miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-192-3p ACTB -0.6401165114007 0.000266272092403814 -0.0594999724655967 0.433128836571127 MirTarget -0.114722865620584 2.28978260087367e-08 NA NA NA hsa-miR-92a-3p ACTB 0.212391012518195 0.134292268089997 -0.0594999724655967 0.433128836571127 miRNAWalker2_validate -0.103999653718267 5.81336339963721e-05 NA NA NA hsa-miR-148a-5p ACTG1 -0.767626696027761 1.08359477494797e-06 -0.122794075175761 0.20937956377109 MirTarget;miRNATAP -0.165356696033631 1.94023291301734e-08 NA NA NA hsa-miR-193b-3p ACTG1 -0.166697207281748 0.272022543069482 -0.122794075175761 0.20937956377109 miRNAWalker2_validate -0.178992968373642 7.16184725545606e-09 NA NA NA hsa-miR-103a-3p AMOT 0.765568928457606 3.05497476509383e-12 -0.89778365109471 0.000787406411317435 MirTarget -0.451268425753764 0.000108563350239157 NA NA NA hsa-miR-107 AMOT 0.241662461253461 0.0170788899505389 -0.89778365109471 0.000787406411317435 MirTarget;PITA;miRanda;miRNATAP -0.407215105104055 0.00177002515950798 NA NA NA hsa-miR-10b-3p AMOT 2.77189254628215 2.26687582932628e-20 -0.89778365109471 0.000787406411317435 mirMAP -0.137943510760411 0.00213706269739223 NA NA NA hsa-miR-16-1-3p AMOT 0.392360028038559 0.00112481918108198 -0.89778365109471 0.000787406411317435 mirMAP -0.306292471900215 0.00492624762003017 NA NA NA hsa-miR-221-3p AMOT 1.12244756358612 3.48370308238012e-13 -0.89778365109471 0.000787406411317435 miRNAWalker2_validate -0.321933225160784 9.090255444677e-05 NA NA NA hsa-miR-30d-5p AMOT 0.718283816348023 2.47422074061352e-08 -0.89778365109471 0.000787406411317435 mirMAP -0.304625289614296 0.00241374710817463 NA NA NA hsa-miR-330-5p AMOT 0.442231058604099 0.0053308560843808 -0.89778365109471 0.000787406411317435 miRanda -0.284757983872555 0.000538481461871112 NA NA NA hsa-miR-362-3p AMOT 0.814007335895913 2.00108618836568e-09 -0.89778365109471 0.000787406411317435 miRanda -0.292337752552465 0.0020771869611984 NA NA NA hsa-miR-500a-5p AMOT 0.797906382969156 9.15958171084226e-08 -0.89778365109471 0.000787406411317435 mirMAP -0.294131550099187 0.000667780819200465 NA NA NA hsa-miR-501-5p AMOT 1.15231083477882 2.98906150004088e-10 -0.89778365109471 0.000787406411317435 miRNATAP -0.291388329684638 3.00252553404814e-05 NA NA NA hsa-miR-532-5p AMOT 1.02729546510601 9.93318913966636e-16 -0.89778365109471 0.000787406411317435 MirTarget -0.371243124024762 0.00017247774856752 NA NA NA hsa-miR-618 AMOT 0.13539895350352 0.517145913114103 -0.89778365109471 0.000787406411317435 mirMAP -0.18260339716464 0.00496808373358346 NA NA NA hsa-miR-766-3p AMOT 0.199979324759329 0.257230732626744 -0.89778365109471 0.000787406411317435 MirTarget -0.359667417573805 1.04983070629406e-06 NA NA NA hsa-miR-106b-5p APC 0.648901865047099 8.24870862047885e-09 -0.178106776451097 0.0679159506996304 miRNAWalker2_validate;miRTarBase -0.152406181389829 0.000242059519728295 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells liver cancer hsa-miR-21-5p APC 1.51084295924322 1.54551622173259e-34 -0.178106776451097 0.0679159506996304 miRNAWalker2_validate -0.170963654395431 1.15664392926358e-06 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-let-7a-5p APC2 -0.328069937201898 0.000464344093744051 1.72078641102954 8.65364092042936e-19 TargetScan -0.296144411661104 0.00537712418099154 NA NA NA hsa-miR-125a-5p APC2 -0.91219969372382 1.38256246489548e-07 1.72078641102954 8.65364092042936e-19 mirMAP -0.20354523468962 0.000295443314604665 NA NA NA hsa-miR-194-3p APC2 -0.772747277805343 2.9537465170191e-05 1.72078641102954 8.65364092042936e-19 mirMAP -0.172917552309453 0.00110754915341712 NA NA NA hsa-miR-199a-5p APC2 -1.98848462405923 2.0421622713753e-11 1.72078641102954 8.65364092042936e-19 mirMAP -0.101465825144385 0.0017784302528151 NA NA NA hsa-miR-20a-3p APC2 -0.318177901603857 0.0467885456739855 1.72078641102954 8.65364092042936e-19 mirMAP -0.246153342422663 6.72022408946292e-05 NA NA NA hsa-miR-23b-5p APC2 -1.05289229952702 7.22203199173865e-13 1.72078641102954 8.65364092042936e-19 mirMAP -0.216017097324045 0.0012980633523771 NA NA NA hsa-miR-28-5p APC2 -0.430964830599964 2.67367257252925e-06 1.72078641102954 8.65364092042936e-19 mirMAP -0.301426627736638 0.00527080037286869 NA NA NA hsa-miR-505-5p APC2 -0.768282569967001 1.14662846595407e-05 1.72078641102954 8.65364092042936e-19 mirMAP -0.146052163078095 0.00923653240014872 NA NA NA hsa-miR-107 AREG 0.241662461253461 0.0170788899505389 -1.66916755239492 3.18915674348661e-06 miRanda -1.19885254866637 2.85025233054889e-12 NA NA NA hsa-miR-320a AXIN1 0.325285936317332 0.0221415065838824 0.298461396818587 0.00967766490233959 miRNAWalker2_validate -0.102922011670008 0.00946254716514405 NA NA NA hsa-miR-15b-5p AXIN2 0.230566941413564 0.0824765001857479 0.113841868770703 0.752977397700815 miRTarBase;MirTarget;miRNATAP -0.445214007102522 0.000810754926318775 NA NA NA hsa-miR-16-2-3p AXIN2 -0.0336420826463706 0.805158952566973 0.113841868770703 0.752977397700815 mirMAP -0.637896819806337 6.99346379238779e-07 NA NA NA hsa-miR-16-5p AXIN2 -0.398577235179603 0.000101598495180191 0.113841868770703 0.752977397700815 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.492511513287746 0.00421170477125135 NA NA NA hsa-miR-195-3p AXIN2 -1.09375690196245 4.70092324819807e-09 0.113841868770703 0.752977397700815 mirMAP -0.313128484413814 0.000828518151480385 NA NA NA hsa-miR-195-5p AXIN2 -1.85907534356434 1.47434041676402e-22 0.113841868770703 0.752977397700815 MirTarget;miRNATAP -0.245874041969712 0.00506110437798971 NA NA NA hsa-miR-26b-3p AXIN2 -1.25503731613309 4.45390890119649e-27 0.113841868770703 0.752977397700815 MirTarget -0.591476065389494 2.94301063245798e-05 NA NA NA hsa-miR-326 AXIN2 -1.881935132554 1.68087316863775e-21 0.113841868770703 0.752977397700815 miRanda -0.362520003418692 1.98590653589597e-05 NA NA NA hsa-miR-338-5p AXIN2 -0.221898432884726 0.252390988727086 0.113841868770703 0.752977397700815 miRNATAP -0.342154956032422 0.000172654921949776 NA NA NA hsa-miR-497-5p AXIN2 -1.41371173021948 7.09278946477743e-17 0.113841868770703 0.752977397700815 MirTarget;miRNATAP -0.294042209891213 0.00328690230713159 NA NA NA hsa-miR-616-3p AXIN2 -0.699516741506971 1.82225985970292e-05 0.113841868770703 0.752977397700815 MirTarget -0.422833368838949 7.60561180413777e-05 NA NA NA hsa-let-7a-2-3p BBC3 -1.19254913456912 1.47840144520517e-08 0.804667864310401 1.64815736901645e-10 MirTarget -0.186942417061404 1.03036799278075e-10 NA NA NA hsa-let-7g-3p BBC3 -1.14091000722297 8.32736018188759e-19 0.804667864310401 1.64815736901645e-10 MirTarget;miRNATAP -0.18136207274857 9.72621187480785e-05 NA NA NA hsa-miR-101-3p BBC3 -1.48176407980989 3.98950707385704e-31 0.804667864310401 1.64815736901645e-10 miRNATAP -0.315666699732468 1.33584521433787e-12 NA NA NA hsa-miR-125b-5p BBC3 -1.35767721102906 1.16564617395164e-18 0.804667864310401 1.64815736901645e-10 miRNAWalker2_validate;miRTarBase -0.252345623766095 4.02206333883365e-11 25184537 Thus far two of these target genes BBC3 and NEU1 that are tumor suppressor genes but not yet studied in PDAC appear to be functional targets of miR-125b since knockdown of miR125b caused their up regulation pancreatic cancer hsa-miR-139-5p BBC3 -2.11299531796557 8.16407076415038e-28 0.804667864310401 1.64815736901645e-10 miRNATAP -0.234947411363537 1.07629281857681e-15 NA NA NA hsa-miR-140-5p BBC3 -0.220106443070144 0.0140713197101242 0.804667864310401 1.64815736901645e-10 miRNATAP -0.254965831183043 0.0003006053009954 NA NA NA hsa-miR-144-3p BBC3 -2.97536914478815 6.00546047309683e-28 0.804667864310401 1.64815736901645e-10 miRNATAP -0.108503369572842 3.4984805094146e-07 NA NA NA hsa-miR-27b-3p BBC3 -0.823491817819754 9.20935302746823e-14 0.804667864310401 1.64815736901645e-10 miRNATAP -0.203869768027322 0.000220938302295931 NA NA NA hsa-miR-345-5p BBC3 -0.712725883885838 3.60393522979373e-06 0.804667864310401 1.64815736901645e-10 miRNATAP -0.16515567390068 3.92597191776169e-05 NA NA NA hsa-miR-590-3p BBC3 -0.473167498047808 1.76652934637227e-05 0.804667864310401 1.64815736901645e-10 miRanda -0.254952412597708 6.04583102362517e-06 NA NA NA hsa-let-7b-5p BIRC5 -0.959013717270803 5.95127281258643e-11 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate -0.714894665750299 6.76492235439612e-11 NA NA NA hsa-miR-101-3p BIRC5 -1.48176407980989 3.98950707385704e-31 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate -1.3265120823297 7.97415084582345e-32 NA NA NA hsa-miR-10a-5p BIRC5 -1.47723516092033 7.27299669108673e-16 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate -0.713644309178663 4.2990229259411e-17 NA NA NA hsa-miR-203a-3p BIRC5 -1.34362479226226 8.69374456831293e-05 4.49515004999251 9.61981227851246e-50 miRTarBase -0.125858297754976 0.00935408966011575 22713668;27714672 Luciferase assays were also performed to validate BIRC5 and LASP1 as miR-203 targets; Both miR-203 and BIRC5 siRNA signicantly inhibited cell proliferation in TNBC cells; Moreover up-regulated of BIRC5 and LASP1 was able to abrogate the effects induced by transfection with the miR-203 precursor;miR 203 is a predictive biomarker for colorectal cancer and its expression is associated with BIRC5; The purpose of this study was to explore the role of miR-203 in colorectal cancer CRC and evaluate the correlation between miR-203 and BIRC5; Finally miR-203 expression was negatively associated with that of BIRC5 r = -0.8150 P < 0.05 ; breast cancer;colorectal cancer hsa-miR-30c-5p BIRC5 -0.432111642767632 0.000159764714931007 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate -0.45333717178008 0.00191124919706276 NA NA NA hsa-miR-335-5p BIRC5 -1.61347836513558 1.62757083289711e-19 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate;MirTarget -0.501439997555754 1.3266718457985e-08 23232114 Genetic variation in a miR 335 binding site in BIRC5 alters susceptibility to lung cancer in Chinese Han populations; In support of the postulation that the 3' UTR SNP may directly affect miRNA-binding site reporter gene assays indicated BIRC5 was a direct target of miR-335 and the rs2239680 T>C change resulted in altered regulation of BIRC5 expression; Our findings defined a 3' UTR SNP in human BIRC5 oncogene that may increase individual susceptibility to lung cancer probably by attenuating the interaction between miR-335 and BIRC5 lung cancer hsa-miR-542-3p BIRC5 -1.31351015149842 3.64642423288576e-22 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate;MirTarget;miRanda -0.82408325426437 5.64539118201001e-13 NA NA NA hsa-miR-142-3p BMP4 -1.4243101967815 1.92609481097765e-14 0.756049865330478 0.00257381502256996 PITA;miRanda -0.207247600922499 0.00115116569048984 NA NA NA hsa-miR-130b-3p BMP6 0.687190305027546 0.000109068658562255 -1.04070882636827 2.86680404280335e-07 MirTarget -0.261586357774358 2.54168454737691e-06 NA NA NA hsa-miR-362-3p BMP6 0.814007335895913 2.00108618836568e-09 -1.04070882636827 2.86680404280335e-07 miRanda -0.295803453331868 4.29317836105299e-05 NA NA NA hsa-miR-454-3p BMP6 0.668749059573955 2.42670710515113e-06 -1.04070882636827 2.86680404280335e-07 MirTarget -0.221282179224421 0.0015666342787123 NA NA NA hsa-miR-130b-5p BMP7 0.170599813152408 0.337611586432771 0.826802462156244 0.0488671273441991 mirMAP -0.318132163788707 0.00583072092537794 NA NA NA hsa-miR-1976 BMP7 -0.431472440543166 0.00324575010550946 0.826802462156244 0.0488671273441991 MirTarget -0.453184137513286 0.0011534801443726 NA NA NA hsa-miR-22-3p BMP7 -0.628561621952407 1.33755558015523e-09 0.826802462156244 0.0488671273441991 miRNAWalker2_validate;miRTarBase -0.870526640067938 7.19988594035658e-06 NA NA NA hsa-miR-30a-5p BMP7 -0.626257932887855 0.000108198196973765 0.826802462156244 0.0488671273441991 mirMAP;miRNATAP -0.347549267695056 0.00579249244441942 NA NA NA hsa-miR-30e-5p BMP7 -0.627815042856657 3.02205690184908e-10 0.826802462156244 0.0488671273441991 mirMAP -0.577684399384162 0.00443944182643628 NA NA NA hsa-miR-34a-5p BMP7 1.03694231790865 5.74864019540594e-14 0.826802462156244 0.0488671273441991 miRNAWalker2_validate -0.454356184389064 0.00161959499114198 NA NA NA hsa-miR-616-5p BMP7 0.150569904638223 0.402836556304524 0.826802462156244 0.0488671273441991 mirMAP -0.332806313369365 0.00359782816716627 NA NA NA hsa-miR-194-3p BMP8A -0.772747277805343 2.9537465170191e-05 1.39179535627051 2.07768362972566e-10 MirTarget -0.345321516579304 1.96255802091214e-09 NA NA NA hsa-miR-30b-3p BMP8A -0.439724365151373 0.000947180503583586 1.39179535627051 2.07768362972566e-10 MirTarget -0.25070018143597 0.00221524890746471 NA NA NA hsa-miR-30e-3p BMP8A -1.20845647373031 3.10263633528203e-25 1.39179535627051 2.07768362972566e-10 MirTarget -0.31816745204753 0.000320409945817414 NA NA NA hsa-miR-455-5p BMP8A -0.270546034117157 0.0581320703577731 1.39179535627051 2.07768362972566e-10 MirTarget;miRanda -0.220675062526455 0.00398165917143642 NA NA NA hsa-miR-618 BMP8B 0.13539895350352 0.517145913114103 0.278635309161162 0.41783156155133 mirMAP -0.24421376667831 0.00327620044478589 NA NA NA hsa-miR-140-5p BMPR1A -0.220106443070144 0.0140713197101242 0.067404757264657 0.485036666167898 miRanda -0.151764440750276 0.00409272631734622 NA NA NA hsa-miR-130b-3p BMPR1B 0.687190305027546 0.000109068658562255 -3.30804269912471 8.81244453798961e-22 miRNATAP -0.344947495172456 0.000487754390390581 