miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-21-5p AKT2 1.75445050487988 2.41825549682022e-23 -0.0135478038511252 0.922701697200587 miRNAWalker2_validate -0.147206602823392 0.00352458167442573 NA NA NA hsa-miR-29b-3p AKT2 -0.230693226193598 0.367461626035234 -0.0135478038511252 0.922701697200587 MirTarget -0.141689777106604 0.000224365237662475 26512921;26564501;24076586 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3;The expression of miR-29b was significantly upregualted by cisplatin treatmentwhile its target gene AKT2 was downregulated;Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis ;; ovarian cancer;gastric cancer;acute myeloid leukemia hsa-miR-106b-5p AKT3 1.70863907461894 2.04074794107142e-08 -0.748577301508132 0.0693608036068007 miRNATAP -0.368902671357459 6.63579377990938e-05 NA NA NA hsa-miR-107 AKT3 0.904627575346218 4.67936495073904e-05 -0.748577301508132 0.0693608036068007 PITA;miRanda -0.596025797372068 4.38261497597827e-06 NA NA NA hsa-miR-15b-5p AKT3 1.62046407540723 5.42152621571078e-09 -0.748577301508132 0.0693608036068007 miRNATAP -0.359857777182961 0.000407223981183838 NA NA NA hsa-miR-16-5p AKT3 1.00515772948091 5.33912942007619e-06 -0.748577301508132 0.0693608036068007 miRNAWalker2_validate;miRTarBase;miRNATAP -0.473860841884761 0.000305952592817196 NA NA NA hsa-miR-17-3p AKT3 1.31126744284937 3.24768335024185e-07 -0.748577301508132 0.0693608036068007 miRNATAP -0.520864813647553 2.25932722443508e-06 NA NA NA hsa-miR-17-5p AKT3 1.65862087862483 8.45603406215941e-08 -0.748577301508132 0.0693608036068007 TargetScan;miRNATAP -0.276276453758938 0.00270096970703173 NA NA NA hsa-miR-29a-3p AKT3 -0.113012156986374 0.615005009685815 -0.748577301508132 0.0693608036068007 miRNATAP -0.408748871699734 0.00212322174807936 NA NA NA hsa-miR-29b-3p AKT3 -0.230693226193598 0.367461626035234 -0.748577301508132 0.0693608036068007 miRNATAP -0.338134432146425 0.00361456599882575 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-32-3p AKT3 0.583525764322974 0.11837203008551 -0.748577301508132 0.0693608036068007 mirMAP -0.324144417685552 0.000230218736536503 NA NA NA hsa-miR-320b AKT3 1.11183660885284 0.000497971211648503 -0.748577301508132 0.0693608036068007 PITA;miRanda;miRNATAP -0.263235906209639 0.00390234919135454 NA NA NA hsa-miR-335-3p AKT3 2.5197689063267 2.20084506976733e-09 -0.748577301508132 0.0693608036068007 mirMAP -0.224460236877792 0.000742588100170571 NA NA NA hsa-miR-33a-3p AKT3 0.347011402017138 0.321709379745392 -0.748577301508132 0.0693608036068007 mirMAP -0.376513667394311 1.68302152281553e-05 NA NA NA hsa-miR-362-3p AKT3 -0.0349414695893027 0.913780708043777 -0.748577301508132 0.0693608036068007 miRanda -0.37545416085904 3.60412362584734e-05 NA NA NA hsa-miR-362-5p AKT3 -0.354508685915981 0.354912078595613 -0.748577301508132 0.0693608036068007 PITA;TargetScan;miRNATAP -0.231850776707854 0.00252522310690117 NA NA NA hsa-miR-501-3p AKT3 0.731876211669996 0.0270421347018303 -0.748577301508132 0.0693608036068007 miRNATAP -0.389710500003727 8.30408434984544e-06 NA NA NA hsa-miR-502-3p AKT3 -0.16442685491191 0.557471818466728 -0.748577301508132 0.0693608036068007 miRNATAP -0.502835122914366 1.28261107693995e-06 NA NA NA hsa-miR-505-3p AKT3 0.82660100642669 0.00111666333288398 -0.748577301508132 0.0693608036068007 mirMAP -0.351999859841566 0.0023495079245673 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-548v AKT3 -0.156004387355895 0.708665170641638 -0.748577301508132 0.0693608036068007 miRNATAP -0.26608196493585 0.000310856014668821 NA NA NA hsa-miR-577 AKT3 0.911619788986754 0.2256062124148 -0.748577301508132 0.0693608036068007 mirMAP -0.230357457399908 2.14832389488646e-09 NA NA NA hsa-miR-616-5p AKT3 0.834052908652744 0.0347835664029363 -0.748577301508132 0.0693608036068007 mirMAP -0.265580906698402 0.000411824587413266 NA NA NA hsa-miR-125b-5p ARRB1 -0.509303501421334 0.133265526313161 -1.74125373112733 0.000102708473029082 MirTarget -0.274187654245693 0.00426032656682364 NA NA NA hsa-miR-149-5p ARRB1 0.706277554734069 0.296848731347677 -1.74125373112733 0.000102708473029082 MirTarget -0.456424811662396 5.78372320507252e-28 NA NA NA hsa-miR-185-3p ARRB1 1.33711019171256 3.45756583967985e-05 -1.74125373112733 0.000102708473029082 MirTarget -0.30364059978902 0.00212122840644577 NA NA NA hsa-miR-22-3p ARRB1 0.0312103895892015 0.845091185648687 -1.74125373112733 0.000102708473029082 MirTarget -1.08629405216321 1.54116823046747e-07 NA NA NA hsa-miR-296-5p ARRB1 0.932146077883618 0.0602370559607489 -1.74125373112733 0.000102708473029082 MirTarget;miRNATAP -0.41851909243185 1.31132870912902e-10 NA NA NA hsa-miR-324-3p ARRB1 1.04940352369965 0.000387716796520961 -1.74125373112733 0.000102708473029082 MirTarget -0.513759553345347 1.52746194545322e-06 NA NA NA hsa-miR-331-3p ARRB1 1.04880525429426 9.99995355989124e-05 -1.74125373112733 0.000102708473029082 MirTarget;miRNATAP -0.54855468603028 2.95338330198887e-06 NA NA NA hsa-miR-455-3p ARRB1 2.29532323519288 1.85675588946527e-07 -1.74125373112733 0.000102708473029082 MirTarget -0.458832341909836 1.52076959747241e-11 NA NA NA hsa-miR-671-5p ARRB1 0.947458646379882 0.0024732430914236 -1.74125373112733 0.000102708473029082 MirTarget -0.371813138129467 0.000288577986470232 NA NA NA hsa-miR-149-5p ARRB2 0.706277554734069 0.296848731347677 0.080812210241116 0.668897530369219 miRNAWalker2_validate -0.142847600773246 7.3582247459079e-15 NA NA NA hsa-miR-199a-5p ARRB2 0.371973504507027 0.232661597228763 0.080812210241116 0.668897530369219 MirTarget;miRanda -0.15835796722797 0.00020847969248711 NA NA NA hsa-miR-199b-5p ARRB2 0.124595928096068 0.678156859366405 0.080812210241116 0.668897530369219 MirTarget;miRanda;miRNATAP -0.158324333266929 0.000374066280661202 NA NA NA hsa-miR-365a-3p ARRB2 -0.891537000455889 0.0025537650440002 0.080812210241116 0.668897530369219 MirTarget;miRNATAP -0.249592706054824 1.02133054357851e-08 NA NA NA hsa-miR-10b-5p ATF2 -0.304747636331676 0.312390370183001 -0.0211402510118752 0.898437673335987 MirTarget;miRNATAP -0.131615688052157 0.000676362787084052 NA NA NA hsa-miR-126-5p ATF2 0.41765430251855 0.0753161203651532 -0.0211402510118752 0.898437673335987 mirMAP -0.149080974896046 0.00298616280876826 NA NA NA hsa-miR-212-3p ATF2 0.960352937108106 0.00133449812322732 -0.0211402510118752 0.898437673335987 miRNATAP -0.140898430644047 0.000260454715443413 NA NA NA hsa-miR-590-3p ATF2 1.11654983899947 0.000160782154924864 -0.0211402510118752 0.898437673335987 MirTarget;miRanda;mirMAP;miRNATAP -0.11720062607551 0.00262610190811212 NA NA NA hsa-miR-192-3p BDNF 0.355565421687399 0.74117031340037 0.736006518564608 0.183812338919891 MirTarget;miRNATAP -0.106082522009255 0.00423859909260241 NA NA NA hsa-miR-29b-2-5p BDNF -1.7015307882027 2.84239251703401e-10 0.736006518564608 0.183812338919891 mirMAP -0.375479531938686 0.00761861774409137 NA NA NA hsa-miR-338-5p BDNF -1.19659203838734 0.0100316010080496 0.736006518564608 0.183812338919891 miRNATAP -0.30035007324931 0.000332002329074772 NA NA NA hsa-miR-27b-3p CACNA1A 0.0836323965901755 0.725273923274 -0.236747367762079 0.666241591804856 MirTarget -0.471700469612958 0.00464180763900017 NA NA NA hsa-miR-107 CACNA1B 0.904627575346218 4.67936495073904e-05 0.216100772199895 0.843131000063564 miRanda -1.32539488954649 0.000126295413774888 NA NA NA hsa-miR-140-3p CACNA1B -0.296251775392129 0.127539826012144 0.216100772199895 0.843131000063564 MirTarget;miRNATAP -2.29743994277145 6.62211013939416e-09 NA NA NA hsa-miR-200a-3p CACNA1B 0.717826667295984 0.193912116506827 0.216100772199895 0.843131000063564 mirMAP -0.478622979504607 0.000598543450725146 NA NA NA hsa-miR-335-5p CACNA1B 1.59953351087307 5.56170899867314e-05 0.216100772199895 0.843131000063564 miRNAWalker2_validate -0.713708053964449 0.000182778440940121 NA NA NA hsa-miR-3614-5p CACNA1B 1.10426689932954 0.00706308396674599 0.216100772199895 0.843131000063564 mirMAP;miRNATAP -1.15524243125132 2.83381632391004e-10 NA NA NA hsa-miR-362-3p CACNA1B -0.0349414695893027 0.913780708043777 0.216100772199895 0.843131000063564 MirTarget;miRNATAP -0.867645530574864 0.000325200167214047 NA NA NA hsa-miR-429 CACNA1B 1.40182602301928 0.00900426780286475 0.216100772199895 0.843131000063564 miRNATAP -0.455252462652866 0.0014508643769241 NA NA NA hsa-miR-7-1-3p CACNA1B 0.709309110750947 0.0412301737463194 0.216100772199895 0.843131000063564 MirTarget -1.03441113327882 2.41824743604167e-06 NA NA NA hsa-let-7a-3p CACNA1C 0.503048155002889 0.0411145454335299 -1.46858575552254 0.000503747135372694 MirTarget -0.585264531524551 1.75532837446506e-06 NA NA NA hsa-let-7b-3p CACNA1C 0.21838629112113 0.296038413622566 -1.46858575552254 0.000503747135372694 MirTarget -0.50922478688155 0.000585953287937176 NA NA NA hsa-let-7f-1-3p CACNA1C 1.28704406797397 1.17954701106157e-06 -1.46858575552254 0.000503747135372694 MirTarget -0.444841132905305 6.85388750730375e-05 NA NA NA hsa-miR-107 CACNA1C 0.904627575346218 4.67936495073904e-05 -1.46858575552254 0.000503747135372694 miRNATAP -0.516948485811775 0.000137244277075095 NA NA NA hsa-miR-1254 CACNA1C 0.941374574140312 0.0605480748500796 -1.46858575552254 0.000503747135372694 PITA;miRNATAP -0.414100184645329 4.35322038722176e-09 NA NA NA hsa-miR-1271-5p CACNA1C 1.15538250415776 0.00207865862606828 -1.46858575552254 0.000503747135372694 MirTarget -0.267846583798183 0.00097790370002396 NA NA NA hsa-miR-148b-5p CACNA1C 1.04409494910362 0.00195860954157389 -1.46858575552254 0.000503747135372694 mirMAP -0.344177937201318 0.00010812129015374 NA NA NA hsa-miR-149-5p CACNA1C 0.706277554734069 0.296848731347677 -1.46858575552254 0.000503747135372694 MirTarget -0.174979548256646 8.06075864285974e-05 NA NA NA hsa-miR-186-5p CACNA1C 0.149964130725901 0.434709542998771 -1.46858575552254 0.000503747135372694 mirMAP -0.634090057191113 8.58249425711923e-05 NA NA NA hsa-miR-1976 CACNA1C 0.923172654386147 0.000118514313506673 -1.46858575552254 0.000503747135372694 MirTarget -0.55645060616331 7.9827434011646e-06 NA NA NA hsa-miR-19a-3p CACNA1C 1.26669687448473 0.000105972838514412 -1.46858575552254 0.000503747135372694 MirTarget -0.503583899122865 1.66052073104921e-08 NA NA NA hsa-miR-19b-1-5p CACNA1C 1.38738648038895 1.3113681938066e-06 -1.46858575552254 0.000503747135372694 MirTarget -0.553912322092807 4.34233597086828e-08 NA NA NA hsa-miR-19b-3p CACNA1C 0.759818275708988 0.00652779573186786 -1.46858575552254 0.000503747135372694 MirTarget -0.587645421155556 2.93577607616925e-08 NA NA NA hsa-miR-200b-3p CACNA1C 0.974577911407732 0.0595020056914543 -1.46858575552254 0.000503747135372694 MirTarget;TargetScan -0.21717812276223 0.000187545458925427 NA NA NA hsa-miR-200c-3p CACNA1C 1.28185685499076 0.00369777635539177 -1.46858575552254 0.000503747135372694 MirTarget -0.412059817008212 3.41158065797348e-10 NA NA NA hsa-miR-26b-5p CACNA1C -0.301646326928219 0.160081421968103 -1.46858575552254 0.000503747135372694 MirTarget;miRNATAP -0.49609732537854 0.000558675058504707 NA NA NA hsa-miR-320a CACNA1C 0.593888711838028 0.011897419390526 -1.46858575552254 0.000503747135372694 miRNATAP -0.401801256453786 0.00196076542605746 NA NA NA hsa-miR-320b CACNA1C 1.11183660885284 0.000497971211648503 -1.46858575552254 0.000503747135372694 miRNATAP -0.406961374054485 1.25966082408375e-05 NA NA NA hsa-miR-330-5p CACNA1C 0.488365986827708 0.0512207630808233 -1.46858575552254 0.000503747135372694 miRanda -0.544487864741239 6.52630228138444e-06 NA NA NA hsa-miR-33a-5p CACNA1C 0.407757858040717 0.321429014317207 -1.46858575552254 0.000503747135372694 MirTarget -0.507083751908832 4.58064018755234e-13 NA NA NA hsa-miR-33b-5p CACNA1C 0.267227362818466 0.614814331176942 -1.46858575552254 0.000503747135372694 MirTarget -0.377661793508961 1.84449915526333e-07 NA NA NA hsa-miR-378a-5p CACNA1C -0.557166502179376 0.0344581590006454 -1.46858575552254 0.000503747135372694 MirTarget -0.527258209958304 4.0231844635669e-06 NA NA NA hsa-miR-3922-3p CACNA1C 1.33252322927569 0.000665307190249975 -1.46858575552254 0.000503747135372694 mirMAP;miRNATAP -0.326699948321131 0.000225668561685447 NA NA NA hsa-miR-421 CACNA1C 1.80720854070385 1.59709651202848e-07 -1.46858575552254 0.000503747135372694 MirTarget;PITA;miRanda;miRNATAP -0.318299552925555 0.000182132999487579 NA NA NA hsa-miR-429 CACNA1C 1.40182602301928 0.00900426780286475 -1.46858575552254 0.000503747135372694 MirTarget;PITA;miRanda;miRNATAP -0.249982359336912 6.20812303499976e-06 NA NA NA hsa-miR-484 CACNA1C 0.71327898984355 0.00233605130771196 -1.46858575552254 0.000503747135372694 PITA;miRNATAP -0.736686171839525 5.46243297195429e-09 NA NA NA hsa-miR-542-3p CACNA1C 0.757649022262991 0.00210575463285599 -1.46858575552254 0.000503747135372694 miRanda -0.330948161371237 0.00762499163124138 NA NA NA hsa-miR-577 CACNA1C 0.911619788986754 0.2256062124148 -1.46858575552254 0.000503747135372694 PITA -0.145659541478736 0.000388689990273678 NA NA NA hsa-miR-582-5p CACNA1C -0.448820171762719 0.134615974001015 -1.46858575552254 0.000503747135372694 PITA -0.352530222757305 0.000516541978193967 NA NA NA hsa-miR-589-3p CACNA1C 1.01962606923682 0.00577853347252709 -1.46858575552254 0.000503747135372694 MirTarget;mirMAP -0.268315546653245 0.00101516932690495 NA NA NA hsa-miR-671-3p CACNA1C 1.16199446005059 0.000404240109143589 -1.46858575552254 0.000503747135372694 miRNATAP -0.516686199817836 1.20525936088091e-08 NA NA NA hsa-miR-7-1-3p CACNA1C 0.709309110750947 0.0412301737463194 -1.46858575552254 0.000503747135372694 MirTarget -0.28546303015123 0.00107481444559373 NA NA NA hsa-miR-877-5p CACNA1C 2.17859965442336 1.03593450648516e-07 -1.46858575552254 0.000503747135372694 MirTarget -0.383264239220556 4.1858390752617e-08 NA NA NA hsa-miR-93-3p