miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-3p AKT2 0.239865279324672 0.00721479815526816 -0.340477996057433 3.62402949162022e-08 MirTarget -0.103250394013056 0.00819845290941259 NA NA NA hsa-miR-140-5p AKT2 0.504309496243674 3.09884038729031e-11 -0.340477996057433 3.62402949162022e-08 mirMAP -0.257894167615696 4.25294111137846e-09 NA NA NA hsa-miR-193a-3p AKT2 0.849206638484406 3.68101781083335e-14 -0.340477996057433 3.62402949162022e-08 miRanda -0.1602336102543 4.66296866332011e-08 NA NA NA hsa-miR-1976 AKT2 0.343475600930938 0.000360243844871748 -0.340477996057433 3.62402949162022e-08 miRNATAP -0.114100456416688 0.00148676672535644 NA NA NA hsa-miR-21-5p AKT2 2.51462371613332 3.30620591950316e-66 -0.340477996057433 3.62402949162022e-08 miRNAWalker2_validate -0.116002520060245 7.24256492760299e-10 NA NA NA hsa-miR-2355-5p AKT2 1.57515081110162 3.54962327490702e-48 -0.340477996057433 3.62402949162022e-08 mirMAP -0.158007486287123 5.63512797747714e-09 NA NA NA hsa-miR-24-3p AKT2 0.173813044685099 0.00565259443420961 -0.340477996057433 3.62402949162022e-08 mirMAP -0.145738275793208 0.0095430051404417 NA NA NA hsa-miR-330-5p AKT2 1.44960468659754 2.12131210588035e-45 -0.340477996057433 3.62402949162022e-08 miRanda -0.199850402161812 2.39463482226386e-12 NA NA NA hsa-miR-338-3p AKT2 0.906250377628867 2.76970900371139e-15 -0.340477996057433 3.62402949162022e-08 mirMAP -0.160942202850334 1.55482491354725e-08 NA NA NA hsa-miR-342-3p AKT2 1.4124432570595 1.07208971556131e-28 -0.340477996057433 3.62402949162022e-08 mirMAP -0.193694719446483 5.5338386148732e-16 NA NA NA hsa-miR-423-3p AKT2 0.460506077888547 3.44680149368459e-09 -0.340477996057433 3.62402949162022e-08 miRNAWalker2_validate -0.134093002116074 0.00224236224837297 NA NA NA hsa-miR-106b-5p AKT3 1.07509411417907 2.11739194181878e-36 -0.243988630870274 0.0117503955413685 miRNATAP -0.362551297020254 3.77551886386752e-11 NA NA NA hsa-miR-107 AKT3 0.140046250553248 0.0943611632552367 -0.243988630870274 0.0117503955413685 PITA;miRanda -0.284787420850406 8.53745778311515e-06 NA NA NA hsa-miR-146b-5p AKT3 1.40714170253819 2.9559871816487e-12 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate -0.106480044558668 2.77668665683102e-05 NA NA NA hsa-miR-15a-5p AKT3 1.42663930007845 1.36006952074963e-57 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate;miRTarBase;miRNATAP -0.209553352701426 2.74861510149098e-05 NA NA NA hsa-miR-15b-5p AKT3 0.773001494057531 1.71784656078957e-16 -0.243988630870274 0.0117503955413685 miRNATAP -0.179137071242714 0.00102312999530003 NA NA NA hsa-miR-16-5p AKT3 0.934012514027655 4.85417898318515e-24 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate;miRTarBase;miRNATAP -0.174740148583929 0.00122158424330689 NA NA NA hsa-miR-17-3p AKT3 0.723795600017259 5.90151677164931e-18 -0.243988630870274 0.0117503955413685 miRNATAP -0.202376849787589 0.00088737719875351 NA NA NA hsa-miR-17-5p AKT3 0.494260110870015 3.8348005261e-09 -0.243988630870274 0.0117503955413685 TargetScan;miRNATAP -0.190824149294487 0.00237163147001594 NA NA NA hsa-miR-22-3p AKT3 0.198460552200729 0.00761005672059428 -0.243988630870274 0.0117503955413685 miRNATAP -0.407589872687642 1.12041867452881e-08 NA NA NA hsa-miR-29a-3p AKT3 -0.431613225927952 4.10166815070288e-08 -0.243988630870274 0.0117503955413685 miRNATAP -0.244491422189309 0.000269689815704259 NA NA NA hsa-miR-29b-3p AKT3 -0.228125979913806 0.0271621721891603 -0.243988630870274 0.0117503955413685 miRNATAP -0.247981734385757 1.40066355236384e-06 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-374b-5p AKT3 0.0804104684417872 0.365593963035077 -0.243988630870274 0.0117503955413685 mirMAP -0.250536892298211 3.33662467499594e-05 NA NA NA hsa-miR-421 AKT3 0.313155739887734 0.020433534776003 -0.243988630870274 0.0117503955413685 miRanda;mirMAP -0.144627984206661 0.000385343212972084 NA NA NA hsa-miR-542-3p AKT3 0.431147917094433 0.000254981247606435 -0.243988630870274 0.0117503955413685 miRanda -0.173551255334696 0.000111564350795738 NA NA NA hsa-miR-616-5p AKT3 0.913426384742148 3.78418389333709e-09 -0.243988630870274 0.0117503955413685 mirMAP -0.172749202880246 3.16635692442533e-07 NA NA NA hsa-miR-93-5p AKT3 1.37365940377595 2.37567548683245e-46 -0.243988630870274 0.0117503955413685 miRNATAP -0.172188027294336 0.000349761294454902 NA NA NA hsa-miR-146b-5p ANGPT1 1.40714170253819 2.9559871816487e-12 -0.985552064534845 1.94537731705344e-10 miRanda -0.220243977048136 1.0451286572533e-07 NA NA NA hsa-miR-590-3p ANGPT1 1.13702599385212 3.53435739887793e-22 -0.985552064534845 1.94537731705344e-10 PITA;miRanda;mirMAP -0.427703951979757 4.61649825016446e-10 NA NA NA hsa-miR-125a-5p ANGPT2 -0.561874059994802 7.3931856356891e-13 3.2279729131303 1.51342644964021e-50 miRanda -0.591277292988033 0.000656123320213166 NA NA NA hsa-miR-135a-5p ANGPT2 -2.13422485001223 6.29449029671498e-14 3.2279729131303 1.51342644964021e-50 MirTarget -0.282490332765068 2.39173511082776e-09 NA NA NA hsa-miR-335-3p ANGPT2 -1.36498175550207 6.84287752180534e-13 3.2279729131303 1.51342644964021e-50 mirMAP -0.535010814152484 4.07158596361409e-15 NA NA NA hsa-miR-381-3p ANGPT2 -0.674906433524392 0.000234722307243307 3.2279729131303 1.51342644964021e-50 mirMAP -0.333901097103082 9.96762738841714e-06 NA NA NA hsa-miR-429 ANGPT2 -2.16569233119434 2.66862243626443e-37 3.2279729131303 1.51342644964021e-50 miRanda -0.720876199916154 1.69585500076757e-26 NA NA NA hsa-miR-539-5p ANGPT2 -1.44841597031461 8.25650852878567e-11 3.2279729131303 1.51342644964021e-50 mirMAP -0.354280479023757 7.58513939866313e-09 NA NA NA hsa-miR-577 ANGPT2 -1.48881999472397 7.03080165111147e-10 3.2279729131303 1.51342644964021e-50 mirMAP -0.20703264362078 0.000237923717522693 NA NA NA hsa-miR-744-3p ANGPT2 -0.268747126270442 0.0255846712882831 3.2279729131303 1.51342644964021e-50 MirTarget -0.303019314922211 0.00923616581326206 NA NA NA hsa-miR-9-5p ANGPT2 -2.23538606210968 1.28143998950751e-12 3.2279729131303 1.51342644964021e-50 MirTarget -0.155756599777652 0.000249620141111064 NA NA NA hsa-let-7a-3p ATF2 0.0677487960013088 0.460458477653989 -0.430671917958647 1.95972009533608e-05 MirTarget;mirMAP;miRNATAP -0.258206576796938 2.61705263820418e-05 NA NA NA hsa-let-7f-1-3p ATF2 0.477913872379336 4.46669616865068e-05 -0.430671917958647 1.95972009533608e-05 MirTarget;mirMAP -0.17834629067546 0.000534605693773569 NA NA NA hsa-miR-140-3p ATF2 0.989350547007025 6.14964028267239e-25 -0.430671917958647 1.95972009533608e-05 MirTarget;PITA;miRNATAP -0.164416457351873 0.00257839953228269 NA NA NA hsa-miR-15a-5p ATF2 1.42663930007845 1.36006952074963e-57 -0.430671917958647 1.95972009533608e-05 miRNAWalker2_validate -0.233760076403299 8.31704154782812e-06 NA NA NA hsa-miR-181a-5p ATF2 1.11111114875339 3.97880443756442e-29 -0.430671917958647 1.95972009533608e-05 mirMAP;miRNATAP -0.177371113322549 0.00063116587052713 NA NA NA hsa-miR-181b-5p ATF2 1.49054296272357 3.69051660739368e-41 -0.430671917958647 1.95972009533608e-05 mirMAP;miRNATAP -0.187569275587416 2.3264034331938e-05 NA NA NA hsa-miR-19b-3p ATF2 0.195940928879427 0.0300512922542325 -0.430671917958647 1.95972009533608e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.171622349992384 0.0062154989166173 NA NA NA hsa-miR-21-5p ATF2 2.51462371613332 3.30620591950316e-66 -0.430671917958647 1.95972009533608e-05 miRNAWalker2_validate -0.146377158546288 2.19887514179696e-06 NA NA NA hsa-miR-221-3p ATF2 0.337895669520713 0.0136448974691037 -0.430671917958647 1.95972009533608e-05 MirTarget -0.20430513138651 4.43575326168723e-07 NA NA NA hsa-miR-590-3p ATF2 1.13702599385212 3.53435739887793e-22 -0.430671917958647 1.95972009533608e-05 MirTarget;miRanda;mirMAP;miRNATAP -0.133368731251531 0.00299498751306343 NA NA NA hsa-miR-125b-5p BCL2 -0.825456421494266 2.13029877878434e-15 0.611723089464483 2.23843978894366e-08 miRNAWalker2_validate;miRTarBase -0.18771702327675 0.000938494359228133 24643683;21823019;20460378;26744308 Moreover we demonstrated that the pro-apoptotic Bcl-2 antagonist killer 1 Bak1 was a direct target of miR-125b;miR 125b confers resistance of ovarian cancer cells to cisplatin by targeting pro apoptotic Bcl 2 antagonist killer 1;Moreover we demonstrated that the pro-apoptotic Bcl-2 antagonist killer 1 Bak1 is a direct target of miR-125b;Our data also verified that Bcl-2 is the target of miR-125b; Meanwhile we showed that Bcl-2 was inversely correlated with miR-125b in osteosarcoma tissues; More importantly we proved that miR-125b increased the chemosensitivity of osteosarcoma cell lines to cisplatin by targeting Bcl-2 ;drug resistance;; glioblastoma;ovarian cancer;breast cancer;sarcoma hsa-miR-136-5p BCL2 -1.67696564080585 1.99625416234538e-18 0.611723089464483 2.23843978894366e-08 miRNAWalker2_validate;miRTarBase -0.146439820440682 1.14288049875745e-06 NA NA NA hsa-miR-182-5p BCL2 -0.608710746044567 0.0025264935278104 0.611723089464483 2.23843978894366e-08 miRNAWalker2_validate;miRTarBase;mirMAP -0.177081265177555 2.6443917985073e-09 23936432;26870290 Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR 182 and p21; Bcl2 and p21 were identified to be potential target genes of miR-182 in PC3 cells;The expression levels of B-cell lymphoma-2 Bcl-2 and microRNA-182 miR-182 were detected using western blot analysis and quantitative reverse transcription-polymerase chain reaction respectively; Mangiferin treatment was also able to significantly reduce Bcl-2 expression levels and enhance miR-182 expression in PC3 cells; Finally it was observed that mangiferin inhibited proliferation and induced apoptosis in PC3 human prostate cancer cells and this effect was correlated with downregulation of Bcl-2 and upregulation of miR-182 ; prostate cancer;B cell lymphoma hsa-miR-29a-3p BCL2 -0.431613225927952 4.10166815070288e-08 0.611723089464483 2.23843978894366e-08 miRNAWalker2_validate;miRTarBase -0.567223045416415 3.24510575317255e-14 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29a-5p BCL2 -0.519003718107105 1.03351148282116e-06 0.611723089464483 2.23843978894366e-08 mirMAP -0.259237667771286 4.98631789999366e-06 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29b-3p BCL2 -0.228125979913806 0.0271621721891603 0.611723089464483 2.23843978894366e-08 miRNAWalker2_validate;miRTarBase -0.330351798843962 1.96048711047023e-08 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-335-3p BCL2 -1.36498175550207 6.84287752180534e-13 0.611723089464483 2.23843978894366e-08 mirMAP -0.215422651970675 1.11346348504947e-12 NA NA NA hsa-miR-33a-5p BCL2 -1.59840463890997 1.13487952314403e-18 0.611723089464483 2.23843978894366e-08 mirMAP -0.157287327649195 8.12118407365628e-07 NA NA NA hsa-miR-365a-3p BCL2 0.80809616164259 2.36039522526e-12 0.611723089464483 2.23843978894366e-08 miRNAWalker2_validate;miRTarBase -0.227996300541644 8.90997818574674e-06 NA NA NA hsa-miR-375 BCL2 -1.46468479447701 9.20596529469647e-07 0.611723089464483 2.23843978894366e-08 miRNAWalker2_validate -0.102079936703486 3.24244153934503e-07 26381132;26697569;25613180 The levels of miR-375 Bax and Bcl-2 protein expression in treated cells were determined by Western blot and RT-PCR; Moreover compared to control group the expression of Bcl-2 and miR-375 decreases with formononetin in the U2OS cells while Bax increases;Exosome Carried microRNA 375 Inhibits Cell Progression and Dissemination via Bcl 2 Blocking in Colon Cancer; RT-PCR for Bcl-2 expression showed that Bcl-2 is down-regulated for miR-375 inhibitor and up-regulated for the miR-375 mimic a result confirmed by Western blotting; The present study brings to the forefront new data that suggest miR-375 as a new player in controlling the pathways responsible for inhibiting the natural history of CRC tumor cells via the Bcl-2 pathway;mRNA levels of ERα Bcl-2 and miR-375 were quantified using real-time polymerase chain reaction; After treatment with biochanin A ERα miR-375 and Bcl-2 expression was significantly upregulated ;progression; sarcoma;colon cancer;breast cancer hsa-miR-409-3p BCL2 -0.292481246887274 0.114186058216271 0.611723089464483 2.23843978894366e-08 mirMAP -0.139981660731413 2.67838476038654e-05 NA NA NA hsa-miR-582-5p BCL2 -0.323404837478908 0.0786820871592677 0.611723089464483 2.23843978894366e-08 PITA -0.140583753589503 2.48245800619386e-05 NA NA NA hsa-miR-96-5p BCL2 -1.00223771166604 3.91564621567028e-06 0.611723089464483 2.23843978894366e-08 miRNAWalker2_validate;TargetScan -0.189419757848449 1.35177733054416e-11 NA NA NA hsa-miR-505-5p BCL2L1 -0.109332726329313 0.346400159841743 0.056672670469081 0.380838191246795 miRNATAP -0.108957481398792 0.000366888756795515 NA NA NA hsa-miR-101-3p BCL2L11 0.683973909682285 2.88573524246948e-15 -0.280076657339514 0.000362193641126999 miRNATAP -0.167533535099558 0.000526399405063189 NA NA NA hsa-miR-106b-5p BCL2L11 1.07509411417907 2.11739194181878e-36 -0.280076657339514 0.000362193641126999 miRTarBase;miRNATAP -0.224333681827675 7.26656607031853e-07 NA NA NA hsa-miR-125b-2-3p BCL2L11 -0.1289424145005 0.259595722065455 -0.280076657339514 0.000362193641126999 mirMAP -0.105001240413289 0.00607408472270336 NA NA NA hsa-miR-181a-5p BCL2L11 1.11111114875339 3.97880443756442e-29 -0.280076657339514 0.000362193641126999 miRNAWalker2_validate;miRTarBase;miRNATAP -0.191392060933305 1.54265651786458e-06 23241956;20841506 Mechanistically inactivation of miR-181a elevated the expression of the proapoptotic molecule Bim which sensitized metastatic cells to anoikis;Furthermore we found that cell adhesion-up-regulated miR-181a contributes to FDC-mediated cell survival through Bim down-regulation implicating miR-181a as an upstream effector of the Bim-apoptosis signaling pathway; miR-181a inhibition and Bim upregulation significantly suppressed FDC-mediated protection against apoptosis in lymphoma cell lines and primary lymphoma cells ;poor survival breast cancer;lymphoma hsa-miR-181b-5p BCL2L11 1.49054296272357 3.69051660739368e-41 -0.280076657339514 0.000362193641126999 miRNATAP -0.161898175014918 2.20711965769825e-06 26572075 MiR 181b promotes chemoresistance in breast cancer by regulating Bim expression; Mechanistic studies demonstrated that the Bim gene an essential initiator of apoptosis was inhibited by miR-181b overexpression; Importantly we demonstrated that miR-181b inhibitors increased the level of Bim in the T-47D-R cells resulting in the loss of mitochondrial membrane potential MMP and the activation of caspases caused by DOX drug resistance breast cancer hsa-miR-24-3p BCL2L11 0.173813044685099 0.00565259443420961 -0.280076657339514 0.000362193641126999 miRNAWalker2_validate;miRNATAP -0.332765109923847 1.85007209127599e-06 26758252 Onco miR 24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer; In the present study miR-24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of GC; Studies from both in vitro and in vivo shown that miR-24 regulates BCL2L11 expression by directly binding with 3'UTR of mRNA thus promoting cell growth migration while inhibiting cell apoptosis gastric cancer hsa-miR-32-5p BCL2L11 0.407826130035097 7.26884631998646e-06 -0.280076657339514 0.000362193641126999 miRNAWalker2_validate;miRTarBase;miRNATAP -0.150997188778666 0.00150057444660945 NA NA NA hsa-miR-182-5p BDNF -0.608710746044567 0.0025264935278104 1.32053589639348 4.6461489093674e-09 MirTarget;miRNATAP -0.320911985212199 2.19358929074297e-07 NA NA NA hsa-miR-22-3p BDNF 0.198460552200729 0.00761005672059428 1.32053589639348 4.6461489093674e-09 miRNAWalker2_validate;miRTarBase -0.934418001650865 4.10404904290013e-08 NA NA NA hsa-miR-3065-3p BDNF -1.64500070417457 9.57561660036697e-16 1.32053589639348 4.6461489093674e-09 MirTarget;miRNATAP -0.173566329974244 0.00341422805602149 NA NA NA hsa-miR-30b-5p BDNF -1.18330589477119 6.8341618466966e-27 1.32053589639348 4.6461489093674e-09 miRNATAP -0.418679389730946 7.95864809848167e-05 NA NA NA hsa-miR-361-5p BDNF 0.0514169367202078 0.382929376393199 1.32053589639348 4.6461489093674e-09 PITA;miRanda;miRNATAP -0.579854997171823 0.00910447765702249 NA NA NA hsa-miR-3913-5p BDNF 0.136365354811444 0.24239516424369 1.32053589639348 4.6461489093674e-09 mirMAP -0.437476166734317 0.000137119405950826 NA NA NA hsa-miR-508-3p BDNF -3.41433288024917 3.47699261121175e-37 1.32053589639348 4.6461489093674e-09 PITA;miRNATAP -0.227379255506386 4.7723104940365e-08 NA NA NA hsa-miR-429 BRCA1 -2.16569233119434 2.66862243626443e-37 0.791236489117888 1.47641479177548e-17 miRanda;miRNATAP -0.205317778684137 4.26584160245299e-14 NA NA NA hsa-miR-126-5p CASP9 0.785607261431085 5.77058629454465e-13 -0.640493643795454 4.84619402433504e-23 MirTarget -0.209827969339424 2.33512843630455e-10 NA NA NA hsa-miR-130b-5p CASP9 0.92990617673277 3.75880436852717e-12 -0.640493643795454 4.84619402433504e-23 mirMAP -0.133542104018384 1.00105836546299e-06 NA NA NA hsa-miR-140-5p CASP9 0.504309496243674 3.09884038729031e-11 -0.640493643795454 4.84619402433504e-23 miRanda -0.223105511125259 5.15163770332575e-06 NA NA NA hsa-miR-15a-5p CASP9 1.42663930007845 1.36006952074963e-57 -0.640493643795454 4.84619402433504e-23 mirMAP -0.233625908587689 2.44769264872863e-11 NA NA NA hsa-miR-15b-5p CASP9 0.773001494057531 1.71784656078957e-16 -0.640493643795454 4.84619402433504e-23 mirMAP -0.134379770025843 0.00056125692133512 NA NA NA hsa-miR-16-5p CASP9 0.934012514027655 4.85417898318515e-24 -0.640493643795454 4.84619402433504e-23 mirMAP -0.248606565461915 4.07153687129857e-11 NA NA NA hsa-miR-17-5p CASP9 0.494260110870015 3.8348005261e-09 -0.640493643795454 4.84619402433504e-23 TargetScan -0.125797566438446 0.00510774359125448 NA NA NA hsa-miR-186-5p CASP9 0.507217561043443 9.04455748270995e-10 -0.640493643795454 4.84619402433504e-23 mirMAP -0.146721856991177 0.00121342804051267 NA NA NA hsa-miR-342-5p CASP9 1.37011183051517 4.99462376051624e-28 -0.640493643795454 4.84619402433504e-23 MirTarget -0.152515106474698 3.45836685797776e-08 NA NA NA hsa-miR-590-3p CASP9 1.13702599385212 3.53435739887793e-22 -0.640493643795454 4.84619402433504e-23 miRanda -0.159671085910094 1.12473604347217e-07 NA NA NA hsa-let-7e-5p CCND1 -0.727009689927955 1.30690859412163e-11 2.13480598480786 2.71111034411853e-47 miRTarBase;miRNATAP -0.309874613270473 0.000283950841354646 NA NA NA hsa-let-7g-5p CCND1 -0.739744008507763 1.07979566264383e-14 2.13480598480786 2.71111034411853e-47 miRNATAP -0.622969784922631 1.85126618527679e-11 NA NA NA hsa-miR-106a-5p CCND1 -0.830908656792615 2.67547872901508e-10 2.13480598480786 2.71111034411853e-47 MirTarget;miRNATAP -0.425464553504269 5.26102842088565e-10 NA NA NA hsa-miR-135a-5p CCND1 -2.13422485001223 6.29449029671498e-14 2.13480598480786 2.71111034411853e-47 mirMAP -0.135832732621826 2.9303290026017e-05 NA NA NA hsa-miR-183-5p CCND1 -1.21596931064487 1.31473205758898e-08 2.13480598480786 2.71111034411853e-47 miRNAWalker2_validate -0.374903452579708 3.93459169450664e-20 NA NA NA hsa-miR-193b-3p CCND1 -0.273325765316079 0.104328826585392 2.13480598480786 2.71111034411853e-47 miRNAWalker2_validate;miRTarBase;MirTarget -0.242980057535361 1.3298535415108e-05 27071318;20655737;20304954;21893020;26129688 MicroRNA 193b inhibits the proliferation migration and invasion of gastric cancer cells via targeting cyclin D1; Further mechanism study indicated that CCND1 was a direct target of miR-193b in GC;CCND1 and ETS1 were revealed to be regulated by miR-193b directly;MicroRNA 193b represses cell proliferation and regulates cyclin D1 in melanoma; Overexpression of miR-193b in Malme-3M cells down-regulated CCND1 mRNA and protein by > or = 50%; A luciferase reporter assay confirmed that miR-193b directly regulates CCND1 by binding to the 3'untranslated region of CCND1 mRNA; These studies indicate that miR-193b represses cell proliferation and regulates CCND1 expression and suggest that dysregulation of miR-193b may play an important role in melanoma development;In a previous study we reported that miR-193b represses cell proliferation and regulates cyclin D1 in melanoma cells suggesting that miR-193b could act as a tumor suppressor;Epigenetically altered miR 193b targets cyclin D1 in prostate cancer; It has been suggested that miR-193b targets cyclin D1 in several malignancies; Here our aim was to determine if miR-193b targets cyclin D1 in prostate cancer; Furthermore the PC cell lines 22Rv1 and VCaP which express low levels of miR-193b and high levels of CCND1 showed significant growth retardation when treated with a CDK4/6 inhibitor; In contrast the inhibitor had no effect on the growth of PC-3 and DU145 cells with high miR-193b and low CCND1 expression; Taken together our data demonstrate that miR-193b targets cyclin D1 in prostate cancer ;;;; gastric cancer;liver cancer;melanoma;melanoma;prostate cancer hsa-miR-20b-5p CCND1 -1.30218163823367 6.87172815978149e-17 2.13480598480786 2.71111034411853e-47 MirTarget;miRNATAP -0.398854407061578 1.06454795591623e-12 NA NA NA hsa-miR-214-5p CCND1 -1.44418790803397 1.50873538772684e-16 2.13480598480786 2.71111034411853e-47 MirTarget -0.347168835410485 4.02103564566879e-12 NA NA NA hsa-miR-29a-3p CCND1 -0.431613225927952 4.10166815070288e-08 2.13480598480786 2.71111034411853e-47 mirMAP -0.939711765610188 1.68520368520268e-16 NA NA NA hsa-miR-29b-3p CCND1 -0.228125979913806 0.0271621721891603 2.13480598480786 2.71111034411853e-47 mirMAP -0.387608162335363 2.20893060555751e-05 NA NA NA hsa-miR-495-3p CCND1 -0.742293735164333 7.11373308013543e-05 2.13480598480786 2.71111034411853e-47 MirTarget -0.181526805649212 0.000432098784713278 NA NA NA hsa-miR-9-5p CCND1 -2.23538606210968 1.28143998950751e-12 2.13480598480786 2.71111034411853e-47 miRNAWalker2_validate -0.163701601563252 7.92305196930194e-09 NA NA NA hsa-let-7e-5p CCND2 -0.727009689927955 1.30690859412163e-11 1.12254248674744 2.60370825886318e-19 miRNATAP -0.233612834039481 0.000392482925172286 NA NA NA hsa-let-7g-5p CCND2 -0.739744008507763 1.07979566264383e-14 1.12254248674744 2.60370825886318e-19 miRNATAP -0.192686043584521 0.0089075831083671 NA NA NA hsa-miR-106a-5p CCND2 -0.830908656792615 2.67547872901508e-10 1.12254248674744 2.60370825886318e-19 miRNATAP -0.225423059951479 2.69299129795332e-05 NA NA NA hsa-miR-10a-3p CCND2 -1.40380922426511 3.42207767326254e-23 1.12254248674744 2.60370825886318e-19 mirMAP -0.262198638789585 6.25176630952157e-08 NA NA NA hsa-miR-10b-3p CCND2 -0.8205021989966 7.84331443044781e-21 1.12254248674744 2.60370825886318e-19 mirMAP -0.448238682535571 6.77944940531982e-09 NA NA NA hsa-miR-135a-5p CCND2 -2.13422485001223 6.29449029671498e-14 1.12254248674744 2.60370825886318e-19 miRNATAP -0.131225655723756 1.33192381495194e-07 NA NA NA hsa-miR-141-3p CCND2 -5.87110686537457 1.20877726722907e-85 1.12254248674744 2.60370825886318e-19 MirTarget;TargetScan -0.139228651988037 1.29114997683213e-14 NA NA NA hsa-miR-188-5p CCND2 -1.74586655806628 1.50431624674552e-28 1.12254248674744 2.60370825886318e-19 PITA;mirMAP -0.254549789518694 2.9475657150123e-09 NA NA NA hsa-miR-200a-3p CCND2 -1.43409013664263 2.00188483717828e-20 1.12254248674744 2.60370825886318e-19 MirTarget -0.212833658265287 1.19682362163716e-06 NA NA NA hsa-miR-20b-5p CCND2 -1.30218163823367 6.87172815978149e-17 1.12254248674744 2.60370825886318e-19 miRNATAP -0.259528470369076 2.90568654364943e-09 NA NA NA hsa-miR-26a-1-3p CCND2 -1.56107117111696 6.75439319582901e-15 1.12254248674744 2.60370825886318e-19 mirMAP -0.123054440828334 0.000561186412955267 NA NA NA hsa-miR-29a-3p CCND2 -0.431613225927952 4.10166815070288e-08 1.12254248674744 2.60370825886318e-19 MirTarget;miRNATAP -0.257180845680541 0.00521051024582081 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-29a-5p CCND2 -0.519003718107105 1.03351148282116e-06 1.12254248674744 2.60370825886318e-19 mirMAP -0.175805947483669 0.00980240816278221 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-29c-3p CCND2 -0.238671318446745 0.0141475322347596 1.12254248674744 2.60370825886318e-19 MirTarget;miRNATAP -0.244609702834514 0.0011551466386057 NA NA NA hsa-miR-3065-3p CCND2 -1.64500070417457 9.57561660036697e-16 1.12254248674744 2.60370825886318e-19 MirTarget;miRNATAP -0.15735746874687 2.91648572740269e-06 NA NA NA hsa-miR-30a-3p CCND2 -0.955360819934585 1.97009535429185e-20 1.12254248674744 2.60370825886318e-19 mirMAP -0.322061265215125 1.10079970812633e-06 NA NA NA hsa-miR-30d-3p CCND2 -0.249777194282131 0.00235356711813496 1.12254248674744 2.60370825886318e-19 mirMAP -0.528583706650002 1.57965043070812e-09 NA NA NA hsa-miR-335-5p CCND2 -2.09515619961552 1.03765771499548e-25 1.12254248674744 2.60370825886318e-19 miRNAWalker2_validate -0.125391196936535 0.000218373131234068 NA NA NA hsa-miR-378a-3p CCND2 0.287244802401236 0.0501155019984562 1.12254248674744 2.60370825886318e-19 miRNAWalker2_validate -0.155216456838451 0.00181246322617494 NA NA NA hsa-miR-429 CCND2 -2.16569233119434 2.66862243626443e-37 1.12254248674744 2.60370825886318e-19 miRNATAP -0.226547302813025 1.44251591184469e-09 NA NA NA hsa-miR-500a-5p CCND2 -1.28374735824553 1.95870374809798e-20 1.12254248674744 2.60370825886318e-19 mirMAP -0.227276642384328 3.82424468920894e-06 NA NA NA hsa-miR-501-5p CCND2 -1.1103073934745 1.81589804886553e-16 1.12254248674744 2.60370825886318e-19 PITA;mirMAP;miRNATAP -0.210338351972789 4.15719063926169e-05 NA NA NA hsa-miR-577 CCND2 -1.48881999472397 7.03080165111147e-10 1.12254248674744 2.60370825886318e-19 PITA;mirMAP -0.106625188470732 0.000293795265070961 NA NA NA hsa-miR-660-5p CCND2 -1.20833564582661 8.48975910642834e-23 1.12254248674744 2.60370825886318e-19 mirMAP -0.376740011929223 2.58290869632093e-12 NA NA NA hsa-miR-362-3p CCND3 -0.753214251798232 3.0025661608035e-07 0.51821271483815 4.41964906922001e-09 miRanda -0.139754455099983 4.25864164139051e-05 NA NA NA hsa-miR-501-5p CCND3 -1.1103073934745 1.81589804886553e-16 0.51821271483815 4.41964906922001e-09 PITA -0.131433527243481 0.000178229069185252 NA NA NA hsa-miR-26a-5p CCNE1 -0.202091714279613 0.00166918288801054 0.816753258090501 1.03152776155512e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.415437722985115 0.000232432307489198 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-26b-5p CCNE1 -0.251437253429904 0.00270935785098697 0.816753258090501 1.03152776155512e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.23088787472047 0.00736354340634514 NA NA NA hsa-miR-141-3p CCNE2 -5.87110686537457 1.20877726722907e-85 2.0856989067869 1.01741376720221e-50 TargetScan;miRNATAP -0.270473765628803 1.14631686095266e-39 NA NA NA hsa-miR-200a-3p CCNE2 -1.43409013664263 2.00188483717828e-20 2.0856989067869 1.01741376720221e-50 miRNAWalker2_validate;miRTarBase;miRNATAP -0.393696406224143 8.91288390936764e-14 22183793 Targetscan analysis suggested cyclin E2 as potential target of miR-200a b c; Luciferase reporter assay using vectors containing the 3'UTR of cyclin E2 showed that miR-200a b c could suppress luciferase activities; RT-PCR and immunoblotting studies revealed that overexpression of miR-200a b c reduced the mRNA and protein levels of cyclin E2 respectively lymphoma hsa-miR-200b-3p CCNE2 -1.70383252137161 2.38979336321755e-30 2.0856989067869 1.01741376720221e-50 miRNAWalker2_validate;miRTarBase -0.486981417898501 6.49815012075116e-21 NA NA NA hsa-miR-200c-3p CCNE2 -5.40303134829523 2.74173143360645e-94 2.0856989067869 1.01741376720221e-50 miRNAWalker2_validate;miRTarBase -0.294010001889963 1.26125378006145e-37 NA NA NA hsa-miR-26a-5p CCNE2 -0.202091714279613 0.00166918288801054 2.0856989067869 1.01741376720221e-50 miRNAWalker2_validate;miRTarBase;miRNATAP -0.532059064032621 0.000173741814281565 24116110;21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression poor survival;progression pancreatic cancer;acute myeloid leukemia hsa-miR-30a-5p CCNE2 -0.778411951775343 2.73322451127932e-16 2.0856989067869 1.01741376720221e-50 miRNATAP -0.723899209778526 7.38760000789901e-17 NA NA NA hsa-miR-30b-5p CCNE2 -1.18330589477119 6.8341618466966e-27 2.0856989067869 1.01741376720221e-50 miRNAWalker2_validate;miRTarBase -0.631291526113636 1.2680612848159e-18 22384020 A luciferase-based reporter assay demonstrated that miR-30b post-transcriptionally reduced 27% p = 0.005 of the gene expression by interacting with two binding sites in the 3'-UTR of CCNE2; The upregulation of miR-30b by trastuzumab may play a biological role in trastuzumab-induced cell growth inhibition by targeting CCNE2 breast cancer hsa-miR-30c-5p CCNE2 -1.08783070774238 2.02505402525786e-24 2.0856989067869 1.01741376720221e-50 miRNATAP -0.575864780888779 3.04753489838907e-14 NA NA NA hsa-miR-335-3p CCNE2 -1.36498175550207 6.84287752180534e-13 2.0856989067869 1.01741376720221e-50 mirMAP -0.152792321205036 0.00081907200415046 NA NA NA hsa-miR-429 CCNE2 -2.16569233119434 2.66862243626443e-37 2.0856989067869 1.01741376720221e-50 PITA;miRanda;miRNATAP -0.459044601341311 9.56581900492176e-26 NA NA NA hsa-miR-514a-3p CCNE2 -3.60916038800272 7.44698991540685e-35 2.0856989067869 1.01741376720221e-50 miRNATAP -0.19830492963348 9.59557758012475e-14 NA NA NA hsa-miR-532-3p CCNE2 -1.759223962964 7.9077916669414e-40 2.0856989067869 1.01741376720221e-50 PITA -0.590255637068497 1.15370880093858e-26 NA NA NA hsa-miR-577 CCNE2 -1.48881999472397 7.03080165111147e-10 2.0856989067869 1.01741376720221e-50 PITA;miRNATAP -0.177978903599561 7.85966733789834e-07 NA NA NA hsa-miR-10b-3p CDK2 -0.8205021989966 7.84331443044781e-21 0.371509137108531 5.99773845629112e-11 mirMAP -0.170932324193587 5.80500988570859e-07 NA NA NA hsa-miR-10b-5p CDK2 -0.89971464210447 1.18190532299934e-20 0.371509137108531 5.99773845629112e-11 miRNAWalker2_validate -0.118692565754821 0.000146070422960447 NA NA NA hsa-miR-200b-3p CDK2 -1.70383252137161 2.38979336321755e-30 0.371509137108531 5.99773845629112e-11 TargetScan -0.12970122404519 1.01762720330858e-11 27496804 Correlating with the frequent loss of miR-200b in ESCC both CDK2 and PAF levels are significantly increased in ESCC tumors compared to case-matched normal tissues n = 119 both P < 0.0001 and correlate with markedly reduced survival P = 0.007 and P = 0.041 respectively poor survival esophageal cancer hsa-miR-23b-3p CDK2 -0.533749586990474 2.46924776953771e-10 0.371509137108531 5.99773845629112e-11 miRNAWalker2_validate -0.219368132932182 1.99509995795993e-09 NA NA NA hsa-miR-361-5p CDK2 0.0514169367202078 0.382929376393199 0.371509137108531 5.99773845629112e-11 miRNAWalker2_validate -0.193286996057625 0.000531264325186741 NA NA NA hsa-miR-429 CDK2 -2.16569233119434 2.66862243626443e-37 0.371509137108531 5.99773845629112e-11 miRanda;miRNATAP -0.129348459383424 9.83216432751438e-16 NA NA NA hsa-let-7a-3p CDK6 0.0677487960013088 0.460458477653989 -0.337517762588933 0.000683930986632226 miRNATAP -0.191952475229568 0.00152326159633293 NA NA NA hsa-miR-101-3p CDK6 0.683973909682285 2.88573524246948e-15 -0.337517762588933 0.000683930986632226 mirMAP -0.230464143338434 0.000161085212410487 NA NA NA hsa-miR-106b-5p CDK6 1.07509411417907 2.11739194181878e-36 -0.337517762588933 0.000683930986632226 mirMAP -0.160408664539701 0.00574724787212677 NA NA NA hsa-miR-107 CDK6 0.140046250553248 0.0943611632552367 -0.337517762588933 0.000683930986632226 miRNAWalker2_validate;miRTarBase;PITA;miRNATAP -0.199675588030875 0.00266957921136072 19407485;22491216;21264532;19688090 Enforced expression of miR-107 in MiaPACA-2 and PANC-1 cells downregulated in vitro growth and this was associated with repression of the putative miR-107 target cyclin-dependent kinase 6 thereby providing a functional basis for the epigenetic inactivation of this miRNA in pancreatic cancer;Levels of known miR-107 targets protein kinase Cε PKCε cyclin-dependent kinase 6 CDK6 and hypoxia-inducible factor 1-β HIF1-β decreased following NP/pre-miR-107 treatment;We have identified miR-107 as a potential regulator of CDK6 expression; A bioinformatics search revealed a putative target site for miR-107 within the CDK6 3' untranslated region; Expression of miR-107 in gastric cancer cell lines was found inversely correlated with CDK6 expression; miR-107 could significantly suppress CDK6 3' UTR luciferase reporter activity and this effect was not detectable when the putative 3' UTR target site was mutated; Consistent with the results of the reporter assay ectopic expression of miR-107 reduced both mRNA and protein expression levels of CDK6 inhibited proliferation induced G1 cell cycle arrest and blocked invasion of the gastric cancer cells; Our results suggest that miR-107 may have a tumor suppressor function by directly targeting CDK6 to inhibit the proliferation and invasion activities of gastric cancer cells;Using miRNA-target prediction analyses and the array data we listed up a set of likely targets of miR-107 and miR-185 for G1 cell cycle arrest and validate a subset of them using real-time RT-PCR and immunoblotting for CDK6 ;;; pancreatic cancer;head and neck cancer;gastric cancer;lung squamous cell cancer hsa-miR-148a-5p CDK6 0.415500302855613 0.000691460831436767 -0.337517762588933 0.000683930986632226 mirMAP -0.159259648718724 0.000364313889365372 NA NA NA hsa-miR-15a-5p CDK6 1.42663930007845 1.36006952074963e-57 -0.337517762588933 0.000683930986632226 miRNATAP -0.203915063579853 7.69806540214174e-05 NA NA NA hsa-miR-16-1-3p CDK6 1.51429140700091 3.17219833254498e-37 -0.337517762588933 0.000683930986632226 mirMAP -0.136395924905055 0.00114400622656354 NA NA NA hsa-miR-195-5p CDK6 0.346502644882604 0.0092562828415903 -0.337517762588933 0.000683930986632226 miRNAWalker2_validate;miRTarBase -0.186888455162125 5.00682650566728e-06 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-29c-3p CDK6 -0.238671318446745 0.0141475322347596 -0.337517762588933 0.000683930986632226 miRNAWalker2_validate;miRTarBase;miRNATAP -0.205490672146365 0.000288499978675504 26396669 Furthermore through qPCR and Western blot assays confirmed that overexpression of miR-29c reduced CDK6 mRNA and protein levels; miR-29c could inhibit the proliferation migration and invasion of bladder cancer cells via regulating CDK6 bladder cancer hsa-miR-3613-5p CDK6 1.6648190889407 3.78720979041391e-41 -0.337517762588933 0.000683930986632226 miRNATAP -0.143151845849858 0.000265548659050746 NA NA NA hsa-miR-374a-3p CDK6 1.13863935833993 2.79089304015401e-44 -0.337517762588933 0.000683930986632226 mirMAP -0.215475812324155 0.000261280963064821 NA NA NA hsa-miR-374b-5p CDK6 0.0804104684417872 0.365593963035077 -0.337517762588933 0.000683930986632226 mirMAP -0.255765470017787 3.9713823905864e-05 NA NA NA hsa-miR-378a-3p CDK6 0.287244802401236 0.0501155019984562 -0.337517762588933 0.000683930986632226 mirMAP -0.101261595573785 0.00710290616527283 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-497-5p CDK6 0.227757383708836 0.0600073987853074 -0.337517762588933 0.000683930986632226 miRNATAP -0.146760711868953 0.00127145490092567 NA NA NA hsa-miR-106a-5p CDKN1A -0.830908656792615 2.67547872901508e-10 0.933852663827849 4.55444675105513e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.218600628700736 2.88939391057469e-05 25510666 After prediction with online software we further used dual-luciferase reporter gene assay to ensure that TP53INP1 and CDKN1A might be the direct targets of miR-106a liver cancer hsa-miR-10b-5p CDKN1A -0.89971464210447 1.18190532299934e-20 0.933852663827849 4.55444675105513e-14 miRNAWalker2_validate;miRTarBase -0.297067989678752 1.67500183935337e-05 NA NA NA hsa-miR-125a-5p CDKN1A -0.561874059994802 7.3931856356891e-13 0.933852663827849 4.55444675105513e-14 miRNAWalker2_validate;miRTarBase -0.32978155373342 0.000181727625486425 NA NA NA hsa-miR-20b-5p CDKN1A -1.30218163823367 6.87172815978149e-17 0.933852663827849 4.55444675105513e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.137763480888379 0.00149273487605735 NA NA NA hsa-miR-30b-3p CDKN1A -1.64703050862226 1.89878531036464e-31 