miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-223-3p	ACSL3	-0.966406159689943	7.90612601654887e-12	0.179317006023102	0.0415944883042152	MirTarget	-0.142448011956012	8.30082185447854e-12		NA	NA	NA
hsa-miR-223-3p	ADCY1	-0.966406159689943	7.90612601654887e-12	-0.0486801025784516	0.841490665662841	mirMAP	-0.37644646227746	6.97975343073825e-11		NA	NA	NA
hsa-miR-223-3p	ADM2	-0.966406159689943	7.90612601654887e-12	2.40773160906737	2.14684505542733e-54	mirMAP	-0.156186998175809	8.41559206167778e-05		NA	NA	NA
hsa-miR-223-3p	ALCAM	-0.966406159689943	7.90612601654887e-12	0.50501413295289	0.00106417407883302	MirTarget	-0.287942934306869	2.97926859342895e-15		NA	NA	NA
hsa-miR-223-3p	ANTXR1	-0.966406159689943	7.90612601654887e-12	-0.175157280636024	0.169834470022929	mirMAP	-0.11234423637241	0.000232534695546254		NA	NA	NA
hsa-miR-223-3p	AR	-0.966406159689943	7.90612601654887e-12	-0.998221110404377	0.000935519021681841	mirMAP	-0.551553733872348	1.13238598579906e-14	21453483	miR 223 regulates migration and invasion by targeting Artemin in human esophageal carcinoma; To develop potential therapy targeting ARTN we studied the roles of miR-223 in the migration and invasion of human esophageal carcinoma; ARTN mRNA contains a binding site for miR-223 in the 3'UTR; Co-transfection of a mir-223 expression vector with pMIR-ARTN led to the reduced activity of luciferase in a dual-luciferase reporter gene assay suggesting that ARTN is a target gene of miR-223; Overexpression of miR-223 decreased expression of ARTN in KYSE150 cells while silencing miR-223 increased expression of ARTN in EC9706 cells; These results reveal that ARTN a known tumor metastasis-related gene is a direct target of miR-223 and that miR-223 may have a tumor suppressor function in esophageal carcinoma and could be used in anticancer therapies	metastasis	esophageal cancer
hsa-miR-223-3p	ARTN	-0.966406159689943	7.90612601654887e-12	3.03715126666455	3.08864896532778e-43	miRNAWalker2_validate;miRTarBase	-0.155063436723059	0.00542977198240274	21453483	miR 223 regulates migration and invasion by targeting Artemin in human esophageal carcinoma; To develop potential therapy targeting ARTN we studied the roles of miR-223 in the migration and invasion of human esophageal carcinoma; ARTN mRNA contains a binding site for miR-223 in the 3'UTR; Co-transfection of a mir-223 expression vector with pMIR-ARTN led to the reduced activity of luciferase in a dual-luciferase reporter gene assay suggesting that ARTN is a target gene of miR-223; Overexpression of miR-223 decreased expression of ARTN in KYSE150 cells while silencing miR-223 increased expression of ARTN in EC9706 cells; These results reveal that ARTN a known tumor metastasis-related gene is a direct target of miR-223 and that miR-223 may have a tumor suppressor function in esophageal carcinoma and could be used in anticancer therapies	metastasis	esophageal cancer
hsa-miR-223-3p	ATP7A	-0.966406159689943	7.90612601654887e-12	-0.473678749038493	2.42759355063231e-07	MirTarget	-0.151155395417743	4.8087849807502e-12		NA	NA	NA
hsa-miR-223-3p	CBX5	-0.966406159689943	7.90612601654887e-12	0.00412285731163831	0.953838036024806	MirTarget	-0.127825899255391	2.59886882289471e-14		NA	NA	NA
hsa-miR-223-3p	CCDC96	-0.966406159689943	7.90612601654887e-12	0.927165602067302	5.32450420885982e-13	MirTarget	-0.235266696775697	2.11492920394617e-14		NA	NA	NA
hsa-miR-223-3p	CDK17	-0.966406159689943	7.90612601654887e-12	-0.124778185173291	0.119991532413407	MirTarget	-0.136477707609656	6.21361190778804e-13		NA	NA	NA
hsa-miR-223-3p	CXXC4	-0.966406159689943	7.90612601654887e-12	-0.348454370147505	0.0800945501479367	MirTarget	-0.339412266927715	5.92753918193085e-13		NA	NA	NA
