miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-378a-3p ACTB 1.46612141870273 0.0466660641196872 -0.794447367262446 0.0108875680196839 miRNAWalker2_validate -0.111147457812733 2.54313440435332e-06 NA NA NA hsa-let-7a-3p AMOT 0.82512001802525 0.0468122405194487 -1.93588757754572 0.207007298744567 mirMAP -0.586327154082411 0.00567864211124293 NA NA NA hsa-let-7f-1-3p AMOT 1.61507869803314 0.00069342464777815 -1.93588757754572 0.207007298744567 mirMAP -1.02981078375557 1.06872087659459e-08 NA NA NA hsa-miR-203a-3p AMOT 6.35084246337388 7.89944323347948e-08 -1.93588757754572 0.207007298744567 MirTarget -0.401380196668431 1.14285548176709e-08 NA NA NA hsa-miR-205-5p AMOT 8.08298115900323 3.83045179398654e-07 -1.93588757754572 0.207007298744567 MirTarget;miRNATAP -0.387634181910727 4.18645361193713e-14 26239614 MicroRNA 205 inhibits the proliferation and invasion of breast cancer by regulating AMOT expression; In the present study miR-205 was significantly downregulated in breast cancer samples and it was identified to directly target the 3'-untranslated region 3'-UTR of AMOT in breast cancer MCF-7 cells by luciferase assay; miR-205 and small interfering RNA siRNA-mediated AMOT-knockdown experiments revealed that miR-205 significantly inhibited the proliferation and the invasion of MCF-7 cells through a decrease in the expression of AMOT yet had no effect on apoptosis; Furthermore we observed that the overexpression of AMOT partially reversed the inhibitory effect of miR-205 on the growth and the invasion of MCF-7 cells; The data indicated that miR-205 regulated the proliferation and the invasion of breast cancer cells through suppression of AMOT expression at least partly; Therefore the disordered decreased expression of miR-205 and the resulting AMOT upregulation contributes to breast carcinogenesis and miR-205-AMOT represents a new potential therapeutic target for the treatment of breast carcinoma tumorigenesis breast cancer hsa-miR-21-3p AMOT 3.50297439576639 6.39946844099206e-10 -1.93588757754572 0.207007298744567 mirMAP -0.741770646519656 5.00153946902612e-07 NA NA NA hsa-miR-212-3p AMOT 0.737445495924757 0.258900181983036 -1.93588757754572 0.207007298744567 MirTarget -0.430874436717647 0.00121659794060656 NA NA NA hsa-miR-22-3p AMOT 0.845430028554782 0.0148923883819448 -1.93588757754572 0.207007298744567 MirTarget;miRNATAP -1.18728875703614 2.48227248316445e-06 NA NA NA hsa-miR-221-3p AMOT 0.94082283577318 0.174749164179978 -1.93588757754572 0.207007298744567 miRNAWalker2_validate -0.852128128958684 2.32133036552586e-12 NA NA NA hsa-miR-2355-3p AMOT 0.494099635633886 0.483724014019781 -1.93588757754572 0.207007298744567 MirTarget;miRNATAP -0.719381846858275 2.76802814816744e-09 NA NA NA hsa-miR-29a-3p AMOT -0.638239697975974 0.251923581881716 -1.93588757754572 0.207007298744567 MirTarget;miRNATAP -0.559931729004755 0.000340693305602699 NA NA NA hsa-miR-29b-3p AMOT 0.666547117072858 0.234055379278093 -1.93588757754572 0.207007298744567 MirTarget;miRNATAP -0.593620184955212 0.000130832285608083 NA NA NA hsa-miR-330-3p AMOT 2.49094236945806 0.000129367003214715 -1.93588757754572 0.207007298744567 MirTarget;PITA;miRNATAP -0.633352067477425 1.41336996447985e-06 NA NA NA hsa-miR-330-5p AMOT 2.25110496739954 0.000275527655397415 -1.93588757754572 0.207007298744567 miRanda -0.639561182503311 3.63918229519739e-06 NA NA NA hsa-miR-342-3p AMOT 1.31107714473009 0.0207211910724662 -1.93588757754572 0.207007298744567 miRanda -0.675504755462537 9.08798234976305e-06 NA NA NA hsa-miR-34c-3p AMOT 4.0411891981675 0.000195495966405666 -1.93588757754572 0.207007298744567 MirTarget;mirMAP -0.248939645543746 0.00175317681505763 NA NA NA hsa-miR-34c-5p AMOT 2.64675661251039 0.0157394735757952 -1.93588757754572 0.207007298744567 miRanda -0.233135463021397 0.00314638429544818 NA NA NA hsa-miR-944 AMOT 7.20925181386398 0.000823207457340648 -1.93588757754572 0.207007298744567 mirMAP;miRNATAP -0.37876041256148 1.64092592360847e-15 NA NA NA hsa-miR-186-5p APC 0.445443449112564 0.185447310527704 -0.0767747610151472 0.842336162144662 miRNAWalker2_validate -0.186375765100707 0.00487494868289952 NA NA NA hsa-miR-30a-3p APC -1.22212086897848 0.167565797592104 -0.0767747610151472 0.842336162144662 MirTarget;miRNATAP -0.110308714220782 5.55003156650705e-06 NA NA NA hsa-miR-320b APC 0.20205459771295 0.727216419960509 -0.0767747610151472 0.842336162144662 miRanda -0.120780596736221 0.00135470702580849 NA NA NA hsa-miR-374b-5p APC -0.114749866169918 0.764888930049438 -0.0767747610151472 0.842336162144662 mirMAP -0.185591036709671 0.00127655314359827 NA NA NA hsa-miR-590-3p APC 2.35429565068338 2.79601879608564e-06 -0.0767747610151472 0.842336162144662 PITA;miRanda;mirMAP;miRNATAP -0.166334795891123 9.61904390448028e-05 NA NA NA hsa-miR-7-1-3p APC 1.43074343339835 0.00471215970502094 -0.0767747610151472 0.842336162144662 MirTarget -0.147209385006141 0.000605238293641448 NA NA NA hsa-miR-125a-5p APC2 -1.32352790615388 0.00714301627309467 3.13191261662562 0.00737055129114406 mirMAP -0.853096269997355 1.04500045510591e-10 NA NA NA hsa-miR-194-3p APC2 1.91743783341496 0.105383373371284 3.13191261662562 0.00737055129114406 mirMAP -0.158439963257808 0.00506903391988806 NA NA NA hsa-miR-28-5p APC2 -0.815636722979196 0.0221199948901761 3.13191261662562 0.00737055129114406 mirMAP -0.665871134811181 0.000433374657967794 NA NA NA hsa-let-7a-3p AXIN2 0.82512001802525 0.0468122405194487 -3.82407466660445 0.000332783445696398 miRNATAP -0.494045855852835 0.000853130932920837 NA NA NA hsa-let-7b-3p AXIN2 0.589364128513318 0.200507534602851 -3.82407466660445 0.000332783445696398 miRNATAP -0.497070558406417 0.000186469770166558 NA NA NA hsa-let-7f-2-3p AXIN2 1.02768112108475 0.0787293499732611 -3.82407466660445 0.000332783445696398 MirTarget -0.356438400092079 0.000841906314096363 NA NA NA hsa-miR-15a-5p AXIN2 2.0535411006904 1.91108976398046e-06 -3.82407466660445 0.000332783445696398 MirTarget;miRNATAP -0.550942102635856 8.04479638813504e-05 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-15b-5p AXIN2 3.32329949959268 8.40210501034588e-13 -3.82407466660445 0.000332783445696398 miRTarBase;MirTarget;miRNATAP -0.467609074192871 0.00022236000942262 NA NA NA hsa-miR-16-2-3p AXIN2 3.79845098071094 1.49120139344659e-13 -3.82407466660445 0.000332783445696398 mirMAP -0.6823456604213 9.95304651839219e-10 NA NA NA hsa-miR-16-5p AXIN2 2.93575808220754 2.15436817162977e-10 -3.82407466660445 0.000332783445696398 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.695908366314422 3.93881990567234e-08 NA NA NA hsa-miR-205-5p AXIN2 8.08298115900323 3.83045179398654e-07 -3.82407466660445 0.000332783445696398 miRNATAP -0.296107118342617 9.25850565228752e-17 NA NA NA hsa-miR-221-3p AXIN2 0.94082283577318 0.174749164179978 -3.82407466660445 0.000332783445696398 miRNATAP -0.518384723281925 1.67647878628316e-09 NA NA NA hsa-miR-222-3p AXIN2 1.54730827524553 0.0223014220569407 -3.82407466660445 0.000332783445696398 miRNATAP -0.534987790682349 1.10747648966591e-09 NA NA NA hsa-miR-3614-5p AXIN2 4.50236405439456 2.75644515847367e-07 -3.82407466660445 0.000332783445696398 MirTarget;miRNATAP -0.261864275832248 0.000119330708648269 NA NA NA hsa-miR-590-3p AXIN2 2.35429565068338 2.79601879608564e-06 -3.82407466660445 0.000332783445696398 MirTarget;PITA;miRanda;miRNATAP -0.500291647228716 2.7183686924642e-05 NA NA NA hsa-miR-944 AXIN2 7.20925181386398 0.000823207457340648 -3.82407466660445 0.000332783445696398 MirTarget;PITA;miRNATAP -0.276130498452101 8.40746733798985e-17 NA NA NA hsa-miR-139-5p BBC3 -2.09475477693654 0.000382570602748311 0.475293229786881 0.35789989855877 miRNATAP -0.156907185873873 0.00142876640678516 NA NA NA hsa-miR-101-3p BIRC5 -1.12421603598195 0.0200907284788457 6.15072763215425 1.75655420357492e-29 miRNAWalker2_validate -0.197009001363036 0.0054014730598698 NA NA NA hsa-miR-106a-5p BMP2 3.98693608217557 9.37722470816656e-07 0.595740898970527 0.596139083918881 miRNATAP -0.284756722505656 0.000196543267629134 NA NA NA hsa-miR-362-3p BMP2 0.679952485897744 0.226148468488576 0.595740898970527 0.596139083918881 miRanda -0.390686913840248 0.000600723221602875 NA NA NA hsa-miR-378c BMP2 0.449601775771001 0.4993814483956 0.595740898970527 0.596139083918881 miRNATAP -0.281129605798991 0.00340183029023861 NA NA NA hsa-miR-429 BMP2 6.39965293994036 1.96920201593608e-18 0.595740898970527 0.596139083918881 miRNATAP -0.316552444908905 0.000105772353880714 NA NA NA hsa-miR-142-3p BMP4 4.35304505457969 3.10014573651358e-10 -1.94703268163709 0.0822008874653257 PITA;miRanda -0.375958312329309 2.16964863280377e-05 NA NA NA hsa-miR-590-3p BMP4 2.35429565068338 2.79601879608564e-06 -1.94703268163709 0.0822008874653257 miRanda -0.369298014297492 0.00319363636714979 NA NA NA hsa-miR-125a-3p BMP7 -0.0748960586927341 0.920735897434087 2.47007870640865 0.141831667873887 miRanda -0.602397019762289 1.60854190307016e-06 NA NA NA hsa-miR-30a-5p BMP7 -0.768430903969183 0.320487552854215 2.47007870640865 0.141831667873887 mirMAP;miRNATAP -0.837637094666436 2.22227369883976e-12 NA NA NA hsa-miR-338-3p BMP7 0.447551118940466 0.558485097370031 2.47007870640865 0.141831667873887 miRanda -0.675850252283759 3.5099234776835e-08 NA NA NA hsa-miR-142-3p BMP8A 4.35304505457969 3.10014573651358e-10 -0.908883846447831 0.149406718545684 miRNAWalker2_validate -0.151623785619638 0.0024673264370693 NA NA NA hsa-miR-30e-3p BMP8A -0.0362193022195196 0.932577027239525 -0.908883846447831 0.149406718545684 MirTarget -0.272991487072419 0.00121157832661015 NA NA NA hsa-miR-326 BMP8A 1.76645822596029 0.0367310428720192 -0.908883846447831 0.149406718545684 miRanda -0.120244523761685 0.00459378828407528 NA NA NA hsa-miR-125a-5p BMP8B -1.32352790615388 0.00714301627309467 2.55233654308544 0.000406125109313419 miRanda -0.21763357986147 0.00972666932519359 NA NA NA hsa-miR-26b-5p BMP8B 0.314414148564179 0.461628303578321 2.55233654308544 0.000406125109313419 miRNAWalker2_validate -0.338787540773238 0.000511841503220318 NA NA NA hsa-miR-455-5p BMP8B -0.317715589860275 0.616296031007863 2.55233654308544 0.000406125109313419 miRanda -0.189702790864636 0.00364777683255093 NA NA NA hsa-miR-142-5p BMPR1B 3.95552531913424 1.49536283724079e-08 -1.52134988166544 0.343393213784145 mirMAP -0.734195251953472 3.70209244281447e-09 NA NA NA hsa-miR-146b-5p BMPR1B 1.87569569182453 0.000737241069698886 -1.52134988166544 0.343393213784145 miRanda -0.666457773194095 3.90750084541049e-05 NA NA NA hsa-miR-150-5p BMPR1B 1.76769157530064 0.0593795975117846 -1.52134988166544 0.343393213784145 MirTarget -0.474315918794335 6.64615777439564e-07 NA NA NA hsa-miR-205-5p BMPR1B 8.08298115900323 3.83045179398654e-07 -1.52134988166544 0.343393213784145 miRNATAP -0.30696104798101 2.09869521416875e-08 NA NA NA hsa-miR-23b-3p BMPR1B -0.581135273821923 0.190478897170459 -1.52134988166544 0.343393213784145 mirMAP -0.738278706558228 0.000346932652828484 NA NA NA hsa-miR-24-3p BMPR1B 1.55853749533999 0.000524726461381821 -1.52134988166544 0.343393213784145 miRNATAP -0.553792517791316 0.00634597891344123 NA NA NA hsa-miR-374a-5p BMPR1B 0.278549982012055 0.45888283715888 -1.52134988166544 0.343393213784145 MirTarget -0.875519236735069 0.000361012347481395 NA NA NA hsa-miR-590-3p BMPR1B 2.35429565068338 2.79601879608564e-06 -1.52134988166544 0.343393213784145 miRanda;mirMAP -0.552426048195125 0.00204524961517634 NA NA NA hsa-miR-629-3p BMPR1B 3.48282157979573 4.9176538695908e-08 -1.52134988166544 0.343393213784145 MirTarget -0.416162287016012 0.00285439024103792 NA NA NA hsa-let-7f-1-3p BMPR2 1.61507869803314 0.00069342464777815 -1.12630218798609 0.00109088044133536 MirTarget -0.123298671912875 0.00285602396296033 NA NA NA hsa-miR-106b-5p BMPR2 2.80565545918114 1.14547999022566e-09 -1.12630218798609 0.00109088044133536 MirTarget;miRNATAP -0.118630186532809 0.0044306068125726 NA NA NA hsa-miR-146b-3p BMPR2 1.34608871980101 0.00935728391852709 -1.12630218798609 0.00109088044133536 MirTarget;PITA -0.129887166168285 0.0005867601546192 NA NA NA hsa-miR-148b-3p BMPR2 1.75622244535669 8.84414356040579e-08 -1.12630218798609 0.00109088044133536 mirMAP -0.196466429101429 0.000987067706586972 NA NA NA hsa-miR-16-2-3p BMPR2 3.79845098071094 1.49120139344659e-13 -1.12630218798609 0.00109088044133536 mirMAP -0.146205885014432 6.2092491962501e-05 NA NA NA hsa-miR-17-5p BMPR2 2.3269271449522 2.13987445663942e-05 -1.12630218798609 0.00109088044133536 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.123193636647238 0.000494673489159658 NA NA NA hsa-miR-19b-3p BMPR2 1.67581705793313 0.000858910586302716 -1.12630218798609 0.00109088044133536 miRNAWalker2_validate;MirTarget;miRNATAP -0.150829353350739 9.76501280448681e-05 NA NA NA hsa-miR-20a-5p BMPR2 2.13553469875764 0.000181201072324354 -1.12630218798609 0.00109088044133536 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.109933280976769 0.0012552170058051 NA NA NA hsa-miR-25-3p