NA NA hsa-miR-7-1-3p PDGFRA 1.84950311431067 1.25300363397654e-13 -2.37640583073564 1.39737819859365e-09 mirMAP -0.533746456815578 4.42305082401204e-13 NA NA NA hsa-miR-93-5p PDGFRA 3.03961860136032 1.11672209617395e-24 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.564676380038124 7.42892698232966e-22 NA NA NA hsa-miR-944 PDGFRA 2.91186649218281 1.31574753528144e-06 -2.37640583073564 1.39737819859365e-09 mirMAP -0.271450894098107 7.2626459248576e-18 NA NA NA hsa-miR-96-5p PDGFRA 4.89433085814374 1.92000659886961e-31 -2.37640583073564 1.39737819859365e-09 TargetScan;miRNATAP -0.372021838983214 1.0707043407444e-18 NA NA NA hsa-miR-224-5p PDGFRB 2.94107125335675 5.72194099515157e-08 -1.03522303801072 0.00301738788961229 miRNAWalker2_validate -0.147943334000896 1.16237114575095e-06 NA NA NA hsa-miR-24-3p PDGFRB 0.99989036772428 1.35595013650376e-07 -1.03522303801072 0.00301738788961229 MirTarget -0.297654000867495 0.000814454894038923 NA NA NA hsa-miR-28-5p PDGFRB 0.230152919654905 0.0742909586754846 -1.03522303801072 0.00301738788961229 miRanda -0.303906959694572 0.0253692848961482 NA NA NA hsa-miR-29b-3p PDGFRB 1.65828197923813 1.02676780888141e-09 -1.03522303801072 0.00301738788961229 miRNATAP -0.292671948645054 1.48415268440158e-06 NA NA NA hsa-miR-29c-3p PDGFRB -0.00968972577705429 0.97099586346872 -1.03522303801072 0.00301738788961229 miRNATAP -0.359274369001045 1.19150158465265e-08 NA NA NA hsa-miR-3127-5p PDGFRB 1.51846438737133 3.59571251672767e-07 -1.03522303801072 0.00301738788961229 mirMAP -0.437942367228042 7.35571780732733e-16 NA NA NA hsa-miR-34a-5p PDGFRB 1.9016323452565 1.43092834643601e-14 -1.03522303801072 0.00301738788961229 MirTarget -0.3682858109356 2.13745951637981e-08 24837198 MicroRNA 34A inhibits the growth invasion and metastasis of gastric cancer by targeting PDGFR and MET expression; In this study our aim was to identify the miRNAs that target PDGFR-α/β and to study the functions of these miRNAs miR-34a was predicted to target PDGFR and luciferase reporter assays showed that miR-34a could directly target PDGFR; Moreover the cancer-associated cell signalling pathway was studied and we found that miR-34a could inhibit Akt PKB protein kinase B phosphorylation which was restored by the overexpression of both PDGFR and MET; In conclusion miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K phosphoinositide 3-kinase/Akt pathway metastasis gastric cancer hsa-miR-361-3p PDGFRB 1.07367425434318 1.73142774168958e-09 -1.03522303801072 0.00301738788961229 MirTarget -0.272631369423021 0.00390272618180474 NA NA NA hsa-miR-421 PDGFRB 1.17791565395543 6.78526676976629e-06 -1.03522303801072 0.00301738788961229 miRanda -0.344304119846965 6.47537980961128e-08 NA NA NA hsa-miR-484 PDGFRB 1.81844463411787 1.82951571230938e-15 -1.03522303801072 0.00301738788961229 mirMAP -0.430712318832622 1.16944218559625e-09 NA NA NA hsa-miR-486-5p PDGFRB -0.194913133034028 0.607377798807705 -1.03522303801072 0.00301738788961229 miRanda -0.172192912820644 0.000110418260727812 NA NA NA hsa-miR-491-5p PDGFRB 0.615770352820862 0.0418295628761654 -1.03522303801072 0.00301738788961229 miRanda -0.236736729792446 7.68579463655803e-05 NA NA NA hsa-miR-664a-3p PDGFRB 0.634721925861133 0.00520070178640421 -1.03522303801072 0.00301738788961229 MirTarget -0.524307398841617 6.92902562319671e-13 NA NA NA hsa-miR-9-5p PDGFRB 1.02304182473283 0.042901377604859 -1.03522303801072 0.00301738788961229 MirTarget;miRNATAP -0.128055325842353 0.000120423195513495 NA NA NA hsa-miR-186-5p PDPK1 1.47445398888668 3.0781726595413e-15 -0.446682027133002 0.00835125010618968 mirMAP -0.125708876159213 0.00333632806915964 NA NA NA hsa-miR-22-5p PDPK1 1.88011544159252 1.63978222572222e-16 -0.446682027133002 0.00835125010618968 miRNATAP -0.181020438712566 1.45237356289081e-07 NA NA NA hsa-miR-29b-3p PDPK1 1.65828197923813 1.02676780888141e-09 -0.446682027133002 0.00835125010618968 mirMAP -0.109518325633884 0.000211964623360266 NA NA NA hsa-miR-342-3p PDPK1 1.49115144672245 1.43879249744621e-07 -0.446682027133002 0.00835125010618968 mirMAP -0.109793629457974 0.000113758361154384 NA NA NA hsa-miR-374a-3p PDPK1 0.533309330504947 0.00192918429705142 -0.446682027133002 0.00835125010618968 mirMAP -0.118308754113252 0.0142261349514195 NA NA NA hsa-miR-326 PGF 0.715313016136042 0.0610265683213359 0.82580882918736 0.0169544692696931 mirMAP -0.162219493325868 0.000221458535925083 NA NA NA hsa-miR-421 PGF 1.17791565395543 6.78526676976629e-06 0.82580882918736 0.0169544692696931 miRanda -0.141102218221589 0.0272665155908835 NA NA NA hsa-miR-299-5p PHLPP1 -0.274550626427337 0.386834031856446 -0.292095853114944 0.192125506863847 miRNATAP -0.149254831651348 1.18901275295714e-05 NA NA NA hsa-miR-29b-1-5p PHLPP1 1.55384379072167 4.76870585070176e-05 -0.292095853114944 0.192125506863847 MirTarget -0.15653606762384 1.05139683470078e-07 NA NA NA hsa-miR-338-5p PHLPP1 -0.577691606146419 0.0472212680542825 -0.292095853114944 0.192125506863847 MirTarget;miRNATAP -0.155775292660067 3.01438921084596e-05 NA NA NA hsa-miR-34c-3p PHLPP1 2.41359195938096 3.46966584087088e-10 -0.292095853114944 0.192125506863847 MirTarget -0.109629221910218 0.000115122331015189 NA NA NA hsa-miR-511-5p PHLPP1 1.04499312543772 0.00234126154508174 -0.292095853114944 0.192125506863847 MirTarget -0.200850250098172 6.97404653707961e-11 NA NA NA hsa-miR-10b-3p PHLPP2 0.77597971642517 0.00264877454133753 -0.542526414508152 0.00198752699211246 miRNATAP -0.14178645981328 1.49956903561695e-05 NA NA NA hsa-miR-141-3p PHLPP2 5.02396127982626 2.19224509139725e-24 -0.542526414508152 0.00198752699211246 MirTarget;TargetScan;miRNATAP -0.104884442280012 4.29809622480929e-11 24945731 MicroRNA 141 promotes the proliferation of non small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2; Together the results of this study suggest that miR-141 and its targets PHLPP1 and PHLPP2 play critical roles in NSCLC tumorigenesis and provide potential therapeutic targets for NSCLC treatment tumorigenesis lung squamous cell cancer hsa-miR-141-5p PHLPP2 3.81419396518882 3.21977359736126e-18 -0.542526414508152 0.00198752699211246 MirTarget -0.104201785756358 1.26649431569853e-08 24945731 MicroRNA 141 promotes the proliferation of non small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2; Together the results of this study suggest that miR-141 and its targets PHLPP1 and PHLPP2 play critical roles in NSCLC tumorigenesis and provide potential therapeutic targets for NSCLC treatment tumorigenesis lung squamous cell cancer hsa-miR-15a-5p PHLPP2 2.34669284378787 1.69544424500258e-23 -0.542526414508152 0.00198752699211246 MirTarget;miRNATAP -0.1340976362243 9.13342724833571e-05 NA NA NA hsa-miR-186-5p PHLPP2 1.47445398888668 3.0781726595413e-15 -0.542526414508152 0.00198752699211246 mirMAP -0.103780678386306 0.0197937459867812 NA NA NA hsa-miR-19b-3p PHLPP2 2.49529833021187 1.57028265846699e-23 -0.542526414508152 0.00198752699211246 mirMAP -0.107477482973918 0.000876096992851489 NA NA NA hsa-miR-20a-5p PHLPP2 3.15577933619191 4.19753346442454e-25 -0.542526414508152 0.00198752699211246 miRNATAP -0.106106225323319 5.04216763751669e-05 NA NA NA hsa-miR-26b-5p PHLPP2 0.885393662798425 3.2116297961629e-06 -0.542526414508152 0.00198752699211246 miRNAWalker2_validate -0.199324419911432 7.2830835180397e-06 NA NA NA hsa-miR-27a-3p PHLPP2 1.66542180327138 4.93775737894805e-13 -0.542526414508152 0.00198752699211246 MirTarget;miRNATAP -0.14780267270227 3.82139930876315e-05 NA NA NA hsa-miR-27b-3p PHLPP2 0.196007704287769 0.295630157035388 -0.542526414508152 0.00198752699211246 MirTarget;miRNATAP -0.119293139380493 0.00955119674767794 NA NA NA hsa-miR-29b-3p PHLPP2 1.65828197923813 1.02676780888141e-09 -0.542526414508152 0.00198752699211246 miRNATAP -0.14245483567117 3.09046496600119e-06 NA NA NA hsa-miR-425-5p PHLPP2 3.07071373939774 4.02947460586085e-25 -0.542526414508152 0.00198752699211246 mirMAP -0.109392010640829 4.82239007027023e-05 NA NA NA hsa-miR-92a-3p PHLPP2 2.06460102658973 1.44784291084757e-19 -0.542526414508152 0.00198752699211246 MirTarget;miRNATAP -0.111596867827293 0.0018210649922823 NA NA NA hsa-miR-106b-5p PIK3AP1 2.46782146831112 1.36171495805632e-23 -0.459059440376337 0.265936020481245 miRNAWalker2_validate -0.490836008804642 7.21155110052172e-11 NA NA NA hsa-miR-107 PIK3AP1 1.30977326593435 1.30372468603965e-11 -0.459059440376337 0.265936020481245 miRanda -0.462565384411159 4.51028690253635e-06 NA NA NA hsa-miR-182-5p PIK3AP1 3.53923166221814 5.07781258121574e-21 -0.459059440376337 0.265936020481245 MirTarget -0.391785355726999 9.99609004314833e-16 NA NA NA hsa-miR-25-3p PIK3AP1 1.36472605225697 4.83790725935681e-11 -0.459059440376337 0.265936020481245 MirTarget -0.284087225869249 0.00269141049066745 NA NA NA hsa-miR-30d-3p PIK3AP1 0.977747550180601 4.3048212205381e-05 -0.459059440376337 0.265936020481245 miRNATAP -0.59426259923785 2.44643832321597e-13 NA NA NA hsa-miR-363-3p PIK3AP1 1.50575300026701 0.00020976164678918 -0.459059440376337 0.265936020481245 MirTarget -0.122016541405911 0.0125171885506492 NA NA NA hsa-miR-421 PIK3AP1 1.17791565395543 6.78526676976629e-06 -0.459059440376337 0.265936020481245 miRanda -0.160576756654002 0.0348321053537024 NA NA NA hsa-miR-582-5p PIK3AP1 0.609226359812689 0.032988717891497 -0.459059440376337 0.265936020481245 MirTarget -0.43312582183605 2.79217065572693e-10 NA NA NA hsa-miR-92a-3p PIK3AP1 2.06460102658973 1.44784291084757e-19 -0.459059440376337 0.265936020481245 MirTarget -0.354763063092096 2.17628619777572e-05 NA NA NA hsa-miR-940 PIK3AP1 3.21011374578759 2.7923171128495e-14 -0.459059440376337 0.265936020481245 MirTarget -0.383742552798826 2.18548461615148e-15 NA NA NA hsa-miR-126-5p PIK3CA 0.895338176458417 2.33372756450713e-05 -0.151828236462886 0.321284398928338 mirMAP -0.103377544898631 0.00298975306098663 NA NA NA hsa-miR-186-5p PIK3CA 1.47445398888668 3.0781726595413e-15 -0.151828236462886 0.321284398928338 mirMAP -0.101671973753504 0.00842161241015832 NA NA NA hsa-miR-320a PIK3CA 0.438165828017084 0.0390159073347133 -0.151828236462886 0.321284398928338 miRanda -0.153857910084833 9.6763748473785e-06 NA NA NA hsa-miR-10b-5p PIK3CD -0.155951595811628 0.555006386998027 -0.775351667927902 0.021645534884375 miRNAWalker2_validate -0.175760207889201 0.004748835358114 NA NA NA hsa-miR-1468-5p PIK3CD 0.0469536064343461 0.881810795145912 -0.775351667927902 0.021645534884375 MirTarget -0.223784917601258 1.49208556354691e-05 NA NA NA hsa-miR-29c-3p PIK3CD -0.00968972577705429 0.97099586346872 -0.775351667927902 0.021645534884375 mirMAP -0.250794863940076 4.41169066967662e-05 NA NA NA hsa-miR-30b-3p PIK3CD 0.834142820354026 0.000972582820878813 -0.775351667927902 0.021645534884375 MirTarget -0.531045557079738 2.22640594160628e-17 NA NA NA hsa-miR-30b-5p PIK3CD 0.800822374912712 0.000133601914525413 -0.775351667927902 0.021645534884375 MirTarget -0.411457344396036 9.99002635635066e-08 NA NA NA hsa-miR-30c-5p PIK3CD 0.778774633108 0.000285599212429136 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.461850084291099 7.5210996634642e-10 NA NA NA hsa-miR-30d-5p PIK3CD 0.675423997639582 0.00270618816039773 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.733785480070449 9.30689014359708e-27 NA NA NA hsa-miR-30e-5p PIK3CD 1.23904909539663 1.35561917122157e-09 -0.775351667927902 0.021645534884375 MirTarget -0.597650735147178 7.00788139486401e-15 NA NA NA hsa-miR-320a PIK3CD 0.438165828017084 0.0390159073347133 -0.775351667927902 0.021645534884375 miRanda -0.437629854617933 1.07773535518864e-08 NA NA NA hsa-miR-320b PIK3CD 1.55692969039548 1.41071034251915e-08 -0.775351667927902 0.021645534884375 miRanda -0.282783919094812 1.19379715607107e-06 NA NA NA hsa-miR-324-5p PIK3CD 2.95683728155095 1.32960514360912e-20 -0.775351667927902 0.021645534884375 miRanda -0.265511883710764 4.30342749668002e-08 NA NA NA hsa-miR-3913-5p PIK3CD 2.44353493655328 8.95279496632448e-15 -0.775351667927902 0.021645534884375 mirMAP -0.395313104822511 3.24743386923115e-15 NA NA NA hsa-miR-421 PIK3CD 1.17791565395543 6.78526676976629e-06 -0.775351667927902 0.021645534884375 miRanda -0.235490163150307 0.000146542275873157 NA NA NA hsa-miR-484 PIK3CD 1.81844463411787 1.82951571230938e-15 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.387158078139352 1.61214627982237e-08 NA NA NA hsa-miR-148b-3p PIK3CG 1.97815018171325 6.07715327281595e-26 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.598035215538084 7.05982657783629e-10 NA NA NA hsa-miR-26b-5p PIK3CG 0.885393662798425 3.2116297961629e-06 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.252635166842034 0.0140326902426817 NA NA NA hsa-miR-335-3p PIK3CG 3.08791651139852 5.31309869723517e-12 -1.04493260087656 0.00941484120426313 mirMAP -0.182751911295676 1.44284270796844e-05 NA NA NA hsa-miR-3607-3p PIK3CG 2.68532138541128 5.66716351955047e-14 -1.04493260087656 0.00941484120426313 mirMAP -0.166734433414221 0.00216182223501734 NA NA NA hsa-miR-421 PIK3CG 1.17791565395543 6.78526676976629e-06 -1.04493260087656 0.00941484120426313 miRanda -0.208294811185602 0.00505346682917229 NA NA NA hsa-miR-590-3p PIK3CG 2.59289455139753 1.03200520972022e-21 -1.04493260087656 0.00941484120426313 miRanda -0.160421801003692 0.0232620908281926 NA NA NA hsa-miR-101-5p PIK3R1 0.782067874775122 0.00443725251526842 -1.16357283690918 1.63774086027679e-06 MirTarget -0.115568250605295 0.00948870207662742 NA NA NA hsa-miR-103a-3p PIK3R1 1.44083190496858 1.53799939616416e-13 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.175702483843164 0.00322284399016944 NA NA NA hsa-miR-106b-5p PIK3R1 2.46782146831112 1.36171495805632e-23 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.24930934707311 3.35624085651532e-08 NA NA NA hsa-miR-107 PIK3R1 1.30977326593435 1.30372468603965e-11 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.201353514049413 0.000854368494298006 NA NA NA hsa-miR-127-5p PIK3R1 1.19850695520181 4.10976607177645e-05 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.164276045731973 4.35688271416755e-05 24004856 Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR 127 in human bladder cancer; These findings provide new insights into the role of miRNAs in the pathway of cancer and give us a hypothesis that miR-127 might play a similar role in regulation and control of PIK3R1 bladder cancer hsa-miR-128-3p PIK3R1 1.63756041666078 6.79626586407187e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.134770050316621 0.0111594593028352 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 2.54959518791507 5.26618591274892e-18 -1.16357283690918 1.63774086027679e-06 MirTarget -0.146009716288673 0.000153002833756534 NA NA NA hsa-miR-132-3p PIK3R1 0.156276992635384 0.408190812100704 -1.16357283690918 1.63774086027679e-06 MirTarget -0.197496588157407 0.00191277589406782 NA NA NA hsa-miR-15a-5p PIK3R1 2.34669284378787 1.69544424500258e-23 -1.16357283690918 1.63774086027679e-06 MirTarget -0.142181030175195 0.00308171212654804 NA NA NA hsa-miR-15b-5p PIK3R1 1.57112623124278 9.14247846750597e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203388250610072 0.000112366544945594 NA NA NA hsa-miR-16-2-3p PIK3R1 2.31623086727196 4.29838149388188e-20 -1.16357283690918 1.63774086027679e-06 MirTarget -0.207543782293348 3.49270114018875e-06 NA NA NA hsa-miR-16-5p PIK3R1 1.75824877145857 1.68592440033108e-16 -1.16357283690918 1.63774086027679e-06 MirTarget -0.20266090985161 0.000166722510489398 NA NA NA hsa-miR-17-5p PIK3R1 3.2710598467455 9.93128340539455e-27 -1.16357283690918 1.63774086027679e-06 MirTarget;TargetScan;miRNATAP -0.194269031204595 7.03363082546611e-08 NA NA NA hsa-miR-185-5p PIK3R1 2.34016206907488 1.17481626642022e-26 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.305558512858305 1.29388513669652e-09 NA NA NA hsa-miR-186-5p PIK3R1 1.47445398888668 3.0781726595413e-15 -1.16357283690918 1.63774086027679e-06 mirMAP -0.274872917366815 8.27585129634137e-06 NA NA NA hsa-miR-188-5p PIK3R1 2.52825126596644 6.78099435999778e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.185661747772095 2.50402606338374e-07 NA NA NA hsa-miR-199a-3p PIK3R1 0.640600337515787 0.0380326905134914 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.156998919927599 4.11373421997523e-05 NA NA NA hsa-miR-199b-3p PIK3R1 0.643923492750702 0.0371742251925406 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.157124307871095 4.00275047495595e-05 NA NA NA hsa-miR-20a-5p PIK3R1 3.15577933619191 4.19753346442454e-25 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.184775072209508 3.70396511881761e-07 NA NA NA hsa-miR-21-5p PIK3R1 2.73773305747971 1.38864982139576e-43 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.344443286817705 1.08270725892964e-10 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.357878936470387 0.232446214501331 -1.16357283690918 1.63774086027679e-06 MirTarget -0.126995222417611 0.00147059810557586 NA NA NA hsa-miR-22-5p PIK3R1 1.88011544159252 1.63978222572222e-16 -1.16357283690918 1.63774086027679e-06 mirMAP -0.292552038138818 3.89552165607854e-09 NA NA NA hsa-miR-221-3p PIK3R1 0.451556679024397 0.0909808299917811 -1.16357283690918 1.63774086027679e-06 MirTarget -0.108240747635063 0.015387314456947 NA NA NA hsa-miR-222-3p PIK3R1 0.851783756239071 0.00266783568486918 -1.16357283690918 1.63774086027679e-06 MirTarget -0.122260306324505 0.00346350093932025 NA NA NA hsa-miR-29a-3p PIK3R1 -0.35074463683376 0.161238718982428 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.197768036084372 3.04095884680599e-05 NA NA NA hsa-miR-29b-3p PIK3R1 1.65828197923813 1.02676780888141e-09 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.226570180742736 9.59427672061032e-08 NA NA NA hsa-miR-3065-5p PIK3R1 2.74629919868982 1.86846589298284e-08 -1.16357283690918 1.63774086027679e-06 MirTarget;mirMAP;miRNATAP -0.121456370441073 3.04699134862982e-05 NA NA NA hsa-miR-369-3p PIK3R1 0.946781510019564 0.00134850306966842 -1.16357283690918 1.63774086027679e-06 PITA -0.165045838001649 3.68847028364345e-05 NA NA NA hsa-miR-409-3p PIK3R1 0.877551657794358 0.00171210686733898 -1.16357283690918 1.63774086027679e-06 mirMAP -0.105859697586648 0.0126015776971144 NA NA NA hsa-miR-424-5p PIK3R1 1.61930224569578 1.89642549274994e-10 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203727044936863 7.79524954848401e-06 NA NA NA hsa-miR-450b-5p PIK3R1 1.69244418548325 1.68064054148881e-10 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.119371689321084 0.0066882062526509 NA NA NA hsa-miR-455-3p PIK3R1 3.06093594997644 3.54590649799868e-16 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.151223028806072 5.34851043578223e-07 NA NA NA hsa-miR-485-3p PIK3R1 0.442820096243914 0.166634696770945 -1.16357283690918 1.63774086027679e-06 mirMAP -0.104228852223792 0.00542492277409986 NA NA NA hsa-miR-493-5p PIK3R1 0.847772103665986 0.00528678068747754 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.141629319654 0.000286613564823519 NA NA NA hsa-miR-532-3p PIK3R1 1.96631878320218 4.53421954361695e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.183574493282594 1.45132602336302e-05 NA NA NA hsa-miR-584-5p PIK3R1 2.7326672683732 9.92677936962233e-12 -1.16357283690918 1.63774086027679e-06 mirMAP -0.136506526285572 1.76178566940588e-06 NA NA NA hsa-miR-589-3p PIK3R1 2.51971841868825 2.39125940264107e-11 -1.16357283690918 1.63774086027679e-06 mirMAP -0.146863008859422 2.43953052082368e-05 NA NA NA hsa-miR-590-3p PIK3R1 2.59289455139753 1.03200520972022e-21 -1.16357283690918 1.63774086027679e-06 miRanda;mirMAP -0.251414695908109 2.6774008322444e-09 NA NA NA hsa-miR-590-5p PIK3R1 3.18300989862077 2.06813568597893e-26 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.233958943001206 5.13569363038349e-10 NA NA NA hsa-miR-629-3p PIK3R1 2.36570947321815 1.33458201201618e-11 -1.16357283690918 1.63774086027679e-06 MirTarget -0.157530213698435 2.37486100403133e-05 NA NA NA hsa-miR-93-5p PIK3R1 3.03961860136032 1.11672209617395e-24 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.155676924698248 3.5347453293642e-05 NA NA NA hsa-miR-96-5p PIK3R1 4.89433085814374 1.92000659886961e-31 -1.16357283690918 1.63774086027679e-06 TargetScan;miRNATAP -0.102966561567807 0.000122371084822612 NA NA NA hsa-miR-1271-5p PIK3R3 0.970418832993172 0.000609742584380688 -0.627704444396048 0.00578594022892978 mirMAP -0.151257171385516 9.56593049733625e-05 NA NA NA hsa-miR-181a-5p PIK3R3 2.29556023480783 1.8138457900616e-21 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.108906602043709 0.0127134423930606 NA NA NA hsa-miR-18a-3p PIK3R3 2.14813400940323 2.23460809936028e-06 -0.627704444396048 0.00578594022892978 miRNAWalker2_validate -0.10342220794232 0.000634896497880219 NA NA NA hsa-miR-19a-3p PIK3R3 3.42309334186656 3.02671914353412e-28 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.120784849374387 0.0002630092907536 NA NA NA hsa-miR-19b-3p PIK3R3 2.49529833021187 1.57028265846699e-23 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.146052627292238 0.000482454548266062 NA NA NA hsa-miR-222-5p PIK3R3 1.25632771414778 0.000138653440511922 -0.627704444396048 0.00578594022892978 mirMAP -0.146201383530692 9.47483044017924e-06 NA NA NA hsa-miR-26b-5p PIK3R3 0.885393662798425 3.2116297961629e-06 -0.627704444396048 0.00578594022892978 miRNATAP -0.184498425433638 0.00145436639404193 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.55384379072167 4.76870585070176e-05 -0.627704444396048 0.00578594022892978 mirMAP -0.182944374912975 8.7655907053222e-10 NA NA NA hsa-miR-365a-3p PIK3R3 -0.0388985816963467 0.859114494267351 -0.627704444396048 0.00578594022892978 MirTarget -0.222976439335601 9.85809729911043e-06 NA NA NA hsa-miR-511-5p PIK3R3 1.04499312543772 0.00234126154508174 -0.627704444396048 0.00578594022892978 MirTarget -0.132527709680848 3.18921565069019e-05 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-92a-3p PIK3R3 2.06460102658973 1.44784291084757e-19 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.185970971603602 5.73870254874264e-05 NA NA NA hsa-miR-107 PIK3R5 1.30977326593435 1.30372468603965e-11 -0.990769658200862 0.00792713202187119 miRanda -0.533513362792699 4.18278914923372e-09 NA NA NA hsa-miR-125a-3p PIK3R5 1.24490295132072 5.26925231010328e-06 -0.990769658200862 0.00792713202187119 miRanda -0.135508023882326 0.0399369211652034 NA NA NA hsa-miR-125a-5p PIK3R5 0.599529391575274 0.0102300147180307 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.398754902125041 2.22481895610409e-07 NA NA NA hsa-miR-182-5p PIK3R5 3.53923166221814 5.07781258121574e-21 -0.990769658200862 0.00792713202187119 MirTarget -0.391730270801049 4.50362857100536e-19 NA NA NA hsa-miR-185-5p PIK3R5 2.34016206907488 1.17481626642022e-26 -0.990769658200862 0.00792713202187119 MirTarget -0.277336834855249 0.000367374066791577 NA NA NA hsa-miR-18a-3p PIK3R5 2.14813400940323 2.23460809936028e-06 -0.990769658200862 0.00792713202187119 MirTarget -0.132688083528877 0.0077571943603639 NA NA NA hsa-miR-330-5p PIK3R5 1.15100069700871 4.85551805046014e-07 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.220865262481851 0.00496435762424894 NA NA NA hsa-miR-944 PIK3R5 2.91186649218281 1.31574753528144e-06 -0.990769658200862 0.00792713202187119 mirMAP -0.201291119960673 1.82909637448261e-11 NA NA NA hsa-miR-149-5p PIK3R6 2.94200492826326 4.93436498919036e-14 -0.682202745051388 0.0458145956987097 MirTarget -0.284835572881355 1.06913642650233e-12 NA NA NA hsa-miR-26b-5p PKN1 0.885393662798425 3.2116297961629e-06 -0.276260688686055 0.250693746786265 miRNAWalker2_validate -0.195696753006895 0.00134952249375083 NA NA NA hsa-let-7i-5p PKN2 0.412877696970403 0.00622731051981756 -0.125971889563031 0.414793940700722 miRNATAP -0.214628215817551 1.73140340707886e-05 NA NA NA hsa-miR-155-5p PKN2 1.20164021433135 0.00086170622431261 -0.125971889563031 0.414793940700722 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.111471465802844 3.79566738378642e-08 NA NA NA hsa-miR-199a-5p PKN2 0.592984035153911 0.0674836634175293 -0.125971889563031 0.414793940700722 miRNATAP -0.147208996973533 6.01687242215857e-11 NA NA NA hsa-miR-218-5p PKN2 -0.573801507392184 0.0551983860126703 -0.125971889563031 0.414793940700722 MirTarget -0.126249471000498 2.98391879433886e-07 NA NA NA hsa-miR-183-5p PPP2CB 4.19757025992371 4.79612296318304e-26 -0.783679156108793 2.67817932533534e-08 MirTarget;miRNATAP -0.115935862473986 2.8039910681077e-13 NA NA NA hsa-miR-32-3p PPP2CB 2.02436999565685 5.94091197945307e-09 -0.783679156108793 2.67817932533534e-08 MirTarget -0.105750464768045 1.64351977471817e-06 NA NA NA hsa-miR-361-5p PPP2CB 0.971859117235239 5.30236555707088e-09 -0.783679156108793 2.67817932533534e-08 miRanda -0.206656922572491 4.60021445788998e-07 NA NA NA hsa-miR-425-5p PPP2CB 3.07071373939774 4.02947460586085e-25 -0.783679156108793 2.67817932533534e-08 miRNAWalker2_validate -0.185494581813071 1.46832581012673e-18 NA NA NA hsa-let-7d-5p PPP2R2A 1.33236798905207 1.1741085658466e-13 -0.403063589569943 0.0064064984207387 miRNATAP -0.135297179368885 0.000528587919196092 NA NA NA hsa-miR-140-3p PPP2R2A 0.0608890720479334 0.727716871248724 -0.403063589569943 0.0064064984207387 PITA -0.102952686199167 0.0133535907064303 NA NA NA hsa-miR-450b-5p PPP2R2A 1.69244418548325 1.68064054148881e-10 -0.403063589569943 0.0064064984207387 PITA;mirMAP -0.106495945788614 5.33666403736845e-05 NA NA NA hsa-miR-126-5p PPP2R2B 0.895338176458417 2.33372756450713e-05 -2.25289619507804 0.000180435522352838 MirTarget -0.383045353036009 0.00567656859840651 NA NA NA hsa-miR-495-3p PPP2R2B -0.0847115949846082 0.763475496144456 -2.25289619507804 0.000180435522352838 mirMAP -0.213579320464633 0.0421308769086957 NA NA NA hsa-miR-496 PPP2R2B 0.46914638405371 0.145980484291736 -2.25289619507804 0.000180435522352838 miRanda -0.371263243837406 6.11288048587766e-05 NA NA NA hsa-miR-7-1-3p PPP2R2B 1.84950311431067 1.25300363397654e-13 -2.25289619507804 0.000180435522352838 mirMAP -0.513497586532207 6.22874268961141e-06 NA NA NA hsa-miR-125a-3p PPP2R2C 1.24490295132072 5.26925231010328e-06 -0.795459846555288 0.266159255773917 miRanda -0.490921209474882 8.8742252357981e-05 NA NA NA hsa-miR-148b-5p PPP2R2C 2.18024067300781 2.84770452413262e-14 -0.795459846555288 0.266159255773917 mirMAP -0.480420136087959 9.92487765697059e-05 NA NA NA hsa-miR-181a-2-3p PPP2R2C 2.19062681262366 3.81790102612782e-13 -0.795459846555288 0.266159255773917 MirTarget -0.448111912961894 5.46490075193365e-05 NA NA NA hsa-miR-181b-5p PPP2R2C 2.49307679431293 3.92829250217627e-20 -0.795459846555288 0.266159255773917 mirMAP -0.485726885522172 6.359913390984e-05 NA NA NA hsa-miR-192-5p PPP2R2C 2.69002528723195 1.22990188194432e-16 -0.795459846555288 0.266159255773917 mirMAP -0.224721704438767 0.0288143456493046 NA NA NA hsa-miR-194-5p PPP2R2C 1.8992998339217 3.76507853301977e-10 -0.795459846555288 0.266159255773917 miRNATAP -0.360529551006111 0.00125231259350066 NA NA NA hsa-miR-200b-3p PPP2R2C 3.78235093249346 3.18343003239465e-14 -0.795459846555288 0.266159255773917 TargetScan -0.307390894454467 3.90674354552055e-06 NA NA NA hsa-miR-200c-3p PPP2R2C 3.50132673580082 2.42716349086937e-15 -0.795459846555288 0.266159255773917 miRNATAP -0.306291787073106 4.49365552911052e-05 NA NA NA hsa-miR-320a PPP2R2C 0.438165828017084 0.0390159073347133 -0.795459846555288 0.266159255773917 MirTarget;PITA;miRanda;miRNATAP -0.676342096282759 3.47297419282436e-05 NA NA NA hsa-miR-320b PPP2R2C 1.55692969039548 1.41071034251915e-08 -0.795459846555288 0.266159255773917 MirTarget;PITA;miRanda;miRNATAP -0.249191637785433 0.0454841737368944 NA NA NA hsa-miR-339-5p PPP2R2C 2.68710938429893 3.03134080808154e-16 -0.795459846555288 0.266159255773917 miRanda -0.288702394532432 0.00443412645568505 NA NA NA hsa-miR-429 PPP2R2C 4.48815175680773 2.44117492218206e-17 -0.795459846555288 0.266159255773917 PITA;miRanda;miRNATAP -0.269422401877531 1.4787975278128e-05 NA NA NA hsa-miR-500a-3p PPP2R2C 1.47161373123699 5.30571342631915e-09 -0.795459846555288 0.266159255773917 MirTarget -0.382661637452168 0.00470212406471155 NA NA NA hsa-miR-501-3p PPP2R2C 1.83132758513743 1.10971547702065e-10 -0.795459846555288 0.266159255773917 MirTarget;PITA;TargetScan;miRNATAP -0.398000149688683 0.000844564732429004 NA NA NA hsa-miR-502-3p PPP2R2C 1.50560877085049 1.2647489756373e-11 -0.795459846555288 0.266159255773917 MirTarget;PITA;miRNATAP -0.546851224300787 0.000333321417808122 NA NA NA hsa-miR-542-3p PPP2R2C 1.18832665895751 1.98700670691565e-07 -0.795459846555288 0.266159255773917 miRanda -0.332352966253798 0.0272740720712224 NA NA NA hsa-miR-106b-5p PPP2R3A 2.46782146831112 1.36171495805632e-23 -0.635587926025165 0.0133804555089022 mirMAP -0.262119231416352 3.05246524939681e-08 NA NA NA hsa-miR-125a-5p PPP2R3A 0.599529391575274 0.0102300147180307 -0.635587926025165 0.0133804555089022 miRanda -0.305968434195442 6.56251501119964e-09 NA NA NA hsa-miR-128-3p PPP2R3A 1.63756041666078 6.79626586407187e-14 -0.635587926025165 0.0133804555089022 MirTarget -0.131824112981737 0.0179536144679559 NA NA NA hsa-miR-140-5p PPP2R3A 0.844753502512594 3.73722278438606e-05 -0.635587926025165 0.0133804555089022 PITA;miRanda;miRNATAP -0.162907187902368 0.00743582059722901 NA NA NA hsa-miR-148b-3p PPP2R3A 1.97815018171325 6.07715327281595e-26 -0.635587926025165 0.0133804555089022 miRNAWalker2_validate -0.356535742439653 9.15337850851577e-09 NA NA NA hsa-miR-17-5p PPP2R3A 3.2710598467455 9.93128340539455e-27 -0.635587926025165 0.0133804555089022 mirMAP -0.130667073509948 0.000618645860536964 NA NA NA hsa-miR-181a-5p PPP2R3A 