miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-22-3p A4GNT -0.628561621952407 1.33755558015523e-09 -1.23788904255124 0.00041788399420954 MirTarget -0.757983744495537 3.22222834317288e-06 NA NA NA hsa-miR-22-3p ACLY -0.628561621952407 1.33755558015523e-09 1.02171988222232 3.44416828684327e-24 MirTarget -0.3392739255317 2.19128013453804e-12 27317765;26477310 Herein four different types of tumor cells including osteosarcoma prostate cervical and lung cancers were adopted in our study and we have demonstrated that miR-22 directly downregulated ACLY; Moreover miR-22 was proved to attenuate cancer cell proliferation and invasion as well as promote cell apoptosis via inhibiting ACLY; Additionally we confirmed the higher ACLY protein levels and the lower miR-22 expressions in hundreds of clinical samples of the four primary tumors and a negative correlation relationship between ACLY and miR-22 was clarified; These findings provide unequivocal proofs that miR-22 is responsible for the posttranscriptional regulation of ACLY which yields promising therapeutic effects in osteosarcoma prostate cervical and lung cancers;Within this cluster the cancer-associated and cardioprotective miR-22 was shown to repress fatty acid synthesis and elongation in tumour cells by targeting ATP citrate lyase and fatty acid elongase 6 as well as impairing mitochondrial one-carbon metabolism by suppression of methylene tetrahydrofolate dehydrogenase/cyclohydrolase ; sarcoma;breast cancer hsa-miR-22-3p ADAP1 -0.628561621952407 1.33755558015523e-09 -0.912994377393306 0.000838370647610513 mirMAP -0.517194793370134 4.72806138937299e-05 NA NA NA hsa-miR-22-3p ADCK2 -0.628561621952407 1.33755558015523e-09 0.527970568645926 2.76056833517351e-08 MirTarget -0.148833017896116 0.000868598405751244 NA NA NA hsa-miR-22-3p ADM2 -0.628561621952407 1.33755558015523e-09 1.7229047600607 3.16835442282685e-11 mirMAP -0.860142419333035 9.75102295625545e-13 NA NA NA hsa-miR-22-3p AGBL5 -0.628561621952407 1.33755558015523e-09 0.719216662189634 5.45155911410886e-12 MirTarget;miRNATAP -0.326030595475448 1.97624884231594e-11 NA NA NA hsa-miR-22-3p ALMS1 -0.628561621952407 1.33755558015523e-09 0.541093798179561 5.72657368729648e-10 miRNAWalker2_validate -0.230976896482156 1.38815285042874e-08 NA NA NA hsa-miR-22-3p ANXA13 -0.628561621952407 1.33755558015523e-09 -0.6268734906577 0.168001651544019 MirTarget -0.718205819517083 0.000663102035104186 NA NA NA hsa-miR-22-3p ARFIP2 -0.628561621952407 1.33755558015523e-09 0.369397226468017 2.03018749407951e-06 MirTarget;miRNATAP -0.172782402464626 1.66028582061249e-06 NA NA NA hsa-miR-22-3p ARID3B -0.628561621952407 1.33755558015523e-09 0.456196233773583 0.000205068052872381 MirTarget;miRNATAP -0.386156448978086 5.74346279758181e-12 NA NA NA hsa-miR-22-3p ARID5B -0.628561621952407 1.33755558015523e-09 -0.51790455974164 0.000116493206015505 miRNAWalker2_validate -0.157315040344983 0.0124164851604827 NA NA NA hsa-miR-22-3p ASB6 -0.628561621952407 1.33755558015523e-09 0.348902554082249 2.67213744682496e-06 MirTarget -0.211182710359997 6.0831236206723e-10 NA NA NA hsa-miR-22-3p ATP9A -0.628561621952407 1.33755558015523e-09 0.352728989524001 0.0303175660824993 MirTarget -0.315652194359881 2.78135873684933e-05 NA NA NA hsa-miR-22-3p B4GALT5 -0.628561621952407 1.33755558015523e-09 -0.523612200569853 3.66546987358603e-06 MirTarget -0.214551137890923 4.82028662674748e-05 NA NA NA hsa-miR-22-3p BCL9 -0.628561621952407 1.33755558015523e-09 1.17619476675548 1.43287619580645e-16 MirTarget;miRNATAP -0.60774329716253 2.09794172709502e-20 NA NA NA hsa-miR-22-3p BIN1 -0.628561621952407 1.33755558015523e-09 0.290685942558418 0.0248147477384824 MirTarget;miRNATAP -0.140806137086349 0.019548106049917 NA NA NA hsa-miR-22-3p BMP7 -0.628561621952407 1.33755558015523e-09 0.826802462156244 0.0488671273441991 miRNAWalker2_validate;miRTarBase -0.870526640067938 7.19988594035658e-06 NA NA NA hsa-miR-22-3p BRSK2 -0.628561621952407 1.33755558015523e-09 1.39040613056321 0.000399787455740901 MirTarget;miRNATAP -1.06517117892854 3.87751553268348e-09 NA NA NA hsa-miR-22-3p BRWD3 -0.628561621952407 1.33755558015523e-09 0.097389343514537 0.536703137535803 MirTarget;miRNATAP -0.221154229709889 0.00247684636207858 NA NA NA hsa-miR-22-3p BSPRY -0.628561621952407 1.33755558015523e-09 -0.0928026476573471 0.79034917414925 MirTarget -0.856779870210313 8.76181975482625e-08 NA NA NA hsa-miR-22-3p BTBD10 -0.628561621952407 1.33755558015523e-09 0.283901647603299 2.32887164783357e-05 MirTarget;miRNATAP -0.145164094172021 2.80630328255611e-06 