miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-139-5p AKT3 -1.46099200329485 7.85040381494472e-22 0.757395805826156 5.24354425444781e-05 PITA;miRanda -0.204988506808972 7.26517518198736e-05 NA NA NA hsa-miR-15a-5p AKT3 0.783550182002274 2.60699595655907e-11 0.757395805826156 5.24354425444781e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265716982670402 0.000109391971495535 NA NA NA hsa-miR-17-5p AKT3 1.41924888736771 2.75805544953758e-18 0.757395805826156 5.24354425444781e-05 TargetScan;miRNATAP -0.210478431167346 1.46778910374435e-05 NA NA NA hsa-miR-205-3p AKT3 1.2960640797621 5.80786479909147e-11 0.757395805826156 5.24354425444781e-05 mirMAP -0.248708307357298 5.71786142986847e-10 NA NA NA hsa-miR-20a-5p AKT3 1.1531986665452 1.02385132917958e-11 0.757395805826156 5.24354425444781e-05 miRNATAP -0.244010493055021 2.19437052623105e-07 NA NA NA hsa-miR-29b-3p AKT3 -0.110721443686039 0.511264554091106 0.757395805826156 5.24354425444781e-05 miRNATAP -0.255169036216248 1.32894370465011e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-362-3p AKT3 -0.697212068252854 2.61718493418184e-06 0.757395805826156 5.24354425444781e-05 miRanda -0.198442787422331 0.000314248564221821 NA NA NA hsa-miR-362-5p AKT3 0.41089772861323 0.0404254902071382 0.757395805826156 5.24354425444781e-05 PITA;TargetScan;miRNATAP -0.156881795440952 0.000120211641903581 NA NA NA hsa-miR-146b-5p BRAF 0.917975986853978 3.33749259316025e-09 -0.278461879502222 0.00862922800492509 miRanda -0.198608471305069 5.60541065764218e-12 21874046;26883911;20406109;21537871 Additionally the activation of thyroid most common oncogenes RET/PTC3 and BRAF in PCCL3 cells upregulated miR-146b-5p expression;miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells independently from their original mutation either BRAF or RET/PTC through a mechanism that involves the actin cytoskeleton but not an increased capacity of matrix degradation;The miR-146b expression levels in PTCs with BRAF mutation were significantly higher than those without this mutation p < 0.0001;Among BRAF-positive tumors overexpression of miR-146b was associated with aggressive behavior suggesting that it may further refine the prognostic importance of BRAF ;;; thyroid cancer;thyroid cancer;thyroid cancer;thyroid cancer hsa-miR-191-5p BRAF 0.648528205617075 5.59342922179914e-07 -0.278461879502222 0.00862922800492509 miRNAWalker2_validate -0.142799724118867 5.20266670384239e-05 NA NA NA hsa-miR-590-3p BRAF 0.221436901462551 0.0965904764063157 -0.278461879502222 0.00862922800492509 miRanda -0.107424528492695 0.00201203820994774 NA NA NA hsa-miR-103a-3p CAB39 0.556219385347418 1.55815736455067e-09 -0.208958937519664 0.0665896026307357 MirTarget;miRNATAP -0.226715993581714 2.12351084443704e-05 NA NA NA hsa-miR-107 CAB39 -0.0447040564279497 0.671618791096755 -0.208958937519664 0.0665896026307357 MirTarget;miRanda;miRNATAP -0.126137925960192 0.00789923992994294 NA NA NA hsa-miR-15a-5p CAB39 0.783550182002274 2.60699595655907e-11 -0.208958937519664 0.0665896026307357 miRNATAP -0.117424344221392 0.00476208479848992 NA NA NA hsa-miR-15b-5p CAB39 0.85315666454713 3.79816274836297e-12 -0.208958937519664 0.0665896026307357 miRNATAP -0.283784749916631 2.76772460104827e-13 NA NA NA hsa-miR-16-5p CAB39 0.521122945828175 1.40561786410572e-06 -0.208958937519664 0.0665896026307357 miRNATAP -0.169588117333758 0.000204490721913869 NA NA NA hsa-miR-19b-3p CAB39 0.538732279378089 0.000622008277870679 -0.208958937519664 0.0665896026307357 MirTarget;miRNATAP -0.107463699551926 0.000609933394484493 NA NA NA hsa-miR-200b-3p CAB39 0.0717138787925347 0.682858087587209 -0.208958937519664 0.0665896026307357 MirTarget;TargetScan -0.162767336987454 5.80508721953959e-09 NA NA NA hsa-miR-200c-3p CAB39 0.630251054099546 0.000131975031451555 -0.208958937519664 0.0665896026307357 MirTarget;miRNATAP -0.140030258128429 2.49638228629011e-06 NA NA NA hsa-miR-23b-3p CAB39 -0.497563803223134 3.31483353357535e-05 -0.208958937519664 0.0665896026307357 MirTarget;miRNATAP -0.176075537548793 1.83370057110902e-05 NA NA NA hsa-miR-27b-3p CAB39 -0.732682718863563 2.26896143573324e-09 -0.208958937519664 0.0665896026307357 MirTarget;miRNATAP -0.182433892170215 4.49688462221706e-06 NA NA NA hsa-miR-320a CAB39 0.801356001806321 4.91397101474502e-09 -0.208958937519664 0.0665896026307357 MirTarget;PITA;miRanda;miRNATAP -0.214106643659412 1.30340667223272e-09 NA NA NA hsa-miR-320b CAB39 1.23473838180754 3.04337566045537e-14 -0.208958937519664 0.0665896026307357 MirTarget;PITA;miRanda;miRNATAP -0.184541356762053 3.08349381419598e-10 NA NA NA hsa-miR-335-3p CAB39 0.336785882180547 0.0542446207938138 -0.208958937519664 0.0665896026307357 MirTarget;mirMAP -0.253640555285378 1.62478138605231e-20 NA NA NA hsa-miR-33a-3p CAB39 0.20371038027126 0.212335697664505 -0.208958937519664 0.0665896026307357 miRNATAP -0.105229696283965 0.000637298528712565 NA NA NA hsa-miR-374a-5p CAB39 -0.621903385111545 6.61791773205282e-12 -0.208958937519664 0.0665896026307357 mirMAP -0.157150293240261 0.00375669688536463 NA NA NA hsa-miR-374b-3p CAB39 0.425603499218802 0.00146686864653282 -0.208958937519664 0.0665896026307357 MirTarget -0.136860793934122 0.000227258196411566 NA NA NA hsa-miR-374b-5p CAB39 -0.288413933608091 0.0041474558664058 -0.208958937519664 0.0665896026307357 mirMAP -0.280351643751934 1.08071729388595e-08 NA NA NA hsa-miR-429 CAB39 0.559451508722375 0.00563641638673083 -0.208958937519664 0.0665896026307357 MirTarget;PITA;miRanda;miRNATAP -0.141886855127545 4.29801233595198e-09 NA NA NA hsa-miR-497-5p CAB39 -0.966244470847844 5.26505649147857e-12 -0.208958937519664 0.0665896026307357 miRNATAP -0.154569249251912 7.72832546995339e-06 NA NA NA hsa-miR-550a-5p CAB39 1.48775474412835 6.14204462566372e-18 -0.208958937519664 0.0665896026307357 MirTarget -0.162054381319594 3.67178927201425e-09 NA NA NA hsa-miR-214-5p CAB39L 0.236510288548811 0.206226406026677 -2.27660482934059 3.0860484890564e-59 MirTarget -0.11017183960811 0.00275640595919508 NA NA NA hsa-miR-342-3p CAB39L 0.99756868977753 9.28499866272332e-10 -2.27660482934059 3.0860484890564e-59 miRanda -0.171267942389552 3.56103599915494e-05 NA NA NA hsa-miR-34b-3p CAB39L 1.05595687443274 4.36830248743191e-05 -2.27660482934059 3.0860484890564e-59 MirTarget -0.10019611462181 0.000199480445568756 NA NA NA hsa-miR-542-3p CAB39L 0.643308814904977 8.81635403230104e-07 -2.27660482934059 3.0860484890564e-59 miRanda -0.257742769138029 6.72884347103324e-07 NA NA NA hsa-miR-590-5p CAB39L 0.763025362395968 3.65305892505623e-09 -2.27660482934059 3.0860484890564e-59 miRanda -0.289784204942081 2.6042892813158e-08 NA NA NA hsa-miR-7-1-3p CAB39L 1.13646121619622 1.49823237535933e-14 -2.27660482934059 3.0860484890564e-59 mirMAP -0.282907536222823 2.61238495902577e-10 NA NA NA hsa-miR-101-3p DDIT4 -1.91263766544878 1.50270129259053e-39 0.970744345695446 1.21158401060779e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.342380259239773 5.91047029457662e-10 NA NA NA hsa-miR-139-5p DDIT4 -1.46099200329485 7.85040381494472e-22 0.970744345695446 1.21158401060779e-06 MirTarget;miRanda;miRNATAP -0.327281605694535 2.42764419386966e-09 NA NA NA hsa-miR-181c-5p DDIT4 -0.168991199007857 0.196949106150297 0.970744345695446 1.21158401060779e-06 MirTarget -0.257540521853273 0.000130092784283203 NA NA NA hsa-miR-217 DDIT4 -1.35391381055929 2.42394951427902e-09 0.970744345695446 1.21158401060779e-06 miRanda -0.153215259980346 5.55175086608736e-05 NA NA NA hsa-miR-30a-5p DDIT4 -1.79779915425811 1.93360169837799e-26 0.970744345695446 1.21158401060779e-06 MirTarget;miRNATAP -0.154401827902412 0.00180557215482945 NA NA NA hsa-miR-30e-5p DDIT4 -1.02114836019762 6.81961221797866e-17 0.970744345695446 1.21158401060779e-06 MirTarget -0.379303698849891 4.53009508603041e-08 NA NA NA hsa-miR-103a-3p EIF4B 0.556219385347418 1.55815736455067e-09 -0.62641897565296 1.23387091054055e-17 MirTarget;miRNATAP -0.117931433458342 0.000882954422210039 NA NA NA hsa-miR-15a-5p EIF4B 0.783550182002274 2.60699595655907e-11 -0.62641897565296 1.23387091054055e-17 miRNATAP -0.122377717206467 8.05532422543555e-06 NA NA NA hsa-miR-330-5p EIF4B 0.944693925383906 5.04972895657346e-13 -0.62641897565296 1.23387091054055e-17 miRNATAP -0.114130410687731 3.14202972751022e-06 NA NA NA hsa-miR-342-3p EIF4B 0.99756868977753 9.28499866272332e-10 -0.62641897565296 1.23387091054055e-17 miRanda -0.115015800194979 4.52869018419104e-09 NA NA NA hsa-miR-423-3p EIF4B 1.20230884409188 2.57129723627633e-23 -0.62641897565296 1.23387091054055e-17 miRNAWalker2_validate -0.123647038118901 1.86691163614015e-06 NA NA NA hsa-miR-25-3p EIF4E 0.76549796417801 3.32282098247097e-11 -0.262933625196079 0.00112545782482932 mirMAP -0.13676892354679 4.72116978925783e-06 NA NA NA hsa-miR-28-3p EIF4E 0.459875450032895 3.47095927872566e-07 -0.262933625196079 0.00112545782482932 mirMAP -0.15736763735348 5.16597820364993e-05 NA NA NA hsa-miR-30e-3p EIF4E -0.890635378639789 1.65740480611339e-16 -0.262933625196079 0.00112545782482932 mirMAP -0.131874726474787 3.12004490511946e-05 NA NA NA hsa-miR-340-5p EIF4E -0.608415693437977 4.44345153563513e-05 -0.262933625196079 0.00112545782482932 mirMAP -0.126944928816917 4.86525017462016e-08 NA NA NA hsa-miR-107 EIF4E2 -0.0447040564279497 0.671618791096755 -0.0413779426413807 0.591787741861913 miRanda -0.153727110860332 1.32120346723983e-06 NA NA NA hsa-miR-98-5p EIF4E2 0.0176698653376732 0.858271091070735 -0.0413779426413807 0.591787741861913 miRNAWalker2_validate -0.100046147489821 0.00341364300236721 NA NA NA hsa-miR-125b-5p EIF4EBP1 -0.993460109818276 5.07736727659894e-12 0.639128163333169 3.30033718127171e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.246150133132689 6.70763452586795e-08 17891175;26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ; prostate cancer;ovarian cancer hsa-miR-328-3p EIF4EBP1 0.153404163477345 0.292356842798574 0.639128163333169 3.30033718127171e-05 MirTarget -0.122043464998929 0.0087183508792019 NA NA NA hsa-miR-106a-5p HIF1A 0.67978010057847 0.00221925869726092 0.669817670907295 4.04045371604487e-06 MirTarget -0.137115422426195 1.39355599414074e-06 NA NA NA hsa-miR-106b-5p HIF1A 0.50378717276868 1.45412404526866e-05 0.669817670907295 4.04045371604487e-06 MirTarget -0.223349543954752 4.34799162298509e-05 NA NA NA hsa-miR-139-5p HIF1A -1.46099200329485 7.85040381494472e-22 0.669817670907295 4.04045371604487e-06 miRanda -0.14857437469501 0.00021959685216009 NA NA NA hsa-miR-155-5p HIF1A 0.533437622040649 0.00248671179205372 0.669817670907295 4.04045371604487e-06 MirTarget -0.166095452335493 3.6975721543014e-06 NA NA NA hsa-miR-16-2-3p HIF1A 1.1567130855258 1.01867256952189e-14 0.669817670907295 4.04045371604487e-06 MirTarget;mirMAP -0.155181425894773 0.000187446199797176 NA NA NA hsa-miR-195-3p HIF1A -0.624259620429699 0.000164279659144497 0.669817670907295 4.04045371604487e-06 MirTarget -0.175041579623075 4.99936198652015e-06 NA NA NA hsa-miR-199b-5p HIF1A -1.08432682485992 7.68241801134089e-10 0.669817670907295 4.04045371604487e-06 miRNAWalker2_validate;miRTarBase;MirTarget;PITA;miRanda -0.11461751152829 0.00128710247227163 NA NA NA hsa-miR-20a-5p HIF1A 1.1531986665452 1.02385132917958e-11 0.669817670907295 4.04045371604487e-06 miRNAWalker2_validate;miRTarBase;MirTarget -0.116299660018667 0.00162371994354084 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-20b-5p HIF1A 0.345967670847176 0.232014828043601 0.669817670907295 4.04045371604487e-06 miRNAWalker2_validate;miRTarBase;MirTarget -0.152996396065526 1.46287359054023e-12 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-217 HIF1A -1.35391381055929 2.42394951427902e-09 0.669817670907295 4.04045371604487e-06 miRanda -0.183594478859186 1.44847944599925e-11 NA NA NA hsa-miR-320a HIF1A 0.801356001806321 4.91397101474502e-09 0.669817670907295 4.04045371604487e-06 miRanda -0.230969351823761 4.30112041238924e-07 NA NA NA hsa-miR-338-3p HIF1A -0.948755228846395 8.99167125682392e-08 0.669817670907295 4.04045371604487e-06 MirTarget;PITA;miRanda -0.190220299615109 6.54196374682613e-08 NA NA NA hsa-miR-582-3p HIF1A -0.248056267546012 0.143798829508405 0.669817670907295 4.04045371604487e-06 PITA -0.233016344117027 3.43396124378489e-10 NA NA NA hsa-miR-582-5p HIF1A -0.0366995972742474 0.821827119138923 0.669817670907295 4.04045371604487e-06 MirTarget;PITA;miRNATAP -0.219823611189094 1.51379253741892e-08 NA NA NA hsa-miR-660-5p HIF1A -0.202705992887645 0.101093376073573 0.669817670907295 4.04045371604487e-06 MirTarget -0.302515707563253 3.56530783679055e-09 NA NA NA hsa-miR-93-5p HIF1A 1.61042951896619 5.1280369606967e-24 0.669817670907295 4.04045371604487e-06 MirTarget -0.136543492976145 0.00035313377854799 NA NA NA hsa-let-7a-3p IGF1 0.0966652362351867 0.423761916840503 -1.83606554417213 4.89445874007951e-10 mirMAP -0.628414381189287 5.27761426031282e-09 NA NA NA hsa-miR-103a-2-5p IGF1 1.37988337975616 6.74852943995612e-08 -1.83606554417213 4.89445874007951e-10 mirMAP -0.45438875584609 1.7540230331713e-17 NA NA NA hsa-miR-130a-3p IGF1 0.67051191119964 4.89747518735144e-06 -1.83606554417213 4.89445874007951e-10 MirTarget -0.700417159997035 4.55001564446877e-16 NA NA NA hsa-miR-130b-3p IGF1 1.44628430084411 9.13980959861273e-24 -1.83606554417213 4.89445874007951e-10 MirTarget -0.381225145442848 1.06880616791146e-05 NA NA NA hsa-miR-15b-3p IGF1 1.05020782493504 6.38723677324836e-14 -1.83606554417213 4.89445874007951e-10 mirMAP -0.600110692355124 2.35788363622271e-11 NA NA NA hsa-miR-16-1-3p IGF1 0.955017760172879 5.95379292601146e-11 -1.83606554417213 4.89445874007951e-10 mirMAP -0.654262965462375 3.52738431783344e-14 NA NA NA hsa-miR-186-5p IGF1 0.353452958261612 0.000145058448579496 -1.83606554417213 4.89445874007951e-10 mirMAP -0.366692143669484 0.00959838552779203 NA NA NA hsa-miR-19a-3p IGF1 1.35800152353624 2.80940447111944e-12 -1.83606554417213 4.89445874007951e-10 MirTarget -0.675360942734142 3.91550460498543e-27 NA NA NA hsa-miR-19b-1-5p IGF1 0.757034032029085 2.99828133413343e-07 -1.83606554417213 4.89445874007951e-10 mirMAP -0.699245326551041 2.59396405008731e-16 NA NA NA hsa-miR-19b-3p IGF1 0.538732279378089 0.000622008277870679 -1.83606554417213 4.89445874007951e-10 MirTarget -0.750279055807441 5.4834038782256e-21 NA NA NA hsa-miR-205-3p IGF1 1.2960640797621 5.80786479909147e-11 -1.83606554417213 4.89445874007951e-10 mirMAP -0.600295652502196 5.84026535331867e-22 NA NA NA hsa-miR-20a-3p IGF1 1.34885093664027 2.07697464119202e-12 -1.83606554417213 4.89445874007951e-10 mirMAP -0.573755673684406 5.83753051386334e-19 NA NA NA hsa-miR-224-3p IGF1 0.502645536188015 0.0081142387260641 -1.83606554417213 4.89445874007951e-10 mirMAP -0.397083320323672 6.59448390538765e-09 NA NA NA hsa-miR-27a-3p IGF1 0.348456440505425 0.00126682892514312 -1.83606554417213 4.89445874007951e-10 miRNAWalker2_validate;miRTarBase -0.630796790452773 1.61575924809895e-07 NA NA NA hsa-miR-301a-3p IGF1 2.14132004241926 4.46255413526808e-25 -1.83606554417213 4.89445874007951e-10 MirTarget -0.542962161756586 7.28279283702467e-21 NA NA NA hsa-miR-320a IGF1 0.801356001806321 4.91397101474502e-09 -1.83606554417213 4.89445874007951e-10 miRNATAP -0.471166482627833 4.87790750232857e-07 NA NA NA hsa-miR-320b IGF1 1.23473838180754 3.04337566045537e-14 -1.83606554417213 4.89445874007951e-10 miRNATAP -0.435970586012069 1.99260325159595e-08 NA NA NA hsa-miR-33a-3p IGF1 0.20371038027126 0.212335697664505 -1.83606554417213 4.89445874007951e-10 MirTarget -0.301086727433913 0.000210494168325812 NA NA NA hsa-miR-3607-3p IGF1 1.01377165357363 9.13355519701165e-05 -1.83606554417213 4.89445874007951e-10 mirMAP -0.279152595145872 1.84181237021726e-08 NA NA NA hsa-miR-362-5p IGF1 0.41089772861323 0.0404254902071382 -1.83606554417213 4.89445874007951e-10 mirMAP -0.266319117984938 4.10437106471054e-05 NA NA NA hsa-miR-450b-5p IGF1 1.25529820885833 1.18847120528666e-15 -1.83606554417213 4.89445874007951e-10 MirTarget;PITA;mirMAP;miRNATAP -0.248366118573042 0.00221127559765416 NA NA NA hsa-miR-452-5p IGF1 0.373288744398455 0.0348485937209964 -1.83606554417213 4.89445874007951e-10 MirTarget;mirMAP -0.266246297258034 0.000308015705405959 NA NA NA hsa-miR-454-3p IGF1 1.54137391927201 4.15861570449376e-20 -1.83606554417213 4.89445874007951e-10 MirTarget -0.626033221014056 8.04576753877952e-18 NA NA NA hsa-miR-576-5p IGF1 0.940432050128373 6.90227595663302e-12 -1.83606554417213 4.89445874007951e-10 PITA;mirMAP;miRNATAP -0.73695380930135 6.7749669820951e-16 NA NA NA hsa-miR-590-3p IGF1 0.221436901462551 0.0965904764063157 -1.83606554417213 4.89445874007951e-10 MirTarget;miRanda;mirMAP;miRNATAP -0.293536383987437 0.00288981376091861 NA NA NA hsa-miR-629-5p IGF1 0.461215538037447 8.95262667860215e-06 -1.83606554417213 4.89445874007951e-10 mirMAP -0.473288980212107 0.00016595454212857 NA NA NA hsa-miR-940 IGF1 1.25303020594374 1.3005368359451e-10 -1.83606554417213 4.89445874007951e-10 MirTarget;PITA;miRNATAP -0.179832112337034 0.00706374566547861 NA NA NA hsa-miR-130a-3p MAPK1 0.67051191119964 4.89747518735144e-06 -0.0253189255173565 0.755655647597946 mirMAP -0.119879003954416 4.21355197025158e-07 NA NA NA hsa-miR-140-5p MAPK1 -0.412389003031485 0.000136051708543369 -0.0253189255173565 0.755655647597946 miRanda -0.106820947603036 0.00107357303022432 NA NA NA hsa-miR-16-2-3p MAPK1 1.1567130855258 1.01867256952189e-14 -0.0253189255173565 0.755655647597946 mirMAP -0.118882902026294 1.87389146405289e-07 NA NA NA hsa-miR-19a-3p MAPK1 1.35800152353624 2.80940447111944e-12 -0.0253189255173565 0.755655647597946 mirMAP -0.108060075233242 6.73894767696324e-10 NA NA NA hsa-miR-19b-3p MAPK1 0.538732279378089 0.000622008277870679 -0.0253189255173565 0.755655647597946 mirMAP -0.153151975431285 2.83628955522989e-12 NA NA NA hsa-miR-24-1-5p MAPK1 -0.0503110566834755 0.742860080224713 -0.0253189255173565 0.755655647597946 mirMAP -0.116961525723256 3.20301669196585e-07 NA NA NA hsa-miR-29a-5p MAPK1 0.323252792625584 0.0370417231222825 -0.0253189255173565 0.755655647597946 mirMAP -0.100820598289556 8.60387631678624e-06 NA NA NA hsa-miR-29b-2-5p MAPK1 -0.502720326849742 0.000730448246894952 -0.0253189255173565 0.755655647597946 mirMAP -0.143966940664653 6.76991395724673e-10 NA NA NA hsa-miR-29b-3p MAPK1 -0.110721443686039 0.511264554091106 -0.0253189255173565 0.755655647597946 mirMAP -0.155562785937532 3.13794270245465e-14 NA NA NA hsa-miR-30b-5p MAPK1 -0.400238605368173 0.00346540992719245 -0.0253189255173565 0.755655647597946 mirMAP -0.174014396815711 6.15963591886978e-12 NA NA NA hsa-miR-30c-5p MAPK1 0.021222006155897 0.886366656528128 -0.0253189255173565 0.755655647597946 mirMAP -0.16816380351527 6.00043626518046e-13 NA NA NA hsa-miR-30d-3p MAPK1 -0.577371911152798 2.02950840095287e-06 -0.0253189255173565 0.755655647597946 mirMAP -0.122142266216853 2.26778585246636e-05 NA NA NA hsa-miR-32-5p MAPK1 -0.317310201890053 0.0102525324475293 -0.0253189255173565 0.755655647597946 mirMAP -0.118206616474112 3.38014161673994e-05 NA NA NA hsa-miR-320a MAPK1 0.801356001806321 4.91397101474502e-09 -0.0253189255173565 0.755655647597946 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.125451646590753 6.80368047080733e-07 NA NA NA hsa-miR-338-3p MAPK1 -0.948755228846395 8.99167125682392e-08 -0.0253189255173565 0.755655647597946 miRanda -0.129835880343114 1.75257870680844e-11 NA NA NA hsa-miR-342-3p MAPK1 0.99756868977753 9.28499866272332e-10 -0.0253189255173565 0.755655647597946 miRanda;mirMAP -0.169189955454587 3.43413416819006e-16 NA NA NA hsa-miR-34a-5p MAPK1 -0.117372471043915 0.364001947180738 -0.0253189255173565 0.755655647597946 mirMAP -0.233668876576953 1.32503113597025e-18 NA NA NA hsa-miR-362-3p MAPK1 -0.697212068252854 2.61718493418184e-06 -0.0253189255173565 0.755655647597946 mirMAP -0.110141441408008 2.93292282524057e-06 NA NA NA hsa-miR-362-5p MAPK1 0.41089772861323 0.0404254902071382 -0.0253189255173565 0.755655647597946 mirMAP -0.144103835470426 3.00694449777536e-17 NA NA NA hsa-miR-374a-3p MAPK1 -0.299190081500425 0.00682975596757891 -0.0253189255173565 0.755655647597946 mirMAP -0.110281311853038 0.000567634401408648 NA NA NA hsa-miR-374b-5p MAPK1 -0.288413933608091 0.0041474558664058 -0.0253189255173565 0.755655647597946 mirMAP -0.193539977082972 2.99670270207311e-08 NA NA NA hsa-miR-454-3p MAPK1 1.54137391927201 4.15861570449376e-20 -0.0253189255173565 0.755655647597946 mirMAP -0.134566799939584 1.33034028771569e-11 NA NA NA hsa-miR-500a-3p MAPK1 0.457959128173392 0.000691656736597067 -0.0253189255173565 0.755655647597946 mirMAP -0.181280312300052 1.44783347897454e-12 NA NA NA hsa-miR-501-3p MAPK1 0.820141346319976 1.74562930463389e-08 -0.0253189255173565 0.755655647597946 mirMAP -0.113690992046206 1.83281067549205e-06 NA NA NA hsa-miR-501-5p MAPK1 1.02806906860218 1.63456814370548e-09 -0.0253189255173565 0.755655647597946 mirMAP -0.102516454465174 5.70704874257852e-07 NA NA NA hsa-miR-502-3p MAPK1 -0.165138869760313 0.106881047403914 -0.0253189255173565 0.755655647597946 mirMAP -0.118442041096273 0.000641376645364786 NA NA NA hsa-miR-505-3p MAPK1 0.912823669571645 4.0549774967148e-13 -0.0253189255173565 0.755655647597946 mirMAP -0.112388892923579 4.07425901957411e-05 NA NA NA hsa-miR-660-5p MAPK1 -0.202705992887645 0.101093376073573 -0.0253189255173565 0.755655647597946 mirMAP -0.195287313401534 3.91978206929352e-12 NA NA NA hsa-miR-320b MAPK3 1.23473838180754 3.04337566045537e-14 -0.858383500175909 4.87731698141196e-21 miRNAWalker2_validate -0.150409382751881 7.4168687441981e-10 NA NA NA hsa-miR-34a-5p MAPK3 -0.117372471043915 0.364001947180738 -0.858383500175909 4.87731698141196e-21 miRNAWalker2_validate -0.142473103912921 8.01686085043296e-06 NA NA NA hsa-miR-423-3p MAPK3 1.20230884409188 2.57129723627633e-23 -0.858383500175909 4.87731698141196e-21 miRNAWalker2_validate -0.111095021124406 0.000694439178470412 NA NA NA hsa-miR-423-5p MAPK3 0.60141781325829 1.62940950644999e-07 -0.858383500175909 4.87731698141196e-21 miRNATAP -0.162814696094577 4.59419685322422e-06 NA NA NA hsa-miR-542-3p MAPK3 0.643308814904977 8.81635403230104e-07 -0.858383500175909 4.87731698141196e-21 miRanda -0.109224164762627 0.000481993746155519 NA NA NA hsa-miR-103a-3p PDPK1 0.556219385347418 1.55815736455067e-09 -0.374841923318686 0.000672007355166274 mirMAP -0.29017497623463 1.7103988105315e-08 NA NA NA hsa-miR-125a-5p PDPK1 0.215366061934933 0.119550904549401 -0.374841923318686 0.000672007355166274 miRNAWalker2_validate;mirMAP -0.20458547523825 2.96393173254167e-09 NA NA NA hsa-miR-130b-5p PDPK1 1.77265255049999 