miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-195-5p ABHD13 -1.07154705036962 4.16544134775761e-08 0.111646009137421 0.215616234299558 MirTarget;miRNATAP -0.138532170686329 2.64201202839037e-07 NA NA NA hsa-miR-195-5p ABL2 -1.07154705036962 4.16544134775761e-08 0.820053510414726 8.89463322803119e-15 MirTarget;miRNATAP -0.125510071317435 0.000207720682615577 NA NA NA hsa-miR-195-5p ACTR2 -1.07154705036962 4.16544134775761e-08 0.337308568859711 1.76085459344764e-05 MirTarget;miRNATAP -0.166399210993874 7.82147950805178e-13 NA NA NA hsa-miR-195-5p ACVR2B -1.07154705036962 4.16544134775761e-08 0.479263794953631 0.00365312140717121 miRNATAP -0.252008589401995 4.40234728248203e-07 NA NA NA hsa-miR-195-5p AEBP2 -1.07154705036962 4.16544134775761e-08 0.252772237125885 0.016489185847765 MirTarget -0.19036564353782 1.28243712253807e-09 NA NA NA hsa-miR-195-5p AKAP11 -1.07154705036962 4.16544134775761e-08 0.196284041245934 0.098252789597144 MirTarget;miRNATAP -0.129829043925349 0.000318659367123983 NA NA NA hsa-miR-195-5p AMMECR1 -1.07154705036962 4.16544134775761e-08 0.664690449964854 8.21999953261348e-07 miRNATAP -0.218366053013071 1.20976436084194e-07 NA NA NA hsa-miR-195-5p AMMECR1L -1.07154705036962 4.16544134775761e-08 0.230914162865004 0.000583289402699861 MirTarget -0.128230606134697 9.61654952248744e-11 NA NA NA hsa-miR-195-5p ANKIB1 -1.07154705036962 4.16544134775761e-08 0.550724165092129 6.52824879558718e-06 miRNATAP -0.234285500509876 1.89428252668118e-10 NA NA NA hsa-miR-195-5p ANKRD13B -1.07154705036962 4.16544134775761e-08 1.4139105364615 1.2609408926851e-14 miRNATAP -0.36695439810533 1.61207495898112e-10 NA NA NA hsa-miR-195-5p APLN -1.07154705036962 4.16544134775761e-08 2.4883990118052 2.03812833840473e-14 MirTarget;miRNATAP -0.48255367332228 3.26646228559259e-06 NA NA NA hsa-miR-195-5p ARHGAP12 -1.07154705036962 4.16544134775761e-08 0.299443745620694 0.017335856466849 miRNATAP -0.225735532508425 1.80884166030312e-09 NA NA NA hsa-miR-195-5p ARHGAP19 -1.07154705036962 4.16544134775761e-08 0.256848148699886 0.0207956245532423 MirTarget;mirMAP -0.142391457672004 2.33196558748147e-05 NA NA NA hsa-miR-195-5p ARHGAP32 -1.07154705036962 4.16544134775761e-08 0.0314712901967784 0.843467188573228 MirTarget -0.225414476909912 2.64334072042196e-06 NA NA NA hsa-miR-195-5p ARHGAP5 -1.07154705036962 4.16544134775761e-08 -0.123874599542773 0.263036005478456 MirTarget;miRNATAP -0.173230224066489 1.6616163161827e-07 NA NA NA hsa-miR-195-5p ARHGEF12 -1.07154705036962 4.16544134775761e-08 0.0895782409826751 0.356931527604922 MirTarget -0.123608813822374 2.42556589131755e-05 NA NA NA hsa-miR-195-5p ARIH1 -1.07154705036962 4.16544134775761e-08 0.0230997107313007 0.793468726040202 MirTarget -0.127071805286041 1.44430630461102e-06 NA NA NA hsa-miR-195-5p ARL8B -1.07154705036962 4.16544134775761e-08 -0.208090655274296 0.0111650980017705 MirTarget;miRNATAP -0.106126143038114 1.78366859188691e-05 NA NA NA hsa-miR-195-5p ATF6 -1.07154705036962 4.16544134775761e-08 0.225879927123844 0.000459541331685973 MirTarget -0.117152564363136 8.26936604253598e-10 NA NA NA hsa-miR-195-5p ATG14 -1.07154705036962 4.16544134775761e-08 0.00414748208186211 0.968361225112142 MirTarget;miRNATAP -0.114348373344435 0.000300840427339442 NA NA NA hsa-miR-195-5p ATP13A3 -1.07154705036962 4.16544134775761e-08 0.926081650501084 4.0761453022813e-13 MirTarget;miRNATAP -0.328179916765787 1.48566430947934e-17 NA NA NA hsa-miR-195-5p ATP2A2 -1.07154705036962 4.16544134775761e-08 0.603549132799283 1.53017817241094e-10 miRNATAP -0.197496950290298 5.61494747297142e-12 NA NA NA hsa-miR-195-5p ATXN2 -1.07154705036962 4.16544134775761e-08 0.266571196061886 0.000720671732750195 MirTarget;miRNATAP -0.125680023479516 1.07401053369451e-07 NA NA NA hsa-miR-195-5p AVL9 -1.07154705036962 4.16544134775761e-08 0.606669599215707 1.98983102053768e-07 MirTarget;miRNATAP -0.267350912989796 1.38432917874768e-14 NA NA NA hsa-miR-195-5p BAG4 -1.07154705036962 4.16544134775761e-08 0.628216551779521 1.21454572492289e-07 MirTarget -0.278941974297103 2.63729084235673e-15 NA NA NA hsa-miR-195-5p BAZ2A -1.07154705036962 4.16544134775761e-08 0.169659176640358 0.0278304123951737 miRNATAP -0.104991412685659 5.74864565682499e-06 NA NA NA hsa-miR-195-5p BCL2L11 -1.07154705036962 4.16544134775761e-08 0.413923585963092 0.000434820349815219 miRNAWalker2_validate -0.134807821070255 0.000183366667864393 NA NA NA hsa-miR-195-5p BPTF -1.07154705036962 4.16544134775761e-08 0.299606256231671 0.000226392203192373 miRNATAP -0.104146475396946 2.45337822849184e-05 NA NA NA hsa-miR-195-5p BRWD3 -1.07154705036962 4.16544134775761e-08 0.357135035895793 0.00225558092998227 MirTarget -0.16036833367404 6.22634972711869e-06 NA NA NA hsa-miR-195-5p BTAF1 -1.07154705036962 4.16544134775761e-08 0.284595286784092 0.0159575202242037 MirTarget -0.22330349679466 1.90821448877469e-10 NA NA NA hsa-miR-195-5p BTBD19 -1.07154705036962 4.16544134775761e-08 0.961835296568945 1.05703169179008e-07 mirMAP -0.13174467660156 0.0205202049512033 NA NA NA hsa-miR-195-5p BZW1 -1.07154705036962 4.16544134775761e-08 0.223899531157188 0.0137384203810424 MirTarget -0.175913529332801 5.50628389787134e-11 NA NA NA hsa-miR-195-5p C6orf223 -1.07154705036962 4.16544134775761e-08 2.65773796576606 1.23932823634783e-08 mirMAP -0.775935654235103 7.57216196677248e-08 NA NA NA hsa-miR-195-5p CAAP1 -1.07154705036962 4.16544134775761e-08 0.0590117435526958 0.658112282478874 MirTarget -0.177262021328013 1.04286741568017e-05 NA NA NA hsa-miR-195-5p CABLES2 -1.07154705036962 4.16544134775761e-08 0.478840442173734 0.00206850227794412 MirTarget -0.122398097965156 0.0106495404541822 NA NA NA hsa-miR-195-5p CAMSAP1 -1.07154705036962 4.16544134775761e-08 0.244651879709817 0.0399081942272141 MirTarget;miRNATAP -0.182933011105944 3.17641891789514e-07 NA NA NA hsa-miR-195-5p CAMSAP2 -1.07154705036962 4.16544134775761e-08 0.423832054082736 0.000532909035924399 miRNATAP -0.162842457712443 1.26708786461718e-05 NA NA NA hsa-miR-195-5p CAND1 -1.07154705036962 4.16544134775761e-08 0.404447093370241 0.000129508898109157 miRNAWalker2_validate -0.235601237423065 3.66753860690047e-14 NA NA NA hsa-miR-195-5p CAPRIN1 -1.07154705036962 4.16544134775761e-08 0.501178219107264 1.17721317713917e-08 MirTarget -0.22764827806576 9.49665394295247e-19 NA NA NA hsa-miR-195-5p CARD10 -1.07154705036962 4.16544134775761e-08 0.69759286086003 6.32305635247415e-06 MirTarget;miRNATAP -0.111036005039936 0.0211691072773329 24787958 MicroRNA 195 inhibits colorectal cancer cell proliferation colony formation and invasion through targeting CARMA3 colorectal cancer hsa-miR-195-5p CASK -1.07154705036962 4.16544134775761e-08 0.893258002519737 2.03825794521693e-11 MirTarget;miRNATAP -0.244376427131361 3.27711863403535e-09 NA NA NA hsa-miR-195-5p CASKIN1 -1.07154705036962 4.16544134775761e-08 0.27486900739404 0.00868555620185409 miRNATAP -0.114316215499989 0.00033978394047703 NA NA NA hsa-miR-195-5p CCDC18 -1.07154705036962 4.16544134775761e-08 0.998176470669342 2.76320617868319e-12 MirTarget -0.284551598640539 1.18614871527828e-10 NA NA NA hsa-miR-195-5p CCDC6 -1.07154705036962 4.16544134775761e-08 0.270451325546948 0.0255492648029981 MirTarget;miRNATAP -0.252824424331261 1.26007348127646e-12 NA NA NA hsa-miR-195-5p CCND1 -1.07154705036962 4.16544134775761e-08 0.720140419027159 0.000259727836476946 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.270917365501396 6.99604795762646e-06 21350001;26631043;25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma ;;metastasis;poor survival breast cancer;cervical and endocervical cancer;sarcoma hsa-miR-195-5p CCNE1 -1.07154705036962 4.16544134775761e-08 1.63902722877652 2.5095106440044e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.508445516091264 1.96888625792722e-08 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-195-5p CCNJ -1.07154705036962 4.16544134775761e-08 0.913730637323214 4.91886549059683e-14 miRNATAP -0.30282756015363 2.07186227821141e-16 NA NA NA hsa-miR-195-5p CCNT1 -1.07154705036962 4.16544134775761e-08 0.264319239474542 0.00380801495524941 MirTarget;miRNATAP -0.187919453522015 2.76375476597245e-12 NA NA NA hsa-miR-195-5p CCNT2 -1.07154705036962 4.16544134775761e-08 0.201550620087344 0.0335260688822665 MirTarget;miRNATAP -0.180109739230476 1.2884226411047e-10 NA NA NA hsa-miR-195-5p CD164 -1.07154705036962 4.16544134775761e-08 0.000333198612235464 0.997584139980248 MirTarget;miRNATAP -0.139402952002985 2.63794929870953e-05 NA NA NA hsa-miR-195-5p CD274 -1.07154705036962 4.16544134775761e-08 0.396416404451936 0.124310980861393 MirTarget -0.197949802798256 0.0123843464003013 NA NA NA hsa-miR-195-5p CD276 -1.07154705036962 4.16544134775761e-08 0.968051106476798 2.11777523738325e-12 mirMAP -0.103362723463784 0.0190650364141054 NA NA NA hsa-miR-195-5p CD2AP -1.07154705036962 4.16544134775761e-08 0.31650568123867 