BMPR2 1.12623030168869 0.00311079344417173 -1.12630218798609 0.00109088044133536 miRNATAP -0.161936056023317 0.00181112605669761 NA NA NA hsa-miR-30b-5p BMPR2 0.0238659735605804 0.953223658270319 -1.12630218798609 0.00109088044133536 mirMAP -0.165651429980918 0.000678402541773278 NA NA NA hsa-miR-30e-5p BMPR2 0.780047227271616 0.0346714425913016 -1.12630218798609 0.00109088044133536 mirMAP -0.152650979111587 0.00461355244700787 NA NA NA hsa-miR-32-5p BMPR2 2.93035124381469 5.00149131394151e-10 -1.12630218798609 0.00109088044133536 miRNATAP -0.152990695015064 0.000157914766251291 NA NA NA hsa-miR-590-3p BMPR2 2.35429565068338 2.79601879608564e-06 -1.12630218798609 0.00109088044133536 MirTarget;miRanda;mirMAP;miRNATAP -0.180484987835457 2.26482768248502e-06 NA NA NA hsa-miR-590-5p BMPR2 1.51400888103768 0.0023888567923017 -1.12630218798609 0.00109088044133536 MirTarget;PITA;miRNATAP -0.148168305174109 0.000153211214789233 NA NA NA hsa-miR-92a-3p BMPR2 1.87892405805529 1.27013821556583e-05 -1.12630218798609 0.00109088044133536 miRNAWalker2_validate;miRNATAP -0.198526920027066 1.013641786486e-05 NA NA NA hsa-miR-93-3p BMPR2 2.62833115374128 2.28843227834337e-07 -1.12630218798609 0.00109088044133536 miRNAWalker2_validate -0.111582243298826 0.00334043843071077 NA NA NA hsa-miR-93-5p BMPR2 2.65964181833033 2.58315947526774e-08 -1.12630218798609 0.00109088044133536 miRNAWalker2_validate;MirTarget;miRNATAP -0.125581481915172 0.00184301830288687 NA NA NA hsa-let-7e-5p BTRC -0.111012524740586 0.814744515884005 -0.389242677076138 0.229517873289865 miRNAWalker2_validate -0.157958876446546 4.3321742453e-05 NA NA NA hsa-miR-125a-3p BTRC -0.0748960586927341 0.920735897434087 -0.389242677076138 0.229517873289865 miRanda -0.111382995850356 3.64944935788154e-06 NA NA NA hsa-miR-15b-5p BTRC 3.32329949959268 8.40210501034588e-13 -0.389242677076138 0.229517873289865 MirTarget;miRNATAP -0.14366136035681 0.000149866518688636 NA NA NA hsa-miR-16-5p BTRC 2.93575808220754 2.15436817162977e-10 -0.389242677076138 0.229517873289865 miRNAWalker2_validate;MirTarget;miRNATAP -0.130265266499023 0.000715839459970842 NA NA NA hsa-miR-28-5p BTRC -0.815636722979196 0.0221199948901761 -0.389242677076138 0.229517873289865 miRanda -0.236608660977103 4.38097837138535e-06 NA NA NA hsa-miR-339-5p BTRC 1.23326828594484 0.0307501214818698 -0.389242677076138 0.229517873289865 MirTarget;miRanda -0.105080246885308 0.00100529890713538 NA NA NA hsa-miR-3913-5p BTRC 0.145645056779437 0.734844256690741 -0.389242677076138 0.229517873289865 mirMAP -0.160514640592341 0.000175552950437538 NA NA NA hsa-miR-505-3p BTRC 0.58881333170866 0.226937454637888 -0.389242677076138 0.229517873289865 MirTarget -0.103932436230113 0.00591974191859582 NA NA NA hsa-let-7a-5p CCND1 0.148081801547773 0.645305441523746 0.153161422157864 0.87752763573474 TargetScan;miRNATAP -0.543758028087025 0.00245174452713361 NA NA NA hsa-miR-106a-5p CCND1 3.98693608217557 9.37722470816656e-07 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.430943892321887 6.82894757639655e-11 NA NA NA hsa-miR-15a-5p CCND1 2.0535411006904 1.91108976398046e-06 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.345671894500985 0.00776019225008181 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 3.32329949959268 8.40210501034588e-13 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.423468924188888 0.000292921876666624 NA NA NA hsa-miR-20b-5p CCND1 4.5662923200279 4.75238200639144e-05 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.306916825629866 1.73283870424345e-10 NA NA NA hsa-miR-34a-5p CCND1 0.830377770217786 0.0477544831885907 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;miRNATAP -0.423813778518534 0.00174350326234822 25792709;21399894 This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a ; liver cancer;breast cancer hsa-miR-497-5p CCND1 -1.44150596209372 0.0225146607606395 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.249933846887954 0.00498383887238102 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-106a-5p CCND2 3.98693608217557 9.37722470816656e-07 -2.81051675901102 0.00139983736368543 miRNATAP -0.444958981451041 2.08537025757115e-14 NA NA NA hsa-miR-106b-5p CCND2 2.80565545918114 1.14547999022566e-09 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309595760343179 0.00374413339981401 NA NA NA hsa-miR-10a-3p CCND2 0.970411431936568 0.31667483998251 -2.81051675901102 0.00139983736368543 mirMAP -0.203238239783698 0.000109626077062705 NA NA NA hsa-miR-130b-5p CCND2 3.74118449312296 2.92266550966038e-10 -2.81051675901102 0.00139983736368543 mirMAP -0.460499923117218 1.14695292180331e-08 NA NA NA hsa-miR-141-3p CCND2 7.30474126597325 1.45115996357606e-24 -2.81051675901102 0.00139983736368543 MirTarget;TargetScan -0.239696704303332 0.000205435786708848 NA NA NA hsa-miR-15b-5p CCND2 3.32329949959268 8.40210501034588e-13 -2.81051675901102 0.00139983736368543 miRNATAP -0.527059068245043 3.31921597840683e-07 NA NA NA hsa-miR-16-2-3p CCND2 3.79845098071094 1.49120139344659e-13 -2.81051675901102 0.00139983736368543 mirMAP -0.289719520581 0.00206680066165107 NA NA NA hsa-miR-182-5p CCND2 5.86988712704738 1.22411588571584e-15 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate;miRTarBase;miRNATAP -0.278474368736704 1.61949004264047e-05 NA NA NA hsa-miR-183-5p CCND2 6.61903249270777 1.00958881445636e-16 -2.81051675901102 0.00139983736368543 miRNATAP -0.288028240113034 1.0097840608077e-06 NA NA NA hsa-miR-191-5p CCND2 1.58824208483839 0.000738859004053681 -2.81051675901102 0.00139983736368543 MirTarget -0.315151097931825 0.00313941450228982 NA NA NA hsa-miR-200a-3p CCND2 6.336081120041 4.024313571871e-16 -2.81051675901102 0.00139983736368543 MirTarget -0.414829241668513 2.52639559759353e-12 NA NA NA hsa-miR-20b-5p CCND2 4.5662923200279 4.75238200639144e-05 -2.81051675901102 0.00139983736368543 miRNATAP -0.295383995634395 4.37719472717441e-12 NA NA NA hsa-miR-224-3p CCND2 2.84876340814503 0.000179138399939161 -2.81051675901102 0.00139983736368543 mirMAP -0.216162489376406 0.00100829595274067 NA NA NA hsa-miR-28-5p CCND2 -0.815636722979196 0.0221199948901761 -2.81051675901102 0.00139983736368543 miRanda -0.428938814049462 0.00272604774130058 NA NA NA hsa-miR-3065-3p CCND2 1.89496019576082 0.0308154823923145 -2.81051675901102 0.00139983736368543 MirTarget;miRNATAP -0.206941274598462 0.000265009133802388 NA NA NA hsa-miR-3065-5p CCND2 2.14185373842821 0.0609400502269891 -2.81051675901102 0.00139983736368543 mirMAP -0.198616424838265 0.000257635954140166 NA NA NA hsa-miR-30d-3p CCND2 -0.0740421896025512 0.857423650167556 -2.81051675901102 0.00139983736368543 mirMAP -0.548341190913964 7.47249707616609e-06 NA NA NA hsa-miR-324-3p CCND2 1.51345381556672 0.0038447546677657 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate -0.43719832262749 4.09891269304966e-06 NA NA NA hsa-miR-33a-3p CCND2 2.06269680799532 0.00156436055383943 -2.81051675901102 0.00139983736368543 MirTarget -0.270924955791957 0.000410846654094401 NA NA NA hsa-miR-378a-3p CCND2 1.46612141870273 0.0466660641196872 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate -0.186901666998984 0.00600686499792038 NA NA NA hsa-miR-429 CCND2 6.39965293994036 1.96920201593608e-18 -2.81051675901102 0.00139983736368543 miRNATAP -0.457780562605429 2.24817157133262e-13 NA NA NA hsa-miR-497-5p CCND2 -1.44150596209372 0.0225146607606395 -2.81051675901102 0.00139983736368543 MirTarget;miRNATAP -0.272420525595686 0.000579324260115001 NA NA NA hsa-miR-550a-5p CCND2 1.21781238856895 0.0613791144699551 -2.81051675901102 0.00139983736368543 MirTarget -0.224646283844048 0.00363403467531415 NA NA NA hsa-miR-660-5p CCND2 -0.0668683798854808 0.885250178390404 -2.81051675901102 0.00139983736368543 mirMAP -0.290960137515711 0.00793054638018279 NA NA NA hsa-miR-9-3p CCND2 1.69328215716742 0.125170982657059 -2.81051675901102 0.00139983736368543 MirTarget;mirMAP;miRNATAP -0.143162485603445 0.00185116011719342 NA NA NA hsa-miR-93-5p CCND2 2.65964181833033 2.58315947526774e-08 -2.81051675901102 0.00139983736368543 miRNATAP -0.48060449639845 2.62594110203289e-06 NA NA NA hsa-miR-96-5p CCND2 5.62521466029286 1.54938806718028e-10 -2.81051675901102 0.00139983736368543 TargetScan;miRNATAP -0.24395409924335 0.000303822796805944 NA NA NA hsa-miR-27b-3p CCND3 -0.0929089601968123 0.85847352206581 -0.53759657598867 0.124370433214632 miRNAWalker2_validate -0.141758210053908 0.000190546260809965 NA NA NA hsa-miR-429 CCND3 6.39965293994036 1.96920201593608e-18 -0.53759657598867 0.124370433214632 miRNATAP -0.112877673525875 7.62633278325715e-06 NA NA NA hsa-miR-96-5p CCND3 5.62521466029286 1.54938806718028e-10 -0.53759657598867 0.124370433214632 TargetScan -0.116905111437921 9.66017245986979e-06 NA NA NA hsa-let-7b-5p CRB2 -0.189422992330471 0.651878220048983 -2.31806879476507 0.0581142170104611 miRNATAP -0.460384715051641 0.0060805026954153 NA NA NA hsa-miR-16-2-3p CTGF 3.79845098071094 1.49120139344659e-13 -4.33545045467629 1.68684819424562e-05 MirTarget -0.739596116076892 1.89677421696511e-12 NA NA NA hsa-miR-18a-5p CTGF 3.90770175770219 9.15298615034137e-10 -4.33545045467629 1.68684819424562e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.473479002391093 4.90104635491302e-08 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling poor survival glioblastoma hsa-miR-19a-3p CTGF 2.17020503944519 0.00122084653711062 -4.33545045467629 1.68684819424562e-05 MirTarget;miRNATAP -0.480864733842777 1.07483303362832e-08 NA NA NA hsa-miR-19b-3p CTGF 1.67581705793313 0.000858910586302716 -4.33545045467629 1.68684819424562e-05 MirTarget;miRNATAP -0.625967163512526 3.01248201266609e-08 NA NA NA hsa-miR-205-5p CTGF 8.08298115900323 3.83045179398654e-07 -4.33545045467629 1.68684819424562e-05 miRNAWalker2_validate;miRTarBase -0.246116307983091 7.1964003979013e-13 NA NA NA hsa-miR-330-3p CTGF 2.49094236945806 0.000129367003214715 -4.33545045467629 1.68684819424562e-05 MirTarget;PITA;miRNATAP -0.26608478138308 0.0026140494750974 NA NA NA hsa-miR-486-5p CTGF 1.10898145177457 0.309287974401609 -4.33545045467629 1.68684819424562e-05 miRanda -0.143227412399099 0.00685905007100677 NA NA NA hsa-miR-590-3p CTGF 2.35429565068338 2.79601879608564e-06 -4.33545045467629 1.68684819424562e-05 PITA;miRanda -0.390815254563478 0.000592418225269412 NA NA NA hsa-miR-140-5p CTNNA1 -0.634610285725923 0.126670572966239 0.139707535094947 0.595525399095619 miRanda -0.129900218211339 0.000287639650973785 NA NA NA hsa-miR-150-5p CTNNB1 1.76769157530064 0.0593795975117846 -0.598740867811971 0.152216124887482 MirTarget -0.1161821301588 2.89988026655084e-06 NA NA NA hsa-miR-155-5p CTNNB1 2.81443182173772 7.42530504828797e-05 -0.598740867811971 0.152216124887482 miRNAWalker2_validate -0.166081896357714 3.05605612118335e-07 NA NA NA hsa-miR-221-3p CTNNB1 0.94082283577318 0.174749164179978 -0.598740867811971 0.152216124887482 miRNAWalker2_validate -0.15386110666748 5.20471332163171e-06 NA NA NA hsa-miR-330-3p CTNNB1 2.49094236945806 0.000129367003214715 -0.598740867811971 0.152216124887482 MirTarget;PITA;miRNATAP -0.113866447624475 0.00159137187547744 NA NA NA hsa-miR-590-3p CTNNB1 2.35429565068338 2.79601879608564e-06 -0.598740867811971 0.152216124887482 miRanda -0.159536768797246 0.00059253265161602 NA NA NA hsa-miR-146b-5p DLG1 1.87569569182453 0.000737241069698886 0.98448076857669 0.0131360102317323 MirTarget;miRanda -0.13958813078163 0.000520113178284264 NA NA NA hsa-miR-186-5p DLG1 0.445443449112564 0.185447310527704 0.98448076857669 0.0131360102317323 MirTarget;mirMAP;miRNATAP -0.245486406317943 0.000316514070999012 NA NA NA hsa-miR-320b DLG1 0.20205459771295 0.727216419960509 0.98448076857669 0.0131360102317323 miRanda -0.104785903485265 0.00731531180080781 NA NA NA hsa-let-7g-3p DLG2 2.09736290930341 5.30067796437833e-05 -4.94038732576826 0.000231772195628754 miRNATAP -0.46190615199696 0.00167315787626089 NA NA NA hsa-miR-130a-3p DLG2 0.176861046122832 0.7577473016872 -4.94038732576826 0.000231772195628754 miRNATAP -0.460977633859174 0.000596649534772148 NA NA NA hsa-miR-130a-5p DLG2 1.58028512890005 0.024346333013728 -4.94038732576826 0.000231772195628754 MirTarget;miRNATAP -0.489841027172739 8.77348479858616e-06 NA NA NA hsa-miR-135b-5p DLG2 4.81084743274382 5.89180530843625e-08 -4.94038732576826 0.000231772195628754 MirTarget -0.42665558683 3.16615458314889e-07 NA NA NA hsa-miR-142-3p DLG2 4.35304505457969 3.10014573651358e-10 -4.94038732576826 0.000231772195628754 miRanda -0.28687631854025 0.00785925695916588 NA NA NA hsa-miR-142-5p DLG2 3.95552531913424 1.49536283724079e-08 -4.94038732576826 0.000231772195628754 PITA;miRNATAP -0.339160576891102 0.00156156609450558 NA NA NA hsa-miR-148b-3p DLG2 1.75622244535669 8.84414356040579e-08 -4.94038732576826 0.000231772195628754 miRNAWalker2_validate;MirTarget -0.970809592406855 3.00176431903323e-05 NA NA NA hsa-miR-148b-5p DLG2 2.80812018666078 3.97536665756679e-08 -4.94038732576826 