1.43627774829684e-29 -0.374841923318686 0.000672007355166274 mirMAP -0.118592255898703 3.97903467320827e-05 NA NA NA hsa-miR-148b-5p PDPK1 1.1533193737265 7.26420964688337e-13 -0.374841923318686 0.000672007355166274 mirMAP -0.159957807676691 5.21685211952077e-08 NA NA NA hsa-miR-15a-5p PDPK1 0.783550182002274 2.60699595655907e-11 -0.374841923318686 0.000672007355166274 mirMAP -0.310907696179115 2.89097442842771e-15 NA NA NA hsa-miR-17-5p PDPK1 1.41924888736771 2.75805544953758e-18 -0.374841923318686 0.000672007355166274 miRNAWalker2_validate;mirMAP -0.188610500072922 2.00392592187993e-11 NA NA NA hsa-miR-186-5p PDPK1 0.353452958261612 0.000145058448579496 -0.374841923318686 0.000672007355166274 mirMAP -0.227196548230479 1.15125913292726e-05 NA NA NA hsa-miR-197-3p PDPK1 0.878693269130833 3.84847526014135e-15 -0.374841923318686 0.000672007355166274 mirMAP -0.143504954220919 0.000651631392166555 NA NA NA hsa-miR-20a-5p PDPK1 1.1531986665452 1.02385132917958e-11 -0.374841923318686 0.000672007355166274 mirMAP -0.196318407478492 6.24384965065394e-13 NA NA NA hsa-miR-22-5p PDPK1 0.706731861922839 3.44318705980007e-07 -0.374841923318686 0.000672007355166274 miRNATAP -0.195090596012909 1.0156148239318e-08 NA NA NA hsa-miR-2355-5p PDPK1 1.47205546931107 8.65192179636668e-19 -0.374841923318686 0.000672007355166274 mirMAP -0.141891966150004 3.11854262455652e-07 NA NA NA hsa-miR-29b-3p PDPK1 -0.110721443686039 0.511264554091106 -0.374841923318686 0.000672007355166274 mirMAP -0.153513947978287 6.08833428400365e-08 NA NA NA hsa-miR-320a PDPK1 0.801356001806321 4.91397101474502e-09 -0.374841923318686 0.000672007355166274 miRanda -0.182840502373476 1.08171028199283e-07 NA NA NA hsa-miR-338-3p PDPK1 -0.948755228846395 8.99167125682392e-08 -0.374841923318686 0.000672007355166274 mirMAP -0.129012328728478 1.2622962488162e-06 NA NA NA hsa-miR-342-3p PDPK1 0.99756868977753 9.28499866272332e-10 -0.374841923318686 0.000672007355166274 mirMAP -0.183826709476054 1.400623732691e-10 NA NA NA hsa-miR-374a-3p PDPK1 -0.299190081500425 0.00682975596757891 -0.374841923318686 0.000672007355166274 mirMAP -0.151744661636615 0.00051129283675243 NA NA NA hsa-miR-374b-5p PDPK1 -0.288413933608091 0.0041474558664058 -0.374841923318686 0.000672007355166274 miRNATAP -0.205234606123058 1.86947415786769e-05 NA NA NA hsa-miR-505-3p PDPK1 0.912823669571645 4.0549774967148e-13 -0.374841923318686 0.000672007355166274 mirMAP -0.201857415938712 5.57828239099272e-08 NA NA NA hsa-miR-542-3p PDPK1 0.643308814904977 8.81635403230104e-07 -0.374841923318686 0.000672007355166274 mirMAP -0.12781199559745 0.000462839050750517 NA NA NA hsa-miR-589-3p PDPK1 1.59559692667315 6.2886410639161e-15 -0.374841923318686 0.000672007355166274 mirMAP -0.128382873058573 5.41604824914142e-08 NA NA NA hsa-miR-590-5p PDPK1 0.763025362395968 3.65305892505623e-09 -0.374841923318686 0.000672007355166274 miRanda -0.162196982236768 9.45496024959358e-06 NA NA NA hsa-miR-708-3p PDPK1 1.32647174389322 4.87465491977979e-16 -0.374841923318686 0.000672007355166274 miRNATAP -0.14419428661467 3.79731361528411e-07 NA NA NA hsa-miR-93-3p PDPK1 1.69225547123293 1.50964095575087e-25 -0.374841923318686 0.000672007355166274 miRNATAP -0.114935719417259 4.60395655478685e-05 NA NA NA hsa-miR-93-5p PDPK1 1.61042951896619 5.1280369606967e-24 -0.374841923318686 0.000672007355166274 mirMAP -0.193660133494057 8.64542566364151e-12 NA NA NA hsa-miR-326 PGF -0.425943992128769 0.0415010315530797 1.7894778619937 1.67156328544061e-17 mirMAP -0.157120759961536 0.000531643956578871 NA NA NA hsa-miR-335-5p PGF -1.17227779671552 1.49282618530733e-10 1.7894778619937 1.67156328544061e-17 miRNATAP -0.285425943985743 1.33410478539352e-08 NA NA NA hsa-miR-34a-5p PGF -0.117372471043915 0.364001947180738 1.7894778619937 1.67156328544061e-17 miRNATAP -0.207393986339531 0.00483382962070574 NA NA NA hsa-miR-146b-5p PIK3CA 0.917975986853978 3.33749259316025e-09 0.474083948253385 0.000138354293457267 mirMAP -0.148623698754488 1.59224953432472e-05 NA NA NA hsa-miR-17-5p PIK3CA 1.41924888736771 2.75805544953758e-18 0.474083948253385 0.000138354293457267 miRNAWalker2_validate -0.121128691188414 0.000174670602072176 NA NA NA hsa-miR-186-5p PIK3CA 0.353452958261612 0.000145058448579496 0.474083948253385 0.000138354293457267 mirMAP -0.297473635549502 3.47602075640407e-07 NA NA NA hsa-miR-29b-1-5p PIK3CA 1.39669186711325 4.36960953138935e-11 0.474083948253385 0.000138354293457267 mirMAP -0.137606426566373 3.59722935161776e-08 NA NA NA hsa-miR-320a PIK3CA 0.801356001806321 4.91397101474502e-09 0.474083948253385 0.000138354293457267 miRanda -0.175899873415021 6.70887782534591e-06 NA NA NA hsa-miR-339-5p PIK3CA 1.07771430326938 2.45772601859307e-09 0.474083948253385 0.000138354293457267 miRanda -0.140087795917754 2.01352800438963e-06 NA NA NA hsa-miR-374b-5p PIK3CA -0.288413933608091 0.0041474558664058 0.474083948253385 0.000138354293457267 mirMAP -0.251699909641235 3.33151190183606e-06 NA NA NA hsa-miR-501-5p PIK3CA 1.02806906860218 1.63456814370548e-09 0.474083948253385 0.000138354293457267 mirMAP -0.119863788285527 0.00016396438241956 NA NA NA hsa-miR-576-5p PIK3CA 0.940432050128373 6.90227595663302e-12 0.474083948253385 0.000138354293457267 PITA -0.211172584428942 4.54724446596707e-08 NA NA NA hsa-miR-582-3p PIK3CA -0.248056267546012 0.143798829508405 0.474083948253385 0.000138354293457267 miRNATAP -0.112384075179319 0.000457171976884077 NA NA NA hsa-miR-590-3p PIK3CA 0.221436901462551 0.0965904764063157 0.474083948253385 0.000138354293457267 miRanda;mirMAP -0.123785866799948 0.00253231685417896 NA NA NA hsa-miR-590-5p PIK3CA 0.763025362395968 3.65305892505623e-09 0.474083948253385 0.000138354293457267 miRanda -0.137459565446424 0.000946581823458912 NA NA NA hsa-miR-130a-3p PIK3CB 0.67051191119964 4.89747518735144e-06 -0.0830016803916331 0.377605728994098 miRNATAP -0.116910694940516 2.17993945184649e-05 NA NA NA hsa-miR-455-5p PIK3CB 1.408595672323 5.52039116456697e-22 -0.0830016803916331 0.377605728994098 miRNATAP -0.112305249746916 2.65965267643942e-05 NA NA NA hsa-miR-1468-5p PIK3CD -1.11814152104975 9.8203170781489e-10 1.09936669850841 6.53933580961931e-14 MirTarget -0.190058878065479 5.39186071979921e-08 NA NA NA hsa-miR-199a-5p PIK3CD -0.364835768178638 0.0435119211101981 1.09936669850841 6.53933580961931e-14 MirTarget;PITA;miRanda;miRNATAP -0.10392905863127 0.00413232021656056 NA NA NA hsa-miR-199b-5p PIK3CD -1.08432682485992 7.68241801134089e-10 1.09936669850841 6.53933580961931e-14 MirTarget;PITA;miRanda;miRNATAP -0.174865940346935 1.46520648745166e-06 NA NA NA hsa-miR-29c-3p PIK3CD -2.08166260448948 8.3238369390898e-24 1.09936669850841 6.53933580961931e-14 mirMAP -0.123728555182124 3.91761687692399e-05 NA NA NA hsa-miR-30a-5p PIK3CD -1.79779915425811 1.93360169837799e-26 1.09936669850841 6.53933580961931e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.215181764255274 3.32715363881856e-09 23486085 miR 30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma; A luciferase reporter assay was performed to determine target association between miR-30a and phosphoinositide 3-kinase catalytic subunit delta PIK3CD miR-30a was significantly downregulated in highly metastatic CRC cell lines and metastatic tissues; Further studies revealed that PIK3CD is a direct target of miR-30a as miR-30a bounds directly to the 3'-UTR of PIK3CD subsequently reducing its expression; Similar to the restoring miR-30a expression PIK3CD downregulation inhibited cell migration and invasion