miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-10b-5p CTBP1 -0.89971464210447 1.18190532299934e-20 0.343157054749229 1.70497605764461e-10 miRNAWalker2_validate -0.169551641028977 5.50059572178262e-09 NA NA NA hsa-miR-142-3p DLL1 1.88928758773299 2.72985643829893e-22 0.615880401591949 2.38965687335383e-05 miRanda -0.115442945181291 0.00305911161985238 NA NA NA hsa-miR-146b-5p DLL1 1.40714170253819 2.9559871816487e-12 0.615880401591949 2.38965687335383e-05 miRanda -0.14320681923765 0.000219358318949595 NA NA NA hsa-miR-149-5p DLL1 -1.95790336710741 8.46371715052367e-27 0.615880401591949 2.38965687335383e-05 miRNATAP -0.135097708577687 0.000960027998156531 NA NA NA hsa-miR-199b-5p DLL1 -2.39483476763681 1.04659509514884e-17 0.615880401591949 2.38965687335383e-05 miRanda -0.107489659753148 0.000127479502848677 NA NA NA hsa-miR-335-5p DLL1 -2.09515619961552 1.03765771499548e-25 0.615880401591949 2.38965687335383e-05 miRNAWalker2_validate -0.194374712462143 1.99233885848161e-07 NA NA NA hsa-miR-362-5p DLL1 -2.72767654824605 1.34821749679113e-49 0.615880401591949 2.38965687335383e-05 PITA;TargetScan;miRNATAP -0.134905608682787 0.000332216747185617 NA NA NA hsa-miR-493-5p DLL1 -1.03936667688502 3.71842205277243e-08 0.615880401591949 2.38965687335383e-05 miRNATAP -0.121805918163616 0.00517832759651237 NA NA NA hsa-miR-125b-5p DLL4 -0.825456421494266 2.13029877878434e-15 2.29532698835556 5.25833113086408e-40 miRNATAP -0.579153605180703 3.66688270383087e-09 NA NA NA hsa-miR-199a-3p DLL4 -1.61607426368083 1.97964980193147e-26 2.29532698835556 5.25833113086408e-40 PITA -0.388591078852663 1.6510833670885e-09 NA NA NA hsa-miR-199b-3p DLL4 -1.61804389801139 1.97668652730486e-26 2.29532698835556 5.25833113086408e-40 PITA -0.388346456699147 1.61329680989575e-09 NA NA NA hsa-miR-29a-5p DLL4 -0.519003718107105 1.03351148282116e-06 2.29532698835556 5.25833113086408e-40 miRNATAP -0.631473592420541 1.4708827646635e-10 NA NA NA hsa-miR-30a-5p DLL4 -0.778411951775343 2.73322451127932e-16 2.29532698835556 5.25833113086408e-40 miRNATAP -0.486378724620209 7.33151780030063e-06 NA NA NA hsa-miR-30c-5p DLL4 -1.08783070774238 2.02505402525786e-24 2.29532698835556 5.25833113086408e-40 miRNATAP -0.588844634161174 1.90746655329948e-10 NA NA NA hsa-miR-429 DLL4 -2.16569233119434 2.66862243626443e-37 2.29532698835556 5.25833113086408e-40 miRanda -0.466323782630996 6.61832296336517e-18 NA NA NA hsa-miR-194-3p DTX1 -0.0573594560647068 0.802137112420482 -2.55278367888008 5.94172985782251e-40 miRNATAP -0.255204882126683 1.38131687418579e-06 NA NA NA hsa-miR-331-3p DTX1 0.431607034018882 6.83022920590941e-05 -2.55278367888008 5.94172985782251e-40 PITA;miRNATAP -0.410833361813752 0.000197698914766506 NA NA NA hsa-miR-484 DTX1 0.571987778099603 9.67278224458421e-10 -2.55278367888008 5.94172985782251e-40 miRNATAP -0.573685569693218 4.83461915132524e-06 NA NA NA hsa-let-7e-5p DTX2 -0.727009689927955 1.30690859412163e-11 1.26267931625876 4.06724284118122e-40 miRNATAP -0.418029607727154 