0.000231772195628754 mirMAP -0.475548993412645 0.00128493576146142 NA NA NA hsa-miR-15b-3p DLG2 3.57530146629867 5.89922785773482e-11 -4.94038732576826 0.000231772195628754 mirMAP -0.70384249364336 1.71095901574137e-07 NA NA NA hsa-miR-16-2-3p DLG2 3.79845098071094 1.49120139344659e-13 -4.94038732576826 0.000231772195628754 mirMAP -0.892716865679819 2.02558563693613e-10 NA NA NA hsa-miR-17-5p DLG2 2.3269271449522 2.13987445663942e-05 -4.94038732576826 0.000231772195628754 mirMAP -0.545326966520393 8.03010427993179e-05 NA NA NA hsa-miR-185-5p DLG2 2.46768243458192 6.53179875424217e-08 -4.94038732576826 0.000231772195628754 MirTarget;miRNATAP -0.619736097137367 0.000176807949764388 NA NA NA hsa-miR-19a-3p DLG2 2.17020503944519 0.00122084653711062 -4.94038732576826 0.000231772195628754 mirMAP -0.353690119822564 0.00186058275464944 NA NA NA hsa-miR-19b-3p DLG2 1.67581705793313 0.000858910586302716 -4.94038732576826 0.000231772195628754 mirMAP -0.510913352024698 0.000793030605347821 NA NA NA hsa-miR-20a-5p DLG2 2.13553469875764 0.000181201072324354 -4.94038732576826 0.000231772195628754 mirMAP -0.385804127998126 0.00394724810709907 NA NA NA hsa-miR-22-5p DLG2 2.38337850108621 1.0773503998394e-05 -4.94038732576826 0.000231772195628754 MirTarget;miRNATAP -0.67363694750017 1.21431462089697e-06 NA NA NA hsa-miR-23a-3p DLG2 0.925125296618358 0.0127293543936914 -4.94038732576826 0.000231772195628754 MirTarget;miRNATAP -0.566237183561861 0.006983932924139 NA NA NA hsa-miR-24-3p DLG2 1.55853749533999 0.000524726461381821 -4.94038732576826 0.000231772195628754 MirTarget -0.546268406892059 0.00139237363158371 NA NA NA hsa-miR-27a-5p DLG2 1.44543293228138 0.039420863458837 -4.94038732576826 0.000231772195628754 miRNATAP -0.464477012717865 1.83368171771657e-05 NA NA NA hsa-miR-29b-1-5p DLG2 0.33698032160171 0.598092174563471 -4.94038732576826 0.000231772195628754 mirMAP -0.369231860316884 0.0022832441671777 NA NA NA hsa-miR-29b-3p DLG2 0.666547117072858 0.234055379278093 -4.94038732576826 0.000231772195628754 MirTarget;miRNATAP -0.490820059595507 0.000349081449300489 NA NA NA hsa-miR-32-3p DLG2 2.20477794939766 0.0392771274032852 -4.94038732576826 0.000231772195628754 mirMAP;miRNATAP -0.458071455506744 0.000277767614488437 NA NA NA hsa-miR-32-5p DLG2 2.93035124381469 5.00149131394151e-10 -4.94038732576826 0.000231772195628754 mirMAP -0.757474095748055 1.54972502963909e-06 NA NA NA hsa-miR-330-3p DLG2 2.49094236945806 0.000129367003214715 -4.94038732576826 0.000231772195628754 PITA;mirMAP -0.419942366688416 0.000329249472480031 NA NA NA hsa-miR-335-3p DLG2 1.19503568251824 0.0938852560631551 -4.94038732576826 0.000231772195628754 mirMAP -0.318496684596031 0.00307253886667102 NA NA NA hsa-miR-338-3p DLG2 0.447551118940466 0.558485097370031 -4.94038732576826 0.000231772195628754 PITA;mirMAP;miRNATAP -0.313272614809971 0.0018013851687342 NA NA NA hsa-miR-33a-3p DLG2 2.06269680799532 0.00156436055383943 -4.94038732576826 0.000231772195628754 MirTarget -0.348731229384826 0.00304680182023013 NA NA NA hsa-miR-33a-5p DLG2 2.60046838991599 0.000472459723448608 -4.94038732576826 0.000231772195628754 mirMAP -0.295640971728406 0.00387966031316372 NA NA NA hsa-miR-33b-5p DLG2 4.77891217497671 1.33695107675057e-08 -4.94038732576826 0.000231772195628754 mirMAP -0.482676782402154 3.9065757171129e-08 NA NA NA hsa-miR-3613-5p DLG2 4.05007522786126 4.52786477176299e-14 -4.94038732576826 0.000231772195628754 MirTarget;miRNATAP -0.434031296817762 0.00158449171488939 NA NA NA hsa-miR-3928-3p DLG2 0.496945216853306 0.488043119673691 -4.94038732576826 0.000231772195628754 MirTarget -0.293273368610486 0.00755572725080333 NA NA NA hsa-miR-484 DLG2 1.79050445056016 0.000217287101253701 -4.94038732576826 0.000231772195628754 MirTarget;PITA -0.653577563787161 3.20882988366295e-05 NA NA NA hsa-miR-582-5p DLG2 0.685177900016753 0.447761540297692 -4.94038732576826 0.000231772195628754 PITA -0.268510529593978 0.00156328696249142 NA NA NA hsa-miR-590-3p DLG2 2.35429565068338 2.79601879608564e-06 -4.94038732576826 0.000231772195628754 PITA;miRanda;mirMAP -0.396975941883599 0.00881568838215839 NA NA NA hsa-miR-590-5p DLG2 1.51400888103768 0.0023888567923017 -4.94038732576826 0.000231772195628754 PITA;miRanda -0.550902740600919 0.000336545621128562 NA NA NA hsa-miR-628-3p DLG2 1.25836654921842 0.122809788039323 -4.94038732576826 0.000231772195628754 PITA;mirMAP -0.364922106814027 0.000131532342102651 NA NA NA hsa-miR-642a-5p DLG2 3.38585273752088 0.000272015814573312 -4.94038732576826 0.000231772195628754 MirTarget -0.274322127089122 0.00700963218887338 NA NA NA hsa-miR-769-3p DLG2 1.74947739956763 0.0310790621215023 -4.94038732576826 0.000231772195628754 PITA;miRNATAP -0.329980074748954 0.00439135069075151 NA NA NA hsa-miR-877-5p DLG2 3.67317721493893 4.85916829184578e-06 -4.94038732576826 0.000231772195628754 MirTarget -0.486716769562 2.03186545547954e-07 NA NA NA hsa-miR-92a-3p DLG2 1.87892405805529 1.27013821556583e-05 -4.94038732576826 0.000231772195628754 mirMAP -0.758309641725803 1.73598834621965e-05 NA NA NA hsa-miR-92b-3p DLG2 1.69303761469782 0.0103484911955574 -4.94038732576826 0.000231772195628754 mirMAP -0.457519776492294 7.28718129432529e-05 NA NA NA hsa-miR-93-3p DLG2 2.62833115374128 2.28843227834337e-07 -4.94038732576826 0.000231772195628754 MirTarget;miRNATAP -0.422027754062414 0.0046675430404058 NA NA NA hsa-miR-944 DLG2 7.20925181386398 0.000823207457340648 -4.94038732576826 0.000231772195628754 PITA;mirMAP;miRNATAP -0.155024637185826 0.000392736810652093 NA NA NA hsa-miR-330-5p DLG3 2.25110496739954 0.000275527655397415 0.713304510442303 0.0863216160064924 miRanda;miRNATAP -0.103116974473111 0.00632507267374824 NA NA NA hsa-miR-342-3p DLG3 1.31107714473009 0.0207211910724662 0.713304510442303 0.0863216160064924 miRanda -0.147597901930126 0.000362280416862032 NA NA NA hsa-miR-10a-5p DVL1 -0.482300926520507 0.594608783320466 0.0930830936484925 0.802605048970877 miRNAWalker2_validate -0.11026504710669 1.40870159993299e-06 NA NA NA hsa-miR-125a-5p DVL3 -1.32352790615388 0.00714301627309467 0.712696667163076 0.0441831929271895 PITA -0.114291084779072 0.00510375398533769 NA NA NA hsa-miR-146b-3p DVL3 1.34608871980101 0.00935728391852709 0.712696667163076 0.0441831929271895 MirTarget -0.152558917031062 7.36274039601236e-05 NA NA NA hsa-miR-29b-2-5p DVL3 -0.596051745078872 0.189540844841389 0.712696667163076 0.0441831929271895 MirTarget -0.119308522306106 0.00736926175410278 NA NA NA hsa-miR-30a-3p DVL3 -1.22212086897848 0.167565797592104 0.712696667163076 0.0441831929271895 MirTarget -0.122406816743673 3.30206813290696e-08 NA NA NA hsa-miR-148b-3p FBXW11 1.75622244535669 8.84414356040579e-08 -0.558881503264246 0.0547787087394548 miRNAWalker2_validate -0.137834010500419 0.00589089218467001 NA NA NA hsa-miR-331-3p FBXW11 2.60769294751513 3.84318952029483e-07 -0.558881503264246 0.0547787087394548 miRNATAP -0.103415497025069 0.00100190758728944 NA NA NA hsa-miR-374b-5p FBXW11 -0.114749866169918 0.764888930049438 -0.558881503264246 0.0547787087394548 mirMAP -0.131824038103188 0.00241540705330138 NA NA NA hsa-miR-590-3p FBXW11 2.35429565068338 2.79601879608564e-06 -0.558881503264246 0.0547787087394548 mirMAP -0.101190816629317 0.00171731927469691 NA NA NA hsa-miR-186-5p FGF1 0.445443449112564 0.185447310527704 -0.904800782358151 0.37514033641596 mirMAP -0.498564513948469 0.00456225800988677 NA NA NA hsa-miR-18a-5p FGF1 3.90770175770219 9.15298615034137e-10 -0.904800782358151 0.37514033641596 MirTarget -0.41163099594303 2.32644463832958e-06 NA NA NA hsa-miR-330-5p FGF1 2.25110496739954 0.000275527655397415 -0.904800782358151 0.37514033641596 miRanda;miRNATAP -0.300815609641433 0.00115338039105615 NA NA NA hsa-miR-429 FGF1 6.39965293994036 1.96920201593608e-18 -0.904800782358151 0.37514033641596 miRNATAP -0.277552339482351 0.000183037961286987 NA NA NA hsa-miR-484 FGF1 1.79050445056016 0.000217287101253701 -0.904800782358151 0.37514033641596 MirTarget;PITA;miRNATAP -0.634998887940648 5.85563813084433e-08 NA NA NA hsa-miR-532-3p FGF1 0.643755490841218 0.214842585969913 -0.904800782358151 0.37514033641596 miRNATAP -0.387150102032302 0.000527239876040661 NA NA NA hsa-miR-550a-5p FGF1 1.21781238856895 0.0613791144699551 -0.904800782358151 0.37514033641596 MirTarget -0.314103791160951 0.000393501674872474 NA NA NA hsa-miR-576-5p FGF1 1.30320223793746 0.00648929463912994 -0.904800782358151 0.37514033641596 PITA;mirMAP -0.327654055057913 0.00686443176136871 NA NA NA hsa-miR-590-5p FGF1 1.51400888103768 0.0023888567923017 -0.904800782358151 0.37514033641596 MirTarget;miRanda;miRNATAP -0.451620799574134 9.03523892284351e-05 NA NA NA hsa-miR-7-5p FGF1 3.59831747997243 0.000676336260217879 -0.904800782358151 0.37514033641596 miRNAWalker2_validate -0.227873135380002 0.000618398446708633 NA NA NA hsa-miR-106a-5p FRMD6 3.98693608217557 9.37722470816656e-07 -1.60821237953985 0.0820702410760675 MirTarget;miRNATAP -0.395774815873129 1.3921524371428e-10 NA NA NA hsa-miR-106b-5p FRMD6 2.80565545918114 1.14547999022566e-09 -1.60821237953985 0.0820702410760675 MirTarget;miRNATAP -0.432984917327778 9.61909894505862e-05 NA NA NA hsa-miR-125a-3p FRMD6 -0.0748960586927341 0.920735897434087 -1.60821237953985 0.0820702410760675 MirTarget;miRanda -0.195671325219018 0.00514337440300257 NA NA NA hsa-miR-130b-3p FRMD6 3.9204771543282 1.2714917955808e-11 -1.60821237953985 0.0820702410760675 MirTarget -0.266784869424662 0.00235671114898859 NA NA NA hsa-miR-141-3p FRMD6 7.30474126597325 1.45115996357606e-24 -1.60821237953985 0.0820702410760675 MirTarget;TargetScan;miRNATAP -0.344768295051833 2.45271585321807e-07 NA NA NA hsa-miR-183-5p FRMD6 6.61903249270777 1.00958881445636e-16 -1.60821237953985 0.0820702410760675 MirTarget;miRNATAP -0.197506171970031 0.00151448894574695 NA NA NA hsa-miR-200a-3p FRMD6 6.336081120041 4.024313571871e-16 -1.60821237953985 0.0820702410760675 MirTarget;miRNATAP -0.465768544055995 3.72368449094804e-14 NA NA NA hsa-miR-200b-3p FRMD6 5.56167217794639 6.43540045061709e-16 -1.60821237953985 0.0820702410760675 TargetScan -0.509028109042186 3.51494686896629e-13 NA NA NA hsa-miR-200c-3p FRMD6 6.47012025883743 2.64500707716408e-26 -1.60821237953985 0.0820702410760675 miRNATAP -0.318497228385608 5.01705490615743e-05 NA NA NA hsa-miR-20b-5p FRMD6 4.5662923200279 4.75238200639144e-05 -1.60821237953985 0.0820702410760675 MirTarget;miRNATAP -0.284829571452508 2.17026377351647e-10 NA NA NA hsa-miR-29b-2-5p FRMD6 -0.596051745078872 0.189540844841389 -1.60821237953985 0.0820702410760675 MirTarget -0.761783404380426 1.70255796027634e-11 NA NA NA hsa-miR-301a-3p FRMD6 1.99338115332667 0.000813358604963724 -1.60821237953985 0.0820702410760675 MirTarget -0.281864714109493 0.00129042083900767 NA NA NA hsa-miR-30a-5p FRMD6 -0.768430903969183 0.320487552854215 -1.60821237953985 0.0820702410760675 MirTarget;miRNATAP -0.469159533154628 8.18180975475182e-13 NA NA NA hsa-miR-30b-5p FRMD6 0.0238659735605804 0.953223658270319 -1.60821237953985 0.0820702410760675 MirTarget -0.463107399421934 0.000385726095612629 NA NA NA hsa-miR-30c-5p FRMD6 0.38723991118075 0.348605235643473 -1.60821237953985 0.0820702410760675 MirTarget;miRNATAP -0.455911891218759 0.000380450258001239 NA NA NA hsa-miR-30d-5p FRMD6 0.302504510257496 0.380193536606962 -1.60821237953985 0.0820702410760675 MirTarget;miRNATAP -0.656979801507581 2.09307357211567e-05 NA NA NA hsa-miR-30e-5p FRMD6 0.780047227271616 0.0346714425913016 -1.60821237953985 0.0820702410760675 MirTarget -0.402854338691065 0.00526358583073859 NA NA NA hsa-miR-335-3p FRMD6 1.19503568251824 0.0938852560631551 -1.60821237953985 0.0820702410760675 mirMAP -0.200932122523329 0.00631233107023157 NA NA NA hsa-miR-3613-5p FRMD6 4.05007522786126 4.52786477176299e-14 -1.60821237953985 0.0820702410760675 miRNATAP -0.310664732383297 0.000925032805620646 NA NA NA hsa-miR-362-3p FRMD6 0.679952485897744 0.226148468488576 -1.60821237953985 0.0820702410760675 miRanda;miRNATAP -0.335929248735904 0.000341090457266929 NA NA NA hsa-miR-375 FRMD6 3.3784490463318 0.0449946294355695 -1.60821237953985 0.0820702410760675 miRanda -0.299299637839527 1.01574435880884e-25 NA NA NA hsa-miR-429 FRMD6 6.39965293994036 1.96920201593608e-18 -1.60821237953985 0.0820702410760675 miRanda;miRNATAP -0.437627088650485 2.81156339495184e-11 NA NA NA hsa-miR-454-3p FRMD6 1.40269869979902 0.00366085847011367 -1.60821237953985 0.0820702410760675 MirTarget -0.405965575930722 0.000181889679560702 NA NA NA hsa-miR-501-5p FRMD6 1.0411896821345 0.0777206709183552 -1.60821237953985 0.0820702410760675 MirTarget;PITA;miRNATAP -0.317354117611165 0.000350293585620098 NA NA NA hsa-miR-671-5p FRMD6 1.48527046124636 0.00686722328347111 -1.60821237953985 0.0820702410760675 MirTarget -0.314979768727799 0.000950762674481901 NA NA NA hsa-miR-7-1-3p FRMD6 1.43074343339835 0.00471215970502094 -1.60821237953985 0.0820702410760675 MirTarget -0.33022897862505 0.0014417165649963 NA NA NA