whereas PIK3CD overexpression rescued the suppressive effect of miR-30a; Moreover significant downregulation of miR-30a in metastatic CRC tissues was found to be inversely correlated with PIK3CD expression; Mechanistic studies revealed that miR-30a down-regulated the expression of key components of the Akt/mTOR pathway whereas PIK3CD overexpression reversed this negative effect cell migration colorectal cancer hsa-miR-30b-3p PIK3CD -0.338530747940815 0.0223424741180399 1.09936669850841 6.53933580961931e-14 MirTarget -0.212653512510377 1.36776424072036e-06 NA NA NA hsa-miR-30b-5p PIK3CD -0.400238605368173 0.00346540992719245 1.09936669850841 6.53933580961931e-14 MirTarget -0.248889126985861 1.5426059915817e-07 NA NA NA hsa-miR-30d-5p PIK3CD -0.38399848121878 0.000171129616944749 1.09936669850841 6.53933580961931e-14 MirTarget;miRNATAP -0.328266173808776 2.63776877258142e-07 NA NA NA hsa-miR-30e-5p PIK3CD -1.02114836019762 6.81961221797866e-17 1.09936669850841 6.53933580961931e-14 MirTarget -0.209324939899388 5.5934958220938e-05 NA NA NA hsa-miR-126-3p PIK3CG 0.0487843863772834 0.730130847436008 0.00752271010659966 0.976960758681749 miRTarBase -0.269414114814437 0.000806379873030215 NA NA NA hsa-miR-26b-5p PIK3CG -0.254478038884324 0.0285227763044636 0.00752271010659966 0.976960758681749 miRNAWalker2_validate -0.345718989912845 0.00041292580999725 NA NA NA hsa-miR-335-3p PIK3CG 0.336785882180547 0.0542446207938138 0.00752271010659966 0.976960758681749 mirMAP -0.20863783184887 0.00127495716846541 NA NA NA hsa-miR-3607-3p PIK3CG 1.01377165357363 9.13355519701165e-05 0.00752271010659966 0.976960758681749 mirMAP -0.153979618634459 0.000387199003031277 NA NA NA hsa-miR-103a-3p PIK3R1 0.556219385347418 1.55815736455067e-09 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.399035342845615 3.61390305129075e-07 NA NA NA hsa-miR-1301-3p PIK3R1 2.13677668481885 6.11093268540831e-44 -1.21900359295309 1.01203266762174e-13 MirTarget -0.223004793710498 2.5912949051374e-07 NA NA NA hsa-miR-15a-5p PIK3R1 0.783550182002274 2.60699595655907e-11 -1.21900359295309 1.01203266762174e-13 MirTarget -0.385662977903284 1.7816116353762e-10 NA NA NA hsa-miR-15b-5p PIK3R1 0.85315666454713 3.79816274836297e-12 -1.21900359295309 1.01203266762174e-13 MirTarget -0.228618884263194 9.01523017331239e-05 NA NA NA hsa-miR-16-2-3p PIK3R1 1.1567130855258 1.01867256952189e-14 -1.21900359295309 1.01203266762174e-13 MirTarget -0.316425483424084 1.52783996282521e-11 NA NA NA hsa-miR-17-5p PIK3R1 1.41924888736771 2.75805544953758e-18 -1.21900359295309 1.01203266762174e-13 MirTarget;TargetScan;miRNATAP -0.463182517340129 2.13936557580788e-29 NA NA NA hsa-miR-182-5p PIK3R1 1.15060905311096 6.25565852529946e-10 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.244940881967473 1.25505363832818e-10 NA NA NA hsa-miR-185-5p PIK3R1 0.675225177054909 1.84953949190805e-13 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.284475955115523 0.000292942961891748 NA NA NA hsa-miR-186-5p PIK3R1 0.353452958261612 0.000145058448579496 -1.21900359295309 1.01203266762174e-13 mirMAP -0.319700116089251 4.98623038012755e-05 NA NA NA hsa-miR-188-5p PIK3R1 0.559328953885106 0.000430338888594543 -1.21900359295309 1.01203266762174e-13 MirTarget -0.160342440576419 0.000495444736297818 NA NA NA hsa-miR-200b-3p PIK3R1 0.0717138787925347 0.682858087587209 -1.21900359295309 1.01203266762174e-13 mirMAP -0.132316541375546 0.00152319590606084 NA NA NA hsa-miR-200c-3p PIK3R1 0.630251054099546 0.000131975031451555 -1.21900359295309 1.01203266762174e-13 mirMAP -0.165950070298812 0.000166005249225027 NA NA NA hsa-miR-20a-5p PIK3R1 1.1531986665452 1.02385132917958e-11 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.414035689070749 1.37700726304578e-24 NA NA NA hsa-miR-21-5p PIK3R1 1.62465922021121 3.44191300985109e-58 -1.21900359295309 1.01203266762174e-13 miRNAWalker2_validate;MirTarget;miRNATAP -0.347959293536401 6.14239978504788e-08 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 0.706731861922839 3.44318705980007e-07 -1.21900359295309 1.01203266762174e-13 mirMAP -0.186341013334501 0.000362689778770643 NA NA NA hsa-miR-222-3p PIK3R1 1.08197052578759 2.32604040301699e-14 -1.21900359295309 1.01203266762174e-13 MirTarget -0.324361920211689 6.16230355082933e-11 NA NA NA hsa-miR-224-3p PIK3R1 0.502645536188015 0.0081142387260641 -1.21900359295309 1.01203266762174e-13 mirMAP -0.120566945623901 0.00184832047796862 NA NA NA hsa-miR-29b-3p PIK3R1 -0.110721443686039 0.511264554091106 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.121645516169564 0.00518596779631768 NA NA NA hsa-miR-320a PIK3R1 0.801356001806321 4.91397101474502e-09 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.225199809648846 1.82460995490226e-05 NA NA NA hsa-miR-320b PIK3R1 1.23473838180754 3.04337566045537e-14 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.134920857869101 0.00211752860446172 NA NA NA hsa-miR-324-3p PIK3R1 0.867391246413545 3.63808540490361e-10 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRNATAP -0.177541714088148 0.000648957139596168 NA NA NA hsa-miR-424-5p PIK3R1 1.48125289532143 9.10372985713165e-19 -1.21900359295309 1.01203266762174e-13 MirTarget -0.194732317900543 3.45343462326547e-06 NA NA NA hsa-miR-429 PIK3R1 0.559451508722375 0.00563641638673083 -1.21900359295309 1.01203266762174e-13 mirMAP;miRNATAP -0.216477715044302 1.22729945836841e-09 NA NA NA hsa-miR-450b-5p PIK3R1 1.25529820885833 1.18847120528666e-15 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.182288230735551 5.59609717066614e-05 NA NA NA hsa-miR-455-3p PIK3R1 2.68574446868387 4.28975903022818e-42 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRNATAP -0.231037194203872 4.67534308068801e-12 NA NA NA hsa-miR-584-5p PIK3R1 0.458655788667031 0.0421764547676754 -1.21900359295309 1.01203266762174e-13 mirMAP -0.158511510137748 8.00515680759562e-07 NA NA NA hsa-miR-589-3p PIK3R1 1.59559692667315 6.2886410639161e-15 -1.21900359295309 1.01203266762174e-13 mirMAP -0.276889190811914 4.76785574986701e-15 NA NA NA hsa-miR-590-3p PIK3R1 0.221436901462551 0.0965904764063157 -1.21900359295309 1.01203266762174e-13 miRanda;mirMAP -0.158050349961081 0.00414021352655968 NA NA NA hsa-miR-590-5p PIK3R1 0.763025362395968 3.65305892505623e-09 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRanda;miRNATAP -0.424270969807281 7.70480985025408e-15 NA NA NA hsa-miR-629-3p PIK3R1 1.43262037314105 2.37092217984413e-19 -1.21900359295309 1.01203266762174e-13 MirTarget -0.192452582760208 1.31715256298262e-05 NA NA NA hsa-miR-93-5p PIK3R1 1.61042951896619 5.1280369606967e-24 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.348791344759735 3.1302460531533e-16 NA NA NA hsa-miR-96-5p PIK3R1 1.42326703011157 4.39736150032373e-14 -1.21900359295309 1.01203266762174e-13 TargetScan;miRNATAP -0.310953673912161 2.47412618125618e-17 NA NA NA hsa-miR-18a-3p PIK3R3 1.82583720936229 7.51297960972179e-19 -0.129019532966171 0.451055967559973 miRNAWalker2_validate -0.103240638013552 0.00398585116122596 NA NA NA hsa-miR-19a-3p PIK3R3 1.35800152353624 2.80940447111944e-12 -0.129019532966171 0.451055967559973 MirTarget;miRNATAP -0.153374017381767 4.01568767526052e-05 NA NA NA hsa-miR-19b-3p PIK3R3 0.538732279378089 0.000622008277870679 -0.129019532966171 0.451055967559973 MirTarget;miRNATAP -0.12996294371586 0.00591308278368021 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.39669186711325 4.36960953138935e-11 -0.129019532966171 0.451055967559973 mirMAP -0.137442753028623 