NA NA NA hsa-miR-140-3p BMPR1B 0.546012239205329 4.84578261098777e-11 -3.30804269912471 8.81244453798961e-22 MirTarget -1.09046911115585 1.89877766089125e-07 NA NA NA hsa-miR-362-3p BMPR1B 0.814007335895913 2.00108618836568e-09 -3.30804269912471 8.81244453798961e-22 MirTarget;miRanda -0.645914455969268 3.79800689680595e-07 NA NA NA hsa-miR-374a-5p BMPR1B 0.016390363747302 0.869784217438621 -3.30804269912471 8.81244453798961e-22 MirTarget -0.964921957092298 5.09264356359135e-08 NA NA NA hsa-miR-374b-5p BMPR1B -0.307538028546424 0.0030079617545972 -3.30804269912471 8.81244453798961e-22 MirTarget -0.450695839099619 0.00881847978065475 NA NA NA hsa-miR-106b-5p BMPR2 0.648901865047099 8.24870862047885e-09 -0.735692104466334 2.00485450351153e-12 MirTarget;miRNATAP -0.223512431560996 8.9188830870315e-07 NA NA NA hsa-miR-130b-3p BMPR2 0.687190305027546 0.000109068658562255 -0.735692104466334 2.00485450351153e-12 MirTarget;miRNATAP -0.123929624069971 2.01446000231601e-05 NA NA NA hsa-miR-148b-3p BMPR2 0.266862251671911 0.00185271302045935 -0.735692104466334 2.00485450351153e-12 mirMAP -0.274706970733769 7.21649363049453e-06 NA NA NA hsa-miR-17-5p BMPR2 0.698861147045461 2.43854106455398e-05 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.258030480679531 1.14307562421225e-17 NA NA NA hsa-miR-185-5p BMPR2 0.480006257154717 6.35758891340152e-07 -0.735692104466334 2.00485450351153e-12 MirTarget -0.248251149962323 3.7820744273094e-06 NA NA NA hsa-miR-19a-3p BMPR2 1.01712596153672 2.57753201450625e-07 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.171941398552025 1.65410472584267e-11 NA NA NA hsa-miR-19b-3p BMPR2 0.601279551368824 0.00016685097085251 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.213406658258386 2.11523139256821e-11 NA NA NA hsa-miR-20a-5p BMPR2 0.854326758727003 5.04256669663285e-07 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.240712956475078 2.24570589605185e-16 NA NA NA hsa-miR-21-5p BMPR2 1.51084295924322 1.54551622173259e-34 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;miRTarBase;MirTarget -0.284574090091544 7.19521500454622e-14 NA NA NA hsa-miR-25-3p BMPR2 0.633062563556379 3.68686354834328e-10 -0.735692104466334 2.00485450351153e-12 miRNATAP -0.165757084106315 0.00116745992362732 NA NA NA hsa-miR-29a-5p BMPR2 -0.113555908626946 0.349622266470788 -0.735692104466334 2.00485450351153e-12 mirMAP -0.147830720470257 0.00063333183931133 NA NA NA hsa-miR-301a-3p BMPR2 0.842910511640361 1.43446467417891e-06 -0.735692104466334 2.00485450351153e-12 MirTarget;miRNATAP -0.109852401653794 0.000191922548679836 NA NA NA hsa-miR-30d-5p BMPR2 0.718283816348023 2.47422074061352e-08 -0.735692104466334 2.00485450351153e-12 mirMAP -0.192680093080354 1.22378821100091e-06 NA NA NA hsa-miR-362-3p BMPR2 0.814007335895913 2.00108618836568e-09 -0.735692104466334 2.00485450351153e-12 MirTarget;PITA;miRanda;miRNATAP -0.176480837537144 2.67432279837285e-06 NA NA NA hsa-miR-455-5p BMPR2 -0.270546034117157 0.0581320703577731 -0.735692104466334 2.00485450351153e-12 PITA -0.128605088499673 0.000444129926379739 NA NA NA hsa-miR-532-5p BMPR2 1.02729546510601 9.93318913966636e-16 -0.735692104466334 2.00485450351153e-12 PITA -0.287474341863181 7.79954625495596e-14 NA NA NA hsa-miR-590-5p BMPR2 -0.103355559980404 0.310027295317092 -0.735692104466334 2.00485450351153e-12 MirTarget;PITA;miRNATAP -0.192437141753484 0.000199081821262727 NA NA NA hsa-miR-618 BMPR2 0.13539895350352 0.517145913114103 -0.735692104466334 2.00485450351153e-12 PITA;mirMAP -0.104710045816621 4.93634023271714e-05 NA NA NA hsa-miR-671-5p BMPR2 0.843645373345787 3.92794196273313e-08 -0.735692104466334 2.00485450351153e-12 miRNATAP -0.105325283608643 0.00170736830794517 NA NA NA hsa-miR-769-5p BMPR2 0.219661452072771 0.0333425465750576 -0.735692104466334 2.00485450351153e-12 miRNATAP -0.151503783690954 0.00299663761326287 NA NA NA hsa-miR-877-5p BMPR2 1.35669625926821 1.43008125755656e-11 -0.735692104466334 2.00485450351153e-12 MirTarget -0.152834848664501 5.00642626283946e-09 NA NA NA hsa-miR-92a-3p BMPR2 0.212391012518195 0.134292268089997 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;miRNATAP -0.242426688195997 2.09632606862697e-11 NA NA NA hsa-miR-93-3p BMPR2 0.402821129107592 0.00131324842735588 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate -0.19142388334342 3.75720841597008e-06 NA NA NA hsa-miR-93-5p BMPR2 1.39518349670953 2.84167728726712e-25 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.270878794921134 3.0942354684122e-14 NA NA NA hsa-miR-15b-5p BTRC 0.230566941413564 0.0824765001857479 -0.00218074865097106 0.976713248009905 MirTarget;miRNATAP -0.123880101738054 4.9294638073766e-06 NA NA NA hsa-miR-16-5p BTRC -0.398577235179603 0.000101598495180191 -0.00218074865097106 0.976713248009905 miRNAWalker2_validate;MirTarget;miRNATAP -0.170550874702878 1.08874294937544e-06 NA NA NA hsa-miR-193a-3p BTRC -0.117675551589896 0.309391958208578 -0.00218074865097106 0.976713248009905 MirTarget;miRanda -0.149422822918282 1.65168232460744e-06 NA NA NA hsa-miR-193b-3p BTRC -0.166697207281748 0.272022543069482 -0.00218074865097106 0.976713248009905 miRNAWalker2_validate -0.163000762742341 2.75522541287735e-12 NA NA NA hsa-miR-361-3p BTRC 0.275658012727111 0.00549374744374488 -0.00218074865097106 0.976713248009905 MirTarget;PITA;miRNATAP -0.103082226711992 0.00494622838999385 NA NA NA hsa-miR-497-5p BTRC -1.41371173021948 7.09278946477743e-17 -0.00218074865097106 0.976713248009905 MirTarget;miRNATAP -0.112851166430765 2.51720614567891e-08 NA NA NA hsa-miR-505-3p BTRC -1.20027021591555 1.27927500175937e-13 -0.00218074865097106 0.976713248009905 MirTarget -0.125291265362961 4.21412050838456e-09 NA NA NA hsa-miR-106a-5p CCND1 -0.464229535269236 0.009724944358047 -0.901747452525989 1.22363850855738e-05 MirTarget;miRNATAP -0.262282596122017 2.76721397734651e-06 NA NA NA hsa-miR-106b-5p CCND1 0.648901865047099 8.24870862047885e-09 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.430796355484411 1.07010119372681e-06 NA NA NA hsa-miR-1266-5p CCND1 1.6344248374643 4.09278929749906e-13 -0.901747452525989 1.22363850855738e-05 MirTarget -0.234489057674296 5.64471200142146e-08 NA NA NA hsa-miR-15b-5p CCND1 0.230566941413564 0.0824765001857479 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.544455359613115 3.17021042565567e-13 NA NA NA hsa-miR-16-5p CCND1 -0.398577235179603 0.000101598495180191 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.309506657035983 0.00178218906910022 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-17-5p CCND1 0.698861147045461 2.43854106455398e-05 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.343463418912801 9.97512783987264e-09 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-186-5p CCND1 -0.060103391373687 0.535288717081205 -0.901747452525989 1.22363850855738e-05 mirMAP -0.315936974513477 0.00286438511586306 NA NA NA hsa-miR-19a-3p CCND1 1.01712596153672 2.57753201450625e-07 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.283475432466515 1.38758823633513e-08 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 -0.277804782598538 0.0783067794722916 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase -0.307712037252966 1.4364183273616e-06 NA NA NA hsa-miR-19b-3p CCND1 0.601279551368824 0.00016685097085251 -0.901747452525989 1.22363850855738e-05 miRNATAP -0.340975400639976 4.6454998539434e-08 NA NA NA hsa-miR-20a-5p CCND1 0.854326758727003 5.04256669663285e-07 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.332506713675419 1.04479750525145e-08 NA NA NA hsa-miR-20b-5p CCND1 0.457668023910379 0.0285865211936156 -0.901747452525989 1.22363850855738e-05 MirTarget;miRNATAP -0.230429652941375 1.603682834845e-06 NA NA NA hsa-miR-340-5p CCND1 -0.00477614531381576 0.968502722773791 -0.901747452525989 1.22363850855738e-05 mirMAP -0.322810275002772 0.000125999869952101 NA NA NA hsa-miR-425-5p CCND1 0.585974239943864 2.23063410931402e-05 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate -0.385144136522737 9.38557217850495e-08 NA NA NA hsa-miR-503-5p CCND1 0.191949282338049 0.268420664548092 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.155187994375291 0.00815133470022587 26047605;23731275 MiR 503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression; Overexpression of miR-503 in breast cancer cell lines reduced cell proliferation through inducing G0/G1 cell cycle arrest by targeting CCND1;MicroRNA 503 suppresses proliferation and cell cycle progression of endometrioid endometrial cancer by negatively regulating cyclin D1; CCND1 has a binding sequence of miR-503 within its 3' untranslated region and was confirmed to be a direct target of miR-503 by the fluorescent reporter assays; Increasing the miR-503 level in EEC cells suppressed cell viability colon formation activity and cell-cycle progression and the inhibited oncogenic phenotypes induced by miR-503 were alleviated by ectopic expression of CCND1 without the untranslated region sequence; Collectively this study suggested that miR-503 plays a tumor-suppressor role by targeting CCND1; Abnormal suppression of miR-503 leads to an increase in the CCND1 level which may promote carcinogenesis and progression of EEC ;progression;tumorigenesis breast cancer;endometrial cancer hsa-miR-589-3p CCND1 1.16846704028095 5.88525574424201e-11 -0.901747452525989 1.22363850855738e-05 MirTarget -0.183119037529565 0.00124255651400669 NA NA NA hsa-miR-616-5p CCND1 0.150569904638223 0.402836556304524 -0.901747452525989 1.22363850855738e-05 mirMAP -0.256039244652268 5.24430962347992e-06 NA NA NA hsa-miR-7-1-3p CCND1 -0.569105143287799 1.85297665041424e-05 -0.901747452525989 1.22363850855738e-05 mirMAP -0.260985322289835 0.000573950021646959 NA NA NA hsa-miR-9-5p CCND1 1.26407994492898 8.53156156439881e-05 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate -0.136746717035529 1.04306605002938e-05 NA NA NA hsa-miR-92a-3p CCND1 0.212391012518195 0.134292268089997 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate -0.407898716180535 8.06773614790968e-09 NA NA NA hsa-miR-93-5p CCND1 1.39518349670953 2.84167728726712e-25 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.335918242999821 2.01286203755089e-06 NA NA NA hsa-miR-942-5p CCND1 0.346451845105263 0.0283255399972342 -0.901747452525989 1.22363850855738e-05 MirTarget -0.245807225430864 0.000123103109119178 NA NA NA hsa-miR-130b-5p CCND2 0.170599813152408 0.337611586432771 0.356451160382274 0.0365641518216489 mirMAP -0.174593683703476 0.000182311423622 NA NA NA hsa-miR-20a-5p CCND2 0.854326758727003 5.04256669663285e-07 0.356451160382274 0.0365641518216489 miRNAWalker2_validate;miRTarBase;miRNATAP -0.156120931730772 0.0012098497067071 NA NA NA hsa-miR-28-5p CCND2 -0.430964830599964 2.67367257252925e-06 0.356451160382274 0.0365641518216489 miRanda -0.482733599739849 7.0104175669049e-08 NA NA NA hsa-miR-33a-3p CCND2 -0.683025859637737 1.01106097756419e-05 0.356451160382274 0.0365641518216489 MirTarget -0.263538375258973 6.17940317063527e-07 NA NA NA hsa-miR-3607-3p CCND2 -2.15518588554493 1.03390728226728e-23 0.356451160382274 0.0365641518216489 mirMAP -0.12362922199284 0.000700039964538526 NA NA NA hsa-miR-378a-3p CCND2 -1.1920055906972 3.23538871733634e-10 0.356451160382274 0.0365641518216489 miRNAWalker2_validate -0.183441253857915 1.70039721501862e-05 NA NA NA hsa-miR-548v CCND2 -0.27258775900243 0.176259917595269 0.356451160382274 0.0365641518216489 MirTarget -0.149460521918892 0.000339780804187451 NA NA NA hsa-miR-616-5p CCND2 0.150569904638223 0.402836556304524 0.356451160382274 0.0365641518216489 mirMAP -0.315443515897926 3.35063962863299e-12 NA NA NA hsa-miR-618 CCND2 0.13539895350352 0.517145913114103 0.356451160382274 0.0365641518216489 mirMAP -0.225947558771367 2.79586020953898e-08 NA NA NA hsa-miR-27b-3p CCND3 -0.823491817819754 9.20935302746823e-14 0.0767102129984094 0.478427267753328 miRNAWalker2_validate -0.236832359235505 2.50262257150465e-07 NA NA NA hsa-miR-320a CCND3 0.325285936317332 0.0221415065838824 0.0767102129984094 0.478427267753328 miRanda -0.118523664136384 0.00134906533817398 NA NA NA hsa-miR-146b-5p CDH1 0.419719546795449 0.0457375823220155 -0.925620688902025 3.54334396234e-05 miRanda -0.209827116364557 5.56204266800899e-05 NA NA NA hsa-miR-185-5p CDH1 0.480006257154717 6.35758891340152e-07 -0.925620688902025 3.54334396234e-05 MirTarget -0.447644587025903 7.92400318750844e-05 27212161;24025511 We also found that ectopic expression of miR-185 reversed EMT via the up-regulation of E-cadherin and down-regulation of vimentin in epithelial and mesenchymal HCC cells;After transfection of miR-185 inhibitor into KYSE30 the expression of E-cadherin a downstream protein of Six1 was observed under confocal microscope; After transfection of miR-185 inhibitorthe expression level of E-cadherin decreased ; liver cancer;esophageal cancer hsa-let-7b-5p CSNK1D -0.959013717270803 5.95127281258643e-11 0.4731959867792 3.43904217952384e-13 miRNAWalker2_validate -0.191856445994201 1.75913960457771e-20 NA NA NA hsa-miR-29a-3p CSNK1D -0.856762511178136 4.65330336378459e-12 0.4731959867792 3.43904217952384e-13 mirMAP -0.139652188260037 3.22631524237687e-08 NA NA NA hsa-miR-29c-3p CSNK1D -1.4367517608807 1.61767774905781e-21 0.4731959867792 3.43904217952384e-13 mirMAP -0.153963096922558 8.21998200113075e-15 NA NA NA