2.29556023480783 1.8138457900616e-21 -0.635587926025165 0.0133804555089022 MirTarget -0.214979024672643 1.13491126749222e-05 NA NA NA hsa-miR-181b-5p PPP2R3A 2.49307679431293 3.92829250217627e-20 -0.635587926025165 0.0133804555089022 MirTarget -0.137982088089474 0.00165558944655206 NA NA NA hsa-miR-181c-5p PPP2R3A 1.58587920618301 1.57506918816933e-10 -0.635587926025165 0.0133804555089022 MirTarget -0.245510765866136 5.0317705195835e-07 NA NA NA hsa-miR-181d-5p PPP2R3A 1.52204912185579 9.2693319057748e-08 -0.635587926025165 0.0133804555089022 MirTarget -0.163687681796737 0.000142222966278517 NA NA NA hsa-miR-186-5p PPP2R3A 1.47445398888668 3.0781726595413e-15 -0.635587926025165 0.0133804555089022 MirTarget;mirMAP -0.215360977768057 0.000918745416058224 NA NA NA hsa-miR-20a-5p PPP2R3A 3.15577933619191 4.19753346442454e-25 -0.635587926025165 0.0133804555089022 mirMAP -0.161528602146652 2.45266152385082e-05 NA NA NA hsa-miR-26b-5p PPP2R3A 0.885393662798425 3.2116297961629e-06 -0.635587926025165 0.0133804555089022 miRNATAP -0.237795678700797 0.000271873877348194 NA NA NA hsa-miR-30b-3p PPP2R3A 0.834142820354026 0.000972582820878813 -0.635587926025165 0.0133804555089022 MirTarget -0.138665981350954 0.00506090873665954 NA NA NA hsa-miR-320a PPP2R3A 0.438165828017084 0.0390159073347133 -0.635587926025165 0.0133804555089022 miRanda -0.37619280380405 8.33138537950878e-11 NA NA NA hsa-miR-320b PPP2R3A 1.55692969039548 1.41071034251915e-08 -0.635587926025165 0.0133804555089022 miRanda -0.17095603950003 0.000124097414637097 NA NA NA hsa-miR-34a-5p PPP2R3A 1.9016323452565 1.43092834643601e-14 -0.635587926025165 0.0133804555089022 MirTarget;miRNATAP -0.336602423463064 1.88624747596278e-12 NA NA NA hsa-miR-409-5p PPP2R3A 1.56949123847358 5.91654175754272e-07 -0.635587926025165 0.0133804555089022 miRNATAP -0.129638641218032 0.00175042786952387 NA NA NA hsa-miR-429 PPP2R3A 4.48815175680773 2.44117492218206e-17 -0.635587926025165 0.0133804555089022 miRanda -0.154709882463775 1.93798133472064e-12 NA NA NA hsa-miR-576-5p PPP2R3A 2.20467023993664 3.4053475193793e-19 -0.635587926025165 0.0133804555089022 PITA;mirMAP -0.139827408281579 0.00399122097215849 NA NA NA hsa-miR-590-3p PPP2R3A 2.59289455139753 1.03200520972022e-21 -0.635587926025165 0.0133804555089022 MirTarget;PITA;miRanda -0.11659158913662 0.00965141262623685 NA NA NA hsa-miR-93-5p PPP2R3A 3.03961860136032 1.11672209617395e-24 -0.635587926025165 0.0133804555089022 mirMAP -0.248946151258044 1.57718959397895e-10 NA NA NA hsa-miR-103a-3p PPP2R3C 1.44083190496858 1.53799939616416e-13 -0.549333967996778 6.65785633976014e-06 MirTarget -0.138814796179463 2.64375971218437e-06 NA NA NA hsa-miR-107 PPP2R3C 1.30977326593435 1.30372468603965e-11 -0.549333967996778 6.65785633976014e-06 MirTarget;miRanda;miRNATAP -0.14586838271962 1.09894076735068e-06 NA NA NA hsa-miR-361-5p PPP2R3C 0.971859117235239 5.30236555707088e-09 -0.549333967996778 6.65785633976014e-06 miRanda -0.199653998410707 1.2262336392092e-08 NA NA NA hsa-miR-107 PPP2R5A 1.30977326593435 1.30372468603965e-11 -0.903448375131664 8.39328972558812e-12 miRanda -0.224947751657196 4.70987626884361e-12 NA NA NA hsa-miR-197-3p PPP2R5A 1.75733174019505 8.88576793100499e-13 -0.903448375131664 8.39328972558812e-12 MirTarget -0.168187304798222 3.80039885887156e-11 NA NA NA hsa-miR-34a-5p PPP2R5A 1.9016323452565 1.43092834643601e-14 -0.903448375131664 8.39328972558812e-12 MirTarget;miRNATAP -0.101688531317395 7.12383430257492e-05 NA NA NA hsa-miR-455-5p PPP2R5A 2.2582442061694 1.43472128037398e-13 -0.903448375131664 8.39328972558812e-12 miRanda -0.109914486969236 8.84512455058286e-08 NA NA NA hsa-miR-484 PPP2R5A 1.81844463411787 1.82951571230938e-15 -0.903448375131664 8.39328972558812e-12 miRNAWalker2_validate -0.16770839153884 8.04350521732411e-10 NA NA NA hsa-miR-590-3p PPP2R5A 2.59289455139753 1.03200520972022e-21 -0.903448375131664 8.39328972558812e-12 miRNAWalker2_validate -0.153925977316081 2.89830567232078e-11 NA NA NA hsa-miR-744-5p PPP2R5B 1.48254348878737 3.23019501613577e-09 -0.31859896881852 0.0287055664679159 MirTarget -0.11714720009535 2.06087544503158e-05 NA NA NA hsa-miR-125a-5p PPP2R5C 0.599529391575274 0.0102300147180307 -0.521480329500893 1.91945462921615e-07 MirTarget;PITA;miRanda -0.115314852256606 2.48746606736075e-08 NA NA NA hsa-miR-140-3p PPP2R5C 0.0608890720479334 0.727716871248724 -0.521480329500893 1.91945462921615e-07 MirTarget -0.112361878880438 6.83972421205159e-05 NA NA NA hsa-miR-186-5p PPP2R5C 1.47445398888668 3.0781726595413e-15 -0.521480329500893 1.91945462921615e-07 mirMAP;miRNATAP -0.138496919779324 3.715710908355e-08 NA NA NA hsa-miR-101-5p PPP2R5E 0.782067874775122 0.00443725251526842 -0.277275686002286 0.0553819870972808 MirTarget -0.127293557994918 9.10136825621678e-07 NA NA NA hsa-miR-125a-5p PPP2R5E 0.599529391575274 0.0102300147180307 -0.277275686002286 0.0553819870972808 miRNAWalker2_validate -0.203094773845661 4.35836001954904e-12 NA NA NA hsa-miR-181a-5p PPP2R5E 2.29556023480783 1.8138457900616e-21 -0.277275686002286 0.0553819870972808 MirTarget;mirMAP -0.134280374282853 9.42260409675176e-07 NA NA NA hsa-miR-181c-5p PPP2R5E 1.58587920618301 1.57506918816933e-10 -0.277275686002286 0.0553819870972808 MirTarget;mirMAP -0.135897759869079 7.11089574419858e-07 NA NA NA hsa-miR-29b-2-5p PPP2R5E 0.910668640983475 0.00666655585493488 -0.277275686002286 0.0553819870972808 mirMAP -0.120756928794226 3.55710707680044e-09 NA NA NA hsa-miR-30a-5p PPP2R5E -0.878357906436456 0.000509952992366057 -0.277275686002286 0.0553819870972808 mirMAP -0.111175309666902 5.16408706706393e-05 NA NA NA hsa-miR-30b-5p PPP2R5E 0.800822374912712 0.000133601914525413 -0.277275686002286 0.0553819870972808 mirMAP -0.100564762573576 0.00255890060927322 NA NA NA hsa-miR-30c-5p PPP2R5E 0.778774633108 0.000285599212429136 -0.277275686002286 0.0553819870972808 mirMAP -0.196572491249197 8.38970528577029e-10 NA NA NA hsa-miR-30e-5p PPP2R5E 1.23904909539663 1.35561917122157e-09 -0.277275686002286 0.0553819870972808 mirMAP -0.152449869597762 5.47961799645938e-06 NA NA NA hsa-let-7a-3p PRKAA2 1.42015538786275 7.03375209382654e-13 -3.1651157275578 4.06046613880045e-09 mirMAP -0.368546290584595 0.00514409913387135 NA NA NA hsa-let-7b-3p PRKAA2 0.868207752019623 1.30460056774366e-05 -3.1651157275578 4.06046613880045e-09 mirMAP -0.262674016711226 0.0494116538292108 NA NA NA hsa-let-7d-5p PRKAA2 1.33236798905207 1.1741085658466e-13 -3.1651157275578 4.06046613880045e-09 MirTarget -0.722750408548456 4.99138878435736e-07 NA NA NA hsa-let-7f-1-3p PRKAA2 1.55054488387679 7.31326775537952e-11 -3.1651157275578 4.06046613880045e-09 mirMAP -0.46638995733722 3.18954726371122e-05 NA NA NA hsa-let-7f-5p PRKAA2 0.495648727272215 0.00355972741198794 -3.1651157275578 4.06046613880045e-09 MirTarget -0.311815532548627 0.0490723533883445 NA NA NA hsa-let-7g-5p PRKAA2 1.20061455355116 1.50237505511483e-12 -3.1651157275578 4.06046613880045e-09 MirTarget -0.829014454032662 5.47891741707445e-08 NA NA NA hsa-let-7i-5p PRKAA2 0.412877696970403 0.00622731051981756 -3.1651157275578 4.06046613880045e-09 MirTarget -0.607502181924338 0.000681606877218508 NA NA NA hsa-miR-103a-2-5p PRKAA2 2.47599305985086 7.933028987326e-11 -3.1651157275578 4.06046613880045e-09 mirMAP -0.273304170202619 0.000379680069074106 NA NA NA hsa-miR-106b-5p PRKAA2 2.46782146831112 1.36171495805632e-23 -3.1651157275578 4.06046613880045e-09 mirMAP -0.449758621112524 9.45695175297387e-06 NA NA NA hsa-miR-125a-5p PRKAA2 0.599529391575274 0.0102300147180307 -3.1651157275578 4.06046613880045e-09 PITA -0.365087293868699 0.00135901058962619 NA NA NA hsa-miR-126-5p PRKAA2 0.895338176458417 2.33372756450713e-05 -3.1651157275578 4.06046613880045e-09 mirMAP -0.499415855416577 6.2491772215473e-05 NA NA NA hsa-miR-130b-3p PRKAA2 3.5350292994509 1.73934183852569e-27 -3.1651157275578 4.06046613880045e-09 MirTarget -0.30993060839259 4.53844629194696e-05 NA NA NA hsa-miR-141-3p PRKAA2 5.02396127982626 2.19224509139725e-24 -3.1651157275578 4.06046613880045e-09 mirMAP -0.311674641790567 3.76173236669185e-10 NA NA NA hsa-miR-142-5p PRKAA2 1.17581605694506 0.0018174701991234 -3.1651157275578 4.06046613880045e-09 mirMAP -0.307256732153854 1.00914367535293e-05 NA NA NA hsa-miR-146a-5p PRKAA2 1.19829319599115 0.00157081974524452 -3.1651157275578 4.06046613880045e-09 MirTarget -0.298359820970352 1.6416322978257e-05 NA NA NA hsa-miR-146b-5p PRKAA2 1.75587235896724 1.15724631266659e-07 -3.1651157275578 4.06046613880045e-09 MirTarget -0.311641849597315 7.38240690301751e-05 NA NA NA hsa-miR-15b-3p PRKAA2 2.33847028227712 4.29662877950836e-19 -3.1651157275578 4.06046613880045e-09 mirMAP -0.477684703528837 7.08126425805273e-07 NA NA NA hsa-miR-16-2-3p PRKAA2 2.31623086727196 4.29838149388188e-20 -3.1651157275578 4.06046613880045e-09 mirMAP -0.627940578646649 2.13766832392934e-10 NA NA NA hsa-miR-17-5p PRKAA2 3.2710598467455 9.93128340539455e-27 -3.1651157275578 4.06046613880045e-09 mirMAP -0.365611825057462 6.28601305540822e-06 NA NA NA hsa-miR-181a-2-3p PRKAA2 2.19062681262366 3.81790102612782e-13 -3.1651157275578 4.06046613880045e-09 mirMAP -0.446762077174767 1.28755345125413e-07 NA NA NA hsa-miR-181a-5p PRKAA2 2.29556023480783 1.8138457900616e-21 -3.1651157275578 4.06046613880045e-09 mirMAP -0.652763486781636 2.45814293770857e-10 NA NA NA hsa-miR-181b-5p PRKAA2 2.49307679431293 3.92829250217627e-20 -3.1651157275578 4.06046613880045e-09 mirMAP -0.553820083358037 1.79038809431955e-09 NA NA NA hsa-miR-182-5p PRKAA2 3.53923166221814 5.07781258121574e-21 -3.1651157275578 4.06046613880045e-09 miRNAWalker2_validate;MirTarget;mirMAP -0.331706760870251 5.94483360132956e-07 NA NA NA hsa-miR-186-5p PRKAA2 1.47445398888668 3.0781726595413e-15 -3.1651157275578 4.06046613880045e-09 MirTarget -0.526806950486461 0.000138268992490229 NA NA NA hsa-miR-192-5p PRKAA2 2.69002528723195 1.22990188194432e-16 -3.1651157275578 4.06046613880045e-09 miRNAWalker2_validate -0.161378715666907 0.0407539432354523 NA NA NA hsa-miR-19a-3p PRKAA2 3.42309334186656 3.02671914353412e-28 -3.1651157275578 4.06046613880045e-09 mirMAP -0.379428611341206 1.66931323472125e-06 NA NA NA hsa-miR-19b-3p PRKAA2 2.49529833021187 1.57028265846699e-23 -3.1651157275578 4.06046613880045e-09 mirMAP -0.447494148517396 8.06927629243583e-06 NA NA NA hsa-miR-200a-3p PRKAA2 4.59434485520731 6.38952518573476e-18 -3.1651157275578 4.06046613880045e-09 mirMAP -0.252415609716866 8.38336062600942e-08 NA NA NA hsa-miR-200b-3p PRKAA2 3.78235093249346 3.18343003239465e-14 -3.1651157275578 4.06046613880045e-09 MirTarget -0.261801092835381 2.7256487514151e-07 NA NA NA hsa-miR-200c-3p PRKAA2 3.50132673580082 2.42716349086937e-15 -3.1651157275578 4.06046613880045e-09 MirTarget -0.3165574137351 2.9537182424848e-08 NA NA NA hsa-miR-203a-3p PRKAA2 3.12352008343999 9.49391438647189e-07 -3.1651157275578 4.06046613880045e-09 MirTarget -0.114021445045374 0.00543014379350566 NA NA NA hsa-miR-20a-5p PRKAA2 3.15577933619191 4.19753346442454e-25 -3.1651157275578 4.06046613880045e-09 mirMAP -0.371335239957246 5.16233816597501e-06 NA NA NA hsa-miR-21-3p PRKAA2 2.19296355304364 4.63665722759779e-15 -3.1651157275578 4.06046613880045e-09 mirMAP -0.424686931257561 3.18678833497258e-06 NA NA NA hsa-miR-22-5p PRKAA2 1.88011544159252 1.63978222572222e-16 -3.1651157275578 4.06046613880045e-09 mirMAP -0.640613793079929 8.15181736251034e-09 NA NA NA hsa-miR-23a-3p PRKAA2 1.00493340843378 2.55313889288924e-08 -3.1651157275578 4.06046613880045e-09 mirMAP -0.717245625409375 7.83285299814301e-07 NA NA NA hsa-miR-26a-2-3p PRKAA2 0.823520019989974 0.00017092160823769 -3.1651157275578 4.06046613880045e-09 mirMAP -0.408717713181205 0.000788807753650383 NA NA NA hsa-miR-26a-5p PRKAA2 0.0464832722967259 0.752628386912329 -3.1651157275578 4.06046613880045e-09 mirMAP -0.397860835240243 0.0313650980967207 NA NA NA hsa-miR-26b-5p PRKAA2 0.885393662798425 3.2116297961629e-06 -3.1651157275578 4.06046613880045e-09 mirMAP -0.764962785810813 2.83597630191631e-08 NA NA NA hsa-miR-27b-5p PRKAA2 0.393316367667332 0.051702301924024 -3.1651157275578 4.06046613880045e-09 MirTarget;miRNATAP -0.383639737600614 0.0037825291986155 NA NA NA hsa-miR-29b-2-5p PRKAA2 0.910668640983475 0.00666655585493488 -3.1651157275578 4.06046613880045e-09 mirMAP -0.279808749959182 0.00038252900575232 NA NA NA hsa-miR-301a-3p PRKAA2 2.81024345929638 2.29784847962242e-17 -3.1651157275578 4.06046613880045e-09 MirTarget -0.231119799911066 0.0045176787682093 NA NA NA hsa-miR-30b-5p PRKAA2 0.800822374912712 0.000133601914525413 -3.1651157275578 4.06046613880045e-09 MirTarget -0.288057119153475 0.0233572155059335 NA NA NA hsa-miR-30c-5p PRKAA2 0.778774633108 0.000285599212429136 -3.1651157275578 4.06046613880045e-09 MirTarget -0.356922096763827 0.00395922355020181 NA NA NA hsa-miR-30d-3p PRKAA2 0.977747550180601 4.3048212205381e-05 -3.1651157275578 4.06046613880045e-09 MirTarget;miRNATAP -0.240071186464927 0.0307082267542837 NA NA NA hsa-miR-30d-5p PRKAA2 0.675423997639582 0.00270618816039773 -3.1651157275578 4.06046613880045e-09 MirTarget -0.271897797341097 0.0216937703176945 NA NA NA hsa-miR-30e-5p PRKAA2 1.23904909539663 1.35561917122157e-09 -3.1651157275578 4.06046613880045e-09 MirTarget -0.575531898888406 6.37486734638196e-06 NA NA NA hsa-miR-31-5p PRKAA2 3.59165123035072 2.27423212057482e-07 -3.1651157275578 4.06046613880045e-09 MirTarget -0.151730039535611 0.000135936484549104 NA NA NA hsa-miR-32-3p PRKAA2 2.02436999565685 5.94091197945307e-09 -3.1651157275578 4.06046613880045e-09 MirTarget -0.205177944089292 0.0165918636397811 NA NA NA hsa-miR-330-3p PRKAA2 0.876747334239085 0.00073709016089703 -3.1651157275578 4.06046613880045e-09 MirTarget -0.286102780581204 0.00506815071493037 NA NA NA hsa-miR-331-3p PRKAA2 2.28379581858927 1.99663919173155e-18 -3.1651157275578 4.06046613880045e-09 MirTarget -0.364561950555569 0.000185201672784168 NA NA NA hsa-miR-335-3p PRKAA2 3.08791651139852 5.31309869723517e-12 -3.1651157275578 4.06046613880045e-09 MirTarget -0.217607069917347 0.000151452265177902 NA NA NA hsa-miR-335-5p PRKAA2 1.77247705492746 2.22457658872091e-06 -3.1651157275578 4.06046613880045e-09 MirTarget;miRNATAP -0.189757321047362 0.00673896582128403 NA NA NA hsa-miR-33a-3p PRKAA2 1.72765312072219 1.51784443453521e-07 -3.1651157275578 4.06046613880045e-09 mirMAP -0.197716151311991 0.0240888641750769 NA NA NA hsa-miR-342-3p PRKAA2 1.49115144672245 1.43879249744621e-07 -3.1651157275578 4.06046613880045e-09 PITA -0.365301673219482 7.27987168209179e-05 NA NA NA hsa-miR-34a-5p PRKAA2 1.9016323452565 1.43092834643601e-14 -3.1651157275578 4.06046613880045e-09 miRNATAP -0.697992393841294 7.93258270698692e-12 NA NA NA hsa-miR-374a-3p PRKAA2 0.533309330504947 0.00192918429705142 -3.1651157275578 4.06046613880045e-09 mirMAP -0.468265324710388 0.0026860278599259 NA NA NA