6.48468495867568e-05 NA NA NA hsa-miR-365a-3p PIK3R3 0.446833934952926 0.00233857759218299 -0.129019532966171 0.451055967559973 MirTarget -0.431569400997508 1.46400297130903e-18 NA NA NA hsa-miR-369-3p PIK3R3 -1.2344419076994 2.66882944171146e-10 -0.129019532966171 0.451055967559973 PITA -0.105890967034452 0.00482950119317686 NA NA NA hsa-miR-589-3p PIK3R3 1.59559692667315 6.2886410639161e-15 -0.129019532966171 0.451055967559973 mirMAP -0.138465461387875 0.000168219132587265 NA NA NA hsa-miR-182-5p PIK3R5 1.15060905311096 6.25565852529946e-10 0.15902332125267 0.38685549407615 MirTarget -0.236115638976413 1.63099014479463e-08 NA NA NA hsa-miR-18a-3p PIK3R5 1.82583720936229 7.51297960972179e-19 0.15902332125267 0.38685549407615 MirTarget -0.160296162742907 2.89078394864452e-05 NA NA NA hsa-miR-944 PIK3R5 1.47323925060177 2.61626403984929e-13 0.15902332125267 0.38685549407615 mirMAP -0.211607874388069 3.42384043348289e-08 NA NA NA hsa-miR-15a-5p PRKAA1 0.783550182002274 2.60699595655907e-11 -0.0448262168852596 0.617998429372707 MirTarget -0.156905436702793 1.37446799039965e-06 NA NA NA hsa-miR-19b-3p PRKAA1 0.538732279378089 0.000622008277870679 -0.0448262168852596 0.617998429372707 miRNAWalker2_validate;miRTarBase;miRNATAP -0.109545304680261 8.30801069525184e-06 NA NA NA hsa-miR-29b-3p PRKAA1 -0.110721443686039 0.511264554091106 -0.0448262168852596 0.617998429372707 miRNAWalker2_validate -0.100562103702332 1.31191826414042e-05 NA NA NA hsa-miR-374b-5p PRKAA1 -0.288413933608091 0.0041474558664058 -0.0448262168852596 0.617998429372707 mirMAP -0.103883367130632 0.00781775652081419 NA NA NA hsa-miR-454-3p PRKAA1 1.54137391927201 4.15861570449376e-20 -0.0448262168852596 0.617998429372707 MirTarget;miRNATAP -0.10247726605432 4.12003327060681e-06 NA NA NA hsa-let-7a-3p PRKAA2 0.0966652362351867 0.423761916840503 -3.3470784437381 8.23487674630099e-16 mirMAP -0.611119580423561 7.98502585532926e-05 NA NA NA hsa-let-7f-1-3p PRKAA2 0.700374242293247 8.65000484720084e-08 -3.3470784437381 8.23487674630099e-16 mirMAP -0.487259572982436 0.000560841653796392 NA NA NA hsa-miR-103a-2-5p PRKAA2 1.37988337975616 6.74852943995612e-08 -3.3470784437381 8.23487674630099e-16 mirMAP -0.539822929919598 2.40195295605549e-12 NA NA NA hsa-miR-130a-3p PRKAA2 0.67051191119964 4.89747518735144e-06 -3.3470784437381 8.23487674630099e-16 MirTarget -0.638055466500704 3.58629879630716e-07 NA NA NA hsa-miR-141-3p PRKAA2 0.730011517758706 0.000120338355004032 -3.3470784437381 8.23487674630099e-16 mirMAP -0.416178697461822 1.89540759330245e-05 NA NA NA hsa-miR-146b-5p PRKAA2 0.917975986853978 3.33749259316025e-09 -3.3470784437381 8.23487674630099e-16 MirTarget -0.519924766866759 1.05607879455206e-05 NA NA NA hsa-miR-15b-3p PRKAA2 1.05020782493504 6.38723677324836e-14 -3.3470784437381 8.23487674630099e-16 mirMAP -0.437017461939157 0.00078725458567671 NA NA NA hsa-miR-16-2-3p PRKAA2 1.1567130855258 1.01867256952189e-14 -3.3470784437381 8.23487674630099e-16 mirMAP -0.575199625135728 1.98337798840478e-06 NA NA NA hsa-miR-17-5p PRKAA2 1.41924888736771 2.75805544953758e-18 -3.3470784437381 8.23487674630099e-16 mirMAP -0.864308747211701 1.26060278442975e-15 NA NA NA hsa-miR-181a-5p PRKAA2 0.819060835827404 1.38616688310277e-13 -3.3470784437381 8.23487674630099e-16 mirMAP -0.742825872159103 6.4444540415514e-06 NA NA NA hsa-miR-181b-5p PRKAA2 0.974255518824355 2.64876280203475e-16 -3.3470784437381 8.23487674630099e-16 mirMAP -0.837014766578103 3.22472133301961e-08 NA NA NA hsa-miR-182-5p PRKAA2 1.15060905311096 6.25565852529946e-10 -3.3470784437381 8.23487674630099e-16 miRNAWalker2_validate;MirTarget;mirMAP -0.362449071929737 0.000230854210912145 NA NA NA hsa-miR-186-5p PRKAA2 0.353452958261612 0.000145058448579496 -3.3470784437381 8.23487674630099e-16 MirTarget -0.752276329421756 0.000185884264927097 NA NA NA hsa-miR-19a-3p PRKAA2 1.35800152353624 2.80940447111944e-12 -3.3470784437381 8.23487674630099e-16 mirMAP -0.73118499624708 1.35680433441337e-15 NA NA NA hsa-miR-19b-3p PRKAA2 0.538732279378089 0.000622008277870679 -3.3470784437381 8.23487674630099e-16 mirMAP -0.669616403260058 1.01112552995543e-08 NA NA NA hsa-miR-200a-3p PRKAA2 0.607140814457753 0.00289840524858752 -3.3470784437381 8.23487674630099e-16 mirMAP -0.379939777377135 2.8984541995274e-05 NA NA NA hsa-miR-200c-3p PRKAA2 0.630251054099546 0.000131975031451555 -3.3470784437381 8.23487674630099e-16 MirTarget -0.295905651999808 0.00870783514718382 NA NA NA hsa-miR-203a-3p PRKAA2 0.0441399794719697 0.880456392176704 -3.3470784437381 8.23487674630099e-16 MirTarget -0.40992158532276 5.48305444296988e-11 NA NA NA hsa-miR-20a-5p PRKAA2 1.1531986665452 1.02385132917958e-11 -3.3470784437381 8.23487674630099e-16 mirMAP -0.741150862622723 2.59756622536852e-12 NA NA NA hsa-miR-21-3p PRKAA2 1.25126438776674 2.4124216716282e-17 -3.3470784437381 8.23487674630099e-16 mirMAP -1.00906200551318 2.23214859170938e-17 NA NA NA hsa-miR-22-5p PRKAA2 0.706731861922839 3.44318705980007e-07 -3.3470784437381 8.23487674630099e-16 mirMAP -0.392957976851608 0.0032577569514928 NA NA NA hsa-miR-23a-3p PRKAA2 0.348231698801568 6.4911858506572e-05 -3.3470784437381 8.23487674630099e-16 mirMAP -0.702122647808233 0.00111605781813569 NA NA NA hsa-miR-27b-5p PRKAA2 0.580870079022649 0.000181529223377382 -3.3470784437381 8.23487674630099e-16 MirTarget;miRNATAP -0.436557866300137 0.000261655643298835 NA NA NA hsa-miR-301a-3p PRKAA2 2.14132004241926 4.46255413526808e-25 -3.3470784437381 8.23487674630099e-16 MirTarget -0.566247147035862 1.89997128006839e-11 NA NA NA hsa-miR-31-5p PRKAA2 2.79079137807505 1.72181058015659e-13 -3.3470784437381 8.23487674630099e-16 MirTarget -0.472854026119331 2.44026859889055e-24 NA NA NA hsa-miR-331-3p PRKAA2 0.906385914819361 4.27653809739414e-11 -3.3470784437381 8.23487674630099e-16 MirTarget -0.35963781665794 0.00714942766572411 NA NA NA hsa-miR-342-3p PRKAA2 0.99756868977753 9.28499866272332e-10 -3.3470784437381 8.23487674630099e-16 PITA -0.472020333235437 2.63832918178842e-05 NA NA NA hsa-miR-429 PRKAA2 0.559451508722375 0.00563641638673083 -3.3470784437381 8.23487674630099e-16 MirTarget;miRNATAP -0.238354734769169 0.00972265295199331 NA NA NA hsa-miR-452-3p PRKAA2 1.09618110917892 2.21867884261816e-07 -3.3470784437381 8.23487674630099e-16 mirMAP -0.376036025718865 1.44865050274686e-05 NA NA NA hsa-miR-454-3p PRKAA2 1.54137391927201 4.15861570449376e-20 -3.3470784437381 8.23487674630099e-16 MirTarget -0.769000443316249 2.22740451533364e-13 NA NA NA hsa-miR-500a-5p PRKAA2 0.675401699376111 8.24389004707854e-05 -3.3470784437381 8.23487674630099e-16 mirMAP -0.370089325264102 0.000616140983813196 NA NA NA hsa-miR-576-5p PRKAA2 0.940432050128373 6.90227595663302e-12 -3.3470784437381 8.23487674630099e-16 mirMAP -1.06364860334457 2.94950846997241e-16 NA NA NA hsa-miR-589-5p PRKAA2 0.807877250867909 4.12262850391353e-14 -3.3470784437381 8.23487674630099e-16 MirTarget -0.773044469338115 5.75330157138291e-06 NA NA NA hsa-miR-7-1-3p PRKAA2 1.13646121619622 1.49823237535933e-14 -3.3470784437381 8.23487674630099e-16 MirTarget;mirMAP -0.615777535046871 4.71256321695788e-07 NA NA NA hsa-miR-93-5p PRKAA2 1.61042951896619 5.1280369606967e-24 -3.3470784437381 8.23487674630099e-16 mirMAP -0.472036673630309 2.28625034490348e-05 NA NA NA hsa-miR-944 PRKAA2 1.47323925060177 2.61626403984929e-13 -3.3470784437381 8.23487674630099e-16 mirMAP -0.513120238556238 9.40471370250645e-09 NA NA NA hsa-miR-96-5p PRKAA2 1.42326703011157 4.39736150032373e-14 -3.3470784437381 