miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-200c-3p ACTC1 3.50132673580082 2.42716349086937e-15 -7.18598491180022 4.5953181070502e-12 MirTarget -1.33961147875603 5.78382641132517e-39 NA NA NA hsa-miR-200c-3p ADAMTS3 3.50132673580082 2.42716349086937e-15 -1.18158075880111 0.00447810281876853 miRNATAP -0.412864046827974 4.8774551323927e-23 NA NA NA hsa-miR-200c-3p ADCY2 3.50132673580082 2.42716349086937e-15 -3.86571368883929 3.85227988382588e-11 MirTarget;miRNATAP -0.439764377269818 9.87649048383691e-13 NA NA NA hsa-miR-200c-3p AFF3 3.50132673580082 2.42716349086937e-15 -5.00307584182747 3.17401839817713e-23 MirTarget;miRNATAP -0.594392924880098 8.99521592502589e-30 NA NA NA hsa-miR-200c-3p AP1S2 3.50132673580082 2.42716349086937e-15 -1.3126608153732 9.8644272412276e-09 MirTarget;miRNATAP -0.377382973437296 3.78470396738381e-76 NA NA NA hsa-miR-200c-3p ARHGAP20 3.50132673580082 2.42716349086937e-15 -3.51958526332557 1.95510990509183e-16 MirTarget;miRNATAP -0.506742392754481 2.98862963888212e-31 NA NA NA hsa-miR-200c-5p ATP1A2 2.95761105443819 3.11105707262802e-11 -6.96102449322155 1.04173487274373e-23 MirTarget -0.880443870815857 3.72878871461367e-30 NA NA NA hsa-miR-200c-3p BACH2 3.50132673580082 2.42716349086937e-15 -1.52271748612635 0.00133867288726185 mirMAP -0.543118577995022 3.61874329395113e-31 NA NA NA hsa-miR-200c-3p BEND4 3.50132673580082 2.42716349086937e-15 -1.96898871811517 7.28857253483474e-05 mirMAP -0.318293614323673 8.49110039241365e-10 NA NA NA hsa-miR-200c-3p BNC2 3.50132673580082 2.42716349086937e-15 -2.95176911794991 3.46014802400024e-09 MirTarget -0.700058514263773 1.38610836642505e-48 NA NA NA hsa-miR-200c-3p C11orf87 3.50132673580082 2.42716349086937e-15 -1.54750698600423 0.0118571289052622 miRNATAP -0.339559370670116 1.28086252300675e-07 NA NA NA hsa-miR-200c-3p CACNA1C 3.50132673580082 2.42716349086937e-15 -2.53203105122136 8.2041496030931e-11 MirTarget -0.436093474539072 1.71924843611962e-28 NA NA NA hsa-miR-200c-5p CACNB2 2.95761105443819 3.11105707262802e-11 -2.97276927954599 1.73108973462894e-15 MirTarget;miRNATAP -0.347526072189 1.59573625844042e-16 NA NA NA hsa-miR-200c-5p CASQ2 2.95761105443819 3.11105707262802e-11 -6.22316803933265 3.19514147554355e-14 MirTarget -1.10554480494884 1.53651583069118e-36 NA NA NA hsa-miR-200c-5p CCDC141 2.95761105443819 3.11105707262802e-11 -2.93849988362368 3.4694116937076e-12 MirTarget -0.435640642943703 1.13031852435868e-20 NA NA NA hsa-miR-200c-3p CDK6 3.50132673580082 2.42716349086937e-15 -0.774202349805119 0.064787030605636 mirMAP -0.320385878451071 9.82419842455136e-14 NA NA NA hsa-miR-200c-3p CELF2 3.50132673580082 2.42716349086937e-15 -3.04719737979328 4.72041352009215e-15 mirMAP;miRNATAP -0.507522314324143 2.26364434641141e-39 NA NA NA hsa-miR-200c-5p CELF2 2.95761105443819 3.11105707262802e-11 -3.04719737979328 4.72041352009215e-15 miRNATAP -0.53322239394209 8.0605859416795e-38 NA NA NA hsa-miR-200c-3p CFL2 3.50132673580082 2.42716349086937e-15 -2.61712932503392 6.6876672984936e-21 MirTarget;miRNATAP -0.47775192139898 1.87065344817105e-77 23497265 We characterized one of the target genes of miR-200c CFL2 and demonstrated that CFL2 is overexpressed in aggressive breast cancer cell lines and can be significantly down-regulated by exogenous miR-200c breast cancer hsa-miR-200c-3p CHRDL1 3.50132673580082 2.42716349086937e-15 -6.14628787036669 1.26356425887682e-13 MirTarget -0.98650234374657 4.70579040070454e-32 NA NA NA hsa-miR-200c-3p CHST11 3.50132673580082 2.42716349086937e-15 0.53998313547079 0.231103989518921 mirMAP -0.40264937459085 1.14560011127373e-18 NA NA NA hsa-miR-200c-3p CLIC4 3.50132673580082 2.42716349086937e-15 -1.72389310060141 6.21382968572505e-08 MirTarget;miRNATAP -0.456334265563461 6.59418212524645e-52 NA NA NA hsa-miR-200c-3p CNTFR 3.50132673580082 2.42716349086937e-15 -3.85610534555259 4.26251450212736e-08 miRNATAP -0.437014825669292 4.0789929368456e-09 