CACNA1C 1.88964231421793 1.80075645722786e-08 -1.46858575552254 0.000503747135372694 mirMAP -0.59105808427855 1.08506588671688e-12 NA NA NA hsa-miR-944 CACNA1C 3.33123095809751 0.0177835044930391 -1.46858575552254 0.000503747135372694 mirMAP -0.111174051336113 9.87242598358089e-06 NA NA NA hsa-miR-96-5p CACNA1C 1.14243043653372 0.00942969392739105 -1.46858575552254 0.000503747135372694 MirTarget;TargetScan -0.472814181732202 5.31499731628801e-12 NA NA NA hsa-let-7a-2-3p CACNA1D 0.195895719455896 0.643556335039042 -0.147910389703389 0.86217146685178 MirTarget -0.478340521653215 0.000985557475883325 NA NA NA hsa-let-7b-5p CACNA1D 0.0582902155815681 0.781400138984745 -0.147910389703389 0.86217146685178 miRNATAP -1.39585415215589 1.39239615902824e-06 NA NA NA hsa-miR-134-5p CACNA1D 0.565477776815981 0.109621868298098 -0.147910389703389 0.86217146685178 MirTarget -0.800541768141812 2.01570537175252e-06 NA NA NA hsa-miR-203a-3p CACNA1E 1.44736908507496 0.0394116388736904 -0.449145594651123 0.534506592876781 MirTarget -0.227976248433298 0.00165285876449184 NA NA NA hsa-miR-205-5p CACNA1E 3.13520672931882 0.0293226471971167 -0.449145594651123 0.534506592876781 mirMAP -0.112656685471525 0.00145305691340137 NA NA NA hsa-miR-151a-3p CACNA1G 1.00322719901751 7.20903658270795e-06 -0.551781823520134 0.311827714537797 MirTarget -0.490161405918473 0.00446185631365654 NA NA NA hsa-miR-32-5p CACNA1H 0.415247682945382 0.106458022460373 -2.22302521566836 1.05879155502359e-05 miRNATAP -0.720919974827899 3.177491071011e-07 NA NA NA hsa-miR-361-3p CACNA1H -0.126462931388735 0.566052688733137 -2.22302521566836 1.05879155502359e-05 MirTarget;mirMAP -0.442497531813265 0.00939930905575368 NA NA NA hsa-miR-92a-3p CACNA1H 1.2209325870225 6.8757197708107e-06 -2.22302521566836 1.05879155502359e-05 miRNATAP -0.982134649002207 3.2590447163285e-15 NA NA NA hsa-let-7f-1-3p CACNA2D1 1.28704406797397 1.17954701106157e-06 -1.61149566086168 0.0253728287941273 mirMAP -0.717020614648347 0.000156144613761107 NA NA NA hsa-miR-107 CACNA2D1 0.904627575346218 4.67936495073904e-05 -1.61149566086168 0.0253728287941273 PITA;miRanda;miRNATAP -1.07143290565546 2.45653773150106e-06 NA NA NA hsa-miR-141-3p CACNA2D1 1.45548825076434 0.00115958850961764 -1.61149566086168 0.0253728287941273 TargetScan -0.326007992068883 0.00413095598387282 NA NA NA hsa-miR-16-2-3p CACNA2D1 1.8048179609245 2.83095715136409e-09 -1.61149566086168 0.0253728287941273 mirMAP -0.490538236564749 0.00268065364876341 NA NA NA hsa-miR-16-5p CACNA2D1 1.00515772948091 5.33912942007619e-06 -1.61149566086168 0.0253728287941273 miRNAWalker2_validate -1.06080229769426 3.20029154632446e-06 NA NA NA hsa-miR-181b-5p CACNA2D1 1.64216500592669 1.89228845300725e-08 -1.61149566086168 0.0253728287941273 mirMAP -0.445495856057256 0.00933634086548664 NA NA NA hsa-miR-200b-3p CACNA2D1 0.974577911407732 0.0595020056914543 -1.61149566086168 0.0253728287941273 TargetScan -0.316874566154081 0.00136361754385376 NA NA NA hsa-miR-32-3p CACNA2D1 0.583525764322974 0.11837203008551 -1.61149566086168 0.0253728287941273 mirMAP -0.439825943432451 0.00468240050625761 NA NA NA hsa-miR-330-3p CACNA2D1 0.798460296022179 0.00746538156533435 -1.61149566086168 0.0253728287941273 mirMAP -0.698672602423026 4.28561365392604e-05 NA NA NA hsa-miR-335-3p CACNA2D1 2.5197689063267 2.20084506976733e-09 -1.61149566086168 0.0253728287941273 mirMAP -0.429075005328396 0.000228125408564931 NA NA NA hsa-miR-33a-3p CACNA2D1 0.347011402017138 0.321709379745392 -1.61149566086168 0.0253728287941273 mirMAP -0.454156933141431 0.0034929310658874 NA NA NA hsa-miR-96-5p CACNA2D1 1.14243043653372 0.00942969392739105 -1.61149566086168 0.0253728287941273 TargetScan;miRNATAP -0.387198874515693 0.00147294187907071 NA NA NA hsa-miR-182-5p CACNA2D2 0.887369486030646 0.0310640781418789 -3.00042237541873 8.97347530108893e-08 miRNATAP -0.264529633770684 0.00833055303353755 NA NA NA hsa-miR-205-5p CACNA2D2 3.13520672931882 0.0293226471971167 -3.00042237541873 8.97347530108893e-08 miRNATAP -0.121537300483999 1.57195644292631e-05 NA NA NA hsa-miR-22-5p CACNA2D2 0.804348748654247 0.000804065112767412 -3.00042237541873 8.97347530108893e-08 mirMAP -0.540664431490398 0.00168453526011449 NA NA NA hsa-miR-3614-5p CACNA2D2 1.10426689932954 0.00706308396674599 -3.00042237541873 8.97347530108893e-08 mirMAP -0.330528954483581 0.00109199999290502 NA NA NA hsa-miR-455-3p CACNA2D2 2.29532323519288 1.85675588946527e-07 -3.00042237541873 8.97347530108893e-08 PITA;miRNATAP -0.482605954408931 4.74880409015542e-08 NA NA NA hsa-miR-18a-3p CACNA2D3 2.35188582849667 1.39401350286321e-08 -2.0857314014298 0.00344361978806513 miRNAWalker2_validate -0.524200617519356 8.08288108640837e-06 NA NA NA hsa-miR-429 CACNA2D3 1.40182602301928 0.00900426780286475 -2.0857314014298 0.00344361978806513 miRanda -0.250551493331922 0.00817001909798577 NA NA NA hsa-miR-615-3p CACNA2D3 2.82967143704683 3.05118423223543e-05 -2.0857314014298 0.00344361978806513 miRanda -0.363446300379859 0.000367482167312343 NA NA NA hsa-miR-299-5p CACNB1 -0.173288988251251 0.638938431622539 0.76641577362111 0.00893724493782052 miRNATAP -0.164344219473942 0.00454860520795333 NA NA NA hsa-let-7a-3p CACNB2 0.503048155002889 0.0411145454335299 -2.08567115391524 7.32991608165089e-06 MirTarget;mirMAP -0.65314787368803 1.65600613788594e-06 NA NA NA hsa-let-7b-3p CACNB2 0.21838629112113 0.296038413622566 -2.08567115391524 7.32991608165089e-06 MirTarget;mirMAP -0.768478835561693 2.3259375870054e-06 NA NA NA hsa-let-7f-1-3p CACNB2 1.28704406797397 1.17954701106157e-06 -2.08567115391524 7.32991608165089e-06 MirTarget;mirMAP -0.709658122174709 5.27838943610188e-09 NA NA NA hsa-miR-103a-2-5p CACNB2 0.808041560899298 0.019989162317947 -2.08567115391524 7.32991608165089e-06 MirTarget -0.321719041248488 0.000947583263859709 NA NA NA hsa-miR-144-5p CACNB2 -0.644861505244731 0.173474442191587 -2.08567115391524 7.32991608165089e-06 mirMAP -0.262757823932099 0.00021052841849566 NA NA NA hsa-miR-16-5p CACNB2 1.00515772948091 5.33912942007619e-06 -2.08567115391524 7.32991608165089e-06 miRNAWalker2_validate -0.989938763587007 8.94150233817054e-12 NA NA NA hsa-miR-181a-5p CACNB2 1.39227281909646 1.91689469974826e-09 -2.08567115391524 7.32991608165089e-06 miRNATAP -0.508897788429133 0.000309345008317799 NA NA NA hsa-miR-181b-5p CACNB2 1.64216500592669 1.89228845300725e-08 -2.08567115391524 7.32991608165089e-06 miRNATAP -0.447121987532514 5.89012835847503e-05 NA NA NA hsa-miR-182-5p CACNB2 0.887369486030646 0.0310640781418789 -2.08567115391524 7.32991608165089e-06 miRNATAP -0.484849809320334 8.53113478379811e-10 NA NA NA hsa-miR-200c-5p CACNB2 0.840328528720891 0.0574610665063827 -2.08567115391524 7.32991608165089e-06 MirTarget;miRNATAP -0.240153557401257 0.00450527285363786 NA NA NA hsa-miR-23a-3p CACNB2 1.10685926969665 3.16223452471768e-08 -2.08567115391524 7.32991608165089e-06 mirMAP -0.909656780540606 1.95023920715064e-08 NA NA NA hsa-miR-27a-3p CACNB2 1.29886998470345 2.68986118553486e-08 -2.08567115391524 7.32991608165089e-06 MirTarget;miRNATAP -0.869520347343534 1.63075255040338e-10 NA NA NA hsa-miR-29a-5p CACNB2 0.585084040404152 0.023014129158495 -2.08567115391524 7.32991608165089e-06 MirTarget -0.382251941517964 0.00392180578969573 NA NA NA hsa-miR-31-5p CACNB2 0.666358292391859 0.381800494600846 -2.08567115391524 7.32991608165089e-06 MirTarget;miRNATAP -0.235252435007893 2.57227564585711e-07 NA NA NA hsa-miR-32-3p CACNB2 0.583525764322974 0.11837203008551 -2.08567115391524 7.32991608165089e-06 mirMAP;miRNATAP -0.367984902946928 0.000290683969444078 NA NA NA hsa-miR-339-5p CACNB2 0.770566566962108 0.00816529093411862 -2.08567115391524 7.32991608165089e-06 miRNATAP -0.506303724068543 1.01325953954997e-05 NA NA NA hsa-miR-3653-3p CACNB2 0.599121955934704 0.0943943486072891 -2.08567115391524 7.32991608165089e-06 MirTarget -0.264520320416262 0.00537298820873901 NA NA NA hsa-miR-369-3p CACNB2 0.32261175629684 0.3589927609891 -2.08567115391524 7.32991608165089e-06 PITA -0.257252049353305 0.00791864429787648 NA NA NA hsa-miR-370-3p CACNB2 1.02953147036298 0.00666384291823188 -2.08567115391524 7.32991608165089e-06 MirTarget -0.273663443671866 0.00201874454643972 NA NA NA hsa-miR-429 CACNB2 1.40182602301928 0.00900426780286475 -2.08567115391524 7.32991608165089e-06 PITA;miRanda;miRNATAP -0.283175241229567 4.18062945762259e-06 NA NA NA hsa-miR-550a-3p CACNB2 2.05849884025997 7.99642185793604e-07 -2.08567115391524 7.32991608165089e-06 MirTarget;miRNATAP -0.445101426152812 1.79001461027871e-07 NA NA NA hsa-miR-590-3p CACNB2 1.11654983899947 0.000160782154924864 -2.08567115391524 7.32991608165089e-06 mirMAP -0.607051155087833 3.72813653319204e-08 NA NA NA hsa-miR-615-3p CACNB2 2.82967143704683 3.05118423223543e-05 -2.08567115391524 7.32991608165089e-06 miRanda -0.313948997505797 2.49151379396104e-06 NA NA NA hsa-miR-654-5p CACNB2 0.972762125372776 0.00586241685907749 -2.08567115391524 7.32991608165089e-06 MirTarget -0.268823895288373 0.00720711548590932 NA NA NA hsa-miR-7-1-3p CACNB2 0.709309110750947 0.0412301737463194 -2.08567115391524 7.32991608165089e-06 mirMAP -0.273456801989873 0.00505894695643122 NA NA NA hsa-miR-93-3p CACNB2 1.88964231421793 1.80075645722786e-08 -2.08567115391524 7.32991608165089e-06 MirTarget;miRNATAP -0.509484701359069 8.23070158117664e-08 NA NA NA hsa-miR-96-5p CACNB2 1.14243043653372 0.00942969392739105 -2.08567115391524 7.32991608165089e-06 miRNATAP -0.49590356928915 1.13010364280772e-10 NA NA NA hsa-miR-140-3p CACNB3 -0.296251775392129 0.127539826012144 0.574134857782722 0.0122980429616834 PITA;miRNATAP -0.254462181354305 0.00311953070379388 NA NA NA hsa-miR-186-5p CACNB3 0.149964130725901 0.434709542998771 0.574134857782722 0.0122980429616834 miRNATAP -0.411530153626522 1.65035562156467e-06 NA NA NA hsa-miR-339-5p CACNB3 0.770566566962108 0.00816529093411862 0.574134857782722 0.0122980429616834 miRanda -0.149786874495582 0.00770508236828372 NA NA NA hsa-miR-361-3p CACNB3 -0.126462931388735 0.566052688733137 0.574134857782722 0.0122980429616834 mirMAP -0.404423929572967 3.83527906561048e-08 NA NA NA hsa-let-7d-5p CACNB4 0.981733854788227 7.26366577706469e-07 -2.12386554597165 0.000212650700976849 miRNATAP -0.609208905597457 0.00336803809054193 NA NA NA hsa-miR-107 CACNB4 0.904627575346218 4.67936495073904e-05 -2.12386554597165 0.000212650700976849 miRanda -0.51789302742783 0.0054402219865733 NA NA NA hsa-miR-15b-3p CACNB4 1.75738933306437 3.00554466232543e-08 -2.12386554597165 0.000212650700976849 mirMAP -0.382067244730823 0.00251649374900519 NA NA NA hsa-miR-15b-5p CACNB4 1.62046407540723 5.42152621571078e-09 -2.12386554597165 0.000212650700976849 miRNATAP -0.420897024716134 0.00355362552953227 NA NA NA hsa-miR-183-5p CACNB4 1.65900927871187 0.000522025364980187 -2.12386554597165 0.000212650700976849 miRNATAP -0.264937447172699 0.00189017045331537 NA NA NA hsa-miR-196a-5p CACNB4 6.59255881689547 1.53691144193899e-22 -2.12386554597165 0.000212650700976849 miRNATAP -0.226255888699641 2.70988697829247e-05 NA NA NA hsa-miR-196b-5p CACNB4 5.58954708296963 1.12099152907987e-19 -2.12386554597165 0.000212650700976849 miRNATAP -0.226879220601751 0.000167765913683632 NA NA NA hsa-miR-20a-3p CACNB4 1.13957127410163 0.000451087640268489 -2.12386554597165 0.000212650700976849 miRNATAP -0.422212147091445 0.000804000619644293 NA NA NA hsa-miR-320b CACNB4 1.11183660885284 0.000497971211648503 -2.12386554597165 0.000212650700976849 PITA;miRanda -0.36130794716444 0.00502451740872611 NA NA NA hsa-miR-335-3p CACNB4 2.5197689063267 2.20084506976733e-09 -2.12386554597165 0.000212650700976849 mirMAP -0.274981449589953 0.00352461368109413 NA NA NA hsa-miR-421 CACNB4 1.80720854070385 1.59709651202848e-07 -2.12386554597165 0.000212650700976849 PITA;miRanda;miRNATAP -0.319969106045229 0.00616764837432565 NA NA NA hsa-miR-455-5p CACNB4 1.20462751989145 6.74386011867484e-05 -2.12386554597165 0.000212650700976849 PITA;miRanda;miRNATAP -0.414998234367463 0.00216142598794654 NA NA NA hsa-miR-550a-3p CACNB4 2.05849884025997 7.99642185793604e-07 -2.12386554597165 0.000212650700976849 miRNATAP -0.536202506091197 2.8384952794457e-07 NA NA NA hsa-miR-92a-3p CACNB4 1.2209325870225 6.8757197708107e-06 -2.12386554597165 0.000212650700976849 mirMAP -0.500314787145614 0.000847981215537789 NA NA NA hsa-miR-3614-5p CACNG4 1.10426689932954 0.00706308396674599 -0.324575127296216 0.725591511071985 mirMAP -0.608189483933649 0.000146315215850177 NA NA NA hsa-miR-335-5p CD14 1.59953351087307 5.56170899867314e-05 1.02785725057018 0.00498748892993275 miRNAWalker2_validate -0.169980888654412 0.00898313848071152 NA NA NA hsa-miR-148a-3p CDC25B -1.53721533763578 3.55533747293117e-05 2.46035095515554 2.56407253133031e-15 miRNAWalker2_validate;miRNATAP -0.190871502462654 0.0024238869617265 25341915 Gene CDC25B might be the target gene of miR-148a according to the results of targetscan; CDC25B may be the target gene of miR-148a that plays a role in tumor suppressor gastric cancer hsa-miR-152-3p CHUK 0.436002345388935 0.161701199884702 -0.111597771177896 0.436110414435051 MirTarget -0.173337618013613 3.78615463498576e-08 NA NA NA hsa-miR-195-5p CHUK -0.907998841926297 0.00150511564650591 -0.111597771177896 0.436110414435051 miRNAWalker2_validate;MirTarget -0.133199766126432 0.000124702259663161 NA NA NA hsa-miR-23a-3p CHUK 1.10685926969665 3.16223452471768e-08 -0.111597771177896 0.436110414435051 MirTarget -0.16996459977061 0.000556739825154491 NA NA NA hsa-miR-23b-3p CHUK -0.286465516491361 0.18664668472995 -0.111597771177896 0.436110414435051 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.186735010864747 6.42002077885917e-05 NA NA NA hsa-miR-342-3p CHUK 0.318119432680668 0.269150960124243 -0.111597771177896 