5.62781662393051e-16 NA NA NA hsa-let-7g-5p DTX2 -0.739744008507763 1.07979566264383e-14 1.26267931625876 4.06724284118122e-40 miRNATAP -0.323428638117989 4.25743178449699e-08 NA NA NA hsa-miR-107 DTX3 0.140046250553248 0.0943611632552367 -0.545068769946582 2.75929789992445e-05 miRanda -0.256132691107747 0.0034132790620105 NA NA NA hsa-miR-185-5p DTX3 1.05056378692621 1.31174187880682e-22 -0.545068769946582 2.75929789992445e-05 MirTarget -0.186109604089512 0.00324889422369149 NA NA NA hsa-miR-342-3p DTX3 1.4124432570595 1.07208971556131e-28 -0.545068769946582 2.75929789992445e-05 miRanda -0.26177865030156 3.83929582097566e-07 NA NA NA hsa-miR-10b-3p DTX3L -0.8205021989966 7.84331443044781e-21 0.929359762409512 1.4332320565609e-31 mirMAP -0.366035793259477 3.89449995007712e-13 NA NA NA hsa-miR-125a-3p DTX3L -0.372794471295036 0.000941729459601642 0.929359762409512 1.4332320565609e-31 miRanda -0.127222740729891 0.00297907351414192 NA NA NA hsa-miR-139-5p DTX3L -0.704802495091118 2.36904108453776e-06 0.929359762409512 1.4332320565609e-31 miRanda -0.114044322969787 0.000333077816750062 NA NA NA hsa-miR-429 DTX3L -2.16569233119434 2.66862243626443e-37 0.929359762409512 1.4332320565609e-31 miRanda -0.176141312587862 6.32837789819709e-13 NA NA NA hsa-let-7a-5p DTX4 0.0791334022258656 0.422980622613373 0.282321290389512 0.0423296106819581 TargetScan;miRNATAP -0.223064201456963 0.00441771249448262 NA NA NA hsa-let-7e-5p DTX4 -0.727009689927955 1.30690859412163e-11 0.282321290389512 0.0423296106819581 miRNATAP -0.253558267631289 0.000248320472716154 NA NA NA hsa-let-7f-5p DTX4 -0.117703832394463 0.483893124265895 0.282321290389512 0.0423296106819581 miRNATAP -0.127684746808805 0.00524200351224566 NA NA NA hsa-let-7g-5p DTX4 -0.739744008507763 1.07979566264383e-14 0.282321290389512 0.0423296106819581 miRNATAP -0.202040159446476 0.00905980575689672 NA NA NA hsa-miR-362-5p DTX4 -2.72767654824605 1.34821749679113e-49 0.282321290389512 0.0423296106819581 mirMAP -0.143921365903024 4.74706972135225e-05 NA NA NA hsa-miR-501-5p DTX4 -1.1103073934745 1.81589804886553e-16 0.282321290389512 0.0423296106819581 mirMAP -0.159454742827307 0.00330078195918933 NA NA NA hsa-miR-532-3p DTX4 -1.759223962964 7.9077916669414e-40 0.282321290389512 0.0423296106819581 miRNATAP -0.161925542845505 0.00144227661967363 NA NA NA hsa-miR-29b-2-5p DVL3 -0.297854154636098 0.00260919277325581 0.0517387826509061 0.331393289501179 MirTarget -0.146756419924725 4.57749287388624e-07 NA NA NA hsa-miR-106b-5p EP300 1.07509411417907 2.11739194181878e-36 -0.147148678710588 0.0405321000139646 miRNATAP -0.261995772265445 1.08364064661463e-10 NA NA NA hsa-miR-186-5p EP300 0.507217561043443 9.04455748270995e-10 -0.147148678710588 0.0405321000139646 miRNATAP -0.121597586405933 0.00972259491444961 NA NA NA hsa-miR-22-3p EP300 0.198460552200729 0.00761005672059428 -0.147148678710588 0.0405321000139646 MirTarget;miRNATAP -0.164572270687749 0.00217699129328605 NA NA NA hsa-miR-26b-5p EP300 -0.251437253429904 0.00270935785098697 -0.147148678710588 0.0405321000139646 miRNAWalker2_validate;miRNATAP -0.150155147849394 0.00151617840802469 NA NA NA hsa-miR-339-5p EP300 0.322848334531193 0.0117281778821612 -0.147148678710588 0.0405321000139646 miRanda -0.150136558180177 8.30541099155694e-07 NA NA NA hsa-miR-361-3p EP300 1.08992546227594 1.13197240706704e-36 -0.147148678710588 0.0405321000139646 PITA -0.124298281144442 0.00252789477423822 NA NA NA hsa-miR-28-5p HDAC1 0.461962042257226 3.32424690573327e-11 -0.26069218953464 3.16500966280369e-06 miRanda -0.135368414899127 0.00206548950372119 NA NA NA hsa-miR-374a-3p HDAC2 1.13863935833993 2.79089304015401e-44 -0.296702961466692 7.03992845213639e-07 mirMAP -0.116893509074138 0.0010971503256489 NA NA NA hsa-miR-222-3p HES1 0.214811008033524 0.0965295551752457 -0.443885576011004 0.000450253235746596 miRNAWalker2_validate -0.166962413336309 0.00215576614605654 NA NA NA hsa-miR-501-5p HES5 -1.1103073934745 1.81589804886553e-16 2.78101972942013 1.61110550310366e-25 PITA;miRNATAP -0.433580801118425 0.000107612828551093 NA NA NA hsa-miR-375 JAG1 -1.46468479447701 9.20596529469647e-07 0.548190597973491 2.82298957844723e-08 miRNAWalker2_validate -0.100970766525194 1.84276675816218e-08 NA NA NA hsa-miR-429 JAG1 -2.16569233119434 2.66862243626443e-37 0.548190597973491 2.82298957844723e-08 miRanda -0.115611448266938 6.44357328535999e-05 NA NA NA hsa-miR-509-3p JAG1 -2.24650406059054 1.08256825220159e-24 0.548190597973491 2.82298957844723e-08 PITA -0.139833030203081 1.12839890404501e-09 NA NA NA hsa-miR-598-3p JAG1 -0.0520299179503505 0.691288280883394 0.548190597973491 2.82298957844723e-08 MirTarget -0.182253700182937 1.59718643148326e-05 NA NA NA hsa-miR-182-5p JAG2 -0.608710746044567 0.0025264935278104 1.70057055074205 5.49710177655108e-32 mirMAP -0.245613635984528 8.30772682632819e-09 NA NA NA hsa-miR-200b-3p JAG2 -1.70383252137161 2.38979336321755e-30 1.70057055074205 5.49710177655108e-32 TargetScan;mirMAP -0.343456861335036 5.90908463634564e-11 21403400 The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR 200 dependent pathway in mice; Mechanistically Jagged2 was found to promote metastasis by increasing the expression of GATA-binding Gata factors which suppressed expression of the microRNA-200 miR-200 family of microRNAs that target the transcriptional repressors that drive EMT and thereby induced EMT metastasis lung cancer hsa-miR-30a-5p JAG2 -0.778411951775343 2.73322451127932e-16 1.70057055074205 5.49710177655108e-32 miRNATAP -0.365347921175483 3.47109045939332e-05 NA NA NA hsa-miR-30b-5p JAG2 -1.18330589477119 6.8341618466966e-27 1.70057055074205 5.49710177655108e-32 miRNATAP -0.467197885672483 8.24422493468899e-11 NA NA NA hsa-miR-30c-5p JAG2 -1.08783070774238 2.02505402525786e-24 1.70057055074205 5.49710177655108e-32 miRNATAP -0.507350176151496 1.13179657404079e-11 NA NA NA hsa-miR-335-5p JAG2 -2.09515619961552 1.03765771499548e-25 1.70057055074205 5.49710177655108e-32 miRNAWalker2_validate -0.30082778972652 2.89663220071638e-14 NA