NA NA NA hsa-miR-200c-3p CNTN1 3.50132673580082 2.42716349086937e-15 -4.98280431564283 1.02293078354206e-09 MirTarget;miRNATAP -0.740154385698551 1.87627897077188e-18 NA NA NA hsa-miR-200c-5p COL11A1 2.95761105443819 3.11105707262802e-11 4.68886927590747 2.15659824797734e-08 MirTarget;miRNATAP -0.57292334566073 1.32296460501734e-09 NA NA NA hsa-miR-200c-3p COL4A3 3.50132673580082 2.42716349086937e-15 -3.13816823718198 5.72507717181151e-07 miRNATAP -0.321328173209356 1.3577907991277e-06 NA NA NA hsa-miR-200c-3p CREB5 3.50132673580082 2.42716349086937e-15 -2.27679484644664 4.56595042875634e-09 miRNATAP -0.470215746107068 2.55597087862817e-34 NA NA NA hsa-miR-200c-3p CYP1B1 3.50132673580082 2.42716349086937e-15 -2.81828860701069 1.61767262798723e-06 miRNATAP -0.551390909310453 4.13814066664356e-20 25860934 Loss of miR 200c up regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma; Additionally miR-200c which is significantly down-regulated in RCC regulates CYP1B1 expression and activity; An inverse association was also observed between the expression levels of miR-200c and CYP1B1 protein in RCC tissues; Restoration of docetaxel resistance by exogenous expression of CYP1B1 in miR-200c-over-expressing cells indicates that CYP1B1 is a functional target of miR-200c; These results suggest that CYP1B1 up-regulation mediated by low miR-200c is one of the mechanisms underlying resistance of RCC cells to docetaxel; Therefore expression of CYP1B1 and miR-200c in RCC may be useful as a prediction for docetaxel response drug resistance kidney renal cell cancer hsa-miR-200c-3p DACT1 3.50132673580082 2.42716349086937e-15 -1.78085143314576 2.05886005067419e-05 miRNATAP -0.468544911780467 1.83843895910496e-29 NA NA NA hsa-miR-200c-3p DCBLD2 3.50132673580082 2.42716349086937e-15 -0.127512036942836 0.735967995495379 MirTarget -0.310752657713804 7.31627359199509e-16 NA NA NA hsa-miR-200c-3p DDIT4L 3.50132673580082 2.42716349086937e-15 -1.9019553090965 0.000465737260753943 MirTarget -0.467650323407764 4.09937437157122e-17 NA NA NA hsa-miR-200c-3p DENND5B 3.50132673580082 2.42716349086937e-15 -1.35091655519941 9.63273930805463e-05 MirTarget;miRNATAP -0.388782737688361 1.06463025647737e-29 NA NA NA hsa-miR-200c-3p DIXDC1 3.50132673580082 2.42716349086937e-15 -3.01066558370526 1.36952954348107e-19 MirTarget -0.51565835630041 5.52676022504697e-59 NA NA NA hsa-miR-200c-3p DMD 3.50132673580082 2.42716349086937e-15 -3.69368719337714 3.87883942927561e-15 miRNATAP -0.530227342483484 2.76303130186155e-28 NA NA NA hsa-miR-200c-3p DNAJB5 3.50132673580082 2.42716349086937e-15 -2.65207059462743 2.68507855515511e-15 miRNATAP -0.523417573865588 8.66882403219181e-62 NA NA NA hsa-miR-200c-3p DRP2 3.50132673580082 2.42716349086937e-15 -1.34779224755633 0.000228883511200255 mirMAP -0.3120874276009 8.16166065202024e-17 NA NA NA hsa-miR-200c-3p DTNA 3.50132673580082 2.42716349086937e-15 -4.06049121456747 1.59577306327407e-12 MirTarget -0.646651183559355 1.51981975883497e-28 NA NA NA hsa-miR-200c-5p DTNA 2.95761105443819 3.11105707262802e-11 -4.06049121456747 1.59577306327407e-12 MirTarget;miRNATAP -0.662707328761072 4.60200744803365e-26 NA NA NA hsa-miR-200c-3p DUSP1 3.50132673580082 2.42716349086937e-15 -3.47418646928724 1.98436002754553e-20 MirTarget;miRNATAP -0.31571143226552 4.3503827266648e-15 NA NA NA hsa-miR-200c-3p DZIP1 3.50132673580082 2.42716349086937e-15 -1.57008196403815 1.8435672027566e-05 MirTarget -0.337163109371172 1.97667084535266e-19 NA NA NA hsa-miR-200c-3p EDNRA 3.50132673580082 2.42716349086937e-15 -2.18719306101688 8.33789654397051e-10 miRNAWalker2_validate;miRNATAP -0.429900561340471 6.58562337198449e-34 NA NA NA hsa-miR-200c-5p EML1 2.95761105443819 3.11105707262802e-11 -2.07414124578219 2.91917682720807e-09 MirTarget -0.326907997601138 2.96943718407368e-17 NA NA NA hsa-miR-200c-3p F2RL2 3.50132673580082 2.42716349086937e-15 -0.074170778593706 0.882857232515843 