0.933852663827849 4.55444675105513e-14 MirTarget -0.262528533661573 5.81397764129021e-09 NA NA NA hsa-miR-335-5p CDKN1A -2.09515619961552 1.03765771499548e-25 0.933852663827849 4.55444675105513e-14 miRNAWalker2_validate -0.129015957169685 9.12565108889168e-05 NA NA NA hsa-miR-345-5p CDKN1A -0.953479075875024 8.95459389953487e-14 0.933852663827849 4.55444675105513e-14 miRNAWalker2_validate;miRTarBase;MirTarget -0.197411366375212 0.000212824701961514 NA NA NA hsa-miR-363-3p CDKN1A -1.93551166555337 4.45368477487614e-32 0.933852663827849 4.55444675105513e-14 miRNAWalker2_validate;miRTarBase -0.206355244698441 9.10387020600093e-08 NA NA NA hsa-miR-429 CDKN1A -2.16569233119434 2.66862243626443e-37 0.933852663827849 4.55444675105513e-14 miRNATAP -0.148103052504028 6.31944175096861e-05 NA NA NA hsa-miR-221-3p CDKN1B 0.337895669520713 0.0136448974691037 0.239879984710899 0.000337937760572074 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.169197893944767 1.33586254266414e-10 23637992;19953484;23939688;19126397;20146005;23967190;17569667;22992757;17721077;20461750 miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression progression;;;;staging;tumorigenesis;;;;;poor survival breast cancer;glioblastoma;breast cancer;melanoma;liver cancer;pancreatic cancer;prostate cancer;breast cancer;glioblastoma;ovarian cancer hsa-miR-222-3p CDKN1B 0.214811008033524 0.0965295551752457 0.239879984710899 0.000337937760572074 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.162802081961889 7.56681536640924e-09 19953484;26912358;24895988;24137356;17569667;27282281;20461750 Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;Besides microvesicle marker characterization we evidenced that miR-222 exosomal expression mostly reflected its abundance in the cells of origin correctly paralleled by repression of its target genes such as p27Kip1 and induction of the PI3K/AKT pathway thus confirming its functional implication in cancer;MiR-222 plays an important role in the tumorigenesis of CC possibly by specifically down-regulating p27Kip1 and PTEN;miR 222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1; miR-222 upregulation induced an enhancement of ovarian cancer cell proliferation potential possibly by downregulating its target P27Kip1; A bioinformatic analysis showed that the 3'-UTR of the P27Kip1 mRNA contained a highly-conserved putative miR-222 binding site; Luciferase reporter assays demonstrated that P27Kip1 was a direct target of miR-222; Consistently there was an inverse correlation between the P27Kip1 and miR-222 expression levels in the ovarian cancer cell lines and tissues;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;miR 222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27kip1 expression; Immunofluorescence showed that miR-222 altered the subcellular location of p27kip1 in nucleus; The results showed that downregulation of miR-222 in MCF-7/Adr increased sensitivity to Adr and Adr-induced apoptosis and arrested the cells in G1 phase accompanied by more expressions of p27kip1 especially in nucleus; Taken together the results found that miR-222 induced Adr-resistance at least in part via suppressing p27kip1 expression and altering its subcellular localization and miR-222 inhibitors could reverse Adr-resistance of breast cancer cells;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression ;;tumorigenesis;;;drug resistance;poor survival glioblastoma;melanoma;cervical and endocervical cancer;ovarian cancer;prostate cancer;breast cancer;ovarian cancer hsa-miR-30e-3p CDKN1B -0.205602546270795 0.00132666419729688 0.239879984710899 0.000337937760572074 MirTarget -0.176307424226376 0.00265440694535281 NA NA NA hsa-miR-199a-3p CHAD -1.61607426368083 1.97964980193147e-26 -0.230613652892076 0.348509254654582 MirTarget;miRNATAP -0.264068986727698 0.00129848615505299 NA NA NA hsa-miR-199b-3p CHAD -1.61804389801139 1.97668652730486e-26 -0.230613652892076 0.348509254654582 MirTarget -0.263487006654067 0.00131320370658832 NA NA NA hsa-miR-222-5p CHAD 0.345754786636279 0.0500394455965523 -0.230613652892076 0.348509254654582 MirTarget -0.286580194607173 0.000237473728251074 NA NA NA hsa-miR-126-5p CHUK 0.785607261431085 5.77058629454465e-13 -0.85746072421144 8.10744991906236e-38 MirTarget;mirMAP;miRNATAP -0.141478846302423 0.000105653732136013 NA NA NA hsa-miR-15a-5p CHUK 1.42663930007845 1.36006952074963e-57 -0.85746072421144 8.10744991906236e-38 miRNAWalker2_validate;miRTarBase;MirTarget -0.318418636879753 7.69752994687939e-18 NA NA NA hsa-miR-15b-5p CHUK 0.773001494057531 1.71784656078957e-16 -0.85746072421144 8.10744991906236e-38 MirTarget -0.225889800417735 5.44303807977529e-08 NA NA NA hsa-miR-16-5p CHUK 0.934012514027655 4.85417898318515e-24 -0.85746072421144 8.10744991906236e-38 miRNAWalker2_validate;miRTarBase;MirTarget -0.228889855351981 2.57589362388376e-08 NA NA NA hsa-miR-195-5p CHUK 0.346502644882604 0.0092562828415903 -0.85746072421144 8.10744991906236e-38 miRNAWalker2_validate;MirTarget -0.157478463247597 2.5847715765755e-07 NA NA NA hsa-miR-223-3p CHUK 1.23291409735619 1.07767240442694e-17 -0.85746072421144 8.10744991906236e-38 miRNAWalker2_validate;miRTarBase -0.158778742351017 2.71041182397134e-09 NA NA NA hsa-miR-23a-3p CHUK 0.761438723382355 4.09310879199257e-27 -0.85746072421144 8.10744991906236e-38 MirTarget -0.426829131699392 2.80265744990605e-16 NA NA NA hsa-miR-342-3p CHUK 1.4124432570595 1.07208971556131e-28 -0.85746072421144 8.10744991906236e-38 miRanda -0.194422482412743 1.9269792265026e-11 NA NA NA hsa-miR-497-5p CHUK 0.227757383708836 0.0600073987853074 -0.85746072421144 8.10744991906236e-38 MirTarget -0.149867793994567 9.91621768564792e-06 NA NA NA hsa-miR-590-3p CHUK 1.13702599385212 3.53435739887793e-22 -0.85746072421144 8.10744991906236e-38 miRanda;mirMAP -0.204551923277616 2.23702640558868e-10 NA NA NA hsa-miR-590-5p CHUK 0.709763558412506 1.11883921359361e-11 -0.85746072421144 8.10744991906236e-38 miRanda -0.177887016696357 2.94637831990317e-06 NA NA NA hsa-let-7e-5p COL1A1 -0.727009689927955 1.30690859412163e-11 2.51766806092129 1.02912948146724e-23 miRNATAP -0.53535989142091 6.47275213324096e-05 NA NA NA hsa-let-7g-5p COL1A1 -0.739744008507763 1.07979566264383e-14 2.51766806092129 1.02912948146724e-23 miRNATAP -0.642234744411444 1.59926896633574e-05 NA NA NA hsa-miR-106a-5p COL1A1 -0.830908656792615 2.67547872901508e-10 2.51766806092129 1.02912948146724e-23 mirMAP -0.32756432227868 0.0029615476614717 NA NA NA hsa-miR-20b-5p COL1A1 -1.30218163823367 6.87172815978149e-17 2.51766806092129 1.02912948146724e-23 mirMAP -0.486396274967718 5.53040127711441e-08 NA NA NA hsa-miR-29c-3p COL1A1 -0.238671318446745 0.0141475322347596 2.51766806092129 1.02912948146724e-23 miRNAWalker2_validate;miRTarBase;miRNATAP -0.738288595178453 1.18033711323556e-06 NA NA NA hsa-miR-30a-3p COL1A1 -0.955360819934585 1.97009535429185e-20 2.51766806092129 1.02912948146724e-23 mirMAP -1.44063702622346 3.79732507754676e-31 NA NA NA hsa-miR-30b-3p COL1A1 -1.64703050862226 1.89878531036464e-31 2.51766806092129 1.02912948146724e-23 miRNATAP -0.790083787800381 6.551105530343e-18 NA NA NA hsa-miR-30d-3p COL1A1 -0.249777194282131 0.00235356711813496 2.51766806092129 1.02912948146724e-23 mirMAP -1.09866037015696 7.26440447084517e-10 NA NA NA hsa-miR-30e-3p COL1A1 -0.205602546270795 0.00132666419729688 2.51766806092129 1.02912948146724e-23 mirMAP -1.58167089874789 4.96187492537979e-12 NA NA NA hsa-miR-532-3p COL1A1 -1.759223962964 7.9077916669414e-40 2.51766806092129 1.02912948146724e-23 PITA;miRNATAP -0.947046892181277 5.49121285938181e-25 NA NA NA hsa-miR-577 COL1A1 -1.48881999472397 7.03080165111147e-10 2.51766806092129 1.02912948146724e-23 MirTarget;PITA;miRNATAP -0.400640006383739 7.58867069768276e-12 NA NA NA hsa-let-7g-5p COL1A2 -0.739744008507763 1.07979566264383e-14 1.44422646571225 4.13059504084961e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.36703668279415 0.000890423021559005 NA NA NA hsa-miR-125a-5p COL1A2 -0.561874059994802 7.3931856356891e-13 1.44422646571225 4.13059504084961e-14 miRanda -0.381709309749795 0.00526772589851098 NA NA NA hsa-miR-29c-3p COL1A2 -0.238671318446745 0.0141475322347596 1.44422646571225 4.13059504084961e-14 miRNAWalker2_validate;miRTarBase;miRNATAP -0.589864349491137 1.2961351972275e-07 NA NA NA hsa-miR-30a-3p COL1A2 -0.955360819934585 1.97009535429185e-20 1.44422646571225 4.13059504084961e-14 MirTarget -0.986599645035033 2.9088696279621e-26 NA NA NA hsa-miR-30d-3p COL1A2 -0.249777194282131 0.00235356711813496 1.44422646571225 4.13059504084961e-14 MirTarget -0.843349197467083 1.30918007076291e-10 NA NA NA hsa-miR-30e-3p COL1A2 -0.205602546270795 0.00132666419729688 1.44422646571225 4.13059504084961e-14 MirTarget -1.09284815967613 1.20848944930221e-10 NA NA NA hsa-miR-363-3p COL1A2 -1.93551166555337 4.45368477487614e-32 1.44422646571225 4.13059504084961e-14 MirTarget -0.266081744954766 9.49238769907248e-06 NA NA NA hsa-miR-500a-5p COL1A2 -1.28374735824553 1.95870374809798e-20 1.44422646571225 4.13059504084961e-14 miRNATAP -0.521895584422556 5.17038442715073e-13 NA NA NA hsa-let-7g-5p COL4A1 -0.739744008507763 1.07979566264383e-14 1.94183996411033 2.41643075670989e-41 miRNATAP -0.4636926813178 2.60842499328651e-07 NA NA NA hsa-miR-125a-5p COL4A1 -0.561874059994802 7.3931856356891e-13 1.94183996411033 2.41643075670989e-41 miRNAWalker2_validate;miRanda -0.309627336969526 0.00608677526515925 NA NA NA hsa-miR-193b-3p COL4A1 -0.273325765316079 0.104328826585392 1.94183996411033 2.41643075670989e-41 miRNAWalker2_validate -0.162154654064249 0.00258542407763727 NA NA NA hsa-miR-29a-3p COL4A1 -0.431613225927952 4.10166815070288e-08 1.94183996411033 2.41643075670989e-41 miRNAWalker2_validate;miRTarBase;miRNATAP -0.714590899084669 1.38694561418969e-10 NA NA NA hsa-miR-29b-3p COL4A1 -0.228125979913806 0.0271621721891603 1.94183996411033 2.41643075670989e-41 miRNAWalker2_validate;miRTarBase;miRNATAP -0.466990420904892 7.25931186395536e-08 NA NA NA hsa-miR-29c-3p COL4A1 -0.238671318446745 0.0141475322347596 1.94183996411033 2.41643075670989e-41 miRNAWalker2_validate;miRTarBase;miRNATAP -0.477745072574213 2.22805368463949e-07 NA NA NA hsa-miR-362-3p COL4A1 -0.753214251798232 3.0025661608035e-07 1.94183996411033 2.41643075670989e-41 miRanda -0.410332593708248 1.47656230956698e-11 NA NA NA hsa-miR-429 COL4A1 -2.16569233119434 2.66862243626443e-37 1.94183996411033 2.41643075670989e-41 miRanda;miRNATAP -0.472001078335547 4.38287232821249e-27 NA NA NA hsa-miR-99a-5p COL4A1 -0.609395142445514 1.66643233447031e-07 1.94183996411033 2.41643075670989e-41 miRNAWalker2_validate -0.316765997519408 3.16106692571417e-05 NA NA NA hsa-let-7g-5p COL4A2 -0.739744008507763 1.07979566264383e-14 1.57393045236065 5.49853780312115e-35 miRNATAP -0.420904326300412 6.44055693457281e-08 NA NA NA hsa-miR-10a-5p COL4A2 -1.17164272592931 4.86621098042279e-24 1.57393045236065 5.49853780312115e-35 miRNAWalker2_validate -0.400725593079404 7.2445275580152e-11 NA NA NA hsa-miR-29a-3p COL4A2 -0.431613225927952 4.10166815070288e-08 1.57393045236065 5.49853780312115e-35 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.521798741269153 8.45354922139295e-08 NA NA NA hsa-miR-29b-3p COL4A2 -0.228125979913806 0.0271621721891603 1.57393045236065 5.49853780312115e-35 miRTarBase;MirTarget;miRNATAP -0.38356161191029 3.53590299862073e-07 NA NA NA hsa-miR-29c-3p COL4A2 -0.238671318446745 0.0141475322347596 1.57393045236065 5.49853780312115e-35 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.355587770579371 9.66726137131373e-06 NA NA NA hsa-miR-30c-2-3p COL4A2 -1.28402709024345 6.77577627955178e-25 1.57393045236065 5.49853780312115e-35 MirTarget -0.443927201799034 2.55003587016513e-15 NA NA NA hsa-miR-9-5p COL4A2 -2.23538606210968 1.28143998950751e-12 1.57393045236065 5.49853780312115e-35 MirTarget;miRNATAP -0.100803286678184 2.29866127265654e-05 NA NA NA hsa-miR-106b-5p COL4A3 1.07509411417907 2.11739194181878e-36 -2.55706680336115 7.46423081113932e-30 MirTarget;miRNATAP -1.16645399237856 1.65634845691786e-17 NA NA NA hsa-miR-126-5p COL4A3 0.785607261431085 5.77058629454465e-13 -2.55706680336115 7.46423081113932e-30 mirMAP -0.415073372912069 0.000592794392439501 NA NA NA hsa-miR-140-5p COL4A3 0.504309496243674 3.09884038729031e-11 -2.55706680336115 7.46423081113932e-30 miRanda -0.923651948171001 1.0724446333838e-07 NA NA NA hsa-miR-142-5p COL4A3 1.88417391525707 1.2096808039882e-27 -2.55706680336115 7.46423081113932e-30 mirMAP -0.663433240539667 1.29172553386542e-22 NA NA NA hsa-miR-146b-5p COL4A3 1.40714170253819 2.9559871816487e-12 -2.55706680336115 7.46423081113932e-30 miRanda -0.579408995838442 4.30346705140373e-21 NA NA NA hsa-miR-15b-3p COL4A3 1.49422666971434 5.44139893275088e-29 -2.55706680336115 7.46423081113932e-30 mirMAP -0.814312185716732 2.88750627992747e-20 NA NA NA hsa-miR-16-2-3p COL4A3 1.3046118743965 4.17207934608428e-19 -2.55706680336115 7.46423081113932e-30 mirMAP -0.658563505195961 8.57246490499886e-15 NA NA NA hsa-miR-17-5p COL4A3 0.494260110870015 3.8348005261e-09 -2.55706680336115 7.46423081113932e-30 MirTarget;TargetScan;miRNATAP -0.887648623780081 1.76016069327087e-08 NA NA NA hsa-miR-186-5p COL4A3 0.507217561043443 9.04455748270995e-10 -2.55706680336115 7.46423081113932e-30 mirMAP -1.31568221235205 1.68224284974649e-17 NA NA NA hsa-miR-193a-3p COL4A3 0.849206638484406 3.68101781083335e-14 -2.55706680336115 7.46423081113932e-30 miRanda -0.953644610292409 1.55471840220467e-17 NA NA NA hsa-miR-195-3p COL4A3 0.808592887366705 6.8151241038711e-09 -2.55706680336115 7.46423081113932e-30 mirMAP -0.291514233653974 0.00248750791045084 NA NA NA hsa-miR-20a-5p COL4A3 0.702602695798242 4.06372887613329e-13 -2.55706680336115 7.46423081113932e-30 MirTarget;miRNATAP -0.497958818378075 0.000252239239170457 NA NA NA hsa-miR-326 COL4A3 0.0283498662828876 0.83943976716391 -2.55706680336115 7.46423081113932e-30 miRanda -0.344487109566754 0.000415369568780023 NA NA NA hsa-miR-330-3p COL4A3 0.912906550436308 3.35037014057665e-13 -2.55706680336115 7.46423081113932e-30 miRNATAP -0.460668943443285 1.52071174510301e-05 NA NA NA hsa-miR-330-5p COL4A3 1.44960468659754 2.12131210588035e-45 -2.55706680336115 7.46423081113932e-30 miRanda -1.2187993529418 8.06199585702464e-31 NA NA NA hsa-miR-374a-5p COL4A3 0.543061152108237 2.19403097299769e-14 -2.55706680336115 7.46423081113932e-30 MirTarget -1.10312856055153 1.6304369908043e-09 NA NA NA hsa-miR-590-3p COL4A3 1.13702599385212 3.53435739887793e-22 -2.55706680336115 7.46423081113932e-30 miRanda -0.799707141173371 2.76937226392031e-14 NA NA NA hsa-miR-625-5p COL4A3 0.153090549230629 0.330314026509869 -2.55706680336115 7.46423081113932e-30 MirTarget -0.460422183335526 7.49526321582273e-07 NA NA NA hsa-miR-7-1-3p COL4A3 0.544601828025304 5.33830451326047e-07 -2.55706680336115 7.46423081113932e-30 MirTarget -0.653695587218332 8.82685626114184e-08 NA NA NA hsa-miR-93-3p COL4A3 0.379664250785728 9.76327751780657e-05 -2.55706680336115 7.46423081113932e-30 miRNATAP -0.80071061048178 5.03087899540544e-09 NA NA NA hsa-miR-93-5p COL4A3 1.37365940377595 2.37567548683245e-46 -2.55706680336115 7.46423081113932e-30 MirTarget;miRNATAP -1.03465152104301 9.46083208552891e-19 NA NA NA hsa-let-7f-1-3p COL4A4 0.477913872379336 4.46669616865068e-05 -2.48226917509733 2.74302690703519e-43 mirMAP -0.49484822579892 1.7112026171175e-06 NA NA NA hsa-miR-130b-3p COL4A4 1.12788913578446 2.939369462276e-16 -2.48226917509733 2.74302690703519e-43 mirMAP -0.788702675049237 1.97370126062341e-27 NA NA NA hsa-miR-142-3p COL4A4 1.88928758773299 2.72985643829893e-22 -2.48226917509733 2.74302690703519e-43 miRanda -0.475441287925603 2.71974906803692e-20 NA NA NA hsa-miR-150-5p COL4A4 1.00371863159681 1.09871676395528e-09 -2.48226917509733 2.74302690703519e-43 miRNATAP -0.363612151628889 4.00136232552817e-08 NA NA NA hsa-miR-155-5p COL4A4 3.26274490570809 5.06841441826518e-51 -2.48226917509733 2.74302690703519e-43 mirMAP -0.542215161133561 3.71077569684135e-44 NA NA NA hsa-miR-15b-3p COL4A4 1.49422666971434 5.44139893275088e-29 -2.48226917509733 2.74302690703519e-43 MirTarget -0.703431193074769 7.65197782431028e-22 NA NA NA hsa-miR-16-5p COL4A4 0.934012514027655 4.85417898318515e-24 -2.48226917509733 2.74302690703519e-43 mirMAP -0.982060736060291 2.17239140412632e-19 NA NA NA hsa-miR-181a-2-3p COL4A4 0.549613348249471 1.48987286432989e-10 -2.48226917509733 2.74302690703519e-43 MirTarget -0.534264529909361 3.56017542697036e-05 NA NA NA hsa-miR-186-5p COL4A4 0.507217561043443 9.04455748270995e-10 -2.48226917509733 2.74302690703519e-43 mirMAP -1.01108518219088 7.50935792122239e-15 NA NA NA hsa-miR-224-3p COL4A4 0.918780460857403 2.47005991706282e-07 -2.48226917509733 2.74302690703519e-43 mirMAP -0.214933043367626 0.000918294945334735 NA NA NA hsa-miR-23a-3p COL4A4 0.761438723382355 4.09310879199257e-27 -2.48226917509733 2.74302690703519e-43 miRNATAP -1.11096780935801 1.53356753653898e-14 NA NA NA hsa-miR-301a-3p COL4A4 0.259400847075798 0.0216890736701418 -2.48226917509733 2.74302690703519e-43 mirMAP -0.495600726262727 6.67303357254365e-07 NA NA NA hsa-miR-454-3p COL4A4 0.68285296887698 1.17407812677787e-08 -2.48226917509733 2.74302690703519e-43 mirMAP -0.629214742338623 3.46741472165424e-12 NA NA NA hsa-miR-576-5p COL4A4 1.06681109513983 5.69294424466526e-24 -2.48226917509733 2.74302690703519e-43 PITA -0.870067194540466 4.94598888968244e-20 NA NA NA hsa-miR-590-3p COL4A4 1.13702599385212 3.53435739887793e-22 -2.48226917509733 2.74302690703519e-43 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.860311348019649 3.35243570629448e-24 NA NA NA hsa-miR-629-3p COL4A4 1.09330044556689 2.9533160808356e-14 -2.48226917509733 2.74302690703519e-43 MirTarget;miRNATAP -0.512199697966219 9.35496068624353e-12 NA NA NA hsa-let-7b-5p COL4A5 0.770868211539597 6.63408323707647e-21 -3.02863037241735 3.56080057014188e-44 miRNATAP -1.09215359147954 1.27575423059332e-12 NA NA NA hsa-let-7i-5p COL4A5 0.911372377723717 7.11483853341932e-31 -3.02863037241735 3.56080057014188e-44 miRNATAP -0.999512910568258 1.61924171999484e-10 NA NA NA hsa-miR-146b-5p COL4A5 1.40714170253819 2.9559871816487e-12 -3.02863037241735 3.56080057014188e-44 miRanda -0.335850819120768 2.42220251910098e-07 NA NA NA hsa-miR-193a-3p COL4A5 0.849206638484406 3.68101781083335e-14 -3.02863037241735 3.56080057014188e-44 miRanda -0.536587545194828 4.94415489202178e-06 NA NA NA hsa-miR-23a-3p COL4A5 0.761438723382355 4.09310879199257e-27 -3.02863037241735 3.56080057014188e-44 miRNATAP -1.1217459447236 2.68341924393353e-10 NA NA NA hsa-miR-330-3p COL4A5 0.912906550436308 3.35037014057665e-13 -3.02863037241735 3.56080057014188e-44 PITA -0.556940394608914 1.86365497041804e-07 NA NA NA hsa-miR-338-5p COL4A5 0.628429807914222 1.27575140717947e-06 -3.02863037241735 3.56080057014188e-44 PITA;miRNATAP -0.362044523434853 0.000676765118405363 NA NA NA hsa-miR-455-5p COL4A5 0.773674551205946 2.12957541541474e-09 -3.02863037241735 3.56080057014188e-44 miRanda -0.593909809414485 6.30870880708222e-09 NA NA NA hsa-miR-590-3p COL4A5 1.13702599385212 3.53435739887793e-22 -3.02863037241735 3.56080057014188e-44 miRanda;mirMAP -0.832389325200846 3.65654201231978e-15 NA NA NA hsa-miR-197-3p COL4A6 0.297760714271229 0.00102679606305048 -6.29481533861811 8.25004065584084e-83 miRNAWalker2_validate -0.730008888782232 0.00456490207980432 NA NA NA hsa-miR-330-5p COL4A6 1.44960468659754 2.12131210588035e-45 -6.29481533861811 8.25004065584084e-83 miRanda -2.19505039667714 4.51693750546496e-35 NA NA NA hsa-miR-342-3p COL4A6 1.4124432570595 1.07208971556131e-28 -6.29481533861811 8.25004065584084e-83 miRanda -1.70775103921877 1.58031616228602e-28 NA NA NA hsa-miR-590-3p COL4A6 1.13702599385212 3.53435739887793e-22 -6.29481533861811 8.25004065584084e-83 miRanda -1.82600245177178 2.90665356019013e-26 NA NA NA hsa-let-7e-5p COL6A1 -0.727009689927955 1.30690859412163e-11 0.962979987920018 4.71887556332576e-13 miRNAWalker2_validate -0.276004189688158 5.69272865481135e-05 NA NA NA hsa-miR-10a-5p COL6A2 -1.17164272592931 4.86621098042279e-24 1.87594917872349 2.0995684314935e-26 miRNAWalker2_validate -0.63842896690357 5.13683973159565e-15 NA NA NA hsa-miR-10b-5p COL6A2 -0.89971464210447 1.18190532299934e-20 1.87594917872349 2.0995684314935e-26 miRNAWalker2_validate -0.571350460086774 1.84958291171703e-08 NA NA NA hsa-miR-29c-3p COL6A3 -0.238671318446745 0.0141475322347596 1.06724769903491 7.39257628260306e-08 MirTarget;miRNATAP -0.689227726823409 9.62463431932681e-10 NA NA NA hsa-miR-362-3p COL6A3 -0.753214251798232 3.0025661608035e-07 1.06724769903491 7.39257628260306e-08 miRanda -0.356686396451349 2.88049096903058e-06 NA NA NA hsa-miR-429 COL6A3 -2.16569233119434 2.66862243626443e-37 1.06724769903491 7.39257628260306e-08 miRNATAP -0.514353779137527 1.00696736631569e-20 NA NA NA hsa-miR-146b-5p COL9A1 1.40714170253819 2.9559871816487e-12 -0.689218192385549 0.00904877410233412 miRanda;miRNATAP -0.405541437664963 3.25887225054759e-09 NA NA NA hsa-miR-29b-3p COL9A1 -0.228125979913806 0.0271621721891603 -0.689218192385549 0.00904877410233412 miRNATAP -0.595851042253301 2.40206055231565e-05 NA NA NA hsa-miR-590-3p COL9A1 1.13702599385212 3.53435739887793e-22 -0.689218192385549 0.00904877410233412 miRanda -0.38492645938822 0.000964847104729952 NA NA NA hsa-miR-7-1-3p COL9A1 0.544601828025304 5.33830451326047e-07 -0.689218192385549 0.00904877410233412 mirMAP -0.459847516383246 0.000519873291267953 NA NA NA hsa-miR-18a-5p COL9A2 0.936704393213466 1.05064580570579e-10 -2.9557468156559 2.81329962731727e-35 MirTarget -0.302863995524602 0.00210218611846056 NA NA NA hsa-miR-486-5p COL9A3 1.16748143760361 1.68410465883829e-08 -2.15064434948467 1.12968547219055e-15 miRanda -0.251742093262932 0.000567969413829561 NA NA NA hsa-miR-590-3p COL9A3 1.13702599385212 3.53435739887793e-22 -2.15064434948467 1.12968547219055e-15 miRanda -0.465331797530927 0.000164476736416663 NA NA NA hsa-miR-106b-5p CREB1 1.07509411417907 2.11739194181878e-36 -0.0655642661330038 0.279893677218175 MirTarget -0.108161307293289 0.00199171380124524 NA NA NA hsa-miR-22-3p CREB1 0.198460552200729 0.00761005672059428 -0.0655642661330038 0.279893677218175 MirTarget -0.166392891714343 0.000218760004013248 NA NA NA hsa-miR-338-5p CREB3L1 0.628429807914222 1.27575140717947e-06 -1.07581854941085 2.15750016655846e-05 MirTarget;PITA;miRNATAP -0.348229203788248 0.00145383640111072 NA NA NA hsa-miR-106b-5p CREB3L2 1.07509411417907 2.11739194181878e-36 -0.310973753478538 5.17428383021473e-06 mirMAP -0.236669251309294 1.53697106990172e-09 NA NA NA hsa-miR-181a-5p CREB3L2 1.11111114875339 3.97880443756442e-29 -0.310973753478538 5.17428383021473e-06 mirMAP -0.172048561186244 7.30974790598101e-07 NA NA NA hsa-miR-181b-5p CREB3L2 1.49054296272357 3.69051660739368e-41 -0.310973753478538 5.17428383021473e-06 mirMAP -0.145359245805576 1.10316134940392e-06 NA NA NA hsa-miR-181c-5p CREB3L2 0.762784646696248 4.48373118147729e-10 -0.310973753478538 5.17428383021473e-06 mirMAP -0.105254622149687 0.000497168690667054 NA NA NA hsa-miR-19b-3p CREB3L2 0.195940928879427 0.0300512922542325 -0.310973753478538 5.17428383021473e-06 miRNAWalker2_validate -0.146927125169408 0.000505892980671622 NA NA NA hsa-miR-20a-5p CREB3L2 0.702602695798242 4.06372887613329e-13 -0.310973753478538 5.17428383021473e-06 mirMAP -0.168726181768274 7.56095361311143e-06 NA NA NA hsa-miR-2355-3p CREB3L2 1.32757890426926 1.88016636795886e-18 -0.310973753478538 5.17428383021473e-06 mirMAP -0.107434914619007 8.80649873053256e-06 NA NA NA hsa-miR-24-3p CREB3L2 0.173813044685099 0.00565259443420961 -0.310973753478538 5.17428383021473e-06 miRNATAP -0.208505557995053 0.000691135960205571 NA NA NA hsa-miR-32-5p CREB3L2 0.407826130035097 7.26884631998646e-06 -0.310973753478538 5.17428383021473e-06 MirTarget;miRNATAP -0.168969563695234 4.32663010942657e-05 NA NA NA hsa-miR-361-5p CREB3L2 0.0514169367202078 0.382929376393199 -0.310973753478538 5.17428383021473e-06 miRanda -0.254837989187097 0.000110730269884509 NA NA NA hsa-miR-374b-5p CREB3L2 0.0804104684417872 0.365593963035077 -0.310973753478538 5.17428383021473e-06 mirMAP -0.142324900640949 0.000965469767645304 NA NA NA hsa-miR-199a-5p CREB3L3 -1.64658415208633 1.01615659358973e-23 3.83604195830867 1.10347161393744e-19 mirMAP -0.870725617773606 2.02893458942746e-10 NA NA NA hsa-miR-199b-5p CREB3L3 -2.39483476763681 1.04659509514884e-17 3.83604195830867 1.10347161393744e-19 mirMAP -0.519312681808119 6.04396616290309e-10 NA NA NA hsa-miR-106a-5p CREB5 -0.830908656792615 2.67547872901508e-10 1.58281909757317 1.5043262479149e-30 MirTarget;miRNATAP -0.167472630436677 0.00687738144771455 NA NA NA hsa-miR-10a-3p CREB5 -1.40380922426511 3.42207767326254e-23 1.58281909757317 1.5043262479149e-30 mirMAP -0.414097008441144 2.34356591827232e-14 NA NA NA hsa-miR-10a-5p CREB5 -1.17164272592931 4.86621098042279e-24 1.58281909757317 1.5043262479149e-30 miRNAWalker2_validate -0.521037218907789 5.72446079944921e-16 NA NA NA hsa-miR-125a-5p CREB5 -0.561874059994802 7.3931856356891e-13 1.58281909757317 1.5043262479149e-30 miRNAWalker2_validate -0.353836717465383 0.000653720196369034 NA NA NA hsa-miR-141-3p CREB5 -5.87110686537457 1.20877726722907e-85 1.58281909757317 1.5043262479149e-30 mirMAP -0.224422139891812 2.7836194724978e-30 NA NA NA hsa-miR-182-5p CREB5 -0.608710746044567 0.0025264935278104 1.58281909757317 1.5043262479149e-30 mirMAP -0.120796149353211 0.00338707877702173 NA NA NA hsa-miR-200a-3p CREB5 -1.43409013664263 2.00188483717828e-20 1.58281909757317 1.5043262479149e-30 mirMAP -0.140417326662729 0.0057003486716183 NA NA NA hsa-miR-200b-3p CREB5 -1.70383252137161 2.38979336321755e-30 1.58281909757317 1.5043262479149e-30 TargetScan -0.260804964667191 2.29301529155648e-07 NA NA NA hsa-miR-200c-3p CREB5 -5.40303134829523 2.74173143360645e-94 1.58281909757317 1.5043262479149e-30 miRNATAP -0.239672061339815 1.06494539751851e-27 NA NA NA hsa-miR-20b-5p CREB5 -1.30218163823367 6.87172815978149e-17 1.58281909757317 1.5043262479149e-30 MirTarget;miRNATAP -0.214437082890484 2.35351007520109e-05 NA NA NA hsa-miR-218-5p CREB5 -0.81077534785501 3.0631582201951e-08 1.58281909757317 1.5043262479149e-30 mirMAP -0.329731826232599 1.75271987125921e-09 NA NA NA hsa-miR-29a-3p CREB5 -0.431613225927952 4.10166815070288e-08 1.58281909757317 1.5043262479149e-30 MirTarget;miRNATAP -0.664113532658713 9.9812604464643e-11 NA NA NA hsa-miR-29b-3p CREB5 -0.228125979913806 0.0271621721891603 1.58281909757317 1.5043262479149e-30 MirTarget;miRNATAP -0.244278522582721 0.00264228177148838 NA NA NA hsa-miR-29c-3p CREB5 -0.238671318446745 0.0141475322347596 1.58281909757317 1.5043262479149e-30 MirTarget;miRNATAP -0.223298179331398 0.00977892465376975 NA NA NA hsa-miR-3065-3p CREB5 -1.64500070417457 9.57561660036697e-16 1.58281909757317 1.5043262479149e-30 miRNATAP -0.144926589763886 0.000184305858524874 NA NA NA hsa-miR-30a-3p CREB5 -0.955360819934585 1.97009535429185e-20 1.58281909757317 1.5043262479149e-30 mirMAP -0.234523258645537 0.00217315129837539 NA NA NA hsa-miR-30b-3p CREB5 -1.64703050862226 1.89878531036464e-31 1.58281909757317 1.5043262479149e-30 MirTarget -0.427765649990435 1.24876189451655e-16 NA NA NA hsa-miR-335-3p CREB5 -1.36498175550207 6.84287752180534e-13 1.58281909757317 1.5043262479149e-30 mirMAP -0.219661634349004 1.50232711081334e-07 NA NA NA hsa-miR-362-3p CREB5 -0.753214251798232 3.0025661608035e-07 1.58281909757317 1.5043262479149e-30 PITA -0.287555548195798 4.42729558788626e-07 NA NA NA hsa-miR-362-5p CREB5 -2.72767654824605 1.34821749679113e-49 1.58281909757317 1.5043262479149e-30 PITA -0.326497158556448 6.83452590890899e-19 NA NA NA hsa-miR-381-3p CREB5 -0.674906433524392 0.000234722307243307 1.58281909757317 1.5043262479149e-30 mirMAP -0.136715561635848 0.00270594949422158 NA NA NA hsa-miR-429 CREB5 -2.16569233119434 2.66862243626443e-37 1.58281909757317 1.5043262479149e-30 PITA;miRanda;miRNATAP -0.23399564123929 5.65300047811461e-08 NA NA NA hsa-miR-500a-5p CREB5 -1.28374735824553 1.95870374809798e-20 1.58281909757317 1.5043262479149e-30 mirMAP -0.277350448011525 7.94312264739337e-07 NA NA NA hsa-miR-532-3p CREB5 -1.759223962964 7.9077916669414e-40 1.58281909757317 1.5043262479149e-30 miRNATAP -0.365845218944708 1.11391534017098e-11 NA NA NA hsa-miR-577 CREB5 -1.48881999472397 7.03080165111147e-10 1.58281909757317 1.5043262479149e-30 PITA;mirMAP;miRNATAP -0.157631950913702 2.50006591530241e-06 NA NA NA hsa-miR-766-3p CREB5 -0.230617949950715 0.0566289375252083 1.58281909757317 1.5043262479149e-30 MirTarget -0.217917710206543 0.00163547016771415 NA NA NA hsa-miR-9-5p CREB5 -2.23538606210968 1.28143998950751e-12 1.58281909757317 1.5043262479149e-30 miRNATAP -0.10461150296437 3.73615118438343e-05 NA NA NA hsa-miR-125a-5p CSF1 -0.561874059994802 7.3931856356891e-13 0.828310197763411 2.57624161736929e-12 mirMAP -0.395873885403413 1.93692599708895e-06 NA NA NA hsa-miR-125b-5p CSF1 -0.825456421494266 2.13029877878434e-15 0.828310197763411 2.57624161736929e-12 mirMAP -0.218814994226492 0.000431474889918609 NA NA NA hsa-miR-149-5p CSF1 -1.95790336710741 8.46371715052367e-27 0.828310197763411 2.57624161736929e-12 MirTarget -0.135160675559984 6.55594095962956e-05 NA NA NA hsa-miR-20b-5p CSF1 -1.30218163823367 6.87172815978149e-17 0.828310197763411 2.57624161736929e-12 miRNATAP -0.143821877341533 0.000474036707352673 NA NA NA hsa-miR-27b-3p CSF1 -0.699527231242518 1.07356023759234e-15 0.828310197763411 2.57624161736929e-12 MirTarget;miRNATAP -0.317604540220119 1.76268674972506e-05 NA NA NA hsa-miR-30b-5p CSF1 -1.18330589477119 6.8341618466966e-27 0.828310197763411 2.57624161736929e-12 miRNAWalker2_validate -0.368050287582893 2.28262327368113e-11 NA NA NA hsa-miR-30c-5p CSF1 -1.08783070774238 2.02505402525786e-24 0.828310197763411 2.57624161736929e-12 miRNAWalker2_validate -0.336765548240368 5.7885490297714e-09 NA NA NA hsa-miR-429 CSF1 -2.16569233119434 2.66862243626443e-37 0.828310197763411 2.57624161736929e-12 PITA;miRanda;miRNATAP -0.223344874996782 9.46209764511635e-11 NA NA NA hsa-miR-532-3p CSF1 -1.759223962964 7.9077916669414e-40 0.828310197763411 2.57624161736929e-12 MirTarget;PITA -0.306939151835304 1.5169200994507e-12 NA NA NA hsa-miR-532-5p CSF1 -1.09700348358668 8.34836230254408e-26 0.828310197763411 2.57624161736929e-12 miRNATAP -0.431387311083581 8.94844012284901e-14 NA NA NA hsa-miR-127-3p CSF3R -1.21389348740811 1.68387193137287e-11 2.90015123900884 1.37521986016231e-51 miRanda -0.216558952743924 0.00118112179597598 NA NA NA hsa-miR-30b-3p CSF3R -1.64703050862226 1.89878531036464e-31 2.90015123900884 1.37521986016231e-51 MirTarget -0.847675078615151 8.44876867014225e-31 NA NA NA hsa-miR-429 CSF3R -2.16569233119434 2.66862243626443e-37 2.90015123900884 1.37521986016231e-51 miRanda -0.505655126350947 6.12163686496989e-16 NA NA NA hsa-miR-139-5p DDIT4 -0.704802495091118 2.36904108453776e-06 2.16368662998061 1.54601166495436e-45 MirTarget;miRanda;miRNATAP -0.212811288105503 0.000902260884977072 NA NA NA hsa-miR-199a-3p DDIT4 -1.61607426368083 1.97964980193147e-26 2.16368662998061 1.54601166495436e-45 MirTarget;PITA;miRNATAP -0.337054174457861 5.83494287354051e-09 NA NA NA hsa-miR-199b-3p DDIT4 -1.61804389801139 1.97668652730486e-26 2.16368662998061 1.54601166495436e-45 MirTarget;PITA;miRNATAP -0.336916890699972 5.66409102514339e-09 NA NA NA hsa-miR-200b-3p DDIT4 -1.70383252137161 2.38979336321755e-30 2.16368662998061 1.54601166495436e-45 TargetScan -0.476340538893359 4.84816173724126e-17 NA NA NA hsa-miR-30a-5p DDIT4 -0.778411951775343 2.73322451127932e-16 2.16368662998061 1.54601166495436e-45 MirTarget;miRNATAP -0.874614457328679 2.64517397122604e-21 NA NA NA hsa-miR-30b-5p DDIT4 -1.18330589477119 6.8341618466966e-27 2.16368662998061 1.54601166495436e-45 MirTarget -0.68641210192901 6.65570416737091e-19 NA NA NA hsa-miR-30c-5p DDIT4 -1.08783070774238 2.02505402525786e-24 2.16368662998061 1.54601166495436e-45 MirTarget;miRNATAP -0.747016684812148 1.0629513734135e-20 NA NA NA hsa-miR-30d-5p DDIT4 -0.202727675788184 0.00659067084745794 2.16368662998061 1.54601166495436e-45 MirTarget;miRNATAP -0.606513462309504 3.34569724594775e-06 NA NA NA hsa-miR-30e-5p DDIT4 -0.0905907245198101 0.21196704484334 2.16368662998061 1.54601166495436e-45 MirTarget -0.611793244511632 5.86163301562435e-06 NA NA NA hsa-miR-429 DDIT4 -2.16569233119434 2.66862243626443e-37 2.16368662998061 1.54601166495436e-45 miRanda;miRNATAP -0.440511070839646 5.89408931873978e-20 NA NA NA hsa-miR-615-3p DDIT4 -0.777370544471479 2.08193713560545e-08 2.16368662998061 1.54601166495436e-45 miRNAWalker2_validate -0.196993602165312 0.00417018557659908 NA NA NA hsa-miR-199a-5p EFNA1 -1.64658415208633 1.01615659358973e-23 1.14383470621964 1.8843101516825e-20 miRanda -0.185373862936427 5.10111326697694e-06 NA NA NA hsa-miR-200b-3p EFNA1 -1.70383252137161 2.38979336321755e-30 1.14383470621964 1.8843101516825e-20 MirTarget;TargetScan -0.134966695411153 0.00228373190081269 NA NA NA hsa-miR-200c-3p EFNA1 -5.40303134829523 2.74173143360645e-94 1.14383470621964 1.8843101516825e-20 MirTarget;miRNATAP -0.181458532224935 1.2414606354021e-20 23065816 G A variant in miR 200c binding site of EFNA1 alters susceptibility to gastric cancer; Furthermore luciferase assays indicated EFNA1 as the target of hsa-miR-200c and rs12904 G > A change resulted in altered regulation of luciferase expression; Taken together these findings indicate that the miR-200c binding site SNP rs12904 G > A in the 3'UTR of EFNA1 can modulate EFNA1 expression and is associated with GC susceptibility gastric cancer hsa-miR-218-5p EFNA1 -0.81077534785501 3.0631582201951e-08 1.14383470621964 1.8843101516825e-20 miRNAWalker2_validate -0.167931355386355 0.000510592026626917 NA NA NA hsa-miR-30c-2-3p EFNA1 -1.28402709024345 6.77577627955178e-25 1.14383470621964 1.8843101516825e-20 MirTarget -0.283203639137564 9.62713819380543e-08 NA NA NA hsa-miR-324-3p EFNA1 -0.197662887871899 0.0298845059559819 1.14383470621964 1.8843101516825e-20 MirTarget;miRNATAP -0.438782043719366 2.65562302115535e-08 NA NA NA hsa-miR-335-5p EFNA1 -2.09515619961552 1.03765771499548e-25 1.14383470621964 1.8843101516825e-20 miRNAWalker2_validate -0.196438057726134 2.87933792785959e-09 NA NA NA hsa-miR-429 EFNA1 -2.16569233119434 2.66862243626443e-37 1.14383470621964 1.8843101516825e-20 MirTarget;PITA;miRanda;miRNATAP -0.13824050077292 0.000253644840903669 NA NA NA hsa-miR-491-5p EFNA1 -0.0898777415179634 0.533906535063567 1.14383470621964 1.8843101516825e-20 miRanda -0.146002082800429 0.00565137630060931 NA NA NA hsa-miR-96-5p EFNA1 -1.00223771166604 3.91564621567028e-06 1.14383470621964 1.8843101516825e-20 TargetScan -0.135031708537988 6.09037321028163e-05 NA NA NA hsa-miR-127-5p EFNA3 -1.33574359249785 5.73079880594981e-13 2.11061761081172 2.25783858294686e-44 PITA;miRNATAP -0.201615514388474 4.60899700091898e-05 NA NA NA hsa-miR-27b-3p EFNA3 -0.699527231242518 1.07356023759234e-15 2.11061761081172 2.25783858294686e-44 miRNATAP -0.628093568778092 1.30371688902415e-09 NA NA NA hsa-miR-30a-5p EFNA3 -0.778411951775343 2.73322451127932e-16 2.11061761081172 2.25783858294686e-44 MirTarget;mirMAP;miRNATAP -0.790764383259196 8.28517926023966e-18 NA NA NA hsa-miR-30b-5p EFNA3 -1.18330589477119 6.8341618466966e-27 2.11061761081172 2.25783858294686e-44 MirTarget;mirMAP -0.568614214193418 2.31510429385467e-13 NA NA NA hsa-miR-30c-5p EFNA3 -1.08783070774238 2.02505402525786e-24 2.11061761081172 2.25783858294686e-44 MirTarget;mirMAP;miRNATAP -0.674780052378266 2.73310713398252e-17 NA NA NA hsa-miR-30d-5p EFNA3 -0.202727675788184 0.00659067084745794 2.11061761081172 2.25783858294686e-44 MirTarget;mirMAP;miRNATAP -0.496216413934784 0.000122770761203762 NA NA NA hsa-miR-30e-5p EFNA3 -0.0905907245198101 0.21196704484334 2.11061761081172 2.25783858294686e-44 MirTarget;mirMAP -0.568298340264734 1.99551027034849e-05 NA NA NA hsa-miR-324-3p EFNA3 -0.197662887871899 