miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-200b-3p AAK1 5.56167217794639 6.43540045061709e-16 0.0308293803997834 0.92614239756046 TargetScan -0.116041517026509 5.93157488696267e-06 NA NA NA hsa-miR-200a-3p ABCA1 6.336081120041 4.024313571871e-16 0.717236918567415 0.28063880259552 mirMAP -0.222798814976636 8.75357995971121e-07 NA NA NA hsa-miR-200b-3p ABCA1 5.56167217794639 6.43540045061709e-16 0.717236918567415 0.28063880259552 TargetScan -0.270777221704894 1.23286065564275e-07 NA NA NA hsa-miR-200b-3p ABCA10 5.56167217794639 6.43540045061709e-16 -3.89113210169882 5.45221091737529e-05 mirMAP -0.154105237782307 0.0445427328532616 NA NA NA hsa-miR-200a-3p ABL2 6.336081120041 4.024313571871e-16 -0.106322319483403 0.764090712150794 MirTarget;miRNATAP -0.135377720634544 1.42262998762043e-08 NA NA NA hsa-miR-200a-5p ABL2 6.52092140839401 5.73108242597059e-22 -0.106322319483403 0.764090712150794 mirMAP -0.122264228766616 6.97349390579669e-06 NA NA NA hsa-miR-200b-3p ABL2 5.56167217794639 6.43540045061709e-16 -0.106322319483403 0.764090712150794 MirTarget -0.165743423356095 7.62877562582938e-10 NA NA NA hsa-miR-200b-5p ABL2 6.81954246537908 6.31100593281326e-24 -0.106322319483403 0.764090712150794 mirMAP -0.125857024459214 3.18257932069227e-06 NA NA NA hsa-miR-200b-3p ACTC1 5.56167217794639 6.43540045061709e-16 -6.25834225127145 4.25760506671468e-06 MirTarget -0.508681143337981 2.04432534146172e-06 NA NA NA hsa-miR-200b-3p ADAMTS12 5.56167217794639 6.43540045061709e-16 -2.62618286693355 0.0354269040230339 mirMAP -0.487783065393259 4.57194498176193e-07 NA NA NA hsa-miR-200b-3p ADAMTS3 5.56167217794639 6.43540045061709e-16 -3.48130921698636 0.00157655828861854 TargetScan -0.494013357035254 6.55280375724921e-09 NA NA NA hsa-miR-200b-3p ADAMTS5 5.56167217794639 6.43540045061709e-16 -6.22026337884656 3.49544969370274e-11 mirMAP -0.42151833277397 1.64824772041628e-08 NA NA NA hsa-miR-200a-3p ADARB1 6.336081120041 4.024313571871e-16 -2.48490001436941 1.26094162198918e-05 MirTarget -0.227819872279143 5.22547707545192e-09 NA NA NA hsa-miR-200b-3p ADCY1 5.56167217794639 6.43540045061709e-16 -1.33967537741524 0.204457679829343 mirMAP -0.212391509346242 0.010347083565287 NA NA NA hsa-miR-200b-3p ADCY9 5.56167217794639 6.43540045061709e-16 -0.650521425195073 0.182708034253541 TargetScan -0.132207211281142 0.000512401882320717 NA NA NA hsa-miR-200a-5p ADD2 6.52092140839401 5.73108242597059e-22 -0.633428226051517 0.653184884383254 mirMAP -0.312292464612957 0.00448442137714605 NA NA NA hsa-miR-200b-5p ADD2 6.81954246537908 6.31100593281326e-24 -0.633428226051517 0.653184884383254 mirMAP -0.315205557085328 0.00390908030760722 NA NA NA hsa-miR-200b-5p ADH1B 6.81954246537908 6.31100593281326e-24 -10.2588086939616 1.60335816710765e-10 mirMAP -0.505921176662478 7.41792415531449e-05 NA NA NA hsa-miR-200a-5p AFF3 6.52092140839401 5.73108242597059e-22 -4.68601926745895 6.97738857315821e-07 MirTarget -0.373372238034579 4.52404563578327e-07 NA NA NA hsa-miR-200b-3p AFF3 5.56167217794639 6.43540045061709e-16 -4.68601926745895 6.97738857315821e-07 MirTarget;TargetScan -0.276287780769012 0.000231873960519816 NA NA NA hsa-miR-200b-5p AFF3 6.81954246537908 6.31100593281326e-24 -4.68601926745895 6.97738857315821e-07 MirTarget -0.414716570947178 1.45825203457185e-08 NA NA NA hsa-miR-200a-3p AGPAT4 6.336081120041 4.024313571871e-16 -1.7798624427314 0.0317728844501966 mirMAP -0.16978551144367 0.00309177359756382 NA NA NA hsa-miR-200b-3p AHNAK 5.56167217794639 6.43540045061709e-16 -1.18541721981777 0.0309063330103585 TargetScan -0.195887633218533 4.31483003039321e-06 NA NA NA hsa-miR-200a-5p AKAP2 6.52092140839401 5.73108242597059e-22 -3.13025207576624 0.0403736812707877 mirMAP -0.478711313577183 5.45747264040433e-05 NA NA NA hsa-miR-200b-3p AKAP2 5.56167217794639 6.43540045061709e-16 -3.13025207576624 0.0403736812707877 TargetScan -0.536607567991655 6.23715875785858e-06 NA NA NA hsa-miR-200b-5p AKAP2 6.81954246537908 6.31100593281326e-24 -3.13025207576624 0.0403736812707877 mirMAP -0.539925212808261 4.32705277574214e-06 NA NA NA hsa-miR-200b-3p AMFR 5.56167217794639 6.43540045061709e-16 -0.833444794460511 0.00329989511126944 TargetScan -0.101863002327951 3.43079344373119e-06 NA NA NA hsa-miR-200b-5p AMOTL1 6.81954246537908 6.31100593281326e-24 -0.989320362301362 0.1813968290719 mirMAP -0.261675778996772 4.06978164209286e-06 NA NA NA hsa-miR-200b-3p AMOTL2 5.56167217794639 6.43540045061709e-16 -0.940829609541429 0.108108702719991 MirTarget;TargetScan -0.268968951028791 1.99229740563251e-09 NA NA NA hsa-miR-200a-3p AMZ1 6.336081120041 4.024313571871e-16 -1.49344927930066 0.102860152097912 mirMAP -0.284677007324265 5.61318823010087e-06 NA NA NA hsa-miR-200a-3p ANGPTL1 6.336081120041 4.024313571871e-16 -8.04237757918349 4.19490701254934e-10 MirTarget -0.465439572804377 2.60666557129902e-07 NA NA NA hsa-miR-200a-3p ANK2 6.336081120041 4.024313571871e-16 -5.409622416688 8.7040592161347e-07 miRNATAP -0.340047478139686 9.2895002866012e-06 NA NA NA hsa-miR-200b-3p ANKH 5.56167217794639 6.43540045061709e-16 -0.625238703332294 0.367358595931776 TargetScan -0.282589913130878 1.21682540813036e-07 NA NA NA hsa-miR-200a-3p ANO6 6.336081120041 4.024313571871e-16 -1.41782235968527 0.000168013749385316 MirTarget -0.163054969702508 1.67572873167979e-10 NA NA NA hsa-miR-200b-3p ANO6 5.56167217794639 6.43540045061709e-16 -1.41782235968527 0.000168013749385316 TargetScan -0.187894867153235 7.93926758435877e-11 NA NA NA hsa-miR-200b-3p AP1S2 5.56167217794639 6.43540045061709e-16 -2.97358822625767 7.9362568706807e-10 MirTarget;TargetScan -0.206811946743134 6.60752799291016e-08 NA NA NA hsa-miR-200a-3p APBB2 6.336081120041 4.024313571871e-16 -1.53436038486834 0.00158116861980178 MirTarget;miRNATAP -0.125376618035902 0.000187494328628486 NA NA NA hsa-miR-200b-5p APBB2 6.81954246537908 6.31100593281326e-24 -1.53436038486834 0.00158116861980178 mirMAP -0.18248217486412 1.04112806819953e-06 NA NA NA hsa-miR-200b-3p APLP2 5.56167217794639 6.43540045061709e-16 -0.811137641873811 0.0619115095174794 TargetScan -0.103938344679917 0.00220994125359145 NA NA NA hsa-miR-200a-3p AR 6.336081120041 4.024313571871e-16 -4.5730296286837 0.00169070552929284 mirMAP -0.228639190368987 0.024483393515382 24391862 We identified miR-200 b as a downstream target of androgen receptor and linked its expression to decreased tumorigenicity and metastatic capacity of the prostate cancer cells prostate cancer hsa-miR-200a-5p AR 6.52092140839401 5.73108242597059e-22 -4.5730296286837 0.00169070552929284 miRNATAP -0.286762937602073 0.0123373858595602 24391862 We identified miR-200 b as a downstream target of androgen receptor and linked its expression to decreased tumorigenicity and metastatic capacity of the prostate cancer cells prostate cancer hsa-miR-200b-3p ARHGAP20 5.56167217794639 6.43540045061709e-16 -3.55822292741935 0.00051193912705013 MirTarget;TargetScan -0.440161656708072 3.04977613731008e-08 NA NA NA hsa-miR-200b-3p ARHGAP28 5.56167217794639 6.43540045061709e-16 -2.52434334336667 0.0426301253491 MirTarget -0.272732736202502 0.00530107873163567 NA NA NA hsa-miR-200b-3p ARHGAP6 5.56167217794639 6.43540045061709e-16 -5.44836894935852 1.96802214068867e-09 MirTarget;TargetScan -0.29212484902946 5.80480423406064e-05 NA NA NA hsa-miR-200b-3p ARHGEF17 5.56167217794639 6.43540045061709e-16 -2.19274449241421 7.74983254330356e-06 TargetScan -0.143640050861694 0.000208752296030691 NA NA NA hsa-miR-200b-3p ARHGEF6 5.56167217794639 6.43540045061709e-16 -2.30803955098712 0.000335649372088745 mirMAP -0.279162459351065 2.21598292340625e-08 NA NA NA hsa-miR-200a-3p ARID5B 6.336081120041 4.024313571871e-16 -2.20899777419285 3.27504823423654e-07 miRNATAP -0.138241498161555 4.34075673117201e-06 NA NA NA hsa-miR-200b-3p ARID5B 5.56167217794639 6.43540045061709e-16 -2.20899777419285 3.27504823423654e-07 TargetScan -0.167814404491517 8.10660401204682e-07 NA NA NA hsa-miR-200a-3p ARL10 6.336081120041 4.024313571871e-16 -0.752217820421508 0.352817357063532 mirMAP -0.268331613865387 1.17368908072545e-06 NA NA NA hsa-miR-200b-3p ARL10 5.56167217794639 6.43540045061709e-16 -0.752217820421508 0.352817357063532 mirMAP -0.300290278869881 1.62231343234567e-06 NA NA NA hsa-miR-200b-3p ARL15 5.56167217794639 6.43540045061709e-16 -0.849758331016717 0.149470768011084 MirTarget -0.123508650140807 0.00749606939501276 NA NA NA hsa-miR-200b-3p ARL2BP 5.56167217794639 6.43540045061709e-16 -0.966372887595977 0.00153581275849949 TargetScan -0.148032145137483 2.08659851135333e-10 NA NA NA hsa-miR-200b-3p ASAP1 5.56167217794639 6.43540045061709e-16 -0.151385521914876 0.714275215082014 MirTarget;TargetScan -0.158845723939936 5.9638901838219e-07 NA NA NA hsa-miR-200b-3p ATMIN 5.56167217794639 6.43540045061709e-16 0.137627910922637 0.612661515217601 TargetScan -0.104427216238218 5.17657604736423e-07 NA NA NA hsa-miR-200b-3p ATP11C 5.56167217794639 6.43540045061709e-16 -0.873029093406436 0.0904671829482675 MirTarget;TargetScan -0.112932978120583 0.00516497016221896 NA NA NA hsa-miR-200a-5p ATP8B4 6.52092140839401 5.73108242597059e-22 -2.31455469851729 0.000341991946275883 MirTarget -0.353916182936748 5.50092392337848e-13 NA NA NA hsa-miR-200b-5p ATP8B4 6.81954246537908 6.31100593281326e-24 -2.31455469851729 0.000341991946275883 MirTarget -0.366491104576248 4.6962875762215e-14 NA NA NA hsa-miR-200a-3p BACH2 6.336081120041 4.024313571871e-16 -2.72766253823841 0.00174098676396876 mirMAP -0.215720137730898 0.000352985925189175 NA NA NA hsa-miR-200b-3p BACH2 5.56167217794639 6.43540045061709e-16 -2.72766253823841 0.00174098676396876 TargetScan;mirMAP -0.198467446772618 0.00385902698805819 NA NA NA hsa-miR-200b-3p BASP1 5.56167217794639 6.43540045061709e-16 -1.12470485256406 0.329085541806455 TargetScan -0.72674548391977 2.44718206752463e-17 NA NA NA hsa-miR-200b-5p BCAT1 6.81954246537908 6.31100593281326e-24 -1.60203772641162 0.1371486739857 mirMAP -0.235936546650219 0.00479857391301133 NA NA NA hsa-miR-200b-3p BCL11B 5.56167217794639 6.43540045061709e-16 2.87244846908751 0.00736945807768579 TargetScan -0.220861938990297 0.00893199060796436 NA NA NA hsa-miR-200a-5p BCL2 6.52092140839401 5.73108242597059e-22 -3.06316187948847 1.08810932834372e-05 mirMAP -0.195494336988318 0.000366255804733623 NA NA NA hsa-miR-200b-3p BCL2 5.56167217794639 6.43540045061709e-16 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase;TargetScan;mirMAP -0.114344876372448 0.0393261839456269 NA NA NA hsa-miR-200b-5p BCL2 6.81954246537908 6.31100593281326e-24 -3.06316187948847 1.08810932834372e-05 mirMAP -0.203388603979853 0.000189900674957038 NA NA NA hsa-miR-200b-3p BICC1 5.56167217794639 6.43540045061709e-16 -2.18964659589932 0.0974661339564291 TargetScan -0.471342115746073 4.32271075426518e-06 NA NA NA hsa-miR-200a-3p BICD2 6.336081120041 4.024313571871e-16 0.8634095483664 0.214130449097462 MirTarget;miRNATAP -0.236553191316868 5.87722643314997e-07 NA NA NA hsa-miR-200b-3p BICD2 5.56167217794639 6.43540045061709e-16 0.8634095483664 0.214130449097462 TargetScan -0.257978564585379 1.60069424341138e-06 NA NA NA hsa-miR-200b-3p BLCAP 5.56167217794639 6.43540045061709e-16 0.833312694739009 0.0487466593127844 MirTarget -0.114546961032171 0.000514847365256227 NA NA NA hsa-miR-200b-3p BNC2 5.56167217794639 6.43540045061709e-16 -6.04221863045668 1.28592064404143e-10 MirTarget;TargetScan -0.485647467624096 5.00362677390431e-11 NA NA NA hsa-miR-200b-3p BNIP2 5.56167217794639 6.43540045061709e-16 -0.408589187448363 0.188810503420601 mirMAP -0.111277310745194 3.36815971857045e-06 NA NA NA hsa-miR-200b-3p C11orf87 5.56167217794639 6.43540045061709e-16 -3.96353102190994 0.00130676712385478 TargetScan -0.329660697143535 0.000682196977560479 NA NA NA hsa-miR-200b-3p C17orf51 5.56167217794639 6.43540045061709e-16 -1.61262787783029 0.0604777801181298 mirMAP -0.244305318883402 0.000272803195875898 NA NA NA hsa-miR-200a-3p C1orf21 6.336081120041 4.024313571871e-16 -1.27104982677537 0.0681023123830772 miRNATAP -0.193184460891224 5.45606745772509e-05 NA NA NA hsa-miR-200a-3p C20orf194 6.336081120041 4.024313571871e-16 -1.85765214143259 0.000500533610416263 mirMAP -0.106655886517569 0.00408433400276879 NA NA NA hsa-miR-200b-3p C4orf32 5.56167217794639 6.43540045061709e-16 -1.52353576411351 0.00665546699552738 TargetScan -0.196346176954207 7.03730666112455e-06 NA NA NA hsa-miR-200b-3p CAB39 5.56167217794639 6.43540045061709e-16 -0.0409146299829386 0.906829073267508 MirTarget;TargetScan -0.100352999717768 0.000212774430958134 NA NA NA hsa-miR-200b-3p CACNA1C 5.56167217794639 6.43540045061709e-16 -5.47617607166292 9.14588480929742e-11 MirTarget;TargetScan -0.333728594581851 7.59065015614495e-07 NA NA NA hsa-miR-200b-3p CACNA2D1 5.56167217794639 6.43540045061709e-16 -0.900900006170782 0.611649328760661 TargetScan -0.311379327815264 0.0254031919531762 NA NA NA hsa-miR-200b-3p CALU 5.56167217794639 6.43540045061709e-16 -0.8475888565283 0.0346041694359576 MirTarget;TargetScan -0.160157030514789 2.22523756566954e-07 NA NA NA hsa-miR-200a-3p CAMK4 6.336081120041 4.024313571871e-16 0.834829388674018 0.395195460931575 mirMAP -0.266959950289057 7.48272596335679e-05 NA NA NA hsa-miR-200a-5p CAMK4 6.52092140839401 5.73108242597059e-22 0.834829388674018 0.395195460931575 mirMAP -0.23076474703218 0.00255041283118814 NA NA NA hsa-miR-200b-5p CAMK4 6.81954246537908 6.31100593281326e-24 0.834829388674018 0.395195460931575 mirMAP -0.209136278786359 0.00602064893578315 NA NA NA hsa-miR-200a-3p CCDC80 6.336081120041 4.024313571871e-16 -4.57675300203706 3.67250131936476e-06 MirTarget -0.388679442480801 1.13848950674998e-08 NA NA NA hsa-miR-200a-5p CCDC88A 6.52092140839401 5.73108242597059e-22 -0.174272604937737 0.770161941533445 miRNATAP -0.133835031638475 0.00393005454941743 NA NA NA hsa-miR-200a-3p CCND2 6.336081120041 4.024313571871e-16 -2.81051675901102 0.00139983736368543 MirTarget -0.414829241668513 2.52639559759353e-12 NA NA NA hsa-miR-200b-3p CCNJL 5.56167217794639 6.43540045061709e-16 1.43669768692292 0.221122846726442 TargetScan -0.346034069431027 0.000157248556719625 NA NA NA hsa-miR-200a-3p CD274 6.336081120041 4.024313571871e-16 2.22279412449515 0.0516111370736547 MirTarget -0.349325798251526 8.24128678574652e-06 NA NA NA hsa-miR-200a-3p CD59 6.336081120041 4.024313571871e-16 -0.948855962921169 0.0673706689936725 mirMAP -0.177039416341925 5.50454474949655e-07 NA NA NA hsa-miR-200a-3p CDC42EP3 6.336081120041 4.024313571871e-16 -2.44422486996004 0.000461081013553153 MirTarget -0.241424189238553 4.78151406383186e-07 NA NA NA hsa-miR-200b-3p CDC42EP3 5.56167217794639 6.43540045061709e-16 -2.44422486996004 0.000461081013553153 TargetScan -0.27327736572211 4.97490525035949e-07 NA NA NA hsa-miR-200b-3p CDH11 5.56167217794639 6.43540045061709e-16 -2.71859034741409 0.00843049688225146 TargetScan -0.36980388813511 4.19309498405349e-06 NA NA NA hsa-miR-200a-3p CDK17 6.336081120041 4.024313571871e-16 -1.12328504410322 0.000900632997943985 MirTarget;miRNATAP -0.155394219003866 8.05618644749653e-12 NA NA NA hsa-miR-200b-3p CDK17 5.56167217794639 6.43540045061709e-16 -1.12328504410322 0.000900632997943985 MirTarget;TargetScan -0.185067542130194 5.43958016383902e-13 NA NA NA hsa-miR-200a-3p CDK6 6.336081120041 4.024313571871e-16 0.50406574702617 0.551236779554206 miRNATAP -0.351978863285198 6.61784093516688e-10 24009066 microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6 liver cancer hsa-miR-200b-3p CDK6 5.56167217794639 6.43540045061709e-16 0.50406574702617 0.551236779554206 mirMAP -0.393674008810918 1.1478210539551e-09 NA NA NA hsa-miR-200b-3p CDYL2 5.56167217794639 6.43540045061709e-16 1.43419602835799 0.13708256115421 TargetScan -0.30039180749528 6.39700600648687e-05 NA NA NA hsa-miR-200b-3p CEBPD 5.56167217794639 6.43540045061709e-16 -0.710510624184712 0.264056437039447 TargetScan -0.119324456029841 0.0167494565723608 NA NA NA hsa-miR-200b-3p CECR2 5.56167217794639 6.43540045061709e-16 -0.435546866621632 0.807223196888443 TargetScan -0.362234506135273 0.00962833829135818 NA NA NA hsa-miR-200a-3p CECR6 6.336081120041 4.024313571871e-16 -0.0854648054596273 0.898236796266066 mirMAP -0.111210199746479 0.0160369638520709 NA NA NA hsa-miR-200a-3p CELF2 6.336081120041 4.024313571871e-16 -2.48163199573256 0.00126436670635573 mirMAP -0.233273174639178 1.10897470463207e-05 NA NA NA hsa-miR-200b-3p CELF2 5.56167217794639 6.43540045061709e-16 -2.48163199573256 0.00126436670635573 TargetScan;mirMAP -0.262129658127748 1.32918075466963e-05 NA NA NA hsa-miR-200b-3p CFL2 5.56167217794639 6.43540045061709e-16 -3.32978432910491 