0.436110414435051 miRanda -0.186912661037413 4.74504057766316e-08 NA NA NA hsa-miR-497-5p CHUK -0.801030912431774 0.00360386743876612 -0.111597771177896 0.436110414435051 MirTarget -0.109322835458534 0.00272843002977532 NA NA NA hsa-miR-107 CRKL 0.904627575346218 4.67936495073904e-05 0.499788934414131 0.0126050184834769 miRNAWalker2_validate -0.221070639989894 0.000518702996145078 NA NA NA hsa-miR-140-5p CRKL 0.208193069681326 0.303002433893804 0.499788934414131 0.0126050184834769 MirTarget;miRanda -0.230432620382433 0.0013737043684301 NA NA NA hsa-miR-181c-5p CRKL 0.336826967681288 0.112932307913601 0.499788934414131 0.0126050184834769 mirMAP -0.23240071306887 0.000636498642194116 NA NA NA hsa-miR-195-5p CRKL -0.907998841926297 0.00150511564650591 0.499788934414131 0.0126050184834769 MirTarget;miRNATAP -0.132882449126281 0.00754052018867263 NA NA NA hsa-miR-217 CRKL -0.0121404731225336 0.980818372851502 0.499788934414131 0.0126050184834769 miRanda -0.103962984814801 0.000207741307433719 NA NA NA hsa-miR-29a-3p CRKL -0.113012156986374 0.615005009685815 0.499788934414131 0.0126050184834769 miRNAWalker2_validate -0.228709001329325 0.000372818384776282 NA NA NA hsa-miR-30a-5p CRKL -1.71922855140016 3.20574349285256e-07 0.499788934414131 0.0126050184834769 MirTarget;mirMAP;miRNATAP -0.188580083471925 3.25116644475774e-06 NA NA NA hsa-miR-30b-5p CRKL -0.430720743745757 0.0593564057320791 0.499788934414131 0.0126050184834769 MirTarget;mirMAP -0.26180510959493 2.80473645849389e-05 NA NA NA hsa-miR-30c-5p CRKL -0.983130268805942 4.60419218706127e-05 0.499788934414131 0.0126050184834769 MirTarget;mirMAP;miRNATAP -0.199523529540249 0.000644986517321104 NA NA NA hsa-miR-30d-5p CRKL -0.5492586056147 0.0140125082460125 0.499788934414131 0.0126050184834769 MirTarget;mirMAP;miRNATAP -0.26084602587719 4.3292958064758e-05 NA NA NA hsa-miR-32-5p CRKL 0.415247682945382 0.106458022460373 0.499788934414131 0.0126050184834769 miRNAWalker2_validate;mirMAP -0.174417253083641 0.00179338251796692 NA NA NA hsa-miR-335-5p CRKL 1.59953351087307 5.56170899867314e-05 0.499788934414131 0.0126050184834769 miRNATAP -0.115368380361613 0.00103570604433944 NA NA NA hsa-miR-497-5p CRKL -0.801030912431774 0.00360386743876612 0.499788934414131 0.0126050184834769 MirTarget;miRNATAP -0.137623099374812 0.00798396624089926 NA NA NA hsa-let-7g-5p DUSP1 0.325297685027927 0.241142963826631 -1.18621925887263 0.0059068461177189 miRNATAP -0.307811436529932 0.00617981539860089 NA NA NA hsa-miR-141-3p DUSP1 1.45548825076434 0.00115958850961764 -1.18621925887263 0.0059068461177189 TargetScan -0.268134059037249 7.02438361067823e-05 NA NA NA hsa-miR-186-5p DUSP1 0.149964130725901 0.434709542998771 -1.18621925887263 0.0059068461177189 mirMAP -0.616664421610539 0.000171772617043947 NA NA NA hsa-miR-200b-3p DUSP1 0.974577911407732 0.0595020056914543 -1.18621925887263 0.0059068461177189 MirTarget;TargetScan -0.30723311145538 1.14885869680494e-07 NA NA NA hsa-miR-200c-3p DUSP1 1.28185685499076 0.00369777635539177 -1.18621925887263 0.0059068461177189 MirTarget;miRNATAP -0.283910070795912 3.410522881843e-05 NA NA NA hsa-miR-324-3p DUSP1 1.04940352369965 0.000387716796520961 -1.18621925887263 0.0059068461177189 MirTarget -0.291100720613262 0.00501050277178719 NA NA NA hsa-miR-425-3p DUSP1 0.510948213645273 0.0697930025173473 -1.18621925887263 0.0059068461177189 MirTarget -0.405055678060359 0.000216811937542986 NA NA NA hsa-miR-429 DUSP1 1.40182602301928 0.00900426780286475 -1.18621925887263 0.0059068461177189 MirTarget;PITA;miRanda;miRNATAP -0.315643295303121 1.1287476427101e-08 NA NA NA hsa-miR-186-5p DUSP10 0.149964130725901 0.434709542998771 1.14304795088883 0.000408079747272551 mirMAP -0.355374832102964 0.00439137170984058 NA NA NA hsa-miR-107 DUSP14 0.904627575346218 4.67936495073904e-05 0.926717982631571 0.0023563479968413 miRanda -0.25787144446991 0.00872116392215481 NA NA NA hsa-miR-26b-5p DUSP14 -0.301646326928219 0.160081421968103 0.926717982631571 0.0023563479968413 miRNAWalker2_validate -0.347426449662471 0.000771355028606087 NA NA NA hsa-miR-628-5p DUSP14 -0.535322919688788 0.0377881249470294 0.926717982631571 0.0023563479968413 PITA -0.315576357892117 0.000199727582240486 NA NA NA hsa-miR-103a-2-5p DUSP3 0.808041560899298 0.019989162317947 -0.881807286220258 5.76536810491046e-07 MirTarget -0.147610601466797 5.49514354346639e-05 NA NA NA hsa-miR-1271-5p DUSP3 1.15538250415776 0.00207865862606828 -0.881807286220258 5.76536810491046e-07 mirMAP -0.157387137114015 3.16700035676444e-06 NA NA NA hsa-miR-130b-5p DUSP3 0.701350393759937 0.0510142718395002 -0.881807286220258 5.76536810491046e-07 MirTarget -0.181138320979914 1.99644009021639e-07 NA NA NA hsa-miR-141-3p DUSP3 1.45548825076434 0.00115958850961764 -0.881807286220258 5.76536810491046e-07 MirTarget;TargetScan;miRNATAP -0.128631502304586 3.75940330244278e-06 NA NA NA hsa-miR-15a-5p DUSP3 1.03783090449383 7.40334108980898e-07 -0.881807286220258 5.76536810491046e-07 MirTarget;miRNATAP -0.244057578281919 4.71034428029555e-05 NA NA NA hsa-miR-15b-5p DUSP3 1.62046407540723 5.42152621571078e-09 -0.881807286220258 5.76536810491046e-07 MirTarget;miRNATAP -0.197542413429603 7.1873210820297e-06 NA NA NA hsa-miR-16-5p DUSP3 1.00515772948091 5.33912942007619e-06 -0.881807286220258 5.76536810491046e-07 MirTarget;miRNATAP -0.326419433331983 4.89110466436722e-09 NA NA NA hsa-miR-182-5p DUSP3 0.887369486030646 0.0310640781418789 -0.881807286220258 5.76536810491046e-07 mirMAP -0.165442878458162 4.35392697214646e-08 NA NA NA hsa-miR-186-5p DUSP3 0.149964130725901 0.434709542998771 -0.881807286220258 5.76536810491046e-07 mirMAP -0.247244202264463 0.000292262177357374 NA NA NA hsa-miR-193b-5p DUSP3 0.609581100028941 0.13923921336815 -0.881807286220258 5.76536810491046e-07 MirTarget -0.11578143295269 0.000176789121291444 NA NA NA hsa-miR-197-3p DUSP3 0.888854270009261 0.000195183808214449 -0.881807286220258 5.76536810491046e-07 mirMAP -0.23713421482041 7.26189953702183e-06 NA NA NA hsa-miR-221-3p DUSP3 1.33496247538338 3.82022531235275e-07 -0.881807286220258 5.76536810491046e-07 mirMAP -0.239499438813588 2.93402580142946e-07 NA NA NA hsa-miR-320a DUSP3 0.593888711838028 0.011897419390526 -0.881807286220258 5.76536810491046e-07 mirMAP -0.146357892622943 0.00765881822248586 NA NA NA hsa-miR-320b DUSP3 1.11183660885284 0.000497971211648503 -0.881807286220258 5.76536810491046e-07 mirMAP -0.157159134986799 6.7710613922639e-05 NA NA NA hsa-miR-361-5p DUSP3 0.407725414130987 0.0181260969156347 -0.881807286220258 5.76536810491046e-07 miRNAWalker2_validate;miRanda -0.232103611418497 0.00239147046494625 NA NA NA hsa-miR-3614-3p DUSP3 0.816988052098069 0.0143572924352078 -0.881807286220258 5.76536810491046e-07 mirMAP -0.106056665822911 0.00780530405057906 NA NA NA hsa-miR-3913-5p DUSP3 0.878857760706319 0.00310224428304055 -0.881807286220258 5.76536810491046e-07 MirTarget -0.155227290381423 0.000309893689579398 NA NA NA hsa-miR-424-5p DUSP3 1.08509868581983 0.000420473853818268 -0.881807286220258 5.76536810491046e-07 MirTarget;miRNATAP -0.197856797417391 1.06252635552917e-06 NA NA NA hsa-miR-484 DUSP3 0.71327898984355 0.00233605130771196 -0.881807286220258 5.76536810491046e-07 mirMAP -0.298913223983187 2.2112044540362e-08 NA NA NA hsa-miR-590-3p DUSP3 1.11654983899947 0.000160782154924864 -0.881807286220258 5.76536810491046e-07 MirTarget;miRanda;mirMAP -0.213942960222483 3.49339921464587e-07 NA NA NA hsa-miR-136-5p DUSP4 -0.392356229753493 0.199261817142042 -0.844861726801498 0.175998941637251 mirMAP -0.412910525818646 0.00479459669044636 NA NA NA hsa-miR-193b-3p DUSP4 0.281752012268679 0.451258902263119 -0.844861726801498 0.175998941637251 mirMAP -0.791564653921893 2.78861653674815e-12 NA NA NA hsa-miR-199a-5p DUSP4 0.371973504507027 0.232661597228763 -0.844861726801498 0.175998941637251 miRanda -0.759457661547851 5.359598958783e-08 NA NA NA hsa-miR-199b-5p DUSP4 0.124595928096068 0.678156859366405 -0.844861726801498 0.175998941637251 miRanda -0.505437513774077 0.000676062685111851 NA NA NA hsa-miR-205-5p DUSP4 3.13520672931882 0.0293226471971167 -0.844861726801498 0.175998941637251 mirMAP -0.237065507565725 6.98071730303886e-17 NA NA NA hsa-miR-2355-3p DUSP4 0.982963823342009 0.0229275810851348 -0.844861726801498 0.175998941637251 mirMAP -0.401239026765658 0.000100474029247437 NA NA NA hsa-miR-23a-3p DUSP4 1.10685926969665 3.16223452471768e-08 -0.844861726801498 0.175998941637251 mirMAP -1.33749861578144 1.9524449124309e-10 NA NA NA hsa-miR-23b-3p DUSP4 -0.286465516491361 0.18664668472995 -0.844861726801498 0.175998941637251 mirMAP -1.08788538065396 8.9520253218633e-08 NA NA NA hsa-miR-452-5p DUSP4 2.08756506185889 0.000258095769002813 -0.844861726801498 0.175998941637251 mirMAP -0.592008657427014 5.8291056246983e-17 NA NA NA hsa-miR-9-3p DUSP4 0.330346058941473 0.541111939982661 -0.844861726801498 0.175998941637251 mirMAP -0.42337341974317 4.43432567580525e-07 NA NA NA hsa-miR-944 DUSP4 3.33123095809751 0.0177835044930391 -0.844861726801498 0.175998941637251 mirMAP -0.304158733538484 4.73259914192332e-19 NA NA NA hsa-miR-429 DUSP5 1.40182602301928 0.00900426780286475 -0.16595340858903 0.738332988638623 miRNATAP -0.182422122893001 0.00512600926126295 NA NA NA hsa-miR-92a-3p DUSP5 1.2209325870225 6.8757197708107e-06 -0.16595340858903 0.738332988638623 MirTarget;miRNATAP -0.372825865827766 0.00359544700319341 NA NA NA hsa-miR-107 DUSP7 0.904627575346218 4.67936495073904e-05 0.985716730702332 0.0119658699514297 miRanda -0.417909858726936 0.000873089202022512 NA NA NA hsa-miR-10a-5p DUSP7 -0.470861534765518 0.148803248989189 0.985716730702332 0.0119658699514297 mirMAP -0.500653501241385 1.90596355468767e-09 NA NA NA hsa-miR-129-5p DUSP7 -2.56914016541176 2.36237896095709e-06 0.985716730702332 0.0119658699514297 miRanda -0.147154924864081 0.00391297129895567 NA NA NA hsa-miR-186-5p DUSP7 0.149964130725901 0.434709542998771 0.985716730702332 0.0119658699514297 mirMAP -0.646632558526502 1.27565202954957e-05 NA NA NA hsa-miR-200b-3p DUSP7 0.974577911407732 0.0595020056914543 0.985716730702332 0.0119658699514297 TargetScan -0.1716829651258 0.0014376542029883 NA NA NA hsa-miR-29b-3p DUSP7 -0.230693226193598 0.367461626035234 0.985716730702332 0.0119658699514297 mirMAP -0.364739008105357 0.000977918834811507 NA NA NA hsa-miR-29c-3p DUSP7 -1.62454036584589 5.38376515586029e-07 0.985716730702332 0.0119658699514297 mirMAP -0.294764381364868 0.000446373219336193 NA NA NA hsa-miR-3200-3p DUSP7 0.93510295722357 0.0984236007399256 0.985716730702332 0.0119658699514297 mirMAP -0.153125565385296 0.00545603117899538 NA NA NA hsa-miR-326 DUSP7 -0.429748586406214 0.2629894124021 0.985716730702332 0.0119658699514297 miRanda;mirMAP -0.398541507091223 3.02413509078983e-08 NA NA NA hsa-miR-335-5p DUSP7 1.59953351087307 5.56170899867314e-05 0.985716730702332 0.0119658699514297 mirMAP -0.301567256976524 1.06200996137862e-05 NA NA NA hsa-miR-362-5p DUSP7 -0.354508685915981 0.354912078595613 0.985716730702332 0.0119658699514297 mirMAP -0.52302075218756 3.3778086209007e-14 NA NA NA hsa-miR-502-5p DUSP7 -0.260297419808178 0.520453580478988 0.985716730702332 0.0119658699514297 mirMAP -0.288710626423999 2.99855205029228e-05 NA NA NA hsa-miR-532-3p DUSP7 0.552364451472481 0.0975490365586023 0.985716730702332 0.0119658699514297 mirMAP -0.376528855608971 5.80973745002297e-06 NA NA NA hsa-miR-625-5p DUSP7 0.537211086526376 0.203801009380384 0.985716730702332 0.0119658699514297 mirMAP -0.42279731862897 3.37802586860065e-11 NA NA NA hsa-miR-642a-5p DUSP7 -0.626411225079539 0.175275421929086 0.985716730702332 0.0119658699514297 mirMAP -0.211380032221078 0.00104339137417823 NA NA NA hsa-miR-24-3p DUSP8 1.08578167539644 6.18549359075268e-07 -0.377360083984294 0.301632819949477 MirTarget;miRNATAP -0.343876768851096 0.00348243608426475 NA NA NA hsa-miR-296-5p DUSP8 0.932146077883618 0.0602370559607489 -0.377360083984294 0.301632819949477 mirMAP -0.207938980575796 0.000113186789991416 NA NA NA hsa-miR-34c-5p DUSP8 2.20632574870337 0.000379662996168678 -0.377360083984294 0.301632819949477 MirTarget -0.162327960442448 7.54873326640233e-05 NA NA NA hsa-miR-3922-3p DUSP8 1.33252322927569 0.000665307190249975 -0.377360083984294 0.301632819949477 mirMAP -0.25966659594857 0.000604151318506519 NA NA NA hsa-miR-452-3p DUSP8 2.2028815467959 0.00185370432491004 -0.377360083984294 0.301632819949477 mirMAP -0.171451736412772 2.12455295373032e-05 NA NA NA hsa-let-7g-5p DUSP9 0.325297685027927 0.241142963826631 3.82388601052388 6.68829234319894e-05 miRNATAP -1.0437632124536 2.97596326485716e-05 NA NA NA hsa-miR-194-5p DUSP9 -0.127742909829168 0.906065815804667 3.82388601052388 6.68829234319894e-05 MirTarget;miRNATAP -0.541693564467761 1.02827578277526e-20 NA NA NA hsa-miR-30d-3p DUSP9 -0.545113326540761 0.0433733076874155 3.82388601052388 6.68829234319894e-05 MirTarget -1.17137043336668 4.44756547669925e-06 NA NA NA hsa-miR-338-3p DUSP9 -0.959276231066179 0.0191473351014091 3.82388601052388 6.68829234319894e-05 mirMAP -0.923706470644292 1.82404506389244e-08 NA NA NA hsa-miR-361-3p DUSP9 -0.126462931388735 0.566052688733137 3.82388601052388 6.68829234319894e-05 mirMAP -1.05159514570064 0.00105070129127604 NA NA NA hsa-miR-362-3p DUSP9 -0.0349414695893027 0.913780708043777 3.82388601052388 6.68829234319894e-05 miRNATAP -0.643712681131283 0.00307812790256381 NA NA NA hsa-miR-107 EGFR 0.904627575346218 4.67936495073904e-05 0.168405729171091 0.73751794453199 miRanda -0.780624524284184 6.54393495762893e-07 NA NA NA hsa-miR-126-5p EGFR 0.41765430251855 0.0753161203651532 0.168405729171091 0.73751794453199 mirMAP -0.430024627428674 0.00524917462605061 NA NA NA hsa-miR-140-5p EGFR 0.208193069681326 0.303002433893804 0.168405729171091 0.73751794453199 