0.0300513622172675 miRNATAP -0.292265364557668 1.23786169025738e-11 NA NA NA hsa-miR-195-5p CD47 -1.07154705036962 4.16544134775761e-08 0.385536246805254 0.000581527474684262 MirTarget -0.142188095140055 3.18725789813318e-05 NA NA NA hsa-miR-195-5p CD80 -1.07154705036962 4.16544134775761e-08 1.61896517280609 2.07127459473612e-11 MirTarget -0.228113038025483 0.00303015929961089 NA NA NA hsa-miR-195-5p CDC25A -1.07154705036962 4.16544134775761e-08 1.56346598354421 9.99488105357483e-12 MirTarget;miRNATAP -0.432239380619452 1.37481779283584e-09 NA NA NA hsa-miR-195-5p CDC27 -1.07154705036962 4.16544134775761e-08 0.384273651115161 2.02443424744725e-06 miRNATAP -0.216561688967975 1.27012292328695e-20 NA NA NA hsa-miR-195-5p CDCA4 -1.07154705036962 4.16544134775761e-08 0.805531038478369 2.51141993478122e-08 miRNATAP -0.234017183583385 1.50791091114834e-07 NA NA NA hsa-miR-195-5p CDK6 -1.07154705036962 4.16544134775761e-08 0.990643124320291 1.17862667832619e-06 miRNAWalker2_validate;miRTarBase -0.290091435905514 3.96478737812371e-06 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-195-5p CEP350 -1.07154705036962 4.16544134775761e-08 0.0262733778281072 0.780310863214028 miRNATAP -0.1380588886792 9.49561476493436e-07 NA NA NA hsa-miR-195-5p CEP55 -1.07154705036962 4.16544134775761e-08 2.5148378909789 3.65565875649058e-24 MirTarget -0.51238609278226 2.28842875730949e-10 NA NA NA hsa-miR-195-5p CHEK1 -1.07154705036962 4.16544134775761e-08 1.31371493705371 1.44136781815912e-17 MirTarget;miRNATAP -0.398348011078744 4.46376910732843e-17 25840419 MiR 195 suppresses non small cell lung cancer by targeting CHEK1; We discovered that CHEK1 was a direct target of miR-195 which decreased CHEK1 expression in lung cancer cells lung squamous cell cancer hsa-miR-195-5p CHORDC1 -1.07154705036962 4.16544134775761e-08 0.884414827032544 5.03065059921512e-11 MirTarget -0.329579822368771 3.83131475012133e-16 NA NA NA hsa-miR-195-5p CHUK -1.07154705036962 4.16544134775761e-08 0.260508655820102 0.00541846716349918 miRNAWalker2_validate;MirTarget -0.209408932879662 1.77454617069446e-14 NA NA NA hsa-miR-195-5p CLCN5 -1.07154705036962 4.16544134775761e-08 1.07858168468305 2.17457193397548e-10 miRNATAP -0.255916320646202 1.43074233777827e-06 NA NA NA hsa-miR-195-5p CLDN12 -1.07154705036962 4.16544134775761e-08 0.538598929103711 0.000332875606087705 MirTarget;miRNATAP -0.358454676072313 3.12356648886872e-16 NA NA NA hsa-miR-195-5p CLSPN -1.07154705036962 4.16544134775761e-08 2.68887335431105 7.67510585936625e-33 MirTarget -0.605901447514368 3.02332306148847e-16 NA NA NA hsa-miR-195-5p CMPK1 -1.07154705036962 4.16544134775761e-08 0.0706622549429428 0.548541383275774 miRNATAP -0.127674483286295 0.000349122274416656 NA NA NA hsa-miR-195-5p COL12A1 -1.07154705036962 4.16544134775761e-08 1.85024755694303 1.80226749421741e-14 MirTarget;miRNATAP -0.320499211625525 3.34045913139535e-05 NA NA NA hsa-miR-195-5p COPB1 -1.07154705036962 4.16544134775761e-08 0.189493260480481 0.0226598567840602 miRNAWalker2_validate -0.159026095448629 8.64434912662813e-11 NA NA NA hsa-miR-195-5p COPS2 -1.07154705036962 4.16544134775761e-08 -0.177690858514008 0.0497397118986118 MirTarget -0.134305386834003 7.50585933548526e-07 NA NA NA hsa-miR-195-5p COX15 -1.07154705036962 4.16544134775761e-08 0.0495310349265212 0.569240469253165 MirTarget -0.138230705308987 9.22787431572923e-08 NA NA NA hsa-miR-195-5p CPD -1.07154705036962 4.16544134775761e-08 0.472292207396693 0.00120847178337317 MirTarget;miRNATAP -0.219546758522048 6.96882859270284e-07 NA NA NA hsa-miR-195-5p CPSF4 -1.07154705036962 4.16544134775761e-08 0.380778995442512 0.000389680481007595 mirMAP -0.103650924442053 0.0016734871856955 NA NA NA hsa-miR-195-5p CPSF6 -1.07154705036962 4.16544134775761e-08 0.470787186015897 2.09257050552201e-10 MirTarget -0.173482319248243 4.467213037872e-15 NA NA NA hsa-miR-195-5p CPSF7 -1.07154705036962 4.16544134775761e-08 0.082550772153672 0.228385100854612 MirTarget;miRNATAP -0.102314516586772 4.92765358234825e-07 NA NA NA hsa-miR-195-5p CRKL -1.07154705036962 4.16544134775761e-08 0.25170209689105 0.00250930892587782 MirTarget;miRNATAP -0.180566662851218 1.21593986589251e-13 NA NA NA hsa-miR-195-5p CSNK1A1 -1.07154705036962 4.16544134775761e-08 -0.18965029227064 0.0168685897975471 mirMAP -0.100275752122776 2.7723963145829e-05 NA NA NA hsa-miR-195-5p CTDSPL -1.07154705036962 4.16544134775761e-08 0.0846519426294803 0.451210027493253 miRNATAP -0.110417600056867 0.00121374056476098 NA NA NA hsa-miR-195-5p CUL2 -1.07154705036962 4.16544134775761e-08 0.196574106706455 0.0126392518992625 MirTarget;miRNATAP -0.130061656249083 3.031362858052e-08 NA NA NA hsa-miR-195-5p DAG1 -1.07154705036962 4.16544134775761e-08 0.43522339920195 0.000267400503627502 mirMAP -0.146392518448236 6.15545645870714e-05 NA NA NA hsa-miR-195-5p DAGLA -1.07154705036962 4.16544134775761e-08 0.857578111812451 2.1301665454655e-06 mirMAP -0.170303348979055 0.00251145252504152 NA NA NA hsa-miR-195-5p DCAF7 -1.07154705036962 4.16544134775761e-08 0.451339851389479 6.91762366196336e-10 miRNATAP -0.10704339792226 2.17692256714813e-06 NA NA NA hsa-miR-195-5p DCUN1D1 -1.07154705036962 4.16544134775761e-08 0.204458301515362 0.0361973837822911 MirTarget -0.238184906577237 2.02678931572238e-17 NA NA NA hsa-miR-195-5p DCUN1D4 -1.07154705036962 4.16544134775761e-08 -0.256427886046376 0.0215922527238607 MirTarget;miRNATAP -0.100911391223795 0.00308720219689782 NA NA NA hsa-miR-195-5p DENND1B -1.07154705036962 4.16544134775761e-08 -0.0294932955092735 0.822568439976429 miRNATAP -0.14603536807918 0.000250098278454954 NA NA NA hsa-miR-195-5p DEPDC5 -1.07154705036962 4.16544134775761e-08 0.116901318901886 0.170429782120094 MirTarget -0.105074470226619 4.25547826063343e-05 NA NA NA hsa-miR-195-5p DIEXF -1.07154705036962 4.16544134775761e-08 0.919369859934161 1.79686114752337e-21 MirTarget -0.241192078961987 1.77225352239988e-15 NA NA NA hsa-miR-195-5p DMTF1 -1.07154705036962 4.16544134775761e-08 0.248049933973103 0.0272588092258348 MirTarget;miRNATAP -0.12301698660683 0.00031975050131128 NA NA NA hsa-miR-195-5p DNAJC25 -1.07154705036962 4.16544134775761e-08 0.0722161041328251 0.413271322510952 MirTarget -0.113394763563898 1.90321726769508e-05 NA NA NA hsa-miR-195-5p DOT1L -1.07154705036962 4.16544134775761e-08 0.31520576355025 0.00906704765553076 mirMAP -0.108826509158397 0.00326613208631977 NA NA NA hsa-miR-195-5p DPY19L4 -1.07154705036962 4.16544134775761e-08 0.487250580443037 5.36176978907663e-06 MirTarget -0.246316428993197 6.69399857303941e-15 NA NA NA hsa-miR-195-5p E2F3 -1.07154705036962 4.16544134775761e-08 1.28918854042277 1.74177583223201e-27 miRNAWalker2_validate;miRTarBase;miRNATAP -0.317627344832083 6.58598738402716e-17 22217655 We identified E2F3 and CCND3 as functional downstream targets of miR-195 in glioblastoma cells glioblastoma hsa-miR-195-5p E2F7 -1.07154705036962 4.16544134775761e-08 2.74390220557803 3.47272604279925e-20 miRNATAP -0.719320287653285 1.99615299114148e-14 NA NA NA hsa-miR-195-5p EGLN1 -1.07154705036962 4.16544134775761e-08 -0.12730652589272 0.153604768279239 MirTarget -0.118248467608134 1.03550696051209e-05 NA NA NA hsa-miR-195-5p EIF3A -1.07154705036962 4.16544134775761e-08 0.315511163695535 0.000119177973319414 MirTarget;miRNATAP -0.166966721304648 5.9860798751073e-12 NA NA NA hsa-miR-195-5p ELAVL1 -1.07154705036962 4.16544134775761e-08 0.339058268147154 3.72619330598869e-06 mirMAP -0.164316082088851 2.48858291988226e-14 NA NA NA hsa-miR-195-5p EPB41L5 -1.07154705036962 4.16544134775761e-08 0.23572912830258 0.0151030868694117 MirTarget -0.160710053941859 2.99469059896119e-08 NA NA NA hsa-miR-195-5p EPG5 -1.07154705036962 4.16544134775761e-08 0.10063742042712 0.35629932320302 mirMAP -0.13225236560767 5.99758765300431e-05 NA NA NA hsa-miR-195-5p ERCC6 -1.07154705036962 4.16544134775761e-08 0.230404587369336 0.0149963112615399 MirTarget -0.160139841756164 1.4700564466917e-08 NA NA NA hsa-miR-195-5p ETNK1 -1.07154705036962 4.16544134775761e-08 0.130493640655022 0.439954851427487 MirTarget -0.27940046665876 3.19425266239961e-08 NA NA NA hsa-miR-195-5p EYA3 -1.07154705036962 4.16544134775761e-08 0.361675436679414 0.000261694774867931 mirMAP -0.184128440665385 5.06169545272878e-10 NA NA NA hsa-miR-195-5p FAM122B -1.07154705036962 4.16544134775761e-08 0.774412494731888 1.23527172218558e-08 MirTarget -0.233609623647198 2.31108076023984e-08 NA NA NA hsa-miR-195-5p FAM133B -1.07154705036962 4.16544134775761e-08 0.457092621148189 0.000942455431724166 MirTarget;miRNATAP -0.239614358628133 8.25286568367998e-09 NA NA NA hsa-miR-195-5p FAM135A -1.07154705036962 4.16544134775761e-08 -0.019634574906318 0.901677506864412 miRNATAP -0.263051248441961 3.00053372307858e-08 NA NA NA hsa-miR-195-5p FAM161A -1.07154705036962 4.16544134775761e-08 0.184954654544411 0.214390035381984 MirTarget -0.195964559091299 