8.23487674630099e-16 TargetScan -0.418320078480582 1.32057548932296e-05 NA NA NA hsa-miR-744-5p RHEB 0.436098372735845 0.000850400989351181 0.226319699277753 0.00269577315352952 miRNAWalker2_validate -0.100439624808417 5.93644077169242e-05 NA NA NA hsa-miR-15a-5p RICTOR 0.783550182002274 2.60699595655907e-11 0.207301064505204 0.0467422902871133 MirTarget;miRNATAP -0.118257346728735 0.00187512364349054 NA NA NA hsa-miR-19b-3p RICTOR 0.538732279378089 0.000622008277870679 0.207301064505204 0.0467422902871133 MirTarget;miRNATAP -0.137093538914424 1.55423011933289e-06 NA NA NA hsa-miR-30d-3p RICTOR -0.577371911152798 2.02950840095287e-06 0.207301064505204 0.0467422902871133 MirTarget;miRNATAP -0.10468968185952 0.00494512351137742 NA NA NA hsa-miR-500a-5p RICTOR 0.675401699376111 8.24389004707854e-05 0.207301064505204 0.0467422902871133 MirTarget;mirMAP -0.115313569549417 1.04926165307119e-05 NA NA NA hsa-miR-660-5p RICTOR -0.202705992887645 0.101093376073573 0.207301064505204 0.0467422902871133 MirTarget -0.232664437765899 1.46723173809909e-10 NA NA NA hsa-miR-744-5p RPS6 0.436098372735845 0.000850400989351181 -0.70252402039163 3.07494562257944e-08 miRNAWalker2_validate -0.177206027999288 3.22590949867249e-05 NA NA NA hsa-miR-125b-5p RPS6KA1 -0.993460109818276 5.07736727659894e-12 0.596749611096817 2.29662308108149e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.153562725015249 1.46644174198298e-06 NA NA NA hsa-miR-28-5p RPS6KA1 -0.026996999089909 0.733047113251652 0.596749611096817 2.29662308108149e-08 miRanda -0.220789370796156 0.0002605117684115 NA NA NA hsa-let-7g-3p RPS6KA2 0.637019243992294 0.000204623048574065 -0.818335052704694 1.49802394463738e-07 MirTarget -0.159282346530698 6.02012922742781e-05 NA NA NA hsa-miR-1271-5p RPS6KA2 0.564681884899804 0.000425257395055278 -0.818335052704694 1.49802394463738e-07 mirMAP -0.137646479459463 0.00127222769297982 NA NA NA hsa-miR-130b-5p RPS6KA2 1.77265255049999 1.43627774829684e-29 -0.818335052704694 1.49802394463738e-07 mirMAP -0.174974710379219 2.10165541609256e-05 NA NA NA hsa-miR-17-5p RPS6KA2 1.41924888736771 2.75805544953758e-18 -0.818335052704694 1.49802394463738e-07 TargetScan -0.377465112992773 6.31636695590034e-22 NA NA NA hsa-miR-193a-3p RPS6KA2 0.22120710726779 0.111827069464729 -0.818335052704694 1.49802394463738e-07 mirMAP -0.19256032016045 9.5536814573829e-05 NA NA NA hsa-miR-193b-3p RPS6KA2 1.72788400801602 3.0722151264559e-21 -0.818335052704694 1.49802394463738e-07 mirMAP -0.202082067184624 1.50481084371598e-08 NA NA NA hsa-miR-19a-3p RPS6KA2 1.35800152353624 2.80940447111944e-12 -0.818335052704694 1.49802394463738e-07 MirTarget -0.311634984678888 7.92960241402116e-21 NA NA NA hsa-miR-19b-3p RPS6KA2 0.538732279378089 0.000622008277870679 -0.818335052704694 1.49802394463738e-07 MirTarget -0.381223777198004 1.12744252755145e-19 NA NA NA hsa-miR-200b-3p RPS6KA2 0.0717138787925347 0.682858087587209 -0.818335052704694 1.49802394463738e-07 TargetScan -0.255615314712537 3.27827961462796e-11 NA NA NA hsa-miR-200c-3p RPS6KA2 0.630251054099546 0.000131975031451555 -0.818335052704694 1.49802394463738e-07 miRNATAP -0.247316725486219 1.49039287285506e-09 NA NA NA hsa-miR-21-3p RPS6KA2 1.25126438776674 2.4124216716282e-17 -0.818335052704694 1.49802394463738e-07 MirTarget -0.297454561784315 1.93095248173415e-11 NA NA NA hsa-miR-26b-5p RPS6KA2 -0.254478038884324 0.0285227763044636 -0.818335052704694 1.49802394463738e-07 miRNATAP -0.159613659119711 0.00723064319634244 NA NA NA hsa-miR-30b-5p RPS6KA2 -0.400238605368173 0.00346540992719245 -0.818335052704694 1.49802394463738e-07 MirTarget -0.203997361568164 4.47040554580069e-05 NA NA NA hsa-miR-30c-5p RPS6KA2 0.021222006155897 0.886366656528128 -0.818335052704694 1.49802394463738e-07 MirTarget;miRNATAP -0.177722948751106 0.000122221635439775 NA NA NA hsa-miR-429 RPS6KA2 0.559451508722375 0.00563641638673083 -0.818335052704694 1.49802394463738e-07 miRanda;miRNATAP -0.242130518638547 2.87557792828138e-13 NA NA NA hsa-miR-532-3p RPS6KA2 0.80240056676907 1.08989551712617e-09 -0.818335052704694 1.49802394463738e-07 MirTarget;mirMAP -0.184979835948607 0.000319663071786608 NA NA NA hsa-miR-9-5p RPS6KA2 1.65694862043766 2.08325802567323e-05 -0.818335052704694 1.49802394463738e-07 miRNATAP -0.106479212620095 6.19574002522226e-10 NA NA NA hsa-miR-93-3p RPS6KA2 1.69225547123293 1.50964095575087e-25 -0.818335052704694 1.49802394463738e-07 MirTarget -0.279898533867669 1.54537186298373e-12 NA NA NA hsa-miR-103a-3p RPS6KA3 0.556219385347418 1.55815736455067e-09 -0.288537450262601 0.0109275717451252 MirTarget -0.174681659311864 0.00105720081449375 NA NA NA hsa-miR-15a-5p RPS6KA3 0.783550182002274 2.60699595655907e-11 -0.288537450262601 0.0109275717451252 MirTarget;miRNATAP -0.254959516181223 4.37501425044547e-10 NA NA NA hsa-miR-17-5p RPS6KA3 1.41924888736771 2.75805544953758e-18 -0.288537450262601 0.0109275717451252 TargetScan;miRNATAP -0.128564368794749 1.08092048466133e-05 NA NA NA hsa-miR-181a-5p RPS6KA3 0.819060835827404 1.38616688310277e-13 -0.288537450262601 0.0109275717451252 MirTarget;mirMAP;miRNATAP -0.20832245711034 1.7111658647179e-06 NA NA NA hsa-miR-181b-5p RPS6KA3 0.974255518824355 2.64876280203475e-16 -0.288537450262601 0.0109275717451252 MirTarget;mirMAP;miRNATAP -0.233898069631251 5.03412183239972e-09 NA NA NA hsa-miR-20a-5p RPS6KA3 1.1531986665452 1.02385132917958e-11 -0.288537450262601 0.0109275717451252 miRNATAP -0.151380903515229 8.92443397551179e-08 NA NA NA hsa-miR-21-5p RPS6KA3 1.62465922021121 3.44191300985109e-58 -0.288537450262601 0.0109275717451252 miRNAWalker2_validate;mirMAP;miRNATAP -0.166170297916274 0.000143365312097424 NA NA NA hsa-miR-29b-1-5p RPS6KA3 1.39669186711325 4.36960953138935e-11 -0.288537450262601 0.0109275717451252 mirMAP -0.118049339934378 1.99502792388805e-07 NA NA NA hsa-miR-320a RPS6KA3 0.801356001806321 4.91397101474502e-09 -0.288537450262601 0.0109275717451252 miRNAWalker2_validate;miRanda -0.128263583257447 0.000311858781988534 NA NA NA hsa-miR-503-5p RPS6KA3 2.85210590411715 1.27298190263569e-35 -0.288537450262601 0.0109275717451252 miRNAWalker2_validate -0.10546766258564 4.55743405132703e-07 NA NA NA hsa-miR-93-5p RPS6KA3 1.61042951896619 5.1280369606967e-24 -0.288537450262601 0.0109275717451252 miRNATAP -0.122472749889238 3.33750446715353e-05 NA NA NA hsa-miR-141-3p RPS6KA6 0.730011517758706 0.000120338355004032 -3.76847777386574 1.8223601760702e-19 MirTarget -0.366917777856374 0.000201799656432614 NA NA NA hsa-miR-15a-5p RPS6KA6 0.783550182002274 2.60699595655907e-11 -3.76847777386574 1.8223601760702e-19 MirTarget -1.12998133359345 3.32923849152607e-13 NA NA NA hsa-miR-15b-5p RPS6KA6 0.85315666454713 3.79816274836297e-12 -3.76847777386574 1.8223601760702e-19 MirTarget -0.628797262164557 2.9811400082452e-05 NA NA NA hsa-miR-16-5p RPS6KA6 0.521122945828175 1.40561786410572e-06 -3.76847777386574 1.8223601760702e-19 MirTarget -0.787839286203253 5.60843523438959e-06 NA NA NA hsa-miR-17-5p RPS6KA6 1.41924888736771 2.75805544953758e-18 -3.76847777386574 1.8223601760702e-19 TargetScan -0.686391408668744 5.66752618788398e-10 NA NA NA hsa-miR-19a-3p RPS6KA6 1.35800152353624 2.80940447111944e-12 -3.76847777386574 1.8223601760702e-19 MirTarget -0.668456836925976 7.33540361911542e-13 NA NA NA hsa-miR-19b-3p RPS6KA6 0.538732279378089 0.000622008277870679 -3.76847777386574 1.8223601760702e-19 MirTarget -0.556388192740529 2.90023177095393e-06 NA NA NA hsa-miR-205-3p RPS6KA6 1.2960640797621 5.80786479909147e-11 -3.76847777386574 