MirTarget -0.402243298496942 5.13495429583168e-15 NA NA NA hsa-miR-200c-5p FAM110B 2.95761105443819 3.11105707262802e-11 -2.48922603317359 1.34073850217782e-09 MirTarget -0.519769580868833 1.51274145310849e-32 NA NA NA hsa-miR-200c-3p FBLN5 3.50132673580082 2.42716349086937e-15 -2.7572810002915 1.11240697718667e-13 miRNAWalker2_validate;miRTarBase -0.400109932439159 7.56529266726843e-26 NA NA NA hsa-miR-200c-3p FGF2 3.50132673580082 2.42716349086937e-15 -3.45935256477983 3.20406041037898e-17 mirMAP -0.581898672989235 1.2281612826909e-47 NA NA NA hsa-miR-200c-3p FHL1 3.50132673580082 2.42716349086937e-15 -4.79489740738213 4.58621609455402e-20 MirTarget -0.777950964097711 1.07858115739551e-52 NA NA NA hsa-miR-200c-3p FLI1 3.50132673580082 2.42716349086937e-15 -1.10881984531465 6.56713737767845e-05 MirTarget;miRNATAP -0.315112566669429 2.08862569284463e-30 NA NA NA hsa-miR-200c-3p FLNA 3.50132673580082 2.42716349086937e-15 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.573278326556171 6.53243471319789e-65 NA NA NA hsa-miR-200c-3p FN1 3.50132673580082 2.42716349086937e-15 -0.407678263046535 0.457934813442308 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.661896693895972 1.64136219365611e-35 NA NA NA hsa-miR-200c-3p FOXF1 3.50132673580082 2.42716349086937e-15 -3.59969497191247 8.05975763421163e-22 MirTarget -0.332527775439702 1.38577657244357e-16 NA NA NA hsa-miR-200c-3p FSTL1 3.50132673580082 2.42716349086937e-15 -1.20409366079041 3.08470468877507e-05 MirTarget -0.363468259803467 2.09035802399296e-38 NA NA NA hsa-miR-200c-3p FYN 3.50132673580082 2.42716349086937e-15 -1.46508592139092 9.74677213788621e-08 miRNATAP -0.35092340815277 3.35510281801253e-39 NA NA NA hsa-miR-200c-3p GEM 3.50132673580082 2.42716349086937e-15 -3.69134770515528 5.61525969896728e-16 MirTarget;miRNATAP -0.59591901710192 2.64134984555771e-39 NA NA NA hsa-miR-200c-3p GFRA1 3.50132673580082 2.42716349086937e-15 -4.99535302188274 6.14065741522982e-16 mirMAP -0.326378196591011 1.11002175660837e-06 NA NA NA hsa-miR-200c-3p GJC1 3.50132673580082 2.42716349086937e-15 -0.972020676723743 0.00222017431601357 MirTarget;miRNATAP -0.312348068065492 1.57157651177237e-22 NA NA NA hsa-miR-200c-3p GLIS2 3.50132673580082 2.42716349086937e-15 -0.610818722003668 0.0527901481345749 miRNATAP -0.314830299269461 1.99437681270576e-23 NA NA NA hsa-miR-200c-5p GNAO1 2.95761105443819 3.11105707262802e-11 -3.60402838064813 1.60858876204295e-14 MirTarget -0.621236863643885 5.74495615264764e-35 NA NA NA hsa-miR-200c-3p GNG4 3.50132673580082 2.42716349086937e-15 0.216159437363437 0.744682539041036 mirMAP -0.415747931208297 1.50663821120222e-09 NA NA NA hsa-miR-200c-3p GPM6A 3.50132673580082 2.42716349086937e-15 -4.42956657098415 1.14589092196157e-14 miRNATAP -0.612078374655501 3.81550733224843e-25 NA NA NA hsa-miR-200c-3p GREM1 3.50132673580082 2.42716349086937e-15 0.08752650759248 0.914525538097529 MirTarget -0.651094007307394 5.51115376486247e-15 NA NA NA hsa-miR-200c-3p HLF 3.50132673580082 2.42716349086937e-15 -5.48181644757567 4.24267397704754e-28 MirTarget;miRNATAP -0.598575582470935 4.30883090987262e-30 NA NA NA hsa-miR-200c-3p HS3ST3A1 3.50132673580082 2.42716349086937e-15 -0.129308279745747 0.831566302453219 MirTarget -0.629342883381929 2.19650792869416e-25 NA NA NA hsa-miR-200c-3p IGSF10 3.50132673580082 2.42716349086937e-15 -5.30237641574688 9.03000767899905e-16 MirTarget -0.543470626925824 8.24252002226486e-15 NA NA NA hsa-miR-200c-3p IL6ST 3.50132673580082 2.42716349086937e-15 -2.09967019941458 1.93264814611531e-05 mirMAP -0.351735931542591 6.11651430778903e-12 NA NA NA hsa-miR-200c-3p ITGA1 3.50132673580082 2.42716349086937e-15 -1.43194652766846 3.62878143052896e-06 MirTarget -0.340248985237553 3.10844394076231e-28 NA NA NA hsa-miR-200c-3p ITPR1 3.50132673580082 2.42716349086937e-15 -2.58213364075087 3.81753054779227e-18 miRNATAP -0.31074820203156 1.2207549117247e-23 NA NA NA hsa-miR-200c-3p