1.35328523265492e-05 NA NA NA hsa-miR-195-5p FAM189B -1.07154705036962 4.16544134775761e-08 0.321243563007759 0.000717731870462528 miRNATAP -0.118422429424144 4.18512536494787e-05 NA NA NA hsa-miR-195-5p FAM60A -1.07154705036962 4.16544134775761e-08 1.19356998631741 6.99016629112845e-15 miRNATAP -0.372506738617807 2.37324070955392e-15 NA NA NA hsa-miR-195-5p FAM81A -1.07154705036962 4.16544134775761e-08 1.54366991214478 5.86641461206892e-11 miRNATAP -0.415884838393366 1.40589018742331e-08 NA NA NA hsa-miR-195-5p FAM84B -1.07154705036962 4.16544134775761e-08 0.947290765677161 9.60381545629834e-07 MirTarget -0.274124483426835 4.32467798831073e-06 NA NA NA hsa-miR-195-5p FAM91A1 -1.07154705036962 4.16544134775761e-08 1.06327192404646 3.8051602601026e-18 MirTarget;miRNATAP -0.342367677871589 4.06141953301276e-20 NA NA NA hsa-miR-195-5p FASN -1.07154705036962 4.16544134775761e-08 0.760826973651481 2.66037915989727e-06 MirTarget -0.318304899269464 7.44893085781407e-11 23162665 microRNA 195 suppresses osteosarcoma cell invasion and migration in vitro by targeting FASN; We also identified that FASN may be a direct target of miR-195 by the luciferase activity assay sarcoma hsa-miR-195-5p FBXL20 -1.07154705036962 4.16544134775761e-08 0.190290133062633 0.106207235760524 MirTarget -0.120493490418222 0.000772559980162378 NA NA NA hsa-miR-195-5p FBXO22 -1.07154705036962 4.16544134775761e-08 0.391757693583077 1.51701161192718e-05 MirTarget -0.182221399102913 1.47970295876675e-11 NA NA NA hsa-miR-195-5p FBXO41 -1.07154705036962 4.16544134775761e-08 1.25775806662766 7.25107828917888e-10 mirMAP -0.222513558291367 0.000548079415075542 NA NA NA hsa-miR-195-5p FNDC3B -1.07154705036962 4.16544134775761e-08 0.634855476727409 4.26987304910224e-08 MirTarget -0.15314620888999 2.02717846334812e-05 NA NA NA hsa-miR-195-5p FOPNL -1.07154705036962 4.16544134775761e-08 0.167137471255288 0.0641736231585254 MirTarget -0.177140328073668 2.54225022344286e-11 NA NA NA hsa-miR-195-5p FRYL -1.07154705036962 4.16544134775761e-08 0.078328870763662 0.464844754165977 miRNATAP -0.118138800091382 0.00027120687872032 NA NA NA hsa-miR-195-5p G2E3 -1.07154705036962 4.16544134775761e-08 0.523561054935608 1.28760869270232e-06 miRNATAP -0.280795101826909 4.5385252181881e-19 NA NA NA hsa-miR-195-5p GALNT1 -1.07154705036962 4.16544134775761e-08 0.0125653271813269 0.91022847750809 MirTarget -0.145329367200007 1.49058830532686e-05 NA NA NA hsa-miR-195-5p GALNT7 -1.07154705036962 4.16544134775761e-08 -0.0158472183255354 0.923732906080542 MirTarget -0.144294686187528 0.00428340481194087 NA NA NA hsa-miR-195-5p GATAD2A -1.07154705036962 4.16544134775761e-08 0.520662018069515 1.22690304503428e-08 MirTarget;miRNATAP -0.15287391736203 4.8716675986019e-08 NA NA NA hsa-miR-195-5p GNAI3 -1.07154705036962 4.16544134775761e-08 0.0993649476462464 0.198343316607369 MirTarget -0.132508063191942 6.49924708705991e-09 NA NA NA hsa-miR-195-5p GNB1L -1.07154705036962 4.16544134775761e-08 0.391587870496203 0.00216407515158901 mirMAP -0.11166631455828 0.00443777361009346 NA NA NA hsa-miR-195-5p GOLGA4 -1.07154705036962 4.16544134775761e-08 0.0668555129502852 0.601837372774509 MirTarget -0.25327602756648 1.87314851192955e-11 NA NA NA hsa-miR-195-5p GOLT1B -1.07154705036962 4.16544134775761e-08 0.427458875480666 0.000319974089957985 MirTarget -0.237281882934935 1.95012640291768e-11 NA NA NA hsa-miR-195-5p GPATCH8 -1.07154705036962 4.16544134775761e-08 0.265669777736136 0.000342893803669977 MirTarget -0.131627031491128 2.62647524259086e-09 NA NA NA hsa-miR-195-5p GRIN1 -1.07154705036962 4.16544134775761e-08 0.355463228978419 0.254031518762628 mirMAP -0.209318846219632 0.0287271843786117 NA NA NA hsa-miR-195-5p GRSF1 -1.07154705036962 4.16544134775761e-08 0.129957582549358 0.119390526378944 mirMAP -0.136821641122364 3.45586447064095e-08 NA NA NA hsa-miR-195-5p GSTCD -1.07154705036962 4.16544134775761e-08 0.393970477834123 0.00112217829372281 MirTarget -0.286495377018612 4.28599079595777e-16 NA NA NA hsa-miR-195-5p GTF3C5 -1.07154705036962 4.16544134775761e-08 0.217578738092318 0.0510614913541808 MirTarget -0.132399596272954 9.03756291870065e-05 NA NA NA hsa-miR-195-5p HECTD1 -1.07154705036962 4.16544134775761e-08 -0.106152421737443 0.264016507204639 miRNATAP -0.141643231510664 6.29067684752457e-07 NA NA NA hsa-miR-195-5p HELZ -1.07154705036962 4.16544134775761e-08 0.176175036710462 0.0467006752430842 MirTarget;miRNATAP -0.104906035525554 8.90528097416227e-05 NA NA NA hsa-miR-195-5p HIRA -1.07154705036962 4.16544134775761e-08 0.26012568380798 0.00252561852468465 MirTarget;miRNATAP -0.109806388489889 2.56542272073301e-05 NA NA NA hsa-miR-195-5p HMGA1 -1.07154705036962 4.16544134775761e-08 1.18826152290305 1.85036671713383e-08 miRNATAP -0.23227530563916 0.00045096126062739 27175617 Downregulation of miR 195 promotes prostate cancer progression by targeting HMGA1; miR-195 overexpression inhibited cell proliferation cell cycle progression and tumorigenesis via directly targeting HMGA1; Downregulation of HMGA1 expression had an effect similar to miR-195 in the PCa cells; In summary our study suggests that miR-195 functions as a tumor-suppressor gene by downregulating HMGA1 and can be used as a potential target in the treatment of PCa progression;tumorigenesis prostate cancer hsa-miR-195-5p HMGA2 -1.07154705036962 4.16544134775761e-08 2.83935636900172 6.63146845909461e-11 MirTarget -0.588733944275239 1.74470139467688e-05 NA NA NA hsa-miR-195-5p HMGB3 -1.07154705036962 4.16544134775761e-08 1.54119595394867 6.85372178417965e-15 mirMAP -0.443882164921081 4.70208197674194e-13 NA NA NA hsa-miR-195-5p HN1L -1.07154705036962 4.16544134775761e-08 0.655519305162324 1.77074775351539e-10 MirTarget -0.232326566841729 7.00684902098325e-14 NA NA NA hsa-miR-195-5p HNF1A -1.07154705036962 4.16544134775761e-08 1.59951390026527 3.19279743843429e-10 mirMAP -0.162825393158662 0.0443361383005997 NA NA NA hsa-miR-195-5p HNRNPA1 -1.07154705036962 4.16544134775761e-08 0.257507680491872 0.0064471611518627 miRNATAP -0.119960925909463 2.80435953895505e-05 NA NA NA hsa-miR-195-5p HNRNPA2B1 -1.07154705036962 4.16544134775761e-08 0.5497521738082 4.56423914454513e-11 miRNATAP -0.238465785948948 9.42519540021861e-23 NA NA NA hsa-miR-195-5p HOXC11 -1.07154705036962 4.16544134775761e-08 5.83828598471246 1.82376495110612e-23 miRNATAP -0.551933959330128 0.00487097580562392 NA NA NA hsa-miR-195-5p HOXC8 -1.07154705036962 4.16544134775761e-08 4.79305859474861 8.50282039219722e-27 miRNATAP -0.830893688075854 2.25986894909398e-08 NA NA NA hsa-miR-195-5p HSPA4L -1.07154705036962 4.16544134775761e-08 -0.099897034975418 0.743997596825237 MirTarget -0.246479934687371 0.00848273384322653 NA NA NA hsa-miR-195-5p IARS -1.07154705036962 4.16544134775761e-08 0.525353820497922 2.86793833786198e-06 MirTarget -0.246368931183043 1.60489177923312e-13 NA NA NA hsa-miR-195-5p IDH3A -1.07154705036962 4.16544134775761e-08 -0.0528080063439349 0.628597238614577 MirTarget -0.124386988404276 0.00016520182477477 NA NA NA hsa-miR-195-5p IGF1R -1.07154705036962 4.16544134775761e-08 0.116961071763603 0.57112438908184 miRNATAP -0.137649221915613 0.02965949583708 NA NA NA hsa-miR-195-5p IGF2BP1 -1.07154705036962 4.16544134775761e-08 3.05827422435903 7.03606215119629e-06 mirMAP -0.507285195768145 0.0170930101025302 NA NA NA hsa-miR-195-5p IGF2R -1.07154705036962 4.16544134775761e-08 0.403916991451365 0.00121884979722363 MirTarget -0.14426841313303 0.000158356923511281 NA NA NA hsa-miR-195-5p IPO7 -1.07154705036962 4.16544134775761e-08 0.357155727271068 0.00106813004083192 MirTarget;miRNATAP -0.205764932301018 2.59283683898049e-10 NA NA NA hsa-miR-195-5p IPO9 -1.07154705036962 4.16544134775761e-08 0.626203690349035 2.54745694168132e-13 miRNATAP -0.151241201218186 1.41787514192029e-08 NA NA NA hsa-miR-195-5p IRF2BP2 -1.07154705036962 4.16544134775761e-08 0.35136442987087 6.96654000668309e-05 miRNATAP -0.136920675878291 3.01262484082164e-07 NA NA NA hsa-miR-195-5p ISM2 -1.07154705036962 4.16544134775761e-08 0.870746574974917 0.07299207136836 mirMAP -0.303832089481739 0.0422176772509434 NA NA NA hsa-miR-195-5p ITGA2 -1.07154705036962 4.16544134775761e-08 1.17725809498257 2.34860811208909e-08 MirTarget;miRNATAP -0.407639234478228 2.37972891134613e-10 NA NA NA hsa-miR-195-5p IVNS1ABP -1.07154705036962 4.16544134775761e-08 0.690170993037015 3.92331176139898e-08 MirTarget -0.282175356658998 6.52976053637734e-14 NA NA NA hsa-miR-195-5p KBTBD2 -1.07154705036962 4.16544134775761e-08 0.453972595462794 5.35863049191991e-10 miRNATAP -0.116880971095984 2.04821595913117e-07 NA NA NA hsa-miR-195-5p KCNJ2 -1.07154705036962 4.16544134775761e-08 0.715735490663241 0.0012607689075355 MirTarget;miRNATAP -0.302292258938357 8.0509114836714e-06 NA NA NA hsa-miR-195-5p KDM2A -1.07154705036962 4.16544134775761e-08 0.282795525996143 0.00693994548789185 mirMAP -0.1017824995313 