miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-5p AIFM1 0.161665753874088 0.927771425476349 -0.0506120918999766 0.945184502455657 miRNATAP -0.161261245245166 0.000699421266431265 NA NA NA hsa-miR-106a-5p AKT3 -0.187436837607903 0.776596826979526 0.199831583262608 0.649870795681386 miRNATAP -0.122915747534173 0.0211707835743014 NA NA NA hsa-miR-106b-5p AKT3 -0.114223082397499 0.918147136717927 0.199831583262608 0.649870795681386 miRNATAP -0.411504731855899 9.49650030459631e-06 NA NA NA hsa-miR-142-3p AKT3 0.0379334054800466 0.978238829636286 0.199831583262608 0.649870795681386 miRanda -0.161022651130634 0.00933730307368185 NA NA NA hsa-miR-15a-5p AKT3 -0.00791539523924278 0.993533724178566 0.199831583262608 0.649870795681386 miRNAWalker2_validate;miRTarBase;miRNATAP -0.374578960806042 0.000213935533400346 NA NA NA hsa-miR-15b-5p AKT3 0.00885606323496901 0.993510047034825 0.199831583262608 0.649870795681386 miRNATAP -0.254367737995205 0.00570754876367863 NA NA NA hsa-miR-16-5p AKT3 0.00657489810438072 0.99567095250359 0.199831583262608 0.649870795681386 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309870666150618 0.000864570425925272 NA NA NA hsa-miR-17-5p AKT3 -0.000596233219692266 0.999589719956144 0.199831583262608 0.649870795681386 TargetScan;miRNATAP -0.174632371966135 0.0291369962045925 NA NA NA hsa-miR-29b-2-5p AKT3 0.0506576777608494 0.914446526694261 0.199831583262608 0.649870795681386 mirMAP -0.233312651843654 0.0174700497895885 NA NA NA hsa-miR-29b-3p AKT3 0.142303641653058 0.900102271992252 0.199831583262608 0.649870795681386 miRNATAP -0.283935483475042 0.000311340903637634 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 -0.318966306994077 0.311417121022653 0.199831583262608 0.649870795681386 mirMAP -0.221762461081726 2.87831776854007e-06 NA NA NA hsa-miR-362-3p AKT3 0.080128943742904 0.76325400634285 0.199831583262608 0.649870795681386 miRanda -0.254988730314174 0.00123561088951897 NA NA NA hsa-miR-501-3p AKT3 -0.213232934691677 0.749134059424389 0.199831583262608 0.649870795681386 miRNATAP -0.18288683695833 0.00732967244086728 NA NA NA hsa-miR-502-3p AKT3 -0.0742971274545239 0.863623336074792 0.199831583262608 0.649870795681386 miRNATAP -0.229135660673546 0.0306493790797631 NA NA NA hsa-miR-93-5p AKT3 -0.103495149722972 0.948829359383178 0.199831583262608 0.649870795681386 miRNATAP -0.334744595445174 0.000214241376596223 NA NA NA hsa-miR-155-5p APAF1 0.150755193213955 0.894622203994624 0.0477241419313028 0.936432778063845 miRNAWalker2_validate -0.105119871128062 0.000202319072259625 22996741;26877850 MiR 155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf 1 expression; The objective of this study is to verify the hypothesis based on the results of bioinformatics analysis that miR-155 modulates cellular apoptosis and DNA damage through the regulation of Apaf-1 and is thus involved in the development and progression of lung cancer; First we measured the expression of miR-155 and the Apaf-1 protein in lung cancer tissues; The results showed that expression of miR-155 was significantly higher in lung cancer tissues than in paracancerous and normal tissues; whereas Apaf-1 expression was lower in the lung cancerous tissues; The results showed that relative to controls the silencing of miR-155 resulted in elevated expression of the Apaf-1 protein whereas Apaf-1 mRNA levels remained unchanged; Both the silencing of miR-155 and the overexpression Apaf-1 greatly increased the sensitivity of A549 cells to cisplatin treatment as evidenced by elevated rates of apoptosis and DNA damage; Furthermore dual-transfection of A549 cells with miR-155 siRNA and Apaf-1 siRNA resulted in the attenuation of apoptosis and DNA damage;Also increase in the transcript level of APAF-1 and CASP-9 after downregulation of miR-21 and miR-155 might indicate that these genes were targeted by aforementioned miRNAs in T47D cells progression; lung cancer;breast cancer hsa-miR-23a-3p APAF1 -0.000919962616247716 0.999510817457789 0.0477241419313028 0.936432778063845 miRNATAP -0.249229585742285 6.24449355106243e-06 24992592;24249161 Luciferase assay was performed to verify a putative target site of miR-23a in the 3'-UTR of apoptosis protease activating factor 1 APAF1 mRNA; The expression levels of miR-23a and APAF1 in CRC cell lines SW480 and SW620 and clinical samples were assessed using reverse transcription-quantitative real-time PCR RT-qPCR and Western blot; Moreover miR-23a up-regulation was coupled with APAF1 down-regulation in CRC tissue samples;We found that the expression of miR-23a was increased and the level of apoptosis-activating factor-1 APAF-1 was decreased in 5-FU-treated colon cancer cells compared to untreated cells; APAF-1 as a target gene of miR-23a was identified and miR-23a antisense-induced increase in the activation of caspase-9 was observed ; colorectal cancer;colorectal cancer hsa-miR-23b-3p APAF1 -0.0423426775157463 0.974391918147413 0.0477241419313028 0.936432778063845 miRNATAP -0.161636616309506 0.000480979993890262 NA NA NA hsa-miR-27a-3p APAF1 0.089292677549258 0.950107084866822 0.0477241419313028 0.936432778063845 miRNATAP -0.178590051704588 2.61315263276561e-05 NA NA NA hsa-miR-27b-3p APAF1 -0.0443985093857169 0.975274873214159 0.0477241419313028 0.936432778063845 miRNATAP -0.157888261033241 5.61389496165659e-05 NA NA NA hsa-miR-374b-5p APAF1 -0.120825593958128 0.872556407127498 0.0477241419313028 0.936432778063845 mirMAP -0.131472896885655 0.0153106888263216 NA NA NA hsa-miR-590-3p APAF1 -0.139003976504018 0.700453857398655 0.0477241419313028 0.936432778063845 PITA;miRanda;mirMAP;miRNATAP -0.117753147962954 0.00340114353110643 NA NA NA hsa-miR-590-5p APAF1 -0.173775001452706 0.734742724035795 0.0477241419313028 0.936432778063845 miRanda -0.101026476650395 0.0138258431833649 NA NA NA hsa-miR-664a-3p APAF1 0.0410470241619301 0.941262864923951 0.0477241419313028 0.936432778063845 mirMAP -0.112670001001515 0.0191425604229765 NA NA NA hsa-miR-708-3p APAF1 -0.031256206275331 0.971143939902443 0.0477241419313028 0.936432778063845 mirMAP -0.116215085120532 2.19939409004865e-05 NA NA NA hsa-miR-203a-3p ATM -0.148899926796224 0.936624137891012 -0.0492025146185462 0.937824476937576 MirTarget -0.10711538788314 2.54510630277939e-08 24145123;27542403 miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression drug resistance;metastasis colorectal cancer;gastric cancer hsa-miR-27a-5p ATM 0.048241955388689 0.940687050510904 -0.0492025146185462 0.937824476937576 MirTarget -0.118013745915902 0.000461560887135157 NA NA NA hsa-miR-30e-3p ATM 0.0448074101950908 0.9771684382341 -0.0492025146185462 0.937824476937576 mirMAP -0.157523794415466 0.00510124349387628 NA NA NA hsa-miR-339-5p ATM -0.0440073754970829 0.947512460035341 -0.0492025146185462 0.937824476937576 miRanda -0.155925656284305 0.000170742871820193 NA NA NA hsa-miR-590-3p ATM -0.139003976504018 