JAZF1 3.50132673580082 2.42716349086937e-15 -1.91995536790338 5.72076669427973e-12 MirTarget;miRNATAP -0.417363984218602 1.18716870274506e-56 NA NA NA hsa-miR-200c-3p KCNK2 3.50132673580082 2.42716349086937e-15 -3.96205468288205 7.92099572968654e-12 miRNATAP -0.50213809450649 1.09916918435836e-16 NA NA NA hsa-miR-200c-3p KCNQ4 3.50132673580082 2.42716349086937e-15 -2.63982014948538 9.7947726847549e-09 miRNATAP -0.358302675169609 9.31183107328647e-14 NA NA NA hsa-miR-200c-3p KIAA1462 3.50132673580082 2.42716349086937e-15 -1.7207439664468 1.06773819784283e-07 MirTarget -0.390952395751051 2.06195319565717e-34 NA NA NA hsa-miR-200c-3p KLF9 3.50132673580082 2.42716349086937e-15 -2.78806270116525 1.14874620908535e-18 miRNAWalker2_validate;miRTarBase;miRNATAP -0.399931620637291 7.36174043539773e-36 NA NA NA hsa-miR-200c-3p LHFP 3.50132673580082 2.42716349086937e-15 -1.83125704677191 4.20141501543429e-10 MirTarget;miRNATAP -0.360296521299789 2.49193500017075e-35 NA NA NA hsa-miR-200c-5p LINGO2 2.95761105443819 3.11105707262802e-11 -1.99110914968633 0.00050913147948199 MirTarget -0.317887211986009 7.81424038567291e-07 NA NA NA hsa-miR-200c-3p LIX1L 3.50132673580082 2.42716349086937e-15 -1.29493279298234 2.01115053124561e-08 MirTarget -0.343384608216057 3.2644648024768e-57 NA NA NA hsa-miR-200c-3p MAF 3.50132673580082 2.42716349086937e-15 -1.28341922239874 0.00015825213662883 miRNATAP -0.35679417285462 9.60044419984967e-26 NA NA NA hsa-miR-200c-5p MAP1B 2.95761105443819 3.11105707262802e-11 -3.18358434812783 4.83606017602339e-16 miRNATAP -0.558765111274118 3.77141417498187e-41 NA NA NA hsa-miR-200c-5p MEF2C 2.95761105443819 3.11105707262802e-11 -2.13436808535659 1.07833769123274e-14 MirTarget -0.399158758331012 4.6703090597844e-43 NA NA NA hsa-miR-200c-3p MFAP5 3.50132673580082 2.42716349086937e-15 -4.35255383201982 2.63926165947326e-07 miRNATAP -0.904430228024108 2.48772724952338e-26 NA NA NA hsa-miR-200c-3p MITF 3.50132673580082 2.42716349086937e-15 -2.11043666647908 2.14681139044162e-09 miRNATAP -0.370919113758088 3.74236352265043e-25 NA NA NA hsa-miR-200c-3p MMD 3.50132673580082 2.42716349086937e-15 -0.0500962943374854 0.870546787744501 miRNATAP -0.308170884248988 9.44343148595576e-24 NA NA NA hsa-miR-200c-3p MRVI1 3.50132673580082 2.42716349086937e-15 -3.20095302741943 3.61514805440821e-17 MirTarget -0.427481623224712 8.25619928188081e-28 NA NA NA hsa-miR-200c-3p MSN 3.50132673580082 2.42716349086937e-15 -0.85546319996218 0.0136615174636227 miRNAWalker2_validate;miRTarBase;MirTarget -0.394048408331182 7.19357787283363e-31 NA NA NA hsa-miR-200c-3p MSRB3 3.50132673580082 2.42716349086937e-15 -3.32124931554379 1.17358848755899e-14 mirMAP -0.636225939222873 9.31523742862297e-54 NA NA NA hsa-miR-200c-5p MSRB3 2.95761105443819 3.11105707262802e-11 -3.32124931554379 1.17358848755899e-14 MirTarget -0.702161519322694 1.64952370143767e-58 NA NA NA hsa-miR-200c-3p NCAM1 3.50132673580082 2.42716349086937e-15 -5.46812766536887 2.35522582039703e-18 miRTarBase -0.866990545789506 1.62442785889179e-44 NA NA NA hsa-miR-200c-3p NCS1 3.50132673580082 2.42716349086937e-15 -1.7356703955299 3.35229307090603e-12 miRNATAP -0.304535657151827 1.94257399715938e-34 NA NA NA hsa-miR-200c-3p NEGR1 3.50132673580082 2.42716349086937e-15 -4.77810063590076 6.81978052859699e-19 miRNATAP -0.681089626504163 8.64401576200308e-36 NA NA NA hsa-miR-200c-3p NFASC 3.50132673580082 2.42716349086937e-15 -2.95717922837883 4.31475260476481e-14 miRNATAP -0.304840184738999 2.10611001389752e-13 23185507 miR 200c targets a NF κB up regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer breast cancer hsa-miR-200c-3p NOG 3.50132673580082 2.42716349086937e-15 -1.04996957338848 0.0827224388167783 MirTarget;miRNATAP -0.376049889176797 2.18212060301929e-09 NA NA NA hsa-miR-200c-3p NOVA1 3.50132673580082 2.42716349086937e-15 -4.21914714578111 7.21315612695789e-16 MirTarget;miRNATAP -0.420421113341647 4.0648338601721e-14 