hsa-miR-429 PRKAA2 4.48815175680773 2.44117492218206e-17 -3.1651157275578 4.06046613880045e-09 MirTarget;miRNATAP -0.234368381119893 8.26598458529829e-07 NA NA NA hsa-miR-454-3p PRKAA2 2.47234127820054 1.12878018736016e-21 -3.1651157275578 4.06046613880045e-09 MirTarget -0.516124002344748 2.14118798191959e-07 NA NA NA hsa-miR-500a-5p PRKAA2 1.72110365584658 3.0807246212659e-10 -3.1651157275578 4.06046613880045e-09 mirMAP -0.291639409971857 0.00221883780805263 NA NA NA hsa-miR-576-5p PRKAA2 2.20467023993664 3.4053475193793e-19 -3.1651157275578 4.06046613880045e-09 mirMAP -0.576206223473929 1.6711936398277e-08 NA NA NA hsa-miR-582-5p PRKAA2 0.609226359812689 0.032988717891497 -3.1651157275578 4.06046613880045e-09 mirMAP -0.270459108094453 0.00363606827304358 NA NA NA hsa-miR-589-5p PRKAA2 1.71990116752371 8.310889042056e-14 -3.1651157275578 4.06046613880045e-09 MirTarget -0.376078241087496 0.00080032835281227 NA NA NA hsa-miR-590-3p PRKAA2 2.59289455139753 1.03200520972022e-21 -3.1651157275578 4.06046613880045e-09 mirMAP;miRNATAP -0.430999919941564 6.04499840743536e-06 NA NA NA hsa-miR-664a-3p PRKAA2 0.634721925861133 0.00520070178640421 -3.1651157275578 4.06046613880045e-09 MirTarget -0.510084786462165 1.19979296115228e-05 NA NA NA hsa-miR-7-1-3p PRKAA2 1.84950311431067 1.25300363397654e-13 -3.1651157275578 4.06046613880045e-09 MirTarget;mirMAP -0.360511833799086 0.000488208563484811 NA NA NA hsa-miR-93-5p PRKAA2 3.03961860136032 1.11672209617395e-24 -3.1651157275578 4.06046613880045e-09 mirMAP -0.360317996321163 1.81157969199634e-05 NA NA NA hsa-miR-944 PRKAA2 2.91186649218281 1.31574753528144e-06 -3.1651157275578 4.06046613880045e-09 mirMAP -0.304599294327695 3.71005202161829e-12 NA NA NA hsa-miR-96-5p PRKAA2 4.89433085814374 1.92000659886961e-31 -3.1651157275578 4.06046613880045e-09 TargetScan -0.301126902372243 4.20848274807667e-07 NA NA NA hsa-miR-98-5p PRKAA2 1.11154309866014 1.24143909012085e-08 -3.1651157275578 4.06046613880045e-09 miRNAWalker2_validate;MirTarget -0.364025165304353 0.00705071490635534 NA NA NA hsa-miR-103a-2-5p PRKCA 2.47599305985086 7.933028987326e-11 -1.04253532292201 0.000330447904822586 mirMAP -0.10172330584904 0.0133291324421933 NA NA NA hsa-miR-142-5p PRKCA 1.17581605694506 0.0018174701991234 -1.04253532292201 0.000330447904822586 mirMAP -0.155281859758494 2.83714874751982e-05 NA NA NA hsa-miR-146a-5p PRKCA 1.19829319599115 0.00157081974524452 -1.04253532292201 0.000330447904822586 mirMAP -0.131710886401928 0.000370553312736514 NA NA NA hsa-miR-146b-5p PRKCA 1.75587235896724 1.15724631266659e-07 -1.04253532292201 0.000330447904822586 mirMAP -0.178218054737334 2.01234944480139e-05 NA NA NA hsa-miR-150-5p PRKCA -0.105827294491332 0.799351458244375 -1.04253532292201 0.000330447904822586 mirMAP -0.124697814540873 0.00022848052592286 NA NA NA hsa-miR-17-3p PRKCA 2.2704817679209 1.1667437320211e-22 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.163389027302081 0.00492702694664717 NA NA NA hsa-miR-181a-5p PRKCA 2.29556023480783 1.8138457900616e-21 -1.04253532292201 0.000330447904822586 mirMAP -0.332076264197257 1.58885695452918e-09 NA NA NA hsa-miR-181b-5p PRKCA 2.49307679431293 3.92829250217627e-20 -1.04253532292201 0.000330447904822586 mirMAP -0.255352495229191 2.20407502467148e-07 NA NA NA hsa-miR-181c-5p PRKCA 1.58587920618301 1.57506918816933e-10 -1.04253532292201 0.000330447904822586 mirMAP -0.187181736198993 0.000814130560426752 NA NA NA hsa-miR-183-5p PRKCA 4.19757025992371 4.79612296318304e-26 -1.04253532292201 0.000330447904822586 miRNATAP -0.167765439348368 3.7027196892035e-07 NA NA NA hsa-miR-186-5p PRKCA 1.47445398888668 3.0781726595413e-15 -1.04253532292201 0.000330447904822586 miRNATAP -0.372737117584225 3.41129073481267e-07 NA NA NA hsa-miR-193b-3p PRKCA 2.25711804611899 4.1940744806631e-14 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.184015097403191 5.6276271806172e-05 NA NA NA hsa-miR-193b-5p PRKCA 1.59567208918739 4.89398272459427e-08 -1.04253532292201 0.000330447904822586 mirMAP -0.144499830970602 0.00240910945358069 NA NA NA hsa-miR-194-5p PRKCA 1.8992998339217 3.76507853301977e-10 -1.04253532292201 0.000330447904822586 mirMAP -0.109824345513618 0.0163784009426493 NA NA NA hsa-miR-1976 PRKCA 2.06550563678192 7.81396978619772e-18 -1.04253532292201 0.000330447904822586 miRNATAP -0.17995688234711 0.00150164194068263 NA NA NA hsa-miR-19b-1-5p PRKCA 2.57951428759379 4.31576118703427e-20 -1.04253532292201 0.000330447904822586 mirMAP -0.172921934994649 0.000451924002079924 NA NA NA hsa-miR-200b-3p PRKCA 3.78235093249346 3.18343003239465e-14 -1.04253532292201 0.000330447904822586 TargetScan -0.114961109829389 2.45352651543255e-05 NA NA NA hsa-miR-200c-3p PRKCA 3.50132673580082 2.42716349086937e-15 -1.04253532292201 0.000330447904822586 miRNATAP -0.158977004957444 1.80034178057763e-07 NA NA NA hsa-miR-214-3p PRKCA -0.176344800034733 0.642485503428886 -1.04253532292201 0.000330447904822586 mirMAP -0.126245731078837 0.000711043186976772 NA NA NA hsa-miR-22-5p PRKCA 1.88011544159252 1.63978222572222e-16 -1.04253532292201 0.000330447904822586 mirMAP -0.258621101167742 1.45994385651039e-05 NA NA NA hsa-miR-24-2-5p PRKCA 2.07171035460647 3.15853539996136e-16 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.190869345201713 0.000384051796932142 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-27b-5p PRKCA 0.393316367667332 0.051702301924024 -1.04253532292201 0.000330447904822586 mirMAP -0.181077230744967 0.0103353868203874 NA NA NA hsa-miR-29a-5p PRKCA 1.46749674755271 3.34605004270294e-07 -1.04253532292201 0.000330447904822586 mirMAP -0.116181034245498 0.0240473974034834 NA NA NA hsa-miR-339-5p PRKCA 2.68710938429893 3.03134080808154e-16 -1.04253532292201 0.000330447904822586 mirMAP -0.146901538113986 0.000377758588526939 NA NA NA hsa-miR-340-5p PRKCA 0.30282999308409 0.157744789519131 -1.04253532292201 0.000330447904822586 mirMAP -0.170164525906013 0.0105648791339338 NA NA NA hsa-miR-3607-3p PRKCA 2.68532138541128 5.66716351955047e-14 -1.04253532292201 0.000330447904822586 mirMAP -0.141547181715678 0.000312501141538225 NA NA NA hsa-miR-362-5p PRKCA 1.59303749908759 9.582675908797e-08 -1.04253532292201 0.000330447904822586 TargetScan;miRNATAP -0.155938176693359 0.000821123203239911 NA NA NA hsa-miR-369-3p PRKCA 0.946781510019564 0.00134850306966842 -1.04253532292201 0.000330447904822586 PITA;miRNATAP -0.153415665611504 0.0013232753592926 NA NA NA hsa-miR-374a-3p PRKCA 0.533309330504947 0.00192918429705142 -1.04253532292201 0.000330447904822586 mirMAP -0.212668766216719 0.0105683237172046 NA NA NA hsa-miR-381-3p PRKCA -0.0821432056113931 0.752465205603634 -1.04253532292201 0.000330447904822586 mirMAP -0.182718955463403 0.000792478176257635 NA NA NA hsa-miR-429 PRKCA 4.48815175680773 2.44117492218206e-17 -1.04253532292201 0.000330447904822586 miRanda;miRNATAP -0.108496235247986 1.950717922572e-05 NA NA NA hsa-miR-450b-5p PRKCA 1.69244418548325 1.68064054148881e-10 -1.04253532292201 0.000330447904822586 PITA;mirMAP;miRNATAP -0.164559118659435 0.00164963824183995 NA NA NA hsa-miR-495-3p PRKCA -0.0847115949846082 0.763475496144456 -1.04253532292201 0.000330447904822586 mirMAP -0.121754283625337 0.0161312777156309 NA NA NA hsa-miR-500a-5p PRKCA 1.72110365584658 3.0807246212659e-10 -1.04253532292201 0.000330447904822586 miRNATAP -0.224298470556856 8.73025451195054e-06 NA NA NA hsa-miR-501-5p PRKCA 1.93654809410041 1.3779381780759e-10 -1.04253532292201 0.000330447904822586 miRNATAP -0.160491119587112 0.000665161220237392 NA NA NA hsa-miR-505-3p PRKCA 1.45322244209148 8.86597629645867e-10 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.17319300539973 0.00317185860747904 NA NA NA hsa-miR-505-5p PRKCA 1.89243395287645 9.82003586561819e-12 -1.04253532292201 0.000330447904822586 mirMAP -0.170760296141889 0.000583545058780229 NA NA NA hsa-miR-532-3p PRKCA 1.96631878320218 4.53421954361695e-13 -1.04253532292201 0.000330447904822586 mirMAP;miRNATAP -0.153994961004655 0.00236643084778704 NA NA NA hsa-miR-590-3p PRKCA 2.59289455139753 1.03200520972022e-21 -1.04253532292201 0.000330447904822586 PITA;miRanda;mirMAP;miRNATAP -0.257692443896068 3.43649017566933e-07 NA NA NA hsa-miR-92a-3p PRKCA 2.06460102658973 1.44784291084757e-19 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.177264968474978 0.0028853007950597 NA NA NA hsa-miR-93-3p PRKCA 2.85383869771942 5.64481766902125e-23 -1.04253532292201 0.000330447904822586 mirMAP -0.164593044407034 0.000371570157401047 NA NA NA hsa-let-7a-3p PRLR 1.42015538786275 7.03375209382654e-13 -0.790590749858476 0.188888563043757 mirMAP -0.410930934968385 0.00444831743628397 NA NA NA hsa-let-7b-3p PRLR 0.868207752019623 1.30460056774366e-05 -0.790590749858476 0.188888563043757 mirMAP -0.368318214729378 0.0118833221775601 NA NA NA hsa-let-7b-5p PRLR 0.604314269683977 0.00140009936153214 -0.790590749858476 0.188888563043757 miRNATAP -0.311530653616113 0.0450390049070614 NA NA NA hsa-miR-16-1-3p PRLR 2.56983217111073 3.02262181237943e-20 -0.790590749858476 0.188888563043757 mirMAP -0.227380496604895 0.0269629972392577 NA NA NA hsa-miR-200b-3p PRLR 3.78235093249346 3.18343003239465e-14 -0.790590749858476 0.188888563043757 mirMAP -0.122169074003695 0.0308179114598278 NA NA NA hsa-miR-200c-3p PRLR 3.50132673580082 2.42716349086937e-15 -0.790590749858476 0.188888563043757 mirMAP -0.150743243476538 0.0177144148281411 NA NA NA hsa-miR-22-5p PRLR 1.88011544159252 1.63978222572222e-16 -0.790590749858476 0.188888563043757 mirMAP -0.298102174954654 0.0161014751270785 NA NA NA hsa-miR-26b-5p PRLR 0.885393662798425 3.2116297961629e-06 -0.790590749858476 0.188888563043757 mirMAP -0.406309663249685 0.00803289230720884 NA NA NA hsa-miR-29a-5p PRLR 1.46749674755271 3.34605004270294e-07 -0.790590749858476 0.188888563043757 mirMAP -0.217340448887585 0.0405888289616366 NA NA NA hsa-miR-429 PRLR 4.48815175680773 2.44117492218206e-17 -0.790590749858476 0.188888563043757 mirMAP -0.111168957062796 0.035150274126572 NA NA NA hsa-miR-455-5p PRLR 2.2582442061694 1.43472128037398e-13 -0.790590749858476 0.188888563043757 miRanda -0.277599318349269 0.00270712336119311 NA NA NA hsa-miR-582-5p PRLR 0.609226359812689 0.032988717891497 -0.790590749858476 0.188888563043757 PITA -0.596275672219836 2.88630273165367e-09 NA NA NA hsa-miR-944 PRLR 2.91186649218281 1.31574753528144e-06 -0.790590749858476 0.188888563043757 mirMAP -0.37935134274492 1.75332303661758e-15 NA NA NA hsa-miR-103a-3p PTEN 1.44083190496858 1.53799939616416e-13 -0.452835975443078 0.00142504206837966 miRNAWalker2_validate;miRTarBase -0.181124200363514 1.1176220548008e-07 26511107;24828205 LncRNA GAS5 induces PTEN expression through inhibiting miR 103 in endometrial cancer cells; To investigate the expression of GAS5 PTEN and miR-103 RT-PCR was performed; Finally we found that miR-103 mimic could decrease the mRNA and protein levels of PTEN through luciferase reporter assay and western blotting and GAS5 plasmid may reverse this regulation effect in endometrial cancer cells; Through inhibiting the expression of miR-103 GAS5 significantly enhanced the expression of PTEN to promote cancer cell apoptosis and thus could be an important mediator in the pathogenesis of endometrial cancer;Our data collectively demonstrate that miR-103 is an oncogene miRNA that promotes colorectal cancer proliferation and migration through down-regulation of the tumor suppressor genes DICER and PTEN ; endometrial cancer;colorectal cancer hsa-miR-106a-5p PTEN 2.48882002962836 1.99757727374521e-12 -0.452835975443078 0.00142504206837966 miRNATAP -0.119115957971973 1.32932348443908e-10 26097565;26318586 miR 106a promotes growth and metastasis of non small cell lung cancer by targeting PTEN; Furthermore the presence of miR-106a was inversely correlated with PTEN in NSCLC tissues; Overall this study suggested that miR-106a inhibited the growth and metastasis of NSCLC cells by decreasing PTEN expression;Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo metastasis; lung squamous cell cancer;prostate cancer hsa-miR-106b-5p PTEN 2.46782146831112 1.36171495805632e-23 -0.452835975443078 0.00142504206837966 miRNAWalker2_validate;miRTarBase;miRNATAP -0.167925855213166 9.91778363511573e-11 24842611;26238857;26722252 MicroRNA 106b in cancer associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN;We further identified PTEN and p21 as novel direct targets of miR-106b by using target prediction algorithms and a luciferase assay; Overexpression of miR-106b reduced the expression of PTEN and p21 and increased the expression of p-AKT which is a downstream of PTEN; Restoring the expression of PTEN or p21 in stably miR-106b-overexpressed cells could rescue the effect of miR-106b on cell radioresistance; These observations illustrated that miR-106b could induce cell radioresistance by directly targeting PTEN and p21 this process was accompanied by tumour-initiating cell capacity enhancement which is universally confirmed to be associated with radioresistance;Cantharidin modulates the E2F1/MCM7 miR 106b 93/p21 PTEN signaling axis in MCF 7 breast cancer cells cell migration;drug resistance; gastric cancer;colorectal cancer;breast cancer hsa-miR-107 PTEN 1.30977326593435 1.30372468603965e-11 -0.452835975443078 0.00142504206837966 miRNAWalker2_validate;PITA;miRanda -0.125872445510677 0.000311847826997376 NA NA NA hsa-miR-130a-3p PTEN 2.02021855058359 1.26427102520415e-11 -0.452835975443078 0.00142504206837966 MirTarget;miRNATAP -0.107066992505531 1.60679955529776e-06 26837847;24490491;27062783;22614869;27040383;27035216;26043084 The miR 130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN; In clinical bladder cancer specimens downregulation of PTEN was found to be closely correlated with miR-130 family expression levels;Down-regulated miR-130a did not affect cell proliferations but enhanced the sensitivity of the cells to cisplatin inhibited the expressions of MDR1 mRNA and P-gp and increased the expression of PTEN proteins; MiR-130a inhibitor can reverse the cisplatin resistance by upregulating the expression of PTEN proteins and down-regulating P-gp in A2780 cell lines;Platinum-resistant patients had significantly higher levels of expression of miR-130a and BCL-2 and lower level of PTEN than platinum-sensitive patients P < 0.05; MiR-130a may mediate the generation of platinum resistance in epithelial ovarian cancer through inhibiting PTEN to activate PI3K/AKT signaling pathway and increasing BCL-2 to inhibit tumor cell apoptosis;We found that miR-130a was upregulated in SKOV3/CIS compared to the parental SKOV3 cells and PTEN was predicted to be the potential target of miR-130a;In addition by targeting PTEN 3' untranslated region miR-130a might increase cell growth and initiate protein kinase B AKT pathway activation;MicroRNA 130a