0.0298845059559819 2.11061761081172 2.25783858294686e-44 MirTarget;PITA;miRNATAP -0.418443594951789 7.47362308436019e-05 NA NA NA hsa-miR-493-5p EFNA3 -1.03936667688502 3.71842205277243e-08 2.11061761081172 2.25783858294686e-44 MirTarget;miRNATAP -0.140694301737607 0.00617298880450261 NA NA NA hsa-miR-101-3p EFNA5 0.683973909682285 2.88573524246948e-15 -0.916153638664415 0.000753557067438735 miRNATAP -1.30644299979948 4.85092098666961e-16 NA NA NA hsa-miR-204-5p EFNA5 -1.67490789640238 9.14741888352476e-10 -0.916153638664415 0.000753557067438735 miRNATAP -0.453398164832293 4.85524883001676e-19 NA NA NA hsa-miR-28-5p EFNA5 0.461962042257226 3.32424690573327e-11 -0.916153638664415 0.000753557067438735 PITA;miRNATAP -0.774365773387412 0.000272291161753875 NA NA NA hsa-miR-338-3p EFNA5 0.906250377628867 2.76970900371139e-15 -0.916153638664415 0.000753557067438735 miRanda;miRNATAP -0.459437884692377 0.000261404591982066 NA NA NA hsa-miR-378a-3p EFNA5 0.287244802401236 0.0501155019984562 -0.916153638664415 0.000753557067438735 miRNATAP -0.407239578295669 7.00744079160358e-05 NA NA NA hsa-miR-378c EFNA5 0.755048315231594 3.56147090439556e-06 -0.916153638664415 0.000753557067438735 miRNATAP -0.455006523654393 5.8522084831463e-07 NA NA NA hsa-miR-421 EFNA5 0.313155739887734 0.020433534776003 -0.916153638664415 0.000753557067438735 mirMAP -0.309719389996976 0.00735760679037501 NA NA NA hsa-miR-592 EFNA5 2.6404220268798 8.81369998128794e-32 -0.916153638664415 0.000753557067438735 mirMAP;miRNATAP -0.197937206739904 0.0011674086024969 NA NA NA hsa-miR-590-3p EGF 1.13702599385212 3.53435739887793e-22 -6.49821423238405 1.01144352508784e-64 miRanda -1.60204014811855 6.03930462045536e-16 NA NA NA hsa-miR-629-3p EGF 1.09330044556689 2.9533160808356e-14 -6.49821423238405 1.01144352508784e-64 miRNATAP -0.695727142965681 6.88083628515494e-05 NA NA NA hsa-miR-141-3p EGFR -5.87110686537457 1.20877726722907e-85 1.04566425778521 6.25371695782468e-12 MirTarget -0.142272170209372 5.89271101342102e-11 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-188-5p EGFR -1.74586655806628 1.50431624674552e-28 1.04566425778521 6.25371695782468e-12 mirMAP -0.266112483430454 2.11374456409575e-07 NA NA NA hsa-miR-199a-3p EGFR -1.61607426368083 1.97964980193147e-26 1.04566425778521 6.25371695782468e-12 mirMAP -0.201778068439938 0.000117100162581278 NA NA NA hsa-miR-199b-3p EGFR -1.61804389801139 1.97668652730486e-26 1.04566425778521 6.25371695782468e-12 mirMAP -0.201560537599491 0.000116841770931786 NA NA NA hsa-miR-27b-3p EGFR -0.699527231242518 1.07356023759234e-15 1.04566425778521 6.25371695782468e-12 MirTarget;miRNATAP -0.42975046882661 5.91405803681307e-06 NA NA NA hsa-miR-335-5p EGFR -2.09515619961552 1.03765771499548e-25 1.04566425778521 6.25371695782468e-12 miRNAWalker2_validate -0.130866439253699 0.00119751239304092 NA NA NA hsa-miR-362-5p EGFR -2.72767654824605 1.34821749679113e-49 1.04566425778521 6.25371695782468e-12 mirMAP -0.275325520610269 1.67616170773246e-12 NA NA NA hsa-miR-375 EGFR -1.46468479447701 9.20596529469647e-07 1.04566425778521 6.25371695782468e-12 miRanda -0.116635350053781 3.88231671031593e-05 NA NA NA hsa-miR-501-5p EGFR -1.1103073934745 1.81589804886553e-16 1.04566425778521 6.25371695782468e-12 mirMAP -0.351439828127429 5.20411928127982e-09 NA NA NA hsa-miR-654-3p EGFR -1.07948413911035 1.47901771988248e-07 1.04566425778521 6.25371695782468e-12 mirMAP -0.119137373119274 0.00494226674362834 NA NA NA hsa-miR-107 EIF4B 0.140046250553248 0.0943611632552367 0.265754888221512 0.000370911774075073 MirTarget;PITA;miRanda;miRNATAP -0.14866857828035 0.00288697258013526 NA NA NA hsa-miR-193b-3p EIF4B -0.273325765316079 0.104328826585392 0.265754888221512 0.000370911774075073 miRNAWalker2_validate -0.136557854642932 1.52060087619542e-08 NA NA NA hsa-miR-362-3p EIF4B -0.753214251798232 3.0025661608035e-07 0.265754888221512 0.000370911774075073 miRanda -0.163643050529037 4.95060472748533e-09 NA NA NA hsa-miR-429 EIF4B -2.16569233119434 2.66862243626443e-37 0.265754888221512 0.000370911774075073 miRanda;miRNATAP -0.102106541707063 1.88308160319094e-06 NA NA NA hsa-miR-532-3p EIF4B -1.759223962964 7.9077916669414e-40 0.265754888221512 0.000370911774075073 miRNATAP -0.134641880766081 6.6316836635778e-07 NA NA NA hsa-miR-126-5p EIF4E 0.785607261431085 5.77058629454465e-13 -0.592879162769574 2.23429360171169e-21 mirMAP -0.114986360293591 0.00038593683116203 NA NA NA hsa-miR-130b-3p EIF4E 1.12788913578446 2.939369462276e-16 -0.592879162769574 2.23429360171169e-21 mirMAP -0.130010254109064 2.01796960128932e-07 NA NA NA hsa-miR-142-5p EIF4E 1.88417391525707 1.2096808039882e-27 -0.592879162769574 2.23429360171169e-21 mirMAP -0.111938152052401 4.09257842023961e-09 NA NA NA hsa-miR-155-5p EIF4E 3.26274490570809 5.06841441826518e-51 -0.592879162769574 2.23429360171169e-21 mirMAP -0.104934553217022 3.01434690576764e-14 NA NA NA hsa-miR-15b-3p EIF4E 1.49422666971434 5.44139893275088e-29 -0.592879162769574 2.23429360171169e-21 mirMAP -0.135490489574837 4.02015267504856e-08 NA NA NA hsa-miR-16-5p EIF4E 0.934012514027655 4.85417898318515e-24 -0.592879162769574 2.23429360171169e-21 miRNAWalker2_validate -0.158076464262536 1.72109439890791e-05 NA NA NA hsa-miR-17-5p EIF4E 0.494260110870015 3.8348005261e-09 -0.592879162769574 2.23429360171169e-21 TargetScan -0.115319011434752 0.00741006427249683 NA NA NA hsa-miR-186-5p EIF4E 0.507217561043443 9.04455748270995e-10 -0.592879162769574 2.23429360171169e-21 mirMAP -0.137758645095685 0.00152481785154887 NA NA NA hsa-miR-25-3p EIF4E 1.12016166564779 3.79069348635778e-48 -0.592879162769574 2.23429360171169e-21 mirMAP -0.290037744966355 3.98867157436052e-13 NA NA NA hsa-miR-28-3p EIF4E 1.01277915413238 1.8655970171461e-43 -0.592879162769574 2.23429360171169e-21 mirMAP -0.296755213866688 3.87555840248158e-12 NA NA NA hsa-miR-32-5p EIF4E 0.407826130035097 7.26884631998646e-06 -0.592879162769574 2.23429360171169e-21 mirMAP -0.125399937975617 0.00172975997413774 NA NA NA hsa-miR-320a EIF4E 0.412740558379182 2.02929519701706e-05 -0.592879162769574 2.23429360171169e-21 MirTarget;miRanda -0.140662497263495 0.000172851537500746 NA NA NA hsa-miR-338-3p EIF4E 0.906250377628867 2.76970900371139e-15 -0.592879162769574 2.23429360171169e-21 miRanda -0.100364539022003 0.00102659122467453 NA NA NA hsa-miR-340-3p EIF4E 0.916396642224413 1.53096840464699e-18 -0.592879162769574 2.23429360171169e-21 MirTarget -0.127397339965355 0.000128165195724909 NA NA NA hsa-miR-374a-3p EIF4E 1.13863935833993 2.79089304015401e-44 -0.592879162769574 2.23429360171169e-21 mirMAP -0.267327634367235 2.48263922300642e-12 NA NA NA hsa-miR-374a-5p EIF4E 0.543061152108237 2.19403097299769e-14 -0.592879162769574 2.23429360171169e-21 mirMAP -0.141913765427639 0.00465001877160016 NA NA NA hsa-miR-452-5p EIF4E 2.05325688842141 2.82238393643084e-40 -0.592879162769574 2.23429360171169e-21 mirMAP -0.11908864870098 5.96862385610994e-09 NA NA NA hsa-miR-576-5p EIF4E 1.06681109513983 5.69294424466526e-24 -0.592879162769574 2.23429360171169e-21 mirMAP -0.15850130232059 6.89734673484199e-07 NA NA NA hsa-miR-590-3p EIF4E 1.13702599385212 3.53435739887793e-22 -0.592879162769574 2.23429360171169e-21 miRanda;mirMAP -0.121009922785523 3.15347765276384e-05 NA NA NA hsa-miR-7-1-3p EIF4E 0.544601828025304 5.33830451326047e-07 -0.592879162769574 2.23429360171169e-21 MirTarget -0.122486342429634 0.000220649147997829 NA NA NA hsa-miR-769-5p EIF4E 0.376837385738096 4.45440414144944e-07 -0.592879162769574 2.23429360171169e-21 miRNAWalker2_validate -0.175959571774459 0.000303054662693615 NA NA NA hsa-miR-92b-3p EIF4E 0.418630595140165 6.50466149211154e-05 -0.592879162769574 2.23429360171169e-21 mirMAP -0.130569488601578 0.000161347956190744 NA NA NA hsa-miR-125a-5p EIF4EBP1 -0.561874059994802 7.3931856356891e-13 1.80123929586267 2.12304033084494e-30 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.693130609645124 2.50560481498786e-09 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ovarian cancer hsa-miR-125b-5p EIF4EBP1 -0.825456421494266 2.13029877878434e-15 1.80123929586267 2.12304033084494e-30 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.328703334871537 0.000176754185174443 17891175;26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ; prostate cancer;ovarian cancer hsa-miR-874-3p EIF4EBP1 -1.50243370621573 8.39418307315909e-25 1.80123929586267 2.12304033084494e-30 MirTarget -0.573633359130349 2.31880892116845e-24 NA NA NA hsa-miR-193b-3p EPHA2 -0.273325765316079 0.104328826585392 0.368959129772177 0.00490074756518361 miRNAWalker2_validate -0.237291440313046 2.14068577455112e-08 NA NA NA hsa-miR-362-3p EPO -0.753214251798232 3.0025661608035e-07 2.97468115359073 2.48151362453116e-09 miRanda -0.817311050765461 2.37811083324868e-05 NA NA NA hsa-miR-29a-5p F2R -0.519003718107105 1.03351148282116e-06 0.665180287491714 3.07074351513448e-07 MirTarget -0.236228244681994 0.000482416871223735 NA NA NA hsa-miR-429 F2R -2.16569233119434 2.66862243626443e-37 0.665180287491714 3.07074351513448e-07 miRanda -0.282716251353881 1.45063373651907e-14 NA NA NA hsa-miR-577 F2R -1.48881999472397 7.03080165111147e-10 0.665180287491714 3.07074351513448e-07 MirTarget;miRNATAP -0.14105205619468 1.33292688525694e-06 NA NA NA hsa-let-7e-5p FASLG -0.727009689927955 1.30690859412163e-11 3.49526870659822 3.0591043026913e-47 miRNATAP -0.956759956622149 2.07254587441987e-12 NA NA NA hsa-let-7g-5p FASLG -0.739744008507763 1.07979566264383e-14 3.49526870659822 3.0591043026913e-47 miRNATAP -0.527566684352497 0.00071592111786537 NA NA NA hsa-miR-199a-5p FASLG -1.64658415208633 1.01615659358973e-23 3.49526870659822 3.0591043026913e-47 miRanda -0.587327373538791 5.90733830602172e-12 NA NA NA hsa-miR-362-3p FASLG -0.753214251798232 3.0025661608035e-07 3.49526870659822 3.0591043026913e-47 miRanda -0.346233134453532 0.00119742349456323 NA NA NA hsa-miR-126-5p FGF1 0.785607261431085 5.77058629454465e-13 -3.80115931488584 6.45925676739727e-49 mirMAP -0.412699157217257 0.00526602775124141 NA NA NA hsa-miR-146b-3p FGF1 1.20941495066078 2.12939149602665e-10 -3.80115931488584 6.45925676739727e-49 miRNATAP -0.412681804700488 8.7577650210875e-07 NA NA NA hsa-miR-16-1-3p FGF1 1.51429140700091 3.17219833254498e-37 -3.80115931488584 6.45925676739727e-49 mirMAP -0.964767375204906 2.41440232347677e-15 NA NA NA hsa-miR-186-5p FGF1 0.507217561043443 9.04455748270995e-10 -3.80115931488584 6.45925676739727e-49 mirMAP -1.1691556044543 1.5936381390255e-09 NA NA NA hsa-miR-18a-5p FGF1 0.936704393213466 1.05064580570579e-10 -3.80115931488584 6.45925676739727e-49 MirTarget -0.380773292559268 0.00062635862331619 NA NA NA hsa-miR-193a-3p FGF1 0.849206638484406 3.68101781083335e-14 -3.80115931488584 6.45925676739727e-49 PITA -0.799485713529985 1.34176070169954e-08 NA NA NA hsa-miR-21-5p FGF1 2.51462371613332 3.30620591950316e-66 -3.80115931488584 6.45925676739727e-49 MirTarget -1.0333718022015 1.64441254488335e-35 NA NA NA hsa-miR-2355-5p FGF1 1.57515081110162 3.54962327490702e-48 -3.80115931488584 6.45925676739727e-49 MirTarget -1.06613568021987 4.20053987792956e-17 NA NA NA hsa-miR-28-5p FGF1 0.461962042257226 3.32424690573327e-11 -3.80115931488584 6.45925676739727e-49 miRanda -0.947270161202561 5.17246250727041e-05 NA NA NA hsa-miR-320a FGF1 0.412740558379182 2.02929519701706e-05 -3.80115931488584 6.45925676739727e-49 miRanda -0.542494284439551 0.00150132216990968 NA NA NA hsa-miR-330-5p FGF1 1.44960468659754 2.12131210588035e-45 -3.80115931488584 6.45925676739727e-49 miRanda;miRNATAP -1.30237436907411 7.22656393944219e-23 NA NA NA hsa-miR-374a-3p FGF1 1.13863935833993 2.79089304015401e-44 -3.80115931488584 6.45925676739727e-49 mirMAP -1.40971713192021 1.79713277496189e-16 NA NA NA hsa-miR-3913-5p FGF1 0.136365354811444 0.24239516424369 -3.80115931488584 6.45925676739727e-49 mirMAP -0.458269193077043 0.00234831890309927 NA NA NA hsa-miR-484 FGF1 0.571987778099603 9.67278224458421e-10 -3.80115931488584 6.45925676739727e-49 MirTarget;PITA;miRNATAP -0.539151528053616 0.00200972026686984 NA NA NA hsa-miR-550a-5p FGF1 0.764341426122997 7.62129848116256e-09 -3.80115931488584 6.45925676739727e-49 MirTarget -0.542780642335613 1.80477226060982e-05 NA NA NA hsa-miR-576-5p FGF1 1.06681109513983 5.69294424466526e-24 -3.80115931488584 6.45925676739727e-49 PITA;mirMAP -1.26887442737172 6.80528442258741e-20 NA NA NA hsa-miR-590-5p FGF1 0.709763558412506 1.11883921359361e-11 -3.80115931488584 6.45925676739727e-49 MirTarget;miRanda;miRNATAP -0.760247687860989 6.80195819553776e-07 NA NA NA hsa-miR-629-5p FGF1 1.73389921851483 5.39614356468007e-48 -3.80115931488584 6.45925676739727e-49 MirTarget -1.38540287626161 3.01408249241889e-38 NA NA NA hsa-let-7e-5p FGF11 -0.727009689927955 1.30690859412163e-11 2.23617192158805 1.8788982620777e-26 mirMAP;miRNATAP -0.32446922393154 0.00441188606836517 NA NA NA hsa-let-7g-5p FGF11 -0.739744008507763 1.07979566264383e-14 2.23617192158805 1.8788982620777e-26 mirMAP;miRNATAP -0.714675969532457 9.32950813786375e-09 NA NA NA hsa-miR-10a-5p FGF11 -1.17164272592931 4.86621098042279e-24 2.23617192158805 1.8788982620777e-26 mirMAP -0.519537627190446 1.90326383611477e-07 NA NA NA hsa-miR-125a-5p FGF11 -0.561874059994802 7.3931856356891e-13 2.23617192158805 1.8788982620777e-26 mirMAP -0.491473322603107 0.00168737579895867 NA NA NA hsa-miR-125b-5p FGF11 -0.825456421494266 2.13029877878434e-15 2.23617192158805 1.8788982620777e-26 mirMAP -0.790229628434622 2.28241804372165e-12 NA NA NA hsa-miR-193b-3p FGF11 -0.273325765316079 0.104328826585392 2.23617192158805 1.8788982620777e-26 miRNAWalker2_validate -0.264997262620483 0.000378170532610284 NA NA NA hsa-miR-199a-5p FGF11 -1.64658415208633 1.01615659358973e-23 2.23617192158805 1.8788982620777e-26 miRanda -0.365321328288127 2.0503722571563e-07 NA NA NA hsa-miR-199b-5p FGF11 -2.39483476763681 1.04659509514884e-17 2.23617192158805 1.8788982620777e-26 miRanda -0.267087192579251 3.70589364602002e-10 NA NA NA hsa-miR-217 FGF11 -1.32414431829977 4.20138196453017e-06 2.23617192158805 1.8788982620777e-26 PITA;miRanda -0.217410327744056 3.17577593872614e-07 NA NA NA hsa-miR-324-5p FGF11 -0.487750893426456 3.74472736457965e-05 2.23617192158805 1.8788982620777e-26 miRanda -0.440327954994482 2.67066434439899e-05 NA NA NA hsa-miR-335-5p FGF11 -2.09515619961552 1.03765771499548e-25 2.23617192158805 1.8788982620777e-26 miRNAWalker2_validate;mirMAP -0.361050653609898 2.98033784759218e-10 NA NA NA hsa-miR-532-3p FGF11 -1.759223962964 7.9077916669414e-40 2.23617192158805 1.8788982620777e-26 mirMAP -0.722489323765386 5.00428763930247e-20 NA NA NA hsa-miR-107 FGF12 0.140046250553248 0.0943611632552367 -0.544326533476572 0.000268476484930876 miRanda -0.308318107900707 0.0020791655765071 NA NA NA hsa-miR-142-5p FGF12 1.88417391525707 1.2096808039882e-27 -0.544326533476572 0.000268476484930876 miRNATAP -0.318634287216316 6.22273374967518e-14 NA NA NA hsa-miR-17-5p FGF12 0.494260110870015 3.8348005261e-09 -0.544326533476572 0.000268476484930876 TargetScan -0.263868289343099 0.00688746603358349 NA NA NA hsa-miR-2355-3p FGF12 1.32757890426926 1.88016636795886e-18 -0.544326533476572 0.000268476484930876 MirTarget;miRNATAP -0.153811131758858 0.00389207620799374 NA NA NA hsa-miR-342-3p FGF12 1.4124432570595 1.07208971556131e-28 -0.544326533476572 0.000268476484930876 miRanda -0.356290596206616 1.17638486726232e-09 NA NA NA hsa-miR-455-5p FGF12 0.773674551205946 2.12957541541474e-09 -0.544326533476572 0.000268476484930876 miRanda -0.253534570625561 4.85862913572717e-05 NA NA NA hsa-miR-576-5p FGF12 1.06681109513983 5.69294424466526e-24 -0.544326533476572 0.000268476484930876 mirMAP -0.242190473439388 0.000932815704136755 NA NA NA hsa-miR-590-3p FGF12 1.13702599385212 3.53435739887793e-22 -0.544326533476572 0.000268476484930876 mirMAP -0.41088644924644 2.2750931713891e-10 NA NA NA hsa-miR-616-5p FGF12 0.913426384742148 3.78418389333709e-09 -0.544326533476572 0.000268476484930876 MirTarget -0.148821746829177 0.00515708784404577 NA NA NA hsa-miR-142-5p FGF13 1.88417391525707 1.2096808039882e-27 -0.355285378300594 0.0111820560270456 PITA -0.114950681929534 0.00514428395065014 NA NA NA hsa-miR-340-5p FGF13 1.14479851941741 2.91936881701444e-15 -0.355285378300594 0.0111820560270456 MirTarget -0.187712863175925 0.000225631107920348 NA NA NA hsa-miR-455-5p FGF13 0.773674551205946 2.12957541541474e-09 -0.355285378300594 0.0111820560270456 PITA;miRanda -0.213004300489336 0.000261097737029612 NA NA NA hsa-miR-7-1-3p FGF13 0.544601828025304 5.33830451326047e-07 -0.355285378300594 0.0111820560270456 MirTarget;mirMAP -0.279000874186576 6.71817165068062e-05 NA NA NA hsa-miR-103a-3p FGF18 0.779373475434461 7.37867196796994e-20 -1.06341529740156 1.38965890583684e-07 miRNATAP -0.447891739165942 0.00037020775263271 NA NA NA hsa-miR-107 FGF18 0.140046250553248 0.0943611632552367 -1.06341529740156 1.38965890583684e-07 miRNATAP -0.57929754380422 2.05446408358056e-05 NA NA NA hsa-miR-15a-5p FGF18 1.42663930007845 1.36006952074963e-57 -1.06341529740156 1.38965890583684e-07 miRNATAP -0.534405765807597 4.02497295632232e-07 NA NA NA hsa-miR-16-5p FGF18 0.934012514027655 4.85417898318515e-24 -1.06341529740156 1.38965890583684e-07 miRNATAP -0.347307673451457 0.00249430704083827 NA NA NA hsa-miR-21-5p FGF18 2.51462371613332 3.30620591950316e-66 -1.06341529740156 1.38965890583684e-07 miRNATAP -0.240173567040242 0.000131541472622255 NA NA NA hsa-miR-330-5p FGF18 1.44960468659754 2.12131210588035e-45 -1.06341529740156 1.38965890583684e-07 PITA;miRanda;miRNATAP -0.339622639535814 0.000407996785668723 NA NA NA hsa-miR-421 FGF18 0.313155739887734 0.020433534776003 -1.06341529740156 1.38965890583684e-07 miRanda -0.270977518576723 0.00177389655223298 NA NA NA hsa-miR-590-5p FGF18 0.709763558412506 1.11883921359361e-11 -1.06341529740156 1.38965890583684e-07 miRanda;miRNATAP -0.299844534788332 0.00454562101475503 NA NA NA hsa-let-7a-3p FGF2 0.0677487960013088 0.460458477653989 -0.589674911482514 4.9097503791125e-05 mirMAP -0.413855026311993 2.64122269531956e-06 NA NA NA hsa-miR-107 FGF2 0.140046250553248 0.0943611632552367 -0.589674911482514 4.9097503791125e-05 MirTarget;PITA;miRanda;miRNATAP -0.252364961790113 0.00988319837104476 NA NA NA hsa-miR-146a-5p FGF2 1.04938133739924 7.51013231709992e-12 -0.589674911482514 4.9097503791125e-05 mirMAP -0.210539194206361 3.35191542749017e-05 NA NA NA hsa-miR-15a-5p FGF2 1.42663930007845 1.36006952074963e-57 -0.589674911482514 4.9097503791125e-05 MirTarget;miRNATAP -0.255449530855187 0.000776459741728151 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 1.49422666971434 5.44139893275088e-29 -0.589674911482514 4.9097503791125e-05 mirMAP -0.216697138822269 8.55843255884349e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 1.51429140700091 3.17219833254498e-37 -0.589674911482514 4.9097503791125e-05 mirMAP -0.163232052977134 0.00821869739056501 NA NA NA hsa-miR-16-2-3p FGF2 1.3046118743965 4.17207934608428e-19 -0.589674911482514 4.9097503791125e-05 mirMAP -0.186446224772941 0.000351536882101309 NA NA NA hsa-miR-16-5p FGF2 0.934012514027655 4.85417898318515e-24 -0.589674911482514 4.9097503791125e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.242955350739253 0.00300895920388753 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-192-5p FGF2 0.442478872410106 0.0669238175123954 -0.589674911482514 4.9097503791125e-05 miRNAWalker2_validate -0.102614170997363 0.00212550043678563 NA NA NA hsa-miR-19b-1-5p FGF2 0.66692013055553 1.55789130176287e-09 -0.589674911482514 4.9097503791125e-05 mirMAP -0.213543395777736 0.00295255172655819 NA NA NA hsa-miR-21-5p FGF2 2.51462371613332 3.30620591950316e-66 -0.589674911482514 4.9097503791125e-05 mirMAP -0.126618960975775 0.00490413708016251 NA NA NA hsa-miR-215-5p FGF2 1.57223951497888 6.18833867819653e-10 -0.589674911482514 4.9097503791125e-05 miRNAWalker2_validate -0.15555129616708 3.63011104027706e-07 NA NA NA hsa-miR-32-5p FGF2 0.407826130035097 7.26884631998646e-06 -0.589674911482514 4.9097503791125e-05 miRNAWalker2_validate -0.39260283335843 7.71884095801517e-06 NA NA NA hsa-miR-338-5p FGF2 0.628429807914222 1.27575140717947e-06 -0.589674911482514 4.9097503791125e-05 mirMAP -0.215263032074881 0.000575910517976575 NA NA NA hsa-miR-361-5p FGF2 0.0514169367202078 0.382929376393199 -0.589674911482514 4.9097503791125e-05 mirMAP -0.372320972807354 0.00839299302616162 NA NA NA hsa-miR-374a-3p FGF2 1.13863935833993 2.79089304015401e-44 -0.589674911482514 4.9097503791125e-05 mirMAP -0.301198297479784 0.0005177785699223 NA NA NA hsa-miR-374b-5p FGF2 0.0804104684417872 0.365593963035077 -0.589674911482514 4.9097503791125e-05 mirMAP -0.414924088923791 5.30808312664893e-06 NA NA NA hsa-miR-590-3p FGF2 1.13702599385212 3.53435739887793e-22 -0.589674911482514 4.9097503791125e-05 miRanda;mirMAP -0.223542377598034 0.000531270043941063 NA NA NA hsa-miR-590-5p FGF2 0.709763558412506 1.11883921359361e-11 -0.589674911482514 4.9097503791125e-05 miRanda;mirMAP -0.262470036573759 0.000472851744537926 NA NA NA hsa-miR-338-3p FGF5 0.906250377628867 2.76970900371139e-15 -1.83723658792888 9.61171733928648e-07 miRanda -0.523502317862385 0.00291245665472794 NA NA NA hsa-miR-455-5p FGF5 0.773674551205946 2.12957541541474e-09 -1.83723658792888 9.61171733928648e-07 miRanda -0.445706621017696 0.00510035663278383 NA NA NA hsa-miR-126-5p FGF7 0.785607261431085 5.77058629454465e-13 -1.97624310317764 2.86806708934501e-20 miRNATAP -0.35417145796188 0.00148560446741828 NA NA NA hsa-miR-155-5p FGF7 3.26274490570809 5.06841441826518e-51 -1.97624310317764 2.86806708934501e-20 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.209194847453416 1.86189427308698e-05 NA NA NA hsa-miR-15a-5p FGF7 1.42663930007845 1.36006952074963e-57 -1.97624310317764 2.86806708934501e-20 miRTarBase;miRNATAP -0.847236705144023 1.19914061552758e-13 NA NA NA hsa-miR-15b-5p FGF7 0.773001494057531 1.71784656078957e-16 -1.97624310317764 2.86806708934501e-20 miRNATAP -0.675844673945504 9.2634659069312e-08 NA NA NA hsa-miR-16-1-3p FGF7 1.51429140700091 3.17219833254498e-37 -1.97624310317764 2.86806708934501e-20 mirMAP -0.479652584917845 3.96398023440139e-07 NA NA NA hsa-miR-16-2-3p FGF7 1.3046118743965 4.17207934608428e-19 -1.97624310317764 2.86806708934501e-20 mirMAP -0.22562888615642 0.00555719154096863 NA NA NA hsa-miR-16-5p FGF7 0.934012514027655 4.85417898318515e-24 -1.97624310317764 2.86806708934501e-20 miRNATAP -0.562305081893864 8.31032538296145e-06 NA NA NA hsa-miR-20a-5p FGF7 0.702602695798242 4.06372887613329e-13 -1.97624310317764 2.86806708934501e-20 miRNAWalker2_validate -0.56349110002559 6.1764049927491e-06 NA NA NA hsa-miR-27a-3p FGF7 0.558934437526245 1.44256383086177e-12 -1.97624310317764 2.86806708934501e-20 MirTarget -0.491043390020319 0.00156230248699803 NA NA NA hsa-miR-340-5p FGF7 1.14479851941741 2.91936881701444e-15 -1.97624310317764 2.86806708934501e-20 mirMAP -0.369328887879201 7.08248065738976e-06 NA NA NA hsa-miR-374a-3p FGF7 1.13863935833993 2.79089304015401e-44 -1.97624310317764 2.86806708934501e-20 miRNATAP -0.593508361010668 9.50745159268841e-06 NA NA NA hsa-miR-452-5p FGF7 2.05325688842141 2.82238393643084e-40 -1.97624310317764 2.86806708934501e-20 mirMAP -0.373676554420803 1.20947812660623e-07 NA NA NA hsa-miR-455-3p FGF7 0.171798655137046 0.261841668213493 -1.97624310317764 2.86806708934501e-20 PITA;miRNATAP -0.304968993458052 0.00019698398945574 NA NA NA hsa-miR-486-5p FGF7 1.16748143760361 1.68410465883829e-08 -1.97624310317764 2.86806708934501e-20 MirTarget;miRanda -0.214937151224756 0.000278538413773526 NA NA NA hsa-miR-542-3p FGF7 0.431147917094433 0.000254981247606435 -1.97624310317764 2.86806708934501e-20 miRanda -0.315059448630938 0.00298991790572798 NA NA NA hsa-miR-590-3p FGF7 1.13702599385212 3.53435739887793e-22 -1.97624310317764 2.86806708934501e-20 PITA;miRanda;mirMAP;miRNATAP -0.368850958190117 0.000229960701103488 NA NA NA hsa-miR-590-5p FGF7 0.709763558412506 1.11883921359361e-11 -1.97624310317764 2.86806708934501e-20 PITA;miRanda -0.348010220978055 0.00292627950694944 NA NA NA hsa-miR-616-5p FGF7 0.913426384742148 3.78418389333709e-09 -1.97624310317764 2.86806708934501e-20 mirMAP -0.298120733208393 0.000201559767102017 NA NA NA hsa-miR-7-1-3p FGF7 0.544601828025304 5.33830451326047e-07 -1.97624310317764 2.86806708934501e-20 mirMAP -0.43572294285412 0.000128343842961541 NA NA NA hsa-miR-132-3p FGF9 0.291409674711894 0.000912684337101876 -7.89303410861971 6.51626529576473e-68 mirMAP -1.49278300216127 2.05673100310755e-05 NA NA NA hsa-miR-140-3p FGF9 0.989350547007025 6.14964028267239e-25 -7.89303410861971 6.51626529576473e-68 miRNATAP -2.36734754388086 1.68509808638843e-16 NA NA NA hsa-miR-140-5p FGF9 0.504309496243674 3.09884038729031e-11 -7.89303410861971 6.51626529576473e-68 miRNAWalker2_validate;PITA;miRanda;miRNATAP -2.14696810755974 4.91581299417391e-08 NA NA NA hsa-miR-142-3p FGF9 1.88928758773299 2.72985643829893e-22 -7.89303410861971 6.51626529576473e-68 miRanda -1.28510812329466 4.80178741191123e-20 NA NA NA hsa-miR-142-5p FGF9 1.88417391525707 1.2096808039882e-27 -7.89303410861971 6.51626529576473e-68 mirMAP -1.5849190428124 2.31403871037857e-25 NA NA NA hsa-miR-143-3p FGF9 0.544259011512089 1.71102635165867e-05 -7.89303410861971 6.51626529576473e-68 miRNATAP -0.918749044179476 0.000137890724045419 NA NA NA hsa-miR-155-5p FGF9 3.26274490570809 5.06841441826518e-51 -7.89303410861971 6.51626529576473e-68 miRNATAP -1.45574467015398 9.91351979840903e-43 NA NA NA hsa-miR-15a-5p FGF9 1.42663930007845 1.36006952074963e-57 -7.89303410861971 6.51626529576473e-68 miRNATAP -3.59565285580255 6.46550650472585e-46 NA NA NA hsa-miR-15b-5p FGF9 0.773001494057531 1.71784656078957e-16 -7.89303410861971 6.51626529576473e-68 miRNATAP -2.62381325572957 2.49932882811215e-18 NA NA NA hsa-miR-16-2-3p FGF9 1.3046118743965 4.17207934608428e-19 -7.89303410861971 6.51626529576473e-68 mirMAP -1.47968858497529 1.56368473036667e-14 NA NA NA hsa-miR-16-5p FGF9 0.934012514027655 4.85417898318515e-24 -7.89303410861971 6.51626529576473e-68 miRNATAP -2.93941999209394 8.19865698545329e-24 NA NA NA hsa-miR-181a-5p FGF9 1.11111114875339 3.97880443756442e-29 -7.89303410861971 6.51626529576473e-68 mirMAP -3.01683259489948 6.2935151356822e-31 NA NA NA hsa-miR-181b-5p FGF9 1.49054296272357 3.69051660739368e-41 -7.89303410861971 6.51626529576473e-68 mirMAP -2.88764658364589 2.42529744328292e-40 NA NA NA hsa-miR-181c-5p FGF9 0.762784646696248 4.48373118147729e-10 -7.89303410861971 6.51626529576473e-68 mirMAP -0.974034125284438 7.24711889757936e-05 NA NA NA hsa-miR-186-5p FGF9 0.507217561043443 9.04455748270995e-10 -7.89303410861971 6.51626529576473e-68 mirMAP -2.38550261599293 2.61095557708383e-11 NA NA NA hsa-miR-195-3p FGF9 0.808592887366705 6.8151241038711e-09 -7.89303410861971 6.51626529576473e-68 mirMAP;miRNATAP -1.1840868478066 3.6353294065925e-08 NA NA NA hsa-miR-195-5p FGF9 0.346502644882604 0.0092562828415903 -7.89303410861971 6.51626529576473e-68 miRNATAP -0.834949314691814 0.000307067445099101 NA NA NA hsa-miR-320a FGF9 0.412740558379182 2.02929519701706e-05 -7.89303410861971 6.51626529576473e-68 mirMAP;miRNATAP -1.74376828066047 2.39519261181127e-08 NA NA NA hsa-miR-320b FGF9 0.300497419754843 0.0245219177384172 -7.89303410861971 6.51626529576473e-68 mirMAP;miRNATAP -0.829189781584702 0.000327781913785607 NA NA NA hsa-miR-330-5p FGF9 1.44960468659754 2.12131210588035e-45 -7.89303410861971 6.51626529576473e-68 miRanda;miRNATAP -3.09466572534346 1.25369400690336e-40 NA NA NA hsa-miR-338-3p FGF9 0.906250377628867 2.76970900371139e-15 -7.89303410861971 6.51626529576473e-68 PITA;miRanda;miRNATAP -1.75095892002454 3.06094850352792e-12 NA NA NA hsa-miR-338-5p FGF9 0.628429807914222 1.27575140717947e-06 -7.89303410861971 6.51626529576473e-68 miRNATAP -1.18083105634736 6.1007334937809e-07 NA NA NA hsa-miR-374a-5p FGF9 0.543061152108237 2.19403097299769e-14 -7.89303410861971 6.51626529576473e-68 mirMAP -3.20984621216012 2.95766906510555e-15 NA NA NA hsa-miR-450b-5p FGF9 0.404819502355575 0.00357671373841274 -7.89303410861971 6.51626529576473e-68 mirMAP;miRNATAP -0.585609878563624 0.00843223916148081 NA NA NA hsa-miR-455-5p FGF9 0.773674551205946 2.12957541541474e-09 -7.89303410861971 6.51626529576473e-68 miRanda -2.01014500445414 1.06761241000351e-19 NA NA NA hsa-miR-486-5p FGF9 1.16748143760361 1.68410465883829e-08 -7.89303410861971 6.51626529576473e-68 miRanda;miRNATAP -0.665125032723195 4.27507860555687e-06 NA NA NA hsa-miR-590-3p FGF9 1.13702599385212 3.53435739887793e-22 -7.89303410861971 6.51626529576473e-68 miRanda;mirMAP -2.01793594346917 1.06482309489454e-17 NA NA NA hsa-miR-590-5p FGF9 0.709763558412506 1.11883921359361e-11 -7.89303410861971 6.51626529576473e-68 miRanda -1.77139537220211 2.97618057411205e-10 NA NA NA hsa-miR-106a-5p FGFR1 -0.830908656792615 2.67547872901508e-10 -0.0525238824904433 0.558795583881832 mirMAP -0.122312677751729 0.000796948557217005 NA NA NA hsa-miR-106b-5p FGFR1 1.07509411417907 2.11739194181878e-36 -0.0525238824904433 0.558795583881832 mirMAP -0.172801838537576 0.000867031520570411 NA NA NA hsa-miR-15a-5p FGFR1 1.42663930007845 1.36006952074963e-57 -0.0525238824904433 0.558795583881832 miRNATAP -0.155174390546639 0.0008156091626643 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 0.934012514027655 4.85417898318515e-24 -0.0525238824904433 0.558795583881832 miRTarBase;miRNATAP -0.147661895787119 0.00311233392470522 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-200a-5p FGFR1 -1.36295040293874 1.31587720312419e-22 -0.0525238824904433 0.558795583881832 mirMAP -0.11714731259483 0.000383511996434836 NA NA NA hsa-miR-455-5p FGFR1 0.773674551205946 2.12957541541474e-09 -0.0525238824904433 0.558795583881832 miRanda -0.135338346114823 0.000273762518549006 NA NA NA hsa-miR-744-5p FGFR1 -0.348985243196771 0.000187889982228835 -0.0525238824904433 0.558795583881832 miRNAWalker2_validate -0.146388006709524 0.00556141272629985 NA NA NA hsa-miR-93-5p FGFR1 1.37365940377595 2.37567548683245e-46 -0.0525238824904433 0.558795583881832 mirMAP -0.12587058194249 0.00478965048434933 NA NA NA hsa-let-7f-1-3p FGFR2 0.477913872379336 4.46669616865068e-05 -1.51421563934131 8.18226435279308e-18 mirMAP -0.459956632895475 7.61285152724438e-07 NA NA NA hsa-miR-107 FGFR2 0.140046250553248 0.0943611632552367 -1.51421563934131 8.18226435279308e-18 PITA;miRanda -0.437925872253477 0.000383864151891506 NA NA NA hsa-miR-146b-5p FGFR2 1.40714170253819 2.9559871816487e-12 -1.51421563934131 8.18226435279308e-18 miRanda -0.195329005140458 6.1791587336115e-05 NA NA NA hsa-miR-186-5p FGFR2 0.507217561043443 9.04455748270995e-10 -1.51421563934131 8.18226435279308e-18 miRNAWalker2_validate -0.658270917605348 3.90698190892792e-08 NA NA NA hsa-miR-193a-3p FGFR2 0.849206638484406 3.68101781083335e-14 -1.51421563934131 8.18226435279308e-18 miRanda -0.301820482762674 0.000602194355705739 NA NA NA hsa-miR-19b-1-5p FGFR2 0.66692013055553 1.55789130176287e-09 -1.51421563934131 8.18226435279308e-18 miRNAWalker2_validate;miRTarBase -0.282031805724181 0.00192425817708402 NA NA NA hsa-miR-330-5p FGFR2 1.44960468659754 2.12131210588035e-45 -1.51421563934131 8.18226435279308e-18 miRanda -0.664891022598281 1.62616877464583e-15 NA NA NA hsa-miR-338-3p FGFR2 0.906250377628867 2.76970900371139e-15 -1.51421563934131 8.18226435279308e-18 miRanda;miRNATAP -0.293371462535014 0.000601750978017947 NA NA NA hsa-miR-423-3p FGFR2 0.460506077888547 3.44680149368459e-09 -1.51421563934131 8.18226435279308e-18 PITA;miRNATAP -0.489761504946408 0.000152390546115974 NA NA NA hsa-miR-590-3p FGFR2 1.13702599385212 3.53435739887793e-22 -1.51421563934131 8.18226435279308e-18 miRanda -0.563054904471333 1.30676539898336e-12 NA NA NA hsa-miR-100-5p FGFR3 0.11286733449117 0.464055070627288 -0.904654482736578 8.36824652739321e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.313875417771344 2.1395862881888e-06 25344675;26604796;26018508;23778527 MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3;Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress ;;;poor survival pancreatic cancer;glioblastoma;sarcoma;bladder cancer hsa-miR-142-3p FGFR3 1.88928758773299 2.72985643829893e-22 -0.904654482736578 8.36824652739321e-07 miRanda -0.280059637101442 7.39044053762073e-09 NA NA NA hsa-miR-19a-3p FGFR3 0.722913586880779 2.76301458932381e-10 -0.904654482736578 8.36824652739321e-07 mirMAP -0.264260219813925 0.00257802543229013 NA NA NA hsa-miR-590-3p FGFR3 1.13702599385212 3.53435739887793e-22 -0.904654482736578 8.36824652739321e-07 miRanda -0.407978649398992 5.16183297718401e-07 NA NA NA hsa-miR-106a-5p FLT1 -0.830908656792615 2.67547872901508e-10 1.81517574635769 1.10448835983217e-26 MirTarget;miRNATAP -0.419583167151917 1.42259707146721e-08 NA NA NA hsa-miR-10a-5p FLT1 -1.17164272592931 4.86621098042279e-24 1.81517574635769 1.10448835983217e-26 miRNATAP -0.360911769443886 8.55461520244007e-06 NA NA NA hsa-miR-149-5p FLT1 -1.95790336710741 8.46371715052367e-27 1.81517574635769 1.10448835983217e-26 MirTarget -0.399959935574143 3.74282493289576e-16 NA NA NA hsa-miR-200b-3p FLT1 -1.70383252137161 2.38979336321755e-30 1.81517574635769 1.10448835983217e-26 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.400501248620924 3.76845913581599e-11 21115742 Forced miR-200 expression suppressed Flt1 levels in metastasis-prone lung adenocarcinoma cells derived from K-ras/p53-mutant mice and negatively regulated the Flt1 3'-UTR in reporter assays; We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1 metastasis;tumorigenesis lung cancer hsa-miR-200c-3p FLT1 -5.40303134829523 2.74173143360645e-94 1.81517574635769 1.10448835983217e-26 miRNAWalker2_validate;miRTarBase;MirTarget -0.304428126244817 1.44888713983443e-30 NA NA NA hsa-miR-20b-5p FLT1 -1.30218163823367 6.87172815978149e-17 1.81517574635769 1.10448835983217e-26 MirTarget;miRNATAP -0.393971858847136 7.87802197069509e-11 NA NA NA hsa-miR-22-5p FLT1 -0.197038086012602 0.106234828461117 1.81517574635769 1.10448835983217e-26 MirTarget -0.487561865206754 2.71190099492294e-09 NA NA NA hsa-miR-29a-5p FLT1 -0.519003718107105 1.03351148282116e-06 1.81517574635769 1.10448835983217e-26 MirTarget -0.586299743971952 2.26338228021702e-10 NA NA NA hsa-miR-335-3p FLT1 -1.36498175550207 6.84287752180534e-13 1.81517574635769 1.10448835983217e-26 mirMAP -0.337519735728676 1.81513836278812e-11 NA NA NA hsa-miR-429 FLT1 -2.16569233119434 2.66862243626443e-37 1.81517574635769 1.10448835983217e-26 MirTarget;miRanda;miRNATAP -0.33754297250473 8.14366131336631e-11 NA NA NA hsa-miR-501-5p FLT1 -1.1103073934745 1.81589804886553e-16 1.81517574635769 1.10448835983217e-26 mirMAP -0.483930077905975 4.19503456488762e-12 NA NA NA hsa-miR-664a-5p FLT1 -0.618481839889218 7.01961389909184e-09 1.81517574635769 1.10448835983217e-26 MirTarget -0.421272532785725 5.42268477509845e-06 NA NA NA hsa-miR-874-3p FLT1 -1.50243370621573 8.39418307315909e-25 1.81517574635769 1.10448835983217e-26 MirTarget -0.352663167390114 2.72717237789663e-08 NA NA NA hsa-miR-125a-5p FLT3 -0.561874059994802 7.3931856356891e-13 0.610289767826127 0.0244691370210934 miRanda -0.740480916419243 6.60726191896486e-05 NA NA NA hsa-miR-335-5p FLT3 -2.09515619961552 1.03765771499548e-25 0.610289767826127 0.0244691370210934 miRNAWalker2_validate -0.221140926861003 0.00154374486820464 NA NA NA hsa-miR-199b-5p FLT4 -2.39483476763681 1.04659509514884e-17 1.02779259814417 7.24979598797067e-13 miRanda -0.142746235017119 3.55749364034554e-07 NA NA NA hsa-miR-429 FLT4 -2.16569233119434 2.66862243626443e-37 1.02779259814417 7.24979598797067e-13 miRanda;miRNATAP -0.204415836765987 1.46840427271399e-06 NA NA NA hsa-let-7g-5p FN1 -0.739744008507763 1.07979566264383e-14 1.7020002762399 2.74776700571101e-22 miRTarBase -0.347640287912278 0.000840211036349235 NA NA NA hsa-miR-139-5p FN1 -0.704802495091118 2.36904108453776e-06 1.7020002762399 2.74776700571101e-22 miRanda -0.236785162994945 