NA NA NA hsa-miR-200c-3p NR3C1 3.50132673580082 2.42716349086937e-15 -1.29490546417786 3.89055618845506e-05 miRNATAP -0.314248714852543 4.66913145651316e-23 NA NA NA hsa-miR-200c-3p NRG1 3.50132673580082 2.42716349086937e-15 -1.2378190219847 0.0741741552249905 miRNATAP -0.385142513117602 1.00816945988738e-07 NA NA NA hsa-miR-200c-5p NRK 2.95761105443819 3.11105707262802e-11 -1.59201756985477 0.00509851223935162 miRNATAP -0.369887135679796 5.21405154942366e-09 NA NA NA hsa-miR-200c-3p NTRK2 3.50132673580082 2.42716349086937e-15 -3.4444884279512 9.02401971614574e-08 miRNAWalker2_validate;miRTarBase -0.558218294130396 5.1648144515451e-17 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-200c-3p PALM2-AKAP2 3.50132673580082 2.42716349086937e-15 -1.62425751829219 3.00539592164251e-07 miRNATAP -0.423109617127978 1.14386142925674e-43 NA NA NA hsa-miR-200c-3p PCDH10 3.50132673580082 2.42716349086937e-15 -3.23750023602778 3.50143209305191e-07 MirTarget -0.525549846290652 1.40969347650151e-15 NA NA NA hsa-miR-200c-3p PCSK2 3.50132673580082 2.42716349086937e-15 -6.63257584033356 1.5810712933526e-27 miRNATAP -0.387549940282484 1.11101205605129e-08 NA NA NA hsa-miR-200c-3p PDE5A 3.50132673580082 2.42716349086937e-15 -2.72242827068326 2.90742264752214e-19 miRNATAP -0.300696725838192 4.90943616505544e-21 NA NA NA hsa-miR-200c-3p PLCL1 3.50132673580082 2.42716349086937e-15 -2.35657424868599 1.25135556692163e-13 MirTarget -0.408828817205366 2.17160107267565e-38 NA NA NA hsa-miR-200c-3p PLXNA4 3.50132673580082 2.42716349086937e-15 -2.25456361904941 4.96438419774251e-05 miRNATAP -0.679926341659152 5.4086890819909e-36 NA NA NA hsa-miR-200c-3p PLXNC1 3.50132673580082 2.42716349086937e-15 -0.532339572840622 0.284697523094741 miRNATAP -0.428294069530617 2.38986484144414e-17 NA NA NA hsa-miR-200c-3p PPARGC1A 3.50132673580082 2.42716349086937e-15 -4.12246484079635 1.21340396096287e-10 mirMAP -0.483417114278318 7.39173001877038e-13 NA NA NA hsa-miR-200c-3p PPP2R2C 3.50132673580082 2.42716349086937e-15 -0.795459846555288 0.266159255773917 miRNATAP -0.306291787073106 4.49365552911052e-05 NA NA NA hsa-miR-200c-3p PRKAA2 3.50132673580082 2.42716349086937e-15 -3.1651157275578 4.06046613880045e-09 MirTarget -0.3165574137351 2.9537182424848e-08 NA NA NA hsa-miR-200c-3p PRKCB 3.50132673580082 2.42716349086937e-15 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.48715771688849 5.01263551249731e-25 NA NA NA hsa-miR-200c-3p PRKG1 3.50132673580082 2.42716349086937e-15 -3.08984703833363 4.55204333556294e-10 miRNATAP -0.562636021923416 1.62782418772395e-29 NA NA NA hsa-miR-200c-3p PTHLH 3.50132673580082 2.42716349086937e-15 -0.637337427958821 0.359541326845111 MirTarget -0.321174456367142 1.03989013458563e-05 NA NA NA hsa-miR-200c-3p PTPRD 3.50132673580082 2.42716349086937e-15 -3.62979486144354 1.88740064210481e-09 miRNAWalker2_validate -0.631789922953883 8.61910701410587e-25 NA NA NA hsa-miR-200c-3p PTPRZ1 3.50132673580082 2.42716349086937e-15 -3.06984706543687 0.00081651312572712 MirTarget;miRNATAP -0.421932299469652 1.27346651460668e-05 NA NA NA hsa-miR-200c-3p PYGO1 3.50132673580082 2.42716349086937e-15 -2.10178219794221 4.03238443886891e-05 mirMAP -0.410995557662133 7.28369892582507e-15 NA NA NA hsa-miR-200c-3p RASSF8 3.50132673580082 2.42716349086937e-15 -1.48887021923134 4.62579164697906e-06 miRNATAP -0.314866562878241 1.49954673919764e-21 NA NA NA hsa-miR-200c-3p RECK 3.50132673580082 2.42716349086937e-15 -2.38610578026315 7.82688892259109e-14 miRNATAP -0.450430701110267 5.413160156224e-48 27574450;24647918 MiR 200c promotes bladder cancer cell migration and invasion by directly targeting RECK; The luciferase reporter assay showed that RECK was a direct target of miR-200c;Finally we demonstrated that expression of miR-200c in H460 cells suppressed cell growth by targeting RECK followed by activation of the JNK signaling pathway and ER stress; Collectively these data