miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p AKT2 -1.37014061604018 3.11451492971224e-14 0.158500088541505 0.113504798741429 TargetScan -0.119930037553526 1.13227688326527e-06 NA NA NA hsa-miR-29a-3p AKT2 0.101650412194573 0.573201097011668 0.158500088541505 0.113504798741429 MirTarget -0.104368014677354 4.26511869332683e-05 24076586 Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis acute myeloid leukemia hsa-miR-106b-5p AKT3 1.47447672652218 1.32004094930462e-13 -1.44031241124732 2.576504600149e-09 miRNATAP -0.158920731526324 0.00425859940487133 NA NA NA hsa-miR-107 AKT3 0.658676029898313 5.11480446318819e-07 -1.44031241124732 2.576504600149e-09 PITA;miRanda -0.256548300142307 0.00309702957622585 NA NA NA hsa-miR-146b-5p AKT3 1.0922867893808 5.63754607494775e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate -0.14508398550335 0.00188822517544197 NA NA NA hsa-miR-15a-5p AKT3 1.62575353599172 1.55312121019827e-19 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.412918804091755 4.08840965026726e-12 NA NA NA hsa-miR-16-5p AKT3 0.749619098384047 4.11649450706988e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.269698520974258 9.94440318719177e-05 NA NA NA hsa-miR-17-5p AKT3 2.07078488653279 2.77403038572568e-19 -1.44031241124732 2.576504600149e-09 TargetScan;miRNATAP -0.217476886844258 3.56953935954486e-06 NA NA NA hsa-miR-181a-5p AKT3 -0.375429731222937 0.0562142867129802 -1.44031241124732 2.576504600149e-09 miRNATAP -0.22550600060725 9.19470016250579e-05 NA NA NA hsa-miR-181b-5p AKT3 0.668793269169928 0.000239998092406404 -1.44031241124732 2.576504600149e-09 miRNATAP -0.367498754199467 2.09865276667175e-09 NA NA NA hsa-miR-20a-5p AKT3 2.64649625616975 5.1469418982085e-27 -1.44031241124732 2.576504600149e-09 miRNATAP -0.24430728120197 1.27608550819212e-08 NA NA NA hsa-miR-22-3p AKT3 1.42501909916631 1.72295005910055e-25 -1.44031241124732 2.576504600149e-09 miRNATAP -0.259390140878921 0.0010937362716222 NA NA NA hsa-miR-29b-2-5p AKT3 0.345881055247341 0.194842633194187 -1.44031241124732 2.576504600149e-09 mirMAP -0.181342398720756 1.80199534450665e-05 NA NA NA hsa-miR-29b-3p AKT3 3.10527711861309 3.01242507282711e-32 -1.44031241124732 2.576504600149e-09 miRNATAP -0.267243460090773 1.17871192498365e-11 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 0.653308707552535 0.0999497219778851 -1.44031241124732 2.576504600149e-09 mirMAP -0.18242132898273 2.34990243224026e-09 NA NA NA hsa-miR-362-5p AKT3 0.658947634569393 0.0243306847205756 -1.44031241124732 2.576504600149e-09 PITA;TargetScan;miRNATAP -0.229571357984291 4.43564207755877e-09 NA NA NA hsa-miR-542-3p AKT3 1.62226640768239 2.6427102465476e-10 -1.44031241124732 2.576504600149e-09 miRanda -0.186790699816246 1.44501888663791e-05 NA NA NA hsa-miR-93-5p AKT3 1.50844106515467 1.83836866996875e-12 -1.44031241124732 2.576504600149e-09 miRNATAP -0.251105283811718 1.01733106411986e-06 NA NA NA hsa-miR-335-3p ANGPT1 1.51116383169018 6.88553098788624e-13 -2.86129771115012 8.84824325579863e-17 mirMAP -0.334486749250077 1.02763639483715e-05 NA NA NA hsa-miR-429 ANGPT1 2.3794516574089 1.72813419703734e-13 -2.86129771115012 8.84824325579863e-17 miRanda -0.251490713644337 2.2923141795107e-06 NA NA NA hsa-miR-590-3p ANGPT1 0.83851360565783 0.00129224433453587 -2.86129771115012 8.84824325579863e-17 PITA;miRanda;mirMAP -0.399492004581028 8.37484766920582e-08 NA NA NA hsa-miR-125a-5p ANGPT2 -1.04824536696301 3.97386082850476e-07 -0.355224254667991 0.234922406432455 miRanda -0.22928507808614 0.000503419130204071 NA NA NA hsa-miR-135b-5p ANGPT2 3.25019233805845 1.95560099639034e-15 -0.355224254667991 0.234922406432455 MirTarget -0.207372824603929 2.48196533716168e-09 NA NA NA hsa-miR-142-5p ANGPT2 1.29672439149353 4.0768822158894e-06 -0.355224254667991 0.234922406432455 MirTarget -0.151236689175521 0.00402617752870704 NA NA NA hsa-miR-186-5p ANGPT2 0.852175445703945 6.88885738584309e-10 -0.355224254667991 0.234922406432455 MirTarget;mirMAP -0.39229247734846 7.15903079089934e-05 NA NA NA hsa-miR-34c-5p ANGPT2 -1.00125440032112 0.0724432896090357 -0.355224254667991 0.234922406432455 miRanda -0.164341248696704 1.1475669197363e-10 NA NA NA hsa-miR-374a-5p ANGPT2 -0.197027254874826 0.298080902192861 -0.355224254667991 0.234922406432455 mirMAP -0.25710085678133 0.00170679143063428 NA NA NA hsa-miR-374b-5p ANGPT2 0.474691035780475 0.0109217471394203 -0.355224254667991 0.234922406432455 mirMAP -0.218997533012079 0.00511463662677723 NA NA NA hsa-miR-429 ANGPT2 2.3794516574089 1.72813419703734e-13 -0.355224254667991 0.234922406432455 miRanda -0.222922419850056 5.7113477777819e-07 NA NA NA hsa-miR-664a-3p ANGPT2 0.443077463053857 0.0214248925850984 -0.355224254667991 0.234922406432455 mirMAP -0.386891912279747 4.93812758809701e-08 NA NA NA hsa-let-7a-3p ATF2 0.167285443861993 0.431834813181487 0.0108252986583377 0.936889208236278 MirTarget;mirMAP;miRNATAP -0.128835404212926 9.65527356851969e-05 NA NA NA hsa-miR-140-3p ATF2 -1.11373309124537 8.35257079443689e-14 0.0108252986583377 0.936889208236278 MirTarget;PITA;miRNATAP -0.155363141988392 0.000162576373114767 NA NA NA hsa-miR-15a-5p ATF2 1.62575353599172 1.55312121019827e-19 0.0108252986583377 0.936889208236278 miRNAWalker2_validate -0.194111389282878 5.03172071069784e-09 NA NA NA hsa-miR-181a-5p ATF2 -0.375429731222937 0.0562142867129802 0.0108252986583377 0.936889208236278 mirMAP;miRNATAP -0.15087869419291 2.07790173520328e-06 NA NA NA hsa-miR-222-3p ATF2 0.0327210697409583 0.881937768109611 0.0108252986583377 0.936889208236278 MirTarget -0.131684536657296 3.51039503254779e-06 NA NA NA hsa-miR-26b-5p ATF2 0.72362441215247 4.7794659748036e-05 0.0108252986583377 0.936889208236278 MirTarget;miRNATAP -0.122447422445475 0.000494610369299413 21901137 Coordinated regulation of ATF2 by miR 26b in γ irradiated lung cancer cells; Concurrent analysis of time-series mRNA and microRNA profiles uncovered that expression of miR-26b was down regulated and its target activating transcription factor 2 ATF2 mRNA was up regulated in γ-irradiated H1299 cells; IR in miR-26b overexpressed H1299 cells could not induce expression of ATF2; From these results we concluded that IR-induced up-regulation of ATF2 was coordinately enhanced by suppression of miR-26b in lung cancer cells which may enhance the effect of IR in the MAPK signaling pathway lung cancer hsa-miR-30b-5p ATF2 0.358144314839612 0.138026229059594 0.0108252986583377 0.936889208236278 mirMAP -0.178384785370869 2.48045163615783e-12 NA NA NA hsa-miR-30c-5p ATF2 -0.327319105755825 0.123595832152687 0.0108252986583377 0.936889208236278 mirMAP -0.260700722002115 5.109462900737e-20 NA NA NA hsa-miR-374a-5p ATF2 -0.197027254874826 0.298080902192861 0.0108252986583377 0.936889208236278 mirMAP -0.161311101413889 1.41360976287521e-05 NA NA NA hsa-miR-15a-5p BCL2 1.62575353599172 1.55312121019827e-19 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.187458177651156 0.00400964703367561 26915294;25594541;18931683;25623762;22335947 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 poor survival;;;drug resistance; lung cancer;breast cancer;prostate cancer;colon cancer;breast cancer hsa-miR-21-5p BCL2 4.38165933891779 1.52536633902505e-92 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.204010104736014 8.81514964878011e-06 22964582;21468550;25994220;25381586;26555418;23359184;21376256 Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance lung cancer;bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;pancreatic cancer hsa-miR-224-5p BCL2 1.9183903633152 3.22216766330296e-06 -0.487496069869486 0.0642113742980754 mirMAP -0.138108415745186 1.72321765526623e-06 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-24-2-5p BCL2 1.43704663046967 4.34375016509278e-11 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.15947750861285 0.00351654011349327 NA NA NA hsa-miR-29a-5p BCL2 1.89519956688438 1.03453349363915e-11 -0.487496069869486 0.0642113742980754 mirMAP -0.237477310346695 2.67918561276733e-06 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-3065-5p BCL2 0.653308707552535 0.0999497219778851 -0.487496069869486 0.0642113742980754 mirMAP -0.121892398301854 0.000231812969788831 NA NA NA hsa-miR-34a-5p BCL2 1.40588612517769 8.60097477768592e-12 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.185078875528925 0.00135283473559727 22964582;24565525;23155233;24444609;20687223;22623155;24988056;18803879;19714243;25053345;20433755;21399894;23862748 Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression ;drug resistance;;poor survival;drug resistance;;;poor survival;differentiation;poor survival;drug resistance;;; lung cancer;breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;breast cancer;gastric cancer;gastric cancer;pancreatic cancer;prostate cancer;colon cancer;breast cancer;liver cancer hsa-miR-450b-5p BCL2 1.69248953402469 1.96052058003353e-07 -0.487496069869486 0.0642113742980754 mirMAP -0.19720389328785 1.37276161625093e-06 NA NA NA hsa-miR-452-5p BCL2 0.637123950346362 0.0458173998136196 -0.487496069869486 0.0642113742980754 mirMAP -0.123489150343591 0.00113373620964249 NA NA NA hsa-miR-542-3p BCL2 1.62226640768239 2.6427102465476e-10 -0.487496069869486 0.0642113742980754 mirMAP -0.191093289471344 3.49857445479472e-05 NA NA NA hsa-miR-590-5p BCL2 2.07441240363458 4.95240551694843e-14 -0.487496069869486 0.0642113742980754 miRanda -0.183833993408744 0.000541716198465799 NA NA NA hsa-miR-96-5p BCL2 3.0381097138467 4.40362891630201e-24 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;TargetScan -0.137358301513432 0.0019288325262615 NA NA NA hsa-miR-181a-5p BCL2L11 -0.375429731222937 0.0562142867129802 0.413099636208285 0.00142810500164274 miRNAWalker2_validate;miRTarBase;miRNATAP -0.12391370320105 4.5050444704736e-05 23241956;20841506 Mechanistically inactivation of miR-181a elevated the expression of the proapoptotic molecule Bim which sensitized metastatic cells to anoikis;Furthermore we found that cell adhesion-up-regulated miR-181a contributes to FDC-mediated cell survival through Bim down-regulation implicating miR-181a as an upstream effector of the Bim-apoptosis signaling pathway; miR-181a inhibition and Bim upregulation significantly suppressed FDC-mediated protection against apoptosis in lymphoma cell lines and primary lymphoma cells ;poor survival breast cancer;lymphoma hsa-miR-195-5p BCL2L11 -1.01577502605386 4.80814718341729e-05 0.413099636208285 0.00142810500164274 miRNAWalker2_validate -0.100853170407268 5.28659277701771e-05 NA NA NA hsa-miR-221-3p BCL2L11 -0.0986794612964683 0.654454148658401 0.413099636208285 0.00142810500164274 miRNAWalker2_validate -0.109384207626327 5.39590312156036e-05 26503209 Knockdown of miR 221 promotes the cisplatin inducing apoptosis by targeting the BIM Bax/Bak axis in breast cancer breast cancer hsa-miR-30b-5p BCL2L11 0.358144314839612 0.138026229059594 0.413099636208285 0.00142810500164274 miRNATAP -0.127495098127832 2.03752568784222e-07 NA NA NA hsa-miR-30c-5p BCL2L11 -0.327319105755825 0.123595832152687 0.413099636208285 0.00142810500164274 miRNATAP -0.129017782096562 4.09386151557906e-06 NA NA NA hsa-miR-30d-5p BCL2L11 -0.920901858717441 3.50898334321668e-05 0.413099636208285 0.00142810500164274 miRNATAP -0.127929549118207 1.3705250244126e-06 NA NA NA hsa-miR-10a-5p BDNF 0.790595816051606 0.000593731378445468 -3.58120361925577 1.66270299378731e-16 MirTarget;miRNATAP -0.279836886583095 0.00181387070495345 NA NA NA hsa-miR-146b-5p BDNF 1.0922867893808 5.63754607494775e-06 -3.58120361925577 1.66270299378731e-16 miRanda -0.328233255541106 0.000115785817710226 NA NA NA hsa-miR-148a-5p BDNF 1.45633512586855 1.81792463521257e-08 -3.58120361925577 1.66270299378731e-16 mirMAP -0.242376055234495 0.00212193071916532 NA NA NA hsa-miR-155-5p BDNF 0.813513839059142 0.000608282725633232 -3.58120361925577 1.66270299378731e-16 miRNATAP -0.23365712136721 0.00730981706859504 NA NA NA hsa-miR-15a-5p BDNF 1.62575353599172 1.55312121019827e-19 -3.58120361925577 1.66270299378731e-16 MirTarget;miRNATAP -0.299122819876483 0.00718936325191299 26581909 MicroRNA 15a 5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF; BDNF was then overexpressed in HepG2 and SNU-182 cells to evaluate its selective effect on miR-15a-5p in HCC modulation; MiR-15a-5p selectively and negatively regulated BDNF at both gene and protein levels in HCC cells; Forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-15a-5p on HCC proliferation and cell division in vitro; Our study demonstrated that miR-15a-5p is a tumor suppressor in HCC and its regulation is through BDNF in HCC liver cancer hsa-miR-182-5p BDNF 3.21839823004635 5.13049145201115e-39 -3.58120361925577 1.66270299378731e-16 MirTarget;miRNATAP -0.493312713509266 7.77762857641849e-11 NA NA NA hsa-miR-210-3p BDNF 4.89285936864822 4.81769290932762e-28 -3.58120361925577 1.66270299378731e-16 miRNAWalker2_validate;miRTarBase -0.223383828264906 2.32341714099671e-07 NA NA NA hsa-miR-29b-1-5p BDNF 1.71024742617744 3.64915691793611e-09 -3.58120361925577 1.66270299378731e-16 mirMAP -0.254685357058655 0.000278466889584519 NA NA NA hsa-miR-30e-5p BDNF 1.60414100786743 3.78951090573667e-19 -3.58120361925577 1.66270299378731e-16 miRNATAP -0.435874001655586 8.84443032504441e-05 NA NA NA hsa-miR-7-1-3p BDNF 2.61364240402652 1.98959237815786e-32 -3.58120361925577 1.66270299378731e-16 MirTarget -0.301669237992761 0.00109301980491166 NA NA NA hsa-miR-181a-5p BRCA1 -0.375429731222937 0.0562142867129802 1.28846536987094 9.14139284643262e-08 miRNAWalker2_validate -0.390573027244193 4.01647029154172e-12 NA NA NA hsa-miR-199a-5p BRCA1 1.3057193856884 2.38429382751645e-08 1.28846536987094 9.14139284643262e-08 miRanda -0.167186756625212 0.000419975391963386 NA NA NA hsa-miR-199b-5p BRCA1 2.13822205171062 4.56262988762436e-15 1.28846536987094 9.14139284643262e-08 miRanda -0.117610338143603 0.00329627055339426 NA NA NA hsa-miR-320a BRCA1 -0.961144925954715 1.62478794429204e-08 1.28846536987094 9.14139284643262e-08 miRanda -0.258650438000567 7.63550915223519e-05 NA NA NA hsa-miR-106a-5p CCND1 1.3902608059488 6.07931522284525e-05 -0.295767629587253 0.255400743295204 MirTarget;miRNATAP -0.247441760563832 4.58943715400631e-11 NA NA NA hsa-miR-106b-5p CCND1 1.47447672652218 1.32004094930462e-13 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.261384817974007 7.4979419817232e-06 NA NA NA hsa-miR-142-3p CCND1 3.98476449801341 1.56256182021111e-35 -0.295767629587253 0.255400743295204 miRanda -0.119299030581201 0.000532277158339159 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-15a-5p CCND1 1.62575353599172 1.55312121019827e-19 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.199069637483131 0.0019294787514794 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 -1.25935038177398 1.83460220856901e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.303824360423629 3.25741318048184e-06 NA NA NA hsa-miR-16-1-3p CCND1 1.50034693398929 6.63958242991125e-10 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase -0.249107447749185 3.23141967346606e-05 22922827;18483394 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ; sarcoma;lymphoma hsa-miR-16-5p CCND1 0.749619098384047 4.11649450706988e-06 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.371885624299403 3.21606546730418e-07 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-17-5p CCND1 2.07078488653279 2.77403038572568e-19 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.313758634258834 1.59321495552009e-10 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-186-5p CCND1 0.852175445703945 6.88885738584309e-10 -0.295767629587253 0.255400743295204 mirMAP -0.377477028673122 1.06268066352005e-05 NA NA NA hsa-miR-193a-3p CCND1 0.549173467360291 0.0319030569365466 -0.295767629587253 0.255400743295204 MirTarget;PITA;miRanda -0.190950932146342 0.000161171890671323 NA NA NA hsa-miR-193b-3p CCND1 1.10444771306846 0.000822888533401377 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget -0.147999411883792 3.70620495015026e-05 27071318;20655737;20304954;21893020;26129688 MicroRNA 193b inhibits the proliferation migration and invasion of gastric cancer cells via targeting cyclin D1; Further mechanism study indicated that CCND1 was a direct target of miR-193b in GC;CCND1 and ETS1 were revealed to be regulated by miR-193b directly;MicroRNA 193b represses cell proliferation and regulates cyclin D1 in melanoma; Overexpression of miR-193b in Malme-3M cells down-regulated CCND1 mRNA and protein by > or = 50%; A luciferase reporter assay confirmed that miR-193b directly regulates CCND1 by binding to the 3'untranslated region of CCND1 mRNA; These studies indicate that miR-193b represses cell proliferation and regulates CCND1 expression and suggest that dysregulation of miR-193b may play an important role in melanoma development;In a previous study we reported that miR-193b represses cell proliferation and regulates cyclin D1 in melanoma cells suggesting that miR-193b could act as a tumor suppressor;Epigenetically altered miR 193b targets cyclin D1 in prostate cancer; It has been suggested that miR-193b targets cyclin D1 in several malignancies; Here our aim was to determine if miR-193b targets cyclin D1 in prostate cancer; Furthermore the PC cell lines 22Rv1 and VCaP which express low levels of miR-193b and high levels of CCND1 showed significant growth retardation when treated with a CDK4/6 inhibitor; In contrast the inhibitor had no effect on the growth of PC-3 and DU145 cells with high miR-193b and low CCND1 expression; Taken together our data demonstrate that miR-193b targets cyclin D1 in prostate cancer ;;;; gastric cancer;liver cancer;melanoma;melanoma;prostate cancer hsa-miR-19a-3p CCND1 2.11776595911517 7.07663078397156e-10 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;miRNATAP -0.21539529985992 9.86203433305448e-08 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 1.71217036351784 3.28561659177495e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase -0.301713494105536 2.89182846291565e-08 NA NA NA hsa-miR-19b-3p CCND1 2.10868505662119 5.40846613768389e-17 -0.295767629587253 0.255400743295204 miRNATAP -0.179773518063806 0.000197856717032667 NA NA NA hsa-miR-20a-5p CCND1 2.64649625616975 5.1469418982085e-27 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.237160136465301 1.84669386058676e-07 NA NA NA hsa-miR-20b-5p CCND1 1.35770573270947 0.00260808530013016 -0.295767629587253 0.255400743295204 MirTarget;miRNATAP -0.179107595068828 5.65966117118738e-11 NA NA NA hsa-miR-365a-3p CCND1 0.0132777124336201 0.953597412537431 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase -0.193166924738263 0.000234492957903034 NA NA NA hsa-miR-374a-5p CCND1 -0.197027254874826 0.298080902192861 -0.295767629587253 0.255400743295204 MirTarget -0.313785702713176 9.54081268797886e-06 27191497 microRNA 374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway; Furthermore luciferase reporter assays confirmed that miR-374a could directly reduce CCND1; We examined miR-374a levels by in situ hybridization and its correlation with CCND1 expression in CRC tumor tissues; High miR-374a expression with low level of CCND1 was protective factor in CRC; Together these findings indicate that miR-374a inactivates the PI3K/AKT axis by inhibiting CCND1 suppressing of colon cancer progression progression colon cancer hsa-miR-374b-5p CCND1 0.474691035780475 0.0109217471394203 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget -0.26116225100222 0.00011561978488339 NA NA NA hsa-miR-425-5p CCND1 1.21659524959201 8.01126418494715e-09 -0.295767629587253 0.255400743295204 miRNAWalker2_validate -0.245575402525843 1.03844251357893e-05 NA NA NA hsa-miR-589-3p CCND1 1.34253876396688 1.84935927493927e-05 -0.295767629587253 0.255400743295204 MirTarget -0.130907472589194 0.000793150025378685 NA NA NA hsa-miR-590-3p CCND1 0.83851360565783 0.00129224433453587 -0.295767629587253 0.255400743295204 mirMAP -0.182941292569374 0.000856336828554768 NA NA NA hsa-miR-769-3p CCND1 0.452126659761753 0.0748150639143322 -0.295767629587253 0.255400743295204 mirMAP -0.142316943866129 0.00276805281261241 NA NA NA hsa-miR-92a-3p CCND1 -0.136362762339122 0.493412263619364 -0.295767629587253 0.255400743295204 miRNAWalker2_validate -0.337251172229938 1.62058605849004e-08 NA NA NA hsa-miR-93-5p CCND1 1.50844106515467 1.83836866996875e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget;miRNATAP -0.320397820083252 2.84014735439528e-09 NA NA NA hsa-miR-942-5p CCND1 -0.0372813055050076 0.870631058767894 -0.295767629587253 0.255400743295204 MirTarget -0.177314558661089 0.000979800060419363 NA NA NA hsa-miR-106a-5p CCND2 1.3902608059488 6.07931522284525e-05 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.149132151233025 1.88464236882735e-05 NA NA NA hsa-miR-106b-5p CCND2 1.47447672652218 1.32004094930462e-13 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.383655587509124 2.65429916887189e-13 NA NA NA hsa-miR-130b-5p CCND2 1.53645187062942 1.10498816261505e-08 -1.64140990579885 1.49666938681079e-12 mirMAP -0.268032769997331 9.22343432530747e-12 NA NA NA hsa-miR-141-3p CCND2 3.36993755486106 5.42939251147195e-32 -1.64140990579885 1.49666938681079e-12 MirTarget;TargetScan -0.239914655059016 6.4654039095017e-12 NA NA NA hsa-miR-151a-3p CCND2 0.665271883054405 0.000281673348137154 -1.64140990579885 1.49666938681079e-12 mirMAP -0.279142680983949 2.60564778780149e-06 NA NA NA hsa-miR-15a-5p CCND2 1.62575353599172 1.55312121019827e-19 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.158338209854594 0.00711668272045409 NA NA NA hsa-miR-17-5p CCND2 2.07078488653279 2.77403038572568e-19 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.365048259055278 1.61934056872758e-16 NA NA NA hsa-miR-182-5p CCND2 3.21839823004635 5.13049145201115e-39 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.373145719566719 1.32597677460149e-21 NA NA NA hsa-miR-183-5p CCND2 2.39247234736657 3.92444525331999e-21 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.410520271082553 1.11291256348519e-25 NA NA NA hsa-miR-185-5p CCND2 1.14291034858482 2.95777119743491e-13 -1.64140990579885 1.49666938681079e-12 MirTarget;miRNATAP -0.23940712387784 0.000484175543966546 NA NA NA hsa-miR-186-5p CCND2 0.852175445703945 6.88885738584309e-10 -1.64140990579885 1.49666938681079e-12 mirMAP;miRNATAP -0.357370184588874 5.14493635358813e-06 NA NA NA hsa-miR-191-5p CCND2 0.343645878547116 0.0668114086143391 -1.64140990579885 1.49666938681079e-12 MirTarget -0.19767765908675 0.000750401585158583 NA NA NA hsa-miR-19a-3p CCND2 2.11776595911517 7.07663078397156e-10 -1.64140990579885 1.49666938681079e-12 MirTarget;miRNATAP -0.167455065978335 6.56621464464812e-06 NA NA NA hsa-miR-19b-3p CCND2 2.10868505662119 5.40846613768389e-17 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.19157786848984 1.39328108679414e-05 NA NA NA hsa-miR-200a-3p CCND2 3.14766878548496 1.32850889777422e-21 -1.64140990579885 1.49666938681079e-12 MirTarget -0.173744823500602 6.53232158053391e-08 NA NA NA hsa-miR-20a-5p CCND2 2.64649625616975 5.1469418982085e-27 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.28367508352758 5.6750334332974e-12 NA NA NA hsa-miR-21-3p CCND2 2.54206008030157 1.11598785398763e-30 -1.64140990579885 1.49666938681079e-12 mirMAP -0.212907340098529 4.00646631535515e-06 NA NA NA hsa-miR-2355-3p CCND2 1.10676344164715 6.24068383465151e-06 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.221166273655799 1.96123873319489e-06 NA NA NA hsa-miR-28-5p CCND2 1.19639196514745 4.59365801666536e-18 -1.64140990579885 1.49666938681079e-12 miRanda -0.289410618824274 0.00017592467355866 NA NA NA hsa-miR-301a-3p CCND2 2.70198002906399 1.56420889710984e-14 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate -0.265639128307335 3.9945374923581e-13 NA NA NA hsa-miR-320b CCND2 0.226640952564488 0.378818692487242 -1.64140990579885 1.49666938681079e-12 mirMAP;miRNATAP -0.123605256651271 0.00373003525561283 NA NA NA hsa-miR-324-3p CCND2 -0.0774700133118458 0.689226297032231 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate -0.276159423764137 9.9462768745637e-07 NA NA NA hsa-miR-331-5p CCND2 0.578237334664505 0.00131211239210882 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.275952758002927 9.36107182529594e-06 NA NA NA hsa-miR-429 CCND2 2.3794516574089 1.72813419703734e-13 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.209322906628109 2.95963655497587e-09 NA NA NA hsa-miR-450b-5p CCND2 1.69248953402469 1.96052058003353e-07 -1.64140990579885 1.49666938681079e-12 MirTarget;PITA;miRNATAP -0.145422700655101 8.53356735526403e-05 NA NA NA hsa-miR-501-5p CCND2 0.411357595674671 0.10435288464149 -1.64140990579885 1.49666938681079e-12 PITA;mirMAP;miRNATAP -0.144149908130612 0.000856140982438327 NA NA NA hsa-miR-503-5p CCND2 1.97129438815516 2.1704434283035e-09 -1.64140990579885 1.49666938681079e-12 MirTarget -0.132569636435255 4.69239346000773e-05 25860935 We then identified two targets of miR-503 CCND2 and CCND3 breast cancer hsa-miR-550a-5p CCND2 0.59977150019756 0.0314775340172755 -1.64140990579885 1.49666938681079e-12 MirTarget -0.220699899618513 1.33146855439522e-08 NA NA NA hsa-miR-589-3p CCND2 1.34253876396688 1.84935927493927e-05 -1.64140990579885 1.49666938681079e-12 mirMAP -0.194613807523332 3.68596504229146e-08 NA NA NA hsa-miR-590-3p CCND2 0.83851360565783 0.00129224433453587 -1.64140990579885 1.49666938681079e-12 miRanda;mirMAP -0.133052154455084 0.00820830741469702 NA NA NA hsa-miR-590-5p CCND2 2.07441240363458 4.95240551694843e-14 -1.64140990579885 1.49666938681079e-12 mirMAP -0.258740782004531 5.16823341358779e-08 NA NA NA hsa-miR-660-5p CCND2 2.04875198906126 1.08269480928897e-17 -1.64140990579885 1.49666938681079e-12 mirMAP -0.145565210932688 0.00131443056428649 NA NA NA hsa-miR-7-1-3p CCND2 2.61364240402652 1.98959237815786e-32 -1.64140990579885 1.49666938681079e-12 mirMAP -0.259792711431322 7.83559584811719e-08 NA NA NA hsa-miR-877-5p CCND2 -0.370234513208225 0.20670834111988 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate -0.150269749089241 5.7135351515868e-05 NA NA NA hsa-miR-93-5p CCND2 1.50844106515467 1.83836866996875e-12 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.414585687663892 1.04746846150745e-17 NA NA NA hsa-miR-96-5p CCND2 3.0381097138467 4.40362891630201e-24 -1.64140990579885 1.49666938681079e-12 TargetScan;miRNATAP -0.357833634781266 1.13611538125112e-20 NA NA NA hsa-miR-320b CCND3 0.226640952564488 0.378818692487242 -0.858556164090156 9.93688486289821e-06 miRanda -0.106740567141186 0.00235090988932412 NA NA NA hsa-miR-421 CCND3 0.170525317701774 0.535277026680289 -0.858556164090156 9.93688486289821e-06 PITA;miRanda -0.120402813664522 0.000730915299268324 NA NA NA hsa-miR-96-5p CCND3 3.0381097138467 4.40362891630201e-24 -0.858556164090156 9.93688486289821e-06 TargetScan -0.12470872406597 0.000146574618288945 NA NA NA hsa-miR-125b-5p CCNE1 -0.548859243919575 0.0107224406584463 2.99717740665025 1.61069658019784e-19 miRNAWalker2_validate -0.212969225547095 0.00407731324503497 NA NA NA hsa-miR-195-5p CCNE1 -1.01577502605386 4.80814718341729e-05 2.99717740665025 1.61069658019784e-19 miRNAWalker2_validate;MirTarget;miRNATAP -0.51804360034979 1.42698078497522e-15 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-26a-5p CCNE1 -0.126411409001078 0.440028840408711 2.99717740665025 1.61069658019784e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.695101497950461 4.5037170303388e-13 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-497-5p CCNE1 -0.0546347378264729 0.786205564901684 2.99717740665025 1.61069658019784e-19 MirTarget;miRNATAP -0.495681038343954 2.32850749141189e-10 25909221;24112607;24909281 The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells;Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1 ;; lung cancer;breast cancer;cervical and endocervical cancer hsa-let-7a-3p CCNE2 0.167285443861993 0.431834813181487 2.14869777933212 3.82193505863706e-13 mirMAP -0.219072556802333 0.00307083362438944 NA NA NA hsa-let-7b-3p CCNE2 -1.81889978084306 6.9913416210266e-19 2.14869777933212 3.82193505863706e-13 mirMAP -0.490706485648775 1.99669157811241e-14 NA NA NA hsa-miR-126-3p CCNE2 0.397563736477277 0.115641762947829 2.14869777933212 3.82193505863706e-13 miRNAWalker2_validate -0.150847603483629 0.0065596481993981 NA NA NA hsa-miR-26a-5p CCNE2 -0.126411409001078 0.440028840408711 2.14869777933212 3.82193505863706e-13 miRNAWalker2_validate;miRTarBase;miRNATAP -0.509665959363437 2.11729025570925e-09 24116110;21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression poor survival;progression pancreatic cancer;acute myeloid leukemia hsa-miR-26b-5p CCNE2 0.72362441215247 4.7794659748036e-05 2.14869777933212 3.82193505863706e-13 miRNATAP -0.221903049454022 0.0047653538397741 NA NA NA hsa-miR-3065-5p CCNE2 0.653308707552535 0.0999497219778851 2.14869777933212 3.82193505863706e-13 mirMAP -0.199731594807246 1.35834639539203e-07 NA NA NA hsa-miR-30a-5p CCNE2 -0.924084264430689 0.000762030454634728 2.14869777933212 3.82193505863706e-13 miRNATAP -0.485926886026448 9.30670075166704e-24 NA NA NA hsa-miR-30b-5p CCNE2 0.358144314839612 0.138026229059594 2.14869777933212 3.82193505863706e-13 miRNAWalker2_validate;miRTarBase -0.201650464117881 0.000503320898048745 22384020 A luciferase-based reporter assay demonstrated that miR-30b post-transcriptionally reduced 27% p = 0.005 of the gene expression by interacting with two binding sites in the 3'-UTR of CCNE2; The upregulation of miR-30b by trastuzumab may play a biological role in trastuzumab-induced cell growth inhibition by targeting CCNE2 breast cancer hsa-miR-30c-5p CCNE2 -0.327319105755825 0.123595832152687 2.14869777933212 3.82193505863706e-13 miRNATAP -0.441580113864178 9.21074303399811e-12 NA NA NA hsa-miR-30d-5p CCNE2 -0.920901858717441 3.50898334321668e-05 2.14869777933212 3.82193505863706e-13 miRNATAP -0.348831475795763 1.65705272947657e-08 25843294 MicroRNA 30d 5p inhibits tumour cell proliferation and motility by directly targeting CCNE2 in non small cell lung cancer; In addition the re-introduction of CCNE2 expression antagonised the inhibitory effects of miR-30d-5p on the capacity of NSCLC cells for proliferation and motility motility lung squamous cell cancer hsa-miR-34a-5p CCNE2 1.40588612517769 8.60097477768592e-12 2.14869777933212 3.82193505863706e-13 miRNAWalker2_validate;miRTarBase;miRNATAP -0.195460410714665 0.00336778531948037 NA NA NA hsa-miR-34c-5p CCNE2 -1.00125440032112 0.0724432896090357 2.14869777933212 3.82193505863706e-13 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.107375543427311 4.3380723232889e-05 NA NA NA hsa-miR-514a-3p CCNE2 -0.62130231811134 0.313738530078239 2.14869777933212 3.82193505863706e-13 miRNATAP -0.174092237043764 3.53454317603187e-12 NA NA NA hsa-miR-23b-3p CDK2 -0.070273068040148 0.620585267977425 0.335081436185588 0.0196934506015732 miRNAWalker2_validate -0.320796841599285 4.19225271403267e-12 NA NA NA hsa-miR-26b-5p CDK2 0.72362441215247 4.7794659748036e-05 0.335081436185588 0.0196934506015732 miRNAWalker2_validate -0.127461620300032 0.000584290801690183 NA NA NA hsa-miR-145-5p CDK4 -1.34926078156437 2.63526538800669e-07 0.737437814725925 6.46735685355202e-06 miRNAWalker2_validate;miRTarBase -0.151032894863878 9.5680433026529e-08 21092188 Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control lung squamous cell cancer hsa-miR-195-5p CDK4 -1.01577502605386 4.80814718341729e-05 0.737437814725925 6.46735685355202e-06 miRNAWalker2_validate;miRTarBase -0.113117227761123 0.000369485847021713 NA NA NA hsa-miR-320a CDK4 -0.961144925954715 1.62478794429204e-08 0.737437814725925 6.46735685355202e-06 miRNAWalker2_validate -0.198117291941419 6.62226154091084e-06 NA NA NA hsa-miR-141-3p CDK6 3.36993755486106 5.42939251147195e-32 -0.634679756888932 0.0174689602657709 TargetScan;miRNATAP -0.160612180698081 5.76268904101641e-05 NA NA NA hsa-miR-148a-3p CDK6 2.30885799126944 1.95226081368985e-21 -0.634679756888932 0.0174689602657709 mirMAP -0.140512406763982 0.00377970382659687 NA NA NA hsa-miR-15a-5p CDK6 1.62575353599172 1.55312121019827e-19 -0.634679756888932 0.0174689602657709 miRNATAP -0.213028438155036 0.00125907527826487 NA NA NA hsa-miR-16-1-3p CDK6 1.50034693398929 6.63958242991125e-10 -0.634679756888932 0.0174689602657709 mirMAP -0.187334541166986 0.00249778145407185 NA NA NA hsa-miR-182-5p CDK6 3.21839823004635 5.13049145201115e-39 -0.634679756888932 0.0174689602657709 mirMAP -0.195465673682201 1.86720454693084e-05 NA NA NA hsa-miR-200a-3p CDK6 3.14766878548496 1.32850889777422e-21 -0.634679756888932 0.0174689602657709 miRNATAP -0.172932973424539 1.8796595520804e-06 24009066 microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6 liver cancer hsa-miR-200b-3p CDK6 1.55157578247391 4.83790020897188e-09 -0.634679756888932 0.0174689602657709 mirMAP -0.168627583367613 0.000217208517169461 NA NA NA hsa-miR-21-5p CDK6 4.38165933891779 1.52536633902505e-92 -0.634679756888932 0.0174689602657709 miRNAWalker2_validate;mirMAP -0.148024006269382 0.00157509032784336 NA NA NA hsa-miR-23b-3p CDK6 -0.070273068040148 0.620585267977425 -0.634679756888932 0.0174689602657709 mirMAP -0.23876595315757 0.0067366952470222 NA NA NA hsa-miR-27b-3p CDK6 0.236438984240408 0.12263510345883 -0.634679756888932 0.0174689602657709 mirMAP -0.290275286674932 0.000346874480244186 NA NA NA hsa-miR-27b-5p CDK6 1.03511957999268 7.86187917705303e-11 -0.634679756888932 0.0174689602657709 mirMAP -0.218863599231384 0.00422822542967776 NA NA NA hsa-miR-29b-3p CDK6 3.10527711861309 3.01242507282711e-32 -0.634679756888932 0.0174689602657709 miRNAWalker2_validate;miRTarBase;miRNATAP -0.177579122887668 4.47727335928492e-05 23591808;23245396;25472644;26180082;27230400;20086245 Here we have identified the oncogene cyclin-dependent protein kinase 6 CDK6 as a direct target of miR-29b in lung cancer;The IFN-γ-induced G1-arrest of melanoma cells involves down-regulation of CDK6 which we proved to be a direct target of miR-29 in these cells;Moreover miR-29b inhibited the expression of MCL1 and CDK6;Knockdown of NTSR1 increased the expression of miR-29b-1 and miR-129-3p which were responsible for the decreased CDK6 expression;MiR 29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6; In this study we investigated the role of miR-29b as a novel regulator of CDK6 using bioinformatics methods; We demonstrated that CDK6 can be downregulated by miR-29b via binding to the 3'-UTR region in osteosarcoma cells; Furthermore we identified an inverse correlation between miR-29b and CDK6 protein levels in osteosarcoma tissues; The results revealed that miR-29b acts as a tumor suppressor of osteosarcoma by targeting CDK6 in the proliferation and migration processes;microRNA expression profile and identification of miR 29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma; Furthermore we demonstrate miR-29 inhibition of CDK6 protein and mRNA levels by direct binding to 