0.00147031894867906 NA NA NA hsa-miR-195-5p KDSR -1.07154705036962 4.16544134775761e-08 0.239472778487095 0.0221636390920047 miRNATAP -0.167697196770104 9.00082907643043e-08 NA NA NA hsa-miR-195-5p KIF16B -1.07154705036962 4.16544134775761e-08 -0.0269042938568225 0.815282298888949 miRNATAP -0.101289707598272 0.00384369482197958 NA NA NA hsa-miR-195-5p KIF21A -1.07154705036962 4.16544134775761e-08 0.0644715211443456 0.660461017004779 MirTarget -0.301939981831555 2.40425200736602e-12 NA NA NA hsa-miR-195-5p KIF26B -1.07154705036962 4.16544134775761e-08 2.57786168634948 1.73410142887553e-23 mirMAP -0.365423675014282 1.97488344670865e-05 NA NA NA hsa-miR-195-5p KIF5B -1.07154705036962 4.16544134775761e-08 0.362139773365226 0.000658119616719543 miRNATAP -0.16837014139519 1.54492501856119e-07 NA NA NA hsa-miR-195-5p KLHL18 -1.07154705036962 4.16544134775761e-08 0.124203607147546 0.154866222179286 MirTarget -0.109275531777839 3.22025660380718e-05 NA NA NA hsa-miR-195-5p KPNA1 -1.07154705036962 4.16544134775761e-08 0.162129980216026 0.0194318139799775 MirTarget;miRNATAP -0.106802364020615 2.32547720215016e-07 NA NA NA hsa-miR-195-5p KPNA3 -1.07154705036962 4.16544134775761e-08 0.252104157916224 0.00901567663252874 miRNATAP -0.207551774046711 2.09385425365874e-13 NA NA NA hsa-miR-195-5p KPNA4 -1.07154705036962 4.16544134775761e-08 0.138060971190837 0.137094124998354 miRNATAP -0.161014614986216 5.1090362822284e-09 NA NA NA hsa-miR-195-5p KPNA6 -1.07154705036962 4.16544134775761e-08 0.116490780512301 0.10622437759634 mirMAP;miRNATAP -0.100431344645136 3.10649835083345e-06 NA NA NA hsa-miR-107 LAMC1 0.85152957824299 1.22369651446858e-11 0.370285667657678 0.0366283240859651 miRanda -0.301124576057999 0.000348957719891837 NA NA NA hsa-miR-126-5p LAMC1 0.450893496822779 0.0112966412858755 0.370285667657678 0.0366283240859651 mirMAP -0.204423638001076 0.000795330168099449 NA NA NA hsa-miR-140-5p LAMC1 0.132398579631585 0.457960134430787 0.370285667657678 0.0366283240859651 MirTarget;PITA;miRanda;miRNATAP -0.261592794262214 1.64672141876271e-05 NA NA NA hsa-miR-146b-5p LAMC1 2.23105707690238 3.83997814011313e-23 0.370285667657678 0.0366283240859651 miRanda -0.18146276886274 3.4354268406317e-05 NA NA NA hsa-miR-15a-5p LAMC1 1.07800995489566 4.32072598796529e-10 0.370285667657678 0.0366283240859651 MirTarget -0.36380416437207 9.57010535911872e-10 NA NA NA hsa-miR-15b-5p LAMC1 0.637819606405168 0.000580041575431604 0.370285667657678 0.0366283240859651 MirTarget -0.289362154844077 4.5730258025572e-07 NA NA NA hsa-miR-16-5p LAMC1 0.468459442059375 0.02635007201346 0.370285667657678 0.0366283240859651 miRNAWalker2_validate;MirTarget -0.34568030515619 2.92954987151097e-12 NA NA NA hsa-miR-182-5p LAMC1 1.73826081735237 5.69817940588551e-09 0.370285667657678 0.0366283240859651 miRNATAP -0.24769080487935 2.10491951902756e-13 NA NA NA hsa-miR-186-5p LAMC1 0.35512789129261 0.0196931838168008 0.370285667657678 0.0366283240859651 mirMAP -0.337679821870404 1.91677646135264e-06 NA NA NA hsa-miR-188-5p LAMC1 1.57437249320621 2.78824007819973e-08 0.370285667657678 0.0366283240859651 MirTarget -0.13858753675395 0.000380800640543809 NA NA NA hsa-miR-193a-3p LAMC1 0.148284355948959 0.379093889907371 0.370285667657678 0.0366283240859651 MirTarget;PITA;miRanda -0.136933286540383 0.0357552949392845 NA NA NA hsa-miR-193b-3p LAMC1 -0.0325435210716751 0.883410452152887 0.370285667657678 0.0366283240859651 MirTarget -0.103365009076654 0.0357911842856895 NA NA NA hsa-miR-200b-3p LAMC1 2.06025765178663 3.07718049337497e-10 0.370285667657678 0.0366283240859651 MirTarget;TargetScan -0.246259940243578 3.71481628992343e-16 NA NA NA hsa-miR-200c-3p LAMC1 1.74925752003763 3.42000026705311e-08 0.370285667657678 0.0366283240859651 MirTarget;miRNATAP -0.249688858971602 2.7176899946246e-15 NA NA NA hsa-miR-29a-3p LAMC1 -0.235052170104117 0.138527567930958 0.370285667657678 0.0366283240859651 MirTarget;miRNATAP -0.540972878789512 1.21184059816068e-16 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29b-3p LAMC1 0.0225365195743876 0.914313337784307 0.370285667657678 0.0366283240859651 MirTarget;miRNATAP -0.460253233577372 1.33176960026411e-21 NA NA NA hsa-miR-29c-3p LAMC1 -1.34143813218298 2.77493790306384e-12 0.370285667657678 0.0366283240859651 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.255427761607858 1.89773257657361e-06 NA NA NA hsa-miR-320b LAMC1 1.21733873788625 7.99882585998487e-07 0.370285667657678 0.0366283240859651 miRanda -0.139586224790244 0.00116125404115432 NA NA NA hsa-miR-338-3p LAMC1 -0.0138760121093551 0.956163634155272 0.370285667657678 0.0366283240859651 MirTarget;miRanda -0.18677672559407 1.15906946136847e-05 NA NA NA hsa-miR-33a-3p LAMC1 0.21453033253985 0.371591474252951 0.370285667657678 0.0366283240859651 mirMAP -0.246784623754038 1.07319006353007e-07 NA NA NA hsa-miR-362-3p LAMC1 0.994614346444282 4.39793878186399e-05 0.370285667657678 0.0366283240859651 miRanda -0.262897903033329 3.0087687360792e-09 NA NA NA hsa-miR-374a-5p LAMC1 0.239597788731458 0.0202963000797544 0.370285667657678 0.0366283240859651 mirMAP -0.253019751086461 0.020186846195087 NA NA NA hsa-miR-374b-5p LAMC1 0.00249900187478502 0.985380083859555 0.370285667657678 0.0366283240859651 mirMAP -0.178251790110345 0.0284586917735997 NA NA NA hsa-miR-424-5p LAMC1 0.956135912596328 0.00035164943928494 0.370285667657678 0.0366283240859651 MirTarget;miRNATAP -0.147493817928623 0.000217586840492112 NA NA NA hsa-miR-429 LAMC1 1.58250682050303 4.75828087352234e-05 0.370285667657678 0.0366283240859651 MirTarget;PITA;miRanda;miRNATAP -0.209839361894973 1.99209293409558e-15 NA NA NA hsa-miR-577 LAMC1 0.615893340074725 0.210494450869356 0.370285667657678 0.0366283240859651 PITA -0.11681997382697 7.52013668940607e-07 NA NA NA hsa-miR-590-3p LAMC1 0.858742926831233 0.000127281269371976 0.370285667657678 0.0366283240859651 PITA;miRanda;mirMAP -0.353952907766387 1.01875179161225e-14 NA NA NA hsa-miR-7-1-3p LAMC1 0.94398354303717 7.5771319809992e-05 0.370285667657678 0.0366283240859651 mirMAP -0.28536547268048 5.2424722666758e-11 NA NA NA hsa-miR-92a-3p LAMC1 1.06124545165614 6.51550014372282e-08 0.370285667657678 0.0366283240859651 miRNAWalker2_validate -0.220119230160509 4.06172849280034e-05 NA NA NA hsa-miR-942-5p LAMC1 0.971074085161366 9.47503417656145e-05 0.370285667657678 0.0366283240859651 MirTarget -0.322548188660511 3.40563100526069e-15 NA NA NA hsa-miR-96-5p LAMC1 1.44821155854693 6.56312590328933e-06 0.370285667657678 0.0366283240859651 MirTarget;TargetScan;miRNATAP -0.223185392616619 6.61668212778562e-11 NA NA NA hsa-miR-98-5p LAMC1 0.72508924193932 6.07191196761022e-10 0.370285667657678 0.0366283240859651 miRNAWalker2_validate -0.188480153680342 0.0407044980467923 NA NA NA hsa-miR-195-5p LATS1 -1.07154705036962 4.16544134775761e-08 0.108677825624674 0.342084497365957 MirTarget;miRNATAP -0.182425588401917 9.40699731457855e-08 NA NA NA hsa-miR-195-5p LCORL -1.07154705036962 4.16544134775761e-08 0.269077512733446 0.0208092037854433 MirTarget;miRNATAP -0.261080063665773 1.48819847095906e-14 NA NA NA hsa-miR-195-5p LETM1 -1.07154705036962 4.16544134775761e-08 0.169358924200482 0.178897540946374 mirMAP -0.196801466208938 1.86783115772949e-07 NA NA NA hsa-miR-195-5p LMNB2 -1.07154705036962 4.16544134775761e-08 1.26630430723531 1.2672982891423e-17 mirMAP -0.294240374157887 3.72515403434454e-10 NA NA NA hsa-miR-195-5p LRIG2 -1.07154705036962 4.16544134775761e-08 0.233646121703766 0.020894431221445 MirTarget -0.111559297665586 0.000284578787789613 NA NA NA hsa-miR-195-5p LRP6 -1.07154705036962 4.16544134775761e-08 0.526407698113248 1.3788363910036e-05 miRNATAP -0.179968417540239 1.14169827386675e-06 NA NA NA hsa-miR-195-5p LRRC14 -1.07154705036962 4.16544134775761e-08 0.306310883527709 0.000401505117212254 mirMAP -0.100762272177631 0.000133852192954048 NA NA NA hsa-miR-195-5p LRRC20 -1.07154705036962 4.16544134775761e-08 0.325630193113761 0.0249241871776354 mirMAP -0.121191404758318 0.00648319610859415 NA NA NA hsa-miR-195-5p LRRC58 -1.07154705036962 4.16544134775761e-08 0.66871614549604 1.31610828919559e-10 miRNATAP -0.316693007216918 3.24101294086915e-26 NA NA NA hsa-miR-195-5p LSM11 -1.07154705036962 4.16544134775761e-08 0.273916573216644 0.0292937409084412 miRNAWalker2_validate;MirTarget -0.191281415493267 4.25811958297105e-07 NA NA NA hsa-miR-195-5p LURAP1L -1.07154705036962 4.16544134775761e-08 0.456363320793577 0.0193737261905497 MirTarget -0.160261562789499 0.00753051013157767 NA NA NA hsa-miR-195-5p MAN2A2 -1.07154705036962 4.16544134775761e-08 0.413403202487504 7.90336682297939e-05 MirTarget -0.163656403484559 2.55061579550406e-07 NA NA NA hsa-miR-195-5p MAP3K4 -1.07154705036962 4.16544134775761e-08 0.057854154661781 0.542294953685194 miRNATAP -0.156102353367633 3.1928992885035e-08 NA NA NA hsa-miR-195-5p MAP7 -1.07154705036962 4.16544134775761e-08 0.909677597558388 