hsa-miR-93-5p FRMD6 2.65964181833033 2.58315947526774e-08 -1.60821237953985 0.0820702410760675 MirTarget;miRNATAP -0.310562093033508 0.00407961862361979 NA NA NA hsa-miR-146b-5p FZD1 1.87569569182453 0.000737241069698886 -0.318491374654607 0.491789959368398 MirTarget;PITA;miRanda -0.12122238704442 0.00988542294343242 NA NA NA hsa-miR-29a-3p FZD1 -0.638239697975974 0.251923581881716 -0.318491374654607 0.491789959368398 mirMAP -0.171333710769929 0.00026723836872456 NA NA NA hsa-miR-29b-3p FZD1 0.666547117072858 0.234055379278093 -0.318491374654607 0.491789959368398 mirMAP -0.223781902211902 1.38655813660173e-06 NA NA NA hsa-miR-590-3p FZD1 2.35429565068338 2.79601879608564e-06 -0.318491374654607 0.491789959368398 miRanda -0.178450935504682 0.000518778693117224 NA NA NA hsa-miR-335-5p FZD10 0.167216045757305 0.803897055331049 0.817127632737711 0.546902427216764 miRNAWalker2_validate -0.32447150664636 0.0045590174989641 NA NA NA hsa-miR-92b-3p FZD10 1.69303761469782 0.0103484911955574 0.817127632737711 0.546902427216764 miRNATAP -0.408813919349178 0.000408188212271156 NA NA NA hsa-let-7b-3p FZD3 0.589364128513318 0.200507534602851 -2.2712968833062 0.0197819973302092 MirTarget;miRNATAP -0.391775229422405 0.00123397253469845 NA NA NA hsa-let-7b-5p FZD3 -0.189422992330471 0.651878220048983 -2.2712968833062 0.0197819973302092 MirTarget;miRNATAP -0.400834438580578 0.00271706179103384 NA NA NA hsa-let-7f-1-3p FZD3 1.61507869803314 0.00069342464777815 -2.2712968833062 0.0197819973302092 MirTarget -0.31298120278851 0.00751255516333369 NA NA NA hsa-miR-142-3p FZD3 4.35304505457969 3.10014573651358e-10 -2.2712968833062 0.0197819973302092 miRanda -0.335676063800471 1.33860192234743e-05 NA NA NA hsa-miR-146a-5p FZD3 2.64646698525354 0.000280611928973036 -2.2712968833062 0.0197819973302092 MirTarget -0.373068677777254 5.20415294434459e-07 NA NA NA hsa-miR-155-5p FZD3 2.81443182173772 7.42530504828797e-05 -2.2712968833062 0.0197819973302092 mirMAP -0.359934463087244 2.38470974855901e-06 NA NA NA hsa-miR-16-1-3p FZD3 2.83281226969693 7.54359864580834e-09 -2.2712968833062 0.0197819973302092 mirMAP -0.319820172643704 0.00394897878069372 NA NA NA hsa-miR-16-2-3p FZD3 3.79845098071094 1.49120139344659e-13 -2.2712968833062 0.0197819973302092 mirMAP -0.313624624836376 0.00252529278231522 NA NA NA hsa-miR-205-5p FZD3 8.08298115900323 3.83045179398654e-07 -2.2712968833062 0.0197819973302092 MirTarget -0.168834170318472 4.72789797910524e-07 25521201 Our data analysis also showed that miR-98 and miR-205 have two common predicted target genes FZD3 and RPS6KA3 which are actually genes associated with carcinoma according to the Online Mendelian Inheritance in Man OMIM database lung squamous cell cancer hsa-miR-23b-3p FZD3 -0.581135273821923 0.190478897170459 -2.2712968833062 0.0197819973302092 MirTarget -0.421924654848594 0.000798515248907007 NA NA NA hsa-miR-27b-3p FZD3 -0.0929089601968123 0.85847352206581 -2.2712968833062 0.0197819973302092 miRNATAP -0.372976594023668 0.000477589576040137 NA NA NA hsa-miR-342-3p FZD3 1.31107714473009 0.0207211910724662 -2.2712968833062 0.0197819973302092 miRanda -0.295682048421979 0.00249712798748224 NA NA NA hsa-miR-452-3p FZD3 2.97956996345436 0.000203580834647624 -2.2712968833062 0.0197819973302092 MirTarget -0.222632262971689 0.00114068931063861 NA NA NA hsa-miR-452-5p FZD3 2.45466810475361 0.00114794259949532 -2.2712968833062 0.0197819973302092 mirMAP -0.327172010172874 5.73268775022015e-06 NA NA NA hsa-miR-944 FZD3 7.20925181386398 0.000823207457340648 -2.2712968833062 0.0197819973302092 MirTarget;PITA;miRNATAP -0.201675798691389 5.69788087904236e-11 NA NA NA hsa-let-7a-3p FZD4 0.82512001802525 0.0468122405194487 -2.83886953461754 3.72732903465121e-05 mirMAP -0.289191281655542 0.00261784404358226 NA NA NA hsa-let-7b-3p FZD4 0.589364128513318 0.200507534602851 -2.83886953461754 3.72732903465121e-05 mirMAP -0.229269440598043 0.00813497276382615 NA NA NA hsa-let-7b-5p FZD4 -0.189422992330471 0.651878220048983 -2.83886953461754 3.72732903465121e-05 MirTarget;miRNATAP -0.275360310596682 0.00386154408558111 NA NA NA hsa-let-7f-1-3p FZD4 1.61507869803314 0.00069342464777815 -2.83886953461754 3.72732903465121e-05 mirMAP -0.271909202878902 0.00107897881690323 NA NA NA hsa-miR-141-3p FZD4 7.30474126597325 1.45115996357606e-24 -2.83886953461754 3.72732903465121e-05 TargetScan -0.146207262935211 0.00415064235917507 NA NA NA hsa-miR-150-5p FZD4 1.76769157530064 0.0593795975117846 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.131035747829938 0.00176171330583994 NA NA NA hsa-miR-15b-5p FZD4 3.32329949959268 8.40210501034588e-13 -2.83886953461754 3.72732903465121e-05 MirTarget -0.282999459031275 0.000569874909623984 NA NA NA hsa-miR-16-5p FZD4 2.93575808220754 2.15436817162977e-10 -2.83886953461754 3.72732903465121e-05 MirTarget -0.227505888117745 0.00647410235924482 NA NA NA hsa-miR-200b-3p FZD4 5.56167217794639 6.43540045061709e-16 -2.83886953461754 3.72732903465121e-05 mirMAP -0.238298937559481 1.05112124811421e-05 NA NA NA hsa-miR-200c-3p FZD4 6.47012025883743 2.64500707716408e-26 -2.83886953461754 3.72732903465121e-05 mirMAP -0.233220034337669 8.01322431715165e-05 NA NA NA hsa-miR-224-3p FZD4 2.84876340814503 0.000179138399939161 -2.83886953461754 3.72732903465121e-05 MirTarget -0.28225814299032 2.87859841920122e-08 NA NA NA hsa-miR-25-3p FZD4 1.12623030168869 0.00311079344417173 -2.83886953461754 3.72732903465121e-05 mirMAP -0.316761893783551 0.00247147999129914 NA NA NA hsa-miR-27a-3p FZD4 1.76094007417453 0.000216137556256765 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.261515033149759 0.00156287118774928 NA NA NA hsa-miR-27b-3p FZD4 -0.0929089601968123 0.85847352206581 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.243490119104825 0.0013959995389089 NA NA NA hsa-miR-33a-3p FZD4 2.06269680799532 0.00156436055383943 -2.83886953461754 3.72732903465121e-05 mirMAP -0.315492579937533 1.17062941143373e-07 NA NA NA hsa-miR-429 FZD4 6.39965293994036 1.96920201593608e-18 -2.83886953461754 3.72732903465121e-05 mirMAP -0.223467585312549 9.44591820899412e-06 NA NA NA hsa-miR-452-5p FZD4 2.45466810475361 0.00114794259949532 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.314911211799412 5.04643655024212e-10 NA NA NA hsa-miR-576-5p FZD4 1.30320223793746 0.00648929463912994 -2.83886953461754 3.72732903465121e-05 mirMAP -0.216830219353013 0.00885127918136263 NA NA NA hsa-miR-590-3p FZD4 2.35429565068338 2.79601879608564e-06 -2.83886953461754 3.72732903465121e-05 miRanda;mirMAP;miRNATAP -0.229697889158717 0.00314265095609673 NA NA NA hsa-miR-629-3p FZD4 3.48282157979573 4.9176538695908e-08 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.227018116324061 0.00016531596497597 NA NA NA hsa-miR-653-5p FZD4 1.43354001460259 0.0479177174923075 -2.83886953461754 3.72732903465121e-05 MirTarget -0.16470578851558 0.0027849753448391 NA NA NA hsa-miR-708-5p FZD4 1.70409736218557 0.0319538709865338 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.193141187540541 8.78652560864314e-05 NA NA NA hsa-let-7b-3p FZD5 0.589364128513318 0.200507534602851 0.640287282353737 0.297444783437361 miRNATAP -0.205895528602781 0.00696500873050967 NA NA NA hsa-miR-155-5p FZD5 2.81443182173772 7.42530504828797e-05 0.640287282353737 0.297444783437361 miRNATAP -0.211896725721244 1.00818321655591e-05 NA NA NA hsa-miR-23a-3p FZD5 0.925125296618358 0.0127293543936914 0.640287282353737 0.297444783437361 miRNATAP -0.289711657168532 0.00225871469675491 NA NA NA hsa-miR-23b-3p FZD5 -0.581135273821923 0.190478897170459 0.640287282353737 0.297444783437361 miRNATAP -0.280347016349859 0.000379321134775307 NA NA NA hsa-miR-24-3p FZD5 1.55853749533999 0.000524726461381821 0.640287282353737 0.297444783437361 miRNAWalker2_validate;miRNATAP -0.22875330448975 0.00314726074883253 NA NA NA hsa-miR-342-3p FZD5 1.31107714473009 0.0207211910724662 0.640287282353737 0.297444783437361 PITA -0.186426276738242 0.0023834988286169 NA NA NA hsa-miR-99a-5p FZD5 -2.72139054000803 0.00621971944534118 0.640287282353737 0.297444783437361 MirTarget;miRNATAP -0.125875532977723 0.000270995390359697 NA NA NA hsa-miR-194-5p FZD6 0.691219038144468 0.523143086635506 1.58130849246817 0.00919065409091848 MirTarget -0.251019560286905 1.22839454916662e-16 NA NA NA hsa-miR-142-3p FZD7 4.35304505457969 3.10014573651358e-10 -2.72325006685666 0.00150687292014913 miRanda -0.373560938656454 3.11438751908879e-08 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7; In addition we demonstrated that FZD7 was a direct target of miR-142-3p by dual luciferase assay and Western blot analysis; Overexpression of FZD7 expression was able to reverse the inhibitory effects induced by miR-142-3p cervical and endocervical cancer hsa-miR-142-5p FZD7 3.95552531913424 1.49536283724079e-08 -2.72325006685666 0.00150687292014913 MirTarget;PITA;miRNATAP -0.362955447075897 6.92115542119614e-08 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7 cervical and endocervical cancer hsa-miR-192-5p FZD7 1.77716187978541 0.113485496183047 -2.72325006685666 0.00150687292014913 miRNAWalker2_validate -0.115148199976731 0.00808053119326572 NA NA NA hsa-miR-215-5p FZD7 3.66990923176752 0.00294614570694381 -2.72325006685666 0.00150687292014913 miRNAWalker2_validate -0.128832283203823 0.00103711067552621 NA NA NA hsa-miR-330-3p FZD7 2.49094236945806 0.000129367003214715 -2.72325006685666 0.00150687292014913 mirMAP -0.278992643858465 0.000179188356936391 NA NA NA hsa-miR-338-5p FZD7 -0.108304629897487 0.894675560494607 -2.72325006685666 0.00150687292014913 MirTarget;PITA;miRNATAP -0.165566070058614 0.00594825069199063 NA NA NA hsa-miR-590-3p FZD7 2.35429565068338 2.79601879608564e-06 -2.72325006685666 0.00150687292014913 miRanda -0.403041157541026 2.56570813299877e-05 NA NA NA hsa-miR-590-3p FZD8 2.35429565068338 2.79601879608564e-06 -0.605760786756907 0.557609369330486 miRanda -0.346881927689195 0.00260365350935014 NA NA NA hsa-miR-192-5p FZD9 1.77716187978541 0.113485496183047 0.892340449420943 0.433615785945545 miRNATAP -0.269388155649398 1.93576138120715e-06 NA NA NA hsa-let-7g-5p GDF6 0.857251702023746 0.00647597344297273 -1.55269438174044 0.352529357077876 MirTarget;miRNATAP -0.899439728625514 0.00341856573105334 NA NA NA hsa-miR-200b-3p GDF6 5.56167217794639 6.43540045061709e-16 -1.55269438174044 0.352529357077876 TargetScan -0.609131046562882 2.49506902870059e-06 NA NA NA hsa-miR-3607-3p GDF6 1.38015131722213 0.0240067155694847 -1.55269438174044 0.352529357077876 MirTarget;miRNATAP -0.400439942474613 0.00976032234657523 NA NA NA hsa-miR-429 GDF6 6.39965293994036 1.96920201593608e-18 -1.55269438174044 0.352529357077876 PITA;miRanda;miRNATAP -0.536897304948851 9.0270313133678e-06 NA NA NA hsa-miR-532-3p GDF6 0.643755490841218 0.214842585969913 -1.55269438174044 0.352529357077876 PITA;miRNATAP -0.59653841850623 0.00112382468971625 NA NA NA hsa-miR-141-3p GLI2 7.30474126597325 1.45115996357606e-24 -3.16034565720973 0.00803297030667213 MirTarget -0.269236432473808 0.00212225167864674 NA NA NA hsa-miR-142-3p GLI2 4.35304505457969 3.10014573651358e-10 -3.16034565720973 0.00803297030667213 miRanda -0.386279401610553 4.47352767240335e-05 NA NA NA hsa-miR-30e-5p GLI2 0.780047227271616 0.0346714425913016 -3.16034565720973 0.00803297030667213 MirTarget -0.804794199077447 1.37362126753449e-05 NA NA NA hsa-miR-330-5p GLI2 2.25110496739954 0.000275527655397415 -3.16034565720973 0.00803297030667213 MirTarget -0.340516857599761 0.00174950588232576 NA NA NA hsa-miR-181c-5p GSK3B -0.302833440762172 0.537532549455539 0.984264794042029 0.00614784819440891 mirMAP -0.115369483842179 0.00582165998524454 NA NA NA hsa-miR-30a-3p GSK3B -1.22212086897848 0.167565797592104 0.984264794042029 0.00614784819440891 miRNATAP -0.11517576765646 3.57050461951731e-07 NA NA NA hsa-miR-30d-3p GSK3B -0.0740421896025512 0.857423650167556 0.984264794042029 0.00614784819440891 miRNATAP -0.217356687168476 1.21966436788369e-05 NA NA NA hsa-miR-320c GSK3B -0.10618808730545 0.854002814666472 0.984264794042029 0.00614784819440891 miRanda;mirMAP -0.100605875350465 0.00537879672016752 NA NA NA hsa-miR-362-5p GSK3B -1.22309034685697 0.0452665543907975 0.984264794042029 0.00614784819440891 miRNATAP -0.116235509089146 0.000473661337943669 NA NA NA hsa-miR-192-5p ID1 1.77716187978541 0.113485496183047 0.324775311059279 0.675429586210614 miRNAWalker2_validate -0.136145277295878 0.000450814998396788 NA NA NA hsa-let-7a-3p ID2 0.82512001802525 0.0468122405194487 -1.44903761787758 0.028108297351186 miRNATAP -0.332304595270933 0.000255934152081128 NA NA NA hsa-miR-139-5p ID2 -2.09475477693654 0.000382570602748311 -1.44903761787758 0.028108297351186 miRanda -0.170162907716332 0.00711830840129372 NA NA NA hsa-miR-27a-3p ID2 1.76094007417453 0.000216137556256765 -1.44903761787758 0.028108297351186 MirTarget;miRNATAP -0.360335443916806 3.57937005002133e-06 NA NA NA hsa-miR-330-3p ID2 2.49094236945806 0.000129367003214715 -1.44903761787758 0.028108297351186 MirTarget;PITA;miRNATAP -0.211998117870452 0.000199415670908787 NA NA NA hsa-miR-335-3p ID2 1.19503568251824 0.0938852560631551 -1.44903761787758 0.028108297351186 MirTarget -0.185872652315649 0.000380455687029298 NA NA NA hsa-miR-455-3p ID2 2.1864857056272 0.00137304627957677 -1.44903761787758 0.028108297351186 MirTarget;PITA;miRNATAP -0.159086590304116 0.003512126153271 NA NA NA hsa-miR-125a-5p ITGB2 -1.32352790615388 0.00714301627309467 0.908713576834828 0.246356918979977 miRanda -0.241340017714659 0.00771573998304893 NA NA NA hsa-miR-335-5p ITGB2 0.167216045757305 0.803897055331049 0.908713576834828 0.246356918979977 miRNAWalker2_validate -0.25170697663495 0.000129167958455537 NA NA NA hsa-miR-429 ITGB2 6.39965293994036 1.96920201593608e-18 0.908713576834828 0.246356918979977 miRanda -0.273005565283884 1.39604535248538e-06 NA NA NA hsa-let-7a-3p LATS1 0.82512001802525 0.0468122405194487 0.0987378692417358 0.879011295890161 MirTarget;mirMAP -0.243322928311961 0.00650143551968156 NA NA NA hsa-miR-142-3p LATS1 4.35304505457969 3.10014573651358e-10 0.0987378692417358 0.879011295890161 MirTarget -0.147005456469228 0.00430417688581722 NA NA NA hsa-miR-16-2-3p LATS1 3.79845098071094 1.49120139344659e-13 0.0987378692417358 0.879011295890161 mirMAP -0.192848245484757 0.00507174614571916 NA NA NA hsa-miR-193a-3p LATS1 0.646392169474854 0.207134343676122 0.0987378692417358 0.879011295890161 miRanda -0.231996291647244 0.0012565413782778 NA NA NA hsa-miR-29a-5p LATS1 0.0748295222568571 0.884125894063293 0.0987378692417358 0.879011295890161 MirTarget -0.298906445256695 2.87343464473153e-05 NA NA NA hsa-miR-3607-3p LATS1 1.38015131722213 0.0240067155694847 0.0987378692417358 0.879011295890161 MirTarget -0.238746919174766 6.18555540410703e-05 NA NA NA hsa-miR-374b-5p LATS1 -0.114749866169918 0.764888930049438 0.0987378692417358 0.879011295890161 mirMAP -0.291268092033396 0.00273654663789176 NA NA NA hsa-miR-590-3p LATS1 2.35429565068338 2.79601879608564e-06 0.0987378692417358 0.879011295890161 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.254539123275836 0.000410894819624842 NA NA NA hsa-miR-130b-5p LATS2 3.74118449312296 2.92266550966038e-10 -1.64065240798514 0.000675576860801643 miRNATAP -0.207124300643863 3.44462063930965e-06 NA NA NA hsa-miR-15b-5p LATS2 3.32329949959268 8.40210501034588e-13 -1.64065240798514 0.000675576860801643 miRNATAP -0.202584110889233 0.000399028596231128 NA NA NA hsa-miR-188-5p LATS2 1.39111178824125 0.0251592818948912 -1.64065240798514 0.000675576860801643 PITA -0.185050030245761 2.77697064486261e-05 NA NA NA hsa-miR-200b-3p LATS2 5.56167217794639 6.43540045061709e-16 -1.64065240798514 0.000675576860801643 TargetScan -0.240613824540664 7.94624921697158e-11 NA NA NA hsa-miR-200c-3p LATS2 6.47012025883743 2.64500707716408e-26 -1.64065240798514 0.000675576860801643 miRNATAP -0.142079684531404 0.000588434621432939 NA NA NA hsa-miR-25-3p LATS2 1.12623030168869 0.00311079344417173 -1.64065240798514 0.000675576860801643 miRNATAP -0.440885875249659 6.09609115448906e-10 25179841 MiR 25 promotes ovarian cancer proliferation and motility by targeting LATS2; Large tumor suppressor 2 LATS2 a tumor suppressor was confirmed to be a direct target of miR-25 in OC cells; Moreover restoration of LATS2 significantly attenuated the oncogenic effects of miR-25 motility ovarian cancer hsa-miR-33a-3p LATS2 2.06269680799532 0.00156436055383943 -1.64065240798514 0.000675576860801643 mirMAP -0.225092070326382 5.65308152455292e-08 NA NA NA hsa-miR-342-3p LATS2 1.31107714473009 0.0207211910724662 -1.64065240798514 0.000675576860801643 PITA;miRanda -0.129171442682311 0.00791780417271905 NA NA NA hsa-miR-361-5p LATS2 0.00649167180664723 0.985202350239079 -1.64065240798514 0.000675576860801643 miRanda -0.35279950739997 9.39137499171822e-06 NA NA NA hsa-miR-362-3p LATS2 0.679952485897744 0.226148468488576 -1.64065240798514 0.000675576860801643 PITA;miRanda -0.222310110621702 5.37205167825397e-06 NA NA NA hsa-miR-374a-5p LATS2 0.278549982012055 0.45888283715888 -1.64065240798514 0.000675576860801643 mirMAP -0.273089910100329 0.000231386788574509 NA NA NA hsa-miR-374b-5p LATS2 -0.114749866169918 0.764888930049438 -1.64065240798514 0.000675576860801643 mirMAP -0.287078545483899 7.55914502218416e-05 NA NA NA hsa-miR-429 LATS2 6.39965293994036 1.96920201593608e-18 -1.64065240798514 0.000675576860801643 PITA;miRanda;miRNATAP -0.213243819355158 7.55394686480351e-10 NA NA NA hsa-miR-590-3p LATS2 2.35429565068338 2.79601879608564e-06 -1.64065240798514 0.000675576860801643 PITA;miRanda -0.18564682796804 0.000596216790630487 NA NA NA hsa-miR-93-5p LATS2 2.65964181833033 2.58315947526774e-08 -1.64065240798514 0.000675576860801643 miRNAWalker2_validate -0.236611247784225 2.60971836347712e-05 NA NA NA hsa-miR-96-5p LATS2 5.62521466029286 1.54938806718028e-10 -1.64065240798514 0.000675576860801643 miRNATAP -0.119887334412182 0.00123015905839541 NA NA NA hsa-miR-193b-3p LEF1 1.35015762547152 0.0874921379319504 -1.06801208642423 0.21098542163647 miRNAWalker2_validate -0.349322384823671 5.36528724241979e-09 NA NA NA hsa-miR-330-5p LEF1 2.25110496739954 0.000275527655397415 -1.06801208642423 0.21098542163647 miRanda -0.403439067915215 1.29300750911004e-07 NA NA NA hsa-miR-143-3p LIMD1 -2.63566161228438 9.50531786970839e-05 0.423889857658594 0.253280813701185 mirMAP -0.109432550629521 0.00034594408011487 NA NA NA hsa-miR-155-5p LIMD1 2.81443182173772 7.42530504828797e-05 0.423889857658594 0.253280813701185 mirMAP -0.12449190404845 1.66234029677186e-05 NA NA NA hsa-miR-2355-5p LIMD1 0.418226038913005 0.502149040287915 0.423889857658594 0.253280813701185 mirMAP -0.120307561848768 0.000340008063939735 NA NA NA hsa-miR-23a-3p LIMD1 0.925125296618358 0.0127293543936914 0.423889857658594 0.253280813701185 mirMAP -0.199717974480413 0.000455427143743097 NA NA NA hsa-miR-23b-3p LIMD1 -0.581135273821923 0.190478897170459 0.423889857658594 0.253280813701185 mirMAP -0.151589452207742 0.00144254778594273 NA NA NA hsa-miR-24-3p LIMD1 1.55853749533999 0.000524726461381821 0.423889857658594 0.253280813701185 miRNAWalker2_validate;MirTarget -0.143142332556087 0.00213076136620691 NA NA NA hsa-miR-30e-3p LIMD1 -0.0362193022195196 0.932577027239525 0.423889857658594 0.253280813701185 mirMAP -0.171366576624664 0.000521166007159347 NA NA NA hsa-miR-342-3p LIMD1 1.31107714473009 0.0207211910724662 0.423889857658594 0.253280813701185 MirTarget;miRanda -0.103826160348476 0.00499499162598616 NA NA NA hsa-miR-455-3p LIMD1 2.1864857056272 0.00137304627957677 0.423889857658594 0.253280813701185 miRNAWalker2_validate;mirMAP -0.118781635845878 8.76524847331297e-05 NA NA NA hsa-miR-590-3p MPP5 2.35429565068338 2.79601879608564e-06 0.714055716737682 0.0194499835112981 MirTarget;PITA;miRanda;miRNATAP -0.105885387991252 0.00182769286438342 NA NA NA hsa-miR-34a-5p MYC 0.830377770217786 0.0477544831885907 -0.745260197790044 0.453852120838847 miRNAWalker2_validate;miRTarBase -0.427487830189717 0.00161403194033986 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 6.39965293994036 1.96920201593608e-18 -0.745260197790044 0.453852120838847 miRNAWalker2_validate -0.351232938868747 9.84375821791447e-07 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-let-7a-5p NKD1 0.148081801547773 0.645305441523746 -1.98089063442873 0.0698165327979292 TargetScan -0.5394886488876 0.0064772239484111 NA NA NA hsa-miR-200b-3p NKD1 5.56167217794639 6.43540045061709e-16 -1.98089063442873 0.0698165327979292 TargetScan -0.246261562772618 0.00407083131720379 NA NA NA hsa-miR-330-5p NKD1 2.25110496739954 0.000275527655397415 -1.98089063442873 0.0698165327979292 miRanda;miRNATAP -0.323051116539652 0.00114414069657017 NA NA NA hsa-miR-944 NKD1 7.20925181386398 0.000823207457340648 -1.98089063442873 0.0698165327979292 PITA;miRNATAP -0.104617511964737 0.00313578391544455 NA NA NA hsa-miR-125a-3p PARD3 -0.0748960586927341 0.920735897434087 0.542227201073621 0.230693760633387 MirTarget -0.170884089745551 3.60596934176484e-07 NA NA NA hsa-miR-181c-3p PARD3 0.451537053043082 0.423921169558333 0.542227201073621 0.230693760633387 MirTarget -0.231949446459885 2.29315424599605e-07 NA NA NA hsa-miR-589-3p PARD3 1.33205316880069 0.052632683806148 0.542227201073621 0.230693760633387 MirTarget -0.127223772580755 0.000649928774918833 NA NA NA hsa-let-7a-3p PARD6B 0.82512001802525 0.0468122405194487 1.50260239275565 0.00548989920152002 MirTarget;miRNATAP -0.243040367219493 0.0011598184566741 NA NA NA hsa-let-7b-3p PARD6B 0.589364128513318 0.200507534602851 1.50260239275565 0.00548989920152002 MirTarget;miRNATAP -0.196264345540477 0.00361636331214745 NA NA NA hsa-let-7c-5p PARD6B -2.03831836681378 0.0228401148731997 1.50260239275565 0.00548989920152002 MirTarget -0.116508668516135 0.000634959840112619 NA NA NA hsa-miR-205-5p PARD6B 8.08298115900323 3.83045179398654e-07 1.50260239275565 0.00548989920152002 miRNATAP -0.126228619871261 5.0887939874874e-12 NA NA NA hsa-miR-2355-3p PARD6B 0.494099635633886 0.483724014019781 1.50260239275565 0.00548989920152002 MirTarget;miRNATAP -0.121975739235221 0.00532282772575193 NA NA NA hsa-miR-27a-3p PARD6B 1.76094007417453 0.000216137556256765 1.50260239275565 0.00548989920152002 MirTarget;miRNATAP -0.25444881951842 7.30113493348828e-05 NA NA NA hsa-miR-27b-3p PARD6B -0.0929089601968123 0.85847352206581 1.50260239275565 0.00548989920152002 MirTarget;miRNATAP -0.285211086573784 1.20964657634076e-06 NA NA NA hsa-miR-409-3p PARD6B 0.293056353099264 0.67815482695354 1.50260239275565 0.00548989920152002 PITA -0.112963654440606 0.00986932569359738 NA NA NA hsa-miR-455-5p PARD6B -0.317715589860275 0.616296031007863 1.50260239275565 0.00548989920152002 miRanda -0.15133430987068 0.00185993903719447 NA NA NA hsa-miR-944 PARD6B 7.20925181386398 0.000823207457340648 1.50260239275565 0.00548989920152002 mirMAP;miRNATAP -0.111304257640544 7.62887368474218e-11 NA NA NA hsa-miR-106a-5p PARD6G 3.98693608217557 9.37722470816656e-07 0.0411770304766161 0.966724447266259 mirMAP -0.296892388622909 8.83112388496881e-06 NA NA NA hsa-miR-125a-3p PARD6G -0.0748960586927341 0.920735897434087 0.0411770304766161 0.966724447266259 miRanda -0.303345641174328 4.0637352215782e-05 NA NA NA hsa-miR-129-5p PARD6G -2.66843722411409 0.00695783358331245 0.0411770304766161 0.966724447266259 miRanda -0.163765039308351 0.00408594179316591 NA NA NA hsa-miR-20b-5p PARD6G 4.5662923200279 4.75238200639144e-05 0.0411770304766161 0.966724447266259 mirMAP -0.20473124142862 2.56459809095519e-05 NA NA NA hsa-miR-3065-5p PARD6G 2.14185373842821 0.0609400502269891 0.0411770304766161 0.966724447266259 MirTarget;mirMAP -0.209819689431584 0.000530092818812221 NA NA NA hsa-miR-582-3p PARD6G 0.280903327757368 0.772626550200977 0.0411770304766161 0.966724447266259 mirMAP -0.159985163485779 0.00533483271269844 NA NA NA hsa-miR-140-5p PPP1CB -0.634610285725923 0.126670572966239 -0.344515436156955 0.246326463628398 miRanda -0.110053965557512 0.00694267372795413 NA NA NA hsa-miR-148a-3p PPP1CB 1.1031350648218 0.052038169812979 -0.344515436156955 0.246326463628398 miRNATAP -0.109411117024396 0.000196115815353437 NA NA NA hsa-miR-181a-5p PPP1CB 1.25558293560636 0.00748975499703878 -0.344515436156955 0.246326463628398 mirMAP;miRNATAP -0.113565828154069 0.00146950689195981 NA NA NA hsa-miR-425-5p PPP2CB 3.15197291080781 3.16652350906107e-07 -1.25447828974493 1.05312923428955e-05 miRNAWalker2_validate -0.110681790089799 1.64448494638146e-05 NA NA NA hsa-miR-590-3p PPP2CB 2.35429565068338 2.79601879608564e-06 -1.25447828974493 1.05312923428955e-05 miRanda -0.128757858804767 5.16847568396067e-05 NA NA NA hsa-miR-125a-5p PPP2R1B -1.32352790615388 0.00714301627309467 0.535943295428266 0.162251997298493 PITA;miRanda -0.114930033410317 0.00930190483964423 NA NA NA hsa-miR-452-5p PPP2R1B 2.45466810475361 0.00114794259949532 0.535943295428266 0.162251997298493 MirTarget -0.106017919286185 0.000183245518742969 NA NA NA hsa-let-7d-5p PPP2R2A 0.831142050231414 0.0126955498524287 0.0960064985970766 0.7750778187388 miRNATAP -0.174926776698754 0.00247398044986799 NA NA NA hsa-let-7g-5p PPP2R2A 0.857251702023746 0.00647597344297273 0.0960064985970766 0.7750778187388 miRNATAP -0.176225566865877 0.00411980688463905 NA NA NA hsa-miR-10a-3p PPP2R2B 0.970411431936568 0.31667483998251 0.510382229560619 0.717532337027209 mirMAP -0.361340250716247 1.45994602012054e-05 NA NA NA hsa-miR-495-3p PPP2R2B -1.28495103468384 0.0979462503954353 0.510382229560619 0.717532337027209 mirMAP -0.288356788930344 0.00509581279052137 NA NA NA hsa-miR-10a-3p PPP2R2C 0.970411431936568 0.31667483998251 -2.54177583085932 0.149641186912383 mirMAP -0.52601694399535 4.06707476577951e-07 NA NA NA hsa-miR-125a-3p PPP2R2C -0.0748960586927341 0.920735897434087 -2.54177583085932 0.149641186912383 miRanda -0.356181842692916 0.00760457791329202 NA NA NA hsa-miR-192-5p PPP2R2C 1.77716187978541 0.113485496183047 -2.54177583085932 