3'-untranslated region; Inverse correlation between miR-29 and CDK6 was observed in MCL ;;;;; lung cancer;melanoma;colorectal cancer;glioblastoma;sarcoma;lymphoma hsa-miR-3065-5p CDK6 0.653308707552535 0.0999497219778851 -0.634679756888932 0.0174689602657709 mirMAP -0.22642349631217 6.97387440613112e-12 NA NA NA hsa-miR-30b-5p CDK6 0.358144314839612 0.138026229059594 -0.634679756888932 0.0174689602657709 mirMAP -0.297003306946081 3.8128721932856e-09 NA NA NA hsa-miR-30c-5p CDK6 -0.327319105755825 0.123595832152687 -0.634679756888932 0.0174689602657709 mirMAP -0.164968126318733 0.0045742419018014 NA NA NA hsa-miR-30d-3p CDK6 0.00396376345349925 0.986457040013182 -0.634679756888932 0.0174689602657709 mirMAP -0.371507952440074 1.92927097384112e-10 NA NA NA hsa-miR-30d-5p CDK6 -0.920901858717441 3.50898334321668e-05 -0.634679756888932 0.0174689602657709 mirMAP -0.319235369499537 4.17247463199845e-09 NA NA NA hsa-miR-30e-5p CDK6 1.60414100786743 3.78951090573667e-19 -0.634679756888932 0.0174689602657709 mirMAP -0.286452484165894 1.41651230242754e-05 NA NA NA hsa-miR-338-3p CDK6 0.726843067232002 0.0506251324215494 -0.634679756888932 0.0174689602657709 mirMAP -0.154832977052286 2.36104508154558e-06 NA NA NA hsa-miR-34a-5p CDK6 1.40588612517769 8.60097477768592e-12 -0.634679756888932 0.0174689602657709 miRNAWalker2_validate;miRTarBase;miRNATAP -0.243763697376835 2.99239665927089e-05 26104764;21702042 The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004;Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization ; lung cancer;bladder cancer hsa-miR-362-5p CDK6 0.658947634569393 0.0243306847205756 -0.634679756888932 0.0174689602657709 mirMAP -0.182028148769008 2.22030118459272e-05 NA NA NA hsa-miR-429 CDK6 2.3794516574089 1.72813419703734e-13 -0.634679756888932 0.0174689602657709 mirMAP;miRNATAP -0.15019667316567 0.000181432042876184 NA NA NA hsa-miR-660-5p CDK6 2.04875198906126 1.08269480928897e-17 -0.634679756888932 0.0174689602657709 mirMAP -0.160480938026846 0.00163906606751145 NA NA NA hsa-miR-664a-3p CDK6 0.443077463053857 0.0214248925850984 -0.634679756888932 0.0174689602657709 mirMAP -0.300162344123568 2.48177468084385e-06 NA NA NA hsa-miR-106b-5p CDKN1A 1.47447672652218 1.32004094930462e-13 -0.989660104023605 3.33169106596478e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.227776235142808 2.11586866823657e-07 NA NA NA hsa-miR-17-5p CDKN1A 2.07078488653279 2.77403038572568e-19 -0.989660104023605 3.33169106596478e-07 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.155626227970113 3.32801748379634e-05 26482648;24989082 The low expressions of miR-17 and miR-92 families can maintain cisplatin resistance through the regulation of CDKN1A and RAD21;According to PicTar and Miranda algorithms which predicted CDKN1A p21 as a putative target of miR-17 a luciferase assay was performed and revealed that miR-17 directly targets the 3'-UTR of p21 mRNA drug resistance; lung squamous cell cancer;sarcoma hsa-miR-182-5p CDKN1A 3.21839823004635 5.13049145201115e-39 -0.989660104023605 3.33169106596478e-07 miRNAWalker2_validate -0.191273978004266 8.63402331622284e-09 NA NA NA hsa-miR-20a-5p CDKN1A 2.64649625616975 5.1469418982085e-27 -0.989660104023605 3.33169106596478e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.137674450234877 6.74026700667366e-05 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex colon cancer hsa-miR-28-5p CDKN1A 1.19639196514745 4.59365801666536e-18 -0.989660104023605 3.33169106596478e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.202389894871562 0.0015056884290614 NA NA NA hsa-miR-93-5p CDKN1A 1.50844106515467 1.83836866996875e-12 -0.989660104023605 3.33169106596478e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.165683989353739 5.62354734150849e-05 25633810 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC liver cancer hsa-miR-96-5p CDKN1A 3.0381097138467 4.40362891630201e-24 -0.989660104023605 3.33169106596478e-07 miRNAWalker2_validate;miRTarBase -0.146610096725374 7.80340952179366e-06 26582573 Upregulation of microRNA 96 and its oncogenic functions by targeting CDKN1A in bladder cancer; Bioinformatics prediction combined with luciferase reporter assay were used to verify whether the cyclin-dependent kinase inhibitor CDKN1A was a potential target gene of miR-96; According to the data of miRTarBase CDKN1A might be a candidate target gene of miR-96; In addition luciferase reporter and Western blot assays respectively demonstrated that miR-96 could bind to the putative seed region in CDKN1A mRNA 3'UTR and significantly reduce the expression level of CDKN1A protein; Moreover we found that the inhibition of miR-96 expression remarkably decreased cell proliferation and promoted cell apoptosis of BC cell lines which was consistent with the findings observed following the introduction of CDKN1A cDNA without 3'UTR restored miR-96; Upregulation of miR-96 may contribute to aggressive malignancy partly through suppressing CDKN1A protein expression in BC cells bladder cancer hsa-miR-221-5p CHAD -2.2173523967387 1.8954728277084e-09 1.1140829583863 0.0145499843221945 MirTarget -0.228499751662939 7.13111642159933e-05 NA NA NA hsa-miR-27a-3p CHRM1 0.433402568013802 0.00737164631768323 -4.86780337391153 7.83920856723402e-22 miRNATAP -0.40078169455824 0.00861592992207417 NA NA NA hsa-miR-15a-5p CHUK 1.62575353599172 1.55312121019827e-19 0.0377297766878195 0.74424413982199 miRNAWalker2_validate;miRTarBase;MirTarget -0.156480048093973 2.55421092282135e-08 NA NA NA hsa-miR-29b-2-5p CHUK 0.345881055247341 0.194842633194187 0.0377297766878195 0.74424413982199 MirTarget -0.119533869512923 1.02102108327589e-09 NA NA NA hsa-miR-339-5p CHUK 0.536997313601114 0.0488090394176611 0.0377297766878195 0.74424413982199 miRanda -0.101676919866514 1.24374098863621e-07 NA NA NA hsa-miR-342-3p CHUK -0.128691966564961 0.561034080130801 0.0377297766878195 0.74424413982199 miRanda -0.176769532720248 4.41422217910121e-14 NA NA NA hsa-miR-497-5p CHUK -0.0546347378264729 0.786205564901684 0.0377297766878195 0.74424413982199 MirTarget -0.194599570543196 4.42801403790986e-14 NA NA NA hsa-let-7a-5p COL1A1 -1.37014061604018 3.11451492971224e-14 2.42065146814761 3.39003531025036e-11 TargetScan;miRNATAP -0.596721970344643 6.93515424395411e-11 NA NA NA hsa-let-7b-5p COL1A1 -1.62016148171663 1.56547487335694e-15 2.42065146814761 3.39003531025036e-11 miRNATAP -0.29948836737854 0.000262649270813065 NA NA NA hsa-let-7d-5p COL1A1 -0.618145137285851 6.06067642715858e-05 2.42065146814761 3.39003531025036e-11 miRNATAP -0.555394166436726 5.59530512629896e-07 NA NA NA hsa-let-7f-5p COL1A1 -0.0523311272618407 0.83407808268787 2.42065146814761 3.39003531025036e-11 miRNATAP -0.352705898260858 2.48056064656299e-07 NA NA NA hsa-let-7g-5p COL1A1 0.0837630831079359 0.583083118232597 2.42065146814761 3.39003531025036e-11 miRNATAP -0.569787034491876 4.66938321096021e-07 NA NA NA hsa-miR-107 COL1A1 0.658676029898313 5.11480446318819e-07 2.42065146814761 3.39003531025036e-11 PITA;miRanda -0.66134725787987 4.00003936521905e-07 NA NA NA hsa-miR-133a-3p COL1A1 -2.89609207852024 1.71222048144972e-13 2.42065146814761 3.39003531025036e-11 miRNAWalker2_validate -0.138993476526241 0.00112688010552943 NA NA NA hsa-miR-30a-3p COL1A1 -2.54042202792785 2.9111625410859e-18 2.42065146814761 3.39003531025036e-11 mirMAP -0.435571026514716 2.87112040151015e-15 NA NA NA hsa-miR-30b-3p COL1A1 -1.20976737190106 2.63726511331003e-06 2.42065146814761 3.39003531025036e-11 miRNATAP -0.364433820785245 2.55880839848639e-08 NA NA NA hsa-miR-30d-3p COL1A1 0.00396376345349925 0.986457040013182 2.42065146814761 3.39003531025036e-11 mirMAP -0.592265244784086 2.46968154677536e-13 NA NA NA hsa-miR-30e-3p COL1A1 -0.104420043859122 0.526240453209293 2.42065146814761 3.39003531025036e-11 mirMAP -0.555277449194079 1.02221283405107e-07 NA NA NA hsa-miR-330-3p COL1A1 -0.716924999893351 0.000796236278616087 2.42065146814761 3.39003531025036e-11 mirMAP -0.315399409772296 8.16900883661461e-05 NA NA NA hsa-miR-338-3p COL1A1 0.726843067232002 0.0506251324215494 2.42065146814761 3.39003531025036e-11 miRanda;miRNATAP -0.178951913488227 9.9215993656662e-05 NA NA NA hsa-miR-361-3p COL1A1 0.0988926195529967 0.549128728500555 2.42065146814761 3.39003531025036e-11 PITA -0.323853876550334 0.00207476620275568 NA NA NA hsa-miR-92a-1-5p COL1A1 -0.206144909572847 0.487857247338839 2.42065146814761 3.39003531025036e-11 MirTarget -0.164842138542065 0.00578612315198288 NA NA NA hsa-let-7a-5p COL1A2 -1.37014061604018 3.11451492971224e-14 0.876118168211992 0.00368711342738012 MirTarget;TargetScan;miRNATAP -0.241702341970535 0.00135789667212977 NA NA NA hsa-let-7d-5p COL1A2 -0.618145137285851 6.06067642715858e-05 0.876118168211992 0.00368711342738012 MirTarget;miRNATAP -0.355761625090553 8.33642750132082e-05 NA NA NA hsa-let-7f-5p COL1A2 -0.0523311272618407 0.83407808268787 0.876118168211992 0.00368711342738012 MirTarget;miRNATAP -0.201184305177655 0.000313423714809636 NA NA NA hsa-let-7g-5p COL1A2 0.0837630831079359 0.583083118232597 0.876118168211992 0.00368711342738012 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.378077277130448 4.02146869124637e-05 NA NA NA hsa-miR-19b-3p COL1A2 2.10868505662119 5.40846613768389e-17 0.876118168211992 0.00368711342738012 MirTarget -0.148917788523693 0.00837087535968672 NA NA NA hsa-miR-25-3p COL1A2 0.361927330834176 0.0163670566170988 0.876118168211992 0.00368711342738012 MirTarget;miRNATAP -0.388368128679851 2.92439361890388e-05 NA NA NA hsa-miR-26a-5p COL1A2 -0.126411409001078 0.440028840408711 0.876118168211992 0.00368711342738012 MirTarget;miRNATAP -0.253542314755959 0.00320050316582886 NA NA NA hsa-miR-26b-5p COL1A2 0.72362441215247 4.7794659748036e-05 0.876118168211992 0.00368711342738012 MirTarget;miRNATAP -0.281535684852185 0.000312672991159713 NA NA NA hsa-miR-29a-3p COL1A2 0.101650412194573 0.573201097011668 0.876118168211992 0.00368711342738012 miRNATAP -0.203669541999129 0.00897188032974133 NA NA NA hsa-miR-30a-3p COL1A2 -2.54042202792785 2.9111625410859e-18 0.876118168211992 0.00368711342738012 MirTarget -0.230071837954876 4.51147879508592e-07 NA NA NA hsa-miR-30d-3p COL1A2 0.00396376345349925 0.986457040013182 0.876118168211992 0.00368711342738012 MirTarget -0.473963376561583 5.15302527439975e-13 NA NA NA hsa-miR-30e-3p COL1A2 -0.104420043859122 0.526240453209293 0.876118168211992 0.00368711342738012 MirTarget -0.39466193610838 3.31645249106772e-06 NA NA NA hsa-miR-32-5p COL1A2 0.876853679269853 6.04859399018691e-05 0.876118168211992 0.00368711342738012 MirTarget;miRNATAP -0.26757902412027 9.88080962911513e-05 NA NA NA hsa-miR-3934-5p COL1A2 0.0322530814975441 0.910284056659068 0.876118168211992 0.00368711342738012 MirTarget -0.235659314209142 4.73939812028552e-06 NA NA NA hsa-miR-500a-5p COL1A2 0.648155655714409 0.0104657432932038 0.876118168211992 0.00368711342738012 miRNATAP -0.199136328717997 0.000414600401117691 NA NA NA hsa-miR-92a-3p COL1A2 -0.136362762339122 0.493412263619364 0.876118168211992 0.00368711342738012 MirTarget;miRNATAP -0.277447300018764 7.67027357501172e-05 NA NA NA hsa-miR-29a-3p COL2A1 0.101650412194573 0.573201097011668 0.800404256980403 0.253931653233489 MirTarget;miRNATAP -0.954134177560321 9.14432694156841e-08 NA NA NA hsa-miR-29b-3p COL2A1 3.10527711861309 3.01242507282711e-32 0.800404256980403 0.253931653233489 MirTarget;miRNATAP -0.403046624700214 0.000426210506374599 NA NA NA hsa-miR-29c-3p COL2A1 1.32354490728858 1.84279305179762e-07 0.800404256980403 0.253931653233489 MirTarget;miRNATAP -0.465654516156544 0.000205750121150287 NA NA NA hsa-miR-514a-3p COL2A1 -0.62130231811134 0.313738530078239 0.800404256980403 0.253931653233489 MirTarget;miRNATAP -0.166133734875681 0.00490199368979589 NA NA NA hsa-let-7f-5p COL4A1 -0.0523311272618407 0.83407808268787 -0.171188584989235 0.444957041661407 miRNATAP -0.119613217283808 0.00383589608321452 NA NA NA hsa-let-7g-5p COL4A1 0.0837630831079359 0.583083118232597 -0.171188584989235 0.444957041661407 miRNATAP -0.24497162186823 0.000328807573938744 NA NA NA hsa-miR-16-5p COL4A1 0.749619098384047 4.11649450706988e-06 -0.171188584989235 0.444957041661407 miRNAWalker2_validate -0.305665949761596 1.10858365302114e-06 NA NA NA hsa-miR-29a-3p COL4A1 0.101650412194573 0.573201097011668 -0.171188584989235 0.444957041661407 miRNAWalker2_validate;miRTarBase;miRNATAP -0.231277342972376 5.47658398396484e-05 NA NA NA hsa-miR-29b-3p COL4A1 3.10527711861309 3.01242507282711e-32 -0.171188584989235 0.444957041661407 miRNAWalker2_validate;miRTarBase;miRNATAP -0.169878075822688 2.87223680838542e-06 NA NA NA hsa-miR-29c-3p COL4A1 1.32354490728858 1.84279305179762e-07 -0.171188584989235 0.444957041661407 miRNAWalker2_validate;miRTarBase;miRNATAP -0.183472319048058 4.15003522961556e-06 NA NA NA hsa-miR-3065-5p COL4A1 0.653308707552535 0.0999497219778851 -0.171188584989235 0.444957041661407 miRNATAP -0.135591684821414 1.24639892231323e-06 NA NA NA hsa-miR-362-3p COL4A1 0.194097672030785 0.52808475179225 -0.171188584989235 0.444957041661407 miRanda -0.134753411115438 0.00129947643192595 NA NA NA hsa-miR-429 COL4A1 2.3794516574089 1.72813419703734e-13 -0.171188584989235 0.444957041661407 miRanda;miRNATAP -0.194737605606394 4.50254748904607e-09 NA NA NA hsa-miR-628-5p COL4A1 1.06173574237323 4.67541261016756e-06 -0.171188584989235 0.444957041661407 PITA;miRNATAP -0.137894538435734 0.00915566627512573 NA NA NA hsa-let-7f-5p COL4A2 -0.0523311272618407 0.83407808268787 -0.618750645591112 0.00595258274491188 miRNATAP -0.174516107539413 2.57998374267252e-05 NA NA NA hsa-let-7g-5p COL4A2 0.0837630831079359 0.583083118232597 -0.618750645591112 0.00595258274491188 miRNATAP -0.280315504842131 4.36950007027574e-05 NA NA NA hsa-miR-1266-5p COL4A2 -0.289721391624349 0.281500764553995 -0.618750645591112 0.00595258274491188 MirTarget -0.102157435637751 0.0082695589651559 NA NA NA hsa-miR-16-5p COL4A2 0.749619098384047 4.11649450706988e-06 -0.618750645591112 0.00595258274491188 miRNAWalker2_validate -0.32451853983148 2.74433880065982e-07 NA NA NA hsa-miR-26b-5p COL4A2 0.72362441215247 4.7794659748036e-05 -0.618750645591112 0.00595258274491188 miRNAWalker2_validate -0.235865417887102 4.86776153058155e-05 NA NA NA hsa-miR-29a-3p COL4A2 0.101650412194573 0.573201097011668 -0.618750645591112 0.00595258274491188 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.239057796585856 3.4644745560624e-05 NA NA NA hsa-miR-29b-3p COL4A2 3.10527711861309 3.01242507282711e-32 -0.618750645591112 0.00595258274491188 miRTarBase;MirTarget;miRNATAP -0.162304699728469 9.32896919724563e-06 NA NA NA hsa-miR-29c-3p COL4A2 1.32354490728858 1.84279305179762e-07 -0.618750645591112 0.00595258274491188 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.189027420859138 2.47820806738349e-06 NA NA NA hsa-miR-106a-5p COL4A3 1.3902608059488 6.07931522284525e-05 -2.36887140824932 1.78044268229037e-06 MirTarget;miRNATAP -0.306930821092586 3.00529121387301e-05 NA NA NA hsa-miR-106b-5p COL4A3 1.47447672652218 1.32004094930462e-13 -2.36887140824932 1.78044268229037e-06 MirTarget;miRNATAP -0.666273855541915 2.46498499568936e-09 NA NA NA hsa-miR-107 COL4A3 0.658676029898313 5.11480446318819e-07 -2.36887140824932 1.78044268229037e-06 miRanda -0.476088194339575 0.00714384911382012 NA NA NA hsa-miR-10a-5p COL4A3 0.790595816051606 0.000593731378445468 -2.36887140824932 1.78044268229037e-06 miRNAWalker2_validate -0.367097762091599 0.000235682831652378 NA NA NA hsa-miR-15b-3p COL4A3 0.804736041893915 0.000400279611457186 -2.36887140824932 1.78044268229037e-06 mirMAP -0.555931143935904 1.48720563089866e-07 NA NA NA hsa-miR-17-5p COL4A3 2.07078488653279 2.77403038572568e-19 -2.36887140824932 1.78044268229037e-06 MirTarget;TargetScan;miRNATAP -0.392777485069807 4.21387463330851e-05 NA NA NA hsa-miR-193a-3p COL4A3 0.549173467360291 0.0319030569365466 -2.36887140824932 1.78044268229037e-06 miRanda -0.457353248219602 2.58097270976469e-06 NA NA NA hsa-miR-20b-5p COL4A3 1.35770573270947 0.00260808530013016 -2.36887140824932 1.78044268229037e-06 MirTarget;miRNATAP -0.238011121186923 8.3421674088629e-06 NA NA NA hsa-miR-330-5p COL4A3 0.168520831101569 0.336433937906706 -2.36887140824932 1.78044268229037e-06 miRanda -0.408308862835696 0.0021039097400395 NA NA NA hsa-miR-335-3p COL4A3 1.51116383169018 6.88553098788624e-13 -2.36887140824932 1.78044268229037e-06 mirMAP -0.332580555121215 0.00193636396056421 NA NA NA hsa-miR-3607-3p COL4A3 2.4103172144469 2.69039449048047e-08 -2.36887140824932 1.78044268229037e-06 miRNATAP -0.180672222569988 0.0005479862024542 NA NA NA hsa-miR-370-3p COL4A3 -0.0276376603592858 0.942715150349408 -2.36887140824932 1.78044268229037e-06 MirTarget -0.16928793054131 0.00490729466297457 NA NA NA hsa-miR-410-3p COL4A3 0.0896603881073039 0.811040213315082 -2.36887140824932 1.78044268229037e-06 MirTarget -0.2003531339543 0.00113746244753455 NA NA NA hsa-miR-590-3p COL4A3 0.83851360565783 0.00129224433453587 -2.36887140824932 1.78044268229037e-06 miRanda -0.454393321087509 1.65403497454256e-05 NA NA NA hsa-miR-625-5p COL4A3 1.38208523187596 6.28473801440755e-07 -2.36887140824932 1.78044268229037e-06 MirTarget -0.507650094085233 2.44571538974522e-08 NA NA NA hsa-miR-7-1-3p COL4A3 2.61364240402652 1.98959237815786e-32 -2.36887140824932 1.78044268229037e-06 MirTarget -0.421019990979587 4.11530334746234e-05 NA NA NA hsa-miR-93-3p COL4A3 1.07631808403007 1.63747525692813e-05 -2.36887140824932 1.78044268229037e-06 miRNATAP -0.254058069794726 0.00568529210262919 NA NA NA hsa-miR-93-5p COL4A3 1.50844106515467 1.83836866996875e-12 -2.36887140824932 1.78044268229037e-06 MirTarget;miRNATAP -0.323026102893443 0.00221032821887049 NA NA NA hsa-miR-107 COL4A4 0.658676029898313 5.11480446318819e-07 -1.76080263941118 9.82662874760881e-07 miRanda -0.394323381647096 0.00211083610906191 NA NA NA hsa-miR-130b-3p COL4A4 1.83046548750752 5.04753914574694e-13 -1.76080263941118 9.82662874760881e-07 mirMAP -0.506749810302014 2.03886880878304e-14 NA NA NA hsa-miR-142-3p COL4A4 3.98476449801341 1.56256182021111e-35 -1.76080263941118 9.82662874760881e-07 miRanda -0.211930049926647 1.02917657455135e-05 NA NA NA hsa-miR-15b-3p COL4A4 0.804736041893915 0.000400279611457186 -1.76080263941118 9.82662874760881e-07 MirTarget -0.387217708477986 4.71830062066072e-07 NA NA NA hsa-miR-16-5p COL4A4 0.749619098384047 4.11649450706988e-06 -1.76080263941118 9.82662874760881e-07 mirMAP -0.436798298681975 1.97692083914873e-05 NA NA NA hsa-miR-182-5p COL4A4 3.21839823004635 5.13049145201115e-39 -1.76080263941118 9.82662874760881e-07 MirTarget -0.176894193611787 0.00463959497894204 NA NA NA hsa-miR-576-5p COL4A4 1.02693643167056 1.14846964470173e-06 -1.76080263941118 9.82662874760881e-07 PITA -0.32870749858237 2.76585936124888e-05 NA NA NA hsa-miR-589-3p COL4A4 1.34253876396688 1.84935927493927e-05 -1.76080263941118 9.82662874760881e-07 mirMAP -0.14944789676072 0.00634900663276804 NA NA NA hsa-miR-590-3p COL4A4 0.83851360565783 0.00129224433453587 -1.76080263941118 9.82662874760881e-07 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.40159219427089 1.35084595137987e-07 NA NA NA hsa-miR-629-3p COL4A4 1.31892116211001 0.000114487182853678 -1.76080263941118 9.82662874760881e-07 MirTarget;miRNATAP -0.354150305057471 7.95954961418873e-12 NA NA NA hsa-miR-146b-5p COL4A5 1.0922867893808 5.63754607494775e-06 -1.84548139816355 7.94979725053603e-06 miRanda -0.236274534728735 0.00285935021024136 NA NA NA hsa-miR-29b-3p COL4A5 3.10527711861309 3.01242507282711e-32 -1.84548139816355 7.94979725053603e-06 miRNATAP -0.243221752094046 0.000348551620518813 NA NA NA hsa-miR-590-3p COL4A5 0.83851360565783 0.00129224433453587 -1.84548139816355 7.94979725053603e-06 miRanda;mirMAP -0.278799188858191 0.00156405530123376 NA NA NA hsa-miR-29b-3p COL4A6 3.10527711861309 3.01242507282711e-32 -2.38658098298698 1.85952918581315e-06 miRNATAP -0.356708406229832 1.44706487271509e-05 NA NA NA hsa-miR-590-3p COL4A6 0.83851360565783 0.00129224433453587 -2.38658098298698 1.85952918581315e-06 miRanda -0.477208797006374 7.27430360470175e-06 NA NA NA hsa-miR-96-5p COL4A6 3.0381097138467 4.40362891630201e-24 -2.38658098298698 1.85952918581315e-06 TargetScan -0.462866045486293 3.81079509068736e-08 NA NA NA hsa-miR-335-5p COL6A1 -0.466533891325811 0.0676987038122831 -0.074703065322594 0.768750288988762 miRNAWalker2_validate -0.36456940354175 3.30180883550613e-13 NA NA NA hsa-miR-429 COL6A3 2.3794516574089 1.72813419703734e-13 0.753849546647885 0.0047129103584608 miRNATAP -0.213509526010052 8.19960803625876e-08 NA NA NA hsa-miR-429 COL6A6 2.3794516574089 1.72813419703734e-13 -4.05405717193928 9.5775081978434e-16 miRanda -0.279853969335253 0.000352958977172616 NA NA NA hsa-miR-542-3p COL6A6 1.62226640768239 2.6427102465476e-10 -4.05405717193928 9.5775081978434e-16 miRanda -0.423727486024352 3.40178206396197e-06 NA NA NA hsa-miR-576-5p COL6A6 1.02693643167056 1.14846964470173e-06 -4.05405717193928 9.5775081978434e-16 mirMAP -0.420404091155728 0.000189820563840521 NA NA NA hsa-miR-590-3p COL6A6 0.83851360565783 0.00129224433453587 -4.05405717193928 9.5775081978434e-16 MirTarget;miRanda;mirMAP -0.57040003850229 1.77805540851598e-07 NA NA NA hsa-miR-590-5p COL6A6 2.07441240363458 4.95240551694843e-14 -4.05405717193928 9.5775081978434e-16 miRanda -0.788607325094486 1.55723249004063e-14 NA NA NA hsa-miR-335-5p COL9A2 -0.466533891325811 0.0676987038122831 1.54381720467031 0.000122567583905136 miRNAWalker2_validate -0.269155501133048 0.000983100237577955 NA NA NA hsa-let-7a-5p COL9A3 -1.37014061604018 3.11451492971224e-14 1.42891668381768 0.00061426809573401 TargetScan -0.475835031803748 4.70237230420243e-06 NA NA NA hsa-miR-30d-5p COL9A3 -0.920901858717441 3.50898334321668e-05 1.42891668381768 0.00061426809573401 MirTarget -0.222822230515786 0.00995250818601654 NA NA NA hsa-miR-186-5p CREB1 0.852175445703945 6.88885738584309e-10 -0.10570054283813 0.192620062601134 mirMAP -0.100691412454027 0.000150964862953405 NA NA NA hsa-miR-22-3p CREB1 1.42501909916631 1.72295005910055e-25 -0.10570054283813 0.192620062601134 MirTarget -0.136682552691336 1.04846758574703e-07 NA NA NA hsa-let-7a-5p CREB3L2 -1.37014061604018 3.11451492971224e-14 0.456460806139882 0.00403307619810407 mirMAP -0.133346649158125 0.000757535014534642 NA NA NA hsa-let-7d-5p CREB3L2 -0.618145137285851 6.06067642715858e-05 0.456460806139882 0.00403307619810407 mirMAP -0.161799811836619 0.000671767105137566 NA NA NA hsa-let-7g-5p CREB3L2 0.0837630831079359 0.583083118232597 0.456460806139882 0.00403307619810407 mirMAP -0.152695483536481 0.00165096977198792 NA NA NA hsa-miR-146b-5p CREB3L2 1.0922867893808 5.63754607494775e-06 0.456460806139882 0.00403307619810407 miRanda;mirMAP -0.104567624107958 0.000519190406834959 NA NA NA hsa-miR-16-5p CREB3L2 0.749619098384047 4.11649450706988e-06 0.456460806139882 0.00403307619810407 miRNAWalker2_validate -0.201442667495513 6.42967626985123e-06 NA NA NA hsa-miR-185-5p CREB3L2 1.14291034858482 2.95777119743491e-13 0.456460806139882 0.00403307619810407 MirTarget -0.123273091830602 0.00733288415246565 NA NA NA hsa-miR-186-5p CREB3L2 0.852175445703945 6.88885738584309e-10 0.456460806139882 0.00403307619810407 MirTarget -0.160153612027831 0.00237953424961407 NA NA NA hsa-miR-374a-5p CREB3L2 -0.197027254874826 0.298080902192861 0.456460806139882 0.00403307619810407 mirMAP -0.170683985182811 8.54976896581796e-05 NA NA NA hsa-miR-92a-1-5p CREB3L2 -0.206144909572847 0.487857247338839 0.456460806139882 0.00403307619810407 MirTarget -0.111954992089675 9.35037414790276e-06 NA NA NA hsa-miR-92a-3p CREB3L2 -0.136362762339122 0.493412263619364 0.456460806139882 0.00403307619810407 miRNAWalker2_validate;MirTarget;miRNATAP -0.127632059596134 0.000544612980542748 NA NA NA hsa-miR-141-3p CREB5 3.36993755486106 5.42939251147195e-32 -0.937498808424424 0.00202007836266341 mirMAP -0.260749630793579 7.36913641270227e-09 NA NA NA hsa-miR-17-5p CREB5 2.07078488653279 2.77403038572568e-19 -0.937498808424424 0.00202007836266341 MirTarget;TargetScan;miRNATAP -0.242748039846086 3.10241813486864e-05 NA NA NA hsa-miR-182-5p CREB5 3.21839823004635 5.13049145201115e-39 -0.937498808424424 0.00202007836266341 mirMAP -0.196214597915693 0.000168924911253819 NA NA NA hsa-miR-186-5p CREB5 0.852175445703945 6.88885738584309e-10 -0.937498808424424 0.00202007836266341 mirMAP -0.265371310558821 0.00875330774694166 NA NA NA hsa-miR-200a-3p CREB5 3.14766878548496 1.32850889777422e-21 -0.937498808424424 0.00202007836266341 mirMAP -0.111251011438664 0.00763394002064587 NA NA NA hsa-miR-200c-3p CREB5 0.380533388300368 0.0842181838538353 -0.937498808424424 0.00202007836266341 miRNATAP -0.391425225364452 4.77078877367416e-10 NA NA NA hsa-miR-20a-5p CREB5 2.64649625616975 5.1469418982085e-27 -0.937498808424424 0.00202007836266341 MirTarget;miRNATAP -0.202335003269053 0.000166038754077185 NA NA NA hsa-miR-26b-3p CREB5 1.37388760789373 8.32526977075803e-09 -0.937498808424424 0.00202007836266341 MirTarget -0.164718254605262 0.00454853377047808 NA NA NA hsa-miR-576-5p CREB5 1.02693643167056 1.14846964470173e-06 -0.937498808424424 0.00202007836266341 PITA;mirMAP -0.191878849283091 0.00364575365619369 NA NA NA hsa-miR-7-1-3p CREB5 2.61364240402652 1.98959237815786e-32 -0.937498808424424 0.00202007836266341 mirMAP -0.237124341118485 0.00014743455645735 NA NA NA hsa-miR-106a-5p CSF1 1.3902608059488 6.07931522284525e-05 -0.650264836121052 0.00786919304896235 miRNATAP -0.157656804933477 1.13944120373499e-05 NA NA NA hsa-miR-106b-5p CSF1 1.47447672652218 1.32004094930462e-13 -0.650264836121052 0.00786919304896235 miRNATAP -0.305783120990785 2.32822844592846e-08 NA NA NA hsa-miR-107 CSF1 0.658676029898313 5.11480446318819e-07 -0.650264836121052 0.00786919304896235 miRanda -0.324481705932923 0.00016709638617701 NA NA NA hsa-miR-128-3p CSF1 1.03509868349735 2.11606310588315e-10 -0.650264836121052 0.00786919304896235 MirTarget -0.18867678881791 0.00593057243578252 22909061 By mutations in putative miRNA targets in CSF-1 mRNA 3'UTR we identified a common target for both miR-128 and miR-152; We have also found that both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro two major aspects of the metastatic potential of cancer cells; Our results provide the evidence for a mechanism by which miR-128 and miR-152 down-regulate CSF-1 an important regulator of ovarian cancer motility ovarian cancer hsa-miR-130b-3p CSF1 1.83046548750752 5.04753914574694e-13 -0.650264836121052 0.00786919304896235 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.135196572862612 0.00318019283438574 22005523 CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system; CSF-1 expression was negatively associated with miR-130b level in ovarian tissues and cell lines; Luciferase assay validated CSF-1 is a direct target of miR-130b; Knock-down of CSF-1 sensitized ovarian cancer cells to anticancer drugs and could partially attenuate the resistance inducing effect of miR-130b inhibitors; Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1 and the silencing of miR-130b may be mediated by DNA methylation drug resistance ovarian cancer hsa-miR-148b-3p CSF1 0.483970528590224 0.0026495409465901 -0.650264836121052 0.00786919304896235 miRNAWalker2_validate -0.422070895660298 1.25558305987895e-09 NA NA NA hsa-miR-17-5p CSF1 2.07078488653279 2.77403038572568e-19 -0.650264836121052 0.00786919304896235 TargetScan;miRNATAP -0.306088841322867 3.52700354247209e-11 NA NA NA hsa-miR-20a-5p CSF1 2.64649625616975 5.1469418982085e-27 -0.650264836121052 0.00786919304896235 miRNATAP -0.250272644578681 4.83156805874136e-09 NA NA NA hsa-miR-335-5p CSF1 -0.466533891325811 0.0676987038122831 -0.650264836121052 0.00786919304896235 miRNAWalker2_validate -0.250864209186742 3.20501038060371e-07 NA NA NA hsa-miR-429 CSF1 2.3794516574089 1.72813419703734e-13 -0.650264836121052 0.00786919304896235 PITA;miRanda;miRNATAP -0.185165324027372 4.07583138622974e-07 NA NA NA hsa-miR-93-5p CSF1 1.50844106515467 1.83836866996875e-12 -0.650264836121052 0.00786919304896235 miRNATAP -0.190058749425355 0.00022284034696416 NA NA NA hsa-miR-96-5p CSF1 3.0381097138467 4.40362891630201e-24 -0.650264836121052 0.00786919304896235 miRNATAP -0.149502063926274 0.00027907319742473 NA NA NA hsa-miR-107 CSF1R 0.658676029898313 5.11480446318819e-07 -0.654660428048424 0.0113734786538348 miRanda -0.417277311120845 4.28261039067918e-06 NA NA NA hsa-miR-200a-3p CSF3 3.14766878548496 1.32850889777422e-21 -3.80391444649431 7.58847238583904e-10 miRNATAP -0.245268194082103 0.00442533873575079 NA NA NA hsa-miR-28-5p CSF3 1.19639196514745 4.59365801666536e-18 -3.80391444649431 7.58847238583904e-10 miRanda -0.695441224202475 0.00068192834511052 NA NA NA hsa-miR-542-3p CSF3 1.62226640768239 2.6427102465476e-10 -3.80391444649431 7.58847238583904e-10 miRanda -0.30945371476692 0.00530732373682463 NA NA NA hsa-miR-940 CSF3R 0.011138136211269 0.974925352379525 -1.77217614776242 7.01059226795045e-07 MirTarget -0.138211106157438 0.00891583497939948 NA NA NA hsa-miR-200b-3p DDIT4 1.55157578247391 4.83790020897188e-09 0.609442593082457 0.0294103027780334 TargetScan -0.132037769752402 0.00585924919175337 NA NA NA hsa-miR-30b-5p DDIT4 0.358144314839612 0.138026229059594 0.609442593082457 0.0294103027780334 MirTarget -0.253423928849264 1.8471251894146e-06 NA NA NA hsa-miR-30c-5p DDIT4 -0.327319105755825 0.123595832152687 0.609442593082457 0.0294103027780334 MirTarget;miRNATAP -0.174806583437269 0.00411913749737013 NA NA NA hsa-miR-30d-5p DDIT4 -0.920901858717441 3.50898334321668e-05 0.609442593082457 0.0294103027780334 MirTarget;miRNATAP -0.316533147993562 2.81465814845051e-08 NA NA NA hsa-miR-32-5p DDIT4 0.876853679269853 6.04859399018691e-05 0.609442593082457 0.0294103027780334 miRNATAP -0.2376127213456 0.000188969310362304 NA NA NA hsa-miR-92b-3p DDIT4 0.0478787637665503 0.831716894621477 0.609442593082457 0.0294103027780334 miRNATAP -0.176763468290616 0.00209915470212765 NA NA NA hsa-miR-218-5p EFNA1 -0.281408491748349 0.259553612322657 0.12611339673549 0.589690874025389 miRNAWalker2_validate -0.134029632827446 0.00247753786964095 NA NA NA hsa-miR-145-5p EFNA3 -1.34926078156437 2.63526538800669e-07 2.39841241673629 3.59658741816566e-20 miRNATAP -0.165896963340704 0.000435838250613543 NA NA NA hsa-miR-2110 EFNA3 -1.92124860612475 1.1464887721828e-12 2.39841241673629 3.59658741816566e-20 miRNATAP -0.149738081373567 0.00103641065869651 NA NA NA hsa-miR-221-5p EFNA3 -2.2173523967387 1.8954728277084e-09 2.39841241673629 3.59658741816566e-20 MirTarget -0.136736000341119 6.57070309154595e-05 NA NA NA hsa-miR-30a-5p EFNA3 -0.924084264430689 0.000762030454634728 2.39841241673629 3.59658741816566e-20 MirTarget;mirMAP;miRNATAP -0.323550479482298 3.19474292067047e-13 NA NA NA hsa-miR-30d-5p EFNA3 -0.920901858717441 3.50898334321668e-05 2.39841241673629 3.59658741816566e-20 MirTarget;mirMAP;miRNATAP -0.253322025389199 5.38120112437305e-06 NA NA NA hsa-miR-361-3p EFNA3 0.0988926195529967 0.549128728500555 2.39841241673629 3.59658741816566e-20 MirTarget;miRNATAP -0.210520640756772 0.00608274546614107 NA NA NA hsa-miR-423-5p EFNA3 -1.80309342242719 1.34791344187441e-19 2.39841241673629 3.59658741816566e-20 MirTarget;PITA;miRNATAP -0.300571019130052 5.7416909159278e-07 NA NA NA hsa-miR-486-5p EFNA3 -4.38592782786845 2.75864166493846e-29 2.39841241673629 3.59658741816566e-20 miRanda -0.234228131759917 9.92695316343125e-16 NA NA NA hsa-miR-140-5p EFNA5 0.669142684153918 0.000335928403032308 0.766518652762425 0.00961848889418976 miRanda -0.204976237889406 0.00644928467018422 NA NA NA hsa-miR-150-5p EFNA5 -0.702328520623782 0.0215316651134431 0.766518652762425 0.00961848889418976 mirMAP;miRNATAP -0.118543563825026 0.00796270809631905 NA NA NA hsa-miR-15b-3p EFNA5 0.804736041893915 0.000400279611457186 0.766518652762425 0.00961848889418976 mirMAP -0.170641264441551 0.00700258649546722 NA NA NA hsa-miR-217 EFNA5 1.88358668330143 3.93795605235061e-07 0.766518652762425 0.00961848889418976 MirTarget;miRanda -0.117368715311579 0.00286681436397859 NA NA NA hsa-miR-335-3p EFNA5 1.51116383169018 6.88553098788624e-13 0.766518652762425 0.00961848889418976 mirMAP -0.185236590240764 0.00353795450372532 NA NA NA hsa-miR-335-5p EFNA5 -0.466533891325811 0.0676987038122831 0.766518652762425 0.00961848889418976 miRNAWalker2_validate -0.222326751872231 0.000200234786447207 NA NA NA hsa-miR-342-3p EFNA5 -0.128691966564961 0.561034080130801 0.766518652762425 0.00961848889418976 miRNATAP -0.171626597394371 0.00564714427078974 NA NA NA hsa-miR-362-3p EFNA5 0.194097672030785 0.52808475179225 0.766518652762425 0.00961848889418976 miRanda -0.151234117297808 0.00657303041936921 NA NA NA hsa-miR-378a-3p EFNA5 -2.0140903990983 1.146745431034e-18 0.766518652762425 0.00961848889418976 miRNATAP -0.175477598420107 0.00232847823669233 NA NA NA hsa-miR-421 EFNA5 0.170525317701774 0.535277026680289 0.766518652762425 0.00961848889418976 mirMAP -0.211368335666247 8.74421427145838e-05 NA NA NA hsa-miR-501-5p EFNA5 0.411357595674671 0.10435288464149 0.766518652762425 0.00961848889418976 mirMAP -0.169021809608922 0.00174145021645448 NA NA NA hsa-miR-141-3p EGFR 3.36993755486106 5.42939251147195e-32 -0.271157231776117 0.423394925561077 MirTarget -0.182043268046231 0.000322561477910029 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-142-3p EGFR 3.98476449801341 1.56256182021111e-35 -0.271157231776117 0.423394925561077 miRanda -0.13728647251485 0.00224315827652832 NA NA NA hsa-miR-148b-5p EGFR 1.39335695292409 2.13220380550073e-07 -0.271157231776117 0.423394925561077 mirMAP -0.312208825866794 5.03093953543843e-06 NA NA NA hsa-miR-17-5p EGFR 2.07078488653279 2.77403038572568e-19 -0.271157231776117 0.423394925561077 TargetScan -0.227660150278677 0.000449250209613956 NA NA NA hsa-miR-192-5p EGFR 2.03412119423736 1.6357945826287e-05 -0.271157231776117 0.423394925561077 mirMAP -0.148537455733138 4.68324614985853e-06 NA NA NA hsa-miR-19b-1-5p EGFR 1.71217036351784 3.28561659177495e-12 -0.271157231776117 0.423394925561077 MirTarget;mirMAP -0.196763487131799 0.00607880458029935 NA NA NA hsa-miR-200a-3p EGFR 3.14766878548496 1.32850889777422e-21 -0.271157231776117 0.423394925561077 MirTarget -0.135522178803702 0.00339714885174827 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-320b EGFR 0.226640952564488 0.378818692487242 -0.271157231776117 0.423394925561077 miRanda;mirMAP -0.169207384217798 0.00529161513582327 NA NA NA hsa-miR-335-5p EGFR -0.466533891325811 0.0676987038122831 -0.271157231776117 0.423394925561077 miRNAWalker2_validate -0.183988914461652 0.00717835650953039 NA NA NA hsa-miR-375 EGFR 0.615547997686534 0.149199273675144 -0.271157231776117 0.423394925561077 miRanda -0.181944225035217 4.73664955454239e-07 NA NA NA hsa-miR-103a-3p EIF4B 0.538497806383155 1.88134691850591e-05 -0.221574072071826 0.0707566183691306 MirTarget;miRNATAP -0.128801163927682 0.00435534261148103 NA NA NA hsa-miR-149-5p EIF4B -0.185943525121015 0.638713382556459 -0.221574072071826 0.0707566183691306 miRNAWalker2_validate;miRNATAP -0.100028705166955 5.70531722662773e-13 NA NA NA hsa-miR-15a-5p EIF4B 1.62575353599172 1.55312121019827e-19 -0.221574072071826 0.0707566183691306 miRNATAP -0.14029195221406 2.92115496234136e-06 NA NA NA hsa-miR-185-5p EIF4B 1.14291034858482 2.95777119743491e-13 -0.221574072071826 0.0707566183691306 MirTarget -0.155606517815325 9.39735635364883e-06 NA NA NA hsa-miR-193a-3p EIF4B 0.549173467360291 0.0319030569365466 -0.221574072071826 0.0707566183691306 miRanda -0.120575433874547 3.45124934422834e-07 NA NA NA hsa-miR-339-5p EIF4B 0.536997313601114 0.0488090394176611 -0.221574072071826 0.0707566183691306 miRanda -0.141142891711417 2.89072252600077e-12 NA NA NA hsa-miR-342-3p EIF4B -0.128691966564961 0.561034080130801 -0.221574072071826 0.0707566183691306 miRanda -0.160390481197487 1.65242391839946e-10 NA NA NA hsa-miR-423-3p EIF4B 0.237880985943445 0.221744070846278 -0.221574072071826 0.0707566183691306 miRNAWalker2_validate -0.137900850810487 1.76527684792325e-06 NA NA NA hsa-miR-139-5p EIF4E -2.26625553116965 7.22375119369519e-16 0.139971135571262 0.21378211756024 miRanda -0.105305471908209 1.82604906028467e-09 NA NA NA hsa-miR-145-5p EIF4E -1.34926078156437 2.63526538800669e-07 0.139971135571262 0.21378211756024 miRNAWalker2_validate;miRTarBase -0.118124217842371 6.90276986338154e-10 NA NA NA hsa-miR-195-3p EIF4E -1.33068822339418 6.65427393047357e-09 0.139971135571262 0.21378211756024 mirMAP -0.133161051232494 1.22059953709548e-09 NA NA NA hsa-miR-30b-5p EIF4E 0.358144314839612 0.138026229059594 0.139971135571262 0.21378211756024 mirMAP -0.121203139100493 9.7504708381074e-09 NA NA NA hsa-miR-30c-5p EIF4E -0.327319105755825 0.123595832152687 0.139971135571262 0.21378211756024 mirMAP -0.209994080917116 3.50641549814748e-19 NA NA NA hsa-miR-30d-3p EIF4E 0.00396376345349925 0.986457040013182 0.139971135571262 0.21378211756024 mirMAP -0.10809245113846 1.22707687519464e-05 NA NA NA hsa-miR-320a EIF4E -0.961144925954715 1.62478794429204e-08 0.139971135571262 0.21378211756024 MirTarget;miRanda -0.137912541912181 3.91843747814961e-06 NA NA NA hsa-miR-500a-5p EIF4E 0.648155655714409 0.0104657432932038 0.139971135571262 0.21378211756024 mirMAP -0.10079306749408 1.19064139391264e-06 NA NA NA hsa-miR-125a-5p EIF4EBP1 -1.04824536696301 3.97386082850476e-07 1.23820184181367 2.37941726971645e-06 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.263609655673837 5.92442887758411e-06 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ovarian cancer hsa-miR-146b-3p EIF4EBP1 -0.808296168180355 0.000870284326590347 1.23820184181367 2.37941726971645e-06 miRNATAP -0.138363451576497 0.0058330130369118 NA NA NA hsa-miR-940 EPHA2 0.011138136211269 0.974925352379525 -0.364933990274224 0.225946505222038 miRNAWalker2_validate -0.117179593758916 0.00777902546926027 NA NA NA hsa-miR-127-3p EPOR -0.723429813065737 0.0192747925933947 -0.145534212833245 0.465074577214786 miRanda -0.135114313646344 4.18955941435971e-06 NA NA NA hsa-miR-330-3p EPOR -0.716924999893351 0.000796236278616087 -0.145534212833245 0.465074577214786 mirMAP -0.149653706086766 0.000458105748043046 NA NA NA hsa-miR-16-2-3p F2R 0.503964803530872 0.0263648405197492 -0.76095368914221 0.000261026503332859 mirMAP -0.203101603761528 9.89406352380112e-06 NA NA NA hsa-miR-20a-3p F2R 2.51803599558247 4.92479325298629e-13 -0.76095368914221 0.000261026503332859 MirTarget -0.117754238644107 0.000716119301521351 NA NA NA hsa-miR-29a-5p F2R 1.89519956688438 1.03453349363915e-11 -0.76095368914221 0.000261026503332859 MirTarget -0.256073279465951 1.25267201219116e-10 NA NA NA hsa-miR-335-3p F2R 1.51116383169018 6.88553098788624e-13 -0.76095368914221 0.000261026503332859 MirTarget -0.11616601830495 0.0096401786437409 NA NA NA hsa-miR-429 F2R 2.3794516574089 1.72813419703734e-13 -0.76095368914221 0.000261026503332859 miRanda -0.207010407684708 2.13257508721853e-11 NA NA NA hsa-miR-589-3p F2R 1.34253876396688 1.84935927493927e-05 -0.76095368914221 0.000261026503332859 MirTarget -0.107772034781625 0.000609479593507269 NA NA NA hsa-miR-590-5p F2R 2.07441240363458 4.95240551694843e-14 -0.76095368914221 0.000261026503332859 miRanda -0.180537192048582 1.8016286963804e-05 NA NA NA hsa-miR-664a-3p F2R 0.443077463053857 0.0214248925850984 -0.76095368914221 0.000261026503332859 mirMAP -0.281737035466527 1.3914673669426e-08 NA NA NA hsa-let-7e-5p FASLG -0.749418249305995 7.34668338492227e-05 0.227219484524508 0.525243087995098 miRNATAP -0.243056494896728 0.00520293662614488 NA NA NA hsa-miR-16-1-3p FGF1 1.50034693398929 6.63958242991125e-10 -0.577676136313124 0.0506048044371249 mirMAP -0.264990724395016 0.000104336880288483 NA NA NA hsa-miR-186-5p FGF1 0.852175445703945 6.88885738584309e-10 -0.577676136313124 0.0506048044371249 mirMAP -0.468236590634635 1.51395461317672e-06 NA NA NA hsa-miR-18a-5p FGF1 1.37435209536521 9.2173853686829e-06 -0.577676136313124 0.0506048044371249 MirTarget -0.313741396264592 1.24482978490312e-11 NA NA NA hsa-miR-320b FGF1 0.226640952564488 0.378818692487242 -0.577676136313124 0.0506048044371249 miRanda -0.145122007313635 0.00620299731128628 NA NA NA hsa-miR-330-5p FGF1 0.168520831101569 0.336433937906706 -0.577676136313124 0.0506048044371249 miRanda;miRNATAP -0.396337147508732 3.26538084155222e-07 NA NA NA hsa-miR-429 FGF1 2.3794516574089 1.72813419703734e-13 -0.577676136313124 0.0506048044371249 miRNATAP -0.116223459446297 0.00906049231323183 NA NA NA hsa-miR-576-5p FGF1 1.02693643167056 1.14846964470173e-06 -0.577676136313124 0.0506048044371249 PITA;mirMAP -0.353451864713746 2.30476528411685e-08 NA NA NA hsa-miR-590-5p FGF1 2.07441240363458 4.95240551694843e-14 -0.577676136313124 0.0506048044371249 MirTarget;miRanda;miRNATAP -0.188750550916759 0.00157081419432906 NA NA NA hsa-miR-629-5p FGF1 1.31657090341737 1.45711558652127e-12 -0.577676136313124 0.0506048044371249 MirTarget -0.255543406785593 0.000362449168272974 NA NA NA hsa-miR-7-5p FGF1 0.343825848926135 0.435063427976906 -0.577676136313124 0.0506048044371249 miRNAWalker2_validate -0.167943341210869 1.20539892015732e-05 NA NA NA hsa-let-7a-5p FGF11 -1.37014061604018 3.11451492971224e-14 3.58238481677861 7.07821884742881e-23 TargetScan;mirMAP;miRNATAP -0.568985035003898 1.41653445623786e-09 NA NA NA hsa-let-7b-5p FGF11 -1.62016148171663 1.56547487335694e-15 3.58238481677861 7.07821884742881e-23 mirMAP;miRNATAP -0.480829455651022 7.33790550378727e-09 NA NA NA hsa-let-7d-5p FGF11 -0.618145137285851 6.06067642715858e-05 3.58238481677861 7.07821884742881e-23 mirMAP;miRNATAP -0.403117661585255 0.000426361486333792 NA NA NA hsa-miR-125a-5p FGF11 -1.04824536696301 3.97386082850476e-07 3.58238481677861 7.07821884742881e-23 mirMAP -0.283106012258554 0.000790298136640464 NA NA NA hsa-miR-195-5p FGF11 -1.01577502605386 4.80814718341729e-05 3.58238481677861 7.07821884742881e-23 mirMAP -0.276250424568979 0.000176750217569729 NA NA NA hsa-miR-221-5p FGF11 -2.2173523967387 1.8954728277084e-09 3.58238481677861 7.07821884742881e-23 miRNATAP -0.140867639708279 0.00355614353073565 NA NA NA hsa-miR-320a FGF11 -0.961144925954715 1.62478794429204e-08 3.58238481677861 7.07821884742881e-23 miRanda -0.314554800922091 0.00217972507442822 NA NA NA hsa-miR-335-5p FGF11 -0.466533891325811 0.0676987038122831 3.58238481677861 7.07821884742881e-23 miRNAWalker2_validate;mirMAP -0.256647530759583 0.000881158505615166 NA NA NA hsa-let-7b-3p FGF12 -1.81889978084306 6.9913416210266e-19 -0.540341291347842 0.2437250465075 MirTarget -0.28093879604846 0.0051773171700438 NA NA NA hsa-miR-200b-3p FGF12 1.55157578247391 4.83790020897188e-09 -0.540341291347842 0.2437250465075 TargetScan -0.237021249202824 0.00277049015484138 NA NA NA hsa-miR-29a-5p FGF12 1.89519956688438 1.03453349363915e-11 -0.540341291347842 0.2437250465075 MirTarget -0.276278524444419 0.00204171562114313 NA NA NA hsa-miR-3065-5p FGF12 0.653308707552535 0.0999497219778851 -0.540341291347842 0.2437250465075 mirMAP -0.219717935817458 0.000160441200217862 NA NA NA hsa-miR-429 FGF12 2.3794516574089 1.72813419703734e-13 -0.540341291347842 0.2437250465075 miRNATAP -0.210520637292102 0.0025270091646609 NA NA NA hsa-miR-455-5p FGF12 1.36946341828134 5.05118627562807e-08 -0.540341291347842 0.2437250465075 miRanda -0.291759936628716 0.0026130555582076 NA NA NA hsa-miR-511-5p FGF12 -0.299232651841262 0.292871281649728 -0.540341291347842 0.2437250465075 MirTarget -0.342048393598124 4.53535066794083e-06 NA NA NA hsa-miR-141-3p FGF13 3.36993755486106 5.42939251147195e-32 0.0874395647550581 0.810556248943047 TargetScan -0.199819863219093 0.000244921517068874 NA NA NA hsa-miR-338-5p FGF13 -1.83316380675941 4.03269924759167e-07 0.0874395647550581 0.810556248943047 PITA -0.175986648309995 0.000113756652771771 NA NA NA hsa-miR-421 FGF14 0.170525317701774 0.535277026680289 -1.420755529251 1.88430020060794e-06 miRanda -0.341718556233856 2.50791289827731e-10 NA NA NA hsa-miR-590-3p FGF14 0.83851360565783 0.00129224433453587 -1.420755529251 1.88430020060794e-06 miRanda -0.434093352571676 3.47983378758532e-12 NA NA NA hsa-miR-96-5p FGF14 3.0381097138467 4.40362891630201e-24 -1.420755529251 1.88430020060794e-06 TargetScan -0.342893565188291 4.97164511915916e-12 NA NA NA hsa-miR-21-5p FGF18 4.38165933891779 1.52536633902505e-92 -2.01878202132787 1.47991026443687e-06 miRNATAP -0.445995016466712 1.11879820670501e-09 NA NA NA hsa-miR-424-5p FGF18 1.26485330287919 6.1498991028257e-06 -2.01878202132787 1.47991026443687e-06 miRNATAP -0.208512227284213 0.00257215272427139 NA NA NA hsa-miR-590-5p FGF18 2.07441240363458 4.95240551694843e-14 -2.01878202132787 1.47991026443687e-06 miRanda;miRNATAP -0.29033796179898 0.000691235501435991 NA NA NA hsa-miR-9-5p FGF18 4.99250901331516 2.59132733422801e-19 -2.01878202132787 1.47991026443687e-06 miRNATAP -0.161460646965575 1.31749803347013e-06 NA NA NA hsa-miR-142-3p FGF2 3.98476449801341 1.56256182021111e-35 -2.54526710952658 2.81433930536102e-18 miRanda -0.108425653539561 0.00717069701654876 NA NA NA hsa-miR-15a-5p FGF2 1.62575353599172 1.55312121019827e-19 -2.54526710952658 2.81433930536102e-18 MirTarget;miRNATAP -0.36038112870066 1.28425682158144e-06 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 1.50034693398929 6.63958242991125e-10 -2.54526710952658 2.81433930536102e-18 mirMAP -0.257821575620002 0.000236815470978822 NA NA NA hsa-miR-181b-5p FGF2 0.668793269169928 0.000239998092406404 -2.54526710952658 2.81433930536102e-18 mirMAP -0.262170032088161 0.000626951093969658 NA NA NA hsa-miR-186-5p FGF2 0.852175445703945 6.88885738584309e-10 -2.54526710952658 2.81433930536102e-18 miRNAWalker2_validate;mirMAP -0.312620722879404 0.00189105104228049 NA NA NA hsa-miR-19b-1-5p FGF2 1.71217036351784 3.28561659177495e-12 -2.54526710952658 2.81433930536102e-18 mirMAP -0.32669324350081 2.87433739267694e-07 NA NA NA hsa-miR-200b-3p FGF2 1.55157578247391 4.83790020897188e-09 -2.54526710952658 2.81433930536102e-18 mirMAP -0.237329951619637 4.11083003299206e-06 NA NA NA hsa-miR-200c-3p FGF2 0.380533388300368 0.0842181838538353 -2.54526710952658 2.81433930536102e-18 mirMAP -0.303839594432928 1.47159143745806e-06 NA NA NA hsa-miR-20a-3p FGF2 2.51803599558247 4.92479325298629e-13 -2.54526710952658 2.81433930536102e-18 mirMAP -0.234318235832673 2.96971224443726e-06 NA NA NA hsa-miR-21-3p FGF2 2.54206008030157 1.11598785398763e-30 -2.54526710952658 2.81433930536102e-18 mirMAP -0.372000947223037 1.77917903992197e-10 NA NA NA hsa-miR-21-5p FGF2 4.38165933891779 1.52536633902505e-92 -2.54526710952658 2.81433930536102e-18 mirMAP -0.439558209079983 1.20994163416464e-17 NA NA NA hsa-miR-29a-5p FGF2 1.89519956688438 1.03453349363915e-11 -2.54526710952658 2.81433930536102e-18 mirMAP -0.365049356850144 2.5272073429353e-10 NA NA NA hsa-miR-32-5p FGF2 0.876853679269853 6.04859399018691e-05 -2.54526710952658 2.81433930536102e-18 miRNAWalker2_validate -0.179124683112376 0.00965081572899845 NA NA NA hsa-miR-335-3p FGF2 1.51116383169018 6.88553098788624e-13 -2.54526710952658 2.81433930536102e-18 mirMAP -0.374424532101383 5.108451362917e-09 NA NA NA hsa-miR-429 FGF2 2.3794516574089 1.72813419703734e-13 -2.54526710952658 2.81433930536102e-18 mirMAP -0.274666460864277 1.00411224771278e-09 NA NA NA hsa-miR-450b-5p FGF2 1.69248953402469 1.96052058003353e-07 -2.54526710952658 2.81433930536102e-18 mirMAP -0.165505837504251 0.000468241696245016 NA NA NA hsa-miR-503-5p FGF2 1.97129438815516 2.1704434283035e-09 -2.54526710952658 2.81433930536102e-18 miRNAWalker2_validate -0.205012336037686 7.26622582895517e-07 NA NA NA hsa-miR-589-3p FGF2 1.34253876396688 1.84935927493927e-05 -2.54526710952658 2.81433930536102e-18 mirMAP -0.178139639483111 8.93094177354748e-05 NA NA NA hsa-miR-590-5p FGF2 2.07441240363458 4.95240551694843e-14 -2.54526710952658 2.81433930536102e-18 miRanda;mirMAP -0.34395539570476 1.33985562743507e-08 NA NA NA hsa-miR-93-3p FGF2 1.07631808403007 1.63747525692813e-05 -2.54526710952658 2.81433930536102e-18 mirMAP -0.263196364039628 1.81238194047644e-06 NA NA NA hsa-miR-3065-5p FGF5 0.653308707552535 0.0999497219778851 1.41965936869673 0.00663601545902237 mirMAP -0.30851318309695 2.58273355476571e-06 NA NA NA hsa-miR-30a-5p FGF5 -0.924084264430689 0.000762030454634728 1.41965936869673 0.00663601545902237 mirMAP -0.458682122515636 1.23681430790792e-07 NA NA NA hsa-miR-30b-5p FGF5 0.358144314839612 0.138026229059594 1.41965936869673 0.00663601545902237 mirMAP -0.539045077966163 5.42071635746139e-08 NA NA NA hsa-miR-30c-5p FGF5 -0.327319105755825 0.123595832152687 1.41965936869673 0.00663601545902237 mirMAP -0.720160664714379 1.3358272407005e-10 NA NA NA hsa-miR-30d-5p FGF5 -0.920901858717441 3.50898334321668e-05 1.41965936869673 0.00663601545902237 mirMAP -0.922796453852226 7.74508150171104e-19 NA NA NA hsa-miR-30e-5p FGF5 1.60414100786743 3.78951090573667e-19 1.41965936869673 0.00663601545902237 mirMAP -0.42672903139199 0.00102753035462209 NA NA NA hsa-miR-338-3p FGF5 0.726843067232002 0.0506251324215494 1.41965936869673 0.00663601545902237 miRanda -0.249982640438075 0.000108939596018716 NA NA NA hsa-miR-486-5p FGF5 -4.38592782786845 2.75864166493846e-29 1.41965936869673 0.00663601545902237 miRanda -0.172915883890662 0.0028302765942552 NA NA NA hsa-miR-500a-5p FGF5 0.648155655714409 0.0104657432932038 1.41965936869673 0.00663601545902237 mirMAP -0.391631377809049 5.96983250124773e-05 NA NA NA hsa-miR-501-5p FGF5 0.411357595674671 0.10435288464149 1.41965936869673 0.00663601545902237 PITA;mirMAP -0.425344723856289 7.43244452614636e-06 NA NA NA hsa-miR-107 FGF7 0.658676029898313 5.11480446318819e-07 -1.35096332880614 7.44222727225117e-07 PITA;miRanda;miRNATAP -0.384064720888837 7.51486049064498e-05 NA NA NA hsa-miR-15a-5p FGF7 1.62575353599172 1.55312121019827e-19 -1.35096332880614 7.44222727225117e-07 miRTarBase;miRNATAP -0.466793239192838 2.83453139790815e-12 NA NA NA hsa-miR-15b-5p FGF7 -1.25935038177398 1.83460220856901e-12 -1.35096332880614 7.44222727225117e-07 miRNATAP -0.195108702684649 0.00524641292904446 NA NA NA hsa-miR-16-1-3p FGF7 1.50034693398929 6.63958242991125e-10 -1.35096332880614 7.44222727225117e-07 mirMAP -0.415291526592944 3.77942867633909e-11 NA NA NA hsa-miR-16-2-3p FGF7 0.503964803530872 0.0263648405197492 -1.35096332880614 7.44222727225117e-07 mirMAP -0.32685238601193 5.84459614417273e-08 NA NA NA hsa-miR-16-5p FGF7 0.749619098384047 4.11649450706988e-06 -1.35096332880614 7.44222727225117e-07 miRNATAP -0.360407939054601 3.33302283380507e-06 NA NA NA hsa-miR-20a-5p FGF7 2.64649625616975 5.1469418982085e-27 -1.35096332880614 7.44222727225117e-07 miRNAWalker2_validate -0.394356736375477 7.25466480479139e-17 NA NA NA hsa-miR-421 FGF7 0.170525317701774 0.535277026680289 -1.35096332880614 7.44222727225117e-07 miRanda -0.163761788143437 0.00112347767405943 NA NA NA hsa-miR-429 FGF7 2.3794516574089 1.72813419703734e-13 -1.35096332880614 7.44222727225117e-07 miRNATAP -0.236095541262009 8.5203274937411e-09 NA NA NA hsa-miR-501-5p FGF7 0.411357595674671 0.10435288464149 -1.35096332880614 7.44222727225117e-07 PITA;mirMAP -0.240038572692252 1.49297440376449e-06 NA NA NA hsa-miR-590-3p FGF7 0.83851360565783 0.00129224433453587 -1.35096332880614 7.44222727225117e-07 PITA;miRanda;mirMAP;miRNATAP -0.153768635331909 0.00851407916887242 NA NA NA hsa-miR-590-5p FGF7 2.07441240363458 4.95240551694843e-14 -1.35096332880614 7.44222727225117e-07 PITA;miRanda -0.342399846177336 4.47018629152173e-10 NA NA NA hsa-miR-7-1-3p FGF7 2.61364240402652 1.98959237815786e-32 -1.35096332880614 7.44222727225117e-07 mirMAP -0.317243751289801 1.53104453627605e-08 NA NA NA hsa-miR-142-3p FGF9 3.98476449801341 1.56256182021111e-35 -1.33489997634345 0.0119359510527769 miRanda -0.297024649065488 2.41524362922675e-05 NA NA NA hsa-miR-142-5p FGF9 1.29672439149353 4.0768822158894e-06 -1.33489997634345 0.0119359510527769 mirMAP -0.338742204386594 0.000287338979970239 NA NA NA hsa-miR-16-2-3p FGF9 0.503964803530872 0.0263648405197492 -1.33489997634345 0.0119359510527769 mirMAP -0.43168768681555 0.000229313476417954 NA NA NA hsa-miR-16-5p FGF9 0.749619098384047 4.11649450706988e-06 -1.33489997634345 0.0119359510527769 miRNATAP -0.466038608257105 0.00194558955642264 NA NA NA hsa-miR-212-3p FGF9 0.404496907089793 0.103551762277891 -1.33489997634345 0.0119359510527769 mirMAP -0.264431225714465 0.00749196276633432 NA NA NA hsa-miR-424-5p FGF9 1.26485330287919 6.1498991028257e-06 -1.33489997634345 0.0119359510527769 miRNATAP -0.299762934200373 0.000543050338372439 NA NA NA hsa-miR-450b-5p FGF9 1.69248953402469 1.96052058003353e-07 -1.33489997634345 0.0119359510527769 mirMAP;miRNATAP -0.215374190152256 0.00967241936107216 NA NA NA hsa-miR-590-3p FGF9 0.83851360565783 0.00129224433453587 -1.33489997634345 0.0119359510527769 miRanda;mirMAP -0.548375938999422 9.0306963195563e-07 NA NA NA hsa-miR-590-5p FGF9 2.07441240363458 4.95240551694843e-14 -1.33489997634345 0.0119359510527769 miRanda -0.525972441590085 8.17616961503178e-07 NA NA NA hsa-miR-9-5p FGF9 4.99250901331516 2.59132733422801e-19 -1.33489997634345 0.0119359510527769 miRNATAP -0.15314002899298 0.000277214145018446 NA NA NA hsa-miR-135b-5p FGFR1 3.25019233805845 1.95560099639034e-15 -0.915442355826397 0.000285266909471616 mirMAP -0.141958622178533 1.77794898106879e-06 NA NA NA hsa-miR-15a-5p FGFR1 1.62575353599172 1.55312121019827e-19 -0.915442355826397 0.000285266909471616 miRNATAP -0.243009183557465 0.000100813439112054 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 0.749619098384047 4.11649450706988e-06 -0.915442355826397 0.000285266909471616 miRTarBase;miRNATAP -0.246942745271025 0.000561455743835118 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 2.07078488653279 2.77403038572568e-19 -0.915442355826397 0.000285266909471616 mirMAP -0.159812129963503 0.00102342937863635 NA NA NA hsa-miR-181b-5p FGFR1 0.668793269169928 0.000239998092406404 -0.915442355826397 0.000285266909471616 miRNAWalker2_validate -0.349477340528312 3.64168342971559e-08 NA NA NA hsa-miR-200a-5p FGFR1 2.26680634475411 1.52168554660094e-17 -0.915442355826397 0.000285266909471616 mirMAP -0.200300874512705 1.91408016005907e-06 NA NA NA hsa-miR-200b-5p FGFR1 0.5652412449293 0.0273948420835934 -0.915442355826397 0.000285266909471616 mirMAP -0.138058985825778 0.00247827404178829 NA NA NA hsa-miR-20a-5p FGFR1 2.64649625616975 5.1469418982085e-27 -0.915442355826397 0.000285266909471616 mirMAP -0.173284530375537 0.000105694699814125 NA NA NA hsa-miR-335-3p FGFR1 1.51116383169018 6.88553098788624e-13 -0.915442355826397 0.000285266909471616 mirMAP -0.240186682957272 8.57963673654244e-06 NA NA NA hsa-miR-146b-5p FGFR2 1.0922867893808 5.63754607494775e-06 -2.39472329620768 3.80959748314848e-11 miRanda -0.184601550928346 0.00873114443578221 NA NA NA hsa-miR-19b-1-5p FGFR2 1.71217036351784 3.28561659177495e-12 -2.39472329620768 3.80959748314848e-11 miRNAWalker2_validate;miRTarBase -0.268412662161793 0.000607501041413817 NA NA NA hsa-miR-542-3p FGFR2 1.62226640768239 2.6427102465476e-10 -2.39472329620768 3.80959748314848e-11 miRanda -0.190402208837821 0.00349409803579517 NA NA NA hsa-miR-590-3p FGFR2 0.83851360565783 0.00129224433453587 -2.39472329620768 3.80959748314848e-11 miRanda -0.383675956139752 7.77181884190165e-07 NA NA NA hsa-miR-142-3p FGFR3 3.98476449801341 1.56256182021111e-35 -1.12699077326621 0.0142487904494546 miRanda -0.224351946350102 0.000237439121756567 NA NA NA hsa-miR-106b-5p FLT1 1.47447672652218 1.32004094930462e-13 -0.853716821222124 3.80935455614656e-05 MirTarget;miRNATAP -0.15196065631928 0.00125967239975962 NA NA NA hsa-miR-142-3p FLT1 3.98476449801341 1.56256182021111e-35 -0.853716821222124 3.80935455614656e-05 miRanda;miRNATAP -0.112934202558696 4.26649818225612e-05 NA NA NA hsa-miR-146b-5p FLT1 1.0922867893808 5.63754607494775e-06 -0.853716821222124 3.80935455614656e-05 miRanda -0.132297507944522 0.000831653018892319 NA NA NA hsa-miR-155-5p FLT1 0.813513839059142 0.000608282725633232 -0.853716821222124 3.80935455614656e-05 miRNAWalker2_validate;mirMAP -0.128527734958511 0.00144749151618481 NA NA NA hsa-miR-17-5p FLT1 2.07078488653279 2.77403038572568e-19 -0.853716821222124 3.80935455614656e-05 MirTarget;TargetScan;miRNATAP -0.135735585570969 0.000695574954147908 NA NA NA hsa-miR-181a-5p FLT1 -0.375429731222937 0.0562142867129802 -0.853716821222124 3.80935455614656e-05 miRNATAP -0.13719850761158 0.00522108723394579 NA NA NA hsa-miR-181b-5p FLT1 0.668793269169928 0.000239998092406404 -0.853716821222124 3.80935455614656e-05 miRNATAP -0.228091988878886 1.41100029468761e-05 NA NA NA hsa-miR-186-5p FLT1 0.852175445703945 6.88885738584309e-10 -0.853716821222124 3.80935455614656e-05 mirMAP -0.319611792696536 3.3593313940787e-06 NA NA NA hsa-miR-19b-3p FLT1 2.10868505662119 5.40846613768389e-17 -0.853716821222124 3.80935455614656e-05 MirTarget -0.129753240316954 0.000840150021747134 NA NA NA hsa-miR-200b-3p FLT1 1.55157578247391 4.83790020897188e-09 -0.853716821222124 3.80935455614656e-05 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.149137497361126 2.67044497229278e-05 21115742 Forced miR-200 expression suppressed Flt1 levels in metastasis-prone lung adenocarcinoma cells derived from K-ras/p53-mutant mice and negatively regulated the Flt1 3'-UTR in reporter assays; We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1 metastasis;tumorigenesis lung cancer hsa-miR-20a-5p FLT1 2.64649625616975 5.1469418982085e-27 -0.853716821222124 3.80935455614656e-05 MirTarget;miRNATAP -0.145399235210941 7.64688683215748e-05 NA NA NA hsa-miR-28-5p FLT1 1.19639196514745 4.59365801666536e-18 -0.853716821222124 3.80935455614656e-05 miRanda -0.187009123738962 0.00591707421229706 NA NA NA hsa-miR-29a-5p FLT1 1.89519956688438 1.03453349363915e-11 -0.853716821222124 3.80935455614656e-05 MirTarget -0.175417658210396 1.24014458232337e-05 NA NA NA hsa-miR-339-5p FLT1 0.536997313601114 0.0488090394176611 -0.853716821222124 3.80935455614656e-05 miRanda -0.139246508572304 7.36899128620129e-05 NA NA NA hsa-miR-361-5p FLT1 0.21454431962475 0.0800957579368424 -0.853716821222124 3.80935455614656e-05 miRanda -0.241986249183725 0.00246609230162922 NA NA NA hsa-miR-429 FLT1 2.3794516574089 1.72813419703734e-13 -0.853716821222124 3.80935455614656e-05 MirTarget;miRanda;miRNATAP -0.190194777628028 7.66169417536964e-10 NA NA NA hsa-miR-501-5p FLT1 0.411357595674671 0.10435288464149 -0.853716821222124 3.80935455614656e-05 mirMAP -0.140670170116836 0.000205354183101303 NA NA NA hsa-miR-505-5p FLT1 0.77207328399883 0.00479562389564013 -0.853716821222124 3.80935455614656e-05 MirTarget -0.142598381971651 4.34386719692121e-05 NA NA NA hsa-miR-590-3p FLT1 0.83851360565783 0.00129224433453587 -0.853716821222124 3.80935455614656e-05 miRanda -0.142772954752402 0.00120378252750183 NA NA NA hsa-miR-664a-5p FLT1 -0.0936480603578111 0.662274905077117 -0.853716821222124 3.80935455614656e-05 MirTarget -0.204555059118557 8.75678517451646e-06 NA NA NA hsa-miR-93-5p FLT1 1.50844106515467 1.83836866996875e-12 -0.853716821222124 3.80935455614656e-05 MirTarget;miRNATAP -0.199814602709946 4.71374653185103e-06 NA NA NA hsa-miR-542-3p FLT3 1.62226640768239 2.6427102465476e-10 -1.00556785809288 0.00338224604235755 miRanda -0.160784295906754 0.00804059626624641 NA NA NA hsa-miR-429 FLT4 2.3794516574089 1.72813419703734e-13 -1.56395694632575 7.75833948395905e-12 miRanda;miRNATAP -0.218735391764706 2.59527657323593e-10 NA NA NA hsa-let-7g-5p FN1 0.0837630831079359 0.583083118232597 -0.566807120885738 0.0430749263359056 miRTarBase -0.230921745913925 0.00707072028935924 NA NA NA hsa-miR-16-1-3p FN1 1.50034693398929 6.63958242991125e-10 -0.566807120885738 0.0430749263359056 mirMAP -0.214581262852692 0.000944439200242472 NA NA NA hsa-miR-200b-3p FN1 1.55157578247391 4.83790020897188e-09 -0.566807120885738 0.0430749263359056 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.403184695081414 2.89880355787601e-18 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-200c-3p FN1 0.380533388300368 0.0842181838538353 -0.566807120885738 0.0430749263359056 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.472021950323672 1.11184411677362e-16 NA NA NA hsa-miR-26b-5p FN1 0.72362441215247 4.7794659748036e-05 -0.566807120885738 0.0430749263359056 miRNAWalker2_validate -0.36304072958237 4.39342083602747e-07 NA NA NA hsa-miR-429 FN1 2.3794516574089 1.72813419703734e-13 -0.566807120885738 0.0430749263359056 MirTarget;PITA;miRanda;miRNATAP -0.310801283540026 4.05201869726347e-14 NA NA NA hsa-miR-96-5p FN1 3.0381097138467 4.40362891630201e-24 -0.566807120885738 0.0430749263359056 MirTarget;TargetScan -0.218740148864903 3.00161127592485e-06 NA NA NA hsa-miR-130b-3p FOXO3 1.83046548750752 5.04753914574694e-13 -0.895413795189264 1.89870901444741e-09 mirMAP -0.122021132272624 1.465303741789e-05 NA NA NA hsa-miR-130b-5p FOXO3 1.53645187062942 1.10498816261505e-08 -0.895413795189264 1.89870901444741e-09 mirMAP;miRNATAP -0.118857986673794 2.77409555824153e-06 NA NA NA hsa-miR-182-5p FOXO3 3.21839823004635 5.13049145201115e-39 -0.895413795189264 1.89870901444741e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.11602000250242 7.0784861198369e-06 24519909;24865442;19188590 Sp1 increased expression of miR-182 which was then recruited to the 3'-untranslated region of FOXO3 mRNA to silence its translational activity; Repression of FOXO3 expression in the miR-182 knockdown cells partially reversed this effect suggesting that miR-182 promotes cancer cell growth and inhibits cancer metastatic activity by regulating the expression of FOXO3; In conclusion in the early stages of lung cancer progression Sp1 stimulates miR-182 expression which in turn decreases FOXO3 expression; In the late stages Sp1 and miR-182 decline thus increasing FOXO3 expression which leads to lung metastasis;Immunohistochemical analysis revealed that the levels of FOXO1 and FOXO3A two potential miR-182 targets are reduced in AA tumors;Aberrant miR 182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia associated transcription factor; We further show that miR-182 over-expression promotes migration and survival by directly repressing microphthalmia-associated transcription factor-M and FOXO3 whereas enhanced expression of either microphthalmia-associated transcription factor-M or FOXO3 blocks miR-182's proinvasive effects; In human tissues expression of miR-182 increases with progression from primary to metastatic melanoma and inversely correlates with FOXO3 and microphthalmia-associated transcription factor levels staging;progression;metastasis;;metastasis;poor survival;progression lung cancer;colon cancer;melanoma hsa-miR-29a-5p FOXO3 1.89519956688438 1.03453349363915e-11 -0.895413795189264 1.89870901444741e-09 mirMAP -0.16106957536559 2.60735655881159e-08 NA NA NA hsa-miR-29b-3p FOXO3 3.10527711861309 3.01242507282711e-32 -0.895413795189264 1.89870901444741e-09 miRNATAP -0.15089756439038 5.78529972095117e-10 NA NA NA hsa-miR-301a-3p FOXO3 2.70198002906399 1.56420889710984e-14 -0.895413795189264 1.89870901444741e-09 mirMAP -0.128998765058196 4.56954689578401e-08 NA NA NA hsa-miR-335-3p FOXO3 1.51116383169018 6.88553098788624e-13 -0.895413795189264 1.89870901444741e-09 mirMAP -0.158833013693076 7.73965982660344e-07 NA NA NA hsa-miR-454-3p FOXO3 1.49453641052169 4.46235742871434e-09 -0.895413795189264 1.89870901444741e-09 mirMAP -0.166291092791885 1.95275725642239e-07 NA NA NA hsa-miR-576-5p FOXO3 1.02693643167056 1.14846964470173e-06 -0.895413795189264 1.89870901444741e-09 mirMAP -0.117431490496234 0.000330656644143427 NA NA NA hsa-miR-590-3p FOXO3 0.83851360565783 0.00129224433453587 -0.895413795189264 1.89870901444741e-09 PITA;miRanda;mirMAP;miRNATAP -0.107745802969036 0.000753023435193478 NA NA NA hsa-miR-590-5p FOXO3 2.07441240363458 4.95240551694843e-14 -0.895413795189264 1.89870901444741e-09 miRanda -0.152014859052802 5.38253066000642e-07 NA NA NA hsa-miR-93-3p FOXO3 1.07631808403007 1.63747525692813e-05 -0.895413795189264 1.89870901444741e-09 miRNATAP -0.108500973715839 8.57528951669449e-05 NA NA NA hsa-miR-96-5p FOXO3 3.0381097138467 4.40362891630201e-24 -0.895413795189264 1.89870901444741e-09 miRNAWalker2_validate;TargetScan;miRNATAP -0.185186930259903 9.08357146454348e-14 25286764;21203424 Expression of microRNA 96 and its potential functions by targeting FOXO3 in non small cell lung cancer; Dual-luciferase reporter assay and Western blotting were used to verify whether FOXO3 was a potential major target gene of miR-96; Finally the effect of FOXO3 on miR-96-induced cell survival was determined by transfection of the genes expressing FOXO3 lacking 3'UTR and miR-96; Western blotting and dual-luciferase reporter assays demonstrated that miR-96 can bind to the putative seed region in FOXO3 mRNA 3'UTR and can significantly lower the expression of FOXO3; The introduction of FOXO3 cDNA without 3'UTR restored miR-96 induced cell apoptosis and invasion; Downregulation of miR-96 inhibits invasion and promotes apoptosis in NSCLC cells A549 and SPC-A-1 by targeting FOXO3;Unregulated miR 96 induces cell proliferation in human breast cancer by downregulating transcriptional factor FOXO3a; Moreover we demonstrated that miR-96 downregulated FOXO3a expression by directly targeting the FOXO3a 3'-untranslated region; Taken together our results suggest that miR-96 may play an important role in promoting proliferation of human breast cancer cells and present a novel mechanism of miRNA-mediated direct suppression of FOXO3a expression in cancer cells poor survival; lung squamous cell cancer;breast cancer hsa-miR-142-3p GHR 3.98476449801341 1.56256182021111e-35 -2.71079913438272 1.27737998879726e-18 MirTarget;PITA;miRanda;miRNATAP -0.240178402806526 1.0549361908914e-08 NA NA NA hsa-miR-15a-5p GHR 1.62575353599172 1.55312121019827e-19 -2.71079913438272 1.27737998879726e-18 MirTarget;miRNATAP -0.400842253213854 3.19898591344609e-07 NA NA NA hsa-miR-16-2-3p GHR 0.503964803530872 0.0263648405197492 -2.71079913438272 1.27737998879726e-18 mirMAP -0.318740264994176 5.63668150944797e-06 NA NA NA hsa-miR-16-5p GHR 0.749619098384047 4.11649450706988e-06 -2.71079913438272 1.27737998879726e-18 MirTarget;miRNATAP -0.370703042948598 3.89836833751239e-05 NA NA NA hsa-miR-29a-5p GHR 1.89519956688438 1.03453349363915e-11 -2.71079913438272 1.27737998879726e-18 mirMAP;miRNATAP -0.407579980761912 1.93886667487704e-11 NA NA NA hsa-miR-3607-3p GHR 2.4103172144469 2.69039449048047e-08 -2.71079913438272 1.27737998879726e-18 mirMAP -0.107560273031406 0.00128183659789109 NA NA NA hsa-miR-421 GHR 0.170525317701774 0.535277026680289 -2.71079913438272 1.27737998879726e-18 miRanda -0.257993079486087 8.6932681900049e-06 NA NA NA hsa-miR-424-5p GHR 1.26485330287919 6.1498991028257e-06 -2.71079913438272 1.27737998879726e-18 MirTarget;miRNATAP -0.252527058710918 1.09153368104669e-06 NA NA NA hsa-miR-429 GHR 2.3794516574089 1.72813419703734e-13 -2.71079913438272 1.27737998879726e-18 miRanda;miRNATAP -0.197468687622676 3.83302326881649e-05 NA NA NA hsa-miR-590-3p GHR 0.83851360565783 0.00129224433453587 -2.71079913438272 1.27737998879726e-18 mirMAP -0.442688732144415 2.6819424381772e-11 NA NA NA hsa-miR-624-5p GHR -0.0554776050468686 0.829845479813552 -2.71079913438272 1.27737998879726e-18 MirTarget -0.287083525536995 7.08976390565227e-06 NA NA NA hsa-miR-651-5p GHR 1.67013048675395 1.61458229225137e-07 -2.71079913438272 1.27737998879726e-18 MirTarget -0.253725916706089 7.28248825124979e-06 NA NA NA hsa-miR-7-1-3p GHR 2.61364240402652 1.98959237815786e-32 -2.71079913438272 1.27737998879726e-18 MirTarget;mirMAP -0.49394038620697 1.28503004114502e-14 NA NA NA hsa-miR-103a-3p GNB1 0.538497806383155 1.88134691850591e-05 -0.113359179439685 0.195982693610462 miRNAWalker2_validate -0.117501466818173 0.000245189860341104 NA NA NA hsa-miR-455-5p GNB1 1.36946341828134 5.05118627562807e-08 -0.113359179439685 0.195982693610462 miRanda -0.108101477167502 1.61497275462324e-09 NA NA NA hsa-miR-30b-3p GNB3 -1.20976737190106 2.63726511331003e-06 1.69073826499078 7.74067547508589e-08 MirTarget -0.179197209145642 0.00153276442471823 NA NA NA hsa-miR-21-5p GNB4 4.38165933891779 1.52536633902505e-92 -0.773241223004692 8.02059608334668e-05 miRNAWalker2_validate -0.107864200716027 0.00179440282483582 NA NA NA hsa-miR-27b-3p GNB4 0.236438984240408 0.12263510345883 -0.773241223004692 8.02059608334668e-05 miRNAWalker2_validate -0.210879510550501 0.000426209888920114 NA NA NA hsa-miR-29a-3p GNB4 0.101650412194573 0.573201097011668 -0.773241223004692 8.02059608334668e-05 MirTarget -0.168333381395 0.000894636314361531 NA NA NA hsa-miR-29b-3p GNB4 3.10527711861309 3.01242507282711e-32 -0.773241223004692 8.02059608334668e-05 MirTarget -0.189703366062938 2.34684961828285e-09 NA NA NA hsa-miR-3065-5p GNB4 0.653308707552535 0.0999497219778851 -0.773241223004692 8.02059608334668e-05 mirMAP -0.121122292313831 8.89741281675571e-07 NA NA NA hsa-miR-429 GNB4 2.3794516574089 1.72813419703734e-13 -0.773241223004692 8.02059608334668e-05 miRanda -0.240268760697607 6.09768937468449e-17 NA NA NA hsa-miR-501-5p GNB4 0.411357595674671 0.10435288464149 -0.773241223004692 8.02059608334668e-05 mirMAP -0.113445591286251 0.001569081902348 NA NA NA hsa-miR-93-5p GNB4 1.50844106515467 1.83836866996875e-12 -0.773241223004692 8.02059608334668e-05 miRNAWalker2_validate -0.116932524718652 0.00488189460124817 NA NA NA hsa-miR-96-5p GNB4 3.0381097138467 4.40362891630201e-24 -0.773241223004692 8.02059608334668e-05 MirTarget -0.251282720636843 6.94534802266421e-15 NA NA NA hsa-miR-342-3p GNB5 -0.128691966564961 0.561034080130801 0.195294444380377 0.0983508797090191 miRanda -0.127429687786504 1.6487338390712e-07 NA NA NA hsa-miR-107 GNG12 0.658676029898313 5.11480446318819e-07 -0.481052982891586 0.0106970234636918 miRanda -0.240152271925136 0.000296272815140921 NA NA NA hsa-miR-590-3p GNG12 0.83851360565783 0.00129224433453587 -0.481052982891586 0.0106970234636918 miRanda;mirMAP -0.106371542166068 0.00772124644373765 NA NA NA hsa-miR-590-5p GNG12 2.07441240363458 4.95240551694843e-14 -0.481052982891586 0.0106970234636918 PITA -0.223723753830493 2.62733560738329e-09 NA NA NA