miRanda -0.643161622365357 0.00034542548755441 NA NA NA hsa-miR-146a-5p EGFR 1.82051649415508 2.03651725047679e-05 0.168405729171091 0.73751794453199 miRNAWalker2_validate -0.280474680543866 0.000569416646908149 25242818;22161865;25596948;24895573;25417703;23555954;24839931;21632853 Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;MiR 146a suppresses tumor growth and progression by targeting EGFR pathway and in a p ERK dependent manner in castration resistant prostate cancer; Mechanistic studies revealed that miR-146a repressed the expression of EGFR through binding to its 3'-untranslated region; Our findings suggest that ubiquitous loss of miR-146a is a critical mechanism for overexpression of EGFR in CRPC which is crucial to better understanding the pathogenesis of CRPC;Furthermore the expressions of bax and cleaved-caspase-3 mainly were increased in control and overexpression miR-146a groups however the expression of EGFR was inverse; All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells which was performed by up-regulating miR-146a expression then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways and inhibiting invasion through down-regulating the expression of EGFR;Furthermore western blot showed that miR-146a mimic downregulated EGFR ERK1/2 and stat5 signalings; These effects were less potent compared to that of a siRNA targeting EGFR a known target gene of miR-146a; Moreover miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents;Here we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a; We show that BRCA1 binds to MIR146A promoter and activates transcription which in turn attenuates EGFR expression;In functional experiments miR-146a suppressed cell growth induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines H358 H1650 H1975 HCC827 and H292 miR-146a also inhibited the migratory capacity of these NSCLC cells; On the other hand miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR including both TKIs gefitinib erlotinib and afatinib and a monoclonal antibody cetuximab; Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling;Deregulation of miR 146a expression in a mouse model of pancreatic cancer affecting EGFR signaling; Treatment of PC cells with CDF a novel synthetic compound led to re-expression of miR-146a resulting in the down-regulation of EGFR expression; Further knock-down of miR-146a in AsPC-1 cells led to the up-regulation of EGFR expression and showed increased clonogenic growth; In addition knock-down of EGFR by EGFR siRNA transfection of parental AsPC-1 cells and AsPC-1 cells stably transfected with pre-miR-146a resulted in decreased invasive capacity which was further confirmed by reduced luciferase activity in cells transfected with pMIR-Luc reporter vector containing miR-146a binding site; Collectively these results suggest that the loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling and that re-expression of miR-146a by CDF treatment could be useful in designing personalized strategy for the treatment of human PC;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;progression;;;;;; pancreatic cancer;prostate cancer;breast cancer;liver cancer;breast cancer;lung squamous cell cancer;pancreatic cancer;gastric cancer hsa-miR-186-5p EGFR 0.149964130725901 0.434709542998771 0.168405729171091 0.73751794453199 mirMAP -0.543315983386011 0.00447337739548099 NA NA NA hsa-miR-188-5p EGFR 1.35426907033843 0.00038346077691455 0.168405729171091 0.73751794453199 mirMAP -0.351646013165135 0.000124637708877987 NA NA NA hsa-miR-192-3p EGFR 0.355565421687399 0.74117031340037 0.168405729171091 0.73751794453199 mirMAP -0.206727639222232 1.36090223856721e-10 NA NA NA hsa-miR-192-5p EGFR 0.0809146624034405 0.941057093528709 0.168405729171091 0.73751794453199 mirMAP -0.226019181220992 1.67449171990161e-13 NA NA NA hsa-miR-194-3p EGFR 0.259420201261466 0.821811295418686 0.168405729171091 0.73751794453199 MirTarget -0.203898575114252 6.68731990591179e-12 NA NA NA hsa-miR-200a-3p EGFR 0.717826667295984 0.193912116506827 0.168405729171091 0.73751794453199 MirTarget -0.169331211945448 0.00867601958667097 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-29b-2-5p EGFR -1.7015307882027 2.84239251703401e-10 0.168405729171091 0.73751794453199 mirMAP -0.3910017356137 0.00207778215894223 NA NA NA hsa-miR-30d-3p EGFR -0.545113326540761 0.0433733076874155 0.168405729171091 0.73751794453199 mirMAP -0.407148961073724 0.00219111229801308 NA NA NA hsa-miR-320b EGFR 1.11183660885284 0.000497971211648503 0.168405729171091 0.73751794453199 miRanda;mirMAP -0.332140716516881 0.0026979597411761 NA NA NA hsa-miR-335-5p EGFR 1.59953351087307 5.56170899867314e-05 0.168405729171091 0.73751794453199 miRNAWalker2_validate -0.398979814842028 4.4125849451091e-06 NA NA NA hsa-miR-340-5p EGFR -0.164941927483643 0.529910509321278 0.168405729171091 0.73751794453199 mirMAP -0.501426550811941 0.000243508571779912 NA NA NA hsa-miR-362-5p EGFR -0.354508685915981 0.354912078595613 0.168405729171091 0.73751794453199 mirMAP -0.432765239197852 2.36063976575942e-06 NA NA NA hsa-miR-375 EGFR -2.94506033785642 0.00570147601654791 0.168405729171091 0.73751794453199 miRanda -0.189586479112383 2.94006132397572e-09 NA NA NA hsa-miR-378c EGFR -1.27752074861415 2.73676010235611e-05 0.168405729171091 0.73751794453199 mirMAP -0.494126324357503 1.44640511557456e-05 NA NA NA hsa-miR-501-5p EGFR 0.266919328110625 0.454779001968586 0.168405729171091 0.73751794453199 mirMAP -0.499445439422852 3.55760656495929e-07 NA NA NA hsa-miR-577 EGFR 0.911619788986754 0.2256062124148 0.168405729171091 0.73751794453199 mirMAP -0.181043665182683 0.000164650893742774 NA NA NA hsa-miR-7-1-3p EGFR 0.709309110750947 0.0412301737463194 0.168405729171091 0.73751794453199 mirMAP -0.453112022139855 7.47168008914619e-06 NA NA NA hsa-miR-7-5p EGFR 1.63575693499363 0.0124424214624534 0.168405729171091 0.73751794453199 miRNAWalker2_validate;miRTarBase;MirTarget -0.267933940433673 1.42488777071465e-06 26708917;23115635;25503932;21712475;25334070;25532106;27203220;25862909;24816687;20978205;24603851;24573489;25289099;23227519 In addition the experimental data also suggest that miR-7 can interfere with EGFR mRNA translation; In addition miR-7 may function by interfering with EGFR mRNA translation but not degradation;Several studies have demonstrated that microRNA-7 miR-7 regulates EGFR expression and Akt activity in a range of cancer cell types via its specific interaction with the EGFR mRNA 3'-untranslated region 3'-UTR; Together these data support the coordinate regulation of Akt signaling by miR-7 in HNC cells and suggest the therapeutic potential of miR-7 alone or in combination with EGFR TKIs in this disease;The potential for miR-7 to act as a tumor suppressor by coordinately regulating the epidermal growth factor receptor EGFR signaling pathway at several levels was examined; We investigated the tumor inhibitory effect of miR-7 in CRC with particular focus on the relationship between miR-7 and the EGFR pathway; The regulation of EGFR by miR-7 was examined with miR-7 precursor-transfected cells; Furthermore we investigated whether miR-7 suppresses proliferation of CRC cells in combination with cetuximab a monoclonal antibody against EGFR; In vitro assays showed that EGFR and RAF-1 are direct targets of miR-7 which potently suppressed the proliferation of CRC cells and interestingly that the growth inhibitory effect of each of these was enhanced by cetuximab;To overcome the resistance we focused on EGFR suppression using microRNA-7 miR-7 targeting multiple sites in the 3'-untranslated region of EGFR mRNA;Furthermore inhibition of EGFR showed similar effects to miR-7 enforcement in 3LL cells; Taken together these findings revealed that miR-7 acts as an antitumor miRNA in 3LL by targeting and suppressing the expression of both EGFR and RAF-1 oncogenes;MiR-7 inhibited MCF-7/HER2Δ16 cell migration through a mechanism involving suppression of the miR-7 target gene EGFR; In contrast miR-7 inhibition of MCF-7/HER2Δ16 cell proliferation involved a pathway where miR-7 expression resulted in the inactivation of Src kinase independent of suppressed EGFR expression; Also independent of EGFR suppression reestablished miR-7 expression sensitized refractory MCF-7/HER2Δ16 cells to trastuzumab; We propose that miR-7 regulated pathways including EGFR and Src kinase represent targets for the therapeutic intervention of refractory and metastatic HER2Δ16 driven breast cancer;microRNA-7-5p miR-7-5p is a tumor suppressor in multiple cancer types and inhibits growth and invasion by suppressing expression and activity of the epidermal growth factor receptor EGFR signaling pathway;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;In recent years mounting evidence indicates that EGFR is a direct and functional target of miR-7; In this study we found that miR-7 expression was significantly downregulated in highly metastatic epithelial ovarian cancer EOC cell lines and metastatic tissues whereas the expression of EGFR correlated positively with metastasis in both EOC patients and cell lines; Finally the expression of miR-7 and EGFR in primary EOC with matched metastasis tissues was explored; It was showed that miR-7 is inversely correlated with EGFR; Taken together our results suggested that miR-7 inhibited tumor metastasis and reversed EMT through AKT and ERK1/2 pathway inactivation by reducing EGFR expression in EOC cell lines;In this study we report the discovery and mechanistic characterization of the miRNA miR-7 as an oncogenic "oncomiR" and its role as a key mediator of EGFR signaling in lung cancer cells;We show that microRNA-7 miR-7 is a common regulator of the phosphoinositide-3-kinase PI3K/ATK and Raf/mitogen-activated protein kinase kinase MEK/extracellular signal-regulated kinase ERK pathways both of which are launched by EGFR through its two direct targets the transcription factors PI3K and Raf-1 respectively; We conclude that miR-7 is a potential tumor suppressor in glioblastoma that acts by targeting multiple oncogenes related to the downstream pathway of EGFR and may serve as a novel therapeutic target for malignant gliomas;Further study will investigate miR-7 in the regulation of EGFR expression in vitro and in vivo;Pretreatment of miR-7 mimics enhanced the PTX-mediated downregulation of epidermal growth factor receptor EGFR in NSCLC cells;We identified miR-7 as the important miRNA associated with estrogen actions in these cells and further examined the changes of estrogen-dependent EGFR expression by miR-7 in ER-positive or -negative breast carcinoma cell lines including MCF-7; We also evaluated the correlation between miR-7 and EGFR expression in breast carcinoma cells derived from 21 patients using laser capture microdissection combined with quantitative reverse transcriptase-PCR; miR-7 was reported to suppress epidermal growth factor receptor EGFR expression in several human malignancies; Transfection of miR-7 significantly suppressed EGFR mRNA levels in MCF-7 cells; We also evaluated the status of miR-7 in breast carcinoma tissues but the correlation between the status of miR-7 and EGFR in carcinoma cells isolated by laser capture microscopy was not detected; These results suggest that miR-7 may play a role in the development of resistance to endocrine therapy in breast cancer patients through regulating EGFR expression of carcinoma cells ;;;drug resistance;;cell migration;;;metastasis;;malignant trasformation;;;drug resistance esophageal cancer;head and neck cancer;colorectal cancer;lung cancer;lung cancer;breast cancer;melanoma;ovarian cancer;ovarian cancer;lung cancer;glioblastoma;gastric cancer;lung squamous cell cancer;breast cancer hsa-miR-877-5p EGFR 2.17859965442336 1.03593450648516e-07 0.168405729171091 0.73751794453199 mirMAP -0.228987457354068 0.00665763782285166 NA NA NA hsa-miR-106a-5p FAS -0.173255688252641 0.642872703263671 0.657268335933371 0.0207009292820455 miRNAWalker2_validate;miRTarBase -0.15547134509945 0.00429149494899305 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-129-5p FAS -2.56914016541176 2.36237896095709e-06 0.657268335933371 0.0207009292820455 miRanda -0.124419506861282 0.000695154070004086 NA NA NA hsa-miR-92b-3p FASLG 1.33518446513417 1.45350885391576e-06 0.493896235569131 0.390001245956277 miRNATAP -0.542744180708012 0.000155394781632395 NA NA NA hsa-miR-126-5p FGF1 0.41765430251855 0.0753161203651532 -0.160234396361762 0.733972871379557 mirMAP -0.59094523029959 3.50264864833946e-05 NA NA NA hsa-miR-16-1-3p FGF1 1.43227522002564 3.70920454953168e-08 -0.160234396361762 0.733972871379557 mirMAP -0.415017127195873 0.000891606226757529 NA NA NA hsa-miR-186-5p FGF1 0.149964130725901 0.434709542998771 -0.160234396361762 0.733972871379557 mirMAP -0.802927092384163 5.33712623622096e-06 NA NA NA hsa-miR-18a-5p FGF1 2.20211504140984 1.78678887916334e-09 -0.160234396361762 0.733972871379557 MirTarget -0.427564859159038 6.45322365688328e-07 NA NA NA hsa-miR-222-5p FGF1 1.87968474330782 1.11743009485711e-06 -0.160234396361762 0.733972871379557 MirTarget -0.328069555060374 8.83297301332189e-05 NA NA NA hsa-miR-26b-3p FGF1 -0.0103961389461977 0.965770899625511 -0.160234396361762 0.733972871379557 MirTarget -0.614591765464955 8.91145535430066e-06 NA NA NA hsa-miR-29a-5p FGF1 0.585084040404152 0.023014129158495 -0.160234396361762 0.733972871379557 mirMAP -0.604881337368894 2.58167935202965e-06 NA NA NA hsa-miR-320a FGF1 0.593888711838028 0.011897419390526 -0.160234396361762 0.733972871379557 miRanda -0.386072945122806 0.00701900096114403 NA NA NA hsa-miR-320b FGF1 1.11183660885284 0.000497971211648503 -0.160234396361762 0.733972871379557 miRanda -0.368173004233106 0.000368398615653149 NA NA NA hsa-miR-326 FGF1 -0.429748586406214 0.2629894124021 -0.160234396361762 0.733972871379557 miRanda;miRNATAP -0.385294600510288 9.62075997895276e-06 NA NA NA hsa-miR-330-5p FGF1 0.488365986827708 0.0512207630808233 -0.160234396361762 0.733972871379557 miRanda;miRNATAP -0.490680892266321 0.000251789498451697 NA NA NA hsa-miR-429 FGF1 1.40182602301928 0.00900426780286475 -0.160234396361762 0.733972871379557 miRNATAP -0.323262102446773 7.92592247701929e-08 NA NA NA hsa-miR-484 FGF1 0.71327898984355 0.00233605130771196 -0.160234396361762 0.733972871379557 MirTarget;PITA;miRNATAP -0.408471643921956 0.00445789085377771 NA NA NA hsa-miR-532-3p FGF1 0.552364451472481 0.0975490365586023 -0.160234396361762 0.733972871379557 miRNATAP -0.744864947914853 2.30927245315596e-15 NA NA NA hsa-miR-550a-5p FGF1 2.27360629906903 2.14504977831873e-07 -0.160234396361762 0.733972871379557 MirTarget -0.412011719251591 1.06463288268876e-08 NA NA NA hsa-miR-590-5p FGF1 1.04171442093217 0.000272475544954865 -0.160234396361762 0.733972871379557 MirTarget;miRanda;miRNATAP -0.411316166846436 0.00036918107931291 NA NA NA hsa-miR-625-5p FGF1 0.537211086526376 0.203801009380384 -0.160234396361762 0.733972871379557 MirTarget -0.597908728237488 7.37909450819918e-16 NA NA NA hsa-miR-629-5p FGF1 1.06377074768516 0.000536624707722274 -0.160234396361762 0.733972871379557 MirTarget -0.349957209459157 0.00121021361741485 NA NA NA hsa-miR-7-5p FGF1 1.63575693499363 0.0124424214624534 -0.160234396361762 0.733972871379557 miRNAWalker2_validate -0.334571255736156 4.63756500683767e-11 NA NA NA hsa-let-7f-5p FGF11 0.634633924115866 0.0344982923411787 1.34606246397032 0.0313874796480627 mirMAP;miRNATAP -0.594039289750789 5.85711011149972e-05 NA NA NA hsa-let-7g-5p FGF11 0.325297685027927 0.241142963826631 1.34606246397032 0.0313874796480627 mirMAP;miRNATAP -0.875110015083308 3.01548567374744e-08 NA NA NA hsa-miR-10a-5p FGF11 -0.470861534765518 0.148803248989189 1.34606246397032 0.0313874796480627 mirMAP -0.839577254558606 2.06461410522248e-10 NA NA NA hsa-miR-217 FGF11 -0.0121404731225336 0.980818372851502 1.34606246397032 0.0313874796480627 PITA;miRanda -0.251553843688479 0.00449992982096522 NA NA NA hsa-miR-326 FGF11 -0.429748586406214 0.2629894124021 1.34606246397032 0.0313874796480627 MirTarget;PITA;miRanda;miRNATAP -0.444845744428783 0.000143421345045733 NA NA NA hsa-miR-335-5p FGF11 1.59953351087307 5.56170899867314e-05 1.34606246397032 0.0313874796480627 miRNAWalker2_validate;mirMAP -0.384291765399063 0.000482054927218443 NA NA NA hsa-miR-532-3p FGF11 0.552364451472481 0.0975490365586023 1.34606246397032 0.0313874796480627 mirMAP -0.60511003013694 4.75511871948254e-06 NA NA NA hsa-let-7f-1-3p FGF12 1.28704406797397 1.17954701106157e-06 -0.587357499262027 0.310516155638288 MirTarget -0.500961231356776 0.000998540142849314 NA NA NA hsa-miR-29a-5p FGF12 0.585084040404152 0.023014129158495 -0.587357499262027 0.310516155638288 MirTarget -0.561752160653773 0.000457570295243942 NA NA NA hsa-let-7f-1-3p FGF13 1.28704406797397 1.17954701106157e-06 -2.34574028365922 0.000183807352189951 MirTarget -0.563169375210783 0.000773915454703851 NA NA NA hsa-miR-141-3p FGF13 1.45548825076434 0.00115958850961764 -2.34574028365922 0.000183807352189951 TargetScan -0.419319186157982 2.18410603313764e-05 NA NA NA hsa-miR-200a-5p FGF13 1.50371809098978 0.00263602434344863 -2.34574028365922 0.000183807352189951 MirTarget;miRNATAP -0.316435602783381 0.000388466610194628 NA NA NA hsa-miR-200b-5p FGF13 0.969871521250413 0.0530500454130183 -2.34574028365922 0.000183807352189951 MirTarget -0.346419909837961 0.000222834092725641 NA NA NA hsa-miR-31-3p FGF13 0.474904754927656 0.506866261575484 -2.34574028365922 0.000183807352189951 miRNATAP -0.216224775700072 0.000656063150041637 NA NA NA hsa-miR-3682-3p FGF13 1.96838261925327 4.94885331227292e-06 -2.34574028365922 0.000183807352189951 MirTarget -0.406979633607707 0.000829055016383721 NA NA NA hsa-miR-429 FGF13 1.40182602301928 0.00900426780286475 -2.34574028365922 0.000183807352189951 miRNATAP -0.296325455439465 0.000372916450321645 NA NA NA hsa-miR-455-5p FGF13 1.20462751989145 6.74386011867484e-05 -2.34574028365922 0.000183807352189951 PITA;miRanda -0.492592516788581 0.000853952308418692 NA NA NA hsa-miR-590-3p FGF13 1.11654983899947 0.000160782154924864 -2.34574028365922 0.000183807352189951 miRanda -0.496872134281738 0.00103030244047749 NA NA NA hsa-miR-7-1-3p FGF13 0.709309110750947 0.0412301737463194 -2.34574028365922 0.000183807352189951 MirTarget;mirMAP -0.473759888075165 0.000258502260079092 NA NA NA hsa-miR-421 FGF14 1.80720854070385 1.59709651202848e-07 -2.26824495321978 0.000644201162802339 miRanda -0.51290819363414 0.000127157329894553 NA NA NA hsa-miR-590-3p FGF14 1.11654983899947 0.000160782154924864 -2.26824495321978 0.000644201162802339 miRanda -0.775153716412423 8.24216834793137e-07 NA NA NA hsa-miR-96-5p FGF14 1.14243043653372 0.00942969392739105 -2.26824495321978 0.000644201162802339 TargetScan -0.326435839133923 0.00402772700697129 NA NA NA hsa-miR-16-5p FGF18 1.00515772948091 5.33912942007619e-06 -0.701320708357095 0.262070500539484 miRNATAP -0.544910968247721 0.00650462011718626 NA NA NA hsa-miR-424-5p FGF18 1.08509868581983 0.000420473853818268 -0.701320708357095 0.262070500539484 miRNATAP -0.446614957034455 0.0018153474746596 NA NA NA hsa-miR-590-5p FGF18 1.04171442093217 0.000272475544954865 -0.701320708357095 0.262070500539484 miRanda;miRNATAP -0.766369227739518 3.8382097156196e-07 NA NA NA hsa-miR-9-5p FGF18 -0.195328736653048 0.761470692992178 -0.701320708357095 0.262070500539484 miRNATAP -0.237173048014931 0.000555869006551748 NA NA NA hsa-let-7a-3p FGF2 0.503048155002889 0.0411145454335299 -1.87861117290298 0.000125445679104344 mirMAP -0.410539117311516 0.00473622063740347 NA NA NA hsa-let-7b-3p FGF2 0.21838629112113 0.296038413622566 -1.87861117290298 0.000125445679104344 mirMAP -0.469514467711896 0.00680853109557966 NA NA NA hsa-let-7f-1-3p FGF2 1.28704406797397 1.17954701106157e-06 -1.87861117290298 0.000125445679104344 mirMAP -0.595048658334427 4.14210020217409e-06 NA NA NA hsa-miR-103a-3p FGF2 0.840525139266028 5.83536475789158e-07 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate;MirTarget;miRNATAP -0.939824662070765 6.5144907085955e-06 NA NA NA hsa-miR-107 FGF2 0.904627575346218 4.67936495073904e-05 -1.87861117290298 0.000125445679104344 MirTarget;PITA;miRanda;miRNATAP -0.633691610533513 5.77496353910729e-05 NA NA NA hsa-miR-15a-5p FGF2 1.03783090449383 7.40334108980898e-07 -1.87861117290298 0.000125445679104344 MirTarget;miRNATAP -0.723624902429406 1.17476403328068e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 1.75738933306437 3.00554466232543e-08 -1.87861117290298 0.000125445679104344 mirMAP -0.601578664515957 9.71241978321172e-09 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 1.62046407540723 5.42152621571078e-09 -1.87861117290298 0.000125445679104344 MirTarget;miRNATAP -0.727556694335382 9.63850854162267e-10 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 1.43227522002564 3.70920454953168e-08 -1.87861117290298 0.000125445679104344 mirMAP -0.533569195692814 4.82742810832383e-05 NA NA NA hsa-miR-16-2-3p FGF2 1.8048179609245 2.83095715136409e-09 -1.87861117290298 0.000125445679104344 mirMAP -0.582691850054445 1.0626071080659e-07 NA NA NA hsa-miR-16-5p FGF2 1.00515772948091 5.33912942007619e-06 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate;MirTarget;miRNATAP -0.87728356493459 1.36815119437221e-08 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-186-5p FGF2 0.149964130725901 0.434709542998771 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate;mirMAP -0.536525732490695 0.00470973709226905 NA NA NA hsa-miR-192-5p FGF2 0.0809146624034405 0.941057093528709 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate -0.100431705795905 0.00182203175890127 NA NA NA hsa-miR-19b-1-5p FGF2 1.38738648038895 1.3113681938066e-06 -1.87861117290298 0.000125445679104344 mirMAP -0.540056441979374 5.90790389026898e-06 NA NA NA hsa-miR-200b-3p FGF2 0.974577911407732 0.0595020056914543 -1.87861117290298 0.000125445679104344 mirMAP -0.35358155461024 1.0502797949384e-07 NA NA NA hsa-miR-200c-3p FGF2 1.28185685499076 0.00369777635539177 -1.87861117290298 0.000125445679104344 mirMAP -0.459255722541169 2.21550497680624e-09 NA NA NA hsa-miR-20a-3p FGF2 1.13957127410163 0.000451087640268489 -1.87861117290298 0.000125445679104344 mirMAP -0.635980126804227 1.03782626210616e-09 NA NA NA hsa-miR-21-3p FGF2 1.75245546017565 2.36505176715025e-10 -1.87861117290298 0.000125445679104344 mirMAP -0.541952936598777 7.7895313994942e-06 NA NA NA hsa-miR-21-5p FGF2 1.75445050487988 2.41825549682022e-23 -1.87861117290298 0.000125445679104344 mirMAP -0.484524479326667 0.00821705219155879 NA NA NA hsa-miR-215-5p FGF2 0.715250240418615 0.573784317311889 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate -0.104771518281948 0.000141751804794456 NA NA NA hsa-miR-221-3p FGF2 1.33496247538338 3.82022531235275e-07 -1.87861117290298 0.000125445679104344 mirMAP -0.544428779797939 3.02629502512127e-05 NA NA NA hsa-miR-222-3p FGF2 1.39382731585819 9.98182478024671e-07 -1.87861117290298 0.000125445679104344 mirMAP -0.541204112402845 6.44319127167856e-06 NA NA NA hsa-miR-29a-5p FGF2 0.585084040404152 0.023014129158495 -1.87861117290298 0.000125445679104344 mirMAP -0.424035558508381 0.00219032018724374 NA NA NA hsa-miR-330-3p FGF2 0.798460296022179 0.00746538156533435 -1.87861117290298 0.000125445679104344 mirMAP -0.498128953238189 2.14033471411407e-05 NA NA NA hsa-miR-335-3p FGF2 2.5197689063267 2.20084506976733e-09 -1.87861117290298 0.000125445679104344 mirMAP -0.417269866841731 1.09046144483422e-07 NA NA NA hsa-miR-335-5p FGF2 1.59953351087307 5.56170899867314e-05 -1.87861117290298 0.000125445679104344 miRNATAP -0.323054850441658 0.000208841445593432 NA NA NA hsa-miR-3662 FGF2 1.82780708047676 0.0054036501346178 -1.87861117290298 0.000125445679104344 mirMAP -0.212606715986015 0.00207695589115596 NA NA NA hsa-miR-3682-3p FGF2 1.96838261925327 4.94885331227292e-06 -1.87861117290298 0.000125445679104344 mirMAP -0.621299624827262 8.40451860827003e-12 NA NA NA hsa-miR-424-5p FGF2 1.08509868581983 0.000420473853818268 -1.87861117290298 0.000125445679104344 MirTarget;miRNATAP -0.473116310929624 2.79114365346124e-05 NA NA NA hsa-miR-429 FGF2 1.40182602301928 0.00900426780286475 -1.87861117290298 0.000125445679104344 mirMAP -0.389653476745427 6.14878920514716e-10 NA NA NA hsa-miR-503-5p FGF2 1.88558728489534 2.26317868368257e-06 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate -0.328905971783003 0.000129296346907329 NA NA NA hsa-miR-577 FGF2 0.911619788986754 0.2256062124148 -1.87861117290298 0.000125445679104344 mirMAP -0.189066289658318 7.18727306857422e-05 NA NA NA hsa-miR-589-3p FGF2 1.01962606923682 0.00577853347252709 -1.87861117290298 0.000125445679104344 mirMAP -0.306084948128741 0.00129523811230291 NA NA NA hsa-miR-590-3p FGF2 1.11654983899947 0.000160782154924864 -1.87861117290298 0.000125445679104344 miRanda;mirMAP -0.502156114781839 1.81367444334514e-05 NA NA NA hsa-miR-590-5p FGF2 1.04171442093217 0.000272475544954865 -1.87861117290298 0.000125445679104344 miRanda;mirMAP -0.698076507895779 4.36148419548274e-09 NA NA NA hsa-miR-92a-3p FGF2 1.2209325870225 6.8757197708107e-06 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate -0.711959382156384 1.14570619492506e-08 NA NA NA hsa-miR-93-3p FGF2 1.88964231421793 1.80075645722786e-08 -1.87861117290298 0.000125445679104344 mirMAP -0.494286067593777 7.56548629194091e-07 NA NA NA hsa-miR-126-5p FGF5 0.41765430251855 0.0753161203651532 -0.112737413770707 0.889018159422693 mirMAP -1.27299674044633 1.36904003609118e-07 NA NA NA hsa-miR-15b-5p FGF5 1.62046407540723 5.42152621571078e-09 -0.112737413770707 0.889018159422693 miRNAWalker2_validate -0.628499833905292 0.00163763954361993 NA NA NA hsa-miR-16-1-3p FGF5 1.43227522002564 3.70920454953168e-08 -0.112737413770707 0.889018159422693 mirMAP -0.598397522653231 0.00540255809360042 NA NA NA hsa-miR-30b-5p FGF5 -0.430720743745757 0.0593564057320791 -0.112737413770707 0.889018159422693 mirMAP -1.09663962120345 1.27869374681852e-05 NA NA NA hsa-miR-30d-5p FGF5 -0.5492586056147 0.0140125082460125 -0.112737413770707 0.889018159422693 mirMAP -1.26603557046881 6.44034616744386e-07 NA NA NA hsa-miR-32-3p FGF5 0.583525764322974 0.11837203008551 -0.112737413770707 0.889018159422693 mirMAP -0.718233961496998 2.69211257467585e-05 NA NA NA hsa-miR-335-3p FGF5 2.5197689063267 2.20084506976733e-09 -0.112737413770707 0.889018159422693 mirMAP -0.482052236534025 0.00020013696125674 NA NA NA hsa-miR-338-3p FGF5 -0.959276231066179 0.0191473351014091 -0.112737413770707 0.889018159422693 miRanda -0.6177985816089 6.96794360953983e-06 NA NA NA hsa-miR-33a-3p FGF5 0.347011402017138 0.321709379745392 -0.112737413770707 0.889018159422693 mirMAP -0.576535909647833 0.000837306247871141 NA NA NA hsa-miR-500a-5p FGF5 0.00337014556047865 0.992120109131868 -0.112737413770707 0.889018159422693 mirMAP -0.614477528187278 0.000256513680663112 NA NA NA hsa-miR-501-5p FGF5 0.266919328110625 0.454779001968586 -0.112737413770707 0.889018159422693 PITA;mirMAP -0.62614984876482 9.06674208094652e-05 NA NA NA hsa-miR-577 FGF5 0.911619788986754 0.2256062124148 -0.112737413770707 0.889018159422693 miRNATAP -0.444405147807268 3.59000876753453e-09 NA NA NA hsa-miR-590-3p FGF5 1.11654983899947 0.000160782154924864 -0.112737413770707 0.889018159422693 miRanda;mirMAP;miRNATAP -0.612555222447379 0.00140100895653425 NA NA NA hsa-miR-7-1-3p FGF5 0.709309110750947 0.0412301737463194 -0.112737413770707 0.889018159422693 mirMAP -0.869207993564472 