promotes the metastasis and epithelial mesenchymal transition of osteosarcoma by targeting PTEN; MiR-130a exerted promoting effects on metastatic behavior and EMT of osteosarcoma cells through suppressing PTEN expression;This role of miR-130a may be achieved by regulating the MDR1 and PTEN gene expression cell migration;drug resistance;drug resistance;;;metastasis; bladder cancer;ovarian cancer;ovarian cancer;ovarian cancer;cervical and endocervical cancer;sarcoma;ovarian cancer hsa-miR-130b-3p PTEN 3.5350292994509 1.73934183852569e-27 -0.452835975443078 0.00142504206837966 MirTarget;miRNATAP -0.118523549020844 1.10168456648735e-09 26837847;25637514 The miR 130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN; In clinical bladder cancer specimens downregulation of PTEN was found to be closely correlated with miR-130 family expression levels;MiR 130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells; We confirmed that miR-130b interacted with the 3'-untranslated region of PTEN and that an increase in the expression level of miR-130b negatively affected the protein level of PTEN; However the dysregulation of miR-130b had no obvious impact on PTEN mRNA; As Akt is a downstream effector of PTEN we explored if miR-130b affected Akt expression and found that miR-130b indirectly regulated the level of phosphorylated Akt while total Akt protein remained unchanged; The results indicate that miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation which would be helpful in developing miRNA-based treatments for ESCC cell migration; bladder cancer;esophageal cancer hsa-miR-148a-3p PTEN 1.26728238710376 2.52325607402829e-06 -0.452835975443078 0.00142504206837966 MirTarget;miRNATAP -0.102658849708203 4.6220389940495e-05 22496917 Introduction of anti-miR-148a increased PTEN protein and mRNA expression suggesting that PTEN was targeted by miR-148a liver cancer hsa-miR-148b-3p PTEN 1.97815018171325 6.07715327281595e-26 -0.452835975443078 0.00142504206837966 MirTarget;miRNATAP -0.168985576302433 9.27873273241405e-07 NA NA NA hsa-miR-15b-3p PTEN 2.33847028227712 4.29662877950836e-19 -0.452835975443078 0.00142504206837966 mirMAP -0.110608587315208 9.86982828042873e-06 NA NA NA hsa-miR-16-2-3p PTEN 2.31623086727196 4.29838149388188e-20 -0.452835975443078 0.00142504206837966 mirMAP -0.10224879739163 8.32790317307332e-05 NA NA NA hsa-miR-17-5p PTEN 3.2710598467455 9.93128340539455e-27 -0.452835975443078 0.00142504206837966 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.128957385840206 5.08699518968894e-10 27400681;23391506;23133552;26629823;24462867;26318586;26215320;25634356;26500892;24912422;23418359 GFRα2 prompts cell growth and chemoresistance through down regulating tumor suppressor gene PTEN via Mir 17 5p in pancreatic cancer; Mechanically we discovered that high GFRα2 expression level leads to PTEN inactivation via enhancing Mir-17-5p level;We found that these phenotypes were the results of miR-17 targeting PTEN;PTEN mRNA correlated inversely with miR-92a and members of the miR-17 and miR-130/301 families;We hypothesized that knocking down the oncogenic microRNA oncomiR miR-17-5p might restore the expression levels of PDCD4 and PTEN tumor suppressor proteins illustrating a route to oligonucleotide therapy of TNBC; Contrary to conventional wisdom antisense knockdown of oncomiR miR-17-5p guide strand reduced PDCD4 and PTEN proteins by 1.8±0.3 fold in human TNBC cells instead of raising them; Bioinformatics analysis and folding energy calculations revealed that mRNA targets of miR-17-5p guide strand such as PDCD4 and PTEN could also be regulated by miR-17-3p passenger strand;miR 17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression; Expression of miR-17 was negatively correlated with PTEN in OS tissues;Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR 17 family in prostate cancer; Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo;In addition ERβ expression significantly increased in calycosin-treated HCT-116 cells followed by a decrease of miR-17 and up-regulation of PTEN; Our results indicate that calycosin has an inhibitory effect on CRC which might be obtained by ERβ-mediated regulation of miR-17 and PTEN expression;The High Expression of the microRNA 17 92 Cluster and its Paralogs and the Downregulation of the Target Gene PTEN Is Associated with Primary Cutaneous B Cell Lymphoma Progression;MicroRNA 17 5p induces drug resistance and invasion of ovarian carcinoma cells by targeting PTEN signaling; miR-17-5p activates AKT by downregulation of PTEN in ovarian cancer cells;MicroRNA 17 5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression; We found that PTEN was a target of miR-17-5p in the colon cancer cells and their context-specific interactions were responsible for multiple drug-resistance; Chemotherapy was found to increase the expression levels of miR-17-5p which further repressed PTEN levels contributing to the development of chemo-resistance; MiR-17-5p is a predictive factor for chemotherapy response and a prognostic factor for overall survival in CRC which is due to its regulation of PTEN expression;The mature miR-17-5p exerted this function by repressing the expression of PTEN drug resistance;;;;metastasis;;;progression;drug resistance;metastasis;drug resistance;poor survival; pancreatic cancer;glioblastoma;sarcoma;breast cancer;sarcoma;prostate cancer;colorectal cancer;B cell lymphoma;ovarian cancer;colorectal cancer;liver cancer hsa-miR-181c-5p PTEN 1.58587920618301 1.57506918816933e-10 -0.452835975443078 0.00142504206837966 MirTarget;miRNATAP -0.127904121862523 2.20738602419631e-06 25695913 miR 181c promotes proliferation via suppressing PTEN expression in inflammatory breast cancer; In this study we showed that miR-181c as an oncogene promoted proliferation and it inhibited PTEN protein expression by targeting 3'-UTR of PTEN mRNA in IBC SUM149 cells; Thus targeting miR-181c and restoration of PTEN can be used in conjunction with other therapies to prevent progression of IBC progression breast cancer hsa-miR-181d-5p PTEN 1.52204912185579 9.2693319057748e-08 -0.452835975443078 0.00142504206837966 MirTarget -0.117066047918988 7.16131240625052e-07 27006767 Moreover hsa-miR-181d was upregulated to control expression a tumor suppressor gene PTEN to protect the cancer cell from apoptosis endometrial cancer hsa-miR-186-5p PTEN 1.47445398888668 3.0781726595413e-15 -0.452835975443078 0.00142504206837966 mirMAP;miRNATAP -0.221807059815679 3.24247402491438e-10 NA NA NA hsa-miR-188-5p PTEN 2.52825126596644 6.78099435999778e-14 -0.452835975443078 0.00142504206837966 MirTarget;PITA;miRNATAP -0.109812572617288 1.33705979957174e-07 NA NA NA hsa-miR-18a-5p PTEN 3.78535678765353 3.72446596213886e-26 -0.452835975443078 0.00142504206837966 miRNAWalker2_validate;miRTarBase -0.11423116163821 1.11808022110275e-09 24681249;27291152 However higher levels of the miR-17~92 cluster switched from PTEN to oncogenes including Ctnnb1 β-catenin via miR-18a which resulted in inhibition of tumor growth and metastasis;miR 18a promotes cell proliferation of esophageal squamous cell carcinoma cells by increasing cylin D1 via regulating PTEN PI3K AKT mTOR signaling axis metastasis; colon cancer;esophageal cancer hsa-miR-193a-3p PTEN 1.60460546928078 2.86169793322984e-07 -0.452835975443078 0.00142504206837966 PITA;miRanda -0.105979704931185 8.32668652705572e-07 26753960;23223432 Downregulation of microRNA 193 3p inhibits tumor proliferation migration and chemoresistance in human gastric cancer by regulating PTEN gene;Our study identifies miR-193a and PTEN as targets for AML1/ETO and provides evidence that links the epigenetic silencing of tumor suppressor genes miR-193a and PTEN to differentiation block of myeloid precursors drug resistance;differentiation gastric cancer;acute myeloid leukemia hsa-miR-19a-3p PTEN 3.42309334186656 3.02671914353412e-28 -0.452835975443078 0.00142504206837966 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.128463306420323 2.55472255726088e-10 25107371;27445062;26098000;24831732;21853360;24681249;27289489 The target of miR-19a was identified by western blot and whether its regulatory role depends on its target was improved by a rescue experiment with miR-19a mimic and PTEN expression plasmid; Meanwhile gain or loss of function of miR-19a demonstrated that miR-19a can promote cell growth of bladder cancer cells and the further mechanism studies indicated that its oncogenic role was dependent on targeting PTEN; The oncogenic role of miR19a in bladder cancer was dependent on targeting PTEN;The target genes of miR-19a such as ABCA1 and PTEN that had been suppressed by miR recovered their expression through CAP treatment;Moreover siRNA-mediated knockdown of PTEN a target of miR-19 also resulted in EMT migration and invasion of A549 and HCC827 cells suggesting that PTEN is involved in miR-19-induced EMT migration and invasion of lung cancer cells;Meanwhile BPA-induced upregulation of oncogenic miR-19a and miR-19b and the dysregulated expression of miR-19-related downstream proteins including PTEN p-AKT p-MDM2 p53 and proliferating cell nuclear antigen were reversed by curcumin;Regulation of miR 19 to breast cancer chemoresistance through targeting PTEN; Expression levels of miR-19 in MDR cells were inversely consistent with those of PTEN; Our findings demonstrate for the first time involvement of miR-19 in multidrug resistance through modulation of PTEN and suggest that miR-19 may be a potential target for preventing and reversing MDR in tumor cells;miR-19 in the context of the miR-17~92 cluster at medium levels promoted tumor metastasis through induction of Wnt/β-catenin-mediated epithelial-mesenchymal transition by targeting to the tumor-suppressor gene PTEN;Transfection of miR-19a and -19b mimics reversed the up-regulations of IGF2R and PTEN gene expression and abrogated the GSE induced anti-proliferative response ;;;;drug resistance;metastasis;drug resistance bladder cancer;breast cancer;lung cancer;breast cancer;breast cancer;colon cancer;lung cancer hsa-miR-19b-3p PTEN 2.49529833021187 1.57028265846699e-23 -0.452835975443078 0.00142504206837966 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.17043189646512 2.79115195694575e-11 26098000;24831732;21853360;24681249 Moreover siRNA-mediated knockdown of PTEN a target of miR-19 also resulted in EMT migration and invasion of A549 and HCC827 cells suggesting that PTEN is involved in miR-19-induced EMT migration and invasion of lung cancer cells;Meanwhile BPA-induced upregulation of oncogenic miR-19a and miR-19b and the dysregulated expression of miR-19-related downstream proteins including PTEN p-AKT p-MDM2 p53 and proliferating cell nuclear antigen were reversed by curcumin;Regulation of miR 19 to breast cancer chemoresistance through targeting PTEN; Expression levels of miR-19 in MDR cells were inversely consistent with those of PTEN; Our findings demonstrate for the first time involvement of miR-19 in multidrug resistance through modulation of PTEN and suggest that miR-19 may be a potential target for preventing and reversing MDR in tumor cells;miR-19 in the context of the miR-17~92 cluster at medium levels promoted tumor metastasis through induction of Wnt/β-catenin-mediated epithelial-mesenchymal transition by targeting to the tumor-suppressor gene PTEN ;;drug resistance;metastasis lung cancer;breast cancer;breast cancer;colon cancer hsa-miR-20a-5p PTEN 3.15577933619191 4.19753346442454e-25 -0.452835975443078 0.00142504206837966 miRNAWalker2_validate;miRTarBase;miRNATAP -0.12193642920165 5.77479259337628e-09 26031366 The expression of miR-20a and PTEN were detected in HCC cell lines and paired primary tissues by quantitative real-time polymerase chain reaction; MiR-20a levels were increased in HCC cell lines and tissues whereas PTEN was inversely correlated with it; PTEN was identified as a direct functional target of miR-20a for the induction of radioresistance drug resistance liver cancer hsa-miR-25-3p PTEN 1.36472605225697 4.83790725935681e-11 -0.452835975443078 0.00142504206837966 miRTarBase;MirTarget;miRNATAP -0.196462680546189 9.04767751306264e-10 NA NA NA hsa-miR-28-5p PTEN 0.230152919654905 0.0742909586754846 -0.452835975443078 0.00142504206837966 miRanda -0.112241090761127 0.0418761338534022 NA NA NA hsa-miR-301a-3p PTEN 2.81024345929638 2.29784847962242e-17 -0.452835975443078 0.00142504206837966 MirTarget;miRNATAP -0.123344981900917 2.76158051949627e-09 24315818;26846737 Upregulated microRNA 301a in breast cancer promotes tumor metastasis by targeting PTEN and activating Wnt/β catenin signaling; Furthermore miR-301a directly targeted and suppressed PTEN one negative regulator of the Wnt/β-catenin signaling cascade; These results demonstrate that miR-301a maintains constitutively activated Wnt/β-catenin signaling by directly targeting PTEN which promotes breast cancer invasion and metastasis;MicroRNA 301a promotes cell proliferation via PTEN targeting in Ewing's sarcoma cells; Our results demonstrated the novel mechanism controlling PTEN expression via miR-301a in ES cells metastasis; breast cancer;sarcoma hsa-miR-30b-5p PTEN 0.800822374912712 0.000133601914525413 -0.452835975443078 0.00142504206837966 mirMAP -0.15403930655305 2.2546089672267e-06 NA NA NA hsa-miR-30c-5p PTEN 0.778774633108 0.000285599212429136 -0.452835975443078 0.00142504206837966 mirMAP -0.150378554405459 2.29281374408959e-06 NA NA NA hsa-miR-30d-3p PTEN 0.977747550180601 4.3048212205381e-05 -0.452835975443078 0.00142504206837966 MirTarget;miRNATAP -0.119783791946268 2.73757307106354e-05 NA NA NA hsa-miR-30d-5p PTEN 0.675423997639582 0.00270618816039773 -0.452835975443078 0.00142504206837966 mirMAP -0.11072634618103 0.000287709940594657 NA NA NA hsa-miR-30e-5p PTEN 1.23904909539663 1.35561917122157e-09 -0.452835975443078 0.00142504206837966 mirMAP -0.160981204851498 1.03953643650469e-06 NA NA NA hsa-miR-32-5p PTEN 2.34056473219422 6.24134585974322e-20 -0.452835975443078 0.00142504206837966 MirTarget;miRNATAP -0.145568223802877 9.281864133748e-09 24123284;25647261;23617834 In this study we determined the levels of the correlation between and the clinical significance of the expression of miR-32 and phosphatase and tensin homologue PTEN a tumor suppressor targeted by miR-32 in CRC; The levels of miR-32 and PTEN gene expression in 35 colorectal carcinoma samples 35 corresponding cancer-adjacent tissue samples 27 colorectal adenoma samples and 16 normal tissue samples were quantified using real-time quantitative reverse transcriptase-polymerase chain reaction; The relationship between the miR-32 and PTEN protein expression and clinicopathological factors was analyzed; Significant upregulation of miR-32 expression and reduction of PTEN were