hsa-miR-96-5p GNG12 3.0381097138467 4.40362891630201e-24 -0.481052982891586 0.0106970234636918 TargetScan -0.178457232594575 1.23065278598398e-08 NA NA NA hsa-miR-21-5p GNG2 4.38165933891779 1.52536633902505e-92 -1.07252911873911 1.7090824521982e-08 miRNATAP -0.195454981949984 4.65483751845796e-09 NA NA NA hsa-miR-29b-3p GNG2 3.10527711861309 3.01242507282711e-32 -1.07252911873911 1.7090824521982e-08 miRNATAP -0.142780740359251 5.16429361551287e-06 NA NA NA hsa-miR-324-5p GNG2 1.06955541886548 5.39722006604758e-05 -1.07252911873911 1.7090824521982e-08 miRanda -0.221830150375793 1.13086546193881e-11 NA NA NA hsa-miR-335-3p GNG2 1.51116383169018 6.88553098788624e-13 -1.07252911873911 1.7090824521982e-08 mirMAP -0.240567600489885 3.49917850638484e-09 NA NA NA hsa-miR-429 GNG2 2.3794516574089 1.72813419703734e-13 -1.07252911873911 1.7090824521982e-08 miRanda;miRNATAP -0.204223932362233 6.14680056882904e-13 NA NA NA hsa-miR-500a-5p GNG2 0.648155655714409 0.0104657432932038 -1.07252911873911 1.7090824521982e-08 mirMAP -0.11274419739223 0.00174283911743799 NA NA NA hsa-miR-576-5p GNG2 1.02693643167056 1.14846964470173e-06 -1.07252911873911 1.7090824521982e-08 mirMAP -0.177380920431951 1.97687565002678e-05 NA NA NA hsa-miR-590-5p GNG2 2.07441240363458 4.95240551694843e-14 -1.07252911873911 1.7090824521982e-08 miRanda;miRNATAP -0.245120778111592 1.60106027155252e-10 NA NA NA hsa-miR-181a-2-3p GNG4 -0.0760679893470186 0.687414621472156 1.72312254651559 0.00587807376629479 MirTarget -0.521848705759067 0.000687313416764603 NA NA NA hsa-miR-200b-3p GNG4 1.55157578247391 4.83790020897188e-09 1.72312254651559 0.00587807376629479 mirMAP -0.306715881883784 0.00426489766083202 NA NA NA hsa-miR-203a-3p GNG4 1.06866854356847 0.00389979689199624 1.72312254651559 0.00587807376629479 MirTarget -0.259839165085709 0.000811028160640383 NA NA NA hsa-miR-3065-5p GNG4 0.653308707552535 0.0999497219778851 1.72312254651559 0.00587807376629479 mirMAP -0.432702216687085 3.08252945104106e-08 NA NA NA hsa-miR-338-3p GNG4 0.726843067232002 0.0506251324215494 1.72312254651559 0.00587807376629479 miRanda -0.493337283401031 9.46534696968155e-11 NA NA NA hsa-miR-452-5p GNG4 0.637123950346362 0.0458173998136196 1.72312254651559 0.00587807376629479 mirMAP -0.292531418034242 0.00120833949138994 NA NA NA hsa-miR-141-3p GNG7 3.36993755486106 5.42939251147195e-32 -1.41246014447214 2.13793630570999e-07 MirTarget;TargetScan;miRNATAP -0.189167674111421 4.10841385093332e-06 NA NA NA hsa-miR-17-3p GNG7 1.36706429551147 4.60388403547821e-13 -1.41246014447214 2.13793630570999e-07 mirMAP -0.374874020476443 8.0369641742108e-09 NA NA NA hsa-miR-182-5p GNG7 3.21839823004635 5.13049145201115e-39 -1.41246014447214 2.13793630570999e-07 mirMAP -0.19361001460947 3.99850320331774e-05 NA NA NA hsa-miR-185-3p GNG7 -0.377490365509078 0.093653288903368 -1.41246014447214 2.13793630570999e-07 mirMAP -0.293431565357679 1.60460735745411e-07 NA NA NA hsa-miR-18a-5p GNG7 1.37435209536521 9.2173853686829e-06 -1.41246014447214 2.13793630570999e-07 mirMAP -0.357133892265359 5.57343004386596e-17 NA NA NA hsa-miR-193b-5p GNG7 0.179695858885499 0.55521472494233 -1.41246014447214 2.13793630570999e-07 mirMAP -0.135144229514802 0.00120517117584307 NA NA NA hsa-miR-3127-5p GNG7 0.382717393698386 0.11535780874721 -1.41246014447214 2.13793630570999e-07 mirMAP -0.141400895796466 0.00695830869520311 NA NA NA hsa-miR-590-3p GNG7 0.83851360565783 0.00129224433453587 -1.41246014447214 2.13793630570999e-07 PITA;miRanda;mirMAP -0.22363480187195 0.000119744484254228 NA NA NA hsa-miR-671-5p GNG7 2.24156654191798 2.10433241567652e-14 -1.41246014447214 2.13793630570999e-07 mirMAP -0.24848614597746 6.35445092234873e-07 NA NA NA hsa-miR-766-3p GNG7 0.0784037775118556 0.760091599198293 -1.41246014447214 2.13793630570999e-07 MirTarget -0.160873184528654 0.00116612286541079 NA NA NA hsa-miR-9-5p GNG7 4.99250901331516 2.59132733422801e-19 -1.41246014447214 2.13793630570999e-07 mirMAP -0.155921330432605 2.93551118394192e-13 NA NA NA hsa-miR-92a-3p GNG7 -0.136362762339122 0.493412263619364 -1.41246014447214 2.13793630570999e-07 miRNAWalker2_validate -0.230320816939184 0.000321658197767431 NA NA NA hsa-miR-940 GNG7 0.011138136211269 0.974925352379525 -1.41246014447214 2.13793630570999e-07 MirTarget -0.184899914783095 3.81240270334476e-06 NA NA NA hsa-miR-96-5p GNG7 3.0381097138467 4.40362891630201e-24 -1.41246014447214 2.13793630570999e-07 mirMAP -0.21085275506079 4.76896318898963e-06 NA NA NA hsa-miR-219a-1-3p GNGT2 0.42818839093396 0.0892433909993089 -1.32163682528978 7.3757518477017e-09 MirTarget -0.171342381827645 8.34792017996791e-05 NA NA NA hsa-miR-27b-3p GRB2 0.236438984240408 0.12263510345883 -0.210706496557246 0.0100478898753454 MirTarget;miRNATAP -0.113414213940692 3.83461454675988e-06 NA NA NA hsa-miR-146b-5p GSK3B 1.0922867893808 5.63754607494775e-06 -0.319504109269896 0.00509554373726706 miRanda -0.120312213108812 1.7975506993317e-08 NA NA NA hsa-miR-181a-5p GSK3B -0.375429731222937 0.0562142867129802 -0.319504109269896 0.00509554373726706 mirMAP -0.132846513131072 5.69040547461192e-07 NA NA NA hsa-miR-181b-5p GSK3B 0.668793269169928 0.000239998092406404 -0.319504109269896 0.00509554373726706 mirMAP -0.140685251831582 8.58107584485064e-07 NA NA NA hsa-miR-199a-5p GSK3B 1.3057193856884 2.38429382751645e-08 -0.319504109269896 0.00509554373726706 PITA;miRanda;miRNATAP -0.121841478766833 2.53412001096022e-08 NA NA NA hsa-miR-199b-5p GSK3B 2.13822205171062 4.56262988762436e-15 -0.319504109269896 0.00509554373726706 PITA;miRanda;miRNATAP -0.100321514688164 5.34622168763933e-08 NA NA NA hsa-miR-26b-5p GSK3B 0.72362441215247 4.7794659748036e-05 -0.319504109269896 0.00509554373726706 miRNATAP -0.157953924331919 5.91797033962096e-08 NA NA NA hsa-miR-29a-3p GSK3B 0.101650412194573 0.573201097011668 -0.319504109269896 0.00509554373726706 miRNATAP -0.116338386401065 6.72434775060363e-05 NA NA NA hsa-miR-29b-3p GSK3B 3.10527711861309 3.01242507282711e-32 -0.319504109269896 0.00509554373726706 miRTarBase;miRNATAP -0.120996712920378 3.47881082150066e-11 NA NA NA hsa-miR-342-3p GSK3B -0.128691966564961 0.561034080130801 -0.319504109269896 0.00509554373726706 miRanda -0.118246314250764 5.34302901573344e-07 NA NA NA hsa-miR-664a-3p GSK3B 0.443077463053857 0.0214248925850984 -0.319504109269896 0.00509554373726706 mirMAP -0.143789851437302 1.0690658876804e-07 NA NA NA hsa-let-7a-3p HGF 0.167285443861993 0.431834813181487 -1.46782534168535 1.69011867186688e-05 mirMAP -0.220233871328952 0.00866054421617636 NA NA NA hsa-miR-141-3p HGF 3.36993755486106 5.42939251147195e-32 -1.46782534168535 1.69011867186688e-05 MirTarget;TargetScan -0.400868595787034 1.23049606342836e-15 NA NA NA hsa-miR-200a-3p HGF 3.14766878548496 1.32850889777422e-21 -1.46782534168535 1.69011867186688e-05 MirTarget -0.253494768373625 5.0583757364239e-08 NA NA NA hsa-miR-203a-3p HGF 1.06866854356847 0.00389979689199624 -1.46782534168535 1.69011867186688e-05 MirTarget -0.153601511229596 0.000301513481806427 NA NA NA hsa-miR-26b-5p HGF 0.72362441215247 4.7794659748036e-05 -1.46782534168535 1.69011867186688e-05 MirTarget;miRNATAP -0.305370801964651 0.000589397366341262 NA NA NA hsa-miR-29a-5p HGF 1.89519956688438 1.03453349363915e-11 -1.46782534168535 1.69011867186688e-05 mirMAP -0.289655913024973 1.20483934738604e-05 NA NA NA hsa-miR-30b-5p HGF 0.358144314839612 0.138026229059594 -1.46782534168535 1.69011867186688e-05 mirMAP -0.228949192247152 0.000487341920331379 NA NA NA hsa-miR-421 HGF 0.170525317701774 0.535277026680289 -1.46782534168535 1.69011867186688e-05 miRanda -0.191831411356542 0.00221575379454529 NA NA NA hsa-miR-429 HGF 2.3794516574089 1.72813419703734e-13 -1.46782534168535 1.69011867186688e-05 miRanda -0.328662037767097 1.0453775228151e-10 NA NA NA hsa-miR-542-3p HGF 1.62226640768239 2.6427102465476e-10 -1.46782534168535 1.69011867186688e-05 miRanda -0.190590602252299 0.00164459151192755 NA NA NA hsa-miR-590-3p HGF 0.83851360565783 0.00129224433453587 -1.46782534168535 1.69011867186688e-05 miRanda;mirMAP -0.347975466531176 1.44513714212125e-06 NA NA NA hsa-miR-590-5p HGF 2.07441240363458 4.95240551694843e-14 -1.46782534168535 1.69011867186688e-05 miRanda -0.408173134036666 2.61219989107118e-09 NA NA NA hsa-miR-651-5p HGF 1.67013048675395 1.61458229225137e-07 -1.46782534168535 1.69011867186688e-05 MirTarget -0.277915118196018 4.80995997083731e-06 NA NA NA hsa-miR-7-1-3p HGF 2.61364240402652 1.98959237815786e-32 -1.46782534168535 1.69011867186688e-05 mirMAP -0.28714079677471 4.59341965745208e-05 NA NA NA hsa-let-7a-5p HRAS -1.37014061604018 3.11451492971224e-14 0.139800610267073 0.358123351398595 miRNAWalker2_validate;miRTarBase -0.142144334211175 0.000164893588817854 18344688;20033209;20607356;23134218;19323605 Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;;progression lung cancer;lung cancer;glioblastoma;lung squamous cell cancer;pancreatic cancer hsa-miR-143-3p HRAS -1.21021691908494 5.70938667332876e-06 0.139800610267073 0.358123351398595 miRNAWalker2_validate;miRTarBase -0.125376896055055 1.11873626270013e-06 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-30c-5p HSP90AA1 -0.327319105755825 0.123595832152687 0.250039819590016 0.0777222566710175 miRNAWalker2_validate -0.249342542531181 5.50707515539743e-17 NA NA NA hsa-miR-30e-5p HSP90AA1 1.60414100786743 3.78951090573667e-19 0.250039819590016 0.0777222566710175 miRNAWalker2_validate -0.129510807096954 0.000214244192342973 NA NA NA hsa-miR-362-5p HSP90AA1 0.658947634569393 0.0243306847205756 0.250039819590016 0.0777222566710175 MirTarget;PITA -0.116545541978849 2.48090601437059e-07 NA NA NA hsa-miR-500b-5p HSP90AA1 0.647661565914957 0.0105051864007712 0.250039819590016 0.0777222566710175 MirTarget -0.125413844268526 1.71733355555542e-06 NA NA NA hsa-miR-320a HSP90AB1 -0.961144925954715 1.62478794429204e-08 0.575826241679328 4.14290757287217e-06 miRNAWalker2_validate -0.142449708444912 2.28659396269736e-05 NA NA NA hsa-miR-1-3p HSP90B1 -1.48412019995919 0.000242034342580425 0.804665976849464 5.31396083187244e-08 MirTarget -0.138308155656202 1.39767902294158e-14 NA NA NA hsa-miR-150-5p HSP90B1 -0.702328520623782 0.0215316651134431 0.804665976849464 5.31396083187244e-08 MirTarget -0.145131665761144 5.27694443480274e-11 NA NA NA hsa-miR-181a-5p HSP90B1 -0.375429731222937 0.0562142867129802 0.804665976849464 5.31396083187244e-08 MirTarget -0.24898526031393 4.64679673279723e-13 NA NA NA hsa-miR-181b-5p HSP90B1 0.668793269169928 0.000239998092406404 0.804665976849464 5.31396083187244e-08 MirTarget -0.129728934466873 0.000603848991796077 NA NA NA hsa-miR-129-5p IBSP -0.405735314747643 0.341485636033577 3.12079073384227 3.73599016925833e-07 miRanda -0.176966157284618 0.00876074119982819 25344911 Using microarray and BSP Bisulfate Sequencing PCR assays we found that compared with the parent SGC7901/VCR cells expression of miR-129-5p was restored in SGC7901/VCR gastric cancer multi-drug resistant cell line treated by de-methylation reagent 5-AZA-dC gastric cancer hsa-miR-139-5p IBSP -2.26625553116965 7.22375119369519e-16 3.12079073384227 3.73599016925833e-07 miRanda -0.467108451687509 1.8563860234608e-06 NA NA NA hsa-miR-106b-5p IFNAR2 1.47447672652218 1.32004094930462e-13 0.140550219738166 0.332339267782678 miRNAWalker2_validate -0.1472266221605 5.70106557312633e-06 NA NA NA hsa-miR-141-3p IFNAR2 3.36993755486106 5.42939251147195e-32 0.140550219738166 0.332339267782678 mirMAP -0.10951748988711 3.35192739367357e-07 NA NA NA hsa-miR-330-5p IFNAR2 0.168520831101569 0.336433937906706 0.140550219738166 0.332339267782678 miRanda -0.13552778390331 0.000387750870407834 NA NA NA hsa-miR-484 IFNAR2 -0.228576985124486 0.244112867390855 0.140550219738166 0.332339267782678 miRNAWalker2_validate -0.11120746642306 0.00109782681141026 NA NA NA hsa-miR-130b-3p IGF1 1.83046548750752 5.04753914574694e-13 -0.878839289406132 0.00545024687919024 MirTarget -0.208984208427567 0.000411905460472152 NA NA NA hsa-miR-15b-3p IGF1 0.804736041893915 0.000400279611457186 -0.878839289406132 0.00545024687919024 mirMAP -0.294250039955051 1.19648006053704e-05 NA NA NA hsa-miR-16-1-3p IGF1 1.50034693398929 6.63958242991125e-10 -0.878839289406132 0.00545024687919024 mirMAP -0.346697103874593 2.00512825999278e-06 NA NA NA hsa-miR-181b-5p IGF1 0.668793269169928 0.000239998092406404 -0.878839289406132 0.00545024687919024 mirMAP -0.277079678771502 0.000542842928980559 NA NA NA hsa-miR-186-5p IGF1 0.852175445703945 6.88885738584309e-10 -0.878839289406132 0.00545024687919024 mirMAP -0.579822063247168 2.4486690275545e-08 NA NA NA hsa-miR-19a-3p IGF1 2.11776595911517 7.07663078397156e-10 -0.878839289406132 0.00545024687919024 MirTarget -0.295619339516778 1.77416468047122e-09 NA NA NA hsa-miR-19b-1-5p IGF1 1.71217036351784 3.28561659177495e-12 -0.878839289406132 0.00545024687919024 mirMAP -0.353413690663535 1.05429610809513e-07 NA NA NA hsa-miR-19b-3p IGF1 2.10868505662119 5.40846613768389e-17 -0.878839289406132 0.00545024687919024 MirTarget -0.332913498199372 1.17742302735622e-08 NA NA NA hsa-miR-20a-3p IGF1 2.51803599558247 4.92479325298629e-13 -0.878839289406132 0.00545024687919024 mirMAP -0.27191171788815 1.96054552687628e-07 NA NA NA hsa-miR-26b-5p IGF1 0.72362441215247 4.7794659748036e-05 -0.878839289406132 0.00545024687919024 mirMAP -0.268812581966602 0.00103479699566484 NA NA NA hsa-miR-29b-3p IGF1 3.10527711861309 3.01242507282711e-32 -0.878839289406132 0.00545024687919024 MirTarget -0.214642092755044 3.159014552534e-05 25592039 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 IGF1 3' untranslated region 3'UTR; IGF1 an activator of PI3K/Akt signaling was confirmed as a novel target of miR-29b colorectal cancer hsa-miR-301a-3p IGF1 2.70198002906399 1.56420889710984e-14 -0.878839289406132 0.00545024687919024 MirTarget -0.262923939050952 1.05879075346237e-07 NA NA NA hsa-miR-3065-5p IGF1 0.653308707552535 0.0999497219778851 -0.878839289406132 0.00545024687919024 mirMAP -0.125233094164205 0.00171064732391524 NA NA NA hsa-miR-362-5p IGF1 0.658947634569393 0.0243306847205756 -0.878839289406132 0.00545024687919024 mirMAP -0.262372836237127 2.21880393042342e-07 NA NA NA hsa-miR-450b-5p IGF1 1.69248953402469 1.96052058003353e-07 -0.878839289406132 0.00545024687919024 MirTarget;PITA;mirMAP;miRNATAP -0.155478745947113 0.00168638246971297 NA NA NA hsa-miR-454-3p IGF1 1.49453641052169 4.46235742871434e-09 -0.878839289406132 0.00545024687919024 MirTarget -0.353703568576877 1.23901415685651e-07 NA NA NA hsa-miR-576-5p IGF1 1.02693643167056 1.14846964470173e-06 -0.878839289406132 0.00545024687919024 PITA;mirMAP;miRNATAP -0.319877018116458 2.70279102064343e-06 NA NA NA hsa-miR-590-3p IGF1 0.83851360565783 0.00129224433453587 -0.878839289406132 0.00545024687919024 MirTarget;miRanda;mirMAP;miRNATAP -0.218208367579052 0.00112544995000528 NA NA NA hsa-miR-629-5p IGF1 1.31657090341737 1.45711558652127e-12 -0.878839289406132 0.00545024687919024 mirMAP -0.206791424784461 0.0072984659842286 NA NA NA hsa-let-7i-5p IGF1R 0.605080599172936 1.48406814653206e-06 -0.178629243747184 0.436534266278541 MirTarget;miRNATAP -0.256694243116189 0.00240085762971046 NA NA NA hsa-miR-146b-5p IGF1R 1.0922867893808 5.63754607494775e-06 -0.178629243747184 0.436534266278541 miRanda -0.303094486796453 1.088821796606e-12 NA NA NA hsa-miR-148a-5p IGF1R 1.45633512586855 1.81792463521257e-08 -0.178629243747184 0.436534266278541 mirMAP -0.119635539017428 0.00292895606929232 NA NA NA hsa-miR-150-5p IGF1R -0.702328520623782 0.0215316651134431 -0.178629243747184 0.436534266278541 mirMAP -0.143209266356849 3.01493577213741e-05 NA NA NA hsa-miR-155-5p IGF1R 0.813513839059142 0.000608282725633232 -0.178629243747184 0.436534266278541 mirMAP -0.268968974534585 7.32602920272678e-10 NA NA NA hsa-miR-15a-5p IGF1R 1.62575353599172 1.55312121019827e-19 -0.178629243747184 0.436534266278541 miRNATAP -0.193944653970012 0.000607738723136944 NA NA NA hsa-miR-16-1-3p IGF1R 1.50034693398929 6.63958242991125e-10 -0.178629243747184 0.436534266278541 mirMAP -0.194764020480667 0.00023684295920273 NA NA NA hsa-miR-29b-1-5p IGF1R 1.71024742617744 3.64915691793611e-09 -0.178629243747184 0.436534266278541 mirMAP -0.109156019731015 0.00228581523963077 NA NA NA hsa-miR-342-3p IGF1R -0.128691966564961 0.561034080130801 -0.178629243747184 0.436534266278541 mirMAP -0.218844007083102 4.21137505967977e-06 NA NA NA hsa-miR-342-5p IGF1R -0.382174669348421 0.0896996965047193 -0.178629243747184 0.436534266278541 mirMAP -0.133834784601358 0.00441518826245992 NA NA NA hsa-miR-378a-3p IGF1R -2.0140903990983 1.146745431034e-18 -0.178629243747184 0.436534266278541 miRTarBase;MirTarget;miRNATAP -0.12672222415071 0.00445290085061963 24119742;25427715;24412052 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS; MiR-378a-3p over-expression in an RMS-derived cell line suppressed IGF1R expression and affected phosphorylated-Akt protein levels;Furthermore miR-378a-3p over-expression or down-regulation could inhibit or enhance insulin-like growth factor 1 receptor IGF1R expression in CRC cells; There was a significantly negative correlation between IGF1R protein expression and miR-378a-3p expression in CRC tissues ;; liver cancer;sarcoma;colorectal cancer hsa-miR-500a-3p IGF1R -0.137335632790721 0.545751862031252 -0.178629243747184 0.436534266278541 mirMAP -0.175210626907922 0.000163434267424394 NA NA NA hsa-miR-532-5p IGF1R 0.576620898517708 0.0023245812680956 -0.178629243747184 0.436534266278541 miRNATAP -0.14810963695722 0.00808068095369003 NA NA NA hsa-miR-141-3p IGF2 3.36993755486106 5.42939251147195e-32 -1.08658013151097 0.0418048512628873 MirTarget;TargetScan -0.284835821692114 0.000367809561255195 NA NA NA hsa-miR-150-5p IGF2 -0.702328520623782 0.0215316651134431 -1.08658013151097 0.0418048512628873 miRNAWalker2_validate -0.236779050056331 0.00323554650957194 NA NA NA hsa-miR-192-5p IGF2 2.03412119423736 1.6357945826287e-05 -1.08658013151097 0.0418048512628873 mirMAP -0.140839590585574 0.00635848251610975 NA NA NA hsa-miR-19b-3p IGF2 2.10868505662119 5.40846613768389e-17 -1.08658013151097 0.0418048512628873 mirMAP -0.268219110705068 0.00715823274343047 NA NA NA hsa-miR-335-3p IGF2 1.51116383169018 6.88553098788624e-13 -1.08658013151097 0.0418048512628873 MirTarget -0.313803107897319 0.00612624794698323 NA NA NA hsa-miR-107 IKBKG 0.658676029898313 5.11480446318819e-07 0.0843830838323729 0.544710841322622 miRanda -0.126711425730293 0.00969342977912645 NA NA NA hsa-miR-143-3p IKBKG -1.21021691908494 5.70938667332876e-06 0.0843830838323729 0.544710841322622 mirMAP -0.162693115202678 2.58257152475095e-12 NA NA NA hsa-miR-17-3p IKBKG 1.36706429551147 4.60388403547821e-13 0.0843830838323729 0.544710841322622 mirMAP -0.124943383525099 0.000155383572679206 NA NA NA hsa-miR-24-3p IKBKG -0.0357874587555003 0.785865078836504 0.0843830838323729 0.544710841322622 mirMAP -0.14327021053209 0.00372994900140062 NA NA NA hsa-miR-330-3p IKBKG -0.716924999893351 0.000796236278616087 0.0843830838323729 0.544710841322622 mirMAP -0.174026313241355 3.45303704238481e-09 NA NA NA hsa-miR-3065-3p IL2RA 0.381740717819351 0.30795546546997 0.941342741224751 0.00410378005200245 MirTarget -0.142032683072737 0.00043178257494938 NA NA NA hsa-miR-361-5p IL6 0.21454431962475 0.0800957579368424 -2.77649282936041 1.75717225104248e-11 miRanda -0.437759355067832 0.00687022648152616 NA NA NA hsa-miR-429 IL6 2.3794516574089 1.72813419703734e-13 -2.77649282936041 1.75717225104248e-11 miRanda -0.430343117737244 4.74829761062858e-12 NA NA NA hsa-miR-106a-5p IL6R 1.3902608059488 6.07931522284525e-05 -1.1746226729414 2.27195491770167e-06 mirMAP -0.218074678741591 2.2042752508132e-09 NA NA NA hsa-miR-106b-5p IL6R 1.47447672652218 1.32004094930462e-13 -1.1746226729414 2.27195491770167e-06 mirMAP -0.350202808805077 3.4833398229178e-10 NA NA NA hsa-miR-130a-3p IL6R 0.881660100597014 0.000158893668519248 -1.1746226729414 2.27195491770167e-06 mirMAP -0.155371931802609 0.00162007530132916 NA NA NA hsa-miR-130b-3p IL6R 1.83046548750752 5.04753914574694e-13 -1.1746226729414 2.27195491770167e-06 mirMAP -0.413149194390995 5.14327108475923e-20 NA NA NA hsa-miR-141-3p IL6R 3.36993755486106 5.42939251147195e-32 -1.1746226729414 2.27195491770167e-06 MirTarget -0.113765005170378 0.00249311441364036 NA NA NA hsa-miR-141-5p IL6R 3.02575703771074 1.54385222591327e-32 -1.1746226729414 2.27195491770167e-06 MirTarget -0.116574683527499 0.00584925280444116 NA NA NA hsa-miR-17-5p IL6R 2.07078488653279 2.77403038572568e-19 -1.1746226729414 2.27195491770167e-06 mirMAP -0.244716956140182 2.99341970524535e-07 NA NA NA hsa-miR-193a-3p IL6R 0.549173467360291 0.0319030569365466 -1.1746226729414 2.27195491770167e-06 mirMAP -0.288592318482886 2.36933002614249e-09 NA NA NA hsa-miR-193b-3p IL6R 1.10444771306846 0.000822888533401377 -1.1746226729414 2.27195491770167e-06 mirMAP -0.183254512449137 1.0448823932318e-07 NA NA NA hsa-miR-20a-5p IL6R 2.64649625616975 5.1469418982085e-27 -1.1746226729414 2.27195491770167e-06 mirMAP -0.185356001527945 2.70729728290465e-05 NA NA NA hsa-miR-20b-5p IL6R 1.35770573270947 0.00260808530013016 -1.1746226729414 2.27195491770167e-06 mirMAP -0.156868294348864 3.3112376138858e-09 NA NA NA hsa-miR-21-5p IL6R 4.38165933891779 1.52536633902505e-92 -1.1746226729414 2.27195491770167e-06 MirTarget;miRNATAP -0.198071898371476 5.86460332384805e-06 NA NA NA hsa-miR-22-3p IL6R 1.42501909916631 1.72295005910055e-25 -1.1746226729414 2.27195491770167e-06 MirTarget -0.215724062710191 0.00790869912542495 NA NA NA hsa-miR-301a-3p IL6R 2.70198002906399 1.56420889710984e-14 -1.1746226729414 2.27195491770167e-06 mirMAP -0.194456583370885 7.12633405994253e-07 NA NA NA hsa-miR-320b IL6R 0.226640952564488 0.378818692487242 -1.1746226729414 2.27195491770167e-06 miRanda;miRNATAP -0.183694444376242 4.10299857449601e-05 NA NA NA hsa-miR-33a-5p IL6R 2.80127809675219 5.09053890529424e-12 -1.1746226729414 2.27195491770167e-06 mirMAP -0.165953433237246 1.20456750443638e-06 NA NA NA hsa-miR-421 IL6R 0.170525317701774 0.535277026680289 -1.1746226729414 2.27195491770167e-06 mirMAP -0.260333625187544 8.13554387283894e-09 NA NA NA hsa-miR-454-3p IL6R 1.49453641052169 4.46235742871434e-09 -1.1746226729414 2.27195491770167e-06 mirMAP -0.221062065152908 3.30345689392872e-05 NA NA NA hsa-miR-576-5p IL6R 1.02693643167056 1.14846964470173e-06 -1.1746226729414 2.27195491770167e-06 mirMAP -0.222840698184183 3.80996036993166e-05 NA NA NA hsa-miR-590-3p IL6R 0.83851360565783 0.00129224433453587 -1.1746226729414 2.27195491770167e-06 mirMAP -0.210607261143576 6.80895496632582e-05 NA NA NA hsa-miR-590-5p IL6R 2.07441240363458 4.95240551694843e-14 -1.1746226729414 2.27195491770167e-06 MirTarget;miRNATAP -0.333991322213794 1.89564370294894e-11 NA NA NA hsa-miR-708-3p IL6R 3.43841959417743 4.40027692981683e-28 -1.1746226729414 2.27195491770167e-06 mirMAP -0.24480911276646 1.39639357491191e-10 NA NA NA hsa-miR-93-5p IL6R 1.50844106515467 1.83836866996875e-12 -1.1746226729414 2.27195491770167e-06 mirMAP -0.30062611296742 8.25015656889055e-09 NA NA NA hsa-miR-942-5p IL6R -0.0372813055050076 0.870631058767894 -1.1746226729414 2.27195491770167e-06 MirTarget -0.259354017517313 4.92891498625763e-07 NA NA NA hsa-miR-335-3p IL7 1.51116383169018 6.88553098788624e-13 -0.702514086438196 0.00932145759239818 mirMAP -0.26373886255117 4.63035348071129e-06 NA NA NA hsa-miR-429 IL7 2.3794516574089 1.72813419703734e-13 -0.702514086438196 0.00932145759239818 miRanda -0.129585970599044 0.00145437595310485 NA NA NA hsa-miR-335-3p IL7R 1.51116383169018 6.88553098788624e-13 -2.24247041370452 2.58321797620589e-09 mirMAP -0.38178183644854 2.76716017152587e-06 NA NA NA hsa-miR-450b-5p IL7R 1.69248953402469 1.96052058003353e-07 -2.24247041370452 2.58321797620589e-09 mirMAP -0.240442973288861 5.51469958709109e-05 NA NA NA hsa-miR-501-5p IL7R 0.411357595674671 0.10435288464149 -2.24247041370452 2.58321797620589e-09 mirMAP -0.235161850813912 0.000736985517218325 NA NA NA hsa-miR-576-5p IL7R 1.02693643167056 1.14846964470173e-06 -2.24247041370452 2.58321797620589e-09 mirMAP -0.241502374217978 0.00361035935418838 NA NA NA hsa-miR-7-1-3p IL7R 2.61364240402652 1.98959237815786e-32 -2.24247041370452 2.58321797620589e-09 mirMAP -0.352356221963728 6.81076457228874e-06 NA NA NA hsa-miR-140-3p INSR -1.11373309124537 8.35257079443689e-14 0.072568705841749 0.687422001875906 mirMAP -0.200969274134693 0.000223788161756352 NA NA NA hsa-miR-142-5p INSR 1.29672439149353 4.0768822158894e-06 0.072568705841749 0.687422001875906 mirMAP -0.128826469755798 4.33606154307156e-05 NA NA NA hsa-miR-15a-5p INSR 1.62575353599172 1.55312121019827e-19 0.072568705841749 0.687422001875906 miRNATAP -0.200612762607263 5.63146477400131e-06 NA NA NA hsa-miR-15b-5p INSR -1.25935038177398 1.83460220856901e-12 0.072568705841749 0.687422001875906 miRNATAP -0.175362598837309 0.000110773407928035 NA NA NA hsa-miR-16-5p INSR 0.749619098384047 4.11649450706988e-06 0.072568705841749 0.687422001875906 miRNATAP -0.254218737256182 4.56844501195278e-07 NA NA NA hsa-miR-181a-5p INSR -0.375429731222937 0.0562142867129802 0.072568705841749 0.687422001875906 mirMAP -0.117544426204587 0.00550204397365251 NA NA NA hsa-miR-181b-5p INSR 0.668793269169928 0.000239998092406404 0.072568705841749 0.687422001875906 mirMAP -0.173780381709745 0.000128395961704462 NA NA NA hsa-miR-186-5p INSR 0.852175445703945 6.88885738584309e-10 0.072568705841749 0.687422001875906 mirMAP -0.200951314334329 0.000747227365469451 NA NA NA hsa-miR-30a-3p INSR -2.54042202792785 2.9111625410859e-18 0.072568705841749 0.687422001875906 mirMAP -0.104571944539812 0.000124653355600104 25582198 Role of microRNA 30a targeting insulin receptor substrate 2 in colorectal tumorigenesis; Moreover bioinformatic algorithms and luciferase reporter assays revealed that insulin receptor substrate 2 IRS2 is a direct target of miR-30a tumorigenesis colorectal cancer hsa-miR-30e-3p INSR -0.104420043859122 0.526240453209293 0.072568705841749 0.687422001875906 mirMAP -0.256243498262524 3.55354622595702e-07 NA NA NA hsa-miR-342-3p INSR -0.128691966564961 0.561034080130801 0.072568705841749 0.687422001875906 miRanda -0.189578932203005 3.55828930027543e-07 NA NA NA hsa-miR-361-5p INSR 0.21454431962475 0.0800957579368424 0.072568705841749 0.687422001875906 miRanda -0.224157815213429 0.0011296295717728 NA NA NA hsa-miR-374a-3p INSR 1.73882813668241 1.57901646296214e-13 0.072568705841749 0.687422001875906 mirMAP -0.140068896396232 4.07063958462341e-05 NA NA NA hsa-miR-424-5p INSR 1.26485330287919 6.1498991028257e-06 0.072568705841749 0.687422001875906 miRNATAP -0.145781011286284 5.38557964947113e-07 NA NA NA hsa-miR-590-3p INSR 0.83851360565783 0.00129224433453587 0.072568705841749 0.687422001875906 PITA;miRanda;mirMAP;miRNATAP -0.160616185203576 2.20508605665908e-05 NA NA NA hsa-miR-590-5p INSR 2.07441240363458 4.95240551694843e-14 0.072568705841749 0.687422001875906 mirMAP -0.141781156333303 9.05987480029783e-05 NA NA NA hsa-miR-126-3p IRS1 0.397563736477277 0.115641762947829 0.244610284262608 0.352824876713555 miRNAWalker2_validate;miRTarBase;miRNATAP -0.184891847153225 0.000110947392116251 24312276;23981989;26893720 Down regulation of miR 126 is associated with colorectal cancer cells proliferation migration and invasion by targeting IRS 1 via the AKT and ERK1/2 signaling pathways; In this study we identified the potential effects of miR-126 on some important biological properties of CRC cells and clarified the regulation of insulin receptor substrate 1 IRS-1 and its possible signaling pathway by miR-126; The 3'-untranslated region 3'-UTR of IRS-1 regulated by miR-126 was analyzed by using a dual-luciferase reporter assay; We found that IRS-1 is the functional downstream target of miR-126 by directly targeting the 3'-UTR of IRS-1; Endogenous miR-126 and exogenous miR-126 mimic inhibited IRS-1 expression; Furthermore gain-of-function or loss-of-function studies showed that over-expression of miR-126 down-regulated IRS-1 suppressed AKT and ERK1/2 activation CRC cells proliferation migration invasion and caused cell cycle arrest but had no effect on cell apoptosis; Knockdown of miR-126 promoted these processes in HCT-116 cells and promoted AKT and ERK1/2 activation by up-regulating the expression of the IRS-1 protein; MiR-126 may play roles in regulation of the biological behavior of CRC cells at least in part by targeting IRS-1 via AKT and ERK1/2 signaling pathways;It has been shown that IRS1 SLC75A and TOM1 were the potential target genes of miR-126 in colon cancer;Molecular mechanism investigation established that insulin receptor substrate 1 IRS1 functioned as a direct miR-126 target and its expression was negatively regulated by miR-126 at a post-transcriptional level in the SKOV3 cells; Additionally the overexpression of IRS1 reversed the inhibitory effect of miR-126 overexpression on SKOV3 cell migration and invasion; In conclusion the current study demonstrated that miR-126 inhibited EC cell migration and invasion at least partially through the direct targeting of IRS1 suggesting that miR-126 may aid the treatment of EC metastasis ;;cell migration;metastasis colorectal cancer;colon cancer;endometrial cancer hsa-miR-148a-3p IRS1 2.30885799126944 1.95226081368985e-21 0.244610284262608 0.352824876713555 miRNAWalker2_validate;miRTarBase -0.209838565058674 9.66789602467501e-06 NA NA NA hsa-miR-16-1-3p IRS1 1.50034693398929 6.63958242991125e-10 0.244610284262608 0.352824876713555 MirTarget -0.181979474379783 0.00282070309616073 NA NA NA hsa-miR-17-3p IRS1 1.36706429551147 4.60388403547821e-13 0.244610284262608 0.352824876713555 MirTarget -0.161933846945787 0.00998504684887949 NA NA NA hsa-miR-200c-3p IRS1 0.380533388300368 0.0842181838538353 0.244610284262608 0.352824876713555 miRNATAP -0.278505861101673 3.39054824837283e-07 NA NA NA hsa-miR-203a-3p IRS1 1.06866854356847 0.00389979689199624 0.244610284262608 0.352824876713555 MirTarget -0.102786251725058 0.00157993095193959 NA NA NA hsa-miR-30b-5p IRS1 0.358144314839612 0.138026229059594 0.244610284262608 0.352824876713555 MirTarget -0.175937520554007 0.000452344845600807 NA NA NA hsa-miR-30c-5p IRS1 -0.327319105755825 0.123595832152687 0.244610284262608 0.352824876713555 MirTarget;miRNATAP -0.284737724617331 5.08569282316144e-07 NA NA NA hsa-miR-30e-5p IRS1 1.60414100786743 3.78951090573667e-19 0.244610284262608 0.352824876713555 MirTarget -0.243862370483916 0.000177609152557379 NA NA NA hsa-miR-338-3p IRS1 0.726843067232002 0.0506251324215494 0.244610284262608 0.352824876713555 miRanda -0.12569726819601 0.000103737720113801 NA NA NA hsa-miR-628-5p IRS1 1.06173574237323 4.67541261016756e-06 0.244610284262608 0.352824876713555 miRNATAP -0.182742628677779 0.00326600493540005 NA NA NA hsa-miR-107 ITGA1 0.658676029898313 5.11480446318819e-07 -0.773741524466799 0.000502895577469888 miRanda -0.339053734594553 1.50945489456562e-05 NA NA NA hsa-miR-141-5p ITGA1 3.02575703771074 1.54385222591327e-32 -0.773741524466799 0.000502895577469888 MirTarget -0.143818392193536 0.000125508257846495 NA NA NA hsa-miR-186-5p ITGA1 0.852175445703945 6.88885738584309e-10 -0.773741524466799 0.000502895577469888 mirMAP -0.342449177588133 3.28130459797381e-06 NA NA NA hsa-miR-200a-5p ITGA1 2.26680634475411 1.52168554660094e-17 -0.773741524466799 0.000502895577469888 mirMAP -0.149786040107268 5.57893512362959e-05 NA NA NA hsa-miR-200b-3p ITGA1 1.55157578247391 4.83790020897188e-09 -0.773741524466799 0.000502895577469888 MirTarget -0.150544978014403 7.60094159534922e-05 NA NA NA hsa-miR-200b-5p ITGA1 0.5652412449293 0.0273948420835934 -0.773741524466799 0.000502895577469888 mirMAP -0.148072636124398 0.000220726206327963 NA NA NA hsa-miR-200c-3p ITGA1 0.380533388300368 0.0842181838538353 -0.773741524466799 0.000502895577469888 MirTarget -0.168988088474944 0.000296763714660256 NA NA NA hsa-miR-21-5p ITGA1 4.38165933891779 1.52536633902505e-92 -0.773741524466799 0.000502895577469888 mirMAP -0.113223257366266 0.00383351078993403 NA NA NA hsa-miR-335-3p ITGA1 1.51116383169018 6.88553098788624e-13 -0.773741524466799 0.000502895577469888 mirMAP -0.204538140205175 1.70684376003745e-05 NA NA NA hsa-miR-362-3p ITGA1 0.194097672030785 0.52808475179225 -0.773741524466799 0.000502895577469888 miRanda -0.176037176448142 2.38978389017531e-05 NA NA NA hsa-miR-421 ITGA1 0.170525317701774 0.535277026680289 -0.773741524466799 0.000502895577469888 miRanda -0.167455913424046 3.60412945342365e-05 NA NA NA hsa-miR-429 ITGA1 2.3794516574089 1.72813419703734e-13 -0.773741524466799 0.000502895577469888 MirTarget;miRanda -0.189399712900852 1.14705709827977e-08 NA NA NA hsa-miR-576-5p ITGA1 1.02693643167056 1.14846964470173e-06 -0.773741524466799 0.000502895577469888 mirMAP -0.245971378953573 2.83888079117159e-07 NA NA NA hsa-miR-590-3p ITGA1 0.83851360565783 0.00129224433453587 -0.773741524466799 0.000502895577469888 miRanda;mirMAP -0.197377613282672 2.69208347345244e-05 NA NA NA hsa-miR-590-5p ITGA1 2.07441240363458 4.95240551694843e-14 -0.773741524466799 0.000502895577469888 miRanda;mirMAP -0.303305381882813 6.9928735127008e-12 NA NA NA hsa-miR-664a-3p ITGA1 0.443077463053857 0.0214248925850984 -0.773741524466799 0.000502895577469888 mirMAP -0.156056094080882 0.0036147447207052 NA NA NA hsa-miR-7-1-3p ITGA1 2.61364240402652 1.98959237815786e-32 -0.773741524466799 0.000502895577469888 mirMAP -0.15535603296153 0.000705312957559912 NA NA NA hsa-miR-708-5p ITGA10 3.04047795672813 3.01085192850869e-20 -1.74852949466288 4.70137862221896e-07 MirTarget -0.183170696680591 0.000473054649448971 NA NA NA hsa-miR-29a-3p ITGA11 0.101650412194573 0.573201097011668 2.22977125874329 2.26268683387668e-08 miRNAWalker2_validate;miRTarBase -0.284836010862059 0.00630621340094418 NA NA NA hsa-miR-532-5p ITGA11 0.576620898517708 0.0023245812680956 2.22977125874329 2.26268683387668e-08 miRNATAP -0.488350329225286 6.06614977204944e-07 NA NA NA hsa-miR-107 ITGA2 0.658676029898313 5.11480446318819e-07 0.819741688063703 0.0236624943026744 MirTarget;miRanda;miRNATAP -0.502644654398121 8.06486079324987e-05 NA NA NA hsa-miR-15b-5p ITGA2 -1.25935038177398 1.83460220856901e-12 0.819741688063703 0.0236624943026744 MirTarget;miRNATAP -0.259522539937534 0.00472053640609525 NA NA NA hsa-miR-16-5p ITGA2 0.749619098384047 4.11649450706988e-06 0.819741688063703 0.0236624943026744 miRNAWalker2_validate;MirTarget;miRNATAP -0.332696009737313 0.00116943184349703 NA NA NA hsa-miR-181c-5p ITGA2 0.529875814537156 0.0125885822998008 0.819741688063703 0.0236624943026744 MirTarget -0.240742904253973 0.00225071857367623 NA NA NA hsa-miR-18a-5p ITGA2 1.37435209536521 9.2173853686829e-06 0.819741688063703 0.0236624943026744 MirTarget -0.31380698282467 4.36049857987287e-08 NA NA NA hsa-miR-19a-3p ITGA2 2.11776595911517 7.07663078397156e-10 0.819741688063703 0.0236624943026744 MirTarget -0.24851476927225 1.1825389761636e-05 NA NA NA hsa-miR-19b-3p ITGA2 2.10868505662119 5.40846613768389e-17 0.819741688063703 0.0236624943026744 MirTarget -0.182640436739443 0.00698279331787996 