miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-107 ACVR1 0.241662461253461 0.0170788899505389 -0.436041316598948 1.42037811134341e-05 miRanda -0.197266590242364 5.29881536306391e-05 NA NA NA hsa-miR-148a-3p ACVR1 -0.748702855596996 3.93313343865641e-07 -0.436041316598948 1.42037811134341e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.127757812095218 0.000102607735840908 NA NA NA hsa-miR-362-3p ACVR1 0.814007335895913 2.00108618836568e-09 -0.436041316598948 1.42037811134341e-05 miRanda -0.1581047137595 8.41477701013854e-06 NA NA NA hsa-let-7d-5p ACVR1C 0.0503292020123807 0.702580311853671 -2.19871896765337 7.84657232630462e-19 MirTarget;miRNATAP -0.467124977184397 1.03044182442353e-06 NA NA NA hsa-let-7e-5p ACVR1C 0.0350298755544731 0.811068614727804 -2.19871896765337 7.84657232630462e-19 MirTarget;miRNATAP -0.469898371810305 3.95921292985298e-08 NA NA NA hsa-let-7i-5p ACVR1C -0.14267936165213 0.154141689875847 -2.19871896765337 7.84657232630462e-19 MirTarget;miRNATAP -0.356758393437739 0.0052062465540518 NA NA NA hsa-miR-181a-5p ACVR1C 0.250113435902954 0.0551933249319293 -2.19871896765337 7.84657232630462e-19 miRNATAP -0.670634770966393 1.62470917032778e-12 NA NA NA hsa-miR-181b-5p ACVR1C 0.488256489401108 0.00105321129419701 -2.19871896765337 7.84657232630462e-19 miRNATAP -0.665132657201591 4.28032049160444e-16 NA NA NA hsa-miR-181c-5p ACVR1C -0.00639394152050299 0.969127212255928 -2.19871896765337 7.84657232630462e-19 miRNATAP -0.458081606281759 1.29011415864451e-09 NA NA NA hsa-miR-200b-3p ACVR1C -1.29335788099229 0.000268623234305059 -2.19871896765337 7.84657232630462e-19 TargetScan -0.183007107086886 1.58925342765656e-07 NA NA NA hsa-miR-330-3p ACVR1C -0.332364259424489 0.0316051913061459 -2.19871896765337 7.84657232630462e-19 MirTarget -0.198151785883519 0.0181357314561159 NA NA NA hsa-miR-331-5p ACVR1C 0.213759185384356 0.120772399478646 -2.19871896765337 7.84657232630462e-19 miRNATAP -0.34574070535444 0.000180556254125148 NA NA NA hsa-miR-409-3p ACVR1C -0.499649792570937 0.0526751181520117 -2.19871896765337 7.84657232630462e-19 MirTarget -0.10171007159956 0.0381045111036601 NA NA NA hsa-miR-429 ACVR1C -1.40262535827285 6.93982219171912e-05 -2.19871896765337 7.84657232630462e-19 PITA;miRanda;miRNATAP -0.166099197592482 3.26640838011068e-06 NA NA NA hsa-miR-98-5p ACVR1C -0.0487189107419432 0.715911066732548 -2.19871896765337 7.84657232630462e-19 MirTarget -0.405044635870102 1.7888202448194e-05 NA NA NA hsa-miR-185-5p ACVR2A 0.480006257154717 6.35758891340152e-07 -0.549017310001321 8.35009567429434e-13 miRNATAP -0.16965657903652 1.65499147511686e-05 NA NA NA hsa-miR-188-5p ACVR2A 1.11646899351496 9.56686958408598e-11 -0.549017310001321 8.35009567429434e-13 PITA -0.133720253233932 3.90394281540616e-10 NA NA NA hsa-miR-21-5p ACVR2A 1.51084295924322 1.54551622173259e-34 -0.549017310001321 8.35009567429434e-13 miRNATAP -0.169607048854855 1.73814737029117e-09 NA NA NA hsa-let-7b-3p ACVR2B -1.21979213547786 5.84575581584603e-17 -0.241187869117871 0.055027969077237 MirTarget -0.167205940939797 3.26059886622021e-05 NA NA NA hsa-miR-140-3p ACVR2B 0.546012239205329 4.84578261098777e-11 -0.241187869117871 0.055027969077237 miRNAWalker2_validate;PITA;miRNATAP -0.229562524043511 0.00167264911908694 NA NA NA hsa-miR-32-3p BMP2 0.219109440121582 0.207217051619543 -0.181847824396152 0.359108207280307 mirMAP -0.13648933584318 0.0177514178931512 NA NA NA hsa-miR-142-3p BMP4 -1.4243101967815 1.92609481097765e-14 0.756049865330478 0.00257381502256996 PITA;miRanda -0.207247600922499 0.00115116569048984 NA NA NA hsa-miR-590-3p BMP4 -0.473167498047808 1.76652934637227e-05 0.756049865330478 0.00257381502256996 miRanda -0.268712016713412 0.0157696610131182 NA NA NA hsa-miR-130b-3p BMP6 0.687190305027546 0.000109068658562255 -1.04070882636827 2.86680404280335e-07 MirTarget -0.261586357774358 2.54168454737691e-06 NA NA NA hsa-miR-301a-3p BMP6 0.842910511640361 1.43446467417891e-06 -1.04070882636827 2.86680404280335e-07 MirTarget -0.142411515985238 0.0120618957133615 NA NA NA hsa-miR-362-3p BMP6 0.814007335895913 2.00108618836568e-09 -1.04070882636827 2.86680404280335e-07 miRanda -0.295803453331868 4.29317836105299e-05 NA NA NA hsa-miR-454-3p BMP6 0.668749059573955 2.42670710515113e-06 -1.04070882636827 2.86680404280335e-07 MirTarget -0.221282179224421 0.0015666342787123 NA NA NA hsa-miR-130b-5p BMP7 0.170599813152408 0.337611586432771 0.826802462156244 0.0488671273441991 mirMAP -0.318132163788707 0.00583072092537794 NA NA NA hsa-miR-1976 BMP7 -0.431472440543166 0.00324575010550946 0.826802462156244 0.0488671273441991 MirTarget -0.453184137513286 0.0011534801443726 NA NA NA hsa-miR-22-3p BMP7 -0.628561621952407 1.33755558015523e-09 0.826802462156244 0.0488671273441991 miRNAWalker2_validate;miRTarBase -0.870526640067938 7.19988594035658e-06 NA NA NA hsa-miR-30a-5p BMP7 -0.626257932887855 0.000108198196973765 0.826802462156244 0.0488671273441991 mirMAP;miRNATAP -0.347549267695056 0.00579249244441942 NA NA NA hsa-miR-30e-5p BMP7 -0.627815042856657 3.02205690184908e-10 0.826802462156244 0.0488671273441991 mirMAP -0.577684399384162 0.00443944182643628 NA NA NA hsa-miR-34a-5p BMP7 1.03694231790865 5.74864019540594e-14 0.826802462156244 0.0488671273441991 miRNAWalker2_validate -0.454356184389064 0.00161959499114198 NA NA NA hsa-miR-616-5p BMP7 0.150569904638223 0.402836556304524 0.826802462156244 0.0488671273441991 mirMAP -0.332806313369365 0.00359782816716627 NA NA NA hsa-miR-140-5p BMP8A -0.220106443070144 0.0140713197101242 1.39179535627051 2.07768362972566e-10 miRanda -0.291549744259201 0.0181314706442753 NA NA NA hsa-miR-146b-5p BMP8A 0.419719546795449 0.0457375823220155 1.39179535627051 2.07768362972566e-10 miRanda -0.120676087827195 0.020239063262763 NA NA NA hsa-miR-194-3p BMP8A -0.772747277805343 2.9537465170191e-05 1.39179535627051 2.07768362972566e-10 MirTarget -0.345321516579304 1.96255802091214e-09 NA NA NA hsa-miR-30b-3p BMP8A -0.439724365151373 0.000947180503583586 1.39179535627051 2.07768362972566e-10 MirTarget -0.25070018143597 0.00221524890746471 NA NA NA hsa-miR-30e-3p BMP8A -1.20845647373031 3.10263633528203e-25 1.39179535627051 2.07768362972566e-10 MirTarget -0.31816745204753 0.000320409945817414 NA NA NA hsa-miR-455-5p BMP8A -0.270546034117157 0.0581320703577731 1.39179535627051 2.07768362972566e-10 MirTarget;miRanda -0.220675062526455 0.00398165917143642 NA NA NA hsa-miR-107 BMP8B 0.241662461253461 0.0170788899505389 0.278635309161162 0.41783156155133 mirMAP -0.328048269297664 0.0495962392693521 NA NA NA hsa-miR-33a-5p BMP8B -0.767474460958522 1.09948756118522e-05 0.278635309161162 0.41783156155133 mirMAP -0.197887001543301 0.0378765833159468 NA NA NA hsa-miR-618 BMP8B 0.13539895350352 0.517145913114103 0.278635309161162 0.41783156155133 mirMAP -0.24421376667831 0.00327620044478589 NA NA NA hsa-miR-140-5p BMPR1A -0.220106443070144 0.0140713197101242 