NA NA hsa-miR-3607-3p JAG2 -0.529788328085356 0.00511771034738625 1.70057055074205 5.49710177655108e-32 miRNATAP -0.20405459819472 8.86690362878392e-06 NA NA NA hsa-miR-429 JAG2 -2.16569233119434 2.66862243626443e-37 1.70057055074205 5.49710177655108e-32 PITA;mirMAP;miRNATAP -0.310584194188007 4.00865996020195e-12 NA NA NA hsa-miR-501-3p JAG2 -1.30538668412879 3.52127864608017e-18 1.70057055074205 5.49710177655108e-32 TargetScan;miRNATAP -0.404633468460055 4.70469136205452e-14 NA NA NA hsa-miR-502-3p JAG2 -1.10416310320528 1.55354569985732e-22 1.70057055074205 5.49710177655108e-32 miRNATAP -0.526992928721118 6.98434210122596e-14 NA NA NA hsa-miR-615-3p KAT2A -0.777370544471479 2.08193713560545e-08 0.744653011010627 1.28552980078797e-10 miRNAWalker2_validate -0.142392761451528 0.00214871715025532 NA NA NA hsa-miR-106b-5p KAT2B 1.07509411417907 2.11739194181878e-36 -0.700765552326239 6.58504875778734e-19 miRNAWalker2_validate;miRTarBase;MirTarget -0.419653600233065 4.41470614766409e-20 NA NA NA hsa-miR-140-5p KAT2B 0.504309496243674 3.09884038729031e-11 -0.700765552326239 6.58504875778734e-19 MirTarget;miRanda;miRNATAP -0.215371575134 0.000275096918634443 NA NA NA hsa-miR-142-3p KAT2B 1.88928758773299 2.72985643829893e-22 -0.700765552326239 6.58504875778734e-19 MirTarget;miRanda;miRNATAP -0.101793002975901 3.07272728430119e-06 NA NA NA hsa-miR-17-5p KAT2B 0.494260110870015 3.8348005261e-09 -0.700765552326239 6.58504875778734e-19 MirTarget;TargetScan -0.155811751670146 0.00391736791642487 23095762 miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of PCAF by miR-17-5p was evaluated using the luciferase reporter assay; Expression of PCAF in PCa cells was associated with the downregulation of miR-17-5p; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; PCAF is upregulated in cultured PCa cells and upregulation of PCAF is associated with the downregulation of miR-17-5p; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells prostate cancer hsa-miR-181a-5p KAT2B 1.11111114875339 3.97880443756442e-29 -0.700765552326239 6.58504875778734e-19 miRNAWalker2_validate;miRTarBase;MirTarget -0.25298242515596 1.21477348483024e-09 NA NA NA hsa-miR-181b-5p KAT2B 1.49054296272357 3.69051660739368e-41 -0.700765552326239 6.58504875778734e-19 miRNAWalker2_validate;miRTarBase;MirTarget -0.254422569448215 5.91171216578665e-13 NA NA NA hsa-miR-181d-5p KAT2B 1.00720380524132 6.04219503683814e-14 -0.700765552326239 6.58504875778734e-19 MirTarget -0.11183473521052 0.00066958941950678 NA NA NA hsa-miR-19a-3p KAT2B 0.722913586880779 2.76301458932381e-10 -0.700765552326239 6.58504875778734e-19 miRNAWalker2_validate -0.166616843769166 1.80756234983023e-05 NA NA NA hsa-miR-19b-3p KAT2B 0.195940928879427 0.0300512922542325 -0.700765552326239 6.58504875778734e-19 miRNAWalker2_validate -0.182191846717628 0.00036118421321627 NA NA NA hsa-miR-20a-5p KAT2B 0.702602695798242 4.06372887613329e-13 -0.700765552326239 6.58504875778734e-19 MirTarget -0.119487310165629 0.00946707200905017 NA