NA NA NA hsa-miR-22-3p BTF3 -0.628561621952407 1.33755558015523e-09 0.142993892406527 0.0974444778658895 miRNAWalker2_validate -0.106560991672511 0.00766410001359619 NA NA NA hsa-miR-22-3p BUB1B -0.628561621952407 1.33755558015523e-09 3.85682830100864 2.02974032557381e-43 miRNAWalker2_validate -1.59565755962297 8.34276186949843e-33 NA NA NA hsa-miR-22-3p C17orf58 -0.628561621952407 1.33755558015523e-09 0.657261428051333 2.02698800942325e-09 miRNATAP -0.166024925191235 0.00134796720085109 NA NA NA hsa-miR-22-3p C20orf194 -0.628561621952407 1.33755558015523e-09 0.238037680827578 0.0793767985288294 mirMAP -0.276300599199593 1.01130736969848e-05 NA NA NA hsa-miR-22-3p CBFA2T2 -0.628561621952407 1.33755558015523e-09 1.20918131407154 1.46538376039906e-30 mirMAP -0.525954225259893 2.22006067990645e-26 NA NA NA hsa-miR-22-3p CBL -0.628561621952407 1.33755558015523e-09 0.0549640409712908 0.654706328872111 MirTarget -0.291142747541843 2.34921546506491e-07 NA NA NA hsa-miR-22-3p CBX6 -0.628561621952407 1.33755558015523e-09 -0.135925898836227 0.562356772831778 MirTarget -0.47007463368136 1.40321135669485e-05 NA NA NA hsa-miR-22-3p CCNA2 -0.628561621952407 1.33755558015523e-09 3.36794922367745 6.53886370047174e-43 MirTarget -1.21746436700899 3.56641376559019e-24 25596928 The sequence of miR-22 which is conserved in mice rats humans and other mammalians aligns with the sequence of 3'-UTR of CCNA2; Chenodeoxycholic acid treatment and miR-22 mimics reduced CCNA2 protein and increased the number of G0/G1 Huh7 and HCT116 cells; In humans the expression levels of miR-22 and CCNA2 are inversely correlated in liver and colon cancers liver cancer hsa-miR-22-3p CCNT2 -0.628561621952407 1.33755558015523e-09 -0.125072957809514 0.25328235743992 miRNAWalker2_validate -0.127867039216519 0.0118120602988572 NA NA NA hsa-miR-22-3p CDCA7L -0.628561621952407 1.33755558015523e-09 0.484426770962648 0.01421551674655 MirTarget -0.658238438147483 1.96782014486994e-13 NA NA NA hsa-miR-22-3p CLIP2 -0.628561621952407 1.33755558015523e-09 0.6241982550792 0.00363613390848369 MirTarget -0.362030555351859 0.000286887157969296 NA NA NA hsa-miR-22-3p COPS7B -0.628561621952407 1.33755558015523e-09 0.641973815480622 1.99581786116502e-17 MirTarget;miRNATAP -0.344397498441643 1.82419584485996e-23 NA NA NA hsa-miR-22-3p CREB1 -0.628561621952407 1.33755558015523e-09 -0.00947108171252431 0.883800737430634 MirTarget -0.207046355261965 1.09327700723103e-12 NA NA NA hsa-miR-22-3p CSMD2 -0.628561621952407 1.33755558015523e-09 2.31943623170624 1.26374709514885e-11 MirTarget -0.446310119425602 0.00632662825956576 NA NA NA hsa-miR-22-3p CSNK2A1 -0.628561621952407 1.33755558015523e-09 0.311613292322925 6.17228757339028e-05 miRNAWalker2_validate -0.313593609077037 1.67312457705441e-19 NA NA NA hsa-miR-22-3p CTSC -0.628561621952407 1.33755558015523e-09 0.237981093984275 0.171373931043568 miRNATAP -0.296784656468712 0.000228832775353446 NA NA NA hsa-miR-22-3p DAGLA -0.628561621952407 1.33755558015523e-09 1.16197262256378 7.56867119602314e-06 MirTarget -0.602309700628948 6.05717744460406e-07 NA NA NA hsa-miR-22-3p DIDO1 -0.628561621952407 1.33755558015523e-09 0.247823746583441 0.000790432489634158 mirMAP -0.195959307292371 6.57114020126199e-09 NA NA NA hsa-miR-22-3p DNAJC5 -0.628561621952407 1.33755558015523e-09 0.729723241275518 1.53708391771805e-17 MirTarget -0.280215794966686 3.70875988851115e-12 NA NA NA hsa-miR-22-3p DPF2 -0.628561621952407 1.33755558015523e-09 0.619896877893455 5.94406643109522e-20 MirTarget;miRNATAP -0.28876084710522 3.46666968524835e-20 NA NA NA hsa-miR-22-3p DPM2 -0.628561621952407 1.33755558015523e-09 0.583482602426183 4.51678867313219e-07 MirTarget -0.240236149769498 8.64957563742946e-06 NA NA NA hsa-miR-22-3p DSTYK -0.628561621952407 1.33755558015523e-09 1.00504202460505 2.41375496861128e-19 MirTarget -0.268557628814591 5.83067837163933e-07 NA NA NA hsa-miR-22-3p E2F2 -0.628561621952407 1.33755558015523e-09 2.82262179260901 6.90997126839698e-33 miRNAWalker2_validate -1.17700583503314 1.01771679679134e-25 NA NA NA hsa-miR-22-3p EDARADD -0.628561621952407 1.33755558015523e-09 0.941526304158294 3.91500041594882e-05 MirTarget -0.454895216468376 2.01401301910496e-05 NA NA NA hsa-miR-22-3p EDC3 -0.628561621952407 1.33755558015523e-09 0.728251649618274 7.59128130821528e-26 miRNAWalker2_validate;MirTarget -0.315096338860665 2.33237262059117e-22 NA NA NA hsa-miR-22-3p EFR3B -0.628561621952407 1.33755558015523e-09 0.419893657122922 0.00614160314164536 MirTarget -0.219583722430696 0.00207959247838411 NA NA NA hsa-miR-22-3p ENO1 -0.628561621952407 1.33755558015523e-09 0.286010658022283 0.0286377169754827 MirTarget -0.168693907018779 0.00549645552510979 NA NA NA hsa-miR-22-3p EP300 -0.628561621952407 1.33755558015523e-09 -0.200382966790078 0.0704945874784134 MirTarget;miRNATAP -0.102672783880902 0.0463193353503437 NA NA NA hsa-miR-22-3p ERBB3 -0.628561621952407 1.33755558015523e-09 0.582300618829416 0.00108939534898452 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.457910025020904 2.44402177433386e-08 22484852;22510010;21057539;27569217 Tumor suppressor miR 22 suppresses lung cancer cell progression through post transcriptional regulation of ErbB3; Furthermore miR-22 was demonstrated to inhibit the expression of ErbB3 through post-transcriptional regulation via binding to ErbB3 3'-UTR; miR-22 exhibited excellent anti-lung cancer activity in vitro and in vivo and post-transcriptional regulation of ErbB3 might be a potential mechanism;Transfected miR-22 Y79 cells inhibited the cell proliferation and reduced the migration and erythoblastic leukemia viral oncogene homolog 3 Erbb3 was confirmed to be the target gene of miR-22;These metastatic cells expressed higher levels of putative/proven miR-22 target oncogenes ERBB3 CDC25C and EVI-1; Introduction of miR-22 into cancer cells reduced the levels of ERBB3 and EVI-1 as well as phospho-AKT an EVI-1 downstream target;Finally we demonstrated the ability of miR-22 to intercept and overcome the intrinsic resistance to MEK inhibition based on ERBB3 upregulation progression;;;drug resistance lung cancer;retinoblastoma;breast cancer;sarcoma hsa-miR-22-3p FAM49B -0.628561621952407 1.33755558015523e-09 0.706283783396553 6.55052138725098e-10 MirTarget;miRNATAP -0.509517382936633 3.53451859772129e-23 NA NA NA hsa-miR-22-3p FAM53C -0.628561621952407 1.33755558015523e-09 0.378970564897856 1.01004042272512e-07 MirTarget;miRNATAP -0.139887229772567 2.49394621040499e-05 NA NA NA hsa-miR-22-3p FBRS -0.628561621952407 1.33755558015523e-09 0.349598040715293 1.04903156229209e-08 miRNATAP -0.158460911378469 2.04679131725148e-08 NA NA NA hsa-miR-22-3p FBXL19 -0.628561621952407 1.33755558015523e-09 1.09129763767905 3.05430880690495e-25 miRNATAP -0.493412956296607 9.23574372984268e-24 NA NA NA hsa-miR-22-3p FGD6 -0.628561621952407 1.33755558015523e-09 0.314033910840616 0.0439181907931429 MirTarget -0.36379646593339 3.89839311925505e-07 NA NA NA hsa-miR-22-3p FIBCD1 -0.628561621952407 1.33755558015523e-09 1.88653727679798 2.70562496772063e-07 MirTarget -0.622454581893039 0.000308798089198855 NA NA NA hsa-miR-22-3p FMNL2 -0.628561621952407 1.33755558015523e-09 0.0524311775006261 0.807723354715146 MirTarget -0.341870673116907 0.000611720873197547 NA NA NA hsa-miR-22-3p FOXP1 -0.628561621952407 1.33755558015523e-09 0.13330392204595 0.183148877784263 miRNAWalker2_validate;miRNATAP -0.14012379996127 0.0025081726904681 NA NA NA hsa-miR-22-3p FRAT2 -0.628561621952407 1.33755558015523e-09 0.225546147167742 0.0512402780577874 miRNAWalker2_validate;MirTarget;miRNATAP -0.232862193711047 1.27800322792138e-05 NA NA NA hsa-miR-22-3p FUBP1 -0.628561621952407 1.33755558015523e-09 0.247717515860818 0.0219139935532019 miRNAWalker2_validate -0.3578485425961 2.41972252641971e-13 NA NA NA hsa-miR-22-3p GALNT4 -0.628561621952407 1.33755558015523e-09 -0.645164898878942 1.29772088330393e-07 MirTarget -0.182588693417317 0.00149712126928832 NA NA NA hsa-miR-22-3p GIGYF2 -0.628561621952407 1.33755558015523e-09 -0.0175797030709068 0.786910496545841 MirTarget -0.13113703210236 1.03421511313271e-05 NA NA NA hsa-miR-22-3p GLIS2 -0.628561621952407 1.33755558015523e-09 0.562379009835414 0.0131617515622673 miRNAWalker2_validate -0.603412923614478 6.71621144890677e-09 NA NA NA hsa-miR-22-3p GMEB2 -0.628561621952407 1.33755558015523e-09 0.649674999709834 6.33331854886269e-19 mirMAP -0.264821946998705 1.11977129527856e-14 NA NA NA hsa-miR-22-3p GNA12 -0.628561621952407 1.33755558015523e-09 0.601225554154701 1.98193833212861e-09 mirMAP -0.113072496008674 0.0171772867864185 NA NA NA hsa-miR-22-3p GNB1L -0.628561621952407 1.33755558015523e-09 0.972387895486426 1.58066300637692e-14 mirMAP -0.248990930226969 3.78707138756038e-05 NA NA NA hsa-miR-22-3p GPBP1 -0.628561621952407 1.33755558015523e-09 0.368570720975697 5.36942235456777e-11 MirTarget;miRNATAP -0.143290415722195 4.12057583035505e-08 NA NA NA hsa-miR-22-3p GPSM2 -0.628561621952407 1.33755558015523e-09 1.45389191030237 4.5650425831655e-20 MirTarget -0.822983104559553 2.407740802596e-30 NA NA NA hsa-miR-22-3p H3F3B -0.628561621952407 1.33755558015523e-09 0.00746540420898256 