identified in CRC tissues; An inverse relationship between miR-32 and PTEN protein expression was identified; MiR-32 and PTEN expression were inversely correlated and miR-32 may be associated with the development of CRC;MiR 32 induces cell proliferation migration and invasion in hepatocellular carcinoma by targeting PTEN; Besides miRNA-32 down-regulates PTEN through binding to 3'-UTR of PTEN mRNA from luciferase reporter assay and the expression level of miR-32 could affect the proliferation migration and invasion of liver cancer cell lines via PTEN/Akt signaling pathway; Down-expression of PTEN could significantly attenuate the inhibitory effects of knockdown miR-32 on the proliferation migration and invasion of liver cancer cells suggesting that miR-32 could be a potential target for HCC treatment;MicroRNA 32 miR 32 regulates phosphatase and tensin homologue PTEN expression and promotes growth migration and invasion in colorectal carcinoma cells; In this study we identified the potential effects of miR-32 on some important biological properties of CRC cells and clarified the regulation of PTEN by miR-32; The 3'-untranslated region 3'-UTR of PTEN combined with miR-32 was verified by dual-luciferase reporter assay; Gain-of-function and loss-of-function studies showed that overexpression of miR-32 promoted SW480 cell proliferation migration and invasion reduced apoptosis and resulted in downregulation of PTEN at a posttranscriptional level; However miR-32 knock-down inhibited these processes in HCT-116 cells and enhanced the expression of PTEN protein; In addition we further identified PTEN as the functional downstream target of miR-32 by directly targeting the 3'-UTR of PTEN; Our results demonstrated that miR-32 was involved in tumorigenesis of CRC at least in part by suppression of PTEN ;;tumorigenesis colorectal cancer;liver cancer;colorectal cancer hsa-miR-362-3p PTEN 2.0756816987665 3.89026064579331e-12 -0.452835975443078 0.00142504206837966 miRanda -0.115158238382692 5.24016404806603e-07 NA NA NA hsa-miR-363-3p PTEN 1.50575300026701 0.00020976164678918 -0.452835975443078 0.00142504206837966 MirTarget;miRNATAP -0.100220872472703 1.35166197069511e-09 NA NA NA hsa-miR-374a-5p PTEN 0.484615721953736 0.0042981729815149 -0.452835975443078 0.00142504206837966 MirTarget;mirMAP -0.154385867426133 0.000159063773613779 NA NA NA hsa-miR-374b-5p PTEN 0.0654362503857184 0.722673188879465 -0.452835975443078 0.00142504206837966 MirTarget;mirMAP;miRNATAP -0.119395270830768 0.00157844251632807 NA NA NA hsa-miR-421 PTEN 1.17791565395543 6.78526676976629e-06 -0.452835975443078 0.00142504206837966 miRanda -0.116149976062421 7.77520989006685e-06 NA NA NA hsa-miR-425-5p PTEN 3.07071373939774 4.02947460586085e-25 -0.452835975443078 0.00142504206837966 miRNATAP -0.139167264143658 8.36425767948797e-11 25154996 An increase in miR-425 depended upon IL-1β-induced NF-kappaB activation.Repression of PTEN by miR-425 promoted gastric cancer cell proliferation gastric cancer hsa-miR-454-3p PTEN 2.47234127820054 1.12878018736016e-21 -0.452835975443078 0.00142504206837966 MirTarget;miRNATAP -0.143498211514651 2.3895399060586e-08 26296312;27261580 MicroRNA 454 functions as an oncogene by regulating PTEN in uveal melanoma; Furthermore we identified PTEN as a direct target of miR-454; Our data revealed that ectopic expression of PTEN restored the effects of miR-454 on cell proliferation and invasion in uveal melanoma cells;MiR 454 promotes the progression of human non small cell lung cancer and directly targets PTEN; At last the potential regulatory function of miR-454 on PTEN expression was confirmed; Further PTEN was confirmed as a direct target of miR-454 by using Luciferase Reporter Assay ;progression melanoma;lung squamous cell cancer hsa-miR-484 PTEN 1.81844463411787 1.82951571230938e-15 -0.452835975443078 0.00142504206837966 miRNATAP -0.123242919063894 2.18866967044909e-05 NA NA NA hsa-miR-532-5p PTEN 1.55697650978597 1.57884735535196e-11 -0.452835975443078 0.00142504206837966 PITA;mirMAP;miRNATAP -0.144490491618683 5.83499130267459e-07 NA NA NA hsa-miR-590-5p PTEN 3.18300989862077 2.06813568597893e-26 -0.452835975443078 0.00142504206837966 mirMAP -0.121253713178443 3.04555241061884e-08 23803188 Targetscan predicted PDCD4 and PTEN as the potential target genes of miR-590-5p and miR-590-3p which was verified by luciferase reporter system and Western blotting liver cancer hsa-miR-7-1-3p PTEN 1.84950311431067 1.25300363397654e-13 -0.452835975443078 0.00142504206837966 mirMAP -0.133579523943701 4.98334583211167e-07 NA NA NA hsa-miR-92a-3p PTEN 2.06460102658973 1.44784291084757e-19 -0.452835975443078 0.00142504206837966 MirTarget;miRNATAP -0.175671660591697 6.62046894313789e-10 26432332;25515201;24137349;23546593;23133552;24026406 Downregulation of PTEN could mimic the same effects of miR-92a mimic in NSCLC cells and rescue the effects on NSCLC cells induced by miR-92a inhibitor; Taken together these findings suggested that miR-92a could promote growth metastasis and chemoresistance in NSCLC cells at least partially by targeting PTEN;MiR 92a Promotes Cell Metastasis of Colorectal Cancer Through PTEN Mediated PI3K/AKT Pathway; The expression of miR-92a PTEN and E-cadherin was analyzed by real-time PCR; In addition there was a negative correlation between levels of miR-92a and the PTEN gene p < 0.0001; The association of levels of miR-92a and PTEN with tumor cell migration in CRC was also confirmed in CRC cell models;MicroRNA miR-92 is overexpressed in a number of tumors and has been proven to negatively regulate a number of tumor suppressor genes including phosphatase and tensin homologue PTEN; PTEN protein expression was decreased in the SiHa cells that were transfected with the miR-92 mimic; The data indicated that miR-92 may increase the migration and invasion of SiHa cells partially through the downregulation of PTEN protein expression;Expression and significance of PTEN and miR 92 in hepatocellular carcinoma; Immunohistochemistry streptavidin-peroxidase SP and quantitative reverse transcriptase-polymerase chain reaction qRT‑PCR were used to detect the expression of PTEN and miR-92 in 15 cases of HCC and the corresponding paracancerous tissues; The correlation between PTEN and miR-92 was analyzed; Additionally the mRNA levels of PTEN and miR-92 showed a significantly negative correlation with each other r=-0.858 P<0.05; In conclusion PTEN and miR-92 have different roles in the development of HCC; The combined detection of PTEN and miR-92 may provide critical clinical evidence for the early diagnosis and prognosis of HCC;PTEN mRNA correlated inversely with miR-92a and members of the miR-17 and miR-130/301 families;The expression levels of miR-92a and phosphatase and tensin homologue PTEN were detected by qRT-PCR and western blot; In addition the regulation of PTEN by miR-92a was evaluated by qRT-PCR western blot and luciferase reporter assays; There was an inverse correlation between the levels of miR-92a and PTEN in CRC tissues; The overexpression of miR-92a in CRC cells decreased PTEN expression at the translational level and decreased PTEN-driven luciferase-reporter activity; Our results demonstrated that miR-92a induced EMT and regulated cell growth migration and invasion in the SW480 cells at least partially via suppression of PTEN expression metastasis;drug resistance;metastasis;cell migration;;worse prognosis;; lung squamous cell cancer;colorectal cancer;cervical and endocervical cancer;liver cancer;sarcoma;colorectal cancer hsa-miR-92b-3p PTEN 1.20409245530001 3.41055816361655e-06 -0.452835975443078 0.00142504206837966 MirTarget;miRNATAP -0.114974293673639 1.10439131275336e-05 24099768;26878388;24137349;23546593 MiR 92b regulates the cell growth cisplatin chemosensitivity of A549 non small cell lung cancer cell line and target PTEN; Furthermore we found miR-92b could directly target PTEN a unique tumor suppressor gene which was downregulated in lung cancer tissues compared to the matched adjacent normal tissues;We revealed that patients exhibiting an upregulation of hsa-miR-92b and patients with deletions of PTEN did not tend to overlap and hsa-miR-92b and PTEN coordinately regulated the pathway of 'cell cycle' and so on;MicroRNA miR-92 is overexpressed in a number of tumors and has been proven to negatively regulate a number of tumor suppressor genes including phosphatase and tensin homologue PTEN; PTEN protein expression was decreased in the SiHa cells that were transfected with the miR-92 mimic; The data indicated that miR-92 may increase the migration and invasion of SiHa cells partially through the downregulation of PTEN protein expression;Expression and significance of PTEN and miR 92 in hepatocellular carcinoma; Immunohistochemistry streptavidin-peroxidase SP and quantitative reverse transcriptase-polymerase chain reaction qRT‑PCR were used to detect the expression of PTEN and miR-92 in 15 cases of HCC and the corresponding paracancerous tissues; The correlation between PTEN and miR-92 was analyzed; Additionally the mRNA levels of PTEN and miR-92 showed a significantly negative correlation with each other r=-0.858 P<0.05; In conclusion PTEN and miR-92 have different roles in the development of HCC; The combined detection of PTEN and miR-92 may provide critical clinical evidence for the early diagnosis and prognosis of HCC ;;;worse prognosis lung squamous cell cancer;breast cancer;cervical and endocervical cancer;liver cancer hsa-miR-93-5p PTEN 3.03961860136032 1.11672209617395e-24 -0.452835975443078 0.00142504206837966 miRNAWalker2_validate;miRTarBase;miRNATAP -0.134735169835666 3.72873311860152e-10 25633810;26243299;22465665;26087719 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC;microRNA 93 promotes cell proliferation via targeting of PTEN in Osteosarcoma cells; An miRNA miR-93 was significantly up-regulated whereas phosphatase and tensin homologue PTEN expression was significantly down-regulated in all tested OS cells when compared with hMSCs; Ectopic expression of miR-93 decreased PTEN protein levels; Taking these observations together miR-93 can be seen to play a critical role in carcinogenesis through suppression of PTEN and may serve as a therapeutic target for the treatment of OS;Furthermore we found that miR-93 can directly target PTEN and participates in the regulation of the AKT signaling pathway; MiR-93 inversely correlates with PTEN expression in CDDP-resistant and sensitive human ovarian cancer tissues;Furthermore our study found berberine could inhibit miR-93 expression and function in ovarian cancer as shown by an increase of its target PTEN an important tumor suppressor in ovarian cancer; More importantly A2780 cells that were treated with PTEN siRNA had a survival pattern that is similar to cells with miR-93 overexpression ;tumorigenesis;;poor survival liver cancer;sarcoma;ovarian cancer;ovarian cancer hsa-let-7c-5p PTK2 -2.07847142524506 5.51224567263294e-09 0.31431677285734 0.0476564958514266 miRNAWalker2_validate -0.113450604453773 5.21892454913942e-08 NA NA NA hsa-miR-193a-3p PTK2 1.60460546928078 2.86169793322984e-07 0.31431677285734 0.0476564958514266 miRNAWalker2_validate;miRanda -0.109883142484797 4.78130386152767e-06 NA NA NA hsa-miR-374b-5p RAC1 0.0654362503857184 0.722673188879465 0.221936454340431 0.051549220692643 mirMAP -0.101573831955509 0.000746852128506454 NA NA NA hsa-miR-140-5p RBL2 0.844753502512594 3.73722278438606e-05 -0.598910927791217 0.000318998334086003 miRanda -0.11867323020571 0.00262978059184829 NA NA NA hsa-miR-142-5p RBL2 1.17581605694506 0.0018174701991234 -0.598910927791217 0.000318998334086003 PITA -0.103739178866545 9.11193439074471e-07 NA NA NA hsa-miR-576-5p RBL2 2.20467023993664 3.4053475193793e-19 -0.598910927791217 0.000318998334086003 MirTarget;PITA -0.126790145697504 5.30686012438181e-05 NA NA NA hsa-miR-107 RELN 1.30977326593435 1.30372468603965e-11 -4.70097153618157 2.41994737445055e-14 miRanda -0.864531155871559 2.37615647567707e-08 NA NA NA hsa-miR-10a-5p RELN 1.15016989191194 0.00372037233992369 -4.70097153618157 2.41994737445055e-14 miRNAWalker2_validate -0.434923604199382 1.19694323754989e-08 NA NA NA hsa-miR-128-3p RELN 1.63756041666078 6.79626586407187e-14 -4.70097153618157 2.41994737445055e-14 miRNAWalker2_validate;miRTarBase;MirTarget -0.992675879127048 1.26551313786224e-13 NA NA NA hsa-miR-144-5p RELN 0.195856574290527 0.61856475838049 -4.70097153618157 2.41994737445055e-14 MirTarget -0.287952778281414 0.000228635969575783 NA NA NA hsa-miR-15a-5p RELN 2.34669284378787 1.69544424500258e-23 -4.70097153618157 2.41994737445055e-14 MirTarget;miRNATAP -1.00666694290942 5.86693000076857e-17 NA NA NA hsa-miR-15b-5p RELN 1.57112623124278 9.14247846750597e-13 -4.70097153618157 2.41994737445055e-14 MirTarget;miRNATAP -0.959354256632084 7.43497345525197e-13 NA NA NA hsa-miR-16-5p RELN 1.75824877145857 1.68592440033108e-16 -4.70097153618157 2.41994737445055e-14 MirTarget;miRNATAP -1.02344802566157 5.96501787193487e-14 NA NA NA hsa-miR-200b-3p RELN 3.78235093249346 3.18343003239465e-14 -4.70097153618157 2.41994737445055e-14 MirTarget;TargetScan -0.487307419597792 2.67859187634648e-17 NA NA NA hsa-miR-200c-3p RELN 3.50132673580082 2.42716349086937e-15 -4.70097153618157 2.41994737445055e-14 MirTarget -0.654129820157615 6.78543521649521e-25 NA NA NA hsa-miR-205-5p RELN 4.1389800495524 2.05488295686453e-12 -4.70097153618157 2.41994737445055e-14 miRNATAP -0.49351556169278 8.68839147703351e-25 NA NA NA hsa-miR-224-5p RELN 2.94107125335675 5.72194099515157e-08 -4.70097153618157 2.41994737445055e-14 MirTarget -0.406443445261408 7.1442677199031e-14 NA NA NA hsa-miR-27a-3p RELN 1.66542180327138 4.93775737894805e-13 -4.70097153618157 2.41994737445055e-14 MirTarget;miRNATAP -0.769482198666094 2.20561978008177e-09 NA NA NA hsa-miR-27a-5p RELN 0.0545598990316276 0.869091561924187 -4.70097153618157 2.41994737445055e-14 miRNATAP -0.283909323353228 0.00233014001766655 NA NA NA hsa-miR-331-5p RELN 2.17414714166315 1.54547681391888e-18 -4.70097153618157 2.41994737445055e-14 MirTarget;miRNATAP -0.823854472640473 7.80157906579931e-12 NA NA NA hsa-miR-34a-5p RELN 1.9016323452565 1.43092834643601e-14 -4.70097153618157 2.41994737445055e-14 miRNATAP -0.794629260378451 2.12226011368403e-11 NA NA NA hsa-miR-361-5p RELN 0.971859117235239 5.30236555707088e-09 -4.70097153618157 2.41994737445055e-14 MirTarget;PITA;miRanda -0.985124584543506 6.73805550100544e-08 NA NA NA hsa-miR-421 RELN 1.17791565395543 6.78526676976629e-06 -4.70097153618157 2.41994737445055e-14 miRanda -0.438611973049058 0.000174869104938267 NA NA NA hsa-miR-424-5p RELN 1.61930224569578 1.89642549274994e-10 -4.70097153618157 2.41994737445055e-14 MirTarget;miRNATAP -0.419181480973208 0.00041750603445128 NA NA NA hsa-miR-429 