0.700453857398655 -0.0492025146185462 0.937824476937576 miRanda;mirMAP -0.116855353539329 0.0127249502757536 NA NA NA hsa-miR-590-5p ATM -0.173775001452706 0.734742724035795 -0.0492025146185462 0.937824476937576 mirMAP -0.134411712770607 0.00484636149427119 NA NA NA hsa-miR-92a-3p ATM 0.0335965904378064 0.984787550750779 -0.0492025146185462 0.937824476937576 miRNAWalker2_validate -0.13971001344258 0.0112632537340507 NA NA NA hsa-miR-15b-3p BCL2 -0.107616988983747 0.885614187998235 -0.0889878660223786 0.853349418902005 mirMAP -0.160794111441143 0.0242966623676607 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-15b-5p BCL2 0.00885606323496901 0.993510047034825 -0.0889878660223786 0.853349418902005 miRNAWalker2_validate;miRTarBase -0.184030432349379 0.0279332632156109 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-16-2-3p BCL2 -0.0660098106740605 0.907925706907323 -0.0889878660223786 0.853349418902005 mirMAP -0.198780086628007 0.00813011841160033 NA NA NA hsa-miR-16-5p BCL2 0.00657489810438072 0.99567095250359 -0.0889878660223786 0.853349418902005 miRNAWalker2_validate;miRTarBase -0.272628063312585 0.00124978896318138 21336967;24447552;18449891;25435430;24598659;18931683;22966344;25623762 P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells ;worse prognosis;drug resistance;;;;poor survival;drug resistance liver cancer;lymphoma;gastric cancer;lung cancer;lymphoma;prostate cancer;pancreatic cancer;colon cancer hsa-miR-192-5p BCL2 0.209901533380535 0.862196202010764 -0.0889878660223786 0.853349418902005 miRNAWalker2_validate -0.12938914604432 0.00025104427176319 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-200a-5p BCL2 0.0561869662734349 0.964453732315041 -0.0889878660223786 0.853349418902005 mirMAP -0.195494336988318 0.000366255804733623 NA NA NA hsa-miR-200b-3p BCL2 0.00709506191350684 0.995560284306733 -0.0889878660223786 0.853349418902005 miRNAWalker2_validate;miRTarBase;TargetScan;mirMAP -0.114344876372448 0.0393261839456269 NA NA NA hsa-miR-200b-5p BCL2 0.051308474915948 0.937793950344497 -0.0889878660223786 0.853349418902005 mirMAP -0.203388603979853 0.000189900674957038 NA NA NA hsa-miR-200c-3p BCL2 0.100908924677178 0.952192851702623 -0.0889878660223786 0.853349418902005 miRNAWalker2_validate;miRTarBase;mirMAP -0.20320611228092 0.000726337324039896 NA NA NA hsa-miR-20a-3p BCL2 0.00508369553133647 0.989627610532544 -0.0889878660223786 0.853349418902005 mirMAP -0.156783828679669 0.0221974244583471 NA NA NA hsa-miR-21-5p BCL2 0.102402561735872 0.965099645724328 -0.0889878660223786 0.853349418902005 miRNAWalker2_validate;miRTarBase -0.480047476048455 4.4710057406991e-05 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-215-5p BCL2 -0.076258020737733 0.86860225072011 -0.0889878660223786 0.853349418902005 miRNAWalker2_validate -0.141357634568995 9.14425263109844e-06 NA NA NA hsa-miR-24-2-5p BCL2 -0.00924789134481596 0.988335056697837 -0.0889878660223786 0.853349418902005 miRNAWalker2_validate;miRTarBase -0.362853470345382 1.94710618153458e-06 NA NA NA hsa-miR-3065-5p BCL2 -0.318966306994077 0.311417121022653 -0.0889878660223786 0.853349418902005 mirMAP -0.167248667776853 0.000110489568744755 NA NA NA hsa-miR-32-3p BCL2 0.397110511717083 0.0372089477602239 -0.0889878660223786 0.853349418902005 mirMAP -0.159593080869614 0.0156381562883728 NA NA NA hsa-miR-338-5p BCL2 -0.0570309768373674 0.852806138741879 -0.0889878660223786 0.853349418902005 PITA -0.15384518087035 0.00172699574421937 NA NA NA hsa-miR-33b-5p BCL2 -0.117590688431901 0.751996792335634 -0.0889878660223786 0.853349418902005 miRTarBase;mirMAP -0.121788561427641 0.00899184402309845 NA NA NA hsa-miR-365a-3p BCL2 -0.0207610057665999 0.977200565399858 -0.0889878660223786 0.853349418902005 miRNAWalker2_validate;miRTarBase -0.394898362577108 1.10607300598646e-08 NA NA NA hsa-miR-429 BCL2 -0.202051344131673 0.830298580465583 -0.0889878660223786 0.853349418902005 miRNAWalker2_validate;miRTarBase;PITA;mirMAP -0.160807368066818 0.00180825818683377 23999873;26513239;26511969 MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation ;; esophageal cancer;gastric cancer;glioblastoma hsa-miR-582-5p BCL2 0.0391293212300696 0.945368171372496 -0.0889878660223786 0.853349418902005 PITA -0.134818080111642 0.00230990489507861 NA NA NA hsa-miR-590-5p BCL2 -0.173775001452706 0.734742724035795 -0.0889878660223786 0.853349418902005 miRanda -0.172313035131195 0.0324504248838897 NA NA NA hsa-miR-629-5p BCL2 0.323677537581911 0.722801100206722 -0.0889878660223786 0.853349418902005 mirMAP -0.253306211867568 7.16586879182246e-05 NA NA NA hsa-miR-7-5p BCL2 -0.0401619598321703 0.890794933327281 -0.0889878660223786 0.853349418902005 miRNAWalker2_validate;miRTarBase;mirMAP -0.1242073018915 0.00724600894737725 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-let-7a-5p BCL2L1 -0.00112050886779613 0.999528865119284 0.074885951838267 0.934460700572917 TargetScan;miRNATAP -0.195706921705561 0.0127364961268026 26915294;20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA poor survival; lung cancer;liver cancer hsa-miR-23b-3p BCL2L1 -0.0423426775157463 0.974391918147413 0.074885951838267 0.934460700572917 miRNAWalker2_validate -0.114245727673024 0.0417114260085146 NA NA NA hsa-miR-342-3p BCL2L1 0.151626922605026 0.867631856166764 0.074885951838267 0.934460700572917 PITA;miRanda;miRNATAP -0.126863966321354 0.00344426702929298 NA NA NA hsa-miR-342-5p BCL2L1 0.217497039611414 0.559186016369001 0.074885951838267 0.934460700572917 miRNATAP -0.10097662976693 0.0190123001585698 NA NA NA hsa-miR-195-3p BIRC3 -0.0817091054958705 0.737669463151026 1.08367831717726 0.12934017376737 mirMAP -0.218510545587541 0.0188439412667207 NA NA NA hsa-miR-20b-3p BIRC3 -0.239179882677375 0.542868574575866 1.08367831717726 0.12934017376737 MirTarget -0.1299107016366 0.0269745198432998 NA NA NA hsa-miR-24-1-5p BIRC3 0.0347611264612957 0.948461999421887 1.08367831717726 0.12934017376737 MirTarget -0.358268151050507 0.00120618170314208 NA NA NA hsa-miR-369-3p BIRC3 -0.205779736705628 0.5681772430766 1.08367831717726 0.12934017376737 MirTarget;miRNATAP -0.151649537106439 0.0464762854587219 NA NA NA hsa-miR-664a-3p BIRC3 0.0410470241619301 0.941262864923951 1.08367831717726 0.12934017376737 mirMAP -0.279628583632852 0.0463249234296194 NA NA NA hsa-miR-491-5p CAPN1 0.166317478383631 0.336731694935094 0.0747885796496437 0.945687829063133 miRanda -0.146719227529871 4.56515860680285e-05 NA NA NA hsa-miR-107 CAPN2 -0.143562673728446 0.855954506542642 0.0031030433543755 0.997711451157763 miRanda -0.126575945598959 0.0486589607111655 NA NA NA hsa-miR-1468-5p CAPN2 0.0764759802054626 0.786786741372286 0.0031030433543755 0.997711451157763 MirTarget -0.20208968575975 4.78335198372869e-07 NA NA NA hsa-miR-20a-3p CAPN2 0.00508369553133647 0.989627610532544 0.0031030433543755 0.997711451157763 MirTarget -0.140475332643721 0.000931394416878954 NA NA NA hsa-miR-421 CAPN2 -0.0969235906133226 0.663567108256536 0.0031030433543755 0.997711451157763 miRanda -0.109203106517093 0.0088789695877179 NA NA NA hsa-miR-125b-5p CASP10 0.230595771084394 0.84772634762119 0.319858768642188 0.605632483458243 mirMAP -0.153393011039 0.0069590481393416 NA NA NA hsa-miR-145-3p CASP10 0.0822322454945574 0.899886491849704 0.319858768642188 0.605632483458243 mirMAP -0.145980722963859 0.0215449695392116 NA NA NA hsa-miR-145-5p CASP10 0.117108956023007 0.928840184064825 0.319858768642188 0.605632483458243 mirMAP -0.142672601854187 0.0121316350864163 NA NA NA hsa-miR-186-5p CASP10 -0.0306736693084426 0.975683742421399 0.319858768642188 0.605632483458243 MirTarget;mirMAP -0.256033695965961 0.0409420486316736 NA NA NA hsa-miR-19b-3p CASP10 -0.021069663589266 0.98250214127355 0.319858768642188 0.605632483458243 MirTarget;mirMAP -0.20110867596607 0.0138500173136349 NA NA NA hsa-miR-33a-3p CASP10 0.0330412673925473 0.887935183776314 0.319858768642188 0.605632483458243 mirMAP -0.158658499843864 0.0118123887034831 NA NA NA hsa-miR-361-5p CASP10 -0.18651036457623 0.854413202155139 0.319858768642188 0.605632483458243 miRanda -0.46185739017424 0.000107312796513352 NA NA NA hsa-miR-429 CASP10 -0.202051344131673 0.830298580465583 0.319858768642188 0.605632483458243 mirMAP;miRNATAP -0.127001550793225 0.0166709250754597 NA NA NA hsa-miR-501-5p CASP10 -0.0281755984621284 0.914828113245766 0.319858768642188 0.605632483458243 mirMAP -0.162656359923242 0.0198896796897625 NA NA NA hsa-miR-532-5p CASP10 -0.108615198559221 0.928928687741948 0.319858768642188 0.605632483458243 mirMAP -0.467593826928243 3.69564958364264e-07 NA NA NA hsa-miR-589-3p CASP10 0.0761143454315903 0.725564791705791 0.319858768642188 0.605632483458243 mirMAP -0.229037416486941 0.00012648308689486 NA NA NA hsa-miR-592 CASP10 0.0483126381493639 0.903385424472886 0.319858768642188 0.605632483458243 miRNATAP -0.104832733343847 0.00729546473661119 NA NA NA hsa-miR-744-3p CASP10 -0.130158677171356 0.768294154752668 0.319858768642188 0.605632483458243 mirMAP -0.389147042180601 1.93568579672746e-12 NA NA NA hsa-miR-23a-3p CASP7 -0.000919962616247716 0.999510817457789 0.0418901940947363 0.954980341745477 MirTarget -0.158059813277252 0.0218528745159853 NA NA NA hsa-miR-361-5p CASP7 -0.18651036457623 0.854413202155139 0.0418901940947363 0.954980341745477 PITA;miRanda -0.196491640269563 0.00761577874218848 NA NA NA hsa-miR-664a-3p CASP7 0.0410470241619301 0.941262864923951 0.0418901940947363 0.954980341745477 MirTarget -0.138008785561072 0.0200924787125557 NA NA NA hsa-miR-125a-5p CFLAR 0.278586710959701 0.804894506541028 0.0758316927505431 0.913583729074697 miRanda -0.126729197885069 0.00640094446943848 NA NA NA hsa-miR-130b-3p CFLAR -0.10221778777009 0.86290232287018 0.0758316927505431 0.913583729074697 mirMAP -0.136933509317755 0.000311790699059756 NA NA NA hsa-miR-15b-5p CFLAR 0.00885606323496901 0.993510047034825 0.0758316927505431 0.913583729074697 mirMAP -0.103078703550023 0.0306697621570958 NA NA NA hsa-miR-301a-3p CFLAR -0.0963781631852707 0.822834348288596 0.0758316927505431 0.913583729074697 mirMAP -0.142408816847749 0.000173112484747624 NA NA NA hsa-miR-30b-3p CFLAR 0.192836604166322 0.342195032267304 0.0758316927505431 0.913583729074697 mirMAP -0.159754908443129 6.83731029154175e-05 NA NA NA hsa-miR-582-5p CHP2 0.0391293212300696 0.945368171372496 -0.0482124942697278 0.941867420812852 miRNATAP -0.415938249783453 0.0031281915626761 NA NA NA hsa-miR-15b-3p CSF2RB -0.107616988983747 0.885614187998235 0.0533390807668539 0.904207446932034 mirMAP -0.243883163153962 0.00378871588753218 NA NA NA hsa-miR-19b-3p CSF2RB -0.021069663589266 0.98250214127355 0.0533390807668539 0.904207446932034 MirTarget -0.249978645254246 0.00793124384654011 NA NA NA hsa-miR-30b-3p CSF2RB 0.192836604166322 0.342195032267304 0.0533390807668539 0.904207446932034 MirTarget -0.278521035137442 0.000870863627134223 NA NA NA hsa-miR-532-5p CSF2RB -0.108615198559221 0.928928687741948 0.0533390807668539 0.904207446932034 MirTarget -0.217107897448973 0.0443044265716524 NA NA NA hsa-miR-365a-3p DFFB -0.0207610057665999 0.977200565399858 -0.169337675535848 0.628106156198256 MirTarget -0.104776615460763 0.00471093454042319 NA NA NA hsa-miR-130b-3p ENDOD1 -0.10221778777009 0.86290232287018 -0.164833651946457 0.8214651732404 MirTarget -0.123811637273732 0.00768158978083829 NA NA NA hsa-miR-16-1-3p ENDOD1 -0.0202502748147722 0.95639903673924 -0.164833651946457 0.8214651732404 mirMAP -0.135967312122073 0.0145516003938159 NA NA NA hsa-miR-181a-5p ENDOD1 0.131241012385924 0.917256096248893 -0.164833651946457 0.8214651732404 MirTarget -0.187411883595055 0.00155676708701448 NA NA NA hsa-miR-181b-5p ENDOD1 0.281236821240558 0.780421351344992 -0.164833651946457 0.8214651732404 MirTarget -0.124628399892827 0.0242297145078638 NA NA NA hsa-miR-181c-5p ENDOD1 0.348865067036308 0.609372579266645 -0.164833651946457 0.8214651732404 MirTarget -0.191406533855745 0.000752702169700885 NA NA NA hsa-miR-19a-3p ENDOD1 -0.015707259355076 0.981874522841226 -0.164833651946457 0.8214651732404 mirMAP -0.123622385321676 0.00260534190818447 NA NA NA hsa-miR-19b-3p ENDOD1 -0.021069663589266 0.98250214127355 -0.164833651946457 0.8214651732404 mirMAP -0.160391298766318 0.00360487948297533 NA NA NA hsa-miR-200b-3p ENDOD1 0.00709506191350684 0.995560284306733 -0.164833651946457 0.8214651732404 TargetScan -0.126814654390186 0.000916290413422611 NA NA NA hsa-miR-26b-3p ENDOD1 -0.0453681991376325 0.934179862859451 -0.164833651946457 0.8214651732404 mirMAP -0.154240417208051 0.00986863139851759 NA NA NA hsa-miR-301a-3p ENDOD1 -0.0963781631852707 0.822834348288596 -0.164833651946457 0.8214651732404 MirTarget -0.130559457956406 0.00488088631995514 NA NA NA hsa-miR-3607-3p ENDOD1 -0.0558689743911946 0.921122504786657 -0.164833651946457 0.8214651732404 MirTarget;miRNATAP -0.111811598437114 0.0138513910980642 NA NA NA hsa-miR-3613-5p ENDOD1 -0.201024114737195 0.705927450545699 -0.164833651946457 0.8214651732404 MirTarget -0.201855032650942 4.29102693515804e-05 NA NA NA hsa-miR-362-3p ENDOD1 0.080128943742904 0.76325400634285 -0.164833651946457 0.8214651732404 miRanda -0.182370207955287 0.000231966663699426 NA NA NA hsa-miR-454-3p ENDOD1 0.136203543900226 0.745492956399051 -0.164833651946457 0.8214651732404 MirTarget -0.233643994119384 4.41462077769692e-05 NA NA NA hsa-miR-589-3p ENDOD1 0.0761143454315903 0.725564791705791 -0.164833651946457 0.8214651732404 mirMAP -0.102713708462806 0.0114984355921255 NA NA NA hsa-miR-589-5p ENDOD1 0.0235642544826264 0.975553808726613 -0.164833651946457 0.8214651732404 MirTarget -0.177647132185528 0.00560274996532207 NA NA NA hsa-miR-590-3p ENDOD1 -0.139003976504018 0.700453857398655 -0.164833651946457 0.8214651732404 miRanda -0.21562284963162 7.2235803998372e-05 NA NA NA hsa-miR-24-3p EXOG -0.00454177962947533 0.997476967221205 0.132145796859974 0.73958388311095 MirTarget -0.143003272289887 0.000748094007636054 NA NA NA hsa-miR-106a-5p FAS -0.187436837607903 0.776596826979526 0.283974648309891 0.6381131180605 miRNAWalker2_validate;miRTarBase -0.140227807754695 0.00127753821199214 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-361-5p FAS -0.18651036457623 0.854413202155139 0.283974648309891 0.6381131180605 miRanda -0.330419186265804 0.00171930259182594 NA NA NA hsa-miR-590-5p FAS -0.173775001452706 0.734742724035795 0.283974648309891 0.6381131180605 miRanda -0.19807034795777 0.00636164081342142 NA NA NA hsa-let-7e-5p FASLG 0.19604957369004 0.877087810041183 0.324937140670772 0.340156273390143 miRNATAP -0.311690734835121 0.0241590225763419 NA NA NA hsa-miR-199a-5p FASLG -0.190333205251807 0.873282228777943 0.324937140670772 0.340156273390143 miRanda -0.398497989415625 1.31601874419318e-05 NA NA NA hsa-miR-28-5p FASLG 0.112746603967525 0.895983904271527 0.324937140670772 0.340156273390143 miRanda -0.57816364875664 0.00170836414115334 NA NA NA hsa-miR-324-5p FASLG -0.00384551840892744 0.994555888813517 0.324937140670772 0.340156273390143 miRanda -0.332106354222357 0.00772738622468345 NA NA NA hsa-miR-92a-3p FASLG 0.0335965904378064 0.984787550750779 0.324937140670772 0.340156273390143 miRNATAP -0.372376902660941 0.0131300678376092 NA NA NA hsa-miR-92b-3p FASLG 0.0384207118756841 0.96614275955977 0.324937140670772 0.340156273390143 miRNATAP -0.252529060131383 0.00986337973635399 NA NA NA hsa-miR-151a-3p IKBKB -0.0117589098086164 0.993330792957847 0.0718346639873015 0.923086580140922 miRNAWalker2_validate -0.121270812981731 0.00180898875297091 NA NA NA hsa-miR-339-5p IKBKB -0.0440073754970829 0.947512460035341 0.0718346639873015 0.923086580140922 miRanda -0.112704791185609 7.01383121429463e-05 NA NA NA hsa-miR-542-3p IKBKB 0.0249538855043179 0.980961788520878 0.0718346639873015 0.923086580140922 miRanda -0.1114840138672 0.000952486304701064 NA NA NA hsa-miR-107 IKBKG -0.143562673728446 0.855954506542642 0.133159034148231 0.842381429142622 miRanda -0.111167904280604 0.0318178190037609 NA NA NA hsa-miR-125a-5p IKBKG 0.278586710959701 0.804894506541028 0.133159034148231 0.842381429142622 miRanda -0.110235437146931 0.00712043030373108 NA NA NA hsa-miR-338-5p IKBKG -0.0570309768373674 0.852806138741879 0.133159034148231 0.842381429142622 mirMAP -0.107990652303128 1.00066234929907e-05 NA NA NA hsa-miR-181c-5p IL1A 0.348865067036308 0.609372579266645 -0.436903580219244 0.398704274625543 MirTarget -0.750864040262053 0.000127388155916292 NA NA NA hsa-miR-181d-5p IL1A 0.495931172577473 0.33057044738504 -0.436903580219244 0.398704274625543 MirTarget -0.37223349359349 0.0386333962224623 NA NA NA hsa-miR-191-5p IL1A 0.116491015924133 0.916867738788489 -0.436903580219244 0.398704274625543 miRNAWalker2_validate -0.920302645458858 5.18012425368392e-06 NA NA NA hsa-miR-200a-3p IL1A 0.0892611575123006 0.935584068432955 -0.436903580219244 0.398704274625543 MirTarget -0.461162168953321 7.32399186286365e-05 NA NA NA hsa-miR-30a-5p IL1A 0.278544146596978 0.86478919764261 -0.436903580219244 0.398704274625543 MirTarget -0.52318793715064 2.12283658834032e-05 NA NA NA hsa-miR-30c-5p IL1A 0.0319636127131169 0.977297378757393 -0.436903580219244 0.398704274625543 MirTarget -0.489594165506681 0.0381755140143911 NA NA NA hsa-miR-30d-5p IL1A 0.00832663322567129 0.995690909022542 -0.436903580219244 0.398704274625543 MirTarget -0.660110352393156 0.0206593654232568 NA NA NA hsa-miR-30e-5p IL1A -0.000980722416395352 0.999509440260479 -0.436903580219244 0.398704274625543 MirTarget -0.622005267690719 0.0186645499145714 NA NA NA hsa-miR-532-5p IL1A -0.108615198559221 0.928928687741948 -0.436903580219244 0.398704274625543 MirTarget -1.49939259880363 1.12516024441561e-12 NA NA NA hsa-miR-30a-3p IL1B 0.262869410871982 0.850239043174234 -0.258549275728717 0.576655646491802 MirTarget -0.188632829792091 0.0100267069441247 NA NA NA hsa-miR-30e-3p IL1B 0.0448074101950908 0.9771684382341 -0.258549275728717 0.576655646491802 MirTarget -0.393879004731287 0.0104599199519738 NA NA NA hsa-miR-130b-5p IL1R1 0.00981184097227628 0.984687547329972 0.00475264170222633 0.994593459263769 mirMAP -0.149452338998095 0.0117092718178299 NA NA NA hsa-miR-17-3p IL1R1 0.128225890459849 0.909656106809286 0.00475264170222633 0.994593459263769 mirMAP -0.478550922210701 8.17349650316603e-08 NA NA NA hsa-miR-197-3p IL1R1 -0.0729969354891438 0.944939337616665 0.00475264170222633 0.994593459263769 miRNAWalker2_validate -0.201564995718338 0.0104802978939536 NA NA NA hsa-miR-24-3p IL1R1 -0.00454177962947533 0.997476967221205 0.00475264170222633 0.994593459263769 miRNATAP -0.159647869062635 0.0480771989300103 NA NA NA hsa-miR-30d-3p IL1R1 0.19646108479447 0.479886265992696 0.00475264170222633 0.994593459263769 mirMAP -0.223115096053911 0.0122273851081666 NA NA NA hsa-miR-335-3p IL1R1 0.0459461858975514 0.956171824626465 0.00475264170222633 0.994593459263769 mirMAP -0.223081090533626 8.58843025959345e-06 NA NA NA hsa-miR-590-3p IL1R1 -0.139003976504018 0.700453857398655 0.00475264170222633 0.994593459263769 miRanda;miRNATAP -0.147108550432802 0.0393951910177817 NA NA NA hsa-miR-106a-5p IL1RAP -0.187436837607903 0.776596826979526 0.158784156587418 0.819103901880842 MirTarget -0.218470157967721 9.0151667480019e-05 NA NA NA hsa-miR-107 IL1RAP -0.143562673728446 0.855954506542642 0.158784156587418 0.819103901880842 miRanda -0.363722797160927 0.00232718010564673 NA NA NA hsa-miR-129-5p IL1RAP -0.229611213821731 0.491303882606775 0.158784156587418 0.819103901880842 miRanda -0.107713155959696 0.0235861697439642 NA NA NA hsa-miR-130b-3p IL1RAP -0.10221778777009 0.86290232287018 0.158784156587418 0.819103901880842 MirTarget -0.183249700943366 0.0187454649455759 NA NA NA hsa-miR-186-5p IL1RAP -0.0306736693084426 0.975683742421399 0.158784156587418 0.819103901880842 mirMAP -0.718403028369971 2.51603762712787e-07 NA NA NA hsa-miR-190a-5p IL1RAP -0.0916634123384616 0.755219053015033 0.158784156587418 0.819103901880842 MirTarget -0.144190215580799 0.0449552426014772 NA NA NA hsa-miR-192-5p IL1RAP 0.209901533380535 0.862196202010764 0.158784156587418 0.819103901880842 miRNAWalker2_validate -0.252268654885249 3.56574127396124e-10 NA NA NA hsa-miR-20b-5p IL1RAP -0.246206150607389 0.757367416017597 0.158784156587418 0.819103901880842 MirTarget -0.178160427060987 1.0452389681559e-05 NA NA NA hsa-miR-215-5p IL1RAP -0.076258020737733 0.86860225072011 0.158784156587418 0.819103901880842 miRNAWalker2_validate -0.154148331658159 3.25348220932905e-05 NA NA NA hsa-miR-301a-3p IL1RAP -0.0963781631852707 0.822834348288596 0.158784156587418 0.819103901880842 MirTarget -0.237604716994952 0.00221832588789205 NA NA NA hsa-miR-335-3p IL1RAP 0.0459461858975514 0.956171824626465 0.158784156587418 0.819103901880842 mirMAP -0.158786384887794 0.014979120510779 NA NA NA hsa-miR-361-5p IL1RAP -0.18651036457623 0.854413202155139 0.158784156587418 0.819103901880842 