1.5605491931502e-10 MirTarget;TargetScan -0.189741509753949 5.02645702488381e-06 NA NA NA hsa-miR-200a-3p CHRDL1 6.336081120041 4.024313571871e-16 -10.0047369671436 6.00614874866061e-09 MirTarget -0.590626368784503 9.53154748186544e-07 NA NA NA hsa-miR-200b-3p CHRDL1 5.56167217794639 6.43540045061709e-16 -10.0047369671436 6.00614874866061e-09 MirTarget;TargetScan -0.603281275495641 1.08453315250154e-05 NA NA NA hsa-miR-200b-3p CHST11 5.56167217794639 6.43540045061709e-16 0.00939719081667834 0.990919854205087 mirMAP -0.477784428390983 1.29480856701525e-14 NA NA NA hsa-miR-200b-3p CHST2 5.56167217794639 6.43540045061709e-16 -0.561153608977267 0.584518016033006 TargetScan -0.422924748793498 8.66748298111413e-08 NA NA NA hsa-miR-200b-3p CHSY1 5.56167217794639 6.43540045061709e-16 -0.93837078496993 0.0222476379044818 TargetScan -0.172731336134471 4.54561965007973e-08 NA NA NA hsa-miR-200b-3p CHSY3 5.56167217794639 6.43540045061709e-16 -1.19902064286194 0.186669920116192 TargetScan -0.297995110079159 2.4273800963153e-05 NA NA NA hsa-miR-200b-3p CITED2 5.56167217794639 6.43540045061709e-16 -2.81556973832692 4.67183448218434e-07 TargetScan -0.173574050374759 8.92871385489632e-05 NA NA NA hsa-miR-200a-3p CLIC4 6.336081120041 4.024313571871e-16 -2.06990721699453 5.50896805060539e-06 MirTarget -0.215264613853335 3.09638406756447e-12 NA NA NA hsa-miR-200b-3p CLIC4 5.56167217794639 6.43540045061709e-16 -2.06990721699453 5.50896805060539e-06 MirTarget;TargetScan -0.238451924615947 1.03639079256851e-11 NA NA NA hsa-miR-200b-3p CLIP1 5.56167217794639 6.43540045061709e-16 0.26298689144361 0.566256701194068 TargetScan -0.168235943373685 1.9835982130843e-06 NA NA NA hsa-miR-200b-3p CNN3 5.56167217794639 6.43540045061709e-16 -1.93238478845593 5.87025127112623e-05 MirTarget;TargetScan -0.135243148162964 0.000359522397505832 NA NA NA hsa-miR-200b-3p CNTFR 5.56167217794639 6.43540045061709e-16 -4.16050425920299 0.0242985747340731 TargetScan -0.444568741426208 0.00218000027745392 NA NA NA hsa-miR-200a-3p CNTN1 6.336081120041 4.024313571871e-16 -2.8506240179562 0.128333090411541 MirTarget;miRNATAP -0.288321156422678 0.0266269338497402 NA NA NA hsa-miR-200a-3p COL11A1 6.336081120041 4.024313571871e-16 -0.788855321813521 0.686347859403413 miRNATAP -0.473021719168829 0.000435832454801496 NA NA NA hsa-miR-200a-3p COL15A1 6.336081120041 4.024313571871e-16 -2.41855782003795 0.00253445946731209 MirTarget -0.262431231461974 1.85625201414874e-06 NA NA NA hsa-miR-200b-3p COL4A3 5.56167217794639 6.43540045061709e-16 -0.962457819759664 0.474906169860219 TargetScan -0.224349604196211 0.033961768955459 NA NA NA hsa-miR-200a-3p COL8A1 6.336081120041 4.024313571871e-16 -0.105319430224367 0.927732333702246 mirMAP -0.310028922651861 0.000100762221515205 NA NA NA hsa-miR-200b-3p CORO1C 5.56167217794639 6.43540045061709e-16 -0.827005048788016 0.0204817960853398 MirTarget;TargetScan -0.141581178392918 2.64145340269614e-07 NA NA NA hsa-miR-200a-5p CRIM1 6.52092140839401 5.73108242597059e-22 -1.63005350893296 0.0198190879496112 MirTarget -0.256475648885114 2.11073387789484e-06 NA NA NA hsa-miR-200b-5p CRIM1 6.81954246537908 6.31100593281326e-24 -1.63005350893296 0.0198190879496112 MirTarget -0.227510696703681 2.4990974405526e-05 NA NA NA hsa-miR-200a-3p CRMP1 6.336081120041 4.024313571871e-16 -2.47914008999701 0.0245711512602417 MirTarget -0.239599524519312 0.00169878573985948 NA NA NA hsa-miR-200b-3p CRTAP 5.56167217794639 6.43540045061709e-16 -1.98821541128519 1.08501885909156e-09 TargetScan -0.185940519679289 1.58950772458454e-13 NA NA NA hsa-miR-200a-3p CSTA 6.336081120041 4.024313571871e-16 6.57128084598624 0.000783509990875802 MirTarget -0.493143545111116 0.000282463055383385 NA NA NA hsa-miR-200a-3p CTSC 6.336081120041 4.024313571871e-16 1.5050068604346 0.0131586595956066 mirMAP -0.108088901330785 0.0102741076329263 NA NA NA hsa-miR-200a-5p CUX1 6.52092140839401 5.73108242597059e-22 -1.30440541679249 0.0010804147177738 mirMAP -0.123745793762244 6.74543708991214e-05 NA NA NA hsa-miR-200b-5p CUX1 6.81954246537908 6.31100593281326e-24 -1.30440541679249 0.0010804147177738 mirMAP -0.1157183437461 0.000182416737001058 NA NA NA hsa-miR-200a-5p CWH43 6.52092140839401 5.73108242597059e-22 4.53100245718744 0.0739425855194126 MirTarget -0.405247048615232 0.0415188793240015 NA NA NA hsa-miR-200a-3p CXCL12 6.336081120041 4.024313571871e-16 -5.99088601475679 5.43950830992156e-09 miRNATAP -0.450261578521708 2.28833051106536e-10 NA NA NA hsa-miR-200b-5p CYLD 6.81954246537908 6.31100593281326e-24 -0.0454280711536628 0.90145225801027 mirMAP -0.125419857618317 7.61675376875037e-06 NA NA NA hsa-miR-200b-3p CYP1B1 5.56167217794639 6.43540045061709e-16 -3.72962588132672 0.00103598214547263 TargetScan -0.327448142212037 0.000248548231178954 NA NA NA hsa-miR-200a-3p CYP26B1 6.336081120041 4.024313571871e-16 1.58563908330085 0.0886003975315947 MirTarget;miRNATAP -0.299011331046574 2.68542576069435e-06 NA NA NA hsa-miR-200b-3p CYTH3 5.56167217794639 6.43540045061709e-16 -1.4549734725687 0.00123477304703255 MirTarget;TargetScan -0.153083642012378 1.31972088853344e-05 NA NA NA hsa-miR-200b-3p DACT1 5.56167217794639 6.43540045061709e-16 -3.3724949271607 0.00113281420676785 TargetScan -0.316487355392311 9.93054553252835e-05 NA NA NA hsa-miR-200b-3p DCUN1D3 5.56167217794639 6.43540045061709e-16 -0.848813611238834 0.0236585928026107 TargetScan -0.113788947410819 9.67963272043701e-05 NA NA NA hsa-miR-200b-3p DDIT4 5.56167217794639 6.43540045061709e-16 0.477804731551061 0.499952560954147 TargetScan -0.146171543167626 0.00840500015299485 NA NA NA hsa-miR-200b-3p DENND2C 5.56167217794639 6.43540045061709e-16 1.53782928713607 0.235359868563845 TargetScan -0.324807576554825 0.00135628835075995 NA NA NA hsa-miR-200b-3p DENND5B 5.56167217794639 6.43540045061709e-16 -2.36002112820187 0.00535049629913005 MirTarget;TargetScan;mirMAP -0.268889148303464 4.94980144569333e-05 NA NA NA hsa-miR-200b-3p DIXDC1 5.56167217794639 6.43540045061709e-16 -4.24415941146719 1.24306330392779e-10 MirTarget;TargetScan -0.190571236777899 0.000333351960627522 NA NA NA hsa-miR-200a-3p DLC1 6.336081120041 4.024313571871e-16 -3.66271297046991 8.65727517947362e-07 miRNATAP -0.244287242535909 2.38725289991789e-06 NA NA NA hsa-miR-200a-5p DLC1 6.52092140839401 5.73108242597059e-22 -3.66271297046991 8.65727517947362e-07 miRNATAP -0.325866304688684 1.93280582118098e-08 NA NA NA hsa-miR-200b-3p DLC1 5.56167217794639 6.43540045061709e-16 -3.66271297046991 8.65727517947362e-07 TargetScan -0.275089816746344 2.79662534020967e-06 NA NA NA hsa-miR-200b-5p DLK2 6.81954246537908 6.31100593281326e-24 1.88009517691768 0.200712891731745 MirTarget -0.233330329425577 0.0413714083060887 NA NA NA hsa-miR-200b-3p DMD 5.56167217794639 6.43540045061709e-16 -4.17977171479125 0.00037283808625733 TargetScan -0.462839508781524 4.32919556036282e-07 NA NA NA hsa-miR-200a-3p DMWD 6.336081120041 4.024313571871e-16 -0.633465435862458 0.0453064225474753 MirTarget;miRNATAP -0.101143802765566 2.64988994489972e-06 NA NA NA hsa-miR-200b-3p DNAJB5 5.56167217794639 6.43540045061709e-16 -2.36670959981668 0.000173814687305954 TargetScan -0.346493760589062 6.04963601541132e-13 NA NA NA hsa-miR-200b-3p DNAJC18 5.56167217794639 6.43540045061709e-16 -2.48308218814331 3.6255265099985e-07 TargetScan -0.158765774991141 3.97799961818411e-05 NA NA NA hsa-miR-200b-3p DNM3 5.56167217794639 6.43540045061709e-16 -2.56888304303728 0.000564648070252874 mirMAP -0.144006566629646 0.0145500751041217 NA NA NA hsa-miR-200a-3p DOCK4 6.336081120041 4.024313571871e-16 -2.11104257159399 0.00042966140172098 MirTarget -0.291575333917208 4.64533242880462e-13 NA NA NA hsa-miR-200b-3p DOCK4 5.56167217794639 6.43540045061709e-16 -2.11104257159399 0.00042966140172098 MirTarget;TargetScan -0.327451912173822 7.94791250063228e-13 NA NA NA hsa-miR-200b-3p DRP2 5.56167217794639 6.43540045061709e-16 -1.91240250758769 0.00657941206731193 mirMAP -0.177940864753479 0.00128277418847833 NA NA NA hsa-miR-200a-3p DST 6.336081120041 4.024313571871e-16 -1.13168714065604 0.251054297059684 mirMAP -0.318424842912785 2.27440240990563e-06 NA NA NA hsa-miR-200b-3p DST 5.56167217794639 6.43540045061709e-16 -1.13168714065604 0.251054297059684 mirMAP -0.398086894413212 1.65100329272265e-07 NA NA NA hsa-miR-200b-3p DUSP1 5.56167217794639 6.43540045061709e-16 -2.32150271759423 0.0116270325712639 MirTarget;TargetScan -0.27097800404229 0.000167798828015549 NA NA NA hsa-miR-200b-3p DUSP7 5.56167217794639 6.43540045061709e-16 0.941325036101027 0.222553851723417 TargetScan -0.275840517529102 3.96982637898899e-06 NA NA NA hsa-miR-200a-3p DYNC1I1 6.336081120041 4.024313571871e-16 -2.7683005768424 0.0629318850142809 MirTarget -0.235764133855364 0.0225181703960342 NA NA NA hsa-miR-200a-3p DZIP1 6.336081120041 4.024313571871e-16 -2.74309374194839 0.00323493660512733 miRNATAP -0.25772629486985 6.19141259747435e-05 NA NA NA hsa-miR-200a-5p DZIP1 6.52092140839401 5.73108242597059e-22 -2.74309374194839 0.00323493660512733 mirMAP -0.295214461215455 4.76280005751676e-05 NA NA NA hsa-miR-200b-3p DZIP1 5.56167217794639 6.43540045061709e-16 -2.74309374194839 0.00323493660512733 MirTarget;TargetScan -0.300531172700847 3.73238633591066e-05 NA NA NA hsa-miR-200b-5p DZIP1 6.81954246537908 6.31100593281326e-24 -2.74309374194839 0.00323493660512733 mirMAP -0.293178977512467 4.86764563224988e-05 NA NA NA hsa-miR-200b-3p EFNB2 5.56167217794639 6.43540045061709e-16 -0.105990018975263 0.886009768077325 TargetScan -0.138476884530124 0.0168486168029486 NA NA NA hsa-miR-200a-3p EGFR 6.336081120041 4.024313571871e-16 1.4001245301835 0.170261817468909 MirTarget -0.314197934364205 6.96888933660157e-06 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-200a-3p EGR2 6.336081120041 4.024313571871e-16 -1.38884404958121 0.0932343699878996 miRNATAP -0.188681775168339 0.000952074192494844 NA NA NA hsa-miR-200b-3p EGR3 5.56167217794639 6.43540045061709e-16 -2.04215908845949 0.0326870584630155 TargetScan -0.155162763485508 0.0394231612630248 NA NA NA hsa-miR-200a-3p EHD3 6.336081120041 4.024313571871e-16 -0.453694277174124 0.54454583408973 mirMAP -0.204049029135035 7.08952517825326e-05 NA NA NA hsa-miR-200b-5p EID1 6.81954246537908 6.31100593281326e-24 -2.0956147982004 2.56042877916745e-09 MirTarget -0.100468202036187 0.000301033491195939 NA NA NA hsa-miR-200b-3p EIF4E3 5.56167217794639 6.43540045061709e-16 -1.54866320321324 0.00186416459175042 TargetScan -0.107669467234666 0.00601907388940974 NA NA NA hsa-miR-200a-3p ELAVL2 6.336081120041 4.024313571871e-16 1.95321662505849 0.322716473884614 MirTarget;miRNATAP -0.285876180895701 0.0368491721861492 NA NA NA hsa-miR-200b-3p ELAVL2 5.56167217794639 6.43540045061709e-16 1.95321662505849 0.322716473884614 MirTarget;TargetScan -0.319177296286641 0.0398078897688718 NA NA NA hsa-miR-200b-3p ELK3 5.56167217794639 6.43540045061709e-16 -0.79092498872197 0.293399668627417 TargetScan -0.349584516026115 1.26994687967733e-09 NA NA NA hsa-miR-200b-3p ELL 5.56167217794639 6.43540045061709e-16 -0.517514537527021 0.0550682204855227 TargetScan -0.10810738116761 1.68092159399688e-07 NA NA NA hsa-miR-200b-3p ELL2 5.56167217794639 6.43540045061709e-16 1.14898878375218 0.0653318452036143 MirTarget;TargetScan -0.183079297196573 0.000166752677037755 NA NA NA hsa-miR-200b-3p EMB 5.56167217794639 6.43540045061709e-16 1.23268382721111 0.177257665709977 TargetScan -0.209197179815667 0.00346568982044484 NA NA NA hsa-miR-200b-3p ENDOD1 5.56167217794639 6.43540045061709e-16 -1.15080298333206 0.0185661445984158 TargetScan -0.126814654390186 0.000916290413422611 NA NA NA hsa-miR-200b-3p ENPEP 5.56167217794639 6.43540045061709e-16 -4.20336312367053 7.41825576929555e-06 mirMAP -0.524282851490938 3.17814565961097e-13 NA NA NA hsa-miR-200a-5p ENTPD1 6.52092140839401 5.73108242597059e-22 -1.65448165389233 4.89293666031054e-07 mirMAP -0.18775188647177 6.23522796760655e-14 NA NA NA hsa-miR-200b-3p ENTPD1 5.56167217794639 6.43540045061709e-16 -1.65448165389233 4.89293666031054e-07 MirTarget;mirMAP -0.161292993839443 2.36850700057944e-10 NA NA NA hsa-miR-200b-5p ENTPD1 6.81954246537908 6.31100593281326e-24 -1.65448165389233 4.89293666031054e-07 mirMAP -0.1874954875036 4.74100313279366e-14 NA NA NA hsa-miR-200a-3p EPB41L3 6.336081120041 4.024313571871e-16 -2.44624908679027 0.00114996440677623 miRNATAP -0.179693198285595 0.000577497678651402 NA NA NA hsa-miR-200b-3p ERC1 5.56167217794639 6.43540045061709e-16 -0.277646801807955 0.492350568699496 TargetScan;mirMAP -0.104036253524877 0.000948468348166198 NA NA NA hsa-miR-200a-3p ERC2 6.336081120041 4.024313571871e-16 0.365155202927402 0.73571492660221 MirTarget -0.149923978643453 0.0454635093792565 NA NA NA hsa-miR-200a-3p ERG 6.336081120041 4.024313571871e-16 -2.93230429825036 4.79380753292208e-05 MirTarget -0.35826140468437 1.67628063950123e-13 NA NA NA hsa-miR-200b-3p ERG 5.56167217794639 6.43540045061709e-16 -2.93230429825036 4.79380753292208e-05 TargetScan -0.426090676911592 7.72407996527289e-15 27191272 The tumor suppressive miR 200b subfamily is an ERG target gene in human prostate tumors; Although induction of the tumor suppressive miR-200b subfamily by oncogenic ERG appears to be counterintuitive it is consistent with the observation that the vast majority of primary prostate cancers are slow-growing and indolent prostate cancer hsa-miR-200b-3p ERRFI1 5.56167217794639 6.43540045061709e-16 -0.915252993110758 0.206921921321491 MirTarget;TargetScan -0.164220582453955 0.00382404511258688 NA NA NA hsa-miR-200a-3p ETS1 6.336081120041 4.024313571871e-16 -1.32722784146339 0.0272778960906174 mirMAP -0.217123772669127 1.14672241771271e-07 NA NA NA hsa-miR-200b-3p ETS1 5.56167217794639 6.43540045061709e-16 -1.32722784146339 0.0272778960906174 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.248860269782612 8.16256844479384e-08 NA NA NA hsa-miR-200b-3p ETS2 5.56167217794639 6.43540045061709e-16 -0.136442724424438 0.846825568373063 TargetScan -0.206384302534403 0.000173763764448926 NA NA NA hsa-miR-200b-3p EXOC6B 5.56167217794639 6.43540045061709e-16 0.938515046767632 0.301747671992673 TargetScan -0.271008101526995 0.000129149767731705 NA NA NA hsa-miR-200b-3p EXT1 5.56167217794639 6.43540045061709e-16 0.9375806703726 0.0482967552601257 mirMAP -0.148332618284263 5.94357645414342e-05 NA NA NA hsa-miR-200b-3p F2RL2 5.56167217794639 6.43540045061709e-16 -2.18711919599124 0.0285972764744953 MirTarget -0.263293896157135 0.000770910194365075 NA NA NA hsa-miR-200b-3p FAM126A 5.56167217794639 6.43540045061709e-16 -0.495929140913689 0.575309467821514 TargetScan -0.52185640844958 3.72390833627698e-15 NA NA NA hsa-miR-200a-3p FAM150B 6.336081120041 4.024313571871e-16 -5.71872397314061 3.6243728723762e-05 MirTarget -0.199287224178807 0.0404462642531019 NA NA NA hsa-miR-200a-3p FAM20C 6.336081120041 4.024313571871e-16 -0.242134797907118 0.695628446814681 MirTarget -0.116661244929751 0.0063012778546737 NA NA NA hsa-miR-200a-3p FAM26E 6.336081120041 4.024313571871e-16 -3.14170309093076 0.000144302221813533 mirMAP -0.327119875284481 7.26580265553855e-09 NA NA NA hsa-miR-200a-5p FAM26E 6.52092140839401 5.73108242597059e-22 -3.14170309093076 0.000144302221813533 mirMAP -0.414734050419666 5.84966786761317e-11 NA NA NA hsa-miR-200b-3p FAM26E 5.56167217794639 6.43540045061709e-16 -3.14170309093076 0.000144302221813533 mirMAP -0.364769087239146 1.30721655711824e-08 NA NA NA hsa-miR-200b-5p FAM26E 6.81954246537908 6.31100593281326e-24 -3.14170309093076 0.000144302221813533 mirMAP -0.410028656508996 7.63830883011889e-11 NA NA NA hsa-miR-200a-3p FAT3 6.336081120041 4.024313571871e-16 -3.48327918457969 0.015252000190887 MirTarget;miRNATAP -0.227321217430503 0.0228141063968571 NA NA NA hsa-miR-200b-3p FAT3 5.56167217794639 6.43540045061709e-16 -3.48327918457969 0.015252000190887 MirTarget;TargetScan -0.247169384989071 0.0290450137476328 NA NA NA hsa-miR-200a-5p FBXO32 6.52092140839401 5.73108242597059e-22 -2.22182498753927 0.000569819198198377 mirMAP -0.262368581282422 1.44188284706103e-07 NA NA NA hsa-miR-200b-5p FBXO32 6.81954246537908 6.31100593281326e-24 -2.22182498753927 0.000569819198198377 mirMAP -0.252716507885098 3.61808910180207e-07 NA NA NA hsa-miR-200a-3p FER 6.336081120041 4.024313571871e-16 -0.196683571848675 0.752194190007424 mirMAP -0.189238557112155 8.71481733335634e-06 NA NA NA hsa-miR-200b-3p FERMT2 5.56167217794639 6.43540045061709e-16 -4.36546024261243 6.75771952930767e-07 TargetScan -0.308621624004216 8.90176865874781e-06 23483548;24064224;26334393 Here we report that Kindlin 2 markedly downregulates the expression