0.925845396816961 miRNAWalker2_validate;MirTarget -0.169578495412915 3.93985786029077e-06 NA NA NA hsa-miR-22-3p H3F3C -0.628561621952407 1.33755558015523e-09 -0.330118832016397 0.000851762595089535 MirTarget -0.113189508359172 0.0142039105679907 NA NA NA hsa-miR-22-3p HDAC4 -0.628561621952407 1.33755558015523e-09 1.00691818288109 6.96034330486747e-18 miRNAWalker2_validate;miRTarBase;miRNATAP -0.389687524652593 1.64203762151771e-12 20842113 Furthermore histone deacetylase 4 HDAC4 known to have critical roles in cancer development was proved to be directly targeted and regulated by miR-22; Furthermore HDAC4 was upregulated in miR-22-downregulated HCC tissues suggesting that downregulation of miR-22 might participate in HCC carcinogenesis and progression through potentiation of HDAC4 expression progression;tumorigenesis liver cancer hsa-miR-22-3p HES2 -0.628561621952407 1.33755558015523e-09 1.80546502926672 2.25475279863592e-08 mirMAP -0.590307675013484 0.000104116866713427 NA NA NA hsa-miR-22-3p HIF1AN -0.628561621952407 1.33755558015523e-09 0.594006229178836 2.59789157148843e-12 MirTarget -0.223127731050745 2.11880105411948e-08 NA NA NA hsa-miR-22-3p HNF4G -0.628561621952407 1.33755558015523e-09 -0.507584088404726 0.00622193923962689 MirTarget -0.321339599467359 0.000192121684204238 NA NA NA hsa-miR-22-3p HNRNPH1 -0.628561621952407 1.33755558015523e-09 0.417091180278661 1.28835765588824e-07 miRNATAP -0.333035214469382 4.64729140764049e-21 NA NA NA hsa-miR-22-3p HNRNPUL2 -0.628561621952407 1.33755558015523e-09 0.275874937555984 4.47000347686817e-06 miRNATAP -0.113447985172238 4.63345214846456e-05 NA NA NA hsa-miR-22-3p HOMER1 -0.628561621952407 1.33755558015523e-09 -0.0763641412081514 0.796151529043688 MirTarget -0.523755417860633 0.000127608919369781 NA NA NA hsa-miR-22-3p HSF2BP -0.628561621952407 1.33755558015523e-09 2.11372138377908 3.28977187814902e-22 MirTarget -0.970967084029477 1.5698163165588e-21 NA NA NA hsa-miR-22-3p HSPA1B -0.628561621952407 1.33755558015523e-09 0.500062250723722 0.0177938871093333 miRNAWalker2_validate -0.300778981891712 0.00218774237452039 NA NA NA hsa-miR-22-3p HTR3A -0.628561621952407 1.33755558015523e-09 0.745429213146013 0.031589854701702 MirTarget -0.599987805556474 0.000192493860174581 NA NA NA hsa-miR-22-3p HUNK -0.628561621952407 1.33755558015523e-09 -0.720733679971585 0.0531352542804175 MirTarget -0.970740426383009 1.36672476534403e-08 NA NA NA hsa-miR-22-3p IKZF4 -0.628561621952407 1.33755558015523e-09 0.318939579885376 0.000894578223191946 MirTarget;miRNATAP -0.226018990469874 3.22922606728299e-07 NA NA NA hsa-miR-22-3p IL17RD -0.628561621952407 1.33755558015523e-09 -0.125343297177237 0.609800523271957 MirTarget;miRNATAP -0.300657850537969 0.00841501882510816 NA NA NA hsa-miR-22-3p IL27RA -0.628561621952407 1.33755558015523e-09 0.515544442009422 0.00115640512064187 MirTarget -0.346187183868099 2.42215428437372e-06 NA NA NA hsa-miR-22-3p IPO7 -0.628561621952407 1.33755558015523e-09 -0.12637692697336 0.126888447462856 MirTarget;miRNATAP -0.177353206668931 3.02808831022736e-06 NA NA NA hsa-miR-22-3p IRF5 -0.628561621952407 1.33755558015523e-09 0.552507085098635 2.3571666935193e-06 miRNAWalker2_validate -0.16870606403995 0.00212107282013697 NA NA NA hsa-miR-22-3p ISY1 -0.628561621952407 1.33755558015523e-09 0.204897528689875 0.000169687942834432 mirMAP -0.181334062542812 1.40477369625211e-13 NA NA NA hsa-miR-22-3p JARID2 -0.628561621952407 1.33755558015523e-09 0.389563833569475 2.66930964150282e-05 miRNATAP -0.35698150181653 1.15371368306536e-17 NA NA NA hsa-miR-22-3p KCTD10 -0.628561621952407 1.33755558015523e-09 0.322240866701679 3.57260096087696e-06 MirTarget -0.14809467019834 4.26886919305759e-06 NA NA NA hsa-miR-22-3p KDM3A -0.628561621952407 1.33755558015523e-09 0.260290611309434 0.00489255318634796 MirTarget;miRNATAP -0.295146823057543 1.94964877337518e-12 NA NA NA hsa-miR-22-3p KIAA1257 -0.628561621952407 1.33755558015523e-09 0.430040484019483 0.109863886905169 mirMAP -0.399815037371222 0.00136940900351629 NA NA NA hsa-miR-22-3p KIF21B -0.628561621952407 1.33755558015523e-09 1.1784578803772 5.28752515379585e-07 mirMAP -0.224386995232712 0.0431768565312827 NA NA NA hsa-miR-22-3p LAMC1 -0.628561621952407 1.33755558015523e-09 1.18164580989765 3.65525462453826e-17 MirTarget;miRNATAP -0.444929117565246 2.00326518461981e-11 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-22-3p LEMD3 -0.628561621952407 1.33755558015523e-09 -0.241034061384027 0.00152124310234342 miRNAWalker2_validate -0.107658291284079 0.002269801038627 NA NA NA