hsa-miR-223-3p	DDI2	-0.966406159689943	7.90612601654887e-12	-0.874948299770357	1.36141202726123e-06	mirMAP	-0.136703052967594	0.00174327983459004		NA	NA	NA
hsa-miR-223-3p	E2F1	-0.966406159689943	7.90612601654887e-12	2.60062333464716	6.00545189391833e-64	miRNAWalker2_validate;miRTarBase	-0.143216930870757	0.000341168021306422	20029046	Cell cycle regulator E2F1 and microRNA 223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia; In this report we demonstrate that during granulopoiesis microRNA-223 targets E2F1; E2F1 protein was up-regulated in miR-223 null mice; Our study supports a molecular network involving miR-223 C/EBPalpha and E2F1 as major components of the granulocyte differentiation program which is deregulated in AML	differentiation	acute myeloid leukemia
hsa-miR-223-3p	ECT2	-0.966406159689943	7.90612601654887e-12	1.65478701031364	1.56744233875072e-49	MirTarget	-0.176341362300476	4.436061745621e-10	24784921;23601845	MicroRNA-223 miR-223 has been demonstrated to be implicated in cell proliferation and cell cycle progression of osteosarcoma cell lines by regulating its target gene epithelial cell transforming sequence 2 ECT2; To address this problem we firstly showed that the expression levels of miR-223 and Ect2 messenger RNA were respectively down-regulated and up-regulated in osteosarcoma tissues compared with those in noncancerous bone tissues significantly both P < .001 according to the results of quantitative real-time reverse transcription-polymerase chain reaction; Notably miR-223 down-regulation was negatively correlated with Ect2 messenger RNA up-regulation in osteosarcoma tissues r = -0.68 P = .01; Then the combined low miR-223 expression and high Ect2 expression miR-223-low/Ect2-high was significantly associated with high tumor grade P = .01 poor response to chemotherapy P = .01 positive metastasis P < .001 and recurrence P < .001 of osteosarcomas; In conclusion our data offer convincing evidence that the deregulation of miR-223 and its target gene ECT2 may be associated with the aggressive tumor progression of human osteosarcoma; Of note the combined miR-223 down-regulation and Ect2 up-regulation may be a possible marker of poor prognosis in this malignancy;Further mechanistic study indicated that Ect2 was directly targeted by miR-223; Downregulation of Ect2 by miR-223 induces the expression of p21 p27 and the phospharylation of retinoblastoma which are involved in the G1 block	progression;metastasis;recurrence;drug resistance;worse prognosis;	sarcoma;sarcoma
hsa-miR-223-3p	FAM199X	-0.966406159689943	7.90612601654887e-12	0.253187015339215	0.000942799939057211	MirTarget	-0.156075531564389	4.53567798175705e-18		NA	NA	NA
hsa-miR-223-3p	GABRB2	-0.966406159689943	7.90612601654887e-12	-0.410754996976047	0.0586351088118814	mirMAP	-0.308843136544981	2.27083375581809e-09		NA	NA	NA
hsa-miR-223-3p	GLYR1	-0.966406159689943	7.90612601654887e-12	0.47781670452108	1.12356863971707e-16	mirMAP	-0.107428021136407	8.10736783782077e-15		NA	NA	NA
hsa-miR-223-3p	HARBI1	-0.966406159689943	7.90612601654887e-12	0.67436230230856	1.68720606459204e-31	MirTarget	-0.116963459265681	1.10353312247426e-16		NA	NA	NA
hsa-miR-223-3p	HOOK1	-0.966406159689943	7.90612601654887e-12	1.26824245301338	3.73818356198544e-20	MirTarget	-0.337812458447522	1.00848165001507e-24		NA	NA	NA
hsa-miR-223-3p	IGF1R	-0.966406159689943	7.90612601654887e-12	0.118209603036572	0.482168850037006	miRNAWalker2_validate;miRTarBase;MirTarget	-0.327294415285608	1.36068714681003e-16		NA	NA	NA
hsa-miR-223-3p	IL6ST	-0.966406159689943	7.90612601654887e-12	-1.52737235369582	4.44388978309665e-09	MirTarget	-0.223794440219529	0.00037556461069345		NA	NA	NA
hsa-miR-223-3p	IPO9	-0.966406159689943	7.90612601654887e-12	0.553239220279916	7.61322298585656e-21	mirMAP	-0.112697948485731	2.62298207399438e-15		NA	NA	NA
