miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-106a-5p	TGFBR2	1.3902608059488	6.07931522284525e-05	-1.91514811101753	8.06244385153145e-21	miRTarBase;miRNATAP	-0.307299619778838	1.05077186229689e-24	22912877	MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion	cell migration	colorectal cancer
hsa-miR-106b-5p	TGFBR2	1.47447672652218	1.32004094930462e-13	-1.91514811101753	8.06244385153145e-21	miRNATAP	-0.489829180282667	8.40946965796872e-27		NA	NA	NA
hsa-miR-107	TGFBR2	0.658676029898313	5.11480446318819e-07	-1.91514811101753	8.06244385153145e-21	miRanda;miRNATAP	-0.249662024836709	0.000915438458167535		NA	NA	NA
hsa-miR-130a-3p	TGFBR2	0.881660100597014	0.000158893668519248	-1.91514811101753	8.06244385153145e-21	miRNATAP	-0.133524786080657	0.00147048710917249		NA	NA	NA
hsa-miR-130b-3p	TGFBR2	1.83046548750752	5.04753914574694e-13	-1.91514811101753	8.06244385153145e-21	miRNAWalker2_validate;miRNATAP	-0.421734905263531	3.34337229820852e-29	25024357	Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC		lung squamous cell cancer
hsa-miR-142-3p	TGFBR2	3.98476449801341	1.56256182021111e-35	-1.91514811101753	8.06244385153145e-21	miRanda	-0.187481539830466	1.6656456255275e-11		NA	NA	NA
hsa-miR-17-5p	TGFBR2	2.07078488653279	2.77403038572568e-19	-1.91514811101753	8.06244385153145e-21	miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP	-0.459908602342412	2.77212111529676e-33	25011053;27120811	We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer	;	kidney renal cell cancer;gastric cancer
hsa-miR-186-5p	TGFBR2	0.852175445703945	6.88885738584309e-10	-1.91514811101753	8.06244385153145e-21	miRNATAP	-0.37798394554975	7.20570520945192e-08		NA	NA	NA
hsa-miR-18a-5p	TGFBR2	1.37435209536521	9.2173853686829e-06	-1.91514811101753	8.06244385153145e-21	miRNAWalker2_validate	-0.38653356233861	4.47853283994857e-34		NA	NA	NA
hsa-miR-19a-3p	TGFBR2	2.11776595911517	7.07663078397156e-10	-1.91514811101753	8.06244385153145e-21	miRNAWalker2_validate;miRNATAP	-0.323482765468371	5.08943605092696e-24		NA	NA	NA
hsa-miR-19b-3p	TGFBR2	2.10868505662119	5.40846613768389e-17	-1.91514811101753	8.06244385153145e-21	miRNAWalker2_validate;miRNATAP	-0.328250904264368	1.63625661417425e-17		NA	NA	NA
hsa-miR-20a-5p	TGFBR2	2.64649625616975	5.1469418982085e-27	-1.91514811101753	8.06244385153145e-21	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.375686915628948	1.07150885156846e-25		NA	NA	NA
hsa-miR-20b-5p	TGFBR2	1.35770573270947	0.00260808530013016	-1.91514811101753	8.06244385153145e-21	miRNATAP	-0.192278018490753	3.46305290056928e-18		NA	NA	NA
hsa-miR-21-5p	TGFBR2	4.38165933891779	1.52536633902505e-92	-1.91514811101753	8.06244385153145e-21	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.29338269527103	7.25339608661878e-16	24037531	Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway		prostate cancer
hsa-miR-28-5p	TGFBR2	1.19639196514745	4.59365801666536e-18	-1.91514811101753	8.06244385153145e-21	miRanda	-0.254315455087218	0.000247518782921618		NA	NA	NA
hsa-miR-301a-3p	TGFBR2	2.70198002906399	1.56420889710984e-14	-1.91514811101753	8.06244385153145e-21	miRNATAP	-0.306940704751146	1.9075182777364e-21	25551793	MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2		colorectal cancer
hsa-miR-320b	TGFBR2	0.226640952564488	0.378818692487242	-1.91514811101753	8.06244385153145e-21	miRanda;miRNATAP	-0.165151125825337	1.46846956764834e-05		NA	NA	NA
hsa-miR-335-3p	TGFBR2	1.51116383169018	6.88553098788624e-13	-1.91514811101753	8.06244385153145e-21	mirMAP	-0.311492404920043	3.63496852087191e-12		NA	NA	NA
hsa-miR-429	TGFBR2	2.3794516574089	1.72813419703734e-13	-1.91514811101753	8.06244385153145e-21	miRNATAP	-0.181653865770588	1.06914381055553e-08		NA	NA	NA
hsa-miR-454-3p	TGFBR2	1.49453641052169	4.46235742871434e-09	-1.91514811101753	8.06244385153145e-21	miRNATAP	-0.388080867072043	1.00998271677092e-18		NA	NA	NA
hsa-miR-590-3p	TGFBR2	0.83851360565783	0.00129224433453587	-1.91514811101753	8.06244385153145e-21	miRanda	-0.298621103008163	1.65211510727765e-11		NA	NA	NA
hsa-miR-590-5p	TGFBR2	2.07441240363458	4.95240551694843e-14	-1.91514811101753	8.06244385153145e-21	miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP	-0.431767389541112	5.30215312039448e-26		NA	NA	NA
hsa-miR-9-5p	TGFBR2	4.99250901331516	2.59132733422801e-19	-1.91514811101753	8.06244385153145e-21	miRNATAP	-0.172577947355941	5.13696472146911e-27	25024357	Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC		lung squamous cell cancer
hsa-miR-92a-3p	TGFBR2	-0.136362762339122	0.493412263619364	-1.91514811101753	8.06244385153145e-21	miRNAWalker2_validate	-0.23924023089002	1.25343457467846e-06		NA	NA	NA
hsa-miR-93-5p	TGFBR2	1.50844106515467	1.83836866996875e-12	-1.91514811101753	8.06244385153145e-21	miRNAWalker2_validate;miRNATAP	-0.466353393701927	4.52770573714137e-28		NA	NA	NA