miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p APC2 -1.37014061604018 3.11451492971224e-14 1.13734300868111 0.000124925970306742 TargetScan -0.464919515060219 2.14185938273543e-10 NA NA NA hsa-miR-15b-3p CAMK2A 0.804736041893915 0.000400279611457186 -1.98450244020379 1.79267707874172e-10 mirMAP -0.328424579288596 9.92187913064475e-07 NA NA NA hsa-miR-19b-1-5p CAMK2A 1.71217036351784 3.28561659177495e-12 -1.98450244020379 1.79267707874172e-10 mirMAP -0.342392712947742 2.74781586124706e-07 NA NA NA hsa-miR-21-3p CAMK2A 2.54206008030157 1.11598785398763e-30 -1.98450244020379 1.79267707874172e-10 MirTarget -0.324653187186303 1.25884069603633e-07 NA NA NA hsa-miR-25-3p CAMK2A 0.361927330834176 0.0163670566170988 -1.98450244020379 1.79267707874172e-10 MirTarget -0.431018251677991 9.57991045458072e-06 NA NA NA hsa-miR-7-1-3p CAMK2A 2.61364240402652 1.98959237815786e-32 -1.98450244020379 1.79267707874172e-10 MirTarget -0.321459504611602 6.82264507997045e-07 NA NA NA hsa-miR-29a-3p CAMK2B 0.101650412194573 0.573201097011668 1.36872036948597 0.01479821016335 mirMAP -0.56719932512718 8.45582460317295e-05 NA NA NA hsa-miR-15b-5p CCND1 -1.25935038177398 1.83460220856901e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.303824360423629 3.25741318048184e-06 NA NA NA hsa-miR-16-5p CCND1 0.749619098384047 4.11649450706988e-06 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.371885624299403 3.21606546730418e-07 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-17-5p CCND1 2.07078488653279 2.77403038572568e-19 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.313758634258834 1.59321495552009e-10 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-186-5p CCND1 0.852175445703945 6.88885738584309e-10 -0.295767629587253 0.255400743295204 mirMAP -0.377477028673122 1.06268066352005e-05 NA NA NA hsa-miR-19b-1-5p CCND1 1.71217036351784 3.28561659177495e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase -0.301713494105536 2.89182846291565e-08 NA NA NA hsa-miR-374a-5p CCND1 -0.197027254874826 0.298080902192861 -0.295767629587253 0.255400743295204 MirTarget -0.313785702713176 9.54081268797886e-06 27191497 microRNA 374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway; Furthermore luciferase reporter assays confirmed that miR-374a could directly reduce CCND1; We examined miR-374a levels by in situ hybridization and its correlation with CCND1 expression in CRC tumor tissues; High miR-374a expression with low level of CCND1 was protective factor in CRC; Together these findings indicate that miR-374a inactivates the PI3K/AKT axis by inhibiting CCND1 suppressing of colon cancer progression progression colon cancer hsa-miR-92a-3p CCND1 -0.136362762339122 0.493412263619364 -0.295767629587253 0.255400743295204 miRNAWalker2_validate -0.337251172229938 1.62058605849004e-08 NA NA NA hsa-miR-93-5p CCND1 1.50844106515467 1.83836866996875e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget;miRNATAP -0.320397820083252 2.84014735439528e-09 NA NA NA hsa-miR-106b-5p CCND2 1.47447672652218 1.32004094930462e-13 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.383655587509124 2.65429916887189e-13 NA NA NA