of miR-200 family by inducing CpG island hypermethylation; Our data indicate that Kindlin 2 plays a novel role in epigenetic repression of miR-200 family a mechanism that promotes breast cancer invasion;miR 200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin 2; Quantitative mass spectrometry identified 57 putative miR-200b targets including Kindlin-2 previously implicated in the regulation of tumor invasiveness and actin cytoskeleton in other cell types; Enforced expression of miR-200b mimic in ESCC cells led to a decrease of Kindlin-2 expression whereas transfection of miR-200b inhibitor induced Kindlin-2 expression; Furthermore transfection of miR-200b mimic or knockdown of Kindlin-2 in ESCC cells decreased cell protrusion and focal adhesion FA formation reduced cell spreading and invasiveness/migration; Enforced expression of Kindlin-2 largely abrogated the inhibitory effects of miR-200b on ESCC cell invasiveness; The tumor suppressor effects of miR-200b may be due to its suppression of Kindlin-2 a novel target of miR-200b that modulates actin cytoskeleton FA formation and the migratory/invasiveness properties of ESCC;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ;; breast cancer;esophageal cancer;esophageal cancer hsa-miR-200b-3p FEZ2 5.56167217794639 6.43540045061709e-16 -1.33349435735048 1.39935793764607e-05 TargetScan -0.102253406367387 2.10319634569039e-05 NA NA NA hsa-miR-200b-5p FGF13 6.81954246537908 6.31100593281326e-24 -4.85110267282668 1.82792041988563e-05 MirTarget -0.234643072355969 0.00846026232590831 NA NA NA hsa-miR-200b-3p FGF2 5.56167217794639 6.43540045061709e-16 -4.7426237294682 2.88390048531716e-06 mirMAP -0.509650803431375 8.73024781893149e-11 NA NA NA hsa-miR-200a-5p FGFR1 6.52092140839401 5.73108242597059e-22 -3.68099244503292 0.000117634214619712 mirMAP -0.150179088472811 0.047037593758987 NA NA NA hsa-miR-200b-5p FGFR1 6.81954246537908 6.31100593281326e-24 -3.68099244503292 0.000117634214619712 mirMAP -0.204584689815958 0.00635940451614134 NA NA NA hsa-miR-200b-3p FHL1 5.56167217794639 6.43540045061709e-16 -6.4702196823406 5.09476327521356e-10 MirTarget -0.553882941346807 1.0705943981045e-11 NA NA NA hsa-miR-200b-3p FHOD1 5.56167217794639 6.43540045061709e-16 0.191338107998207 0.637355409530781 TargetScan -0.178788952946971 8.26436482377866e-09 NA NA NA hsa-miR-200b-3p FIGN 5.56167217794639 6.43540045061709e-16 -1.25444626415653 0.404563379805933 MirTarget;TargetScan -0.510516362104784 1.24781576457081e-05 NA NA NA hsa-miR-200b-3p FKBP14 5.56167217794639 6.43540045061709e-16 -0.600195826396854 0.258866513302457 mirMAP -0.151484064506175 0.000252503259437073 NA NA NA hsa-miR-200b-5p FKBP5 6.81954246537908 6.31100593281326e-24 -0.596310359911071 0.315592165482338 mirMAP -0.167085513601933 0.000265554187759599 NA NA NA hsa-miR-200b-3p FLI1 5.56167217794639 6.43540045061709e-16 -2.51391469228041 0.000170810053582531 MirTarget;TargetScan -0.435555382449731 3.67620209450992e-18 NA NA NA hsa-miR-200b-3p FLT1 5.56167217794639 6.43540045061709e-16 -2.50880932627343 2.11545598083473e-05 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.232867547380079 4.4840692649334e-07 21115742 Forced miR-200 expression suppressed Flt1 levels in metastasis-prone lung adenocarcinoma cells derived from K-ras/p53-mutant mice and negatively regulated the Flt1 3'-UTR in reporter assays; We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1 metastasis;tumorigenesis lung cancer hsa-miR-200a-5p FLVCR2 6.52092140839401 5.73108242597059e-22 0.652237405019244 0.389221140924998 MirTarget -0.201353924800808 0.000623015604247078 NA NA NA hsa-miR-200b-5p FLVCR2 6.81954246537908 6.31100593281326e-24 0.652237405019244 0.389221140924998 MirTarget -0.17761654316933 0.00245297656492416 NA NA NA hsa-miR-200b-3p FN1 5.56167217794639 6.43540045061709e-16 -1.36144636221369 0.250505962748653 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.638482901225541 1.10651140093297e-12 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-200a-5p FOXC1 6.52092140839401 5.73108242597059e-22 -0.342853111292963 0.692011983834499 miRNATAP -0.159158540902047 0.018493950090324 NA NA NA hsa-miR-200a-3p FOXK1 6.336081120041 4.024313571871e-16 -0.465834645571293 0.329736811197743 mirMAP -0.103834960700135 0.00159619260666165 NA NA NA hsa-miR-200b-3p FOXK1 5.56167217794639 6.43540045061709e-16 -0.465834645571293 0.329736811197743 TargetScan -0.124663713932814 0.000818196841451499 NA NA NA hsa-miR-200a-3p FOXO1 6.336081120041 4.024313571871e-16 -2.60585738485417 1.72557412066164e-08 mirMAP -0.135704169094778 2.82460123175549e-05 NA NA NA hsa-miR-200b-3p FRMD4A 5.56167217794639 6.43540045061709e-16 -0.325430022807841 0.532903928165465 MirTarget;TargetScan -0.10695682145216 0.00878611885177548 NA NA NA hsa-miR-200a-3p FRMD6 6.336081120041 4.024313571871e-16 -1.60821237953985 0.0820702410760675 MirTarget;miRNATAP -0.465768544055995 3.72368449094804e-14 NA NA NA hsa-miR-200b-3p FRMD6 5.56167217794639 6.43540045061709e-16 -1.60821237953985 0.0820702410760675 TargetScan -0.509028109042186 3.51494686896629e-13 NA NA NA hsa-miR-200b-3p FSCN1 5.56167217794639 6.43540045061709e-16 1.49552838426445 0.164345272397435 MirTarget;TargetScan -0.537013575728279 5.71349263405757e-11 27356635 miR 200b inhibits migration and invasion in non small cell lung cancer cells via targeting FSCN1 lung squamous cell cancer hsa-miR-200b-3p FSTL1 5.56167217794639 6.43540045061709e-16 -2.21286155841259 0.0039580105672751 MirTarget;TargetScan -0.277740306176819 3.4352837450652e-06 NA NA NA hsa-miR-200b-3p FYN 5.56167217794639 6.43540045061709e-16 -2.7034719817623 4.90203255667929e-05 TargetScan -0.373264353151448 2.14957850117389e-13 NA NA NA hsa-miR-200b-3p FZD4 5.56167217794639 6.43540045061709e-16 -2.83886953461754 3.72732903465121e-05 mirMAP -0.238298937559481 1.05112124811421e-05 NA NA NA hsa-miR-200b-3p GABRB3 5.56167217794639 6.43540045061709e-16 -3.81599758490219 0.0252774349188719 TargetScan;mirMAP -0.391983341721006 0.0034518994375156 NA NA NA hsa-miR-200b-3p GALNT2 5.56167217794639 6.43540045061709e-16 0.541385667608802 0.258799174122639 MirTarget;TargetScan -0.239597445942828 4.77741510561325e-11 NA NA NA hsa-miR-200a-5p GAS7 6.52092140839401 5.73108242597059e-22 -3.04844932705412 0.000206648898538204 mirMAP -0.432034673873651 5.49500394633022e-12 NA NA NA hsa-miR-200b-5p GAS7 6.81954246537908 6.31100593281326e-24 -3.04844932705412 0.000206648898538204 mirMAP -0.445416072717982 7.59148890608793e-13 NA NA NA hsa-miR-200b-3p GATA2 5.56167217794639 6.43540045061709e-16 -2.95456091104619 0.000416718672082084 TargetScan -0.165864658242104 0.0123023573319192 NA NA NA hsa-miR-200b-3p GBP4 5.56167217794639 6.43540045061709e-16 0.547795633745175 0.600146675214514 mirMAP -0.22724269006482 0.00548658625377397 NA NA NA hsa-miR-200a-3p GDAP1 6.336081120041 4.024313571871e-16 -0.771771066042934 0.347916763174693 miRNAWalker2_validate;miRTarBase -0.207015796259783 0.000250898961102232 NA NA NA hsa-miR-200a-5p GDAP1 6.52092140839401 5.73108242597059e-22 -0.771771066042934 0.347916763174693 MirTarget -0.167909020288361 0.00885972453831093 NA NA NA hsa-miR-200b-5p GDAP1 6.81954246537908 6.31100593281326e-24 -0.771771066042934 0.347916763174693 MirTarget -0.175496635543431 0.00590570567867751 NA NA NA hsa-miR-200b-3p GDF6 5.56167217794639 6.43540045061709e-16 -1.55269438174044 0.352529357077876 TargetScan -0.609131046562882 2.49506902870059e-06 NA NA NA hsa-miR-200a-3p GEM 6.336081120041 4.024313571871e-16 -3.67606699359352 4.72058151247075e-06 MirTarget -0.195426994077563 0.000505322340381016 NA NA NA hsa-miR-200b-3p GEM 5.56167217794639 6.43540045061709e-16 -3.67606699359352 4.72058151247075e-06 MirTarget -0.179934801144683 0.00487280913649338 NA NA NA hsa-miR-200a-3p GFRA1 6.336081120041 4.024313571871e-16 -6.71676086795115 2.48870271326987e-07 mirMAP -0.449742856557626 6.9880162168059e-07 NA NA NA hsa-miR-200a-5p GFRA1 6.52092140839401 5.73108242597059e-22 -6.71676086795115 2.48870271326987e-07 mirMAP -0.60621478190158 2.24205249074192e-09 NA NA NA hsa-miR-200b-3p GFRA1 5.56167217794639 6.43540045061709e-16 -6.71676086795115 2.48870271326987e-07 mirMAP -0.53572318697616 1.74098724989515e-07 NA NA NA hsa-miR-200b-5p GFRA1 6.81954246537908 6.31100593281326e-24 -6.71676086795115 2.48870271326987e-07 mirMAP -0.73619732987866 1.21216793732985e-13 NA NA NA hsa-miR-200a-3p GIMAP1 6.336081120041 4.024313571871e-16 -2.73235708873703 0.000219599124431646 mirMAP -0.332694114256873 3.15845902867419e-11 NA NA NA hsa-miR-200a-3p GJC1 6.336081120041 4.024313571871e-16 -2.92001163442114 0.000785414331230878 MirTarget;miRNATAP -0.241162328265959 6.1419475472714e-05 NA NA NA hsa-miR-200b-3p GJC1 5.56167217794639 6.43540045061709e-16 -2.92001163442114 0.000785414331230878 MirTarget;TargetScan -0.282437430260924 3.41550953121305e-05 NA NA NA hsa-miR-200a-3p GLDN 6.336081120041 4.024313571871e-16 -0.00436019222612338 0.996839198378099 MirTarget -0.165314290570411 0.0300531716118266 NA NA NA hsa-miR-200b-3p GLI3 5.56167217794639 6.43540045061709e-16 -1.9309410842947 0.0645030158335637 TargetScan -0.67763184027715 2.59887609379429e-18 NA NA NA hsa-miR-200b-3p GLIS2 5.56167217794639 6.43540045061709e-16 -1.45877248744844 0.0452621132995041 TargetScan -0.193082921367366 0.000707342891335576 NA NA NA hsa-miR-200b-3p GM2A 5.56167217794639 6.43540045061709e-16 1.58241940756051 0.0144545375110792 TargetScan -0.246744958401399 8.75167431572401e-07 NA NA NA hsa-miR-200a-3p GNA12 6.336081120041 4.024313571871e-16 -1.25516702951645 0.000587921757078316 mirMAP -0.178663238231361 2.63383634041315e-13 NA NA NA hsa-miR-200a-3p GNG7 6.336081120041 4.024313571871e-16 -4.49517936361256 3.6233954247073e-08 MirTarget;miRNATAP -0.307812653397717 5.75243023841078e-08 NA NA NA hsa-miR-200b-3p GPC6 5.56167217794639 6.43540045061709e-16 -2.96127859952068 0.0127527917814679 TargetScan -0.371386452787261 6.44259859278725e-05 NA NA NA hsa-miR-200b-3p GPM6A 5.56167217794639 6.43540045061709e-16 -8.84059407174405 1.11545156178103e-11 TargetScan -0.364154226941257 0.000551327655216422 NA NA NA hsa-miR-200b-3p GPRASP2 5.56167217794639 6.43540045061709e-16 -3.06519822209201 1.39829838724573e-07 MirTarget -0.130695624689375 0.00497456296980382 NA NA NA hsa-miR-200a-3p GRAP2 6.336081120041 4.024313571871e-16 0.198156491420292 0.821747111021549 mirMAP -0.238824878018947 7.55441966092818e-05 NA NA NA hsa-miR-200b-3p GRAP2 5.56167217794639 6.43540045061709e-16 0.198156491420292 0.821747111021549 TargetScan -0.278780310064433 4.52185698527502e-05 NA NA NA hsa-miR-200b-3p GREM1 5.56167217794639 6.43540045061709e-16 -1.90177748877488 0.0936801310258417 MirTarget -0.394723101630866 7.52743404397398e-06 NA NA NA hsa-miR-200b-3p GREM2 5.56167217794639 6.43540045061709e-16 -5.64729272277079 1.72451371347501e-06 TargetScan -0.330327598880849 0.000429151634677032 NA NA NA hsa-miR-200b-3p GRIN2A 5.56167217794639 6.43540045061709e-16 -3.41877778367476 0.0449092732676301 TargetScan -0.371054651625351 0.00560324669022912 NA NA NA hsa-miR-200a-3p GRIN3A 6.336081120041 4.024313571871e-16 -0.284071095763097 0.688514765841374 miRNATAP -0.109967240213902 0.0248650637637946 NA NA NA hsa-miR-200b-3p GRIP1 5.56167217794639 6.43540045061709e-16 1.46258661743498 0.168109776742824 TargetScan -0.274103079249722 0.000956852965575276 NA NA NA hsa-miR-200b-3p GRK5 5.56167217794639 6.43540045061709e-16 -2.31448270715601 0.000119484245798517 TargetScan -0.282876490188617 1.17098842387878e-09 NA NA NA hsa-miR-200b-3p GRM5 5.56167217794639 6.43540045061709e-16 0.989735514391987 0.438577131467529 mirMAP -0.251007019656553 0.0122579396287031 NA NA NA hsa-miR-200b-3p GUCY1A3 5.56167217794639 6.43540045061709e-16 -2.89476216374649 0.000366285735851502 TargetScan -0.212871939911522 0.000889940846976349 NA NA NA hsa-miR-200a-3p HAS2 6.336081120041 4.024313571871e-16 -0.872227689542701 0.541811136420738 MirTarget -0.525505953011924 6.21117966552668e-08 NA NA NA hsa-miR-200b-3p HAS2 5.56167217794639 6.43540045061709e-16 -0.872227689542701 0.541811136420738 TargetScan -0.517271813685405 2.98549710130482e-06 NA NA NA hsa-miR-200a-5p HCFC2 6.52092140839401 5.73108242597059e-22 -0.948206754038386 0.00434815778523131 MirTarget;miRNATAP -0.110321096001228 1.78957218812663e-05 NA NA NA hsa-miR-200b-3p HCFC2 5.56167217794639 6.43540045061709e-16 -0.948206754038386 0.00434815778523131 TargetScan -0.117015630183279 5.68301838834838e-06 NA NA NA hsa-miR-200b-5p HCFC2 6.81954246537908 6.31100593281326e-24 -0.948206754038386 0.00434815778523131 MirTarget -0.130251993736486 2.9592920230452e-07 NA NA NA hsa-miR-200b-3p HECW2 5.56167217794639 6.43540045061709e-16 -0.593381065008276 0.412200542808946 TargetScan -0.214580782441588 0.000139327640774464 NA NA NA hsa-miR-200b-3p HEG1 5.56167217794639 6.43540045061709e-16 -1.10827785583838 0.15703413197601 TargetScan -0.409553831139948 5.62558960350691e-12 NA NA NA hsa-miR-200a-5p HEPH 6.52092140839401 5.73108242597059e-22 -4.20591538983382 2.50319771867583e-05 mirMAP -0.395126323612247 3.73947763976201e-07 NA NA NA hsa-miR-200b-5p HEPH 6.81954246537908 6.31100593281326e-24 -4.20591538983382 2.50319771867583e-05 mirMAP -0.374549303724006 1.33052199725645e-06 NA NA NA hsa-miR-200a-5p HEPHL1 6.52092140839401 5.73108242597059e-22 4.43679891228086 0.0404592156116106 miRNATAP -0.480031833804476 0.00459600174716612 NA NA NA hsa-miR-200a-3p HEYL 6.336081120041 4.024313571871e-16 -3.76008965775318 8.52763734301556e-07 mirMAP -0.269578309578565 3.60670358747742e-07 NA NA NA hsa-miR-200a-3p HGF 6.336081120041 4.024313571871e-16 -3.90177127926037 9.33819406271226e-05 MirTarget -0.280888359064684 5.08617365666383e-05 NA NA NA hsa-miR-200a-3p HIVEP3 6.336081120041 4.024313571871e-16 1.07527826068888 0.187825944811912 mirMAP -0.291997349924996 1.46051676285985e-07 NA NA NA hsa-miR-200a-5p HIVEP3 6.52092140839401 5.73108242597059e-22 1.07527826068888 0.187825944811912 miRNATAP -0.284962938069917 6.18438636853789e-06 NA NA NA hsa-miR-200b-3p HIVEP3 5.56167217794639 6.43540045061709e-16 1.07527826068888 0.187825944811912 TargetScan -0.307331275470056 1.13909189385275e-06 NA NA NA hsa-miR-200b-5p HIVEP3 6.81954246537908 6.31100593281326e-24 1.07527826068888 0.187825944811912 MirTarget -0.262335648023178 2.98320849784759e-05 NA NA NA hsa-miR-200a-3p HOXA11 6.336081120041 4.024313571871e-16 -4.45233816452801 2.55482800271841e-05 miRNATAP -0.324975979051636 9.4867491873402e-06 NA NA NA hsa-miR-200b-3p HOXA5 5.56167217794639 6.43540045061709e-16 -0.654271956570806 0.518637860559183 TargetScan -0.241400265626365 0.00232770242407315 NA NA NA hsa-miR-200a-3p HOXC13 6.336081120041 4.024313571871e-16 6.54183434851218 0.000105232867285768 miRNATAP -0.323552754723448 0.00609955887109674 NA NA NA hsa-miR-200a-3p HPCAL4 6.336081120041 4.024313571871e-16 -0.000112538120211614 0.999927126315635 mirMAP -0.249478226859501 0.00335322927959269 NA NA NA hsa-miR-200b-3p HS3ST3A1 5.56167217794639 6.43540045061709e-16 -0.0166640815374293 0.990169997167972 MirTarget;TargetScan -0.324337652233858 0.00216612235010271 NA NA NA hsa-miR-200a-3p HS3ST3B1 6.336081120041 4.024313571871e-16 -0.0123488088072885 0.991200731053769 mirMAP -0.225603362926185 0.00351046104343968 NA NA NA hsa-miR-200b-3p IER5 5.56167217794639 6.43540045061709e-16 0.580955284755587 0.309125987893715 MirTarget;TargetScan -0.194999958771984 1.0581129675622e-05 NA NA NA hsa-miR-200a-3p IFFO2 6.336081120041 4.024313571871e-16 0.992398977012602 0.24975910932222 MirTarget -0.192842544861072 0.00118170746557958 NA NA NA hsa-miR-200b-3p IFIT5 5.56167217794639 6.43540045061709e-16 -0.156499581265464 0.773424374008228 MirTarget;TargetScan -0.115204545002728 0.00671296341703768 NA NA NA hsa-miR-200a-3p IGDCC4 6.336081120041 4.024313571871e-16 -3.05931605570802 0.000186040060505918 miRNATAP -0.278923449109744 7.54225979376035e-07 NA NA NA hsa-miR-200a-5p IGFBP5 6.52092140839401 5.73108242597059e-22 -4.69502357823987 0.000126115880205647 mirMAP -0.291486571099148 0.00252082489234772 NA NA NA hsa-miR-200a-3p IL1A 6.336081120041 4.024313571871e-16 4.31599389135009 0.0104359859237567 MirTarget -0.461162168953321 7.32399186286365e-05 NA NA NA hsa-miR-200a-3p IL6R 6.336081120041 4.024313571871e-16 -1.31785211161377 0.119283125010066 MirTarget -0.189664840614486 0.00116015340974738 NA NA NA hsa-miR-200b-3p IMMP2L 5.56167217794639 6.43540045061709e-16 -1.54957445049539 0.00992859343791235 MirTarget;TargetScan -0.120802623937083 0.0106346233537442 NA NA NA hsa-miR-200b-3p INHBA 5.56167217794639 6.43540045061709e-16 0.597174749350624 