NA NA hsa-miR-25-3p KAT2B 1.12016166564779 3.79069348635778e-48 -0.700765552326239 6.58504875778734e-19 miRNAWalker2_validate;miRTarBase;MirTarget -0.317360803778798 3.83246784367678e-10 NA NA NA hsa-miR-32-5p KAT2B 0.407826130035097 7.26884631998646e-06 -0.700765552326239 6.58504875778734e-19 miRNAWalker2_validate;miRTarBase;MirTarget -0.235209523814245 2.2842654158539e-06 NA NA NA hsa-miR-330-3p KAT2B 0.912906550436308 3.35037014057665e-13 -0.700765552326239 6.58504875778734e-19 MirTarget -0.120857327143858 0.000805711724637061 NA NA NA hsa-miR-342-3p KAT2B 1.4124432570595 1.07208971556131e-28 -0.700765552326239 6.58504875778734e-19 miRanda -0.202581804135068 3.88134058960835e-10 NA NA NA hsa-miR-361-5p KAT2B 0.0514169367202078 0.382929376393199 -0.700765552326239 6.58504875778734e-19 miRanda -0.231302026784399 0.00389954594671121 NA NA NA hsa-miR-374a-3p KAT2B 1.13863935833993 2.79089304015401e-44 -0.700765552326239 6.58504875778734e-19 MirTarget -0.320424855790528 2.65687593583013e-11 NA NA NA hsa-miR-576-5p KAT2B 1.06681109513983 5.69294424466526e-24 -0.700765552326239 6.58504875778734e-19 mirMAP -0.167385918124833 3.28715483594039e-05 NA NA NA hsa-miR-590-3p KAT2B 1.13702599385212 3.53435739887793e-22 -0.700765552326239 6.58504875778734e-19 MirTarget;miRanda;mirMAP;miRNATAP -0.22479408997905 3.78461526957045e-10 NA NA NA hsa-miR-590-5p KAT2B 0.709763558412506 1.11883921359361e-11 -0.700765552326239 6.58504875778734e-19 miRanda -0.239915382925563 1.10089572501638e-08 NA NA NA hsa-miR-92b-3p KAT2B 0.418630595140165 6.50466149211154e-05 -0.700765552326239 6.58504875778734e-19 MirTarget -0.162398501655055 0.000185940294771918 NA NA NA hsa-miR-93-5p KAT2B 1.37365940377595 2.37567548683245e-46 -0.700765552326239 6.58504875778734e-19 miRNAWalker2_validate;miRTarBase;MirTarget -0.227934510433415 2.35690699405592e-08 NA NA NA hsa-miR-200b-3p LFNG -1.70383252137161 2.38979336321755e-30 0.635855274610713 7.0591512694506e-07 TargetScan -0.165608635520011 0.000152770062639736 NA NA NA hsa-miR-429 LFNG -2.16569233119434 2.66862243626443e-37 0.635855274610713 7.0591512694506e-07 PITA;miRanda;miRNATAP -0.136505874536378 0.000272668113967984 NA NA NA hsa-miR-577 LFNG -1.48881999472397 7.03080165111147e-10 0.635855274610713 7.0591512694506e-07 MirTarget;PITA -0.116492710454542 5.57424386322078e-05 NA NA NA hsa-miR-30a-5p MAML1 -0.778411951775343 2.73322451127932e-16 0.410825984969037 7.26664124221502e-17 MirTarget;miRNATAP -0.128100825710329 6.0843750646471e-06 NA NA NA hsa-miR-30b-3p MAML1 -1.64703050862226 1.89878531036464e-31 0.410825984969037 7.26664124221502e-17 MirTarget -0.12024731024886 1.50665815206561e-11 NA NA NA hsa-miR-30b-5p MAML1 -1.18330589477119 6.8341618466966e-27 0.410825984969037 7.26664124221502e-17 MirTarget -0.139534152980522 1.94748737316004e-09 NA NA NA hsa-miR-30c-2-3p MAML1 -1.28402709024345 6.77577627955178e-25 0.410825984969037 7.26664124221502e-17 MirTarget -0.119676994012117 7.47927401043241e-09 NA NA NA hsa-miR-30c-5p MAML1 -1.08783070774238 