3.9542355756595e-06 MirTarget;miRNATAP -0.377413088497681 2.44690169367033e-10 NA NA NA hsa-miR-195-5p MAPK1 -1.07154705036962 4.16544134775761e-08 -0.0171538275729688 0.814645329854297 mirMAP -0.103164505308584 2.20049902079219e-06 NA NA NA hsa-miR-195-5p MBNL3 -1.07154705036962 4.16544134775761e-08 0.0695129691997547 0.669219217920827 MirTarget -0.127549321254958 0.0103227876043175 NA NA NA hsa-miR-195-5p MDM4 -1.07154705036962 4.16544134775761e-08 0.345358152785799 0.00761701135215303 mirMAP -0.140864462454713 0.000365142665816775 NA NA NA hsa-miR-195-5p MED13 -1.07154705036962 4.16544134775761e-08 0.32022796034572 0.00316613047259726 MirTarget;miRNATAP -0.224347313529721 2.45400201927427e-12 NA NA NA hsa-miR-195-5p MGAT5 -1.07154705036962 4.16544134775761e-08 0.380532541237905 0.00397677233800512 mirMAP -0.100873304598983 0.0130945626273861 NA NA NA hsa-miR-195-5p MIB1 -1.07154705036962 4.16544134775761e-08 0.377930072259812 0.0014356013263503 miRNATAP -0.186287511102804 1.95325673376934e-07 NA NA NA hsa-miR-195-5p MOCOS -1.07154705036962 4.16544134775761e-08 0.916061955761737 7.41986183646553e-05 mirMAP -0.320082942719721 6.28352438715118e-06 NA NA NA hsa-miR-195-5p MOV10 -1.07154705036962 4.16544134775761e-08 0.294826585524834 0.01078805379891 miRNATAP -0.112531867765152 0.00145286949738493 NA NA NA hsa-miR-195-5p MSX1 -1.07154705036962 4.16544134775761e-08 1.16288393784974 3.06123754171918e-08 mirMAP -0.197494393899596 0.00275408750092994 NA NA NA hsa-miR-195-5p MTMR4 -1.07154705036962 4.16544134775761e-08 0.121948193731569 0.208289983049091 MirTarget;miRNATAP -0.181676522432617 2.0993811868579e-10 NA NA NA hsa-miR-195-5p MYB -1.07154705036962 4.16544134775761e-08 2.23123493373074 1.58587972966078e-12 miRNATAP -0.488705425718211 9.31281513701649e-07 24486218;26622903 MicroRNA 195 inhibits non small cell lung cancer cell proliferation migration and invasion by targeting MYB; Using miRNA target prediction algorithms and reporter assays we demonstrated that miR-195 suppressed the expression of MYB both at the mRNA and protein level and was directly bound to the 3'untranslated region of MYB mRNA; Overexpression of MYB in NSCLC cells using an ectopic expression vector restored the decreased cell proliferation migration and invasion effects induced by miR-195; Finally we observed an inverse correlation between MYB and miR-195 in NSCLC;microRNA 195 inhibits the proliferation migration and invasion of cervical cancer cells via the inhibition of CCND2 and MYB expression; Moreover miR-195 repressed the expression of CCND2 and MYB in the HeLa cells at the mRNA and protein levels ; lung squamous cell cancer;cervical and endocervical cancer hsa-miR-195-5p NAA15 -1.07154705036962 4.16544134775761e-08 0.582517905902976 7.83848775172754e-10 miRNATAP -0.205247285466533 7.48419780840713e-13 NA NA NA hsa-miR-195-5p NAA25 -1.07154705036962 4.16544134775761e-08 0.881169599356607 2.98263747935198e-15 miRNATAP -0.347906018672467 1.98111959865082e-26 NA NA NA hsa-miR-195-5p NAPG -1.07154705036962 4.16544134775761e-08 -0.0344836750791524 0.746418121504312 MirTarget -0.166294674282341 1.77140700016064e-07 NA NA NA hsa-miR-195-5p NF1 -1.07154705036962 4.16544134775761e-08 0.510050104797711 2.72408746645533e-07 MirTarget -0.177166418350857 4.14561292238056e-09 NA NA NA hsa-miR-195-5p NF2 -1.07154705036962 4.16544134775761e-08 0.241666209204978 0.00997530799981614 MirTarget -0.139132980762008 8.13350462602887e-07 NA NA NA hsa-miR-195-5p NFAT5 -1.07154705036962 4.16544134775761e-08 0.461239695424155 0.000656069696676909 MirTarget -0.206280117576242 5.01384274047306e-07 NA NA NA hsa-miR-195-5p NFRKB -1.07154705036962 4.16544134775761e-08 0.229308122910265 0.00903044622870755 MirTarget;miRNATAP -0.100709220937398 0.000156659700756765 NA NA NA hsa-miR-195-5p NOB1 -1.07154705036962 4.16544134775761e-08 0.359968617866792 0.00102154589301963 MirTarget -0.114476973556647 0.000648129817155188 NA NA NA hsa-miR-195-5p NOLC1 -1.07154705036962 4.16544134775761e-08 0.827281816095402 3.03296920517241e-12 miRNAWalker2_validate -0.296839078408795 9.27633085658343e-17 NA NA NA hsa-miR-195-5p NR2C2 -1.07154705036962 4.16544134775761e-08 0.210165761701234 0.0322359853207322 MirTarget -0.151956215766362 2.39466309892814e-07 NA NA NA hsa-miR-195-5p NTSR1 -1.07154705036962 4.16544134775761e-08 1.14458256498755 0.0221825604403553 mirMAP -0.302795628231602 0.0499426202669484 NA NA NA hsa-miR-195-5p NUCKS1 -1.07154705036962 4.16544134775761e-08 0.325102076142334 0.00397222584600734 MirTarget;miRNATAP -0.11566334124897 0.000803546925460593 NA NA NA hsa-miR-195-5p NUFIP2 -1.07154705036962 4.16544134775761e-08 0.558328084822615 9.99386044950235e-12 MirTarget;miRNATAP -0.213992446354143 1.44880728833264e-18 NA NA NA hsa-miR-195-5p NUP50 -1.07154705036962 4.16544134775761e-08 0.305149149227625 0.00438128594352566 miRNATAP -0.199177469572827 4.15069111429765e-10 NA NA NA hsa-miR-195-5p NUTF2 -1.07154705036962 4.16544134775761e-08 0.353063633886568 0.00173041551609384 mirMAP -0.111530588675581 0.00123876242560973 NA NA NA hsa-miR-195-5p OGT -1.07154705036962 4.16544134775761e-08 0.511336697594968 1.43414224885473e-05 miRNATAP -0.204859304883974 9.35805937305904e-09 NA NA NA hsa-miR-195-5p OTUD3 -1.07154705036962 4.16544134775761e-08 0.435976725971797 0.00592113449804049 mirMAP -0.287915593035638 1.2268624973508e-09 NA NA NA hsa-miR-195-5p OTUD4 -1.07154705036962 4.16544134775761e-08 0.407286379443787 3.55648024777352e-05 miRNATAP -0.214037617511098 2.03269803925252e-13 NA NA NA hsa-miR-195-5p OTX1 -1.07154705036962 4.16544134775761e-08 2.98754081227376 3.59714751131807e-24 miRNATAP -0.683670297526387 6.14248417741848e-13 NA NA NA hsa-miR-195-5p PAFAH1B2 -1.07154705036962 4.16544134775761e-08 0.317927345835721 9.98932221533953e-05 MirTarget;miRNATAP -0.16705763228051 4.89247079393575e-12 NA NA NA hsa-miR-195-5p PARP14 -1.07154705036962 4.16544134775761e-08 1.15382196278919 1.04282107890379e-14 MirTarget -0.257054642549722 4.95806693964961e-08 NA NA NA hsa-miR-195-5p PCGF5 -1.07154705036962 4.16544134775761e-08 -0.170947900246937 0.0598091013138149 miRNATAP -0.100540467459116 0.000256699682427415 NA NA NA hsa-miR-195-5p PDDC1 -1.07154705036962 4.16544134775761e-08 0.259611729286865 0.00574340640325294 mirMAP -0.14562150398288 2.50975282526682e-07 NA NA NA hsa-miR-195-5p PDIK1L -1.07154705036962 4.16544134775761e-08 0.364142171701499 0.00121564664360239 MirTarget;miRNATAP -0.27500813113787 3.45815410888026e-17 NA NA NA hsa-miR-195-5p PDP1 -1.07154705036962 4.16544134775761e-08 0.684869730672071 8.90380586619804e-07 MirTarget -0.217219706433428 3.73386743410453e-07 NA NA NA hsa-miR-195-5p PDXK -1.07154705036962 4.16544134775761e-08 0.419385738226448 0.000445160686270667 MirTarget -0.167955372293745 3.77482118560354e-06 NA NA NA hsa-miR-195-5p PEX13 -1.07154705036962 4.16544134775761e-08 0.0723524031895586 0.355262990257998 MirTarget -0.190060058649544 1.60790703777163e-17 NA NA NA hsa-miR-195-5p PEX5 -1.07154705036962 4.16544134775761e-08 0.309291626285083 0.00218047754884225 MirTarget;miRNATAP -0.137139649850666 7.36161593794784e-06 NA NA NA hsa-miR-195-5p PFKFB4 -1.07154705036962 4.16544134775761e-08 0.0596472451974295 0.796171633622881 MirTarget -0.267891245752445 0.000133550999711962 NA NA NA hsa-miR-195-5p PGM2L1 -1.07154705036962 4.16544134775761e-08 1.5457179732948 1.47265017377851e-20 miRNATAP -0.247162143065696 5.35156077651078e-06 NA NA NA hsa-miR-195-5p PIAS2 -1.07154705036962 4.16544134775761e-08 0.0999742411474212 0.410460583701402 MirTarget -0.140407718188836 0.000134905312625669 NA NA NA hsa-miR-195-5p PIKFYVE -1.07154705036962 4.16544134775761e-08 0.176813650074187 0.0954863222067187 MirTarget -0.126846920611992 7.76502527969903e-05 NA NA NA hsa-miR-195-5p PLEKHA1 -1.07154705036962 4.16544134775761e-08 0.13326283541206 0.23636502532347 MirTarget;miRNATAP -0.165821596312243 9.10432751513156e-07 NA NA NA hsa-miR-195-5p PLEKHA5 -1.07154705036962 4.16544134775761e-08 -0.0209985094569882 0.878336125773638 MirTarget -0.153468213577495 0.000224624230626556 NA NA NA hsa-miR-195-5p PLEKHB2 -1.07154705036962 4.16544134775761e-08 0.116079604134187 0.255624605432485 MirTarget -0.16452807510623 6.58475018465255e-08 NA NA NA hsa-miR-195-5p PMEPA1 -1.07154705036962 4.16544134775761e-08 1.87104318783471 2.71674336465521e-13 mirMAP -0.242358207638343 0.00319286757768196 NA NA NA hsa-miR-195-5p POLD3 -1.07154705036962 4.16544134775761e-08 0.779249631190707 1.33964682266536e-08 MirTarget -0.265385451587532 2.21055395582537e-10 NA NA NA hsa-miR-195-5p POLR3F -1.07154705036962 4.16544134775761e-08 0.348411560497216 0.00117276485441734 MirTarget;miRNATAP -0.116595100413807 0.000383384800022263 NA NA NA hsa-miR-195-5p POU2F1 -1.07154705036962 4.16544134775761e-08 0.891514407227645 8.27712775920405e-15 miRNATAP -0.282162279346396 8.70071203061524e-16 NA NA NA