6.50749322750585e-08 NA NA NA hsa-let-7a-3p FGF7 0.503048155002889 0.0411145454335299 -1.5602156825587 0.00498637377963977 MirTarget;miRNATAP -0.731037360749972 5.50569814204452e-06 NA NA NA hsa-let-7b-3p FGF7 0.21838629112113 0.296038413622566 -1.5602156825587 0.00498637377963977 MirTarget;miRNATAP -0.741810215119105 0.000124390628283528 NA NA NA hsa-let-7f-1-3p FGF7 1.28704406797397 1.17954701106157e-06 -1.5602156825587 0.00498637377963977 MirTarget -0.619496528449976 2.19591491777331e-05 NA NA NA hsa-miR-107 FGF7 0.904627575346218 4.67936495073904e-05 -1.5602156825587 0.00498637377963977 PITA;miRanda;miRNATAP -0.777246028518609 1.06521367448641e-05 NA NA NA hsa-miR-15a-5p FGF7 1.03783090449383 7.40334108980898e-07 -1.5602156825587 0.00498637377963977 miRTarBase;miRNATAP -1.03381303077926 1.53980295049369e-08 NA NA NA hsa-miR-15b-5p FGF7 1.62046407540723 5.42152621571078e-09 -1.5602156825587 0.00498637377963977 miRNATAP -1.10853915197794 3.91159333945632e-18 NA NA NA hsa-miR-16-1-3p FGF7 1.43227522002564 3.70920454953168e-08 -1.5602156825587 0.00498637377963977 mirMAP -0.828766285961256 1.00941095464602e-08 NA NA NA hsa-miR-16-2-3p FGF7 1.8048179609245 2.83095715136409e-09 -1.5602156825587 0.00498637377963977 mirMAP -0.894500676245952 5.67629159494697e-14 NA NA NA hsa-miR-16-5p FGF7 1.00515772948091 5.33912942007619e-06 -1.5602156825587 0.00498637377963977 miRNATAP -1.4084082340258 1.61565851852723e-17 NA NA NA hsa-miR-18a-3p FGF7 2.35188582849667 1.39401350286321e-08 -1.5602156825587 0.00498637377963977 MirTarget -0.60538245987518 7.27850574065591e-12 NA NA NA hsa-miR-20a-5p FGF7 1.4503375861709 5.7813456424762e-07 -1.5602156825587 0.00498637377963977 miRNAWalker2_validate -0.815425734145646 2.61657869983007e-10 NA NA NA hsa-miR-26b-5p FGF7 -0.301646326928219 0.160081421968103 -1.5602156825587 0.00498637377963977 mirMAP -0.573628684843975 0.0024027834337405 NA NA NA hsa-miR-27a-3p FGF7 1.29886998470345 2.68986118553486e-08 -1.5602156825587 0.00498637377963977 MirTarget -0.784712509256695 1.6375276114047e-06 NA NA NA hsa-miR-31-5p FGF7 0.666358292391859 0.381800494600846 -1.5602156825587 0.00498637377963977 MirTarget -0.286141542958258 9.31592868791215e-08 NA NA NA hsa-miR-320a FGF7 0.593888711838028 0.011897419390526 -1.5602156825587 0.00498637377963977 miRanda -0.501509634690982 0.00321500749912934 NA NA NA hsa-miR-320b FGF7 1.11183660885284 0.000497971211648503 -1.5602156825587 0.00498637377963977 miRanda -0.602963126908309 6.53118857584566e-07 NA NA NA hsa-miR-33a-3p FGF7 0.347011402017138 0.321709379745392 -1.5602156825587 0.00498637377963977 mirMAP -0.714323468107036 6.96759113987999e-10 NA NA NA hsa-miR-361-5p FGF7 0.407725414130987 0.0181260969156347 -1.5602156825587 0.00498637377963977 PITA;miRanda;miRNATAP -1.05023708199515 7.33408072452573e-06 NA NA NA hsa-miR-3662 FGF7 1.82780708047676 0.0054036501346178 -1.5602156825587 0.00498637377963977 MirTarget;mirMAP;miRNATAP -0.343246402685412 7.47671778480477e-06 NA NA NA hsa-miR-421 FGF7 1.80720854070385 1.59709651202848e-07 -1.5602156825587 0.00498637377963977 miRanda -0.472997333251649 1.97004361691138e-05 NA NA NA hsa-miR-424-5p FGF7 1.08509868581983 0.000420473853818268 -1.5602156825587 0.00498637377963977 miRNATAP -0.685297094218223 4.20996402527186e-08 NA NA NA hsa-miR-429 FGF7 1.40182602301928 0.00900426780286475 -1.5602156825587 0.00498637377963977 miRNATAP -0.402624994165276 1.7337446619432e-08 NA NA NA hsa-miR-452-5p FGF7 2.08756506185889 0.000258095769002813 -1.5602156825587 0.00498637377963977 mirMAP -0.269324797275113 7.28201796410245e-05 NA NA NA hsa-miR-455-3p FGF7 2.29532323519288 1.85675588946527e-07 -1.5602156825587 0.00498637377963977 PITA;miRNATAP -0.699538843370974 3.81324365803807e-18 NA NA NA hsa-miR-484 FGF7 0.71327898984355 0.00233605130771196 -1.5602156825587 0.00498637377963977 PITA -0.917837472299362 3.34732094641496e-08 NA NA NA hsa-miR-486-5p FGF7 -0.627607241830911 0.155274583521138 -1.5602156825587 0.00498637377963977 MirTarget;miRanda -0.269041213010616 0.00282702512889706 NA NA NA hsa-miR-542-3p FGF7 0.757649022262991 0.00210575463285599 -1.5602156825587 0.00498637377963977 miRanda -0.575428372905158 0.000361082468087173 NA NA NA hsa-miR-577 FGF7 0.911619788986754 0.2256062124148 -1.5602156825587 0.00498637377963977 PITA;mirMAP -0.260587392511629 8.78612250385762e-07 NA NA NA hsa-miR-582-3p FGF7 -0.412897415951272 0.202939245403793 -1.5602156825587 0.00498637377963977 PITA;miRNATAP -0.478173140136422 9.36091921722173e-05 NA NA NA hsa-miR-590-3p FGF7 1.11654983899947 0.000160782154924864 -1.5602156825587 0.00498637377963977 PITA;miRanda;mirMAP;miRNATAP -0.672431604720525 2.51151561650779e-07 NA NA NA hsa-miR-590-5p FGF7 1.04171442093217 0.000272475544954865 -1.5602156825587 0.00498637377963977 PITA;miRanda -0.997192552428985 1.50828670699697e-14 NA NA NA hsa-miR-616-5p FGF7 0.834052908652744 0.0347835664029363 -1.5602156825587 0.00498637377963977 mirMAP -0.499565899304345 6.56838525058638e-07 NA NA NA hsa-miR-7-1-3p FGF7 0.709309110750947 0.0412301737463194 -1.5602156825587 0.00498637377963977 mirMAP -0.445680137233784 8.82810683468222e-05 NA NA NA hsa-miR-944 FGF7 3.33123095809751 0.0177835044930391 -1.5602156825587 0.00498637377963977 mirMAP -0.136791859053773 3.4948596692363e-05 NA NA NA hsa-miR-16-2-3p FGF9 1.8048179609245 2.83095715136409e-09 -1.74987286650449 0.0113341158170243 mirMAP -0.451752198937279 0.00402672168929665 NA NA NA hsa-miR-205-5p FGF9 3.13520672931882 0.0293226471971167 -1.74987286650449 0.0113341158170243 miRNATAP -0.152174402639521 6.027271820105e-06 NA NA NA hsa-miR-369-3p FGF9 0.32261175629684 0.3589927609891 -1.74987286650449 0.0113341158170243 mirMAP;miRNATAP -0.386601318549715 0.00627732180260434 NA NA NA hsa-miR-455-5p FGF9 1.20462751989145 6.74386011867484e-05 -1.74987286650449 0.0113341158170243 miRanda -0.615588799082101 0.000125067222771029 NA NA NA hsa-miR-944 FGF9 3.33123095809751 0.0177835044930391 -1.74987286650449 0.0113341158170243 mirMAP -0.169847944100435 3.49963470746257e-05 NA NA NA hsa-miR-106b-5p FGFR1 1.70863907461894 2.04074794107142e-08 -1.49877035356464 0.000511032592490219 mirMAP -0.289574146617841 0.00338081665085451 NA NA NA hsa-miR-135b-5p FGFR1 4.09156383496059 1.32294295002438e-12 -1.49877035356464 0.000511032592490219 mirMAP -0.239971522992425 1.30604624157818e-06 NA NA NA hsa-miR-15a-5p FGFR1 1.03783090449383 7.40334108980898e-07 -1.49877035356464 0.000511032592490219 miRNATAP -0.614121259747611 2.31269640677994e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGFR1 1.62046407540723 5.42152621571078e-09 -1.49877035356464 0.000511032592490219 miRNATAP -0.428887511985041 6.35940222533532e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 1.00515772948091 5.33912942007619e-06 -1.49877035356464 0.000511032592490219 miRTarBase;miRNATAP -0.646816679192102 2.46444393209917e-06 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 1.65862087862483 8.45603406215941e-08 -1.49877035356464 0.000511032592490219 mirMAP -0.385666132191953 6.54751310730238e-05 NA NA NA hsa-miR-200a-5p FGFR1 1.50371809098978 0.00263602434344863 -1.49877035356464 0.000511032592490219 mirMAP -0.353457026193588 2.65731844551453e-09 NA NA NA hsa-miR-200b-5p FGFR1 0.969871521250413 0.0530500454130183 -1.49877035356464 0.000511032592490219 mirMAP -0.379845880120484 1.1792923473536e-09 NA NA NA hsa-miR-20a-5p FGFR1 1.4503375861709 5.7813456424762e-07 -1.49877035356464 0.000511032592490219 mirMAP -0.375915424325503 0.00030587275135307 NA NA NA hsa-miR-330-3p FGFR1 0.798460296022179 0.00746538156533435 -1.49877035356464 0.000511032592490219 PITA;miRNATAP -0.282998543312954 0.00663632549076157 NA NA NA hsa-miR-330-5p FGFR1 0.488365986827708 0.0512207630808233 -1.49877035356464 0.000511032592490219 miRanda;miRNATAP -0.46885020733595 0.000163163733168213 NA NA NA hsa-miR-335-3p FGFR1 2.5197689063267 2.20084506976733e-09 -1.49877035356464 0.000511032592490219 mirMAP -0.292645618532702 2.80734523112232e-05 NA NA NA hsa-miR-532-5p FGFR1 0.313080805824184 0.252248939356301 -1.49877035356464 0.000511032592490219 PITA -0.412833293773713 0.000296657475622566 NA NA NA hsa-miR-577 FGFR1 0.911619788986754 0.2256062124148 -1.49877035356464 0.000511032592490219 PITA;mirMAP -0.163290896258138 9.38787002002887e-05 NA NA NA hsa-miR-186-5p FGFR2 0.149964130725901 0.434709542998771 -0.0989978709215018 0.814042278338263 miRNAWalker2_validate -0.416290327670683 0.00939242147576651 NA NA NA hsa-miR-326 FGFR2 -0.429748586406214 0.2629894124021 -0.0989978709215018 0.814042278338263 miRanda -0.227787287684123 0.00384928442941226 NA NA NA hsa-miR-338-3p FGFR2 -0.959276231066179 0.0191473351014091 -0.0989978709215018 0.814042278338263 miRanda;miRNATAP -0.196178980077981 0.00698122481372059 NA NA NA hsa-miR-194-5p FGFR3 -0.127742909829168 0.906065815804667 1.65518678016625 0.0043355270123643 miRNATAP -0.225086870713638 1.12067768221423e-09 NA NA NA hsa-miR-532-5p FGFR3 0.313080805824184 0.252248939356301 1.65518678016625 0.0043355270123643 mirMAP -0.433951889263385 0.0047914041475262 NA NA NA hsa-miR-16-5p FLNA 1.00515772948091 5.33912942007619e-06 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.827881738848939 6.9612528228536e-10 NA NA NA hsa-miR-196a-5p FLNA 6.59255881689547 1.53691144193899e-22 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.274091746125286 1.45025007579472e-12 NA NA NA hsa-miR-200c-3p FLNA 1.28185685499076 0.00369777635539177 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.503986999594505 1.09905371484172e-14 NA NA NA hsa-miR-20a-5p FLNA 1.4503375861709 5.7813456424762e-07 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.568786552642642 2.07249264495414e-08 NA NA NA hsa-miR-221-3p FLNA 1.33496247538338 3.82022531235275e-07 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.488659710562545 1.83895206875089e-05 24443580 In addition the oPD thyroid carcinomas demonstrated upregulation of miR-221 and miR-885-5p thyroid cancer hsa-miR-222-3p FLNA 1.39382731585819 9.98182478024671e-07 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.544619034600024 1.65671740753115e-07 NA NA NA hsa-miR-378a-3p FLNA -0.192828831363649 0.530795182107493 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.317868545532846 0.00171515137030305 NA NA NA hsa-miR-484 FLNA 0.71327898984355 0.00233605130771196 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.367129261982306 0.00582823380053421 NA NA NA hsa-miR-615-3p FLNA 2.82967143704683 3.05118423223543e-05 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.257708487956948 2.69182970182006e-05 NA NA NA hsa-miR-7-5p FLNA 1.63575693499363 0.0124424214624534 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.340682406730971 2.31982324720373e-13 NA NA NA hsa-miR-92a-3p FLNA 1.2209325870225 6.8757197708107e-06 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.576553861971345 1.53706453251178e-07 NA NA NA hsa-miR-34c-5p FLNB 2.20632574870337 0.000379662996168678 -0.0618738005149861 0.823684052594967 miRanda -0.117487369058802 0.00016120632463357 NA NA NA hsa-miR-9-5p FLNB -0.195328736653048 0.761470692992178 -0.0618738005149861 0.823684052594967 miRNAWalker2_validate -0.157891085498421 1.10391875545003e-07 NA NA NA hsa-miR-142-3p FLNC 1.32364054836498 0.0001537753622128 -3.39370843032629 1.01689643843844e-07 miRanda -0.517190024911129 8.13742792728083e-05 NA NA NA hsa-miR-19a-3p FLNC 1.26669687448473 0.000105972838514412 -3.39370843032629 1.01689643843844e-07 miRNATAP -0.922310134873493 8.77423144402313e-12 NA NA NA hsa-miR-19b-3p FLNC 0.759818275708988 0.00652779573186786 -3.39370843032629 1.01689643843844e-07 miRNATAP -1.03998867352314 1.13100693427827e-10 NA NA NA hsa-miR-320a FLNC 0.593888711838028 0.011897419390526 -3.39370843032629 1.01689643843844e-07 PITA;miRanda;miRNATAP -0.837967684680012 2.33505687771093e-05 NA NA NA hsa-miR-320b FLNC 1.11183660885284 0.000497971211648503 -3.39370843032629 1.01689643843844e-07 PITA;miRanda;miRNATAP -0.84691458653415 1.74046338673777e-09 NA NA NA hsa-miR-320c FLNC 0.455072851945474 0.240613785444485 -3.39370843032629 1.01689643843844e-07 PITA;miRanda;miRNATAP -0.498541166403259 0.000360294193776564 NA NA NA hsa-miR-330-5p FLNC 0.488365986827708 0.0512207630808233 -3.39370843032629 1.01689643843844e-07 miRanda -0.734609787935455 8.93804488456252e-05 NA NA NA hsa-miR-454-3p FLNC 0.625199142970745 0.0134890997402741 -3.39370843032629 1.01689643843844e-07 miRNAWalker2_validate -0.956050503834121 1.5247467408534e-07 NA NA NA hsa-miR-455-5p FLNC 1.20462751989145 6.74386011867484e-05 -3.39370843032629 1.01689643843844e-07 miRanda -0.827218710945305 2.89696233194035e-08 NA NA NA hsa-miR-592 FLNC 0.779567202789068 0.204498177014474 -3.39370843032629 1.01689643843844e-07 mirMAP -0.47476314510841 1.90176091523689e-09 NA NA NA hsa-miR-335-3p FOS 2.5197689063267 2.20084506976733e-09 -0.654470642235231 0.153458461271716 MirTarget -0.37093585128559 3.15686202394655e-07 NA NA NA hsa-miR-335-5p FOS 1.59953351087307 5.56170899867314e-05 -0.654470642235231 0.153458461271716 miRNAWalker2_validate -0.308891324939499 0.000115309985320415 NA NA NA hsa-miR-424-3p FOS 0.860888512744971 0.0234638352065231 -0.654470642235231 0.153458461271716 MirTarget;miRNATAP -0.2647669542072 0.00366016062922949 NA NA NA hsa-miR-148b-3p GADD45A 0.295175884456199 0.17466422420702 -0.744381186012481 0.00247182040910746 MirTarget -0.214957101032821 0.00927854827400905 NA NA NA hsa-miR-454-3p GADD45A 0.625199142970745 0.0134890997402741 -0.744381186012481 0.00247182040910746 MirTarget;miRNATAP -0.217978566953222 0.00180852644098547 NA NA NA hsa-miR-1976 GADD45B 0.923172654386147 0.000118514313506673 -1.91754262778042 5.17429057228523e-08 miRNATAP -0.58594227558951 2.17579979542256e-08 