NA NA NA hsa-miR-200c-3p ITGA2 0.380533388300368 0.0842181838538353 0.819741688063703 0.0236624943026744 mirMAP -0.294353925147486 0.000102858547602016 NA NA NA hsa-miR-26b-5p ITGA2 0.72362441215247 4.7794659748036e-05 0.819741688063703 0.0236624943026744 mirMAP -0.320920069895586 0.000615534045551923 NA NA NA hsa-miR-301a-3p ITGA2 2.70198002906399 1.56420889710984e-14 0.819741688063703 0.0236624943026744 mirMAP -0.153279304256606 0.0074017678161524 NA NA NA hsa-miR-30b-5p ITGA2 0.358144314839612 0.138026229059594 0.819741688063703 0.0236624943026744 mirMAP -0.210045070780396 0.00244968994579558 NA NA NA hsa-miR-324-5p ITGA2 1.06955541886548 5.39722006604758e-05 0.819741688063703 0.0236624943026744 miRanda -0.278448235530963 7.85723061021125e-06 NA NA NA hsa-miR-326 ITGA2 -0.992397386750901 0.00335173765975096 0.819741688063703 0.0236624943026744 PITA -0.171387643372051 0.000481235762466123 NA NA NA hsa-miR-335-5p ITGA2 -0.466533891325811 0.0676987038122831 0.819741688063703 0.0236624943026744 miRNAWalker2_validate -0.291383602328256 6.63115253286623e-05 NA NA NA hsa-miR-424-5p ITGA2 1.26485330287919 6.1498991028257e-06 0.819741688063703 0.0236624943026744 MirTarget;miRNATAP -0.205074133694928 0.000518652085598699 NA NA NA hsa-miR-454-3p ITGA2 1.49453641052169 4.46235742871434e-09 0.819741688063703 0.0236624943026744 mirMAP -0.313493615139346 4.68543025043173e-05 NA NA NA hsa-miR-590-3p ITGA2 0.83851360565783 0.00129224433453587 0.819741688063703 0.0236624943026744 MirTarget;miRanda;mirMAP -0.199501454948866 0.00940455912787266 NA NA NA hsa-miR-186-5p ITGA3 0.852175445703945 6.88885738584309e-10 -0.134393569692584 0.619364184326163 miRNATAP -0.337526219224316 0.000158914051275583 NA NA NA hsa-miR-330-5p ITGA3 0.168520831101569 0.336433937906706 -0.134393569692584 0.619364184326163 miRanda -0.322828993909487 5.61851479768124e-06 NA NA NA hsa-miR-940 ITGA3 0.011138136211269 0.974925352379525 -0.134393569692584 0.619364184326163 miRNATAP -0.201784603457958 2.42551698952866e-07 NA NA NA hsa-miR-17-5p ITGA4 2.07078488653279 2.77403038572568e-19 -0.562112934310272 0.0137570428176852 TargetScan -0.284724465767202 3.84025106095607e-11 NA NA NA hsa-miR-320b ITGA4 0.226640952564488 0.378818692487242 -0.562112934310272 0.0137570428176852 miRanda -0.114108252234588 0.00534317315402664 NA NA NA hsa-miR-339-5p ITGA4 0.536997313601114 0.0488090394176611 -0.562112934310272 0.0137570428176852 miRanda -0.10773510241621 0.0052751460891271 NA NA NA hsa-miR-107 ITGA5 0.658676029898313 5.11480446318819e-07 -1.01121491098415 8.84227998350758e-06 PITA;miRanda -0.376426978987928 2.81600962880671e-06 NA NA NA hsa-miR-148a-3p ITGA5 2.30885799126944 1.95226081368985e-21 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.190743856582124 3.98731911985598e-06 NA NA NA hsa-miR-148b-3p ITGA5 0.483970528590224 0.0026495409465901 -1.01121491098415 8.84227998350758e-06 miRNAWalker2_validate -0.243410593466733 0.000219706777932876 27328731 Notably transendothelial migration in vitro and extravasation in vivo impaired by singly alternating miR-214 or miR-148b could be overridden by overexpression of ITGA5 or ALCAM in the same tumor cells melanoma hsa-miR-183-5p ITGA5 2.39247234736657 3.92444525331999e-21 -1.01121491098415 8.84227998350758e-06 miRNAWalker2_validate -0.259399847110325 3.43042872637588e-11 NA NA NA hsa-miR-26a-5p ITGA5 -0.126411409001078 0.440028840408711 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.204698760741648 0.00168812743238086 25537511 Furthermore we provide experimental evidence to confirm that ITGA5 is a bona fide target of miR-26a liver cancer hsa-miR-26b-5p ITGA5 0.72362441215247 4.7794659748036e-05 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.188305584857056 0.00150247485518784 NA NA NA hsa-miR-27b-3p ITGA5 0.236438984240408 0.12263510345883 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.229293190778418 0.00100496421391008 NA NA NA hsa-miR-28-5p ITGA5 1.19639196514745 4.59365801666536e-18 -1.01121491098415 8.84227998350758e-06 PITA;miRanda -0.238760737410615 0.00137547168780412 NA NA NA hsa-miR-3065-3p ITGA5 0.381740717819351 0.30795546546997 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.148579744891363 1.02005735906916e-07 NA NA NA hsa-miR-30c-5p ITGA5 -0.327319105755825 0.123595832152687 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.179563357225459 0.000311329951407395 NA NA NA hsa-miR-30d-5p ITGA5 -0.920901858717441 3.50898334321668e-05 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.38902289960491 1.69778694494792e-17 NA NA NA hsa-miR-32-5p ITGA5 0.876853679269853 6.04859399018691e-05 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.168503633823216 0.00125994595302324 NA NA NA hsa-miR-429 ITGA5 2.3794516574089 1.72813419703734e-13 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.351683208392125 4.59050842531831e-27 NA NA NA hsa-miR-98-5p ITGA5 1.170602085804 1.09900501665229e-08 -1.01121491098415 8.84227998350758e-06 miRNAWalker2_validate -0.194633832346188 0.000192318321358743 NA NA NA hsa-miR-335-3p ITGA6 1.51116383169018 6.88553098788624e-13 -1.09138920476995 0.000240937852791744 mirMAP -0.167394104269303 0.00896905708845126 NA NA NA hsa-miR-34a-5p ITGA6 1.40588612517769 8.60097477768592e-12 -1.09138920476995 0.000240937852791744 miRNAWalker2_validate -0.304514257484638 2.93622647200052e-06 NA NA NA hsa-miR-130b-3p ITGA8 1.83046548750752 5.04753914574694e-13 -3.15124279620377 2.20806819414868e-12 mirMAP -0.802232593330632 1.70820581011839e-22 NA NA NA hsa-miR-16-1-3p ITGA8 1.50034693398929 6.63958242991125e-10 -3.15124279620377 2.20806819414868e-12 mirMAP -0.452066306605377 2.04527574968064e-05 NA NA NA hsa-miR-183-5p ITGA8 2.39247234736657 3.92444525331999e-21 -3.15124279620377 2.20806819414868e-12 miRNAWalker2_validate -0.549653066027182 2.18144720600186e-12 NA NA NA hsa-miR-19b-1-5p ITGA8 1.71217036351784 3.28561659177495e-12 -3.15124279620377 2.20806819414868e-12 mirMAP -0.500196381876525 2.20645795023449e-07 NA NA NA hsa-miR-21-5p ITGA8 4.38165933891779 1.52536633902505e-92 -3.15124279620377 2.20806819414868e-12 mirMAP -0.612096953356325 6.15646517857185e-15 NA NA NA hsa-miR-301a-3p ITGA8 2.70198002906399 1.56420889710984e-14 -3.15124279620377 2.20806819414868e-12 mirMAP -0.477752920315526 1.87663634846344e-11 NA NA NA hsa-miR-335-3p ITGA8 1.51116383169018 6.88553098788624e-13 -3.15124279620377 2.20806819414868e-12 mirMAP -0.490675973469975 5.04048548668169e-07 NA NA NA hsa-miR-33a-5p ITGA8 2.80127809675219 5.09053890529424e-12 -3.15124279620377 2.20806819414868e-12 mirMAP -0.362707606321545 5.94735589687089e-09 NA NA NA hsa-miR-454-3p ITGA8 1.49453641052169 4.46235742871434e-09 -3.15124279620377 2.20806819414868e-12 mirMAP -0.603933549450148 3.91185777410134e-10 NA NA NA hsa-miR-590-5p ITGA8 2.07441240363458 4.95240551694843e-14 -3.15124279620377 2.20806819414868e-12 mirMAP -0.726686285645743 8.33108253833925e-16 NA NA NA hsa-miR-7-1-3p ITGA8 2.61364240402652 1.98959237815786e-32 -3.15124279620377 2.20806819414868e-12 mirMAP -0.541492835255851 6.69426405639844e-09 NA NA NA hsa-miR-141-5p ITGA9 3.02575703771074 1.54385222591327e-32 -1.26835931374769 0.00010826182322474 MirTarget -0.195181331294249 0.00043056185204449 NA NA NA hsa-miR-142-5p ITGA9 1.29672439149353 4.0768822158894e-06 -1.26835931374769 0.00010826182322474 mirMAP -0.168951014397437 0.00359483509333677 NA NA NA hsa-miR-194-5p ITGA9 1.76979641760284 8.2064222072696e-05 -1.26835931374769 0.00010826182322474 miRNAWalker2_validate;miRTarBase -0.158507076858585 1.85475935959352e-06 NA NA NA hsa-miR-20a-3p ITGA9 2.51803599558247 4.92479325298629e-13 -1.26835931374769 0.00010826182322474 mirMAP -0.25595667980668 2.64962657754225e-06 NA NA NA hsa-miR-223-3p ITGA9 -0.51475567451355 0.0609181549839239 -1.26835931374769 0.00010826182322474 mirMAP -0.190990834062024 0.000540945360012346 24333181 Our aim was to investigate miR-223 regulation in HCC miR-223 and integrin αV dysregulation were verified in 57 HCC specimens; Enhanced miR-223 expression had a negative effect on integrin αV-mediated cell migration; Further analysis demonstrated that integrin αV is negatively regulated by miR-223 cell migration liver cancer hsa-miR-29a-5p ITGA9 1.89519956688438 1.03453349363915e-11 -1.26835931374769 0.00010826182322474 mirMAP -0.205205719755718 0.00128254409589383 26903137 We found that the up-regulation of hTERT in gastric cancer cells could inhibit the expression of miR-29a and enhance the expression of Integrin β1 ITGB1 gastric cancer hsa-miR-29b-1-5p ITGA9 1.71024742617744 3.64915691793611e-09 -1.26835931374769 0.00010826182322474 mirMAP -0.169163515570498 0.00100976745258328 NA NA NA hsa-miR-324-5p ITGA9 1.06955541886548 5.39722006604758e-05 -1.26835931374769 0.00010826182322474 miRanda -0.225841619201819 6.92067476058291e-05 NA NA NA hsa-miR-33a-5p ITGA9 2.80127809675219 5.09053890529424e-12 -1.26835931374769 0.00010826182322474 mirMAP -0.21990117478508 9.75513320247838e-07 NA NA NA hsa-miR-421 ITGA9 0.170525317701774 0.535277026680289 -1.26835931374769 0.00010826182322474 mirMAP -0.424545921171816 4.93251893069802e-13 NA NA NA hsa-miR-576-5p ITGA9 1.02693643167056 1.14846964470173e-06 -1.26835931374769 0.00010826182322474 mirMAP -0.574355659173543 1.01528630591302e-16 NA NA NA hsa-miR-589-3p ITGA9 1.34253876396688 1.84935927493927e-05 -1.26835931374769 0.00010826182322474 mirMAP -0.159364986759917 0.00130098058920217 NA NA NA hsa-miR-590-3p ITGA9 0.83851360565783 0.00129224433453587 -1.26835931374769 0.00010826182322474 miRanda -0.455511268200979 2.83539442146924e-11 NA NA NA hsa-miR-590-5p ITGA9 2.07441240363458 4.95240551694843e-14 -1.26835931374769 0.00010826182322474 miRanda -0.562462881812878 2.1900601901318e-18 NA NA NA hsa-miR-186-5p ITGAV 0.852175445703945 6.88885738584309e-10 0.629020501889756 0.00121760194300065 mirMAP -0.250813157407602 0.000100925252185187 NA NA NA hsa-miR-195-3p ITGAV -1.33068822339418 6.65427393047357e-09 0.629020501889756 0.00121760194300065 mirMAP -0.11327382977939 0.00345465236128657 NA NA NA hsa-miR-200a-3p ITGAV 3.14766878548496 1.32850889777422e-21 0.629020501889756 0.00121760194300065 MirTarget -0.127414645651193 1.47196823709712e-06 NA NA NA hsa-miR-25-3p ITGAV 0.361927330834176 0.0163670566170988 0.629020501889756 0.00121760194300065 MirTarget;miRNATAP -0.207835057284429 0.000540572046282237 NA NA NA hsa-miR-32-5p ITGAV 0.876853679269853 6.04859399018691e-05 0.629020501889756 0.00121760194300065 miRNAWalker2_validate;MirTarget;miRNATAP -0.164722332332458 0.000202402491174369 NA NA NA hsa-miR-328-3p ITGAV -0.971820898675371 0.000667255504710486 0.629020501889756 0.00121760194300065 MirTarget -0.127861389315362 4.10469762288386e-05 NA NA NA hsa-miR-429 ITGAV 2.3794516574089 1.72813419703734e-13 0.629020501889756 0.00121760194300065 miRanda -0.131461107413828 6.57884777390413e-06 NA NA NA hsa-miR-92a-3p ITGAV -0.136362762339122 0.493412263619364 0.629020501889756 0.00121760194300065 MirTarget;miRNATAP -0.273385861734189 9.60968012252871e-10 NA NA NA hsa-miR-92b-3p ITGAV 0.0478787637665503 0.831716894621477 0.629020501889756 0.00121760194300065 MirTarget;miRNATAP -0.144437810146408 0.000299309968103135 NA NA NA hsa-miR-140-3p ITGB1 -1.11373309124537 8.35257079443689e-14 -0.0945630286148287 0.525842753551564 PITA -0.152201848271678 0.000723446298763032 NA NA NA hsa-miR-146b-5p ITGB1 1.0922867893808 5.63754607494775e-06 -0.0945630286148287 0.525842753551564 miRanda -0.157715286196658 1.51730634456574e-08 NA NA NA hsa-miR-186-5p ITGB1 0.852175445703945 6.88885738584309e-10 -0.0945630286148287 0.525842753551564 miRNAWalker2_validate -0.201339915376033 4.08520833488966e-05 NA NA NA hsa-miR-195-3p ITGB1 -1.33068822339418 6.65427393047357e-09 -0.0945630286148287 0.525842753551564 mirMAP -0.115798048220866 8.14803984710778e-05 NA NA NA hsa-miR-29a-3p ITGB1 0.101650412194573 0.573201097011668 -0.0945630286148287 0.525842753551564 MirTarget;miRNATAP -0.109878624221877 0.00404808868232385 26903137 hTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA 29a; We found that the up-regulation of hTERT in gastric cancer cells could inhibit the expression of miR-29a and enhance the expression of Integrin β1 ITGB1; Our study also found that the restoration of miR-29a suppressed the expression of ITGB1 and inhibited GC cell metastasis both in vitro and in vivo metastasis gastric cancer hsa-miR-29b-3p ITGB1 3.10527711861309 3.01242507282711e-32 -0.0945630286148287 0.525842753551564 MirTarget;miRNATAP -0.116549490422703 1.30157044170051e-06 NA NA NA hsa-miR-29c-3p ITGB1 1.32354490728858 1.84279305179762e-07 -0.0945630286148287 0.525842753551564 MirTarget;miRNATAP -0.105864442600629 6.62006620541073e-05 26766915 MiR 29c inhibits cell growth invasion and migration of pancreatic cancer by targeting ITGB1; Further analysis revealed that ITGB1 is one of the functional target genes of miR-29c and knockdown of ITGB1 inhibited the proliferation migration and invasion of PC cells which was similar to the effects of overexpression of miR-29c pancreatic cancer hsa-miR-375 ITGB1 0.615547997686534 0.149199273675144 -0.0945630286148287 0.525842753551564 miRNAWalker2_validate -0.10471437250037 2.54613318887339e-11 NA NA NA hsa-miR-429 ITGB1 2.3794516574089 1.72813419703734e-13 -0.0945630286148287 0.525842753551564 miRanda -0.142131431355487 9.65693465390098e-11 NA NA NA hsa-let-7d-5p ITGB3 -0.618145137285851 6.06067642715858e-05 0.0458202617452499 0.901111456910611 MirTarget -0.357227641354438 0.00120516547131415 NA NA NA hsa-miR-185-5p ITGB3 1.14291034858482 2.95777119743491e-13 0.0458202617452499 0.901111456910611 MirTarget -0.352714390889775 0.000910586329741436 NA NA NA hsa-miR-186-5p ITGB3 0.852175445703945 6.88885738584309e-10 0.0458202617452499 0.901111456910611 mirMAP -0.569008403398576 2.74458397428635e-06 NA NA NA hsa-miR-30b-5p ITGB3 0.358144314839612 0.138026229059594 0.0458202617452499 0.901111456910611 mirMAP -0.234134873831798 0.000867560552242133 20498642 Enforced constitutive expression of mir-30 in BT-ICs inhibits their self-renewal capacity by reducing Ubc9 and induces apoptosis through silencing ITGB3 breast cancer hsa-miR-30c-5p ITGB3 -0.327319105755825 0.123595832152687 0.0458202617452499 0.901111456910611 miRNAWalker2_validate;mirMAP;miRNATAP -0.229754484199109 0.00413681088320415 NA NA NA hsa-miR-30d-5p ITGB3 -0.920901858717441 3.50898334321668e-05 0.0458202617452499 0.901111456910611 miRNATAP -0.2370999896332 0.00176139579739907 NA NA NA hsa-miR-320b ITGB3 0.226640952564488 0.378818692487242 0.0458202617452499 0.901111456910611 miRanda -0.202928798542316 0.00210098967988018 NA NA NA hsa-miR-338-3p ITGB3 0.726843067232002 0.0506251324215494 0.0458202617452499 0.901111456910611 miRanda -0.144755795263914 0.00145730847965422 27431198 Furthermore we also identified a metastasis related protein integrin β3 ITGB3 as a novel target gene of miR-338 metastasis lung cancer hsa-miR-425-5p ITGB3 1.21659524959201 8.01126418494715e-09 0.0458202617452499 0.901111456910611 MirTarget -0.336225303608678 2.09149227158485e-05 NA NA NA hsa-miR-429 ITGB3 2.3794516574089 1.72813419703734e-13 0.0458202617452499 0.901111456910611 miRanda -0.208336534572015 0.000162930117373071 NA NA NA hsa-miR-590-5p ITGB3 2.07441240363458 4.95240551694843e-14 0.0458202617452499 0.901111456910611 miRanda -0.305496818831574 3.74015409256109e-05 NA NA NA hsa-miR-16-5p ITGB4 0.749619098384047 4.11649450706988e-06 0.895169889709774 0.0139079049309048 miRNAWalker2_validate -0.283852854927185 0.00593336832805821 NA NA NA hsa-miR-335-5p ITGB4 -0.466533891325811 0.0676987038122831 0.895169889709774 0.0139079049309048 miRNAWalker2_validate -0.384849163419261 1.32234316724742e-07 NA NA NA hsa-miR-335-5p ITGB5 -0.466533891325811 0.0676987038122831 0.0914403769390919 0.565322367903286 miRNAWalker2_validate -0.186953458336436 3.26260715161371e-09 NA NA NA hsa-miR-17-5p ITGB6 2.07078488653279 2.77403038572568e-19 -0.719575844641635 0.0293950395210202 TargetScan -0.377101017178564 1.70930689649643e-09 NA NA NA hsa-miR-197-3p ITGB6 -1.2979654860824 1.79649132641813e-07 -0.719575844641635 0.0293950395210202 MirTarget -0.201485066094732 0.000862498090498853 NA NA NA hsa-miR-590-3p ITGB6 0.83851360565783 0.00129224433453587 -0.719575844641635 0.0293950395210202 mirMAP -0.277669854784437 6.7586329424938e-05 NA NA NA hsa-miR-629-5p ITGB6 1.31657090341737 1.45711558652127e-12 -0.719575844641635 0.0293950395210202 MirTarget -0.597399959319128 2.27164028732747e-14 NA NA NA hsa-miR-7-1-3p ITGB6 2.61364240402652 1.98959237815786e-32 -0.719575844641635 0.0293950395210202 MirTarget -0.215774090643475 0.001498514780313 NA NA NA hsa-miR-107 ITGB7 0.658676029898313 5.11480446318819e-07 0.217197379531827 0.346903601027026 miRanda -0.275044008363256 0.000704879333910886 NA NA NA hsa-miR-125a-3p ITGB7 -1.04954492275266 2.45974219476832e-06 0.217197379531827 0.346903601027026 miRanda -0.159185309347513 0.000753240438490191 NA NA NA hsa-miR-141-3p ITGB8 3.36993755486106 5.42939251147195e-32 0.341890702062936 0.460134385864712 MirTarget -0.249295650052307 0.000314149629846542 NA NA NA hsa-miR-148a-3p ITGB8 2.30885799126944 1.95226081368985e-21 0.341890702062936 0.460134385864712 miRNATAP -0.218409914556892 0.00931658471965536 NA NA NA hsa-miR-17-5p ITGB8 2.07078488653279 2.77403038572568e-19 0.341890702062936 0.460134385864712 MirTarget;TargetScan;miRNATAP -0.431496474007788 9.7548118685605e-07 NA NA NA hsa-miR-19a-3p ITGB8 2.11776595911517 7.07663078397156e-10 0.341890702062936 0.460134385864712 MirTarget -0.289455226924768 6.44296749606719e-05 NA NA NA hsa-miR-19b-1-5p ITGB8 1.71217036351784 3.28561659177495e-12 0.341890702062936 0.460134385864712 miRNAWalker2_validate -0.472856569859628 1.14317804665996e-06 NA NA NA hsa-miR-19b-3p ITGB8 2.10868505662119 5.40846613768389e-17 0.341890702062936 0.460134385864712 MirTarget -0.357375731680447 3.13737273660658e-05 NA NA NA hsa-miR-20a-5p ITGB8 2.64649625616975 5.1469418982085e-27 0.341890702062936 0.460134385864712 MirTarget;miRNATAP -0.39003113382542 1.54017066893349e-06 NA NA NA hsa-miR-26b-5p ITGB8 0.72362441215247 4.7794659748036e-05 0.341890702062936 0.460134385864712 MirTarget -0.388588230345951 0.00114958540405258 NA NA NA hsa-miR-330-5p ITGB8 0.168520831101569 0.336433937906706 0.341890702062936 0.460134385864712 MirTarget;miRanda;miRNATAP -0.560754864766575 4.07438971878398e-06 NA NA NA hsa-miR-335-5p ITGB8 -0.466533891325811 0.0676987038122831 0.341890702062936 0.460134385864712 miRNAWalker2_validate -0.436456274299298 2.56334828164261e-06 NA NA NA hsa-miR-338-3p ITGB8 0.726843067232002 0.0506251324215494 0.341890702062936 0.460134385864712 miRanda -0.286268802644821 4.33113259670687e-07 NA NA NA hsa-miR-576-5p ITGB8 1.02693643167056 1.14846964470173e-06 0.341890702062936 0.460134385864712 PITA -0.266161191308081 0.00792335735499053 NA NA NA hsa-miR-582-5p ITGB8 1.08286181406653 0.00149040450161757 0.341890702062936 0.460134385864712 miRNATAP -0.324822171428819 2.74569673820179e-07 NA NA NA hsa-let-7g-3p JAK1 2.38336858943031 4.8771148585792e-17 -0.603898351740195 2.60299135232136e-07 MirTarget -0.109925124338959 1.65988376328151e-09 NA NA NA hsa-miR-106a-5p JAK1 1.3902608059488 6.07931522284525e-05 -0.603898351740195 2.60299135232136e-07 MirTarget -0.109787666786419 1.46945811917045e-10 NA NA NA hsa-miR-106b-5p JAK1 1.47447672652218 1.32004094930462e-13 -0.603898351740195 2.60299135232136e-07 miRNAWalker2_validate;MirTarget -0.199500375609548 1.80265958380738e-14 NA NA NA hsa-miR-128-3p JAK1 1.03509868349735 2.11606310588315e-10 -0.603898351740195 2.60299135232136e-07 miRNAWalker2_validate -0.159074099467127 1.23753139998692e-06 NA NA NA hsa-miR-17-5p JAK1 2.07078488653279 2.77403038572568e-19 -0.603898351740195 2.60299135232136e-07 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.20376007792571 8.88259339183568e-21 NA NA NA hsa-miR-20a-5p JAK1 2.64649625616975 5.1469418982085e-27 -0.603898351740195 2.60299135232136e-07 MirTarget -0.166035806154834 2.64870349477136e-16 NA NA NA hsa-miR-28-5p JAK1 1.19639196514745 4.59365801666536e-18 -0.603898351740195 2.60299135232136e-07 miRanda;miRNATAP -0.133759278277294 0.000497874854510592 NA NA NA hsa-miR-30b-5p JAK1 0.358144314839612 0.138026229059594 -0.603898351740195 2.60299135232136e-07 MirTarget -0.104673840168908 3.1208747081459e-06 NA NA NA hsa-miR-93-5p JAK1 1.50844106515467 1.83836866996875e-12 -0.603898351740195 2.60299135232136e-07 MirTarget;miRNATAP -0.206636582524429 8.9103689814827e-18 NA NA NA hsa-miR-181b-5p JAK2 0.668793269169928 0.000239998092406404 -0.905723361849239 1.08163009019368e-06 mirMAP -0.169203053791489 0.000355371075025635 NA NA NA hsa-miR-30b-3p JAK3 -1.20976737190106 2.63726511331003e-06 1.23261172398308 7.71882332097229e-09 MirTarget -0.13898568928562 0.000291464520270781 NA NA NA hsa-miR-335-5p JAK3 -0.466533891325811 0.0676987038122831 1.23261172398308 7.71882332097229e-09 miRNAWalker2_validate -0.179222820625557 3.98036017298197e-05 NA NA NA hsa-miR-15a-5p KDR 1.62575353599172 1.55312121019827e-19 -1.29217133319599 5.17137540720335e-06 miRNATAP -0.277469551547698 8.30946725476635e-05 NA NA NA hsa-miR-16-5p KDR 0.749619098384047 4.11649450706988e-06 -1.29217133319599 5.17137540720335e-06 miRTarBase;miRNATAP -0.302391399126077 0.000178613946334273 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2 colorectal cancer hsa-miR-19b-1-5p KDR 1.71217036351784 3.28561659177495e-12 -1.29217133319599 5.17137540720335e-06 miRNAWalker2_validate -0.215943064538471 0.000357453344573502 NA NA NA hsa-miR-200c-3p KDR 0.380533388300368 0.0842181838538353 -1.29217133319599 5.17137540720335e-06 miRNATAP -0.266060212567765 8.13005514869735e-06 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-429 KDR 2.3794516574089 1.72813419703734e-13 -1.29217133319599 5.17137540720335e-06 PITA;miRanda;miRNATAP -0.111419145999383 0.00975571919411248 NA NA NA hsa-miR-590-3p KDR 0.83851360565783 0.00129224433453587 -1.29217133319599 5.17137540720335e-06 miRanda -0.242141052927696 5.91937848623311e-05 NA NA NA hsa-miR-590-5p KDR 2.07441240363458 4.95240551694843e-14 -1.29217133319599 5.17137540720335e-06 miRanda -0.245958719964099 1.91688320565153e-05 NA NA NA hsa-miR-142-5p KIT 1.29672439149353 4.0768822158894e-06 -0.670683951943938 0.13028904543406 PITA;miRNATAP -0.267920547512676 0.000579634804390746 NA NA NA hsa-miR-146b-5p KIT 1.0922867893808 5.63754607494775e-06 -0.670683951943938 0.13028904543406 miRNAWalker2_validate -0.403199974103019 1.39869069166224e-06 NA NA NA hsa-miR-193a-3p KIT 0.549173467360291 0.0319030569365466 -0.670683951943938 0.13028904543406 MirTarget;PITA;miRanda;miRNATAP -0.59184224535654 2.97374812152241e-12 NA NA NA hsa-miR-205-5p KIT 1.45372157280932 0.0361802982284339 -0.670683951943938 0.13028904543406 miRNATAP -0.112713698569041 0.000113293586471105 NA NA NA hsa-miR-221-3p KIT -0.0986794612964683 0.654454148658401 -0.670683951943938 0.13028904543406 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.885086313819054 1.85865395223136e-23 NA NA NA hsa-miR-222-3p KIT 0.0327210697409583 0.881937768109611 -0.670683951943938 0.13028904543406 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.889501207966653 1.1576183436693e-23 NA NA NA hsa-miR-34a-5p KIT 1.40588612517769 8.60097477768592e-12 -0.670683951943938 0.13028904543406 MirTarget -0.262099438612708 0.00709787631839905 NA NA NA hsa-miR-34c-5p KIT -1.00125440032112 0.0724432896090357 -0.670683951943938 0.13028904543406 MirTarget;miRanda -0.139621200199509 0.000276467908620036 NA NA NA hsa-miR-450b-5p KIT 1.69248953402469 1.96052058003353e-07 -0.670683951943938 0.13028904543406 MirTarget -0.290374682881939 2.52526370242336e-05 NA NA NA hsa-miR-185-5p KITLG 1.14291034858482 2.95777119743491e-13 -0.407275826421595 0.0946876733686214 miRNAWalker2_validate -0.225593244321958 0.00134638214857205 NA NA NA hsa-miR-186-5p KITLG 0.852175445703945 6.88885738584309e-10 -0.407275826421595 0.0946876733686214 mirMAP -0.285225701747334 0.00040690121762201 NA NA NA hsa-miR-19a-3p KITLG 2.11776595911517 7.07663078397156e-10 -0.407275826421595 0.0946876733686214 mirMAP -0.179513041617669 2.34814882455816e-06 NA NA NA hsa-miR-19b-3p KITLG 2.10868505662119 5.40846613768389e-17 -0.407275826421595 0.0946876733686214 mirMAP -0.166422952440393 0.000239418829583062 NA NA NA hsa-miR-22-5p KITLG 1.71436244278242 9.85038001236064e-15 -0.407275826421595 0.0946876733686214 MirTarget -0.268500442622934 3.5911841394099e-08 NA NA NA hsa-miR-222-3p KITLG 0.0327210697409583 0.881937768109611 -0.407275826421595 0.0946876733686214 miRNAWalker2_validate -0.167620175262976 0.00103681141128354 NA NA NA hsa-miR-26b-5p KITLG 0.72362441215247 4.7794659748036e-05 -0.407275826421595 0.0946876733686214 mirMAP -0.221906119294713 0.00041815365420821 NA NA NA hsa-miR-320b KITLG 0.226640952564488 0.378818692487242 -0.407275826421595 0.0946876733686214 MirTarget;PITA;miRanda -0.147496807582738 0.0007165511642918 NA NA NA hsa-miR-345-5p KITLG 1.48924745604581 1.54134850666509e-06 -0.407275826421595 0.0946876733686214 MirTarget -0.139326030301378 9.39386393271972e-05 NA NA NA hsa-miR-374b-5p KITLG 0.474691035780475 0.0109217471394203 -0.407275826421595 0.0946876733686214 mirMAP -0.210152527144486 0.000962913430509178 NA NA NA hsa-miR-589-3p KITLG 1.34253876396688 1.84935927493927e-05 -0.407275826421595 0.0946876733686214 mirMAP -0.125477431701804 0.000602721030582728 NA NA NA hsa-miR-590-3p KITLG 0.83851360565783 0.00129224433453587 -0.407275826421595 0.0946876733686214 MirTarget;PITA;miRanda -0.197006393084599 0.000125114698530626 NA NA NA hsa-miR-7-1-3p KITLG 2.61364240402652 1.98959237815786e-32 -0.407275826421595 0.0946876733686214 mirMAP -0.210573081033874 2.39872381914342e-05 NA NA NA hsa-miR-9-5p KITLG 4.99250901331516 2.59132733422801e-19 -0.407275826421595 0.0946876733686214 MirTarget -0.107182895596496 1.97865014789599e-08 NA NA NA hsa-let-7a-3p KRAS 0.167285443861993 0.431834813181487 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.165605931792738 5.41329968030116e-05 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-let-7b-3p KRAS -1.81889978084306 6.9913416210266e-19 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.21045052897075 5.92266664846517e-09 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;26581910;22584434;26516699;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS;Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA;Interestingly the differential expression of miRNA in mice also corroborated with the miRNA expression in human PC cell lines and tissue samples; ectopic expression of Let-7b in CD18/HPAF and Capan1 cells resulted in the downregulation of KRAS and MSST1 expression;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;;;; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;pancreatic cancer;lung squamous cell cancer hsa-miR-1-3p KRAS -1.48412019995919 0.000242034342580425 0.538115716643554 0.00142410994615815 MirTarget -0.1135101654678 3.65182035802432e-08 NA NA NA hsa-miR-126-3p KRAS 0.397563736477277 0.115641762947829 0.538115716643554 0.00142410994615815 miRNAWalker2_validate;miRTarBase -0.140662247102959 4.48695871977096e-06 22845403 miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK pancreatic cancer hsa-miR-1271-5p KRAS -0.0172769786790662 0.951102370899887 0.538115716643554 0.00142410994615815 MirTarget -0.111352851066065 6.81606802337118e-05 NA NA NA hsa-miR-140-3p KRAS -1.11373309124537 8.35257079443689e-14 0.538115716643554 0.00142410994615815 MirTarget -0.379051955627805 3.51513569284386e-14 NA NA NA hsa-miR-155-5p KRAS 0.813513839059142 0.000608282725633232 0.538115716643554 0.00142410994615815 miRNAWalker2_validate;miRNATAP -0.136672576377435 2.71388112053399e-05 NA NA NA hsa-miR-16-1-3p KRAS 1.50034693398929 6.63958242991125e-10 0.538115716643554 0.00142410994615815 mirMAP -0.120692099076156 0.0020633534672843 NA NA NA hsa-miR-181a-5p KRAS -0.375429731222937 0.0562142867129802 0.538115716643554 0.00142410994615815 miRNAWalker2_validate -0.232892392323763 2.90389285591447e-09 24098024;27517749;26124189 The KRAS mutational status was determined by pyrosequencing and miR-181a expression was measured by quantitative RT-PCR in CRC tumour tissue and corresponding non-neoplastic colon tissue;Here we report that miR-181a directly binds to 3'-untranslated regions UTRs; downregulates KRAS NRAS and MAPK1; and decreases AML growth; The delivery of miR-181a mimics to target AML cells using transferrin-targeting lipopolyplex nanoparticles NP increased mature miR-181a; downregulated KRAS NRAS and MAPK1; and resulted in decreased phosphorylation of the downstream RAS effectors;MiR 181a 5p inhibits cell proliferation and migration by targeting Kras in non small cell lung cancer A549 cells; Luciferase activity assay results demonstrated that two binding sites of Kras could be directly targeted by miR-181a-5p; Furthermore Kras was down-regulated by miR-181a-5p at both transcriptional and translational levels; SiRNA-mediated Kras down-regulation could mimic the effects of miR-181a-5p mimic in A549 cells; Our findings suggest that miR-181a-5p plays a potential role in tumor suppression by partially targeting Kras and has the potential therapeutic application in NSCLC patients ;; colorectal cancer;acute myeloid leukemia;lung squamous cell cancer hsa-miR-181c-5p KRAS 0.529875814537156 0.0125885822998008 0.538115716643554 0.00142410994615815 miRNAWalker2_validate;miRTarBase -0.113481461651682 0.00199940913466899 NA NA NA hsa-miR-186-5p KRAS 0.852175445703945 6.88885738584309e-10 0.538115716643554 0.00142410994615815 mirMAP -0.173206213582145 0.0020136892983084 NA NA NA hsa-miR-193a-3p KRAS 0.549173467360291 0.0319030569365466 0.538115716643554 0.00142410994615815 MirTarget;miRanda;miRNATAP -0.114033878061734 0.000545245334645599 NA NA NA hsa-miR-193a-5p KRAS -1.15938257046946 2.61709321247277e-08 0.538115716643554 0.00142410994615815 miRNATAP -0.136206451672479 0.000220728848496 NA NA NA hsa-miR-195-3p KRAS -1.33068822339418 6.65427393047357e-09 0.538115716643554 0.00142410994615815 mirMAP -0.26052009331858 1.37547972270525e-15 NA NA NA hsa-miR-199a-5p KRAS 1.3057193856884 2.38429382751645e-08 0.538115716643554 0.00142410994615815 miRanda;miRNATAP -0.190569403157002 4.12804905993219e-09 NA NA NA hsa-miR-199b-5p KRAS 2.13822205171062 4.56262988762436e-15 0.538115716643554 0.00142410994615815 miRanda;miRNATAP -0.160083363830103 4.62674745647173e-09 27517624 The miR-199b prognostic impact was particularly evident in both younger and KRAS wild-type subgroups colorectal cancer hsa-miR-224-3p KRAS 0.921090817288022 0.010010047721564 0.538115716643554 0.00142410994615815 mirMAP -0.11580794239374 2.34601235413632e-07 25919696 MicroRNA 224 is associated with colorectal cancer progression and response to 5 fluorouracil based chemotherapy by KRAS dependent and independent mechanisms; MicroRNA-224 was differentially expressed in dysplastic colorectal disease and in isogeneic KRAS WT and mutant HCT116 cells; 5-FU chemosensitivity was significantly increased in miR-224 knockdown cells and in NIH3T3 cells expressing KRAS and BRAF mutant proteins progression;drug resistance colorectal cancer hsa-miR-27b-3p KRAS 0.236438984240408 0.12263510345883 0.538115716643554 0.00142410994615815 miRNATAP -0.140671332847896 0.00626162133896643 NA NA NA hsa-miR-30a-3p KRAS -2.54042202792785 2.9111625410859e-18 0.538115716643554 0.00142410994615815 MirTarget;miRNATAP -0.122460927678546 1.58218389307393e-06 NA NA NA hsa-miR-30a-5p KRAS -0.924084264430689 0.000762030454634728 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.160923145065632 7.88859261457886e-09 NA NA NA hsa-miR-30b-5p KRAS 0.358144314839612 0.138026229059594 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.147252408030935 4.51771159246383e-06 NA NA NA hsa-miR-30c-5p KRAS -0.327319105755825 0.123595832152687 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.303491851342304 1.38338910293015e-17 22701724 Deregulated miRNAs in hereditary breast cancer revealed a role for miR 30c in regulating KRAS oncogene; In particular we experimentally validated KRAS as a miR-30c target; Luciferase assays confirmed that miR-30c binds the 3'UTR of KRAS transcripts and expression of pre-miR-30c down-regulated KRAS mRNA and protein; In addition we provide evidence that KRAS is a target of miR-30c and that this miRNA suppresses breast cancer cell growth potentially through inhibition of KRAS signaling breast cancer hsa-miR-30d-3p KRAS 0.00396376345349925 0.986457040013182 0.538115716643554 0.00142410994615815 MirTarget;miRNATAP -0.12073831042602 0.00128170411687249 NA NA NA hsa-miR-30d-5p KRAS -0.920901858717441 3.50898334321668e-05 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.124035278299491 0.000357846902820112 NA NA NA hsa-miR-30e-3p KRAS -0.104420043859122 0.526240453209293 0.538115716643554 0.00142410994615815 MirTarget -0.254543853548427 7.09600327106139e-08 NA NA NA hsa-miR-30e-5p KRAS 1.60414100786743 3.78951090573667e-19 0.538115716643554 0.00142410994615815 mirMAP;miRNATAP -0.125942634043968 0.00267795482717309 NA NA NA hsa-miR-501-3p KRAS -0.0405952693028064 0.866802243505833 0.538115716643554 0.00142410994615815 MirTarget;PITA;TargetScan;miRNATAP -0.124338029852589 0.000111299015637681 NA NA NA hsa-miR-502-3p KRAS -0.262270070977708 0.161760375279961 0.538115716643554 0.00142410994615815 MirTarget;PITA;miRNATAP -0.116432061546502 0.00538025775498572 NA NA NA hsa-miR-532-5p KRAS 0.576620898517708 0.0023245812680956 0.538115716643554 0.00142410994615815 MirTarget;PITA;miRNATAP -0.123485597460216 0.00273306142385404 NA NA NA hsa-miR-542-3p LAMA2 1.62226640768239 2.6427102465476e-10 -1.33151497975485 1.22646297955714e-06 miRanda -0.138780904391796 0.00451509326464665 NA NA NA hsa-miR-590-3p LAMA2 0.83851360565783 0.00129224433453587 -1.33151497975485 1.22646297955714e-06 miRanda -0.360214388029535 4.44606430582782e-10 NA NA NA hsa-miR-17-5p LAMA3 2.07078488653279 2.77403038572568e-19 -2.10170523801193 1.03016004869603e-05 TargetScan -0.250971115908008 0.00663400056402506 NA NA NA hsa-miR-21-5p LAMA4 4.38165933891779 1.52536633902505e-92 -1.307569595124 1.13096764436653e-09 MirTarget -0.182825765991897 1.50535502445258e-06 NA NA NA hsa-miR-429 LAMA4 2.3794516574089 1.72813419703734e-13 -1.307569595124 1.13096764436653e-09 miRanda -0.253653816560146 2.02448671221386e-15 NA NA NA hsa-miR-590-3p LAMA4 0.83851360565783 0.00129224433453587 -1.307569595124 1.13096764436653e-09 miRanda -0.177308323998978 0.000118507719275317 NA NA NA hsa-miR-590-5p LAMA4 2.07441240363458 4.95240551694843e-14 -1.307569595124 1.13096764436653e-09 MirTarget;miRanda -0.212178225866172 1.27807105814848e-06 NA NA NA hsa-miR-93-3p LAMA4 1.07631808403007 1.63747525692813e-05 -1.307569595124 1.13096764436653e-09 miRNAWalker2_validate -0.167435087249298 2.61288840636044e-05 NA NA NA hsa-miR-335-5p LAMA5 -0.466533891325811 0.0676987038122831 0.0438514684517699 0.853848931727645 miRNAWalker2_validate -0.177535037027737 