2.02505402525786e-24 0.410825984969037 7.26664124221502e-17 MirTarget;miRNATAP -0.133477287965512 4.15140644465251e-08 NA NA NA hsa-miR-30e-5p MAML1 -0.0905907245198101 0.21196704484334 0.410825984969037 7.26664124221502e-17 MirTarget -0.104998104762087 0.00823009954079145 NA NA NA hsa-miR-429 MAML1 -2.16569233119434 2.66862243626443e-37 0.410825984969037 7.26664124221502e-17 miRNATAP -0.123574806659426 1.8700698065031e-18 NA NA NA hsa-miR-590-3p MAML2 1.13702599385212 3.53435739887793e-22 -0.238996798618611 0.0527786283905526 mirMAP -0.195732862311072 0.000306544713072607 NA NA NA hsa-miR-339-5p MAML3 0.322848334531193 0.0117281778821612 0.189746795238698 0.0257583206743516 miRanda -0.155108401028528 1.95115629796597e-05 NA NA NA hsa-miR-590-3p MAML3 1.13702599385212 3.53435739887793e-22 0.189746795238698 0.0257583206743516 miRanda -0.109785432732345 0.00340985355050558 NA NA NA hsa-miR-335-5p MFNG -2.09515619961552 1.03765771499548e-25 1.13657053086323 8.37979493718285e-29 miRNAWalker2_validate -0.146312700519152 2.32778295032825e-07 NA NA NA hsa-miR-10a-5p NCOR2 -1.17164272592931 4.86621098042279e-24 0.909364683150529 6.85668983571032e-26 miRNAWalker2_validate;MirTarget;miRNATAP -0.21190421781095 2.16855780040385e-07 NA NA NA hsa-miR-10b-5p NCOR2 -0.89971464210447 1.18190532299934e-20 0.909364683150529 6.85668983571032e-26 miRNAWalker2_validate;MirTarget;miRNATAP -0.239826086844127 1.53404515033382e-06 NA NA NA hsa-miR-125a-5p NCOR2 -0.561874059994802 7.3931856356891e-13 0.909364683150529 6.85668983571032e-26 MirTarget;PITA;miRanda -0.326165188316932 2.57351901304795e-07 NA NA NA hsa-miR-125b-5p NCOR2 -0.825456421494266 2.13029877878434e-15 0.909364683150529 6.85668983571032e-26 MirTarget;miRNATAP -0.204771122795381 1.44987624455937e-05 NA NA NA hsa-miR-200b-3p NCOR2 -1.70383252137161 2.38979336321755e-30 0.909364683150529 6.85668983571032e-26 TargetScan -0.216391618683832 1.39508360462517e-12 NA NA NA hsa-miR-30a-5p NCOR2 -0.778411951775343 2.73322451127932e-16 0.909364683150529 6.85668983571032e-26 miRNATAP -0.338154145987952 2.31383437175535e-11 NA NA NA hsa-miR-30c-5p NCOR2 -1.08783070774238 2.02505402525786e-24 0.909364683150529 6.85668983571032e-26 miRNATAP -0.399618656152847 4.05012392833592e-21 NA NA NA hsa-miR-429 NCOR2 -2.16569233119434 2.66862243626443e-37 0.909364683150529 6.85668983571032e-26 PITA;miRanda;miRNATAP -0.189304233029298 4.26904655485465e-13 NA NA NA hsa-miR-615-3p NCOR2 -0.777370544471479 2.08193713560545e-08 0.909364683150529 6.85668983571032e-26 miRanda -0.144486196858612 6.63872940014959e-05 NA NA NA hsa-miR-200b-3p NOTCH1 -1.70383252137161 2.38979336321755e-30 0.662681111031007 4.19609977664756e-12 MirTarget;TargetScan -0.198151807773386 1.2171888271418e-09 26012256;23430952 Nobiletin inhibited hypoxia induced epithelial mesenchymal transition of lung cancer cells by inactivating of Notch 1 signaling and switching on miR 200b; Our findings suggest that downregulation of Notch-1 and reexpression of miR-200b by nobiletin