NA NA NA hsa-miR-324-3p GADD45B 1.04940352369965 0.000387716796520961 -1.91754262778042 5.17429057228523e-08 MirTarget;miRNATAP -0.3687003729794 1.78715342431653e-05 NA NA NA hsa-miR-590-3p GADD45B 1.11654983899947 0.000160782154924864 -1.91754262778042 5.17429057228523e-08 miRanda -0.368023929046783 1.76170990966765e-05 NA NA NA hsa-miR-296-5p GADD45G 0.932146077883618 0.0602370559607489 -1.30721241002926 0.000929668878156123 miRNATAP -0.168728470747373 0.00456954912760057 NA NA NA hsa-miR-195-5p GNA12 -0.907998841926297 0.00150511564650591 0.300169484818185 0.111223271968186 MirTarget -0.136158182770742 0.00336020211232243 NA NA NA hsa-miR-30d-3p GNA12 -0.545113326540761 0.0433733076874155 0.300169484818185 0.111223271968186 MirTarget -0.25937220245327 8.57446824909441e-08 NA NA NA hsa-miR-335-5p GNA12 1.59953351087307 5.56170899867314e-05 0.300169484818185 0.111223271968186 mirMAP -0.109327795206506 0.00088379829248004 NA NA NA hsa-miR-107 GNG12 0.904627575346218 4.67936495073904e-05 -0.294101873698593 0.112771340553714 miRanda -0.200412767237989 0.000630268384679819 NA NA NA hsa-miR-126-5p GNG12 0.41765430251855 0.0753161203651532 -0.294101873698593 0.112771340553714 mirMAP -0.156388609985589 0.0057405609112311 NA NA NA hsa-miR-140-5p GNG12 0.208193069681326 0.303002433893804 -0.294101873698593 0.112771340553714 PITA;miRanda -0.252822882443761 0.000124004811884371 NA NA NA hsa-miR-374b-5p GNG12 -0.188120735251554 0.394800117237392 -0.294101873698593 0.112771340553714 mirMAP -0.174991830772569 0.00379237778781347 NA NA NA hsa-miR-423-5p GNG12 0.832613878736338 0.000791321227103338 -0.294101873698593 0.112771340553714 miRNAWalker2_validate -0.240235936972391 3.80058099265444e-06 NA NA NA hsa-miR-590-3p GNG12 1.11654983899947 0.000160782154924864 -0.294101873698593 0.112771340553714 miRanda;mirMAP -0.121726190652431 0.00559991009386133 NA NA NA hsa-miR-590-5p GNG12 1.04171442093217 0.000272475544954865 -0.294101873698593 0.112771340553714 PITA -0.130764537784798 0.00404814498177005 NA NA NA hsa-miR-146a-5p HSPA1A 1.82051649415508 2.03651725047679e-05 0.680521240876929 0.0875782801701159 miRNAWalker2_validate -0.183540395806292 0.00477547577659663 NA NA NA hsa-miR-10a-5p HSPA1B -0.470861534765518 0.148803248989189 0.79783151595239 0.0254309848390122 miRNAWalker2_validate -0.235938998851569 0.00260738092834223 NA NA NA hsa-miR-192-5p HSPA2 0.0809146624034405 0.941057093528709 -0.986192174683285 0.0597105673138521 miRNAWalker2_validate -0.302925530934889 2.13891382574116e-23 NA NA NA hsa-miR-215-5p HSPA2 0.715250240418615 0.573784317311889 -0.986192174683285 0.0597105673138521 miRNAWalker2_validate -0.239271479051597 3.76731141676465e-19 NA NA NA hsa-miR-339-5p HSPA2 0.770566566962108 0.00816529093411862 -0.986192174683285 0.0597105673138521 miRanda -0.365075042431976 0.00444916644928213 NA NA NA hsa-miR-500a-3p HSPA2 0.133193057420744 0.668896091969871 -0.986192174683285 0.0597105673138521 miRNATAP -0.538755317654026 5.96544728616438e-06 NA NA NA hsa-miR-7-1-3p HSPA2 0.709309110750947 0.0412301737463194 -0.986192174683285 0.0597105673138521 mirMAP -0.790222196694411 3.76324102898142e-15 NA NA NA hsa-miR-96-5p HSPA2 1.14243043653372 0.00942969392739105 -0.986192174683285 0.0597105673138521 TargetScan -0.254850037002587 0.00396950344187686 NA NA NA hsa-miR-199a-5p HSPA8 0.371973504507027 0.232661597228763 -0.28587752261509 0.121913221559495 miRanda -0.117830411635634 0.00522620110746295 NA NA NA hsa-miR-577 HSPB1 0.911619788986754 0.2256062124148 0.989970535491072 0.0619685121427502 PITA -0.307423833021975 4.79163714338499e-10 NA NA NA hsa-miR-125a-3p IKBKB 1.19506542853853 0.00164364545717311 0.134870081917275 0.507473312093685 miRanda -0.128753900358831 0.000649508610645324 NA NA NA hsa-miR-543 IKBKB 0.0323775903217254 0.929458442755522 0.134870081917275 0.507473312093685 miRanda -0.128643682904471 0.00308168626813573 NA NA NA hsa-miR-125a-5p IKBKG -0.878090699011564 0.000213630844319685 0.482871701565075 0.00797160760932323 miRanda -0.235137534713953 1.20912221589607e-05 NA NA NA hsa-miR-148a-3p IKBKG -1.53721533763578 3.55533747293117e-05 0.482871701565075 0.00797160760932323 mirMAP -0.11630876600781 0.000633185783589711 NA NA NA hsa-miR-191-5p IL1A 0.964929997847221 0.000706019788557095 3.98706567663546 1.16849910667626e-05 miRNAWalker2_validate -0.695822638582492 0.00261744460155118 NA NA NA hsa-miR-200a-3p IL1A 0.717826667295984 0.193912116506827 3.98706567663546 1.16849910667626e-05 MirTarget -0.340606001845334 0.00439380383654693 NA NA NA hsa-miR-30a-5p IL1A -1.71922855140016 3.20574349285256e-07 3.98706567663546 1.16849910667626e-05 MirTarget -0.814660149177838 1.64588406524699e-05 NA NA NA hsa-miR-30b-5p IL1A -0.430720743745757 0.0593564057320791 3.98706567663546 1.16849910667626e-05 MirTarget -0.946999569898049 0.00123879394096619 NA NA NA hsa-miR-30c-5p IL1A -0.983130268805942 4.60419218706127e-05 3.98706567663546 1.16849910667626e-05 MirTarget -1.11897157505593 3.38735639049494e-05 NA NA NA hsa-miR-30d-5p IL1A -0.5492586056147 0.0140125082460125 3.98706567663546 1.16849910667626e-05 MirTarget -1.69859525858947 4.69234742994376e-09 NA NA NA hsa-miR-30e-5p IL1A -0.573784818166736 0.0112497802572927 3.98706567663546 1.16849910667626e-05 MirTarget -0.834034959769621 0.0048151786715307 NA NA NA hsa-miR-532-5p IL1A 0.313080805824184 0.252248939356301 3.98706567663546 1.16849910667626e-05 MirTarget -1.08391384408926 6.80635936079074e-06 NA NA NA hsa-miR-664a-3p IL1A -0.83041219170254 0.000136267547251167 3.98706567663546 1.16849910667626e-05 MirTarget -0.897367435115216 0.00322501864839319 NA NA NA hsa-miR-30a-3p IL1B -1.73205137750899 3.2425754511091e-07 1.26826196984759 0.0328751494712569 MirTarget -0.435934837553166 0.000319780723167766 NA NA NA hsa-miR-126-5p IL1R1 0.41765430251855 0.0753161203651532 -0.906995887568108 0.0047158045114454 mirMAP -0.261436359372816 0.00849952221113025 NA NA NA hsa-miR-130b-5p IL1R1 0.701350393759937 0.0510142718395002 -0.906995887568108 0.0047158045114454 mirMAP -0.368233556139774 2.48100078929972e-09 NA NA NA hsa-miR-17-3p IL1R1 1.31126744284937 3.24768335024185e-07 -0.906995887568108 0.0047158045114454 mirMAP -0.693802269428868 9.46806918483647e-18 NA NA NA hsa-miR-186-5p IL1R1 0.149964130725901 0.434709542998771 -0.906995887568108 0.0047158045114454 mirMAP -0.443167338337515 0.000291088595010789 NA NA NA hsa-miR-197-3p IL1R1 0.888854270009261 0.000195183808214449 -0.906995887568108 0.0047158045114454 miRNAWalker2_validate -0.49613040391323 1.22192346297885e-07 NA NA NA hsa-miR-24-3p IL1R1 1.08578167539644 6.18549359075268e-07 -0.906995887568108 0.0047158045114454 miRNATAP -0.424471721385594 3.86777071307179e-05 NA NA NA hsa-miR-26b-5p IL1R1 -0.301646326928219 0.160081421968103 -0.906995887568108 0.0047158045114454 mirMAP -0.459757391461702 1.97133609463222e-05 NA NA NA hsa-miR-30d-3p IL1R1 -0.545113326540761 0.0433733076874155 -0.906995887568108 0.0047158045114454 mirMAP -0.230736331537232 0.00720309202491904 NA NA NA hsa-miR-335-3p IL1R1 2.5197689063267 2.20084506976733e-09 -0.906995887568108 0.0047158045114454 mirMAP -0.316316666355703 3.02394356078111e-10 NA NA NA hsa-miR-361-5p IL1R1 0.407725414130987 0.0181260969156347 -0.906995887568108 0.0047158045114454 miRanda -0.649361583840372 1.38224165077047e-06 NA NA NA hsa-miR-3662 IL1R1 1.82780708047676 0.0054036501346178 -0.906995887568108 0.0047158045114454 mirMAP -0.139395164254141 0.00185011658369509 NA NA NA hsa-miR-590-3p IL1R1 1.11654983899947 0.000160782154924864 -0.906995887568108 0.0047158045114454 miRanda;miRNATAP -0.32389995746728 2.02766398681884e-05 NA NA NA hsa-miR-15a-5p JUN 1.03783090449383 7.40334108980898e-07 -0.77435217390261 0.0066318712851569 miRNAWalker2_validate -0.275129314608708 0.00431274574294796 NA NA NA hsa-miR-429 JUN 1.40182602301928 0.00900426780286475 -0.77435217390261 0.0066318712851569 MirTarget;PITA;miRanda;miRNATAP -0.102047702155417 0.00679958519946339 NA NA NA hsa-miR-92a-3p JUN 1.2209325870225 6.8757197708107e-06 -0.77435217390261 0.0066318712851569 miRNATAP -0.247580163718491 0.000789716327406544 NA NA NA hsa-miR-93-5p JUN 1.7515174434778 1.59386482413883e-08 -0.77435217390261 0.0066318712851569 miRNAWalker2_validate -0.201774500205283 0.00149110846021834 NA NA NA hsa-let-7a-3p KRAS 0.503048155002889 0.0411145454335299 0.0440663168558286 0.888218969585117 mirMAP;miRNATAP -0.274880026464494 0.00252165954052568 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-miR-143-3p KRAS -0.661937718854688 0.0483213962135842 0.0440663168558286 0.888218969585117 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.177845989861529 0.00743791491988655 22804917;27725862;19137007;26581910;23173124;26824186;21197560 In KRAS mutated tumours increased miR-200b and decreased miR-143 expression were associated with a good PFS;The expression of miR-143 is often down-regulated and it might play an important role by targeting KRAS in colorectal cancer CRC; Dual-luciferase reporter assays were performed to validate whether KRAS was regulated by miR-143; Dual-luciferase assays indicated that KRAS was a direct target of miR-143 as subsequently demonstrated by qPCR and western blot analysis showing that infection of SW480 cells with Ad-ZD55-miR-143 resulted in the down-regulation of KRAS at both mRNA and protein levels;Role of miR 143 targeting KRAS in colorectal tumorigenesis; In particular among a panel of presumed targets generated by in silico analysis that may interact with these aberrantly expressed miRNAs KRAS oncogene has been further experimentally validated as the target of miR-143; First an inverse correlation between KRAS protein and miR-143 in vivo was found; Second KRAS expression in Lovo cells was significantly abolished by treatment with miR-143 mimic whereas miR-143 inhibitor increased KRAS protein level; Third luciferase reporter assay confirmed that miR-143 directly recognize the 3'-untranslated region of KRAS transcripts; Finally inhibition of KRAS expression by miR-143 inhibits constitutive phosphorylation of ERK1/2; Taken together the present study provides the first evidences that miR-143 is significant in suppressing colorectal cancer cell growth through inhibition of KRAS translation;MicroRNA 143 replenishment re sensitizes colorectal cancer cells harboring mutant but not wild type KRAS to paclitaxel treatment; Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS; Combination of miR-143 mimic and paclitaxel induced the onset of apoptosis and reverted in vitro metastatic properties migration and invasion in KRAS mutant tumor cells; MiR-143 thus can be used as a chemosensitizer for the treatment of KRAS mutant tumors and warrants further investigations in in vitro and pre-clinical in vivo models;In turn the level of miR-143 in CRC cells decreasing the amount of MACC1 metastasis-associated in colon cancer-1 and oncogenic KRAS protein may be utilized as a prognostic marker;Stable miR-143 or miR-145 overexpression increased cell sensitivity to cetuximab resulting in a significant increase of cetuximab-mediated ADCC independently of KRAS status;miR 143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS; The expression level of miR-143 and its target gene KRAS were measured by realtime PCR and western blotting respectively; Our results revealed an inverse correlation of expression between miR-143 and KRAS protein in prostate cancer samples Pearson's correlation scatter plots: R = -0.707 P < 0.05; These findings suggest that miR-143 plays an important role in prostate cancer proliferation migration and chemosensitivity by suppressing KRAS and subsequent inactivation of MAPK pathway which provides a potential development of a new approach for the treatment of prostate cancer ;;tumorigenesis;;metastasis;; colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colon cancer;prostate cancer hsa-miR-193b-3p KRAS 0.281752012268679 0.451258902263119 0.0440663168558286 0.888218969585117 miRNAWalker2_validate;MirTarget;miRNATAP -0.202900424593209 0.000628014078688691 25905463 Deregulation of the MiR 193b KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer; Mechanistically KRAS was verified as a direct effector of miR-193b through which the AKT and ERK pathways were modulated and cell growth of PDAC cells was suppressed; Taken together our findings indicate that miR-193b-mediated deregulation of the KRAS axis is involved in pancreatic carcinogenesis and suggest that miR-193b could be a potentially effective target for PDAC therapy tumorigenesis pancreatic cancer hsa-miR-224-3p KRAS 1.52422171450716 0.00650463542340912 0.0440663168558286 0.888218969585117 mirMAP -0.113759821037082 0.00837068880275088 25919696 MicroRNA 224 is associated with colorectal cancer progression and response to 5 fluorouracil based chemotherapy by KRAS dependent and independent mechanisms; MicroRNA-224 was differentially expressed in dysplastic colorectal disease and in isogeneic KRAS WT and mutant HCT116 cells; 5-FU chemosensitivity was significantly increased in miR-224 knockdown cells and in NIH3T3 cells expressing KRAS and BRAF mutant proteins progression;drug resistance colorectal cancer hsa-miR-27b-3p KRAS 0.0836323965901755 0.725273923274 0.0440663168558286 0.888218969585117 miRNATAP -0.310127956853884 0.00104691607104432 NA NA NA hsa-miR-101-3p MAP2K1 -0.451263906815861 0.0283387250173031 0.350529324467741 0.0294686130211343 miRNAWalker2_validate -0.210543062942234 0.00016389062492995 NA NA NA hsa-miR-140-3p MAP2K1 -0.296251775392129 0.127539826012144 0.350529324467741 0.0294686130211343 PITA -0.25457882041555 1.7173921304805e-05 NA NA NA hsa-miR-30c-5p MAP2K1 -0.983130268805942 4.60419218706127e-05 0.350529324467741 0.0294686130211343 