0.149641186912383 mirMAP -0.265151327819773 0.00280195654279779 NA NA NA hsa-miR-194-5p PPP2R2C 0.691219038144468 0.523143086635506 -2.54177583085932 0.149641186912383 miRNATAP -0.291408118524632 0.00155852789752536 NA NA NA hsa-miR-200b-3p PPP2R2C 5.56167217794639 6.43540045061709e-16 -2.54177583085932 0.149641186912383 TargetScan -0.540897516262644 8.39233236739658e-05 NA NA NA hsa-miR-200c-3p PPP2R2C 6.47012025883743 2.64500707716408e-26 -2.54177583085932 0.149641186912383 miRNATAP -0.449989786928302 0.00282829298525296 NA NA NA hsa-miR-429 PPP2R2C 6.39965293994036 1.96920201593608e-18 -2.54177583085932 0.149641186912383 PITA;miRanda;miRNATAP -0.403238519278253 0.00175993756486531 NA NA NA hsa-miR-625-5p PPP2R2C 2.02792641909347 0.000935142379948297 -2.54177583085932 0.149641186912383 MirTarget -0.593528145578647 0.000275541485817671 NA NA NA hsa-miR-126-5p PRKCI -0.420466581381807 0.329972801718418 1.20093288739627 0.00283173254855104 mirMAP -0.158380236262743 0.00310981886432263 NA NA NA hsa-miR-140-3p PRKCI -1.9828800596692 8.92876132959514e-08 1.20093288739627 0.00283173254855104 PITA -0.248375818242268 4.56804060004973e-05 NA NA NA hsa-miR-29a-5p PRKCI 0.0748295222568571 0.884125894063293 1.20093288739627 0.00283173254855104 mirMAP -0.139595672183284 0.00183287148855928 NA NA NA hsa-miR-590-3p PRKCI 2.35429565068338 2.79601879608564e-06 1.20093288739627 0.00283173254855104 MirTarget;miRanda;mirMAP -0.120013420382855 0.0077678253929957 NA NA NA hsa-miR-130b-3p RASSF1 3.9204771543282 1.2714917955808e-11 -0.675992298792059 0.0535906542791148 miRNAWalker2_validate -0.107860774954182 0.00109638821196713 NA NA NA hsa-miR-542-3p RASSF1 -0.376147863244659 0.438002751207043 -0.675992298792059 0.0535906542791148 miRanda -0.150721762850586 0.000234809305638747 NA NA NA hsa-miR-744-5p RASSF1 1.03691757606528 0.0434004722240021 -0.675992298792059 0.0535906542791148 miRNAWalker2_validate -0.141966863449307 0.000230200716769652 NA NA NA hsa-miR-130a-3p RASSF6 0.176861046122832 0.7577473016872 4.23095760045198 0.000141851289794478 mirMAP -0.35537658994231 0.00143290706738024 NA NA NA hsa-miR-203a-3p RASSF6 6.35084246337388 7.89944323347948e-08 4.23095760045198 0.000141851289794478 MirTarget -0.192884262528438 0.000224681875402375 NA NA NA hsa-miR-301a-3p RASSF6 1.99338115332667 0.000813358604963724 4.23095760045198 0.000141851289794478 mirMAP -0.280406720158851 0.00852989657996145 NA NA NA hsa-miR-590-5p RASSF6 1.51400888103768 0.0023888567923017 4.23095760045198 0.000141851289794478 miRanda;miRNATAP -0.343346864259037 0.00730121080994467 NA NA NA hsa-miR-944 RASSF6 7.20925181386398 0.000823207457340648 4.23095760045198 0.000141851289794478 MirTarget;mirMAP -0.12322237505535 0.000684866569892376 NA NA NA hsa-miR-186-5p SAV1 0.445443449112564 0.185447310527704 -0.672711129555663 0.0366925718165166 mirMAP -0.182367296223709 0.000949434447328917 NA NA NA hsa-miR-590-3p SAV1 2.35429565068338 2.79601879608564e-06 -0.672711129555663 0.0366925718165166 miRanda;mirMAP;miRNATAP -0.128628011119102 0.000314227074943868 NA NA NA hsa-miR-664a-3p SAV1 0.249882351950296 0.56171157318348 -0.672711129555663 0.0366925718165166 mirMAP -0.126068779568357 0.0031842360113677 NA NA NA hsa-miR-30c-5p SERPINE1 0.38723991118075 0.348605235643473 0.617692230647947 0.572474588134307 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.430478549390397 0.00464929561193146 NA NA NA hsa-miR-30d-5p SERPINE1 0.302504510257496 0.380193536606962 0.617692230647947 0.572474588134307 miRNATAP -0.571023174230567 0.00187005473771538 NA NA NA hsa-miR-34a-5p SERPINE1 0.830377770217786 0.0477544831885907 0.617692230647947 0.572474588134307 miRNATAP -0.454822685947182 0.00229694402077437 NA NA NA hsa-miR-378a-5p SERPINE1 1.25775140086104 0.0500877723587615 0.617692230647947 0.572474588134307 MirTarget -0.403730798540002 2.50727400864339e-05 NA NA NA hsa-miR-99a-5p SERPINE1 -2.72139054000803 0.00621971944534118 0.617692230647947 0.572474588134307 miRNAWalker2_validate -0.208155381578803 0.000740541769690584 NA NA NA hsa-miR-30a-5p SMAD1 -0.768430903969183 0.320487552854215 -0.661773172110887 0.109183209000537 miRNAWalker2_validate;miRTarBase -0.136305243025811 5.1078361443971e-06 NA NA NA hsa-let-7g-3p SMAD3 2.09736290930341 5.30067796437833e-05 0.160014583572917 0.778517282766047 mirMAP -0.257984897034794 2.44423650375142e-05 NA NA NA hsa-miR-17-5p SMAD3 2.3269271449522 2.13987445663942e-05 0.160014583572917 0.778517282766047 miRNAWalker2_validate -0.165009353618131 0.00461261808419179 NA NA NA hsa-miR-186-5p SMAD3 0.445443449112564 0.185447310527704 0.160014583572917 0.778517282766047 mirMAP -0.742764319550064 2.12349457043014e-15 NA NA NA hsa-miR-188-5p SMAD3 1.39111178824125 0.0251592818948912 0.160014583572917 0.778517282766047 PITA -0.238758119317103 3.46346507109757e-06 NA NA NA hsa-miR-28-5p SMAD3 -0.815636722979196 0.0221199948901761 0.160014583572917 0.778517282766047 miRNATAP -0.238288702750939 0.00948140473131226 NA NA NA hsa-miR-29b-2-5p SMAD3 -0.596051745078872 0.189540844841389 0.160014583572917 0.778517282766047 mirMAP -0.33018047859631 3.00181288669247e-06 NA NA NA hsa-miR-30a-3p SMAD3 -1.22212086897848 0.167565797592104 0.160014583572917 0.778517282766047 mirMAP -0.125743455849957 0.000500972339732145 NA NA NA hsa-miR-30d-3p SMAD3 -0.0740421896025512 0.857423650167556 0.160014583572917 0.778517282766047 mirMAP -0.265215856067837 0.000784444342632096 NA NA NA hsa-miR-32-3p SMAD3 2.20477794939766 0.0392771274032852 0.160014583572917 0.778517282766047 mirMAP -0.139443193805526 0.00854369021916498 NA NA NA hsa-miR-335-3p SMAD3 1.19503568251824 0.0938852560631551 0.160014583572917 0.778517282766047 mirMAP -0.150203529209219 0.000833797912476475 NA NA NA hsa-miR-335-5p SMAD3 0.167216045757305 0.803897055331049 0.160014583572917 0.778517282766047 miRNAWalker2_validate -0.170051000133026 0.000363968836124472 NA NA NA hsa-miR-345-5p SMAD3 2.77314563304336 4.34343702412489e-05 0.160014583572917 0.778517282766047 mirMAP -0.193422457386819 3.24971867546412e-05 NA NA NA hsa-miR-501-5p SMAD3 1.0411896821345 0.0777206709183552 0.160014583572917 0.778517282766047 mirMAP -0.280514332977103 1.82290826802372e-07 NA NA NA hsa-miR-589-3p SMAD3 1.33205316880069 0.052632683806148 0.160014583572917 0.778517282766047 mirMAP -0.202014876353946 1.49389042617214e-05 NA NA NA hsa-miR-616-5p SMAD3 2.48416313933027 0.00318247475868827 0.160014583572917 0.778517282766047 mirMAP -0.241397292057418 2.69938790277874e-07 NA NA NA hsa-miR-671-5p SMAD3 1.48527046124636 0.00686722328347111 0.160014583572917 0.778517282766047 MirTarget -0.193412590030654 0.000928749665735432 NA NA NA hsa-miR-7-1-3p SMAD3 1.43074343339835 0.00471215970502094 0.160014583572917 0.778517282766047 mirMAP -0.168365832898427 0.00819700709319524 NA NA NA hsa-miR-769-5p SMAD3 0.41777775802937 0.343089124193569 0.160014583572917 0.778517282766047 miRNATAP -0.366412732630904 4.82674495052425e-07 NA NA NA hsa-miR-21-3p SMAD4 3.50297439576639 6.39946844099206e-10 -1.1222647897474 0.00638923144286853 mirMAP -0.112729088104479 0.00502861854832022 NA NA NA hsa-miR-27a-3p SMAD4 1.76094007417453 0.000216137556256765 -1.1222647897474 0.00638923144286853 MirTarget -0.132335336531126 0.00695151522053189 NA NA NA hsa-miR-106a-5p SMAD7 3.98693608217557 9.37722470816656e-07 -0.95880969992043 0.0366992059513236 miRNATAP -0.149963254737491 1.31781139734866e-06 NA NA NA hsa-miR-106b-5p SMAD7 2.80565545918114 1.14547999022566e-09 -0.95880969992043 0.0366992059513236 miRNATAP -0.153866006306842 0.00543882440686572 27619676;25286029;22286770 MiR 106b promotes migration and invasion through enhancing EMT via downregulation of Smad 7 in Kazakh's esophageal squamous cell carcinoma; To understand the regulation between miR-106b and Smad 7 qRT-PCR and western blot were performed; Smad 7 was confirmed as a downstream target of miR-106b in our experimental setting; Our results indicated that miR-106b can promote migration and invasion of ESCC cells through enhancing EMT process via downregulation of Smad 7 suggesting that miR-106b can be a potential molecular phenotype in ESCC metastases;Smad7 which inhibits transforming growth factor-β TGF-β/Smad signaling as a target of the miR-106b family was downregulated in CD44+ cells;The miR 106b 25 cluster targets Smad7 activates TGF β signaling and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer metastasis;; esophageal cancer;gastric cancer;breast cancer hsa-miR-200b-3p SMAD7 5.56167217794639 6.43540045061709e-16 -0.95880969992043 0.0366992059513236 TargetScan;mirMAP -0.134092196812711 0.00017837402933657 NA NA NA hsa-miR-25-3p SMAD7 1.12623030168869 0.00311079344417173 -0.95880969992043 0.0366992059513236 miRNAWalker2_validate;MirTarget;miRNATAP -0.211174530736138 0.00218469576403061 23435373 MicroRNA 25 functions as a potential tumor suppressor in colon cancer by targeting Smad7; Furthermore bioinformatic predictions and experimental validation were used to identify Smad7 as a direct target of miR-25; Functional reverse experiments indicated that the antitumor effects of miR-25 were probably mediated by its repression of Smad7; These results suggest that miR-25 may function as a tumor suppressor by targeting Smad7 in colon cancer colon cancer hsa-miR-32-5p SMAD7 2.93035124381469 5.00149131394151e-10 -0.95880969992043 0.0366992059513236 MirTarget;miRNATAP -0.150227679757323 0.00543246914204553 NA NA NA hsa-miR-34a-5p SMAD7 0.830377770217786 0.0477544831885907 -0.95880969992043 0.0366992059513236 MirTarget -0.162394705492837 0.00963037319305692 NA NA NA hsa-miR-363-3p SMAD7 4.27232887548977 8.53979362839458e-06 -0.95880969992043 0.0366992059513236 MirTarget;miRNATAP -0.129488951229613 8.8174349390813e-07 NA NA NA hsa-miR-590-3p SMAD7 2.35429565068338 2.79601879608564e-06 -0.95880969992043 0.0366992059513236 miRanda -0.142111999176971 0.00557772133316168 NA NA NA hsa-miR-96-5p SMAD7 5.62521466029286 1.54938806718028e-10 -0.95880969992043 0.0366992059513236 TargetScan;miRNATAP -0.109077445631336 0.00187568919830877 NA NA NA hsa-miR-107 SNAI2 1.49443409571439 0.000130594521065411 -1.63105031719645 0.151947151729511 miRanda -0.697492767535727 2.28747541234486e-05 NA NA NA hsa-miR-148b-3p SNAI2 1.75622244535669 8.84414356040579e-08 -1.63105031719645 0.151947151729511 miRNAWalker2_validate -1.20416541853834 3.64181808017381e-10 NA NA NA hsa-miR-182-5p SNAI2 5.86988712704738 1.22411588571584e-15 -1.63105031719645 0.151947151729511 miRNAWalker2_validate;miRNATAP -0.350535353498724 2.46839505266114e-05 NA NA NA hsa-miR-200b-3p SNAI2 5.56167217794639 6.43540045061709e-16 -1.63105031719645 0.151947151729511 TargetScan -0.649397403907546 3.78497809111695e-14 NA NA NA hsa-miR-200c-3p SNAI2 6.47012025883743 2.64500707716408e-26 -1.63105031719645 0.151947151729511 miRNATAP -0.366231228387546 0.000154734539121361 NA NA NA hsa-miR-375 SNAI2 3.3784490463318 0.0449946294355695 -1.63105031719645 0.151947151729511 miRanda -0.405761563211418 3.15055753376226e-32 NA NA NA hsa-miR-429 SNAI2 6.39965293994036 1.96920201593608e-18 -1.63105031719645 0.151947151729511 PITA;miRanda;miRNATAP -0.555621837620757 5.73431212612017e-12 NA NA NA hsa-miR-532-5p SNAI2 -0.297424983759107 0.503934707453099 -1.63105031719645 0.151947151729511 PITA -0.961387727223608 1.45748468588014e-11 NA NA NA hsa-miR-96-5p SNAI2 5.62521466029286 1.54938806718028e-10 -1.63105031719645 0.151947151729511 miRNATAP -0.459083416473505 8.67842804706358e-08 NA NA NA hsa-let-7g-3p SOX2 2.09736290930341 5.30067796437833e-05 5.62999413472184 0.00776803411146197 miRNATAP -0.749326670756416 0.00114213274933256 NA NA NA hsa-miR-590-5p SOX2 1.51400888103768 0.0023888567923017 5.62999413472184 0.00776803411146197 PITA;miRanda;miRNATAP -0.725609246899362 0.00268261902221072 NA NA NA hsa-miR-140-5p STK3 -0.634610285725923 0.126670572966239 -0.130071437281501 0.665272694668143 PITA;miRanda -0.163815378245803 6.24798783355841e-05 NA NA NA hsa-miR-28-3p STK3 -0.992446114847535 0.0188188359018203 -0.130071437281501 0.665272694668143 MirTarget;PITA -0.122015424625475 0.0024872998460855 NA NA NA hsa-miR-29b-2-5p STK3 -0.596051745078872 0.189540844841389 -0.130071437281501 0.665272694668143 MirTarget -0.11593186403124 0.00200385372125216 NA NA NA hsa-miR-142-5p TCF7L1 3.95552531913424 1.49536283724079e-08 -2.01358509693913 0.0134449848880761 PITA -0.212267103740507 0.00102071148741226 NA NA NA hsa-miR-200a-3p TCF7L1 6.336081120041 4.024313571871e-16 -2.01358509693913 0.0134449848880761 miRNAWalker2_validate -0.203461925521664 0.000299485175056615 NA NA NA hsa-miR-200b-3p TCF7L1 5.56167217794639 6.43540045061709e-16 -2.01358509693913 0.0134449848880761 miRNAWalker2_validate -0.213878073046112 0.000814272240549089 NA NA NA hsa-miR-155-5p TCF7L2 2.81443182173772 7.42530504828797e-05 -1.23546095022525 0.000440438934902147 MirTarget;miRNATAP -0.104046086417659 0.000174591712156132 NA NA NA hsa-miR-193a-3p TCF7L2 0.646392169474854 