0.000209398157250051 NA NA NA hsa-miR-16-5p LAMB1 0.749619098384047 4.11649450706988e-06 -0.575813191835882 0.00496768662503512 miRNAWalker2_validate -0.244623247996028 2.2979042389839e-05 NA NA NA hsa-miR-335-5p LAMB1 -0.466533891325811 0.0676987038122831 -0.575813191835882 0.00496768662503512 miRNAWalker2_validate -0.131784946841122 0.0014841589176118 NA NA NA hsa-miR-375 LAMB1 0.615547997686534 0.149199273675144 -0.575813191835882 0.00496768662503512 miRanda -0.171281667179131 1.56724064917695e-15 NA NA NA hsa-miR-16-5p LAMB3 0.749619098384047 4.11649450706988e-06 0.471498489772865 0.162074139690299 miRNAWalker2_validate -0.248716947851821 0.00914395779954672 NA NA NA hsa-miR-362-3p LAMB3 0.194097672030785 0.52808475179225 0.471498489772865 0.162074139690299 MirTarget;miRanda -0.230923048845824 0.000249055129310048 NA NA NA hsa-miR-484 LAMB3 -0.228576985124486 0.244112867390855 0.471498489772865 0.162074139690299 MirTarget;miRNATAP -0.212225721481866 0.00770632377393587 NA NA NA hsa-miR-146b-5p LAMC1 1.0922867893808 5.63754607494775e-06 -0.110787086889143 0.490508859847474 miRanda -0.157155518419593 1.82576679330076e-07 NA NA NA hsa-miR-15a-5p LAMC1 1.62575353599172 1.55312121019827e-19 -0.110787086889143 0.490508859847474 MirTarget -0.190138810277497 1.30631412770968e-06 NA NA NA hsa-miR-200b-3p LAMC1 1.55157578247391 4.83790020897188e-09 -0.110787086889143 0.490508859847474 MirTarget;TargetScan -0.105419600597403 0.000112500689688591 NA NA NA hsa-miR-29a-3p LAMC1 0.101650412194573 0.573201097011668 -0.110787086889143 0.490508859847474 MirTarget;miRNATAP -0.132455277091454 0.00129663761462845 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29b-3p LAMC1 3.10527711861309 3.01242507282711e-32 -0.110787086889143 0.490508859847474 MirTarget;miRNATAP -0.144783511342865 2.16330017197383e-08 NA NA NA hsa-miR-429 LAMC1 2.3794516574089 1.72813419703734e-13 -0.110787086889143 0.490508859847474 MirTarget;PITA;miRanda;miRNATAP -0.105179895117571 1.14146615944986e-05 NA NA NA hsa-miR-642a-5p LAMC1 0.788077674970441 0.0303202946051994 -0.110787086889143 0.490508859847474 MirTarget -0.101886169635082 7.79484143348306e-07 NA NA NA hsa-miR-148b-3p LAMC2 0.483970528590224 0.0026495409465901 -0.106160755851652 0.773201990515692 miRNAWalker2_validate -0.531031363320226 4.18007243804894e-07 NA NA NA hsa-miR-375 LAMC2 0.615547997686534 0.149199273675144 -0.106160755851652 0.773201990515692 miRanda -0.352593273467605 1.92048173866575e-20 NA NA NA hsa-miR-660-5p LAMC2 2.04875198906126 1.08269480928897e-17 -0.106160755851652 0.773201990515692 MirTarget -0.268942936723928 0.000120478466718749 NA NA NA hsa-miR-130b-3p LAMC3 1.83046548750752 5.04753914574694e-13 -2.14698353199059 2.27873718936343e-10 mirMAP -0.346927138544631 5.57205769365275e-08 NA NA NA hsa-miR-301a-3p LAMC3 2.70198002906399 1.56420889710984e-14 -2.14698353199059 2.27873718936343e-10 mirMAP -0.150669044390356 0.00567190379541399 NA NA NA hsa-miR-425-5p LAMC3 1.21659524959201 8.01126418494715e-09 -2.14698353199059 2.27873718936343e-10 mirMAP -0.221276466530347 0.00296769262201827 NA NA NA hsa-miR-335-3p LPAR1 1.51116383169018 6.88553098788624e-13 -0.380817557241977 0.152464522041785 mirMAP -0.306586628333355 5.1825997645643e-08 NA NA NA hsa-miR-361-5p LPAR1 0.21454431962475 0.0800957579368424 -0.380817557241977 0.152464522041785 miRanda -0.268884318308582 0.00838608091157387 NA NA NA hsa-miR-429 LPAR1 2.3794516574089 1.72813419703734e-13 -0.380817557241977 0.152464522041785 MirTarget;miRanda;miRNATAP -0.112963698960413 0.00478131363648299 NA NA NA hsa-miR-501-5p LPAR1 0.411357595674671 0.10435288464149 -0.380817557241977 0.152464522041785 MirTarget;miRNATAP -0.149168083230497 0.00206010188196908 NA NA NA hsa-miR-143-3p LPAR2 -1.21021691908494 5.70938667332876e-06 1.02869270199093 4.67622743959594e-12 miRNATAP -0.149734441050202 5.43925579085982e-09 NA NA NA hsa-miR-30c-5p MAP2K1 -0.327319105755825 0.123595832152687 -0.126507255559492 0.255813608366235 miRNAWalker2_validate -0.148243346155614 3.94199903529302e-10 NA NA NA hsa-miR-497-5p MAP2K1 -0.0546347378264729 0.786205564901684 -0.126507255559492 0.255813608366235 miRNAWalker2_validate -0.146950542279665 4.9483059880063e-09 NA NA NA hsa-miR-130a-3p MAPK1 0.881660100597014 0.000158893668519248 -0.313704159534906 0.0065740365500908 mirMAP -0.101872197195 5.97373126035408e-06 NA NA NA hsa-miR-140-5p MAPK1 0.669142684153918 0.000335928403032308 -0.313704159534906 0.0065740365500908 miRanda -0.105360739553965 0.000299450445528468 NA NA NA hsa-miR-148a-3p MAPK1 2.30885799126944 1.95226081368985e-21 -0.313704159534906 0.0065740365500908 mirMAP -0.102558880400122 7.51166113357563e-07 NA NA NA hsa-miR-24-1-5p MAPK1 0.856025727237819 0.000107354490323658 -0.313704159534906 0.0065740365500908 mirMAP -0.114103342147363 5.37066958548902e-06 NA NA NA hsa-miR-29a-5p MAPK1 1.89519956688438 1.03453349363915e-11 -0.313704159534906 0.0065740365500908 mirMAP -0.100646824836984 5.49015969248301e-06 NA NA NA hsa-miR-29b-3p MAPK1 3.10527711861309 3.01242507282711e-32 -0.313704159534906 0.0065740365500908 mirMAP -0.122356815748067 3.56933939779318e-11 NA NA NA hsa-miR-342-3p MAPK1 -0.128691966564961 0.561034080130801 -0.313704159534906 0.0065740365500908 miRanda;mirMAP -0.137175460423021 7.76879946497687e-09 NA NA NA hsa-miR-34a-5p MAPK1 1.40588612517769 8.60097477768592e-12 -0.313704159534906 0.0065740365500908 mirMAP -0.105828142272272 2.59913448288353e-05 NA NA NA hsa-miR-454-3p MAPK1 1.49453641052169 4.46235742871434e-09 -0.313704159534906 0.0065740365500908 mirMAP -0.104171229052281 2.01455003951624e-05 NA NA NA hsa-miR-450a-5p MDM2 1.94284269183615 1.52883075909271e-07 -0.018010582169941 0.916081437185101 mirMAP -0.108762560851161 1.20807844291087e-05 NA NA NA hsa-miR-484 MDM2 -0.228576985124486 0.244112867390855 -0.018010582169941 0.916081437185101 miRNAWalker2_validate -0.108672488962364 0.0069392239747807 NA NA NA hsa-miR-30d-3p MET 0.00396376345349925 0.986457040013182 0.183477493526328 0.659377403748523 mirMAP -0.370227369375165 5.63086912296213e-05 NA NA NA hsa-miR-324-5p MET 1.06955541886548 5.39722006604758e-05 0.183477493526328 0.659377403748523 miRanda -0.352488833333601 7.48796940482076e-07 NA NA NA hsa-miR-664a-3p MET 0.443077463053857 0.0214248925850984 0.183477493526328 0.659377403748523 mirMAP -0.324625189996636 0.00113329920907825 NA NA NA hsa-miR-125a-3p MTCP1 -1.04954492275266 2.45974219476832e-06 0.228508601690999 0.199586758436972 PITA;miRanda;miRNATAP -0.106533998535439 0.00350242518700043 NA NA NA hsa-miR-193b-3p MYB 1.10444771306846 0.000822888533401377 -0.490317224753365 0.0968283089994286 miRNAWalker2_validate -0.127451758061739 0.00185135444311072 NA NA NA hsa-miR-542-3p MYB 1.62226640768239 2.6427102465476e-10 -0.490317224753365 0.0968283089994286 miRanda -0.136350179533947 0.00879289943307743 NA NA NA hsa-miR-34a-5p MYC 1.40588612517769 8.60097477768592e-12 -0.594211476201249 0.0196490384548933 miRNAWalker2_validate;miRTarBase -0.160523406918217 0.0041257772904121 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 2.3794516574089 1.72813419703734e-13 -0.594211476201249 0.0196490384548933 miRNAWalker2_validate -0.178099724014789 2.94573429210347e-06 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-671-5p NFKB1 2.24156654191798 2.10433241567652e-14 -0.340270335589995 0.00609383891055805 MirTarget -0.104865468815509 3.02257267140541e-06 NA NA NA hsa-miR-148b-5p NGFR 1.39335695292409 2.13220380550073e-07 -0.756525762864907 0.0346308387633173 mirMAP -0.284790939209307 8.93729900479724e-05 NA NA NA hsa-miR-15b-3p NGFR 0.804736041893915 0.000400279611457186 -0.756525762864907 0.0346308387633173 mirMAP -0.247701108356659 0.00117487688828093 NA NA NA hsa-miR-2355-5p NGFR 1.86174980095465 3.47492783095613e-13 -0.756525762864907 0.0346308387633173 mirMAP -0.186100473533598 0.00644610713690332 NA NA NA hsa-miR-361-5p NR4A1 0.21454431962475 0.0800957579368424 -2.14549816305305 6.87814315982894e-09 miRanda -0.444578377340064 0.00204617196369179 NA NA NA hsa-miR-542-3p NR4A1 1.62226640768239 2.6427102465476e-10 -2.14549816305305 6.87814315982894e-09 PITA;miRanda -0.330110609836865 5.06420443022426e-07 NA NA NA hsa-miR-145-5p NRAS -1.34926078156437 2.63526538800669e-07 0.110922789912811 0.412920190999736 miRNAWalker2_validate;MirTarget;miRNATAP -0.142760374746012 6.05977027346954e-10 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-148a-3p NRAS 2.30885799126944 1.95226081368985e-21 0.110922789912811 0.412920190999736 MirTarget -0.109343012733505 6.98144190286614e-06 NA NA NA hsa-miR-195-3p NRAS -1.33068822339418 6.65427393047357e-09 0.110922789912811 0.412920190999736 mirMAP -0.160994991063139 1.05944502094987e-09 NA NA NA hsa-miR-22-3p NRAS 1.42501909916631 1.72295005910055e-25 0.110922789912811 0.412920190999736 MirTarget;miRNATAP -0.128848632159027 0.00314401368706814 NA NA NA hsa-miR-26b-5p NRAS 0.72362441215247 4.7794659748036e-05 0.110922789912811 0.412920190999736 mirMAP;miRNATAP -0.130094780209659 0.000185700963505737 NA NA NA hsa-miR-27b-3p NRAS 0.236438984240408 0.12263510345883 0.110922789912811 0.412920190999736 miRNATAP -0.154582178613336 0.000157756473886806 NA NA NA hsa-miR-29a-3p NRAS 0.101650412194573 0.573201097011668 0.110922789912811 0.412920190999736 miRNATAP -0.156058827596967 6.08074898827527e-06 NA NA NA hsa-miR-29b-3p NRAS 3.10527711861309 3.01242507282711e-32 0.110922789912811 0.412920190999736 miRNATAP -0.130094390329954 2.14950403130123e-09 NA NA NA hsa-miR-29c-3p NRAS 1.32354490728858 1.84279305179762e-07 0.110922789912811 0.412920190999736 miRNATAP -0.132620598651339 2.93062944029642e-08 NA NA NA hsa-miR-320a NRAS -0.961144925954715 1.62478794429204e-08 0.110922789912811 0.412920190999736 mirMAP -0.138653847620251 0.000123789780187142 NA NA NA hsa-miR-502-3p NRAS -0.262270070977708 0.161760375279961 0.110922789912811 0.412920190999736 MirTarget -0.116067692488029 0.000491333225482351 NA NA NA hsa-miR-664a-3p NRAS 0.443077463053857 0.0214248925850984 0.110922789912811 0.412920190999736 MirTarget -0.339669060778621 8.1321923374988e-29 NA NA NA hsa-miR-142-3p NTF3 3.98476449801341 1.56256182021111e-35 -1.21316884460928 0.000957794321386974 miRanda -0.132391088121297 0.00694622430224727 NA NA NA hsa-miR-200c-3p NTF3 0.380533388300368 0.0842181838538353 -1.21316884460928 0.000957794321386974 miRNAWalker2_validate;miRNATAP -0.208337360877354 0.00711208431360534 NA NA NA hsa-miR-21-5p NTF3 4.38165933891779 1.52536633902505e-92 -1.21316884460928 0.000957794321386974 miRTarBase;miRNATAP -0.277170192916863 1.64786275260932e-05 NA NA NA hsa-miR-590-3p NTF3 0.83851360565783 0.00129224433453587 -1.21316884460928 0.000957794321386974 miRanda -0.251401735860011 0.00126362075034438 NA NA NA hsa-miR-185-3p NTRK1 -0.377490365509078 0.093653288903368 -1.20191019732804 0.000181518709629851 MirTarget -0.220344116634979 0.000867618792014595 NA NA NA hsa-miR-130b-3p NTRK2 1.83046548750752 5.04753914574694e-13 -2.56364615593132 1.62911334525602e-08 mirMAP -0.588115812319922 3.25886271258664e-12 NA NA NA hsa-miR-130b-5p NTRK2 1.53645187062942 1.10498816261505e-08 -2.56364615593132 1.62911334525602e-08 mirMAP -0.447056548884639 5.74660614017045e-09 NA NA NA hsa-miR-151a-5p NTRK2 1.23124135275661 2.93488020257558e-12 -2.56364615593132 1.62911334525602e-08 miRNATAP -0.404254240257679 0.000623285412545112 NA NA NA hsa-miR-15b-3p NTRK2 0.804736041893915 0.000400279611457186 -2.56364615593132 1.62911334525602e-08 mirMAP -0.277740657056852 0.00473888405637355 NA NA NA hsa-miR-17-3p NTRK2 1.36706429551147 4.60388403547821e-13 -2.56364615593132 1.62911334525602e-08 miRNATAP -0.462037732826128 2.48808237203963e-05 NA NA NA hsa-miR-182-5p NTRK2 3.21839823004635 5.13049145201115e-39 -2.56364615593132 1.62911334525602e-08 mirMAP -0.395114751858306 4.77623924189024e-07 NA NA NA hsa-miR-20a-3p NTRK2 2.51803599558247 4.92479325298629e-13 -2.56364615593132 1.62911334525602e-08 mirMAP -0.364998835563012 1.65748631141832e-06 NA NA NA hsa-miR-21-5p NTRK2 4.38165933891779 1.52536633902505e-92 -2.56364615593132 1.62911334525602e-08 mirMAP -0.470648222362519 3.55420725351027e-09 NA NA NA hsa-miR-29a-5p NTRK2 1.89519956688438 1.03453349363915e-11 -2.56364615593132 1.62911334525602e-08 mirMAP -0.345867869966745 9.99636115678843e-05 NA NA NA hsa-miR-301a-3p NTRK2 2.70198002906399 1.56420889710984e-14 -2.56364615593132 1.62911334525602e-08 mirMAP -0.357966104712284 6.80841814025626e-07 NA NA NA hsa-miR-320b NTRK2 0.226640952564488 0.378818692487242 -2.56364615593132 1.62911334525602e-08 mirMAP -0.286044846597318 0.000526912439992569 NA NA NA hsa-miR-335-3p NTRK2 1.51116383169018 6.88553098788624e-13 -2.56364615593132 1.62911334525602e-08 mirMAP -0.559361058530472 9.51509422827442e-09 NA NA NA hsa-miR-421 NTRK2 0.170525317701774 0.535277026680289 -2.56364615593132 1.62911334525602e-08 mirMAP -0.304690560726909 0.0002799728683427 NA NA NA hsa-miR-454-3p NTRK2 1.49453641052169 4.46235742871434e-09 -2.56364615593132 1.62911334525602e-08 mirMAP -0.333749932009109 0.000672846540177429 NA NA NA hsa-miR-576-5p NTRK2 1.02693643167056 1.14846964470173e-06 -2.56364615593132 1.62911334525602e-08 PITA;mirMAP -0.37738321255992 0.000150408264625595 NA NA NA hsa-miR-590-3p NTRK2 0.83851360565783 0.00129224433453587 -2.56364615593132 1.62911334525602e-08 PITA;miRanda;mirMAP -0.392514341110474 5.33682930755441e-05 NA NA NA hsa-miR-590-5p NTRK2 2.07441240363458 4.95240551694843e-14 -2.56364615593132 1.62911334525602e-08 miRanda;mirMAP -0.40715451036762 1.11592186360866e-05 NA NA NA hsa-let-7d-5p OSMR -0.618145137285851 6.06067642715858e-05 0.385733591661532 0.111305646356038 miRNATAP -0.238108335434953 0.00102596833714279 NA NA NA hsa-miR-200b-3p OSMR 1.55157578247391 4.83790020897188e-09 0.385733591661532 0.111305646356038 TargetScan -0.236637153283022 6.93498025718709e-09 NA NA NA hsa-miR-335-5p OSMR -0.466533891325811 0.0676987038122831 0.385733591661532 0.111305646356038 miRNAWalker2_validate -0.261341914939051 6.67044843056893e-08 NA NA NA hsa-miR-362-3p OSMR 0.194097672030785 0.52808475179225 0.385733591661532 0.111305646356038 miRanda -0.130833842741225 0.00394947318108139 NA NA NA hsa-miR-374a-5p OSMR -0.197027254874826 0.298080902192861 0.385733591661532 0.111305646356038 mirMAP -0.248474817094483 0.000176395395777012 NA NA NA hsa-miR-374b-5p OSMR 0.474691035780475 0.0109217471394203 0.385733591661532 0.111305646356038 mirMAP -0.230294109982855 0.00026780473354388 NA NA NA hsa-miR-429 OSMR 2.3794516574089 1.72813419703734e-13 0.385733591661532 0.111305646356038 miRanda;miRNATAP -0.212394940517193 3.37736358234996e-09 NA NA NA hsa-miR-24-3p PCK2 -0.0357874587555003 0.785865078836504 -0.329919133510267 0.0251973511397516 miRNAWalker2_validate -0.158040917684371 0.00255913249226102 NA NA NA hsa-miR-335-3p PDGFA 1.51116383169018 6.88553098788624e-13 -1.02357928315978 6.32690913682403e-05 mirMAP -0.248081383651425 5.98335990526186e-06 NA NA NA hsa-miR-421 PDGFA 0.170525317701774 0.535277026680289 -1.02357928315978 6.32690913682403e-05 miRanda -0.246541712884684 1.12589234652839e-07 NA NA NA hsa-miR-576-5p PDGFA 1.02693643167056 1.14846964470173e-06 -1.02357928315978 6.32690913682403e-05 mirMAP -0.200616922001446 0.000312414801468213 NA NA NA hsa-miR-590-3p PDGFA 0.83851360565783 0.00129224433453587 -1.02357928315978 6.32690913682403e-05 miRanda -0.159499365763311 0.00342016098327547 NA NA NA hsa-miR-590-5p PDGFA 2.07441240363458 4.95240551694843e-14 -1.02357928315978 6.32690913682403e-05 miRanda -0.168569970910494 0.00119006900103511 NA NA NA hsa-let-7f-5p PDGFB -0.0523311272618407 0.83407808268787 -1.57245721400853 2.64510689458541e-14 miRNATAP -0.111940449788439 0.00438563718329827 NA NA NA hsa-miR-17-5p PDGFB 2.07078488653279 2.77403038572568e-19 -1.57245721400853 2.64510689458541e-14 TargetScan -0.128759642118731 0.00159228819466453 NA NA NA hsa-miR-29b-3p PDGFB 3.10527711861309 3.01242507282711e-32 -1.57245721400853 2.64510689458541e-14 MirTarget;miRNATAP -0.163569333467524 2.06968288487126e-06 NA NA NA hsa-miR-29c-3p PDGFB 1.32354490728858 1.84279305179762e-07 -1.57245721400853 2.64510689458541e-14 MirTarget;miRNATAP -0.160756497303994 2.23137768074853e-05 NA NA NA hsa-miR-16-2-3p PDGFC 0.503964803530872 0.0263648405197492 0.0233013874637775 0.91191903726111 mirMAP -0.175472011716023 0.000148127034743397 NA NA NA hsa-miR-330-5p PDGFC 0.168520831101569 0.336433937906706 0.0233013874637775 0.91191903726111 miRanda -0.205297704063843 0.000217928347062889 NA NA NA hsa-miR-335-3p PDGFC 1.51116383169018 6.88553098788624e-13 0.0233013874637775 0.91191903726111 mirMAP -0.194216460665665 1.42381995093366e-05 NA NA NA hsa-miR-375 PDGFC 0.615547997686534 0.149199273675144 0.0233013874637775 0.91191903726111 miRNAWalker2_validate;miRanda -0.11262292290509 5.19364391065989e-07 NA NA NA hsa-miR-421 PDGFC 0.170525317701774 0.535277026680289 0.0233013874637775 0.91191903726111 miRanda -0.110316895438161 0.00398916648118102 NA NA NA hsa-miR-7-5p PDGFC 0.343825848926135 0.435063427976906 0.0233013874637775 0.91191903726111 miRNAWalker2_validate -0.102774651199499 0.000171471393112032 NA NA NA hsa-miR-19b-1-5p PDGFD 1.71217036351784 3.28561659177495e-12 -0.036065387819836 0.899942301493889 MirTarget -0.186814465461764 0.00206415431431943 NA NA NA hsa-miR-203a-3p PDGFD 1.06866854356847 0.00389979689199624 -0.036065387819836 0.899942301493889 MirTarget -0.153007127618089 1.43396888679748e-05 NA NA NA hsa-miR-320b PDGFD 0.226640952564488 0.378818692487242 -0.036065387819836 0.899942301493889 miRanda -0.183329766510607 0.000344170753203176 NA NA NA hsa-miR-331-5p PDGFD 0.578237334664505 0.00131211239210882 -0.036065387819836 0.899942301493889 MirTarget -0.292523098930857 9.99729887527437e-05 NA NA NA hsa-miR-590-3p PDGFD 0.83851360565783 0.00129224433453587 -0.036065387819836 0.899942301493889 miRanda;mirMAP;miRNATAP -0.183648734809027 0.00242354761671291 NA NA NA hsa-miR-590-5p PDGFD 2.07441240363458 4.95240551694843e-14 -0.036065387819836 0.899942301493889 miRanda -0.233999181813206 4.90533045333196e-05 NA NA NA hsa-miR-7-1-3p PDGFD 2.61364240402652 1.98959237815786e-32 -0.036065387819836 0.899942301493889 mirMAP -0.292442744010984 5.45899275446096e-07 NA NA NA hsa-let-7g-3p PDGFRA 2.38336858943031 4.8771148585792e-17 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.123737451095322 0.00243922499879256 NA NA NA hsa-miR-106a-5p PDGFRA 1.3902608059488 6.07931522284525e-05 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.262061462129381 3.43080881453501e-12 NA NA NA hsa-miR-106b-5p PDGFRA 1.47447672652218 1.32004094930462e-13 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.437339015207479 2.74054790375275e-14 NA NA NA hsa-miR-130b-3p PDGFRA 1.83046548750752 5.04753914574694e-13 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.228770191152218 2.33154390281087e-06 NA NA NA hsa-miR-141-3p PDGFRA 3.36993755486106 5.42939251147195e-32 -0.920353534269053 0.00039437071007992 MirTarget -0.32772250053676 4.14560711921769e-18 NA NA NA hsa-miR-16-1-3p PDGFRA 1.50034693398929 6.63958242991125e-10 -0.920353534269053 0.00039437071007992 MirTarget -0.392102224483284 4.01359006065225e-11 NA NA NA hsa-miR-17-5p PDGFRA 2.07078488653279 2.77403038572568e-19 -0.920353534269053 0.00039437071007992 MirTarget;TargetScan;miRNATAP -0.437831726557654 1.09121275373163e-19 NA NA NA hsa-miR-181b-5p PDGFRA 0.668793269169928 0.000239998092406404 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.243346668635648 0.000221056637302438 NA NA NA hsa-miR-182-5p PDGFRA 3.21839823004635 5.13049145201115e-39 -0.920353534269053 0.00039437071007992 miRNATAP -0.228069978604342 2.76628203495785e-07 NA NA NA hsa-miR-186-5p PDGFRA 0.852175445703945 6.88885738584309e-10 -0.920353534269053 0.00039437071007992 MirTarget -0.444642699585465 2.17102227065078e-07 NA NA NA hsa-miR-200a-3p PDGFRA 3.14766878548496 1.32850889777422e-21 -0.920353534269053 0.00039437071007992 MirTarget -0.223485348461317 1.8870643178893e-10 NA NA NA hsa-miR-20a-5p PDGFRA 2.64649625616975 5.1469418982085e-27 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.375839309283569 3.9000709448395e-17 NA NA NA hsa-miR-20b-5p PDGFRA 1.35770573270947 0.00260808530013016 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.125923024866371 5.86457189774267e-06 NA NA NA hsa-miR-26b-5p PDGFRA 0.72362441215247 4.7794659748036e-05 -0.920353534269053 0.00039437071007992 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.299986293654127 7.81964761899525e-06 NA NA NA hsa-miR-29b-1-5p PDGFRA 1.71024742617744 3.64915691793611e-09 -0.920353534269053 0.00039437071007992 mirMAP -0.203385697475619 4.80726047062849e-07 NA NA NA hsa-miR-29b-3p PDGFRA 3.10527711861309 3.01242507282711e-32 -0.920353534269053 0.00039437071007992 MirTarget -0.210988079915463 6.03805137676526e-07 NA NA NA hsa-miR-301a-3p PDGFRA 2.70198002906399 1.56420889710984e-14 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.242329454445345 2.28119446181804e-09 NA NA NA hsa-miR-3065-5p PDGFRA 0.653308707552535 0.0999497219778851 -0.920353534269053 0.00039437071007992 mirMAP -0.145680616077162 8.34288503273181e-06 NA NA NA hsa-miR-335-3p PDGFRA 1.51116383169018 6.88553098788624e-13 -0.920353534269053 0.00039437071007992 mirMAP -0.345739811848265 3.1636014257612e-10 NA NA NA hsa-miR-338-3p PDGFRA 0.726843067232002 0.0506251324215494 -0.920353534269053 0.00039437071007992 miRanda -0.106588181578414 0.000936971496448231 NA NA NA hsa-miR-339-5p PDGFRA 0.536997313601114 0.0488090394176611 -0.920353534269053 0.00039437071007992 miRanda -0.191797874450638 1.22262689505586e-05 NA NA NA hsa-miR-33a-5p PDGFRA 2.80127809675219 5.09053890529424e-12 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.207468703325488 4.3541979242939e-09 NA NA NA hsa-miR-34a-5p PDGFRA 1.40588612517769 8.60097477768592e-12 -0.920353534269053 0.00039437071007992 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.210491527503148 0.000228547067911926 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-362-3p PDGFRA 0.194097672030785 0.52808475179225 -0.920353534269053 0.00039437071007992 miRanda -0.195936237894039 5.79891842116764e-05 NA NA NA hsa-miR-421 PDGFRA 0.170525317701774 0.535277026680289 -0.920353534269053 0.00039437071007992 PITA;miRanda;miRNATAP -0.173891582150038 0.000247812525545878 NA NA NA hsa-miR-429 PDGFRA 2.3794516574089 1.72813419703734e-13 -0.920353534269053 0.00039437071007992 miRanda;miRNATAP -0.246006444903332 1.87540030422368e-10 NA NA NA hsa-miR-450b-5p PDGFRA 1.69248953402469 1.96052058003353e-07 -0.920353534269053 0.00039437071007992 mirMAP -0.122074687915198 0.00275129796040725 NA NA NA hsa-miR-454-3p PDGFRA 1.49453641052169 4.46235742871434e-09 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.418333685525631 1.11010754867789e-14 NA NA NA hsa-miR-576-5p PDGFRA 1.02693643167056 1.14846964470173e-06 -0.920353534269053 0.00039437071007992 mirMAP -0.298051358520212 9.84291671920344e-08 NA NA NA hsa-miR-589-3p PDGFRA 1.34253876396688 1.84935927493927e-05 -0.920353534269053 0.00039437071007992 mirMAP -0.134517057854286 0.000597797805674663 NA NA NA hsa-miR-590-3p PDGFRA 0.83851360565783 0.00129224433453587 -0.920353534269053 0.00039437071007992 miRanda;mirMAP -0.215815523135662 8.72132841756153e-05 NA NA NA hsa-miR-590-5p PDGFRA 2.07441240363458 4.95240551694843e-14 -0.920353534269053 0.00039437071007992 miRanda -0.320495725599276 6.72663827937009e-10 NA NA NA hsa-miR-7-1-3p PDGFRA 2.61364240402652 1.98959237815786e-32 -0.920353534269053 0.00039437071007992 mirMAP -0.280823951585571 1.24689968872089e-07 NA NA NA hsa-miR-93-5p PDGFRA 1.50844106515467 1.83836866996875e-12 -0.920353534269053 0.00039437071007992 MirTarget;miRNATAP -0.429749525450464 7.91013052237628e-16 NA NA NA hsa-miR-96-5p PDGFRA 3.0381097138467 4.40362891630201e-24 -0.920353534269053 0.00039437071007992 TargetScan;miRNATAP -0.313559555428942 2.60827207243362e-13 NA NA NA hsa-miR-29b-3p PDGFRB 3.10527711861309 3.01242507282711e-32 -0.472627234019869 0.0195049282675806 miRNATAP -0.101003962314959 0.00225724349565461 NA NA NA hsa-miR-3127-5p PDGFRB 0.382717393698386 0.11535780874721 -0.472627234019869 0.0195049282675806 mirMAP -0.153147342374875 6.32703967379545e-05 NA NA NA hsa-miR-421 PDGFRB 0.170525317701774 0.535277026680289 -0.472627234019869 0.0195049282675806 miRanda -0.182914387101734 5.73372143884839e-07 NA NA NA hsa-miR-106b-5p PDPK1 1.47447672652218 1.32004094930462e-13 -0.26368366292376 0.0340750618656775 mirMAP -0.132983936439965 1.77593247426353e-06 NA NA NA hsa-miR-128-3p PDPK1 1.03509868349735 2.11606310588315e-10 -0.26368366292376 0.0340750618656775 miRNAWalker2_validate -0.161462495530987 2.76676989700492e-06 NA NA NA hsa-miR-16-5p PDPK1 0.749619098384047 4.11649450706988e-06 -0.26368366292376 0.0340750618656775 mirMAP -0.118430790715905 0.000724062980260007 NA NA NA hsa-miR-17-5p PDPK1 2.07078488653279 2.77403038572568e-19 -0.26368366292376 0.0340750618656775 miRNAWalker2_validate;mirMAP -0.107136721665695 6.10449319550876e-06 NA NA NA hsa-miR-185-5p PDPK1 1.14291034858482 2.95777119743491e-13 -0.26368366292376 0.0340750618656775 miRNAWalker2_validate -0.11248642658292 0.00170480215738574 NA NA NA hsa-miR-186-5p PDPK1 0.852175445703945 6.88885738584309e-10 -0.26368366292376 0.0340750618656775 mirMAP -0.108329789684716 0.00858347542158776 NA NA NA hsa-miR-22-5p PDPK1 1.71436244278242 9.85038001236064e-15 -0.26368366292376 0.0340750618656775 miRNATAP -0.123784892781515 6.63771805008179e-07 NA NA NA hsa-miR-421 PDPK1 0.170525317701774 0.535277026680289 -0.26368366292376 0.0340750618656775 mirMAP -0.125807153434679 1.79847351270783e-08 NA NA NA hsa-miR-424-5p PDPK1 1.26485330287919 6.1498991028257e-06 -0.26368366292376 0.0340750618656775 mirMAP -0.113642048263266 1.31038105937281e-08 NA NA NA hsa-miR-590-3p PDPK1 0.83851360565783 0.00129224433453587 -0.26368366292376 0.0340750618656775 miRanda;miRNATAP -0.148018696489024 1.11768793717628e-08 NA NA NA hsa-miR-590-5p PDPK1 2.07441240363458 4.95240551694843e-14 -0.26368366292376 0.0340750618656775 miRanda -0.141789138582833 1.02205671237423e-08 NA NA NA hsa-miR-141-3p PHLPP2 3.36993755486106 5.42939251147195e-32 -0.55665406122771 0.000302384294043539 MirTarget;TargetScan;miRNATAP -0.11657832464099 3.85565263920745e-07 24945731 MicroRNA 141 promotes the proliferation of non small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2; Together the results of this study suggest that miR-141 and its targets PHLPP1 and PHLPP2 play critical roles in NSCLC tumorigenesis and provide potential therapeutic targets for NSCLC treatment tumorigenesis lung squamous cell cancer hsa-miR-141-5p PHLPP2 3.02575703771074 1.54385222591327e-32 -0.55665406122771 0.000302384294043539 MirTarget -0.139954955332074 5.47475692022669e-08 24945731 MicroRNA 141 promotes the proliferation of non small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2; Together the results of this study suggest that miR-141 and its targets PHLPP1 and PHLPP2 play critical roles in NSCLC tumorigenesis and provide potential therapeutic targets for NSCLC treatment tumorigenesis lung squamous cell cancer hsa-miR-16-5p PHLPP2 0.749619098384047 4.11649450706988e-06 -0.55665406122771 0.000302384294043539 MirTarget;miRNATAP -0.171697758945455 8.05570171842825e-05 NA NA NA hsa-miR-26b-5p PHLPP2 0.72362441215247 4.7794659748036e-05 -0.55665406122771 0.000302384294043539 miRNAWalker2_validate -0.205778925639279 2.0328203856329e-07 NA NA NA hsa-miR-27b-3p PHLPP2 0.236438984240408 0.12263510345883 -0.55665406122771 0.000302384294043539 MirTarget;miRNATAP -0.141769563012828 0.00255831233335518 NA NA NA hsa-miR-28-5p PHLPP2 1.19639196514745 4.59365801666536e-18 -0.55665406122771 0.000302384294043539 miRanda -0.138645751556634 0.00587702299182292 NA NA NA hsa-miR-29a-3p PHLPP2 0.101650412194573 0.573201097011668 -0.55665406122771 0.000302384294043539 miRNATAP -0.109701181870977 0.00584204153634276 NA NA NA hsa-miR-29c-3p PHLPP2 1.32354490728858 1.84279305179762e-07 -0.55665406122771 0.000302384294043539 miRNATAP -0.116845481014934 2.27847306616397e-05 NA NA NA hsa-miR-92a-3p PHLPP2 -0.136362762339122 0.493412263619364 -0.55665406122771 0.000302384294043539 MirTarget;miRNATAP -0.106533526836444 0.0030595181625216 NA NA NA hsa-miR-106b-5p PIK3AP1 1.47447672652218 1.32004094930462e-13 -0.983061023451854 0.000122314117381668 miRNAWalker2_validate -0.351541003724001 8.52261264664626e-10 NA NA NA hsa-miR-107 PIK3AP1 0.658676029898313 5.11480446318819e-07 -0.983061023451854 0.000122314117381668 miRanda -0.34099274005464 0.000165665244993528 NA NA NA hsa-miR-182-5p PIK3AP1 3.21839823004635 5.13049145201115e-39 -0.983061023451854 0.000122314117381668 MirTarget -0.309339648645043 8.15372229286836e-13 NA NA NA hsa-miR-29a-5p PIK3AP1 1.89519956688438 1.03453349363915e-11 -0.983061023451854 0.000122314117381668 mirMAP -0.134321044893107 0.00703419518973758 NA NA NA hsa-miR-32-5p PIK3AP1 0.876853679269853 6.04859399018691e-05 -0.983061023451854 0.000122314117381668 MirTarget -0.262537571342199 6.72079918570192e-06 NA NA NA hsa-miR-582-5p PIK3AP1 1.08286181406653 0.00149040450161757 -0.983061023451854 0.000122314117381668 MirTarget -0.12035608594715 0.000688162492399718 NA NA NA hsa-miR-92a-3p PIK3AP1 -0.136362762339122 0.493412263619364 -0.983061023451854 0.000122314117381668 MirTarget -0.230255946265737 0.000115338906767189 NA NA NA hsa-miR-92b-3p PIK3AP1 0.0478787637665503 0.831716894621477 -0.983061023451854 0.000122314117381668 MirTarget -0.178472862331974 0.000719946295544725 NA NA NA hsa-miR-186-5p PIK3CA 0.852175445703945 6.88885738584309e-10 -0.335143841150832 0.0107695904000801 mirMAP -0.158211833933772 0.000271764939125213 NA NA NA hsa-miR-501-5p PIK3CA 0.411357595674671 0.10435288464149 -0.335143841150832 0.0107695904000801 mirMAP -0.12161859871495 2.80222388365699e-07 NA NA NA hsa-miR-96-5p PIK3CA 3.0381097138467 4.40362891630201e-24 -0.335143841150832 0.0107695904000801 TargetScan -0.126074442438012 7.26672594996813e-09 NA NA NA hsa-miR-454-3p PIK3CB 1.49453641052169 4.46235742871434e-09 0.0520424688078016 0.708498300848208 miRNATAP -0.107092855274913 0.000279808925292599 NA NA NA hsa-miR-421 PIK3CD 0.170525317701774 0.535277026680289 -0.165252183051274 0.400815192488832 miRanda -0.187035284767016 1.2803934448503e-07 NA NA NA hsa-miR-148b-3p PIK3CG 0.483970528590224 0.0026495409465901 -1.19325793461087 5.28114748039233e-05 miRNAWalker2_validate -0.239430332797948 0.00515332606189168 NA NA NA hsa-miR-26b-5p PIK3CG 0.72362441215247 4.7794659748036e-05 -1.19325793461087 5.28114748039233e-05 miRNAWalker2_validate -0.285401672500096 0.000198071700272844 NA NA NA hsa-miR-29b-3p PIK3CG 3.10527711861309 3.01242507282711e-32 -1.19325793461087 5.28114748039233e-05 miRTarBase -0.13454994451672 0.00563635188925694 NA NA NA hsa-miR-335-3p PIK3CG 1.51116383169018 6.88553098788624e-13 -1.19325793461087 5.28114748039233e-05 mirMAP -0.273824058387904 1.51960031354635e-05 NA NA NA hsa-miR-542-3p PIK3CG 1.62226640768239 2.6427102465476e-10 -1.19325793461087 5.28114748039233e-05 miRanda -0.188110029792226 0.000315799878113487 NA NA NA hsa-miR-106a-5p PIK3R1 1.3902608059488 6.07931522284525e-05 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.152594260668069 8.26964346589391e-10 NA NA NA hsa-miR-106b-5p PIK3R1 1.47447672652218 1.32004094930462e-13 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.274486784039244 3.92361901886501e-13 NA NA NA hsa-miR-128-3p PIK3R1 1.03509868349735 2.11606310588315e-10 -1.28526113405546 1.1596112892202e-14 MirTarget -0.262733562571172 2.81828198129055e-08 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 0.845987603184611 0.000579808501723616 -1.28526113405546 1.1596112892202e-14 MirTarget -0.252566507630763 3.89638206850943e-16 NA NA NA hsa-miR-15a-5p PIK3R1 1.62575353599172 1.55312121019827e-19 -1.28526113405546 1.1596112892202e-14 MirTarget -0.198845640675418 2.2459439580454e-06 NA NA NA hsa-miR-16-2-3p PIK3R1 0.503964803530872 0.0263648405197492 -1.28526113405546 1.1596112892202e-14 MirTarget -0.215346374588015 7.85659740371802e-09 NA NA NA hsa-miR-16-5p PIK3R1 0.749619098384047 4.11649450706988e-06 -1.28526113405546 1.1596112892202e-14 MirTarget -0.14663084031301 0.00245632583144358 NA NA NA hsa-miR-17-5p PIK3R1 2.07078488653279 2.77403038572568e-19 -1.28526113405546 1.1596112892202e-14 MirTarget;TargetScan;miRNATAP -0.30827377198364 1.00416866782136e-22 NA NA NA hsa-miR-182-5p PIK3R1 3.21839823004635 5.13049145201115e-39 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.153577568348738 1.31399000956901e-07 NA NA NA hsa-miR-185-5p PIK3R1 1.14291034858482 2.95777119743491e-13 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.266123472564886 5.49627003455298e-08 NA NA NA hsa-miR-186-5p PIK3R1 0.852175445703945 6.88885738584309e-10 -1.28526113405546 1.1596112892202e-14 mirMAP -0.266496146428416 2.3226235073163e-06 NA NA NA hsa-miR-200c-3p PIK3R1 0.380533388300368 0.0842181838538353 -1.28526113405546 1.1596112892202e-14 mirMAP -0.174738637328334 9.22364461849854e-07 NA NA NA hsa-miR-20a-5p PIK3R1 2.64649625616975 5.1469418982085e-27 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.268255645046992 2.93530513676098e-20 NA NA NA hsa-miR-21-5p PIK3R1 4.38165933891779 1.52536633902505e-92 -1.28526113405546 1.1596112892202e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.239855941401679 1.66617444081141e-16 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 1.71436244278242 9.85038001236064e-15 -1.28526113405546 1.1596112892202e-14 mirMAP -0.249170402831725 1.77307790115702e-13 NA NA NA hsa-miR-29b-3p PIK3R1 3.10527711861309 3.01242507282711e-32 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.169264704761152 8.1620915503371e-10 NA NA NA hsa-miR-335-3p PIK3R1 1.51116383169018 6.88553098788624e-13 -1.28526113405546 1.1596112892202e-14 mirMAP -0.174731000503181 1.56931158200611e-06 NA NA NA hsa-miR-424-5p PIK3R1 1.26485330287919 6.1498991028257e-06 -1.28526113405546 1.1596112892202e-14 MirTarget -0.120660860108298 1.41199550729587e-05 NA NA NA hsa-miR-450b-5p PIK3R1 1.69248953402469 1.96052058003353e-07 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.105483872062601 7.60035078150308e-05 NA NA NA hsa-miR-582-5p PIK3R1 1.08286181406653 0.00149040450161757 -1.28526113405546 1.1596112892202e-14 mirMAP -0.121659359408152 1.98808465862233e-07 NA NA NA hsa-miR-589-3p PIK3R1 1.34253876396688 1.84935927493927e-05 -1.28526113405546 1.1596112892202e-14 mirMAP -0.110115880585781 1.73041185531321e-05 NA NA NA hsa-miR-590-3p PIK3R1 0.83851360565783 0.00129224433453587 -1.28526113405546 1.1596112892202e-14 miRanda;mirMAP -0.21433969556349 1.93094554722457e-09 NA NA NA hsa-miR-590-5p PIK3R1 2.07441240363458 4.95240551694843e-14 -1.28526113405546 1.1596112892202e-14 MirTarget;PITA;miRanda;miRNATAP -0.297606057222883 4.39734655384069e-19 NA NA NA hsa-miR-629-3p PIK3R1 1.31892116211001 0.000114487182853678 -1.28526113405546 1.1596112892202e-14 MirTarget -0.155200085033098 2.2200629415611e-10 NA NA NA hsa-miR-93-5p PIK3R1 