0.067404757264657 0.485036666167898 miRanda -0.151764440750276 0.00409272631734622 NA NA NA hsa-miR-130b-3p BMPR1B 0.687190305027546 0.000109068658562255 -3.30804269912471 8.81244453798961e-22 miRNATAP -0.344947495172456 0.000487754390390581 NA NA NA hsa-miR-140-3p BMPR1B 0.546012239205329 4.84578261098777e-11 -3.30804269912471 8.81244453798961e-22 MirTarget -1.09046911115585 1.89877766089125e-07 NA NA NA hsa-miR-362-3p BMPR1B 0.814007335895913 2.00108618836568e-09 -3.30804269912471 8.81244453798961e-22 MirTarget;miRanda -0.645914455969268 3.79800689680595e-07 NA NA NA hsa-miR-374a-5p BMPR1B 0.016390363747302 0.869784217438621 -3.30804269912471 8.81244453798961e-22 MirTarget -0.964921957092298 5.09264356359135e-08 NA NA NA hsa-miR-374b-5p BMPR1B -0.307538028546424 0.0030079617545972 -3.30804269912471 8.81244453798961e-22 MirTarget -0.450695839099619 0.00881847978065475 NA NA NA hsa-miR-421 BMPR1B 0.941856334694081 6.12167297054077e-08 -3.30804269912471 8.81244453798961e-22 miRanda -0.245917894142299 0.0148320277808556 NA NA NA hsa-miR-106b-5p BMPR2 0.648901865047099 8.24870862047885e-09 -0.735692104466334 2.00485450351153e-12 MirTarget;miRNATAP -0.223512431560996 8.9188830870315e-07 NA NA NA hsa-miR-130b-3p BMPR2 0.687190305027546 0.000109068658562255 -0.735692104466334 2.00485450351153e-12 MirTarget;miRNATAP -0.123929624069971 2.01446000231601e-05 NA NA NA hsa-miR-148b-3p BMPR2 0.266862251671911 0.00185271302045935 -0.735692104466334 2.00485450351153e-12 mirMAP -0.274706970733769 7.21649363049453e-06 NA NA NA hsa-miR-17-5p BMPR2 0.698861147045461 2.43854106455398e-05 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.258030480679531 1.14307562421225e-17 NA NA NA hsa-miR-185-5p BMPR2 0.480006257154717 6.35758891340152e-07 -0.735692104466334 2.00485450351153e-12 MirTarget -0.248251149962323 3.7820744273094e-06 NA NA NA hsa-miR-19a-3p BMPR2 1.01712596153672 2.57753201450625e-07 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.171941398552025 1.65410472584267e-11 NA NA NA hsa-miR-19b-3p BMPR2 0.601279551368824 0.00016685097085251 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.213406658258386 2.11523139256821e-11 NA NA NA hsa-miR-20a-5p BMPR2 0.854326758727003 5.04256669663285e-07 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.240712956475078 2.24570589605185e-16 NA NA NA hsa-miR-21-5p BMPR2 1.51084295924322 1.54551622173259e-34 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;miRTarBase;MirTarget -0.284574090091544 7.19521500454622e-14 NA NA NA hsa-miR-25-3p BMPR2 0.633062563556379 3.68686354834328e-10 -0.735692104466334 2.00485450351153e-12 miRNATAP -0.165757084106315 0.00116745992362732 NA NA NA hsa-miR-29a-5p BMPR2 -0.113555908626946 0.349622266470788 -0.735692104466334 2.00485450351153e-12 mirMAP -0.147830720470257 0.00063333183931133 NA NA NA hsa-miR-301a-3p BMPR2 0.842910511640361 1.43446467417891e-06 -0.735692104466334 2.00485450351153e-12 MirTarget;miRNATAP -0.109852401653794 0.000191922548679836 NA NA NA hsa-miR-30d-5p BMPR2 0.718283816348023 2.47422074061352e-08 -0.735692104466334 2.00485450351153e-12 mirMAP -0.192680093080354 1.22378821100091e-06 NA NA NA hsa-miR-362-3p BMPR2 0.814007335895913 2.00108618836568e-09 -0.735692104466334 2.00485450351153e-12 MirTarget;PITA;miRanda;miRNATAP -0.176480837537144 2.67432279837285e-06 NA NA NA hsa-miR-455-5p BMPR2 -0.270546034117157 0.0581320703577731 -0.735692104466334 2.00485450351153e-12 PITA -0.128605088499673 0.000444129926379739 NA NA NA hsa-miR-532-5p BMPR2 1.02729546510601 9.93318913966636e-16 -0.735692104466334 2.00485450351153e-12 PITA -0.287474341863181 7.79954625495596e-14 NA NA NA hsa-miR-590-5p BMPR2 -0.103355559980404 0.310027295317092 -0.735692104466334 2.00485450351153e-12 MirTarget;PITA;miRNATAP -0.192437141753484 0.000199081821262727 NA NA NA hsa-miR-618 BMPR2 0.13539895350352 0.517145913114103 -0.735692104466334 2.00485450351153e-12 PITA;mirMAP -0.104710045816621 4.93634023271714e-05 NA NA NA hsa-miR-671-5p BMPR2 0.843645373345787 3.92794196273313e-08 -0.735692104466334 2.00485450351153e-12 miRNATAP -0.105325283608643 0.00170736830794517 NA NA NA hsa-miR-769-5p BMPR2 0.219661452072771 0.0333425465750576 -0.735692104466334 2.00485450351153e-12 miRNATAP -0.151503783690954 0.00299663761326287 NA NA NA hsa-miR-877-5p BMPR2 1.35669625926821 1.43008125755656e-11 -0.735692104466334 2.00485450351153e-12 MirTarget -0.152834848664501 5.00642626283946e-09 NA NA NA hsa-miR-92a-3p BMPR2 0.212391012518195 0.134292268089997 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;miRNATAP -0.242426688195997 2.09632606862697e-11 NA NA NA hsa-miR-93-3p BMPR2 0.402821129107592 0.00131324842735588 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate -0.19142388334342 3.75720841597008e-06 NA NA NA hsa-miR-93-5p BMPR2 1.39518349670953 2.84167728726712e-25 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.270878794921134 3.0942354684122e-14 NA NA NA hsa-miR-107 CDKN2B 0.241662461253461 0.0170788899505389 1.37191742600332 3.8601745589837e-15 PITA -0.22214715039643 0.0113151536408877 NA NA NA hsa-miR-126-5p CDKN2B -0.428561469405594 6.6035585844222e-05 1.37191742600332 3.8601745589837e-15 mirMAP -0.331524443678709 4.86520309619025e-05 NA NA NA hsa-miR-144-3p CDKN2B -2.97536914478815 6.00546047309683e-28 1.37191742600332 3.8601745589837e-15 MirTarget -0.165363817374004 2.99908004062454e-08 NA NA NA hsa-miR-382-5p CDKN2B -0.71884748690977 0.00849172229801356 1.37191742600332 3.8601745589837e-15 mirMAP -0.101243601276092 0.00159366073719854 NA NA NA hsa-miR-450b-5p CDKN2B -1.34333360369432 2.68386079790462e-17 1.37191742600332 3.8601745589837e-15 mirMAP -0.177653728760579 0.000849213139863512 NA NA NA hsa-miR-451a CDKN2B -2.1025161666445 6.82555767537341e-17 1.37191742600332 3.8601745589837e-15 MirTarget -0.162386705840671 1.05027558906518e-06 NA NA NA hsa-miR-486-5p CDKN2B -1.77766890600022 2.9071717929922e-14 1.37191742600332 3.8601745589837e-15 miRanda -0.19221239071621 9.16912999787263e-08 NA NA NA hsa-let-7a-2-3p CHRD -1.19254913456912 1.47840144520517e-08 -0.0343248296218492 0.860981083059556 MirTarget -0.119055206574767 0.00805618935290589 NA NA NA hsa-let-7a-5p CHRD -0.328069937201898 0.000464344093744051 -0.0343248296218492 0.860981083059556 MirTarget;TargetScan;miRNATAP -0.307095000525603 0.0026964092650423 NA NA NA hsa-let-7b-5p CHRD -0.959013717270803 5.95127281258643e-11 -0.0343248296218492 0.860981083059556 MirTarget;miRNATAP -0.190639630022856 0.00276112583394826 NA NA NA hsa-let-7d-5p CHRD 0.0503292020123807 0.702580311853671 -0.0343248296218492 0.860981083059556 MirTarget;miRNATAP -0.273292046321681 0.000163958128976676 NA NA NA hsa-let-7e-5p CHRD 0.0350298755544731 0.811068614727804 -0.0343248296218492 0.860981083059556 MirTarget;miRNATAP -0.194022896291558 0.00298159683864948 NA NA NA hsa-let-7f-5p CHRD -0.230160552243429 0.103292420192651 -0.0343248296218492 0.860981083059556 