hsa-miR-148a-5p CSNK1E -0.767626696027761 1.08359477494797e-06 0.608336779934033 9.56780795613581e-12 miRNATAP -0.245152102120518 4.84178312131527e-20 NA NA NA hsa-miR-195-3p CSNK1E -1.09375690196245 4.70092324819807e-09 0.608336779934033 9.56780795613581e-12 miRNATAP -0.104078083921822 9.86380539775099e-06 NA NA NA hsa-miR-140-5p CTNNA1 -0.220106443070144 0.0140713197101242 0.477481972401709 8.87542250578207e-13 miRanda -0.101108060082385 0.00711815401125459 NA NA NA hsa-miR-197-3p CTNNA1 -0.245033899783728 0.0362223947695203 0.477481972401709 8.87542250578207e-13 MirTarget -0.118337035802743 3.15979587202152e-05 NA NA NA hsa-miR-542-3p CTNNA1 -1.31351015149842 3.64642423288576e-22 0.477481972401709 8.87542250578207e-13 miRanda -0.148898664848693 7.27961563781666e-11 NA NA NA hsa-miR-590-3p CTNNA1 -0.473167498047808 1.76652934637227e-05 0.477481972401709 8.87542250578207e-13 miRanda -0.130130643170941 1.37988484935611e-05 NA NA NA hsa-miR-142-3p CTNNA2 -1.4243101967815 1.92609481097765e-14 2.25787302460162 0.000155826635136281 miRanda -0.627113560365015 3.57921163798015e-05 NA NA NA hsa-miR-183-5p CTNNA2 2.33444328833177 1.52188109365421e-10 2.25787302460162 0.000155826635136281 MirTarget;miRNATAP -0.267080612735119 0.00064396812606403 NA NA NA hsa-miR-199a-3p CTNNA2 -2.3279328685682 1.04468066198593e-17 2.25787302460162 0.000155826635136281 MirTarget -0.521228083201561 3.46304846039583e-07 NA NA NA hsa-miR-199b-3p CTNNA2 -2.33226605401203 9.51887435273314e-18 2.25787302460162 0.000155826635136281 MirTarget -0.521575116257334 3.33225244965853e-07 NA NA NA hsa-miR-375 CTNNA2 -1.93190458972328 4.28108492522e-06 2.25787302460162 0.000155826635136281 miRanda -0.536758758213988 7.27294766012571e-16 NA NA NA hsa-miR-381-3p CTNNA2 -1.11307533852141 4.70760087251745e-06 2.25787302460162 0.000155826635136281 MirTarget -0.365522435354208 0.00213698380843069 NA NA NA hsa-miR-450b-5p CTNNA2 -1.34333360369432 2.68386079790462e-17 2.25787302460162 0.000155826635136281 miRNATAP -0.628722579887348 0.000386672999199392 NA NA NA hsa-miR-628-3p CTNNA2 -0.958478775877672 6.18965095549213e-08 2.25787302460162 0.000155826635136281 PITA -0.506400102187758 0.00223666117535717 NA NA NA hsa-miR-885-5p CTNNA2 -0.940994379567566 0.00118729865914986 2.25787302460162 0.000155826635136281 PITA;miRNATAP -0.584370851965426 3.28232022031145e-09 NA NA NA hsa-miR-146b-5p CTNNA3 0.419719546795449 0.0457375823220155 -2.93718508917758 1.13925248568176e-18 miRanda -0.226544923718825 0.00498984553126637 NA NA NA hsa-miR-21-3p CTNNA3 -0.484219378716006 0.00299941098417659 -2.93718508917758 1.13925248568176e-18 MirTarget -0.407566699322434 8.0112613537227e-05 NA NA NA hsa-miR-330-5p CTNNA3 0.442231058604099 0.0053308560843808 -2.93718508917758 1.13925248568176e-18 miRanda -0.629788966021321 2.03096891231877e-09 NA NA NA hsa-miR-421 CTNNA3 0.941856334694081 6.12167297054077e-08 -2.93718508917758 1.13925248568176e-18 miRanda -0.565666571289945 2.5646098632998e-09 NA NA NA hsa-miR-940 CTNNA3 0.453020092551484 0.0177054921651997 -2.93718508917758 1.13925248568176e-18 MirTarget -0.268196473897404 0.00331837480917266 NA NA NA hsa-miR-330-3p CTNNB1 -0.332364259424489 0.0316051913061459 0.00180452674840392 0.983564078864382 MirTarget;PITA;miRNATAP -0.128940103294471 3.76576237893285e-06 NA NA NA hsa-miR-331-3p CTNNB1 -0.283974346994635 0.0373785411053202 0.00180452674840392 0.983564078864382 miRNAWalker2_validate -0.113207881387487 0.000273720190926097 NA NA NA hsa-miR-21-5p DLG1 1.51084295924322 1.54551622173259e-34 -0.138873477942219 0.0841159694184806 miRNAWalker2_validate -0.189341396834391 3.40040140631564e-11 NA NA NA hsa-miR-324-5p DLG1 0.372933276649782 0.00592280066108904 -0.138873477942219 0.0841159694184806 miRanda -0.100307323016796 0.000481882548935351 NA NA NA hsa-miR-1301-3p DLG2 1.12156714169769 4.22404125385203e-10 -1.94736926226419 3.34813832074824e-14 MirTarget -0.438823376721358 2.24849336661338e-10 NA NA NA hsa-miR-148b-3p DLG2 0.266862251671911 0.00185271302045935 -1.94736926226419 3.34813832074824e-14 miRNAWalker2_validate;MirTarget -0.405392755440987 0.00789509139320608 NA NA NA hsa-miR-148b-5p DLG2 0.295777213389605 0.0255749859535438 -1.94736926226419 3.34813832074824e-14 mirMAP -0.387127343063427 7.25442055867567e-05 NA NA NA hsa-miR-15b-3p DLG2 0.238105490431193 0.0997721500357416 -1.94736926226419 3.34813832074824e-14 mirMAP -0.370183431562009 3.29702422674737e-05 NA NA NA hsa-miR-17-5p DLG2 0.698861147045461 2.43854106455398e-05 -1.94736926226419 3.34813832074824e-14 mirMAP -0.414581649711475 6.02115525810022e-08 NA NA NA hsa-miR-182-5p DLG2 1.96601340710222 4.39326175603633e-09 -1.94736926226419 3.34813832074824e-14 miRNATAP -0.102326912137778 0.00679899154112103 NA NA NA hsa-miR-185-5p DLG2 0.480006257154717 6.35758891340152e-07 -1.94736926226419 3.34813832074824e-14 MirTarget;miRNATAP -0.585001218896104 1.08558613918031e-05 NA NA NA hsa-miR-19a-3p DLG2 1.01712596153672 2.57753201450625e-07 -1.94736926226419 3.34813832074824e-14 mirMAP -0.22650959029035 0.000436287749207939 NA NA NA hsa-miR-19b-3p DLG2 0.601279551368824 0.00016685097085251 -1.94736926226419 3.34813832074824e-14 mirMAP -0.227850181928977 0.00467340085902087 NA NA NA hsa-miR-20a-5p DLG2 0.854326758727003 5.04256669663285e-07 -1.94736926226419 3.34813832074824e-14 mirMAP -0.365285100773836 9.13655135441683e-07 NA NA NA hsa-miR-25-3p DLG2 0.633062563556379 3.68686354834328e-10 -1.94736926226419 3.34813832074824e-14 mirMAP -0.642887617125935 2.75162968877984e-07 NA NA NA hsa-miR-30d-5p DLG2 0.718283816348023 2.47422074061352e-08 -1.94736926226419 3.34813832074824e-14 miRNATAP -0.363773642468621 0.000231815120160987 NA NA NA hsa-miR-3127-5p DLG2 0.837385386388614 2.06679743975142e-07 -1.94736926226419 3.34813832074824e-14 mirMAP -0.439847961137459 1.83598868919462e-08 NA NA NA hsa-miR-32-3p DLG2 0.219109440121582 0.207217051619543 -1.94736926226419 3.34813832074824e-14 mirMAP;miRNATAP -0.218972155689991 0.00446036942484243 NA NA NA hsa-miR-338-3p DLG2 0.543135607704581 0.00461167747143826 -1.94736926226419 3.34813832074824e-14 PITA;mirMAP;miRNATAP -0.258027700886022 0.000116642109610452 NA NA NA hsa-miR-361-5p DLG2 0.233202959858696 0.00961572812255327 -1.94736926226419 3.34813832074824e-14 miRanda;mirMAP -0.570334322796734 7.93845041599148e-05 NA NA NA hsa-miR-421 DLG2 0.941856334694081 6.12167297054077e-08 -1.94736926226419 3.34813832074824e-14 miRanda -0.518100901641586 4.72344152852429e-13 NA NA NA hsa-miR-590-5p DLG2 -0.103355559980404 0.310027295317092 -1.94736926226419 3.34813832074824e-14 PITA;miRanda -0.482030758851427 0.000164242719150219 NA NA NA hsa-miR-769-3p DLG2 0.618139013155289 0.000147293288426878 -1.94736926226419 3.34813832074824e-14 PITA;miRNATAP -0.311568922342203 0.000111866459567808 NA NA NA hsa-miR-769-5p DLG2 0.219661452072771 0.0333425465750576 -1.94736926226419 3.34813832074824e-14 miRNATAP -0.614300914468782 9.08721044557608e-07 NA NA NA hsa-miR-877-5p DLG2 1.35669625926821 1.43008125755656e-11 -1.94736926226419 3.34813832074824e-14 MirTarget -0.425138597726373 3.76095774744139e-11 NA NA NA hsa-miR-93-3p DLG2 0.402821129107592 0.00131324842735588 -1.94736926226419 3.34813832074824e-14 MirTarget;miRNATAP -0.545495539293013 8.74222185854571e-08 NA NA NA hsa-miR-940 DLG2 0.453020092551484 0.0177054921651997 -1.94736926226419 3.34813832074824e-14 MirTarget;PITA;miRNATAP -0.194693896485225 0.00516311256170128 NA NA NA hsa-miR-125b-2-3p DLG3 -1.6609436107315 5.71534047969855e-18 -0.329967827327226 0.199885371190668 mirMAP -0.211224356784511 0.000723475074360306 NA NA NA hsa-miR-374a-5p DLG3 0.016390363747302 0.869784217438621 -0.329967827327226 0.199885371190668 MirTarget -0.499587850995381 7.70531611872268e-05 NA NA NA hsa-miR-374b-5p DLG3 -0.307538028546424 0.0030079617545972 -0.329967827327226 0.199885371190668 MirTarget -0.491318016800149 4.94192652827619e-05 NA NA NA hsa-miR-885-5p DLG3 -0.940994379567566 0.00118729865914986 -0.329967827327226 0.199885371190668 PITA;miRNATAP -0.143811586329677 0.00078833677558364 NA NA NA hsa-miR-107 DLG4 0.241662461253461 0.0170788899505389 -0.146949641519714 0.251213701507925 PITA;miRanda;miRNATAP -0.162166466183531 0.00891866369823292 NA NA NA hsa-miR-122-5p DLG4 -1.23907441373955 4.42181244888642e-06 -0.146949641519714 0.251213701507925 miRNATAP -0.144599915750752 9.44438240174641e-11 NA NA NA hsa-miR-616-5p DLG4 0.150569904638223 0.402836556304524 -0.146949641519714 0.251213701507925 MirTarget;miRNATAP -0.134966429391631 9.64579138194613e-05 NA NA NA hsa-miR-10a-5p DVL1 -1.47723516092033 7.27299669108673e-16 0.0974490868963773 0.351327376305342 miRNAWalker2_validate -0.122692252559585 3.72861974540746e-06 NA NA NA hsa-miR-27a-3p DVL2 -0.370807380415112 0.00875721956202713 0.932937814675565 4.78146420278758e-20 miRNATAP -0.102448960625914 0.00526923611599277 NA NA NA hsa-miR-27b-3p DVL2 -0.823491817819754 9.20935302746823e-14 0.932937814675565 4.78146420278758e-20 miRNATAP -0.221394297021235 1.09073127725023e-06 NA NA NA hsa-miR-125b-5p DVL3 -1.35767721102906 1.16564617395164e-18 0.609321698955873 3.59083763972193e-15 miRNATAP -0.128110031624996 8.52754629911134e-08 NA NA NA hsa-miR-26b-5p DVL3 -1.10804856399744 4.14176110314282e-22 0.609321698955873 3.59083763972193e-15 miRNAWalker2_validate -0.111951369829111 0.000527706771327525 NA NA NA hsa-miR-29b-2-5p DVL3 -0.223258653034772 0.084306146519938 0.609321698955873 3.59083763972193e-15 MirTarget -0.104468815670416 0.000526336007952701 NA NA NA hsa-miR-16-1-3p FBXW11 0.392360028038559 0.00112481918108198 0.0471132174286888 0.541930794061236 MirTarget -0.108794263042156 0.000448893797575061 NA NA NA hsa-miR-16-1-3p FGF1 0.392360028038559 0.00112481918108198 -0.678542882304208 0.00654328337233827 mirMAP -0.418480509125599 3.32517568843891e-05 NA NA NA hsa-miR-186-5p FGF1 -0.060103391373687 0.535288717081205 -0.678542882304208 0.00654328337233827 mirMAP -0.41367102247344 0.00114927327556726 NA NA NA hsa-miR-18a-5p FGF1 0.918028187958706 1.90229510425322e-05 -0.678542882304208 0.00654328337233827 MirTarget -0.257554404550762 3.95122313648269e-06 NA NA NA hsa-miR-361-5p FGF1 0.233202959858696 0.00961572812255327 -0.678542882304208 0.00654328337233827 miRanda -0.510174670094289 0.000185533193035221 NA NA NA hsa-miR-550a-5p FGF1 0.156224023171823 0.282505553619229 -0.678542882304208 0.00654328337233827 MirTarget -0.374323243103714 7.86437510357121e-06 NA NA NA hsa-miR-576-5p FGF1 -0.377452008285847 0.00470735657343984 -0.678542882304208 0.00654328337233827 PITA;mirMAP -0.266396057997619 0.00356602502679197 NA NA NA hsa-miR-590-5p FGF1 -0.103355559980404 0.310027295317092 -0.678542882304208 0.00654328337233827 MirTarget;miRanda;miRNATAP -0.467961306585168 0.000104595555173684 NA NA NA hsa-miR-106b-5p FRMD6 0.648901865047099 8.24870862047885e-09 -1.21152640864769 5.47511255884304e-11 MirTarget;miRNATAP -0.241566046298854 0.00284435790614935 NA NA NA hsa-miR-148a-5p FRMD6 -0.767626696027761 1.08359477494797e-06 -1.21152640864769 5.47511255884304e-11 miRNATAP -0.265946601036678 3.72552484847375e-06 NA NA NA hsa-miR-17-5p FRMD6 0.698861147045461 2.43854106455398e-05 -1.21152640864769 5.47511255884304e-11 MirTarget;TargetScan;miRNATAP -0.257660134139753 2.57717646896967e-06 NA NA NA hsa-miR-20a-5p FRMD6 0.854326758727003 5.04256669663285e-07 -1.21152640864769 5.47511255884304e-11 MirTarget;miRNATAP -0.279756250197403 1.25931771546973e-07 NA NA NA hsa-miR-362-3p FRMD6 0.814007335895913 2.00108618836568e-09 -1.21152640864769 5.47511255884304e-11 miRanda;miRNATAP -0.206446134920954 0.0019980920719301 NA NA NA hsa-miR-618 FRMD6 0.13539895350352 0.517145913114103 -1.21152640864769 5.47511255884304e-11 MirTarget -0.228524762338858 4.4330557066832e-07 NA NA NA hsa-miR-93-5p FRMD6 1.39518349670953 2.84167728726712e-25 -1.21152640864769 5.47511255884304e-11 MirTarget;miRNATAP -0.341299435454836 9.68294512347244e-08 NA NA NA hsa-miR-146b-5p FZD1 0.419719546795449 0.0457375823220155 -0.990655512447529 2.10933438723933e-07 MirTarget;PITA;miRanda -0.181547752240403 4.76064172222519e-05 NA NA NA hsa-miR-192-5p FZD1 -0.50188499512787 0.00344713341196035 -0.990655512447529 2.10933438723933e-07 miRNAWalker2_validate -0.45834591686859 3.50571643482894e-18 NA NA NA hsa-miR-204-5p FZD1 -0.537962150012103 0.0330895493358849 -0.990655512447529 2.10933438723933e-07 miRNAWalker2_validate;miRTarBase -0.191287702204747 2.21232709468904e-07 NA NA NA hsa-miR-616-5p FZD1 0.150569904638223 0.402836556304524 -0.990655512447529 2.10933438723933e-07 mirMAP -0.158227006984694 0.00265078035674632 NA NA NA hsa-miR-107 FZD10 0.241662461253461 0.0170788899505389 1.18521144835282 0.000162683525329498 miRanda -0.685702388495361 6.84052605459746e-06 NA NA NA hsa-miR-15a-5p FZD10 0.349521211668244 0.000770735998804736 1.18521144835282 0.000162683525329498 miRNATAP -0.438409856444815 0.003263536270437 NA NA NA hsa-miR-455-3p FZD10 -1.3998033821095 5.72010709806871e-17 1.18521144835282 0.000162683525329498 PITA;miRNATAP -0.56334164531716 9.62780657403636e-11 NA NA NA hsa-miR-885-5p FZD10 -0.940994379567566 0.00118729865914986 1.18521144835282 0.000162683525329498 miRNATAP -0.13685072159518 0.00962492070890173 NA NA NA hsa-miR-616-5p FZD2 0.150569904638223 0.402836556304524 0.407208233535239 0.0755693801228699 MirTarget -0.338122672996804 3.93516371913571e-08 NA NA NA hsa-miR-107 