1.8223601760702e-19 MirTarget -0.67542706887551 1.69917794966981e-13 NA NA NA hsa-miR-20a-3p RPS6KA6 1.34885093664027 2.07697464119202e-12 -3.76847777386574 1.8223601760702e-19 MirTarget -0.360252686697966 0.000176652501760457 NA NA NA hsa-miR-424-5p RPS6KA6 1.48125289532143 9.10372985713165e-19 -3.76847777386574 1.8223601760702e-19 MirTarget -0.670278572605216 4.41141758978883e-10 NA NA NA hsa-miR-589-3p RPS6KA6 1.59559692667315 6.2886410639161e-15 -3.76847777386574 1.8223601760702e-19 MirTarget -0.44654609483773 1.55318743944128e-06 NA NA NA hsa-miR-590-3p RPS6KA6 0.221436901462551 0.0965904764063157 -3.76847777386574 1.8223601760702e-19 MirTarget;miRanda;mirMAP;miRNATAP -0.540657690659165 0.000139044850681365 NA NA NA hsa-miR-181b-5p RPS6KB1 0.974255518824355 2.64876280203475e-16 -0.119108736560683 0.0926638906295523 MirTarget;miRNATAP -0.119633629536219 1.70396937286662e-06 NA NA NA hsa-miR-181d-5p RPS6KB1 0.367649966373544 0.00537300571455306 -0.119108736560683 0.0926638906295523 MirTarget -0.131213437312102 1.20102357516116e-08 NA NA NA hsa-miR-664a-3p RPS6KB1 -0.256108763664991 0.0513188660751664 -0.119108736560683 0.0926638906295523 MirTarget -0.124956709530079 7.38971405939269e-08 NA NA NA hsa-miR-331-3p RPS6KB2 0.906385914819361 4.27653809739414e-11 -0.178930142491454 0.154821414351084 miRNATAP -0.129866487266148 0.000903136770244418 NA NA NA hsa-miR-106b-5p ULK1 0.50378717276868 1.45412404526866e-05 0.623010168662856 1.04309272213136e-09 miRNATAP -0.11469524140753 0.00309013713807889 NA NA NA hsa-miR-142-5p ULK1 0.288897753038094 0.0900009317815725 0.623010168662856 1.04309272213136e-09 PITA;miRNATAP -0.156480219818059 2.2200473195194e-09 NA NA NA hsa-miR-16-5p ULK1 0.521122945828175 1.40561786410572e-06 0.623010168662856 1.04309272213136e-09 miRNAWalker2_validate -0.13732955386049 0.00097128198061965 NA NA NA hsa-miR-26a-5p ULK1 -1.09269574587169 1.24020612216319e-22 0.623010168662856 1.04309272213136e-09 miRNATAP -0.278807913410736 2.60882830923925e-13 NA NA NA hsa-miR-26b-5p ULK1 -0.254478038884324 0.0285227763044636 0.623010168662856 1.04309272213136e-09 miRNATAP -0.12773240230116 0.00105335088662205 NA NA NA hsa-miR-32-5p ULK1 -0.317310201890053 0.0102525324475293 0.623010168662856 1.04309272213136e-09 miRNATAP -0.159966981170053 1.13104799037771e-05 NA NA NA hsa-miR-330-3p ULK1 -0.0524949332825773 0.719856123539461 0.623010168662856 1.04309272213136e-09 mirMAP -0.116707131408861 0.000158348574812218 NA NA NA hsa-miR-335-5p ULK1 -1.17227779671552 1.49282618530733e-10 0.623010168662856 1.04309272213136e-09 miRNAWalker2_validate -0.108112676176819 7.19710136526651e-06 NA NA NA hsa-miR-338-5p ULK1 -1.71946558699173 2.62649071488641e-23 0.623010168662856 1.04309272213136e-09 PITA -0.13746085913999 2.62834380935148e-08 NA NA NA hsa-miR-423-5p ULK1 0.60141781325829 1.62940950644999e-07 0.623010168662856 1.04309272213136e-09 miRNAWalker2_validate -0.116689039473632 0.00282133022853479 NA NA NA hsa-let-7f-1-3p ULK2 0.700374242293247 8.65000484720084e-08 -0.201048776136343 0.0819725896540345 MirTarget -0.123371355474544 0.00119856095890059 NA NA NA hsa-miR-7-1-3p ULK2 1.13646121619622 1.49823237535933e-14 -0.201048776136343 0.0819725896540345 MirTarget;mirMAP -0.110898472660973 0.000825768946303951 NA NA NA hsa-miR-28-5p ULK3 -0.026996999089909 0.733047113251652 -0.865133143340819 2.09243578478706e-15 miRanda -0.288396077580352 3.83701754149806e-06 NA NA NA hsa-miR-330-5p ULK3 0.944693925383906 5.04972895657346e-13 -0.865133143340819 2.09243578478706e-15 miRanda -0.107991073138818 0.00316146221289252 NA NA NA hsa-miR-744-5p ULK3 0.436098372735845 0.000850400989351181 -0.865133143340819 2.09243578478706e-15 miRNAWalker2_validate -0.126206142646558 0.000709123862390992 NA NA NA hsa-miR-101-3p VEGFA -1.91263766544878 1.50270129259053e-39 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate -0.281477062331858 8.81075776241686e-11 NA NA NA hsa-miR-134-5p VEGFA -0.598302069876985 0.00124773585997939 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.114375387301794 0.00210306889630562 NA NA NA hsa-miR-140-5p VEGFA -0.412389003031485 0.000136051708543369 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.268410061738275 2.63838447575462e-05 26402430 MicroRNA 140 5p inhibits the progression of colorectal cancer by targeting VEGFA; The direct regulation of VEGFA by miR-140-5p was identified using luciferase reporter assay; Integrated analysis identified VEGFA as a direct and functional target gene of miR-140-5p; Silencing VEGFA by small interfering RNA siRNA resembled the phenotype resulting from ectopic miR-140-5p expression while overexpression of VEGFA attenuated the effect of miR-140-5p on CRC cells; Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA progression;tumorigenesis colorectal cancer hsa-miR-150-5p VEGFA -0.243749814009231 0.331546276920338 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase -0.1837154779422 1.13782348414927e-11 NA NA NA hsa-miR-195-5p VEGFA -1.8367376818177 6.9944883988895e-31 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.266371206927854 4.016968187035e-11 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199b-5p VEGFA -1.08432682485992 7.68241801134089e-10 0.873514320132464 2.52351953389146e-08 miRanda -0.107087744674295 0.00559641745284255 NA NA NA hsa-miR-29a-3p VEGFA -1.26881270980079 2.82496991513463e-22 0.873514320132464 2.52351953389146e-08 MirTarget -0.288406509783812 9.95429090012523e-09 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29c-3p VEGFA -2.08166260448948 8.3238369390898e-24 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;MirTarget -0.194088476141854 6.98364039221839e-10 NA NA NA hsa-miR-374a-5p VEGFA -0.621903385111545 6.61791773205282e-12 0.873514320132464 2.52351953389146e-08 MirTarget -0.350545644085801 3.16629895028707e-06 23679262 Our data demonstrated miR-374a to be differentially distributed in breast cancer; VEGF-A and VCAM-1 mRNA had coincident distribution and the distribution of teh respective proteins was uneven and opposite to that for the miR-374a breast cancer hsa-miR-378a-3p VEGFA -1.50453783521372 9.41694954361173e-17 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase -0.103722847977571 0.00515698881281656 NA NA NA hsa-miR-128-3p VEGFC -0.170677254601174 0.20412808476528 1.21496433527706 2.56999707057218e-05 miRNAWalker2_validate;MirTarget -0.344606861179054 0.000264644189549296 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-129-5p VEGFC -0.246329588499478 0.436451191224681 1.21496433527706 2.56999707057218e-05 miRanda -0.181674391970532 6.89957949062694e-06 NA NA NA hsa-miR-16-2-3p VEGFC 1.1567130855258 1.01867256952189e-14 1.21496433527706 2.56999707057218e-05 MirTarget -0.264631968748485 0.00136032612419468 NA NA NA hsa-miR-27b-3p VEGFC -0.732682718863563 2.26896143573324e-09 1.21496433527706 2.56999707057218e-05 MirTarget -1.03529262957351 2.14560495828989e-26 23593282 We identified vascular endothelial growth factor C VEGFC as a novel target gene of miR-27b and determined that miR-27b functioned as an inhibitor of tumor progression and angiogenesis through targeting VEGFC in CRC; In summary an anti-tumor role for miR-27b and its novel target VEGFC in vivo could lead to tumor necrosis and provide a rationale for developing miR-27b as a therapeutic agent progression colorectal cancer hsa-miR-374a-5p VEGFC -0.621903385111545 6.61791773205282e-12 1.21496433527706 2.56999707057218e-05 MirTarget -0.421266396238901 0.00236790056229042 NA NA NA