1.50844106515467 1.83836866996875e-12 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.302548872464343 3.62432128460294e-18 NA NA NA hsa-miR-96-5p PIK3R1 3.0381097138467 4.40362891630201e-24 -1.28526113405546 1.1596112892202e-14 TargetScan;miRNATAP -0.247820034174453 4.28366535969023e-19 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.71024742617744 3.64915691793611e-09 -0.993075734580867 1.37876508579496e-06 mirMAP -0.137607471527013 2.02669327816331e-05 NA NA NA hsa-miR-335-3p PIK3R3 1.51116383169018 6.88553098788624e-13 -0.993075734580867 1.37876508579496e-06 mirMAP -0.239450639911665 5.21180596069304e-08 NA NA NA hsa-miR-107 PIK3R5 0.658676029898313 5.11480446318819e-07 -1.41857329052665 4.9150449517908e-09 miRanda -0.303365993068523 0.000471196296141979 NA NA NA hsa-miR-182-5p PIK3R5 3.21839823004635 5.13049145201115e-39 -1.41857329052665 4.9150449517908e-09 MirTarget -0.327566926397612 1.58877421029473e-15 NA NA NA hsa-miR-140-5p PKN2 0.669142684153918 0.000335928403032308 0.0787748246707594 0.523073576346193 MirTarget;miRanda -0.107300463746851 0.000551220857656883 NA NA NA hsa-miR-199a-5p PKN2 1.3057193856884 2.38429382751645e-08 0.0787748246707594 0.523073576346193 miRNATAP -0.133543555600679 1.44312804612754e-08 NA NA NA hsa-miR-29b-2-5p PKN2 0.345881055247341 0.194842633194187 0.0787748246707594 0.523073576346193 MirTarget -0.119843488750898 1.0560653400615e-08 NA NA NA hsa-miR-664a-3p PKN2 0.443077463053857 0.0214248925850984 0.0787748246707594 0.523073576346193 MirTarget -0.154445002306727 1.18695444658731e-07 NA NA NA hsa-miR-125a-5p PPP2CA -1.04824536696301 3.97386082850476e-07 0.00351977565606187 0.97004225712613 miRanda -0.108592476267422 9.06041337720993e-08 NA NA NA hsa-miR-30c-5p PPP2CA -0.327319105755825 0.123595832152687 0.00351977565606187 0.97004225712613 mirMAP -0.131381693408342 3.54219270743565e-11 NA NA NA hsa-miR-664a-3p PPP2CA 0.443077463053857 0.0214248925850984 0.00351977565606187 0.97004225712613 mirMAP -0.129991418169681 3.46486829402912e-09 NA NA NA hsa-miR-183-5p PPP2CB 2.39247234736657 3.92444525331999e-21 -0.810479191024634 2.22590279447859e-10 MirTarget;miRNATAP -0.107046241719826 1.76590312582065e-06 NA NA NA hsa-miR-421 PPP2CB 0.170525317701774 0.535277026680289 -0.810479191024634 2.22590279447859e-10 miRNAWalker2_validate;miRanda -0.101748717017346 1.55432203300377e-05 NA NA NA hsa-miR-425-5p PPP2CB 1.21659524959201 8.01126418494715e-09 -0.810479191024634 2.22590279447859e-10 miRNAWalker2_validate -0.230017713976039 2.01900497107045e-17 NA NA NA hsa-miR-590-3p PPP2CB 0.83851360565783 0.00129224433453587 -0.810479191024634 2.22590279447859e-10 miRanda -0.115437970142581 2.41175906636951e-05 NA NA NA hsa-let-7b-3p PPP2R1B -1.81889978084306 6.9913416210266e-19 0.389306891256743 0.0156214207023678 mirMAP -0.12563396102696 0.000308074800959593 NA NA NA hsa-miR-125a-5p PPP2R1B -1.04824536696301 3.97386082850476e-07 0.389306891256743 0.0156214207023678 PITA;miRanda -0.195127723279487 2.8467995200931e-08 NA NA NA hsa-miR-139-5p PPP2R1B -2.26625553116965 7.22375119369519e-16 0.389306891256743 0.0156214207023678 MirTarget;miRanda -0.141997973480572 1.83424283877756e-08 NA NA NA hsa-miR-146b-5p PPP2R1B 1.0922867893808 5.63754607494775e-06 0.389306891256743 0.0156214207023678 miRanda -0.153736063085509 3.91553637047229e-07 NA NA NA hsa-miR-195-5p PPP2R1B -1.01577502605386 4.80814718341729e-05 0.389306891256743 0.0156214207023678 MirTarget -0.160400894716198 1.92075736299728e-07 NA NA NA hsa-miR-30a-3p PPP2R1B -2.54042202792785 2.9111625410859e-18 0.389306891256743 0.0156214207023678 mirMAP -0.105044026185593 1.59679854839767e-05 NA NA NA hsa-miR-30a-5p PPP2R1B -0.924084264430689 0.000762030454634728 0.389306891256743 0.0156214207023678 miRNATAP -0.144523567937466 5.55199488995584e-08 NA NA NA hsa-miR-30b-5p PPP2R1B 0.358144314839612 0.138026229059594 0.389306891256743 0.0156214207023678 miRNATAP -0.176137121142005 6.61523702854927e-09 NA NA NA hsa-miR-30c-2-3p PPP2R1B -3.10905250533941 6.84550165664783e-27 0.389306891256743 0.0156214207023678 MirTarget -0.104611308214946 1.32100635149458e-05 NA NA NA hsa-miR-30c-5p PPP2R1B -0.327319105755825 0.123595832152687 0.389306891256743 0.0156214207023678 miRNATAP -0.186116442727994 7.75959880994156e-08 NA NA NA hsa-miR-30d-3p PPP2R1B 0.00396376345349925 0.986457040013182 0.389306891256743 0.0156214207023678 mirMAP -0.162627010104191 4.61956599491588e-06 NA NA NA hsa-miR-30d-5p PPP2R1B -0.920901858717441 3.50898334321668e-05 0.389306891256743 0.0156214207023678 miRNATAP -0.166997113759972 3.71778141719134e-07 NA NA NA hsa-miR-497-5p PPP2R1B -0.0546347378264729 0.786205564901684 0.389306891256743 0.0156214207023678 MirTarget -0.240684090468845 3.54495469439715e-11 NA NA NA hsa-miR-500a-5p PPP2R2A 0.648155655714409 0.0104657432932038 0.0610689916481766 0.662377371351536 MirTarget -0.13814413769406 7.97915323474903e-08 NA NA NA hsa-miR-107 PPP2R2B 0.658676029898313 5.11480446318819e-07 -0.27163412728623 0.372359484020823 miRanda -0.337356946296675 0.00165068158338141 NA NA NA hsa-miR-141-3p PPP2R2B 3.36993755486106 5.42939251147195e-32 -0.27163412728623 0.372359484020823 TargetScan -0.26084558997887 6.79355201656557e-09 NA NA NA hsa-miR-181a-2-3p PPP2R2C -0.0760679893470186 0.687414621472156 2.23743913738767 0.00280304997022731 MirTarget -0.629334737531362 0.000630122490278799 NA NA NA hsa-miR-181b-5p PPP2R2C 0.668793269169928 0.000239998092406404 2.23743913738767 0.00280304997022731 mirMAP -0.947207807885688 5.07193085421739e-07 NA NA NA hsa-miR-500a-3p PPP2R2C -0.137335632790721 0.545751862031252 2.23743913738767 0.00280304997022731 MirTarget -0.440317085037529 0.00397879069860919 NA NA NA hsa-miR-140-3p PPP2R2D -1.11373309124537 8.35257079443689e-14 0.163212402060736 0.113986847000437 mirMAP -0.167155460525702 5.876516980066e-08 NA NA NA hsa-miR-128-3p PPP2R3A 1.03509868349735 2.11606310588315e-10 0.289095989624743 0.127908275938731 MirTarget -0.168185492226455 0.00149856484477803 NA NA NA hsa-miR-145-5p PPP2R3A -1.34926078156437 2.63526538800669e-07 0.289095989624743 0.127908275938731 MirTarget -0.138901186022008 2.25019731590777e-05 NA NA NA hsa-miR-148b-3p PPP2R3A 0.483970528590224 0.0026495409465901 0.289095989624743 0.127908275938731 miRNAWalker2_validate -0.269886938660133 6.09679248023939e-07 NA NA NA hsa-miR-17-5p PPP2R3A 2.07078488653279 2.77403038572568e-19 0.289095989624743 0.127908275938731 mirMAP -0.125810821604951 0.00054046779870274 NA NA NA hsa-miR-181c-5p PPP2R3A 0.529875814537156 0.0125885822998008 0.289095989624743 0.127908275938731 MirTarget -0.157539705305749 0.000125019676031606 NA NA NA hsa-miR-20b-5p PPP2R3A 1.35770573270947 0.00260808530013016 0.289095989624743 0.127908275938731 mirMAP -0.101874598047085 4.21648362758796e-07 NA NA NA hsa-miR-26b-5p PPP2R3A 0.72362441215247 4.7794659748036e-05 0.289095989624743 0.127908275938731 miRNATAP -0.13694387575683 0.00526667450648939 NA NA NA hsa-miR-320b PPP2R3A 0.226640952564488 0.378818692487242 0.289095989624743 0.127908275938731 miRanda -0.147888848118126 1.21091821131878e-05 NA NA NA hsa-miR-590-3p PPP2R3A 0.83851360565783 0.00129224433453587 0.289095989624743 0.127908275938731 MirTarget;PITA;miRanda -0.122034003533203 0.00233794173015354 NA NA NA hsa-miR-628-5p PPP2R3A 1.06173574237323 4.67541261016756e-06 0.289095989624743 0.127908275938731 MirTarget -0.204590911247692 4.292902044402e-06 NA NA NA hsa-miR-93-5p PPP2R3A 1.50844106515467 1.83836866996875e-12 0.289095989624743 0.127908275938731 mirMAP -0.137343296551951 0.000570385084755362 NA NA NA hsa-miR-197-3p PPP2R5A -1.2979654860824 1.79649132641813e-07 -0.737226577258355 1.38948777844013e-06 MirTarget -0.113718473107373 5.1741723703863e-05 NA NA NA hsa-miR-484 PPP2R5A -0.228576985124486 0.244112867390855 -0.737226577258355 1.38948777844013e-06 miRNAWalker2_validate -0.149079813921877 3.8434359864137e-05 NA NA NA hsa-miR-590-3p PPP2R5A 0.83851360565783 0.00129224433453587 -0.737226577258355 1.38948777844013e-06 miRNAWalker2_validate -0.134330436348155 3.47031052105344e-05 NA NA NA hsa-let-7c-5p PPP2R5E -2.14139413005852 1.66416999341685e-18 0.332284939671954 0.0100148820415654 miRNAWalker2_validate -0.101104767775318 1.43985412604838e-05 NA NA NA hsa-miR-101-5p PPP2R5E -0.0265235292039296 0.917878791358577 0.332284939671954 0.0100148820415654 MirTarget -0.175706519340553 5.76287510708925e-10 NA NA NA hsa-miR-125a-5p PPP2R5E -1.04824536696301 3.97386082850476e-07 0.332284939671954 0.0100148820415654 miRNAWalker2_validate -0.191107713661807 7.4143942159604e-12 NA NA NA hsa-miR-139-5p PPP2R5E -2.26625553116965 7.22375119369519e-16 0.332284939671954 0.0100148820415654 miRanda -0.13104117044849 6.81254893679034e-11 NA NA NA hsa-miR-181a-5p PPP2R5E -0.375429731222937 0.0562142867129802 0.332284939671954 0.0100148820415654 MirTarget;mirMAP -0.175248242128189 4.65235981309525e-09 NA NA NA hsa-miR-181c-5p PPP2R5E 0.529875814537156 0.0125885822998008 0.332284939671954 0.0100148820415654 MirTarget;mirMAP -0.148965234554764 7.52861426176726e-08 NA NA NA hsa-miR-195-3p PPP2R5E -1.33068822339418 6.65427393047357e-09 0.332284939671954 0.0100148820415654 mirMAP -0.129047075492654 3.60058877512595e-07 NA NA NA hsa-miR-29b-2-5p PPP2R5E 0.345881055247341 0.194842633194187 0.332284939671954 0.0100148820415654 mirMAP -0.173091702457262 1.22765592293387e-15 NA NA NA hsa-miR-30a-5p PPP2R5E -0.924084264430689 0.000762030454634728 0.332284939671954 0.0100148820415654 mirMAP -0.133057326058358 3.35539684717347e-10 NA NA NA hsa-miR-30b-5p PPP2R5E 0.358144314839612 0.138026229059594 0.332284939671954 0.0100148820415654 mirMAP -0.137573155177901 1.56046204052055e-08 NA NA NA hsa-miR-30c-5p PPP2R5E -0.327319105755825 0.123595832152687 0.332284939671954 0.0100148820415654 mirMAP -0.251273126950616 9.28476773142478e-21 NA NA NA hsa-miR-342-3p PPP2R5E -0.128691966564961 0.561034080130801 0.332284939671954 0.0100148820415654 miRanda -0.139443209753984 1.68863055966247e-07 NA NA NA hsa-miR-374a-5p PPP2R5E -0.197027254874826 0.298080902192861 0.332284939671954 0.0100148820415654 mirMAP -0.165778694891557 2.33707290307724e-06 NA NA NA hsa-miR-374b-5p PPP2R5E 0.474691035780475 0.0109217471394203 0.332284939671954 0.0100148820415654 mirMAP -0.120646792342735 0.000335420602376512 NA NA NA hsa-miR-455-5p PPP2R5E 1.36946341828134 5.05118627562807e-08 0.332284939671954 0.0100148820415654 miRanda -0.121105556931124 6.19726469499623e-06 NA NA NA hsa-miR-500a-3p PPP2R5E -0.137335632790721 0.545751862031252 0.332284939671954 0.0100148820415654 MirTarget -0.109857589320004 2.53627654305541e-05 NA NA NA hsa-miR-501-5p PPP2R5E 0.411357595674671 0.10435288464149 0.332284939671954 0.0100148820415654 MirTarget;PITA;mirMAP;miRNATAP -0.12370951932419 9.94452362095094e-08 NA NA NA hsa-miR-502-3p PPP2R5E -0.262270070977708 0.161760375279961 0.332284939671954 0.0100148820415654 MirTarget;PITA;miRNATAP -0.122950452888709 0.000108136086069841 NA NA NA hsa-miR-130a-3p PRKAA1 0.881660100597014 0.000158893668519248 0.176948925816615 0.18584938395102 MirTarget;miRNATAP -0.134550408690526 2.13547664400238e-07 NA NA NA hsa-miR-146b-3p PRKAA1 -0.808296168180355 0.000870284326590347 0.176948925816615 0.18584938395102 MirTarget;PITA;miRNATAP -0.138287966858846 2.87259056315393e-08 NA NA NA hsa-miR-15a-5p PRKAA1 1.62575353599172 1.55312121019827e-19 0.176948925816615 0.18584938395102 MirTarget -0.139498587712748 2.0938212928926e-05 NA NA NA hsa-miR-15b-5p PRKAA1 -1.25935038177398 1.83460220856901e-12 0.176948925816615 0.18584938395102 MirTarget -0.105815453966907 0.00169246229615882 NA NA NA hsa-miR-497-5p PRKAA1 -0.0546347378264729 0.786205564901684 0.176948925816615 0.18584938395102 MirTarget -0.127996624125465 2.72701958097883e-05 NA NA NA hsa-let-7b-3p PRKAA2 -1.81889978084306 6.9913416210266e-19 0.538393374272207 0.161947097377576 mirMAP -0.240523717163737 0.00394798493434319 NA NA NA hsa-let-7b-5p PRKAA2 -1.62016148171663 1.56547487335694e-15 0.538393374272207 0.161947097377576 miRNAWalker2_validate;MirTarget -0.271771541704824 0.0013415232460047 NA NA NA hsa-let-7c-5p PRKAA2 -2.14139413005852 1.66416999341685e-18 0.538393374272207 0.161947097377576 MirTarget -0.193073682628501 0.00583564514868253 NA NA NA hsa-miR-181a-5p PRKAA2 -0.375429731222937 0.0562142867129802 0.538393374272207 0.161947097377576 mirMAP -0.311080031450075 0.000579878404322497 NA NA NA hsa-miR-195-3p PRKAA2 -1.33068822339418 6.65427393047357e-09 0.538393374272207 0.161947097377576 mirMAP -0.229466349604648 0.00267676408985009 NA NA NA hsa-miR-224-3p PRKAA2 0.921090817288022 0.010010047721564 0.538393374272207 0.161947097377576 mirMAP -0.248496162993324 1.14191896162547e-06 NA NA NA hsa-miR-3065-5p PRKAA2 0.653308707552535 0.0999497219778851 0.538393374272207 0.161947097377576 mirMAP;miRNATAP -0.195172355521502 5.33128383987359e-05 NA NA NA hsa-miR-30a-3p PRKAA2 -2.54042202792785 2.9111625410859e-18 0.538393374272207 0.161947097377576 MirTarget;miRNATAP -0.236648976996956 4.87801912942201e-05 NA NA NA hsa-miR-30a-5p PRKAA2 -0.924084264430689 0.000762030454634728 0.538393374272207 0.161947097377576 MirTarget -0.237163243849172 0.000217608017414726 NA NA NA hsa-miR-30e-3p PRKAA2 -0.104420043859122 0.526240453209293 0.538393374272207 0.161947097377576 MirTarget -0.432424323338152 6.49846424605619e-05 NA NA NA hsa-miR-338-5p PRKAA2 -1.83316380675941 4.03269924759167e-07 0.538393374272207 0.161947097377576 mirMAP -0.135451315631486 0.00509488170288173 NA NA NA hsa-miR-452-3p PRKAA2 0.477736876273128 0.22218404598603 0.538393374272207 0.161947097377576 mirMAP -0.138574793467526 0.00859738947393167 NA NA NA hsa-miR-17-3p PRKCA 1.36706429551147 4.60388403547821e-13 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.2211557176846 0.000413342702730225 NA NA NA hsa-miR-181c-5p PRKCA 0.529875814537156 0.0125885822998008 -0.189679589892687 0.471078192212991 mirMAP -0.326745565499583 6.66432412436314e-09 NA NA NA hsa-miR-183-5p PRKCA 2.39247234736657 3.92444525331999e-21 -0.189679589892687 0.471078192212991 miRNATAP -0.191021307259656 2.63755654536705e-05 NA NA NA hsa-miR-193b-3p PRKCA 1.10444771306846 0.000822888533401377 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.138487066621768 0.000138664149309437 NA NA NA hsa-miR-193b-5p PRKCA 0.179695858885499 0.55521472494233 -0.189679589892687 0.471078192212991 mirMAP -0.137899397693864 0.000521039895191079 NA NA NA hsa-miR-19b-1-5p PRKCA 1.71217036351784 3.28561659177495e-12 -0.189679589892687 0.471078192212991 mirMAP -0.210975845049586 0.000143708055393517 NA NA NA hsa-miR-200c-3p PRKCA 0.380533388300368 0.0842181838538353 -0.189679589892687 0.471078192212991 miRNATAP -0.262911308228053 1.5097135867061e-06 NA NA NA hsa-miR-22-5p PRKCA 1.71436244278242 9.85038001236064e-15 -0.189679589892687 0.471078192212991 mirMAP -0.177526746625668 0.000829577475678236 NA NA NA hsa-miR-429 PRKCA 2.3794516574089 1.72813419703734e-13 -0.189679589892687 0.471078192212991 miRanda;miRNATAP -0.142853746691809 0.000293353456114152 NA NA NA hsa-miR-590-3p PRKCA 0.83851360565783 0.00129224433453587 -0.189679589892687 0.471078192212991 PITA;miRanda;mirMAP;miRNATAP -0.19448195031258 0.000455368438666445 NA NA NA hsa-miR-92a-3p PRKCA -0.136362762339122 0.493412263619364 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.160805726714066 0.00861285946041943 NA NA NA hsa-miR-93-3p PRKCA 1.07631808403007 1.63747525692813e-05 -0.189679589892687 0.471078192212991 mirMAP -0.159060267220526 0.000935006714973491 NA NA NA hsa-miR-103a-3p PTEN 0.538497806383155 1.88134691850591e-05 -0.41901734874011 0.000137135697667474 miRNAWalker2_validate;miRTarBase -0.178416761140974 1.0244122893712e-05 26511107;24828205 LncRNA GAS5 induces PTEN expression through inhibiting miR 103 in endometrial cancer cells; To investigate the expression of GAS5 PTEN and miR-103 RT-PCR was performed; Finally we found that miR-103 mimic could decrease the mRNA and protein levels of PTEN through luciferase reporter assay and western blotting and GAS5 plasmid may reverse this regulation effect in endometrial cancer cells; Through inhibiting the expression of miR-103 GAS5 significantly enhanced the expression of PTEN to promote cancer cell apoptosis and thus could be an important mediator in the pathogenesis of endometrial cancer;Our data collectively demonstrate that miR-103 is an oncogene miRNA that promotes colorectal cancer proliferation and migration through down-regulation of the tumor suppressor genes DICER and PTEN ; endometrial cancer;colorectal cancer hsa-miR-106a-5p PTEN 1.3902608059488 6.07931522284525e-05 -0.41901734874011 0.000137135697667474 miRNATAP -0.130885292313782 7.81301360715351e-17 26097565;26318586 miR 106a promotes growth and metastasis of non small cell lung cancer by targeting PTEN; Furthermore the presence of miR-106a was inversely correlated with PTEN in NSCLC tissues; Overall this study suggested that miR-106a inhibited the growth and metastasis of NSCLC cells by decreasing PTEN expression;Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo metastasis; lung squamous cell cancer;prostate cancer hsa-miR-106b-5p PTEN 1.47447672652218 1.32004094930462e-13 -0.41901734874011 0.000137135697667474 miRNAWalker2_validate;miRTarBase;miRNATAP -0.104117444261304 2.59660457077114e-05 24842611;26238857;26722252 MicroRNA 106b in cancer associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN;We further identified PTEN and p21 as novel direct targets of miR-106b by using target prediction algorithms and a luciferase assay; Overexpression of miR-106b reduced the expression of PTEN and p21 and increased the expression of p-AKT which is a downstream of PTEN; Restoring the expression of PTEN or p21 in stably miR-106b-overexpressed cells could rescue the effect of miR-106b on cell radioresistance; These observations illustrated that miR-106b could induce cell radioresistance by directly targeting PTEN and p21 this process was accompanied by tumour-initiating cell capacity enhancement which is universally confirmed to be associated with radioresistance;Cantharidin modulates the E2F1/MCM7 miR 106b 93/p21 PTEN signaling axis in MCF 7 breast cancer cells cell migration;drug resistance; gastric cancer;colorectal cancer;breast cancer hsa-miR-130a-3p PTEN 0.881660100597014 0.000158893668519248 -0.41901734874011 0.000137135697667474 MirTarget;miRNATAP -0.101775551899915 2.13139066434031e-06 24490491;27062783;22614869;26837847;27040383;27035216;26043084 Down-regulated miR-130a did not affect cell proliferations but enhanced the sensitivity of the cells to cisplatin inhibited the expressions of MDR1 mRNA and P-gp and increased the expression of PTEN proteins; MiR-130a inhibitor can reverse the cisplatin resistance by upregulating the expression of PTEN proteins and down-regulating P-gp in A2780 cell lines;Platinum-resistant patients had significantly higher levels of expression of miR-130a and BCL-2 and lower level of PTEN than platinum-sensitive patients P < 0.05; MiR-130a may mediate the generation of platinum resistance in epithelial ovarian cancer through inhibiting PTEN to activate PI3K/AKT signaling pathway and increasing BCL-2 to inhibit tumor cell apoptosis;We found that miR-130a was upregulated in SKOV3/CIS compared to the parental SKOV3 cells and PTEN was predicted to be the potential target of miR-130a;The miR 130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN; In clinical bladder cancer specimens downregulation of PTEN was found to be closely correlated with miR-130 family expression levels;In addition by targeting PTEN 3' untranslated region miR-130a might increase cell growth and initiate protein kinase B AKT pathway activation;MicroRNA 130a promotes the metastasis and epithelial mesenchymal transition of osteosarcoma by targeting PTEN; MiR-130a exerted promoting effects on metastatic behavior and EMT of osteosarcoma cells through suppressing PTEN expression;This role of miR-130a may be achieved by regulating the MDR1 and PTEN gene expression drug resistance;drug resistance;;cell migration;;metastasis; ovarian cancer;ovarian cancer;ovarian cancer;bladder cancer;cervical and endocervical cancer;sarcoma;ovarian cancer hsa-miR-130b-3p PTEN 1.83046548750752 5.04753914574694e-13 -0.41901734874011 0.000137135697667474 MirTarget;miRNATAP -0.109728666497463 7.00361581570123e-08 26837847;25637514 The miR 130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN; In clinical bladder cancer specimens downregulation of PTEN was found to be closely correlated with miR-130 family expression levels;MiR 130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells; We confirmed that miR-130b interacted with the 3'-untranslated region of PTEN and that an increase in the expression level of miR-130b negatively affected the protein level of PTEN; However the dysregulation of miR-130b had no obvious impact on PTEN mRNA; As Akt is a downstream effector of PTEN we explored if miR-130b affected Akt expression and found that miR-130b indirectly regulated the level of phosphorylated Akt while total Akt protein remained unchanged; The results indicate that miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation which would be helpful in developing miRNA-based treatments for ESCC cell migration; bladder cancer;esophageal cancer hsa-miR-141-3p PTEN 3.36993755486106 5.42939251147195e-32 -0.41901734874011 0.000137135697667474 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.103983871313954 1.43928589517751e-10 27644195;24742567 Involvement of microRNA 141 3p in 5 fluorouracil and oxaliplatin chemo resistance in esophageal cancer cells via regulation of PTEN; Western blot exhibited altered protein levels of PTEN Akt and PI3k with miR-141-3p inhibitor; An inverse correlation between PTEN expression and miR-141-3p expression was also observed in tissue samples; Our study demonstrated that miR-141-3p contributed to an acquired chemo-resistance through PTEN modulation both in vitro and in vivo;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis drug resistance;tumorigenesis esophageal cancer;endometrial cancer hsa-miR-148b-3p PTEN 0.483970528590224 0.0026495409465901 -0.41901734874011 0.000137135697667474 MirTarget;miRNATAP -0.130520184239271 3.47762829311644e-05 NA NA NA hsa-miR-16-1-3p PTEN 1.50034693398929 6.63958242991125e-10 -0.41901734874011 0.000137135697667474 MirTarget -0.123272492174072 1.10427479892726e-06 NA NA NA hsa-miR-17-5p PTEN 2.07078488653279 2.77403038572568e-19 -0.41901734874011 0.000137135697667474 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.187397757344705 2.72047461827111e-20 27400681;23391506;23133552;26629823;24462867;26318586;26215320;25634356;26500892;24912422;23418359 GFRα2 prompts cell growth and chemoresistance through down regulating tumor suppressor gene PTEN via Mir 17 5p in pancreatic cancer; Mechanically we discovered that high GFRα2 expression level leads to PTEN inactivation via enhancing Mir-17-5p level;We found that these phenotypes were the results of miR-17 targeting PTEN;PTEN mRNA correlated inversely with miR-92a and members of the miR-17 and miR-130/301 families;We hypothesized that knocking down the oncogenic microRNA oncomiR miR-17-5p might restore the expression levels of PDCD4 and PTEN tumor suppressor proteins illustrating a route to oligonucleotide therapy of TNBC; Contrary to conventional wisdom antisense knockdown of oncomiR miR-17-5p guide strand reduced PDCD4 and PTEN proteins by 1.8±0.3 fold in human TNBC cells instead of raising them; Bioinformatics analysis and folding energy calculations revealed that mRNA targets of miR-17-5p guide strand such as PDCD4 and PTEN could also be regulated by miR-17-3p passenger strand;miR 17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression; Expression of miR-17 was negatively correlated with PTEN in OS tissues;Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR 17 family in prostate cancer; Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo;In addition ERβ expression significantly increased in calycosin-treated HCT-116 cells followed by a decrease of miR-17 and up-regulation of PTEN; Our results indicate that calycosin has an inhibitory effect on CRC which might be obtained by ERβ-mediated regulation of miR-17 and PTEN expression;The High Expression of the microRNA 17 92 Cluster and its Paralogs and the Downregulation of the Target Gene PTEN Is Associated with Primary Cutaneous B Cell Lymphoma Progression;MicroRNA 17 5p induces drug resistance and invasion of ovarian carcinoma cells by targeting PTEN signaling; miR-17-5p activates AKT by downregulation of PTEN in ovarian cancer cells;MicroRNA 17 5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression; We found that PTEN was a target of miR-17-5p in the colon cancer cells and their context-specific interactions were responsible for multiple drug-resistance; Chemotherapy was found to increase the expression levels of miR-17-5p which further repressed PTEN levels contributing to the development of chemo-resistance; MiR-17-5p is a predictive factor for chemotherapy response and a prognostic factor for overall survival in CRC which is due to its regulation of PTEN expression;The mature miR-17-5p exerted this function by repressing the expression of PTEN drug resistance;;;;metastasis;;;progression;drug resistance;metastasis;drug resistance;poor survival; pancreatic cancer;glioblastoma;sarcoma;breast cancer;sarcoma;prostate cancer;colorectal cancer;B cell lymphoma;ovarian cancer;colorectal cancer;liver cancer hsa-miR-186-5p PTEN 0.852175445703945 6.88885738584309e-10 -0.41901734874011 0.000137135697667474 mirMAP;miRNATAP -0.18571264902072 2.84306242795631e-07 NA NA NA hsa-miR-18a-5p PTEN 1.37435209536521 9.2173853686829e-06 -0.41901734874011 0.000137135697667474 miRNAWalker2_validate;miRTarBase -0.141101959733646 1.18775251717657e-16 24681249;27291152 However higher levels of the miR-17~92 cluster switched from PTEN to oncogenes including Ctnnb1 β-catenin via miR-18a which resulted in inhibition of tumor growth and metastasis;miR 18a promotes cell proliferation of esophageal squamous cell carcinoma cells by increasing cylin D1 via regulating PTEN PI3K AKT mTOR signaling axis metastasis; colon cancer;esophageal cancer hsa-miR-193a-3p PTEN 0.549173467360291 0.0319030569365466 -0.41901734874011 0.000137135697667474 PITA;miRanda -0.100107289825292 2.74866825496953e-06 26753960;23223432 Downregulation of microRNA 193 3p inhibits tumor proliferation migration and chemoresistance in human gastric cancer by regulating PTEN gene;Our study identifies miR-193a and PTEN as targets for AML1/ETO and provides evidence that links the epigenetic silencing of tumor suppressor genes miR-193a and PTEN to differentiation block of myeloid precursors drug resistance;differentiation gastric cancer;acute myeloid leukemia hsa-miR-19a-3p PTEN 2.11776595911517 7.07663078397156e-10 -0.41901734874011 0.000137135697667474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.152449210349358 4.83140828337759e-20 26098000;27289489;27445062;24831732;21853360;24681249;25107371 Moreover siRNA-mediated knockdown of PTEN a target of miR-19 also resulted in EMT migration and invasion of A549 and HCC827 cells suggesting that PTEN is involved in miR-19-induced EMT migration and invasion of lung cancer cells;Transfection of miR-19a and -19b mimics reversed the up-regulations of IGF2R and PTEN gene expression and abrogated the GSE induced anti-proliferative response;The target genes of miR-19a such as ABCA1 and PTEN that had been suppressed by miR recovered their expression through CAP treatment;Meanwhile BPA-induced upregulation of oncogenic miR-19a and miR-19b and the dysregulated expression of miR-19-related downstream proteins including PTEN p-AKT p-MDM2 p53 and proliferating cell nuclear antigen were reversed by curcumin;Regulation of miR 19 to breast cancer chemoresistance through targeting PTEN; Expression levels of miR-19 in MDR cells were inversely consistent with those of PTEN; Our findings demonstrate for the first time involvement of miR-19 in multidrug resistance through modulation of PTEN and suggest that miR-19 may be a potential target for preventing and reversing MDR in tumor cells;miR-19 in the context of the miR-17~92 cluster at medium levels promoted tumor metastasis through induction of Wnt/β-catenin-mediated epithelial-mesenchymal transition by targeting to the tumor-suppressor gene PTEN;The target of miR-19a was identified by western blot and whether its regulatory role depends on its target was improved by a rescue experiment with miR-19a mimic and PTEN expression plasmid; Meanwhile gain or loss of function of miR-19a demonstrated that miR-19a can promote cell growth of bladder cancer cells and the further mechanism studies indicated that its oncogenic role was dependent on targeting PTEN; The oncogenic role of miR19a in bladder cancer was dependent on targeting PTEN ;drug resistance;;;drug resistance;metastasis; lung cancer;lung cancer;breast cancer;breast cancer;breast cancer;colon cancer;bladder cancer hsa-miR-19b-3p PTEN 2.10868505662119 5.40846613768389e-17 -0.41901734874011 0.000137135697667474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.144424393781319 5.95919159731141e-13 26098000;24831732;21853360;24681249 Moreover siRNA-mediated knockdown of PTEN a target of miR-19 also resulted in EMT migration and invasion of A549 and HCC827 cells suggesting that PTEN is involved in miR-19-induced EMT migration and invasion of lung cancer cells;Meanwhile BPA-induced upregulation of oncogenic miR-19a and miR-19b and the dysregulated expression of miR-19-related downstream proteins including PTEN p-AKT p-MDM2 p53 and proliferating cell nuclear antigen were reversed by curcumin;Regulation of miR 19 to breast cancer chemoresistance through targeting PTEN; Expression levels of miR-19 in MDR cells were inversely consistent with those of PTEN; Our findings demonstrate for the first time involvement of miR-19 in multidrug resistance through modulation of PTEN and suggest that miR-19 may be a potential target for preventing and reversing MDR in tumor cells;miR-19 in the context of the miR-17~92 cluster at medium levels promoted tumor metastasis through induction of Wnt/β-catenin-mediated epithelial-mesenchymal transition by targeting to the tumor-suppressor gene PTEN ;;drug resistance;metastasis lung cancer;breast cancer;breast cancer;colon cancer hsa-miR-20a-5p PTEN 2.64649625616975 5.1469418982085e-27 -0.41901734874011 0.000137135697667474 miRNAWalker2_validate;miRTarBase;miRNATAP -0.161121765339806 1.05381764637456e-17 26031366 The expression of miR-20a and PTEN were detected in HCC cell lines and paired primary tissues by quantitative real-time polymerase chain reaction; MiR-20a levels were increased in HCC cell lines and tissues whereas PTEN was inversely correlated with it; PTEN was identified as a direct functional target of miR-20a for the induction of radioresistance drug resistance liver cancer hsa-miR-25-3p PTEN 0.361927330834176 0.0163670566170988 -0.41901734874011 0.000137135697667474 miRTarBase;MirTarget;miRNATAP -0.11968562938759 0.000411956693911945 NA NA NA hsa-miR-26b-5p PTEN 0.72362441215247 4.7794659748036e-05 -0.41901734874011 0.000137135697667474 MirTarget;miRNATAP -0.101786450251327 0.000339227897329926 26068649 Down regulation of microRNA 26b modulates non small cell lung cancer cells chemoresistance and migration through the association of PTEN; It indicates that miR-26b may regulate NSCLC migration and chemosensitivity through the regulation of PTEN drug resistance lung squamous cell cancer hsa-miR-301a-3p PTEN 2.70198002906399 1.56420889710984e-14 -0.41901734874011 0.000137135697667474 MirTarget;miRNATAP -0.136185588556865 5.91738747356386e-16 24315818;26846737 Upregulated microRNA 301a in breast cancer promotes tumor metastasis by targeting PTEN and activating Wnt/β catenin signaling; Furthermore miR-301a directly targeted and suppressed PTEN one negative regulator of the Wnt/β-catenin signaling cascade; These results demonstrate that miR-301a maintains constitutively activated Wnt/β-catenin signaling by directly targeting PTEN which promotes breast cancer invasion and metastasis;MicroRNA 301a promotes cell proliferation via PTEN targeting in Ewing's sarcoma cells; Our results demonstrated the novel mechanism controlling PTEN expression via miR-301a in ES cells metastasis; breast cancer;sarcoma hsa-miR-342-3p PTEN -0.128691966564961 0.561034080130801 -0.41901734874011 0.000137135697667474 miRanda -0.12660675779428 2.51472806501277e-08 NA NA NA hsa-miR-425-5p PTEN 1.21659524959201 8.01126418494715e-09 -0.41901734874011 0.000137135697667474 miRNATAP -0.169099257663055 2.9682618955533e-13 25154996 An increase in miR-425 depended upon IL-1β-induced NF-kappaB activation.Repression of PTEN by miR-425 promoted gastric cancer cell proliferation gastric cancer hsa-miR-454-3p PTEN 1.49453641052169 4.46235742871434e-09 -0.41901734874011 0.000137135697667474 MirTarget;miRNATAP -0.207669245917415 3.06891122776166e-20 26296312;27261580 MicroRNA 454 functions as an oncogene by regulating PTEN in uveal melanoma; Furthermore we identified PTEN as a direct target of miR-454; Our data revealed that ectopic expression of PTEN restored the effects of miR-454 on cell proliferation and invasion in uveal melanoma cells;MiR 454 promotes the progression of human non small cell lung cancer and directly targets PTEN; At last the potential regulatory function of miR-454 on PTEN expression was confirmed; Further PTEN was confirmed as a direct target of miR-454 by using Luciferase Reporter Assay ;progression melanoma;lung squamous cell cancer hsa-miR-590-5p PTEN 2.07441240363458 4.95240551694843e-14 -0.41901734874011 0.000137135697667474 mirMAP -0.163531572056391 4.57428223021788e-14 23803188 Targetscan predicted PDCD4 and PTEN as the potential target genes of miR-590-5p and miR-590-3p which was verified by luciferase reporter system and Western blotting liver cancer hsa-miR-7-1-3p PTEN 2.61364240402652 1.98959237815786e-32 -0.41901734874011 0.000137135697667474 mirMAP -0.12353194205425 3.34150554364966e-08 NA NA NA hsa-miR-92a-3p PTEN -0.136362762339122 0.493412263619364 -0.41901734874011 0.000137135697667474 MirTarget;miRNATAP -0.123586887613975 1.14670739856895e-06 26432332;25515201;24137349;23546593;23133552;24026406 Downregulation of PTEN could mimic the same effects of miR-92a mimic in NSCLC cells and rescue the effects on NSCLC cells induced by miR-92a inhibitor; Taken together these findings suggested that miR-92a could promote growth metastasis and chemoresistance in NSCLC cells at least partially by targeting PTEN;MiR 92a Promotes Cell Metastasis of Colorectal Cancer Through PTEN Mediated PI3K/AKT Pathway; The expression of miR-92a PTEN and E-cadherin was analyzed by real-time PCR; In addition there was a negative correlation between levels of miR-92a and the PTEN gene p < 0.0001; The association of levels of miR-92a and PTEN