RELN 4.48815175680773 2.44117492218206e-17 -4.70097153618157 2.41994737445055e-14 MirTarget;PITA;miRanda;miRNATAP -0.46299684688601 5.9766012292285e-18 NA NA NA hsa-miR-452-5p RELN 1.37180058737183 0.00171494843537772 -4.70097153618157 2.41994737445055e-14 MirTarget -0.418485216221363 1.22558878612084e-09 NA NA NA hsa-miR-455-3p RELN 3.06093594997644 3.54590649799868e-16 -4.70097153618157 2.41994737445055e-14 PITA -0.658771745315373 4.59265991282922e-18 NA NA NA hsa-miR-582-5p RELN 0.609226359812689 0.032988717891497 -4.70097153618157 2.41994737445055e-14 MirTarget;PITA -0.455537607087861 2.22078175511891e-05 NA NA NA hsa-miR-589-3p RELN 2.51971841868825 2.39125940264107e-11 -4.70097153618157 2.41994737445055e-14 MirTarget -0.465140320456586 2.24676091990783e-07 NA NA NA hsa-miR-590-3p RELN 2.59289455139753 1.03200520972022e-21 -4.70097153618157 2.41994737445055e-14 miRanda;miRNATAP -0.679484434038679 5.37290190631669e-10 NA NA NA hsa-miR-148a-3p RPTOR 1.26728238710376 2.52325607402829e-06 -0.479637741652061 5.89716317949949e-06 mirMAP -0.106505166600003 1.15705839238367e-08 NA NA NA hsa-miR-361-3p RPTOR 1.07367425434318 1.73142774168958e-09 -0.479637741652061 5.89716317949949e-06 MirTarget -0.136451834190925 1.55302428680942e-06 NA NA NA hsa-miR-107 SGK1 1.30977326593435 1.30372468603965e-11 -1.88801735228642 1.82096215766115e-07 miRanda -0.43836281036356 1.01034796229964e-06 NA NA NA hsa-miR-125a-3p SGK1 1.24490295132072 5.26925231010328e-06 -1.88801735228642 1.82096215766115e-07 miRanda -0.214144291771801 0.000895498888974788 NA NA NA hsa-miR-15a-5p SGK1 2.34669284378787 1.69544424500258e-23 -1.88801735228642 1.82096215766115e-07 miRNATAP -0.196795273361475 0.00621503045185564 NA NA NA hsa-miR-15b-5p SGK1 1.57112623124278 9.14247846750597e-13 -1.88801735228642 1.82096215766115e-07 miRNATAP -0.173203535854513 0.0288508185683693 NA NA NA hsa-miR-361-5p SGK1 0.971859117235239 5.30236555707088e-09 -1.88801735228642 1.82096215766115e-07 miRanda -0.522729584017362 7.19885086363231e-07 NA NA NA hsa-miR-542-3p SGK1 1.18832665895751 1.98700670691565e-07 -1.88801735228642 1.82096215766115e-07 miRanda -0.27993027227578 0.000273272540229196 NA NA NA hsa-miR-217 SGK2 0.608024397387488 0.199352491710517 0.844289092579627 0.254895501603777 miRanda -0.185918183145075 0.016988754314952 NA NA NA hsa-miR-30c-5p SGK3 0.778774633108 0.000285599212429136 0.052299603967112 0.734392969658286 miRNATAP -0.106613523805521 0.00207790566494273 NA NA NA hsa-miR-664a-3p SGK3 0.634721925861133 0.00520070178640421 0.052299603967112 0.734392969658286 mirMAP -0.121226326260323 0.000209512988316147 NA NA NA hsa-miR-132-3p SOS1 0.156276992635384 0.408190812100704 -0.16498215834071 0.203173827793335 miRNATAP -0.124479028859718 0.000189720665201441 NA NA NA hsa-miR-140-3p SOS1 0.0608890720479334 0.727716871248724 -0.16498215834071 0.203173827793335 miRNATAP -0.101782613385997 0.00502361468434803 NA NA NA hsa-miR-23a-3p SOS1 1.00493340843378 2.55313889288924e-08 -0.16498215834071 0.203173827793335 mirMAP -0.129314634656678 0.000166578408604821 NA NA NA hsa-miR-26a-2-3p SOS1 0.823520019989974 0.00017092160823769 -0.16498215834071 0.203173827793335 mirMAP -0.118538447529583 3.24943288286622e-05 NA NA NA hsa-miR-27a-3p SOS1 1.66542180327138 4.93775737894805e-13 -0.16498215834071 0.203173827793335 MirTarget;miRNATAP -0.122545061941616 3.0550593865242e-06 NA NA NA hsa-miR-30a-5p SOS1 -0.878357906436456 0.000509952992366057 -0.16498215834071 0.203173827793335 mirMAP;miRNATAP -0.11057365509939 6.32062418728583e-06 NA NA NA hsa-miR-140-5p SOS2 0.844753502512594 3.73722278438606e-05 -0.541773165962052 3.38343002773895e-05 miRanda -0.175305178985449 9.75022022997209e-09 NA NA NA hsa-miR-146b-5p SOS2 1.75587235896724 1.15724631266659e-07 -0.541773165962052 3.38343002773895e-05 miRanda -0.115152479666608 5.46824888444679e-10 NA NA NA hsa-miR-15a-5p SOS2 2.34669284378787 1.69544424500258e-23 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.100823047270651 8.09178891804544e-05 NA NA NA hsa-miR-193a-3p SOS2 1.60460546928078 2.86169793322984e-07 -0.541773165962052 3.38343002773895e-05 PITA;miRanda;miRNATAP -0.115828791088816 4.45409413355469e-09 NA NA NA hsa-miR-199a-5p SOS2 0.592984035153911 0.0674836634175293 -0.541773165962052 3.38343002773895e-05 PITA;miRanda;miRNATAP -0.106315824647688 3.80818848808324e-08 NA NA NA hsa-miR-199b-5p SOS2 0.218704279044827 0.519493319158441 -0.541773165962052 3.38343002773895e-05 PITA;miRanda;miRNATAP -0.110351567625311 2.11664365720639e-09 NA NA NA hsa-miR-21-5p SOS2 2.73773305747971 1.38864982139576e-43 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.17866087041205 3.99766997060001e-10 NA NA NA hsa-miR-424-5p SOS2 1.61930224569578 1.89642549274994e-10 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.10457735471019 1.79360950512032e-05 NA NA NA hsa-miR-454-3p SOS2 2.47234127820054 1.12878018736016e-21 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.106988836200975 7.58489665683655e-06 NA NA NA hsa-miR-493-5p SOS2 0.847772103665986 0.00528678068747754 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.107549440318842 2.05055453955094e-07 NA NA NA hsa-miR-590-3p SOS2 2.59289455139753 1.03200520972022e-21 -0.541773165962052 3.38343002773895e-05 miRanda;mirMAP -0.115775809148697 3.43791025032322e-07 NA NA NA hsa-miR-590-5p SOS2 3.18300989862077 2.06813568597893e-26 -0.541773165962052 3.38343002773895e-05 PITA;miRanda;miRNATAP -0.105807242898967 1.7586879655633e-07 NA NA NA hsa-miR-139-5p SPP1 -1.52606598644743 1.20474151350665e-08 3.18422829338263 7.71504146360324e-09 miRanda -0.39124385273467 8.62801906059466e-05 NA NA NA hsa-miR-335-5p SPP1 1.77247705492746 2.22457658872091e-06 3.18422829338263 7.71504146360324e-09 miRNAWalker2_validate -0.147525764189745 0.0400388771873224 NA NA NA hsa-miR-130b-5p SYK 2.9963110846538 1.98883029416455e-18 -0.135539658170963 0.612831284144568 mirMAP -0.106397988982408 0.00426064698201807 NA NA NA hsa-miR-421 SYK 1.17791565395543 6.78526676976629e-06 -0.135539658170963 0.612831284144568 miRanda -0.151701272172841 0.00203753549510699 NA NA NA hsa-miR-99b-3p SYK 1.62436885280973 8.09988670773273e-10 -0.135539658170963 0.612831284144568 miRNAWalker2_validate -0.227233220412288 1.885196945473e-06 NA NA NA hsa-miR-181b-5p TCL1A 2.49307679431293 3.92829250217627e-20 -1.9437006653245 0.00600008132605253 miRNAWalker2_validate -0.327568851126903 0.00686350531641504 NA NA NA hsa-miR-940 TCL1A 3.21011374578759 2.7923171128495e-14 -1.9437006653245 0.00600008132605253 miRNATAP -0.604162232846713 5.67549364386861e-13 NA NA NA hsa-miR-125a-3p TEK 1.24490295132072 5.26925231010328e-06 -1.75239705645466 2.22611361532503e-08 miRanda -0.141385908337206 0.0117080417856413 NA NA NA hsa-miR-421 TEK 1.17791565395543 6.78526676976629e-06 -1.75239705645466 2.22611361532503e-08 miRanda -0.261528124066448 7.09099724740353e-06 NA NA NA hsa-miR-455-5p TEK 2.2582442061694 1.43472128037398e-13 -1.75239705645466 2.22611361532503e-08 miRanda -0.220574337227575 5.84401907455115e-06 NA NA NA hsa-let-7a-3p THBS1 1.42015538786275 7.03375209382654e-13 -2.1277814514878 2.63898598170147e-08 mirMAP -0.324256229204835 0.000499512291196202 NA NA NA hsa-let-7a-5p THBS1 0.618599506841644 2.76973453058748e-05 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate;TargetScan -0.793931296421232 4.01263206453322e-10 NA NA NA hsa-let-7b-5p THBS1 0.604314269683977 0.00140009936153214 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.3783572455659 0.00015103278303974 NA NA NA hsa-let-7d-5p THBS1 1.33236798905207 1.1741085658466e-13 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.859220357114439 4.03379037942602e-18 NA NA NA hsa-miR-151a-3p THBS1 1.24018761527407 1.08839919675408e-07 -2.1277814514878 2.63898598170147e-08 MirTarget -0.694569328638858 1.06745479684608e-19 NA NA NA hsa-miR-16-1-3p THBS1 2.56983217111073 3.02262181237943e-20 -2.1277814514878 2.63898598170147e-08 MirTarget -0.547933930739432 9.0287268587793e-18 NA NA NA hsa-miR-17-5p THBS1 3.2710598467455 9.93128340539455e-27 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.535410262786805 2.01390645555519e-22 NA NA NA hsa-miR-181a-5p THBS1 2.29556023480783 1.8138457900616e-21 -2.1277814514878 2.63898598170147e-08 mirMAP -0.311799903081761 2.56428301535389e-05 NA NA NA hsa-miR-181b-5p THBS1 2.49307679431293 3.92829250217627e-20 -2.1277814514878 2.63898598170147e-08 mirMAP -0.286545329851077 1.38651496488125e-05 NA NA NA hsa-miR-181c-5p THBS1 1.58587920618301 1.57506918816933e-10 -2.1277814514878 2.63898598170147e-08 mirMAP -0.509013456937225 2.75401083927959e-12 NA NA NA hsa-miR-182-5p THBS1 3.53923166221814 5.07781258121574e-21 -2.1277814514878 2.63898598170147e-08 MirTarget -0.464276709680251 4.8914160255443e-25 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-186-5p THBS1 1.47445398888668 3.0781726595413e-15 -2.1277814514878 2.63898598170147e-08 mirMAP -0.790631830268256 8.0462867743067e-17 NA NA NA hsa-miR-18a-5p THBS1 3.78535678765353 3.72446596213886e-26 -2.1277814514878 2.63898598170147e-08 MirTarget -0.35804586565731 2.12561579001182e-12 NA NA NA hsa-miR-19a-3p THBS1 3.42309334186656 3.02671914353412e-28 -2.1277814514878 2.63898598170147e-08 MirTarget;mirMAP -0.479011511951586 1.31597383903182e-18 NA NA NA hsa-miR-19b-3p THBS1 2.49529833021187 1.57028265846699e-23 -2.1277814514878 2.63898598170147e-08 MirTarget;mirMAP -0.632469943962746 2.39270341905539e-20 NA NA NA hsa-miR-200a-5p THBS1 3.86316681673704 1.81076942093171e-15 -2.1277814514878 2.63898598170147e-08 MirTarget -0.396991686050601 3.54394977146249e-30 NA NA NA hsa-miR-200b-5p THBS1 2.54484902707822 1.59240467582976e-06 -2.1277814514878 2.63898598170147e-08 MirTarget -0.404286942819477 1.05447906162297e-27 NA NA NA hsa-miR-20a-5p THBS1 3.15577933619191 4.19753346442454e-25 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.555674406219999 6.63212782868049e-24 NA NA NA hsa-miR-3065-5p THBS1 2.74629919868982 1.86846589298284e-08 -2.1277814514878 2.63898598170147e-08 MirTarget -0.272591193657042 2.35925406869001e-09 NA NA NA hsa-miR-32-5p THBS1 2.34056473219422 6.24134585974322e-20 -2.1277814514878 2.63898598170147e-08 mirMAP -0.532149898174492 6.38170990221277e-15 NA NA NA hsa-miR-335-3p THBS1 3.08791651139852 5.31309869723517e-12 -2.1277814514878 2.63898598170147e-08 mirMAP -0.184976537215221 5.11650202408596e-06 NA NA NA hsa-miR-33a-3p THBS1 1.72765312072219 1.51784443453521e-07 -2.1277814514878 2.63898598170147e-08 MirTarget;mirMAP -0.543323514403514 5.49591905485477e-20 NA NA NA hsa-miR-375 THBS1 1.13910305294079 0.0512283522214186 -2.1277814514878 2.63898598170147e-08 miRanda -0.150506420398144 2.2392975982835e-06 NA NA NA hsa-miR-421 THBS1 1.17791565395543 6.78526676976629e-06 -2.1277814514878 2.63898598170147e-08 miRanda -0.423737249967144 1.77998923967034e-09 NA NA NA hsa-miR-450b-5p THBS1 1.69244418548325 1.68064054148881e-10 -2.1277814514878 2.63898598170147e-08 MirTarget -0.175596375829618 0.0118513762514108 NA NA NA hsa-miR-491-5p THBS1 0.615770352820862 0.0418295628761654 -2.1277814514878 2.63898598170147e-08 miRanda -0.325347677729002 8.67284344402748e-07 NA NA NA hsa-miR-500a-5p THBS1 1.72110365584658 3.0807246212659e-10 -2.1277814514878 2.63898598170147e-08 mirMAP -0.230571146840421 0.000634888611580494 NA NA NA hsa-miR-576-5p THBS1 2.20467023993664 3.4053475193793e-19 -2.1277814514878 2.63898598170147e-08 mirMAP -0.534982297177329 6.59187971715022e-14 NA NA NA hsa-miR-589-3p THBS1 2.51971841868825 2.39125940264107e-11 -2.1277814514878 2.63898598170147e-08 mirMAP -0.296840513596274 5.92807281377074e-08 NA NA NA hsa-miR-590-3p THBS1 2.59289455139753 1.03200520972022e-21 -2.1277814514878 2.63898598170147e-08 miRanda -0.503581788401113 2.48033554789491e-14 NA NA NA hsa-miR-590-5p THBS1 3.18300989862077 2.06813568597893e-26 -2.1277814514878 2.63898598170147e-08 miRanda;mirMAP -0.527120722441568 1.25825852850212e-19 NA NA NA hsa-miR-629-3p THBS1 2.36570947321815 1.33458201201618e-11 -2.1277814514878 2.63898598170147e-08 MirTarget -0.227068483079105 0.000123952249921696 NA NA NA hsa-miR-664a-3p THBS1 0.634721925861133 0.00520070178640421 -2.1277814514878 2.63898598170147e-08 mirMAP -0.570820389169422 2.01213211719281e-12 NA NA NA hsa-miR-671-5p THBS1 2.97733652243246 1.21148452344738e-23 -2.1277814514878 2.63898598170147e-08 MirTarget -0.50692748391382 1.23943837944331e-16 NA NA NA hsa-miR-7-1-3p THBS1 1.84950311431067 1.25300363397654e-13 -2.1277814514878 2.63898598170147e-08 MirTarget;mirMAP -0.527473744629066 1.61947893119384e-13 NA NA NA hsa-miR-92a-3p THBS1 2.06460102658973 1.44784291084757e-19 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.769477829682195 9.27438286986465e-25 NA NA NA hsa-miR-940 THBS1 3.21011374578759 2.7923171128495e-14 -2.1277814514878 2.63898598170147e-08 MirTarget -0.39529960019763 2.55260567750224e-18 NA NA NA hsa-miR-944 THBS1 2.91186649218281 1.31574753528144e-06 -2.1277814514878 2.63898598170147e-08 MirTarget;PITA -0.199538618837297 1.63491480056503e-10 NA NA NA hsa-miR-98-5p THBS1 1.11154309866014 1.24143909012085e-08 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.724389356283188 5.99048052515149e-15 NA NA NA hsa-miR-106a-5p THBS2 2.48882002962836 1.99757727374521e-12 -0.819009338080235 0.127001426128545 MirTarget -0.45330116032702 9.62830193644936e-11 NA NA NA hsa-miR-106b-5p THBS2 2.46782146831112 1.36171495805632e-23 -0.819009338080235 0.127001426128545 MirTarget -0.72193483715216 1.20112772084899e-13 NA NA NA hsa-miR-16-2-3p THBS2 2.31623086727196 4.29838149388188e-20 -0.819009338080235 0.127001426128545 mirMAP -0.579127576562822 2.3897295143244e-09 NA NA NA hsa-miR-17-5p THBS2 3.2710598467455 9.93128340539455e-27 -0.819009338080235 0.127001426128545 MirTarget;TargetScan -0.513157286321094 5.2287894266298e-11 NA NA NA hsa-miR-182-5p THBS2 3.53923166221814 5.07781258121574e-21 -0.819009338080235 0.127001426128545 MirTarget;miRNATAP -0.378179542663928 4.95986922868172e-09 NA NA NA hsa-miR-20a-5p THBS2 3.15577933619191 4.19753346442454e-25 -0.819009338080235 0.127001426128545 MirTarget -0.524692617570923 2.5011034764088e-11 NA NA NA hsa-miR-20b-5p THBS2 2.07706563022469 1.10107236083433e-05 -0.819009338080235 0.127001426128545 MirTarget -0.34463233280832 9.76692709595905e-11 NA NA NA hsa-miR-29b-3p THBS2 1.65828197923813 1.02676780888141e-09 -0.819009338080235 0.127001426128545 MirTarget -0.207168863270378 0.027846713924368 NA NA NA hsa-miR-29c-3p THBS2 -0.00968972577705429 0.97099586346872 -0.819009338080235 0.127001426128545 MirTarget -0.227132522036715 0.0206349380901597 NA NA NA hsa-miR-32-3p THBS2 2.02436999565685 5.94091197945307e-09 -0.819009338080235 0.127001426128545 miRNATAP -0.439958956826284 1.04187343353676e-07 NA NA NA hsa-miR-320a THBS2 0.438165828017084 0.0390159073347133 -0.819009338080235 