FZD3 0.241662461253461 0.0170788899505389 -0.431602727356764 0.0760494397449049 MirTarget;miRanda -0.328401554754828 0.0054060803500497 NA NA NA hsa-miR-130b-3p FZD3 0.687190305027546 0.000109068658562255 -0.431602727356764 0.0760494397449049 mirMAP -0.223724254155923 0.000730162697139419 NA NA NA hsa-miR-148a-5p FZD3 -0.767626696027761 1.08359477494797e-06 -0.431602727356764 0.0760494397449049 mirMAP -0.211739463838664 0.00451119062120206 NA NA NA hsa-miR-17-5p FZD3 0.698861147045461 2.43854106455398e-05 -0.431602727356764 0.0760494397449049 MirTarget;TargetScan;mirMAP;miRNATAP -0.236272506444877 0.000871018931823823 NA NA NA hsa-miR-19a-3p FZD3 1.01712596153672 2.57753201450625e-07 -0.431602727356764 0.0760494397449049 mirMAP -0.18311268282731 0.00197585182551426 NA NA NA hsa-miR-19b-3p FZD3 0.601279551368824 0.00016685097085251 -0.431602727356764 0.0760494397449049 mirMAP -0.24031433694887 0.00112634324256369 NA NA NA hsa-miR-20a-5p FZD3 0.854326758727003 5.04256669663285e-07 -0.431602727356764 0.0760494397449049 MirTarget;mirMAP;miRNATAP -0.263395197675831 0.000124585706310954 NA NA NA hsa-miR-30b-3p FZD3 -0.439724365151373 0.000947180503583586 -0.431602727356764 0.0760494397449049 MirTarget -0.24731920299484 0.00552723242526519 NA NA NA hsa-miR-30d-5p FZD3 0.718283816348023 2.47422074061352e-08 -0.431602727356764 0.0760494397449049 MirTarget;miRNATAP -0.251555607321146 0.00569090251961539 NA NA NA hsa-miR-30e-5p FZD3 -0.627815042856657 3.02205690184908e-10 -0.431602727356764 0.0760494397449049 MirTarget -0.313017658821363 0.00780190229296611 NA NA NA hsa-miR-361-5p FZD3 0.233202959858696 0.00961572812255327 -0.431602727356764 0.0760494397449049 miRanda;miRNATAP -0.462237677798914 0.000503688852257815 NA NA NA hsa-miR-374a-5p FZD3 0.016390363747302 0.869784217438621 -0.431602727356764 0.0760494397449049 mirMAP -0.515684566089532 1.54619533499017e-05 NA NA NA hsa-miR-374b-5p FZD3 -0.307538028546424 0.0030079617545972 -0.431602727356764 0.0760494397449049 mirMAP -0.314879611306133 0.00623855042899404 NA NA NA hsa-miR-618 FZD3 0.13539895350352 0.517145913114103 -0.431602727356764 0.0760494397449049 mirMAP -0.153943038668687 0.00893723937598839 NA NA NA hsa-miR-106b-5p FZD4 0.648901865047099 8.24870862047885e-09 -0.346477770504521 0.0109747315056824 miRNATAP -0.36533974993703 1.76820222419432e-10 NA NA NA hsa-miR-132-3p FZD4 0.323796239695997 0.00272093067935091 -0.346477770504521 0.0109747315056824 mirMAP -0.197762210860301 0.00135588231940112 NA NA NA hsa-miR-17-3p FZD4 0.410352776142368 0.00422200500748636 -0.346477770504521 0.0109747315056824 MirTarget -0.252002356659912 3.55104649644788e-08 NA NA NA hsa-miR-17-5p FZD4 0.698861147045461 2.43854106455398e-05 -0.346477770504521 0.0109747315056824 TargetScan -0.299061948789719 9.79518944458252e-15 NA NA NA hsa-miR-185-5p FZD4 0.480006257154717 6.35758891340152e-07 -0.346477770504521 0.0109747315056824 MirTarget -0.200083841875822 0.00363439169236857 NA NA NA hsa-miR-20a-5p FZD4 0.854326758727003 5.04256669663285e-07 -0.346477770504521 0.0109747315056824 miRNATAP -0.232364507622619 9.13182947842467e-10 NA NA NA hsa-miR-21-5p FZD4 1.51084295924322 1.54551622173259e-34 -0.346477770504521 0.0109747315056824 mirMAP -0.321725677881532 3.91700387140416e-11 NA NA NA hsa-miR-301a-3p FZD4 0.842910511640361 1.43446467417891e-06 -0.346477770504521 0.0109747315056824 mirMAP -0.250733852712318 8.69861743307876e-12 NA NA NA hsa-miR-3127-5p FZD4 0.837385386388614 2.06679743975142e-07 -0.346477770504521 0.0109747315056824 MirTarget -0.176968510712896 1.23416560759146e-05 NA NA NA hsa-miR-32-3p FZD4 0.219109440121582 0.207217051619543 -0.346477770504521 0.0109747315056824 mirMAP -0.121464026837635 0.00213277900393597 NA NA NA hsa-miR-32-5p FZD4 0.0806126674664016 0.548984992497432 -0.346477770504521 0.0109747315056824 mirMAP -0.154053517461878 0.00191026430922297 NA NA NA hsa-miR-324-3p FZD4 0.260348469146494 0.0506141704203545 -0.346477770504521 0.0109747315056824 miRNATAP -0.334268099452611 8.51422936858383e-12 NA NA NA hsa-miR-330-5p FZD4 0.442231058604099 0.0053308560843808 -0.346477770504521 0.0109747315056824 miRanda;miRNATAP -0.179393591072445 1.5890828802521e-05 NA NA NA hsa-miR-454-3p FZD4 0.668749059573955 2.42670710515113e-06 -0.346477770504521 0.0109747315056824 mirMAP -0.23311646427779 3.96330467330486e-07 NA NA NA hsa-miR-484 FZD4 0.0857240033709656 0.453982056282229 -0.346477770504521 0.0109747315056824 PITA -0.188977225347998 0.00122538887414835 NA NA NA hsa-miR-589-3p FZD4 1.16846704028095 5.88525574424201e-11 -0.346477770504521 0.0109747315056824 mirMAP -0.139392746188407 0.000169124779133096 NA NA NA hsa-miR-590-5p FZD4 -0.103355559980404 0.310027295317092 -0.346477770504521 0.0109747315056824 mirMAP -0.202339454029402 0.00215050890915688 NA NA NA hsa-miR-629-3p FZD4 -0.315338123880353 0.119091248294946 -0.346477770504521 0.0109747315056824 miRNATAP -0.180168798456347 6.64540825121219e-08 NA NA NA hsa-miR-92a-3p FZD4 0.212391012518195 0.134292268089997 -0.346477770504521 0.0109747315056824 mirMAP -0.269272307477207 6.07485388868062e-09 NA NA NA hsa-miR-940 FZD4 0.453020092551484 0.0177054921651997 -0.346477770504521 0.0109747315056824 miRNATAP -0.132263443170156 0.000207893541211134 NA NA NA hsa-miR-155-5p FZD5 0.0108524225071784 0.95651331033505 -0.369296645507686 0.00193987461810255 miRNATAP -0.108901572202147 0.000190892447770734 NA NA NA hsa-miR-22-5p FZD5 -0.630365901263172 3.32415348030414e-05 -0.369296645507686 0.00193987461810255 mirMAP -0.135763345615629 0.000350175467115029 NA NA NA hsa-miR-23a-3p FZD5 -0.178875974460574 0.135978273540604 -0.369296645507686 0.00193987461810255 miRNATAP -0.221775183749934 4.71150652459033e-06 NA NA NA hsa-miR-342-3p FZD5 -0.319677314984262 0.0449813878317147 -0.369296645507686 0.00193987461810255 PITA -0.145780735296127 6.11633847456932e-05 NA NA NA hsa-miR-101-3p FZD6 -1.48176407980989 3.98950707385704e-31 0.589500198001939 0.00374127878510925 miRNAWalker2_validate;MirTarget -0.312670748498135 1.38907823475328e-05 NA NA NA hsa-miR-139-5p FZD6 -2.11299531796557 8.16407076415038e-28 0.589500198001939 0.00374127878510925 miRanda -0.171390807110702 0.00034847427750895 NA NA NA hsa-miR-194-5p FZD6 -0.292530160992458 0.0996141384876663 0.589500198001939 0.00374127878510925 MirTarget -0.265420163621645 1.75074747054336e-06 NA NA NA hsa-miR-455-5p FZD6 -0.270546034117157 0.0581320703577731 0.589500198001939 0.00374127878510925 miRanda -0.230555626016252 0.000940179578305785 NA NA NA hsa-miR-130b-5p FZD7 0.170599813152408 0.337611586432771 -0.284533887049024 0.256557978536031 mirMAP -0.282002555419828 3.7625719536306e-05 NA NA NA hsa-miR-192-5p FZD7 -0.50188499512787 0.00344713341196035 -0.284533887049024 0.256557978536031 miRNAWalker2_validate -0.59446912784293 2.96084223842181e-18 NA NA NA hsa-miR-215-5p FZD7 -0.981544773246509 3.14452272477156e-05 -0.284533887049024 0.256557978536031 miRNAWalker2_validate -0.176488344117398 0.00056453629652869 NA NA NA hsa-miR-30c-1-3p FZD7 -1.39373825444537 6.39912952911454e-17 -0.284533887049024 0.256557978536031 MirTarget -0.242705306431575 0.000670205498648697 NA NA NA hsa-miR-486-5p FZD7 -1.77766890600022 2.9071717929922e-14 -0.284533887049024 0.256557978536031 miRanda -0.198992007637947 7.59438109490878e-05 NA NA NA hsa-miR-616-5p FZD7 0.150569904638223 0.402836556304524 -0.284533887049024 0.256557978536031 mirMAP -0.181379407562843 0.00784556160013837 NA NA NA hsa-miR-362-3p FZD8 0.814007335895913 2.00108618836568e-09 -1.21039879054975 2.52210905797718e-08 miRanda -0.247656870244882 0.00149588487455642 NA NA NA hsa-miR-374b-5p FZD8 -0.307538028546424 0.0030079617545972 -1.21039879054975 2.52210905797718e-08 miRNAWalker2_validate -0.276231840355344 0.0082320939699218 NA NA NA hsa-miR-192-5p FZD9 -0.50188499512787 0.00344713341196035 -0.243785341556497 0.505341223526538 miRNATAP -0.306354280194544 0.00309846297489247 NA NA NA hsa-miR-148a-3p GDF6 -0.748702855596996 3.93313343865641e-07 -2.10139054692363 1.01669881798518e-11 miRNATAP -0.327974606729441 0.00151705432220982 NA NA NA hsa-miR-324-5p GDF6 0.372933276649782 0.00592280066108904 -2.10139054692363 1.01669881798518e-11 miRanda -0.3280163006671 0.00405331751922112 NA NA NA hsa-miR-532-3p GDF6 0.297601533259956 0.014632205884815 -2.10139054692363 1.01669881798518e-11 PITA;miRNATAP -0.562088337736992 8.64759385655773e-06 NA NA NA hsa-miR-589-3p GDF6 1.16846704028095 5.88525574424201e-11 -2.10139054692363 1.01669881798518e-11 MirTarget -0.263843974926024 0.00226413038643534 NA NA NA hsa-miR-197-3p GDF7 -0.245033899783728 0.0362223947695203 -1.70565631034897 1.45352939577227e-07 miRNAWalker2_validate -0.652312246172849 1.84706393928919e-06 NA NA NA hsa-miR-224-3p GDF7 1.40770116795301 1.31426607144612e-08 -1.70565631034897 1.45352939577227e-07 mirMAP -0.33032138163421 2.19235580868161e-07 NA NA NA hsa-miR-502-5p GDF7 0.892373335336396 1.7122694518919e-06 -1.70565631034897 1.45352939577227e-07 mirMAP -0.285883912037438 0.000979251400949544 NA NA NA hsa-miR-10b-3p GLI2 2.77189254628215 2.26687582932628e-20 -1.14224882795575 0.000293659575288629 MirTarget -0.281899035840983 7.67842644714296e-08 NA NA NA hsa-miR-33a-3p GLI2 -0.683025859637737 1.01106097756419e-05 -1.14224882795575 0.000293659575288629 MirTarget -0.3706427588808 0.00018235189350555 NA NA NA hsa-miR-502-3p GLI2 0.659598854007546 3.01316453996423e-08 -1.14224882795575 0.000293659575288629 MirTarget;miRNATAP -0.332379614333684 0.00983401038916764 NA NA NA hsa-miR-29b-3p GSK3B -0.348885528720517 0.0121441341291285 0.11314223970595 0.0774493616232908 miRTarBase;miRNATAP -0.106852381323571 1.32787261855633e-06 NA NA NA hsa-miR-342-3p GSK3B -0.319677314984262 0.0449813878317147 0.11314223970595 0.0774493616232908 miRanda -0.106989468297279 2.44530655156687e-08 NA NA NA hsa-miR-103a-3p ID2 0.765568928457606 3.05497476509383e-12 -1.61066414419896 4.81945990305561e-27 miRNAWalker2_validate;miRTarBase -0.312121729027969 6.10447032095761e-06 NA NA NA hsa-miR-21-5p LATS1 1.51084295924322 1.54551622173259e-34 -0.730797585786345 4.24866694321044e-05 miRNAWalker2_validate -0.259052381224193 7.34088380250575e-05 25769949 miR 21 modulates resistance of HR HPV positive cervical cancer cells to radiation through targeting LATS1; By using dual luciferase assay we verified a binding site between miR-21 and 3'-UTR of large tumor suppressor kinase 1 LATS1; Through direct binding miR-21 can regulate LATS1 expression in cervical cancer cells; LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment drug resistance cervical and endocervical cancer hsa-miR-30d-3p LATS1 -0.120562286038759 0.329549534782125 -0.730797585786345 4.24866694321044e-05 mirMAP -0.231899217977241 0.00114281465472615 NA NA NA hsa-miR-103a-3p LATS2 0.765568928457606 3.05497476509383e-12 -0.854512611498505 6.73437920843447e-12 miRNATAP -0.229992052302244 3.1613590604333e-05 27602163 Furthermore miR-103 repressed large tumor suppressor kinase 2 LATS2 expression by directly binding to the LATS2-3'-untranslated region and an inverse correlation was identified between the expression of miR-103 and LATS2 messenger RNA in primary CRC tissues; In summary miR-103 performs a critical role in the promotion of the invasive and metastatic capacities of CRC possibly by directly targeting LATS2 colorectal cancer hsa-miR-130b-5p LATS2 0.170599813152408 0.337611586432771 -0.854512611498505 6.73437920843447e-12 miRNATAP -0.133987672499182 0.000122824425431265 NA NA NA hsa-miR-140-3p LATS2 0.546012239205329 4.84578261098777e-11 -0.854512611498505 6.73437920843447e-12 miRNATAP -0.34700814311033 2.48709099182699e-06 NA NA NA hsa-miR-15b-5p LATS2 0.230566941413564 0.0824765001857479 -0.854512611498505 6.73437920843447e-12 miRNATAP -0.134311315035021 0.00429872641323736 NA NA NA hsa-miR-188-5p LATS2 1.11646899351496 9.56686958408598e-11 -0.854512611498505 6.73437920843447e-12 PITA -0.145302485388362 3.62212021114557e-05 NA NA NA hsa-miR-25-3p LATS2 0.633062563556379 3.68686354834328e-10 -0.854512611498505 6.73437920843447e-12 miRNATAP -0.360174709506795 1.7426164581492e-09 25179841 MiR 25 promotes ovarian cancer proliferation and motility by targeting LATS2; Large tumor suppressor 2 LATS2 a tumor suppressor was confirmed to be a direct target of miR-25 in OC cells; Moreover restoration of LATS2 significantly attenuated the oncogenic effects of miR-25 motility ovarian cancer hsa-miR-362-3p LATS2 0.814007335895913 2.00108618836568e-09 -0.854512611498505 6.73437920843447e-12 PITA;miRanda -0.204198155141594 5.08172078895738e-06 NA NA NA hsa-miR-92a-3p LATS2 0.212391012518195 0.134292268089997 -0.854512611498505 6.73437920843447e-12 miRNATAP -0.223003422459293 3.02251637325321e-07 NA NA NA hsa-miR-93-5p LATS2 1.39518349670953 2.84167728726712e-25 -0.854512611498505 6.73437920843447e-12 miRNAWalker2_validate -0.348309570330753 1.4911736699014e-16 NA NA NA hsa-let-7a-3p LEF1 -0.568717557554068 1.00947202557819e-07 2.65801616612257 2.07740338608884e-15 miRNATAP -0.639538499404186 4.40051133869843e-05 NA NA NA hsa-let-7b-3p LEF1 -1.21979213547786 5.84575581584603e-17 2.65801616612257 2.07740338608884e-15 miRNATAP -0.67397556538713 8.7442482981614e-10 NA NA NA hsa-miR-193b-3p LEF1 -0.166697207281748 0.272022543069482 2.65801616612257 2.07740338608884e-15 miRNAWalker2_validate -0.526045563134031 2.1073127312606e-06 NA NA