miRanda -0.504621719246811 0.000189048746747028 NA NA NA hsa-miR-362-3p IL1RAP 0.080128943742904 0.76325400634285 0.158784156587418 0.819103901880842 miRanda -0.268765999532969 0.00124584358240993 NA NA NA hsa-miR-375 IL1RAP -0.174547017686267 0.898985810873488 0.158784156587418 0.819103901880842 miRNAWalker2_validate;miRanda -0.202285910594492 1.49808538529928e-14 NA NA NA hsa-miR-454-3p IL1RAP 0.136203543900226 0.745492956399051 0.158784156587418 0.819103901880842 MirTarget -0.212712914200949 0.0280159654989869 NA NA NA hsa-miR-7-1-3p IL1RAP 0.0894020440145336 0.872338669592458 0.158784156587418 0.819103901880842 MirTarget -0.262830853426143 0.00426933865405271 NA NA NA hsa-miR-93-5p IL1RAP -0.103495149722972 0.948829359383178 0.158784156587418 0.819103901880842 MirTarget -0.260712964664117 0.00654269721595287 NA NA NA hsa-miR-328-3p IRAK1 0.0801011068355582 0.880629616385844 -0.163037556835126 0.86718231090182 miRNAWalker2_validate -0.106324404811007 0.0206606921552805 NA NA NA hsa-miR-3065-5p IRAK2 -0.318966306994077 0.311417121022653 0.367137683485936 0.456836391446778 mirMAP -0.103253225145944 0.0314194968676248 NA NA NA hsa-miR-335-5p IRAK2 -0.0876284717522751 0.822280642381487 0.367137683485936 0.456836391446778 miRNAWalker2_validate -0.232052126462868 0.00037873058269171 NA NA NA hsa-miR-616-5p IRAK2 0.11767557301438 0.604342884687014 0.367137683485936 0.456836391446778 mirMAP -0.166160354450342 0.010912766002755 NA NA NA hsa-miR-141-3p IRAK3 0.14341518885497 0.909724976567544 0.547843820942683 0.255645961195456 mirMAP -0.124428028115031 0.0463743787233135 NA NA NA hsa-miR-148b-5p IRAK3 -0.0971255321660875 0.635443918895196 0.547843820942683 0.255645961195456 mirMAP -0.192848075625996 0.0383289566152002 NA NA NA hsa-miR-188-5p IRAK3 0.104867166668688 0.681237247873533 0.547843820942683 0.255645961195456 mirMAP -0.166621442051754 0.0329678668361846 NA NA NA hsa-miR-20a-3p IRAK3 0.00508369553133647 0.989627610532544 0.547843820942683 0.255645961195456 mirMAP -0.261465893520975 0.00147408885342381 NA NA NA hsa-miR-3200-3p IRAK3 0.00498068703757126 0.98678744989127 0.547843820942683 0.255645961195456 mirMAP -0.154032322884487 0.00255901964782929 NA NA NA hsa-miR-324-5p IRAK3 -0.00384551840892744 0.994555888813517 0.547843820942683 0.255645961195456 miRanda -0.193856000696009 0.0372260087794947 NA NA NA hsa-miR-361-5p IRAK3 -0.18651036457623 0.854413202155139 0.547843820942683 0.255645961195456 miRanda;mirMAP -0.365282147434525 0.00952444469992107 NA NA NA hsa-miR-421 IRAK3 -0.0969235906133226 0.663567108256536 0.547843820942683 0.255645961195456 miRanda;mirMAP -0.243149449692798 0.00257706348366609 NA NA NA hsa-miR-429 IRAK3 -0.202051344131673 0.830298580465583 0.547843820942683 0.255645961195456 miRanda -0.177229769626644 0.00434710987093182 NA NA NA hsa-miR-501-5p IRAK3 -0.0281755984621284 0.914828113245766 0.547843820942683 0.255645961195456 mirMAP -0.322048750119535 7.47349631798561e-05 NA NA NA hsa-miR-590-3p IRAK3 -0.139003976504018 0.700453857398655 0.547843820942683 0.255645961195456 miRanda;mirMAP -0.187032574953831 0.0496821229977895 NA NA NA hsa-miR-590-5p IRAK3 -0.173775001452706 0.734742724035795 0.547843820942683 0.255645961195456 mirMAP -0.216156703633012 0.0258318612322778 NA NA NA hsa-miR-660-5p IRAK3 -0.159091178065593 0.822022815348149 0.547843820942683 0.255645961195456 mirMAP -0.331093437975956 0.0016025474932389 NA NA NA hsa-miR-708-3p IRAK3 -0.031256206275331 0.971143939902443 0.547843820942683 0.255645961195456 mirMAP -0.165276578665181 0.0113404566494659 NA NA NA hsa-miR-9-3p IRAK3 -0.569626685515492 0.198367177172169 0.547843820942683 0.255645961195456 mirMAP -0.157203774120566 0.000355966379034606 NA NA NA hsa-miR-92a-3p IRAK3 0.0335965904378064 0.984787550750779 0.547843820942683 0.255645961195456 mirMAP -0.317244142926089 0.00448492815917761 NA NA NA hsa-miR-193a-3p IRAK4 0.124767397400679 0.792318041473515 -0.0082008906083848 0.988797407553024 miRanda -0.102433012412476 0.000571205505589283 NA NA NA hsa-miR-106b-5p MAP3K14 -0.114223082397499 0.918147136717927 0.364023916573069 0.556229892887352 MirTarget -0.147103803660124 0.0107438423053429 NA NA NA hsa-miR-17-5p MAP3K14 -0.000596233219692266 0.999589719956144 0.364023916573069 0.556229892887352 MirTarget -0.154710364889365 0.00157167780275142 NA NA NA hsa-miR-345-5p MAP3K14 0.0111886803838277 0.983411561857395 0.364023916573069 0.556229892887352 MirTarget -0.103524963377024 0.00878161781449097 NA NA NA hsa-miR-429 MAP3K14 -0.202051344131673 0.830298580465583 0.364023916573069 0.556229892887352 miRNATAP -0.116936681153463 0.000784919148104685 NA NA NA hsa-miR-93-5p MAP3K14 -0.103495149722972 0.948829359383178 0.364023916573069 0.556229892887352 MirTarget -0.2276783161594 3.94079758590909e-05 NA NA NA hsa-let-7g-5p NGF 0.0051000443410274 0.996492272103643 0.0078380399755491 0.986775645398432 MirTarget -0.75463687244667 0.00128893578106286 NA NA NA hsa-miR-429 NGF -0.202051344131673 0.830298580465583 0.0078380399755491 0.986775645398432 miRanda -0.370250673166168 6.50680322666926e-05 NA NA NA hsa-miR-146b-5p PIK3CA 0.225394330441354 0.853572932708187 -0.0161779911076492 0.978472905430507 mirMAP -0.104188309355891 0.0214970111401642 NA NA NA hsa-miR-148b-3p PIK3CA -0.0576480395180932 0.948404126433176 -0.0161779911076492 0.978472905430507 miRNAWalker2_validate -0.244141801200414 0.00147579635788138 NA NA NA hsa-miR-186-5p PIK3CA -0.0306736693084426 0.975683742421399 -0.0161779911076492 0.978472905430507 mirMAP -0.280960133798979 0.000232701716483115 NA NA NA hsa-miR-29b-1-5p PIK3CA 0.0803356397596426 0.788717272901724 -0.0161779911076492 0.978472905430507 mirMAP -0.12089066483943 0.00233700941849917 NA NA NA hsa-miR-320a PIK3CA 0.0409153600352639 0.972867457397282 -0.0161779911076492 0.978472905430507 miRanda -0.128981884483952 0.0152314868443974 NA NA NA hsa-miR-320b PIK3CA 0.0996601047414365 0.810359465912461 -0.0161779911076492 0.978472905430507 miRanda -0.121444800770151 0.00550932456475504 NA NA NA hsa-miR-335-5p PIK3CA -0.0876284717522751 0.822280642381487 -0.0161779911076492 0.978472905430507 miRNAWalker2_validate -0.124494566731403 0.000883627732385134 NA NA NA hsa-miR-338-5p PIK3CA -0.0570309768373674 0.852806138741879 -0.0161779911076492 0.978472905430507 mirMAP -0.108048495334147 0.00046563589386498 NA NA NA hsa-miR-339-5p PIK3CA -0.0440073754970829 0.947512460035341 -0.0161779911076492 0.978472905430507 miRanda -0.13798173006655 0.00178425799549926 NA NA NA hsa-miR-501-5p PIK3CA -0.0281755984621284 0.914828113245766 -0.0161779911076492 0.978472905430507 mirMAP -0.120904681333791 0.00473986403400753 NA NA NA hsa-miR-590-3p PIK3CA -0.139003976504018 0.700453857398655 -0.0161779911076492 0.978472905430507 miRanda;mirMAP -0.12312207550598 0.0133629325751335 NA NA NA hsa-miR-130a-3p PIK3CB 0.474579081939985 0.589020231280429 -0.0874582158659543 0.903470610317962 miRNATAP -0.116582529549782 0.00106378240800672 NA NA NA hsa-miR-19b-3p PIK3CB -0.021069663589266 0.98250214127355 -0.0874582158659543 0.903470610317962 miRNATAP -0.110401307134748 0.00639042894521705 NA NA NA hsa-miR-1468-5p PIK3CD 0.0764759802054626 0.786786741372286 0.21003873016187 0.718193001495828 MirTarget -0.153354934509346 0.00559561965869134 NA NA NA hsa-miR-199a-5p PIK3CD -0.190333205251807 0.873282228777943 0.21003873016187 0.718193001495828 MirTarget;PITA;miRanda;miRNATAP -0.160352223725155 0.000860262558034989 NA NA NA hsa-miR-30d-5p PIK3CD 0.00832663322567129 0.995690909022542 0.21003873016187 0.718193001495828 MirTarget;miRNATAP -0.269704587228763 0.00722775970426478 NA NA NA hsa-miR-324-5p PIK3CD -0.00384551840892744 0.994555888813517 0.21003873016187 0.718193001495828 miRanda -0.167057802158617 0.010407823026026 NA NA NA hsa-miR-3913-5p PIK3CD -0.0226857734721915 0.929747532799218 0.21003873016187 0.718193001495828 mirMAP -0.258109601835399 0.00117084989668902 NA NA NA hsa-miR-335-3p PIK3CG 0.0459461858975514 0.956171824626465 0.0897276739578496 0.720712418685465 mirMAP -0.289128547018831 6.98940085423769e-06 NA NA NA hsa-miR-502-5p PIK3CG -0.399402466528722 0.0371413760055171 0.0897276739578496 0.720712418685465 miRNATAP -0.170404506210511 0.0284752528790852 26163264 Phosphoinositide 3-kinase catalytic subunit gamma PIK3CG was identified as a direct downstream target of miR-502 in HCC cells; Notably overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells liver cancer hsa-miR-1301-3p PIK3R1 0.215916819876655 0.634872511522417 -0.148543685192655 0.832676990930827 MirTarget -0.135408648859421 0.0487168326048714 NA NA NA hsa-miR-16-2-3p PIK3R1 -0.0660098106740605 0.907925706907323 -0.148543685192655 0.832676990930827 MirTarget -0.220421111740374 0.0054973163518176 NA NA NA hsa-miR-16-5p PIK3R1 0.00657489810438072 0.99567095250359 -0.148543685192655 0.832676990930827 MirTarget -0.232718839097215 0.0094069232214411 NA NA NA hsa-miR-17-5p PIK3R1 -0.000596233219692266 0.999589719956144 -0.148543685192655 0.832676990930827 MirTarget;TargetScan;miRNATAP -0.263550021803503 0.000561403048031031 NA NA NA hsa-miR-182-5p PIK3R1 -0.123533474001965 0.944870865201631 -0.148543685192655 0.832676990930827 miRNATAP -0.123631904426682 0.0246928295730376 NA NA NA hsa-miR-200c-3p PIK3R1 0.100908924677178 0.952192851702623 -0.148543685192655 0.832676990930827 mirMAP -0.209884750055895 0.000971059963262446 NA NA NA hsa-miR-20a-5p PIK3R1 0.0114792099504992 0.991781949567624 -0.148543685192655 0.832676990930827 MirTarget;miRNATAP -0.16773716444277 0.0232604396745217 NA NA NA hsa-miR-21-5p PIK3R1 0.102402561735872 0.965099645724328 -0.148543685192655 0.832676990930827 miRNAWalker2_validate;MirTarget;miRNATAP -0.296975751298422 0.0179761051209979 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 -0.0119558238852235 0.98487566102761 -0.148543685192655 0.832676990930827 mirMAP -0.166300707017564 0.0322007854872272 NA NA NA hsa-miR-29a-3p PIK3R1 0.144361548745149 0.928458118904984 -0.148543685192655 0.832676990930827 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.158482628577245 0.03846338914674 NA NA NA hsa-miR-29b-3p PIK3R1 0.142303641653058 0.900102271992252 -0.148543685192655 0.832676990930827 MirTarget;miRNATAP -0.229458801110313 0.00247922380727846 NA NA NA hsa-miR-3065-5p PIK3R1 -0.318966306994077 0.311417121022653 -0.148543685192655 0.832676990930827 MirTarget;mirMAP;miRNATAP -0.136442762182432 0.00300321263691178 NA NA NA hsa-miR-32-3p PIK3R1 0.397110511717083 0.0372089477602239 -0.148543685192655 0.832676990930827 mirMAP -0.159533357320395 0.0224038643587963 NA NA NA hsa-miR-320b PIK3R1 0.0996601047414365 0.810359465912461 -0.148543685192655 0.832676990930827 miRNATAP -0.176164651324681 0.0166344864485862 NA NA NA hsa-miR-320c PIK3R1 0.167820674105902 0.355392574548112 -0.148543685192655 0.832676990930827 miRNATAP -0.237528056213487 0.00153215444016214 NA NA NA hsa-miR-330-3p PIK3R1 -0.011452549052418 0.970394129262563 -0.148543685192655 0.832676990930827 MirTarget;PITA;miRNATAP -0.222421511130143 0.000560333266659095 NA NA NA hsa-miR-335-3p PIK3R1 0.0459461858975514 0.956171824626465 -0.148543685192655 0.832676990930827 mirMAP -0.187424798668302 0.00154671007013318 NA NA NA hsa-miR-338-5p PIK3R1 -0.0570309768373674 0.852806138741879 -0.148543685192655 0.832676990930827 PITA -0.149038254580324 0.00415133065382571 NA NA NA hsa-miR-455-3p PIK3R1 0.137296059937864 0.889752053946795 -0.148543685192655 0.832676990930827 MirTarget;PITA;miRNATAP -0.154714937051356 0.0121083771583488 NA NA NA hsa-miR-582-5p PIK3R1 0.0391293212300696 0.945368171372496 -0.148543685192655 0.832676990930827 mirMAP -0.168928206892885 0.000293205730117536 NA NA NA hsa-miR-584-5p PIK3R1 0.190228408166915 0.803568824349321 -0.148543685192655 0.832676990930827 mirMAP -0.264485629334745 3.0909574049315e-09 NA NA NA hsa-miR-590-3p PIK3R1 -0.139003976504018 0.700453857398655 -0.148543685192655 0.832676990930827 miRanda;mirMAP -0.189026585514548 0.0237715511845409 NA NA NA hsa-miR-590-5p PIK3R1 -0.173775001452706 0.734742724035795 -0.148543685192655 0.832676990930827 MirTarget;PITA;miRanda;miRNATAP -0.297003967343676 0.000452335914243657 NA NA NA hsa-miR-629-3p PIK3R1 0.264171606611622 0.479075142876712 -0.148543685192655 0.832676990930827 MirTarget -0.21216292379107 0.00105654186835094 NA NA NA hsa-miR-1271-5p PIK3R3 0.113785697335253 0.664637583993702 0.00978105554023401 0.989576204398345 mirMAP -0.151933011438603 0.00299533512999816 NA NA NA hsa-miR-18a-3p PIK3R3 0.047371679150885 0.849100837614421 0.00978105554023401 0.989576204398345 miRNAWalker2_validate -0.172437749406846 8.76134189601592e-05 NA NA NA hsa-miR-19b-3p PIK3R3 -0.021069663589266 0.98250214127355 0.00978105554023401 0.989576204398345 MirTarget;miRNATAP -0.133034812969295 0.0429014365024994 NA NA NA hsa-miR-222-5p PIK3R3 0.330318684461812 0.489738152851363 0.00978105554023401 0.989576204398345 mirMAP -0.169591357898129 3.80520658072856e-05 NA NA NA hsa-miR-26b-5p PIK3R3 -0.00510702880331593 0.996607798179271 0.00978105554023401 0.989576204398345 miRNATAP -0.161901214865155 0.0389212618860389 NA NA NA hsa-miR-29b-1-5p PIK3R3 0.0803356397596426 0.788717272901724 0.00978105554023401 0.989576204398345 mirMAP -0.214703534793861 3.15537480066889e-05 NA NA NA hsa-miR-32-5p PIK3R3 0.0628705653766719 0.926491719877421 0.00978105554023401 0.989576204398345 MirTarget;miRNATAP -0.160755914279694 0.019115600005757 NA NA NA hsa-miR-330-3p PIK3R3 -0.011452549052418 0.970394129262563 0.00978105554023401 0.989576204398345 MirTarget -0.191183653307302 0.000135580399986553 NA NA NA hsa-miR-330-5p PIK3R3 0.00970192961000116 0.988324849760483 0.00978105554023401 0.989576204398345 miRanda -0.158989578902319 0.00262587059425892 NA NA NA hsa-miR-335-3p PIK3R3 0.0459461858975514 0.956171824626465 0.00978105554023401 0.989576204398345 mirMAP -0.103464572034936 0.025428137853466 