0.207134343676122 -1.23546095022525 0.000440438934902147 miRanda -0.157722671038068 5.3142399209646e-05 NA NA NA hsa-miR-942-5p TCF7L2 3.36242661558642 1.89848306955335e-10 -1.23546095022525 0.000440438934902147 MirTarget -0.146878706302034 6.24208059630175e-05 NA NA NA hsa-miR-142-3p TEAD1 4.35304505457969 3.10014573651358e-10 -1.05192778611214 0.0205184032916969 MirTarget;PITA;miRNATAP -0.144298128983618 5.85055114160252e-05 NA NA NA hsa-miR-29c-3p TEAD1 -0.414153610337085 0.529344128062017 -1.05192778611214 0.0205184032916969 mirMAP -0.115839049311896 0.00311459932819054 NA NA NA hsa-miR-3607-3p TEAD1 1.38015131722213 0.0240067155694847 -1.05192778611214 0.0205184032916969 miRNATAP -0.117827918915283 0.00514322946990757 NA NA NA hsa-miR-590-3p TEAD1 2.35429565068338 2.79601879608564e-06 -1.05192778611214 0.0205184032916969 MirTarget;PITA;miRanda;miRNATAP -0.195745949781913 0.000104844823344981 NA NA NA hsa-let-7g-5p TEAD3 0.857251702023746 0.00647597344297273 -0.930461554620337 0.00615365289589674 miRNATAP -0.200437282765867 0.00131192704455034 NA NA NA hsa-miR-339-5p TEAD3 1.23326828594484 0.0307501214818698 -0.930461554620337 0.00615365289589674 miRanda -0.171894116718717 2.35435040851779e-07 NA NA NA hsa-miR-374b-5p TEAD3 -0.114749866169918 0.764888930049438 -0.930461554620337 0.00615365289589674 miRNATAP -0.147249204190451 0.00390384106906942 NA NA NA hsa-miR-532-3p TEAD3 0.643755490841218 0.214842585969913 -0.930461554620337 0.00615365289589674 miRNATAP -0.104197006462144 0.00523241822165748 NA NA NA hsa-miR-590-3p TEAD3 2.35429565068338 2.79601879608564e-06 -0.930461554620337 0.00615365289589674 miRNATAP -0.117316955553223 0.00195473903550506 NA NA NA hsa-miR-141-3p TGFB2 7.30474126597325 1.45115996357606e-24 -1.43663821995393 0.208151431685717 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.215624739416799 0.00999464963415708 NA NA NA hsa-miR-142-3p TGFB2 4.35304505457969 3.10014573651358e-10 -1.43663821995393 0.208151431685717 miRNATAP -0.239982637825598 0.00829657759355293 NA NA NA hsa-miR-148b-3p TGFB2 1.75622244535669 8.84414356040579e-08 -1.43663821995393 0.208151431685717 MirTarget -0.652112155639784 0.000929853930431754 NA NA NA hsa-miR-200a-3p TGFB2 6.336081120041 4.024313571871e-16 -1.43663821995393 0.208151431685717 MirTarget;miRNATAP -0.351128170275698 7.00885632360109e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 6.35084246337388 7.89944323347948e-08 -1.43663821995393 0.208151431685717 MirTarget -0.267521839692763 3.62940840958117e-07 NA NA NA hsa-miR-2277-5p TGFB2 3.02139935290539 0.0134629626930938 -1.43663821995393 0.208151431685717 MirTarget -0.249573719882911 0.00777879243940924 NA NA NA hsa-miR-362-5p TGFB2 -1.22309034685697 0.0452665543907975 -1.43663821995393 0.208151431685717 MirTarget -0.314690950040788 0.00297612558507577 NA NA NA hsa-miR-375 TGFB2 3.3784490463318 0.0449946294355695 -1.43663821995393 0.208151431685717 miRNAWalker2_validate -0.113027113272895 0.00302877404950613 NA NA NA hsa-miR-429 TGFB2 6.39965293994036 1.96920201593608e-18 -1.43663821995393 0.208151431685717 miRNATAP -0.317868138018968 0.000128726503171991 NA NA NA hsa-miR-500a-5p TGFB2 0.0170829425378565 0.973960207660626 -1.43663821995393 0.208151431685717 mirMAP -0.329451267369997 0.00832586461531593 NA NA NA hsa-miR-500b-5p TGFB2 0.0167434146432646 0.974498641907253 -1.43663821995393 0.208151431685717 MirTarget -0.327405186316064 0.00868447231417683 NA NA NA hsa-let-7f-1-3p TGFB3 1.61507869803314 0.00069342464777815 -2.17732916051247 0.00128816902304754 MirTarget -0.28544584743246 0.000437940636180159 NA NA NA hsa-miR-151a-5p TGFB3 1.0755926560327 0.00684662665520532 -2.17732916051247 0.00128816902304754 MirTarget -0.500615620870658 2.12682352848945e-07 NA NA NA hsa-miR-629-3p TGFB3 3.48282157979573 4.9176538695908e-08 -2.17732916051247 0.00128816902304754 MirTarget -0.241806561248301 3.8838732840276e-05 NA NA NA hsa-let-7b-5p TGFBR1 -0.189422992330471 0.651878220048983 -0.505713612135208 0.324744061078335 miRNATAP -0.242601587479934 0.000517890990887836 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC; In luciferase assays the risk-associated allele for rs868 was associated with half the luciferase expression in the presence of miRNA let-7b-5p compared with protective allele suggesting more binding of let-7b-5p and less TGFBR1 expression colorectal cancer hsa-let-7c-5p TGFBR1 -2.03831836681378 0.0228401148731997 -0.505713612135208 0.324744061078335 miRNAWalker2_validate;miRTarBase -0.141642653096274 9.4282969596595e-06 NA NA NA hsa-let-7g-5p TGFBR1 0.857251702023746 0.00647597344297273 -0.505713612135208 0.324744061078335 miRNATAP -0.267873123242374 0.00450205280436413 NA NA NA hsa-miR-101-3p TGFBR1 -1.12421603598195 0.0200907284788457 -0.505713612135208 0.324744061078335 miRNAWalker2_validate;miRNATAP -0.25766117737473 1.65614003073399e-05 NA NA NA hsa-miR-101-5p TGFBR1 -1.41522721523565 0.0166784131265028 -0.505713612135208 0.324744061078335 mirMAP -0.147066901987004 0.00277627040116552 NA NA NA hsa-miR-128-3p TGFBR1 1.36248409467631 0.00408435995818078 -0.505713612135208 0.324744061078335 miRNAWalker2_validate;miRTarBase -0.218506283449698 0.000352839376558225 NA NA NA hsa-miR-200b-3p TGFBR1 5.56167217794639 6.43540045061709e-16 -0.505713612135208 0.324744061078335 mirMAP -0.254716587127543 6.86106889972148e-11 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-3065-5p TGFBR1 2.14185373842821 0.0609400502269891 -0.505713612135208 0.324744061078335 mirMAP -0.111612566907259 0.000387470900601915 NA NA NA hsa-miR-361-5p TGFBR1 0.00649167180664723 0.985202350239079 -0.505713612135208 0.324744061078335 miRanda;mirMAP;miRNATAP -0.236124496506177 0.00538272648027843 NA NA NA hsa-miR-374a-5p TGFBR1 0.278549982012055 0.45888283715888 -0.505713612135208 0.324744061078335 mirMAP -0.235099661936825 0.0027662227971746 NA NA NA hsa-miR-429 TGFBR1 6.39965293994036 1.96920201593608e-18 -0.505713612135208 0.324744061078335 miRanda;miRNATAP -0.219958031472476 1.89353165194703e-09 NA NA NA hsa-miR-452-5p TGFBR1 2.45466810475361 0.00114794259949532 -0.505713612135208 0.324744061078335 mirMAP -0.12029641667783 0.00160222545222133 NA NA NA hsa-miR-106a-5p TGFBR2 3.98693608217557 9.37722470816656e-07 -2.73335386207413 1.90521047769449e-05 miRTarBase;miRNATAP -0.150075579446973 0.000678032994747311 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 2.80565545918114 1.14547999022566e-09 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.322471465860215 3.16067025691578e-05 NA NA NA hsa-miR-130b-3p TGFBR2 3.9204771543282 1.2714917955808e-11 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRNATAP -0.213593769351299 0.000481445052465677 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 2.3269271449522 2.13987445663942e-05 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.215187086531778 0.00117456700436254 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-19b-3p TGFBR2 1.67581705793313 0.000858910586302716 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRNATAP -0.234916804375819 0.0012466880966742 NA NA NA hsa-miR-20a-5p TGFBR2 2.13553469875764 0.000181201072324354 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.20359230487236 0.00142468050698815 NA NA NA hsa-miR-23a-3p TGFBR2 0.925125296618358 0.0127293543936914 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.3112107869471 0.00186820770972094 NA NA NA hsa-miR-23b-3p TGFBR2 -0.581135273821923 0.190478897170459 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.396202249615838 1.57688737786639e-06 NA NA NA hsa-miR-33a-3p TGFBR2 2.06269680799532 0.00156436055383943 -2.73335386207413 1.90521047769449e-05 mirMAP -0.339046189283903 6.57537246748805e-10 NA NA NA hsa-miR-429 TGFBR2 6.39965293994036 1.96920201593608e-18 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.154633278802292 0.00105886610005129 NA NA NA hsa-miR-502-5p TGFBR2 -0.614788359240004 0.318237800399635 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.208965899672639 0.000640450504063216 NA NA NA hsa-miR-590-3p TGFBR2 2.35429565068338 2.79601879608564e-06 -2.73335386207413 1.90521047769449e-05 miRanda -0.257641439028576 0.000348477751441795 NA NA NA hsa-miR-590-5p TGFBR2 1.51400888103768 0.0023888567923017 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.215019200724794 0.00350246324243056 NA NA NA hsa-miR-9-3p TGFBR2 1.69328215716742 0.125170982657059 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.160602299630754 1.35393247444156e-06 NA NA NA hsa-miR-9-5p TGFBR2 1.79620806707734 0.14526963042518 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.159363587250353 4.39117866793099e-08 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 1.87892405805529 1.27013821556583e-05 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate -0.35871093164404 2.09836401920038e-05 NA NA NA hsa-miR-93-5p TGFBR2 2.65964181833033 2.58315947526774e-08 -2.73335386207413 1.90521047769449e-05 miRNAWalker2_validate;miRNATAP -0.331832507260209 9.43453774065979e-06 NA NA NA hsa-miR-192-5p TP73 1.77716187978541 0.113485496183047 6.73461147555657 6.31501771558468e-15 mirMAP -0.125949998024971 0.00567396966274381 NA NA NA hsa-miR-335-5p TP73 0.167216045757305 0.803897055331049 6.73461147555657 6.31501771558468e-15 mirMAP -0.293450631584882 0.000112060876458774 NA NA NA hsa-miR-664a-3p WNT10A 0.249882351950296 0.56171157318348 4.50187444135611 0.000590394273747734 mirMAP -0.487836890480239 0.00563420427073706 NA NA NA hsa-miR-590-3p WNT11 2.35429565068338 2.79601879608564e-06 -1.12002304030541 0.399603501707316 miRanda -0.529097966959972 0.000347687911762461 NA NA NA hsa-miR-146b-3p WNT16 1.34608871980101 0.00935728391852709 0.34788001398837 0.748349917696045 MirTarget -0.37742443073334 0.00145623124068643 NA NA NA hsa-miR-338-3p WNT16 0.447551118940466 0.558485097370031 0.34788001398837 0.748349917696045 miRanda -0.226165128589222 0.00487183921721476 NA NA NA hsa-miR-339-5p WNT16 1.23326828594484 0.0307501214818698 0.34788001398837 0.748349917696045 miRanda -0.331104236072021 0.00208818597534857 NA NA NA hsa-let-7f-2-3p WNT2 1.02768112108475 0.0787293499732611 -3.299390730363 0.00348976107203057 MirTarget -0.299782609265936 0.00806308209760041 NA NA NA hsa-miR-324-5p WNT2 1.31253452379847 0.0116806680545163 -3.299390730363 0.00348976107203057 miRanda -0.36189140777637 0.00350229441341699 NA NA NA hsa-miR-335-3p WNT2 1.19503568251824 0.0938852560631551 -3.299390730363 0.00348976107203057 mirMAP -0.35269768882803 8.41491455046423e-05 NA NA NA hsa-miR-944 WNT2 7.20925181386398 0.000823207457340648 -3.299390730363 0.00348976107203057 mirMAP -0.146635065441429 6.02984984638211e-05 NA NA NA hsa-miR-125a-3p WNT2B -0.0748960586927341 0.920735897434087 -0.856171452484765 0.502995562863325 miRanda -0.504617595226248 1.05618585936844e-07 NA NA NA hsa-miR-186-5p WNT2B 0.445443449112564 0.185447310527704 -0.856171452484765 0.502995562863325 mirMAP -0.83839518234891 0.000129537010945903 NA NA NA hsa-miR-301a-3p WNT2B 1.99338115332667 0.000813358604963724 -0.856171452484765 0.502995562863325 MirTarget -0.342895282405635 0.00462467447879055 NA NA NA hsa-miR-616-5p WNT2B 2.48416313933027 0.00318247475868827 -0.856171452484765 0.502995562863325 mirMAP -0.509721719846027 1.50040236285173e-06 NA NA NA hsa-miR-192-5p WNT3 1.77716187978541 0.113485496183047 3.00467776067193 0.00323304601055451 miRNAWalker2_validate -0.152954353312327 0.00301888019712671 NA NA NA hsa-miR-107 WNT4 1.49443409571439 0.000130594521065411 0.346156151965651 0.759005168873886 PITA;miRNATAP -0.706595074754511 1.43378256348642e-05 NA NA NA hsa-miR-141-3p WNT5A 7.30474126597325 1.45115996357606e-24 -0.335254267155151 0.714960765245992 TargetScan -0.185678372077036 0.00570301174175726 NA NA NA hsa-miR-15b-3p WNT5A 3.57530146629867 5.89922785773482e-11 -0.335254267155151 0.714960765245992 mirMAP -0.24311589972858 0.00863820879774156 NA NA NA hsa-miR-16-2-3p WNT5A 3.79845098071094 1.49120139344659e-13 -0.335254267155151 0.714960765245992 MirTarget;mirMAP -0.311764225567874 0.00135279684345927 NA NA NA hsa-miR-16-5p WNT5A 2.93575808220754 2.15436817162977e-10 -0.335254267155151 0.714960765245992 miRNAWalker2_validate -0.290441753916783 0.00829455186858816 NA NA NA hsa-miR-2110 WNT5A 1.8070969695103 0.00137196847440523 -0.335254267155151 0.714960765245992 MirTarget -0.30255767867938 0.00122728628679992 NA NA NA hsa-miR-30c-5p WNT5A 0.38723991118075 0.348605235643473 -0.335254267155151 0.714960765245992 mirMAP -0.369350346658232 0.00376556464462393 NA NA NA hsa-miR-30d-3p WNT5A -0.0740421896025512 0.857423650167556 -0.335254267155151 0.714960765245992 mirMAP -0.440328526023165 0.000555223243909098 NA NA NA hsa-miR-30d-5p WNT5A 0.302504510257496 0.380193536606962 -0.335254267155151 0.714960765245992 mirMAP -0.416582436731857 0.00691722632235903 NA NA NA hsa-miR-30e-5p WNT5A 0.780047227271616 0.0346714425913016 -0.335254267155151 0.714960765245992 mirMAP -0.392965061384389 