hsa-miR-17-5p CCND2 2.07078488653279 2.77403038572568e-19 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.365048259055278 1.61934056872758e-16 NA NA NA hsa-miR-182-5p CCND2 3.21839823004635 5.13049145201115e-39 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.373145719566719 1.32597677460149e-21 NA NA NA hsa-miR-183-5p CCND2 2.39247234736657 3.92444525331999e-21 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.410520271082553 1.11291256348519e-25 NA NA NA hsa-miR-186-5p CCND2 0.852175445703945 6.88885738584309e-10 -1.64140990579885 1.49666938681079e-12 mirMAP;miRNATAP -0.357370184588874 5.14493635358813e-06 NA NA NA hsa-miR-93-5p CCND2 1.50844106515467 1.83836866996875e-12 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.414585687663892 1.04746846150745e-17 NA NA NA hsa-miR-96-5p CCND2 3.0381097138467 4.40362891630201e-24 -1.64140990579885 1.49666938681079e-12 TargetScan;miRNATAP -0.357833634781266 1.13611538125112e-20 NA NA NA hsa-miR-146a-5p CXXC4 0.684701497250824 0.0105316554224149 0.0566167029048437 0.898573597373873 MirTarget -0.350377108448351 6.59996056360575e-06 NA NA NA hsa-miR-146b-5p CXXC4 1.0922867893808 5.63754607494775e-06 0.0566167029048437 0.898573597373873 MirTarget;miRNATAP -0.464894280317033 2.37210568003522e-08 NA NA NA hsa-miR-193a-3p DAAM2 0.549173467360291 0.0319030569365466 -1.63575002900602 1.24411166382277e-06 miRanda -0.317681153766389 1.56668678202965e-06 NA NA NA hsa-miR-421 DAAM2 0.170525317701774 0.535277026680289 -1.63575002900602 1.24411166382277e-06 PITA;miRanda -0.387712827165418 2.29641218162031e-10 NA NA NA hsa-miR-590-3p DAAM2 0.83851360565783 0.00129224433453587 -1.63575002900602 1.24411166382277e-06 miRanda;mirMAP -0.390226552899291 4.51082807556656e-08 NA NA NA hsa-miR-324-5p DKK2 1.06955541886548 5.39722006604758e-05 -2.4633236718169 1.11856969198376e-14 miRanda -0.321969995987594 9.18543779254221e-09 NA NA NA hsa-miR-590-5p DKK2 2.07441240363458 4.95240551694843e-14 -2.4633236718169 1.11856969198376e-14 miRanda -0.428331735408766 5.06502656501701e-11 NA NA NA hsa-miR-429 FOSL1 2.3794516574089 1.72813419703734e-13 -0.165525066118656 0.701922388976116 miRanda;miRNATAP -0.302054339689753 2.8810504206678e-06 NA NA NA hsa-miR-186-5p FZD1 0.852175445703945 6.88885738584309e-10 -0.364780801849827 0.099789866871212 mirMAP -0.332559523219329 5.26187654799382e-06 NA NA NA hsa-miR-23a-3p FZD3 0.111958289789488 0.393086414480463 0.792931453624831 0.000876919876092158 MirTarget -0.347104426876378 4.62727121014698e-05 NA NA NA hsa-miR-361-5p FZD3 0.21454431962475 0.0800957579368424 0.792931453624831 0.000876919876092158 miRanda;miRNATAP -0.342058727896923 0.000182482143740012 NA NA NA hsa-miR-130b-3p MAPK10 1.83046548750752 5.04753914574694e-13 -1.84555409354538 2.44653235090281e-07 miRNATAP -0.537034366335229 2.86966630336949e-16 NA NA NA hsa-miR-590-3p MAPK10 0.83851360565783 0.00129224433453587 -1.84555409354538 2.44653235090281e-07 miRanda;mirMAP -0.487483452887983 9.33422066806689e-11 NA NA NA hsa-miR-590-5p MAPK10 2.07441240363458 4.95240551694843e-14 -1.84555409354538 2.44653235090281e-07 PITA;miRanda;miRNATAP -0.563200566282606 2.40959066969729e-15 NA