NA hsa-miR-217 LEF1 1.05797297540381 0.0401026692682422 2.65801616612257 2.07740338608884e-15 miRanda -0.105257516400941 0.00126797400951558 NA NA NA hsa-miR-26a-5p LEF1 -0.963792031426845 1.83360999387345e-22 2.65801616612257 2.07740338608884e-15 miRNATAP -0.92158550768103 1.12073884009285e-08 NA NA NA hsa-miR-26b-5p LEF1 -1.10804856399744 4.14176110314282e-22 2.65801616612257 2.07740338608884e-15 miRNATAP -0.884181051978605 1.54988692872715e-10 24785257 miR26b is downregulated in several cancers and tumors and miR26b directly targets the lymphoid enhancer factor 1 Lef13'UTR and inhibits endogenous Lef1 expression; We report that miR26b expression is associated with human colon cancer through the regulation of LEF1 expression in colon cancer cells; Analyses of multiple colon cancer cell lines revealed an inverse correlation between miR26b and LEF1 expression; Normal human colon cells express low levels of LEF1 and high levels of miR26b; however human colon cancer cells have decreased miR26b expression and increased LEF1 expression; We demonstrate that miR26b expression is a potent inhibitor of colon cancer cell proliferation and significantly decreases LEF1 expression; Analyses of human colon cancer databases also demonstrated a link between miR26b and LEF1 expression colon cancer hsa-miR-3065-3p LEF1 -1.04244468016704 4.60743424372577e-05 2.65801616612257 2.07740338608884e-15 miRNATAP -0.274446867079685 2.50754901313177e-05 NA NA NA hsa-miR-326 LEF1 -1.881935132554 1.68087316863775e-21 2.65801616612257 2.07740338608884e-15 miRanda -0.385522349171234 2.19966753424773e-06 NA NA NA hsa-miR-33a-3p LEF1 -0.683025859637737 1.01106097756419e-05 2.65801616612257 2.07740338608884e-15 miRNATAP -0.438284453346108 5.04525548190065e-05 NA NA NA hsa-miR-455-5p LEF1 -0.270546034117157 0.0581320703577731 2.65801616612257 2.07740338608884e-15 miRanda -0.352774280915771 0.00297563964985378 NA NA NA hsa-miR-590-3p LEF1 -0.473167498047808 1.76652934637227e-05 2.65801616612257 2.07740338608884e-15 PITA;miRanda;mirMAP -0.434383824253157 0.00459273011390873 NA NA NA hsa-miR-7-1-3p LEF1 -0.569105143287799 1.85297665041424e-05 2.65801616612257 2.07740338608884e-15 mirMAP -0.451164571544049 0.000354486807433584 NA NA NA hsa-miR-132-3p LIMD1 0.323796239695997 0.00272093067935091 0.242601733850809 0.0190447425498849 mirMAP -0.174395926009479 0.000187337688040687 NA NA NA hsa-miR-146a-5p LIMD1 -0.742958238440575 0.000765983177482633 0.242601733850809 0.0190447425498849 mirMAP -0.125293595298433 2.13163126213186e-08 NA NA NA hsa-miR-155-5p LIMD1 0.0108524225071784 0.95651331033505 0.242601733850809 0.0190447425498849 mirMAP -0.105375288187533 2.91661389855801e-05 NA NA NA hsa-miR-23a-3p LIMD1 -0.178875974460574 0.135978273540604 0.242601733850809 0.0190447425498849 mirMAP -0.148870262953196 0.00041213730295288 NA NA NA hsa-miR-330-3p LIMD1 -0.332364259424489 0.0316051913061459 0.242601733850809 0.0190447425498849 MirTarget;mirMAP -0.142420487245541 1.73935139182708e-05 NA NA NA hsa-miR-342-3p LIMD1 -0.319677314984262 0.0449813878317147 0.242601733850809 0.0190447425498849 MirTarget;miRanda -0.115877133923826 0.000237255735182647 NA NA NA hsa-miR-542-3p LIMD1 -1.31351015149842 3.64642423288576e-22 0.242601733850809 0.0190447425498849 miRanda;mirMAP -0.112501169147696 0.00142939821591583 NA NA NA hsa-miR-139-5p LLGL1 -2.11299531796557 8.16407076415038e-28 0.947565653523109 2.51534195296859e-14 miRNATAP -0.216974577338777 1.5789148033507e-13 NA NA NA hsa-miR-142-3p LLGL2 -1.4243101967815 1.92609481097765e-14 0.383389491262816 0.000723782011805506 PITA;miRanda;miRNATAP -0.174095584931647 8.12566070680843e-10 NA NA NA hsa-miR-146b-3p LLGL2 -1.20799545896423 2.19859530890688e-09 0.383389491262816 0.000723782011805506 miRNATAP -0.123390778902875 3.84376422262309e-06 NA NA NA hsa-miR-155-5p MPP5 0.0108524225071784 0.95651331033505 -0.288077654324143 0.00156212311296768 miRNAWalker2_validate;MirTarget -0.110442087685103 6.02471832816348e-07 NA NA NA hsa-miR-181a-5p MPP5 0.250113435902954 0.0551933249319293 -0.288077654324143 0.00156212311296768 MirTarget -0.201571449433359 2.04181329475018e-09 NA NA NA hsa-miR-181b-5p MPP5 0.488256489401108 0.00105321129419701 -0.288077654324143 0.00156212311296768 MirTarget -0.186364240958831 1.66154880493207e-10 NA NA NA hsa-miR-181c-5p MPP5 -0.00639394152050299 0.969127212255928 -0.288077654324143 0.00156212311296768 MirTarget -0.166932885838278 2.84704999321177e-10 NA NA NA hsa-miR-181d-5p MPP5 0.161600964883517 0.363806828762999 -0.288077654324143 0.00156212311296768 MirTarget -0.136403268251933 3.25169290945595e-08 NA NA NA hsa-miR-21-5p MPP5 1.51084295924322 1.54551622173259e-34 -0.288077654324143 0.00156212311296768 miRNAWalker2_validate -0.261426709918366 3.95335462458201e-16 NA NA NA hsa-miR-23a-3p MPP5 -0.178875974460574 0.135978273540604 -0.288077654324143 0.00156212311296768 MirTarget -0.1795478607726 1.15218447753626e-06 NA NA NA hsa-miR-330-5p MPP5 0.442231058604099 0.0053308560843808 -0.288077654324143 0.00156212311296768 PITA;miRanda -0.149342760887266 6.3096020549515e-08 NA NA NA hsa-miR-338-3p MPP5 0.543135607704581 0.00461167747143826 -0.288077654324143 0.00156212311296768 miRanda -0.104423598541063 5.24641523469875e-06 NA NA NA hsa-miR-590-5p MPP5 -0.103355559980404 0.310027295317092 -0.288077654324143 0.00156212311296768 miRanda -0.175085841217758 6.6579976861416e-05 NA NA NA hsa-miR-93-3p MPP5 0.402821129107592 0.00131324842735588 -0.288077654324143 0.00156212311296768 miRNAWalker2_validate -0.100313323845415 0.00466661098709339 NA NA NA hsa-miR-423-5p MYC 0.698807775906485 1.02195196334612e-11 -1.53204423111148 3.53987625613016e-10 miRNAWalker2_validate -0.328206409340035 0.00484551582134482 NA NA NA hsa-miR-10a-5p NF2 -1.47723516092033 7.27299669108673e-16 0.664388802089412 1.31735413428132e-13 miRNAWalker2_validate -0.101691757278488 1.52653047457592e-05 NA NA NA hsa-miR-140-5p NF2 -0.220106443070144 0.0140713197101242 0.664388802089412 1.31735413428132e-13 miRanda -0.212063071464743 2.61343065772092e-05 NA NA NA hsa-miR-16-5p NF2 -0.398577235179603 0.000101598495180191 0.664388802089412 1.31735413428132e-13 MirTarget -0.128530847499247 0.00341452299633831 NA NA NA hsa-miR-195-5p NF2 -1.85907534356434 1.47434041676402e-22 0.664388802089412 1.31735413428132e-13 MirTarget -0.153750864300167 1.89528376118971e-12 NA NA NA hsa-miR-29c-3p NF2 -1.4367517608807 1.61767774905781e-21 0.664388802089412 1.31735413428132e-13 mirMAP -0.158125558632293 1.55838293866251e-08 NA NA NA hsa-miR-424-5p NF2 -2.62653257498508 2.38997974737991e-50 0.664388802089412 1.31735413428132e-13 MirTarget -0.145592003132911 4.15703392984433e-11 NA NA NA hsa-miR-497-5p NF2 -1.41371173021948 7.09278946477743e-17 0.664388802089412 1.31735413428132e-13 MirTarget -0.126641976126094 5.42083033441122e-07 NA NA NA hsa-miR-542-3p NF2 -1.31351015149842 3.64642423288576e-22 0.664388802089412 1.31735413428132e-13 MirTarget -0.137590568710479 1.10336945644302e-05 NA NA NA hsa-miR-200b-3p NKD1 -1.29335788099229 0.000268623234305059 0.620599204750343 0.186026311634854 TargetScan -0.177575800556816 0.00545052296927983 NA NA NA hsa-miR-24-3p NKD1 -0.257825594021966 0.00689742600215061 0.620599204750343 0.186026311634854 miRNAWalker2_validate -0.720087685375527 0.00289253594101155 NA NA NA hsa-miR-326 NKD1 -1.881935132554 1.68087316863775e-21 0.620599204750343 0.186026311634854 miRanda -0.457719741066059 3.39632756723267e-05 NA NA NA hsa-miR-330-5p NKD1 0.442231058604099 0.0053308560843808 0.620599204750343 0.186026311634854 miRanda;miRNATAP -0.798011342105715 1.8924968824333e-08 NA NA NA hsa-miR-340-5p NKD1 -0.00477614531381576 0.968502722773791 0.620599204750343 0.186026311634854 mirMAP -0.497913166437519 0.00902117405267133 NA NA NA hsa-miR-501-5p NKD1 1.15231083477882 2.98906150004088e-10 0.620599204750343 0.186026311634854 mirMAP -0.34471849546258 0.00491783464284498 NA NA NA hsa-miR-125a-3p PARD6A -0.841683158494395 3.51202687176603e-05 -0.366864442169253 0.0288593342501624 miRanda -0.107642678985653 0.00842509256257783 NA NA NA hsa-let-7c-5p PARD6B -1.70744661345097 2.87934212005942e-20 -0.0933903062942685 0.430333811242109 MirTarget -0.142218447562304 1.26822558335396e-06 NA NA NA hsa-miR-140-5p PARD6B -0.220106443070144 0.0140713197101242 -0.0933903062942685 0.430333811242109 miRanda -0.250434390372293 0.00010794766386295 NA NA NA hsa-miR-374a-5p PARD6B 0.016390363747302 0.869784217438621 -0.0933903062942685 0.430333811242109 MirTarget;mirMAP -0.206286596898999 0.000382950056825018 NA NA NA hsa-miR-125b-5p PPP1CA -1.35767721102906 1.16564617395164e-18 0.303022930555886 0.000109120513182489 miRTarBase -0.111950791232314 2.12974815561444e-06 25240408 MiR 125b promotes cell migration and invasion by targeting PPP1CA Rb signal pathways in gastric cancer resulting in a poor prognosis; MiR-125b was upregulated in gastric cancer tissues and cell lines and significantly promoted cellular proliferation migration and invasion by downregulating the expression of PPP1CA and upregulating Rb phosphorylation; MiR-125b functions as an oncogene by targeting downregulated PPP1CA and upregulated Rb phosphorylation in gastric cancer worse prognosis;cell migration gastric cancer hsa-miR-140-3p PPP1CB 0.546012239205329 4.84578261098777e-11 -0.113089181371475 0.070517400699001 miRNATAP -0.10930303316636 0.00244669627639863 NA NA NA hsa-miR-455-5p PPP1CB -0.270546034117157 0.0581320703577731 -0.113089181371475 0.070517400699001 PITA;miRanda -0.108589825999147 2.28031215864973e-07 NA NA NA hsa-let-7a-3p PPP1CC -0.568717557554068 1.00947202557819e-07 0.49737777455741 2.71927608312891e-12 mirMAP -0.137378746175003 2.71770997326194e-05 NA NA NA hsa-let-7b-3p PPP1CC -1.21979213547786 5.84575581584603e-17 0.49737777455741 2.71927608312891e-12 mirMAP -0.196765497954377 2.11352445922222e-18 NA NA NA hsa-let-7g-3p PPP1CC -1.14091000722297 8.32736018188759e-19 0.49737777455741 2.71927608312891e-12 miRNATAP -0.148185927896111 1.23879215836641e-08 NA NA NA hsa-miR-140-5p PPP1CC -0.220106443070144 0.0140713197101242 0.49737777455741 2.71927608312891e-12 PITA;miRanda;miRNATAP -0.103243777340449 0.00985582101839192 NA NA NA hsa-miR-26a-5p PPP1CC -0.963792031426845 1.83360999387345e-22 0.49737777455741 2.71927608312891e-12 miRNAWalker2_validate -0.154736404556753 5.36021947710792e-06 NA NA NA hsa-miR-26b-5p PPP1CC -1.10804856399744 4.14176110314282e-22 0.49737777455741 2.71927608312891e-12 miRNAWalker2_validate -0.152800622679302 1.57461710000263e-07 NA NA NA hsa-miR-27b-3p PPP1CC -0.823491817819754 9.20935302746823e-14 0.49737777455741 2.71927608312891e-12 miRNATAP -0.13676023941215 1.07893706554136e-05 NA NA NA hsa-miR-30a-5p PPP1CC -0.626257932887855 0.000108198196973765 0.49737777455741 2.71927608312891e-12 miRNAWalker2_validate -0.150676324834665 1.26487356161985e-12 NA NA NA hsa-miR-450b-5p PPP1CC -1.34333360369432 2.68386079790462e-17 0.49737777455741 2.71927608312891e-12 PITA -0.137672429388089 5.67210960848535e-11 NA NA NA hsa-miR-421 PPP2CB 0.941856334694081 6.12167297054077e-08 -0.890331286940364 2.58768297455211e-18 miRNAWalker2_validate;miRanda -0.107091673318932 0.000264470518633695 NA NA NA hsa-miR-425-5p PPP2CB 0.585974239943864 2.23063410931402e-05 -0.890331286940364 2.58768297455211e-18 miRNAWalker2_validate -0.210079108287547 1.06195847865028e-08 NA NA NA hsa-miR-940 PPP2CB 0.453020092551484 0.0177054921651997 -0.890331286940364 2.58768297455211e-18 MirTarget;PITA -0.108413768942713 9.39010367602326e-05 NA NA NA hsa-miR-16-5p PPP2R1A -0.398577235179603 0.000101598495180191 0.434617655824211 2.19736728815959e-07 miRNAWalker2_validate -0.16156782548915 5.72423585631049e-05 NA NA NA hsa-miR-505-5p PPP2R1A -0.768282569967001 1.14662846595407e-05 0.434617655824211 2.19736728815959e-07 miRNAWalker2_validate -0.101132276982143 1.32519884220096e-05 NA NA NA hsa-miR-15b-5p PPP2R1B 0.230566941413564 0.0824765001857479 -0.366373279268895 0.0120240053013953 MirTarget -0.166547119923006 0.0019576167364681 NA NA NA hsa-miR-30b-5p PPP2R1B -0.54056186708617 2.44688760798341e-05 -0.366373279268895 0.0120240053013953 miRNATAP -0.174282215186143 0.00161533222972509 NA NA NA hsa-miR-30d-3p PPP2R1B -0.120562286038759 0.329549534782125 -0.366373279268895 0.0120240053013953 mirMAP -0.172420555072298 0.00291249897697552 NA NA NA hsa-miR-744-3p PPP2R1B -0.866026958622846 2.43034431433797e-08 -0.366373279268895 0.0120240053013953 MirTarget -0.151341218126979 0.000790301774844116 NA NA NA hsa-miR-106b-5p PPP2R2A 0.648901865047099 8.24870862047885e-09 -0.893386744728836 1.42691109729952e-19 MirTarget;miRNATAP -0.200118143024595 4.95341178091498e-06 NA NA NA hsa-miR-140-3p PPP2R2A 0.546012239205329 4.84578261098777e-11 -0.893386744728836 1.42691109729952e-19 PITA -0.164635101330579 0.0061294672647094 NA NA NA hsa-miR-17-5p PPP2R2A 0.698861147045461 2.43854106455398e-05 -0.893386744728836 1.42691109729952e-19 MirTarget;TargetScan;miRNATAP -0.118338916789628 7.95994648130442e-05 NA NA NA hsa-miR-20a-5p PPP2R2A 0.854326758727003 5.04256669663285e-07 -0.893386744728836 1.42691109729952e-19 MirTarget;miRNATAP -0.124111638240801 1.90528354769801e-05 NA NA NA hsa-miR-425-5p PPP2R2A 0.585974239943864 2.23063410931402e-05 -0.893386744728836 1.42691109729952e-19 MirTarget;miRNATAP -0.174560086210021 1.11318996260443e-06 NA NA NA hsa-miR-92a-3p PPP2R2A 