hsa-miR-195-5p PPM1D -1.07154705036962 4.16544134775761e-08 0.0652001574287979 0.393557277823306 MirTarget;miRNATAP -0.127284380068394 1.78813212886162e-08 NA NA NA hsa-miR-195-5p PPP2R1B -1.07154705036962 4.16544134775761e-08 0.141286513472044 0.201665698854979 MirTarget -0.13157210220167 8.49104716697063e-05 NA NA NA hsa-miR-195-5p PPP6R3 -1.07154705036962 4.16544134775761e-08 0.133888427732233 0.095735401723862 MirTarget;miRNATAP -0.137143239179275 8.47341957362445e-09 NA NA NA hsa-miR-195-5p PPRC1 -1.07154705036962 4.16544134775761e-08 0.736475066031236 3.4566812735482e-14 miRNATAP -0.173875529342908 1.10533340798672e-08 NA NA NA hsa-miR-195-5p PRDM4 -1.07154705036962 4.16544134775761e-08 0.0197830982140079 0.806026476808389 MirTarget;miRNATAP -0.108907215691099 6.19638932520805e-06 NA NA NA hsa-miR-195-5p PRKAA1 -1.07154705036962 4.16544134775761e-08 0.317356827284011 0.00310431938627586 MirTarget -0.21912622950092 4.80258274793383e-12 NA NA NA hsa-miR-195-5p PRR14L -1.07154705036962 4.16544134775761e-08 0.428621965595346 2.51475590909074e-05 mirMAP -0.241310023074171 5.60168853271252e-16 NA NA NA hsa-miR-195-5p PRRC2C -1.07154705036962 4.16544134775761e-08 0.761755229890794 8.69075150817589e-16 MirTarget -0.22210225979217 2.57610448859563e-14 NA NA NA hsa-miR-195-5p PSAT1 -1.07154705036962 4.16544134775761e-08 0.84276202089434 0.00272908884883075 MirTarget -0.408684719021465 1.75554122368914e-06 NA NA NA hsa-miR-195-5p PSMA5 -1.07154705036962 4.16544134775761e-08 0.22865697247846 0.0278130128690221 MirTarget -0.125101174675257 7.17542352350638e-05 NA NA NA hsa-miR-195-5p PTPN4 -1.07154705036962 4.16544134775761e-08 0.158162719852811 0.069068985756004 miRNATAP -0.137065379007271 1.29668825716591e-07 NA NA NA hsa-miR-195-5p PURB -1.07154705036962 4.16544134775761e-08 0.191156761618797 0.0680497522728757 miRNATAP -0.151655331826568 1.4701422451407e-06 NA NA NA hsa-miR-195-5p RAB10 -1.07154705036962 4.16544134775761e-08 -0.123006300487147 0.177665159428609 MirTarget;miRNATAP -0.133991664278332 9.31289206320776e-07 NA NA NA hsa-miR-195-5p RAD23B -1.07154705036962 4.16544134775761e-08 0.10839487627434 0.174140420183553 MirTarget;miRNATAP -0.179344854303723 6.56207795851573e-15 NA NA NA hsa-miR-195-5p RAD50 -1.07154705036962 4.16544134775761e-08 0.108139021675818 0.233439037777841 MirTarget -0.12000139227679 1.08194716344987e-05 NA NA NA hsa-miR-195-5p RALGAPB -1.07154705036962 4.16544134775761e-08 0.354066204360086 0.000421066824033866 miRNATAP -0.156056957395118 2.68529165974492e-07 NA NA NA hsa-miR-195-5p RAP2C -1.07154705036962 4.16544134775761e-08 0.253225539349462 0.00420340939327842 MirTarget;miRNATAP -0.119915637092035 7.22423486913484e-06 NA NA NA hsa-miR-195-5p RBBP6 -1.07154705036962 4.16544134775761e-08 0.162900336526808 0.0510081318834689 MirTarget;miRNATAP -0.112668743145526 7.06582302068314e-06 NA NA NA hsa-miR-195-5p RBM12 -1.07154705036962 4.16544134775761e-08 0.306383171270709 3.2646579580345e-06 MirTarget -0.152044290653392 2.65366173871471e-15 NA NA NA hsa-miR-195-5p RBPJ -1.07154705036962 4.16544134775761e-08 0.233248695691198 0.00585943920555178 MirTarget -0.162623715991595 7.95571324052724e-11 NA NA NA hsa-miR-195-5p RCOR1 -1.07154705036962 4.16544134775761e-08 -0.0080319208885955 0.943729577347503 mirMAP -0.170750736841356 5.41068970804636e-07 NA NA NA hsa-miR-195-5p RDH13 -1.07154705036962 4.16544134775761e-08 0.279141538379717 0.0180126649483886 MirTarget -0.134776129131251 0.000174661829315511 NA NA NA hsa-miR-195-5p RFK -1.07154705036962 4.16544134775761e-08 0.0212238751256484 0.872725679336171 MirTarget -0.118608410915678 0.00328884318430836 NA NA NA hsa-miR-195-5p RHPN2 -1.07154705036962 4.16544134775761e-08 1.36961038003026 6.67896616968168e-07 MirTarget -0.216320906598121 0.0122468109920245 NA NA NA hsa-miR-195-5p RICTOR -1.07154705036962 4.16544134775761e-08 0.387516049901938 0.00188233465370784 MirTarget;miRNATAP -0.193780992320986 2.67520218800951e-07 NA NA NA hsa-miR-195-5p RNF138 -1.07154705036962 4.16544134775761e-08 0.22213432812513 0.0222758481169722 MirTarget;miRNATAP -0.184880967605439 1.26664552280899e-10 NA NA NA hsa-miR-195-5p RNF43 -1.07154705036962 4.16544134775761e-08 1.45477032527532 5.14328546634921e-06 MirTarget;miRNATAP -0.27448668858096 0.00582406215886145 NA NA NA hsa-miR-195-5p RPRD1B -1.07154705036962 4.16544134775761e-08 0.555959859671098 4.14155707973188e-09 MirTarget -0.208442102702269 2.2439282771278e-13 NA NA NA hsa-miR-195-5p RPS6KA3 -1.07154705036962 4.16544134775761e-08 0.25562324842552 0.02419259011319 MirTarget;miRNATAP -0.166697572650804 1.0638506425174e-06 NA NA NA hsa-miR-195-5p RPS6KL1 -1.07154705036962 4.16544134775761e-08 1.02262377316858 3.04912541729416e-07 mirMAP -0.245115747059258 7.86596110636958e-05 NA NA NA hsa-miR-195-5p RREB1 -1.07154705036962 4.16544134775761e-08 0.212852608662661 0.0287209041741738 mirMAP;miRNATAP -0.1413531407081 1.36066242253661e-06 NA NA NA hsa-miR-195-5p RSBN1 -1.07154705036962 4.16544134775761e-08 -0.0117811591151229 0.891572467045118 MirTarget;miRNATAP -0.103776267982416 6.55465674143596e-05 NA NA NA hsa-miR-195-5p RTN3 -1.07154705036962 4.16544134775761e-08 0.129508267412936 0.101669044786989 MirTarget -0.149248261419952 1.3950814812297e-10 NA NA NA hsa-miR-195-5p SALL4 -1.07154705036962 4.16544134775761e-08 4.32264669519468 7.75605714103246e-23 miRNATAP -0.651955379500604 7.11958142769295e-06 NA NA NA hsa-miR-195-5p SAMD10 -1.07154705036962 4.16544134775761e-08 0.629453204785468 0.00018969600365916 MirTarget -0.179696343780536 0.000543957524576668 NA NA NA hsa-miR-195-5p SATB2 -1.07154705036962 4.16544134775761e-08 1.3305053528686 1.03030765028331e-07 miRNATAP -0.440676697957437 8.98279385470363e-09 NA NA NA hsa-miR-195-5p SBNO1 -1.07154705036962 4.16544134775761e-08 0.483102985063907 2.43284222028208e-06 MirTarget -0.25035555375625 7.9554347521567e-17 NA NA NA hsa-miR-195-5p SCAF11 -1.07154705036962 4.16544134775761e-08 0.282666026291658 0.00110775971545791 MirTarget -0.150246735742287 6.61799909402642e-09 NA NA NA hsa-miR-195-5p SEH1L -1.07154705036962 4.16544134775761e-08 0.679642532726401 4.83276447134959e-09 MirTarget;miRNATAP -0.235562657235152 2.42826975238529e-11 NA NA NA hsa-miR-195-5p SEPT11 -1.07154705036962 4.16544134775761e-08 0.861814443885125 2.18330634522929e-15 MirTarget -0.122818092465529 0.000435002119673203 NA NA NA hsa-miR-195-5p SERBP1 -1.07154705036962 4.16544134775761e-08 0.233665299950079 0.00254207202429813 MirTarget;miRNATAP -0.177799886185526 2.29334193088929e-15 NA NA NA hsa-miR-195-5p SGPL1 -1.07154705036962 4.16544134775761e-08 0.665608695036418 4.5008798147104e-08 MirTarget -0.274148225285044 5.22559218825205e-14 NA NA NA hsa-miR-195-5p SIX4 -1.07154705036962 4.16544134775761e-08 1.38005713985876 2.88748236517297e-07 miRNATAP -0.311429984530204 0.000202950910126603 NA NA NA hsa-miR-195-5p SLC12A2 -1.07154705036962 4.16544134775761e-08 0.430388182114123 0.0596936645281683 MirTarget;miRNATAP -0.211508170729112 0.00251600464776491 NA NA NA hsa-miR-195-5p SLC25A15 -1.07154705036962 4.16544134775761e-08 0.429834105442948 0.00448738480843146 MirTarget -0.209374690871359 5.17000450879616e-06 NA NA NA hsa-miR-195-5p SLC25A43 -1.07154705036962 4.16544134775761e-08 0.196948673335441 0.0973067874916641 MirTarget -0.141172847650358 8.82498891310167e-05 NA NA NA hsa-miR-195-5p SLC35E3 -1.07154705036962 4.16544134775761e-08 0.210132322384849 0.0782307866756419 mirMAP -0.140409676929258 0.000104746296653187 NA NA NA hsa-miR-195-5p SLC35F5 -1.07154705036962 4.16544134775761e-08 -0.0828274873873207 0.441000697835077 MirTarget -0.116830536946584 0.000332751716881417 NA NA NA hsa-miR-195-5p SLC39A9 -1.07154705036962 4.16544134775761e-08 0.128283811513021 0.136784320873422 MirTarget -0.16572322971642 6.20250385888253e-11 NA NA NA hsa-miR-195-5p SLC44A1 -1.07154705036962 4.16544134775761e-08 0.434756218586184 0.000117325296006433 mirMAP -0.220408836265964 6.28147102907389e-11 NA NA NA hsa-miR-195-5p SLC45A4 -1.07154705036962 4.16544134775761e-08 0.520395896189726 0.00029992144561396 mirMAP -0.150052634403952 0.000704990950136884 NA NA NA hsa-miR-195-5p SLC4A7 -1.07154705036962 4.16544134775761e-08 -0.178817173213505 0.203725638667682 MirTarget;miRNATAP -0.101786007193616 0.0180862727299271 NA NA NA hsa-miR-195-5p SLC5A3 -1.07154705036962 4.16544134775761e-08 0.493095639876834 5.1176177250296e-05 miRNATAP -0.311512597812248 1.08261430470778e-18 NA NA NA hsa-miR-195-5p SLC9A6 -1.07154705036962 4.16544134775761e-08 -0.167410411419524 0.0488175203891312 MirTarget;miRNATAP -0.121312628556067 1.9328614474454e-06 NA NA NA hsa-miR-195-5p SMAD5 -1.07154705036962 4.16544134775761e-08 0.185272436777386 0.0565853388312257 MirTarget;miRNATAP -0.141496336359189 1.24433772439078e-06 NA NA NA hsa-miR-195-5p SNRNP48 -1.07154705036962 4.16544134775761e-08 0.454629856219168 5.72582300427606e-05 MirTarget -0.19308709393855 1.54109040986383e-08 NA NA NA hsa-miR-195-5p SNRPB2 -1.07154705036962 4.16544134775761e-08 0.497043471196621 0.00014568524460703 MirTarget -0.107507563435404 0.00788191388552333 NA NA NA hsa-miR-195-5p SOCS6 -1.07154705036962 4.16544134775761e-08 -0.189232538885554 0.131214785830355 miRNATAP -0.186049644687857 7.94344285518236e-07 NA NA NA hsa-miR-195-5p SON -1.07154705036962 4.16544134775761e-08 0.168487112479211 0.0440632380826114 miRNATAP -0.141399390487278 1.29795219782261e-08 NA NA NA hsa-miR-195-5p SOWAHC -1.07154705036962 4.16544134775761e-08 -0.16935987546375 0.304931832982079 MirTarget;miRNATAP -0.112526644397424 0.0260962718901497 NA NA NA hsa-miR-195-5p SPEN -1.07154705036962 4.16544134775761e-08 0.341457277877713 6.72537727022002e-05 MirTarget;miRNATAP -0.104473536223866 6.50188243464982e-05 NA NA NA hsa-miR-195-5p SPRED1 -1.07154705036962 4.16544134775761e-08 0.430933109200283 1.42888890158604e-05 miRNATAP -0.104907522974596 0.000608338738549957 NA NA NA hsa-miR-195-5p SPRY4 -1.07154705036962 4.16544134775761e-08 0.815423288705948 7.84372446003749e-08 miRNATAP -0.127154531691289 0.00759372838809462 NA NA NA hsa-miR-195-5p SPTBN1 -1.07154705036962 4.16544134775761e-08 0.561275562374965 5.96130333653201e-06 miRNAWalker2_validate;mirMAP -0.204068566972056 6.37000910355698e-08 NA NA NA hsa-miR-195-5p SPTBN2 -1.07154705036962 4.16544134775761e-08 1.21770052907516 0.000199829028944301 MirTarget;miRNATAP -0.449172670193904 7.49909981598848e-06 NA NA NA hsa-miR-195-5p SPTLC1 -1.07154705036962 4.16544134775761e-08 0.135091184257692 0.107110245611355 MirTarget -0.1623092667579 4.35626843454259e-11 NA NA NA hsa-miR-195-5p SRCIN1 -1.07154705036962 4.16544134775761e-08 0.981873985808293 0.00164382899701367 mirMAP -0.244510963806488 0.0112083983207184 NA NA NA hsa-miR-195-5p SREK1 -1.07154705036962 4.16544134775761e-08 0.290692864342255 0.00261508788431193 MirTarget -0.140930083629208 1.3421060465419e-06 NA NA NA hsa-miR-195-5p SRPK1 -1.07154705036962 4.16544134775761e-08 0.718306237304153 1.54450871202261e-10 miRNATAP -0.276823289339874 1.60981923607338e-16 NA NA NA hsa-miR-195-5p SRSF11 -1.07154705036962 4.16544134775761e-08 0.317455976892377 0.00034687561621419 MirTarget;miRNATAP -0.109547091723116 5.0328131254426e-05 NA NA NA hsa-miR-195-5p SSRP1 -1.07154705036962 4.16544134775761e-08 0.457256447372486 8.10074834539344e-07 MirTarget -0.119030826025758 3.02327294332643e-05 NA NA NA hsa-miR-195-5p STEAP3 -1.07154705036962 4.16544134775761e-08 0.240945232176652 0.19723838937115 MirTarget -0.157188150147858 0.00597338229985802 NA NA NA hsa-miR-195-5p STK35 -1.07154705036962 4.16544134775761e-08 0.420087947465768 7.96791666417719e-05 mirMAP -0.139865392568615 1.71660009032893e-05 NA NA NA hsa-miR-195-5p STX3 -1.07154705036962 4.16544134775761e-08 0.327234496155115 0.0284992947104615 mirMAP -0.145892097983751 0.00140491695822103 NA NA NA hsa-miR-195-5p STXBP3 -1.07154705036962 4.16544134775761e-08 0.0663057102370503 0.438922287239625 MirTarget;miRNATAP -0.160881444498272 1.68012234855547e-10 NA NA NA hsa-miR-195-5p STYX -1.07154705036962 4.16544134775761e-08 -0.0447871564829079 0.614114876390358 miRNATAP -0.104548328468609 9.32420675004326e-05 NA NA NA hsa-miR-195-5p SUPT16H -1.07154705036962 4.16544134775761e-08 0.578847833367602 2.51518868676528e-10 MirTarget;miRNATAP -0.193520475417496 3.1361181661139e-12 NA NA NA hsa-miR-195-5p SUZ12 -1.07154705036962 4.16544134775761e-08 0.618550020331955 6.97731940287884e-10 MirTarget;miRNATAP -0.272362211104822 1.9627888769174e-20 NA NA NA hsa-miR-195-5p TAB3 -1.07154705036962 4.16544134775761e-08 -0.137642609319934 0.200368384324507 miRNAWalker2_validate;MirTarget -0.127526153235332 8.76377639382731e-05 23487264 Genome wide screening reveals that miR 195 targets the TNF α/NF κB pathway by down regulating IκB kinase alpha and TAB3 in hepatocellular carcinoma; Additionally miR-195 may exert its tumor suppressive function by decreasing the expression of multiple NF-κB downstream effectors by way of the direct targeting of IKKα and TAB3 liver cancer hsa-miR-195-5p TAF5 -1.07154705036962 4.16544134775761e-08 0.328241717816309 0.000637796254207112 miRNATAP -0.102301124032033 0.000501211336270849 NA NA NA hsa-miR-195-5p TAOK1 -1.07154705036962 4.16544134775761e-08 0.34222374126551 0.000498972568442839 MirTarget -0.169155102074262 9.88438599760486e-09 NA NA NA hsa-miR-195-5p TBCCD1 -1.07154705036962 4.16544134775761e-08 0.314584516059425 0.000121155725844881 miRNAWalker2_validate;miRTarBase -0.151718018065482 5.18265323784501e-10 NA NA NA hsa-miR-195-5p TBL1XR1 -1.07154705036962 4.16544134775761e-08 0.577694759301158 5.25990630228289e-09 MirTarget -0.269101657062569 1.1080440202387e-20 NA NA NA hsa-miR-195-5p TBPL1 -1.07154705036962 4.16544134775761e-08 0.108959912229674 0.23170480578732 miRNATAP -0.113358763984866 3.60680769526944e-05 NA NA NA hsa-miR-195-5p TFAP4 -1.07154705036962 4.16544134775761e-08 1.00649897807113 2.2028892812163e-18 miRNATAP -0.203787841820047 3.10820464355899e-08 NA NA NA hsa-miR-195-5p TFR2 -1.07154705036962 4.16544134775761e-08 0.383756850512015 0.289769607338151 mirMAP -0.253602502384412 0.0226686760685937 NA NA NA hsa-miR-195-5p THEM6 -1.07154705036962 4.16544134775761e-08 1.030531714917 1.51759238144665e-09 mirMAP -0.197846960831525 0.000222467447092206 NA NA NA hsa-miR-195-5p TMC6 -1.07154705036962 4.16544134775761e-08 1.020416407279 9.1786722865417e-11 miRNAWalker2_validate -0.158504425505592 0.00148372624073434 NA NA NA hsa-miR-195-5p TMC7 -1.07154705036962 4.16544134775761e-08 1.62331281334954 3.04480070488693e-13 MirTarget -0.215061992297297 0.00259475618265356 NA NA NA hsa-miR-195-5p TMCC1 -1.07154705036962 4.16544134775761e-08 0.246634162901872 0.00839217828410787 miRNATAP -0.129526977358645 4.49400178913284e-06 NA NA NA hsa-miR-195-5p TMEM201 -1.07154705036962 4.16544134775761e-08 1.04181350114402 4.08688485884446e-17 mirMAP -0.31071512204136 3.96485875133038e-16 NA NA NA hsa-miR-195-5p TMEM33 -1.07154705036962 4.16544134775761e-08 0.637395745036416 2.42590106451387e-08 MirTarget;miRNATAP -0.347945260371165 8.69247376261967e-27 NA NA NA hsa-miR-195-5p TMEM41A -1.07154705036962 4.16544134775761e-08 0.446413358675941 0.00110584155585631 MirTarget -0.21717989374689 1.52279757179144e-07 NA NA NA hsa-miR-195-5p TMEM87A -1.07154705036962 4.16544134775761e-08 0.216686119870697 0.0103188946226254 miRNATAP -0.122797241064063 1.31096922652779e-06 NA NA NA hsa-miR-195-5p TRAK1 -1.07154705036962 4.16544134775761e-08 0.112196213046948 0.362301040918764 miRNATAP -0.111462620189131 0.00296201351292564 NA NA NA hsa-miR-195-5p TRAM1 -1.07154705036962 4.16544134775761e-08 0.450321715583018 4.25320914797132e-05 MirTarget -0.14376798642428 1.96178367736323e-05 NA NA NA hsa-miR-195-5p TRIM2 -1.07154705036962 4.16544134775761e-08 -0.138593633483852 0.426294696378046 miRNATAP -0.230982989323788 1.14971702256528e-05 NA NA NA hsa-miR-195-5p TRIM36 -1.07154705036962 4.16544134775761e-08 0.386498538112798 0.162455862618779 miRNATAP -0.186601495043973 0.0281426379932267 NA NA NA hsa-miR-195-5p TRIM59 -1.07154705036962 4.16544134775761e-08 1.4304392115423 7.46731105604634e-21 MirTarget -0.417909699939935 1.08854259176936e-18 NA NA NA hsa-miR-195-5p TRIM67 -1.07154705036962 4.16544134775761e-08 0.880922933596874 0.000527737940631189 mirMAP -0.2626331930356 0.000799150395439423 NA NA NA hsa-miR-195-5p TTC21B -1.07154705036962 4.16544134775761e-08 0.218949158239465 0.0422280171667745 miRNATAP -0.202707381504419 2.16574939826905e-10 NA NA NA hsa-miR-195-5p TTPAL -1.07154705036962 4.16544134775761e-08 0.623711548160203 5.10779607093792e-08 MirTarget -0.187148703093956 1.01858826996818e-07 NA NA NA hsa-miR-195-5p TTYH3 -1.07154705036962 4.16544134775761e-08 1.86327522665892 1.35249438209617e-22 mirMAP -0.271666113740282 1.56225228527851e-05 NA NA NA hsa-miR-195-5p TUBA1A -1.07154705036962 4.16544134775761e-08 0.516140246584717 2.10812901173725e-06 MirTarget;miRNATAP -0.169118187613125 3.64897226134033e-07 NA NA NA hsa-miR-195-5p TXLNG -1.07154705036962 4.16544134775761e-08 0.579056283768582 3.64887637168078e-07 miRNATAP -0.263333471190327 6.67364839841477e-15 NA NA NA hsa-miR-195-5p U2SURP -1.07154705036962 4.16544134775761e-08 0.623519650021391 3.04239879239962e-10 miRNATAP -0.264471582871922 1.1775162074033e-19 NA NA NA hsa-miR-195-5p UBE2K -1.07154705036962 4.16544134775761e-08 -0.0949198500319532 0.202821455032945 MirTarget -0.151808294660588 2.63409859227709e-12 NA NA NA hsa-miR-195-5p UBE2W -1.07154705036962 4.16544134775761e-08 0.231225091423212 0.00964885326641176 miRNATAP -0.18146651346596 4.94191074054229e-12 NA NA NA hsa-miR-195-5p UBE4A -1.07154705036962 4.16544134775761e-08 0.0301493331084624 0.753607883654765 MirTarget -0.16963066890114 2.3873314606271e-09 NA NA NA hsa-miR-195-5p UBFD1 -1.07154705036962 4.16544134775761e-08 0.72360218843184 