0.643310167999085 TargetScan -0.556231875088492 1.97398662453022e-08 NA NA NA hsa-miR-200b-3p IRS1 5.56167217794639 6.43540045061709e-16 -2.42818243639528 0.00335633570259511 TargetScan -0.1576730203898 0.0158167986513269 26314828 Taken together our results suggest that miR-200 may activate AKT in lung adenocarcinoma cells through a FOG2-independent mechanism involving IRS-1 lung cancer hsa-miR-200a-5p ITGA1 6.52092140839401 5.73108242597059e-22 -1.26498040699148 0.088392048220612 mirMAP -0.272573796738383 1.93794995761484e-06 NA NA NA hsa-miR-200b-3p ITGA1 5.56167217794639 6.43540045061709e-16 -1.26498040699148 0.088392048220612 MirTarget -0.267889806999112 3.26256500212118e-06 NA NA NA hsa-miR-200b-5p ITGA1 6.81954246537908 6.31100593281326e-24 -1.26498040699148 0.088392048220612 mirMAP -0.270528138511657 2.0265899364053e-06 NA NA NA hsa-miR-200b-3p ITGA2 5.56167217794639 6.43540045061709e-16 2.48937739463293 0.0160407654539565 mirMAP -0.300708652888699 0.000201997114046623 NA NA NA hsa-miR-200b-3p ITGA9 5.56167217794639 6.43540045061709e-16 -4.47321269464937 3.75290256398685e-06 mirMAP -0.280092408695882 0.000259584904628051 24518294;26334393 β1 integrin inhibition elicits a prometastatic switch through the TGFβ miR 200 ZEB network in E cadherin positive triple negative breast cancer;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ; breast cancer;esophageal cancer hsa-miR-200a-3p ITGAV 6.336081120041 4.024313571871e-16 -0.352039895655465 0.454432205712453 MirTarget -0.135489080461771 2.53917071546109e-05 NA NA NA hsa-miR-200b-3p ITPR1 5.56167217794639 6.43540045061709e-16 -3.70425443506097 1.11561643309084e-08 TargetScan -0.317146521336074 4.19524850934504e-10 NA NA NA hsa-miR-200b-3p ITPR2 5.56167217794639 6.43540045061709e-16 -0.344004741933712 0.550732070369287 MirTarget -0.257736109163079 5.22603085269682e-09 NA NA NA hsa-miR-200a-3p JAG1 6.336081120041 4.024313571871e-16 0.30392833382371 0.667161126642582 miRNATAP -0.262410845489823 4.31839076896454e-08 NA NA NA hsa-miR-200b-3p JAG2 5.56167217794639 6.43540045061709e-16 0.719956532794578 0.281629881835633 TargetScan;mirMAP -0.105724871286227 0.0440590668413063 21403400 The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR 200 dependent pathway in mice; Mechanistically Jagged2 was found to promote metastasis by increasing the expression of GATA-binding Gata factors which suppressed expression of the microRNA-200 miR-200 family of microRNAs that target the transcriptional repressors that drive EMT and thereby induced EMT metastasis lung cancer hsa-miR-200b-3p JAKMIP2 5.56167217794639 6.43540045061709e-16 -3.34134986575894 0.000628531944891016 TargetScan -0.369152932771206 1.29074255688483e-06 NA NA NA hsa-miR-200a-3p JAZF1 6.336081120041 4.024313571871e-16 -3.33129870532741 1.36253596046008e-08 MirTarget;miRNATAP -0.256124630944989 2.44729527018857e-10 NA NA NA hsa-miR-200b-3p JAZF1 5.56167217794639 6.43540045061709e-16 -3.33129870532741 1.36253596046008e-08 MirTarget;TargetScan -0.319403632663957 2.30233926556993e-12 NA NA NA hsa-miR-200b-3p KANK1 5.56167217794639 6.43540045061709e-16 -1.88289008892227 0.00218127163945131 MirTarget;TargetScan -0.195769797085908 4.6420046263165e-05 NA NA NA hsa-miR-200b-3p KANK2 5.56167217794639 6.43540045061709e-16 -3.73434118557143 3.92460796375949e-15 TargetScan -0.129895313004541 0.000837809104287476 NA NA NA hsa-miR-200b-3p KATNAL1 5.56167217794639 6.43540045061709e-16 -1.62922362530826 0.00106670038821508 TargetScan -0.221013578238483 8.94023283325924e-09 NA NA NA hsa-miR-200b-3p KBTBD8 5.56167217794639 6.43540045061709e-16 1.25303166439357 0.0697142851324238 TargetScan -0.118246665762759 0.02947910825076 NA NA NA hsa-miR-200b-3p KCND2 5.56167217794639 6.43540045061709e-16 -2.7575568771041 0.00594718128613525 MirTarget;TargetScan -0.348489660243773 8.30730071032441e-06 NA NA NA hsa-miR-200b-3p KCNJ15 5.56167217794639 6.43540045061709e-16 2.32044989500366 0.100243162657932 TargetScan -0.32060940522528 0.00378804246335372 NA NA NA hsa-miR-200a-3p KCNK3 6.336081120041 4.024313571871e-16 -3.97793301665669 0.00115285553598102 mirMAP -0.231014560198581 0.00675611651364689 NA NA NA hsa-miR-200b-3p KCTD15 5.56167217794639 6.43540045061709e-16 -0.186105974367814 0.804052250106323 MirTarget;TargetScan -0.216545074874295 0.000209190348001234 NA NA NA hsa-miR-200a-5p KCTD7 6.52092140839401 5.73108242597059e-22 -1.44006345831017 0.000665965842995673 mirMAP -0.10763036379125 0.00115061824265127 NA NA NA hsa-miR-200b-5p KCTD7 6.81954246537908 6.31100593281326e-24 -1.44006345831017 0.000665965842995673 mirMAP -0.117613325145262 0.000344664992271297 NA NA NA hsa-miR-200b-3p KDELC1 5.56167217794639 6.43540045061709e-16 -1.418071405846 0.0151936359926827 TargetScan -0.211376072866449 3.17385349442569e-06 NA NA NA hsa-miR-200b-3p KDR 5.56167217794639 6.43540045061709e-16 -3.78753480302955 5.10405108636238e-08 miRNAWalker2_validate;miRTarBase;TargetScan -0.288850718690057 1.3620986353193e-07 NA NA NA hsa-miR-200b-3p KIAA0040 5.56167217794639 6.43540045061709e-16 -0.676152728535798 0.206396239335536 MirTarget;TargetScan -0.114037856643548 0.00647413992950933 NA NA NA hsa-miR-200a-5p KIAA0355 6.52092140839401 5.73108242597059e-22 -1.30124348911086 0.000105005996772825 MirTarget -0.103953763438809 7.04262577250293e-05 NA NA NA hsa-miR-200b-5p KIAA0355 6.81954246537908 6.31100593281326e-24 -1.30124348911086 0.000105005996772825 MirTarget -0.104469650531169 5.85582726792537e-05 NA NA NA hsa-miR-200b-3p KIAA1462 5.56167217794639 6.43540045061709e-16 -4.21843344330322 1.46499915072858e-09 MirTarget;TargetScan -0.306929957354855 2.60681006463535e-08 NA NA NA hsa-miR-200a-3p KIAA1644 6.336081120041 4.024313571871e-16 -5.72791566907951 3.3324526907743e-07 mirMAP -0.582158480998091 1.84825365035658e-14 NA NA NA hsa-miR-200b-3p KIF13A 5.56167217794639 6.43540045061709e-16 -0.768795091455261 0.214525140898378 TargetScan -0.145519405736678 0.00266480574473625 NA NA NA hsa-miR-200a-3p KIF17 6.336081120041 4.024313571871e-16 -2.99382534054652 7.03585279040111e-05 MirTarget -0.276019995917208 9.77956371218768e-08 NA NA NA hsa-miR-200a-3p KIF3C 6.336081120041 4.024313571871e-16 -0.554973900127337 0.419798394441886 mirMAP -0.256246388248235 3.92337782043791e-08 NA NA NA hsa-miR-200b-3p KLF10 5.56167217794639 6.43540045061709e-16 -0.483478946616828 0.273098643930118 TargetScan -0.139232389552466 4.73393580538324e-05 NA NA NA hsa-miR-200a-3p KLF6 6.336081120041 4.024313571871e-16 -0.875845028436705 0.120819285626917 miRNATAP -0.213224103293039 2.54430014015638e-08 NA NA NA hsa-miR-200a-5p KLF6 6.52092140839401 5.73108242597059e-22 -0.875845028436705 0.120819285626917 miRNATAP -0.205985985343263 2.18809211007932e-06 NA NA NA hsa-miR-200b-3p KLF6 5.56167217794639 6.43540045061709e-16 -0.875845028436705 0.120819285626917 TargetScan -0.238292226792433 4.0766788393063e-08 NA NA NA hsa-miR-200a-5p KLF7 6.52092140839401 5.73108242597059e-22 0.141325846479333 0.865375144696262 miRNATAP -0.160427263662046 0.0136343499692685 NA NA NA hsa-miR-200a-5p KLF9 6.52092140839401 5.73108242597059e-22 -3.69570385779272 1.71840900056727e-08 MirTarget;miRNATAP -0.213467162304836 4.00743057816399e-05 NA NA NA hsa-miR-200b-3p KLF9 5.56167217794639 6.43540045061709e-16 -3.69570385779272 1.71840900056727e-08 TargetScan -0.160153741316414 0.00229657476132049 NA NA NA hsa-miR-200b-5p KLF9 6.81954246537908 6.31100593281326e-24 -3.69570385779272 1.71840900056727e-08 MirTarget -0.225289842617238 1.25923477516807e-05 NA NA NA hsa-miR-200b-3p KLHL3 5.56167217794639 6.43540045061709e-16 -2.04135558829045 0.00444293805485006 TargetScan;mirMAP -0.122822377661879 0.0301327125426296 NA NA NA hsa-miR-200b-3p LAMC1 5.56167217794639 6.43540045061709e-16 -1.1345245467724 0.0487516321194313 MirTarget;TargetScan -0.168074713864644 0.000182531647838776 NA NA NA hsa-miR-200b-3p LATS2 5.56167217794639 6.43540045061709e-16 -1.64065240798514 0.000675576860801643 TargetScan -0.240613824540664 7.94624921697158e-11 NA NA NA hsa-miR-200b-5p LGI2 6.81954246537908 6.31100593281326e-24 -5.12012833009034 3.21508342393231e-05 mirMAP -0.399448726082504 3.19790526074966e-05 NA NA NA hsa-miR-200a-3p LHFP 6.336081120041 4.024313571871e-16 -3.72322745905274 1.33844209793639e-08 MirTarget -0.299792571899803 2.87964194599748e-11 NA NA NA hsa-miR-200b-3p LHFP 5.56167217794639 6.43540045061709e-16 -3.72322745905274 1.33844209793639e-08 MirTarget;TargetScan -0.333033239510363 7.53492704368935e-11 NA NA NA hsa-miR-200a-3p LHX6 6.336081120041 4.024313571871e-16 -2.25699138936336 0.00168408131732467 MirTarget;miRNATAP -0.253807729412159 2.53224872618941e-07 NA NA NA hsa-miR-200a-5p LIMCH1 6.52092140839401 5.73108242597059e-22 -0.59735007213707 0.572787381823852 MirTarget -0.190795744149524 0.0211128920356681 NA NA NA hsa-miR-200b-5p LIMCH1 6.81954246537908 6.31100593281326e-24 -0.59735007213707 0.572787381823852 MirTarget -0.174465794367643 0.0340711273060165 NA NA NA hsa-miR-200b-5p LIN7A 6.81954246537908 6.31100593281326e-24 -4.65222042649615 5.12906307328624e-05 mirMAP -0.277419745343124 0.00207580772560928 NA NA NA hsa-miR-200b-3p LIX1L 5.56167217794639 6.43540045061709e-16 -2.87521613135102 6.70546349738552e-09 MirTarget -0.20586435018682 1.47197476101989e-07 NA NA NA hsa-miR-200b-3p LOX 5.56167217794639 6.43540045061709e-16 0.881717030992129 0.37009820576541 TargetScan -0.15874921770562 0.0399483479743245 NA NA NA hsa-miR-200a-3p LPAR3 6.336081120041 4.024313571871e-16 3.94326410834374 0.00823543381963949 MirTarget -0.286868642990698 0.00566382009527753 NA NA NA hsa-miR-200b-3p LRP1 5.56167217794639 6.43540045061709e-16 -1.64293409792207 0.0130745840537971 TargetScan -0.235281981275946 4.88015159391026e-06 NA NA NA hsa-miR-200a-3p LRRC15 6.336081120041 4.024313571871e-16 -0.286008638098385 0.83843609864784 mirMAP -0.325808781632756 0.000745886746538477 NA NA NA hsa-miR-200a-3p LTBP1 6.336081120041 4.024313571871e-16 -2.15558708391926 0.00223591567779578 MirTarget -0.109072348275159 0.0264517346565534 NA NA NA hsa-miR-200a-3p MAF 6.336081120041 4.024313571871e-16 -1.67642643216486 0.0648843975805926 miRNATAP -0.380237207748509 5.68701233636393e-10 NA NA NA hsa-miR-200a-5p MAF 6.52092140839401 5.73108242597059e-22 -1.67642643216486 0.0648843975805926 miRNATAP -0.430602996633925 4.91956476780094e-10 NA NA NA hsa-miR-200b-3p MAF 5.56167217794639 6.43540045061709e-16 -1.67642643216486 0.0648843975805926 TargetScan -0.428658811933638 7.15748118512178e-10 NA NA NA hsa-miR-200a-3p MAP1B 6.336081120041 4.024313571871e-16 -3.21089551833294 0.00228958674577565 mirMAP -0.353137410212245 1.04080016449107e-06 NA NA NA hsa-miR-200b-3p MAP1B 5.56167217794639 6.43540045061709e-16 -3.21089551833294 0.00228958674577565 TargetScan -0.347434056453392 2.46460784920501e-05 NA NA NA hsa-miR-200a-3p MAP3K3 6.336081120041 4.024313571871e-16 -1.60402819876079 1.58145535314045e-06 miRNATAP -0.119793449484591 1.94872927416047e-07 NA NA NA hsa-miR-200b-3p MAP4K4 5.56167217794639 6.43540045061709e-16 0.189998368969033 0.650968367170234 TargetScan -0.162844985995249 4.65126413003594e-07 NA NA NA hsa-miR-200a-3p MAP7D1 6.336081120041 4.024313571871e-16 0.113058739331047 0.78801892507402 MirTarget;miRNATAP -0.163102059215631 8.85127538829051e-09 NA NA NA hsa-miR-200a-3p MAPKBP1 6.336081120041 4.024313571871e-16 0.16752973369063 0.783570553571303 mirMAP -0.198653417172845 1.75562678265319e-06 NA NA NA hsa-miR-200a-3p MARCH1 6.336081120041 4.024313571871e-16 1.3183736776439 0.0435700403061794 miRNATAP -0.130185839900301 0.0039718032147996 NA NA NA hsa-miR-200b-3p MARCH1 5.56167217794639 6.43540045061709e-16 1.3183736776439 0.0435700403061794 MirTarget -0.149925203834862 0.00342376291627124 NA NA NA hsa-miR-200b-3p MARVELD1 5.56167217794639 6.43540045061709e-16 -1.9353421183878 0.00691257135672042 mirMAP -0.283800279711325 3.24805909268645e-07 NA NA NA hsa-miR-200a-5p MCC 6.52092140839401 5.73108242597059e-22 -0.677048767626195 0.467768009277233 MirTarget -0.423727725345435 2.50357007276183e-09 NA NA NA hsa-miR-200b-3p MCC 5.56167217794639 6.43540045061709e-16 -0.677048767626195 0.467768009277233 TargetScan -0.481022365344772 1.08510166773754e-11 NA NA NA hsa-miR-200b-5p MCC 6.81954246537908 6.31100593281326e-24 -0.677048767626195 0.467768009277233 MirTarget -0.414633669123325 4.59848058464329e-09 NA NA NA hsa-miR-200b-3p MCFD2 5.56167217794639 6.43540045061709e-16 -0.752604438530234 0.0214959371863305 MirTarget;TargetScan -0.138016639963615 3.96070944513377e-08 NA NA NA hsa-miR-200a-3p MDGA1 6.336081120041 4.024313571871e-16 -1.43794814744318 0.156411549925547 miRNATAP -0.171724887519859 0.0145501968929841 NA NA NA hsa-miR-200b-3p MEF2D 5.56167217794639 6.43540045061709e-16 -1.60022304030769 2.0684160611841e-07 TargetScan;mirMAP -0.170641044665909 5.2471485849882e-13 NA NA NA hsa-miR-200b-3p MFAP5 5.56167217794639 6.43540045061709e-16 -6.02112429395012 0.00031991851708567 TargetScan -0.723893619445999 2.53752538100107e-08 NA NA NA hsa-miR-200a-5p MMP16 6.52092140839401 5.73108242597059e-22 -2.72149028413419 0.00811088250623818 mirMAP -0.395600756792997 6.42765962285281e-07 NA NA NA hsa-miR-200b-3p MMP16 5.56167217794639 6.43540045061709e-16 -2.72149028413419 0.00811088250623818 TargetScan -0.351245337086501 1.184394881606e-05 NA NA NA hsa-miR-200b-5p MMP16 6.81954246537908 6.31100593281326e-24 -2.72149028413419 0.00811088250623818 mirMAP -0.383016219479345 1.28601204410987e-06 NA NA NA hsa-miR-200b-3p MOCS1 5.56167217794639 6.43540045061709e-16 -3.08418799358166 0.000934602862706599 TargetScan -0.158586293121629 0.0315982818263404 NA NA NA hsa-miR-200b-3p MPDZ 5.56167217794639 6.43540045061709e-16 -3.47754890216954 0.000677696629805922 MirTarget -0.349106687815393 1.31807292790302e-05 NA NA NA hsa-miR-200b-3p MPRIP 5.56167217794639 6.43540045061709e-16 -1.56361211612266 5.52507002193216e-05 MirTarget;TargetScan -0.13410364906021 9.92674637190537e-06 NA NA NA hsa-miR-200a-3p MR1 6.336081120041 4.024313571871e-16 0.683140161506681 0.232381520940423 mirMAP -0.102178186115718 0.00973441499837838 NA NA NA hsa-miR-200b-3p MRVI1 5.56167217794639 6.43540045061709e-16 -4.87730792862913 1.65805096076273e-10 MirTarget -0.354478463769671 4.37583025714923e-09 NA NA NA hsa-miR-200b-3p MSN 5.56167217794639 6.43540045061709e-16 -0.62674647675537 0.390167415436277 MirTarget;TargetScan -0.52121979764447 1.247491868845e-22 24037528 MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways; Instead we found that miR-200b repressed several actin-associated genes with the knockdown of the ezrin-radixin-moesin family member moesin alone phenocopying the repression of cell invasion by miR-200b; Moesin was verified to be directly targeted by miR-200b and restoration of moesin in miR-200b-expressing cells was sufficient to alleviate metastatic repression; In breast cancer cell lines and patient samples the expression of moesin significantly inversely correlated with miR-200 expression and high levels of moesin were associated with poor relapse-free survival metastasis;poor survival breast cancer hsa-miR-200b-3p MSRB3 5.56167217794639 6.43540045061709e-16 -5.12134814852364 2.69870314210263e-08 mirMAP -0.520033889436895 2.93289043470661e-13 NA NA NA hsa-miR-200a-3p MTSS1 6.336081120041 4.024313571871e-16 1.66969950863621 0.145924953327721 miRNATAP -0.313799373296868 7.01490768691982e-05 NA NA NA hsa-miR-200b-3p MXD1 5.56167217794639 6.43540045061709e-16 1.61228875419633 0.0399212117540836 mirMAP -0.225133419041334 0.00024161177171269 NA NA NA hsa-miR-200a-3p MYH10 6.336081120041 4.024313571871e-16 -2.11011281939029 0.0149760269979194 miRNATAP -0.20397494251209 0.000672156501919757 NA NA NA hsa-miR-200b-3p MYLK 5.56167217794639 6.43540045061709e-16 -5.73620551906387 2.04578586058996e-10 TargetScan -0.549224356851321 3.76765810389303e-15 NA NA NA hsa-miR-200b-3p MYO5A 5.56167217794639 6.43540045061709e-16 -0.133030035892503 0.844074517488657 mirMAP -0.307741682884393 2.71386338467925e-09 NA NA NA hsa-miR-200b-3p NALCN 5.56167217794639 6.43540045061709e-16 -2.96900446210743 0.0245973927525346 MirTarget -0.327682063911802 0.00157290987318637 NA NA NA hsa-miR-200a-3p NAMPT 6.336081120041 4.024313571871e-16 0.248030590609045 0.669986555651829 miRNATAP -0.132775148593464 0.000912029131176357 NA NA NA hsa-miR-200a-5p NAMPT 6.52092140839401 5.73108242597059e-22 0.248030590609045 0.669986555651829 miRNATAP -0.135617033503519 0.0027307417217553 NA NA NA hsa-miR-200a-3p NAV3 6.336081120041 4.024313571871e-16 -4.15438375372593 0.000608306049628081 mirMAP -0.336054904404609 6.2452110874302e-05 NA NA