0.212391012518195 0.134292268089997 -0.893386744728836 1.42691109729952e-19 miRNAWalker2_validate -0.102694235878115 0.00387764819688652 NA NA NA hsa-miR-93-5p PPP2R2A 1.39518349670953 2.84167728726712e-25 -0.893386744728836 1.42691109729952e-19 MirTarget;miRNATAP -0.188170128446582 6.86080187206839e-08 NA NA NA hsa-miR-126-5p PPP2R2B -0.428561469405594 6.6035585844222e-05 -0.319661735361422 0.283871715863449 MirTarget -0.411398178777023 0.00235203877837632 NA NA NA hsa-miR-192-5p PPP2R2C -0.50188499512787 0.00344713341196035 2.04406049288738 0.000156223168786157 mirMAP -0.907229698394586 2.29871744989232e-09 NA NA NA hsa-miR-194-5p PPP2R2C -0.292530160992458 0.0996141384876663 2.04406049288738 0.000156223168786157 miRNATAP -0.955546890731209 7.00101635982174e-11 NA NA NA hsa-miR-140-3p PPP2R2D 0.546012239205329 4.84578261098777e-11 -0.387206987580826 2.38322021549683e-07 mirMAP -0.144421486678596 0.00101270301665515 NA NA NA hsa-miR-126-5p PRKCI -0.428561469405594 6.6035585844222e-05 0.255083279807259 0.00440156138299662 mirMAP -0.156939025146708 0.000105369029657472 NA NA NA hsa-miR-29a-5p PRKCI -0.113555908626946 0.349622266470788 0.255083279807259 0.00440156138299662 mirMAP -0.111970950102542 0.00195351479266156 NA NA NA hsa-miR-30b-3p PRKCI -0.439724365151373 0.000947180503583586 0.255083279807259 0.00440156138299662 MirTarget -0.153130037535598 2.45842138313672e-06 NA NA NA hsa-miR-664a-3p PRKCI 0.485807855553031 0.000732553249798598 0.255083279807259 0.00440156138299662 mirMAP -0.128161495840541 2.04155809156129e-05 NA NA NA hsa-miR-582-5p PRKCZ -0.680189083316822 0.00103755166534107 -0.58350786340066 0.0160618792724641 MirTarget;PITA -0.172060889538547 0.00253107304013545 NA NA NA hsa-miR-542-3p RASSF1 -1.31351015149842 3.64642423288576e-22 0.655816117151532 9.89885092178326e-16 miRanda -0.10263601023261 0.000356102220108548 NA NA NA hsa-miR-106b-5p RASSF6 0.648901865047099 8.24870862047885e-09 -0.748768474661194 0.0102981957577591 mirMAP -0.425799051756173 0.000659758395307013 NA NA NA hsa-miR-130b-3p RASSF6 0.687190305027546 0.000109068658562255 -0.748768474661194 0.0102981957577591 mirMAP -0.252666468801598 0.00152176480299891 NA NA NA hsa-miR-130b-5p RASSF6 0.170599813152408 0.337611586432771 -0.748768474661194 0.0102981957577591 mirMAP -0.211170087220365 0.00860137543714371 NA NA NA hsa-miR-140-3p RASSF6 0.546012239205329 4.84578261098777e-11 -0.748768474661194 0.0102981957577591 MirTarget -0.735203021690634 1.40548641697277e-05 NA NA NA hsa-miR-16-1-3p RASSF6 0.392360028038559 0.00112481918108198 -0.748768474661194 0.0102981957577591 mirMAP -0.437664343698695 0.00021183907758793 NA NA NA hsa-miR-17-3p RASSF6 0.410352776142368 0.00422200500748636 -0.748768474661194 0.0102981957577591 MirTarget -0.479397024124286 1.13425422392804e-06 NA NA NA hsa-miR-17-5p RASSF6 0.698861147045461 2.43854106455398e-05 -0.748768474661194 0.0102981957577591 mirMAP -0.411859707482279 1.15555177759887e-06 NA NA NA hsa-miR-20a-5p RASSF6 0.854326758727003 5.04256669663285e-07 -0.748768474661194 0.0102981957577591 mirMAP -0.416341562516064 3.8189794404351e-07 NA NA NA hsa-miR-25-3p RASSF6 0.633062563556379 3.68686354834328e-10 -0.748768474661194 0.0102981957577591 mirMAP -0.49790155092848 0.000344253781395415 NA NA NA hsa-miR-32-3p RASSF6 0.219109440121582 0.207217051619543 -0.748768474661194 0.0102981957577591 mirMAP -0.220249878464934 0.00957495419518115 NA NA NA hsa-miR-32-5p RASSF6 0.0806126674664016 0.548984992497432 -0.748768474661194 0.0102981957577591 mirMAP -0.362769966517552 0.000649543899579019 NA NA NA hsa-miR-33a-3p RASSF6 -0.683025859637737 1.01106097756419e-05 -0.748768474661194 0.0102981957577591 MirTarget -0.269510155816567 0.00324348473882773 NA NA NA hsa-miR-361-5p RASSF6 0.233202959858696 0.00961572812255327 -0.748768474661194 0.0102981957577591 miRanda -0.442178249664559 0.00577183715653038 NA NA NA hsa-miR-374a-5p RASSF6 0.016390363747302 0.869784217438621 -0.748768474661194 0.0102981957577591 MirTarget -0.481120904179282 0.000841422006532807 NA NA NA hsa-miR-374b-5p RASSF6 -0.307538028546424 0.0030079617545972 -0.748768474661194 0.0102981957577591 MirTarget -0.406323295454572 0.00330958992762737 NA NA NA hsa-miR-532-5p RASSF6 1.02729546510601 9.93318913966636e-16 -0.748768474661194 0.0102981957577591 MirTarget -0.613239917190813 8.10577762031746e-09 NA NA NA hsa-miR-92a-3p RASSF6 0.212391012518195 0.134292268089997 -0.748768474661194 0.0102981957577591 mirMAP -0.471710081440704 2.42709683012518e-06 NA NA NA hsa-miR-93-5p RASSF6 1.39518349670953 2.84167728726712e-25 -0.748768474661194 0.0102981957577591 mirMAP -0.417232447347186 2.82699621375529e-05 NA NA NA hsa-miR-103a-3p SAV1 0.765568928457606 3.05497476509383e-12 -0.727133761112071 2.14795464927526e-10 miRNAWalker2_validate -0.257007500319152 3.29844786787271e-07 NA NA NA hsa-miR-421 SAV1 0.941856334694081 6.12167297054077e-08 -0.727133761112071 2.14795464927526e-10 miRanda -0.186927881962504 4.57694317136225e-09 NA NA NA hsa-miR-193b-3p SCRIB -0.166697207281748 0.272022543069482 1.238156581703 6.96733151079396e-24 miRNAWalker2_validate -0.139672284452342 0.000835866362017363 NA NA NA hsa-miR-148a-5p SERPINE1 -0.767626696027761 1.08359477494797e-06 -2.5626204615753 1.45202766560285e-19 miRNATAP -0.260590457035894 0.00415058434081855 NA NA NA hsa-miR-30d-5p SERPINE1 0.718283816348023 2.47422074061352e-08 -2.5626204615753 1.45202766560285e-19 miRNATAP -0.510774042367725 3.44422983628064e-06 NA NA NA hsa-miR-34a-5p SERPINE1 1.03694231790865 5.74864019540594e-14 -2.5626204615753 1.45202766560285e-19 miRNATAP -0.399999110948681 8.04313907897335e-05 NA NA NA hsa-miR-17-5p SMAD1 0.698861147045461 2.43854106455398e-05 -0.766119082328572 3.17324503519034e-10 TargetScan -0.271438450894389 1.28614752715314e-14 NA NA NA hsa-miR-30d-5p SMAD1 0.718283816348023 2.47422074061352e-08 -0.766119082328572 3.17324503519034e-10 miRNAWalker2_validate;miRTarBase -0.164510281478173 0.000382736580996914 NA NA NA hsa-miR-421 SMAD1 0.941856334694081 6.12167297054077e-08 -0.766119082328572 3.17324503519034e-10 PITA;miRanda -0.204012492922758 1.7229707263226e-09 NA NA NA hsa-miR-589-3p SMAD1 1.16846704028095 5.88525574424201e-11 -0.766119082328572 3.17324503519034e-10 MirTarget -0.222094662072 2.14494232480849e-11 NA NA NA hsa-miR-590-5p SMAD1 -0.103355559980404 0.310027295317092 -0.766119082328572 3.17324503519034e-10 miRanda -0.273958507619009 4.4256713892777e-06 NA NA NA hsa-miR-455-5p SMAD2 -0.270546034117157 0.0581320703577731 0.315604980822302 9.76507196938151e-07 miRanda -0.126014730396316 7.82261975485323e-09 NA NA NA hsa-let-7g-3p SMAD3 -1.14091000722297 8.32736018188759e-19 0.313849246286883 0.00280528337161062 mirMAP -0.100129949934208 0.00883180340844614 NA NA NA hsa-miR-142-5p SMAD3 -1.44575553250033 1.18797044680592e-13 0.313849246286883 0.00280528337161062 PITA -0.125868007472141 6.14850270977044e-07 NA NA NA hsa-miR-155-5p SMAD3 0.0108524225071784 0.95651331033505 0.313849246286883 0.00280528337161062 miRNAWalker2_validate -0.143616291871971 1.61818308217997e-08 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-1976 SMAD3 -0.431472440543166 0.00324575010550946 0.313849246286883 0.00280528337161062 MirTarget -0.177460759581402 2.8140086065009e-07 NA NA NA hsa-miR-29b-2-5p SMAD3 -0.223258653034772 0.084306146519938 0.313849246286883 0.00280528337161062 mirMAP -0.124265788567886 0.00177731205069881 NA NA NA hsa-miR-326 SMAD3 -1.881935132554 1.68087316863775e-21 0.313849246286883 0.00280528337161062 miRanda -0.121886887629074 7.48502793476032e-07 NA NA NA hsa-miR-424-5p SMAD3 -2.62653257498508 2.38997974737991e-50 0.313849246286883 0.00280528337161062 MirTarget -0.105846554796035 3.45471115916176e-05 27655675 miR 424 5p promotes proliferation of gastric cancer by targeting Smad3 through TGF β signaling pathway; QRT-PCR was used to determine the expression levels of miR-424-5p and Smad3; Luciferase reporter assay and western blotting were used to prove that Smad3 was one of the direct targets of miR-424-5p; In addition luciferase reporter assay and western blotting assay revealed that Smad3 was a direct target of miR-424-5p; Over-expression of Smad3 could partially reverse the effects of miR-424-5p on GC cell proliferation; Our study further revealed that miR-424-5p could inhibit TGF-β signaling pathway by Smad3 gastric cancer hsa-miR-29b-2-5p SMAD4 -0.223258653034772 0.084306146519938 -0.30976054630181 7.55983294717014e-05 MirTarget -0.1066651080199 0.000315915680961711 NA NA NA hsa-miR-34a-5p SMAD4 1.03694231790865 5.74864019540594e-14 -0.30976054630181 7.55983294717014e-05 miRNATAP -0.106481148933391 7.14459232465546e-05 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-500a-5p SMAD4 0.797906382969156 9.15958171084226e-08 -0.30976054630181 7.55983294717014e-05 mirMAP -0.104579732494838 3.18281872137464e-05 NA NA NA hsa-miR-17-5p SMAD7 0.698861147045461 2.43854106455398e-05 -0.723856409040082 1.50332971335389e-07 TargetScan;miRNATAP -0.111337794005623 0.00639287149320827 NA NA NA hsa-miR-20a-5p SMAD7 0.854326758727003 5.04256669663285e-07 -0.723856409040082 1.50332971335389e-07 miRNATAP -0.116628969266854 0.00318831344924215 NA NA NA hsa-miR-21-5p SMAD7 1.51084295924322 1.54551622173259e-34 -0.723856409040082 1.50332971335389e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.273576086802476 5.38840691437798e-08 23372687;27185036;26531758 Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MicroRNA 21 Regulates Non Small Cell Lung Cancer Cell Invasion and Chemo Sensitivity through SMAD7; We performed bioinformatics analyses on the binding of microRNA-21 miR-21 to the 3'-UTR of SMAD7 mRNA and verified the biological effects of this binding using promoter luciferase reporter assay; Furthermore expression of miR-21 was found to be inhibited by Carboplatin and bioinformatics analyses showed that miR-21 targeted the 3'-UTR of SMAD7 mRNA to inhibit its translation which was confirmed by luciferase reporter assay; Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFβ receptor signaling mediated NSCLC cell invasion;MicroRNA 21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF β pathways; The present study was undertaken to determine the association of miR-21 smad7 EGF and TGF-β with breast cancer cell invasion and migration and to identify the molecular mechanisms involved using immunohistochemistry and western blot analysis; Smad7 was confirmed to be a direct target of miR-21 by luciferase reporter and western blot assays; The downregulation of smad7 by miR-21 or sismad7 enhanced EGF-dependent invasion and migration as well as TGF-β-dependent invasion and migration; The actions of miR-21 were abrogated by expressing a modified smad7 cDNA resistant to miR-21; In conclusion our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7 which enhances EGF and TGF-β pathways ;; breast cancer;lung squamous cell cancer;breast cancer hsa-miR-34a-5p SMAD7 1.03694231790865 5.74864019540594e-14 -0.723856409040082 1.50332971335389e-07 MirTarget -0.188822980243553 7.67367411949942e-05 NA NA NA hsa-miR-92a-3p SMAD7 0.212391012518195 0.134292268089997 -0.723856409040082 1.50332971335389e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.15091812247193 0.0017147833023436 NA NA NA hsa-miR-93-5p SMAD7 1.39518349670953 2.84167728726712e-25 -0.723856409040082 1.50332971335389e-07 miRNATAP -0.139906211007762 0.00344672878271456 25371073 Mothers against decapentaplegic homolog 7 Smad7 as an essential molecular protein for nuclear accumulation of β-catenin in the canonical Wnt signaling pathway is predicted as a putative target gene of miR-93 by the silico method and demonstrated that it may be suppressed by targeting its 3'UTR; These findings showed that miR-93 suppresses colorectal cancer development via downregulating Wnt/β-catenin at least in part by targeting Smad7 colorectal cancer hsa-miR-148b-3p SNAI2 0.266862251671911 0.00185271302045935 0.384447886331124 0.102927984369101 miRNAWalker2_validate -0.544029940642456 5.49522288288826e-05 NA NA NA hsa-miR-181a-5p SNAI2 0.250113435902954 0.0551933249319293 0.384447886331124 0.102927984369101 miRNAWalker2_validate -0.261350612158367 0.00311299103180595 NA NA NA hsa-miR-182-5p SNAI2 1.96601340710222 4.39326175603633e-09 0.384447886331124 0.102927984369101 miRNAWalker2_validate;miRNATAP -0.103835953273872 0.00197162374541916 NA NA NA hsa-miR-200b-3p SNAI2 -1.29335788099229 0.000268623234305059 0.384447886331124 0.102927984369101 TargetScan -0.113933336744523 0.000370832757095312 NA NA NA hsa-miR-200c-3p SNAI2 -0.104675615392797 0.716957669484981 0.384447886331124 0.102927984369101 miRNATAP -0.13296318092996 0.000812112160068585 NA NA NA hsa-miR-320a SNAI2 0.325285936317332 0.0221415065838824 0.384447886331124 0.102927984369101 miRanda -0.214409102466517 0.00813189487988791 NA NA NA hsa-miR-320b SNAI2 0.0919652022571331 0.607981643616945 0.384447886331124 0.102927984369101 miRanda -0.202087227587785 0.00173449253044878 NA NA NA hsa-miR-330-3p SNAI2 -0.332364259424489 0.0316051913061459 0.384447886331124 0.102927984369101 PITA -0.196504661120588 0.00986696206545639 NA NA NA hsa-miR-335-3p SNAI2 -0.275199247483111 0.106629165248783 0.384447886331124 0.102927984369101 mirMAP -0.217340446715799 0.00125313566599525 NA NA NA hsa-miR-375 SNAI2 -1.93190458972328 4.28108492522e-06 0.384447886331124 0.102927984369101 