0.00051355462200661 NA NA NA hsa-miR-200b-3p FN1 -1.70383252137161 2.38979336321755e-30 1.7020002762399 2.74776700571101e-22 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.576806526520913 2.49007139556473e-22 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-200c-3p FN1 -5.40303134829523 2.74173143360645e-94 1.7020002762399 2.74776700571101e-22 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.254959275555693 7.0639277027511e-20 NA NA NA hsa-miR-27b-3p FN1 -0.699527231242518 1.07356023759234e-15 1.7020002762399 2.74776700571101e-22 MirTarget -0.927919258785755 1.54644351248372e-17 NA NA NA hsa-miR-429 FN1 -2.16569233119434 2.66862243626443e-37 1.7020002762399 2.74776700571101e-22 MirTarget;PITA;miRanda;miRNATAP -0.525964902364629 1.34120335286919e-25 NA NA NA hsa-miR-130b-3p FOXO3 1.12788913578446 2.939369462276e-16 0.0145675585279559 0.841502533713186 mirMAP -0.103348155484141 0.000177371842210912 NA NA NA hsa-miR-221-3p FOXO3 0.337895669520713 0.0136448974691037 0.0145675585279559 0.841502533713186 miRNAWalker2_validate;miRTarBase -0.131475711169287 5.22566111565056e-06 NA NA NA hsa-miR-29a-3p FOXO3 -0.431613225927952 4.10166815070288e-08 0.0145675585279559 0.841502533713186 miRNATAP -0.255922848169364 2.53219341742002e-07 NA NA NA hsa-miR-29a-5p FOXO3 -0.519003718107105 1.03351148282116e-06 0.0145675585279559 0.841502533713186 mirMAP -0.116537531545471 0.00170644733662729 NA NA NA hsa-miR-29b-3p FOXO3 -0.228125979913806 0.0271621721891603 0.0145675585279559 0.841502533713186 miRNATAP -0.200728061711275 1.57505185777375e-07 NA NA NA hsa-miR-361-3p FOXO3 1.08992546227594 1.13197240706704e-36 0.0145675585279559 0.841502533713186 miRNATAP -0.109354015746997 0.00869745649186802 NA NA NA hsa-miR-362-3p FOXO3 -0.753214251798232 3.0025661608035e-07 0.0145675585279559 0.841502533713186 miRanda -0.127162354432933 3.17043126582796e-06 NA NA NA hsa-miR-590-3p FOXO3 1.13702599385212 3.53435739887793e-22 0.0145675585279559 0.841502533713186 PITA;miRanda;mirMAP;miRNATAP -0.104697697759791 0.0010246022148635 NA NA NA hsa-miR-590-5p FOXO3 0.709763558412506 1.11883921359361e-11 0.0145675585279559 0.841502533713186 miRanda -0.140731692565237 0.000142854107904904 NA NA NA hsa-miR-23a-3p G6PC 0.761438723382355 4.09310879199257e-27 -3.48152999844226 2.24139015422197e-14 miRNAWalker2_validate;miRTarBase -1.73590293264897 3.7917402626717e-07 22318941 Stat3 mediated activation of microRNA 23a suppresses gluconeogenesis in hepatocellular carcinoma by down regulating glucose 6 phosphatase and peroxisome proliferator activated receptor gamma coactivator 1 alpha; The expression of microRNA miR-23a a candidate miR targeting PGC-1α and G6PC was up-regulated in the mouse liver tumors as well as in primary human HCC; We confirmed PGC-1α and G6PC as direct targets of miR-23a and their expressions negatively correlated with miR-23a expression in human HCCs; Based on these data we conclude that gluconeogenesis is severely compromised in HCC by IL6-Stat3-mediated activation of miR-23a which directly targets PGC-1α and G6PC leading to decreased glucose production liver cancer hsa-miR-29b-3p G6PC -0.228125979913806 0.0271621721891603 -3.48152999844226 2.24139015422197e-14 MirTarget -0.680199550500983 0.00773886541988953 NA NA NA hsa-miR-330-5p G6PC 1.44960468659754 2.12131210588035e-45 -3.48152999844226 2.24139015422197e-14 miRanda -1.43155203047831 4.10088212185583e-11 NA NA NA hsa-let-7i-5p GHR 0.911372377723717 7.11483853341932e-31 -0.955186227006797 3.69358652414153e-08 miRNATAP -0.726049723887594 5.34447036878994e-11 NA NA NA hsa-miR-142-3p GHR 1.88928758773299 2.72985643829893e-22 -0.955186227006797 3.69358652414153e-08 MirTarget;PITA;miRanda;miRNATAP -0.176030319444075 0.000161318020245714 NA NA NA hsa-miR-15a-5p GHR 1.42663930007845 1.36006952074963e-57 -0.955186227006797 3.69358652414153e-08 MirTarget;miRNATAP -0.453849278577286 5.82863690126066e-07 NA NA NA hsa-miR-15b-5p GHR 0.773001494057531 1.71784656078957e-16 -0.955186227006797 3.69358652414153e-08 MirTarget;miRNATAP -0.478420037004111 1.26392220958e-06 NA NA NA hsa-miR-16-2-3p GHR 1.3046118743965 4.17207934608428e-19 -0.955186227006797 3.69358652414153e-08 mirMAP -0.262146870859392 2.96598397484773e-05 NA NA NA hsa-miR-590-3p GHR 1.13702599385212 3.53435739887793e-22 -0.955186227006797 3.69358652414153e-08 mirMAP -0.446832848188645 5.49046571889865e-09 NA NA NA hsa-miR-651-5p GHR 0.535144061895781 2.49922577209869e-05 -0.955186227006797 3.69358652414153e-08 MirTarget -0.230389461869185 0.00447721652840496 NA NA NA hsa-miR-30b-3p GNB3 -1.64703050862226 1.89878531036464e-31 0.239288600079937 0.309211385629664 MirTarget -0.346008589347179 3.2720172313703e-05 NA NA NA hsa-miR-326 GNB3 0.0283498662828876 0.83943976716391 0.239288600079937 0.309211385629664 miRanda -0.277774570960389 0.00280350951479688 NA NA NA hsa-miR-491-5p GNB3 -0.0898777415179634 0.533906535063567 0.239288600079937 0.309211385629664 miRanda -0.301323222496664 0.00139510124345083 NA NA NA hsa-miR-23b-3p GNB4 -0.533749586990474 2.46924776953771e-10 0.717692744845763 1.31100525221405e-12 mirMAP -0.211940374097266 0.00160357165794238 NA NA NA hsa-miR-27b-3p GNB4 -0.699527231242518 1.07356023759234e-15 0.717692744845763 1.31100525221405e-12 miRNAWalker2_validate -0.427583853172145 4.87387860690263e-12 NA NA NA hsa-miR-29c-3p GNB4 -0.238671318446745 0.0141475322347596 0.717692744845763 1.31100525221405e-12 miRNAWalker2_validate;MirTarget -0.184648551713383 0.00194508201647152 NA NA NA hsa-miR-361-5p GNB4 0.0514169367202078 0.382929376393199 0.717692744845763 1.31100525221405e-12 miRanda;miRNATAP -0.27264099678363 0.00684347057969641 NA NA NA hsa-miR-429 GNB4 -2.16569233119434 2.66862243626443e-37 0.717692744845763 1.31100525221405e-12 miRanda -0.219482046421191 5.39117232314714e-14 NA NA NA hsa-miR-501-5p GNB4 -1.1103073934745 1.81589804886553e-16 0.717692744845763 1.31100525221405e-12 mirMAP -0.190150329553736 2.5700003568722e-06 NA NA NA hsa-miR-130b-3p GNB5 1.12788913578446 2.939369462276e-16 -0.984223544597764 1.38107029018304e-45 miRNAWalker2_validate -0.269344258090407 8.76291599189731e-21 NA NA NA hsa-miR-148a-3p GNB5 0.343233211643815 0.00402279073598165 -0.984223544597764 1.38107029018304e-45 miRNAWalker2_validate -0.120319940242345 0.001103302523172 NA NA NA hsa-miR-17-5p GNB5 0.494260110870015 3.8348005261e-09 -0.984223544597764 1.38107029018304e-45 TargetScan -0.320310422806991 2.46355902549298e-10 NA NA NA hsa-miR-27a-3p GNB5 0.558934437526245 1.44256383086177e-12 -0.984223544597764 1.38107029018304e-45 miRNAWalker2_validate -0.409679443373698 5.39689522339972e-15 NA NA NA hsa-miR-338-3p GNB5 0.906250377628867 2.76970900371139e-15 -0.984223544597764 1.38107029018304e-45 miRanda -0.142339385967291 0.000105957763087804 NA NA NA hsa-miR-342-3p GNB5 1.4124432570595 1.07208971556131e-28 -0.984223544597764 1.38107029018304e-45 miRanda -0.289168057820866 3.15557418760236e-22 NA NA NA hsa-miR-452-3p GNB5 1.72039996672257 1.35748079442153e-22 -0.984223544597764 1.38107029018304e-45 mirMAP -0.195131022442396 9.41598127784812e-18 NA NA NA hsa-miR-590-3p GNB5 1.13702599385212 3.53435739887793e-22 -0.984223544597764 1.38107029018304e-45 miRanda -0.290635863408716 4.52232842245282e-18 NA NA NA hsa-miR-28-5p GNG12 0.461962042257226 3.32424690573327e-11 -0.585710433799246 5.64727247192656e-14 PITA;miRanda -0.213018744184183 0.000716637360164746 NA NA NA hsa-miR-455-5p GNG12 0.773674551205946 2.12957541541474e-09 -0.585710433799246 5.64727247192656e-14 miRanda -0.104628790500717 0.00192421839743675 NA NA NA hsa-miR-590-3p GNG12 1.13702599385212 3.53435739887793e-22 -0.585710433799246 5.64727247192656e-14 miRanda;mirMAP -0.166394460792321 2.45843912730583e-06 NA NA NA hsa-miR-590-5p GNG12 0.709763558412506 1.11883921359361e-11 -0.585710433799246 5.64727247192656e-14 PITA -0.136601828608981 0.000985486999487911 NA NA NA hsa-miR-29a-3p GNG2 -0.431613225927952 4.10166815070288e-08 0.823614756064967 1.80511187005109e-16 miRNATAP -0.35691220884068 7.17320168711146e-07 NA NA NA hsa-miR-29b-3p GNG2 -0.228125979913806 0.0271621721891603 0.823614756064967 1.80511187005109e-16 miRNATAP -0.206480340849552 0.000228846129353865 NA NA NA hsa-miR-29c-3p GNG2 -0.238671318446745 0.0141475322347596 0.823614756064967 1.80511187005109e-16 miRNATAP -0.267920239250733 5.99031053172155e-06 NA NA NA hsa-miR-30a-3p GNG2 -0.955360819934585 1.97009535429185e-20 0.823614756064967 1.80511187005109e-16 mirMAP -0.37288281170127 3.33907900738402e-13 NA NA NA hsa-miR-30a-5p GNG2 -0.778411951775343 2.73322451127932e-16 0.823614756064967 1.80511187005109e-16 miRNAWalker2_validate -0.412510880857411 2.55539102426618e-13 NA NA NA hsa-miR-30d-3p GNG2 -0.249777194282131 0.00235356711813496 0.823614756064967 1.80511187005109e-16 mirMAP -0.470582597511604 8.19002809998308e-12 NA NA NA hsa-miR-30e-3p GNG2 -0.205602546270795 0.00132666419729688 0.823614756064967 1.80511187005109e-16 mirMAP -0.343464152924407 0.00016836421394781 NA NA NA hsa-miR-429 GNG2 -2.16569233119434 2.66862243626443e-37 0.823614756064967 1.80511187005109e-16 miRanda;miRNATAP -0.253789883611854 1.10635594413729e-18 NA NA NA hsa-miR-500a-5p GNG2 -1.28374735824553 1.95870374809798e-20 0.823614756064967 1.80511187005109e-16 mirMAP -0.225936528577725 4.77391846047053e-09 NA NA NA hsa-miR-577 GNG2 -1.48881999472397 7.03080165111147e-10 0.823614756064967 1.80511187005109e-16 PITA;miRNATAP -0.136210305680153 2.89907477737182e-09 NA NA NA hsa-miR-126-5p GNG4 0.785607261431085 5.77058629454465e-13 -1.44375114410306 2.28630638387692e-07 mirMAP -0.597454797087056 1.5130403812957e-05 NA NA NA hsa-miR-23a-3p GNG4 0.761438723382355 4.09310879199257e-27 -1.44375114410306 2.28630638387692e-07 mirMAP -0.914505114643854 8.27962995646909e-06 NA NA NA hsa-miR-338-3p GNG4 0.906250377628867 2.76970900371139e-15 -1.44375114410306 2.28630638387692e-07 miRanda -0.546769890839939 2.68695118081473e-05 NA NA NA hsa-miR-452-5p GNG4 2.05325688842141 2.82238393643084e-40 -1.44375114410306 2.28630638387692e-07 mirMAP -0.331111037226154 0.000199421136759586 NA NA NA hsa-miR-1271-5p GNG7 0.900599702972936 3.07963385418853e-10 -1.49819687293184 1.94705916577757e-31 mirMAP -0.173568129162765 0.00107819615408948 NA NA NA hsa-miR-17-3p GNG7 0.723795600017259 5.90151677164931e-18 -1.49819687293184 1.94705916577757e-31 mirMAP -0.361965077865094 4.41700180577189e-05 NA NA NA hsa-miR-185-3p GNG7 0.993379985307475 2.62011454953707e-13 -1.49819687293184 1.94705916577757e-31 mirMAP -0.229710067712246 3.97501622169706e-05 NA NA NA hsa-miR-18a-5p GNG7 0.936704393213466 1.05064580570579e-10 -1.49819687293184 1.94705916577757e-31 mirMAP -0.348837810365023 6.96927332073749e-12 NA NA NA hsa-miR-193b-5p GNG7 0.277625648727715 0.101981573602756 -1.49819687293184 1.94705916577757e-31 mirMAP -0.179718134208955 0.000110918918737654 NA NA NA hsa-miR-1976 GNG7 0.343475600930938 0.000360243844871748 -1.49819687293184 1.94705916577757e-31 mirMAP -0.370726871325751 3.93316058485566e-06 NA NA NA hsa-miR-22-3p GNG7 0.198460552200729 0.00761005672059428 -1.49819687293184 1.94705916577757e-31 mirMAP -0.301197282065867 0.00460653426986487 NA NA NA hsa-miR-224-5p GNG7 2.84654230414912 3.0480927226395e-47 -1.49819687293184 1.94705916577757e-31 mirMAP -0.308453023695823 5.82969137794952e-22 NA NA NA hsa-miR-23a-3p GNG7 0.761438723382355 4.09310879199257e-27 -1.49819687293184 1.94705916577757e-31 mirMAP -0.698775615633595 2.84763217380429e-12 NA NA NA hsa-miR-3127-5p GNG7 0.952801473575318 5.81162987769266e-14 -1.49819687293184 1.94705916577757e-31 mirMAP -0.330875336506744 5.09478016318189e-08 NA NA NA hsa-miR-330-5p GNG7 1.44960468659754 2.12131210588035e-45 -1.49819687293184 1.94705916577757e-31 mirMAP -0.678483798096591 7.25501185995044e-29 NA NA NA hsa-miR-378a-3p GNG7 0.287244802401236 0.0501155019984562 -1.49819687293184 1.94705916577757e-31 mirMAP -0.138764304559557 0.0093327947717712 NA NA NA hsa-miR-378c GNG7 0.755048315231594 3.56147090439556e-06 -1.49819687293184 1.94705916577757e-31 mirMAP -0.227076752133234 1.50215467209031e-06 NA NA NA hsa-miR-590-3p GNG7 1.13702599385212 3.53435739887793e-22 -1.49819687293184 1.94705916577757e-31 PITA;miRanda;mirMAP -0.564634408721835 6.1436653475734e-22 NA NA NA hsa-miR-616-5p GNG7 0.913426384742148 3.78418389333709e-09 -1.49819687293184 1.94705916577757e-31 MirTarget -0.342251160982075 1.72542542503839e-12 NA NA NA hsa-miR-671-5p GNG7 0.740296481994777 8.07053661008188e-07 -1.49819687293184 1.94705916577757e-31 mirMAP -0.303845706127119 2.21754508249776e-09 NA NA NA hsa-miR-92a-3p GNG7 0.178194888895831 0.0088835082650834 -1.49819687293184 1.94705916577757e-31 miRNAWalker2_validate -0.379497275513069 0.00109890059281857 NA NA NA hsa-miR-335-5p GNGT1 -2.09515619961552 1.03765771499548e-25 2.03953706077506 5.8671355429219e-10 miRNAWalker2_validate -0.340008772213866 8.62143560659247e-05 NA NA NA hsa-miR-30c-2-3p GNGT2 -1.28402709024345 6.77577627955178e-25 0.777628423465873 2.67156169725857e-15 MirTarget -0.268089918566553 7.06377033325458e-11 NA NA NA hsa-miR-181a-5p GSK3B 1.11111114875339 3.97880443756442e-29 -0.228723498264944 0.000365732006378195 mirMAP -0.111663336693774 0.0006569391284283 NA NA NA hsa-miR-181b-5p GSK3B 1.49054296272357 3.69051660739368e-41 -0.228723498264944 0.000365732006378195 mirMAP -0.112111617296075 6.37240999540997e-05 NA NA NA hsa-miR-18a-5p GSK3B 0.936704393213466 1.05064580570579e-10 -0.228723498264944 0.000365732006378195 miRNATAP -0.129655229012053 2.96928927454631e-08 NA NA NA hsa-miR-19a-3p GSK3B 0.722913586880779 2.76301458932381e-10 -0.228723498264944 0.000365732006378195 mirMAP -0.128885925042799 1.75451278817822e-05 NA NA NA hsa-miR-19b-3p GSK3B 0.195940928879427 0.0300512922542325 -0.228723498264944 0.000365732006378195 mirMAP -0.147506705421778 0.000182148718420472 NA NA NA hsa-miR-26b-5p GSK3B -0.251437253429904 0.00270935785098697 -0.228723498264944 0.000365732006378195 miRNATAP -0.153051347819886 0.000309841684251065 NA NA NA hsa-miR-27a-3p GSK3B 0.558934437526245 1.44256383086177e-12 -0.228723498264944 0.000365732006378195 miRNATAP -0.194470247735897 7.8023921113285e-06 NA NA NA hsa-miR-590-3p GSK3B 1.13702599385212 3.53435739887793e-22 -0.228723498264944 0.000365732006378195 miRanda;miRNATAP -0.108155182029881 0.000128807781068845 NA NA NA hsa-miR-362-3p GYS1 -0.753214251798232 3.0025661608035e-07 0.832829389603171 7.29471285313563e-26 miRanda -0.14699073408119 5.28688144194905e-06 NA NA NA hsa-miR-429 GYS1 -2.16569233119434 2.66862243626443e-37 0.832829389603171 7.29471285313563e-26 miRNATAP -0.144388307946288 2.54749466149823e-09 NA NA NA hsa-miR-30e-5p HGF -0.0905907245198101 0.21196704484334 -0.738793589777388 4.41427313714235e-05 mirMAP -0.379549873001778 0.00724387151296551 NA NA NA hsa-miR-616-5p HGF 0.913426384742148 3.78418389333709e-09 -0.738793589777388 4.41427313714235e-05 mirMAP -0.206992633336022 0.00132857792892172 NA NA NA hsa-miR-651-5p HGF 0.535144061895781 2.49922577209869e-05 -0.738793589777388 4.41427313714235e-05 MirTarget -0.333113418919824 6.12549830512164e-05 NA NA NA hsa-let-7b-5p HSP90AA1 0.770868211539597 6.63408323707647e-21 -0.958352992097034 1.07709765363473e-32 miRNAWalker2_validate -0.298754776829755 8.21484864589335e-08 NA NA NA hsa-miR-16-5p HSP90AA1 0.934012514027655 4.85417898318515e-24 -0.958352992097034 1.07709765363473e-32 miRNAWalker2_validate -0.276746366972607 1.41482578068872e-08 NA NA NA hsa-miR-17-5p HSP90AA1 0.494260110870015 3.8348005261e-09 -0.958352992097034 1.07709765363473e-32 miRNAWalker2_validate -0.197913646981871 0.000581481764010899 NA NA NA hsa-miR-185-5p HSP90AA1 1.05056378692621 1.31174187880682e-22 -0.958352992097034 1.07709765363473e-32 miRNAWalker2_validate -0.112956571785311 0.00843998055710439 NA NA NA hsa-miR-186-5p HSP90AA1 0.507217561043443 9.04455748270995e-10 -0.958352992097034 1.07709765363473e-32 miRNAWalker2_validate -0.196347319895951 0.000742735828354223 NA NA NA hsa-miR-25-3p HSP90AA1 1.12016166564779 3.79069348635778e-48 -0.958352992097034 1.07709765363473e-32 miRNAWalker2_validate -0.468371801309415 4.81211034891457e-19 NA NA NA hsa-miR-374a-3p HSP90AA1 1.13863935833993 2.79089304015401e-44 -0.958352992097034 1.07709765363473e-32 MirTarget -0.448591142928581 2.82720203398032e-19 NA NA NA hsa-miR-484 HSP90AA1 0.571987778099603 9.67278224458421e-10 -0.958352992097034 1.07709765363473e-32 miRNAWalker2_validate -0.173832635048053 0.000714949773360729 NA NA NA hsa-miR-501-5p HSP90AB1 -1.1103073934745 1.81589804886553e-16 0.0832455032438588 0.160135955258652 miRNAWalker2_validate -0.100024213143585 1.13056400844272e-05 NA NA NA hsa-miR-139-5p IBSP -0.704802495091118 2.36904108453776e-06 3.65844513641542 9.76220305311432e-22 miRanda -1.04152324625837 4.45284173859163e-13 NA NA NA hsa-miR-361-5p IFNAR1 0.0514169367202078 0.382929376393199 0.10514317996324 0.0682297745500082 miRanda -0.146184449914313 0.0080804723406082 NA NA NA hsa-miR-127-3p IFNAR2 -1.21389348740811 1.68387193137287e-11 1.16163195463252 4.6258503785108e-45 miRanda -0.116929066097904 2.77439915963308e-05 NA NA NA hsa-miR-141-3p IFNAR2 -5.87110686537457 1.20877726722907e-85 1.16163195463252 4.6258503785108e-45 mirMAP -0.146849625744503 1.35924303965125e-33 NA NA NA hsa-miR-200a-3p IFNAR2 -1.43409013664263 2.00188483717828e-20 1.16163195463252 4.6258503785108e-45 mirMAP -0.12172532928145 0.000119081739660449 NA NA NA hsa-let-7i-5p IGF1R 0.911372377723717 7.11483853341932e-31 -0.350712337754094 0.000181501245112752 MirTarget;miRNATAP -0.235971113803716 8.77155505277996e-05 NA NA NA hsa-miR-140-5p IGF1R 0.504309496243674 3.09884038729031e-11 -0.350712337754094 0.000181501245112752 PITA;miRNATAP -0.181571155101918 0.00699418491290811 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-146b-5p IGF1R 1.40714170253819 2.9559871816487e-12 -0.350712337754094 0.000181501245112752 miRanda -0.152403247660519 3.66075996358974e-10 NA NA NA hsa-miR-148a-5p IGF1R 0.415500302855613 0.000691460831436767 -0.350712337754094 0.000181501245112752 mirMAP -0.170503521690951 5.04273345128948e-05 NA NA NA hsa-miR-150-5p IGF1R 1.00371863159681 1.09871676395528e-09 -0.350712337754094 0.000181501245112752 mirMAP -0.143553806575444 2.42346952261794e-06 NA NA NA hsa-miR-152-3p IGF1R 0.187079360533734 0.052276214844753 -0.350712337754094 0.000181501245112752 miRNAWalker2_validate;miRTarBase -0.190544615783346 0.000432891552015195 NA NA NA hsa-miR-155-5p IGF1R 3.26274490570809 5.06841441826518e-51 -0.350712337754094 0.000181501245112752 mirMAP -0.136590052634235 4.91008523423482e-12 NA NA NA hsa-miR-15a-5p IGF1R 1.42663930007845 1.36006952074963e-57 -0.350712337754094 0.000181501245112752 miRNATAP -0.229960567738301 2.06108623158748e-06 NA NA NA hsa-miR-15b-3p IGF1R 1.49422666971434 5.44139893275088e-29 -0.350712337754094 0.000181501245112752 mirMAP -0.134683049212029 0.000147723404766299 NA NA NA hsa-miR-15b-5p IGF1R 0.773001494057531 1.71784656078957e-16 -0.350712337754094 0.000181501245112752 miRNATAP -0.304632210575091 5.12529969919797e-09 NA NA NA hsa-miR-16-1-3p IGF1R 1.51429140700091 3.17219833254498e-37 -0.350712337754094 0.000181501245112752 mirMAP -0.123058260397 0.00189781201814508 NA NA NA hsa-miR-16-5p IGF1R 0.934012514027655 4.85417898318515e-24 -0.350712337754094 0.000181501245112752 miRNATAP -0.222754861619978 2.02733002979059e-05 23507142 Furthermore we confirmed that IGF1R is a direct target of miR-16; In clinical specimens IGF1R levels inversely correlate with miR-16 expression; Our results provide significant clues regarding the role of miR-16 as a tumor suppressor by targeting IGF1R in OS sarcoma hsa-miR-181b-5p IGF1R 1.49054296272357 3.69051660739368e-41 -0.350712337754094 0.000181501245112752 miRNAWalker2_validate -0.16087164704991 9.10123692332483e-05 NA NA NA hsa-miR-185-5p IGF1R 1.05056378692621 1.31174187880682e-22 -0.350712337754094 0.000181501245112752 MirTarget -0.186053432064591 3.69788233879511e-05 NA NA NA hsa-miR-186-5p IGF1R 0.507217561043443 9.04455748270995e-10 -0.350712337754094 0.000181501245112752 mirMAP -0.331419313505495 5.07936007018379e-08 NA NA NA hsa-miR-193a-5p IGF1R 1.29777740059595 2.16815694068336e-39 -0.350712337754094 0.000181501245112752 mirMAP -0.282185055621775 6.5125643029761e-10 NA NA NA hsa-miR-19a-3p IGF1R 0.722913586880779 2.76301458932381e-10 -0.350712337754094 0.000181501245112752 mirMAP -0.147886658493526 0.000827009672119645 NA NA NA hsa-miR-22-5p IGF1R -0.197038086012602 0.106234828461117 -0.350712337754094 0.000181501245112752 miRNATAP -0.218185482688399 2.31606589217884e-07 NA NA NA hsa-miR-223-3p IGF1R 1.23291409735619 1.07767240442694e-17 -0.350712337754094 0.000181501245112752 miRNAWalker2_validate;miRTarBase;MirTarget -0.207002717101274 6.7497817419045e-10 NA NA NA hsa-miR-224-5p IGF1R 2.84654230414912 3.0480927226395e-47 -0.350712337754094 0.000181501245112752 mirMAP -0.12497449009427 2.14169011755518e-08 NA NA NA hsa-miR-27a-3p IGF1R 0.558934437526245 1.44256383086177e-12 -0.350712337754094 0.000181501245112752 mirMAP -0.289086082917443 5.70429020582017e-06 NA NA NA hsa-miR-28-3p IGF1R 1.01277915413238 1.8655970171461e-43 -0.350712337754094 0.000181501245112752 miRNATAP -0.283676409136567 4.77334416869934e-06 NA NA NA hsa-miR-29b-3p IGF1R -0.228125979913806 0.0271621721891603 -0.350712337754094 0.000181501245112752 mirMAP -0.180564508317091 0.000341128991851936 NA NA NA hsa-miR-320b IGF1R 0.300497419754843 0.0245219177384172 -0.350712337754094 0.000181501245112752 PITA;mirMAP;miRNATAP -0.147694319321643 0.000138439977633767 NA NA NA hsa-miR-330-3p IGF1R 0.912906550436308 3.35037014057665e-13 -0.350712337754094 0.000181501245112752 MirTarget;PITA;miRNATAP -0.134477746862817 0.000990824178827728 NA NA NA hsa-miR-331-5p IGF1R 0.661186030542026 1.83628790002785e-08 -0.350712337754094 0.000181501245112752 PITA -0.195351804223524 1.40133581842936e-05 NA NA NA hsa-miR-339-5p IGF1R 0.322848334531193 0.0117281778821612 -0.350712337754094 0.000181501245112752 miRanda -0.163351873718725 5.15049729928241e-05 NA NA NA hsa-miR-342-3p IGF1R 1.4124432570595 1.07208971556131e-28 -0.350712337754094 0.000181501245112752 mirMAP -0.194272553620367 1.46833451467849e-07 NA NA NA hsa-miR-342-5p IGF1R 1.37011183051517 4.99462376051624e-28 -0.350712337754094 0.000181501245112752 mirMAP -0.20160351781794 8.83447249312956e-08 NA NA NA hsa-miR-34a-5p IGF1R 1.07544567720768 1.81510842038009e-20 -0.350712337754094 0.000181501245112752 miRNAWalker2_validate -0.199114338235112 1.92827507575165e-06 NA NA NA hsa-miR-3613-5p IGF1R 1.6648190889407 3.78720979041391e-41 -0.350712337754094 0.000181501245112752 mirMAP;miRNATAP -0.216252562136664 2.97012797504412e-09 NA NA NA hsa-miR-365a-3p IGF1R 0.80809616164259 2.36039522526e-12 -0.350712337754094 0.000181501245112752 MirTarget -0.257585442885011 1.78868807843146e-09 NA NA NA hsa-miR-3677-3p IGF1R 0.795647411414935 8.55447772820001e-08 -0.350712337754094 0.000181501245112752 MirTarget -0.148125144581854 1.72647727870061e-05 NA NA NA hsa-miR-452-5p IGF1R 2.05325688842141 2.82238393643084e-40 -0.350712337754094 0.000181501245112752 mirMAP -0.152551163662331 1.80294964421603e-07 NA NA NA hsa-miR-484 IGF1R 0.571987778099603 9.67278224458421e-10 -0.350712337754094 0.000181501245112752 miRNAWalker2_validate -0.287005519658643 9.24245685466692e-08 NA NA NA hsa-miR-625-5p IGF1R 0.153090549230629 0.330314026509869 -0.350712337754094 0.000181501245112752 MirTarget -0.174794954597001 8.31464126079677e-07 NA NA NA hsa-miR-671-5p IGF1R 0.740296481994777 8.07053661008188e-07 -0.350712337754094 0.000181501245112752 mirMAP -0.192811849893229 1.28982078484569e-08 NA NA NA hsa-miR-1270 IGF2 1.71697026896618 1.75919401373445e-16 -2.34687860267691 1.42284788106786e-12 mirMAP -0.73515689729303 3.91146297613841e-19 NA NA NA hsa-miR-130b-3p IGF2 1.12788913578446 2.939369462276e-16 -2.34687860267691 1.42284788106786e-12 mirMAP -0.383536395412308 0.00349967963548454 NA NA NA hsa-miR-148a-3p IGF2 0.343233211643815 0.00402279073598165 -2.34687860267691 1.42284788106786e-12 mirMAP -0.654138259141622 3.32865042161338e-05 NA NA NA hsa-miR-148b-3p IGF2 0.346011252093377 4.27203463315056e-06 -2.34687860267691 1.42284788106786e-12 mirMAP -1.71895491015101 1.85621380140659e-12 NA NA NA hsa-miR-150-5p IGF2 1.00371863159681 1.09871676395528e-09 -2.34687860267691 1.42284788106786e-12 miRNAWalker2_validate -0.504624603673111 5.55334474383065e-06 NA NA NA hsa-miR-192-3p IGF2 0.156650099616707 0.483496040900362 -2.34687860267691 1.42284788106786e-12 miRNATAP -0.496197183736798 2.88450959711526e-09 NA NA NA hsa-miR-192-5p IGF2 0.442478872410106 0.0669238175123954 -2.34687860267691 1.42284788106786e-12 mirMAP -0.705443978199752 8.38434404741778e-22 NA NA NA hsa-miR-193a-5p IGF2 1.29777740059595 2.16815694068336e-39 -2.34687860267691 1.42284788106786e-12 TargetScan -0.725320261377095 1.76455770060032e-05 NA NA NA hsa-miR-193b-5p IGF2 0.277625648727715 0.101981573602756 -2.34687860267691 1.42284788106786e-12 mirMAP -0.406407934916035 0.000319819516609851 NA NA NA hsa-miR-19a-3p IGF2 0.722913586880779 2.76301458932381e-10 -2.34687860267691 1.42284788106786e-12 mirMAP -0.483354371261257 0.00275245752352663 NA NA NA hsa-miR-210-3p IGF2 3.47797426172621 4.63893951975373e-58 -2.34687860267691 1.42284788106786e-12 MirTarget -0.399171749413733 2.48383490756897e-08 NA NA NA hsa-miR-2355-5p IGF2 1.57515081110162 3.54962327490702e-48 -2.34687860267691 1.42284788106786e-12 MirTarget -0.759977156661094 3.56542845876582e-07 NA NA NA hsa-miR-342-5p IGF2 1.37011183051517 4.99462376051624e-28 -2.34687860267691 1.42284788106786e-12 MirTarget;mirMAP;miRNATAP -0.778822292861011 1.28924754059121e-08 NA NA NA hsa-miR-34a-5p IGF2 1.07544567720768 1.81510842038009e-20 -2.34687860267691 1.42284788106786e-12 mirMAP -0.58108770683083 0.000151312903300126 NA NA NA hsa-miR-361-3p IGF2 1.08992546227594 1.13197240706704e-36 -2.34687860267691 1.42284788106786e-12 mirMAP -1.24161356747156 1.14100755076694e-10 NA NA NA hsa-miR-365a-3p IGF2 0.80809616164259 2.36039522526e-12 -2.34687860267691 1.42284788106786e-12 MirTarget -0.502435693396011 0.00159623003066334 NA NA NA hsa-miR-454-3p IGF2 0.68285296887698 1.17407812677787e-08 -2.34687860267691 1.42284788106786e-12 mirMAP -0.811242152746126 1.13111009951846e-07 NA NA NA hsa-miR-455-5p IGF2 0.773674551205946 2.12957541541474e-09 -2.34687860267691 1.42284788106786e-12 mirMAP -0.633432384566236 8.30880921791159e-06 NA NA NA hsa-miR-484 IGF2 0.571987778099603 9.67278224458421e-10 -2.34687860267691 1.42284788106786e-12 miRNATAP -0.808384230578006 4.28299864386457e-05 NA NA NA hsa-miR-93-5p IGF2 1.37365940377595 2.37567548683245e-46 -2.34687860267691 1.42284788106786e-12 miRNAWalker2_validate -1.04972427218725 3.52183702203594e-10 NA NA NA hsa-miR-125a-5p IKBKG -0.561874059994802 7.3931856356891e-13 0.49642799282577 6.30392568162462e-12 miRanda -0.278136800860417 3.13020186123498e-08 NA NA NA hsa-miR-3065-3p IL2RA -1.64500070417457 9.57561660036697e-16 2.10873252704572 9.99428856889031e-18 MirTarget -0.344433151078364 1.55794209180431e-07 NA NA NA hsa-miR-500a-3p IL2RA -1.41379327701944 2.73403824528455e-37 2.10873252704572 9.99428856889031e-18 MirTarget -0.689805364156805 9.4316685114978e-10 NA NA NA hsa-miR-125a-5p IL2RB -0.561874059994802 7.3931856356891e-13 3.3475085815016 3.78227657279626e-65 miRanda -1.32471955838635 4.85701489011067e-17 NA NA NA hsa-miR-139-5p IL2RB -0.704802495091118 2.36904108453776e-06 3.3475085815016 3.78227657279626e-65 miRanda -0.437746244840167 4.32946589039136e-07 NA NA NA hsa-miR-30b-3p IL2RB -1.64703050862226 1.89878531036464e-31 3.3475085815016 3.78227657279626e-65 mirMAP -0.8721459102493 2.46203627751483e-28 NA NA NA hsa-miR-362-3p IL3RA -0.753214251798232 3.0025661608035e-07 1.61131969334758 1.96984916616799e-32 miRanda -0.289330502310158 3.01527391899967e-07 NA NA NA hsa-miR-125a-3p IL4R -0.372794471295036 0.000941729459601642 1.49677954940201 5.82824628338837e-49 miRanda -0.159706515114085 0.00599147791408276 NA NA NA hsa-miR-199a-5p IL4R -1.64658415208633 1.01615659358973e-23 1.49677954940201 5.82824628338837e-49 miRNATAP -0.165451960039341 6.80976697584275e-06 NA NA NA hsa-miR-429 IL4R -2.16569233119434 2.66862243626443e-37 1.49677954940201 5.82824628338837e-49 miRNATAP -0.279597082387011 1.10779269370854e-17 NA NA NA hsa-miR-107 IL6 0.140046250553248 0.0943611632552367 -0.432551704985806 0.174200627733491 miRanda -0.626802809840839 0.00308751628926532 NA NA NA hsa-miR-139-5p IL6 -0.704802495091118 2.36904108453776e-06 -0.432551704985806 0.174200627733491 miRanda -0.314265848732322 0.00673546049087722 NA NA NA hsa-miR-338-5p IL6 0.628429807914222 1.27575140717947e-06 -0.432551704985806 0.174200627733491 MirTarget;PITA -0.580992506147854 1.66390019671047e-05 NA NA NA hsa-let-7e-5p IL6R -0.727009689927955 1.30690859412163e-11 0.972862618334167 1.56964143104202e-11 miRNATAP -0.252752871810542 0.000660501453991924 NA NA NA hsa-let-7g-5p IL6R -0.739744008507763 1.07979566264383e-14 0.972862618334167 1.56964143104202e-11 miRNATAP -0.239374174285825 0.00384605528970956 NA NA NA hsa-miR-125a-5p IL6R -0.561874059994802 7.3931856356891e-13 0.972862618334167 1.56964143104202e-11 MirTarget;miRanda -0.322679083593268 0.00159012681584773 NA NA NA hsa-miR-125b-5p IL6R -0.825456421494266 2.13029877878434e-15 0.972862618334167 1.56964143104202e-11 miRTarBase;MirTarget -0.31503876661173 2.89797058763512e-05 22942733 The ectopic expression of miR-125b reduced the cellular proliferation and cell cycle progression of HCC cells by targeting Mcl-1 and IL6R progression liver cancer hsa-miR-130a-3p IL6R -0.667386596699886 1.34029167767774e-10 0.972862618334167 1.56964143104202e-11 mirMAP -0.355333608036724 3.34709945184669e-06 NA NA NA hsa-miR-135b-5p IL6R -1.12731059106515 6.06922867778145e-08 0.972862618334167 1.56964143104202e-11 mirMAP -0.192801757765878 5.32192209374102e-07 NA NA NA hsa-miR-141-3p IL6R -5.87110686537457 1.20877726722907e-85 0.972862618334167 1.56964143104202e-11 MirTarget -0.168219437994158 7.67162387417505e-17 NA NA NA hsa-miR-182-5p IL6R -0.608710746044567 0.0025264935278104 0.972862618334167 1.56964143104202e-11 mirMAP -0.209060391288049 1.66329321365e-07 NA NA NA hsa-miR-193b-3p IL6R -0.273325765316079 0.104328826585392 0.972862618334167 1.56964143104202e-11 mirMAP -0.143100304242552 0.00338313506548892 NA NA NA hsa-miR-29a-5p IL6R -0.519003718107105 1.03351148282116e-06 0.972862618334167 1.56964143104202e-11 mirMAP -0.309163432959387 4.77671025101178e-05 NA NA NA hsa-miR-30b-5p IL6R -1.18330589477119 6.8341618466966e-27 0.972862618334167 1.56964143104202e-11 mirMAP -0.180519271686128 0.00882857209665063 NA NA NA hsa-miR-335-5p IL6R -2.09515619961552 1.03765771499548e-25 0.972862618334167 1.56964143104202e-11 mirMAP -0.192465311053153 3.59665460891334e-07 NA NA NA hsa-miR-33a-5p IL6R -1.59840463890997 1.13487952314403e-18 0.972862618334167 1.56964143104202e-11 mirMAP -0.131237784810567 0.00229977004142412 NA NA NA hsa-miR-125a-3p IL7 -0.372794471295036 0.000941729459601642 1.13806384776766 2.49308081070627e-22 miRanda -0.280128044841504 3.94356967379565e-06 NA NA NA hsa-miR-335-3p IL7 -1.36498175550207 6.84287752180534e-13 1.13806384776766 2.49308081070627e-22 mirMAP -0.103522186738094 0.00316757210475103 NA NA NA hsa-miR-335-5p IL7 -2.09515619961552 1.03765771499548e-25 1.13806384776766 2.49308081070627e-22 miRNAWalker2_validate -0.164678918721996 2.202357769123e-07 NA NA NA hsa-miR-429 IL7 -2.16569233119434 2.66862243626443e-37 1.13806384776766 2.49308081070627e-22 miRanda -0.266134283710059 2.28778200379979e-14 NA NA NA hsa-miR-125a-5p IL7R -0.561874059994802 7.3931856356891e-13 1.60171759676547 2.18199799378877e-10 miRanda -0.659685143855203 0.000203244531868886 NA NA NA hsa-miR-501-5p IL7R -1.1103073934745 1.81589804886553e-16 1.60171759676547 2.18199799378877e-10 mirMAP -0.289151794747211 0.00432536351288238 NA NA NA hsa-let-7g-5p INSR -0.739744008507763 1.07979566264383e-14 1.22098476669768 3.16404602120675e-24 miRNATAP -0.395547105658983 2.23686684327675e-08 NA NA NA hsa-miR-127-5p INSR -1.33574359249785 5.73079880594981e-13 1.22098476669768 3.16404602120675e-24 PITA -0.127873340011271 0.00054969179221113 NA NA NA hsa-miR-141-3p INSR -5.87110686537457 1.20877726722907e-85 1.22098476669768 3.16404602120675e-24 mirMAP -0.193501789971366 6.25874754232476e-31 27186273 microRNA 141 inhibits thyroid cancer cell growth and metastasis by targeting insulin receptor substrate 2 metastasis thyroid cancer hsa-miR-200a-3p INSR -1.43409013664263 2.00188483717828e-20 1.22098476669768 3.16404602120675e-24 mirMAP -0.220629068778301 2.49414920313771e-07 NA NA NA hsa-miR-335-3p INSR -1.36498175550207 6.84287752180534e-13 1.22098476669768 3.16404602120675e-24 mirMAP -0.269288069300444 1.16034201980538e-14 23966614 miR 335 inhibits small cell lung cancer bone metastases via IGF IR and RANKL pathways metastasis lung squamous cell cancer hsa-miR-429 INSR -2.16569233119434 2.66862243626443e-37 1.22098476669768 3.16404602120675e-24 miRNATAP -0.233302577772816 1.65426561724317e-10 NA NA NA hsa-miR-495-3p INSR -0.742293735164333 7.11373308013543e-05 1.22098476669768 3.16404602120675e-24 mirMAP -0.157976472369521 4.66370468956541e-05 NA NA NA hsa-miR-501-5p INSR -1.1103073934745 1.81589804886553e-16 1.22098476669768 3.16404602120675e-24 miRNATAP -0.321346382831813 6.65387363749468e-11 NA NA NA hsa-miR-539-5p INSR -1.44841597031461 8.25650852878567e-11 1.22098476669768 3.16404602120675e-24 mirMAP -0.142403631765939 6.87039219743717e-06 NA NA NA hsa-miR-128-3p IRS1 0.475045893035043 2.6255647468e-06 -1.33765917687748 2.26716594890364e-19 MirTarget -0.393993350797093 2.99015067506251e-06 26352220 In addition insulin receptor substrate 1 IRS1 a key mediator in oncogenic insulin-like growth factor IGF signaling was confirmed as a direct target of miR-128 by a luciferase reporter assay; Western blot analysis indicated that the overexpression of miR-128 significantly downregulated IRS1 expression and its downstream Akt signaling in CRC cells; Moreover miR-128 was negatively associated with IRS1 in CRC tissues compared to adjacent non-tumor tissues; Taken together these data suggested that miR-128 serves as a tumor suppressor and blocks CRC growth and metastasis by targeting IRS1 metastasis colorectal cancer hsa-miR-142-5p IRS1 1.88417391525707 1.2096808039882e-27 -1.33765917687748 2.26716594890364e-19 MirTarget;PITA -0.382980018761218 2.2274541214324e-18 NA NA NA hsa-miR-144-3p IRS1 1.4617706700291 9.18139413836375e-11 -1.33765917687748 2.26716594890364e-19 MirTarget;miRNATAP -0.122286100812769 0.00105931976224342 NA NA NA hsa-miR-16-1-3p IRS1 1.51429140700091 3.17219833254498e-37 -1.33765917687748 2.26716594890364e-19 MirTarget -0.512963301381382 6.36286018038595e-16 NA NA NA hsa-miR-17-3p IRS1 0.723795600017259 5.90151677164931e-18 -1.33765917687748 2.26716594890364e-19 MirTarget -0.419735170491093 2.01058465495148e-05 NA NA NA hsa-miR-2355-3p IRS1 1.32757890426926 1.88016636795886e-18 -1.33765917687748 2.26716594890364e-19 MirTarget -0.273078662239628 7.16428473599373e-07 NA NA NA hsa-miR-27a-3p IRS1 0.558934437526245 1.44256383086177e-12 -1.33765917687748 2.26716594890364e-19 MirTarget;miRNATAP -0.474391620144697 8.45388398021456e-06 NA NA NA hsa-miR-338-3p IRS1 0.906250377628867 2.76970900371139e-15 -1.33765917687748 2.26716594890364e-19 miRanda -0.277781961044353 0.000123476769537518 NA NA NA hsa-miR-421 IRS1 0.313155739887734 0.020433534776003 -1.33765917687748 2.26716594890364e-19 PITA;miRanda;miRNATAP -0.266015980095408 5.64142026426368e-05 NA NA NA hsa-miR-590-3p IRS1 1.13702599385212 3.53435739887793e-22 -1.33765917687748 2.26716594890364e-19 PITA;miRanda;miRNATAP -0.370096140346283 6.27135450829204e-08 NA NA NA hsa-miR-616-5p IRS1 0.913426384742148 3.78418389333709e-09 -1.33765917687748 2.26716594890364e-19 MirTarget -0.150456808777232 0.00693494612765847 NA NA NA hsa-miR-200a-5p ITGA1 -1.36295040293874 1.31587720312419e-22 0.666372596233094 8.23867369110692e-08 mirMAP -0.216160919269695 3.14252444599031e-06 NA NA NA hsa-miR-200b-3p ITGA1 -1.70383252137161 2.38979336321755e-30 0.666372596233094 8.23867369110692e-08 MirTarget -0.271165659076172 7.31601887835733e-11 NA NA NA hsa-miR-200b-5p ITGA1 -1.46985752435972 3.43232443788022e-27 0.666372596233094 8.23867369110692e-08 mirMAP -0.347654972107119 3.27696715837342e-14 NA NA NA hsa-miR-200c-3p ITGA1 -5.40303134829523 2.74173143360645e-94 0.666372596233094 8.23867369110692e-08 MirTarget -0.127656447466879 4.95564545042498e-11 NA NA NA hsa-miR-335-5p ITGA1 -2.09515619961552 1.03765771499548e-25 0.666372596233094 8.23867369110692e-08 miRNAWalker2_validate -0.125445694454195 0.000109065624317462 NA NA NA hsa-miR-362-3p ITGA1 -0.753214251798232 3.0025661608035e-07 0.666372596233094 8.23867369110692e-08 miRanda -0.286695349118566 1.22518413610378e-09 NA NA NA hsa-miR-429 ITGA1 -2.16569233119434 2.66862243626443e-37 0.666372596233094 8.23867369110692e-08 MirTarget;miRanda -0.231896621829054 7.95714212413463e-11 NA NA NA hsa-let-7a-2-3p ITGA10 -0.705630646340993 0.000144853804998033 0.726914264927171 8.60399006747605e-05 MirTarget -0.149026476557685 0.007093710769077 NA NA NA hsa-let-7g-3p ITGA10 -0.265047454512772 0.0213585204640049 0.726914264927171 8.60399006747605e-05 MirTarget;miRNATAP -0.501571365769031 1.22712958908513e-08 NA NA NA hsa-miR-107 ITGA10 0.140046250553248 0.0943611632552367 0.726914264927171 8.60399006747605e-05 miRanda -0.418163522136431 0.00075809860179381 NA NA NA hsa-miR-22-3p ITGA10 0.198460552200729 0.00761005672059428 0.726914264927171 8.60399006747605e-05 MirTarget -0.964223707922462 1.22751582128264e-12 NA NA NA hsa-miR-324-5p ITGA10 -0.487750893426456 3.74472736457965e-05 0.726914264927171 8.60399006747605e-05 miRanda;miRNATAP -0.493046645427276 6.16061022539471e-09 NA NA NA hsa-miR-335-5p ITGA10 -2.09515619961552 1.03765771499548e-25 0.726914264927171 8.60399006747605e-05 miRNAWalker2_validate -0.240604655204143 3.9541252033775e-07 NA NA NA hsa-miR-429 ITGA10 -2.16569233119434 2.66862243626443e-37 0.726914264927171 8.60399006747605e-05 miRanda;miRNATAP -0.267553981181386 5.22336160672069e-07 NA NA NA hsa-miR-616-5p ITGA10 0.913426384742148 3.78418389333709e-09 0.726914264927171 8.60399006747605e-05 mirMAP;miRNATAP -0.281079091916412 1.79269327824491e-05 NA NA NA hsa-miR-940 ITGA10 -0.160421460715008 0.279016637176929 0.726914264927171 8.60399006747605e-05 MirTarget;miRNATAP -0.244050931998397 0.000793918196659878 NA NA NA hsa-miR-103a-3p ITGA2 0.779373475434461 7.37867196796994e-20 -1.08388449508643 1.56728724217302e-16 miRNAWalker2_validate;MirTarget;miRNATAP -0.419895180265999 4.91303588784847e-07 NA NA NA hsa-miR-107 ITGA2 0.140046250553248 0.0943611632552367 -1.08388449508643 1.56728724217302e-16 MirTarget;miRanda;miRNATAP -0.39500807003267 1.45081117707125e-05 NA NA NA hsa-miR-130b-3p ITGA2 1.12788913578446 2.939369462276e-16 -1.08388449508643 1.56728724217302e-16 mirMAP -0.301078183289923 5.74875888533156e-09 NA NA NA hsa-miR-142-3p ITGA2 1.88928758773299 2.72985643829893e-22 -1.08388449508643 1.56728724217302e-16 miRanda -0.181925006393419 4.35157712604764e-07 NA NA NA hsa-miR-15a-5p ITGA2 1.42663930007845 1.36006952074963e-57 -1.08388449508643 1.56728724217302e-16 MirTarget;miRNATAP -0.550597246380852 1.03193099020898e-15 NA NA NA hsa-miR-15b-5p ITGA2 0.773001494057531 1.71784656078957e-16 -1.08388449508643 1.56728724217302e-16 MirTarget;miRNATAP -0.401580517439157 1.59762423415028e-07 NA NA NA hsa-miR-16-5p ITGA2 0.934012514027655 4.85417898318515e-24 -1.08388449508643 1.56728724217302e-16 miRNAWalker2_validate;MirTarget;miRNATAP -0.45864815574881 1.14236037377433e-09 NA NA NA hsa-miR-181a-5p ITGA2 1.11111114875339 3.97880443756442e-29 -1.08388449508643 1.56728724217302e-16 MirTarget -0.240540213003525 0.000614026393391858 NA NA NA hsa-miR-181b-5p ITGA2 1.49054296272357 3.69051660739368e-41 -1.08388449508643 1.56728724217302e-16 MirTarget -0.260977698431527 1.3381994160642e-05 NA NA NA hsa-miR-185-5p ITGA2 1.05056378692621 1.31174187880682e-22 -1.08388449508643 1.56728724217302e-16 miRNATAP -0.440454395431351 8.40284340534913e-12 NA NA NA hsa-miR-186-5p ITGA2 0.507217561043443 9.04455748270995e-10 -1.08388449508643 1.56728724217302e-16 mirMAP -0.315820034560473 0.000458722104915937 NA NA NA hsa-miR-18a-5p ITGA2 0.936704393213466 1.05064580570579e-10 -1.08388449508643 1.56728724217302e-16 MirTarget -0.269671283120125 7.74562619345101e-08 NA NA NA hsa-miR-19a-3p ITGA2 0.722913586880779 2.76301458932381e-10 -1.08388449508643 1.56728724217302e-16 MirTarget -0.188951928102935 0.00355080009303547 NA NA NA hsa-miR-330-5p ITGA2 1.44960468659754 2.12131210588035e-45 -1.08388449508643 1.56728724217302e-16 PITA -0.273200724643208 2.02579830641045e-05 NA NA NA hsa-miR-340-5p ITGA2 1.14479851941741 2.91936881701444e-15 -1.08388449508643 1.56728724217302e-16 mirMAP -0.182858378643398 0.000255888563223987 NA NA NA hsa-miR-374a-5p ITGA2 0.543061152108237 2.19403097299769e-14 -1.08388449508643 1.56728724217302e-16 MirTarget -0.420504545654072 4.84584405234286e-05 NA NA NA hsa-miR-374b-5p ITGA2 0.0804104684417872 0.365593963035077 -1.08388449508643 1.56728724217302e-16 MirTarget -0.371842793300295 1.46801328770967e-05 NA NA NA hsa-miR-590-3p ITGA2 1.13702599385212 3.53435739887793e-22 -1.08388449508643 1.56728724217302e-16 MirTarget;miRanda;mirMAP -0.354910578826915 2.56472998666883e-09 NA NA NA hsa-miR-590-5p ITGA2 0.709763558412506 1.11883921359361e-11 -1.08388449508643 1.56728724217302e-16 miRanda -0.382977146193393 3.76588814581367e-08 NA NA NA hsa-miR-324-5p ITGA2B -0.487750893426456 3.74472736457965e-05 0.241072870335405 0.299000029204101 miRanda -0.374180405131952 0.000469303929768756 NA NA NA hsa-miR-139-5p ITGA3 -0.704802495091118 2.36904108453776e-06 0.536815367938215 1.58238415069395e-05 PITA;miRanda -0.272952431176537 1.11529961139835e-09 NA NA NA hsa-miR-199a-5p ITGA4 -1.64658415208633 1.01615659358973e-23 1.81804937034926 2.10290276216623e-35 miRanda -0.161321830038808 0.00159492880700006 NA NA NA hsa-miR-199b-5p ITGA4 -2.39483476763681 1.04659509514884e-17 1.81804937034926 2.10290276216623e-35 miRanda -0.127027558361016 4.42589341965933e-05 NA NA NA hsa-miR-30c-5p ITGA4 -1.08783070774238 2.02505402525786e-24 1.81804937034926 2.10290276216623e-35 miRNAWalker2_validate -0.552982244955524 3.98862457291834e-13 NA NA NA hsa-miR-362-3p ITGA4 -0.753214251798232 3.0025661608035e-07 1.81804937034926 2.10290276216623e-35 miRanda -0.350631758867594 9.782406185973e-09 NA NA NA hsa-miR-183-5p ITGA5 -1.21596931064487 1.31473205758898e-08 2.04116263996683 7.34474138145585e-47 miRNAWalker2_validate -0.168509641988799 4.28263649045998e-05 NA NA NA hsa-miR-27b-3p ITGA5 -0.699527231242518 1.07356023759234e-15 2.04116263996683 7.34474138145585e-47 miRNATAP -0.665011188256571 8.42719111597212e-12 NA NA NA hsa-miR-3065-3p ITGA5 -1.64500070417457 9.57561660036697e-16 2.04116263996683 7.34474138145585e-47 miRNATAP -0.336097070488892 8.38394013805882e-17 NA NA NA hsa-miR-30a-5p ITGA5 -0.778411951775343 2.73322451127932e-16 2.04116263996683 7.34474138145585e-47 miRNATAP -0.963193438692052 8.11656677667882e-31 NA NA NA hsa-miR-30c-5p ITGA5 -1.08783070774238 2.02505402525786e-24 2.04116263996683 7.34474138145585e-47 miRNATAP -0.80466770180918 2.23719209001784e-28 NA NA NA hsa-miR-30d-5p ITGA5 -0.202727675788184 0.00659067084745794 2.04116263996683 7.34474138145585e-47 miRNATAP -0.832879085803553 2.90046596941365e-12 NA NA NA hsa-miR-429 ITGA5 -2.16569233119434 2.66862243626443e-37 2.04116263996683 7.34474138145585e-47 miRNATAP -0.500173657300576 8.56440818684276e-31 NA NA NA hsa-miR-186-5p ITGA6 0.507217561043443 9.04455748270995e-10 0.167105105615827 0.12461302046863 mirMAP -0.201218645202198 0.00473534623896577 NA NA NA hsa-miR-335-3p ITGA6 -1.36498175550207 6.84287752180534e-13 0.167105105615827 0.12461302046863 mirMAP -0.147097851280781 9.90853009360868e-07 NA NA NA hsa-miR-34a-5p ITGA6 1.07544567720768 1.81510842038009e-20 0.167105105615827 0.12461302046863 miRNAWalker2_validate -0.193612551449907 6.37810719751089e-05 NA NA NA hsa-miR-590-3p ITGA6 1.13702599385212 3.53435739887793e-22 0.167105105615827 0.12461302046863 PITA;miRanda;mirMAP -0.126453327854232 0.00838117948797664 NA NA NA hsa-miR-362-3p ITGA7 -0.753214251798232 3.0025661608035e-07 0.900337418794853 1.11981852012182e-10 miRanda -0.19985128421064 0.000244748988921607 NA NA NA hsa-miR-130b-3p ITGA8 1.12788913578446 2.939369462276e-16 -1.18440342923207 3.23543026206956e-06 mirMAP -0.562989405548411 6.00716979867949e-09 NA NA NA hsa-miR-16-1-3p ITGA8 1.51429140700091 3.17219833254498e-37 -1.18440342923207 3.23543026206956e-06 mirMAP -0.399903873425147 0.000217091537413453 NA NA NA hsa-miR-21-5p ITGA8 2.51462371613332 3.30620591950316e-66 -1.18440342923207 3.23543026206956e-06 mirMAP -0.443019239410909 1.20331359087673e-08 NA NA NA hsa-miR-454-3p ITGA8 0.68285296887698 1.17407812677787e-08 -1.18440342923207 3.23543026206956e-06 mirMAP -0.309806598511538 0.00797932716617233 NA NA NA hsa-miR-590-5p ITGA8 0.709763558412506 1.11883921359361e-11 -1.18440342923207 3.23543026206956e-06 mirMAP -0.588102916607331 7.55280066425446e-06 NA NA NA hsa-miR-223-3p ITGA9 1.23291409735619 1.07767240442694e-17 -0.305884010900922 0.0603343289576787 mirMAP -0.185871049032298 0.00168936409896778 24333181 Our aim was to investigate miR-223 regulation in HCC miR-223 and integrin αV dysregulation were verified in 57 HCC specimens; Enhanced miR-223 expression had a negative effect on integrin αV-mediated cell migration; Further analysis demonstrated that integrin αV is negatively regulated by miR-223 cell migration liver cancer hsa-miR-421 ITGA9 0.313155739887734 0.020433534776003 -0.305884010900922 0.0603343289576787 mirMAP -0.230685773278449 0.000763194530057629 NA NA NA hsa-miR-501-5p ITGA9 -1.1103073934745 1.81589804886553e-16 -0.305884010900922 0.0603343289576787 MirTarget -0.184674273556277 0.00366342388986055 NA NA NA hsa-miR-589-3p ITGA9 -0.0184909376114044 0.903149951095234 -0.305884010900922 0.0603343289576787 mirMAP -0.158232680174833 0.00892276087760671 NA NA NA hsa-miR-590-3p ITGA9 1.13702599385212 3.53435739887793e-22 -0.305884010900922 0.0603343289576787 miRanda -0.330215531987037 3.43672124412268e-06 NA NA NA hsa-miR-590-5p ITGA9 0.709763558412506 1.11883921359361e-11 -0.305884010900922 0.0603343289576787 miRanda -0.312466526683047 0.000174562117230751 NA NA NA hsa-miR-616-5p ITGA9 0.913426384742148 3.78418389333709e-09 -0.305884010900922 0.0603343289576787 mirMAP -0.205372643388639 0.000343162663980841 NA NA NA hsa-let-7a-3p ITGAV 0.0677487960013088 0.460458477653989 -0.361899844330413 0.00011347300913332 MirTarget -0.188911001850044 0.000960608483582614 NA NA NA hsa-miR-25-3p ITGAV 1.12016166564779 3.79069348635778e-48 -0.361899844330413 0.00011347300913332 MirTarget;miRNATAP -0.157237225581948 0.00757909498068144 NA NA NA hsa-miR-32-5p ITGAV 0.407826130035097 7.26884631998646e-06 -0.361899844330413 0.00011347300913332 miRNAWalker2_validate;MirTarget;miRNATAP -0.167851835458867 0.00323387736288527 NA NA NA hsa-miR-361-5p ITGAV 0.0514169367202078 0.382929376393199 -0.361899844330413 0.00011347300913332 MirTarget;miRanda -0.292428262269443 0.00126336908744253 NA NA NA hsa-miR-374b-5p ITGAV 0.0804104684417872 0.365593963035077 -0.361899844330413 0.00011347300913332 mirMAP -0.157261944769125 0.00800336422382721 NA NA NA hsa-miR-29a-3p ITGB1 -0.431613225927952 4.10166815070288e-08 0.513228143004044 1.7455234981606e-12 MirTarget;miRNATAP -0.266903360917896 2.1799173467495e-07 26903137 hTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA 29a; We found that the up-regulation of hTERT in gastric cancer cells could inhibit the expression of miR-29a and enhance the expression of Integrin β1 ITGB1; Our study also found that the restoration of miR-29a suppressed the expression of ITGB1 and inhibited GC cell metastasis both in vitro and in vivo metastasis gastric cancer hsa-miR-29b-3p ITGB1 -0.228125979913806 0.0271621721891603 0.513228143004044 1.7455234981606e-12 MirTarget;miRNATAP -0.141683516314429 0.000421065810916977 NA NA NA hsa-miR-29c-3p ITGB1 -0.238671318446745 0.0141475322347596 0.513228143004044 1.7455234981606e-12 MirTarget;miRNATAP -0.250688699199018 2.20527026177669e-09 26766915 MiR 29c inhibits cell growth invasion and migration of pancreatic cancer by targeting ITGB1; Further analysis revealed that ITGB1 is one of the functional target genes of miR-29c and knockdown of ITGB1 inhibited the proliferation migration and invasion of PC cells which was similar to the effects of overexpression of miR-29c pancreatic cancer hsa-miR-429 ITGB1 -2.16569233119434 2.66862243626443e-37 0.513228143004044 1.7455234981606e-12 miRanda -0.159357819397413 2.51619184392234e-14 NA NA NA hsa-miR-185-5p ITGB3 1.05056378692621 1.31174187880682e-22 -1.16876127262302 4.47213898532844e-13 MirTarget -0.380827888713313 1.80757978703474e-06 NA NA NA hsa-miR-186-5p ITGB3 0.507217561043443 9.04455748270995e-10 -1.16876127262302 4.47213898532844e-13 mirMAP -0.287450613176695 0.00895994676850249 NA NA NA hsa-miR-28-5p ITGB3 0.461962042257226 3.32424690573327e-11 -1.16876127262302 4.47213898532844e-13 miRanda -0.618026759980789 1.73519014813362e-06 NA NA NA hsa-miR-589-5p ITGB3 0.696241532021631 5.26958362886071e-16 -1.16876127262302 4.47213898532844e-13 MirTarget -0.791365193458178 1.60125046389991e-15 NA NA NA hsa-miR-590-3p ITGB3 1.13702599385212 3.53435739887793e-22 -1.16876127262302 4.47213898532844e-13 PITA;miRanda -0.320338883173731 1.2408606013794e-05 NA NA NA hsa-miR-590-5p ITGB3 0.709763558412506 1.11883921359361e-11 -1.16876127262302 4.47213898532844e-13 miRanda -0.378575696987631 9.00644743494825e-06 NA NA NA hsa-miR-532-5p ITGB4 -1.09700348358668 8.34836230254408e-26 0.366657148889288 0.0170602838400261 miRNATAP -0.499059290266184 9.69706117529791e-12 NA NA NA hsa-miR-374a-3p ITGB5 1.13863935833993 2.79089304015401e-44 -0.251981418555273 0.000366030910909779 MirTarget -0.125509807214839 0.0028566990547544 NA NA NA hsa-miR-126-5p ITGB6 0.785607261431085 5.77058629454465e-13 -3.05700151063747 1.89056434825181e-30 MirTarget -0.816652963706394 6.77608997695021e-09 NA NA NA hsa-miR-144-3p ITGB6 1.4617706700291 9.18139413836375e-11 -3.05700151063747 1.89056434825181e-30 MirTarget -0.400970873661399 4.27570552875705e-09 NA NA NA hsa-miR-16-1-3p ITGB6 1.51429140700091 3.17219833254498e-37 -3.05700151063747 1.89056434825181e-30 mirMAP -0.775789243881654 1.11678317734551e-10 NA NA NA hsa-miR-17-5p ITGB6 0.494260110870015 3.8348005261e-09 -3.05700151063747 1.89056434825181e-30 TargetScan -0.678716066384561 0.000341348597367866 NA NA NA hsa-miR-197-3p ITGB6 0.297760714271229 0.00102679606305048 -3.05700151063747 1.89056434825181e-30 MirTarget -0.545075782278295 0.00228476209334042 NA NA NA hsa-miR-23a-3p ITGB6 0.761438723382355 4.09310879199257e-27 -3.05700151063747 1.89056434825181e-30 MirTarget -0.855735756274289 5.55599782109708e-05 NA NA NA hsa-miR-338-5p ITGB6 0.628429807914222 1.27575140717947e-06 -3.05700151063747 1.89056434825181e-30 mirMAP -0.535874022126912 1.64558898863624e-05 NA NA NA hsa-miR-590-3p ITGB6 1.13702599385212 3.53435739887793e-22 -3.05700151063747 1.89056434825181e-30 mirMAP -0.65110465266525 3.37778439944661e-07 NA NA NA hsa-miR-629-5p ITGB6 1.73389921851483 5.39614356468007e-48 -3.05700151063747 1.89056434825181e-30 MirTarget -0.942548022189834 3.00117240059669e-17 NA NA NA hsa-miR-7-1-3p ITGB6 0.544601828025304 5.33830451326047e-07 -3.05700151063747 1.89056434825181e-30 MirTarget -0.675647309936365 3.50675108579504e-06 NA NA NA hsa-miR-125a-3p ITGB7 -0.372794471295036 0.000941729459601642 0.787404467051897 2.9082147412094e-13 miRanda -0.177031502192572 0.00120780132858244 NA NA NA hsa-miR-106b-5p ITGB8 1.07509411417907 2.11739194181878e-36 -0.594449821425052 0.000368125011063098 MirTarget;miRNATAP -0.329535144063683 0.000722439353106813 NA NA NA hsa-miR-130b-3p ITGB8 1.12788913578446 2.939369462276e-16 -0.594449821425052 0.000368125011063098 MirTarget;miRNATAP -0.324138441893755 3.1761223141768e-07 NA NA NA hsa-miR-17-5p ITGB8 0.494260110870015 3.8348005261e-09 -0.594449821425052 0.000368125011063098 MirTarget;TargetScan;miRNATAP -0.321801438244596 0.00313986613252791 NA NA NA hsa-miR-181a-5p ITGB8 1.11111114875339 3.97880443756442e-29 -0.594449821425052 0.000368125011063098 miRNATAP -0.343835280548107 5.57358134993374e-05 NA NA NA hsa-miR-181b-5p ITGB8 1.49054296272357 3.69051660739368e-41 -0.594449821425052 0.000368125011063098 miRNATAP -0.261557330082209 0.000368020133513352 NA NA NA hsa-miR-19a-3p ITGB8 0.722913586880779 2.76301458932381e-10 -0.594449821425052 0.000368125011063098 MirTarget -0.335099117632457 1.92732158203645e-05 NA NA NA hsa-miR-19b-1-5p ITGB8 0.66692013055553 1.55789130176287e-09 -0.594449821425052 0.000368125011063098 miRNAWalker2_validate -0.230255358873881 0.0051943064031402 NA NA NA hsa-miR-19b-3p ITGB8 0.195940928879427 0.0300512922542325 -0.594449821425052 0.000368125011063098 MirTarget -0.348587203914171 0.000727679901767026 NA NA NA hsa-miR-20a-5p ITGB8 0.702602695798242 4.06372887613329e-13 -0.594449821425052 0.000368125011063098 MirTarget;miRNATAP -0.341722722111957 0.000217825392005956 NA NA NA hsa-miR-330-5p ITGB8 1.44960468659754 2.12131210588035e-45 -0.594449821425052 0.000368125011063098 MirTarget;miRanda;miRNATAP -0.269762735266132 0.000592142814893732 NA NA NA hsa-miR-361-5p ITGB8 0.0514169367202078 0.382929376393199 -0.594449821425052 0.000368125011063098 miRanda -0.534082481014022 0.000934548775912542 NA NA NA hsa-miR-576-5p ITGB8 1.06681109513983 5.69294424466526e-24 -0.594449821425052 0.000368125011063098 PITA -0.263657359516889 0.00126078040679565 NA NA NA hsa-miR-582-5p ITGB8 -0.323404837478908 0.0786820871592677 -0.594449821425052 0.000368125011063098 miRNATAP -0.25979005154925 1.87477653146213e-07 NA NA NA hsa-miR-590-3p ITGB8 1.13702599385212 3.53435739887793e-22 -0.594449821425052 0.000368125011063098 MirTarget;PITA;miRanda -0.233306824450734 0.00163198142192539 NA NA NA hsa-miR-590-5p ITGB8 0.709763558412506 1.11883921359361e-11 -0.594449821425052 0.000368125011063098 miRanda;miRNATAP -0.368827493531188 1.65281018127458e-05 NA NA NA hsa-miR-30b-5p JAK1 -1.18330589477119 6.8341618466966e-27 0.131794605189519 0.0301816038641141 MirTarget -0.154327762699697 1.98242713979809e-08 NA NA NA hsa-miR-139-5p JAK3 -0.704802495091118 2.36904108453776e-06 2.48026307004137 8.08540877822019e-45 miRanda -0.608452589439119 5.99295126216892e-18 NA NA NA hsa-miR-30b-3p JAK3 -1.64703050862226 1.89878531036464e-31 2.48026307004137 8.08540877822019e-45 MirTarget -0.801091421044252 1.53134081837362e-34 NA NA NA hsa-miR-335-5p JAK3 -2.09515619961552 1.03765771499548e-25 2.48026307004137 8.08540877822019e-45 miRNAWalker2_validate -0.228223837966963 1.09784040689687e-05 NA NA NA hsa-miR-149-5p KDR -1.95790336710741 8.46371715052367e-27 0.985118895051475 1.02914063123208e-08 miRNATAP -0.285208531235896 2.71184164647722e-09 NA NA NA hsa-miR-200b-3p KDR -1.70383252137161 2.38979336321755e-30 0.985118895051475 1.02914063123208e-08 miRNAWalker2_validate;miRTarBase;TargetScan -0.27162342475752 3.81432938994288e-06 NA NA NA hsa-miR-200c-3p KDR -5.40303134829523 2.74173143360645e-94 0.985118895051475 1.02914063123208e-08 miRNATAP -0.193548659793197 5.20778982168023e-13 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-335-5p KDR -2.09515619961552 1.03765771499548e-25 0.985118895051475 1.02914063123208e-08 miRNAWalker2_validate -0.236883657749445 1.08371410170902e-07 NA NA NA hsa-miR-429 KDR -2.16569233119434 2.66862243626443e-37 0.985118895051475 1.02914063123208e-08 PITA;miRanda;miRNATAP -0.202657874192441 6.11847457705003e-05 NA NA NA hsa-let-7f-1-3p KIT 0.477913872379336 4.46669616865068e-05 -2.21992984400247 1.58406195649638e-30 mirMAP -0.378337992988295 0.000431573662242811 NA NA NA hsa-miR-128-3p KIT 0.475045893035043 2.6255647468e-06 -2.21992984400247 1.58406195649638e-30 MirTarget -0.626155450841991 3.08580485383805e-08 NA NA NA hsa-miR-130b-3p KIT 1.12788913578446 2.939369462276e-16 -2.21992984400247 1.58406195649638e-30 miRNATAP -0.67929887508987 1.35655636281634e-18 NA NA NA hsa-miR-142-5p KIT 1.88417391525707 1.2096808039882e-27 -2.21992984400247 1.58406195649638e-30 PITA;miRNATAP -0.540689315093856 3.54841122745544e-20 NA NA NA hsa-miR-146b-5p KIT 1.40714170253819 2.9559871816487e-12 -2.21992984400247 1.58406195649638e-30 miRNAWalker2_validate -0.4457774999771 9.44953820156257e-17 NA NA NA hsa-miR-186-5p KIT 0.507217561043443 9.04455748270995e-10 -2.21992984400247 1.58406195649638e-30 miRNAWalker2_validate -0.868269314889548 1.7564876750562e-10 NA NA NA hsa-miR-193a-3p KIT 0.849206638484406 3.68101781083335e-14 -2.21992984400247 1.58406195649638e-30 MirTarget;PITA;miRanda;miRNATAP -0.672624908086957 6.91906460037293e-12 NA NA NA hsa-miR-195-3p KIT 0.808592887366705 6.8151241038711e-09 -2.21992984400247 1.58406195649638e-30 miRNATAP -0.279937786770183 0.00071287632494586 NA NA NA hsa-miR-19a-3p KIT 0.722913586880779 2.76301458932381e-10 -2.21992984400247 1.58406195649638e-30 miRTarBase;miRNATAP -0.602700425289326 7.00869649151469e-10 NA NA NA hsa-miR-19b-3p KIT 0.195940928879427 0.0300512922542325 -2.21992984400247 1.58406195649638e-30 miRNATAP -0.476954724802295 0.000253004442771608 NA NA NA hsa-miR-20a-5p KIT 0.702602695798242 4.06372887613329e-13 -2.21992984400247 1.58406195649638e-30 miRTarBase -0.604373490728516 1.77119512817736e-07 NA NA NA hsa-miR-301a-3p KIT 0.259400847075798 0.0216890736701418 -2.21992984400247 1.58406195649638e-30 miRNATAP -0.561470220020192 4.14396084155108e-08 NA NA NA hsa-miR-338-3p KIT 0.906250377628867 2.76970900371139e-15 -2.21992984400247 1.58406195649638e-30 miRanda -0.325225663119539 0.000900259125510807 NA NA NA hsa-miR-342-3p KIT 1.4124432570595 1.07208971556131e-28 -2.21992984400247 1.58406195649638e-30 miRanda -0.769676396309162 2.90516819271403e-22 NA NA NA hsa-miR-34a-5p KIT 1.07544567720768 1.81510842038009e-20 -2.21992984400247 1.58406195649638e-30 MirTarget -0.713227505166628 7.27672715727417e-15 NA NA NA hsa-miR-421 KIT 0.313155739887734 0.020433534776003 -2.21992984400247 1.58406195649638e-30 miRanda -0.352939367438444 7.61398922778979e-05 NA NA NA hsa-miR-450b-5p KIT 0.404819502355575 0.00357671373841274 -2.21992984400247 1.58406195649638e-30 MirTarget -0.254346785524299 0.00250879082300239 NA NA NA hsa-miR-454-3p KIT 0.68285296887698 1.17407812677787e-08 -2.21992984400247 1.58406195649638e-30 miRNATAP -0.69150058557585 8.86986795393098e-14 NA NA NA hsa-miR-505-3p KIT -0.0591326765593969 0.556908871953633 -2.21992984400247 1.58406195649638e-30 MirTarget;miRNATAP -0.311107178796799 0.00818234538972183 NA NA NA hsa-miR-590-3p KIT 1.13702599385212 3.53435739887793e-22 -2.21992984400247 1.58406195649638e-30 miRanda;mirMAP -0.690614524740843 2.07558876015919e-14 NA NA NA hsa-miR-671-5p KIT 0.740296481994777 8.07053661008188e-07 -2.21992984400247 1.58406195649638e-30 MirTarget -0.325854888238492 2.5099309324694e-05 NA NA NA hsa-miR-1270 KITLG 1.71697026896618 1.75919401373445e-16 -1.86297449161736 3.98973030513653e-32 MirTarget;PITA -0.256523375868721 2.93369022853655e-09 NA NA NA hsa-miR-142-5p KITLG 1.88417391525707 1.2096808039882e-27 -1.86297449161736 3.98973030513653e-32 MirTarget;PITA -0.433836055341139 3.12640800994414e-19 NA NA NA hsa-miR-144-3p KITLG 1.4617706700291 9.18139413836375e-11 -1.86297449161736 3.98973030513653e-32 MirTarget -0.17632163671727 1.82879393114234e-05 NA NA NA hsa-miR-17-3p KITLG 0.723795600017259 5.90151677164931e-18 -1.86297449161736 3.98973030513653e-32 MirTarget -0.587849267098174 5.4837481938984e-08 NA NA NA hsa-miR-181a-5p KITLG 1.11111114875339 3.97880443756442e-29 -1.86297449161736 3.98973030513653e-32 MirTarget -0.398430294974858 6.49026906724375e-06 NA NA NA hsa-miR-181b-5p KITLG 1.49054296272357 3.69051660739368e-41 -1.86297449161736 3.98973030513653e-32 MirTarget -0.447122201638632 2.44640753459748e-09 NA NA NA hsa-miR-185-5p KITLG 1.05056378692621 1.31174187880682e-22 -1.86297449161736 3.98973030513653e-32 miRNAWalker2_validate -0.524717768158724 1.5686558262394e-10 NA NA NA hsa-miR-186-5p KITLG 0.507217561043443 9.04455748270995e-10 -1.86297449161736 3.98973030513653e-32 mirMAP -0.602936844388262 8.88156820272543e-08 NA NA NA hsa-miR-192-3p KITLG 0.156650099616707 0.483496040900362 -1.86297449161736 3.98973030513653e-32 mirMAP -0.170795026079867 7.43022213984735e-05 NA NA NA hsa-miR-19a-3p KITLG 0.722913586880779 2.76301458932381e-10 -1.86297449161736 3.98973030513653e-32 mirMAP -0.437730576327869 5.98884192970255e-08 NA NA NA hsa-miR-19b-3p KITLG 0.195940928879427 0.0300512922542325 -1.86297449161736 3.98973030513653e-32 mirMAP -0.374083488237465 0.000478141871982586 NA NA NA hsa-miR-22-5p KITLG -0.197038086012602 0.106234828461117 -1.86297449161736 3.98973030513653e-32 MirTarget -0.287665820873746 0.000267866869699266 NA NA NA hsa-miR-23a-3p KITLG 0.761438723382355 4.09310879199257e-27 -1.86297449161736 3.98973030513653e-32 mirMAP -0.786272343851677 2.37257817570825e-10 NA NA NA hsa-miR-28-3p KITLG 1.01277915413238 1.8655970171461e-43 -1.86297449161736 3.98973030513653e-32 mirMAP -1.01158017808329 2.30714084424531e-20 NA NA NA hsa-miR-320a KITLG 0.412740558379182 2.02929519701706e-05 -1.86297449161736 3.98973030513653e-32 MirTarget;PITA;miRanda -0.293228822980955 0.00304289482425239 NA NA NA hsa-miR-320b KITLG 0.300497419754843 0.0245219177384172 -1.86297449161736 3.98973030513653e-32 MirTarget;PITA;miRanda -0.218416855646807 0.00243832580112543 NA NA NA hsa-miR-330-3p KITLG 0.912906550436308 3.35037014057665e-13 -1.86297449161736 3.98973030513653e-32 MirTarget -0.253883065531183 0.000783948955343714 NA NA NA hsa-miR-34a-5p KITLG 1.07544567720768 1.81510842038009e-20 -1.86297449161736 3.98973030513653e-32 MirTarget -0.500881702059111 5.08151200066889e-11 NA NA NA hsa-miR-374a-5p KITLG 0.543061152108237 2.19403097299769e-14 -1.86297449161736 3.98973030513653e-32 mirMAP -0.647162783955817 6.74981228595456e-07 NA NA NA hsa-miR-374b-5p KITLG 0.0804104684417872 0.365593963035077 -1.86297449161736 3.98973030513653e-32 mirMAP -0.312753277150362 0.00430864198858304 NA NA NA hsa-miR-452-3p KITLG 1.72039996672257 1.35748079442153e-22 -1.86297449161736 3.98973030513653e-32 mirMAP -0.279633052201587 5.07714226373034e-08 NA NA NA hsa-miR-590-3p KITLG 1.13702599385212 3.53435739887793e-22 -1.86297449161736 3.98973030513653e-32 MirTarget;PITA;miRanda -0.612277214280404 8.49694871328764e-17 NA NA NA hsa-miR-7-1-3p KITLG 0.544601828025304 5.33830451326047e-07 -1.86297449161736 3.98973030513653e-32 mirMAP -0.380080722704913 1.21476017966841e-05 NA NA NA hsa-let-7a-3p KRAS 0.0677487960013088 0.460458477653989 -0.255817061539648 9.1459633191595e-05 mirMAP;miRNATAP -0.135776810220158 0.000642882403233645 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-miR-140-3p KRAS 0.989350547007025 6.14964028267239e-25 -0.255817061539648 9.1459633191595e-05 MirTarget -0.108294077444579 0.00207293957432564 NA NA NA hsa-miR-193a-3p KRAS 0.849206638484406 3.68101781083335e-14 -0.255817061539648 9.1459633191595e-05 MirTarget;miRanda;miRNATAP -0.128321272108433 3.45488258543067e-05 NA NA NA hsa-miR-193a-5p KRAS 1.29777740059595 2.16815694068336e-39 -0.255817061539648 9.1459633191595e-05 miRNATAP -0.131260938035955 4.98455580646047e-05 NA NA NA hsa-miR-27a-3p KRAS 0.558934437526245 1.44256383086177e-12 -0.255817061539648 9.1459633191595e-05 miRNATAP -0.185157688434118 3.18082458260436e-05 24154848;25436011 microRNA 27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS; Furthermore we demonstrated that miR-27a binds to the 3'-untranslated region UTR of KRAS and inhibits the expression of the KRAS protein; miR-27a levels were inversely correlated with levels of KRAS mRNA and protein in ESCC specimens; Our findings suggest for the first time that miR-27a suppresses tumorigenesis of ESCC by targeting KRAS;MicroRNA 27a directly targets KRAS to inhibit cell proliferation in esophageal squamous cell carcinoma; However the expression level of the target gene KRAS was upregulated and ESCC cell proliferation was significantly inhibited following miR-27a mimic or small interfering K-ras transfection; In conclusion the present study demonstrated that the expression level of miR-27a was low in ESCC and that miR-27a directly targets the KRAS gene resulting in inhibited cell proliferation in esophageal cancer tumorigenesis; esophageal cancer;esophageal cancer hsa-miR-542-3p KRAS 0.431147917094433 0.000254981247606435 -0.255817061539648 9.1459633191595e-05 miRanda -0.102463772502373 0.00079256513841055 NA NA NA hsa-miR-146b-5p LAMA2 1.40714170253819 2.9559871816487e-12 -2.4271590687032 5.37760256830424e-23 miRanda -0.211187780161961 0.00241983525398163 NA NA NA hsa-miR-590-3p LAMA2 1.13702599385212 3.53435739887793e-22 -2.4271590687032 5.37760256830424e-23 miRanda -0.6633279491368 6.24057756600592e-09 NA NA NA hsa-miR-125a-3p LAMA3 -0.372794471295036 0.000941729459601642 0.577410935053985 8.68292293363872e-05 miRanda -0.191972986583435 0.00830423746226377 NA NA NA hsa-miR-125a-5p LAMA4 -0.561874059994802 7.3931856356891e-13 2.91545426900544 3.08985953142452e-65 miRanda -0.569688628830193 6.96066990619898e-05 NA NA NA hsa-miR-188-5p LAMA4 -1.74586655806628 1.50431624674552e-28 2.91545426900544 3.08985953142452e-65 miRNATAP -0.768061917189418 7.89909325668188e-35 NA NA NA hsa-miR-429 LAMA4 -2.16569233119434 2.66862243626443e-37 2.91545426900544 3.08985953142452e-65 miRanda -0.642991530727814 1.94055613855085e-31 NA NA NA hsa-miR-539-5p LAMA4 -1.44841597031461 8.25650852878567e-11 2.91545426900544 3.08985953142452e-65 MirTarget -0.174730256877997 0.000714089827993529 NA NA NA hsa-miR-335-5p LAMA5 -2.09515619961552 1.03765771499548e-25 0.629789213374421 3.84885830096106e-08 miRNAWalker2_validate -0.148450813270589 5.67961561526111e-07 NA NA NA hsa-miR-29b-1-5p LAMB2 0.0773574972948876 0.542823265430415 0.229006201741834 0.0141673622104033 MirTarget -0.118767085661085 0.00352418196960068 NA NA NA hsa-miR-16-5p LAMB3 0.934012514027655 4.85417898318515e-24 -0.505094651206311 0.0298998234787328 miRNAWalker2_validate -0.396268107656207 0.00230380042172987 NA NA NA hsa-miR-590-3p LAMB4 1.13702599385212 3.53435739887793e-22 -3.19125521275145 2.27599893375638e-42 miRanda -0.726559317701284 2.8529101894462e-10 NA NA NA hsa-miR-107 LAMC1 0.140046250553248 0.0943611632552367 0.635416495630585 3.74602393524152e-13 miRanda -0.356998455033202 1.51354896546459e-09 NA NA NA hsa-miR-188-5p LAMC1 -1.74586655806628 1.50431624674552e-28 0.635416495630585 3.74602393524152e-13 MirTarget -0.233399116501937 4.14059870201399e-16 NA NA NA hsa-miR-193b-3p LAMC1 -0.273325765316079 0.104328826585392 0.635416495630585 3.74602393524152e-13 MirTarget -0.109330671932415 0.000220228840950065 NA NA NA hsa-miR-200b-3p LAMC1 -1.70383252137161 2.38979336321755e-30 0.635416495630585 3.74602393524152e-13 MirTarget;TargetScan -0.196024438912367 4.56764179933925e-11 NA NA NA hsa-miR-22-3p LAMC1 0.198460552200729 0.00761005672059428 0.635416495630585 3.74602393524152e-13 MirTarget;miRNATAP -0.277437526606205 4.00267627669617e-05 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29a-3p LAMC1 -0.431613225927952 4.10166815070288e-08 0.635416495630585 3.74602393524152e-13 MirTarget;miRNATAP -0.28682179968968 4.28193030377521e-06 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29b-3p LAMC1 -0.228125979913806 0.0271621721891603 0.635416495630585 3.74602393524152e-13 MirTarget;miRNATAP -0.20056094366702 3.27529894162567e-05 NA NA NA hsa-miR-29c-3p LAMC1 -0.238671318446745 0.0141475322347596 0.635416495630585 3.74602393524152e-13 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.333942940925805 2.97674000981545e-11 NA NA NA hsa-miR-362-3p LAMC1 -0.753214251798232 3.0025661608035e-07 0.635416495630585 3.74602393524152e-13 miRanda -0.214832155546576 1.75815413222915e-10 NA NA NA hsa-miR-374b-5p LAMC1 0.0804104684417872 0.365593963035077 0.635416495630585 3.74602393524152e-13 mirMAP -0.182761708008844 0.00128421088165845 NA NA NA hsa-miR-429 LAMC1 -2.16569233119434 2.66862243626443e-37 0.635416495630585 3.74602393524152e-13 MirTarget;PITA;miRanda;miRNATAP -0.194389787205348 1.21390474944864e-14 NA NA NA hsa-miR-148b-3p LAMC2 0.346011252093377 4.27203463315056e-06 -2.46092405865136 1.8652143818936e-17 miRNAWalker2_validate -0.66664092810126 0.00285317312072829 NA NA NA hsa-miR-338-3p LAMC2 0.906250377628867 2.76970900371139e-15 -2.46092405865136 1.8652143818936e-17 miRanda -0.805513316218237 5.37762850839552e-09 NA NA NA hsa-miR-338-5p LAMC2 0.628429807914222 1.27575140717947e-06 -2.46092405865136 1.8652143818936e-17 mirMAP -0.4632654300985 0.000364208008352244 NA NA NA hsa-miR-342-3p LAMC2 1.4124432570595 1.07208971556131e-28 -2.46092405865136 1.8652143818936e-17 miRanda -0.524757063210548 1.30108235280438e-05 NA NA NA hsa-miR-590-3p LAMC2 1.13702599385212 3.53435739887793e-22 -2.46092405865136 1.8652143818936e-17 miRanda;mirMAP -0.737606678200318 2.44235870305358e-08 NA NA NA hsa-miR-590-5p LAMC2 0.709763558412506 1.11883921359361e-11 -2.46092405865136 1.8652143818936e-17 miRanda -0.743355453275857 1.58765147817913e-06 NA NA NA hsa-miR-130b-3p LAMC3 1.12788913578446 2.939369462276e-16 -1.42602066207616 1.11124743151624e-08 mirMAP -0.30124867256618 0.00201388990979763 NA NA NA hsa-miR-185-3p LAMC3 0.993379985307475 2.62011454953707e-13 -1.42602066207616 1.11124743151624e-08 mirMAP -0.328740560641078 0.00116917673101075 NA NA NA hsa-miR-192-5p LAMC3 0.442478872410106 0.0669238175123954 -1.42602066207616 1.11124743151624e-08 mirMAP -0.210896773061747 0.00027565216219208 NA NA NA hsa-miR-2355-5p LAMC3 1.57515081110162 3.54962327490702e-48 -1.42602066207616 1.11124743151624e-08 mirMAP -0.326071247640539 0.00373723766542786 NA NA NA hsa-miR-330-5p LAMC3 1.44960468659754 2.12131210588035e-45 -1.42602066207616 1.11124743151624e-08 MirTarget;miRanda -0.572741671829112 1.27369071362876e-06 NA NA NA hsa-miR-425-5p LAMC3 0.146116356753256 0.318699399094984 -1.42602066207616 1.11124743151624e-08 mirMAP -0.326868509441446 0.00067377883456717 NA NA NA hsa-miR-452-5p LAMC3 2.05325688842141 2.82238393643084e-40 -1.42602066207616 1.11124743151624e-08 mirMAP -0.2706337876699 0.000731980696765532 NA NA NA hsa-miR-23a-3p LPAR1 0.761438723382355 4.09310879199257e-27 -1.37726148622194 1.93140558548801e-11 MirTarget;miRNATAP -0.589418463953401 0.000123704818387253 NA NA NA hsa-miR-338-5p LPAR1 0.628429807914222 1.27575140717947e-06 -1.37726148622194 1.93140558548801e-11 MirTarget;miRNATAP -0.403984030765716 6.74541780587708e-06 NA NA NA hsa-miR-361-5p LPAR1 0.0514169367202078 0.382929376393199 -1.37726148622194 1.93140558548801e-11 miRanda -0.5693988832943 0.0052327049548074 NA NA NA hsa-miR-452-5p LPAR1 2.05325688842141 2.82238393643084e-40 -1.37726148622194 1.93140558548801e-11 MirTarget -0.352852388549924 7.50478788109358e-08 NA NA NA hsa-miR-429 LPAR5 -2.16569233119434 2.66862243626443e-37 2.33228840309028 4.95118905552068e-42 miRanda;miRNATAP -0.403900237775086 1.55787954730504e-13 NA NA NA hsa-miR-874-3p LPAR5 -1.50243370621573 8.39418307315909e-25 2.33228840309028 4.95118905552068e-42 MirTarget -0.45715071520394 6.83330408880445e-12 NA NA NA hsa-miR-27b-3p LPAR6 -0.699527231242518 1.07356023759234e-15 1.10457459989507 7.68232001102784e-22 MirTarget;miRNATAP -0.314289915878038 2.31676912785839e-05 NA NA NA hsa-let-7a-3p MAPK1 0.0677487960013088 0.460458477653989 0.0752350253994916 0.244227817396104 mirMAP -0.120937214673988 0.00189910022756462 NA NA NA hsa-miR-221-3p MAPK1 0.337895669520713 0.0136448974691037 0.0752350253994916 0.244227817396104 mirMAP -0.18533006750384 1.05774724669662e-13 NA NA NA hsa-miR-222-3p MAPK1 0.214811008033524 0.0965295551752457 0.0752350253994916 0.244227817396104 mirMAP -0.111381984547009 4.49766515770734e-05 NA NA NA hsa-miR-29a-3p MAPK1 -0.431613225927952 4.10166815070288e-08 0.0752350253994916 0.244227817396104 mirMAP -0.199785129647306 6.26938786529944e-06 NA NA NA hsa-miR-29c-3p MAPK1 -0.238671318446745 0.0141475322347596 0.0752350253994916 0.244227817396104 mirMAP -0.118476374132015 0.00117661250325827 NA NA NA hsa-miR-30b-5p MAPK1 -1.18330589477119 6.8341618466966e-27 0.0752350253994916 0.244227817396104 mirMAP -0.126400578163208 1.7728740776704e-05 NA NA NA hsa-miR-22-5p MCL1 -0.197038086012602 0.106234828461117 0.138183224211392 0.0903806958136723 mirMAP -0.118172974778421 0.00134704605270069 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29a-3p MCL1 -0.431613225927952 4.10166815070288e-08 0.138183224211392 0.0903806958136723 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.149558998536497 0.00825773749070765 26052614;20041405;21471522;24155920;23484699 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs;Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29;MiR 29a down regulation in ALK positive anaplastic large cell lymphomas contributes to apoptosis blockade through MCL 1 overexpression; In addition we showed that low expression of miR-29a probably through methylation repression plays an important regulatory role in MCL-1 overexpression that could promote tumor cell survival by inhibiting apoptosis; Enforced miR-29a expression was found to modulate apoptosis through inhibition of MCL-1 expression in ALCL cell lines and in a xenografted model with a concomitant tumor growth reduction;Finally miR-29a and miR-29b targeted MCL1 mRNA in GICs and increased apoptosis;Expression of MCL 1 and microRNA 29a in extranodal NK/T cell lymphoma tissue; This study was aimed to explore the expression level and correlation of MCL-1 and miR-29a in extranodal NK/T-cell lymphoma ENKTCL tissue; Maxvision immunohistochemistry technique and real time fluorescent quantitative PCR were used to detect the expression level of MCL-1 and miR-29a in tissue of 20 patients with ENKTCL and 10 patients with proliferative lymphadenitis respectively; Correlation analysis indicated that there was significant negative correlation between miR-29a expression and MCL-1 expression r = -0.59 P = 0.016; It is concluded that miR-29a may target MCL-1 gene regulate its expression then participate in tumorigenesis and development of ENKTCL ;;poor survival;;tumorigenesis prostate cancer;liver cancer;lymphoma;glioblastoma;lymphoma hsa-miR-145-5p MDM2 -0.459160400949571 0.000776344261622237 0.793190906694193 8.44776116028465e-23 miRNAWalker2_validate -0.147065370036944 1.95227314117328e-05 NA NA NA hsa-miR-23b-3p MDM2 -0.533749586990474 2.46924776953771e-10 0.793190906694193 8.44776116028465e-23 mirMAP -0.315717493386307 6.44067502421801e-09 NA NA NA hsa-miR-26b-5p MDM2 -0.251437253429904 0.00270935785098697 0.793190906694193 8.44776116028465e-23 miRNAWalker2_validate -0.200227881151587 0.000439991070511547 NA NA NA hsa-miR-374b-5p MDM2 0.0804104684417872 0.365593963035077 0.793190906694193 8.44776116028465e-23 mirMAP -0.208884138903245 0.000106081838021418 NA NA NA hsa-miR-429 MDM2 -2.16569233119434 2.66862243626443e-37 0.793190906694193 8.44776116028465e-23 miRanda -0.140702422709165 9.18245159970993e-09 NA NA NA hsa-miR-500a-5p MDM2 -1.28374735824553 1.95870374809798e-20 0.793190906694193 8.44776116028465e-23 mirMAP -0.190652593253116 1.86314563864775e-09 NA NA NA hsa-miR-125a-3p MET -0.372794471295036 0.000941729459601642 1.10521139840773 5.81097310030977e-21 miRanda -0.284444298057698 2.77787407081191e-06 NA NA NA hsa-miR-127-3p MET -1.21389348740811 1.68387193137287e-11 1.10521139840773 5.81097310030977e-21 miRanda -0.174598343093179 1.95935669805614e-06 NA NA NA hsa-miR-130a-3p MET -0.667386596699886 1.34029167767774e-10 1.10521139840773 5.81097310030977e-21 miRNAWalker2_validate -0.22362307667284 0.000557058482784787 NA NA NA hsa-miR-139-5p MET -0.704802495091118 2.36904108453776e-06 1.10521139840773 5.81097310030977e-21 miRanda -0.246239292765101 4.1364380758207e-08 NA NA NA hsa-miR-199a-3p MET -1.61607426368083 1.97964980193147e-26 1.10521139840773 5.81097310030977e-21 miRNAWalker2_validate;miRTarBase -0.231567821676256 1.91977917623346e-08 21055388;25839163 16 2002 3074-3086 and c-Met is a known miR-199a-3p target we hypothesized that miR-199a-3p may also target CD44;In silico analyses indicated that MET is one of the target genes for miR-199a-3p; subsequently miR-199a-3p expression was found to be inversely correlated with c-Met expression in ovarian cancer; Transfection of precursor miR-199a-3p into ovarian cancer cells reduced c-Met expression and inhibited the phosphorylation of c-Met extracellular signal-regulated kinase and AKT; in addition proliferation adhesion and invasiveness were inhibited; In summary the hypoxia-related microRNA miR-199a-3p drastically inhibits ovarian cancer progression through the downregulation of c-Met expression ;progression liver cancer;ovarian cancer hsa-miR-23b-3p MET -0.533749586990474 2.46924776953771e-10 1.10521139840773 5.81097310030977e-21 miRNAWalker2_validate;miRTarBase -0.288449648692482 0.000322376434190187 19490101 MicroRNA 23b mediates urokinase and c met downmodulation and a decreased migration of human hepatocellular carcinoma cells; In the present study to understand whether the expression of these genes might be coregulated by specific microRNAs miRs in human cells we predicted that Homo sapiens microRNA-23b could recognize two sites in the 3'-UTR of uPA and four sites in the c-met 3'-UTR by the algorithm pictar; The evidence obtained shows that overexpression of miR-23b leads to uPA and c-met downregulation and to decreased migration and proliferation abilities of HCC cells liver cancer hsa-miR-30a-3p MET -0.955360819934585 1.97009535429185e-20 1.10521139840773 5.81097310030977e-21 mirMAP -0.223584517664621 0.000396332171778455 NA NA NA hsa-miR-30d-3p MET -0.249777194282131 0.00235356711813496 1.10521139840773 5.81097310030977e-21 mirMAP -0.262253658982834 0.00194187018539678 NA NA NA hsa-miR-30e-3p MET -0.205602546270795 0.00132666419729688 1.10521139840773 5.81097310030977e-21 mirMAP -0.350613138955605 0.00135280320964367 NA NA NA hsa-miR-361-5p MET 0.0514169367202078 0.382929376393199 1.10521139840773 5.81097310030977e-21 PITA;miRanda -0.39809738988012 0.0009365276679273 NA NA NA hsa-miR-362-3p MET -0.753214251798232 3.0025661608035e-07 1.10521139840773 5.81097310030977e-21 miRanda -0.235463896413951 5.79434472506528e-07 NA NA NA hsa-miR-374b-5p MET 0.0804104684417872 0.365593963035077 1.10521139840773 5.81097310030977e-21 mirMAP -0.227462487419821 0.00381082169623714 NA NA NA hsa-miR-532-3p MET -1.759223962964 7.9077916669414e-40 1.10521139840773 5.81097310030977e-21 PITA -0.339739753385223 1.34105177061007e-14 NA NA NA hsa-miR-125a-3p MTCP1 -0.372794471295036 0.000941729459601642 2.23355014162711 3.25236060171514e-44 PITA;miRanda;miRNATAP -0.32105918850478 0.000350009598558772 NA NA NA hsa-miR-127-3p MTCP1 -1.21389348740811 1.68387193137287e-11 2.23355014162711 3.25236060171514e-44 PITA;miRanda -0.334447199059032 3.32939575656018e-10 NA NA NA hsa-miR-26b-5p MTCP1 -0.251437253429904 0.00270935785098697 2.23355014162711 3.25236060171514e-44 miRNAWalker2_validate -0.34830863720638 0.00426251057852929 NA NA NA hsa-miR-429 MTCP1 -2.16569233119434 2.66862243626443e-37 2.23355014162711 3.25236060171514e-44 miRanda;miRNATAP -0.375967740315911 2.64935022009399e-13 NA NA NA hsa-miR-628-5p MTCP1 -0.293936745442736 0.0769541076905808 2.23355014162711 3.25236060171514e-44 PITA;miRNATAP -0.176943903897968 0.00378113431519189 NA NA NA hsa-miR-101-3p MTOR 0.683973909682285 2.88573524246948e-15 -1.15645195656852 1.96903920572283e-60 miRNATAP -0.339148730672481 2.53633456814317e-11 25480586;20805506 Meanwhile bioinformatic analysis demonstrated that mTOR gene was a direct target of miR-101; Overexpression of miR-101 significantly decreased the expression of mTOR at both mRNA and protein levels in Saos-2 cells consequently inhibiting Saos-2 cells proliferation and promoting cells apoptosis in an mTOR-dependent manner; mTOR plays an important role in mediating miR-101 dependent biological functions in osteosarcoma; Reintroduction of miR-101 may be a novel therapeutic strategy by down-regulating mTOR expression;Furthermore inhibition of mTOR which is targeted by miR-101 led to reduced tumor growth in engrafted ALCL mouse models ; sarcoma;lymphoma hsa-miR-1271-5p MTOR 0.900599702972936 3.07963385418853e-10 -1.15645195656852 1.96903920572283e-60 MirTarget -0.116688209061447 0.000244255416310915 26692935 Here we analyzed the levels of miR-1271 and mTor in NSCLC specimens and studied their correlation; We performed bioinformatics analysis and luciferase-reporter assay to study the association of miR-1271 with mTor mRNA; We analyzed miR-1271 levels in NSCLC cells and studied their effects on mTor levels; We detected significantly higher levels of mTor and significantly lower levels of miR-1271 in the NSCLC specimens compared to the paired non-tumor lung tissues; We found that miR-1271 bound to the 3'UTR of mTor mRNA to prevent its translation; Together these data suggest that in NSCLC miR-1271 may inhibit the cancer cell growth through mTor suppression lung squamous cell cancer hsa-miR-140-5p MTOR 0.504309496243674 3.09884038729031e-11 -1.15645195656852 1.96903920572283e-60 miRanda -0.378704054979172 1.57412670408321e-10 NA NA NA hsa-miR-16-5p MTOR 0.934012514027655 4.85417898318515e-24 -1.15645195656852 1.96903920572283e-60 miRNAWalker2_validate -0.383259499041904 2.60403416197894e-17 NA NA NA hsa-miR-181b-5p MTOR 1.49054296272357 3.69051660739368e-41 -1.15645195656852 1.96903920572283e-60 miRNAWalker2_validate -0.403310576622348 6.14330018148749e-33 NA NA NA hsa-miR-139-5p MYB -0.704802495091118 2.36904108453776e-06 2.6806521869588 4.47950352681659e-30 miRanda -0.331621561644056 0.000411456993273934 NA NA NA hsa-miR-200b-3p MYB -1.70383252137161 2.38979336321755e-30 2.6806521869588 4.47950352681659e-30 TargetScan -0.594349880741946 2.0571744113841e-12 NA NA NA hsa-miR-200c-3p MYB -5.40303134829523 2.74173143360645e-94 2.6806521869588 4.47950352681659e-30 miRNATAP -0.388679007180105 1.00816080296641e-24 NA NA NA hsa-miR-335-3p MYB -1.36498175550207 6.84287752180534e-13 2.6806521869588 4.47950352681659e-30 mirMAP -0.209187818429768 0.00386690005703024 NA NA NA hsa-miR-362-3p MYB -0.753214251798232 3.0025661608035e-07 2.6806521869588 4.47950352681659e-30 miRanda -0.267176533439079 0.0066884620479936 NA NA NA hsa-miR-429 MYB -2.16569233119434 2.66862243626443e-37 2.6806521869588 4.47950352681659e-30 PITA;miRanda;miRNATAP -0.481369875687843 3.63834314254657e-11 NA NA NA hsa-miR-501-5p MYB -1.1103073934745 1.81589804886553e-16 2.6806521869588 4.47950352681659e-30 PITA;miRNATAP -0.475053117033952 1.93125098517959e-06 NA NA NA hsa-miR-532-3p MYB -1.759223962964 7.9077916669414e-40 2.6806521869588 4.47950352681659e-30 miRNATAP -0.714401963309226 3.68781371514498e-15 NA NA NA hsa-miR-577 MYB -1.48881999472397 7.03080165111147e-10 2.6806521869588 4.47950352681659e-30 PITA -0.332247716255334 4.32663217930781e-09 NA NA NA hsa-let-7g-5p MYC -0.739744008507763 1.07979566264383e-14 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate;miRTarBase -0.398905767136213 2.71236287032834e-05 NA NA NA hsa-miR-135a-5p MYC -2.13422485001223 6.29449029671498e-14 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.108827259333515 0.000903589484065675 23176581 Moreover based on the results of this analysis we investigated whether miR-135a targeted the c-MYC gene in RCC; Gain-of-function and luciferase reporter assays showed that c-MYC was directly regulated by miR-135a in RCC cells kidney renal cell cancer hsa-miR-335-5p MYC -2.09515619961552 1.03765771499548e-25 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.216426299788151 7.62566723121896e-07 NA NA NA hsa-miR-429 MYC -2.16569233119434 2.66862243626443e-37 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.389721783902253 2.72292816859272e-16 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-744-5p MYC -0.348985243196771 0.000187889982228835 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.377458526504721 0.000190443255959769 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-let-7g-5p NGF -0.739744008507763 1.07979566264383e-14 1.68176218451818 4.25883926715749e-21 MirTarget -0.604104636667389 5.7443559092026e-09 NA NA NA hsa-miR-429 NGF -2.16569233119434 2.66862243626443e-37 1.68176218451818 4.25883926715749e-21 miRanda -0.274846404242145 4.10102515693054e-07 NA NA NA hsa-miR-148b-5p NGFR 0.269550343699955 0.0383631776794927 1.73595423231764 2.74915553479934e-17 mirMAP -0.258433454043494 0.00635621942669257 NA NA NA hsa-miR-30b-3p NGFR -1.64703050862226 1.89878531036464e-31 1.73595423231764 2.74915553479934e-17 mirMAP -0.447874831071752 3.12016672638388e-09 NA NA NA hsa-miR-335-5p NGFR -2.09515619961552 1.03765771499548e-25 1.73595423231764 2.74915553479934e-17 miRNAWalker2_validate -0.273692690787194 6.2535727522281e-07 NA NA NA hsa-miR-429 NGFR -2.16569233119434 2.66862243626443e-37 1.73595423231764 2.74915553479934e-17 miRNATAP -0.257757541818778 3.27230306859199e-05 NA NA NA hsa-miR-625-5p NGFR 0.153090549230629 0.330314026509869 1.73595423231764 2.74915553479934e-17 mirMAP -0.38340250894736 2.51016761080774e-06 NA NA NA hsa-miR-766-3p NGFR -0.230617949950715 0.0566289375252083 1.73595423231764 2.74915553479934e-17 mirMAP -0.54139859448209 2.47996756160292e-08 NA NA NA hsa-miR-93-5p NR4A1 1.37365940377595 2.37567548683245e-46 -1.28964885901639 4.74745690194872e-08 miRNAWalker2_validate -0.647466848675217 4.3635401018505e-08 NA NA NA hsa-miR-26a-5p NRAS -0.202091714279613 0.00166918288801054 0.34448791512356 4.92740995926564e-07 mirMAP;miRNATAP -0.190676842662057 0.00158798186993403 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-27b-3p NRAS -0.699527231242518 1.07356023759234e-15 0.34448791512356 4.92740995926564e-07 miRNATAP -0.133554182026992 0.00155260770161313 NA NA NA hsa-miR-29a-3p NRAS -0.431613225927952 4.10166815070288e-08 0.34448791512356 4.92740995926564e-07 miRNATAP -0.260252250919602 4.11630497908065e-08 NA NA NA hsa-miR-29c-3p NRAS -0.238671318446745 0.0141475322347596 0.34448791512356 4.92740995926564e-07 miRNATAP -0.171085903480696 1.27586236636451e-05 NA NA NA hsa-miR-502-3p NRAS -1.10416310320528 1.55354569985732e-22 0.34448791512356 4.92740995926564e-07 MirTarget -0.127167715752408 5.47705696881981e-05 NA NA NA hsa-miR-142-3p NTF3 1.88928758773299 2.72985643829893e-22 -0.668855124592218 0.000140030636687871 miRanda -0.192970372635885 3.40296027412e-05 NA NA NA hsa-miR-21-5p NTF3 2.51462371613332 3.30620591950316e-66 -0.668855124592218 0.000140030636687871 miRTarBase;miRNATAP -0.202004999552495 0.000189117552740546 NA NA NA hsa-miR-221-3p NTF3 0.337895669520713 0.0136448974691037 -0.668855124592218 0.000140030636687871 miRNATAP -0.191983307441267 0.00712732397760743 NA NA NA hsa-miR-222-3p NTF3 0.214811008033524 0.0965295551752457 -0.668855124592218 0.000140030636687871 miRNATAP -0.286460458871947 0.000146481856047174 NA NA NA hsa-miR-590-3p NTF3 1.13702599385212 3.53435739887793e-22 -0.668855124592218 0.000140030636687871 miRanda -0.280720029817671 0.000312503544564494 NA NA NA hsa-miR-590-5p NTF3 0.709763558412506 1.11883921359361e-11 -0.668855124592218 0.000140030636687871 PITA;miRanda;miRNATAP -0.379489466442206 2.6461671900719e-05 NA NA NA hsa-miR-16-1-3p NTRK1 1.51429140700091 3.17219833254498e-37 -2.16917617916044 3.29741000934657e-22 mirMAP -0.547850527770562 3.2373436730389e-08 NA NA NA hsa-miR-185-3p NTRK1 0.993379985307475 2.62011454953707e-13 -2.16917617916044 3.29741000934657e-22 MirTarget -0.306701824990764 0.00125082909655452 NA NA NA hsa-miR-1271-5p NTRK2 0.900599702972936 3.07963385418853e-10 -2.73321393169747 3.3903895709546e-27 mirMAP -0.279489318800296 0.00692601449421045 NA NA NA hsa-miR-130b-3p NTRK2 1.12788913578446 2.939369462276e-16 -2.73321393169747 3.3903895709546e-27 mirMAP -0.726248428792849 1.06613529740873e-12 NA NA NA hsa-miR-130b-5p NTRK2 0.92990617673277 3.75880436852717e-12 -2.73321393169747 3.3903895709546e-27 mirMAP -0.664853909431365 5.97557240278784e-10 NA NA NA hsa-miR-140-3p NTRK2 0.989350547007025 6.14964028267239e-25 -2.73321393169747 3.3903895709546e-27 PITA -0.519386335791164 0.000414092080713394 NA NA NA hsa-miR-140-5p NTRK2 0.504309496243674 3.09884038729031e-11 -2.73321393169747 3.3903895709546e-27 miRanda -0.602681306142158 0.00214343631834989 NA NA NA hsa-miR-142-3p NTRK2 1.88928758773299 2.72985643829893e-22 -2.73321393169747 3.3903895709546e-27 miRanda -0.535926145944065 2.20805593228617e-14 NA NA NA hsa-miR-142-5p NTRK2 1.88417391525707 1.2096808039882e-27 -2.73321393169747 3.3903895709546e-27 mirMAP -0.630558350878623 2.91820135052768e-16 NA NA NA hsa-miR-146b-5p NTRK2 1.40714170253819 2.9559871816487e-12 -2.73321393169747 3.3903895709546e-27 PITA;miRanda -0.530011528937097 3.93751534627944e-14 NA NA NA hsa-miR-148a-5p NTRK2 0.415500302855613 0.000691460831436767 -2.73321393169747 3.3903895709546e-27 mirMAP -0.405140262998007 0.00102752820872671 NA NA NA hsa-miR-150-5p NTRK2 1.00371863159681 1.09871676395528e-09 -2.73321393169747 3.3903895709546e-27 mirMAP -0.350808561928945 8.73868933597758e-05 NA NA NA hsa-miR-155-5p NTRK2 3.26274490570809 5.06841441826518e-51 -2.73321393169747 3.3903895709546e-27 mirMAP -0.523772868638065 9.71166995832331e-21 NA NA NA hsa-miR-15b-3p NTRK2 1.49422666971434 5.44139893275088e-29 -2.73321393169747 3.3903895709546e-27 mirMAP -0.883103230853508 3.54431200556926e-19 NA NA NA hsa-miR-17-3p NTRK2 0.723795600017259 5.90151677164931e-18 -2.73321393169747 3.3903895709546e-27 miRNATAP -0.896939124509083 1.53151658135195e-07 NA NA NA hsa-miR-181a-5p NTRK2 1.11111114875339 3.97880443756442e-29 -2.73321393169747 3.3903895709546e-27 mirMAP -0.733342857770367 1.20516883867811e-07 NA NA NA hsa-miR-181b-5p NTRK2 1.49054296272357 3.69051660739368e-41 -2.73321393169747 3.3903895709546e-27 mirMAP -0.862482081682885 1.35863838260511e-13 NA NA NA hsa-miR-185-5p NTRK2 1.05056378692621 1.31174187880682e-22 -2.73321393169747 3.3903895709546e-27 mirMAP -0.903531978686805 2.07831492195628e-12 NA NA NA hsa-miR-186-5p NTRK2 0.507217561043443 9.04455748270995e-10 -2.73321393169747 3.3903895709546e-27 mirMAP -0.751111378776912 2.81517737650002e-05 NA NA NA hsa-miR-21-5p NTRK2 2.51462371613332 3.30620591950316e-66 -2.73321393169747 3.3903895709546e-27 mirMAP -0.866304204214476 4.74626449144815e-29 NA NA NA hsa-miR-22-3p NTRK2 0.198460552200729 0.00761005672059428 -2.73321393169747 3.3903895709546e-27 miRNATAP -0.940887284040991 4.26647718326073e-06 27662840 NTRK2 is an oncogene and associated with microRNA 22 regulation in human gastric cancer cell lines; The upstream regulator of NTRK2 microRNA-22 miR-22 was evaluated by dual-luciferase assay; In miR-22-upregulated MKN-28 and SNU-719 cells NTRK2 was further overexpressed to evaluate functional interaction between miR-22 and NTRK2 in GC; MiR-22 was verified to be an inverse upstream regulator of NTRK2; NTRK2 is an oncogene and reversely associated with miR-22 in regulating in vitro cancer development in GC gastric cancer hsa-miR-224-3p NTRK2 0.918780460857403 2.47005991706282e-07 -2.73321393169747 3.3903895709546e-27 mirMAP -0.296880246942849 0.000601419642883547 NA NA NA hsa-miR-28-3p NTRK2 1.01277915413238 1.8655970171461e-43 -2.73321393169747 3.3903895709546e-27 mirMAP -1.55284291020704 3.13155796248004e-19 NA NA NA hsa-miR-301a-3p NTRK2 0.259400847075798 0.0216890736701418 -2.73321393169747 3.3903895709546e-27 mirMAP -0.404742958628509 0.00266401330037096 NA NA NA hsa-miR-32-5p NTRK2 0.407826130035097 7.26884631998646e-06 -2.73321393169747 3.3903895709546e-27 mirMAP -0.598949064606831 0.000301224488907791 NA NA NA hsa-miR-330-5p NTRK2 1.44960468659754 2.12131210588035e-45 -2.73321393169747 3.3903895709546e-27 miRanda -0.967842612453671 5.88353202789705e-15 NA NA NA hsa-miR-339-5p NTRK2 0.322848334531193 0.0117281778821612 -2.73321393169747 3.3903895709546e-27 miRanda -0.535957387929389 5.05171729322507e-06 NA NA NA hsa-miR-340-5p NTRK2 1.14479851941741 2.91936881701444e-15 -2.73321393169747 3.3903895709546e-27 mirMAP -0.399071788262657 6.273974375913e-05 NA NA NA hsa-miR-342-3p NTRK2 1.4124432570595 1.07208971556131e-28 -2.73321393169747 3.3903895709546e-27 miRanda -0.756935028269671 9.6439214022446e-13 NA NA NA hsa-miR-374a-5p NTRK2 0.543061152108237 2.19403097299769e-14 -2.73321393169747 3.3903895709546e-27 mirMAP -0.782462980478737 0.000158244892407905 NA NA NA hsa-miR-452-3p NTRK2 1.72039996672257 1.35748079442153e-22 -2.73321393169747 3.3903895709546e-27 mirMAP -0.530028502444608 3.6645564067277e-11 NA NA NA hsa-miR-452-5p NTRK2 2.05325688842141 2.82238393643084e-40 -2.73321393169747 3.3903895709546e-27 mirMAP -0.627797662843897 5.64553003041051e-14 NA NA NA hsa-miR-454-3p NTRK2 0.68285296887698 1.17407812677787e-08 -2.73321393169747 3.3903895709546e-27 mirMAP -0.687524402930162 1.88953043418862e-08 NA NA NA hsa-miR-576-5p NTRK2 1.06681109513983 5.69294424466526e-24 -2.73321393169747 3.3903895709546e-27 PITA;mirMAP -0.776948309330999 3.45345465514776e-09 NA NA NA hsa-miR-590-3p NTRK2 1.13702599385212 3.53435739887793e-22 -2.73321393169747 3.3903895709546e-27 PITA;miRanda;mirMAP -1.00386450655333 3.56539151155473e-18 NA NA NA hsa-miR-590-5p NTRK2 0.709763558412506 1.11883921359361e-11 -2.73321393169747 3.3903895709546e-27 miRanda;mirMAP -0.969172844259923 1.50709586782717e-12 NA NA NA hsa-let-7e-5p OSMR -0.727009689927955 1.30690859412163e-11 1.36153455502477 3.985324426016e-22 miRNATAP -0.218701520979375 0.00363856962689776 NA NA NA hsa-let-7g-5p OSMR -0.739744008507763 1.07979566264383e-14 1.36153455502477 3.985324426016e-22 miRNATAP -0.268762490903486 0.00130291065633708 NA NA NA hsa-miR-125a-3p OSMR -0.372794471295036 0.000941729459601642 1.36153455502477 3.985324426016e-22 miRanda -0.272689553909526 0.000202745976836239 NA NA NA hsa-miR-139-5p OSMR -0.704802495091118 2.36904108453776e-06 1.36153455502477 3.985324426016e-22 miRanda -0.217612708084317 6.59776085677201e-05 NA NA NA hsa-miR-200b-3p OSMR -1.70383252137161 2.38979336321755e-30 1.36153455502477 3.985324426016e-22 TargetScan -0.326651139657421 3.98337753633749e-11 NA NA NA hsa-miR-335-5p OSMR -2.09515619961552 1.03765771499548e-25 1.36153455502477 3.985324426016e-22 miRNAWalker2_validate -0.127516808514079 0.000976141992860586 NA NA NA hsa-miR-362-3p OSMR -0.753214251798232 3.0025661608035e-07 1.36153455502477 3.985324426016e-22 miRanda -0.463582580033441 2.18081975759679e-17 NA NA NA hsa-miR-374b-5p OSMR 0.0804104684417872 0.365593963035077 1.36153455502477 3.985324426016e-22 mirMAP -0.28315007512758 0.00271123126499023 NA NA NA hsa-miR-429 OSMR -2.16569233119434 2.66862243626443e-37 1.36153455502477 3.985324426016e-22 miRanda;miRNATAP -0.340620538222573 2.82177945406616e-16 NA NA NA hsa-miR-590-3p PCK1 1.13702599385212 3.53435739887793e-22 -3.33934451701645 1.21953727565665e-18 miRanda -1.05484755959614 1.0863536025413e-09 NA NA NA hsa-miR-142-3p PCK2 1.88928758773299 2.72985643829893e-22 -1.47330176602593 1.0215145958622e-19 miRanda -0.174533882905998 0.000117007356233557 NA NA NA hsa-miR-16-5p PCK2 0.934012514027655 4.85417898318515e-24 -1.47330176602593 1.0215145958622e-19 miRNAWalker2_validate -0.346823683991268 0.000292572187767144 NA NA NA hsa-miR-326 PCK2 0.0283498662828876 0.83943976716391 -1.47330176602593 1.0215145958622e-19 miRanda -0.185108092259161 0.00660122108105388 NA NA NA hsa-miR-330-5p PCK2 1.44960468659754 2.12131210588035e-45 -1.47330176602593 1.0215145958622e-19 miRanda -0.577170663326394 1.18256740164928e-13 NA NA NA hsa-miR-335-3p PDGFA -1.36498175550207 6.84287752180534e-13 0.784073561233544 6.85051005668436e-15 mirMAP -0.123406397724081 2.37431234661371e-05 NA NA NA hsa-let-7g-5p PDGFB -0.739744008507763 1.07979566264383e-14 0.514864266712336 1.3417847330971e-06 miRNATAP -0.206195775236675 0.000576759591890832 NA NA NA hsa-miR-29a-3p PDGFB -0.431613225927952 4.10166815070288e-08 0.514864266712336 1.3417847330971e-06 MirTarget;miRNATAP -0.476936960397935 7.15396531394664e-11 NA NA NA hsa-miR-29b-3p PDGFB -0.228125979913806 0.0271621721891603 0.514864266712336 1.3417847330971e-06 MirTarget;miRNATAP -0.405612933369531 4.60127322330892e-13 NA NA NA hsa-miR-335-5p PDGFB -2.09515619961552 1.03765771499548e-25 0.514864266712336 1.3417847330971e-06 mirMAP -0.118392042230392 1.77239536755918e-05 NA NA NA hsa-miR-362-3p PDGFB -0.753214251798232 3.0025661608035e-07 0.514864266712336 1.3417847330971e-06 miRanda -0.149895887453564 0.000254386338042802 NA NA NA hsa-let-7f-1-3p PDGFC 0.477913872379336 4.46669616865068e-05 -0.0316307429734559 0.726012620173818 mirMAP -0.123030507985636 0.00696109914011498 NA NA NA hsa-miR-203a-3p PDGFD -2.25533513338731 1.77332845294014e-21 1.65004968079667 2.02041689804487e-26 MirTarget -0.156944311779093 1.58538197984785e-05 NA NA NA hsa-miR-335-3p PDGFD -1.36498175550207 6.84287752180534e-13 1.65004968079667 2.02041689804487e-26 mirMAP -0.362440852030351 1.06390246695021e-15 NA NA NA hsa-miR-381-3p PDGFD -0.674906433524392 0.000234722307243307 1.65004968079667 2.02041689804487e-26 MirTarget -0.202944737838563 5.58676073357791e-05 NA NA NA hsa-miR-495-3p PDGFD -0.742293735164333 7.11373308013543e-05 1.65004968079667 2.02041689804487e-26 mirMAP -0.215583875493114 1.87732298432318e-05 NA NA NA hsa-miR-9-5p PDGFD -2.23538606210968 1.28143998950751e-12 1.65004968079667 2.02041689804487e-26 MirTarget -0.20565646608886 5.5779942589556e-14 NA NA NA hsa-let-7b-5p PDGFRA 0.770868211539597 6.63408323707647e-21 -3.78993218513957 5.84256232656759e-33 miRNAWalker2_validate -0.744189949569241 0.000853482541380744 NA NA NA hsa-miR-106b-5p PDGFRA 1.07509411417907 2.11739194181878e-36 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -1.52699938391706 7.64844256452476e-15 NA NA NA hsa-miR-130b-3p PDGFRA 1.12788913578446 2.939369462276e-16 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -0.367163537880206 0.00634739389951908 NA NA NA hsa-miR-142-5p PDGFRA 1.88417391525707 1.2096808039882e-27 -3.78993218513957 5.84256232656759e-33 PITA;mirMAP;miRNATAP -0.473816152387234 3.28987725776332e-06 NA NA NA hsa-miR-16-1-3p PDGFRA 1.51429140700091 3.17219833254498e-37 -3.78993218513957 5.84256232656759e-33 MirTarget -0.936133152915647 8.28916380630762e-11 NA NA NA hsa-miR-17-5p PDGFRA 0.494260110870015 3.8348005261e-09 -3.78993218513957 5.84256232656759e-33 MirTarget;TargetScan;miRNATAP -1.12023059618189 6.47834222552057e-07 NA NA NA hsa-miR-181a-5p PDGFRA 1.11111114875339 3.97880443756442e-29 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -1.13167968181832 1.00578978735371e-10 NA NA NA hsa-miR-181b-5p PDGFRA 1.49054296272357 3.69051660739368e-41 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -1.0831393363512 3.58334758184159e-13 NA NA NA hsa-miR-186-5p PDGFRA 0.507217561043443 9.04455748270995e-10 -3.78993218513957 5.84256232656759e-33 MirTarget -0.76722366281197 0.00085346453663738 NA NA NA hsa-miR-193a-3p PDGFRA 0.849206638484406 3.68101781083335e-14 -3.78993218513957 5.84256232656759e-33 miRanda -0.670433703095133 5.33609287809933e-05 NA NA NA hsa-miR-196a-5p PDGFRA 0.440858887700369 2.0077143292463e-05 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -0.807966664131365 1.24871502376204e-05 NA NA NA hsa-miR-20a-5p PDGFRA 0.702602695798242 4.06372887613329e-13 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -1.0995133850917 7.76850607822403e-09 NA NA NA hsa-miR-224-5p PDGFRA 2.84654230414912 3.0480927226395e-47 -3.78993218513957 5.84256232656759e-33 MirTarget -0.560824939024689 9.29216493461181e-12 NA NA NA hsa-miR-27a-3p PDGFRA 0.558934437526245 1.44256383086177e-12 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -0.88742400202454 0.000202616724972923 NA NA NA hsa-miR-28-5p PDGFRA 0.461962042257226 3.32424690573327e-11 -3.78993218513957 5.84256232656759e-33 miRanda -0.92447717530526 0.000728496310352206 NA NA NA hsa-miR-330-5p PDGFRA 1.44960468659754 2.12131210588035e-45 -3.78993218513957 5.84256232656759e-33 miRanda -0.905908236362134 2.16923297258051e-08 NA NA NA hsa-miR-338-3p PDGFRA 0.906250377628867 2.76970900371139e-15 -3.78993218513957 5.84256232656759e-33 miRanda -0.637819265775912 7.72917116687921e-05 NA NA NA hsa-miR-338-5p PDGFRA 0.628429807914222 1.27575140717947e-06 -3.78993218513957 5.84256232656759e-33 mirMAP;miRNATAP -0.450795738987696 0.00269083695175716 NA NA NA hsa-miR-342-3p PDGFRA 1.4124432570595 1.07208971556131e-28 -3.78993218513957 5.84256232656759e-33 MirTarget;miRanda;miRNATAP -0.694461078438614 4.90067077355219e-07 NA NA NA hsa-miR-34a-5p PDGFRA 1.07544567720768 1.81510842038009e-20 -3.78993218513957 5.84256232656759e-33 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.873046587006104 1.72995840633287e-08 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-374a-5p PDGFRA 0.543061152108237 2.19403097299769e-14 -3.78993218513957 5.84256232656759e-33 mirMAP -0.874227666145286 0.000973487956615665 NA NA NA hsa-miR-454-3p PDGFRA 0.68285296887698 1.17407812677787e-08 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -0.564425512169116 0.00036544900032461 NA NA NA hsa-miR-455-5p PDGFRA 0.773674551205946 2.12957541541474e-09 -3.78993218513957 5.84256232656759e-33 MirTarget;PITA;miRanda -0.947080211002297 3.30515111107968e-11 NA NA NA hsa-miR-542-3p PDGFRA 0.431147917094433 0.000254981247606435 -3.78993218513957 5.84256232656759e-33 miRanda -0.442130370438674 0.00699356752210394 NA NA NA hsa-miR-576-5p PDGFRA 1.06681109513983 5.69294424466526e-24 -3.78993218513957 5.84256232656759e-33 mirMAP -1.09144002614137 6.09402828933535e-11 NA NA NA hsa-miR-590-3p PDGFRA 1.13702599385212 3.53435739887793e-22 -3.78993218513957 5.84256232656759e-33 miRanda;mirMAP -0.970020105353422 1.43465903827534e-10 NA NA NA hsa-miR-590-5p PDGFRA 0.709763558412506 1.11883921359361e-11 -3.78993218513957 5.84256232656759e-33 miRanda -0.805041348062301 6.78234301048255e-06 NA NA NA hsa-miR-616-5p PDGFRA 0.913426384742148 3.78418389333709e-09 -3.78993218513957 5.84256232656759e-33 mirMAP -0.558608482543338 5.68208963722558e-06 NA NA NA hsa-miR-7-1-3p PDGFRA 0.544601828025304 5.33830451326047e-07 -3.78993218513957 5.84256232656759e-33 mirMAP -0.741792492104915 2.27057862094563e-05 NA NA NA hsa-miR-93-5p PDGFRA 1.37365940377595 2.37567548683245e-46 -3.78993218513957 5.84256232656759e-33 MirTarget;miRNATAP -1.44923917304051 3.40005219888479e-18 NA NA NA hsa-miR-29a-3p PDGFRB -0.431613225927952 4.10166815070288e-08 0.733059789264273 9.08256836273142e-08 miRNATAP -0.452409180680295 2.53894645761997e-06 NA NA NA hsa-miR-29b-3p PDGFRB -0.228125979913806 0.0271621721891603 0.733059789264273 9.08256836273142e-08 miRNATAP -0.473479216745421 9.29300376624436e-11 NA NA NA hsa-miR-29c-3p PDGFRB -0.238671318446745 0.0141475322347596 0.733059789264273 9.08256836273142e-08 miRNATAP -0.358531848837518 5.48317704341144e-06 NA NA NA hsa-miR-664a-3p PDGFRB -0.019312777079624 0.825861598748857 0.733059789264273 9.08256836273142e-08 MirTarget -0.347941365487638 8.25629516369049e-05 NA NA NA hsa-miR-103a-3p PDPK1 0.779373475434461 7.37867196796994e-20 -0.510472322281575 1.42486443382158e-12 mirMAP -0.2175257694452 1.44786317870175e-06 NA NA NA hsa-miR-106b-5p PDPK1 1.07509411417907 2.11739194181878e-36 -0.510472322281575 1.42486443382158e-12 mirMAP -0.373775528284647 6.06427033576607e-20 NA NA NA hsa-miR-130b-5p PDPK1 0.92990617673277 3.75880436852717e-12 -0.510472322281575 1.42486443382158e-12 mirMAP -0.159801427785345 4.47085650105793e-08 NA NA NA hsa-miR-15a-5p PDPK1 1.42663930007845 1.36006952074963e-57 -0.510472322281575 1.42486443382158e-12 mirMAP -0.245722730963218 6.85341631070058e-11 NA NA NA hsa-miR-15b-5p PDPK1 0.773001494057531 1.71784656078957e-16 -0.510472322281575 1.42486443382158e-12 mirMAP -0.208820360940694 4.66456283570873e-07 NA NA NA hsa-miR-16-5p PDPK1 0.934012514027655 4.85417898318515e-24 -0.510472322281575 1.42486443382158e-12 mirMAP -0.178867552324022 1.44574835446988e-05 NA NA NA hsa-miR-17-5p PDPK1 0.494260110870015 3.8348005261e-09 -0.510472322281575 1.42486443382158e-12 miRNAWalker2_validate;mirMAP -0.188493522783968 8.61169959888075e-05 NA NA NA hsa-miR-185-5p PDPK1 1.05056378692621 1.31174187880682e-22 -0.510472322281575 1.42486443382158e-12 miRNAWalker2_validate -0.139764535618314 8.83463879935965e-05 NA NA NA hsa-miR-186-5p PDPK1 0.507217561043443 9.04455748270995e-10 -0.510472322281575 1.42486443382158e-12 mirMAP -0.182661949792262 0.000170813515132444 NA NA NA hsa-miR-195-5p PDPK1 0.346502644882604 0.0092562828415903 -0.510472322281575 1.42486443382158e-12 mirMAP -0.115115541560453 0.000175169862056641 NA NA NA hsa-miR-197-3p PDPK1 0.297760714271229 0.00102679606305048 -0.510472322281575 1.42486443382158e-12 mirMAP -0.151013671003568 0.000855286791616651 NA NA NA hsa-miR-20a-5p PDPK1 0.702602695798242 4.06372887613329e-13 -0.510472322281575 1.42486443382158e-12 mirMAP -0.152645012433526 0.000191506454719393 NA NA NA hsa-miR-22-5p PDPK1 -0.197038086012602 0.106234828461117 -0.510472322281575 1.42486443382158e-12 miRNATAP -0.109207513326609 0.00120206518580051 NA NA NA hsa-miR-2355-5p PDPK1 1.57515081110162 3.54962327490702e-48 -0.510472322281575 1.42486443382158e-12 mirMAP -0.172045618576272 9.87605041174559e-08 NA NA NA hsa-miR-24-3p PDPK1 0.173813044685099 0.00565259443420961 -0.510472322281575 1.42486443382158e-12 miRNAWalker2_validate -0.488231684917234 2.64170172150227e-14 NA NA NA hsa-miR-27a-3p PDPK1 0.558934437526245 1.44256383086177e-12 -0.510472322281575 1.42486443382158e-12 miRNATAP -0.354049703707722 5.69100253886832e-13 NA NA NA hsa-miR-28-5p PDPK1 0.461962042257226 3.32424690573327e-11 -0.510472322281575 1.42486443382158e-12 mirMAP -0.306922928697709 7.92063821346507e-08 NA NA NA hsa-miR-320a PDPK1 0.412740558379182 2.02929519701706e-05 -0.510472322281575 1.42486443382158e-12 miRanda -0.196344112191884 2.57519561738161e-06 NA NA NA hsa-miR-320b PDPK1 0.300497419754843 0.0245219177384172 -0.510472322281575 1.42486443382158e-12 miRanda -0.140727534920885 3.77176273785697e-06 NA NA NA hsa-miR-330-3p PDPK1 0.912906550436308 3.35037014057665e-13 -0.510472322281575 1.42486443382158e-12 mirMAP -0.160262123414231 5.00464356133853e-07 NA NA NA hsa-miR-330-5p PDPK1 1.44960468659754 2.12131210588035e-45 -0.510472322281575 1.42486443382158e-12 mirMAP -0.236462612335887 2.67486358986537e-12 NA NA NA hsa-miR-342-3p PDPK1 1.4124432570595 1.07208971556131e-28 -0.510472322281575 1.42486443382158e-12 mirMAP -0.194551040391011 1.38426500608919e-11 NA NA NA hsa-miR-374a-3p PDPK1 1.13863935833993 2.79089304015401e-44 -0.510472322281575 1.42486443382158e-12 mirMAP -0.183366708748884 2.89759767613272e-05 NA NA NA hsa-miR-423-5p PDPK1 0.250929012519631 0.00288495915028486 -0.510472322281575 1.42486443382158e-12 miRNAWalker2_validate -0.184849862683297 0.000153104377010708 NA NA NA hsa-miR-484 PDPK1 0.571987778099603 9.67278224458421e-10 -0.510472322281575 1.42486443382158e-12 mirMAP -0.182086606148251 2.06174614498475e-05 NA NA NA hsa-miR-497-5p PDPK1 0.227757383708836 0.0600073987853074 -0.510472322281575 1.42486443382158e-12 mirMAP -0.101451111078774 0.00283638206539402 NA NA NA hsa-miR-590-3p PDPK1 1.13702599385212 3.53435739887793e-22 -0.510472322281575 1.42486443382158e-12 miRanda;miRNATAP -0.180543665890065 2.20548520230667e-08 NA NA NA hsa-miR-590-5p PDPK1 0.709763558412506 1.11883921359361e-11 -0.510472322281575 1.42486443382158e-12 miRanda -0.198011019013869 1.45790485472605e-07 NA NA NA hsa-miR-93-5p PDPK1 1.37365940377595 2.37567548683245e-46 -0.510472322281575 1.42486443382158e-12 mirMAP -0.21235032268781 5.41769778680355e-09 NA NA NA hsa-miR-149-5p PGF -1.95790336710741 8.46371715052367e-27 3.69738936393984 3.63417715211415e-41 miRNATAP -0.434144787619864 