with tumor cell migration in CRC was also confirmed in CRC cell models;MicroRNA miR-92 is overexpressed in a number of tumors and has been proven to negatively regulate a number of tumor suppressor genes including phosphatase and tensin homologue PTEN; PTEN protein expression was decreased in the SiHa cells that were transfected with the miR-92 mimic; The data indicated that miR-92 may increase the migration and invasion of SiHa cells partially through the downregulation of PTEN protein expression;Expression and significance of PTEN and miR 92 in hepatocellular carcinoma; Immunohistochemistry streptavidin-peroxidase SP and quantitative reverse transcriptase-polymerase chain reaction qRT‑PCR were used to detect the expression of PTEN and miR-92 in 15 cases of HCC and the corresponding paracancerous tissues; The correlation between PTEN and miR-92 was analyzed; Additionally the mRNA levels of PTEN and miR-92 showed a significantly negative correlation with each other r=-0.858 P<0.05; In conclusion PTEN and miR-92 have different roles in the development of HCC; The combined detection of PTEN and miR-92 may provide critical clinical evidence for the early diagnosis and prognosis of HCC;PTEN mRNA correlated inversely with miR-92a and members of the miR-17 and miR-130/301 families;The expression levels of miR-92a and phosphatase and tensin homologue PTEN were detected by qRT-PCR and western blot; In addition the regulation of PTEN by miR-92a was evaluated by qRT-PCR western blot and luciferase reporter assays; There was an inverse correlation between the levels of miR-92a and PTEN in CRC tissues; The overexpression of miR-92a in CRC cells decreased PTEN expression at the translational level and decreased PTEN-driven luciferase-reporter activity; Our results demonstrated that miR-92a induced EMT and regulated cell growth migration and invasion in the SW480 cells at least partially via suppression of PTEN expression metastasis;drug resistance;metastasis;cell migration;;worse prognosis;; lung squamous cell cancer;colorectal cancer;cervical and endocervical cancer;liver cancer;sarcoma;colorectal cancer hsa-miR-93-5p PTEN 1.50844106515467 1.83836866996875e-12 -0.41901734874011 0.000137135697667474 miRNAWalker2_validate;miRTarBase;miRNATAP -0.209970443777429 3.2573256879644e-21 25633810;26243299;22465665;26087719 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC;microRNA 93 promotes cell proliferation via targeting of PTEN in Osteosarcoma cells; An miRNA miR-93 was significantly up-regulated whereas phosphatase and tensin homologue PTEN expression was significantly down-regulated in all tested OS cells when compared with hMSCs; Ectopic expression of miR-93 decreased PTEN protein levels; Taking these observations together miR-93 can be seen to play a critical role in carcinogenesis through suppression of PTEN and may serve as a therapeutic target for the treatment of OS;Furthermore we found that miR-93 can directly target PTEN and participates in the regulation of the AKT signaling pathway; MiR-93 inversely correlates with PTEN expression in CDDP-resistant and sensitive human ovarian cancer tissues;Furthermore our study found berberine could inhibit miR-93 expression and function in ovarian cancer as shown by an increase of its target PTEN an important tumor suppressor in ovarian cancer; More importantly A2780 cells that were treated with PTEN siRNA had a survival pattern that is similar to cells with miR-93 overexpression ;tumorigenesis;;poor survival liver cancer;sarcoma;ovarian cancer;ovarian cancer hsa-miR-140-5p PTK2 0.669142684153918 0.000335928403032308 0.278007300053823 0.026596373778384 miRanda -0.161505490487641 2.71491649672642e-07 NA NA NA hsa-miR-30c-5p RAC1 -0.327319105755825 0.123595832152687 0.217355195910818 0.0528286499053578 miRNAWalker2_validate -0.11419324793125 2.23761362474291e-06 NA NA NA hsa-miR-106a-5p RBL2 1.3902608059488 6.07931522284525e-05 -0.516492077682474 5.92305056757779e-05 MirTarget;miRNATAP -0.13392820224047 5.92164837110696e-13 24045973 Among many miR-106a predicated target genes p130 RBL2 an retinoblastoma Rb tumor suppressor family member was not only confirmed as a specific target of miR-106a but also related to tumor growth and differentiation; The importance of mir-106a and RBL2 was further demonstrated in vivo in which SKOV3 cells overexpressing miR-106a formed poorly differentiated carcinomas and had reduced RBL2 levels differentiation ovarian cancer hsa-miR-106b-5p RBL2 1.47447672652218 1.32004094930462e-13 -0.516492077682474 5.92305056757779e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.215341567706376 3.66006092380862e-14 NA NA NA hsa-miR-17-5p RBL2 2.07078488653279 2.77403038572568e-19 -0.516492077682474 5.92305056757779e-05 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.186905102067222 9.65217395879901e-15 NA NA NA hsa-miR-20a-5p RBL2 2.64649625616975 5.1469418982085e-27 -0.516492077682474 5.92305056757779e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.134989231144882 1.97878935904001e-09 NA NA NA hsa-miR-335-3p RBL2 1.51116383169018 6.88553098788624e-13 -0.516492077682474 5.92305056757779e-05 MirTarget -0.132537789684453 1.3444724815766e-06 NA NA NA hsa-miR-421 RBL2 0.170525317701774 0.535277026680289 -0.516492077682474 5.92305056757779e-05 miRanda -0.116350101440375 6.13779131365422e-07 NA NA NA hsa-miR-576-5p RBL2 1.02693643167056 1.14846964470173e-06 -0.516492077682474 5.92305056757779e-05 MirTarget;PITA -0.141843634503635 3.03298315521095e-07 NA NA NA hsa-miR-590-3p RBL2 0.83851360565783 0.00129224433453587 -0.516492077682474 5.92305056757779e-05 miRanda -0.141913330574948 1.52520869660665e-07 NA NA NA hsa-miR-93-5p RBL2 1.50844106515467 1.83836866996875e-12 -0.516492077682474 5.92305056757779e-05 MirTarget;miRNATAP -0.193013530881052 3.65814480460646e-13 NA NA NA hsa-miR-15a-5p RELN 1.62575353599172 1.55312121019827e-19 -2.37208621581551 3.59586041968892e-07 MirTarget;miRNATAP -0.449133191021803 0.000112945954950056 NA NA NA hsa-miR-200b-3p RELN 1.55157578247391 4.83790020897188e-09 -2.37208621581551 3.59586041968892e-07 MirTarget;TargetScan -0.233478084975991 0.00382546015897023 NA NA NA hsa-miR-224-5p RELN 1.9183903633152 3.22216766330296e-06 -2.37208621581551 3.59586041968892e-07 MirTarget -0.235430356074029 5.48748175273142e-06 NA NA NA hsa-miR-34a-5p RELN 1.40588612517769 8.60097477768592e-12 -2.37208621581551 3.59586041968892e-07 miRNATAP -0.493360087505524 1.58915934833312e-06 NA NA NA hsa-miR-429 RELN 2.3794516574089 1.72813419703734e-13 -2.37208621581551 3.59586041968892e-07 MirTarget;PITA;miRanda;miRNATAP -0.300778901880419 2.08283579523103e-05 NA NA NA hsa-miR-338-5p RHEB -1.83316380675941 4.03269924759167e-07 0.556690295005146 5.24242907453425e-05 MirTarget;PITA;miRNATAP -0.106669897326297 4.28378835676612e-10 NA NA NA hsa-miR-139-5p RPS6KB1 -2.26625553116965 7.22375119369519e-16 0.395075168795546 0.000566740506607704 PITA;miRanda -0.110290868714374 7.45237907447142e-10 NA NA NA hsa-miR-145-5p RPS6KB1 -1.34926078156437 2.63526538800669e-07 0.395075168795546 0.000566740506607704 MirTarget;miRNATAP -0.15695919845232 4.51835368672558e-16 24157791 MiR 145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1; MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3'UTRs; Importantly the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145 respectively; Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1 functioning as a tumor suppressor ovarian cancer hsa-miR-181a-5p RPS6KB1 -0.375429731222937 0.0562142867129802 0.395075168795546 0.000566740506607704 MirTarget;miRNATAP -0.12611116022247 2.50376013250516e-06 NA NA NA hsa-miR-181c-5p RPS6KB1 0.529875814537156 0.0125885822998008 0.395075168795546 0.000566740506607704 MirTarget;miRNATAP -0.155514169262014 2.18592208444415e-10 NA NA NA hsa-miR-218-5p RPS6KB1 -0.281408491748349 0.259553612322657 0.395075168795546 0.000566740506607704 miRNATAP -0.162598141425799 1.69303431906451e-14 25943352 We found that decreased miR-218 expression in GBM cells also increased the expression of genes encoding additional upstream and downstream components of RTK signaling pathways including the RTK platelet-derived growth factor receptor α PDGFRα and the kinases ribosomal S6 kinase 2 RSK2 and S6 kinase 1 S6K1 that collectively overrode the negative feedback mechanism glioblastoma hsa-miR-30a-5p RPS6KB1 -0.924084264430689 0.000762030454634728 0.395075168795546 0.000566740506607704 mirMAP;miRNATAP -0.148550414041994 1.43728166295243e-15 NA NA NA hsa-miR-30c-5p RPS6KB1 -0.327319105755825 0.123595832152687 0.395075168795546 0.000566740506607704 mirMAP;miRNATAP -0.17709647899443 3.62948426630194e-13 NA NA NA hsa-miR-342-3p RPS6KB1 -0.128691966564961 0.561034080130801 0.395075168795546 0.000566740506607704 miRanda -0.112495506128509 2.24824143704172e-06 NA NA NA hsa-miR-455-5p RPS6KB1 1.36946341828134 5.05118627562807e-08 0.395075168795546 0.000566740506607704 MirTarget;PITA;miRanda -0.124485509450113 1.60253793337003e-07 NA NA NA hsa-miR-664a-3p RPS6KB1 0.443077463053857 0.0214248925850984 0.395075168795546 0.000566740506607704 MirTarget -0.152855467444993 1.90456092065456e-08 NA NA NA hsa-miR-148a-3p RPTOR 2.30885799126944 1.95226081368985e-21 0.0223491826493696 0.867601962323125 mirMAP -0.110063502594852 4.75721147857351e-06 NA NA NA hsa-miR-326 SGK2 -0.992397386750901 0.00335173765975096 2.33444169458619 9.35291555250327e-07 miRanda -0.218169590716707 0.000818439409068637 NA NA NA hsa-miR-16-2-3p SGK3 0.503964803530872 0.0263648405197492 -0.569272985839165 7.9168273020551e-05 mirMAP -0.112958900853287 0.000400002917071383 NA NA NA hsa-miR-199a-3p SGK3 1.67715607711377 5.96963028176444e-15 -0.569272985839165 7.9168273020551e-05 PITA -0.144635769443984 1.39633607686804e-06 NA NA NA hsa-miR-199a-5p SGK3 1.3057193856884 2.38429382751645e-08 -0.569272985839165 7.9168273020551e-05 miRanda -0.136043149854971 1.11110844834354e-06 NA NA NA hsa-miR-199b-3p SGK3 1.67802185853505 6.03525898173555e-15 -0.569272985839165 7.9168273020551e-05 PITA;miRNATAP -0.144503537008032 1.40408954838629e-06 NA NA NA hsa-miR-590-5p SGK3 2.07441240363458 4.95240551694843e-14 -0.569272985839165 7.9168273020551e-05 PITA;miRanda -0.136781906385094 2.52561809936984e-06 NA NA NA hsa-miR-664a-3p SGK3 0.443077463053857 0.0214248925850984 -0.569272985839165 7.9168273020551e-05 mirMAP -0.126870395220658 0.000254989015477873 NA NA NA hsa-miR-7-1-3p SGK3 2.61364240402652 1.98959237815786e-32 -0.569272985839165 7.9168273020551e-05 mirMAP -0.14130530440915 1.7571392220535e-06 NA NA NA hsa-miR-96-5p SGK3 3.0381097138467 4.40362891630201e-24 -0.569272985839165 7.9168273020551e-05 miRNAWalker2_validate;TargetScan -0.126118919569819 1.72464720627701e-07 NA NA NA hsa-miR-181a-5p SOS1 -0.375429731222937 0.0562142867129802 0.0798852744327974 0.432914353979627 MirTarget;miRNATAP -0.10469236503224 9.69385315635354e-06 NA NA NA hsa-miR-26a-2-3p SOS1 0.264287787772609 0.305653616292982 0.0798852744327974 0.432914353979627 mirMAP -0.11755820325968 1.45592951814447e-07 NA NA NA hsa-miR-30b-5p SOS1 0.358144314839612 0.138026229059594 0.0798852744327974 0.432914353979627 mirMAP -0.100738601906088 1.42009312360891e-07 NA NA NA hsa-miR-30c-5p SOS1 -0.327319105755825 0.123595832152687 0.0798852744327974 0.432914353979627 mirMAP;miRNATAP -0.118113245139624 5.71228815703205e-08 NA NA NA hsa-miR-664a-3p SOS1 0.443077463053857 0.0214248925850984 0.0798852744327974 0.432914353979627 mirMAP -0.10862184907092 6.79471781102034e-06 NA NA NA hsa-miR-139-5p SPP1 -2.26625553116965 7.22375119369519e-16 4.61563851918881 1.35599631950767e-21 miRanda -0.473602076232976 2.29122161191296e-09 NA NA NA hsa-miR-335-5p SPP1 -0.466533891325811 0.0676987038122831 4.61563851918881 1.35599631950767e-21 miRNAWalker2_validate -0.473516574726313 3.22030261769506e-06 NA NA NA hsa-miR-330-3p STK11 -0.716924999893351 0.000796236278616087 -0.155527087747212 0.383462230680077 mirMAP -0.172508913575347 5.88222779025283e-06 NA NA NA hsa-miR-330-5p STK11 0.168520831101569 0.336433937906706 -0.155527087747212 0.383462230680077 miRanda -0.213332537977904 5.28675914606143e-06 NA NA NA hsa-miR-130b-5p SYK 1.53645187062942 1.10498816261505e-08 -0.500099257153372 0.00568976472956072 mirMAP -0.12747244666616 2.75622872975833e-05 NA NA NA hsa-miR-877-5p SYK -0.370234513208225 0.20670834111988 -0.500099257153372 0.00568976472956072 mirMAP -0.145512239592668 2.68111678196671e-07 NA NA NA hsa-miR-92a-3p SYK -0.136362762339122 0.493412263619364 -0.500099257153372 0.00568976472956072 mirMAP -0.110175320627148 0.00900396737172623 NA NA NA hsa-miR-99b-3p SYK -0.0297209462363108 0.884859701321282 -0.500099257153372 0.00568976472956072 miRNAWalker2_validate -0.106451786496213 0.00926501822883302 NA NA NA hsa-miR-421 TEK 0.170525317701774 0.535277026680289 -3.51849633344745 1.22859479372185e-33 miRanda -0.235384971977901 3.52531182065665e-05 NA NA NA hsa-miR-129-5p TGFA -0.405735314747643 0.341485636033577 0.716092021233232 0.0361502264702024 miRanda;mirMAP -0.121124296234011 0.00108133059542916 NA NA NA hsa-miR-326 TGFA -0.992397386750901 0.00335173765975096 0.716092021233232 0.0361502264702024 miRanda -0.194754872845494 2.44496930317185e-05 NA NA NA hsa-miR-330-5p TGFA 0.168520831101569 0.336433937906706 0.716092021233232 0.0361502264702024 miRanda -0.444525202951942 7.55981323762078e-07 NA NA NA hsa-miR-92a-3p TGFA -0.136362762339122 0.493412263619364 0.716092021233232 0.0361502264702024 miRNAWalker2_validate -0.363824944890668 4.2136374441386e-06 NA NA NA hsa-miR-16-1-3p THBS1 1.50034693398929 6.63958242991125e-10 -0.930928104430071 0.00139531304277658 MirTarget -0.335212349500693 6.0842815757812e-07 NA NA NA hsa-miR-17-5p THBS1 2.07078488653279 2.77403038572568e-19 -0.930928104430071 0.00139531304277658 miRNAWalker2_validate -0.438129032548489 9.5201094057219e-16 NA NA NA hsa-miR-182-5p THBS1 3.21839823004635 5.13049145201115e-39 -0.930928104430071 0.00139531304277658 MirTarget -0.17203897957724 0.000598074099312019 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-186-5p THBS1 0.852175445703945 6.88885738584309e-10 -0.930928104430071 0.00139531304277658 mirMAP -0.519985070059 6.04454698272776e-08 NA NA NA hsa-miR-18a-5p THBS1 1.37435209536521 9.2173853686829e-06 -0.930928104430071 0.00139531304277658 MirTarget -0.297317863017191 9.33481417958521e-11 NA NA NA hsa-miR-19a-3p THBS1 2.11776595911517 7.07663078397156e-10 -0.930928104430071 0.00139531304277658 MirTarget;mirMAP -0.320107454551527 1.0910865655915e-12 NA NA NA hsa-miR-19b-3p THBS1 2.10868505662119 5.40846613768389e-17 -0.930928104430071 0.00139531304277658 MirTarget;mirMAP -0.394071669543936 1.30352702952378e-13 NA NA NA hsa-miR-200a-5p THBS1 2.26680634475411 1.52168554660094e-17 -0.930928104430071 0.00139531304277658 MirTarget -0.192969334171335 7.36724513214628e-05 NA NA NA hsa-miR-200b-5p THBS1 0.5652412449293 0.0273948420835934 -0.930928104430071 0.00139531304277658 MirTarget -0.190414406051537 0.000286594153768624 NA NA NA hsa-miR-20a-5p THBS1 2.64649625616975 5.1469418982085e-27 -0.930928104430071 0.00139531304277658 miRNAWalker2_validate -0.389697563087682 9.68073828210161e-15 NA NA NA hsa-miR-29b-1-5p THBS1 1.71024742617744 3.64915691793611e-09 -0.930928104430071 0.00139531304277658 mirMAP -0.174722185271877 0.000124277285903 NA NA NA hsa-miR-3065-5p THBS1 0.653308707552535 0.0999497219778851 -0.930928104430071 0.00139531304277658 MirTarget -0.146963541534871 6.23555676304228e-05 NA NA NA hsa-miR-32-5p THBS1 0.876853679269853 6.04859399018691e-05 -0.930928104430071 0.00139531304277658 mirMAP -0.378697285956757 8.57166070787422e-09 NA NA NA hsa-miR-335-3p THBS1 1.51116383169018 6.88553098788624e-13 -0.930928104430071 0.00139531304277658 mirMAP -0.277769513126927 8.06336576747616e-06 NA NA NA hsa-miR-338-3p THBS1 0.726843067232002 0.0506251324215494 -0.930928104430071 0.00139531304277658 MirTarget;PITA;miRanda -0.137206796252208 0.000139893109055389 NA NA NA hsa-miR-500a-5p THBS1 0.648155655714409 0.0104657432932038 -0.930928104430071 0.00139531304277658 mirMAP -0.266623772340649 8.55185956464653e-07 NA NA NA hsa-miR-576-5p THBS1 1.02693643167056 1.14846964470173e-06 -0.930928104430071 0.00139531304277658 mirMAP -0.283940645214832 6.42767093777526e-06 NA NA NA hsa-miR-590-3p THBS1 0.83851360565783 0.00129224433453587 -0.930928104430071 0.00139531304277658 miRanda -0.190498848920156 0.00206214930389577 NA NA NA hsa-miR-590-5p THBS1 2.07441240363458 4.95240551694843e-14 -0.930928104430071 0.00139531304277658 miRanda;mirMAP -0.246253114774633 2.83321183197093e-05 NA NA NA hsa-miR-664a-3p THBS1 0.443077463053857 0.0214248925850984 -0.930928104430071 0.00139531304277658 mirMAP -0.228448076947888 0.00112527165905494 NA NA NA hsa-miR-671-5p THBS1 2.24156654191798 2.10433241567652e-14 -0.930928104430071 0.00139531304277658 MirTarget -0.190134986140565 0.000356438440186681 NA NA NA hsa-miR-7-1-3p THBS1 2.61364240402652 1.98959237815786e-32 -0.930928104430071 0.00139531304277658 MirTarget;mirMAP -0.299067024820193 5.25045592977195e-07 NA NA NA hsa-miR-92a-3p THBS1 -0.136362762339122 0.493412263619364 -0.930928104430071 0.00139531304277658 miRNAWalker2_validate -0.339440045365484 4.84769739541811e-07 NA NA NA hsa-miR-106a-5p THBS2 1.3902608059488 6.07931522284525e-05 2.13303340663678 5.55214196969225e-10 MirTarget -0.141118825069235 0.00632866362209016 NA NA NA hsa-miR-139-5p THBS2 -2.26625553116965 7.22375119369519e-16 2.13303340663678 5.55214196969225e-10 miRanda -0.328833798121345 1.9873453443232e-09 NA NA NA hsa-miR-16-2-3p THBS2 0.503964803530872 0.0263648405197492 2.13303340663678 5.55214196969225e-10 mirMAP -0.269836760400924 0.000475097739448551 NA NA NA hsa-miR-29a-3p THBS2 0.101650412194573 0.573201097011668 2.13303340663678 5.55214196969225e-10 MirTarget -0.324285863811433 0.000313287451075819 NA NA NA hsa-miR-320a THBS2 -0.961144925954715 1.62478794429204e-08 2.13303340663678 5.55214196969225e-10 mirMAP -0.27353755909077 0.00366923961047422 NA NA NA hsa-miR-3614-5p THBS2 -1.19394699210224 2.53933783780868e-05 2.13303340663678 5.55214196969225e-10 miRNATAP -0.322232683205048 8.12599690622336e-09 NA NA NA hsa-miR-598-3p THBS2 -0.213242160655447 0.368994149341807 2.13303340663678 5.55214196969225e-10 MirTarget -0.193388031380303 0.00459994901259022 NA NA NA hsa-miR-330-5p THBS3 0.168520831101569 0.336433937906706 0.549487093763986 0.000601149234716636 PITA;miRNATAP -0.112644167678696 0.00816796162850372 NA NA NA hsa-miR-335-5p THBS3 -0.466533891325811 0.0676987038122831 0.549487093763986 0.000601149234716636 miRNAWalker2_validate -0.141776297937504 1.12055228143462e-05 NA NA NA hsa-miR-423-5p THBS3 -1.80309342242719 1.34791344187441e-19 0.549487093763986 0.000601149234716636 PITA;miRNATAP -0.142789815887308 6.20874730755168e-05 NA NA NA hsa-miR-550a-5p THBS3 0.59977150019756 0.0314775340172755 0.549487093763986 0.000601149234716636 MirTarget -0.106893380207728 5.35877569139196e-05 NA NA NA hsa-miR-320b THBS4 0.226640952564488 0.378818692487242 0.207986637703878 0.71062132013972 miRanda -0.402754134240922 5.6138965380905e-05 NA NA NA hsa-miR-106b-5p TLR2 1.47447672652218 1.32004094930462e-13 -1.05534320441046 0.000222892587166564 miRNAWalker2_validate -0.533217811215797 2.15747763973276e-17 NA NA NA hsa-miR-19a-3p TLR2 2.11776595911517 7.07663078397156e-10 -1.05534320441046 0.000222892587166564 miRNAWalker2_validate;miRTarBase -0.307198760388121 3.93094762257097e-12 NA NA NA hsa-miR-19b-3p TLR2 2.10868505662119 5.40846613768389e-17 -1.05534320441046 0.000222892587166564 miRNAWalker2_validate;miRTarBase -0.240602341675931 6.29198231521274e-06 NA NA NA hsa-miR-320b TLR2 0.226640952564488 0.378818692487242 -1.05534320441046 0.000222892587166564 miRanda -0.291198435748237 1.04073377036224e-08 NA NA NA hsa-miR-590-3p TLR2 0.83851360565783 0.00129224433453587 -1.05534320441046 0.000222892587166564 miRanda -0.288602076304715 1.7352978926031e-06 NA NA NA hsa-miR-107 TLR4 0.658676029898313 5.11480446318819e-07 -2.06259897319771 8.13416542428308e-17 miRanda -0.350734478487099 9.93425020062718e-05 NA NA NA hsa-miR-1287-5p TLR4 0.84044583303753 0.000159851902447422 -2.06259897319771 8.13416542428308e-17 MirTarget -0.225778851636167 1.76643511851113e-05 NA NA NA hsa-miR-17-5p TLR4 2.07078488653279 2.77403038572568e-19 -2.06259897319771 8.13416542428308e-17 TargetScan -0.402841711273338 2.78311838182334e-17 NA NA NA hsa-miR-21-5p TLR4 4.38165933891779 1.52536633902505e-92 -2.06259897319771 8.13416542428308e-17 miRNAWalker2_validate -0.310015993716253 1.78751167789183e-12 27286259 For in vivo relevance expression of TLR4 was correlated with miR-21 expression and ROS production in freshly isolated untreated primary human lung cancer cells lung cancer hsa-miR-331-5p TLR4 0.578237334664505 0.00131211239210882 -2.06259897319771 8.13416542428308e-17 MirTarget -0.380506566615217 1.16014194400498e-08 NA NA NA hsa-miR-542-3p TLR4 1.62226640768239 2.6427102465476e-10 -2.06259897319771 8.13416542428308e-17 miRanda -0.156562978211316 0.000512202589629934 NA NA NA hsa-miR-590-5p TLR4 2.07441240363458 4.95240551694843e-14 -2.06259897319771 8.13416542428308e-17 miRanda -0.291755575372718 1.17844773010688e-08 NA NA NA hsa-miR-7-1-3p TLR4 2.61364240402652 1.98959237815786e-32 -2.06259897319771 8.13416542428308e-17 mirMAP -0.318870899906122 8.14289623480692e-10 NA NA NA hsa-miR-129-5p TNC -0.405735314747643 0.341485636033577 0.57965298093833 0.171283129464553 miRanda -0.187596516094653 4.1052565839279e-05 NA NA NA hsa-miR-330-3p TNC -0.716924999893351 0.000796236278616087 0.57965298093833 0.171283129464553 MirTarget -0.310850868827245 0.00063939941426808 NA NA NA hsa-miR-330-5p TNC 0.168520831101569 0.336433937906706 0.57965298093833 0.171283129464553 MirTarget;miRanda;miRNATAP -0.471873860124968 2.38473728160081e-05 NA NA NA hsa-miR-335-5p TNC -0.466533891325811 0.0676987038122831 0.57965298093833 0.171283129464553 miRNAWalker2_validate;miRTarBase -0.37131762732385 1.29415699469758e-05 NA NA NA hsa-miR-501-5p TNC 0.411357595674671 0.10435288464149 0.57965298093833 0.171283129464553 miRNATAP -0.305491650553852 7.02294431676545e-05 NA NA NA hsa-miR-141-3p TNR 3.36993755486106 5.42939251147195e-32 -3.09410842268176 4.37988239967698e-14 TargetScan -0.340672795559202 5.14526658344645e-08 NA NA NA hsa-miR-542-3p TNR 1.62226640768239 2.6427102465476e-10 -3.09410842268176 4.37988239967698e-14 miRanda -0.30687476658953 3.32701697343745e-05 NA NA NA hsa-miR-7-1-3p TNR 2.61364240402652 1.98959237815786e-32 -3.09410842268176 4.37988239967698e-14 MirTarget -0.344669258508342 6.65794621615439e-05 NA NA NA hsa-miR-1301-3p TNXB 0.845987603184611 0.000579808501723616 -3.50107711061625 8.17693906061985e-20 miRNAWalker2_validate -0.486260344346074 3.6516837097481e-11 NA NA NA hsa-miR-3607-3p TNXB 2.4103172144469 2.69039449048047e-08 -3.50107711061625 8.17693906061985e-20 miRNATAP -0.159959344634277 0.000126845264934311 NA NA NA hsa-miR-10a-5p TSC1 0.790595816051606 0.000593731378445468 -0.0968330404675113 0.413738925573725 mirMAP -0.107998315623831 3.80321635664832e-06 NA NA NA hsa-miR-1-3p VEGFA -1.48412019995919 0.000242034342580425 0.230749341603949 0.311300638391058 MirTarget -0.172921089301484 3.76698090411866e-10 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-101-3p VEGFA 1.38889039459232 1.96522549511542e-09 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.184546125824104 3.21659312920503e-05 NA NA NA hsa-miR-125a-3p VEGFA -1.04954492275266 2.45974219476832e-06 0.230749341603949 0.311300638391058 miRanda -0.155505773345232 0.000854677712414177 22768249 Ectopic expression of MiR 125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF; Furthermore miR-125a expression was inversely correlated with both MMP11 and VEGF-A expression in HCC tissues; MiR-125a inhibits the proliferation and metastasis of HCC by targeting MMP11 and VEGF-A metastasis liver cancer hsa-miR-133a-3p VEGFA -2.89609207852024 1.71222048144972e-13 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.104720990536239 5.4001689907379e-05 NA NA NA hsa-miR-140-5p VEGFA 0.669142684153918 0.000335928403032308 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.246162039129829 1.79001025551982e-05 26402430 MicroRNA 140 5p inhibits the progression of colorectal cancer by targeting VEGFA; The direct regulation of VEGFA by miR-140-5p was identified using luciferase reporter assay; Integrated analysis identified VEGFA as a direct and functional target gene of miR-140-5p; Silencing VEGFA by small interfering RNA siRNA resembled the phenotype resulting from ectopic miR-140-5p expression while overexpression of VEGFA attenuated the effect of miR-140-5p on CRC cells; Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA progression;tumorigenesis colorectal cancer hsa-miR-150-5p VEGFA -0.702328520623782 0.0215316651134431 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase -0.211938415847961 3.12072029375035e-10 NA NA NA hsa-miR-195-5p VEGFA -1.01577502605386 4.80814718341729e-05 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget -0.216253591570711 7.05557590450539e-07 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-29c-3p VEGFA 1.32354490728858 1.84279305179762e-07 0.230749341603949 0.311300638391058 miRNAWalker2_validate;MirTarget -0.189793475587463 2.81724907347383e-06 NA NA NA hsa-miR-330-3p VEGFA -0.716924999893351 0.000796236278616087 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.385541553437526 4.9599607016426e-16 NA NA NA hsa-miR-335-5p VEGFA -0.466533891325811 0.0676987038122831 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.139733266743143 0.00237085343344445 NA NA NA hsa-miR-361-5p VEGFA 0.21454431962475 0.0800957579368424 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.311546652005902 0.000341919545726308 NA NA NA hsa-miR-374a-3p VEGFA 1.73882813668241 1.57901646296214e-13 0.230749341603949 0.311300638391058 MirTarget -0.116308302225143 0.0073756212717737 23679262 Our data demonstrated miR-374a to be differentially distributed in breast cancer; VEGF-A and VCAM-1 mRNA had coincident distribution and the distribution of teh respective proteins was uneven and opposite to that for the miR-374a breast cancer hsa-miR-374a-5p VEGFA -0.197027254874826 0.298080902192861 0.230749341603949 0.311300638391058 MirTarget -0.195164100931073 0.0017653451750918 23679262 Our data demonstrated miR-374a to be differentially distributed in breast cancer; VEGF-A and VCAM-1 mRNA had coincident distribution and the distribution of teh respective proteins was uneven and opposite to that for the miR-374a breast cancer hsa-miR-374b-5p VEGFA 0.474691035780475 0.0109217471394203 0.230749341603949 0.311300638391058 MirTarget -0.165654325982956 0.00541935782229369 NA NA NA hsa-miR-378a-3p VEGFA -2.0140903990983 1.146745431034e-18 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase -0.188122556602091 1.9053920640873e-05 NA NA NA hsa-miR-15a-5p VWF 1.62575353599172 1.55312121019827e-19 -2.80037755667176 6.6145036112199e-24 mirMAP -0.397551457387971 2.65369738906546e-08 NA NA NA hsa-miR-16-5p VWF 0.749619098384047 4.11649450706988e-06 -2.80037755667176 6.6145036112199e-24 mirMAP -0.345255830894533 2.73135093957602e-05 NA NA NA hsa-miR-424-5p VWF 1.26485330287919 6.1498991028257e-06 -2.80037755667176 6.6145036112199e-24 mirMAP -0.308297400793499 4.66290246108594e-11 NA NA NA hsa-miR-429 VWF 2.3794516574089 1.72813419703734e-13 -2.80037755667176 6.6145036112199e-24 miRNATAP -0.212161134463217 1.17920516055928e-06 NA NA NA hsa-miR-146b-5p YWHAE 1.0922867893808 5.63754607494775e-06 -0.162345608104685 0.146274876044794 miRanda -0.111814411639533 8.76763789112146e-08 NA NA NA hsa-miR-155-5p YWHAE 0.813513839059142 0.000608282725633232 -0.162345608104685 0.146274876044794 MirTarget;miRNATAP -0.123012732065191 6.9279077580742e-09 NA NA NA hsa-miR-199a-5p YWHAE 1.3057193856884 2.38429382751645e-08 -0.162345608104685 0.146274876044794 miRanda -0.148964380915099 1.85988470639596e-12 NA NA NA hsa-miR-199b-5p YWHAE 2.13822205171062 4.56262988762436e-15 -0.162345608104685 0.146274876044794 miRanda -0.120520769429681 1.48491231495563e-11 NA NA NA hsa-miR-139-5p YWHAG -2.26625553116965 7.22375119369519e-16 0.440821980058659 0.00101832071918287 MirTarget;PITA;miRanda;miRNATAP -0.127495400492206 1.2727841918362e-09 NA NA NA hsa-miR-140-3p YWHAG -1.11373309124537 8.35257079443689e-14 0.440821980058659 0.00101832071918287 MirTarget;PITA;miRNATAP -0.306652373379445 1.11890284888968e-14 NA NA NA hsa-miR-181a-5p YWHAG -0.375429731222937 0.0562142867129802 0.440821980058659 0.00101832071918287 MirTarget;miRNATAP -0.173505222876932 2.79310441800563e-08 NA NA NA hsa-miR-181c-5p YWHAG 0.529875814537156 0.0125885822998008 0.440821980058659 0.00101832071918287 MirTarget;miRNATAP -0.170024749920434 3.49311586517858e-09 NA NA NA hsa-miR-200a-3p YWHAG 3.14766878548496 1.32850889777422e-21 0.440821980058659 0.00101832071918287 MirTarget;miRNATAP -0.112404756335661 5.04076550847479e-10 NA NA NA hsa-miR-200b-3p YWHAG 1.55157578247391 4.83790020897188e-09 0.440821980058659 0.00101832071918287 MirTarget;TargetScan -0.13160534442703 6.40730407184039e-09 NA NA NA hsa-miR-30a-5p YWHAG -0.924084264430689 0.000762030454634728 0.440821980058659 0.00101832071918287 miRNATAP -0.201085222503192 1.00065004288776e-20 NA NA NA hsa-miR-30b-5p YWHAG 0.358144314839612 0.138026229059594 0.440821980058659 0.00101832071918287 miRNATAP -0.181888404617956 4.18015678029477e-13 NA NA NA hsa-miR-30c-5p YWHAG -0.327319105755825 0.123595832152687 0.440821980058659 0.00101832071918287 miRNATAP -0.253949498332365 1.69959478903248e-19 NA NA NA hsa-miR-30d-5p YWHAG -0.920901858717441 3.50898334321668e-05 0.440821980058659 0.00101832071918287 miRNATAP -0.235001527999773 1.27841332129965e-18 NA NA NA hsa-miR-30e-5p YWHAG 1.60414100786743 3.78951090573667e-19 0.440821980058659 0.00101832071918287 miRNATAP -0.166831106737098 4.41822966338321e-07 NA NA NA hsa-miR-320a YWHAG -0.961144925954715 1.62478794429204e-08 0.440821980058659 0.00101832071918287 PITA;miRanda;miRNATAP -0.138044013407694 0.000124028645415388 NA NA NA hsa-miR-342-3p YWHAG -0.128691966564961 0.561034080130801 0.440821980058659 0.00101832071918287 miRanda -0.112708260763668 5.54327050620456e-05 NA NA NA hsa-miR-361-3p YWHAG 0.0988926195529967 0.549128728500555 0.440821980058659 0.00101832071918287 miRNATAP -0.180828220753678 1.49095137215055e-06 NA NA NA hsa-miR-500a-5p YWHAG 0.648155655714409 0.0104657432932038 0.440821980058659 0.00101832071918287 MirTarget;miRNATAP -0.116956873840769 2.67083784348092e-06 NA NA NA hsa-miR-103a-3p YWHAH 0.538497806383155 1.88134691850591e-05 -0.232507548831896 0.0270772293659851 miRNAWalker2_validate;MirTarget;miRNATAP -0.203453716772227 1.0945341693782e-07 NA NA NA hsa-miR-107 YWHAH 0.658676029898313 5.11480446318819e-07 -0.232507548831896 0.0270772293659851 MirTarget;PITA;miRanda;miRNATAP -0.11083014392296 0.00269449165913979 NA NA NA hsa-miR-186-5p YWHAH 0.852175445703945 6.88885738584309e-10 -0.232507548831896 0.0270772293659851 miRNAWalker2_validate -0.195720652925808 1.17969368044911e-08 NA NA NA hsa-miR-324-5p YWHAH 1.06955541886548 5.39722006604758e-05 -0.232507548831896 0.0270772293659851 miRNAWalker2_validate -0.1101263094924 6.33335452195712e-10 NA NA NA hsa-miR-139-5p YWHAQ -2.26625553116965 7.22375119369519e-16 0.167770822857293 0.149541644649826 MirTarget;PITA;miRanda;miRNATAP -0.125565430539164 3.05602665873019e-12 NA NA NA hsa-miR-145-3p YWHAQ -0.68545633476888 0.000680820366475469 0.167770822857293 0.149541644649826 MirTarget;miRNATAP -0.172660588094719 2.86041381730263e-11 NA NA NA hsa-miR-15a-5p YWHAQ 1.62575353599172 1.55312121019827e-19 0.167770822857293 0.149541644649826 MirTarget;miRNATAP -0.103636165558495 0.000288131949373333 NA NA NA hsa-miR-200b-3p YWHAQ 1.55157578247391 4.83790020897188e-09 0.167770822857293 0.149541644649826 TargetScan -0.103114978597469 1.46440567065747e-07 NA NA NA hsa-miR-27a-3p YWHAQ 0.433402568013802 0.00737164631768323 0.167770822857293 0.149541644649826 MirTarget -0.114218331322201 0.000575063051743503 NA NA NA hsa-miR-27b-3p YWHAQ 0.236438984240408 0.12263510345883 0.167770822857293 0.149541644649826 MirTarget -0.127095716424262 0.000300405629060681 NA NA NA hsa-miR-320a YWHAQ -0.961144925954715 1.62478794429204e-08 0.167770822857293 0.149541644649826 MirTarget;PITA;miRanda;miRNATAP -0.170752732171646 2.8347653578931e-08 NA NA NA hsa-miR-497-5p YWHAQ -0.0546347378264729 0.786205564901684 0.167770822857293 0.149541644649826 MirTarget;miRNATAP -0.243634757664687 1.35163778783183e-21 NA NA NA hsa-let-7b-5p YWHAZ -1.62016148171663 1.56547487335694e-15 0.742048268483137 1.17639688533012e-07 miRNAWalker2_validate -0.16430584605795 1.03419318175904e-07 NA NA NA hsa-miR-125a-5p YWHAZ -1.04824536696301 3.97386082850476e-07 0.742048268483137 1.17639688533012e-07 miRanda -0.237020763887747 6.87766229457755e-15 NA NA NA hsa-miR-140-3p YWHAZ -1.11373309124537 8.35257079443689e-14 0.742048268483137 1.17639688533012e-07 MirTarget;PITA;miRNATAP -0.391596646798971 1.8940405019791e-21 NA NA NA hsa-miR-186-5p YWHAZ 0.852175445703945 6.88885738584309e-10 0.742048268483137 1.17639688533012e-07 mirMAP -0.152208595579121 0.00118572329862627 NA NA NA hsa-miR-195-3p YWHAZ -1.33068822339418 6.65427393047357e-09 0.742048268483137 1.17639688533012e-07 MirTarget -0.222495897728137 3.41482438203482e-16 NA NA NA hsa-miR-30a-5p YWHAZ -0.924084264430689 0.000762030454634728 0.742048268483137 1.17639688533012e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.201186598647973 1.15722338635181e-18 NA NA NA hsa-miR-30c-5p YWHAZ -0.327319105755825 0.123595832152687 0.742048268483137 1.17639688533012e-07 MirTarget;miRNATAP -0.288739774257498 9.48887811222695e-23 24519092 Involvement of miR 30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells; Together our findings provided evidence that miR-30c was one of the important miRNAs in doxorubicin resistance by regulating YWHAZ in the breast cancer cell line MCF-7/ADR drug resistance breast cancer hsa-miR-30d-5p YWHAZ -0.920901858717441 3.50898334321668e-05 0.742048268483137 1.17639688533012e-07 MirTarget;miRNATAP -0.141642518231123 9.75824254047956e-07 NA NA NA hsa-miR-30e-5p YWHAZ 1.60414100786743 3.78951090573667e-19 0.742048268483137 1.17639688533012e-07 MirTarget;miRNATAP -0.121458978508407 0.000533900032886707 NA NA NA hsa-miR-320a YWHAZ -0.961144925954715 1.62478794429204e-08 0.742048268483137 1.17639688533012e-07 MirTarget;PITA;miRanda;miRNATAP -0.157423933177928 3.20781580410077e-05 NA NA NA hsa-miR-328-3p YWHAZ -0.971820898675371 0.000667255504710486 0.742048268483137 1.17639688533012e-07 MirTarget -0.124104498406864 3.32290942379795e-08 NA NA NA hsa-miR-484 YWHAZ -0.228576985124486 0.244112867390855 0.742048268483137 1.17639688533012e-07 miRNAWalker2_validate -0.116171758391268 0.000497835813356803 NA NA NA hsa-miR-664a-3p YWHAZ 0.443077463053857 0.0214248925850984 0.742048268483137 1.17639688533012e-07 mirMAP -0.262638767629816 1.83967801674611e-15 NA NA NA