NA NA NA hsa-miR-365a-3p PIK3R3 -0.0207610057665999 0.977200565399858 0.00978105554023401 0.989576204398345 MirTarget -0.330277583325266 6.38384266733533e-09 NA NA NA hsa-miR-511-5p PIK3R3 0.16436177858313 0.680167129063066 0.00978105554023401 0.989576204398345 MirTarget -0.179185145111208 6.38466351145281e-06 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-590-3p PIK3R3 -0.139003976504018 0.700453857398655 0.00978105554023401 0.989576204398345 PITA;mirMAP;miRNATAP -0.135597711481687 0.0374254282287608 NA NA NA hsa-miR-590-5p PIK3R3 -0.173775001452706 0.734742724035795 0.00978105554023401 0.989576204398345 miRanda -0.195493025557274 0.00311783468590026 NA NA NA hsa-miR-92a-3p PIK3R3 0.0335965904378064 0.984787550750779 0.00978105554023401 0.989576204398345 MirTarget;miRNATAP -0.181892014402978 0.0174346731946844 NA NA NA hsa-miR-125a-3p PIK3R5 0.119245934253913 0.752909794176976 0.0650949060705845 0.852818680663509 miRanda -0.143772140191083 0.00747323319002246 NA NA NA hsa-miR-125a-5p PIK3R5 0.278586710959701 0.804894506541028 0.0650949060705845 0.852818680663509 MirTarget;miRanda -0.250957855170204 0.00223286885929377 NA NA NA hsa-miR-182-5p PIK3R5 -0.123533474001965 0.944870865201631 0.0650949060705845 0.852818680663509 MirTarget -0.25329203027594 9.2894340160784e-07 NA NA NA hsa-let-7g-5p PPP3CA 0.0051000443410274 0.996492272103643 -0.0412021865513008 0.954828087123066 miRNATAP -0.161347150543761 0.00879795113322894 NA NA NA hsa-miR-361-3p PPP3CA 0.0304329120700579 0.974956209185769 -0.0412021865513008 0.954828087123066 MirTarget;PITA;miRNATAP -0.1244680543674 0.0103177804265776 NA NA NA hsa-let-7a-3p PRKACB -0.0587284699785764 0.934080921687498 -0.0375823222215894 0.950040491488837 MirTarget;mirMAP;miRNATAP -0.212227756129949 0.00484060334729975 NA NA NA hsa-let-7f-1-3p PRKACB 0.172471926572875 0.566835368063954 -0.0375823222215894 0.950040491488837 MirTarget;mirMAP -0.153633672665785 0.0188406734868941 NA NA NA hsa-miR-141-3p PRKACB 0.14341518885497 0.909724976567544 -0.0375823222215894 0.950040491488837 MirTarget;TargetScan;miRNATAP -0.179713976485568 5.50509722074074e-06 NA NA NA hsa-miR-16-2-3p PRKACB -0.0660098106740605 0.907925706907323 -0.0375823222215894 0.950040491488837 mirMAP -0.256987391063205 7.64721558586313e-06 NA NA NA hsa-miR-17-5p PRKACB -0.000596233219692266 0.999589719956144 -0.0375823222215894 0.950040491488837 TargetScan -0.147030961972885 0.00870649595844882 NA NA NA hsa-miR-182-5p PRKACB -0.123533474001965 0.944870865201631 -0.0375823222215894 0.950040491488837 MirTarget;miRNATAP -0.137741652786639 0.000572629355125557 NA NA NA hsa-miR-183-5p PRKACB -0.283313900214583 0.860532410379705 -0.0375823222215894 0.950040491488837 MirTarget -0.125680903296988 0.000602029705127091 NA NA NA hsa-miR-18a-5p PRKACB -0.192028568618394 0.739225908511128 -0.0375823222215894 0.950040491488837 miRNATAP -0.147626596716624 0.00172397395444837 NA NA NA hsa-miR-193a-3p PRKACB 0.124767397400679 0.792318041473515 -0.0375823222215894 0.950040491488837 miRanda -0.257394862253127 1.9252355211219e-05 NA NA NA hsa-miR-19a-3p PRKACB -0.015707259355076 0.981874522841226 -0.0375823222215894 0.950040491488837 MirTarget;miRNATAP -0.131490327577289 0.0040920531186784 NA NA NA hsa-miR-19b-3p PRKACB -0.021069663589266 0.98250214127355 -0.0375823222215894 0.950040491488837 miRNAWalker2_validate;MirTarget;miRNATAP -0.191193316637283 0.00183404785527112 NA NA NA hsa-miR-200a-3p PRKACB 0.0892611575123006 0.935584068432955 -0.0375823222215894 0.950040491488837 MirTarget;miRNATAP -0.104144124001908 0.00576356163422443 NA NA NA hsa-miR-200c-3p PRKACB 0.100908924677178 0.952192851702623 -0.0375823222215894 0.950040491488837 MirTarget;miRNATAP -0.145130591541329 0.00181365494045828 NA NA NA hsa-miR-2110 PRKACB -0.0159794230470369 0.927486930242688 -0.0375823222215894 0.950040491488837 MirTarget -0.110796601580735 0.0478171002562626 NA NA NA hsa-miR-3065-5p PRKACB -0.318966306994077 0.311417121022653 -0.0375823222215894 0.950040491488837 MirTarget -0.128827162641901 0.000116356569225078 NA NA NA hsa-miR-30d-3p PRKACB 0.19646108479447 0.479886265992696 -0.0375823222215894 0.950040491488837 mirMAP -0.149931488326972 0.0496499969555609 NA NA NA hsa-miR-362-3p PRKACB 0.080128943742904 0.76325400634285 -0.0375823222215894 0.950040491488837 PITA;miRanda;miRNATAP -0.132462710993008 0.0171492521812846 NA NA NA hsa-miR-3653-3p PRKACB -0.157544484957551 0.565559216278092 -0.0375823222215894 0.950040491488837 MirTarget -0.101834528600714 0.0351697054212881 NA NA NA hsa-miR-429 PRKACB -0.202051344131673 0.830298580465583 -0.0375823222215894 0.950040491488837 MirTarget;PITA;miRanda;miRNATAP -0.108770954611392 0.00641118010678973 NA NA NA hsa-miR-590-3p PRKACB -0.139003976504018 0.700453857398655 -0.0375823222215894 0.950040491488837 MirTarget;PITA;miRanda;miRNATAP -0.150489017415495 0.0136835439007164 NA NA NA hsa-miR-590-5p PRKACB -0.173775001452706 0.734742724035795 -0.0375823222215894 0.950040491488837 miRanda -0.159509934061525 0.0102765865766552 NA NA NA hsa-miR-93-5p PRKACB -0.103495149722972 0.948829359383178 -0.0375823222215894 0.950040491488837 miRNAWalker2_validate -0.1828758599464 0.00409856289818273 NA NA NA hsa-miR-96-5p PRKACB -0.175083856582125 0.772848419789491 -0.0375823222215894 0.950040491488837 miRNATAP -0.17033105097326 3.99524226143001e-05 NA NA NA hsa-miR-186-5p PRKAR1A -0.0306736693084426 0.975683742421399 0.131714622791955 0.894175780063422 mirMAP -0.180144708459278 0.000892993033458124 NA NA NA hsa-miR-25-3p PRKAR1A -0.0772543757825961 0.964382394841313 0.131714622791955 0.894175780063422 miRNAWalker2_validate -0.137457165995076 0.00373320016478192 NA NA NA hsa-miR-30e-5p PRKAR1A -0.000980722416395352 0.999509440260479 0.131714622791955 0.894175780063422 mirMAP -0.195080535639843 6.48511031213636e-05 NA NA NA hsa-miR-590-3p PRKAR1A -0.139003976504018 0.700453857398655 0.131714622791955 0.894175780063422 miRanda;mirMAP -0.117659255376238 0.000811435622796728 NA NA NA hsa-miR-590-5p PRKAR1A -0.173775001452706 0.734742724035795 0.131714622791955 0.894175780063422 miRanda -0.10914100263527 0.00232969513055624 NA NA NA hsa-let-7a-3p PRKAR2A -0.0587284699785764 0.934080921687498 -0.0233697434712177 0.953578680106019 mirMAP -0.301009578826657 0.00647099970354146 NA NA NA hsa-let-7f-1-3p PRKAR2A 0.172471926572875 0.566835368063954 -0.0233697434712177 0.953578680106019 mirMAP -0.216904265787296 0.023842927545171 NA NA NA hsa-miR-125a-5p PRKAR2A 0.278586710959701 0.804894506541028 -0.0233697434712177 0.953578680106019 miRanda -0.269844648912326 0.00350273799952414 NA NA NA hsa-miR-155-5p PRKAR2A 0.150755193213955 0.894622203994624 -0.0233697434712177 0.953578680106019 miRNAWalker2_validate -0.21708406345224 0.000566306153716087 NA NA NA hsa-miR-26a-5p PRKAR2A 0.110457386875835 0.937612316892532 -0.0233697434712177 0.953578680106019 mirMAP -0.334762860834375 0.00501415610057783 NA NA