show that miR-200c expression sensitizes H460 cells to RESV and this is likely due to RECK expression cell migration; bladder cancer;lung cancer hsa-miR-200c-3p REEP1 3.50132673580082 2.42716349086937e-15 -4.34753961523252 3.78306600846853e-15 MirTarget;miRNATAP -0.60798144951987 9.68205191169038e-27 NA NA NA hsa-miR-200c-3p RELN 3.50132673580082 2.42716349086937e-15 -4.70097153618157 2.41994737445055e-14 MirTarget -0.654129820157615 6.78543521649521e-25 NA NA NA hsa-miR-200c-5p RUNX1T1 2.95761105443819 3.11105707262802e-11 -3.29112409449622 2.69681218718585e-11 miRNATAP -0.650867617447207 2.8201625915763e-35 NA NA NA hsa-miR-200c-3p RUSC2 3.50132673580082 2.42716349086937e-15 -1.59852075923141 8.04308093421491e-11 miRNATAP -0.332927858785705 2.94321058698259e-44 NA NA NA hsa-miR-200c-5p SAMD4A 2.95761105443819 3.11105707262802e-11 -2.17607774370782 7.9670339471712e-12 mirMAP -0.371072851945373 7.70674380546558e-27 NA NA NA hsa-miR-200c-3p SCN3A 3.50132673580082 2.42716349086937e-15 -2.32699009748223 7.40591172107087e-07 mirMAP -0.315258532252987 1.58612630302652e-10 NA NA NA hsa-miR-200c-3p SCUBE3 3.50132673580082 2.42716349086937e-15 -2.48127471582544 2.66234551923326e-07 mirMAP -0.385334863448361 1.41921436053361e-14 NA NA NA hsa-miR-200c-3p SDC2 3.50132673580082 2.42716349086937e-15 -2.00706478458987 1.28300608152733e-09 miRNATAP -0.331251769489888 1.17181582498384e-22 NA NA NA hsa-miR-200c-3p SFMBT2 3.50132673580082 2.42716349086937e-15 -1.41454985454287 0.000416308526551551 mirMAP -0.349056411453125 1.56123571326781e-17 NA NA NA hsa-miR-200c-3p SGCD 3.50132673580082 2.42716349086937e-15 -3.54960120603853 1.88168939363754e-09 mirMAP -0.674570017915175 5.40649659440121e-30 NA NA NA hsa-miR-200c-3p SGIP1 3.50132673580082 2.42716349086937e-15 -0.435449323177095 0.231015167394361 MirTarget -0.324279345851272 1.23552072204793e-18 NA NA NA hsa-miR-200c-3p SHE 3.50132673580082 2.42716349086937e-15 -2.12174612226388 6.45456472105851e-13 mirMAP -0.346237361482731 2.73958243144482e-31 NA NA NA hsa-miR-200c-3p SIRPA 3.50132673580082 2.42716349086937e-15 -0.55339733363088 0.119266182012343 MirTarget -0.382259349502016 1.54540408894156e-27 NA NA NA hsa-miR-200c-3p SLC16A12 3.50132673580082 2.42716349086937e-15 -0.975164130666574 0.0455225768500397 mirMAP;miRNATAP -0.312853270378774 6.26610008780758e-10 NA NA NA hsa-miR-200c-3p SLC16A2 3.50132673580082 2.42716349086937e-15 -1.53927355158781 4.3817377775803e-06 miRNATAP -0.39526770609163 6.41326684117318e-33 NA NA NA hsa-miR-200c-5p SLC18A2 2.95761105443819 3.11105707262802e-11 -2.15025936730909 8.02147349359406e-07 MirTarget;miRNATAP -0.380588456442552 2.93718480746357e-15 NA NA NA hsa-miR-200c-3p SLC30A4 3.50132673580082 2.42716349086937e-15 -1.12863913918651 0.00370195756593126 mirMAP -0.373474811983133 1.75276250787592e-21 NA NA NA hsa-miR-200c-3p SLC6A17 3.50132673580082 2.42716349086937e-15 0.941104200796897 0.0568131902197341 mirMAP;miRNATAP -0.338531774539117 3.42406203332552e-11 NA NA NA hsa-miR-200c-5p SLIT3 2.95761105443819 3.11105707262802e-11 -3.59991978393086 7.98217561727376e-15 mirMAP -0.36271486907671 6.61876177978684e-12 NA NA NA hsa-miR-200c-3p SNAP25 3.50132673580082 2.42716349086937e-15 -1.14591384974572 0.0327342558924054 MirTarget;miRNATAP -0.463254365225422 2.23415552337194e-17 NA NA NA hsa-miR-200c-3p STARD8 3.50132673580082 2.42716349086937e-15 -1.75930604958348 9.33516853968586e-11 mirMAP -0.379204663888607 9.45016942553162e-48 NA NA NA hsa-miR-200c-3p SULF1 3.50132673580082 2.42716349086937e-15 0.171691676108908 0.757613998121678 MirTarget;miRNATAP -0.49902968093352 7.30785365573536e-19 NA NA NA hsa-miR-200c-3p SV2B 3.50132673580082 2.42716349086937e-15 -2.33341367960543 7.07116491599061e-05 mirMAP -0.600923702564399 2.71705555424813e-24 NA NA NA hsa-miR-200c-3p SYDE1 3.50132673580082 2.42716349086937e-15 -0.810810064122849 0.0022212919239998 MirTarget;miRNATAP -0.364874012707535 