MirTarget;miRNATAP -0.141560674615547 0.0370180072039005 NA NA NA hsa-let-7g-5p CHRD -0.461294133285527 2.17210114729901e-05 -0.0343248296218492 0.860981083059556 MirTarget;miRNATAP -0.183232554945298 0.0370753832699381 NA NA NA hsa-let-7i-5p CHRD -0.14267936165213 0.154141689875847 -0.0343248296218492 0.860981083059556 MirTarget;miRNATAP -0.366728363501923 0.00013111357543428 NA NA NA hsa-miR-98-5p CHRD -0.0487189107419432 0.715911066732548 -0.0343248296218492 0.860981083059556 MirTarget -0.273117614123379 0.000129524621135417 NA NA NA hsa-miR-324-3p CREBBP 0.260348469146494 0.0506141704203545 -0.198953226514463 0.0138678371438249 miRNAWalker2_validate -0.122219674872295 3.31240083157391e-05 NA NA NA hsa-miR-330-5p CREBBP 0.442231058604099 0.0053308560843808 -0.198953226514463 0.0138678371438249 miRanda -0.10760918491025 1.18364633640293e-05 NA NA NA hsa-miR-769-5p CREBBP 0.219661452072771 0.0333425465750576 -0.198953226514463 0.0138678371438249 miRNAWalker2_validate -0.128844707446474 0.00077006671697313 NA NA NA hsa-miR-27a-3p CUL1 -0.370807380415112 0.00875721956202713 -0.117901782494851 0.10228448838388 miRNAWalker2_validate -0.100449098638373 4.43211535246804e-05 NA NA NA hsa-miR-146b-5p DCN 0.419719546795449 0.0457375823220155 -4.16086251487049 1.15620570061837e-21 miRanda -0.226596464669267 0.0333660092962088 NA NA NA hsa-miR-186-5p DCN -0.060103391373687 0.535288717081205 -4.16086251487049 1.15620570061837e-21 mirMAP -0.854956418637479 0.00023962626758074 NA NA NA hsa-miR-374b-3p DCN -0.137420230218985 0.305318192448799 -4.16086251487049 1.15620570061837e-21 MirTarget -0.443951014167465 0.00820846134725373 NA NA NA hsa-miR-421 DCN 0.941856334694081 6.12167297054077e-08 -4.16086251487049 1.15620570061837e-21 miRanda -0.713744467424654 1.22619058359562e-08 NA NA NA hsa-miR-501-5p DCN 1.15231083477882 2.98906150004088e-10 -4.16086251487049 1.15620570061837e-21 mirMAP -0.295437669096331 0.0137542947673295 NA NA NA hsa-miR-23b-3p E2F4 -0.530561587109023 5.43807206823652e-07 0.52624092062884 1.99370091261106e-11 miRNAWalker2_validate -0.134293182725783 0.000238709419026524 NA NA NA hsa-let-7a-2-3p E2F5 -1.19254913456912 1.47840144520517e-08 0.730554652437087 0.000401890915871585 MirTarget -0.236368683960896 5.41845122818239e-07 NA NA NA hsa-let-7a-5p E2F5 -0.328069937201898 0.000464344093744051 0.730554652437087 0.000401890915871585 MirTarget;TargetScan;miRNATAP -0.388478797116257 0.00033740750885559 NA NA NA hsa-let-7b-5p E2F5 -0.959013717270803 5.95127281258643e-11 0.730554652437087 0.000401890915871585 miRNAWalker2_validate;MirTarget;miRNATAP -0.21870636746378 0.00120101767570817 NA NA NA hsa-let-7c-5p E2F5 -1.70744661345097 2.87934212005942e-20 0.730554652437087 0.000401890915871585 MirTarget -0.228095461415917 1.04748751614991e-05 NA NA NA hsa-let-7g-3p E2F5 -1.14091000722297 8.32736018188759e-19 0.730554652437087 0.000401890915871585 MirTarget;miRNATAP -0.30841341167427 3.97782527999337e-05 NA NA NA hsa-let-7g-5p E2F5 -0.461294133285527 2.17210114729901e-05 0.730554652437087 0.000401890915871585 MirTarget;miRNATAP -0.281429469337869 0.0024764517018281 NA NA NA hsa-miR-1-3p E2F5 -0.658358049898834 0.0102519519479171 0.730554652437087 0.000401890915871585 MirTarget -0.10626442102449 0.00712838434232038 NA NA NA hsa-miR-192-5p E2F5 -0.50188499512787 0.00344713341196035 0.730554652437087 0.000401890915871585 miRNAWalker2_validate -0.165569976807069 0.00489423335560786 NA NA NA hsa-miR-3653-3p E2F5 -1.77536656608462 3.05384496241509e-24 0.730554652437087 0.000401890915871585 MirTarget -0.158966973078016 0.00370031639799338 NA NA NA hsa-miR-378a-3p E2F5 -1.1920055906972 3.23538871733634e-10 0.730554652437087 0.000401890915871585 miRNAWalker2_validate -0.193048272442212 0.000208784950864508 NA NA NA hsa-miR-491-5p E2F5 -0.369122930844418 0.0154047757048929 0.730554652437087 0.000401890915871585 miRanda -0.13640094312517 0.04254097661712 NA NA NA hsa-miR-22-3p EP300 -0.628561621952407 1.33755558015523e-09 -0.200382966790078 0.0704945874784134 MirTarget;miRNATAP -0.102672783880902 0.0463193353503437 NA NA NA hsa-miR-30d-3p EP300 -0.120562286038759 0.329549534782125 -0.200382966790078 0.0704945874784134 MirTarget;miRNATAP -0.106915117943506 0.0149374124449437 NA NA NA hsa-miR-339-5p EP300 0.280589919878422 0.0355660282647215 -0.200382966790078 0.0704945874784134 miRanda -0.157358640254018 9.53193539159902e-05 NA NA NA hsa-miR-342-3p EP300 -0.319677314984262 0.0449813878317147 -0.200382966790078 0.0704945874784134 MirTarget;PITA;miRanda;miRNATAP -0.112632997815777 0.000853079257159957 NA NA NA hsa-miR-361-3p EP300 0.275658012727111 0.00549374744374488 -0.200382966790078 0.0704945874784134 PITA -0.113790418081702 0.0379052782907214 NA NA NA hsa-miR-320a FST 0.325285936317332 0.0221415065838824 -0.599816610307366 0.0557921820952576 PITA;miRanda -0.361201156525979 0.000787818166902219 NA NA NA hsa-miR-320b FST 0.0919652022571331 0.607981643616945 -0.599816610307366 0.0557921820952576 PITA;miRanda -0.255722665535006 0.00292862924571907 NA NA NA hsa-miR-425-5p FST 0.585974239943864 2.23063410931402e-05 -0.599816610307366 0.0557921820952576 MirTarget -0.222097651196196 0.0442045100313864 NA NA NA hsa-miR-769-5p FST 0.219661452072771 0.0333425465750576 -0.599816610307366 0.0557921820952576 MirTarget;miRNATAP -0.493592902359727 0.000938941481926615 NA NA NA hsa-miR-148a-3p GDF6 -0.748702855596996 3.93313343865641e-07 -2.10139054692363 1.01669881798518e-11 miRNATAP -0.327974606729441 0.00151705432220982 NA NA NA hsa-miR-324-5p GDF6 0.372933276649782 0.00592280066108904 -2.10139054692363 1.01669881798518e-11 miRanda -0.3280163006671 0.00405331751922112 NA NA NA hsa-miR-532-3p GDF6 0.297601533259956 0.014632205884815 -2.10139054692363 1.01669881798518e-11 PITA;miRNATAP -0.562088337736992 8.64759385655773e-06 NA NA NA hsa-miR-589-3p GDF6 1.16846704028095 5.88525574424201e-11 -2.10139054692363 1.01669881798518e-11 MirTarget -0.263843974926024 0.00226413038643534 NA NA NA hsa-miR-616-5p GDF6 0.150569904638223 0.402836556304524 -2.10139054692363 1.01669881798518e-11 mirMAP -0.217633894052347 0.0117114781099797 NA NA NA hsa-miR-197-3p GDF7 -0.245033899783728 0.0362223947695203 -1.70565631034897 1.45352939577227e-07 miRNAWalker2_validate -0.652312246172849 1.84706393928919e-06 NA NA NA hsa-miR-224-3p GDF7 1.40770116795301 1.31426607144612e-08 -1.70565631034897 1.45352939577227e-07 mirMAP -0.33032138163421 2.19235580868161e-07 NA NA NA hsa-miR-502-5p GDF7 0.892373335336396 1.7122694518919e-06 -1.70565631034897 1.45352939577227e-07 mirMAP -0.285883912037438 0.000979251400949544 NA NA NA hsa-miR-16-2-3p ID1 -0.0336420826463706 0.805158952566973 -2.25178919025733 7.10820515452733e-23 MirTarget -0.189998353916994 0.0290097044760579 NA NA NA hsa-miR-192-5p ID1 -0.50188499512787 0.00344713341196035 -2.25178919025733 7.10820515452733e-23 miRNAWalker2_validate -0.14911812571484 