hsa-miR-22-3p LIG3 -0.628561621952407 1.33755558015523e-09 0.616420814558472 9.14643546527433e-15 MirTarget -0.227303215557336 1.23973044443593e-09 NA NA NA hsa-miR-22-3p LRRC1 -0.628561621952407 1.33755558015523e-09 2.13537964746555 1.21344895597941e-11 miRNAWalker2_validate;miRNATAP -1.33807961642952 1.10003477741159e-20 NA NA NA hsa-miR-22-3p LRRC14 -0.628561621952407 1.33755558015523e-09 1.36580119828543 4.14163388274102e-35 mirMAP -0.337930607447085 7.69014135080401e-10 NA NA NA hsa-miR-22-3p LRRC59 -0.628561621952407 1.33755558015523e-09 0.441548574766935 5.64199580946937e-09 MirTarget -0.157539038471435 8.77828182597633e-06 NA NA NA hsa-miR-22-3p MAP3K3 -0.628561621952407 1.33755558015523e-09 0.0104889868708602 0.888426899769504 MirTarget;miRNATAP -0.101580693430174 0.00322006100695006 NA NA NA hsa-miR-22-3p MAPK8IP3 -0.628561621952407 1.33755558015523e-09 1.01234491290533 3.03085078878221e-14 MirTarget -0.314115386963014 6.92995851833492e-07 NA NA NA hsa-miR-22-3p MAT2A -0.628561621952407 1.33755558015523e-09 -0.00978487745452306 0.921857916340321 MirTarget;miRNATAP -0.149826979363703 0.00115113941390104 NA NA NA hsa-miR-22-3p MDC1 -0.628561621952407 1.33755558015523e-09 0.593059210356619 3.44429003700184e-09 MirTarget -0.421962880862876 1.16365039807604e-20 NA NA NA hsa-miR-22-3p MECOM -0.628561621952407 1.33755558015523e-09 0.959512171082984 9.09579943703071e-08 miRNATAP -0.180980334358813 0.0330564397272789 NA NA NA hsa-miR-22-3p MECP2 -0.628561621952407 1.33755558015523e-09 0.263893569030019 0.000429500323071978 miRNATAP -0.142492779038539 3.92508365383253e-05 NA NA NA hsa-miR-22-3p MED22 -0.628561621952407 1.33755558015523e-09 0.901475361439055 2.19971977737607e-20 mirMAP -0.424105674287609 6.98797878657253e-21 NA NA NA hsa-miR-22-3p MEIS2 -0.628561621952407 1.33755558015523e-09 0.156457406703811 0.32841086989024 MirTarget -0.230129435187299 0.00193262537963104 NA NA NA hsa-miR-22-3p MFGE8 -0.628561621952407 1.33755558015523e-09 0.980930670797802 1.45880246249867e-09 MirTarget -0.238085657235211 0.00193537544559976 NA NA NA hsa-miR-22-3p MTF2 -0.628561621952407 1.33755558015523e-09 0.168133266471024 0.0710258930647526 MirTarget;miRNATAP -0.420620426774187 5.35751166075758e-25 NA NA NA hsa-miR-22-3p MTMR2 -0.628561621952407 1.33755558015523e-09 0.400709772822859 0.00100054348711912 MirTarget -0.486326206527455 4.13006186719076e-19 NA NA NA hsa-miR-22-3p MURC -0.628561621952407 1.33755558015523e-09 1.57695437107485 4.62997524764162e-16 MirTarget -0.374352380694474 5.94378659968815e-05 NA NA NA hsa-miR-22-3p MXD1 -0.628561621952407 1.33755558015523e-09 -0.226196114969913 0.0553256279722308 miRNATAP -0.183533591163384 0.000792268567518321 NA NA NA hsa-miR-22-3p MYCBP -0.628561621952407 1.33755558015523e-09 0.270320437141615 0.00287712114096272 miRNAWalker2_validate;miRTarBase -0.165311638292797 8.19713312974238e-05 NA NA NA hsa-miR-22-3p MYO6 -0.628561621952407 1.33755558015523e-09 -0.0102768547102698 0.938333318335632 miRNAWalker2_validate -0.166601119163228 0.00683858992233183 NA NA NA hsa-miR-22-3p N4BP3 -0.628561621952407 1.33755558015523e-09 1.8217286140426 3.52289215295134e-19 MirTarget -0.613556499852934 2.69873502614545e-10 NA NA NA hsa-miR-22-3p NET1 -0.628561621952407 1.33755558015523e-09 -0.257283308116178 0.00689999829857687 MirTarget;miRNATAP -0.150054908310932 0.00067769750424805 NA NA NA hsa-miR-22-3p NHP2 -0.628561621952407 1.33755558015523e-09 0.768665559696117 4.38464204320506e-12 MirTarget -0.119099484007538 0.0246049331072368 NA NA NA hsa-miR-22-3p NPNT -0.628561621952407 1.33755558015523e-09 0.531754123141975 0.0583025915811082 miRNATAP -0.591022017306554 5.17736190051399e-06 NA NA NA hsa-miR-22-3p NRAS -0.628561621952407 1.33755558015523e-09 0.301156333096785 0.000285671613438218 MirTarget;miRNATAP -0.287363482934569 1.84836871548684e-14 NA NA NA hsa-miR-22-3p NUP210 -0.628561621952407 1.33755558015523e-09 0.782751605380779 4.03899169947893e-10 MirTarget -0.544258232517297 5.70520113854534e-22 NA NA NA hsa-miR-22-3p NUP214 -0.628561621952407 1.33755558015523e-09 0.173705439633182 0.00487968779533919 miRNAWalker2_validate -0.116852971343319 3.79887087129694e-05 20081105 In addition to these specific effects reversing the expression of mir-22 and the putative oncogene mir-182 had widespread effects on target and nontarget gene populations that ultimately caused a global shift in the cancer gene signature toward a more normal state ovarian cancer hsa-miR-22-3p NUSAP1 -0.628561621952407 1.33755558015523e-09 2.13379528300653 8.33883903420606e-30 MirTarget -1.02004256462908 1.58747283631234e-31 NA NA NA hsa-miR-22-3p ORAI2 -0.628561621952407 1.33755558015523e-09 0.147939436354318 0.336648923993268 mirMAP -0.278716189695018 8.92762061603641e-05 NA NA NA hsa-miR-22-3p OTUD6B -0.628561621952407 1.33755558015523e-09 0.720488164691301 4.05780168803687e-11 MirTarget -0.201951474239163 9.19412820360731e-05 NA NA NA hsa-miR-22-3p PACS2 -0.628561621952407 1.33755558015523e-09 0.778484820044494 1.37066720672879e-21 mirMAP -0.206252178230641 1.54088084960917e-07 NA NA NA hsa-miR-22-3p PHC1 -0.628561621952407 1.33755558015523e-09 -0.347877085596097 0.0226840114207948 MirTarget -0.186166862992157 0.00880587809171317 NA NA NA hsa-miR-22-3p PIK3R6 -0.628561621952407 1.33755558015523e-09 0.969138287277783 7.3402634399105e-08 MirTarget -0.377891620422119 7.523159993852e-06 NA NA NA hsa-miR-22-3p PIP4K2B -0.628561621952407 1.33755558015523e-09 0.57569512577541 7.2526318631119e-15 MirTarget -0.279872359509357 2.6528415155591e-16 NA NA NA hsa-miR-22-3p PLAGL2 -0.628561621952407 1.33755558015523e-09 0.336986331692996 0.00300478705110513 miRNATAP -0.49446173559661 6.62868626684058e-23 NA NA NA hsa-miR-22-3p PLEKHA6 -0.628561621952407 1.33755558015523e-09 -0.153623055388472 0.297248815212102 MirTarget -0.144389336471717 0.0351311346035487 NA NA NA hsa-miR-22-3p PLEKHG4B -0.628561621952407 1.33755558015523e-09 0.790427207306621 0.0337710604622749 mirMAP -0.392618049457517 0.0237878097238875 NA NA NA hsa-miR-22-3p PMAIP1 -0.628561621952407 1.33755558015523e-09 -0.747631575480281 0.00470707404300575 MirTarget -0.381734668155031 0.00195757535155073 NA NA NA hsa-miR-22-3p POGK -0.628561621952407 1.33755558015523e-09 0.625888080106357 7.94900288255434e-11 MirTarget -0.446982533653223 3.21619717533144e-25 NA NA NA hsa-miR-22-3p PRDM4 -0.628561621952407 1.33755558015523e-09 0.265885941113794 0.000114217472510259 MirTarget -0.236262394757966 3.13047564505574e-14 NA NA NA hsa-miR-22-3p PRPF38A -0.628561621952407 1.33755558015523e-09 0.132354587215381 0.0606625222160112 MirTarget -0.317631976992598 5.42994746172623e-25 NA NA NA hsa-miR-22-3p PRRT2 -0.628561621952407 1.33755558015523e-09 1.34759472909516 5.04177063186626e-12 miRNATAP -0.592863409282648 8.37096483664826e-11 NA NA NA hsa-miR-22-3p PRX -0.628561621952407 1.33755558015523e-09 0.973700085344309 4.95602829998367e-13 mirMAP -0.360653610242686 1.35124526228895e-08 NA NA NA hsa-miR-22-3p PTP4A3 -0.628561621952407 1.33755558015523e-09 1.98288212330108 7.95134226476913e-18 MirTarget -0.73318466352193 2.02657688165976e-11 NA NA NA hsa-miR-22-3p PTPN1 -0.628561621952407 1.33755558015523e-09 0.120906481171513 0.121843267942662 miRNATAP -0.112040517956683 0.00190958649896157 NA NA NA hsa-miR-22-3p PURB -0.628561621952407 1.33755558015523e-09 0.173224214520089 0.00583309998222054 miRNATAP -0.200754077920583 1.35899860398083e-12 NA NA NA hsa-miR-22-3p RAB11FIP4 -0.628561621952407 1.33755558015523e-09 1.54437373311846 7.02562100479325e-17 miRNATAP -0.613329818912497 2.11890571918004e-12 NA NA NA hsa-miR-22-3p RAPGEFL1 -0.628561621952407 1.33755558015523e-09 0.512757940233236 0.00610377319567469 miRNATAP -0.51775343173426 1.52209810294103e-09 NA NA NA hsa-miR-22-3p RBM33 -0.628561621952407 1.33755558015523e-09 0.427922714212897 1.39440515934481e-10 mirMAP -0.171439348530916 3.43121068741502e-08 NA NA NA hsa-miR-22-3p RBM39 -0.628561621952407 1.33755558015523e-09 0.351437545522261 1.43446113228632e-09 miRNAWalker2_validate -0.174657053765282 6.25633863406371e-11 NA NA NA hsa-miR-22-3p RCC2 -0.628561621952407 1.33755558015523e-09 0.694107774930846 9.98545852945955e-11 MirTarget -0.595996903862099 1.53043629204678e-37 NA NA NA hsa-miR-22-3p RFXANK -0.628561621952407 1.33755558015523e-09 1.00865411998151 7.22407114441766e-17 MirTarget -0.352868833389847 7.56028574946096e-10 NA NA NA hsa-miR-22-3p RNF38 -0.628561621952407 1.33755558015523e-09 -0.0757478216560479 0.426628146490064 miRNATAP -0.202075659351547 3.84823041469215e-06 NA NA NA hsa-miR-22-3p RPL24 -0.628561621952407 1.33755558015523e-09 0.120262532585365 0.315518076707735 miRNAWalker2_validate -0.151858108380669 0.00627478435412543 NA NA NA hsa-miR-22-3p RPL35A -0.628561621952407 1.33755558015523e-09 0.404680142512632 0.000571077401599864 miRNAWalker2_validate -0.29209180850244 6.77443397961461e-08 NA NA NA hsa-miR-22-3p RPS2 -0.628561621952407 1.33755558015523e-09 0.390157810623333 0.00217385247664797 miRNAWalker2_validate -0.315366051792702 7.31178228398205e-08 NA NA NA hsa-miR-22-3p RPS4X -0.628561621952407 1.33755558015523e-09 0.174299264770649 0.133780359830453 