hsa-miR-223-3p	IQCE	-0.966406159689943	7.90612601654887e-12	0.738559609175382	4.11450157120893e-24	mirMAP	-0.105925195544253	2.81417593027606e-09		NA	NA	NA
hsa-miR-223-3p	KCNC1	-0.966406159689943	7.90612601654887e-12	-0.419819323532828	0.125779819998908	mirMAP	-0.267289941378432	4.58320707309729e-05		NA	NA	NA
hsa-miR-223-3p	KCND3	-0.966406159689943	7.90612601654887e-12	-1.6472717356446	2.67019410294081e-09	mirMAP	-0.183368698174197	0.006224263218005		NA	NA	NA
hsa-miR-223-3p	KSR2	-0.966406159689943	7.90612601654887e-12	-0.0859402107200666	0.658608084265407	mirMAP	-0.37513075786898	2.57999985323648e-16		NA	NA	NA
hsa-miR-223-3p	LRIG1	-0.966406159689943	7.90612601654887e-12	-0.621746524290395	6.21466939887491e-08	MirTarget	-0.189470497293933	4.8436993060658e-12		NA	NA	NA
hsa-miR-223-3p	MAP3K9	-0.966406159689943	7.90612601654887e-12	0.50088479523049	3.0542807284228e-05	mirMAP	-0.145902173609862	3.92327902151058e-07		NA	NA	NA
hsa-miR-223-3p	MARCH10	-0.966406159689943	7.90612601654887e-12	1.81615229521554	6.74660171168223e-16	MirTarget	-0.463296745782067	7.93878923447683e-18		NA	NA	NA
hsa-miR-223-3p	MMP16	-0.966406159689943	7.90612601654887e-12	-0.481934192325192	0.0113040399956389	mirMAP	-0.20255580748097	8.52354762330963e-06		NA	NA	NA
hsa-miR-223-3p	MTSS1	-0.966406159689943	7.90612601654887e-12	0.269937976301368	0.0225526277467935	MirTarget	-0.17718851585106	2.9382041817857e-10		NA	NA	NA
hsa-miR-223-3p	NIPA1	-0.966406159689943	7.90612601654887e-12	0.387103029668829	3.43331510267279e-06	mirMAP	-0.150951968715582	2.32310306797006e-14		NA	NA	NA
hsa-miR-223-3p	NUP210	-0.966406159689943	7.90612601654887e-12	2.09636622115365	4.65070854679666e-75	MirTarget	-0.188044352795507	3.03110641051288e-10		NA	NA	NA
hsa-miR-223-3p	PARD6B	-0.966406159689943	7.90612601654887e-12	1.70997497031339	2.55366919190462e-20	MirTarget	-0.436848323089214	6.10174627335383e-23		NA	NA	NA
hsa-miR-223-3p	PARP1	-0.966406159689943	7.90612601654887e-12	1.13971259332431	1.69330870975379e-63	miRNAWalker2_validate	-0.115710425992834	2.83386237820155e-11		NA	NA	NA
hsa-miR-223-3p	PTPRT	-0.966406159689943	7.90612601654887e-12	-0.922018035462999	0.0136915437550837	mirMAP	-0.414885254414827	3.48435666703884e-06		NA	NA	NA
hsa-miR-223-3p	RAB11FIP4	-0.966406159689943	7.90612601654887e-12	1.53441164799704	3.50928776989217e-42	mirMAP	-0.238576477754577	1.37999138596446e-17		NA	NA	NA
hsa-miR-223-3p	RALGPS1	-0.966406159689943	7.90612601654887e-12	0.320371955401898	0.000743623076739109	mirMAP	-0.241229707100602	8.6767641818247e-28		NA	NA	NA
hsa-miR-223-3p	RALGPS2	-0.966406159689943	7.90612601654887e-12	0.889426971470516	5.63881052160942e-09	MirTarget	-0.327146408124573	1.37699315861063e-19		NA	NA	NA
hsa-miR-223-3p	RASA1	-0.966406159689943	7.90612601654887e-12	-0.294730586920749	0.000766494242183886	MirTarget	-0.105611829493872	4.47427896765755e-07	25867276	C/EBP β activated microRNA 223 promotes tumour growth through targeting RASA1 in human colorectal cancer; The levels of RASA1 and miR-223 were analysed by real-time PCR western blotting or in situ immunofluorescence analyses; Upregulation of miR-223 was detected in CRC tissues P<0.01 and was involved in downregulation of RASA1 in CRC tissues; Furthermore the direct inhibition of RASA1 translation by miR-223 and the activation of miR-223 by CCAAT/enhancer binding protein-β C/EBP-β were evaluated in CRC cells; These results identify that C/EBP-β-activated miR-223 contributes to tumour growth by targeting RASA1 in CRC and miR-223-targeted inhibitors may have clinical promise for CRC treatment via suppression of miR-223		colorectal cancer
hsa-miR-223-3p	RERG	-0.966406159689943	7.90612601654887e-12	-0.475322037527984	0.0125011664976752	MirTarget	-0.32350277425887	7.26182165864138e-13		NA	NA	NA