0.0297833314669114 NA NA NA hsa-miR-103a-3p ID2 0.765568928457606 3.05497476509383e-12 -1.61066414419896 4.81945990305561e-27 miRNAWalker2_validate;miRTarBase -0.312121729027969 6.10447032095761e-06 NA NA NA hsa-miR-362-3p ID2 0.814007335895913 2.00108618836568e-09 -1.61066414419896 4.81945990305561e-27 miRanda;mirMAP -0.135739450698705 0.0163044877473145 NA NA NA hsa-miR-3127-5p ID3 0.837385386388614 2.06679743975142e-07 -0.641422444526658 3.13276715121983e-05 MirTarget -0.148729515445601 0.00133066065654212 NA NA NA hsa-miR-148a-5p ID4 -0.767626696027761 1.08359477494797e-06 -1.27298671386794 2.11782253912459e-06 MirTarget -0.580939422209125 8.00990887130119e-13 NA NA NA hsa-miR-186-5p ID4 -0.060103391373687 0.535288717081205 -1.27298671386794 2.11782253912459e-06 miRNAWalker2_validate;mirMAP -0.329735875841619 0.0173063251631018 NA NA NA hsa-miR-192-5p ID4 -0.50188499512787 0.00344713341196035 -1.27298671386794 2.11782253912459e-06 miRNAWalker2_validate -0.512916510271531 9.38394493873178e-12 NA NA NA hsa-miR-324-3p ID4 0.260348469146494 0.0506141704203545 -1.27298671386794 2.11782253912459e-06 miRNAWalker2_validate;PITA -0.36557492342123 0.000237292613574257 NA NA NA hsa-miR-340-5p ID4 -0.00477614531381576 0.968502722773791 -1.27298671386794 2.11782253912459e-06 miRNAWalker2_validate -0.217769770207405 0.0489325757353652 NA NA NA hsa-miR-345-5p ID4 -0.712725883885838 3.60393522979373e-06 -1.27298671386794 2.11782253912459e-06 MirTarget -0.227915686328079 0.00758841843765282 NA NA NA hsa-miR-362-3p ID4 0.814007335895913 2.00108618836568e-09 -1.27298671386794 2.11782253912459e-06 miRanda -0.290749084974638 0.00244868856264653 NA NA NA hsa-miR-421 ID4 0.941856334694081 6.12167297054077e-08 -1.27298671386794 2.11782253912459e-06 miRanda -0.266368436340602 0.000390882956835244 NA NA NA hsa-miR-532-3p ID4 0.297601533259956 0.014632205884815 -1.27298671386794 2.11782253912459e-06 PITA -0.565900232539255 1.52066740650302e-07 NA NA NA hsa-miR-589-3p ID4 1.16846704028095 5.88525574424201e-11 -1.27298671386794 2.11782253912459e-06 MirTarget -0.28041293463254 0.000145959542683529 NA NA NA hsa-miR-590-5p ID4 -0.103355559980404 0.310027295317092 -1.27298671386794 2.11782253912459e-06 miRanda -0.503024834896881 0.000122635297440852 NA NA NA hsa-miR-148b-3p INHBA 0.266862251671911 0.00185271302045935 -1.24139262923259 1.82491752448182e-06 miRNAWalker2_validate -0.4775304543089 0.00158928464481298 NA NA NA hsa-miR-30d-5p INHBA 0.718283816348023 2.47422074061352e-08 -1.24139262923259 1.82491752448182e-06 mirMAP -0.475857712731218 1.05402445581133e-06 NA NA NA hsa-miR-421 INHBA 0.941856334694081 6.12167297054077e-08 -1.24139262923259 1.82491752448182e-06 miRanda -0.157684079206626 0.03110104335894 NA NA NA hsa-miR-34a-5p INHBB 1.03694231790865 5.74864019540594e-14 -0.716094510918822 0.000267948992937716 miRNATAP -0.284301776707405 2.5200278912638e-05 NA NA NA hsa-miR-125a-3p INHBC -0.841683158494395 3.51202687176603e-05 -2.18262133889266 1.7288848789461e-11 MirTarget;miRanda -0.377937201588012 2.46593746966734e-06 NA NA NA hsa-miR-224-3p LTBP1 1.40770116795301 1.31426607144612e-08 -1.32612816740388 3.79930867511623e-09 MirTarget -0.107927802475616 0.0163560348383435 NA NA NA hsa-miR-92a-3p LTBP1 0.212391012518195 0.134292268089997 -1.32612816740388 3.79930867511623e-09 miRNAWalker2_validate -0.314544154611284 6.46092803781827e-05 NA NA NA hsa-miR-20a-5p MYC 0.854326758727003 5.04256669663285e-07 -1.53204423111148 3.53987625613016e-10 miRNAWalker2_validate -0.165031814042356 0.0197576054298013 26012475 Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex colon cancer hsa-miR-423-5p MYC 0.698807775906485 1.02195196334612e-11 -1.53204423111148 3.53987625613016e-10 miRNAWalker2_validate -0.328206409340035 0.00484551582134482 NA NA NA hsa-miR-139-5p PITX2 -2.11299531796557 8.16407076415038e-28 0.732706410516242 0.0439037980226132 miRanda -0.489473425936468 6.88600285962409e-09 NA NA NA hsa-miR-28-5p PITX2 -0.430964830599964 2.67367257252925e-06 0.732706410516242 0.0439037980226132 miRanda -0.625265232258957 0.00121464664225927 NA NA NA hsa-miR-30a-3p PITX2 -1.52720594401486 1.3830066075708e-17 0.732706410516242 0.0439037980226132 miRNATAP -0.361949119735132 0.000136278838596342 NA NA NA hsa-miR-30d-3p PITX2 -0.120562286038759 0.329549534782125 0.732706410516242 0.0439037980226132 miRNATAP -0.412311008382536 0.00431355325421292 NA NA NA hsa-miR-421 PPP2CB 0.941856334694081 6.12167297054077e-08 -0.890331286940364 2.58768297455211e-18 miRNAWalker2_validate;miRanda -0.107091673318932 0.000264470518633695 NA NA NA hsa-miR-425-5p PPP2CB 0.585974239943864 2.23063410931402e-05 -0.890331286940364 2.58768297455211e-18 miRNAWalker2_validate -0.210079108287547 1.06195847865028e-08 NA NA NA hsa-miR-940 PPP2CB 0.453020092551484 0.0177054921651997 -0.890331286940364 2.58768297455211e-18 MirTarget;PITA -0.108413768942713 9.39010367602326e-05 NA NA NA hsa-miR-16-5p PPP2R1A -0.398577235179603 0.000101598495180191 0.434617655824211 2.19736728815959e-07 miRNAWalker2_validate -0.16156782548915 5.72423585631049e-05 NA NA NA hsa-miR-505-5p PPP2R1A -0.768282569967001 1.14662846595407e-05 0.434617655824211 2.19736728815959e-07 miRNAWalker2_validate -0.101132276982143 1.32519884220096e-05 NA NA NA hsa-miR-15a-5p PPP2R1B 0.349521211668244 0.000770735998804736 -0.366373279268895 0.0120240053013953 MirTarget -0.149129894906409 0.0304654709530036 NA NA NA hsa-miR-15b-5p PPP2R1B 0.230566941413564 0.0824765001857479 -0.366373279268895 0.0120240053013953 MirTarget -0.166547119923006 0.0019576167364681 NA NA NA hsa-miR-30b-5p PPP2R1B -0.54056186708617 2.44688760798341e-05 -0.366373279268895 0.0120240053013953 miRNATAP -0.174282215186143 0.00161533222972509 NA NA NA hsa-miR-30d-3p PPP2R1B -0.120562286038759 0.329549534782125 -0.366373279268895 0.0120240053013953 mirMAP -0.172420555072298 0.00291249897697552 NA NA NA hsa-miR-30d-5p PPP2R1B 0.718283816348023 2.47422074061352e-08 -0.366373279268895 0.0120240053013953 miRNATAP -0.122684938544671 0.0248523471709719 NA NA NA hsa-miR-330-3p PPP2R1B -0.332364259424489 0.0316051913061459 -0.366373279268895 0.0120240053013953 mirMAP -0.117464840218715 0.0128019984692913 NA NA NA hsa-miR-423-3p PPP2R1B 0.302157659154355 0.000669907339064765 -0.366373279268895 0.0120240053013953 miRNAWalker2_validate -0.175790608241052 0.0299905282650269 NA NA NA hsa-miR-744-3p PPP2R1B -0.866026958622846 2.43034431433797e-08 -0.366373279268895 0.0120240053013953 MirTarget -0.151341218126979 0.000790301774844116 NA NA NA hsa-miR-122-5p RBL1 -1.23907441373955 4.42181244888642e-06 1.01562013245512 3.92765086455926e-07 MirTarget -0.233942086696873 4.05290204360084e-11 NA NA NA hsa-miR-106a-5p RBL2 -0.464229535269236 0.009724944358047 -0.988381422306337 9.82564074336519e-12 MirTarget;miRNATAP -0.117107890118936 0.00367936194107588 24045973 Among many miR-106a predicated target genes p130 RBL2 an