NA hsa-miR-200b-3p NCAM1 5.56167217794639 6.43540045061709e-16 -7.27033620647047 1.60252013841234e-13 TargetScan -0.330360245314913 3.60076000603301e-05 NA NA NA hsa-miR-200a-5p NCF2 6.52092140839401 5.73108242597059e-22 1.7901917083478 0.0100353945671193 MirTarget -0.126154899994765 0.0207367621336601 NA NA NA hsa-miR-200a-3p NCKAP5 6.336081120041 4.024313571871e-16 1.26656070299805 0.264227259252031 MirTarget -0.32682757489365 2.66205066648526e-05 NA NA NA hsa-miR-200b-3p NCS1 5.56167217794639 6.43540045061709e-16 -1.4515534101495 0.0160858802426688 TargetScan -0.327325768426054 8.38384452244266e-13 NA NA NA hsa-miR-200b-3p NDN 5.56167217794639 6.43540045061709e-16 -5.07390710235974 1.70787649675861e-10 MirTarget;TargetScan -0.348457940780557 3.30417797669987e-08 NA NA NA hsa-miR-200b-3p NDST1 5.56167217794639 6.43540045061709e-16 -0.180694031901035 0.708003888406229 TargetScan -0.210329061551156 1.24383249385501e-08 NA NA NA hsa-miR-200a-3p NECAB1 6.336081120041 4.024313571871e-16 -5.74481775614907 1.23311920047135e-07 MirTarget -0.437890057476347 5.57944025897901e-09 NA NA NA hsa-miR-200b-3p NEGR1 5.56167217794639 6.43540045061709e-16 -5.44789313937809 2.41819782942133e-07 TargetScan -0.453285279678578 4.53331113167357e-08 NA NA NA hsa-miR-200a-3p NFASC 6.336081120041 4.024313571871e-16 -2.43145916830151 0.0259317090720814 MirTarget;miRNATAP -0.367150302545668 8.88355756731622e-07 NA NA NA hsa-miR-200b-3p NFASC 5.56167217794639 6.43540045061709e-16 -2.43145916830151 0.0259317090720814 TargetScan;mirMAP -0.413666142786078 1.04044464228222e-06 NA NA NA hsa-miR-200b-3p NKD1 5.56167217794639 6.43540045061709e-16 -1.98089063442873 0.0698165327979292 TargetScan -0.246261562772618 0.00407083131720379 NA NA NA hsa-miR-200b-3p NOG 5.56167217794639 6.43540045061709e-16 -1.21608867705426 0.353623614382544 MirTarget;TargetScan -0.209041601335479 0.0424697035199917 NA NA NA hsa-miR-200a-5p NOS1 6.52092140839401 5.73108242597059e-22 -1.00051482727532 0.516039553599268 mirMAP -0.273849779902172 0.0229362391809995 NA NA NA hsa-miR-200b-3p NOTCH1 5.56167217794639 6.43540045061709e-16 0.769690137962651 0.220066774948586 MirTarget;TargetScan -0.128510800873159 0.00896650356017729 26012256;23430952 Nobiletin inhibited hypoxia induced epithelial mesenchymal transition of lung cancer cells by inactivating of Notch 1 signaling and switching on miR 200b; Our findings suggest that downregulation of Notch-1 and reexpression of miR-200b by nobiletin might be a novel remedy for the therapy of lung cancer;We also found that reexpression of miR-34a and miR-200b by transfection led to reduced expression of Notch-1 resulting in the inhibition of osteosarcoma cell proliferation invasion and angiogenesis ; lung cancer;sarcoma hsa-miR-200a-3p NOTCH3 6.336081120041 4.024313571871e-16 0.618860145042115 0.396379833565062 mirMAP -0.216278824952196 1.48667818246519e-05 NA NA NA hsa-miR-200a-5p NOVA1 6.52092140839401 5.73108242597059e-22 -6.30046281080199 2.82021365108925e-07 miRNATAP -0.427708283007846 9.87148548153539e-06 NA NA NA hsa-miR-200b-3p NOVA1 5.56167217794639 6.43540045061709e-16 -6.30046281080199 2.82021365108925e-07 MirTarget;TargetScan -0.291460627951831 0.00295099683976414 NA NA NA hsa-miR-200b-3p NOVA2 5.56167217794639 6.43540045061709e-16 -3.3500847019059 1.2504810193861e-07 TargetScan -0.296447170646351 2.20616024099099e-09 NA NA NA hsa-miR-200a-3p NPC1 6.336081120041 4.024313571871e-16 0.878389462985171 0.0414945213695943 MirTarget -0.116526435695407 8.1638784717869e-05 NA NA NA hsa-miR-200b-3p NPC1 5.56167217794639 6.43540045061709e-16 0.878389462985171 0.0414945213695943 MirTarget;TargetScan -0.144474408788379 1.56182823199631e-05 NA NA NA hsa-miR-200a-3p NPTX1 6.336081120041 4.024313571871e-16 -2.59547791886019 0.0736335747658508 miRNATAP -0.389190797907368 9.76373333433157e-05 NA NA NA hsa-miR-200b-3p NPTX1 5.56167217794639 6.43540045061709e-16 -2.59547791886019 0.0736335747658508 TargetScan -0.554331918925549 8.13963394101145e-07 NA NA NA hsa-miR-200b-3p NR3C1 5.56167217794639 6.43540045061709e-16 -0.404117136356019 0.444978599376053 TargetScan -0.237113381689093 4.72181073546016e-09 NA NA NA hsa-miR-200b-3p NR5A2 5.56167217794639 6.43540045061709e-16 -3.49575948592341 3.75399384792398e-06 TargetScan -0.16204186634336 0.00710553826956068 NA NA NA hsa-miR-200b-3p NRG1 5.56167217794639 6.43540045061709e-16 3.04350220867378 0.0356408793112703 TargetScan -0.308820407213703 0.00669178337317174 NA NA NA hsa-miR-200b-3p NRIP1 5.56167217794639 6.43540045061709e-16 0.19999841049611 0.713428464989279 MirTarget;TargetScan -0.112922589738504 0.00801475853372333 NA NA NA hsa-miR-200a-3p NRIP3 6.336081120041 4.024313571871e-16 0.135804002942371 0.876701650985585 MirTarget -0.134752611407512 0.0260994143947221 NA NA NA hsa-miR-200a-3p NRP1 6.336081120041 4.024313571871e-16 -1.98099901094797 0.00182281495862403 miRNATAP -0.236836054285976 4.8465401427828e-08 NA NA NA hsa-miR-200a-3p NRP2 6.336081120041 4.024313571871e-16 -2.59016809166495 0.000246120855176714 miRNATAP -0.200489746525561 4.17158072852249e-05 NA NA NA hsa-miR-200b-3p NRP2 5.56167217794639 6.43540045061709e-16 -2.59016809166495 0.000246120855176714 TargetScan -0.187415741901803 0.000767610843036895 NA NA NA hsa-miR-200a-3p NRXN1 6.336081120041 4.024313571871e-16 -4.84696461214275 0.000719813418898303 MirTarget;miRNATAP -0.241657209227534 0.015751854526063 NA NA NA hsa-miR-200a-3p NTRK3 6.336081120041 4.024313571871e-16 -6.52653079118781 1.50303250706945e-07 mirMAP -0.368012707060252 2.35770308707652e-05 NA NA NA hsa-miR-200a-5p NTRK3 6.52092140839401 5.73108242597059e-22 -6.52653079118781 1.50303250706945e-07 mirMAP -0.480334449620966 8.89656761374208e-07 NA NA NA hsa-miR-200b-5p NTRK3 6.81954246537908 6.31100593281326e-24 -6.52653079118781 1.50303250706945e-07 mirMAP -0.568764506663447 3.56697393256227e-09 NA NA NA hsa-miR-200a-3p OLFM1 6.336081120041 4.024313571871e-16 -3.1232292893334 0.0487411602981686 MirTarget;miRNATAP -0.257250029423042 0.0193847388559371 NA NA NA hsa-miR-200a-3p OLFML2A 6.336081120041 4.024313571871e-16 -2.27904771695594 0.0121312350700606 mirMAP -0.439497434061725 5.08547747918279e-13 NA NA NA hsa-miR-200a-3p OSBPL6 6.336081120041 4.024313571871e-16 0.778002767343771 0.528604616838263 MirTarget;miRNATAP -0.258080228044787 0.00245533197506007 NA NA NA hsa-miR-200b-3p OSBPL6 5.56167217794639 6.43540045061709e-16 0.778002767343771 0.528604616838263 mirMAP -0.244984646041586 0.0113866304091386 NA NA NA hsa-miR-200b-3p OSMR 5.56167217794639 6.43540045061709e-16 0.550487651528275 0.505425947189116 TargetScan -0.304673120822428 1.88108458680799e-06 NA NA NA hsa-miR-200b-3p OSTM1 5.56167217794639 6.43540045061709e-16 -1.02726470769602 0.0035410552805802 MirTarget;TargetScan -0.177512644752817 3.75628809948603e-11 NA NA NA hsa-miR-200a-3p P2RX6 6.336081120041 4.024313571871e-16 -1.55234591140838 0.135942812609639 mirMAP -0.330193081411381 3.55967714109871e-06 NA NA NA hsa-miR-200b-3p PAG1 5.56167217794639 6.43540045061709e-16 0.500135604815402 0.380379676491781 MirTarget;TargetScan -0.135776437007927 0.00230024289507525 NA NA NA hsa-miR-200a-3p PALM2-AKAP2 6.336081120041 4.024313571871e-16 -3.06238169861873 2.95962701675291e-06 miRNATAP -0.323066780529058 3.31274525332475e-13 NA NA NA hsa-miR-200a-5p PALM2-AKAP2 6.52092140839401 5.73108242597059e-22 -3.06238169861873 2.95962701675291e-06 mirMAP -0.388390088397143 5.96672097267879e-15 NA NA NA hsa-miR-200b-3p PALM2-AKAP2 5.56167217794639 6.43540045061709e-16 -3.06238169861873 2.95962701675291e-06 TargetScan -0.390924778682707 5.17536152950177e-15 NA NA NA hsa-miR-200b-5p PALM2-AKAP2 6.81954246537908 6.31100593281326e-24 -3.06238169861873 2.95962701675291e-06 mirMAP -0.385003020292086 7.349866930081e-15 NA NA NA hsa-miR-200b-3p PAPLN 5.56167217794639 6.43540045061709e-16 -0.879030574336077 0.263373851669256 TargetScan -0.231774133585463 0.000153583036275803 NA NA NA hsa-miR-200a-3p PAPPA 6.336081120041 4.024313571871e-16 -3.34013495865365 0.00412614758796182 MirTarget;miRNATAP -0.496998649234843 3.01071140118094e-10 NA NA NA hsa-miR-200b-3p PAQR5 5.56167217794639 6.43540045061709e-16 1.64159542875821 0.143142236971782 TargetScan -0.247892893485299 0.00480723257834888 NA NA NA hsa-miR-200b-3p PBX3 5.56167217794639 6.43540045061709e-16 -0.505558470888791 0.295123716408401 TargetScan -0.142074475417812 0.000154425339539925 NA NA NA hsa-miR-200b-3p PCDH10 5.56167217794639 6.43540045061709e-16 -4.02506493515044 0.00207573496528642 MirTarget -0.228085111207851 0.0273735808731872 NA NA NA hsa-miR-200a-3p PCDH17 6.336081120041 4.024313571871e-16 -1.8574501551694 0.00917657523721329 miRNATAP -0.140579786737249 0.00447631376929594 NA NA NA hsa-miR-200a-3p PCDH8 6.336081120041 4.024313571871e-16 -2.04173881346717 0.229076558288945 miRNAWalker2_validate;miRNATAP -0.415357714600526 0.000383131898105606 NA NA NA hsa-miR-200b-3p PCDH8 5.56167217794639 6.43540045061709e-16 -2.04173881346717 0.229076558288945 TargetScan -0.409809371334676 0.00204709192889727 NA NA NA hsa-miR-200b-3p PDE10A 5.56167217794639 6.43540045061709e-16 -2.26684634808676 0.0660741440592912 mirMAP -0.296446104703003 0.00217370141802579 NA NA NA hsa-miR-200b-3p PDE4D 5.56167217794639 6.43540045061709e-16 -1.18822914932299 0.160998936435536 mirMAP -0.13180832438163 0.0479822248108859 NA NA NA hsa-miR-200b-3p PDE7B 5.56167217794639 6.43540045061709e-16 -4.29424253758039 8.18621058906608e-08 TargetScan -0.346490844921274 3.74335150605554e-08 NA NA NA hsa-miR-200a-3p PDGFRA 6.336081120041 4.024313571871e-16 -4.31615823709194 9.59580352063599e-06 MirTarget -0.2276447486551 0.000847664710398646 NA NA NA hsa-miR-200a-3p PFKM 6.336081120041 4.024313571871e-16 -1.47777912301548 0.00929222488070775 MirTarget -0.206229077037854 1.01996405931722e-07 NA NA NA hsa-miR-200b-3p PHEX 5.56167217794639 6.43540045061709e-16 -0.82317683514734 0.473663408286219 MirTarget -0.262665629582862 0.00349021743012708 NA NA NA hsa-miR-200b-3p PHLDB1 5.56167217794639 6.43540045061709e-16 -2.20900839876571 0.000317999124005285 MirTarget;TargetScan -0.149721410285822 0.00198355458411987 NA NA NA hsa-miR-200a-3p PI4K2A 6.336081120041 4.024313571871e-16 0.122858166242368 0.729567038022616 mirMAP -0.109324716748015 6.12745969949242e-06 NA NA NA hsa-miR-200b-3p PICALM 5.56167217794639 6.43540045061709e-16 -0.457801421688647 0.22170228788019 MirTarget -0.164883647687796 8.60318763415182e-09 NA NA NA hsa-miR-200a-3p PKIA 6.336081120041 4.024313571871e-16 0.0870369071914248 0.943688207010343 mirMAP -0.278570491680974 0.00103422724014488 NA NA NA hsa-miR-200b-3p PKIA 5.56167217794639 6.43540045061709e-16 0.0870369071914248 0.943688207010343 MirTarget;TargetScan -0.278557435078045 0.00386970202633927 NA NA NA hsa-miR-200b-3p PKP1 5.56167217794639 6.43540045061709e-16 6.73509817541173 0.00325123853464744 TargetScan -0.601391988238485 0.00083512833176344 NA NA NA hsa-miR-200a-3p PLCL1 6.336081120041 4.024313571871e-16 -4.3220561926702 1.13083584512049e-08 MirTarget -0.42533717459692 8.03960148214159e-17 NA NA NA hsa-miR-200b-3p PLCL1 5.56167217794639 6.43540045061709e-16 -4.3220561926702 1.13083584512049e-08 MirTarget;TargetScan -0.456491897517681 4.57824576803106e-15 NA NA NA hsa-miR-200a-5p PLCXD3 6.52092140839401 5.73108242597059e-22 -7.04776862392773 1.33665946282138e-07 mirMAP -0.261266707172092 0.0143332723491315 NA NA NA hsa-miR-200b-5p PLCXD3 6.81954246537908 6.31100593281326e-24 -7.04776862392773 1.33665946282138e-07 mirMAP -0.356933170641959 0.000726317575597106 NA NA NA hsa-miR-200a-3p PLEK 6.336081120041 4.024313571871e-16 0.947675110737915 0.249923343410534 MirTarget -0.270512617520249 1.49493088569623e-06 NA NA NA hsa-miR-200b-3p PLK2 5.56167217794639 6.43540045061709e-16 -0.350017013516764 0.674788788291004 TargetScan -0.449356675414484 1.04697245867752e-12 NA NA NA hsa-miR-200b-3p PLS3 5.56167217794639 6.43540045061709e-16 -0.662873170341663 0.342486332875389 TargetScan -0.308345881178974 8.53185383253533e-09 NA NA NA hsa-miR-200a-3p PLXNC1 6.336081120041 4.024313571871e-16 -0.705833742044138 0.545902978988465 miRNATAP -0.265551357799285 0.000977433683456671 NA NA NA hsa-miR-200b-3p PLXNC1 5.56167217794639 6.43540045061709e-16 -0.705833742044138 0.545902978988465 TargetScan -0.286004859364868 0.00174973364462074 NA NA NA hsa-miR-200b-3p POU6F1 5.56167217794639 6.43540045061709e-16 -2.91476178856528 1.03056055441303e-07 TargetScan -0.106784810776396 0.014916082901231 NA NA NA hsa-miR-200a-3p PPARGC1A 6.336081120041 4.024313571871e-16 -2.2640615933856 0.188718863271766 mirMAP -0.242011579726154 0.0428918775221476 NA NA NA hsa-miR-200b-3p PPARGC1A 5.56167217794639 6.43540045061709e-16 -2.2640615933856 0.188718863271766 mirMAP -0.340503400297642 0.0118135556010679 NA NA NA hsa-miR-200b-5p PPARGC1A 6.81954246537908 6.31100593281326e-24 -2.2640615933856 0.188718863271766 mirMAP -0.399171743551628 0.00280997425668588 NA NA NA hsa-miR-200a-3p PPFIBP1 6.336081120041 4.024313571871e-16 -0.468327325898124 0.325823142018848 MirTarget -0.11963199414768 0.0002552111812831 NA NA NA hsa-miR-200b-3p PPFIBP1 5.56167217794639 6.43540045061709e-16 -0.468327325898124 0.325823142018848 TargetScan -0.156904131397641 2.1652929871538e-05 NA NA NA hsa-miR-200b-3p PPM1F 5.56167217794639 6.43540045061709e-16 -1.23992186817192 0.00296278064989874 MirTarget;TargetScan -0.253930996350902 4.98664243443017e-16 NA NA NA hsa-miR-200a-3p PPM1K 6.336081120041 4.024313571871e-16 -3.21217087045589 7.67572055014218e-07 MirTarget -0.148661508465858 0.00111809466009774 NA NA NA hsa-miR-200b-3p PPP1R12B 5.56167217794639 6.43540045061709e-16 -4.645606657401 6.27509659817482e-12 TargetScan -0.246893051532547 5.52775738809805e-06 NA NA NA hsa-miR-200b-3p PPP2R2C 5.56167217794639 6.43540045061709e-16 -2.54177583085932 0.149641186912383 TargetScan -0.540897516262644 8.39233236739658e-05 NA NA NA hsa-miR-200b-3p PRDM1 5.56167217794639 6.43540045061709e-16 0.0939045675967058 0.886425550695362 TargetScan -0.200064618750491 9.05029044890409e-05 NA NA NA hsa-miR-200a-3p PRELP 6.336081120041 4.024313571871e-16 -5.61626675274356 1.70477383130157e-06 mirMAP -0.311258539172626 0.000150636048168797 NA NA NA hsa-miR-200b-5p PRELP 6.81954246537908 6.31100593281326e-24 -5.61626675274356 1.70477383130157e-06 mirMAP -0.429478429564132 2.74477988383813e-06 NA NA NA hsa-miR-200a-3p PRKACB 6.336081120041 4.024313571871e-16 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.104144124001908 0.00576356163422443 NA NA NA hsa-miR-200b-3p PRKCB 5.56167217794639 6.43540045061709e-16 -1.37779465994896 0.125783325051528 MirTarget -0.301150868895001 1.67192981795653e-05 NA NA NA hsa-miR-200a-3p PRKD1 6.336081120041 4.024313571871e-16 -3.37242340184957 0.00251240808884675 MirTarget -0.196581168031609 0.0114429812312085 NA NA NA hsa-miR-200b-3p PRKG1 5.56167217794639 6.43540045061709e-16 -4.14478022055911 0.000346396361233345 TargetScan -0.318019023447247 0.000496639657449414 NA NA NA hsa-miR-200b-5p PRRX1 6.81954246537908 6.31100593281326e-24 -3.33510569764646 0.000414916352278086 mirMAP -0.427912643360488 3.30039341200988e-09 NA NA NA hsa-miR-200a-3p PRTG 6.336081120041 4.024313571871e-16 -4.74035707383511 5.79013562364823e-05 MirTarget;miRNATAP -0.381939363607738 2.82003571764195e-06 NA NA NA hsa-miR-200b-3p PTEN 5.56167217794639 6.43540045061709e-16 -0.848820542036926 0.0698463061072717 TargetScan;mirMAP -0.111724552597797 0.00227683849654151 22637745;21408027 Re expression of miR 200 by novel approaches regulates the expression of PTEN and MT1 MMP in pancreatic cancer; We initially compared the expression profile of miR-200 family PTEN and MT1-MMP expression in six pancreatic cancer PC cell lines by qRT-PCR and western blot analysis; The expression of miR-200 family and PTEN was significantly re-expressed whereas the expression of MT1-MMP was down-regulated by CDF and BR-DIM treatment; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants ; pancreatic cancer;pancreatic cancer hsa-miR-200b-3p PTGDR 5.56167217794639 6.43540045061709e-16 -1.47741773711416 0.0581018845333666 TargetScan -0.411605001911149 3.64710039006843e-12 NA NA NA hsa-miR-200a-5p PTGS1 6.52092140839401 5.73108242597059e-22 0.851798650715683 0.431490455676506 mirMAP -0.451534933845443 5.24735614951122e-08 NA NA NA hsa-miR-200b-5p PTGS1 6.81954246537908 6.31100593281326e-24 0.851798650715683 0.431490455676506 mirMAP -0.366132607130226 1.07218547250717e-05 NA NA NA hsa-miR-200b-3p PTHLH 5.56167217794639 6.43540045061709e-16 0.454636912665883 0.774558722511139 MirTarget;TargetScan -0.482681135069172 