NA NA hsa-miR-185-5p NFATC2 1.14291034858482 2.95777119743491e-13 -1.17929519652878 0.000402858371584528 MirTarget -0.360674698099435 0.00018867412489729 NA NA NA hsa-miR-186-5p NFATC2 0.852175445703945 6.88885738584309e-10 -1.17929519652878 0.000402858371584528 mirMAP -0.343079979359603 0.00202223937894896 NA NA NA hsa-miR-19a-3p NFATC2 2.11776595911517 7.07663078397156e-10 -1.17929519652878 0.000402858371584528 mirMAP -0.336569537886002 7.83772096103092e-11 NA NA NA hsa-miR-19b-3p NFATC2 2.10868505662119 5.40846613768389e-17 -1.17929519652878 0.000402858371584528 mirMAP -0.37856857138205 7.5498987798628e-10 NA NA NA hsa-miR-21-5p NKD1 4.38165933891779 1.52536633902505e-92 -1.734580414771 4.24665289948679e-06 mirMAP -0.393412938012472 2.27374130691586e-09 NA NA NA hsa-miR-140-3p PLCB1 -1.11373309124537 8.35257079443689e-14 0.158764231657558 0.604491663416039 PITA -0.394399576367962 1.98980424060224e-05 NA NA NA hsa-miR-183-5p PLCB4 2.39247234736657 3.92444525331999e-21 -1.82668492890878 7.15026249037583e-05 miRNATAP -0.32327679918221 5.55690039859461e-05 NA NA NA hsa-miR-590-3p PLCB4 0.83851360565783 0.00129224433453587 -1.82668492890878 7.15026249037583e-05 miRanda -0.349124663122461 0.000356727663520599 NA NA NA hsa-miR-96-5p PLCB4 3.0381097138467 4.40362891630201e-24 -1.82668492890878 7.15026249037583e-05 TargetScan;miRNATAP -0.312602828639921 5.66117781357207e-05 NA NA NA hsa-miR-141-3p PRICKLE1 3.36993755486106 5.42939251147195e-32 -1.65089034062227 4.19267321353062e-10 TargetScan -0.346500597753672 5.2847980672073e-19 NA NA NA hsa-miR-17-5p PRICKLE1 2.07078488653279 2.77403038572568e-19 -1.65089034062227 4.19267321353062e-10 miRNAWalker2_validate -0.366267721871006 4.31066943515129e-13 NA NA NA hsa-miR-148b-3p PRICKLE2 0.483970528590224 0.0026495409465901 -1.56077600074788 2.11863685620441e-14 MirTarget;miRNATAP -0.345800929865677 6.84481017225917e-09 NA NA NA hsa-miR-590-5p PRICKLE2 2.07441240363458 4.95240551694843e-14 -1.56077600074788 2.11863685620441e-14 MirTarget;PITA;miRanda -0.343045860860681 7.2266426394492e-17 NA NA NA hsa-miR-181c-5p PRKCA 0.529875814537156 0.0125885822998008 -0.189679589892687 0.471078192212991 mirMAP -0.326745565499583 6.66432412436314e-09 NA NA NA hsa-miR-2110 PRKCG -1.92124860612475 1.1464887721828e-12 1.66883505426905 0.000268885102920086 MirTarget -0.307845409938279 6.49952836801256e-05 NA NA NA hsa-miR-30c-2-3p RAC3 -3.10905250533941 6.84550165664783e-27 1.82835649257478 3.33704760151114e-09 miRNAWalker2_validate -0.370936437115312 5.24524075378395e-16 NA NA NA hsa-miR-146b-5p SFRP1 1.0922867893808 5.63754607494775e-06 -2.08752885738513 5.38679141051593e-05 MirTarget -0.52942072100834 6.32795389015505e-08 NA NA NA hsa-miR-16-1-3p SFRP1 1.50034693398929 6.63958242991125e-10 -2.08752885738513 5.38679141051593e-05 MirTarget -0.484182161826445 5.65968227514651e-05 NA NA NA hsa-miR-29a-5p SFRP1 1.89519956688438 1.03453349363915e-11 -2.08752885738513 5.38679141051593e-05 mirMAP -0.549369602929202 3.46808310125807e-08 NA NA NA hsa-miR-96-5p SFRP1 3.0381097138467 4.40362891630201e-24 -2.08752885738513 5.38679141051593e-05 mirMAP -0.377228057292009 1.50643419827674e-05 NA NA