retinoblastoma Rb tumor suppressor family member was not only confirmed as a specific target of miR-106a but also related to tumor growth and differentiation; The importance of mir-106a and RBL2 was further demonstrated in vivo in which SKOV3 cells overexpressing miR-106a formed poorly differentiated carcinomas and had reduced RBL2 levels differentiation ovarian cancer hsa-miR-106b-5p RBL2 0.648901865047099 8.24870862047885e-09 -0.988381422306337 9.82564074336519e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.467612098017658 4.18657885507219e-14 NA NA NA hsa-miR-107 RBL2 0.241662461253461 0.0170788899505389 -0.988381422306337 9.82564074336519e-12 miRanda -0.167329440185504 0.0206264972294066 NA NA NA hsa-miR-17-5p RBL2 0.698861147045461 2.43854106455398e-05 -0.988381422306337 9.82564074336519e-12 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.343656172428148 2.71737625593314e-16 NA NA NA hsa-miR-20a-5p RBL2 0.854326758727003 5.04256669663285e-07 -0.988381422306337 9.82564074336519e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.264295882999639 1.60446558088321e-10 NA NA NA hsa-miR-335-3p RBL2 -0.275199247483111 0.106629165248783 -0.988381422306337 9.82564074336519e-12 MirTarget -0.114041268766779 0.00743241946989908 NA NA NA hsa-miR-421 RBL2 0.941856334694081 6.12167297054077e-08 -0.988381422306337 9.82564074336519e-12 miRanda -0.251090760557798 5.73687778774342e-10 NA NA NA hsa-miR-93-5p RBL2 1.39518349670953 2.84167728726712e-25 -0.988381422306337 9.82564074336519e-12 MirTarget;miRNATAP -0.408615196615982 9.43227929469049e-17 NA NA NA hsa-miR-139-5p RBX1 -2.11299531796557 8.16407076415038e-28 0.27440095690029 0.00162986680164289 miRanda -0.10537307725778 2.07264839791855e-07 NA NA NA hsa-miR-324-5p ROCK1 0.372933276649782 0.00592280066108904 -0.264366618624451 0.00575875249305368 MirTarget;PITA;miRanda -0.132464043588386 0.000113488217308036 NA NA NA hsa-miR-17-5p ROCK2 0.698861147045461 2.43854106455398e-05 -0.343723141838983 0.0978147147700846 TargetScan -0.230848684676223 0.000132737616833034 NA NA NA hsa-miR-126-5p RPS6KB1 -0.428561469405594 6.6035585844222e-05 0.0405513114293425 0.579068505304799 mirMAP -0.106946073918378 0.00114467289374143 NA NA NA hsa-miR-145-5p RPS6KB1 -1.4795885711477 6.47308361543414e-16 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.109724019103871 2.07298188703538e-09 24157791 MiR 145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1; MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3'UTRs; Importantly the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145 respectively; Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1 functioning as a tumor suppressor ovarian cancer hsa-miR-181a-5p RPS6KB1 0.250113435902954 0.0551933249319293 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.116671963226395 1.5972465565874e-05 NA NA NA hsa-miR-181c-5p RPS6KB1 -0.00639394152050299 0.969127212255928 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.10835890138279 3.360156885851e-07 NA NA NA hsa-miR-27a-3p RPS6KB1 -0.370807380415112 0.00875721956202713 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.13716383977936 2.72226167197111e-08 NA NA NA hsa-miR-342-3p RPS6KB1 -0.319677314984262 0.0449813878317147 0.0405513114293425 0.579068505304799 miRanda -0.115090266357129 1.55784431831661e-07 NA NA NA hsa-miR-542-3p RPS6KB1 -1.31351015149842 3.64642423288576e-22 0.0405513114293425 0.579068505304799 miRNATAP -0.102388373747613 3.28524227017976e-05 NA NA NA hsa-miR-125a-5p RPS6KB2 -0.91219969372382 1.38256246489548e-07 0.230775242252044 0.00570601482278892 miRanda -0.115997614156545 4.04919339586598e-07 NA NA NA hsa-miR-450b-5p SKP1 -1.34333360369432 2.68386079790462e-17 0.220350434523828 0.00211239594525225 miRNATAP -0.104764813664882 5.36557139667176e-07 NA NA NA hsa-miR-7-1-3p SKP1 -0.569105143287799 1.85297665041424e-05 0.220350434523828 0.00211239594525225 MirTarget;mirMAP -0.109724018574561 2.33101260912259e-05 NA NA NA hsa-miR-17-5p SMAD1 0.698861147045461 2.43854106455398e-05 -0.766119082328572 3.17324503519034e-10 TargetScan -0.271438450894389 1.28614752715314e-14 NA NA NA hsa-miR-30d-5p SMAD1 0.718283816348023 2.47422074061352e-08 -0.766119082328572 3.17324503519034e-10 miRNAWalker2_validate;miRTarBase -0.164510281478173 0.000382736580996914 NA NA NA hsa-miR-421 SMAD1 0.941856334694081 6.12167297054077e-08 -0.766119082328572 3.17324503519034e-10 PITA;miRanda -0.204012492922758 1.7229707263226e-09 NA NA NA hsa-miR-589-3p SMAD1 1.16846704028095 5.88525574424201e-11 -0.766119082328572 3.17324503519034e-10 MirTarget -0.222094662072 2.14494232480849e-11 NA NA NA hsa-miR-590-5p SMAD1 -0.103355559980404 0.310027295317092 -0.766119082328572 3.17324503519034e-10 miRanda -0.273958507619009 4.4256713892777e-06 NA NA NA hsa-miR-455-5p SMAD2 -0.270546034117157 0.0581320703577731 0.315604980822302 9.76507196938151e-07 miRanda -0.126014730396316 7.82261975485323e-09 NA NA NA hsa-let-7g-3p SMAD3 -1.14091000722297 8.32736018188759e-19 0.313849246286883 0.00280528337161062 mirMAP -0.100129949934208 0.00883180340844614 NA NA NA hsa-miR-142-5p SMAD3 -1.44575553250033 1.18797044680592e-13 0.313849246286883 0.00280528337161062 PITA -0.125868007472141 6.14850270977044e-07 NA NA NA hsa-miR-155-5p SMAD3 0.0108524225071784 0.95651331033505 0.313849246286883 0.00280528337161062 miRNAWalker2_validate -0.143616291871971 1.61818308217997e-08 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-1976 SMAD3 -0.431472440543166 0.00324575010550946 0.313849246286883 0.00280528337161062 MirTarget -0.177460759581402 2.8140086065009e-07 NA NA NA hsa-miR-29b-2-5p SMAD3 -0.223258653034772 0.084306146519938 0.313849246286883 0.00280528337161062 mirMAP -0.124265788567886 0.00177731205069881 NA NA NA hsa-miR-30e-3p SMAD3 -1.20845647373031 3.10263633528203e-25 0.313849246286883 0.00280528337161062 mirMAP -0.103475289171098 0.0130534195616259 NA NA NA hsa-miR-326 SMAD3 -1.881935132554 1.68087316863775e-21 0.313849246286883 0.00280528337161062 miRanda -0.121886887629074 7.48502793476032e-07 NA NA NA hsa-miR-424-5p SMAD3 -2.62653257498508 2.38997974737991e-50 0.313849246286883 0.00280528337161062 MirTarget -0.105846554796035 3.45471115916176e-05 27655675 miR 424 5p promotes proliferation of gastric cancer by targeting Smad3 through TGF β signaling pathway; QRT-PCR was used to determine the expression levels of miR-424-5p and Smad3; Luciferase reporter assay and western blotting were used to prove that Smad3 was one of the direct targets of miR-424-5p; In addition luciferase reporter assay and western blotting assay revealed that Smad3 was a direct target of miR-424-5p; Over-expression of Smad3 could partially reverse the effects of miR-424-5p on GC cell proliferation; Our study further revealed that miR-424-5p could inhibit TGF-β signaling pathway by Smad3 gastric cancer hsa-miR-29b-2-5p SMAD4 -0.223258653034772 0.084306146519938 -0.30976054630181 7.55983294717014e-05 MirTarget -0.1066651080199 0.000315915680961711 NA NA NA hsa-miR-34a-5p SMAD4 1.03694231790865 5.74864019540594e-14 -0.30976054630181 7.55983294717014e-05 miRNATAP -0.106481148933391 7.14459232465546e-05 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-500a-5p SMAD4 0.797906382969156 9.15958171084226e-08 -0.30976054630181 7.55983294717014e-05 mirMAP -0.104579732494838 3.18281872137464e-05 NA NA NA hsa-miR-148a-3p SMAD5 -0.748702855596996 3.93313343865641e-07 0.163025158576987 0.0964365530955469 MirTarget -0.118682964369505 0.000191401765007103 NA NA NA hsa-miR-186-5p SMAD5 -0.060103391373687 0.535288717081205 0.163025158576987 0.0964365530955469 miRNAWalker2_validate;MirTarget -0.103316038272731 0.0383682766202006 NA NA NA hsa-miR-107 SMAD6 0.241662461253461 0.0170788899505389 -1.36817044323967 1.17156586139272e-15 miRanda -0.248513219098474 0.00380041537676058 NA NA NA hsa-miR-17-5p SMAD6 0.698861147045461 2.43854106455398e-05 -1.36817044323967 1.17156586139272e-15 TargetScan -0.345938083046653 7.76189995704034e-12 NA NA NA hsa-miR-330-5p SMAD6 0.442231058604099 0.0053308560843808 -1.36817044323967 1.17156586139272e-15 miRanda -0.214270579435197 7.41498684568719e-05 NA NA NA hsa-miR-362-3p SMAD6 0.814007335895913 2.00108618836568e-09 -1.36817044323967 1.17156586139272e-15 miRanda -0.307073339905866 7.24912407874465e-07 NA NA NA hsa-miR-17-5p SMAD7 0.698861147045461 2.43854106455398e-05 -0.723856409040082 1.50332971335389e-07 TargetScan;miRNATAP -0.111337794005623 0.00639287149320827 NA NA NA hsa-miR-20a-5p SMAD7 0.854326758727003 5.04256669663285e-07 -0.723856409040082 1.50332971335389e-07 miRNATAP -0.116628969266854 0.00318831344924215 NA NA NA hsa-miR-21-3p SMAD7 -0.484219378716006 0.00299941098417659 -0.723856409040082 1.50332971335389e-07 MirTarget -0.101250788505418 0.0151930427299818 23372687;27185036;26531758 Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MicroRNA 21 Regulates Non Small Cell Lung Cancer Cell Invasion and Chemo Sensitivity through SMAD7; We performed bioinformatics analyses on the binding of microRNA-21 miR-21 to the 3'-UTR of SMAD7 mRNA and verified the biological effects of this binding using promoter luciferase reporter assay; Furthermore expression of miR-21 was found to be inhibited by Carboplatin and bioinformatics analyses showed that miR-21 targeted the 3'-UTR of SMAD7 mRNA to inhibit its translation which was confirmed by luciferase reporter assay; Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFβ receptor signaling mediated NSCLC cell invasion;MicroRNA 21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF β pathways; The present study was undertaken to determine the association of miR-21 smad7 EGF and TGF-β with breast cancer cell invasion and migration and to identify the molecular mechanisms involved using immunohistochemistry and western blot analysis; Smad7 was confirmed to be a direct target of miR-21 by luciferase reporter and western blot assays; The downregulation of smad7 by miR-21 or sismad7 enhanced EGF-dependent invasion and migration as well as TGF-β-dependent invasion and migration; The actions of miR-21 were abrogated by expressing a modified smad7 cDNA resistant to miR-21; In conclusion our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7 which enhances EGF and TGF-β pathways ;; breast cancer;lung squamous cell cancer;breast cancer hsa-miR-21-5p SMAD7 1.51084295924322 1.54551622173259e-34 -0.723856409040082 1.50332971335389e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.273576086802476 5.38840691437798e-08 23372687;27185036;26531758 Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MicroRNA 21 Regulates Non Small Cell Lung Cancer Cell Invasion and Chemo Sensitivity through SMAD7; We performed bioinformatics analyses on the binding of microRNA-21 miR-21 to the 3'-UTR of SMAD7 mRNA and verified the biological effects of this binding using promoter luciferase reporter assay; Furthermore expression of miR-21 was found to be inhibited by Carboplatin and bioinformatics analyses showed that miR-21 targeted the 3'-UTR of SMAD7 mRNA to inhibit its translation which was confirmed by luciferase reporter assay; Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFβ receptor signaling mediated NSCLC cell invasion;MicroRNA 21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF β pathways; The present study was undertaken to determine the association of miR-21 smad7 EGF and TGF-β with breast cancer cell invasion and migration and to identify the molecular mechanisms involved using immunohistochemistry and western blot analysis; Smad7 was confirmed to be a direct target of miR-21 by luciferase reporter and western blot assays; The downregulation of smad7 by miR-21 or sismad7 enhanced EGF-dependent invasion and migration as well as TGF-β-dependent invasion and migration; The actions of miR-21 were abrogated by expressing a modified smad7 cDNA resistant to miR-21; In conclusion our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7 which enhances EGF and TGF-β pathways ;; breast cancer;lung squamous cell cancer;breast cancer hsa-miR-34a-5p SMAD7 1.03694231790865 5.74864019540594e-14 -0.723856409040082 1.50332971335389e-07 MirTarget -0.188822980243553 7.67367411949942e-05 NA NA NA hsa-miR-92a-3p SMAD7 0.212391012518195 0.134292268089997 -0.723856409040082 1.50332971335389e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.15091812247193 0.0017147833023436 NA NA NA hsa-miR-93-5p SMAD7 1.39518349670953 2.84167728726712e-25 -0.723856409040082 1.50332971335389e-07 miRNATAP -0.139906211007762 0.00344672878271456 25371073 Mothers against decapentaplegic homolog 7 Smad7 as an essential molecular protein for nuclear accumulation of β-catenin in the canonical Wnt signaling pathway is predicted as a putative target gene of miR-93 by the silico method and demonstrated that it may be suppressed by targeting its 3'UTR; These findings showed that miR-93 suppresses colorectal cancer development via downregulating Wnt/β-catenin at least in part by targeting Smad7 colorectal cancer hsa-miR-103a-2-5p SMAD9 1.17085533927423 5.31418969120877e-09 -1.49767600167527 1.61311444052049e-07 mirMAP -0.193961235539457 0.00776996724592502 NA NA NA hsa-miR-106b-5p SMAD9 0.648901865047099 8.24870862047885e-09 -1.49767600167527 1.61311444052049e-07 miRNAWalker2_validate;mirMAP -0.408893021846715 0.000978974278661984 NA NA NA hsa-miR-17-5p SMAD9 0.698861147045461 2.43854106455398e-05 -1.49767600167527 1.61311444052049e-07 mirMAP -0.303318490798727 0.000332751821165466 NA NA NA hsa-miR-20a-5p SMAD9 0.854326758727003 5.04256669663285e-07 -1.49767600167527 1.61311444052049e-07 mirMAP -0.324007275940665 7.46808100744451e-05 NA NA NA hsa-miR-29a-5p SMAD9 -0.113555908626946 0.349622266470788 -1.49767600167527 1.61311444052049e-07 MirTarget -0.249654784732606 0.0336975451043365 NA NA NA