hsa-miR-223-3p	RHOB	-0.966406159689943	7.90612601654887e-12	-0.173913833425914	0.148250631072104	miRNAWalker2_validate;miRTarBase;MirTarget	-0.119176738495152	3.38023083702322e-05		NA	NA	NA
hsa-miR-223-3p	RIBC1	-0.966406159689943	7.90612601654887e-12	1.02825222594949	3.24338701300761e-13	MirTarget	-0.328265154313993	1.02420021031244e-22		NA	NA	NA
hsa-miR-223-3p	RNF14	-0.966406159689943	7.90612601654887e-12	-0.0242436974864582	0.67604881629632	MirTarget	-0.132898207160818	7.43219344129605e-23		NA	NA	NA
hsa-miR-223-3p	RPS6KB1	-0.966406159689943	7.90612601654887e-12	-0.0571936206706596	0.498093695192352	MirTarget	-0.140401561003547	1.98539879754319e-12		NA	NA	NA
hsa-miR-223-3p	SAMD12	-0.966406159689943	7.90612601654887e-12	0.749718148942251	7.14387599251026e-08	mirMAP	-0.255772350271162	1.11132322386728e-14		NA	NA	NA
hsa-miR-223-3p	SLC1A2	-0.966406159689943	7.90612601654887e-12	0.459709222651274	0.0428564210643349	mirMAP	-0.46088223368922	6.06622653206677e-18		NA	NA	NA
hsa-miR-223-3p	SLC46A1	-0.966406159689943	7.90612601654887e-12	-0.307984314207807	0.00250539082651516	mirMAP	-0.187039070948198	8.06920692173499e-15		NA	NA	NA
hsa-miR-223-3p	SRP54	-0.966406159689943	7.90612601654887e-12	0.593964192103022	6.0275181510281e-22	MirTarget	-0.167462719493301	2.06954648568698e-30		NA	NA	NA
hsa-miR-223-3p	SSBP2	-0.966406159689943	7.90612601654887e-12	-0.688186904830189	6.78722403001534e-13	MirTarget	-0.114802633471765	7.21255065077602e-07		NA	NA	NA
hsa-miR-223-3p	STK39	-0.966406159689943	7.90612601654887e-12	0.351305258160079	0.00163274156159164	MirTarget	-0.139821336687857	1.50905352003632e-07		NA	NA	NA
hsa-miR-223-3p	TRIL	-0.966406159689943	7.90612601654887e-12	-0.0892565511310854	0.493473726377878	MirTarget	-0.184561043662425	2.51719621575422e-09		NA	NA	NA
hsa-miR-223-3p	TWF1	-0.966406159689943	7.90612601654887e-12	0.306176907876321	8.96403066688567e-06	MirTarget	-0.141729951864479	2.77522840336329e-18		NA	NA	NA
hsa-miR-223-3p	UBE2W	-0.966406159689943	7.90612601654887e-12	0.22166426350523	0.00400548554178369	mirMAP	-0.115635095633885	2.61574790521006e-10		NA	NA	NA
hsa-miR-223-3p	UBR5	-0.966406159689943	7.90612601654887e-12	-0.0736498642926824	0.359547805631344	MirTarget	-0.10350012878783	6.13603514768966e-08		NA	NA	NA
hsa-miR-223-3p	ULK2	-0.966406159689943	7.90612601654887e-12	-0.375958333211797	2.89189077422925e-05	MirTarget	-0.122867487138845	1.04589382185593e-08		NA	NA	NA
hsa-miR-223-3p	VPS13B	-0.966406159689943	7.90612601654887e-12	-0.128944693117492	0.174938119035302	mirMAP	-0.153653787916796	8.6543748788781e-12		NA	NA	NA
hsa-miR-223-3p	VPS52	-0.966406159689943	7.90612601654887e-12	0.406602835001217	1.24226990211339e-16	mirMAP	-0.110427082322606	3.11570022326316e-21		NA	NA	NA
hsa-miR-223-3p	WDR26	-0.966406159689943	7.90612601654887e-12	0.211189332597961	0.000367879099017822	mirMAP	-0.118768940608264	1.68657107162492e-17		NA	NA	NA
hsa-miR-223-3p	XPR1	-0.966406159689943	7.90612601654887e-12	0.227284344019749	0.00588366813164452	MirTarget	-0.118171769124486	1.7239914298569e-09		NA	NA	NA
hsa-miR-223-3p	ZFHX3	-0.966406159689943	7.90612601654887e-12	-0.348999974902257	0.000181853915066663	MirTarget	-0.198763828185815	1.24114391547981e-19		NA	NA	NA
hsa-miR-223-3p	ZNF365	-0.966406159689943	7.90612601654887e-12	0.544881298195121	0.000430082423527048	MirTarget	-0.172152612704514	3.38294146589203e-06		NA	NA	NA
hsa-miR-223-3p	ZNF587	-0.966406159689943	7.90612601654887e-12	0.617628823146323	1.14296232137843e-07	mirMAP	-0.27686077087882	4.45081450321334e-24		NA	NA	NA
hsa-miR-223-3p	ZNF772	-0.966406159689943	7.90612601654887e-12	-0.233166635600139	0.049687043136847	MirTarget	-0.128343827275609	6.08807597238089e-06		NA	NA	NA