0.127001426128545 mirMAP -0.738913348853994 1.08030683289646e-09 NA NA NA hsa-miR-320b THBS2 1.55692969039548 1.41071034251915e-08 -0.819009338080235 0.127001426128545 mirMAP -0.576382788700426 3.09497468053932e-10 NA NA NA hsa-miR-3614-5p THBS2 2.17736331059655 2.19144831318484e-08 -0.819009338080235 0.127001426128545 miRNATAP -0.172742549544423 0.011117304822606 NA NA NA hsa-miR-582-3p THBS2 0.00876844181512659 0.977126166214707 -0.819009338080235 0.127001426128545 miRNATAP -0.362802196964235 1.83546472971205e-05 NA NA NA hsa-miR-590-3p THBS2 2.59289455139753 1.03200520972022e-21 -0.819009338080235 0.127001426128545 miRanda;mirMAP -0.415992971199857 8.15429265241593e-06 NA NA NA hsa-miR-590-5p THBS2 3.18300989862077 2.06813568597893e-26 -0.819009338080235 0.127001426128545 miRanda -0.373930357407742 7.01724345875243e-06 NA NA NA hsa-miR-598-3p THBS2 0.760968346755936 0.027870939187342 -0.819009338080235 0.127001426128545 MirTarget -0.585284197674181 6.99576512493496e-16 NA NA NA hsa-miR-7-1-3p THBS2 1.84950311431067 1.25300363397654e-13 -0.819009338080235 0.127001426128545 MirTarget;mirMAP -0.465723609777495 3.68568678198485e-06 NA NA NA hsa-miR-9-5p THBS2 1.02304182473283 0.042901377604859 -0.819009338080235 0.127001426128545 miRNATAP -0.139117281625275 0.00664593677825042 NA NA NA hsa-miR-93-5p THBS2 3.03961860136032 1.11672209617395e-24 -0.819009338080235 0.127001426128545 MirTarget -0.631952471595904 3.23254182973957e-15 NA NA NA hsa-miR-96-5p THBS2 4.89433085814374 1.92000659886961e-31 -0.819009338080235 0.127001426128545 TargetScan;miRNATAP -0.333472922491884 8.9160648870827e-09 NA NA NA hsa-miR-423-5p THBS3 0.963563145758616 9.86109015204915e-07 -0.433511810214603 0.0373666205114857 PITA;miRNATAP -0.101150323733681 0.0481432565006239 NA NA NA hsa-miR-550a-5p THBS3 2.11025227932763 6.94489556637146e-12 -0.433511810214603 0.0373666205114857 MirTarget -0.131739842044515 3.61387503138023e-05 NA NA NA hsa-miR-320a THBS4 0.438165828017084 0.0390159073347133 -1.61386852407018 0.022417160956919 miRanda -0.961924839649886 1.83285453703857e-09 NA NA NA hsa-miR-320b THBS4 1.55692969039548 1.41071034251915e-08 -1.61386852407018 0.022417160956919 miRanda -0.79406795149706 4.51318828279766e-11 NA NA NA hsa-miR-106b-5p TLR2 2.46782146831112 1.36171495805632e-23 0.646937183771412 0.0617661425490257 miRNAWalker2_validate -0.318657306790343 6.25478557127756e-07 NA NA NA hsa-miR-335-5p TLR2 1.77247705492746 2.22457658872091e-06 0.646937183771412 0.0617661425490257 miRNAWalker2_validate -0.224767434451374 2.77578362310241e-07 NA NA NA hsa-miR-107 TLR4 1.30977326593435 1.30372468603965e-11 -1.18001070363141 0.00022764532171335 miRanda -0.266111020383369 0.000784210963248991 NA NA NA hsa-miR-17-5p TLR4 3.2710598467455 9.93128340539455e-27 -1.18001070363141 0.00022764532171335 TargetScan -0.231144030542026 1.10680359082664e-06 NA NA NA hsa-miR-331-5p TLR4 2.17414714166315 1.54547681391888e-18 -1.18001070363141 0.00022764532171335 MirTarget -0.335975742354478 4.67066323283181e-08 NA NA NA hsa-miR-34c-5p TLR4 2.07190852984647 7.35776320806257e-08 -1.18001070363141 0.00022764532171335 miRanda -0.120358100377601 0.00467075248681912 NA NA NA hsa-miR-369-3p TLR4 0.946781510019564 0.00134850306966842 -1.18001070363141 0.00022764532171335 miRNATAP -0.135516315806433 0.0102986347951374 NA NA NA hsa-miR-421 TLR4 1.17791565395543 6.78526676976629e-06 -1.18001070363141 0.00022764532171335 miRanda -0.25088847731826 2.09002972283148e-05 NA NA NA hsa-miR-590-3p TLR4 2.59289455139753 1.03200520972022e-21 -1.18001070363141 0.00022764532171335 miRanda;mirMAP -0.266448103258332 1.84692615238438e-06 NA NA NA hsa-miR-590-5p TLR4 3.18300989862077 2.06813568597893e-26 -1.18001070363141 0.00022764532171335 miRanda -0.255965711791364 2.68592698992246e-07 NA NA NA hsa-miR-7-1-3p TLR4 1.84950311431067 1.25300363397654e-13 -1.18001070363141 0.00022764532171335 mirMAP -0.227616264646714 0.000174585300588628 NA NA NA hsa-miR-7-5p TLR4 2.28980165299999 1.5131097560452e-07 -1.18001070363141 0.00022764532171335 MirTarget -0.181598493774332 1.35114450592002e-06 24004462 Our recent evidence showed that Toll like receptor 9 TLR9 signaling could enhance the growth and metastatic potential of human lung cancer cells through repressing microRNA-7 miR-7 expression lung cancer hsa-miR-944 TLR4 2.91186649218281 1.31574753528144e-06 -1.18001070363141 0.00022764532171335 miRNATAP -0.137790002027273 1.23261356204859e-07 NA NA NA hsa-miR-126-5p TNC 0.895338176458417 2.33372756450713e-05 -1.22885204293992 0.0251580253603685 miRNATAP -0.357984093331907 0.00438147708100397 NA NA NA hsa-miR-330-3p TNC 0.876747334239085 0.00073709016089703 -1.22885204293992 0.0251580253603685 MirTarget -0.822718297482533 7.76964944968044e-17 NA NA NA hsa-miR-330-5p TNC 1.15100069700871 4.85551805046014e-07 -1.22885204293992 0.0251580253603685 MirTarget;miRanda;miRNATAP -0.570830378295863 6.0234172906234e-07 NA NA NA hsa-miR-335-5p TNC 1.77247705492746 2.22457658872091e-06 -1.22885204293992 0.0251580253603685 miRNAWalker2_validate;miRTarBase -0.419460226623402 1.20209798800426e-09 NA NA NA hsa-miR-425-5p TNC 3.07071373939774 4.02947460586085e-25 -1.22885204293992 0.0251580253603685 MirTarget -0.77347195632064 8.04287310910487e-22 NA NA NA hsa-miR-501-5p TNC 1.93654809410041 1.3779381780759e-10 -1.22885204293992 0.0251580253603685 miRNATAP -0.424449447117241 1.48148046827061e-06 NA NA NA hsa-miR-505-5p TNC 1.89243395287645 9.82003586561819e-12 -1.22885204293992 0.0251580253603685 MirTarget -0.701253157329603 1.22331831661449e-14 NA NA NA hsa-miR-590-3p TNC 2.59289455139753 1.03200520972022e-21 -1.22885204293992 0.0251580253603685 miRanda -0.380188102198532 7.16384228011859e-05 NA NA NA hsa-miR-944 TNN 2.91186649218281 1.31574753528144e-06 0.356620669973133 0.507811811754825 miRNATAP -0.187916539397409 1.75174779474181e-05 NA NA NA hsa-miR-1301-3p TNXB 2.54959518791507 5.26618591274892e-18 -5.33950719719598 1.13608514104698e-23 miRNAWalker2_validate -0.811544767747683 9.14250138091737e-22 NA NA NA hsa-miR-30c-5p TNXB 0.778774633108 0.000285599212429136 -5.33950719719598 1.13608514104698e-23 mirMAP -0.313759975175537 0.0138310454063894 NA NA NA hsa-miR-3607-3p TNXB 2.68532138541128 5.66716351955047e-14 -5.33950719719598 1.13608514104698e-23 miRNATAP -0.537563552476966 3.87969838999221e-13 NA NA NA hsa-miR-221-3p TP53 0.451556679024397 0.0909808299917811 0.17313275059387 0.48779406985331 miRNAWalker2_validate -0.115825211031354 0.0105671893909646 20880178;24324033 Circulating miR 221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression; The correlation between miR-221 levels and protein levels of p53 CEA ER and PR clinicopathological features or overall survival was analyzed; The immunohistochemistry analysis demonstrates a significant correlation between plasma miR-221 level and p53 expression; The direct amplification of plasma miR-221 can be used as a potential noninvasive molecular marker for diagnosis and prognosis of CRC and is correlated with p53 expression;Interestingly miR-221 can activate the p53/mdm2 axis by inhibiting MDM2 and in turn p53 activation contributes to miR-221 enhanced expression; Moreover by modulating the p53 axis miR-221 impacts cell-cycle progression and apoptotic response to doxorubicin in hepatocellular carcinoma-derived cell lines; These data were confirmed in clinical specimens of hepatocellular carcinoma in which elevated miR-221 expression was associated with the simultaneous presence of wild-type p53 and DNA hypomethylation poor survival;worse prognosis;progression;drug resistance colorectal cancer;liver cancer hsa-miR-222-3p TP53 0.851783756239071 0.00266783568486918 0.17313275059387 0.48779406985331 miRNAWalker2_validate -0.116904656132339 0.00589565055970469 NA NA NA hsa-miR-1-3p VEGFA -3.48370702447685 1.98579484008516e-13 0.471653090802802 0.0989904385682923 MirTarget -0.202978528176548 1.57292170658149e-13 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-133a-3p VEGFA -3.38501431117712 1.32336729742128e-13 0.471653090802802 0.0989904385682923 miRNAWalker2_validate -0.190996958246616 2.70660605752725e-11 NA NA NA hsa-miR-134-5p VEGFA 0.141163006984518 0.655334296084178 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase;MirTarget -0.180227374251871 3.58435465670397e-05 NA NA NA hsa-miR-145-5p VEGFA -1.55259331973517 9.97889123247165e-07 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase -0.277645238248207 4.72205041776188e-11 24966896;24781864;22472569 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically ;metastasis; bladder cancer;thyroid cancer;sarcoma hsa-miR-150-5p VEGFA -0.105827294491332 0.799351458244375 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase -0.164137084593398 6.0374913950269e-07 NA NA NA hsa-miR-195-5p VEGFA -1.44753678070504 8.70594292149271e-09 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase;MirTarget -0.21863878149299 5.11037236008283e-05 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199a-5p VEGFA 0.592984035153911 0.0674836634175293 0.471653090802802 0.0989904385682923 miRanda;miRNATAP -0.205612739501636 1.1489897892283e-06 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA 0.218704279044827 0.519493319158441 0.471653090802802 0.0989904385682923 miRanda -0.175899050515122 1.43171320791549e-05 NA NA NA hsa-miR-29a-3p VEGFA -0.35074463683376 0.161238718982428 0.471653090802802 0.0989904385682923 MirTarget -0.313847513848792 9.68544057650496e-09 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-342-3p VEGFA 1.49115144672245 1.43879249744621e-07 0.471653090802802 0.0989904385682923 miRanda;miRNATAP -0.166390639835536 0.000539599594707828 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-374b-5p VEGFA 0.0654362503857184 0.722673188879465 0.471653090802802 0.0989904385682923 MirTarget -0.254824056474554 0.000792850845311603 NA NA NA hsa-miR-655-3p VEGFA 0.485339318272148 0.137014658258732 0.471653090802802 0.0989904385682923 MirTarget -0.164823030617487 0.000126415331270495 NA NA NA hsa-miR-128-3p VEGFC 1.63756041666078 6.79626586407187e-14 -0.457873556695705 0.178610332401836 miRNAWalker2_validate;MirTarget -0.377058704312277 2.16798927147771e-07 26722309;25001183 miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells;Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways metastasis; bladder cancer;lung squamous cell cancer hsa-miR-27b-3p VEGFC 0.196007704287769 0.295630157035388 -0.457873556695705 0.178610332401836 MirTarget -0.184894953706514 0.038219701457811 23593282 We identified vascular endothelial growth factor C VEGFC as a novel target gene of miR-27b and determined that miR-27b functioned as an inhibitor of tumor progression and angiogenesis through targeting VEGFC in CRC; In summary an anti-tumor role for miR-27b and its novel target VEGFC in vivo could lead to tumor necrosis and provide a rationale for developing miR-27b as a therapeutic agent progression colorectal cancer hsa-miR-26b-5p VTN 0.885393662798425 3.2116297961629e-06 -1.4402847289379 0.0149163923385935 miRNAWalker2_validate -0.666673342207355 8.7570867643941e-06 NA NA NA hsa-miR-335-5p VTN 1.77247705492746 2.22457658872091e-06 -1.4402847289379 0.0149163923385935 miRNAWalker2_validate -0.224748222597798 0.00297072733558683 NA NA NA hsa-miR-15a-5p VWF 2.34669284378787 1.69544424500258e-23 -1.23052279587985 1.77743460736343e-06 mirMAP -0.229162553614731 6.0157159465609e-06 NA NA NA hsa-miR-15b-5p VWF 1.57112623124278 9.14247846750597e-13 -1.23052279587985 1.77743460736343e-06 mirMAP -0.361179620811517 5.00899941400228e-11 NA NA NA hsa-miR-16-5p VWF 1.75824877145857 1.68592440033108e-16 -1.23052279587985 1.77743460736343e-06 mirMAP -0.331768492300045 4.17025386117188e-09 NA NA NA hsa-miR-424-5p VWF 1.61930224569578 1.89642549274994e-10 -1.23052279587985 1.77743460736343e-06 mirMAP -0.2039965005753 2.52345832163618e-05 NA NA NA hsa-miR-429 VWF 4.48815175680773 2.44117492218206e-17 -1.23052279587985 1.77743460736343e-06 miRNATAP -0.157661538344673 1.35338317180273e-12 NA NA NA hsa-miR-26a-5p YWHAE 0.0464832722967259 0.752628386912329 0.514491612368612 0.000180862815548893 miRNAWalker2_validate;miRNATAP -0.174289033994773 0.000159844329938043 NA NA NA hsa-miR-181c-5p YWHAG 1.58587920618301 1.57506918816933e-10 0.156220759818473 0.240477359976782 MirTarget;miRNATAP -0.107876701640243 1.92571385553603e-05 NA NA NA hsa-miR-23b-3p YWHAG -0.251132426825047 0.150200321210792 0.156220759818473 0.240477359976782 MirTarget;miRNATAP -0.117341634709916 0.00162529518912031 NA NA NA hsa-miR-30b-5p YWHAG 0.800822374912712 0.000133601914525413 0.156220759818473 0.240477359976782 miRNATAP -0.132163142680483 1.39361681058969e-05 NA NA NA hsa-miR-30c-5p YWHAG 0.778774633108 0.000285599212429136 0.156220759818473 0.240477359976782 miRNATAP -0.154812531241318 1.64179950979699e-07 NA NA NA hsa-miR-30d-5p YWHAG 0.675423997639582 0.00270618816039773 0.156220759818473 0.240477359976782 miRNATAP -0.132575862878577 2.82953377535704e-06 NA NA NA hsa-miR-30e-5p YWHAG 1.23904909539663 1.35561917122157e-09 0.156220759818473 0.240477359976782 miRNATAP -0.121468680568388 8.32409315658241e-05 NA NA NA hsa-miR-320a YWHAG 0.438165828017084 0.0390159073347133 0.156220759818473 0.240477359976782 PITA;miRanda;miRNATAP -0.100995313053263 0.000877783562361283 NA NA NA hsa-miR-103a-3p YWHAH 1.44083190496858 1.53799939616416e-13 -0.039384739798634 0.787929142314944 miRNAWalker2_validate;MirTarget;miRNATAP -0.161531751525804 4.29697423677565e-06 NA NA NA hsa-miR-107 YWHAH 1.30977326593435 1.30372468603965e-11 -0.039384739798634 0.787929142314944 MirTarget;PITA;miRanda;miRNATAP -0.102725815874759 0.0042174879223718 NA NA NA hsa-miR-28-5p YWHAH 0.230152919654905 0.0742909586754846 -0.039384739798634 0.787929142314944 PITA;miRanda -0.2331357688511 3.2675565751886e-05 NA NA NA hsa-miR-320a YWHAH 0.438165828017084 0.0390159073347133 -0.039384739798634 0.787929142314944 MirTarget;PITA;miRanda -0.222237517506915 1.10194526758971e-11 NA NA NA hsa-miR-330-3p YWHAH 0.876747334239085 0.00073709016089703 -0.039384739798634 0.787929142314944 MirTarget;PITA;miRNATAP -0.16424153759537 6.98871148996655e-10 NA NA NA hsa-miR-361-5p YWHAH 0.971859117235239 5.30236555707088e-09 -0.039384739798634 0.787929142314944 miRanda -0.219428557867208 1.49722216074945e-07 NA NA NA hsa-miR-320a YWHAQ 0.438165828017084 0.0390159073347133 0.144077300408211 0.350876471829226 MirTarget;PITA;miRanda;miRNATAP -0.167079673898302 1.83255873389778e-06 NA NA NA hsa-miR-28-5p YWHAZ 0.230152919654905 0.0742909586754846 0.309265826104513 0.0711240023820104 PITA;miRanda;miRNATAP -0.131980512724442 0.0468804731221123 NA NA NA hsa-miR-664a-3p YWHAZ 0.634721925861133 0.00520070178640421 0.309265826104513 0.0711240023820104 mirMAP -0.133473662727781 0.000250895262565301 NA NA NA