hsa-miR-374a-5p SMAD9 0.016390363747302 0.869784217438621 -1.49767600167527 1.61311444052049e-07 mirMAP -0.467016302415081 0.00108642697161675 NA NA NA hsa-miR-452-3p SMAD9 1.76909792952222 2.98172274671408e-10 -1.49767600167527 1.61311444052049e-07 MirTarget -0.175013309509885 0.000366323177594354 NA NA NA hsa-miR-455-5p SMAD9 -0.270546034117157 0.0581320703577731 -1.49767600167527 1.61311444052049e-07 MirTarget -0.205763141909193 0.0387283552319808 NA NA NA hsa-miR-616-5p SMAD9 0.150569904638223 0.402836556304524 -1.49767600167527 1.61311444052049e-07 mirMAP -0.289785146782817 0.00023073360735356 NA NA NA hsa-miR-93-5p SMAD9 1.39518349670953 2.84167728726712e-25 -1.49767600167527 1.61311444052049e-07 mirMAP -0.584387516246112 2.26188462521733e-09 NA NA NA hsa-miR-140-5p SMURF1 -0.220106443070144 0.0140713197101242 0.41243843797877 9.91971647783317e-06 PITA;miRanda -0.213183797663877 3.36718645082618e-05 NA NA NA hsa-miR-142-5p SMURF1 -1.44575553250033 1.18797044680592e-13 0.41243843797877 9.91971647783317e-06 MirTarget;PITA -0.111210714641553 8.2608016931334e-07 NA NA NA hsa-miR-15a-5p SMURF1 0.349521211668244 0.000770735998804736 0.41243843797877 9.91971647783317e-06 MirTarget;miRNATAP -0.126773466642466 0.00415872019676827 NA NA NA hsa-miR-16-5p SMURF1 -0.398577235179603 0.000101598495180191 0.41243843797877 9.91971647783317e-06 MirTarget;miRNATAP -0.140047623553933 0.00173036288784901 NA NA NA hsa-miR-197-3p SMURF1 -0.245033899783728 0.0362223947695203 0.41243843797877 9.91971647783317e-06 MirTarget -0.135552994560673 0.000556163072139177 NA NA NA hsa-miR-29b-2-5p SMURF1 -0.223258653034772 0.084306146519938 0.41243843797877 9.91971647783317e-06 mirMAP -0.105909373381818 0.00288955840730717 NA NA NA hsa-miR-107 SMURF2 0.241662461253461 0.0170788899505389 0.344618067830604 0.00268296348226083 miRanda -0.118392577637569 0.0341444295555421 NA NA NA hsa-miR-122-3p SMURF2 -1.75369011054591 1.52070648599898e-11 0.344618067830604 0.00268296348226083 MirTarget -0.140629048371772 7.54837110364061e-12 NA NA NA hsa-miR-122-5p SMURF2 -1.23907441373955 4.42181244888642e-06 0.344618067830604 0.00268296348226083 miRNAWalker2_validate -0.163762435787309 1.26775231361836e-16 NA NA NA hsa-miR-22-3p SP1 -0.628561621952407 1.33755558015523e-09 0.0334930719412458 0.566652742155962 miRNAWalker2_validate -0.168203459931884 1.70521621996518e-10 23529765;24906624 miR 22 is down regulated in gastric cancer and its overexpression inhibits cell migration and invasion via targeting transcription factor Sp1; Moreover we also showed that Sp1 was negatively regulated by miR-22 at the posttranscriptional level via a specific target site within the 3'UTR by luciferase reporter assay; The expression of Sp1 was inversely correlated with miR-22 expression in gastric cancer tissues and knockdown of Sp1 by siRNA inhibited cell malignant behaviors; Thus our findings suggest that miR-22 acts as tumor suppressor by targeting the Sp1 gene and inhibiting gastric cancer cell migration and invasion;We also determined that miR-22 could indirectly participate in CD147 modulation by downregulating Sp1 expression cell migration;malignant trasformation; gastric cancer;breast cancer hsa-miR-29b-3p SP1 -0.348885528720517 0.0121441341291285 0.0334930719412458 0.566652742155962 miRNAWalker2_validate;miRTarBase -0.119357938556111 2.14354032381039e-09 NA NA NA hsa-miR-365a-3p TFDP1 0.164591326307714 0.15325084963213 -0.0999016917841598 0.418682533968683 MirTarget -0.126792543524919 0.0158153705173069 NA NA NA hsa-miR-374b-5p TFDP1 -0.307538028546424 0.0030079617545972 -0.0999016917841598 0.418682533968683 MirTarget -0.123363572259343 0.034566737116552 NA NA NA hsa-miR-139-5p TGFB1 -2.11299531796557 8.16407076415038e-28 0.0791820105139553 0.6886056388594 miRanda -0.165335310650966 0.000359864512900183 NA NA NA hsa-miR-101-5p TGFB2 -1.0634649894055 4.39116719827902e-16 0.529934214584709 0.036730862150581 mirMAP -0.351880994764185 0.000113322446416492 NA NA NA hsa-miR-107 TGFB2 0.241662461253461 0.0170788899505389 0.529934214584709 0.036730862150581 miRanda -0.614314042069378 4.68765266846655e-07 NA NA NA hsa-miR-148a-3p TGFB2 -0.748702855596996 3.93313343865641e-07 0.529934214584709 0.036730862150581 MirTarget;miRNATAP -0.661431979951743 1.43220896593668e-16 NA NA NA hsa-miR-148b-3p TGFB2 0.266862251671911 0.00185271302045935 0.529934214584709 0.036730862150581 MirTarget -0.308316040007802 0.0351464261546803 NA NA NA hsa-miR-193a-3p TGFB2 -0.117675551589896 0.309391958208578 0.529934214584709 0.036730862150581 MirTarget;miRanda;miRNATAP -0.366329573810208 0.000659116520736421 NA NA NA hsa-miR-193b-3p TGFB2 -0.166697207281748 0.272022543069482 0.529934214584709 0.036730862150581 MirTarget;miRNATAP -0.318957683478265 9.08737208626492e-05 NA NA NA hsa-miR-33a-3p TGFB2 -0.683025859637737 1.01106097756419e-05 0.529934214584709 0.036730862150581 MirTarget;mirMAP -0.292910263006269 0.00021856118592367 NA NA NA hsa-miR-362-3p TGFB2 0.814007335895913 2.00108618836568e-09 0.529934214584709 0.036730862150581 miRanda -0.235702914624554 0.00870288726391307 NA NA NA hsa-miR-362-5p TGFB2 0.717921690799312 1.68392734504524e-05 0.529934214584709 0.036730862150581 MirTarget -0.184726662161473 0.0121843843046178 NA NA NA hsa-miR-548b-3p TGFB2 -0.0203576084717134 0.930819503166956 0.529934214584709 0.036730862150581 MirTarget -0.251413034966269 2.19240613879876e-06 NA NA NA hsa-miR-616-5p TGFB2 0.150569904638223 0.402836556304524 0.529934214584709 0.036730862150581 mirMAP -0.373291858655729 4.43049125036333e-08 NA NA NA hsa-miR-618 TGFB2 0.13539895350352 0.517145913114103 0.529934214584709 0.036730862150581 MirTarget;miRNATAP -0.323812991792447 9.41184108923406e-08 NA NA NA hsa-miR-151a-5p TGFB3 0.484893436232714 4.8995594459361e-06 -0.549558180002636 0.00349778458392359 MirTarget -0.493845417648935 6.80157351019684e-09 NA NA NA hsa-miR-22-3p TGFBR1 -0.628561621952407 1.33755558015523e-09 0.015032483953787 0.878256476667177 miRNATAP -0.104283638213843 0.0218609417498084 NA NA NA hsa-miR-106b-5p TGFBR2 0.648901865047099 8.24870862047885e-09 -0.522706741081292 3.47206054315007e-05 miRNATAP -0.368277930860382 4.29748674542316e-12 NA NA NA hsa-miR-130b-3p TGFBR2 0.687190305027546 0.000109068658562255 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.131252693120461 0.000144540113312326 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 0.698861147045461 2.43854106455398e-05 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.203186001893041 2.94531720390227e-08 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-18a-5p TGFBR2 0.918028187958706 1.90229510425322e-05 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate -0.192780882131928 5.02272007870357e-12 NA NA NA hsa-miR-19a-3p TGFBR2 1.01712596153672 2.57753201450625e-07 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.149425406079401 1.09582904607366e-06 NA NA NA hsa-miR-19b-3p