2.34902550550674e-48 NA NA NA hsa-miR-200c-3p SYT11 3.50132673580082 2.42716349086937e-15 -2.11616848018482 5.62916826382274e-11 mirMAP -0.470440774817395 4.40014158696989e-53 NA NA NA hsa-miR-200c-3p TBX18 3.50132673580082 2.42716349086937e-15 -2.20112491662338 0.00124808322159382 MirTarget -0.476341627053578 1.65785424624472e-11 NA NA NA hsa-miR-200c-3p TCF4 3.50132673580082 2.42716349086937e-15 -1.61270531688003 6.6047419057989e-09 mirMAP;miRNATAP -0.315861779424697 8.06031609720187e-30 NA NA NA hsa-miR-200c-3p TCF7L1 3.50132673580082 2.42716349086937e-15 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.321512044267134 2.09544895880279e-19 NA NA NA hsa-miR-200c-3p TFEC 3.50132673580082 2.42716349086937e-15 0.01663444290745 0.970577333140702 MirTarget -0.381763051019323 8.25525605424634e-17 NA NA NA hsa-miR-200c-3p THEMIS 3.50132673580082 2.42716349086937e-15 -1.30669866510856 0.0118699940008927 mirMAP -0.306491960115639 1.52135462691567e-08 NA NA NA hsa-miR-200c-3p TIMP2 3.50132673580082 2.42716349086937e-15 -1.7485334269093 7.3578966378154e-06 miRTarBase -0.476890623570835 8.82517913264524e-36 NA NA NA hsa-miR-200c-3p TUBB2A 3.50132673580082 2.42716349086937e-15 -0.677785072656842 0.0628952222897361 MirTarget;miRNATAP -0.301714284442487 4.90632032076582e-16 NA NA NA hsa-miR-200c-5p VASN 2.95761105443819 3.11105707262802e-11 -1.26886800454802 6.79900312831963e-05 MirTarget -0.328342431625237 1.75110086831041e-21 NA NA NA hsa-miR-200c-3p VAT1L 3.50132673580082 2.42716349086937e-15 -1.21093342860372 0.00422286393153055 MirTarget;miRNATAP -0.302839487155164 4.55742927477905e-12 NA NA NA hsa-miR-200c-3p WIPF1 3.50132673580082 2.42716349086937e-15 -1.36396473341553 1.25828143739996e-05 MirTarget;miRNATAP -0.423943530965805 5.3342529515542e-46 NA NA NA hsa-miR-200c-3p ZCCHC24 3.50132673580082 2.42716349086937e-15 -2.70719377368971 1.38525107553668e-17 MirTarget;miRNATAP -0.469547451027985 6.2189554143374e-53 NA NA NA hsa-miR-200c-3p ZDHHC15 3.50132673580082 2.42716349086937e-15 -2.821890119317 1.80193983474815e-08 MirTarget -0.368797952315401 2.17957524144729e-12 NA NA NA hsa-miR-200c-3p ZEB1 3.50132673580082 2.42716349086937e-15 -2.59416392469398 4.19342616481451e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.486626185857263 7.57364095800154e-58 27666124;24710933;23754305;24615544;24424572;24186205;21682933;22407310;27717206;23626803 miR 200c regulates crizotinib resistant ALK positive lung cancer cells by reversing epithelial mesenchymal transition via targeting ZEB1;miR-200c has been shown to regulate the epithelial-mesenchymal transition EMT by inhibiting ZEB1 and ZEB2 expression in breast cancer cells; This study further examined the role of miR-200c in the invasion and metastasis of breast cancer that goes beyond the regulation on ZEB1 and ZEB2 expression;Overexpression of miR-200c in SN12-PM6 and 786-0 cells was concurrent with downregulation of ZEB1 and upregulation of E-cadherin mRNA and protein; Thus our study demonstrated that miR-200c decreases the metastatic ability of renal carcinoma cells by upregulating E-cadherin through ZEB1 and that modulating the expression of miR-200c could influence Akt protein levels;MiR 200c suppresses TGF β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer; MiR-200c which was the most significantly downregulated miRNA in trastuzumab-resistant cells restored trastuzumab sensitivity and suppressed invasion of breast cancer cells by concurrently targeting ZNF217 a transcriptional activator of TGF-β and ZEB1 a known mediator of TGF-β signaling; Given the reported backward inhibition of miR-200c by ZEB1 ZNF217 also exerts a feedback suppression of miR-200c via TGF-β/ZEB1 signaling; Restoration of miR-200c silencing of ZEB1 or ZNF217 or blockade of TGF-β signaling increased trastuzumab sensitivity and suppressed invasiveness of breast cancer cells;Accordingly the enforced expression of miR-200c and mir-141 