0.00598951520393619 NA NA NA hsa-miR-330-5p WNT5A 2.25110496739954 0.000275527655397415 -0.335254267155151 0.714960765245992 miRanda -0.317182601686914 0.00013146381356929 NA NA NA hsa-miR-582-5p WNT5A 0.685177900016753 0.447761540297692 -0.335254267155151 0.714960765245992 miRNATAP -0.175734719122522 0.00222477334080145 NA NA NA hsa-miR-616-5p WNT5A 2.48416313933027 0.00318247475868827 -0.335254267155151 0.714960765245992 mirMAP -0.276707442691596 0.000306684343847227 NA NA NA hsa-miR-92a-3p WNT5A 1.87892405805529 1.27013821556583e-05 -0.335254267155151 0.714960765245992 miRNAWalker2_validate -0.492024474546178 3.85220646721685e-05 NA NA NA hsa-miR-103a-3p WNT7A 0.990919087251708 0.00468308601422847 1.99490211423871 0.283859716193086 MirTarget -1.32781551331516 1.1801181900249e-05 NA NA NA hsa-miR-107 WNT7A 1.49443409571439 0.000130594521065411 1.99490211423871 0.283859716193086 MirTarget;miRanda -0.773176469447409 0.00437990373456198 NA NA NA hsa-miR-15b-5p WNT7A 3.32329949959268 8.40210501034588e-13 1.99490211423871 0.283859716193086 MirTarget -0.65869802593554 0.00275936276249016 27195958 WNT7A Regulation by miR 15b in Ovarian Cancer; In the present study we report that WNT7A is a direct target of miR-15b in ovarian cancer; We showed that a luciferase reporter containing the putative binding site of miR-15b in the WNT7A 3'-UTR was significantly repressed by miR-15b; Mutation of the putative binding site of miR-15b in the WNT7A 3'-UTR restored luciferase activity; Furthermore miR-15b was able to repress increased levels of TOPFLASH activity by WNT7A but not those induced by S33Y; Additionally miR-15b dose-dependently decreased WNT7A expression; When we evaluated the prognostic impact of WNT7A and miR-15b expression using TCGA datasets a significant inverse correlation in which high-expression of WNT7A and low-expression of miR-15b was associated with reduced survival rates of ovarian cancer patients; These results suggest that WNT7A is post-transcriptionally regulated by miR-15b which could be down-regulated by promoter hypermethylation potentially via DNMT1 in ovarian cancer poor survival ovarian cancer hsa-miR-361-5p WNT7A 0.00649167180664723 0.985202350239079 1.99490211423871 0.283859716193086 MirTarget;PITA;miRanda -1.43618972738794 2.43966057288788e-06 NA NA NA hsa-miR-592 WNT7A 2.80403350008555 0.0293520213681333 1.99490211423871 0.283859716193086 mirMAP -0.379438925337118 0.000144596464812367 NA NA NA hsa-miR-10a-5p WNT7B -0.482300926520507 0.594608783320466 6.45833028681074 1.2743062072308e-11 mirMAP -0.22213369773385 0.000303981788598836 NA NA NA hsa-miR-10b-5p WNT7B -3.08172917642729 4.22675074435126e-09 6.45833028681074 1.2743062072308e-11 mirMAP -0.465142626600515 7.06702462289464e-06 NA NA NA hsa-miR-491-5p WNT7B 0.569358547192776 0.313310594748302 6.45833028681074 1.2743062072308e-11 mirMAP -0.330184477241142 0.00107310673487806 NA NA NA hsa-miR-505-3p WNT7B 0.58881333170866 0.226937454637888 6.45833028681074 1.2743062072308e-11 miRNATAP -0.344371689601171 0.00293288321292057 NA NA NA hsa-miR-148a-3p WNT9A 1.1031350648218 0.052038169812979 -1.18407404695739 0.266101963440536 mirMAP -0.432898371967406 4.26603455945752e-05 NA NA NA hsa-miR-148b-3p WNT9A 1.75622244535669 8.84414356040579e-08 -1.18407404695739 0.266101963440536 mirMAP -0.87883765663712 1.34304427585441e-06 NA NA NA hsa-miR-32-5p WNT9A 2.93035124381469 5.00149131394151e-10 -1.18407404695739 0.266101963440536 mirMAP -0.363977517670086 0.00367377284132333 NA NA NA hsa-miR-331-3p WNT9A 2.60769294751513 3.84318952029483e-07 -1.18407404695739 0.266101963440536 mirMAP -0.356933157833057 0.00205063036870332 NA NA NA hsa-miR-335-5p WNT9A 0.167216045757305 0.803897055331049 -1.18407404695739 0.266101963440536 miRNAWalker2_validate -0.317725285709137 0.000385124583476028 NA NA NA hsa-miR-589-3p WNT9A 1.33205316880069 0.052632683806148 -1.18407404695739 0.266101963440536 mirMAP -0.360413992507261 3.93582105522619e-05 NA NA NA hsa-miR-96-5p WNT9A 5.62521466029286 1.54938806718028e-10 -1.18407404695739 0.266101963440536 mirMAP -0.234533115491296 0.00400004958215225 NA NA NA hsa-miR-200a-3p WTIP 6.336081120041 4.024313571871e-16 -2.28702770726066 0.00408409230581306 mirMAP -0.156082728816863 0.00479238591310846 NA NA NA hsa-miR-224-3p WTIP 2.84876340814503 0.000179138399939161 -2.28702770726066 0.00408409230581306 mirMAP -0.167587006274971 0.00488736832832385 NA NA NA hsa-miR-27b-3p WTIP -0.0929089601968123 0.85847352206581 -2.28702770726066 0.00408409230581306 mirMAP -0.279961148993713 0.00138763460539199 NA NA NA hsa-miR-363-3p WTIP 4.27232887548977 8.53979362839458e-06 -2.28702770726066 0.00408409230581306 mirMAP -0.120219088689662 0.00989316408930969 NA NA NA hsa-miR-1-3p WWC1 -3.85397883903804 6.93274972711165e-06 6.1944615747144 1.20736094219385e-16 MirTarget -0.273270178071966 6.25561795723836e-08 NA NA NA hsa-miR-195-5p WWC1 -1.59182537400701 0.0169128463756769 6.1944615747144 1.20736094219385e-16 MirTarget;miRNATAP -0.310526639032598 2.71037417464743e-06 NA NA NA hsa-miR-28-5p WWC1 -0.815636722979196 0.0221199948901761 6.1944615747144 1.20736094219385e-16 mirMAP -0.432996458831729 0.0006600043704188 NA NA NA hsa-miR-376c-3p WWC1 -1.21717646554485 0.13104967196319 6.1944615747144 1.20736094219385e-16 mirMAP -0.145291177312451 0.00956441128298126 NA NA NA hsa-miR-497-5p WWC1 -1.44150596209372 0.0225146607606395 6.1944615747144 1.20736094219385e-16 MirTarget;miRNATAP -0.262146143655721 0.00019470100533496 NA NA NA hsa-let-7f-2-3p WWTR1 1.02768112108475 0.0787293499732611 -0.435456131620842 0.479573959882984 MirTarget -0.165807010815473 0.00674765852201001 NA NA NA hsa-miR-142-5p WWTR1 3.95552531913424 1.49536283724079e-08 -0.435456131620842 0.479573959882984 mirMAP -0.159347147459698 0.00104303623289687 NA NA NA hsa-miR-155-5p WWTR1 2.81443182173772 7.42530504828797e-05 -0.435456131620842 0.479573959882984 mirMAP -0.271267469269084 1.18678551326971e-08 NA NA NA hsa-miR-29a-3p WWTR1 -0.638239697975974 0.251923581881716 -0.435456131620842 0.479573959882984 miRNATAP -0.20849539246533 0.000882008925432056 NA NA NA hsa-miR-29a-5p WWTR1 0.0748295222568571 0.884125894063293 -0.435456131620842 0.479573959882984 mirMAP -0.197039467528872 0.00395271050175627 NA NA NA hsa-miR-29b-3p WWTR1 0.666547117072858 0.234055379278093 -0.435456131620842 0.479573959882984 miRNATAP -0.274199625269075 9.46082250679152e-06 NA NA NA hsa-miR-3065-5p WWTR1 2.14185373842821 0.0609400502269891 -0.435456131620842 0.479573959882984 mirMAP -0.108518571158706 0.00416782096776822 NA NA NA hsa-miR-30e-5p WWTR1 0.780047227271616 0.0346714425913016 -0.435456131620842 0.479573959882984 MirTarget -0.327058912118531 0.000618967799894357 NA NA NA hsa-miR-511-5p WWTR1 1.10428503984162 0.179276103915417 -0.435456131620842 0.479573959882984 MirTarget -0.110700004682706 0.00908972618185537 NA NA NA hsa-miR-590-3p WWTR1 2.35429565068338 2.79601879608564e-06 -0.435456131620842 0.479573959882984 MirTarget;miRanda;mirMAP -0.246326043970428 0.000316718738517735 NA NA NA hsa-miR-200a-3p YAP1 6.336081120041 4.024313571871e-16 -0.717460133341563 0.36094816300211 miRNAWalker2_validate;MirTarget -0.205369128575749 0.000140866111002424 23340296 MicroRNA 200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer; We identified Yes-associated protein 1 YAP1 as a novel target of miR-200a; Our data showed that targeting of YAP1 by miR-200a resulted in decreased expression of proapoptotic proteins which leads to anoikis resistance; Remarkably we found that YAP1 expression was inversely correlated with miR-200a expression in breast cancer clinical specimens and miR-200a expression was associated with distant metastasis in patients with breast cancer metastasis;drug resistance breast cancer hsa-miR-200b-3p YAP1 5.56167217794639 6.43540045061709e-16 -0.717460133341563 0.36094816300211 MirTarget -0.294415125862106 1.23893734345189e-06 NA NA NA hsa-miR-361-3p YAP1 0.805698609170807 0.0418491665498322 -0.717460133341563 0.36094816300211 MirTarget;PITA -0.485841481714406 1.65267663819174e-05 NA NA NA hsa-miR-375 YAP1 3.3784490463318 0.0449946294355695 -0.717460133341563 0.36094816300211 miRNAWalker2_validate;miRTarBase;miRNATAP -0.126743625845637 9.70787394257508e-07 27270433;23685355;20226166;21856745 A ZEB1 miR 375 YAP1 pathway regulates epithelial plasticity in prostate cancer; The transcription factor YAP1 was found to be a direct target of miR-375 in prostate cancer; Knockdown of YAP1 phenocopied miR-375 overexpression and overexpression of YAP1 rescued anti-invasive effects mediated by miR-375;Overexpression of miR 10a and miR 375 and downregulation of YAP1 in medullary thyroid carcinoma; Expression of the potential downstream targets of miR-375 YAP1 a growth inhibitor and SLC16a2 a transporter of thyroid hormone was down-regulated in the tumors suggesting that miR-375 is a negative regulator of the expression of these genes; Furthermore the growth inhibitor YAP1 is identified as a potential important downstream target of miR-375;MicroRNA 375 targets Hippo signaling effector YAP in liver cancer and inhibits tumor properties; The present study aims to elucidate the transcriptional regulation of YAP targeted by microRNA miRNA miR-375 is a putative target and was found significantly down-regulated in the tumor versus adjacent non-tumor tissues of HCC patients n=48; As determined by luciferase reporter assay we found ectopic expression of miR-375 could diminish the transcriptional activity of YAP; Furthermore immunoblotting revealed miR-375 suppressed endogenous YAP protein level; miR-375 is an important regulator of YAP oncogene implicating a potential therapeutic role in HCC treatment;miR 375 is activated by ASH1 and inhibits YAP1 in a lineage dependent manner in lung cancer; The transcriptional coactivator YAP1 was determined to be a direct target of miR-375; YAP1 showed a negative correlation with miR-375 in a panel of lung cancer cell lines and growth inhibitory activities in NE-lung cancer cells ;;; prostate cancer;thyroid cancer;liver cancer;lung cancer hsa-miR-429 YAP1 6.39965293994036 1.96920201593608e-18 -0.717460133341563 0.36094816300211 MirTarget;miRanda -0.203834909340598 0.000360910199570488 NA NA NA hsa-miR-532-5p YAP1 -0.297424983759107 0.503934707453099 -0.717460133341563 0.36094816300211 PITA -0.335342512766707 0.000881077760633327 NA NA NA hsa-miR-181c-5p YWHAB -0.302833440762172 0.537532549455539 0.335869051616385 0.183059097452288 mirMAP -0.125689817265884 1.28469508387139e-05 NA NA NA hsa-miR-181c-5p YWHAG -0.302833440762172 0.537532549455539 0.385447226562581 0.259836541396253 MirTarget;miRNATAP -0.154303477041672 8.85668622972177e-05 NA NA NA hsa-miR-200a-3p YWHAG 6.336081120041 4.024313571871e-16 0.385447226562581 0.259836541396253 MirTarget;miRNATAP -0.102315490044077 1.13196642995869e-05 NA NA NA hsa-miR-200b-3p YWHAG 5.56167217794639 6.43540045061709e-16 0.385447226562581 0.259836541396253 MirTarget;TargetScan -0.11446043266416 1.4853090925883e-05 NA NA NA hsa-miR-30a-5p YWHAG -0.768430903969183 0.320487552854215 0.385447226562581 0.259836541396253 miRNATAP -0.121044963221771 8.71646064734457e-07 NA NA NA hsa-miR-361-3p YWHAG 0.805698609170807 0.0418491665498322 0.385447226562581 0.259836541396253 miRNATAP -0.158816170102406 0.00125725402796885 NA NA NA hsa-miR-103a-3p YWHAH 0.990919087251708 0.00468308601422847 0.13374017455715 0.582343790497203 miRNAWalker2_validate;MirTarget;miRNATAP -0.118934118915957 0.00255872843635267 NA NA NA hsa-miR-125a-5p YWHAZ -1.32352790615388 0.00714301627309467 0.79320742951499 0.0165264552158362 miRanda -0.201268409816025 8.09227898128116e-08 NA NA NA hsa-miR-140-3p YWHAZ -1.9828800596692 8.92876132959514e-08 0.79320742951499 0.0165264552158362 MirTarget;PITA;miRNATAP -0.209328588960889 2.6752974302612e-05 NA NA NA hsa-miR-186-5p YWHAZ 0.445443449112564 0.185447310527704 0.79320742951499 0.0165264552158362 mirMAP -0.186541881236864 0.00102158968605537 NA NA NA hsa-miR-195-3p YWHAZ -2.39100534119332 0.000185405399054065 0.79320742951499 0.0165264552158362 MirTarget -0.10349718609516 0.00037684292135237 NA NA NA hsa-miR-28-5p YWHAZ -0.815636722979196 0.0221199948901761 0.79320742951499 0.0165264552158362 PITA;miRanda;miRNATAP -0.246603493589959 3.00364263847771e-06 NA NA NA hsa-miR-30a-5p YWHAZ -0.768430903969183 0.320487552854215 0.79320742951499 0.0165264552158362 miRNAWalker2_validate;MirTarget;miRNATAP -0.114377769916144 1.71880952710236e-06 NA NA NA hsa-miR-328-3p YWHAZ -0.405365328300136 0.434443269076833 0.79320742951499 0.0165264552158362 MirTarget -0.13309401279703 0.000234142058366856 NA NA NA hsa-miR-3913-5p YWHAZ 0.145645056779437 0.734844256690741 0.79320742951499 0.0165264552158362 MirTarget -0.204232871287809 2.79795865642911e-06 NA NA NA hsa-miR-7-1-3p YWHAZ 1.43074343339835 0.00471215970502094 0.79320742951499 0.0165264552158362 mirMAP -0.120732639494573 0.00108325254319048 NA NA NA