4.54062927450752e-07 NA NA NA hsa-miR-199b-5p PGF -2.39483476763681 1.04659509514884e-17 3.69738936393984 3.63417715211415e-41 miRanda -0.224137431584973 0.000173766273357621 NA NA NA hsa-miR-335-5p PGF -2.09515619961552 1.03765771499548e-25 3.69738936393984 3.63417715211415e-41 miRNATAP -0.515140827192959 5.43702586061577e-11 NA NA NA hsa-miR-429 PGF -2.16569233119434 2.66862243626443e-37 3.69738936393984 3.63417715211415e-41 miRNATAP -0.773105088772864 1.94034273033144e-19 NA NA NA hsa-miR-766-3p PGF -0.230617949950715 0.0566289375252083 3.69738936393984 3.63417715211415e-41 MirTarget -0.376787325836558 0.00862438364612218 NA NA NA hsa-miR-1307-3p PHLPP1 0.261776262040232 0.00360403340784407 -0.756967469809353 3.23520037750824e-19 miRNAWalker2_validate -0.178702406875637 0.00114380650018176 NA NA NA hsa-miR-16-2-3p PHLPP1 1.3046118743965 4.17207934608428e-19 -0.756967469809353 3.23520037750824e-19 MirTarget -0.189844162541638 1.14861347628888e-09 NA NA NA hsa-miR-224-5p PHLPP1 2.84654230414912 3.0480927226395e-47 -0.756967469809353 3.23520037750824e-19 MirTarget -0.145216091606342 3.45010496993508e-12 23846336;26245343 microRNA 224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2;miR-224 expression was associated with advanced clinical TNM stage pathologic grade and the level of PHLPP1 and PHLPP2 proteins in ESCC tissues; miR-224 was able to bind to the 3' untranslated region 3'-UTR of PHLPP1 and PHLPP2 mRNA to suppress their expression; The current study demonstrated that miR-224 acts as an oncogenic miRNA in ESCC possibly by targeting PHLPP1 and PHLPP2 ;staging colorectal cancer;esophageal cancer hsa-miR-330-5p PHLPP1 1.44960468659754 2.12131210588035e-45 -0.756967469809353 3.23520037750824e-19 miRanda -0.350817156873612 9.75184938992967e-19 NA NA NA hsa-miR-331-3p PHLPP1 0.431607034018882 6.83022920590941e-05 -0.756967469809353 3.23520037750824e-19 miRNAWalker2_validate;MirTarget;miRNATAP -0.189265205244878 2.50247905532916e-05 NA NA NA hsa-miR-452-5p PHLPP1 2.05325688842141 2.82238393643084e-40 -0.756967469809353 3.23520037750824e-19 MirTarget;miRNATAP -0.196691898519544 4.51461180621192e-13 NA NA NA hsa-miR-484 PHLPP1 0.571987778099603 9.67278224458421e-10 -0.756967469809353 3.23520037750824e-19 miRNAWalker2_validate -0.256625451948361 4.94013117139571e-07 NA NA NA hsa-miR-589-5p PHLPP1 0.696241532021631 5.26958362886071e-16 -0.756967469809353 3.23520037750824e-19 MirTarget -0.329669888378605 1.03270705563614e-09 NA NA NA hsa-miR-590-3p PHLPP1 1.13702599385212 3.53435739887793e-22 -0.756967469809353 3.23520037750824e-19 miRanda -0.26575672622697 3.58751398698127e-12 NA NA NA hsa-miR-7-1-3p PHLPP1 0.544601828025304 5.33830451326047e-07 -0.756967469809353 3.23520037750824e-19 MirTarget -0.118730570782618 0.00812859191975646 NA NA NA hsa-miR-106b-5p PHLPP2 1.07509411417907 2.11739194181878e-36 -0.312124889062853 0.000107676841306616 miRNATAP -0.171538786864869 0.000259482829449077 NA NA NA hsa-miR-126-5p PHLPP2 0.785607261431085 5.77058629454465e-13 -0.312124889062853 0.000107676841306616 mirMAP -0.122156161517383 0.0020846244674317 NA NA NA hsa-miR-195-5p PHLPP2 0.346502644882604 0.0092562828415903 -0.312124889062853 0.000107676841306616 MirTarget;miRNATAP -0.159990262039885 1.43358429755245e-06 NA NA NA hsa-miR-26b-5p PHLPP2 -0.251437253429904 0.00270935785098697 -0.312124889062853 0.000107676841306616 miRNAWalker2_validate -0.158140410531752 0.00321046229686858 NA NA NA hsa-miR-27a-3p PHLPP2 0.558934437526245 1.44256383086177e-12 -0.312124889062853 0.000107676841306616 MirTarget;miRNATAP -0.364761024902945 1.15845980559794e-11 NA NA NA hsa-miR-330-5p PHLPP2 1.44960468659754 2.12131210588035e-45 -0.312124889062853 0.000107676841306616 miRanda -0.117153211030176 0.0020262632269336 NA NA NA hsa-miR-497-5p PHLPP2 0.227757383708836 0.0600073987853074 -0.312124889062853 0.000107676841306616 MirTarget;miRNATAP -0.15005959956838 4.57413635197486e-05 NA NA NA hsa-miR-92b-3p PHLPP2 0.418630595140165 6.50466149211154e-05 -0.312124889062853 0.000107676841306616 MirTarget;miRNATAP -0.187349197453898 8.65476186449822e-06 NA NA NA hsa-miR-139-5p PIK3AP1 -0.704802495091118 2.36904108453776e-06 0.457293038074403 0.00205644801227075 miRanda -0.172809303229768 0.00143579352374058 NA NA NA hsa-let-7f-1-3p PIK3CA 0.477913872379336 4.46669616865068e-05 -0.342309377518198 0.000115361959187206 mirMAP -0.117169302105272 0.00980511224865979 NA NA NA hsa-miR-148a-5p PIK3CA 0.415500302855613 0.000691460831436767 -0.342309377518198 0.000115361959187206 mirMAP -0.127137756769153 0.00150846590255829 NA NA NA hsa-miR-320b PIK3CA 0.300497419754843 0.0245219177384172 -0.342309377518198 0.000115361959187206 miRanda -0.109684919459557 0.00295331979925903 NA NA NA hsa-miR-339-5p PIK3CA 0.322848334531193 0.0117281778821612 -0.342309377518198 0.000115361959187206 miRanda -0.156390103299638 4.31357238138231e-05 NA NA NA hsa-miR-590-3p PIK3CA 1.13702599385212 3.53435739887793e-22 -0.342309377518198 0.000115361959187206 miRanda;mirMAP -0.167970910292111 1.76355187639927e-05 NA NA NA hsa-miR-590-5p PIK3CA 0.709763558412506 1.11883921359361e-11 -0.342309377518198 0.000115361959187206 miRanda -0.179027916238388 8.77558290901021e-05 NA NA NA hsa-miR-130b-3p PIK3CB 1.12788913578446 2.939369462276e-16 -0.247995112719303 0.00148503458375338 miRNATAP -0.166034631736904 1.58184303321712e-08 NA NA NA hsa-miR-19a-3p PIK3CB 0.722913586880779 2.76301458932381e-10 -0.247995112719303 0.00148503458375338 miRNATAP -0.138948641019506 0.000146950619817948 NA NA NA hsa-miR-19b-3p PIK3CB 0.195940928879427 0.0300512922542325 -0.247995112719303 0.00148503458375338 miRNATAP -0.155249167038679 0.00123255333914152 NA NA NA hsa-miR-25-3p PIK3CB 1.12016166564779 3.79069348635778e-48 -0.247995112719303 0.00148503458375338 miRNATAP -0.168848015389201 0.000511445370430535 NA NA NA hsa-miR-590-3p PIK3CB 1.13702599385212 3.53435739887793e-22 -0.247995112719303 0.00148503458375338 miRNATAP -0.152204162601648 8.6055969781532e-06 NA NA NA hsa-miR-92b-3p PIK3CB 0.418630595140165 6.50466149211154e-05 -0.247995112719303 0.00148503458375338 miRNATAP -0.132204554754912 0.00123182058684873 NA NA NA hsa-miR-10b-5p PIK3CD -0.89971464210447 1.18190532299934e-20 0.827862115800704 6.93199253004924e-19 miRNAWalker2_validate -0.322882758324939 5.32986923354336e-10 NA NA NA hsa-miR-1468-5p PIK3CD -0.311126383179539 0.00979113361106863 0.827862115800704 6.93199253004924e-19 MirTarget -0.200155097962759 8.08016260976088e-06 NA NA NA hsa-miR-30a-5p PIK3CD -0.778411951775343 2.73322451127932e-16 0.827862115800704 6.93199253004924e-19 miRNAWalker2_validate;MirTarget;miRNATAP -0.206007694378125 0.000161176631172019 23486085 miR 30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma; A luciferase reporter assay was performed to determine target association between miR-30a and phosphoinositide 3-kinase catalytic subunit delta PIK3CD miR-30a was significantly downregulated in highly metastatic CRC cell lines and metastatic tissues; Further studies revealed that PIK3CD is a direct target of miR-30a as miR-30a bounds directly to the 3'-UTR of PIK3CD subsequently reducing its expression; Similar to the restoring miR-30a expression PIK3CD downregulation inhibited cell migration and invasion whereas PIK3CD overexpression rescued the suppressive effect of miR-30a; Moreover significant downregulation of miR-30a in metastatic CRC tissues was found to be inversely correlated with PIK3CD expression; Mechanistic studies revealed that miR-30a down-regulated the expression of key components of the Akt/mTOR pathway whereas PIK3CD overexpression reversed this negative effect cell migration colorectal cancer hsa-miR-30b-3p PIK3CD -1.64703050862226 1.89878531036464e-31 0.827862115800704 6.93199253004924e-19 MirTarget -0.256459682857462 3.84122966933957e-14 NA NA NA hsa-miR-30b-5p PIK3CD -1.18330589477119 6.8341618466966e-27 0.827862115800704 6.93199253004924e-19 MirTarget -0.212463225121162 2.43792629370427e-06 NA NA NA hsa-miR-30c-5p PIK3CD -1.08783070774238 2.02505402525786e-24 0.827862115800704 6.93199253004924e-19 MirTarget;miRNATAP -0.191697315876392 4.85249073283528e-05 NA NA NA hsa-miR-30d-5p PIK3CD -0.202727675788184 0.00659067084745794 0.827862115800704 6.93199253004924e-19 MirTarget;miRNATAP -0.209303428523125 0.00450077920142443 NA NA NA hsa-miR-106b-5p PIK3R1 1.07509411417907 2.11739194181878e-36 -0.234314125271815 0.0111750886765385 MirTarget;miRNATAP -0.179369079303185 0.000816789511004284 NA NA NA hsa-miR-221-3p PIK3R1 0.337895669520713 0.0136448974691037 -0.234314125271815 0.0111750886765385 MirTarget -0.163462882563838 9.21701112965761e-06 NA NA NA hsa-miR-222-3p PIK3R1 0.214811008033524 0.0965295551752457 -0.234314125271815 0.0111750886765385 MirTarget -0.107248741245045 0.00671314109485487 NA NA NA hsa-miR-590-3p PIK3R1 1.13702599385212 3.53435739887793e-22 -0.234314125271815 0.0111750886765385 miRanda;mirMAP -0.106905404095112 0.00880343764678398 NA NA NA hsa-miR-182-5p PIK3R3 -0.608710746044567 0.0025264935278104 0.439819702071113 8.25824839758606e-05 mirMAP -0.153374534942348 3.96734579923425e-07 NA NA NA hsa-miR-339-5p PIK3R3 0.322848334531193 0.0117281778821612 0.439819702071113 8.25824839758606e-05 MirTarget;miRanda -0.192609585710903 6.48743953207512e-05 NA NA NA hsa-miR-365a-3p PIK3R3 0.80809616164259 2.36039522526e-12 0.439819702071113 8.25824839758606e-05 MirTarget -0.16533292375838 0.00153486106521956 NA NA NA hsa-miR-96-5p PIK3R3 -1.00223771166604 3.91564621567028e-06 0.439819702071113 8.25824839758606e-05 mirMAP -0.164731670984697 7.78245878052581e-09 NA NA NA hsa-miR-125a-3p PIK3R5 -0.372794471295036 0.000941729459601642 3.18542758418586 6.04695754116875e-70 miRanda -0.407465916624748 0.000192324867439568 NA NA NA hsa-miR-125a-5p PIK3R5 -0.561874059994802 7.3931856356891e-13 3.18542758418586 6.04695754116875e-70 MirTarget;miRanda -1.34358622921882 2.31129700790236e-20 NA NA NA hsa-miR-125b-5p PIK3R5 -0.825456421494266 2.13029877878434e-15 3.18542758418586 6.04695754116875e-70 MirTarget -0.67295054872876 1.75325492827967e-09 NA NA NA hsa-miR-615-3p PIK3R5 -0.777370544471479 2.08193713560545e-08 3.18542758418586 6.04695754116875e-70 miRanda -0.258205105771951 0.00312779262258178 NA NA NA hsa-miR-127-5p PIK3R6 -1.33574359249785 5.73079880594981e-13 3.59793599756853 4.49202150176962e-61 MirTarget -0.284954274220405 0.000159135115849514 NA NA NA hsa-miR-149-5p PIK3R6 -1.95790336710741 8.46371715052367e-27 3.59793599756853 4.49202150176962e-61 MirTarget -0.5160774612613 4.01222398243273e-13 NA NA NA hsa-miR-30c-2-3p PIK3R6 -1.28402709024345 6.77577627955178e-25 3.59793599756853 4.49202150176962e-61 MirTarget -1.05163641586424 1.70867214539916e-25 NA NA NA hsa-let-7a-3p PKN2 0.0677487960013088 0.460458477653989 -0.211166775189587 0.000330878792609084 miRNATAP -0.128668937454516 0.000305924673426719 NA NA NA hsa-let-7i-5p PKN2 0.911372377723717 7.11483853341932e-31 -0.211166775189587 0.000330878792609084 miRNATAP -0.101345534113043 0.00738615075987351 NA NA NA hsa-miR-106b-5p PKN2 1.07509411417907 2.11739194181878e-36 -0.211166775189587 0.000330878792609084 MirTarget;miRNATAP -0.193323548277615 8.77039336061963e-09 NA NA NA hsa-miR-223-3p PKN2 1.23291409735619 1.07767240442694e-17 -0.211166775189587 0.000330878792609084 MirTarget -0.109947460636572 1.96801683762243e-07 NA NA NA hsa-miR-27a-3p PKN2 0.558934437526245 1.44256383086177e-12 -0.211166775189587 0.000330878792609084 miRNATAP -0.217615314398375 3.66008688904728e-08 NA NA NA hsa-miR-589-5p PKN2 0.696241532021631 5.26958362886071e-16 -0.211166775189587 0.000330878792609084 MirTarget -0.174661297164384 1.22060416742878e-06 NA NA NA hsa-miR-590-5p PKN2 0.709763558412506 1.11883921359361e-11 -0.211166775189587 0.000330878792609084 miRanda -0.104734973585419 0.000516452708673769 NA NA NA hsa-miR-193b-3p PKN3 -0.273325765316079 0.104328826585392 0.631328505653637 1.05854232776644e-08 miRNAWalker2_validate -0.199193451074255 4.26908593943272e-08 NA NA NA hsa-miR-324-3p PKN3 -0.197662887871899 0.0298845059559819 0.631328505653637 1.05854232776644e-08 miRNAWalker2_validate -0.312773353202916 4.63393929040071e-06 NA NA NA hsa-miR-17-3p PPP2CA 0.723795600017259 5.90151677164931e-18 -0.0986621185828058 0.0322311495916405 MirTarget -0.115609136292778 5.1945828551556e-05 NA NA NA hsa-miR-590-3p PPP2CB 1.13702599385212 3.53435739887793e-22 -0.487343407097616 6.12363210381507e-16 miRanda -0.148108586350573 5.65176554878302e-08 NA NA NA hsa-miR-146b-5p PPP2R1B 1.40714170253819 2.9559871816487e-12 -0.454734829935764 5.04192101717804e-14 miRanda -0.106167714667314 4.04187575982608e-11 NA NA NA hsa-miR-15a-5p PPP2R1B 1.42663930007845 1.36006952074963e-57 -0.454734829935764 5.04192101717804e-14 MirTarget -0.158870694074697 7.39147854946692e-07 NA NA NA hsa-miR-15b-5p PPP2R1B 0.773001494057531 1.71784656078957e-16 -0.454734829935764 5.04192101717804e-14 MirTarget -0.155184743390608 9.11437716247661e-06 NA NA NA hsa-miR-16-5p PPP2R1B 0.934012514027655 4.85417898318515e-24 -0.454734829935764 5.04192101717804e-14 miRNAWalker2_validate;MirTarget -0.157201852909443 5.57771892550489e-06 NA NA NA hsa-miR-186-5p PPP2R1B 0.507217561043443 9.04455748270995e-10 -0.454734829935764 5.04192101717804e-14 mirMAP -0.144865494129061 0.000395809025710765 NA NA NA hsa-miR-195-5p PPP2R1B 0.346502644882604 0.0092562828415903 -0.454734829935764 5.04192101717804e-14 MirTarget -0.11856735020381 3.74905556486083e-06 NA NA NA hsa-miR-320a PPP2R1B 0.412740558379182 2.02929519701706e-05 -0.454734829935764 5.04192101717804e-14 miRanda -0.150930956528645 1.79572706330847e-05 NA NA NA hsa-miR-330-5p PPP2R1B 1.44960468659754 2.12131210588035e-45 -0.454734829935764 5.04192101717804e-14 miRanda -0.167386992703103 5.71928058591198e-09 NA NA NA hsa-miR-452-5p PPP2R1B 2.05325688842141 2.82238393643084e-40 -0.454734829935764 5.04192101717804e-14 MirTarget -0.116940593190983 1.2480959791507e-09 NA NA NA hsa-miR-497-5p PPP2R1B 0.227757383708836 0.0600073987853074 -0.454734829935764 5.04192101717804e-14 MirTarget -0.132380804791297 2.85132271643844e-06 NA NA NA hsa-miR-576-5p PPP2R1B 1.06681109513983 5.69294424466526e-24 -0.454734829935764 5.04192101717804e-14 mirMAP -0.107694240077987 0.00039255398459087 NA NA NA hsa-miR-590-3p PPP2R1B 1.13702599385212 3.53435739887793e-22 -0.454734829935764 5.04192101717804e-14 MirTarget;miRanda;mirMAP -0.11445817178589 2.96165176993764e-05 NA NA NA hsa-miR-126-5p PPP2R2B 0.785607261431085 5.77058629454465e-13 -2.59071496355859 1.80864868504118e-46 MirTarget -0.456787294756938 7.12757128741115e-06 NA NA NA hsa-miR-486-5p PPP2R2B 1.16748143760361 1.68410465883829e-08 -2.59071496355859 1.80864868504118e-46 miRanda -0.230822671160867 2.04976602859073e-05 NA NA NA hsa-miR-181a-2-3p PPP2R2C 0.549613348249471 1.48987286432989e-10 0.204865561537737 0.512618305427393 MirTarget -0.726569332821327 0.00021238285944272 NA NA NA hsa-miR-502-3p PPP2R2C -1.10416310320528 1.55354569985732e-22 0.204865561537737 0.512618305427393 MirTarget;PITA;miRNATAP -0.5596435835033 8.09961906626845e-05 NA NA NA hsa-miR-106b-5p PPP2R3A 1.07509411417907 2.11739194181878e-36 -0.779066092101417 3.6099532872185e-13 mirMAP -0.475118465589407 2.18767260623296e-14 NA NA NA hsa-miR-140-5p PPP2R3A 0.504309496243674 3.09884038729031e-11 -0.779066092101417 3.6099532872185e-13 PITA;miRanda;miRNATAP -0.228820988374505 0.00390388512779031 NA NA NA hsa-miR-143-3p PPP2R3A 0.544259011512089 1.71102635165867e-05 -0.779066092101417 3.6099532872185e-13 miRNATAP -0.182114860175541 0.000137251939631987 NA NA NA hsa-miR-17-5p PPP2R3A 0.494260110870015 3.8348005261e-09 -0.779066092101417 3.6099532872185e-13 mirMAP -0.269586291137143 0.000171529659989663 NA NA NA hsa-miR-181a-5p PPP2R3A 1.11111114875339 3.97880443756442e-29 -0.779066092101417 3.6099532872185e-13 MirTarget -0.321959164402381 7.3636140047247e-09 NA NA NA hsa-miR-181b-5p PPP2R3A 1.49054296272357 3.69051660739368e-41 -0.779066092101417 3.6099532872185e-13 MirTarget -0.269266101457998 1.83837934521402e-08 NA NA NA hsa-miR-181c-5p PPP2R3A 0.762784646696248 4.48373118147729e-10 -0.779066092101417 3.6099532872185e-13 MirTarget -0.16048760153898 0.00101333315474537 NA NA NA hsa-miR-181d-5p PPP2R3A 1.00720380524132 6.04219503683814e-14 -0.779066092101417 3.6099532872185e-13 MirTarget -0.174575165647884 6.51408786685023e-05 NA NA NA hsa-miR-20a-5p PPP2R3A 0.702602695798242 4.06372887613329e-13 -0.779066092101417 3.6099532872185e-13 mirMAP -0.290821010148195 1.64584393263335e-06 NA NA NA hsa-miR-320a PPP2R3A 0.412740558379182 2.02929519701706e-05 -0.779066092101417 3.6099532872185e-13 miRanda -0.211848351568103 0.000751547580435052 NA NA NA hsa-miR-320b PPP2R3A 0.300497419754843 0.0245219177384172 -0.779066092101417 3.6099532872185e-13 miRanda -0.165134331891285 0.000305499630397394 NA NA NA hsa-miR-576-5p PPP2R3A 1.06681109513983 5.69294424466526e-24 -0.779066092101417 3.6099532872185e-13 PITA;mirMAP -0.228114032999107 2.19491830905359e-05 NA NA NA hsa-miR-589-5p PPP2R3A 0.696241532021631 5.26958362886071e-16 -0.779066092101417 3.6099532872185e-13 MirTarget -0.229997121028405 0.000792662160689723 NA NA NA hsa-miR-590-3p PPP2R3A 1.13702599385212 3.53435739887793e-22 -0.779066092101417 3.6099532872185e-13 MirTarget;PITA;miRanda -0.258198220653613 8.88826589322506e-08 NA NA NA hsa-miR-93-5p PPP2R3A 1.37365940377595 2.37567548683245e-46 -0.779066092101417 3.6099532872185e-13 mirMAP -0.293936110116899 7.13003657540189e-08 NA NA NA hsa-miR-107 PPP2R5A 0.140046250553248 0.0943611632552367 -0.643260112244032 1.19448793398462e-23 miRanda -0.231984993904772 2.77426347732745e-07 NA NA NA hsa-miR-1270 PPP2R5A 1.71697026896618 1.75919401373445e-16 -0.643260112244032 1.19448793398462e-23 PITA -0.108411888808129 1.55082077643523e-10 NA NA NA hsa-miR-197-3p PPP2R5A 0.297760714271229 0.00102679606305048 -0.643260112244032 1.19448793398462e-23 MirTarget -0.228728341471082 2.81026889555884e-08 NA NA NA hsa-miR-338-5p PPP2R5A 0.628429807914222 1.27575140717947e-06 -0.643260112244032 1.19448793398462e-23 MirTarget;PITA;miRNATAP -0.112112043091588 0.000125681253522379 NA NA NA hsa-miR-34a-5p PPP2R5A 1.07544567720768 1.81510842038009e-20 -0.643260112244032 1.19448793398462e-23 MirTarget;miRNATAP -0.195614443431858 7.33832868103353e-11 NA NA NA hsa-miR-455-5p PPP2R5A 0.773674551205946 2.12957541541474e-09 -0.643260112244032 1.19448793398462e-23 miRanda -0.274481257130099 7.27133740241979e-25 NA NA NA hsa-miR-484 PPP2R5A 0.571987778099603 9.67278224458421e-10 -0.643260112244032 1.19448793398462e-23 miRNAWalker2_validate -0.242719264343379 4.20537162281745e-10 NA NA NA hsa-miR-590-3p PPP2R5A 1.13702599385212 3.53435739887793e-22 -0.643260112244032 1.19448793398462e-23 miRNAWalker2_validate -0.198606455287551 1.60759444974742e-11 NA NA NA hsa-miR-15a-5p PPP2R5C 1.42663930007845 1.36006952074963e-57 -0.310564619725865 1.06102495468945e-11 miRNATAP -0.141061635081439 3.02504267033446e-09 NA NA NA hsa-miR-15b-5p PPP2R5C 0.773001494057531 1.71784656078957e-16 -0.310564619725865 1.06102495468945e-11 miRNATAP -0.148937407861973 8.54026373815838e-09 NA NA NA hsa-miR-16-5p PPP2R5C 0.934012514027655 4.85417898318515e-24 -0.310564619725865 1.06102495468945e-11 miRNAWalker2_validate;miRNATAP -0.126911598501026 8.65262570174567e-07 NA NA NA hsa-miR-186-5p PPP2R5C 0.507217561043443 9.04455748270995e-10 -0.310564619725865 1.06102495468945e-11 mirMAP;miRNATAP -0.114342123059645 0.00017947862593708 NA NA NA hsa-miR-193a-3p PPP2R5C 0.849206638484406 3.68101781083335e-14 -0.310564619725865 1.06102495468945e-11 PITA;miRanda;miRNATAP -0.124782283187022 1.02036760294786e-08 NA NA NA hsa-miR-28-3p PPP2R5C 1.01277915413238 1.8655970171461e-43 -0.310564619725865 1.06102495468945e-11 PITA -0.191969270641742 2.36352576421493e-10 NA NA NA hsa-miR-455-5p PPP2R5C 0.773674551205946 2.12957541541474e-09 -0.310564619725865 1.06102495468945e-11 miRanda -0.108446370508491 1.51254254916574e-08 NA NA NA hsa-let-7a-3p PPP2R5E 0.0677487960013088 0.460458477653989 -0.544089570321744 5.01720071232967e-12 mirMAP -0.14378874755493 0.0035624757595797 NA NA NA hsa-miR-130b-3p PPP2R5E 1.12788913578446 2.939369462276e-16 -0.544089570321744 5.01720071232967e-12 mirMAP -0.136050970638676 1.00710403158397e-05 NA NA NA hsa-miR-16-2-3p PPP2R5E 1.3046118743965 4.17207934608428e-19 -0.544089570321744 5.01720071232967e-12 mirMAP -0.110084678266901 0.000137054684628662 NA NA NA hsa-miR-181a-5p PPP2R5E 1.11111114875339 3.97880443756442e-29 -0.544089570321744 5.01720071232967e-12 MirTarget;mirMAP -0.212554818637739 2.0467778649869e-07 NA NA NA hsa-miR-181b-5p PPP2R5E 1.49054296272357 3.69051660739368e-41 -0.544089570321744 5.01720071232967e-12 MirTarget;mirMAP -0.224267051383363 1.06337675354213e-10 NA NA NA hsa-miR-19a-3p PPP2R5E 0.722913586880779 2.76301458932381e-10 -0.544089570321744 5.01720071232967e-12 MirTarget -0.12207156145816 0.00137627997426489 NA NA NA hsa-miR-19b-3p PPP2R5E 0.195940928879427 0.0300512922542325 -0.544089570321744 5.01720071232967e-12 miRTarBase;MirTarget -0.156314478032495 0.00174984372588633 NA NA NA hsa-miR-23a-3p PPP2R5E 0.761438723382355 4.09310879199257e-27 -0.544089570321744 5.01720071232967e-12 MirTarget -0.273723372973 2.97454423201905e-06 24997345 Downregulation of PPP2R5E expression by miR 23a suppresses apoptosis to facilitate the growth of gastric cancer cells; Here we declare that PPP2R5E is downregulated by miR-23a and induces cell growth inhibition and apoptosis in gastric cancer cells; PPP2R5E is identified as a new target of miR-23a; Moreover overexpression of PPP2R5E reversed the negative effects of miR-23a; We highlight the significance of miR-23a and PPP2R5E in the proliferation and apoptosis of gastric cancer cells gastric cancer hsa-miR-330-5p PPP2R5E 1.44960468659754 2.12131210588035e-45 -0.544089570321744 5.01720071232967e-12 miRanda -0.13912757041665 0.000243786785499114 NA NA NA hsa-miR-342-3p PPP2R5E 1.4124432570595 1.07208971556131e-28 -0.544089570321744 5.01720071232967e-12 miRanda -0.116005646717339 0.000317225910037246 NA NA NA hsa-miR-365a-3p PPP2R5E 0.80809616164259 2.36039522526e-12 -0.544089570321744 5.01720071232967e-12 miRNAWalker2_validate -0.216509219959858 4.68542600488872e-09 NA NA NA hsa-miR-374a-3p PPP2R5E 1.13863935833993 2.79089304015401e-44 -0.544089570321744 5.01720071232967e-12 MirTarget -0.237358886571338 6.18027184651909e-07 NA NA NA hsa-miR-455-5p PPP2R5E 0.773674551205946 2.12957541541474e-09 -0.544089570321744 5.01720071232967e-12 miRanda -0.196435386840447 3.41583355965528e-09 NA NA NA hsa-miR-542-3p PPP2R5E 0.431147917094433 0.000254981247606435 -0.544089570321744 5.01720071232967e-12 miRanda -0.109255011480076 0.00390671074201949 NA NA NA hsa-miR-590-3p PPP2R5E 1.13702599385212 3.53435739887793e-22 -0.544089570321744 5.01720071232967e-12 MirTarget;PITA;miRanda;mirMAP -0.146818389290623 3.75489241809668e-05 NA NA NA hsa-miR-590-5p PPP2R5E 0.709763558412506 1.11883921359361e-11 -0.544089570321744 5.01720071232967e-12 miRanda -0.124058531639696 0.00293906504926364 NA NA NA hsa-let-7a-3p PRKAA1 0.0677487960013088 0.460458477653989 -0.260138732323892 1.69329749121311e-05 MirTarget;mirMAP -0.170664098061315 3.04825742143563e-06 NA NA NA hsa-miR-128-3p PRKAA1 0.475045893035043 2.6255647468e-06 -0.260138732323892 1.69329749121311e-05 miRNAWalker2_validate -0.121392157891865 0.000212770714197567 NA NA NA hsa-miR-130b-3p PRKAA1 1.12788913578446 2.939369462276e-16 -0.260138732323892 1.69329749121311e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.140926378841502 5.73673657565669e-10 NA NA NA hsa-miR-152-3p PRKAA1 0.187079360533734 0.052276214844753 -0.260138732323892 1.69329749121311e-05 MirTarget -0.127797532450855 0.000252135257660719 NA NA NA hsa-miR-15a-5p PRKAA1 1.42663930007845 1.36006952074963e-57 -0.260138732323892 1.69329749121311e-05 MirTarget -0.146530517368934 2.79850891711554e-06 NA NA NA hsa-miR-15b-5p PRKAA1 0.773001494057531 1.71784656078957e-16 -0.260138732323892 1.69329749121311e-05 MirTarget -0.105659311284572 0.00205882307559636 NA NA NA hsa-miR-361-5p PRKAA1 0.0514169367202078 0.382929376393199 -0.260138732323892 1.69329749121311e-05 miRanda;mirMAP -0.196767314147676 0.000754478998270746 NA NA NA hsa-miR-374a-5p PRKAA1 0.543061152108237 2.19403097299769e-14 -0.260138732323892 1.69329749121311e-05 mirMAP -0.118837087025337 0.00982448274510836 NA NA NA hsa-miR-374b-5p PRKAA1 0.0804104684417872 0.365593963035077 -0.260138732323892 1.69329749121311e-05 mirMAP -0.160497688391478 2.28376581567227e-05 NA NA NA hsa-miR-590-3p PRKAA1 1.13702599385212 3.53435739887793e-22 -0.260138732323892 1.69329749121311e-05 MirTarget;miRanda;mirMAP -0.100422425089955 0.000171693829819552 NA NA NA hsa-miR-590-5p PRKAA1 0.709763558412506 1.11883921359361e-11 -0.260138732323892 1.69329749121311e-05 miRanda -0.118338434930148 0.000141551861605981 NA NA NA hsa-let-7f-1-3p PRKAA2 0.477913872379336 4.46669616865068e-05 -0.87603866571455 2.39442780121668e-15 mirMAP -0.263780540038395 5.50956898532686e-06 NA NA NA hsa-let-7i-5p PRKAA2 0.911372377723717 7.11483853341932e-31 -0.87603866571455 2.39442780121668e-15 MirTarget -0.521340871347098 3.51797118269534e-13 NA NA NA hsa-miR-106b-5p PRKAA2 1.07509411417907 2.11739194181878e-36 -0.87603866571455 2.39442780121668e-15 mirMAP -0.561008419639695 1.40295355889575e-18 NA NA NA hsa-miR-130b-3p PRKAA2 1.12788913578446 2.939369462276e-16 -0.87603866571455 2.39442780121668e-15 MirTarget -0.442606148320967 1.57359763568885e-27 NA NA NA hsa-miR-142-5p PRKAA2 1.88417391525707 1.2096808039882e-27 -0.87603866571455 2.39442780121668e-15 mirMAP -0.277329590795613 6.87769379184724e-18 NA NA NA hsa-miR-146a-5p PRKAA2 1.04938133739924 7.51013231709992e-12 -0.87603866571455 2.39442780121668e-15 MirTarget -0.22387192538863 1.50880432870166e-08 NA NA NA hsa-miR-146b-5p PRKAA2 1.40714170253819 2.9559871816487e-12 -0.87603866571455 2.39442780121668e-15 MirTarget -0.197867525814189 2.66987004459186e-11 NA NA NA hsa-miR-15b-3p PRKAA2 1.49422666971434 5.44139893275088e-29 -0.87603866571455 2.39442780121668e-15 mirMAP -0.231141735708372 7.80830768962165e-08 NA NA NA hsa-miR-16-2-3p PRKAA2 1.3046118743965 4.17207934608428e-19 -0.87603866571455 2.39442780121668e-15 mirMAP -0.259009177069492 1.20025521537756e-10 NA NA NA hsa-miR-17-5p PRKAA2 0.494260110870015 3.8348005261e-09 -0.87603866571455 2.39442780121668e-15 mirMAP -0.347407802884451 2.81209053239223e-06 NA NA NA hsa-miR-181a-5p PRKAA2 1.11111114875339 3.97880443756442e-29 -0.87603866571455 2.39442780121668e-15 mirMAP -0.244417397371591 3.05181640540662e-05 NA NA NA hsa-miR-181b-5p PRKAA2 1.49054296272357 3.69051660739368e-41 -0.87603866571455 2.39442780121668e-15 mirMAP -0.255999432850681 3.01615915831125e-07 NA NA NA hsa-miR-181c-5p PRKAA2 0.762784646696248 4.48373118147729e-10 -0.87603866571455 2.39442780121668e-15 mirMAP -0.211874970274251 2.73927951901985e-05 NA NA NA hsa-miR-186-5p PRKAA2 0.507217561043443 9.04455748270995e-10 -0.87603866571455 2.39442780121668e-15 MirTarget -0.205513902010596 0.00674376562749577 NA NA NA hsa-miR-19a-3p PRKAA2 0.722913586880779 2.76301458932381e-10 -0.87603866571455 2.39442780121668e-15 mirMAP -0.241221027262891 7.49463504984831e-06 NA NA NA hsa-miR-19b-3p PRKAA2 0.195940928879427 0.0300512922542325 -0.87603866571455 2.39442780121668e-15 mirMAP -0.289198255059485 4.25737427760059e-05 NA NA NA hsa-miR-20a-5p PRKAA2 0.702602695798242 4.06372887613329e-13 -0.87603866571455 2.39442780121668e-15 mirMAP -0.310012573471448 8.78891253965596e-07 NA NA NA hsa-miR-21-3p PRKAA2 1.78837590049697 1.41655409877312e-33 -0.87603866571455 2.39442780121668e-15 mirMAP -0.304749202368708 2.06454181165912e-16 NA NA NA hsa-miR-22-5p PRKAA2 -0.197038086012602 0.106234828461117 -0.87603866571455 2.39442780121668e-15 mirMAP -0.27261107883516 1.32334602748247e-07 NA NA NA hsa-miR-23a-3p PRKAA2 0.761438723382355 4.09310879199257e-27 -0.87603866571455 2.39442780121668e-15 mirMAP -0.427046075647863 2.69308141781555e-07 NA NA NA hsa-miR-301a-3p PRKAA2 0.259400847075798 0.0216890736701418 -0.87603866571455 2.39442780121668e-15 MirTarget -0.179107497760408 0.00152284038984636 NA NA NA hsa-miR-330-3p PRKAA2 0.912906550436308 3.35037014057665e-13 -0.87603866571455 2.39442780121668e-15 MirTarget -0.186398510055617 0.000189815043894567 NA NA NA hsa-miR-340-5p PRKAA2 1.14479851941741 2.91936881701444e-15 -0.87603866571455 2.39442780121668e-15 MirTarget -0.165779558262072 7.46810073042114e-05 NA NA NA hsa-miR-342-3p PRKAA2 1.4124432570595 1.07208971556131e-28 -0.87603866571455 2.39442780121668e-15 PITA -0.322613739383616 3.97034498752305e-13 NA NA NA hsa-miR-34a-5p PRKAA2 1.07544567720768 1.81510842038009e-20 -0.87603866571455 2.39442780121668e-15 miRNATAP -0.285122269195656 2.171285185067e-08 NA NA NA hsa-miR-374a-3p PRKAA2 1.13863935833993 2.79089304015401e-44 -0.87603866571455 2.39442780121668e-15 mirMAP -0.297581680432823 1.21073366123278e-05 NA NA NA hsa-miR-381-3p PRKAA2 -0.674906433524392 0.000234722307243307 -0.87603866571455 2.39442780121668e-15 MirTarget;mirMAP -0.125306211680771 0.000300417588748376 NA NA NA hsa-miR-382-5p PRKAA2 -0.318998563236146 0.0916726793289812 -0.87603866571455 2.39442780121668e-15 mirMAP -0.14950254744342 1.27894318008159e-05 NA NA NA hsa-miR-409-3p PRKAA2 -0.292481246887274 0.114186058216271 -0.87603866571455 2.39442780121668e-15 mirMAP -0.11250926731011 0.00118969485149345 NA NA NA hsa-miR-410-3p PRKAA2 -0.34067549519883 0.0571044968648058 -0.87603866571455 2.39442780121668e-15 MirTarget -0.118633935727201 0.00131070193754933 NA NA NA hsa-miR-452-3p PRKAA2 1.72039996672257 1.35748079442153e-22 -0.87603866571455 2.39442780121668e-15 mirMAP -0.131012616507734 0.000138020148054189 NA NA NA hsa-miR-454-3p PRKAA2 0.68285296887698 1.17407812677787e-08 -0.87603866571455 2.39442780121668e-15 MirTarget -0.237942271368452 4.23432285905385e-06 NA NA NA hsa-miR-576-5p PRKAA2 1.06681109513983 5.69294424466526e-24 -0.87603866571455 2.39442780121668e-15 mirMAP -0.279376628619257 5.01651126211661e-07 NA NA NA hsa-miR-589-5p PRKAA2 0.696241532021631 5.26958362886071e-16 -0.87603866571455 2.39442780121668e-15 MirTarget -0.312536653582043 1.02510906411518e-05 NA NA NA hsa-miR-590-3p PRKAA2 1.13702599385212 3.53435739887793e-22 -0.87603866571455 2.39442780121668e-15 mirMAP;miRNATAP -0.302232071708348 1.39119727787578e-09 NA NA NA hsa-miR-93-5p PRKAA2 1.37365940377595 2.37567548683245e-46 -0.87603866571455 2.39442780121668e-15 mirMAP -0.354497458287063 3.00032412864335e-10 NA NA NA hsa-miR-142-5p PRKCA 1.88417391525707 1.2096808039882e-27 -1.40949595564765 3.30510040485645e-31 mirMAP -0.203326926537334 1.32429030012509e-07 NA NA NA hsa-miR-146a-5p PRKCA 1.04938133739924 7.51013231709992e-12 -1.40949595564765 3.30510040485645e-31 mirMAP -0.138636449569245 0.00290151925750071 NA NA NA hsa-miR-150-5p PRKCA 1.00371863159681 1.09871676395528e-09 -1.40949595564765 3.30510040485645e-31 mirMAP -0.141463696474327 0.00116284963615584 NA NA NA hsa-miR-17-3p PRKCA 0.723795600017259 5.90151677164931e-18 -1.40949595564765 3.30510040485645e-31 miRNAWalker2_validate -0.55301268177802 1.37146521298911e-11 NA NA NA hsa-miR-181a-5p PRKCA 1.11111114875339 3.97880443756442e-29 -1.40949595564765 3.30510040485645e-31 mirMAP -0.540264161188695 1.18526956498458e-16 NA NA NA hsa-miR-181b-5p PRKCA 1.49054296272357 3.69051660739368e-41 -1.40949595564765 3.30510040485645e-31 mirMAP -0.473733908349652 2.1676855775351e-17 NA NA NA hsa-miR-181c-5p PRKCA 0.762784646696248 4.48373118147729e-10 -1.40949595564765 3.30510040485645e-31 mirMAP -0.256287812602341 1.11910895047438e-05 NA NA NA hsa-miR-186-5p PRKCA 0.507217561043443 9.04455748270995e-10 -1.40949595564765 3.30510040485645e-31 miRNATAP -0.239864584666343 0.00624473839846306 NA NA NA hsa-miR-19b-1-5p PRKCA 0.66692013055553 1.55789130176287e-09 -1.40949595564765 3.30510040485645e-31 mirMAP -0.193605809138291 0.00310670883960429 NA NA NA hsa-miR-224-5p PRKCA 2.84654230414912 3.0480927226395e-47 -1.40949595564765 3.30510040485645e-31 mirMAP -0.224468346181721 5.75169704731423e-13 NA NA NA hsa-miR-2355-3p PRKCA 1.32757890426926 1.88016636795886e-18 -1.40949595564765 3.30510040485645e-31 mirMAP -0.261610517007587 1.83229270594567e-08 NA NA NA hsa-miR-3170 PRKCA 0.664452094631118 2.78926402033808e-05 -1.40949595564765 3.30510040485645e-31 mirMAP -0.143525555001005 0.00205070350789402 NA NA NA hsa-miR-330-3p PRKCA 0.912906550436308 3.35037014057665e-13 -1.40949595564765 3.30510040485645e-31 mirMAP -0.261128612369017 5.50369517469821e-06 NA NA NA hsa-miR-340-5p PRKCA 1.14479851941741 2.91936881701444e-15 -1.40949595564765 3.30510040485645e-31 mirMAP -0.258076358061294 7.18198801898922e-08 NA NA NA hsa-miR-374a-3p PRKCA 1.13863935833993 2.79089304015401e-44 -1.40949595564765 3.30510040485645e-31 mirMAP -0.684628765839887 6.42429291388675e-20 NA NA NA hsa-miR-374a-5p PRKCA 0.543061152108237 2.19403097299769e-14 -1.40949595564765 3.30510040485645e-31 mirMAP -0.522893225273422 1.47637062832505e-07 NA NA NA hsa-miR-452-5p PRKCA 2.05325688842141 2.82238393643084e-40 -1.40949595564765 3.30510040485645e-31 mirMAP -0.33224472833984 1.34300342334138e-16 NA NA NA hsa-miR-590-3p PRKCA 1.13702599385212 3.53435739887793e-22 -1.40949595564765 3.30510040485645e-31 PITA;miRanda;mirMAP;miRNATAP -0.332392461839564 9.25847276505916e-09 NA NA NA hsa-miR-592 PRKCA 2.6404220268798 8.81369998128794e-32 -1.40949595564765 3.30510040485645e-31 miRNATAP -0.172568846986646 3.52884206079864e-09 NA NA NA hsa-let-7b-5p PRLR 0.770868211539597 6.63408323707647e-21 -2.33157610117756 4.45365623526936e-19 miRNATAP -1.0005583123768 6.8819914657881e-09 NA NA NA hsa-let-7i-5p PRLR 0.911372377723717 7.11483853341932e-31 -2.33157610117756 4.45365623526936e-19 miRNATAP -1.30467344994099 2.32535623464079e-14 NA NA NA hsa-miR-130b-3p PRLR 1.12788913578446 2.939369462276e-16 -2.33157610117756 4.45365623526936e-19 mirMAP -0.509352084667327 1.11771517839996e-06 NA NA NA hsa-miR-146b-5p PRLR 1.40714170253819 2.9559871816487e-12 -2.33157610117756 4.45365623526936e-19 mirMAP -0.21171601343598 0.0037686277409964 NA NA NA hsa-miR-15b-3p PRLR 1.49422666971434 5.44139893275088e-29 -2.33157610117756 4.45365623526936e-19 mirMAP -0.384665188853191 0.000224416743379344 NA NA NA hsa-miR-16-1-3p PRLR 1.51429140700091 3.17219833254498e-37 -2.33157610117756 4.45365623526936e-19 mirMAP -0.481601739803053 3.11352685541326e-05 NA NA NA hsa-miR-181a-5p PRLR 1.11111114875339 3.97880443756442e-29 -2.33157610117756 4.45365623526936e-19 miRNAWalker2_validate;miRNATAP -0.826948573257886 2.31582068102425e-09 NA NA NA hsa-miR-181b-5p PRLR 1.49054296272357 3.69051660739368e-41 -2.33157610117756 4.45365623526936e-19 miRNATAP -0.788166705426133 2.41604924801189e-11 NA NA NA hsa-miR-181c-5p PRLR 0.762784646696248 4.48373118147729e-10 -2.33157610117756 4.45365623526936e-19 miRNATAP -0.974996882335858 4.96003851392019e-17 NA NA NA hsa-miR-186-5p PRLR 0.507217561043443 9.04455748270995e-10 -2.33157610117756 4.45365623526936e-19 mirMAP -0.527858024162186 0.00363227063785654 NA NA NA hsa-miR-196a-5p PRLR 0.440858887700369 2.0077143292463e-05 -2.33157610117756 4.45365623526936e-19 miRNATAP -0.476692298670046 0.00114256997158285 NA NA NA hsa-miR-19b-1-5p PRLR 0.66692013055553 1.55789130176287e-09 -2.33157610117756 4.45365623526936e-19 mirMAP -0.658896610022628 8.7537866772563e-07 NA NA NA hsa-miR-20a-3p PRLR -0.112128426252791 0.346272219285942 -2.33157610117756 4.45365623526936e-19 mirMAP -0.366545379247601 0.00446864488559455 NA NA NA hsa-miR-320a PRLR 0.412740558379182 2.02929519701706e-05 -2.33157610117756 4.45365623526936e-19 miRanda -0.942024787290485 8.27669367314301e-10 NA NA NA hsa-miR-320b PRLR 0.300497419754843 0.0245219177384172 -2.33157610117756 4.45365623526936e-19 miRanda -0.565616571531024 5.38648880476492e-07 NA NA NA hsa-miR-340-5p PRLR 1.14479851941741 2.91936881701444e-15 -2.33157610117756 4.45365623526936e-19 mirMAP -0.345027649962491 0.000598693374588384 