9.36755055899943e-05 NA NA NA hsa-miR-200b-3p PTP4A1 5.56167217794639 6.43540045061709e-16 0.0576472729143447 0.925844897431291 TargetScan -0.124871975971402 0.0099944370904406 NA NA NA hsa-miR-200b-3p PTPN12 5.56167217794639 6.43540045061709e-16 0.0559418507408829 0.871726101621764 miRNAWalker2_validate;miRTarBase;TargetScan -0.118355671373059 9.48897900229742e-06 NA NA NA hsa-miR-200b-3p PTPN13 5.56167217794639 6.43540045061709e-16 0.294771516623788 0.739722308879297 TargetScan -0.152322380890117 0.0286683445136703 NA NA NA hsa-miR-200b-3p PTPN14 5.56167217794639 6.43540045061709e-16 1.21268976197374 0.00916659148137615 MirTarget;TargetScan -0.138501345439055 0.000138278413942202 NA NA NA hsa-miR-200a-3p PTPRD 6.336081120041 4.024313571871e-16 -5.46044460487346 0.00016227548373706 miRNAWalker2_validate;miRNATAP -0.293671188600894 0.0036806323804299 NA NA NA hsa-miR-200b-3p PTPRD 5.56167217794639 6.43540045061709e-16 -5.46044460487346 0.00016227548373706 miRNAWalker2_validate -0.342830886634331 0.00276965273642119 NA NA NA hsa-miR-200b-3p PYGO1 5.56167217794639 6.43540045061709e-16 -2.44710213372309 0.0639646847724574 mirMAP -0.252818304836589 0.0149456029435887 NA NA NA hsa-miR-200b-5p PYGO1 6.81954246537908 6.31100593281326e-24 -2.44710213372309 0.0639646847724574 mirMAP -0.285568741678693 0.00541832568446563 NA NA NA hsa-miR-200a-5p QKI 6.52092140839401 5.73108242597059e-22 -0.741121261357479 0.0786337799724839 mirMAP -0.187482182795118 5.38003777353237e-09 NA NA NA hsa-miR-200b-3p QKI 5.56167217794639 6.43540045061709e-16 -0.741121261357479 0.0786337799724839 TargetScan -0.228439401623595 7.10196421528497e-13 NA NA NA hsa-miR-200a-3p RAB11FIP2 6.336081120041 4.024313571871e-16 -2.40383301883775 2.3729959132263e-11 MirTarget -0.128912968600649 3.34760953700328e-07 NA NA NA hsa-miR-200b-3p RAB11FIP2 5.56167217794639 6.43540045061709e-16 -2.40383301883775 2.3729959132263e-11 MirTarget;TargetScan -0.135009153101366 2.61023147482882e-06 NA NA NA hsa-miR-200b-3p RAB23 5.56167217794639 6.43540045061709e-16 -2.70073175941914 1.14138176298817e-10 TargetScan -0.110131716924991 0.00109117649358981 NA NA NA hsa-miR-200a-3p RAB30 6.336081120041 4.024313571871e-16 -1.03892493142443 0.0893122492342257 miRNAWalker2_validate;miRNATAP -0.166169046745391 7.62760881168386e-05 NA NA NA hsa-miR-200b-3p RAB30 5.56167217794639 6.43540045061709e-16 -1.03892493142443 0.0893122492342257 mirMAP -0.150495548322003 0.00165627410458584 NA NA NA hsa-miR-200a-3p RAB38 6.336081120041 4.024313571871e-16 2.38660745072971 0.0233454070661479 miRNATAP -0.18945793109024 0.0094938990601508 NA NA NA hsa-miR-200a-3p RAB8B 6.336081120041 4.024313571871e-16 -1.19782846334847 0.00146439299102655 MirTarget -0.166872913530181 4.76840945157006e-11 NA NA NA hsa-miR-200b-3p RAB8B 5.56167217794639 6.43540045061709e-16 -1.19782846334847 0.00146439299102655 TargetScan;mirMAP -0.211373451410663 1.17677782548649e-13 NA NA NA hsa-miR-200b-3p RALB 5.56167217794639 6.43540045061709e-16 -0.333004014658263 0.35233864452784 MirTarget -0.107335580251079 0.000109931988753711 NA NA NA hsa-miR-200a-3p RAP2C 6.336081120041 4.024313571871e-16 -0.963123560669377 0.0108848030318949 MirTarget;miRNATAP -0.147680600331861 8.16539949295919e-09 NA NA NA hsa-miR-200b-3p RAP2C 5.56167217794639 6.43540045061709e-16 -0.963123560669377 0.0108848030318949 MirTarget;TargetScan -0.182615079925735 2.57050071774437e-10 NA NA NA hsa-miR-200a-3p RASA4 6.336081120041 4.024313571871e-16 -3.32083384454286 9.20729082060652e-09 mirMAP -0.199882671471348 7.4580138792015e-07 NA NA NA hsa-miR-200a-3p RASSF2 6.336081120041 4.024313571871e-16 -1.84693151665047 0.00526283577521879 miRNAWalker2_validate -0.146887680408815 0.00136051835005219 NA NA NA hsa-miR-200b-3p RASSF2 5.56167217794639 6.43540045061709e-16 -1.84693151665047 0.00526283577521879 miRNAWalker2_validate -0.153133983238337 0.00326321805198827 NA NA NA hsa-miR-200b-3p RASSF8 5.56167217794639 6.43540045061709e-16 -3.1188523283351 0.000151262443971379 TargetScan -0.239466179802544 0.000222255004200081 NA NA NA hsa-miR-200a-3p RBMS1 6.336081120041 4.024313571871e-16 -1.25516158530751 0.00212730095365255 miRNATAP -0.200579697589717 2.04172450307947e-13 NA NA NA hsa-miR-200b-3p RECK 5.56167217794639 6.43540045061709e-16 -4.28782478538832 5.46316347444686e-08 TargetScan -0.53854914691126 1.62600730793101e-19 NA NA NA hsa-miR-200a-3p RFTN1 6.336081120041 4.024313571871e-16 -2.37179175255667 0.000264217029395198 MirTarget -0.350570636812153 5.59098513621002e-16 NA NA NA hsa-miR-200a-5p RFTN2 6.52092140839401 5.73108242597059e-22 -3.02849389208693 1.37688585695274e-06 MirTarget -0.188441590576228 0.000140179439148337 NA NA NA hsa-miR-200b-3p RFTN2 5.56167217794639 6.43540045061709e-16 -3.02849389208693 1.37688585695274e-06 MirTarget -0.16977200543046 0.000655753383590381 NA NA NA hsa-miR-200b-5p RFTN2 6.81954246537908 6.31100593281326e-24 -3.02849389208693 1.37688585695274e-06 MirTarget -0.217413406242192 9.12319786768207e-06 NA NA NA hsa-miR-200a-5p RIMKLB 6.52092140839401 5.73108242597059e-22 -1.03183217342725 0.12217481239408 MirTarget -0.144257093081673 0.00561078253380437 NA NA NA hsa-miR-200b-3p RIMKLB 5.56167217794639 6.43540045061709e-16 -1.03183217342725 0.12217481239408 MirTarget;TargetScan -0.14790568441933 0.00468479340438262 NA NA NA hsa-miR-200b-5p RIMKLB 6.81954246537908 6.31100593281326e-24 -1.03183217342725 0.12217481239408 MirTarget -0.119818437386262 0.020929940700211 NA NA NA hsa-miR-200a-3p RIMS3 6.336081120041 4.024313571871e-16 -1.70967597118953 0.0650325842672977 mirMAP -0.308713086153458 1.0913488940555e-06 NA NA NA hsa-miR-200b-3p RIMS3 5.56167217794639 6.43540045061709e-16 -1.70967597118953 0.0650325842672977 TargetScan -0.378189732156155 1.25384648034607e-07 NA NA NA hsa-miR-200a-3p RIN2 6.336081120041 4.024313571871e-16 -0.328624378302318 0.467528616545553 miRNAWalker2_validate -0.101004397722349 0.00116110941924639 NA NA NA hsa-miR-200b-3p RND3 5.56167217794639 6.43540045061709e-16 0.677061120886671 0.290268177998675 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.20908723537728 2.598241979802e-05 26935796 MicroRNA 200b inhibits epithelial mesenchymal transition and migration of cervical cancer cells by directly targeting RhoE cervical and endocervical cancer hsa-miR-200a-3p RNF217 6.336081120041 4.024313571871e-16 0.595504046402058 0.426104129412004 mirMAP -0.148317653291356 0.00408237313519788 NA NA NA hsa-miR-200a-3p RORA 6.336081120041 4.024313571871e-16 -1.24412204731139 0.114009602795648 MirTarget;miRNATAP -0.125285648276945 0.0216543447749766 NA NA NA hsa-miR-200b-5p RORA 6.81954246537908 6.31100593281326e-24 -1.24412204731139 0.114009602795648 MirTarget -0.14777025595657 0.015745359651512 NA NA NA hsa-miR-200b-3p RPS6KA2 5.56167217794639 6.43540045061709e-16 -2.65030014005572 0.000604235142902453 TargetScan -0.139665509136457 0.0224100703450016 NA NA NA hsa-miR-200b-3p RUNX1T1 5.56167217794639 6.43540045061709e-16 -4.6090415326702 3.8910513010392e-05 TargetScan -0.326342031672898 0.000226524128852471 NA NA NA hsa-miR-200b-3p RUSC2 5.56167217794639 6.43540045061709e-16 -2.30859670656505 1.38847444083379e-06 TargetScan -0.211239495788855 1.52144148678091e-08 NA NA NA hsa-miR-200a-3p S100A7A 6.336081120041 4.024313571871e-16 5.63511146053128 0.0321550042129653 mirMAP -0.509176473328704 0.00524738923971356 NA NA NA hsa-miR-200a-3p SAMD4A 6.336081120041 4.024313571871e-16 -3.02274280716444 5.18320042685348e-05 miRNATAP -0.33693472072087 3.09737740708075e-11 NA NA NA hsa-miR-200a-3p SCHIP1 6.336081120041 4.024313571871e-16 -1.14861537425891 0.121731314535425 MirTarget -0.105282646733545 0.0408199972582497 NA NA NA hsa-miR-200b-3p SCN2A 5.56167217794639 6.43540045061709e-16 -1.67698295494461 0.364163960938173 MirTarget;TargetScan -0.505713910977779 0.00045716003868374 NA NA NA hsa-miR-200a-3p SCN2B 6.336081120041 4.024313571871e-16 -6.08346532190498 3.4500499981209e-07 MirTarget;miRNATAP -0.497105144013834 1.50468100308316e-09 NA NA NA hsa-miR-200b-3p SCN3A 5.56167217794639 6.43540045061709e-16 -3.01591468571821 0.00670485854462323 mirMAP -0.354908665461207 4.49778876740019e-05 NA NA NA hsa-miR-200b-3p SCN3B 5.56167217794639 6.43540045061709e-16 -3.06176127627563 0.00852381009637453 TargetScan -0.268008422152486 0.0034275597504061 NA NA NA hsa-miR-200a-3p SDC2 6.336081120041 4.024313571871e-16 -3.48496703171104 0.000178061797352628 MirTarget -0.290249656166103 6.29842176945608e-06 NA NA NA hsa-miR-200b-3p SDC2 5.56167217794639 6.43540045061709e-16 -3.48496703171104 0.000178061797352628 TargetScan -0.30381394607346 3.18633228905665e-05 NA NA NA hsa-miR-200b-3p SEC23A 5.56167217794639 6.43540045061709e-16 -1.11132920093232 0.00318125901449351 MirTarget;TargetScan -0.210236033391785 1.59663301025994e-13 NA NA NA hsa-miR-200b-3p SEMA6D 5.56167217794639 6.43540045061709e-16 -2.20177832413999 0.0862979259770274 TargetScan -0.275384152008843 0.00628185097083508 NA NA NA hsa-miR-200a-3p SERPINB13 6.336081120041 4.024313571871e-16 5.78511396298634 0.0336663259486952 MirTarget -0.688619724638814 0.000249722441902617 NA NA NA hsa-miR-200b-3p SERPINI1 5.56167217794639 6.43540045061709e-16 -1.67075782450042 0.0357027927024642 TargetScan -0.129877723594305 0.038148753319146 NA NA NA hsa-miR-200b-3p SESN1 5.56167217794639 6.43540045061709e-16 -1.78011230018704 6.12493041347409e-05 MirTarget;TargetScan -0.146688825292763 2.55312975446406e-05 NA NA NA hsa-miR-200a-5p SESN3 6.52092140839401 5.73108242597059e-22 -0.383534957105207 0.69604184723725 mirMAP -0.156531502984306 0.0413786990552204 NA NA NA hsa-miR-200b-3p SESN3 5.56167217794639 6.43540045061709e-16 -0.383534957105207 0.69604184723725 MirTarget;TargetScan -0.203159343193917 0.00825031783212325 NA NA NA hsa-miR-200a-3p SETBP1 6.336081120041 4.024313571871e-16 -2.39538946374549 0.00498870007119474 miRNATAP -0.272012788591664 3.47675252443772e-06 NA NA NA hsa-miR-200b-3p SETD7 5.56167217794639 6.43540045061709e-16 -1.43322977203362 0.00158498784933718 TargetScan -0.119443206801484 0.000796455700641845 NA NA NA hsa-miR-200b-3p SFMBT2 5.56167217794639 6.43540045061709e-16 -1.49908117039167 0.119418935978856 mirMAP -0.42306154328892 1.08279037936515e-08 NA NA NA hsa-miR-200b-3p SGIP1 5.56167217794639 6.43540045061709e-16 -2.18475545881069 0.00755388449061642 MirTarget;TargetScan -0.28828682379919 6.03936008110361e-06 NA NA NA hsa-miR-200b-3p SGPP1 5.56167217794639 6.43540045061709e-16 -0.989589765875607 0.209372628975208 MirTarget -0.453725034818164 1.99062248373574e-14 NA NA NA hsa-miR-200a-3p SH2B3 6.336081120041 4.024313571871e-16 -1.47178277178044 0.00115664713257855 MirTarget -0.166393243685628 7.45948223214352e-08 NA NA NA hsa-miR-200a-3p SHC1 6.336081120041 4.024313571871e-16 -0.0905023828063758 0.821762372481086 miRNAWalker2_validate -0.158723076319758 4.44716109511501e-09 NA NA NA hsa-miR-200b-3p SHC1 5.56167217794639 6.43540045061709e-16 -0.0905023828063758 0.821762372481086 miRNAWalker2_validate;TargetScan -0.219939119661402 3.38589861822058e-13 NA NA NA hsa-miR-200a-3p SHE 6.336081120041 4.024313571871e-16 -3.680365549955 0.000191992406750442 mirMAP -0.231112633028117 0.000770611218515933 NA NA NA hsa-miR-200b-3p SHE 5.56167217794639 6.43540045061709e-16 -3.680365549955 0.000191992406750442 mirMAP -0.233735773883673 0.00274617222760318 NA NA NA hsa-miR-200a-3p SHROOM4 6.336081120041 4.024313571871e-16 -2.05440419969342 0.0148757283652817 mirMAP -0.119245357006177 0.0421742319334583 NA NA NA hsa-miR-200a-3p SIGLEC1 6.336081120041 4.024313571871e-16 0.807776032083407 0.438160872477265 mirMAP -0.356202271683693 5.21036089314519e-07 NA NA NA hsa-miR-200b-5p SIGLEC8 6.81954246537908 6.31100593281326e-24 0.444647707069717 0.70531455294863 MirTarget -0.34688112325597 0.000129604690416517 NA NA NA hsa-miR-200a-3p SIK1 6.336081120041 4.024313571871e-16 0.681076884994542 0.393172074103663 MirTarget;miRNATAP -0.154118859452747 0.00514698559663867 NA NA NA hsa-miR-200b-3p SIRPA 5.56167217794639 6.43540045061709e-16 -0.192181621402275 0.793659824530169 MirTarget -0.461368925256426 3.08020645090884e-17 NA NA NA hsa-miR-200b-3p SLC16A2 5.56167217794639 6.43540045061709e-16 -2.54993025447742 0.0126293930218215 TargetScan -0.614627578525261 1.33204371755862e-15 NA NA NA hsa-miR-200a-3p SLC22A15 6.336081120041 4.024313571871e-16 1.06029563295729 0.168397066489504 MirTarget -0.172576891789621 0.00115236888490526 NA NA NA hsa-miR-200a-3p SLC23A2 6.336081120041 4.024313571871e-16 -0.932243926078394 0.0333910027677933 miRNATAP -0.139276678858802 3.30570592509445e-06 NA NA NA hsa-miR-200b-3p SLC23A2 5.56167217794639 6.43540045061709e-16 -0.932243926078394 0.0333910027677933 TargetScan -0.164586296500033 1.19786471136532e-06 NA NA NA hsa-miR-200b-3p SLC2A14 5.56167217794639 6.43540045061709e-16 -1.22478391635731 0.190307600373373 TargetScan -0.306797187314822 2.44644197773117e-05 NA NA NA hsa-miR-200b-3p SLC2A3 5.56167217794639 6.43540045061709e-16 -1.81608639562832 0.0147764966199509 TargetScan -0.266808048684777 4.11162871552425e-06 NA NA NA hsa-miR-200b-3p SLC30A4 5.56167217794639 6.43540045061709e-16 -0.331091186907675 0.628347553960278 mirMAP -0.161379801592914 0.00253482860716347 NA NA NA hsa-miR-200b-3p SLC35B4 5.56167217794639 6.43540045061709e-16 -0.586351545913272 0.0782010908501957 MirTarget -0.153657595150972 1.41950755825251e-09 NA NA NA hsa-miR-200a-3p SLC35D1 6.336081120041 4.024313571871e-16 0.162028683865086 0.71932376683248 MirTarget;miRNATAP -0.109195221379305 0.000416015976929229 NA NA NA hsa-miR-200b-3p SLC38A2 5.56167217794639 6.43540045061709e-16 0.116857190667131 0.807292735647725 TargetScan -0.187247402144299 3.81785130291963e-07 NA NA NA hsa-miR-200b-3p SLC38A4 5.56167217794639 6.43540045061709e-16 -2.0101437359495 0.162318834432143 TargetScan -0.60104654736214 5.93000573179322e-08 NA NA NA hsa-miR-200b-3p SLC39A10 5.56167217794639 6.43540045061709e-16 -0.276615981550727 0.630625107994306 mirMAP -0.114447342299084 0.0110256821143542 NA NA NA hsa-miR-200a-5p SLC39A14 6.52092140839401 5.73108242597059e-22 -1.22010635897613 0.0820730241127446 miRNATAP -0.117913605335213 0.0317980781347018 NA NA NA hsa-miR-200b-3p SLC39A14 5.56167217794639 6.43540045061709e-16 -1.22010635897613 0.0820730241127446 TargetScan -0.134802070761482 0.0144321926406289 NA NA NA hsa-miR-200b-3p SLC6A1 5.56167217794639 6.43540045061709e-16 -3.05638630867532 0.000554626267307082 MirTarget;TargetScan -0.353994099764511 2.78316705790012e-07 NA NA NA hsa-miR-200b-3p SLC6A11 5.56167217794639 6.43540045061709e-16 2.6492439478372 0.195712762336309 TargetScan -0.839654549258001 1.05998925143752e-07 NA NA NA hsa-miR-200a-3p SLC6A17 6.336081120041 4.024313571871e-16 1.12303527605864 0.49329365110578 miRNATAP -0.313785269369049 0.00561438708371342 NA NA NA hsa-miR-200b-3p SLC6A17 5.56167217794639 6.43540045061709e-16 1.12303527605864 0.49329365110578 TargetScan;mirMAP -0.417063719722851 0.00113398777295743 NA NA NA hsa-miR-200a-5p SLITRK4 6.52092140839401 5.73108242597059e-22 -3.01623362091086 0.0556329502638095 miRNATAP -0.424051190606483 0.000555172076085087 NA NA NA hsa-miR-200b-3p SMAD7 5.56167217794639 6.43540045061709e-16 -0.95880969992043 0.0366992059513236 TargetScan;mirMAP -0.134092196812711 0.00017837402933657 NA NA NA hsa-miR-200b-3p SNAI2 5.56167217794639 6.43540045061709e-16 -1.63105031719645 0.151947151729511 TargetScan -0.649397403907546 3.78497809111695e-14 NA NA NA hsa-miR-200b-3p SNAP25 5.56167217794639 6.43540045061709e-16 -4.08063911345584 0.00264007465756078 MirTarget;TargetScan -0.379924075071928 0.000366210940452793 NA NA NA hsa-miR-200b-3p SNAPC1 5.56167217794639 6.43540045061709e-16 0.0784831534404722 0.871688295140708 TargetScan -0.122326862373193 0.00123747888968464 NA NA NA hsa-miR-200b-3p SNTB2 5.56167217794639 6.43540045061709e-16 -0.963218903507086 0.0030092179416553 TargetScan -0.105474902700818 2.94869015780087e-05 NA NA NA hsa-miR-200b-3p SPG20 5.56167217794639 6.43540045061709e-16 -2.42586954015214 0.000127431760525772 TargetScan -0.224827840075668 5.78963834460667e-06 NA NA NA hsa-miR-200a-3p SPN 6.336081120041 4.024313571871e-16 0.803475587486631 0.320452591295046 mirMAP -0.180079817232624 0.00123697504605261 NA NA NA hsa-miR-200a-3p SPOCK2 6.336081120041 4.024313571871e-16 -0.133499387675475 0.874287268226174 miRNATAP -0.166601137145949 0.00422337197208961 NA NA NA hsa-miR-200a-3p SPRYD3 6.336081120041 4.024313571871e-16 -1.6702200600354 1.87780089875261e-08 MirTarget;miRNATAP -0.118350349913894 7.3828807119396e-09 NA NA NA hsa-miR-200a-3p SRF 6.336081120041 4.024313571871e-16 -1.61859139334396 3.13150320883435e-07 miRTarBase -0.117259988380599 7.56339573760863e-08 NA NA NA hsa-miR-200b-3p SRF 5.56167217794639 6.43540045061709e-16 -1.61859139334396 3.13150320883435e-07 TargetScan -0.105304515824282 2.42067053148187e-05 NA NA NA hsa-miR-200b-3p ST3GAL2 5.56167217794639 6.43540045061709e-16 -1.82116913003779 2.0100455842577e-05 MirTarget;TargetScan -0.198277852166161 2.01975580430918e-09 NA NA NA hsa-miR-200a-3p ST3GAL5 6.336081120041 4.024313571871e-16 -1.69447377825432 0.0148753838459336 MirTarget -0.285685284946821 1.34571682904323e-09 NA NA NA hsa-miR-200a-3p ST6GALNAC3 6.336081120041 4.024313571871e-16 -4.70303406781754 1.3779426961271e-09 mirMAP -0.296912327205757 4.31785013375635e-08 NA NA NA hsa-miR-200a-5p ST6GALNAC3 6.52092140839401 5.73108242597059e-22 -4.70303406781754 1.3779426961271e-09 MirTarget -0.36992192603275 1.19705775667831e-09 NA NA NA hsa-miR-200b-5p ST6GALNAC3 6.81954246537908 6.31100593281326e-24 -4.70303406781754 1.3779426961271e-09 MirTarget -0.387258619798508 1.3273720826483e-10 NA NA NA hsa-miR-200b-3p ST6GALNAC5 5.56167217794639 6.43540045061709e-16 0.225529673682173 0.833983917458198 TargetScan -0.248327219429621 0.0031771667966712 NA NA NA hsa-miR-200b-3p STARD13 5.56167217794639 6.43540045061709e-16 -2.88914080812798 1.25941330610921e-05 TargetScan -0.234888224930222 6.29887587882444e-06 NA NA NA hsa-miR-200b-3p STARD8 5.56167217794639 6.43540045061709e-16 -3.36381364678495 2.40646928385738e-08 mirMAP -0.363376480606472 4.17300822373361e-15 NA NA NA hsa-miR-200a-3p STAT4 6.336081120041 4.024313571871e-16 0.443436361011697 0.561800373574938 MirTarget -0.282709613251881 4.93960842326004e-08 NA NA NA hsa-miR-200a-3p STAT5A 6.336081120041 4.024313571871e-16 -0.717676705261435 0.218333398036409 MirTarget;miRNATAP -0.128916767921046 0.00133172867013861 NA NA NA hsa-miR-200a-3p STAT5B 6.336081120041 4.024313571871e-16 -2.15100735109765 1.31811971048943e-10 MirTarget;miRNATAP -0.140099562865409 1.63595175829897e-09 NA NA NA hsa-miR-200a-5p STX2 6.52092140839401 5.73108242597059e-22 -1.82780299800702 0.000156821644766899 MirTarget -0.181815132122972 1.29259868908159e-06 NA NA NA hsa-miR-200b-5p STX2 6.81954246537908 6.31100593281326e-24 -1.82780299800702 0.000156821644766899 MirTarget -0.17466090420303 2.99868090279477e-06 NA NA NA hsa-miR-200b-3p SULF1 5.56167217794639 6.43540045061709e-16 -1.18113811961141 0.222780303266628 MirTarget;TargetScan -0.253130631567768 0.000828213165676731 NA NA NA hsa-miR-200a-3p SULF2 6.336081120041 4.024313571871e-16 -1.61802197581169 0.0632663761703677 MirTarget -0.356056413008145 1.52391175788877e-09 NA NA NA hsa-miR-200a-3p SV2B 6.336081120041 4.024313571871e-16 -2.05886345743427 0.106689040731223 MirTarget -0.393907216701121 6.65218615554519e-06 NA NA NA hsa-miR-200b-3p SV2B 5.56167217794639 6.43540045061709e-16 -2.05886345743427 0.106689040731223 mirMAP -0.410663831983994 3.59613458192616e-05 NA NA NA hsa-miR-200a-3p SVIL 6.336081120041 4.024313571871e-16 -2.16603439012136 0.000169143910266012 miRNATAP -0.144205054428999 0.000312106661213708 NA NA NA hsa-miR-200b-3p SYDE1 5.56167217794639 6.43540045061709e-16 -2.73422804199318 0.000797548057676696 MirTarget;TargetScan -0.56828062945684 4.86559328627e-21 NA NA NA hsa-miR-200b-3p SYNC 5.56167217794639 6.43540045061709e-16 -2.34330197802536 0.0609083259425116 MirTarget -0.294037905630542 0.00271807394439442 NA NA NA hsa-miR-200a-3p SYNPO2 6.336081120041 4.024313571871e-16 -6.02534023925443 1.18750031786196e-09 miRNATAP -0.327333698318118 2.61672724548843e-06 NA NA NA hsa-miR-200a-5p SYNPO2 6.52092140839401 5.73108242597059e-22 -6.02534023925443 1.18750031786196e-09 mirMAP -0.4212820520648 7.10166600779392e-08 NA NA NA hsa-miR-200b-3p SYNPO2 5.56167217794639 6.43540045061709e-16 -6.02534023925443 1.18750031786196e-09 mirMAP -0.302771531166655 0.000138550333610582 NA NA NA hsa-miR-200b-5p SYNPO2 6.81954246537908 6.31100593281326e-24 -6.02534023925443 1.18750031786196e-09 mirMAP -0.438144817718122 1.61054220974041e-08 NA NA NA hsa-miR-200b-3p SYT1 5.56167217794639 6.43540045061709e-16 -5.26036758097741 0.00105227161276887 MirTarget;TargetScan -0.381399145013224 0.00261112041640587 NA NA NA hsa-miR-200b-3p SYT11 5.56167217794639 6.43540045061709e-16 -3.43609270126513 2.66041213521335e-07 mirMAP -0.211242296508114 6.73061580161805e-05 NA NA NA hsa-miR-200a-3p TANC2 6.336081120041 4.024313571871e-16 0.847080523135286 0.158360883071967 miRNATAP -0.139382370351797 0.000752502149217951 NA NA NA hsa-miR-200b-3p TAOK3 5.56167217794639 6.43540045061709e-16 0.114043662398584 0.775639161459909 MirTarget;TargetScan -0.125124985839417 5.41879477615287e-05 NA NA NA hsa-miR-200b-3p TBX18 5.56167217794639 6.43540045061709e-16 -1.77367755407136 0.39423688521135 MirTarget -0.407016953730907 0.0127175364420914 NA NA NA hsa-miR-200a-3p TCF4 6.336081120041 4.024313571871e-16 -2.23433165372064 0.00194262002575201 MirTarget;miRNATAP -0.149865909046394 0.00277665020452694 NA NA NA hsa-miR-200a-5p TCF4 6.52092140839401 5.73108242597059e-22 -2.23433165372064 0.00194262002575201 mirMAP;miRNATAP -0.124694684110452 0.0279430579186702 NA NA NA hsa-miR-200b-5p TCF4 6.81954246537908 6.31100593281326e-24 -2.23433165372064 0.00194262002575201 mirMAP -0.141959447362055 0.0117406859303621 NA NA NA hsa-miR-200a-3p TCF7L1 6.336081120041 4.024313571871e-16 -2.01358509693913 0.0134449848880761 miRNAWalker2_validate -0.203461925521664 0.000299485175056615 NA NA NA hsa-miR-200b-3p TCF7L1 5.56167217794639 6.43540045061709e-16 -2.01358509693913 0.0134449848880761 miRNAWalker2_validate -0.213878073046112 0.000814272240549089 NA NA NA hsa-miR-200b-3p TCP11L1 5.56167217794639 6.43540045061709e-16 -0.308888724098123 0.534879370589562 MirTarget -0.220058417183661 7.6480774164243e-09 NA NA NA hsa-miR-200b-3p TES 5.56167217794639 6.43540045061709e-16 -1.24885860530538 0.00048431500063247 MirTarget -0.11157039059002 6.6705973049125e-05 NA NA NA hsa-miR-200a-3p TET1 6.336081120041 4.024313571871e-16 -1.1952500612559 0.220389914669266 MirTarget -0.160621118688924 0.0174092556316895 NA NA NA hsa-miR-200b-3p TFEC 5.56167217794639 6.43540045061709e-16 1.26240633687076 0.158826021061427 MirTarget -0.305746057260168 1.11226793472507e-05 NA NA NA hsa-miR-200b-3p TFPI 5.56167217794639 6.43540045061709e-16 -2.99865686822915 0.00698823320919658 MirTarget -0.41881843784017 1.26543666698896e-06 NA NA NA hsa-miR-200a-3p TGFB2 6.336081120041 4.024313571871e-16 -1.43663821995393 0.208151431685717 MirTarget;miRNATAP -0.351128170275698 7.00885632360109e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-200b-3p TGFBR1 5.56167217794639 6.43540045061709e-16 -0.505713612135208 0.324744061078335 mirMAP -0.254716587127543 6.86106889972148e-11 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-200a-5p THBS1 6.52092140839401 5.73108242597059e-22 -3.75129916683394 0.000103499881096753 MirTarget -0.485719624657622 5.54901388898712e-11 NA NA NA hsa-miR-200b-5p THBS1 6.81954246537908 6.31100593281326e-24 -3.75129916683394 0.000103499881096753 MirTarget -0.501001329221048 9.13787343375865e-12 NA NA NA hsa-miR-200b-3p THEMIS 5.56167217794639 6.43540045061709e-16 0.601231411570227 0.548820685370486 mirMAP -0.166373435189551 0.0345952254878357 NA NA NA hsa-miR-200b-3p TIMP2 5.56167217794639 6.43540045061709e-16 -3.59794494522838 2.10429352476442e-07 TargetScan -0.352441008419398 6.09383296196395e-11 23205572 A novel target of miR-200b tissue inhibitor of metalloproteinase 2 TIMP2 was predicted using a bioinformatics approach and was confirmed in human endometrial cancer cell line HEC-1A cells by luciferase assay quantitative real-time polymerase chain reaction western blotting and enzyme-linked immunosorbent assay; We found that miR-200b repressed TIMP2 expression at both the messenger RNA and protein levels although a family member miR-200a had no such effect; Using reverse gelatin zymography we showed that miR-200b enhances matrix metallopeptidase 2 MMP2 activity by downregulating TIMP2 expression in HEC-1A cells endometrial cancer hsa-miR-200b-3p TLN1 5.56167217794639 6.43540045061709e-16 -1.69309268157312 1.12927629704341e-07 TargetScan -0.204285218607752 2.66602484014393e-17 NA NA NA hsa-miR-200a-3p TMEFF1 6.336081120041 4.024313571871e-16 -0.576201765093648 0.402191436031652 MirTarget -0.120014302604118 0.0115899657782312 NA NA NA hsa-miR-200a-3p TMEM130 6.336081120041 4.024313571871e-16 -3.4516648419652 0.00494436357179222 MirTarget -0.276953504045993 0.00114742263687834 NA NA NA hsa-miR-200b-3p TMEM136 5.56167217794639 6.43540045061709e-16 -2.25661551376261 0.000859424259322335 TargetScan -0.128403265777105 0.0164392331028244 NA NA NA hsa-miR-200a-3p TMEM154 6.336081120041 4.024313571871e-16 2.97622201855108 0.00210650180987161 mirMAP -0.172850794392657 0.01034969045718 NA NA NA hsa-miR-200b-3p TMEM43 5.56167217794639 6.43540045061709e-16 -1.33845768171733 0.000183832694314726 MirTarget -0.158503197635091 9.70681220483324e-09 NA NA NA hsa-miR-200a-5p TMOD2 6.52092140839401 5.73108242597059e-22 -1.55872706933157 0.0221432294070425 mirMAP -0.29985826854417 9.25418041328678e-09 NA NA NA hsa-miR-200b-5p TMOD2 6.81954246537908 6.31100593281326e-24 -1.55872706933157 0.0221432294070425 mirMAP -0.288779231084242 2.7968528309346e-08 NA NA NA hsa-miR-200a-3p TNS1 6.336081120041 4.024313571871e-16 -4.16184727364964 6.30642759601797e-10 MirTarget -0.205609402942134 1.48280234426297e-05 NA NA NA hsa-miR-200a-3p TP63 6.336081120041 4.024313571871e-16 5.85793776537445 0.00832901433456591 MirTarget -0.618284807033249 5.4455766137516e-05 NA NA NA hsa-miR-200a-3p TRHDE 6.336081120041 4.024313571871e-16 -5.36984249731735 0.000470493331087257 MirTarget -0.338321826006967 0.00155760077421747 NA NA NA hsa-miR-200b-3p TRHDE 5.56167217794639 6.43540045061709e-16 -5.36984249731735 0.000470493331087257 MirTarget;TargetScan -0.283820474137585 0.0196665766221318 NA NA NA hsa-miR-200b-3p TRIL 5.56167217794639 6.43540045061709e-16 -2.04685940357468 0.0791263282500526 MirTarget -0.311518352587091 0.00063710004334837 NA NA NA hsa-miR-200b-3p TRIO 5.56167217794639 6.43540045061709e-16 -0.101114507829679 0.867711480406222 TargetScan -0.109143237428229 0.0217438656114236 NA NA NA hsa-miR-200b-3p TSC22D2 5.56167217794639 6.43540045061709e-16 -0.148209592814013 0.773795299954636 MirTarget;TargetScan -0.145810917750154 0.000278053785422374 NA NA NA hsa-miR-200a-3p TSHZ3 6.336081120041 4.024313571871e-16 -3.16568181185487 0.000170463582155262 MirTarget;miRNATAP -0.251957735450446 1.54075583032322e-05 NA NA NA hsa-miR-200a-3p TTBK2 6.336081120041 4.024313571871e-16 -0.34689133781282 0.614504770237231 MirTarget -0.122841583476226 0.00982464698007919 NA NA NA hsa-miR-200a-3p TTYH2 6.336081120041 4.024313571871e-16 -2.45357393292491 0.00472130381204133 miRNATAP -0.404013129253288 4.69776967896099e-12 NA NA NA hsa-miR-200b-3p TUBB2A 5.56167217794639 6.43540045061709e-16 -0.550417887940897 0.419400382781808 MirTarget -0.136609188775926 0.0105189282561103 NA NA NA hsa-miR-200b-3p TUBB3 5.56167217794639 6.43540045061709e-16 2.5969248323706 0.00336675274967247 TargetScan -0.178429161519801 0.0106602964881574 NA NA NA hsa-miR-200a-5p TXLNB 6.52092140839401 5.73108242597059e-22 -3.81339030276338 5.30878429080659e-06 MirTarget -0.363580632095743 2.36597990930709e-08 NA NA NA hsa-miR-200b-5p TXLNB 6.81954246537908 6.31100593281326e-24 -3.81339030276338 5.30878429080659e-06 MirTarget -0.388764565555543 1.65343116658169e-09 NA NA NA hsa-miR-200a-3p TXNIP 6.336081120041 4.024313571871e-16 -2.57627281923689 0.000174676475402869 MirTarget -0.108099547004618 0.0243581000447631 NA NA NA hsa-miR-200b-3p USH1G 5.56167217794639 6.43540045061709e-16 0.828968869575843 0.606130544621373 TargetScan;mirMAP -0.304666707054966 0.0157155102430183 NA NA NA hsa-miR-200b-3p USP31 5.56167217794639 6.43540045061709e-16 -0.678837940286817 0.134901889034998 MirTarget;TargetScan -0.16358073303759 3.18602660628117e-06 NA NA NA hsa-miR-200b-3p VASH1 5.56167217794639 6.43540045061709e-16 -0.917164494819347 0.0963184146908343 MirTarget;TargetScan -0.204487063578473 1.65206149139084e-06 NA NA NA hsa-miR-200b-3p VAT1L 5.56167217794639 6.43540045061709e-16 -3.11238247729384 0.00744662175909513 MirTarget;TargetScan -0.340862515834445 0.000183501963224139 NA NA NA hsa-miR-200a-3p VCAM1 6.336081120041 4.024313571871e-16 -1.53361282607347 0.132965096563532 miRNAWalker2_validate -0.237886699290587 0.000728103222771694 NA NA NA hsa-miR-200a-3p VCAN 6.336081120041 4.024313571871e-16 -0.93481074618867 0.393275413305526 MirTarget;miRNATAP -0.338711454057603 6.11427016106795e-06 NA NA NA hsa-miR-200b-3p VGLL3 5.56167217794639 6.43540045061709e-16 -3.67857910192456 0.00250435275558057 mirMAP -0.582344316161594 4.97827585639376e-10 NA NA NA hsa-miR-200b-3p WASF1 5.56167217794639 6.43540045061709e-16 -0.348929262192005 0.609944445673327 TargetScan -0.165183227693097 0.00199167457146057 NA NA NA hsa-miR-200a-3p WASF3 6.336081120041 4.024313571871e-16 -2.83975078195081 0.0107635104996704 miRNAWalker2_validate;miRTarBase -0.370566670332409 1.20388426244304e-06 NA NA NA hsa-miR-200b-3p WASF3 5.56167217794639 6.43540045061709e-16 -2.83975078195081 0.0107635104996704 miRNAWalker2_validate;miRTarBase;TargetScan -0.381529490081687 1.11041872173565e-05 NA NA NA hsa-miR-200a-3p WDFY4 6.336081120041 4.024313571871e-16 0.464571757788814 0.618054304059736 mirMAP -0.220808476095982 0.000575424283692605 NA NA NA hsa-miR-200b-3p WDR91 5.56167217794639 6.43540045061709e-16 0.773700856092556 0.181898929895563 MirTarget;TargetScan -0.226892457251214 3.89851952447368e-07 NA NA NA hsa-miR-200a-3p WIPF1 6.336081120041 4.024313571871e-16 -1.3199372564298 0.0475876731819671 MirTarget;miRNATAP -0.290539410838852 9.43803663685651e-11 NA NA NA hsa-miR-200b-3p WIPF1 5.56167217794639 6.43540045061709e-16 -1.3199372564298 0.0475876731819671 MirTarget;TargetScan -0.367903906798664 2.89360356929466e-13 NA NA NA hsa-miR-200a-3p WNK1 6.336081120041 4.024313571871e-16 0.225279658220879 0.62839966029964 MirTarget -0.104649882131654 0.00107138524312387 NA NA NA hsa-miR-200a-5p WNK1 6.52092140839401 5.73108242597059e-22 0.225279658220879 0.62839966029964 MirTarget;miRNATAP -0.115791552243636 0.00134631288227363 NA NA NA hsa-miR-200b-5p WNK1 6.81954246537908 6.31100593281326e-24 0.225279658220879 0.62839966029964 MirTarget -0.129642787448528 0.000296671143018589 NA NA NA hsa-miR-200a-3p WTIP 6.336081120041 4.024313571871e-16 -2.28702770726066 0.00408409230581306 mirMAP -0.156082728816863 0.00479238591310846 NA NA NA hsa-miR-200a-3p WWC2 6.336081120041 4.024313571871e-16 -1.34225338097679 0.101970469081228 mirMAP -0.191397026025281 0.000722748274835612 NA NA NA hsa-miR-200b-3p WWC3 5.56167217794639 6.43540045061709e-16 -0.224757554486379 0.595853377699312 MirTarget;TargetScan -0.128868080509362 8.84375257274407e-05 NA NA NA hsa-miR-200b-3p XG 5.56167217794639 6.43540045061709e-16 1.46373614561368 0.351919903205425 MirTarget -0.456158623599398 0.000199151811283292 NA NA NA hsa-miR-200b-3p XKR6 5.56167217794639 6.43540045061709e-16 0.111282891500067 0.922180948731624 TargetScan -0.33039716604243 0.00019700211527387 NA NA NA hsa-miR-200b-5p XYLT1 6.81954246537908 6.31100593281326e-24 -1.12818083225192 0.230679101009796 mirMAP -0.240028878297375 0.0009818900021243 NA NA NA hsa-miR-200a-3p YAP1 6.336081120041 4.024313571871e-16 -0.717460133341563 0.36094816300211 miRNAWalker2_validate;MirTarget -0.205369128575749 0.000140866111002424 23340296 MicroRNA 200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer; We identified Yes-associated protein 1 YAP1 as a novel target of miR-200a; Our data showed that targeting of YAP1 by miR-200a resulted in decreased expression of proapoptotic proteins which leads to anoikis resistance; Remarkably we found that YAP1 expression was inversely correlated with miR-200a expression in breast cancer clinical specimens and miR-200a expression was associated with distant metastasis in patients with breast cancer metastasis;drug resistance breast cancer hsa-miR-200b-3p YAP1 5.56167217794639 6.43540045061709e-16 -0.717460133341563 0.36094816300211 MirTarget -0.294415125862106 1.23893734345189e-06 NA NA NA hsa-miR-200a-3p YWHAG 6.336081120041 4.024313571871e-16 0.385447226562581 0.259836541396253 MirTarget;miRNATAP -0.102315490044077 1.13196642995869e-05 NA NA NA hsa-miR-200b-3p YWHAG 5.56167217794639 6.43540045061709e-16 0.385447226562581 0.259836541396253 MirTarget;TargetScan -0.11446043266416 1.4853090925883e-05 NA NA NA hsa-miR-200b-3p ZBTB16 5.56167217794639 6.43540045061709e-16 -6.80935672859994 1.0265715735251e-08 TargetScan -0.442613277664109 2.81717231091296e-06 NA NA NA hsa-miR-200b-3p ZBTB38 5.56167217794639 6.43540045061709e-16 -1.12769614114666 0.0433628483658275 TargetScan -0.139459392429801 0.00141222317563756 NA NA NA hsa-miR-200a-3p ZC3H12C 6.336081120041 4.024313571871e-16 -1.1370756536503 0.104826841919012 MirTarget -0.109009827211784 0.0248656146274024 NA NA NA hsa-miR-200a-5p ZC3H12C 6.52092140839401 5.73108242597059e-22 -1.1370756536503 0.104826841919012 MirTarget;miRNATAP -0.169750013670193 0.00188862215238333 NA NA NA hsa-miR-200b-3p ZC3H12C 5.56167217794639 6.43540045061709e-16 -1.1370756536503 0.104826841919012 TargetScan -0.179313166256362 0.00107354380090389 NA NA NA hsa-miR-200b-5p ZC3H12C 6.81954246537908 6.31100593281326e-24 -1.1370756536503 0.104826841919012 MirTarget -0.162779724015245 0.00274448292973552 NA NA NA hsa-miR-200a-3p ZCCHC24 6.336081120041 4.024313571871e-16 -4.22525928068511 2.98299090136584e-13 MirTarget;miRNATAP -0.290237328315889 5.3886531851625e-13 NA NA NA hsa-miR-200b-3p ZCCHC24 5.56167217794639 6.43540045061709e-16 -4.22525928068511 2.98299090136584e-13 MirTarget;TargetScan -0.354819030736291 4.53472119236456e-15 NA NA NA hsa-miR-200a-3p ZEB1 6.336081120041 4.024313571871e-16 -4.15148040615949 1.11507739514902e-09 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.320606547731732 8.624279344328e-12 27402864;27402080;23743934;24815002;24424572;20473948;19854497;26887977;24390222;26242262;19544444;23626803;24037528 This circuit comprises the microRNA 200 miR-200 family ZEB1 and GRHL2;Conversely ectopic expression of miR-200 inhibited this sprouting by indirectly reducing the protein levels of PDGFRβ through the direct suppression of ZEB1;This finding was accompanied by a sharp downregulation in the expression of the miR-200 family of microRNAs well-known targets of ZEB1;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;ZEB1 is also known to repress miR-200c-141 transcription in a negative feedback loop but otherwise little is known about the transcriptional regulation of the miR-200 family and miR-205;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;GRHL2 miR 200 ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification;Inhibition of ZEB1 by miR 200 characterizes Helicobacter pylori positive gastric diffuse large B cell lymphoma with a less aggressive behavior; Through genome-wide expression profiles of both miRNAs and mRNAs in nine H pylori-positive and nine H pylori-negative gastric diffuse large B-cell lymphomas we identified inhibition of ZEB1 zinc-finger E-box-binding homeobox 1 by miR-200 in H pylori-positive gastric diffuse large B-cell lymphomas; In 30 H pylori-positive and 30 H pylori-negative gastric diffuse large B-cell lymphomas we confirmed that H pylori-positive gastric diffuse large B-cell lymphomas had higher levels of miR-200 by qRT-PCR and lower levels of ZEB1 and higher levels of BCL6 using immunohistochemistry;MiR 200 suppresses metastases of colorectal cancer through ZEB1; Here we showed that the levels of miR-200 were significantly decreased and the levels of ZEB1 were significantly increased in the CRC specimens from patients compared to the paired non-tumor tissue; Moreover the levels of miR-200 and ZEB1 are inversely correlated; Bioinformatics analyses showed that miR-200 targeted the 3'-UTR of ZEB1 mRNA to inhibit its translation which was confirmed by luciferase reporter assay;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;Concomitant with miR-200 decrease there was an increase in ZEB1 mRNA expression;MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways ;;;;tumorigenesis;;;;;metastasis;;;metastasis sarcoma;breast cancer;endometrial cancer;sarcoma;head and neck cancer;bladder cancer;ovarian cancer;ovarian cancer;B cell lymphoma;colorectal cancer;prostate cancer;breast cancer;breast cancer hsa-miR-200b-3p ZEB1 5.56167217794639 6.43540045061709e-16 -4.15148040615949 1.11507739514902e-09 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.379741542803846 8.03366958751335e-13 24352645;27402864;27402080;23743934;24815002;24424572;20473948;26011542;19854497;26887977;24390222;27307751;26242262;19544444;23626803;26783187;24037528 Functional experiments demonstrated that miR-200b suppressed ZEB1 augmented E-cadherin inhibited cell migration and suppressed tumor growth in a mouse model;This circuit comprises the microRNA 200 miR-200 family ZEB1 and GRHL2;Conversely ectopic expression of miR-200 inhibited this sprouting by indirectly reducing the protein levels of PDGFRβ through the direct suppression of ZEB1;This finding was accompanied by a sharp downregulation in the expression of the miR-200 family of microRNAs well-known targets of ZEB1;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;ZEB1 is also known to repress miR-200c-141 transcription in a negative feedback loop but otherwise little is known about the transcriptional regulation of the miR-200 family and miR-205;Here we show that 53BP1 negatively regulated EMT by modulating ZEB1 through targeting microRNA miR-200b and miR-429; In 18 clinical tissue samples expression of 53BP1 was positively correlated with miR-200b and mir-429 and negatively correlated with ZEB1;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;GRHL2 miR 200 ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification;Inhibition of ZEB1 by miR 200 characterizes Helicobacter pylori positive gastric diffuse large B cell lymphoma with a less aggressive behavior; Through genome-wide expression profiles of both miRNAs and mRNAs in nine H pylori-positive and nine H pylori-negative gastric diffuse large B-cell lymphomas we identified inhibition of ZEB1 zinc-finger E-box-binding homeobox 1 by miR-200 in H pylori-positive gastric diffuse large B-cell lymphomas; In 30 H pylori-positive and 30 H pylori-negative gastric diffuse large B-cell lymphomas we confirmed that H pylori-positive gastric diffuse large B-cell lymphomas had higher levels of miR-200 by qRT-PCR and lower levels of ZEB1 and higher levels of BCL6 using immunohistochemistry;MicroRNA 200b acts as a tumor suppressor in osteosarcoma via targeting ZEB1; Moreover ZEB1 was identified as a target gene of miR-200b and its expression levels were negatively mediated by miR-200b in osteosarcoma cells; Based on these findings our study suggests that miR-200b inhibits the proliferation migration and invasion of osteosarcoma cells probably via the inhibition of ZEB1 expression;MiR 200 suppresses metastases of colorectal cancer through ZEB1; Here we showed that the levels of miR-200 were significantly decreased and the levels of ZEB1 were significantly increased in the CRC specimens from patients compared to the paired non-tumor tissue; Moreover the levels of miR-200 and ZEB1 are inversely correlated; Bioinformatics analyses showed that miR-200 targeted the 3'-UTR of ZEB1 mRNA to inhibit its translation which was confirmed by luciferase reporter assay;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;Concomitant with miR-200 decrease there was an increase in ZEB1 mRNA expression; Concomitant with the increase in miR-200b and miR-200c ZEB1 expression was decreased and cells appeared more epithelial in morphology and were sensitized to TAM and fulvestrant inhibition;Nintedanib was able to reverse TGF-β1-induced EMT and resistance to gefitinib caused by miR-200b and miR-141 upregulation and ZEB1 downregulation;MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways cell migration;;;;;tumorigenesis;;;;;;;metastasis;;;drug resistance;metastasis gastric cancer;sarcoma;breast cancer;endometrial cancer;sarcoma;head and neck cancer;bladder cancer;breast cancer;ovarian cancer;ovarian cancer;B cell lymphoma;sarcoma;colorectal cancer;prostate cancer;breast cancer;lung squamous cell cancer;breast cancer hsa-miR-200a-3p ZEB2 6.336081120041 4.024313571871e-16 -2.47282736566539 5.20852277574619e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.338263275620555 9.04677621284607e-17 24518294;19787069;24815002;24424572;19854497;21529905;19544444;25797260 This switch involved activation of the transforming growth factor-β TGFβ signaling network that led to a shift in the balance between miR-200 microRNAs and the transcription factor zinc finger E-box-binding homeobox 2 ZEB2 resulting in suppressed transcription of the gene encoding E-cadherin;These findings are surprising since the miR-200 family was previously shown to promote epithelial characteristics by inhibiting the transcriptional repressor Zeb2 and thereby enhancing E-cadherin expression; Expression of miR-200 which promotes a mesenchymal to epithelial cell transition MET by inhibiting Zeb2 expression unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;MicroRNA 200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E cadherin repressor ZEB2; The 3'-UTR of ZEB2 mRNA a transcriptional repressor of E-cadherin was found to be regulated directly by miR-200a; Our results suggest that loss of expression of miR-200a may play a critical role in the repression of E-cadherin by ZEB2 thereby enhancing migration and invasion in CD133/1+ cells;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;MicroRNA 200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2; Overexpression of miR-200a in SP cells decreased metastasis-related markers and expression of ZEB2; The associations between miR-200a SP cells and ZEB2 were validated in HCC; These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2 ;metastasis;;tumorigenesis;;;;metastasis breast cancer;breast cancer;sarcoma;head and neck cancer;ovarian cancer;ovarian cancer;prostate cancer;liver cancer hsa-miR-200a-5p ZEB2 6.52092140839401 5.73108242597059e-22 -2.47282736566539 5.20852277574619e-05 miRNATAP -0.375619631423095 3.15548708298425e-16 24518294;19787069;24815002;24424572;19854497;21529905;19544444;25797260 This switch involved activation of the transforming growth factor-β TGFβ signaling network that led to a shift in the balance between miR-200 microRNAs and the transcription factor zinc finger E-box-binding homeobox 2 ZEB2 resulting in suppressed transcription of the gene encoding E-cadherin;These findings are surprising since the miR-200 family was previously shown to promote epithelial characteristics by inhibiting the transcriptional repressor Zeb2 and thereby enhancing E-cadherin expression; Expression of miR-200 which promotes a mesenchymal to epithelial cell transition MET by inhibiting Zeb2 expression unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;MicroRNA 200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E cadherin repressor ZEB2; The 3'-UTR of ZEB2 mRNA a transcriptional repressor of E-cadherin was found to be regulated directly by miR-200a; Our results suggest that loss of expression of miR-200a may play a critical role in the repression of E-cadherin by ZEB2 thereby enhancing migration and invasion in CD133/1+ cells;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;MicroRNA 200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2; Overexpression of miR-200a in SP cells decreased metastasis-related markers and expression of ZEB2; The associations between miR-200a SP cells and ZEB2 were validated in HCC; These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2 ;metastasis;;tumorigenesis;;;;metastasis breast cancer;breast cancer;sarcoma;head and neck cancer;ovarian cancer;ovarian cancer;prostate cancer;liver cancer hsa-miR-200b-3p ZEB2 5.56167217794639 6.43540045061709e-16 -2.47282736566539 5.20852277574619e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.381732562017253 1.28505144812548e-16 24518294;19787069;24815002;24424572;24769353;19854497;22311119;19544444 This switch involved activation of the transforming growth factor-β TGFβ signaling network that led to a shift in the balance between miR-200 microRNAs and the transcription factor zinc finger E-box-binding homeobox 2 ZEB2 resulting in suppressed transcription of the gene encoding E-cadherin;These findings are surprising since the miR-200 family was previously shown to promote epithelial characteristics by inhibiting the transcriptional repressor Zeb2 and thereby enhancing E-cadherin expression; Expression of miR-200 which promotes a mesenchymal to epithelial cell transition MET by inhibiting Zeb2 expression unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;Zinc finger E box binding homeobox 2 ZEB2 regulated by miR 200b contributes to multi drug resistance of small cell lung cancer; In silico analysis demonstrated that there are complementary binding sites between miR-200b and ZEB2 3'-UTR and identified miR-200b as a potential regulator of ZEB2; Overexpression of miR-200b led to the downregulation of ZEB2 at protein level; Luciferase reporter gene assay showed that 3'UTR ZEB2 activity was regulated by miR-200b; Our results suggest that ZEB2 modulates drug resistance and is regulated by miR-200b;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;MicroRNA 200b regulates cell proliferation invasion and migration by directly targeting ZEB2 in gastric carcinoma; There was a strong correlation between the levels of miR-200b and ZEB2 and E-cadherin mRNAs in gastric cancer patients; miR-200b regulates ZEB2 expression and thus controls metastasis in gastric cancer;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2 ;metastasis;;tumorigenesis;drug resistance;;metastasis; breast cancer;breast cancer;sarcoma;head and neck cancer;lung squamous cell cancer;ovarian cancer;gastric cancer;prostate cancer hsa-miR-200a-3p ZFP37 6.336081120041 4.024313571871e-16 -1.78486478009201 0.0653728388530415 mirMAP -0.175234435347959 0.00903446464736174 NA NA NA hsa-miR-200a-3p ZFPM2 6.336081120041 4.024313571871e-16 -4.98416670049111 3.64077996689347e-05 miRNAWalker2_validate;miRTarBase -0.28975981860095 0.000583132762227317 26314828 It was reported that miR-200 can activate PI3K/AKT by targeting FOG2 friend of GATA 2 which directly binds to the p85α regulatory subunit of PI3K lung cancer hsa-miR-200b-3p ZFPM2 5.56167217794639 6.43540045061709e-16 -4.98416670049111 3.64077996689347e-05 miRNAWalker2_validate;miRTarBase;TargetScan -0.241699147846238 0.0117496222359349 26314828 It was reported that miR-200 can activate PI3K/AKT by targeting FOG2 friend of GATA 2 which directly binds to the p85α regulatory subunit of PI3K lung cancer hsa-miR-200a-3p ZIK1 6.336081120041 4.024313571871e-16 -3.1474919145676 0.000131796457800744 mirMAP -0.23763409937942 3.12292863967608e-05 NA NA NA hsa-miR-200b-3p ZNF365 5.56167217794639 6.43540045061709e-16 2.61048595110261 0.0369632440092293 TargetScan -0.271650709133046 0.00573551454679111 NA NA NA hsa-miR-200a-5p ZNF471 6.52092140839401 5.73108242597059e-22 -4.14744282174933 0.00115251146316353 mirMAP -0.20860080797468 0.038128126545149 NA NA NA hsa-miR-200b-5p ZNF471 6.81954246537908 6.31100593281326e-24 -4.14744282174933 0.00115251146316353 mirMAP -0.208506546741814 0.0371176401930054 NA NA NA hsa-miR-200b-3p ZNF532 5.56167217794639 6.43540045061709e-16 -0.649960825484786 0.183521921069682 MirTarget;TargetScan -0.19512161011849 2.17242538128109e-07 NA NA NA hsa-miR-200a-5p ZNF677 6.52092140839401 5.73108242597059e-22 -4.79251223609332 1.25094415856671e-06 mirMAP -0.37699130814728 1.15549122946662e-06 NA NA NA hsa-miR-200b-5p ZNF677 6.81954246537908 6.31100593281326e-24 -4.79251223609332 1.25094415856671e-06 mirMAP -0.367901596188841 1.84645736897831e-06 NA NA NA hsa-miR-200b-3p ZNF697 5.56167217794639 6.43540045061709e-16 0.50797212985108 0.348570189924842 TargetScan -0.101978531581088 0.0162888847979391 NA NA NA hsa-miR-200b-3p ZNF772 5.56167217794639 6.43540045061709e-16 -2.60657405066085 0.0328229507958995 mirMAP -0.38088231859159 6.47305098428849e-05 NA NA NA hsa-miR-200a-5p ZNF788 6.52092140839401 5.73108242597059e-22 -3.01335283274138 0.002017254082973 mirMAP -0.315017229276109 3.44959905065908e-05 NA NA NA hsa-miR-200b-5p ZNF788 6.81954246537908 6.31100593281326e-24 -3.01335283274138 0.002017254082973 mirMAP -0.314808436680268 3.13983225174926e-05 NA NA NA hsa-miR-200a-5p ZNF85 6.52092140839401 5.73108242597059e-22 -1.85078304811064 0.0725739724463506 MirTarget -0.267233765691857 0.000878849991485781 NA NA NA hsa-miR-200b-5p ZNF85 6.81954246537908 6.31100593281326e-24 -1.85078304811064 0.0725739724463506 MirTarget -0.249423722558606 0.0018125066503293 NA NA NA hsa-miR-200a-3p ZSCAN23 6.336081120041 4.024313571871e-16 -1.73014178283799 0.220509336460992 miRNATAP -0.224539113411533 0.0217720534964273 NA NA NA