might be a novel remedy for the therapy of lung cancer;We also found that reexpression of miR-34a and miR-200b by transfection led to reduced expression of Notch-1 resulting in the inhibition of osteosarcoma cell proliferation invasion and angiogenesis ; lung cancer;sarcoma hsa-miR-200c-3p NOTCH1 -5.40303134829523 2.74173143360645e-94 0.662681111031007 4.19609977664756e-12 MirTarget -0.109814961936093 2.77548178951596e-13 NA NA NA hsa-miR-30a-5p NOTCH1 -0.778411951775343 2.73322451127932e-16 0.662681111031007 4.19609977664756e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.214585199069102 8.64381491702019e-05 NA NA NA hsa-miR-30b-5p NOTCH1 -1.18330589477119 6.8341618466966e-27 0.662681111031007 4.19609977664756e-12 miRNATAP -0.22230087101798 8.25378946991346e-07 NA NA NA hsa-miR-30c-5p NOTCH1 -1.08783070774238 2.02505402525786e-24 0.662681111031007 4.19609977664756e-12 miRNATAP -0.280562093460855 1.70176750861714e-09 23974200 We identified NOTCH1 as a direct target of miR-30c; Finally a block of miR-30c prevents C/EBPα-induced downregulation of Notch1 protein and leads to a reduced CD11b expression in myeloid differentiation; Our study presents the first evidence that C/EBPα miR-30c and Notch1 together play a critical role in granulocytic differentiation and AML and particularly in AML with CEBPA mutations differentiation acute myeloid leukemia hsa-miR-3607-3p NOTCH1 -0.529788328085356 0.00511771034738625 0.662681111031007 4.19609977664756e-12 miRNATAP -0.111791492918798 8.78536644659121e-05 NA NA NA hsa-miR-429 NOTCH1 -2.16569233119434 2.66862243626443e-37 0.662681111031007 4.19609977664756e-12 MirTarget;PITA;miRanda;miRNATAP -0.163872397918284 4.7644053310925e-09 NA NA NA hsa-miR-107 NOTCH2 0.140046250553248 0.0943611632552367 -0.0700565047087798 0.430301832782032 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.216729873257326 0.000221205695030684 NA NA NA hsa-miR-148a-5p NOTCH2 0.415500302855613 0.000691460831436767 -0.0700565047087798 0.430301832782032 MirTarget -0.143491957776434 0.000286489906009164 NA NA NA hsa-miR-27b-3p NOTCH2 -0.699527231242518 1.07356023759234e-15 -0.0700565047087798 0.430301832782032 miRNAWalker2_validate -0.180231909266313 0.000799391316908958 NA NA NA hsa-miR-29c-3p NOTCH2 -0.238671318446745 0.0141475322347596 -0.0700565047087798 0.430301832782032 MirTarget -0.193946527828871 0.000109529287102852 NA NA NA hsa-miR-30b-5p NOTCH2 -1.18330589477119 6.8341618466966e-27 -0.0700565047087798 0.430301832782032 mirMAP -0.217052941504026 6.92142665594373e-08 NA NA NA hsa-miR-200a-3p NOTCH3 -1.43409013664263 2.00188483717828e-20 1.10750093687632 1.28923296304965e-14 mirMAP -0.3253738304166 2.73915992627435e-11 NA NA NA hsa-miR-335-5p NOTCH3 -2.09515619961552 1.03765771499548e-25 1.10750093687632 1.28923296304965e-14 miRNAWalker2_validate -0.144381302031759 0.000169804545438757 NA NA NA hsa-miR-660-5p NOTCH3 -1.20833564582661 8.48975910642834e-23 1.10750093687632 1.28923296304965e-14 MirTarget -0.532246808369815 4.07721084377563e-19 