NA NA NA hsa-miR-374a-3p PRLR 1.13863935833993 2.79089304015401e-44 -2.33157610117756 4.45365623526936e-19 mirMAP -0.635263456622248 0.00010074348398504 NA NA NA hsa-miR-454-3p PRLR 0.68285296887698 1.17407812677787e-08 -2.33157610117756 4.45365623526936e-19 mirMAP -0.449308028087524 0.000312865069244154 NA NA NA hsa-miR-455-5p PRLR 0.773674551205946 2.12957541541474e-09 -2.33157610117756 4.45365623526936e-19 miRanda -0.338445642310627 0.00338559723838809 NA NA NA hsa-miR-576-5p PRLR 1.06681109513983 5.69294424466526e-24 -2.33157610117756 4.45365623526936e-19 mirMAP -0.763771962747565 7.78783160172633e-09 NA NA NA hsa-miR-7-1-3p PRLR 0.544601828025304 5.33830451326047e-07 -2.33157610117756 4.45365623526936e-19 mirMAP -0.45833044684731 0.000942752381945947 NA NA NA hsa-miR-29a-3p PTEN -0.431613225927952 4.10166815070288e-08 1.35331762640689e-05 0.999813255097342 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.135012599615265 0.000683842854888072 23994196;26471361;27523474 The most importance is that we identify two miRNAs miR-222 and miR-29a involved in drug-resistance at least in part via targeting PTEN;Mechanistically ATDC exerted its oncogenic effects by suppressing miR-29 and subsequent upregulation of DNMT3A leading to DNA methylation and silencing of the tumor suppressor PTEN;RT-qPCR and Western blot results showed that downregulation of miR-29a expression in MCF-7/ADR cells increased PTEN expression levels resulting in decreased phospho-Akt p-Akt and phospho-GSK3β p-GSK3β expression; Conversely upregulation of miR-29a expression in MCF-7/S cells is associated with decreasing PTEN expression and increasing p-Akt and p-GSK3β expression; PTEN and GSK3β are targeted by miR-29a and miR-29a may contribute to ADR resistance through inhibition of the PTEN/AKT/GSK3β pathway in breast cancer cells drug resistance;;drug resistance breast cancer;bladder cancer;breast cancer hsa-miR-29b-3p PTEN -0.228125979913806 0.0271621721891603 1.35331762640689e-05 0.999813255097342 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.100056054199315 0.00111762357715794 26471361;23179556;26063204;21359530 Mechanistically ATDC exerted its oncogenic effects by suppressing miR-29 and subsequent upregulation of DNMT3A leading to DNA methylation and silencing of the tumor suppressor PTEN;Anticancer role of MUC1 aptamer miR 29b chimera in epithelial ovarian carcinoma cells through regulation of PTEN methylation; Our study indicated that Chi-29b chimera can effectively exert antitumor effect through specific delivery of miR-29b into OVCAR-3 tumor cells subsequently reexpressing PTEN gene and inducing cell apoptosis;Furthermore the dual-luciferase reporter assay demonstrated that miR-29b inhibited the expression of the luciferase gene containing the 3'-UTRs of MMP2 and PTEN mRNA;In contrast enhanced miR-29b expression by transfection with pre-miR-29b decreased the expression of PTEN and impaired apoptosis increasing tumor cell migration and invasion; Moreover PTEN was shown to be a direct target of miR-29b and was also shown to contribute to the miR-29b-mediated effects on cell invasion; Modulation of miR-29b altered the role of PTEN involved in cell migration and invasion; Aberrant expression of miR-29b which modulates PTEN expression can contribute to migration invasion and anti-apoptosis ;;;cell migration bladder cancer;ovarian cancer;lung squamous cell cancer;breast cancer hsa-miR-30d-3p PTEN -0.249777194282131 0.00235356711813496 1.35331762640689e-05 0.999813255097342 MirTarget;miRNATAP -0.108217197085104 0.0052474492839592 NA NA NA hsa-miR-146b-3p RAF1 1.20941495066078 2.12939149602665e-10 -0.729326295365523 1.03493473489106e-42 MirTarget;PITA;miRNATAP -0.126960331865385 9.60010767311038e-15 NA NA NA hsa-miR-15a-5p RAF1 1.42663930007845 1.36006952074963e-57 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.324293625748972 2.12345656575569e-29 NA NA NA hsa-miR-15b-5p RAF1 0.773001494057531 1.71784656078957e-16 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.217283143578276 6.68293363881507e-11 NA NA NA hsa-miR-16-5p RAF1 0.934012514027655 4.85417898318515e-24 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.2832583907681 1.12454604973701e-18 26527888 Besides we identify that Raf1 is a direct target of miR-15a/b miR-16 and miR-195 by dual luciferase reporter assay thyroid cancer hsa-miR-186-5p RAF1 0.507217561043443 9.04455748270995e-10 -0.729326295365523 1.03493473489106e-42 miRNAWalker2_validate -0.248932939680122 1.31766215047697e-10 NA NA NA hsa-miR-195-5p RAF1 0.346502644882604 0.0092562828415903 -0.729326295365523 1.03493473489106e-42 miRTarBase;MirTarget;miRNATAP -0.106749755319653 1.79108008549216e-05 26527888;21350001;27153315;23760062 miR 195 is a key regulator of Raf1 in thyroid cancer; Besides we identify that Raf1 is a direct target of miR-15a/b miR-16 and miR-195 by dual luciferase reporter assay; Furthermore exogenous overexpression of miR-195 significantly inhibits the protein expression of Raf1 and blocks the thyroid cancer cell proliferation;Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;IGF2BP2 promotes colorectal cancer cell proliferation and survival through interfering with RAF 1 degradation by miR 195; Molecular function analyses revealed that IGF2BP2 regulates RAF1 expression through blocking its degradation by miR-195;Upregulation of miR 195 increases the sensitivity of breast cancer cells to Adriamycin treatment through inhibition of Raf 1; The data showed that miR-195 expression was low in breast cancer cells and multidrug-resistant breast cancer tissues which was associated with reduced Raf-1 expression in vitro and ex vivo; Induction of miR-195 expression promoted tumor cell apoptosis and inhibited breast cancer cell viability but induced the sensitivity of breast cancer cells to Adriamycin treatment and was associated with inhibition of Raf-1 expression in breast cancer cells; Moreover knockdown of Raf-1 expression had similar effects of miR-195 mimics on breast cancer cells both of which were able to suppress Bcl-2 and P-glycoprotein expression in breast cancer cells; The data from the current study demonstrated that expression of miR-195 was inversely associated with Raf-1 expression in breast cancer cell lines and tissue specimens and that Raf-1 is the target gene of miR-195 ;;poor survival; thyroid cancer;breast cancer;colorectal cancer;breast cancer hsa-miR-19a-3p RAF1 0.722913586880779 2.76301458932381e-10 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.154284306170029 3.61502307447547e-08 NA NA NA hsa-miR-19b-3p RAF1 0.195940928879427 0.0300512922542325 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.115125075816159 0.00199179078014951 NA NA NA hsa-miR-331-3p RAF1 0.431607034018882 6.83022920590941e-05 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.158262304030351 1.65741452145876e-07 NA NA NA hsa-miR-484 RAF1 0.571987778099603 9.67278224458421e-10 -0.729326295365523 1.03493473489106e-42 MirTarget -0.240322437451901 1.50205113397331e-12 NA NA NA hsa-miR-497-5p RAF1 0.227757383708836 0.0600073987853074 -0.729326295365523 1.03493473489106e-42 miRTarBase;MirTarget;miRNATAP -0.119677885863477 1.30076085946277e-05 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-590-3p RAF1 1.13702599385212 3.53435739887793e-22 -0.729326295365523 1.03493473489106e-42 miRanda -0.179633605652733 4.3114164233555e-12 NA NA NA hsa-miR-93-3p RAF1 0.379664250785728 9.76327751780657e-05 -0.729326295365523 1.03493473489106e-42 miRNATAP -0.192339109650426 1.01632622523622e-08 NA NA NA hsa-miR-942-5p RAF1 0.978672610596303 3.12802933163696e-12 -0.729326295365523 1.03493473489106e-42 MirTarget -0.130737374750736 7.69722175616835e-09 NA NA NA hsa-miR-106b-5p RBL2 1.07509411417907 2.11739194181878e-36 -0.492285158562142 2.31813132529473e-11 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.370917560757112 6.37127430556685e-19 NA NA NA hsa-miR-107 RBL2 0.140046250553248 0.0943611632552367 -0.492285158562142 2.31813132529473e-11 miRanda -0.155017799372169 0.00210561865292678 NA NA NA hsa-miR-1287-5p RBL2 0.499663372173161 1.4044292587176e-07 -0.492285158562142 2.31813132529473e-11 MirTarget -0.236883032023111 3.0825077023416e-08 NA NA NA hsa-miR-140-5p RBL2 0.504309496243674 3.09884038729031e-11 -0.492285158562142 2.31813132529473e-11 miRanda -0.239400032917795 7.83611524570073e-06 NA NA NA hsa-miR-142-5p RBL2 1.88417391525707 1.2096808039882e-27 -0.492285158562142 2.31813132529473e-11 PITA -0.124237906623343 1.13906595959395e-08 NA NA NA hsa-miR-17-5p RBL2 0.494260110870015 3.8348005261e-09 -0.492285158562142 2.31813132529473e-11 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.141253882933366 0.00403048723423738 NA NA NA hsa-miR-23a-3p RBL2 0.761438723382355 4.09310879199257e-27 -0.492285158562142 2.31813132529473e-11 MirTarget -0.258886227782924 2.09768372837682e-06 NA NA NA hsa-miR-421 RBL2 0.313155739887734 0.020433534776003 -0.492285158562142 2.31813132529473e-11 miRanda -0.128406744480631 5.26845191576896e-05 NA NA NA hsa-miR-576-5p RBL2 1.06681109513983 5.69294424466526e-24 -0.492285158562142 2.31813132529473e-11 MirTarget;PITA -0.109837520221925 0.0029080433374465 NA NA NA hsa-miR-590-3p RBL2 1.13702599385212 3.53435739887793e-22 -0.492285158562142 2.31813132529473e-11 miRanda -0.165301307575792 5.43802998487753e-07 NA NA NA hsa-miR-93-5p RBL2 1.37365940377595 2.37567548683245e-46 -0.492285158562142 2.31813132529473e-11 MirTarget;miRNATAP -0.16444904218248 1.13432071033444e-05 NA NA NA hsa-miR-30e-5p RELA -0.0905907245198101 0.21196704484334 0.305834629484614 4.05322273913174e-11 miRNAWalker2_validate -0.103369294516701 0.00471206012122476 NA NA NA hsa-miR-144-5p RELN 1.47329317992706 4.31620137156824e-12 -3.07894553306265 9.85428420119065e-21 MirTarget -0.291574526955734 0.000894346592376298 NA NA NA hsa-miR-15a-5p RELN 1.42663930007845 1.36006952074963e-57 -3.07894553306265 9.85428420119065e-21 MirTarget;miRNATAP -1.14321107327099 1.3246657858663e-10 NA NA NA hsa-miR-16-5p RELN 0.934012514027655 4.85417898318515e-24 -3.07894553306265 9.85428420119065e-21 MirTarget;miRNATAP -0.757646275702114 0.000104106307387216 NA NA NA hsa-miR-193a-5p RELN 1.29777740059595 2.16815694068336e-39 -3.07894553306265 9.85428420119065e-21 PITA -0.893170253417632 1.95887072161321e-07 NA NA NA hsa-miR-195-5p RELN 0.346502644882604 0.0092562828415903 -3.07894553306265 9.85428420119065e-21 MirTarget;miRNATAP -0.427050534494542 0.00331455592861266 NA NA NA hsa-miR-224-5p RELN 2.84654230414912 3.0480927226395e-47 -3.07894553306265 9.85428420119065e-21 MirTarget -0.472339545619162 1.31493675126322e-08 NA NA NA hsa-miR-27a-3p RELN 0.558934437526245 1.44256383086177e-12 -3.07894553306265 9.85428420119065e-21 MirTarget;miRNATAP -0.695361159783646 0.00371387413691466 NA NA NA hsa-miR-338-5p RELN 0.628429807914222 1.27575140717947e-06 -3.07894553306265 9.85428420119065e-21 PITA -0.632261777795597 2.2245758861189e-05 NA NA NA hsa-miR-452-5p RELN 2.05325688842141 2.82238393643084e-40 -3.07894553306265 9.85428420119065e-21 MirTarget -0.673279775600207 4.49349583574773e-10 NA NA NA hsa-miR-590-3p RELN 1.13702599385212 3.53435739887793e-22 -3.07894553306265 9.85428420119065e-21 miRanda;miRNATAP -0.778999381846853 3.50695599022014e-07 NA NA NA hsa-miR-338-5p RHEB 0.628429807914222 1.27575140717947e-06 -0.104787111957932 0.127227094860821 MirTarget;PITA;miRNATAP -0.167905557267255 4.63175919787163e-09 NA NA NA hsa-miR-652-3p RPS6 -0.204082397854575 0.0116383615097732 0.449152759767772 1.98262666572569e-09 miRNAWalker2_validate -0.16820732198418 0.00137735696499373 NA NA NA hsa-miR-744-5p RPS6 -0.348985243196771 0.000187889982228835 0.449152759767772 1.98262666572569e-09 miRNAWalker2_validate -0.175897996517356 8.93552190904733e-05 NA NA NA hsa-miR-27b-3p RPS6KB1 -0.699527231242518 1.07356023759234e-15 0.303647491711929 1.02371800091672e-12 MirTarget;miRNATAP -0.172730029206028 2.47756684572158e-11 NA NA NA hsa-miR-30a-5p RPS6KB1 -0.778411951775343 2.73322451127932e-16 0.303647491711929 1.02371800091672e-12 mirMAP;miRNATAP -0.103881286441487 1.65257096229915e-05 NA NA NA hsa-miR-30b-5p RPS6KB1 -1.18330589477119 6.8341618466966e-27 0.303647491711929 1.02371800091672e-12 mirMAP -0.127044992502865 1.09039842876316e-10 NA NA NA hsa-miR-125a-5p RPS6KB2 -0.561874059994802 7.3931856356891e-13 0.641017701791616 2.75511443301856e-15 miRanda -0.395210282665904 2.31643815758657e-12 NA NA NA hsa-miR-1296-5p RPS6KB2 -0.992767487650773 3.35721559985878e-13 0.641017701791616 2.75511443301856e-15 miRNAWalker2_validate -0.144382822212672 1.07027776390907e-05 NA NA NA hsa-miR-326 SGK2 0.0283498662828876 0.83943976716391 -2.18361963147721 1.26182755868757e-32 miRanda -0.29963107881056 0.000184496517308946 NA NA NA hsa-miR-330-5p SGK2 1.44960468659754 2.12131210588035e-45 -2.18361963147721 1.26182755868757e-32 miRanda -0.90536433862567 1.73197028991633e-24 NA NA NA hsa-miR-455-5p SGK2 0.773674551205946 2.12957541541474e-09 -2.18361963147721 1.26182755868757e-32 miRanda -0.400573596998734 1.82300153864798e-06 NA NA NA hsa-miR-22-5p SOS1 -0.197038086012602 0.106234828461117 0.165657937822672 0.00695508624793917 miRNATAP -0.1259671249937 4.71993758199897e-06 NA NA NA hsa-miR-27b-3p SOS1 -0.699527231242518 1.07356023759234e-15 0.165657937822672 0.00695508624793917 MirTarget;miRNATAP -0.147080230611449 7.31565228121447e-05 NA NA NA hsa-miR-30b-5p SOS1 -1.18330589477119 6.8341618466966e-27 0.165657937822672 0.00695508624793917 mirMAP -0.138149072736721 7.79904823834726e-07 NA NA NA hsa-miR-361-5p SOS1 0.0514169367202078 0.382929376393199 0.165657937822672 0.00695508624793917 miRanda -0.17245343753156 0.00341644954529283 NA NA NA hsa-miR-130b-3p SOS2 1.12788913578446 2.939369462276e-16 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.219389641555847 2.49951089457902e-14 NA NA NA hsa-miR-146b-5p SOS2 1.40714170253819 2.9559871816487e-12 -0.603803978860436 7.13914474388309e-16 miRanda -0.147776164302161 1.19506749629666e-13 NA NA NA hsa-miR-15a-5p SOS2 1.42663930007845 1.36006952074963e-57 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.253370307078702 1.58238296990946e-10 NA NA NA hsa-miR-15b-5p SOS2 0.773001494057531 1.71784656078957e-16 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.335211578081185 2.30658617778889e-15 NA NA NA hsa-miR-16-5p SOS2 0.934012514027655 4.85417898318515e-24 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.24200816200432 1.67224378158762e-08 NA NA NA hsa-miR-193a-3p SOS2 0.849206638484406 3.68101781083335e-14 -0.603803978860436 7.13914474388309e-16 PITA;miRanda;miRNATAP -0.269886140589803 4.58383896803507e-14 NA NA NA hsa-miR-21-5p SOS2 2.51462371613332 3.30620591950316e-66 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.237021856922544 1.01167070366515e-26 NA NA NA hsa-miR-301a-3p SOS2 0.259400847075798 0.0216890736701418 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.116740679991895 0.00226202627325341 NA NA NA hsa-miR-320a SOS2 0.412740558379182 2.02929519701706e-05 -0.603803978860436 7.13914474388309e-16 miRanda;miRNATAP -0.205432651949533 2.81576440891282e-06 NA NA NA hsa-miR-320b SOS2 0.300497419754843 0.0245219177384172 -0.603803978860436 7.13914474388309e-16 miRanda;miRNATAP -0.152878780959194 1.68250949578106e-06 NA NA NA hsa-miR-454-3p SOS2 0.68285296887698 1.17407812677787e-08 -0.603803978860436 7.13914474388309e-16 miRNATAP -0.1714669429965 9.02571972797797e-07 NA NA NA hsa-miR-590-3p SOS2 1.13702599385212 3.53435739887793e-22 -0.603803978860436 7.13914474388309e-16 miRanda;mirMAP -0.229417057761137 7.37633999411141e-12 NA NA NA hsa-miR-590-5p SOS2 0.709763558412506 1.11883921359361e-11 -0.603803978860436 7.13914474388309e-16 PITA;miRanda;miRNATAP -0.223093386542166 1.51960822756839e-08 NA NA NA hsa-miR-139-5p SPP1 -0.704802495091118 2.36904108453776e-06 -0.534175644251711 0.00146073730596245 miRanda -0.232080239064456 0.000148526247285292 NA NA NA hsa-miR-130b-5p SYK 0.92990617673277 3.75880436852717e-12 -1.01496399009294 3.08871493938577e-17 mirMAP -0.159520059548629 0.00154161589444845 NA NA NA hsa-miR-23a-3p SYK 0.761438723382355 4.09310879199257e-27 -1.01496399009294 3.08871493938577e-17 mirMAP -0.291417348643735 0.00153102394922532 NA NA NA hsa-miR-25-3p SYK 1.12016166564779 3.79069348635778e-48 -1.01496399009294 3.08871493938577e-17 mirMAP -0.331830112016493 2.19853600526109e-05 NA NA NA hsa-miR-32-5p SYK 0.407826130035097 7.26884631998646e-06 -1.01496399009294 3.08871493938577e-17 mirMAP -0.265698680241862 0.000482486025881923 NA NA NA hsa-miR-338-3p SYK 0.906250377628867 2.76970900371139e-15 -1.01496399009294 3.08871493938577e-17 miRanda -0.308814990226065 7.62863257056378e-08 NA NA NA hsa-miR-590-3p SYK 1.13702599385212 3.53435739887793e-22 -1.01496399009294 3.08871493938577e-17 miRanda;mirMAP -0.27945675063942 3.83156823457805e-07 NA NA NA hsa-miR-421 TEK 0.313155739887734 0.020433534776003 -1.65542932804087 8.29595799035816e-24 miRanda -0.258669265792757 0.000513564139358755 NA NA NA hsa-miR-455-5p TEK 0.773674551205946 2.12957541541474e-09 -1.65542932804087 8.29595799035816e-24 miRanda -0.206901755871524 0.00512583155936728 NA NA NA hsa-miR-127-3p TGFA -1.21389348740811 1.68387193137287e-11 1.36512772495958 8.9535894410598e-16 miRanda -0.235441109326585 6.39796952246005e-06 NA NA NA hsa-miR-199a-5p TGFA -1.64658415208633 1.01615659358973e-23 1.36512772495958 8.9535894410598e-16 miRNATAP -0.255748841194025 3.38916021852312e-06 NA NA NA hsa-miR-199b-5p TGFA -2.39483476763681 1.04659509514884e-17 1.36512772495958 8.9535894410598e-16 miRNATAP -0.226367264952936 7.28652915602024e-12 NA NA NA hsa-miR-29a-5p TGFA -0.519003718107105 1.03351148282116e-06 1.36512772495958 8.9535894410598e-16 mirMAP -0.356697291857125 8.62237034540277e-05 NA NA NA hsa-miR-33a-5p TGFA -1.59840463890997 1.13487952314403e-18 1.36512772495958 8.9535894410598e-16 mirMAP -0.339922665464381 1.02399423426662e-11 NA NA NA hsa-miR-429 TGFA -2.16569233119434 2.66862243626443e-37 1.36512772495958 8.9535894410598e-16 miRanda;miRNATAP -0.149026559422325 0.00374093991912977 NA NA NA hsa-miR-590-3p THBS1 1.13702599385212 3.53435739887793e-22 -0.422350939168091 0.00203641360708328 miRanda -0.199102332423063 0.00100744242039509 NA NA NA hsa-miR-671-5p THBS1 0.740296481994777 8.07053661008188e-07 -0.422350939168091 0.00203641360708328 MirTarget -0.195692881132597 9.34674725383135e-05 NA NA NA hsa-miR-139-5p THBS2 -0.704802495091118 2.36904108453776e-06 0.895321867056393 0.000269222765203446 miRanda -0.327278957005627 0.000272140669897031 NA NA NA hsa-miR-20b-5p THBS2 -1.30218163823367 6.87172815978149e-17 0.895321867056393 0.000269222765203446 MirTarget -0.271490377299147 0.00112875670067071 NA NA NA hsa-miR-29c-3p THBS2 -0.238671318446745 0.0141475322347596 0.895321867056393 0.000269222765203446 MirTarget -0.583050087821529 3.18134128753791e-05 NA NA NA hsa-miR-125a-3p THBS3 -0.372794471295036 0.000941729459601642 0.95699276206656 4.63013641408396e-21 miRanda -0.148928774536489 0.00493844751628491 NA NA NA hsa-miR-326 THBS3 0.0283498662828876 0.83943976716391 0.95699276206656 4.63013641408396e-21 PITA -0.116947030880156 0.00634959105884818 NA NA NA hsa-miR-140-5p THEM4 0.504309496243674 3.09884038729031e-11 -0.822844376195231 1.98433504595427e-39 miRanda -0.330175932648418 1.5890590344372e-11 NA NA NA hsa-miR-150-5p THEM4 1.00371863159681 1.09871676395528e-09 -0.822844376195231 1.98433504595427e-39 MirTarget -0.147354090963784 5.29869647465255e-11 NA NA NA hsa-miR-16-5p THEM4 0.934012514027655 4.85417898318515e-24 -0.822844376195231 1.98433504595427e-39 miRNAWalker2_validate -0.236243890733184 9.21602438483497e-10 NA NA NA hsa-miR-185-5p THEM4 1.05056378692621 1.31174187880682e-22 -0.822844376195231 1.98433504595427e-39 MirTarget -0.147328234419854 1.2577978142697e-05 NA NA NA hsa-miR-576-5p THEM4 1.06681109513983 5.69294424466526e-24 -0.822844376195231 1.98433504595427e-39 MirTarget -0.242572117321872 3.03624420108253e-13 NA NA NA hsa-miR-335-5p TLR2 -2.09515619961552 1.03765771499548e-25 1.47594971546909 2.17298296803724e-26 miRNAWalker2_validate -0.154978989524625 5.76472578240305e-05 NA NA NA hsa-miR-486-5p TNC 1.16748143760361 1.68410465883829e-08 -1.02056823197306 4.71471488735119e-07 PITA;miRanda -0.149577632469242 0.00534754730223606 NA NA NA hsa-miR-590-3p TNC 1.13702599385212 3.53435739887793e-22 -1.02056823197306 4.71471488735119e-07 miRanda -0.33734412499211 0.000194178786973807 NA NA NA hsa-miR-1301-3p TNXB 0.393537638993954 0.000390498879474539 -1.10526010563814 2.57290002098814e-09 miRNAWalker2_validate -0.298988020242025 0.00149215741177973 NA NA NA hsa-miR-10b-5p TP53 -0.89971464210447 1.18190532299934e-20 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate;miRTarBase -0.178289673371273 1.01311520211069e-07 NA NA NA hsa-miR-125a-5p TP53 -0.561874059994802 7.3931856356891e-13 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate;miRTarBase;miRanda -0.169369198879199 8.24720080675124e-05 26389681;21777146;23079745 Mechanistically inactivation of miR-125a during cervical carcinogenesis was caused by HPV suppression of p53 expression;In addition wild-type p53 mRNA and protein expression was increased by hsa-miR-125a-5p overexpression; Moreover blocking wild-type p53 attenuated the effect of hsa-miR-125a-5p on apoptosis; In loss-of-function experiments wild-type p53 mRNA and protein expression was decreased by blocking hsa-miR-125a-5p; The effect of hsa-miR-125a-5p inhibitor on apoptosis was also weakened by blocking wild-type p53;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity tumorigenesis;; cervical and endocervical cancer;lung cancer;liver cancer hsa-miR-125b-5p TP53 -0.825456421494266 2.13029877878434e-15 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate;miRTarBase -0.164499575889924 1.96885947372224e-07 24846940;26335100;24137477;26686386;24402874;21399871;23585871;24762088;24169356;23079745 The results revealed that hsa-miR-125b may regulate multiple biological processes and signal transduction pathways and drug-resistant occurrence is associated with cell proliferation cell apoptosis cell cycle and signaling pathways including MAPK Wnt and p53;The carboxy terminal domain of connexin 43 CT Cx43 modulates the expression of p53 by altering miR 125b expression in low grade human breast cancers; In addition CT-Cx43 was exogenously expressed in the breast cancer-derived cell line MCF-7 and its effect on the expression of miR-125b and its downstream target p53 were evaluated as well as its effect on cellular proliferation and death using MTT and LDH assays respectively; Interestingly we found that miR-125b a negative regulator of p53 exhibited an inverse expression relationship with CT-Cx43 in the breast cancer samples tested;TP53 and hsa-miR-125b were observed to form a self-adaptation association;In this study we have investigated the delivery and transfection of wild-type wt- p53 and microRNA-125b miR-125b expressing plasmid DNA in SK-LU-1 human lung adenocarcinoma cells as well as in KrasG12D/p53fl/fl KP genetically engineered mouse model of lung cancer;miR-34a is directly regulated by p53 and acts as tumor suppressor while miR-125b plays a significant role in immune response and apoptosis;In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of p53 protein in human colorectal cancer cells;In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b;A stable overexpression of miR-125b in human melanoma cell line Mel-Juso resulted in a G0/G1 cell cycle block and emergence of large cells expressing senescence markers: senescence-associated beta-galactosidase p21 p27 and p53;MiR 125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK independent pathways; Further studies reveal that p53 is regulated by miR-125b; However downregulation of the endogenous miR-125b also results in p53-independent apoptotic pathway leading to apoptosis in p53 mutated U251 cells and p53 knockdown U87 cells;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity; To show the clinical significance of these findings mutations in the DNA binding domain of p53 and promoter methylation of miR-125b were investigated; Four out of nine patients with induced SIRT7 carried mutations in the p53 gene and one patient showed hypermethylation of the miR-125b promoter region ;;;;immune resistance;;;;; gastric cancer;breast cancer;pancreatic cancer;lung cancer;cervical and endocervical cancer;colorectal cancer;prostate cancer;melanoma;glioblastoma;liver cancer hsa-miR-30d-5p TP53 -0.202727675788184 0.00659067084745794 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate -0.234010250909245 4.72794888119438e-07 NA NA NA hsa-miR-106b-5p TSC1 1.07509411417907 2.11739194181878e-36 -0.00580613989838064 0.940526093561656 miRNAWalker2_validate -0.120840871153662 0.00727646944499296 NA NA NA hsa-miR-130b-5p TSC1 0.92990617673277 3.75880436852717e-12 -0.00580613989838064 0.940526093561656 mirMAP -0.161569736231416 1.0730295312716e-07 NA NA NA hsa-miR-140-5p TSC1 0.504309496243674 3.09884038729031e-11 -0.00580613989838064 0.940526093561656 miRanda -0.165004418084686 0.00278970296993013 NA NA NA hsa-miR-142-3p TSC1 1.88928758773299 2.72985643829893e-22 -0.00580613989838064 0.940526093561656 miRanda -0.100360531766426 6.95935714452328e-07 NA NA NA hsa-miR-150-5p TSC1 1.00371863159681 1.09871676395528e-09 -0.00580613989838064 0.940526093561656 mirMAP -0.105215447234603 2.72945643857383e-05 NA NA NA hsa-miR-186-5p TSC1 0.507217561043443 9.04455748270995e-10 -0.00580613989838064 0.940526093561656 mirMAP -0.329715504594276 2.40364473068977e-11 NA NA NA hsa-miR-193a-5p TSC1 1.29777740059595 2.16815694068336e-39 -0.00580613989838064 0.940526093561656 mirMAP -0.186472134336862 8.61069871222992e-07 NA NA NA hsa-miR-197-3p TSC1 0.297760714271229 0.00102679606305048 -0.00580613989838064 0.940526093561656 mirMAP -0.248373692373176 9.00704159638638e-08 NA NA NA hsa-miR-23a-3p TSC1 0.761438723382355 4.09310879199257e-27 -0.00580613989838064 0.940526093561656 mirMAP -0.234478582453751 2.79325447109095e-05 NA NA NA hsa-miR-28-3p TSC1 1.01277915413238 1.8655970171461e-43 -0.00580613989838064 0.940526093561656 PITA -0.221693676045417 1.36868877784546e-05 NA NA NA hsa-miR-29a-5p TSC1 -0.519003718107105 1.03351148282116e-06 -0.00580613989838064 0.940526093561656 mirMAP -0.116658848056744 0.00333129068504756 NA NA NA hsa-miR-29b-1-5p TSC1 0.0773574972948876 0.542823265430415 -0.00580613989838064 0.940526093561656 mirMAP -0.143974607612096 1.70166692972594e-05 NA NA NA hsa-miR-320a TSC1 0.412740558379182 2.02929519701706e-05 -0.00580613989838064 0.940526093561656 miRNAWalker2_validate;miRanda -0.172381374186791 7.779409765497e-05 NA NA NA hsa-miR-320b TSC1 0.300497419754843 0.0245219177384172 -0.00580613989838064 0.940526093561656 miRanda -0.147538662754558 3.10353146784042e-06 NA NA NA hsa-miR-339-5p TSC1 0.322848334531193 0.0117281778821612 -0.00580613989838064 0.940526093561656 miRanda -0.156420585582284 2.07930704169104e-06 NA NA NA hsa-miR-495-3p TSC1 -0.742293735164333 7.11373308013543e-05 -0.00580613989838064 0.940526093561656 mirMAP -0.112996786535522 9.57369310781159e-07 NA NA NA hsa-miR-576-5p TSC1 1.06681109513983 5.69294424466526e-24 -0.00580613989838064 0.940526093561656 mirMAP -0.159651820548827 1.98607445752694e-05 NA NA NA hsa-miR-7-1-3p TSC1 0.544601828025304 5.33830451326047e-07 -0.00580613989838064 0.940526093561656 mirMAP -0.126117369350671 0.00113875962691901 NA NA NA hsa-miR-1-3p VEGFA -1.38047704190737 9.11649491260066e-13 3.1902151031465 4.32161998112301e-60 MirTarget -0.377004508862683 2.92409820832604e-09 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-106a-5p VEGFA -0.830908656792615 2.67547872901508e-10 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase -0.565883993248695 1.96742640916183e-09 NA NA NA hsa-miR-125a-5p VEGFA -0.561874059994802 7.3931856356891e-13 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRanda -0.691987422405189 1.65186087473265e-05 22768249 Ectopic expression of MiR 125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF; Furthermore miR-125a expression was inversely correlated with both MMP11 and VEGF-A expression in HCC tissues; MiR-125a inhibits the proliferation and metastasis of HCC by targeting MMP11 and VEGF-A metastasis liver cancer hsa-miR-133a-3p VEGFA -1.27121745308165 9.16266399887975e-11 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate -0.334559517340425 1.60041057990039e-07 NA NA NA hsa-miR-134-5p VEGFA -0.940639322366899 1.24417590236773e-06 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget -0.273283677460691 3.09936265314409e-05 NA NA NA hsa-miR-199a-5p VEGFA -1.64658415208633 1.01615659358973e-23 3.1902151031465 4.32161998112301e-60 miRanda;miRNATAP -0.582562369754787 1.33420730972332e-16 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA -2.39483476763681 1.04659509514884e-17 3.1902151031465 4.32161998112301e-60 miRanda -0.388055722385546 8.86533920644866e-20 NA NA NA hsa-miR-200b-3p VEGFA -1.70383252137161 2.38979336321755e-30 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.652162092625576 6.74456951743668e-18 20420713;22904162;25301739 We also found strong anti-correlation between VEGFA and the miR-200 family of microRNA: miR-200a* 200b 200c and miR-141;In contrast a positive correlation was observed between VEGF-A and miR-200b and -210;CCL5 promotes VEGF dependent angiogenesis by down regulating miR 200b through PI3K/Akt signaling pathway in human chondrosarcoma cells; We also demonstrated CCL5 inhibiting miR-200b expression and miR-200b mimic reversing the CCL5-enhanced VEGF expression and angiogenesis ;; kidney renal cell cancer;endometrial cancer;sarcoma hsa-miR-200c-3p VEGFA -5.40303134829523 2.74173143360645e-94 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget -0.482839305599163 5.43978252023974e-53 24205206;25445393 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway;Analysis revealed a negative correlation between miR-200c and VEGFA expressions r=-468 ; lung squamous cell cancer;breast cancer hsa-miR-20b-5p VEGFA -1.30218163823367 6.87172815978149e-17 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase -0.658858628437659 2.63194222583861e-18 22901144;20232316;26612965 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha;We investigated whether and how miR-20b can regulate the expression of vascular endothelial growth factor VEGF in MCF-7 breast cancer cells under normoxic and hypoxia-mimicking conditions CoCl2 exposure; Using immunoblotting ELISA and quantitative real-time PCR we demonstrated that miR-20b decreased VEGF protein levels at 4 and 24 h following CoCl2 treatment and VEGF mRNA at 4 h of treatment; In addition miR-20b reduced VEGF protein expression in untreated cells;Clinicopathological Significance of MicroRNA 20b Expression in Hepatocellular Carcinoma and Regulation of HIF 1α and VEGF Effect on Cell Biological Behaviour; Meanwhile the HIF-1α and VEGF targets of miR-20b have been confirmed; We found not only miR-20b regulation of HIF-1α and VEGF in normal but also regulation of miR-20b in hypoxia; The whole study suggests that miR-20b HIF-1α and VEGF serve as a potential therapeutic agent for hepatocellular carcinoma ;; breast cancer;breast cancer;liver cancer hsa-miR-29a-3p VEGFA -0.431613225927952 4.10166815070288e-08 3.1902151031465 4.32161998112301e-60 MirTarget -1.19030784245849 4.8715212353082e-14 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29b-2-5p VEGFA -0.297854154636098 0.00260919277325581 3.1902151031465 4.32161998112301e-60 MirTarget -0.376634138151447 0.00423612473269059 NA NA NA hsa-miR-29b-3p VEGFA -0.228125979913806 0.0271621721891603 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget -0.569482283980511 5.47301472525388e-06 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-335-5p VEGFA -2.09515619961552 1.03765771499548e-25 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate -0.560731405851007 4.75077750352693e-23 NA NA NA hsa-miR-362-3p VEGFA -0.753214251798232 3.0025661608035e-07 3.1902151031465 4.32161998112301e-60 miRanda -0.478977237100648 5.87028343678109e-08 NA NA NA hsa-miR-429 VEGFA -2.16569233119434 2.66862243626443e-37 3.1902151031465 4.32161998112301e-60 MirTarget;miRanda;miRNATAP -0.567681641585143 1.7112668371199e-18 NA NA NA hsa-miR-9-5p VEGFA -2.23538606210968 1.28143998950751e-12 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate -0.222102357667036 1.24335781156383e-08 NA NA NA hsa-miR-125a-5p VEGFB -0.561874059994802 7.3931856356891e-13 0.889287998012356 1.57204399120492e-27 miRanda -0.312191565292049 2.15759355844345e-07 NA NA NA hsa-miR-429 VWF -2.16569233119434 2.66862243626443e-37 3.23402000273087 1.43846196838355e-51 miRNATAP -0.65808456955946 6.02233612498167e-22 NA NA NA hsa-miR-181a-5p YWHAB 1.11111114875339 3.97880443756442e-29 -0.436649879556757 1.07574819649047e-17 mirMAP -0.157430815606491 3.72850286786433e-09 NA NA NA hsa-miR-181b-5p YWHAB 1.49054296272357 3.69051660739368e-41 -0.436649879556757 1.07574819649047e-17 mirMAP -0.148555433994048 7.04256501112272e-11 NA NA NA hsa-miR-27a-3p YWHAB 0.558934437526245 1.44256383086177e-12 -0.436649879556757 1.07574819649047e-17 MirTarget;miRNATAP -0.140096204677841 0.000109347058006503 NA NA NA hsa-miR-28-3p YWHAB 1.01277915413238 1.8655970171461e-43 -0.436649879556757 1.07574819649047e-17 mirMAP -0.128268747523935 0.000279381491821486 NA NA NA hsa-miR-590-3p YWHAB 1.13702599385212 3.53435739887793e-22 -0.436649879556757 1.07574819649047e-17 miRanda -0.114186720944627 9.10728186010718e-07 NA NA NA hsa-miR-140-5p YWHAE 0.504309496243674 3.09884038729031e-11 -0.126291713961324 0.00146652744659035 miRanda -0.147589734050215 9.44106228586763e-08 NA NA NA hsa-miR-200a-3p YWHAG -1.43409013664263 2.00188483717828e-20 0.356795537472197 2.99065123952189e-09 MirTarget;miRNATAP -0.108146282995436 8.88223977768603e-08 NA NA NA hsa-miR-200b-3p YWHAG -1.70383252137161 2.38979336321755e-30 0.356795537472197 2.99065123952189e-09 MirTarget;TargetScan -0.109950840688747 6.60623803058959e-08 NA NA NA hsa-miR-23b-3p YWHAG -0.533749586990474 2.46924776953771e-10 0.356795537472197 2.99065123952189e-09 MirTarget;miRNATAP -0.125114895596028 0.00146198575052877 NA NA NA hsa-miR-30a-5p YWHAG -0.778411951775343 2.73322451127932e-16 0.356795537472197 2.99065123952189e-09 miRNATAP -0.244666106319673 1.06273731298785e-13 NA NA NA hsa-miR-30b-5p YWHAG -1.18330589477119 6.8341618466966e-27 0.356795537472197 2.99065123952189e-09 miRNATAP -0.153808500618617 3.37747961935545e-08 NA NA NA hsa-miR-30c-5p YWHAG -1.08783070774238 2.02505402525786e-24 0.356795537472197 2.99065123952189e-09 miRNATAP -0.136382262402707 3.07275349224244e-06 NA NA NA hsa-miR-429 YWHAG -2.16569233119434 2.66862243626443e-37 0.356795537472197 2.99065123952189e-09 MirTarget;PITA;miRanda;miRNATAP -0.103261950591647 2.69299283602683e-09 NA NA NA hsa-miR-324-5p YWHAH -0.487750893426456 3.74472736457965e-05 0.879541909818469 2.70172159291526e-40 miRNAWalker2_validate -0.10780707564178 0.0018544112120671 NA NA NA hsa-miR-33a-5p YWHAH -1.59840463890997 1.13487952314403e-18 0.879541909818469 2.70172159291526e-40 miRNAWalker2_validate;MirTarget;miRNATAP -0.12503282006823 3.8785311230509e-09 NA NA NA hsa-miR-508-3p YWHAH -3.41433288024917 3.47699261121175e-37 0.879541909818469 2.70172159291526e-40 miRNATAP -0.129480004616491 4.79117076373846e-24 NA NA NA hsa-miR-30a-5p YWHAZ -0.778411951775343 2.73322451127932e-16 0.131743827589666 0.0169925785623515 miRNAWalker2_validate;MirTarget;miRNATAP -0.155632407992389 2.42076268396331e-07 NA NA NA hsa-miR-30d-5p YWHAZ -0.202727675788184 0.00659067084745794 0.131743827589666 0.0169925785623515 MirTarget;miRNATAP -0.113720265182448 0.00562868472799409 NA NA NA hsa-miR-361-5p YWHAZ 0.0514169367202078 0.382929376393199 0.131743827589666 0.0169925785623515 miRanda -0.15008979606015 0.00451477624517307 NA NA NA