NA hsa-miR-26b-5p SFRP4 0.72362441215247 4.7794659748036e-05 0.502900557158704 0.215273865000971 miRNAWalker2_validate -0.306869750257348 0.00345714161336382 NA NA NA hsa-miR-127-5p WIF1 2.05164948368907 3.61318574536718e-09 -5.68437329541209 2.64369382414593e-13 PITA;miRNATAP -0.491614161322484 1.88198280801827e-06 NA NA NA hsa-miR-28-5p WIF1 1.19639196514745 4.59365801666536e-18 -5.68437329541209 2.64369382414593e-13 miRanda -0.751184363123977 0.00387124533394718 NA NA NA hsa-miR-590-3p WIF1 0.83851360565783 0.00129224433453587 -5.68437329541209 2.64369382414593e-13 PITA;miRanda;mirMAP -0.522932753335165 0.00196303246166186 NA NA NA hsa-miR-590-3p WNT11 0.83851360565783 0.00129224433453587 -2.02143786067022 1.52557188447296e-07 miRanda -0.373242513422953 5.34584852988355e-06 NA NA NA hsa-miR-181a-5p WNT16 -0.375429731222937 0.0562142867129802 0.421312581058213 0.381219057601469 miRNAWalker2_validate;MirTarget -0.418738717276526 0.000206105344005426 NA NA NA hsa-miR-181b-5p WNT16 0.668793269169928 0.000239998092406404 0.421312581058213 0.381219057601469 MirTarget -0.40294447968335 0.000916083429841582 NA NA NA hsa-miR-335-3p WNT2 1.51116383169018 6.88553098788624e-13 -1.62099341554492 1.02036799041017e-06 mirMAP -0.424763785809356 1.9482456471186e-09 NA NA NA hsa-miR-130b-3p WNT2B 1.83046548750752 5.04753914574694e-13 -1.78890659702403 3.23609097451353e-13 MirTarget -0.340760827768826 1.27877889985709e-13 NA NA NA hsa-miR-107 WNT3A 0.658676029898313 5.11480446318819e-07 -5.44957058224664 2.48610908209879e-25 MirTarget;PITA;miRanda;miRNATAP -0.602191379255807 0.00204464357053535 NA NA NA hsa-miR-128-3p WNT3A 1.03509868349735 2.11606310588315e-10 -5.44957058224664 2.48610908209879e-25 miRNAWalker2_validate -0.728776208229076 2.12961409810896e-06 27341528 AurkA controls self renewal of breast cancer initiating cells promoting wnt3a stabilization through suppression of miR 128; Interestingly we found that AurkA suppressed the expression of miR-128 inhibitor of wnt3a mRNA stabilization breast cancer hsa-miR-16-2-3p WNT5A 0.503964803530872 0.0263648405197492 -0.372121221213175 0.193057277928512 MirTarget;mirMAP -0.373377688750202 1.87980527171712e-09 NA NA NA hsa-miR-186-5p WNT5A 0.852175445703945 6.88885738584309e-10 -0.372121221213175 0.193057277928512 miRNAWalker2_validate;mirMAP;miRNATAP -0.417054301807237 9.65966030008268e-06 NA NA NA hsa-miR-576-5p WNT5A 1.02693643167056 1.14846964470173e-06 -0.372121221213175 0.193057277928512 mirMAP -0.395707662531266 7.42053392121266e-11 NA NA NA hsa-miR-92a-3p WNT5A -0.136362762339122 0.493412263619364 -0.372121221213175 0.193057277928512 miRNAWalker2_validate -0.355450854560077 6.47407085500391e-08 NA NA NA hsa-miR-107 WNT7A 0.658676029898313 5.11480446318819e-07 -4.45137691541241 9.35879470799359e-12 MirTarget;miRanda -1.03715758348073 9.71742260378246e-06 NA NA NA hsa-miR-16-5p WNT7A 0.749619098384047 4.11649450706988e-06 -4.45137691541241 9.35879470799359e-12 MirTarget -0.548666659996717 0.00371402269827223 NA NA NA hsa-miR-28-5p WNT9A 1.19639196514745 4.59365801666536e-18 -1.70715193650801 1.03413487994031e-08 mirMAP -0.413487846679742 2.50403745773092e-05 NA NA NA