TGFBR2 0.601279551368824 0.00016685097085251 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.16137896859351 2.62064707293945e-05 NA NA NA hsa-miR-20a-5p TGFBR2 0.854326758727003 5.04256669663285e-07 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.177394018081005 6.48951647363697e-07 NA NA NA hsa-miR-21-5p TGFBR2 1.51084295924322 1.54551622173259e-34 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.236840105633096 2.41705180023436e-07 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-301a-3p TGFBR2 0.842910511640361 1.43446467417891e-06 -0.522706741081292 3.47206054315007e-05 miRNATAP -0.183722985598573 1.11942744399345e-07 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-454-3p TGFBR2 0.668749059573955 2.42670710515113e-06 -0.522706741081292 3.47206054315007e-05 miRNATAP -0.109462345848673 0.0115970871562665 NA NA NA hsa-miR-501-3p TGFBR2 0.999540908940094 2.77358485581974e-11 -0.522706741081292 3.47206054315007e-05 TargetScan -0.116887889145825 0.0037841236086272 NA NA NA hsa-miR-590-5p TGFBR2 -0.103355559980404 0.310027295317092 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.253149374960949 3.5308611333711e-05 NA NA NA hsa-miR-92a-3p TGFBR2 0.212391012518195 0.134292268089997 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate -0.17351362748106 7.02401539230513e-05 NA NA NA hsa-miR-93-5p TGFBR2 1.39518349670953 2.84167728726712e-25 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.263677361634044 7.09611188180981e-10 NA NA NA hsa-miR-16-1-3p THBS1 0.392360028038559 0.00112481918108198 -2.1667874641621 3.47909831637717e-17 MirTarget -0.349993916076067 0.00122857732566393 NA NA NA hsa-miR-17-5p THBS1 0.698861147045461 2.43854106455398e-05 -2.1667874641621 3.47909831637717e-17 miRNAWalker2_validate -0.222517583477087 0.00443051973072606 NA NA NA hsa-miR-19a-3p THBS1 1.01712596153672 2.57753201450625e-07 -2.1667874641621 3.47909831637717e-17 MirTarget;mirMAP -0.266530076936376 3.91252800717626e-05 NA NA NA hsa-miR-19b-3p THBS1 0.601279551368824 0.00016685097085251 -2.1667874641621 3.47909831637717e-17 MirTarget;mirMAP -0.258570375211438 0.00144531729895803 NA NA NA hsa-miR-20a-5p THBS1 0.854326758727003 5.04256669663285e-07 -2.1667874641621 3.47909831637717e-17 miRNAWalker2_validate -0.298190202548282 7.75927048516442e-05 NA NA NA hsa-miR-32-5p THBS1 0.0806126674664016 0.548984992497432 -2.1667874641621 3.47909831637717e-17 mirMAP -0.415642500380362 1.79938285205236e-05 NA NA NA hsa-miR-455-5p THBS1 -0.270546034117157 0.0581320703577731 -2.1667874641621 3.47909831637717e-17 miRanda -0.233762708630074 0.0107946964967754 NA NA NA hsa-miR-576-5p THBS1 -0.377452008285847 0.00470735657343984 -2.1667874641621 3.47909831637717e-17 mirMAP -0.228830019937304 0.0194738176953478 NA NA NA hsa-miR-589-3p THBS1 1.16846704028095 5.88525574424201e-11 -2.1667874641621 3.47909831637717e-17 mirMAP -0.207376170994383 0.00450904846984429 NA NA NA hsa-miR-590-5p THBS1 -0.103355559980404 0.310027295317092 -2.1667874641621 3.47909831637717e-17 miRanda;mirMAP -0.273917755767687 0.0348626300140999 NA NA NA hsa-miR-616-5p THBS1 0.150569904638223 0.402836556304524 -2.1667874641621 3.47909831637717e-17 mirMAP -0.380879712809061 1.2036408171943e-07 NA NA NA hsa-miR-618 THBS1 0.13539895350352 0.517145913114103 -2.1667874641621 3.47909831637717e-17 MirTarget;PITA -0.212645935824045 0.000996351251570771 NA NA NA hsa-miR-664a-3p THBS1 0.485807855553031 0.000732553249798598 -2.1667874641621 3.47909831637717e-17 mirMAP -0.180728358556621 0.0463618027850176 NA NA NA hsa-miR-92a-3p THBS1 0.212391012518195 0.134292268089997 -2.1667874641621 3.47909831637717e-17 miRNAWalker2_validate -0.25627633804456 0.00550821085297264 NA NA NA hsa-miR-106b-5p THBS2 0.648901865047099 8.24870862047885e-09 -0.502816786435579 0.158172197533798 MirTarget -0.486129671276457 0.00142005744712669 NA NA NA hsa-miR-17-5p THBS2 0.698861147045461 2.43854106455398e-05 -0.502816786435579 0.158172197533798 MirTarget;TargetScan -0.379943541096311 0.0002503795908654 NA NA NA hsa-miR-20a-5p THBS2 0.854326758727003 5.04256669663285e-07 -0.502816786435579 0.158172197533798 MirTarget -0.441793484244088 1.04186713814831e-05 NA NA NA hsa-miR-32-3p THBS2 0.219109440121582 0.207217051619543 -0.502816786435579 0.158172197533798 miRNATAP -0.641167195268276 2.66066595937387e-10 NA NA NA hsa-miR-590-5p THBS2 -0.103355559980404 0.310027295317092 -0.502816786435579 0.158172197533798 miRanda -0.711273245527382 3.36369868701585e-05 NA NA NA hsa-miR-7-1-3p THBS2 -0.569105143287799 1.85297665041424e-05 -0.502816786435579 0.158172197533798 MirTarget;mirMAP -0.343348786927578 0.00830467804380644 NA NA NA hsa-miR-93-5p THBS2 1.39518349670953 2.84167728726712e-25 -0.502816786435579 0.158172197533798 MirTarget -0.59037311789499 1.04093973646049e-06 NA NA NA hsa-miR-3170 THBS3 -0.490667754008914 0.0102869987033346 0.736359717922504 1.32735428268107e-09 MirTarget -0.147643618350093 3.26408755400288e-06 NA NA NA hsa-miR-326 THBS3 -1.881935132554 1.68087316863775e-21 0.736359717922504 1.32735428268107e-09 PITA -0.189238431181079 3.98819872990696e-11 NA NA NA hsa-miR-330-5p THBS3 0.442231058604099 0.0053308560843808 0.736359717922504 1.32735428268107e-09 PITA;miRNATAP -0.11211646631826 0.00311770883033679 NA NA NA hsa-miR-550a-5p THBS3 0.156224023171823 0.282505553619229 0.736359717922504 1.32735428268107e-09 MirTarget -0.188790759957711 5.05581870085321e-06 NA NA NA hsa-miR-142-3p THBS4 -1.4243101967815 1.92609481097765e-14 5.61005547523483 2.66115801949053e-37 miRanda -1.10948136769617 1.72596454471113e-21 NA NA NA hsa-miR-107 TNF 0.241662461253461 0.0170788899505389 -1.0038697460391 4.57018472897375e-05 miRanda -0.319449999519582 0.00803039535673001 NA NA NA hsa-miR-361-5p TNF 0.233202959858696 0.00961572812255327 -1.0038697460391 4.57018472897375e-05 miRanda -0.383465948256239 0.00478262683574898 NA NA NA hsa-miR-17-5p ZFYVE9 0.698861147045461 2.43854106455398e-05 -0.342162134568488 0.000131097224279702 MirTarget;TargetScan;miRNATAP -0.173788606446126 1.21357715500259e-11 NA NA NA hsa-miR-19b-3p ZFYVE9 0.601279551368824 0.00016685097085251 -0.342162134568488 0.000131097224279702 MirTarget;miRNATAP -0.122904614326875 5.52992723661209e-06 NA NA NA hsa-miR-20a-5p ZFYVE9 0.854326758727003 5.04256669663285e-07 -0.342162134568488 0.000131097224279702 MirTarget;miRNATAP -0.14106974348761 1.81731985175181e-08 NA NA NA hsa-miR-222-3p ZFYVE9 1.08574156066353 1.76407192348131e-11 -0.342162134568488 0.000131097224279702 miRNAWalker2_validate -0.111055700895238 2.43473696929075e-05 NA NA NA hsa-miR-301a-3p ZFYVE9 0.842910511640361 1.43446467417891e-06 -0.342162134568488 0.000131097224279702 MirTarget;miRNATAP -0.115492725903964 2.49829587299703e-06 NA NA NA hsa-miR-93-5p ZFYVE9 1.39518349670953 2.84167728726712e-25 -0.342162134568488 0.000131097224279702 MirTarget;miRNATAP -0.106722079666797 0.000501230514136348 NA NA NA