miRNAWalker2_validate -0.252319186476883 2.36646542616347e-06 NA NA NA hsa-miR-22-3p RPS6KC1 -0.628561621952407 1.33755558015523e-09 0.621986705258543 1.2828878400174e-11 MirTarget -0.169182524994923 9.96706693454828e-05 NA NA NA hsa-miR-22-3p RPSA -0.628561621952407 1.33755558015523e-09 0.668412826759986 4.11902955873553e-07 miRNAWalker2_validate -0.440746662387218 3.19403260259865e-13 NA NA NA hsa-miR-22-3p RUFY2 -0.628561621952407 1.33755558015523e-09 0.393858751477356 6.55612421164772e-06 MirTarget -0.188717051625444 3.26051497949736e-06 NA NA NA hsa-miR-22-3p SLC22A23 -0.628561621952407 1.33755558015523e-09 0.632125395741205 5.61389746801226e-07 MirTarget -0.209353504982945 0.000411550628196322 NA NA NA hsa-miR-22-3p SLC2A1 -0.628561621952407 1.33755558015523e-09 0.341472370166429 0.158776644395418 miRNATAP -0.485546437726885 1.42965222412711e-05 25304371 In this study we found that GLUT1 is a direct target of miR-22; The ectopic expression of miR-22 inhibited breast cancer cell proliferation and invasion by targeting GLUT1; A reverse correlation between the expression of miR-22 and GLUT1 was observed in breast cancer tissue samples breast cancer hsa-miR-22-3p SLC39A10 -0.628561621952407 1.33755558015523e-09 1.03363681046182 2.86152302488301e-10 miRNATAP -0.487528817731663 1.70740154066531e-10 NA NA NA hsa-miR-22-3p SLC9A1 -0.628561621952407 1.33755558015523e-09 0.165675299240051 0.168213985657365 MirTarget -0.164510525556614 0.00316600761203508 NA NA NA hsa-miR-22-3p SMG7 -0.628561621952407 1.33755558015523e-09 0.512333178705147 4.03770030415481e-13 miRNATAP -0.145589211922376 1.2932423886804e-05 NA NA NA hsa-miR-22-3p SNX22 -0.628561621952407 1.33755558015523e-09 0.824833032857074 3.36117280226991e-07 mirMAP -0.166598063104904 0.0290228795692706 NA NA NA hsa-miR-22-3p SNX30 -0.628561621952407 1.33755558015523e-09 0.0514003764836284 0.625541828460129 miRNATAP -0.216485499697792 7.78401827100567e-06 NA NA NA hsa-miR-22-3p SOX13 -0.628561621952407 1.33755558015523e-09 0.713864896374115 5.5028190432502e-13 MirTarget -0.272059066558822 4.93322077720827e-09 NA NA NA hsa-miR-22-3p SP1 -0.628561621952407 1.33755558015523e-09 0.0334930719412458 0.566652742155962 miRNAWalker2_validate -0.168203459931884 1.70521621996518e-10 23529765;24906624 miR 22 is down regulated in gastric cancer and its overexpression inhibits cell migration and invasion via targeting transcription factor Sp1; Moreover we also showed that Sp1 was negatively regulated by miR-22 at the posttranscriptional level via a specific target site within the 3'UTR by luciferase reporter assay; The expression of Sp1 was inversely correlated with miR-22 expression in gastric cancer tissues and knockdown of Sp1 by siRNA inhibited cell malignant behaviors; Thus our findings suggest that miR-22 acts as tumor suppressor by targeting the Sp1 gene and inhibiting gastric cancer cell migration and invasion;We also determined that miR-22 could indirectly participate in CD147 modulation by downregulating Sp1 expression cell migration;malignant trasformation; gastric cancer;breast cancer hsa-miR-22-3p SPOCK1 -0.628561621952407 1.33755558015523e-09 2.53504187150893 2.13962835594159e-10 MirTarget -0.502709529958961 0.00813878591210886 NA NA NA hsa-miR-22-3p SRXN1 -0.628561621952407 1.33755558015523e-09 1.21365129107287 7.87307293245513e-11 MirTarget -0.19245124214194 0.0305454537443667 NA NA NA hsa-miR-22-3p STK39 -0.628561621952407 1.33755558015523e-09 1.59540335392395 1.26186756425741e-09 MirTarget;miRNATAP -0.66342749234897 7.1171409036912e-08 NA NA NA hsa-miR-22-3p SYT13 -0.628561621952407 1.33755558015523e-09 -2.45567389483829 3.10650606083992e-06 MirTarget -0.502954365787738 0.0428270555044765 NA NA NA hsa-miR-22-3p TBC1D12 -0.628561621952407 1.33755558015523e-09 0.311340983993608 0.000728539477682124 miRNAWalker2_validate -0.154034952490772 0.000317713652555068 NA NA NA hsa-miR-22-3p TFRC -0.628561621952407 1.33755558015523e-09 0.937052448042543 3.46645820917872e-11 miRNAWalker2_validate;miRTarBase -0.361751793861637 5.20274841022067e-08 NA NA NA hsa-miR-22-3p TGFBR1 -0.628561621952407 1.33755558015523e-09 0.015032483953787 0.878256476667177 miRNATAP -0.104283638213843 0.0218609417498084 NA NA NA hsa-miR-22-3p TJAP1 -0.628561621952407 1.33755558015523e-09 0.700634549796933 6.17996946271343e-20 MirTarget -0.289823253765602 7.43600544103127e-16 NA NA NA hsa-miR-22-3p TLK2 -0.628561621952407 1.33755558015523e-09 0.290105039821866 3.93784569121594e-06 MirTarget -0.233599710203281 1.43456912794828e-16 NA NA NA hsa-miR-22-3p TMEM120B -0.628561621952407 