NA hsa-miR-26b-5p PRKAR2A -0.00510702880331593 0.996607798179271 -0.0233697434712177 0.953578680106019 mirMAP -0.286017162331329 0.00788651739787191 NA NA NA hsa-miR-28-5p PRKAR2A 0.112746603967525 0.895983904271527 -0.0233697434712177 0.953578680106019 miRanda -0.282863710025104 0.0292450508726876 NA NA NA hsa-miR-29a-5p PRKAR2A 0.18117722740642 0.583528211572362 -0.0233697434712177 0.953578680106019 mirMAP -0.315640015483038 0.000372346869393992 NA NA NA hsa-miR-320a PRKAR2A 0.0409153600352639 0.972867457397282 -0.0233697434712177 0.953578680106019 mirMAP -0.268019149243362 0.00499308515469227 NA NA NA hsa-miR-320b PRKAR2A 0.0996601047414365 0.810359465912461 -0.0233697434712177 0.953578680106019 mirMAP -0.160674727798191 0.0418289894929402 NA NA NA hsa-miR-335-5p PRKAR2A -0.0876284717522751 0.822280642381487 -0.0233697434712177 0.953578680106019 mirMAP -0.141560345781286 0.0366018295244779 NA NA NA hsa-miR-342-5p PRKAR2A 0.217497039611414 0.559186016369001 -0.0233697434712177 0.953578680106019 miRNATAP -0.269573945336104 0.000654404755458937 NA NA NA hsa-miR-3607-3p PRKAR2A -0.0558689743911946 0.921122504786657 -0.0233697434712177 0.953578680106019 mirMAP -0.244787916293228 0.000939419376053357 NA NA NA hsa-miR-3913-5p PRKAR2A -0.0226857734721915 0.929747532799218 -0.0233697434712177 0.953578680106019 mirMAP -0.246421830440637 0.0213785759516597 NA NA NA hsa-miR-708-3p PRKAR2A -0.031256206275331 0.971143939902443 -0.0233697434712177 0.953578680106019 mirMAP -0.152913264224168 0.0128401604293749 NA NA NA hsa-let-7a-3p PRKAR2B -0.0587284699785764 0.934080921687498 -0.0245622943342667 0.949319497223225 mirMAP -0.490436382372777 0.000131692115153379 NA NA NA hsa-let-7f-1-3p PRKAR2B 0.172471926572875 0.566835368063954 -0.0245622943342667 0.949319497223225 mirMAP -0.590656604378212 7.69012984955533e-08 NA NA NA hsa-miR-200c-3p PRKAR2B 0.100908924677178 0.952192851702623 -0.0245622943342667 0.949319497223225 miRNATAP -0.232410940316261 0.00356398855766406 NA NA NA hsa-miR-32-5p PRKAR2B 0.0628705653766719 0.926491719877421 -0.0245622943342667 0.949319497223225 miRNATAP -0.359735337701038 0.00104357271928938 NA NA NA hsa-miR-335-3p PRKAR2B 0.0459461858975514 0.956171824626465 -0.0245622943342667 0.949319497223225 mirMAP -0.188812955591594 0.0110198275001046 NA NA NA hsa-miR-429 PRKAR2B -0.202051344131673 0.830298580465583 -0.0245622943342667 0.949319497223225 PITA;miRanda;miRNATAP -0.136030845210326 0.0470940607906142 NA NA NA hsa-miR-590-3p PRKAR2B -0.139003976504018 0.700453857398655 -0.0245622943342667 0.949319497223225 miRNAWalker2_validate;miRanda -0.336156932957071 0.00124725671489497 NA NA NA hsa-miR-92a-3p PRKAR2B 0.0335965904378064 0.984787550750779 -0.0245622943342667 0.949319497223225 miRNATAP -0.399693388608365 0.00109215156585527 NA NA NA hsa-miR-944 PRKAR2B -0.316321233715507 0.703644676773439 -0.0245622943342667 0.949319497223225 mirMAP -0.153211582863098 2.7267140771681e-07 NA NA NA hsa-miR-130a-5p PRKX 0.384075718738944 0.082831396840774 -0.144452246989882 0.853588908508336 mirMAP -0.187730727746443 0.00038419514315305 NA NA NA hsa-miR-148b-3p PRKX -0.0576480395180932 0.948404126433176 -0.144452246989882 0.853588908508336 MirTarget -0.306982570800927 0.00606517379097925 NA NA NA hsa-miR-181b-5p PRKX 0.281236821240558 0.780421351344992 -0.144452246989882 0.853588908508336 mirMAP -0.171922484715549 0.0185944166277157 NA NA NA hsa-miR-29b-3p PRKX 0.142303641653058 0.900102271992252 -0.144452246989882 0.853588908508336 mirMAP -0.164536960121623 0.0124366136750478 NA NA NA hsa-miR-335-3p PRKX 0.0459461858975514 0.956171824626465 -0.144452246989882 0.853588908508336 mirMAP -0.162862473837577 0.00148982890472507 NA NA NA hsa-miR-361-5p TNF -0.18651036457623 0.854413202155139 0.392314389091534 0.230133702403534 miRanda -0.699393715835311 3.55980064084335e-05 NA NA NA hsa-miR-429 TNF -0.202051344131673 0.830298580465583 0.392314389091534 0.230133702403534 miRNATAP -0.166672367413636 0.0271661300621378 NA NA NA hsa-miR-654-3p TNF -0.21962598164265 0.691692134557376 0.392314389091534 0.230133702403534 miRNATAP -0.184952039903252 0.006307888857058 NA NA NA hsa-miR-28-5p TNFRSF10B 0.112746603967525 0.895983904271527 -0.0895232774824528 0.913402895937326 miRanda -0.176105256176701 0.0281698781078749 NA NA NA hsa-miR-340-5p TNFRSF10B -0.0974274402696707 0.851532876458098 -0.0895232774824528 0.913402895937326 miRNAWalker2_validate -0.149759402379779 0.00368309518497458 NA NA NA hsa-miR-26a-5p TNFRSF10D 0.110457386875835 0.937612316892532 -0.151202319201273 0.733256997836619 mirMAP -0.443727421653665 0.000175681471900891 NA NA NA hsa-miR-590-3p TNFRSF10D -0.139003976504018 0.700453857398655 -0.151202319201273 0.733256997836619 miRanda -0.213832330292469 0.0165761405332802 NA NA NA hsa-miR-7-1-3p TNFRSF10D 0.0894020440145336 0.872338669592458 -0.151202319201273 0.733256997836619 mirMAP -0.202460494552346 0.0238821195932147 NA NA NA hsa-miR-766-3p TNFRSF1A 0.0931663545224866 0.831563979454727 0.019542155140277 0.983180473015492 MirTarget -0.100128221820332 0.00599976091689645 NA NA NA hsa-miR-129-5p TNFSF10 -0.229611213821731 0.491303882606775 0.137721281186336 0.898064113999021 miRanda -0.207618069660698 9.59656903576055e-05 NA NA NA hsa-miR-217 TNFSF10 0.0105356435591801 0.980745425485859 0.137721281186336 0.898064113999021 miRanda -0.202017009365184 5.47278192731572e-05 NA NA NA hsa-miR-361-5p TNFSF10 -0.18651036457623 0.854413202155139 0.137721281186336 0.898064113999021 miRanda -0.417422213365056 0.00645858491593377 NA NA NA hsa-miR-324-3p TRADD -0.101952390736283 0.848252985770446 0.00198808073225987 0.997514268313622 miRNATAP -0.163418626847223 0.000228267741497048 NA NA NA hsa-miR-140-3p TRAF2 -0.0871602013936155 0.943067353850607 0.188462730641254 0.788692443051931 MirTarget -0.118674027002529 0.0489723600787535 NA NA NA hsa-miR-17-5p XIAP -0.000596233219692266 0.999589719956144 0.0141317398094971 0.985598037387198 miRNAWalker2_validate;TargetScan -0.115272263388315 0.000232899306031091 NA NA NA hsa-miR-19b-1-5p XIAP 0.144949250637873 0.755492973890875 0.0141317398094971 0.985598037387198 MirTarget -0.130591301091723 0.000335776643741966 NA NA NA hsa-miR-19b-3p XIAP -0.021069663589266 0.98250214127355 0.0141317398094971 0.985598037387198 mirMAP -0.100699249525642 0.00352329780167423 NA NA NA hsa-miR-25-3p XIAP -0.0772543757825961 0.964382394841313 0.0141317398094971 0.985598037387198 mirMAP -0.166772933993496 0.000279588647819815 NA NA NA hsa-miR-32-3p XIAP 0.397110511717083 0.0372089477602239 0.0141317398094971 0.985598037387198 mirMAP -0.100227774344178 0.000439730838218322 NA NA NA hsa-miR-484 XIAP -0.100225592250568 0.895507183644022 0.0141317398094971 0.985598037387198 mirMAP -0.105802985633609 0.00311442744504824 NA NA NA hsa-miR-92a-3p XIAP 0.0335965904378064 0.984787550750779 0.0141317398094971 0.985598037387198 mirMAP -0.136415865455041 0.000676507864354257 NA NA NA