2.1155512952512e-14 MirTarget;miRNATAP -0.187177802525425 2.0847765923126e-10 NA NA NA hsa-miR-195-5p UBN2 -1.07154705036962 4.16544134775761e-08 0.424732444065439 0.000143636953961984 MirTarget;miRNATAP -0.219385052026893 4.68765399413476e-11 NA NA NA hsa-miR-195-5p UBR3 -1.07154705036962 4.16544134775761e-08 -0.0206777423176625 0.827742242328184 MirTarget;miRNATAP -0.161018218723859 1.11457107467761e-08 NA NA NA hsa-miR-195-5p UHMK1 -1.07154705036962 4.16544134775761e-08 0.650903505564446 1.41531118937306e-09 MirTarget;miRNATAP -0.285231559376404 1.91234545748196e-19 NA NA NA hsa-miR-195-5p USP14 -1.07154705036962 4.16544134775761e-08 0.533797866398384 8.71296028793021e-09 MirTarget -0.226348022398403 1.75872449038564e-16 NA NA NA hsa-miR-195-5p USP15 -1.07154705036962 4.16544134775761e-08 0.00207419255371821 0.981207188442379 MirTarget -0.133691556811599 3.51626498391718e-07 NA NA NA hsa-miR-195-5p USP31 -1.07154705036962 4.16544134775761e-08 0.970416721014479 1.34505246312873e-16 MirTarget -0.249340903810722 1.15390629544065e-11 NA NA NA hsa-miR-195-5p USP40 -1.07154705036962 4.16544134775761e-08 0.109178137608461 0.213234058910374 mirMAP -0.103801049016194 8.65782738131309e-05 NA NA NA hsa-miR-195-5p USP9X -1.07154705036962 4.16544134775761e-08 0.221792299917504 0.0168897004855897 miRNATAP -0.13227422568623 2.20455114585635e-06 NA NA NA hsa-miR-195-5p VANGL1 -1.07154705036962 4.16544134775761e-08 0.531484611928422 1.34603037901951e-06 mirMAP -0.224042564295357 1.13431821759058e-11 NA NA NA hsa-miR-195-5p VAV2 -1.07154705036962 4.16544134775761e-08 1.11059648576148 2.17379935908195e-13 miRNATAP -0.231448856434959 1.31995301144162e-06 23468064 Additionally miR-195 down-regulation led to increases in VAV2 and CDC42 expression which stimulated VAV2/Rac1/CDC42 signaling and lamellipodia formation and thereby facilitated the metastasis of HCC cells metastasis liver cancer hsa-miR-195-5p VEGFA -1.07154705036962 4.16544134775761e-08 0.628775505110226 0.000620913144913639 miRNAWalker2_validate;miRTarBase;MirTarget -0.293488826214044 1.3561926096363e-07 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-195-5p VPS13B -1.07154705036962 4.16544134775761e-08 0.355265011270777 0.00171278261576175 mirMAP -0.169635151935911 7.36084102184483e-07 NA NA NA hsa-miR-195-5p WBP11 -1.07154705036962 4.16544134775761e-08 0.228760845102206 0.00371548277591789 MirTarget -0.130437528234883 2.980152682955e-08 NA NA NA hsa-miR-195-5p WEE1 -1.07154705036962 4.16544134775761e-08 -0.0579007535730272 0.673440236749829 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.178028991259314 1.77025396139394e-05 22847610 Regulation of cell cycle checkpoint kinase WEE1 by miR 195 in malignant melanoma; Moreover there was an inverse correlation between the expression of WEE1 and WEE1-targeting microRNA miR-195; Further analyses showed that transfection of melanoma cell lines with miR-195 indeed reduced WEE1 mRNA and protein expression in these cells; Reporter gene analysis confirmed direct targeting of the WEE1 3' untranslated region 3'UTR by miR-195; Overexpression of miR-195 in SK-Mel-28 melanoma cells was accompanied by WEE1 reduction and significantly reduced stress-induced G2-M cell cycle arrest which could be restored by stable overexpression of WEE1; Moreover miR-195 overexpression and WEE1 knockdown respectively increased melanoma cell proliferation; Taken together the present study shows that WEE1 expression in malignant melanoma is directly regulated by miR-195 miR-195-mediated downregulation of WEE1 in metastatic lesions may help to overcome cell cycle arrest under stress conditions in the local tissue microenvironment to allow unrestricted growth of tumour cells malignant trasformation melanoma hsa-miR-195-5p WWC1 -1.07154705036962 4.16544134775761e-08 0.796945228817028 0.000310841257296447 MirTarget;miRNATAP -0.201246039375022 0.00322139763013338 NA NA NA hsa-miR-195-5p WWP1 -1.07154705036962 4.16544134775761e-08 0.182607161482234 0.0786603868716436 miRNATAP -0.141490743078785 6.1189369713502e-06 NA NA NA hsa-miR-195-5p XPO4 -1.07154705036962 4.16544134775761e-08 0.716562273066413 1.10461475888557e-09 miRNATAP -0.316750067338412 4.89985218996644e-20 NA NA NA hsa-miR-195-5p XPO7 -1.07154705036962 4.16544134775761e-08 0.262400815133265 0.00402251231845686 MirTarget;miRNATAP -0.15612123842692 1.01026035640906e-08 NA NA NA hsa-miR-195-5p YOD1 -1.07154705036962 4.16544134775761e-08 -0.0261289224682146 0.882157745947923 miRNATAP -0.261252356178582 8.22842719686754e-07 NA NA NA hsa-miR-195-5p YWHAQ -1.07154705036962 4.16544134775761e-08 -0.00973354065713039 0.900690881591244 MirTarget;miRNATAP -0.111205053185529 1.74086595049359e-06 NA NA NA hsa-miR-195-5p ZBTB33 -1.07154705036962 4.16544134775761e-08 0.742507316951897 1.77102394208059e-12 MirTarget -0.250378124236231 4.32490106506108e-15 NA NA NA hsa-miR-195-5p ZBTB34 -1.07154705036962 4.16544134775761e-08 0.206605259401183 0.035597275109861 MirTarget;miRNATAP -0.114872919683742 0.000115394936202439 NA NA NA hsa-miR-195-5p ZBTB39 -1.07154705036962 4.16544134775761e-08 0.50931556112831 1.15947134449102e-05 MirTarget;miRNATAP -0.181641724808247 2.84967129041703e-07 NA NA NA hsa-miR-195-5p ZBTB43 -1.07154705036962 4.16544134775761e-08 -0.131048868081385 0.240688437470611 miRNATAP -0.117799231180196 0.000510262768388267 NA NA NA hsa-miR-195-5p ZBTB44 -1.07154705036962 4.16544134775761e-08 0.264727540057518 0.0098977316167743 MirTarget;miRNATAP -0.158775884375268 2.64702860416675e-07 NA NA NA hsa-miR-195-5p ZBTB5 -1.07154705036962 4.16544134775761e-08 0.00482065873985693 0.96402993664477 MirTarget -0.142736184334732 8.99175982467175e-06 NA NA NA hsa-miR-195-5p ZBTB9 -1.07154705036962 4.16544134775761e-08 0.665600279602856 4.6029130590065e-10 MirTarget;miRNATAP -0.133505718310331 6.53339093879221e-05 NA NA NA hsa-miR-195-5p ZC3H13 -1.07154705036962 4.16544134775761e-08 0.294905422502363 0.0153515337103235 MirTarget -0.103686785589772 0.00539581503801592 NA NA NA hsa-miR-195-5p ZDHHC21 -1.07154705036962 4.16544134775761e-08 -0.389259000015898 0.0125589928320564 MirTarget -0.14622407680339 0.00222061952357863 NA NA NA hsa-miR-195-5p ZDHHC23 -1.07154705036962 4.16544134775761e-08 1.08894953991239 2.16182408953582e-10 MirTarget -0.358112791885925 8.52890853936669e-12 NA NA NA hsa-miR-195-5p ZKSCAN1 -1.07154705036962 4.16544134775761e-08 0.316409968255752 0.0271095118968984 MirTarget;miRNATAP -0.196812347509482 5.60206774908113e-06 NA NA NA hsa-miR-195-5p ZKSCAN2 -1.07154705036962 4.16544134775761e-08 0.327797864185555 0.0111152641237085 miRNATAP -0.146865741586308 0.000190183638343965 NA NA NA hsa-miR-195-5p ZMAT3 -1.07154705036962 4.16544134775761e-08 0.27771952020038 0.0499447683089053 MirTarget -0.114880827871447 0.00810964833291401 NA NA NA hsa-miR-195-5p ZMYM2 -1.07154705036962 4.16544134775761e-08 0.278969072922853 0.0127298205019214 MirTarget;miRNATAP -0.191745351235032 1.0236883874096e-08 NA NA NA hsa-miR-195-5p ZNF267 -1.07154705036962 4.16544134775761e-08 0.85653626241227 2.32180127051076e-15 MirTarget -0.20004379840062 4.0538672247376e-09 NA NA NA hsa-miR-195-5p ZNF280C -1.07154705036962 4.16544134775761e-08 0.906053725885801 1.25372741934245e-11 miRNAWalker2_validate -0.379684543694264 4.93004853221114e-22 NA NA NA hsa-miR-195-5p ZNF326 -1.07154705036962 4.16544134775761e-08 0.454188199393631 3.4790268196545e-06 miRNATAP -0.229003422590943 1.94577166444832e-15 NA NA NA hsa-miR-195-5p ZNF367 -1.07154705036962 4.16544134775761e-08 1.48345016913639 2.18403080237207e-19 miRNATAP -0.47447739050333 3.95146642562802e-21 NA NA NA hsa-miR-195-5p ZNF445 -1.07154705036962 4.16544134775761e-08 0.353019491783618 0.00152699832029871 mirMAP -0.136362598513462 5.90245368502659e-05 NA NA NA hsa-miR-195-5p ZNF449 -1.07154705036962 4.16544134775761e-08 0.27714056761396 0.0126076680026678 MirTarget;miRNATAP -0.120250711287166 0.000381643901789659 NA NA NA hsa-miR-195-5p ZNF621 -1.07154705036962 4.16544134775761e-08 0.327989171873721 0.000586117712565943 mirMAP -0.150139261515689 1.79551089424786e-07 NA NA NA hsa-miR-195-5p ZNF654 -1.07154705036962 4.16544134775761e-08 -0.136763612417804 0.16769732511067 MirTarget;miRNATAP -0.17197888706967 5.13793972657985e-09 NA NA NA hsa-miR-195-5p ZNF696 -1.07154705036962 4.16544134775761e-08 0.746954482312962 1.65988705190986e-12 mirMAP -0.179511504246073 5.51095618697135e-08 NA NA NA hsa-miR-195-5p ZNF697 -1.07154705036962 4.16544134775761e-08 0.93890638375053 1.51535403196417e-10 miRNATAP -0.226591155272272 7.32051239681488e-07 NA NA NA hsa-miR-195-5p ZNHIT6 -1.07154705036962 4.16544134775761e-08 0.497040349284643 2.56608406448211e-08 MirTarget -0.195524180389597 2.50347351377451e-13 NA NA NA hsa-miR-195-5p ZNRF2 -1.07154705036962 4.16544134775761e-08 0.0412398659488362 0.666276378992165 MirTarget -0.112788707738191 9.18304608406113e-05 NA NA NA