NA NA NA hsa-miR-324-5p NOTCH4 -0.487750893426456 3.74472736457965e-05 1.46745062173201 1.59787916106182e-23 miRanda -0.376078220016415 1.74744287955784e-07 NA NA NA hsa-miR-429 NOTCH4 -2.16569233119434 2.66862243626443e-37 1.46745062173201 1.59787916106182e-23 miRNATAP -0.295003794454065 2.98556569998171e-11 NA NA NA hsa-miR-615-3p NOTCH4 -0.777370544471479 2.08193713560545e-08 1.46745062173201 1.59787916106182e-23 miRanda -0.168632350144886 0.0061474407890734 NA NA NA hsa-miR-182-5p NUMB -0.608710746044567 0.0025264935278104 0.0491827486982848 0.406183038858485 miRNATAP -0.112425169356438 3.47090972649823e-13 NA NA NA hsa-let-7e-5p NUMBL -0.727009689927955 1.30690859412163e-11 0.681297214454464 2.83260266029372e-07 miRNATAP -0.338177302972132 3.70784842966393e-07 NA NA NA hsa-let-7g-5p NUMBL -0.739744008507763 1.07979566264383e-14 0.681297214454464 2.83260266029372e-07 miRNATAP -0.220875605035992 0.00323970273134362 NA NA NA hsa-miR-362-3p NUMBL -0.753214251798232 3.0025661608035e-07 0.681297214454464 2.83260266029372e-07 miRanda;miRNATAP -0.136123288690513 0.00815546205463828 NA NA NA hsa-miR-140-5p PSEN1 0.504309496243674 3.09884038729031e-11 -0.381365150522178 9.21164607796299e-14 MirTarget;miRanda -0.155979219768955 3.10610727490787e-05 NA NA NA hsa-miR-17-5p PSEN1 0.494260110870015 3.8348005261e-09 -0.381365150522178 9.21164607796299e-14 TargetScan -0.124895548621956 0.00025338378540957 NA NA NA hsa-miR-186-5p PSEN1 0.507217561043443 9.04455748270995e-10 -0.381365150522178 9.21164607796299e-14 mirMAP -0.153607510572279 7.75300218040988e-06 NA NA NA hsa-miR-27a-3p PSEN1 0.558934437526245 1.44256383086177e-12 -0.381365150522178 9.21164607796299e-14 miRNATAP -0.236258971549425 1.5723020002032e-11 NA NA NA hsa-miR-320a PSEN1 0.412740558379182 2.02929519701706e-05 -0.381365150522178 9.21164607796299e-14 miRanda;mirMAP -0.145760071113934 8.45876503241825e-07 NA NA NA hsa-miR-330-5p PSEN1 1.44960468659754 2.12131210588035e-45 -0.381365150522178 9.21164607796299e-14 miRanda -0.154584366211109 1.54285974528465e-10 NA NA NA hsa-miR-576-5p PSEN1 1.06681109513983 5.69294424466526e-24 -0.381365150522178 9.21164607796299e-14 mirMAP -0.101004348070368 8.00138886854432e-05 NA NA NA hsa-miR-590-3p PSEN1 1.13702599385212 3.53435739887793e-22 -0.381365150522178 9.21164607796299e-14 miRanda;mirMAP -0.119059169378953 2.23143788709271e-07 NA NA NA hsa-miR-338-3p PSEN2 0.906250377628867 2.76970900371139e-15 -0.19572640820216 0.000799339348319306 miRanda -0.103418499871425 0.000114716281882436 NA NA NA hsa-miR-30c-2-3p PSENEN -1.28402709024345 6.77577627955178e-25 0.193164883251172 0.0258306512901604 MirTarget -0.129424392768495 0.00026048217453057 NA NA NA hsa-miR-10b-3p RBPJ -0.8205021989966 7.84331443044781e-21 0.199046062885449 0.00168869778997435 MirTarget;miRNATAP -0.103988710878357 0.00592296876919324 NA NA NA hsa-miR-361-5p RBPJ 0.0514169367202078 0.382929376393199 0.199046062885449 0.00168869778997435 miRanda -0.158716132477985 0.0093466790941187 NA NA NA