resulted in a significant upregulation in E-cadherin expression contrary to the significant downregulation in ZEB1 expression in 3 cell lines UTSCC-24A UTSCC-24B and UTSCC-6A cells;Furthermore miR-200c was found to be important in modulating ZEB1 upregulation by ERG;Of this family miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2 mediators of epithelial- mesenchymal transition;miR 200c inhibits invasion and migration in human colon cancer cells SW480/620 by targeting ZEB1; Among those dysregulated microRNAs miR-200c was speculated to inhibit metastasis by targeting ZEB1; Overexpression of miR-200c was concurrent with downregulation of ZEB1 mRNA and protein; Taken together our study demonstrated that miR-200c inhibits metastatic ability by targeting ZEB1 in colon cancer cells SW480/620 and suggested that modulation of miR-200c could serve as therapeutic tool for inhibiting metastasis in colorectal cancer;Epigenetic Silencing of miR 200c in Breast Cancer Is Associated with Aggressiveness and Is Modulated by ZEB1;Concomitant with the increase in miR-200b and miR-200c ZEB1 expression was decreased and cells appeared more epithelial in morphology and were sensitized to TAM and fulvestrant inhibition ;metastasis;;metastasis;drug resistance;;;;metastasis;; lung cancer;breast cancer;kidney renal cell cancer;breast cancer;head and neck cancer;prostate cancer;breast cancer;colon cancer;breast cancer;breast cancer hsa-miR-200c-3p ZEB2 3.50132673580082 2.42716349086937e-15 -2.26388876645177 1.13775147583663e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.505461667418299 3.51768104787574e-66 24710933;26935975;21682933;25052237;18925646;24885194 miR-200c has been shown to regulate the epithelial-mesenchymal transition EMT by inhibiting ZEB1 and ZEB2 expression in breast cancer cells; This study further examined the role of miR-200c in the invasion and metastasis of breast cancer that goes beyond the regulation on ZEB1 and ZEB2 expression;MicroRNA 200c inhibits the metastasis of non small cell lung cancer cells by targeting ZEB2 an epithelial mesenchymal transition regulator;Of this family miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2 mediators of epithelial- mesenchymal transition;miR 200c modulates ovarian cancer cell metastasis potential by targeting zinc finger E box binding homeobox 2 ZEB2 expression; Luciferase reporter assay confirmed the target of miR-200c as ZEB2; Furthermore miR-200c expression inhibited ovarian cancer cell ES-2 migration and invasion capacity by suppression of ZEB2 expression p < 0.01; Thus targeting of miR-200c or ZEB2 may serve as a potential therapeutic strategy for control of ovarian cancer;We established by quantitative RT-PCR that in CCCs in which miR-141 and miR-200c were down-regulated ZFHX1B a transcriptional repressor for CDH1/E-cadherin tended to be up-regulated; On the basis of these findings we suggest that down-regulation of miR-141 and miR-200c in CCCs might be involved in suppression of CDH1/E-cadherin transcription via up-regulation of ZFHX1B;Two gastric cancer cell lines were treated with IGF-I to induce EMT and levels of transcription factor ZEB2 and microRNA-200c miR-200c were measured; Furthermore both Akt/ERK inhibitors and knockdown of Akt/ERK gene reversed IGF-I-induced ZEB2 up-regulation and EMT through up-regulation of miR-200c suggesting the involvement of an Akt/ERK-miR-200c-ZEB2 axis in IGF-I-induced EMT metastasis;metastasis;;metastasis;; breast cancer;lung squamous cell cancer;breast cancer;ovarian cancer;kidney renal cell cancer;gastric cancer hsa-miR-200c-3p ZFHX4 3.50132673580082 2.42716349086937e-15 -2.72243653694716 1.46650038380412e-06 miRNATAP -0.601417439334846 3.8300230069112e-26 NA NA NA hsa-miR-200c-3p ZFPM2 3.50132673580082 2.42716349086937e-15 -3.29884457958359 4.34537841593148e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.611029488221047 1.66969606835284e-38 NA NA NA