miRanda -0.209046657886176 1.12811819223104e-15 NA NA NA hsa-miR-429 SNAI2 -1.40262535827285 6.93982219171912e-05 0.384447886331124 0.102927984369101 PITA;miRanda;miRNATAP -0.124379059709461 0.000134132733571897 NA NA NA hsa-miR-126-3p SOX2 -0.652349350198172 9.37876280344772e-09 0.957482238879068 0.017078375832613 miRNAWalker2_validate -0.473141597853484 0.00559309408259033 25585946;25462564;24384842 miR 126 inhibits cell proliferation and induces cell apoptosis of hepatocellular carcinoma cells partially by targeting Sox2; Surprisingly we found that sex-determining region Y-box 2 Sox2 was a putative target gene of miR-126; Thus our data identified miR-126 as a tumor suppressor in HCC through at least partially by targeting Sox2;The expression levels of SOX2 NANOG Oct4 miR-126 and miR-149 were evaluated by quantitative RT-PCR; The mRNA expression levels of SOX2 NANOG and Oct4 were significantly increased in response to the silencing of miR-126 and/or miR-149;miR 126 functions as a tumor suppressor in osteosarcoma by targeting Sox2; Moreover bioinformatic prediction suggested that the sex-determining region Y-box 2 Sox2 is a target gene of miR-126; Taken together our data indicate that miR-126 functions as a tumor suppressor in OS which exerts its activity by suppressing the expression of Sox2 ;drug resistance; liver cancer;prostate cancer;sarcoma hsa-miR-139-5p SOX2 -2.11299531796557 8.16407076415038e-28 0.957482238879068 0.017078375832613 miRanda -0.291129289569908 0.00211494818011014 NA NA NA hsa-miR-28-3p STK3 -0.312894403930205 0.00160942267379584 0.395433514833608 1.88083385820277e-05 MirTarget;PITA -0.171831662910923 0.000174921597629818 NA NA NA hsa-miR-125a-5p TCF7 -0.91219969372382 1.38256246489548e-07 0.316885181039244 0.149291794426295 miRanda -0.219010892235073 0.000315267733055781 NA NA NA hsa-miR-133a-3p TCF7 -0.628141411173506 0.0119847391134837 0.316885181039244 0.149291794426295 MirTarget -0.211821210882707 7.11167273763377e-07 NA NA NA hsa-miR-214-5p TCF7 -1.91497809567701 3.92955595018147e-12 0.316885181039244 0.149291794426295 mirMAP -0.191495267228143 4.22277775127685e-07 NA NA NA hsa-miR-215-5p TCF7 -0.981544773246509 3.14452272477156e-05 0.316885181039244 0.149291794426295 miRNAWalker2_validate;MirTarget -0.173472143860975 0.000107082025354146 NA NA NA hsa-miR-217 TCF7 1.05797297540381 0.0401026692682422 0.316885181039244 0.149291794426295 miRanda -0.130094871894507 1.43494780327072e-10 NA NA NA hsa-miR-24-3p TCF7 -0.257825594021966 0.00689742600215061 0.316885181039244 0.149291794426295 miRNATAP -0.557846852041242 6.44555716594922e-07 NA NA NA hsa-miR-30a-3p TCF7 -1.52720594401486 1.3830066075708e-17 0.316885181039244 0.149291794426295 mirMAP -0.188251012405998 0.00103354405224303 NA NA NA hsa-miR-30e-3p TCF7 -1.20845647373031 3.10263633528203e-25 0.316885181039244 0.149291794426295 mirMAP -0.346228359167188 6.3617494517767e-05 NA NA NA hsa-miR-331-3p TCF7 -0.283974346994635 0.0373785411053202 0.316885181039244 0.149291794426295 MirTarget;miRNATAP -0.479855997763643 5.36153680989195e-10 NA NA NA hsa-miR-628-3p TCF7 -0.958478775877672 6.18965095549213e-08 0.316885181039244 0.149291794426295 PITA -0.225172851464629 0.000189335912104454 NA NA NA hsa-miR-204-5p TCF7L1 -0.537962150012103 0.0330895493358849 -0.133055904354748 0.400767225696702 MirTarget;miRNATAP -0.160817949371994 9.24763373186673e-08 NA NA NA hsa-miR-132-3p TCF7L2 0.323796239695997 0.00272093067935091 -0.337137194899186 7.09586898305443e-05 miRNATAP -0.163055557451342 2.13639390460484e-05 NA NA NA hsa-miR-942-5p TCF7L2 0.346451845105263 0.0283255399972342 -0.337137194899186 7.09586898305443e-05 MirTarget -0.102128789748066 9.53611863162584e-05 NA NA NA hsa-miR-103a-3p TEAD1 0.765568928457606 3.05497476509383e-12 -0.19170590497895 0.104550839525967 mirMAP -0.192567278484453 0.000166223447773516 NA NA NA hsa-miR-140-3p TEAD1 0.546012239205329 4.84578261098777e-11 -0.19170590497895 0.104550839525967 miRNATAP -0.285318549499847 2.90802500673883e-05 NA NA NA hsa-miR-146b-5p TEAD1 0.419719546795449 0.0457375823220155 -0.19170590497895 0.104550839525967 PITA;miRanda -0.149640399760542 2.80064361620845e-08 NA NA NA hsa-miR-151a-3p TEAD1 0.330888909161891 0.00418075524865448 -0.19170590497895 0.104550839525967 mirMAP -0.131789818406995 0.00831347533159573 NA NA NA hsa-miR-16-1-3p TEAD1 0.392360028038559 0.00112481918108198 -0.19170590497895 0.104550839525967 MirTarget;mirMAP -0.175316646351402 0.000230165147670143 NA NA NA hsa-miR-17-5p TEAD1 0.698861147045461 2.43854106455398e-05 -0.19170590497895 0.104550839525967 mirMAP -0.159816549712634 2.87362816486101e-06 NA NA NA hsa-miR-181a-5p TEAD1 0.250113435902954 0.0551933249319293 -0.19170590497895 0.104550839525967 mirMAP;miRNATAP -0.146252843807353 0.000922010692389244 NA NA NA hsa-miR-181b-5p TEAD1 0.488256489401108 0.00105321129419701 -0.19170590497895 0.104550839525967 mirMAP;miRNATAP -0.118713199926625 0.00200784391763121 NA NA NA hsa-miR-185-5p TEAD1 0.480006257154717 6.35758891340152e-07 -0.19170590497895 0.104550839525967 MirTarget;miRNATAP -0.221381541679335 0.0001879781139437 NA NA NA hsa-miR-19b-3p TEAD1 0.601279551368824 0.00016685097085251 -0.19170590497895 0.104550839525967 mirMAP -0.113967014897005 0.00143123944457348 NA NA NA hsa-miR-20a-5p TEAD1 0.854326758727003 5.04256669663285e-07 -0.19170590497895 0.104550839525967 mirMAP -0.128813035539309 0.000106602332750709 NA NA NA hsa-miR-301a-3p TEAD1 0.842910511640361 1.43446467417891e-06 -0.19170590497895 0.104550839525967 mirMAP -0.133308901900571 3.69667576952543e-05 NA NA NA hsa-miR-425-5p TEAD1 0.585974239943864 2.23063410931402e-05 -0.19170590497895 0.104550839525967 mirMAP -0.167059730686998 4.89336648375114e-05 NA NA NA hsa-miR-532-5p TEAD1 1.02729546510601 9.93318913966636e-16 -0.19170590497895 0.104550839525967 PITA;miRNATAP -0.222570653002658 2.27416233536811e-07 NA NA NA hsa-miR-93-5p TEAD1 1.39518349670953 2.84167728726712e-25 -0.19170590497895 0.104550839525967 mirMAP -0.180578704582825 6.60801109149268e-06 NA NA NA hsa-miR-193b-3p TEAD2 -0.166697207281748 0.272022543069482 1.04740203100409 1.09592886614144e-07 miRNAWalker2_validate -0.410305438654245 8.61465591062858e-11 NA NA NA hsa-miR-101-3p TEAD3 -1.48176407980989 3.98950707385704e-31 0.587514117440776 3.53184276495188e-10 miRNATAP -0.183497691208462 4.00252294081543e-08 NA NA NA hsa-miR-107 TEAD4 0.241662461253461 0.0170788899505389 0.630433277502668 0.00388365867682647 miRanda -0.492541846179464 2.94787922490643e-06 NA NA NA hsa-miR-139-5p TGFB1 -2.11299531796557 8.16407076415038e-28 0.0791820105139553 0.6886056388594 miRanda -0.165335310650966 0.000359864512900183 NA NA NA hsa-miR-101-5p TGFB2 -1.0634649894055 4.39116719827902e-16 0.529934214584709 0.036730862150581 mirMAP -0.351880994764185 0.000113322446416492 NA NA NA hsa-miR-107 TGFB2 0.241662461253461 0.0170788899505389 0.529934214584709 0.036730862150581 miRanda -0.614314042069378 4.68765266846655e-07 NA NA NA hsa-miR-148a-3p TGFB2 -0.748702855596996 3.93313343865641e-07 0.529934214584709 0.036730862150581 MirTarget;miRNATAP -0.661431979951743 1.43220896593668e-16 NA NA NA hsa-miR-193a-3p TGFB2 -0.117675551589896 0.309391958208578 0.529934214584709 0.036730862150581 MirTarget;miRanda;miRNATAP -0.366329573810208 0.000659116520736421 NA NA NA hsa-miR-193b-3p TGFB2 -0.166697207281748 0.272022543069482 0.529934214584709 0.036730862150581 MirTarget;miRNATAP -0.318957683478265 9.08737208626492e-05 NA NA NA hsa-miR-33a-3p TGFB2 -0.683025859637737 1.01106097756419e-05 0.529934214584709 0.036730862150581 MirTarget;mirMAP -0.292910263006269 0.00021856118592367 NA NA NA hsa-miR-362-3p TGFB2 0.814007335895913 2.00108618836568e-09 0.529934214584709 0.036730862150581 miRanda -0.235702914624554 0.00870288726391307 NA NA NA hsa-miR-548b-3p TGFB2 -0.0203576084717134 0.930819503166956 0.529934214584709 0.036730862150581 MirTarget -0.251413034966269 2.19240613879876e-06 NA NA NA hsa-miR-616-5p TGFB2 0.150569904638223 0.402836556304524 0.529934214584709 0.036730862150581 mirMAP -0.373291858655729 4.43049125036333e-08 NA NA NA hsa-miR-618 TGFB2 0.13539895350352 0.517145913114103 0.529934214584709 0.036730862150581 MirTarget;miRNATAP -0.323812991792447 9.41184108923406e-08 NA NA NA hsa-miR-151a-5p TGFB3 0.484893436232714 4.8995594459361e-06 -0.549558180002636 0.00349778458392359 MirTarget -0.493845417648935 6.80157351019684e-09 NA NA NA hsa-miR-106b-5p TGFBR2 0.648901865047099 8.24870862047885e-09 -0.522706741081292 3.47206054315007e-05 miRNATAP -0.368277930860382 4.29748674542316e-12 NA NA NA hsa-miR-130b-3p TGFBR2 0.687190305027546 0.000109068658562255 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.131252693120461 0.000144540113312326 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 0.698861147045461 2.43854106455398e-05 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.203186001893041 2.94531720390227e-08 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-18a-5p TGFBR2 0.918028187958706 1.90229510425322e-05 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate -0.192780882131928 5.02272007870357e-12 NA NA NA hsa-miR-19a-3p TGFBR2 1.01712596153672 2.57753201450625e-07 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.149425406079401 1.09582904607366e-06 NA NA NA hsa-miR-19b-3p TGFBR2 0.601279551368824 0.00016685097085251 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.16137896859351 2.62064707293945e-05 NA NA NA hsa-miR-20a-5p TGFBR2 0.854326758727003 5.04256669663285e-07 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.177394018081005 6.48951647363697e-07 NA NA NA hsa-miR-21-5p TGFBR2 1.51084295924322 1.54551622173259e-34 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.236840105633096 2.41705180023436e-07 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-301a-3p TGFBR2 0.842910511640361 1.43446467417891e-06 -0.522706741081292 3.47206054315007e-05 miRNATAP -0.183722985598573 1.11942744399345e-07 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-501-3p TGFBR2 0.999540908940094 2.77358485581974e-11 -0.522706741081292 3.47206054315007e-05 TargetScan -0.116887889145825 0.0037841236086272 NA NA NA hsa-miR-590-5p TGFBR2 -0.103355559980404 0.310027295317092 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.253149374960949 3.5308611333711e-05 NA NA NA hsa-miR-92a-3p TGFBR2 0.212391012518195 0.134292268089997 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate -0.17351362748106 7.02401539230513e-05 NA NA NA hsa-miR-93-5p TGFBR2 1.39518349670953 2.84167728726712e-25 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.263677361634044 7.09611188180981e-10 NA NA NA hsa-miR-22-5p TP53BP2 -0.630365901263172 3.32415348030414e-05 0.506787628360036 6.38032005929187e-05 miRNATAP -0.130149983584552 0.00135630180058076 NA NA NA hsa-miR-10a-5p TP73 -1.47723516092033 7.27299669108673e-16 3.12737351940272 1.41162077669157e-23 mirMAP -0.650895757730988 2.49244233467107e-15 NA NA NA hsa-miR-127-5p TP73 -1.30084454872193 2.78105401208939e-07 3.12737351940272 1.41162077669157e-23 mirMAP -0.292062239826154 2.67364792194748e-06 NA NA NA hsa-miR-142-3p TP73 -1.4243101967815 1.92609481097765e-14 3.12737351940272 1.41162077669157e-23 miRanda -0.325422155570923 9.85928391154188e-05 NA NA NA hsa-miR-200b-3p TP73 -1.29335788099229 0.000268623234305059 3.12737351940272 1.41162077669157e-23 MirTarget;TargetScan -0.126731670549702 0.0049129791909471 23389960 Down regulation of miR 200b 3p by low p73 contributes to the androgen independence of prostate cancer cells; In this study we investigated the role that the interaction between miR-200b-3p and p73 plays in the proliferation of AIPC; Then we examined the effect of p73 and miR-200b-3p on the proliferation of AIPC and ADPC using CCK-8; Furthermore we investigated the regulation of miR-200b-3p by p73 prostate cancer hsa-miR-22-3p TP73 -0.628561621952407 1.33755558015523e-09 3.12737351940272 1.41162077669157e-23 mirMAP -0.808179945720649 1.06012353664804e-07 NA NA NA hsa-miR-24-3p TP73 -0.257825594021966 0.00689742600215061 3.12737351940272 1.41162077669157e-23 mirMAP -0.493125920104719 0.00383085887965063 NA NA NA hsa-miR-335-5p TP73 -1.61347836513558 1.62757083289711e-19 3.12737351940272 1.41162077669157e-23 mirMAP -0.494753534862885 5.84122531985338e-09 NA NA NA hsa-miR-429 TP73 -1.40262535827285 6.93982219171912e-05 3.12737351940272 1.41162077669157e-23 MirTarget;miRNATAP -0.161758102148855 0.000410585182804045 NA NA NA hsa-miR-542-3p TP73 -1.31351015149842 3.64642423288576e-22 3.12737351940272 1.41162077669157e-23 mirMAP -0.917477829359528 3.84907764521149e-17 NA NA NA hsa-miR-378a-3p WNT10A -1.1920055906972 3.23538871733634e-10 -0.699775326592301 0.014837769527789 MirTarget;miRNATAP -0.311876203963016 1.46588032688135e-05 NA NA NA hsa-miR-378c WNT10A -1.54028191929038 2.70131554214866e-15 -0.699775326592301 0.014837769527789 MirTarget;miRNATAP -0.223225797245087 0.00130113406406967 NA NA NA hsa-miR-664a-3p WNT10A 0.485807855553031 0.000732553249798598 -0.699775326592301 0.014837769527789 mirMAP -0.334039889137342 0.000582315884836279 NA NA NA hsa-miR-362-3p WNT2 0.814007335895913 2.00108618836568e-09 -3.91913726472358 3.44531322240171e-22 miRanda -0.596906309855373 7.09333385741009e-05 NA NA NA hsa-miR-532-5p WNT2 1.02729546510601 9.93318913966636e-16 -3.91913726472358 3.44531322240171e-22 miRNATAP -1.17021689287712 1.95625819314329e-14 NA NA NA hsa-miR-548b-3p WNT2 -0.0203576084717134 0.930819503166956 -3.91913726472358 3.44531322240171e-22 MirTarget -0.502061495825289 1.54565101391317e-08 NA NA NA hsa-miR-32-3p WNT2B 0.219109440121582 0.207217051619543 0.919797388731247 8.84184321894967e-05 mirMAP -0.226091442559667 0.000967084434027044 NA NA NA hsa-miR-616-5p WNT2B 0.150569904638223 0.402836556304524 0.919797388731247 8.84184321894967e-05 mirMAP -0.357146678596839 1.78631568677685e-08 NA NA NA hsa-miR-1301-3p WNT3 1.12156714169769 4.22404125385203e-10 -0.0427691985857284 0.782956133291661 miRNAWalker2_validate -0.111768467724203 0.00665968425980419 NA NA NA hsa-miR-146a-5p WNT3 -0.742958238440575 0.000765983177482633 -0.0427691985857284 0.782956133291661 MirTarget -0.113145320629351 0.000853907137316349 NA NA NA hsa-miR-324-3p WNT3 0.260348469146494 0.0506141704203545 -0.0427691985857284 0.782956133291661 MirTarget -0.152449309964257 0.0073953316853805 NA NA NA hsa-miR-195-5p WNT3A -1.85907534356434 1.47434041676402e-22 1.98708616870099 1.63071643507271e-06 MirTarget;miRNATAP -0.344445023915739 0.000703711150128669 25174704;26573286 MicroRNA 195 acts as a tumor suppressor by directly targeting Wnt3a in HepG2 hepatocellular carcinoma cells; Luciferase reporter assay was used to determine whether Wnt3a was a target of miR-195; Furthermore Wnt3a was demonstrated to be directly targeted by miR-195; These findings suggest that miR-195 is key in regulating cell proliferation cell cycle and apoptosis through targeting Wnt3a;Eribulin upregulates miR 195 expression and downregulates Wnt3a expression in non basal like type of triple negative breast cancer cell MDA MB 231; The expression level of miR-195 targeting Wnt3a significantly decreased compared to the control in MDA-MB-231 whereas it significantly increased in HCC1143; These results showed that exposure to eribulin highly increased the expression of miR-195 while it decreased the expression of Wnt3a in non-basal-like type of TNBC ; liver cancer;breast cancer hsa-miR-27b-3p WNT3A -0.823491817819754 9.20935302746823e-14 1.98708616870099 1.63071643507271e-06 miRNATAP -0.548421477531898 0.00239496180403094 NA NA NA hsa-miR-335-5p WNT3A -1.61347836513558 1.62757083289711e-19 1.98708616870099 1.63071643507271e-06 mirMAP -0.466783584252119 1.77594430006242e-05 NA NA NA hsa-miR-424-5p WNT3A -2.62653257498508 2.38997974737991e-50 1.98708616870099 1.63071643507271e-06 MirTarget;miRNATAP -0.276402093402075 0.00707893809064417 NA NA NA hsa-miR-107 WNT4 0.241662461253461 0.0170788899505389 -0.395843982979098 0.363792495355894 PITA;miRNATAP -1.20015521254906 8.09058681955679e-09 NA NA NA hsa-miR-375 WNT5A -1.93190458972328 4.28108492522e-06 -0.379867591757487 0.265970692489084 miRNATAP -0.114882013104506 0.00325292733019044 NA NA NA hsa-miR-185-5p WNT5B 0.480006257154717 6.35758891340152e-07 -1.13697207573161 0.000217274755514595 miRNAWalker2_validate -0.637058578135861 4.15131637965874e-05 NA NA NA hsa-miR-10b-5p WNT7B 2.86931593037303 6.97409423207806e-23 -2.49986156980565 3.55477150766295e-09 mirMAP -0.274981207829556 5.13137898629338e-05 NA NA NA hsa-miR-34a-5p WNT7B 1.03694231790865 5.74864019540594e-14 -2.49986156980565 3.55477150766295e-09 mirMAP -0.871435014929295 2.29802092991709e-09 NA NA NA hsa-miR-505-3p WNT7B -1.20027021591555 1.27927500175937e-13 -2.49986156980565 3.55477150766295e-09 miRNATAP -0.343304152336908 0.00653008300029439 NA NA NA hsa-miR-107 WTIP 0.241662461253461 0.0170788899505389 -0.0832426426141142 0.690200115614904 mirMAP -0.412833936041321 4.05964914288175e-05 NA NA NA hsa-miR-140-3p WTIP 0.546012239205329 4.84578261098777e-11 -0.0832426426141142 0.690200115614904 mirMAP -0.34445527141352 0.00455183340985967 NA NA NA hsa-miR-15a-5p WTIP 0.349521211668244 0.000770735998804736 -0.0832426426141142 0.690200115614904 mirMAP -0.29463639461455 0.00267774255027973 NA NA NA hsa-miR-15b-5p WTIP 0.230566941413564 0.0824765001857479 -0.0832426426141142 0.690200115614904 mirMAP -0.230475554756268 0.00269502329077364 NA NA NA hsa-miR-186-5p WTIP -0.060103391373687 0.535288717081205 -0.0832426426141142 0.690200115614904 mirMAP -0.457756108136017 1.4272095059121e-05 NA NA NA hsa-miR-192-3p WTIP -0.6401165114007 0.000266272092403814 -0.0832426426141142 0.690200115614904 mirMAP -0.518330466923842 3.62497039745491e-21 NA NA NA hsa-miR-193a-5p WTIP -0.472805720224262 1.24962968905481e-05 -0.0832426426141142 0.690200115614904 mirMAP -0.304114554403808 0.00115969072776148 NA NA NA hsa-miR-193b-3p WTIP -0.166697207281748 0.272022543069482 -0.0832426426141142 0.690200115614904 mirMAP -0.415965506162981 2.81066085181675e-10 NA NA NA hsa-miR-193b-5p WTIP -0.748481053559202 3.37008423124215e-06 -0.0832426426141142 0.690200115614904 mirMAP -0.425888419264389 2.93167491484993e-12 NA NA NA hsa-miR-194-5p WTIP -0.292530160992458 0.0996141384876663 -0.0832426426141142 0.690200115614904 mirMAP -0.518590841195274 1.9596398848406e-21 NA NA NA hsa-miR-197-3p WTIP -0.245033899783728 0.0362223947695203 -0.0832426426141142 0.690200115614904 mirMAP -0.275125390235428 0.00161465871749674 NA NA NA hsa-miR-224-3p WTIP 1.40770116795301 1.31426607144612e-08 -0.0832426426141142 0.690200115614904 mirMAP -0.136303154673275 0.000818990852537711 NA NA NA hsa-miR-33b-5p WTIP -2.28852395459234 2.69046626645242e-22 -0.0832426426141142 0.690200115614904 mirMAP -0.121400183554476 0.00315510751876842 NA NA NA hsa-miR-34a-5p WTIP 1.03694231790865 5.74864019540594e-14 -0.0832426426141142 0.690200115614904 mirMAP -0.201436728429057 0.00489904366312482 NA NA NA hsa-miR-365a-3p WTIP 0.164591326307714 0.15325084963213 -0.0832426426141142 0.690200115614904 mirMAP -0.454088077418904 2.34975584295579e-07 NA NA NA hsa-miR-455-3p WTIP -1.3998033821095 5.72010709806871e-17 -0.0832426426141142 0.690200115614904 mirMAP -0.175801256772203 0.00263244869579529 NA NA NA hsa-miR-550a-5p WTIP 0.156224023171823 0.282505553619229 -0.0832426426141142 0.690200115614904 mirMAP -0.240285689418691 0.00061168701047687 NA NA NA hsa-miR-589-5p WTIP 1.18593770505086 1.01781241960531e-22 -0.0832426426141142 0.690200115614904 mirMAP -0.261564833553027 0.00105905252430326 NA NA NA hsa-miR-15a-5p WWC1 0.349521211668244 0.000770735998804736 -0.0161026660407861 0.921171669363241 MirTarget;miRNATAP -0.375295222921777 7.14197465337921e-07 NA NA NA hsa-miR-20a-5p WWC1 0.854326758727003 5.04256669663285e-07 -0.0161026660407861 0.921171669363241 mirMAP -0.128497978139045 0.00519897748400934 NA NA NA hsa-miR-20b-5p WWC1 0.457668023910379 0.0285865211936156 -0.0161026660407861 0.921171669363241 mirMAP -0.109817069384545 0.00365195437422561 NA NA NA hsa-miR-32-5p WWC1 0.0806126674664016 0.548984992497432 -0.0161026660407861 0.921171669363241 miRNATAP -0.292838618802179 5.70579812845976e-07 NA NA NA hsa-miR-130b-5p WWTR1 0.170599813152408 0.337611586432771 -0.430971920019913 0.016793119742098 MirTarget;miRNATAP -0.21031581182616 1.94208352926465e-05 NA NA NA hsa-miR-17-3p WWTR1 0.410352776142368 0.00422200500748636 -0.430971920019913 0.016793119742098 MirTarget -0.374639628361785 4.93205986633625e-10 NA NA NA hsa-miR-18a-5p WWTR1 0.918028187958706 1.90229510425322e-05 -0.430971920019913 0.016793119742098 miRNAWalker2_validate -0.22939558601327 9.58120825273775e-09 NA NA NA hsa-miR-193a-3p WWTR1 -0.117675551589896 0.309391958208578 -0.430971920019913 0.016793119742098 miRanda -0.25209765396762 0.000976188888984469 NA NA NA hsa-miR-501-5p WWTR1 1.15231083477882 2.98906150004088e-10 -0.430971920019913 0.016793119742098 mirMAP -0.165039145048347 0.000447595201173187 NA NA NA hsa-miR-93-3p WWTR1 0.402821129107592 0.00131324842735588 -0.430971920019913 0.016793119742098 MirTarget -0.183073368213084 0.00917815677234016 NA NA NA hsa-miR-361-3p YAP1 0.275658012727111 0.00549374744374488 -0.133113769806243 0.234234947221133 MirTarget;PITA -0.191382264822593 0.000508428194531186 NA NA NA hsa-miR-484 YAP1 0.0857240033709656 0.453982056282229 -0.133113769806243 0.234234947221133 PITA;miRNATAP -0.182156699654888 0.000134573315505628 NA NA NA hsa-miR-590-5p YAP1 -0.103355559980404 0.310027295317092 -0.133113769806243 0.234234947221133 MirTarget;PITA;miRanda;miRNATAP -0.159748709988294 0.00307860131904935 NA NA NA hsa-miR-616-5p YAP1 0.150569904638223 0.402836556304524 -0.133113769806243 0.234234947221133 mirMAP -0.101316676456443 0.000825356697839245 NA NA NA hsa-miR-107 YWHAB 0.241662461253461 0.0170788899505389 0.173432047741129 0.000884243127746855 miRanda -0.108037306925883 1.47087762859095e-05 NA NA NA hsa-miR-148a-3p YWHAB -0.748702855596996 3.93313343865641e-07 0.173432047741129 0.000884243127746855 MirTarget;miRNATAP -0.132820922282045 4.13292521804208e-16 NA NA NA hsa-miR-186-5p YWHAE -0.060103391373687 0.535288717081205 -0.389050776848833 1.87949073175552e-07 miRNAWalker2_validate -0.127528287333916 0.000863275542227347 NA NA NA hsa-miR-192-3p YWHAH -0.6401165114007 0.000266272092403814 0.381424797266773 9.9564983661589e-07 MirTarget -0.123473061996178 7.45881423647248e-09 NA NA NA hsa-miR-139-5p YWHAQ -2.11299531796557 8.16407076415038e-28 0.105106147496931 0.185320360738181 MirTarget;PITA;miRanda;miRNATAP -0.134903753655919 8.26465948813414e-14 NA NA NA hsa-miR-140-5p YWHAQ -0.220106443070144 0.0140713197101242 0.105106147496931 0.185320360738181 miRanda -0.114458361490446 0.00840912415391188 NA NA NA hsa-miR-328-3p YWHAQ -0.547466865311955 6.8359574451572e-06 0.105106147496931 0.185320360738181 miRNAWalker2_validate -0.117573761953222 0.000175415891769642 NA NA NA hsa-miR-497-5p YWHAQ -1.41371173021948 7.09278946477743e-17 0.105106147496931 0.185320360738181 MirTarget;miRNATAP -0.10611692853337 9.41242986957199e-07 NA NA NA hsa-miR-193b-3p YWHAZ -0.166697207281748 0.272022543069482 0.521348507448096 2.46588555709085e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.215846083623554 1.05246240233955e-09 NA NA NA hsa-miR-195-3p YWHAZ -1.09375690196245 4.70092324819807e-09 0.521348507448096 2.46588555709085e-06 MirTarget -0.123410355780779 1.86763692080896e-05 NA NA NA hsa-miR-22-3p YWHAZ -0.628561621952407 1.33755558015523e-09 0.521348507448096 2.46588555709085e-06 MirTarget -0.422402725731077 3.08582185459414e-17 NA NA NA hsa-miR-28-5p YWHAZ -0.430964830599964 2.67367257252925e-06 0.521348507448096 2.46588555709085e-06 PITA;miRanda;miRNATAP -0.378439288562354 7.80189740644095e-11 NA NA NA hsa-miR-30a-5p YWHAZ -0.626257932887855 0.000108198196973765 0.521348507448096 2.46588555709085e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.137637850164864 3.55605716079781e-05 NA NA NA hsa-miR-30c-5p YWHAZ -0.432111642767632 0.000159764714931007 0.521348507448096 2.46588555709085e-06 MirTarget;miRNATAP -0.217149970191143 4.21662119138978e-06 24519092 Involvement of miR 30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells; Together our findings provided evidence that miR-30c was one of the important miRNAs in doxorubicin resistance by regulating YWHAZ in the breast cancer cell line MCF-7/ADR drug resistance breast cancer hsa-miR-30e-5p YWHAZ -0.627815042856657 3.02205690184908e-10 0.521348507448096 2.46588555709085e-06 MirTarget;miRNATAP -0.512830738492514 1.08747499679871e-23 NA NA NA hsa-miR-328-3p YWHAZ -0.547466865311955 6.8359574451572e-06 0.521348507448096 2.46588555709085e-06 MirTarget -0.184846832867037 2.98681633637662e-05 NA NA NA hsa-miR-340-3p YWHAZ -0.329393899588902 0.00329627776838916 0.521348507448096 2.46588555709085e-06 miRNAWalker2_validate -0.145643740083093 0.00280561227887093 NA NA NA hsa-miR-374a-3p YWHAZ -0.207171354826929 0.0623494608399903 0.521348507448096 2.46588555709085e-06 mirMAP -0.243786914759101 6.00089907045834e-07 NA NA NA hsa-miR-378a-3p YWHAZ -1.1920055906972 3.23538871733634e-10 0.521348507448096 2.46588555709085e-06 miRNAWalker2_validate -0.229761242047093 2.06324870493417e-17 NA NA NA hsa-miR-451a YWHAZ -2.1025161666445 6.82555767537341e-17 0.521348507448096 2.46588555709085e-06 MirTarget;miRNATAP -0.125160799099819 8.46499537092129e-10 26885274 miR 451 regulates FoxO3 nuclear accumulation through Ywhaz in human colorectal cancer; In this study expressions of miR-451 and Ywhaz in CRC tissues and adjacent normal tissues were detected by quantitative real-time PCR qRT-PCR and immunohistochemistry respectively; Ywhaz-3'UTR luciferase reporter assay confirmed Ywhaz as a direct target gene of miR-451; miR-451 may inhibit the colon cancer growth in vitro and in vivo likely through directly targeting Ywhaz and indirectly regulating the nuclear accumulation of FoxO3 colorectal cancer hsa-miR-455-3p YWHAZ -1.3998033821095 5.72010709806871e-17 0.521348507448096 2.46588555709085e-06 miRNAWalker2_validate -0.163253715474292 1.350262159478e-07 NA NA NA hsa-miR-505-5p YWHAZ -0.768282569967001 1.14662846595407e-05 0.521348507448096 2.46588555709085e-06 MirTarget;miRNATAP -0.138532797418727 5.93157816903527e-06 NA NA NA hsa-miR-576-5p YWHAZ -0.377452008285847 0.00470735657343984 0.521348507448096 2.46588555709085e-06 mirMAP -0.244889551272521 1.02393670706879e-09 NA NA NA hsa-miR-664a-3p YWHAZ 0.485807855553031 0.000732553249798598 0.521348507448096 2.46588555709085e-06 mirMAP -0.120325216996267 0.00142367135354135 NA NA NA hsa-miR-7-1-3p YWHAZ -0.569105143287799 1.85297665041424e-05 0.521348507448096 2.46588555709085e-06 mirMAP -0.154608457268063 0.000140054345497285 NA NA NA