1.33755558015523e-09 1.34193310296135 3.11902100235044e-43 mirMAP -0.306447369032457 5.3949001781634e-10 NA NA NA hsa-miR-22-3p TMEM164 -0.628561621952407 1.33755558015523e-09 1.2706908651988 7.63591092247221e-16 MirTarget -0.350723991375191 3.26503980181287e-06 NA NA NA hsa-miR-22-3p TMEM199 -0.628561621952407 1.33755558015523e-09 0.371337981104168 6.6560238386704e-07 MirTarget -0.108776246032125 0.00185415078954313 NA NA NA hsa-miR-22-3p TP73 -0.628561621952407 1.33755558015523e-09 3.12737351940272 1.41162077669157e-23 mirMAP -0.808179945720649 1.06012353664804e-07 NA NA NA hsa-miR-22-3p TPM3 -0.628561621952407 1.33755558015523e-09 0.578207057334502 5.14265638402526e-17 MirTarget -0.280310797944258 1.24183434814254e-18 NA NA NA hsa-miR-22-3p TRIM46 -0.628561621952407 1.33755558015523e-09 1.27101173214972 7.40127158592628e-10 MirTarget -0.560376096850725 6.34849265468879e-09 NA NA NA hsa-miR-22-3p TRNAU1AP -0.628561621952407 1.33755558015523e-09 0.547804380196421 7.78071078125267e-09 MirTarget -0.154198406729659 0.000556964977081847 NA NA NA hsa-miR-22-3p TTYH3 -0.628561621952407 1.33755558015523e-09 0.770555614902691 1.06180020960171e-06 miRNATAP -0.449152062179457 7.52680399665807e-10 NA NA NA hsa-miR-22-3p UBE2Z -0.628561621952407 1.33755558015523e-09 0.338436185365393 1.5249081267636e-06 MirTarget -0.297306453175105 2.50987471469228e-21 NA NA NA hsa-miR-22-3p UNC119B -0.628561621952407 1.33755558015523e-09 1.21392832041535 7.88210718787103e-18 MirTarget -0.517104460419317 5.92453609259131e-15 NA NA NA hsa-miR-22-3p UNK -0.628561621952407 1.33755558015523e-09 0.665013703703401 1.18077802069437e-15 MirTarget;miRNATAP -0.413905871079199 1.16512258792756e-28 NA NA NA hsa-miR-22-3p USP37 -0.628561621952407 1.33755558015523e-09 0.137344337394476 0.202332777644403 MirTarget;miRNATAP -0.425504817978153 6.28992689717609e-19 NA NA NA hsa-miR-22-3p USP46 -0.628561621952407 1.33755558015523e-09 0.37866037663651 5.0736070332912e-05 miRNATAP -0.183510700378797 2.3454351422992e-05 NA NA NA hsa-miR-22-3p UTP18 -0.628561621952407 1.33755558015523e-09 0.40400077183642 3.27185211788699e-07 MirTarget -0.345122185108093 1.17842856300083e-22 NA NA NA hsa-miR-22-3p VANGL1 -0.628561621952407 1.33755558015523e-09 0.205997711038247 0.0305684838094997 mirMAP -0.201656582804415 4.23251723606763e-06 NA NA NA hsa-miR-22-3p VASP -0.628561621952407 1.33755558015523e-09 0.192841963588359 0.0516112278985759 miRNATAP -0.28867207634921 1.48754118655431e-10 NA NA NA hsa-miR-22-3p WARS2 -0.628561621952407 1.33755558015523e-09 0.101003270315102 0.223459540455861 MirTarget -0.151732052703396 7.08181094829698e-05 NA NA NA hsa-miR-22-3p WASF1 -0.628561621952407 1.33755558015523e-09 0.439540363305626 0.00258561023132441 MirTarget;miRNATAP -0.489950002846106 1.29183217021135e-13 NA NA NA hsa-miR-22-3p WDR82 -0.628561621952407 1.33755558015523e-09 -0.158892416640045 0.0160561288781176 MirTarget -0.109291537614548 0.000325519958849084 NA NA NA hsa-miR-22-3p WNK2 -0.628561621952407 1.33755558015523e-09 -1.89518323977929 0.000316140316980393 mirMAP -1.35264179328415 2.57850462278125e-08 NA NA NA hsa-miR-22-3p WRNIP1 -0.628561621952407 1.33755558015523e-09 0.268605078101601 0.000600017595750333 MirTarget;miRNATAP -0.185649163852729 2.49633759488212e-07 NA NA NA hsa-miR-22-3p YWHAZ -0.628561621952407 1.33755558015523e-09 0.521348507448096 2.46588555709085e-06 MirTarget -0.422402725731077 3.08582185459414e-17 NA NA NA hsa-miR-22-3p ZBTB39 -0.628561621952407 1.33755558015523e-09 0.298869678409894 0.00533252508909905 MirTarget;miRNATAP -0.182712707157697 0.000238900406773672 NA NA NA hsa-miR-22-3p ZFP41 -0.628561621952407 1.33755558015523e-09 1.68571425193753 7.24184178265088e-33 mirMAP -0.493726684376451 1.07588693399063e-12 NA NA NA hsa-miR-22-3p ZMYM4 -0.628561621952407 1.33755558015523e-09 -0.00478383449665465 0.950400893979579 MirTarget -0.19214165397776 4.14623617495885e-08 NA NA NA hsa-miR-22-3p ZNF217 -0.628561621952407 1.33755558015523e-09 -0.0321039473250639 0.802117415726816 miRNAWalker2_validate -0.176917716116979 0.00286976865520189 NA NA NA hsa-miR-22-3p ZNF512B -0.628561621952407 1.33755558015523e-09 0.949756749303405 1.79541489585724e-18 MirTarget -0.253684584975156 1.06321016478719e-06 NA NA NA hsa-miR-22-3p ZNF618 -0.628561621952407 1.33755558015523e-09 0.943831859691578 2.40047580237559e-12 miRNATAP -0.462809638119124 1.32478258496147e-13 NA NA NA hsa-miR-22-3p ZNF706 -0.628561621952407 1.33755558015523e-09 0.69544900912348 1.21989293101682e-10 MirTarget -0.191185616472543 0.000182626491557512 NA NA NA