miRNAWalker2_validate -0.187593003082029 5.3436762450792e-05 NA NA NA hsa-miR-497-5p MAP2K1 -0.801030912431774 0.00360386743876612 0.350529324467741 0.0294686130211343 miRNAWalker2_validate -0.227085834893879 1.53919190373316e-08 NA NA NA hsa-miR-1271-5p MAP2K3 1.15538250415776 0.00207865862606828 -0.0268189252633029 0.905406231042884 MirTarget -0.168712307499746 6.67475786599516e-05 NA NA NA hsa-miR-214-3p MAP2K3 1.01201534142544 0.00625092909225755 -0.0268189252633029 0.905406231042884 miRNAWalker2_validate -0.188420542208865 8.10512183115032e-06 19859982 HeLa cells that stably overexpress miR-214 downregulate the expression of MEK3 and JNK1 at both mRNA and protein levels; Further investigation revealed that miR-214 regulates the expression of MEK3 and JNK1 by targeting the 3'UTRs of these genes; Collectively these results suggest that miR-214 negatively regulates HeLa cell proliferation by targeting the noncoding regions of MEK3 and JNK1 mRNAs cervical and endocervical cancer hsa-miR-9-5p MAP2K3 -0.195328736653048 0.761470692992178 -0.0268189252633029 0.905406231042884 miRNATAP -0.142501935645192 2.47492717480435e-09 NA NA NA hsa-miR-29a-5p MAP2K4 0.585084040404152 0.023014129158495 -0.37541756724823 0.0435390391101175 mirMAP -0.138443242030792 0.00731441533952427 NA NA NA hsa-miR-30c-5p MAP2K4 -0.983130268805942 4.60419218706127e-05 -0.37541756724823 0.0435390391101175 miRNATAP -0.147831770106006 0.00654781403953551 NA NA NA hsa-miR-502-5p MAP2K4 -0.260297419808178 0.520453580478988 -0.37541756724823 0.0435390391101175 PITA;miRNATAP -0.10959703684973 0.000818361326405575 NA NA NA hsa-miR-532-3p MAP2K4 0.552364451472481 0.0975490365586023 -0.37541756724823 0.0435390391101175 miRNATAP -0.140640850289825 0.000357877476202986 NA NA NA hsa-miR-146b-5p MAP2K5 1.547491371264 6.06614361290688e-08 -0.350390356776084 0.0235322094558322 miRanda -0.155011881431784 2.5020075101154e-05 NA NA NA hsa-miR-34c-3p MAP2K6 2.25273698056457 9.06191072601281e-05 0.7311571842219 0.126262694121468 PITA -0.15686001441281 0.00767769552004685 NA NA NA hsa-miR-125a-5p MAP2K7 -0.878090699011564 0.000213630844319685 -0.0858676797332665 0.527454748916206 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.118377167333726 0.00309330724337644 NA NA NA hsa-miR-125b-5p MAP3K11 -0.509303501421334 0.133265526313161 0.378613728669366 0.0115466009555344 miRNATAP -0.129297152048495 2.99746840302423e-05 24635082 Expression of the miRNA miR-125b and serine/threonine kinase mixed lineage kinase MLK3 was assessed in primary malignant melanoma tissues and several melanoma cell lines by quantitative reverse transcription PCR; The effect of MLK3 and miR-125b on cell proliferation was evaluated by MTS assay and cell invasion was evaluated by Transwell invasion assays; Targeting of MLK3 by miR-125b was evaluated using luciferase reporter assay and western blotting; Using bioinformatics we identified MLK3 as one potential target of miR-125b; miRNA transfection and luciferase assay confirmed that MLK3 was regulated by miR-125b at both the transcriptional and translational levels; MLK3 is a direct target of miR-125b malignant trasformation melanoma hsa-miR-199a-5p MAP3K11 0.371973504507027 0.232661597228763 0.378613728669366 0.0115466009555344 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.159279331905737 2.13800036411333e-06 26717044;26885275 Overexpression of miR 199a 5p decreases esophageal cancer cell proliferation through repression of mitogen activated protein kinase kinase kinase 11 MAP3K11; MiR-199a-5p is predicted to bind mitogen-activated protein kinase kinase kinase 11 MAP3K11 mRNA with high affinity; Forced expression of miR-199a-5p in these cells leads to a decrease in the mRNA and protein levels of MAP3K11 due to decreased MAP3K11 mRNA stability; A direct binding interaction between miR-199a-5p and MAP3K11 mRNA is demonstrated using biotin pull-down assays and heterologous luciferase reporter constructs and confirmed by mutational analysis; These findings suggest that miR-199a-5p acts as a tumor suppressor in esophageal cancer cells and that its downregulation contributes to enhanced cellular proliferation by targeting MAP3K11;Further investigation reported that MLK3 was a direct target of miR-199a-5p; Moreover the expression level of miR-199a-5p was conversely correlated with MLK3 in bladder cancerous cells; In addition reintroduction of MLK3 was identified to promote the proliferation and inhibit the apoptotic rate of cells which have been altered by miR-199a-5p through activating the NF-κB pathway ; esophageal cancer;bladder cancer hsa-miR-199b-5p MAP3K11 0.124595928096068 0.678156859366405 0.378613728669366 0.0115466009555344 PITA;miRanda;miRNATAP -0.125714967221919 0.000385649607166211 NA NA NA hsa-miR-106b-5p MAP3K12 1.70863907461894 2.04074794107142e-08 -0.311584996900345 0.264032102252747 MirTarget -0.217788522390735 0.00050312928270912 NA NA NA hsa-miR-130b-3p MAP3K12 1.32714007211004 4.78676252285191e-05 -0.311584996900345 0.264032102252747 MirTarget;miRNATAP -0.216484762430242 0.000265185956163642 NA NA NA hsa-miR-17-5p MAP3K12 1.65862087862483 8.45603406215941e-08 -0.311584996900345 0.264032102252747 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.249152619847258 5.01568542739181e-05 NA NA NA hsa-miR-191-5p MAP3K12 0.964929997847221 0.000706019788557095 -0.311584996900345 0.264032102252747 MirTarget -0.266807332319999 9.88100468834872e-05 NA NA NA hsa-miR-19a-3p MAP3K12 1.26669687448473 0.000105972838514412 -0.311584996900345 0.264032102252747 MirTarget -0.220508977428985 0.000203847933945324 NA NA NA hsa-miR-19b-3p MAP3K12 0.759818275708988 0.00652779573186786 -0.311584996900345 0.264032102252747 MirTarget -0.256003877402253 0.000280371176305902 NA NA NA hsa-miR-20a-5p MAP3K12 1.4503375861709 5.7813456424762e-07 -0.311584996900345 0.264032102252747 miRNAWalker2_validate;miRTarBase;MirTarget -0.22881279858398 0.000565420873277734 NA NA NA hsa-miR-26b-5p MAP3K12 -0.301646326928219 0.160081421968103 -0.311584996900345 0.264032102252747 miRNAWalker2_validate -0.267038280090527 0.00447565432663362 NA NA NA hsa-miR-301b-3p MAP3K12 1.10080095582241 0.0715568440482997 -0.311584996900345 0.264032102252747 MirTarget -0.127276046633446 0.00398117372760744 NA NA NA hsa-miR-429 MAP3K12 1.40182602301928 0.00900426780286475 -0.311584996900345 0.264032102252747 miRNATAP -0.256330397292945 9.5592197416843e-14 NA NA NA hsa-miR-577 MAP3K12 0.911619788986754 0.2256062124148 -0.311584996900345 0.264032102252747 PITA -0.116603012474507 1.05447724205926e-05 NA NA NA hsa-miR-590-3p MAP3K12 1.11654983899947 0.000160782154924864 -0.311584996900345 0.264032102252747 miRanda -0.204422456366247 0.00200002510560224 NA NA NA hsa-miR-615-3p MAP3K12 2.82967143704683 3.05118423223543e-05 -0.311584996900345 0.264032102252747 miRNATAP -0.108197524336224 0.00639847275571238 NA NA NA hsa-miR-671-3p MAP3K12 1.16199446005059 0.000404240109143589 -0.311584996900345 0.264032102252747 PITA -0.201548268127859 0.000879112386797842 NA NA NA hsa-miR-125b-5p MAP3K13 -0.509303501421334 0.133265526313161 0.158335744707323 0.687979347137524 miRNATAP -0.377450194891373 3.46391092809155e-06 NA NA NA hsa-miR-127-5p MAP3K13 0.684144175589776 0.021634535736883 0.158335744707323 0.687979347137524 mirMAP -0.374008889222163 5.97753401896825e-05 NA NA NA hsa-miR-1271-5p MAP3K13 1.15538250415776 0.00207865862606828 0.158335744707323 0.687979347137524 mirMAP -0.463168261214512 1.14545974496032e-10 NA NA NA hsa-miR-149-5p MAP3K13 0.706277554734069 0.296848731347677 0.158335744707323 0.687979347137524 MirTarget -0.26668803580636 1.09969750726549e-11 NA NA NA hsa-miR-183-5p MAP3K13 1.65900927871187 0.000522025364980187 0.158335744707323 0.687979347137524 MirTarget;miRNATAP -0.191877098292451 0.000837398119023911 NA NA NA hsa-miR-203a-3p MAP3K13 1.44736908507496 0.0394116388736904 0.158335744707323 0.687979347137524 MirTarget -0.124090265225811 0.00165400316097451 NA NA NA hsa-miR-205-5p MAP3K13 3.13520672931882 0.0293226471971167 0.158335744707323 0.687979347137524 MirTarget;miRNATAP -0.130244873566391 1.09570132354847e-12 NA NA NA hsa-miR-224-3p MAP3K13 1.52422171450716 0.00650463542340912 0.158335744707323 0.687979347137524 mirMAP -0.193386741429207 0.000334746080350612 NA NA NA hsa-miR-23a-3p MAP3K13 1.10685926969665 3.16223452471768e-08 0.158335744707323 0.687979347137524 mirMAP -0.70128369882746 1.84660539228962e-07 NA NA NA hsa-miR-23b-3p MAP3K13 -0.286465516491361 0.18664668472995 0.158335744707323 0.687979347137524 mirMAP -0.39802014733802 0.00242918441333204 NA NA NA hsa-miR-24-3p MAP3K13 1.08578167539644 6.18549359075268e-07 0.158335744707323 0.687979347137524 MirTarget -0.656377319676349 1.14001886713705e-07 NA NA NA hsa-miR-27a-3p MAP3K13 1.29886998470345 2.68986118553486e-08 0.158335744707323 0.687979347137524 MirTarget -0.585234052579291 3.15090413781801e-07 NA NA NA hsa-miR-27b-3p MAP3K13 0.0836323965901755 0.725273923274 0.158335744707323 0.687979347137524 MirTarget -0.451189530804517 0.000141801756619171 NA NA NA hsa-miR-34c-3p MAP3K13 2.25273698056457 9.06191072601281e-05 0.158335744707323 0.687979347137524 mirMAP -0.210265532994 9.91229946550877e-06 NA NA NA hsa-miR-369-3p MAP3K13 0.32261175629684 0.3589927609891 0.158335744707323 0.687979347137524 mirMAP;miRNATAP -0.234093150701826 0.00336868092010294 NA NA NA hsa-miR-369-5p MAP3K13 -0.108799720438673 0.768582611640479 0.158335744707323 0.687979347137524 miRNATAP -0.215111928123886 0.00476548560381517 NA NA NA hsa-miR-409-3p MAP3K13 0.648757698056077 0.0515133779537138 0.158335744707323 0.687979347137524 mirMAP -0.273944938360377 0.00108347811185273 NA NA NA hsa-miR-708-5p MAP3K13 1.41830449251856 0.0109647946476309 0.158335744707323 0.687979347137524 MirTarget;miRNATAP -0.279660981565326 6.313069928831e-09 NA NA NA hsa-miR-940 MAP3K13 1.64406174271686 0.000690854900107004 0.158335744707323 0.687979347137524 MirTarget;miRNATAP -0.273464245035359 4.09857205480566e-05 NA NA NA hsa-miR-944 MAP3K13 3.33123095809751 0.0177835044930391 0.158335744707323 0.687979347137524 PITA;mirMAP;miRNATAP -0.155627739809939 2.92344119080812e-12 NA NA NA hsa-miR-17-3p MAP3K14 1.31126744284937 3.24768335024185e-07 -0.259250519497319 0.26795775361 MirTarget -0.190284157688133 0.00260851214537523 NA NA NA hsa-miR-17-5p MAP3K14 1.65862087862483 8.45603406215941e-08 -0.259250519497319 0.26795775361 MirTarget -0.141133091627603 0.00671504081676105 NA NA NA hsa-miR-185-3p MAP3K14 1.33711019171256 3.45756583967985e-05 -0.259250519497319 0.26795775361 MirTarget -0.248869688925321 4.8658984259307e-07 NA NA NA hsa-miR-345-5p MAP3K14 1.83686164833727 1.1036889735857e-08 -0.259250519497319 0.26795775361 MirTarget -0.131943070340609 0.00816023179144145 NA NA NA hsa-miR-429 MAP3K14 1.40182602301928 0.00900426780286475 -0.259250519497319 0.26795775361 miRNATAP -0.101734240054609 0.000846699347081948 NA NA NA hsa-miR-542-3p MAP3K14 0.757649022262991 0.00210575463285599 -0.259250519497319 0.26795775361 miRanda -0.191756297239305 0.00447914443598292 27107696 miR 542 3p suppresses invasion and metastasis by targeting the proto oncogene serine/threonine protein kinase PIM1 in melanoma; The proto-oncogene serine/threonine protein kinase PIM1 was identified as a direct target of miR-542-3p using luciferase reporter assay qRT-PCR and western blot analyses metastasis melanoma hsa-let-7d-5p MAP3K2 0.981733854788227 7.26366577706469e-07 0.108894457152557 0.57094125471357 miRNATAP -0.186233178314446 0.00620111174461947 NA NA NA hsa-miR-101-3p MAP3K2 -0.451263906815861 0.0283387250173031 0.108894457152557 0.57094125471357 MirTarget -0.2535444309362 0.000137235194270938 NA NA NA hsa-miR-106b-5p MAP3K2 1.70863907461894 2.04074794107142e-08 0.108894457152557 0.57094125471357 MirTarget;miRNATAP -0.171337507872653 5.91871993469426e-05 NA NA NA hsa-miR-126-5p MAP3K2 0.41765430251855 0.0753161203651532 0.108894457152557 0.57094125471357 MirTarget -0.18595630283791 0.00143621949896585 NA NA NA hsa-miR-142-5p MAP3K2 1.55592486377018 6.69269968016779e-06 0.108894457152557 0.57094125471357 MirTarget;PITA -0.124864621261137 0.00112056062722691 NA NA NA hsa-miR-26a-5p MAP3K2 -0.384110714440647 0.0442498636014044 0.108894457152557 0.57094125471357 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.267672008285467 0.000207669828869753 NA NA NA hsa-miR-26b-5p MAP3K2 -0.301646326928219 0.160081421968103 0.108894457152557 0.57094125471357 mirMAP;miRNATAP -0.213577806184108 0.000863575750420875 NA NA NA hsa-miR-320b MAP3K2 1.11183660885284 0.000497971211648503 0.108894457152557 0.57094125471357 miRanda;mirMAP -0.132310665590079 0.00163296203629895 NA NA NA hsa-miR-330-3p MAP3K2 0.798460296022179 0.00746538156533435 0.108894457152557 0.57094125471357 mirMAP;miRNATAP -0.178948515019288 6.89117895267756e-05 NA NA NA hsa-miR-335-5p MAP3K2 1.59953351087307 5.56170899867314e-05 0.108894457152557 0.57094125471357 mirMAP;miRNATAP -0.117532882498726 0.000430161507293264 NA NA NA hsa-miR-340-5p MAP3K2 -0.164941927483643 0.529910509321278 0.108894457152557 0.57094125471357 MirTarget;mirMAP -0.208843926084403 5.40342533835604e-05 NA NA NA hsa-miR-766-3p MAP3K2 0.362693027508444 0.224058260234353 0.108894457152557 0.57094125471357 MirTarget -0.138288127619319 0.00248155392574632 NA NA NA hsa-miR-106a-5p MAP3K3 -0.173255688252641 0.642872703263671 -0.635113788094134 0.000172463517599492 MirTarget;miRNATAP -0.114105115778531 0.000423286363900987 NA NA NA hsa-miR-106b-5p MAP3K3 1.70863907461894 2.04074794107142e-08 -0.635113788094134 0.000172463517599492 MirTarget;miRNATAP -0.198475441911016 1.26075929456601e-07 NA NA NA hsa-miR-107 MAP3K3 0.904627575346218 4.67936495073904e-05 -0.635113788094134 0.000172463517599492 PITA;miRanda;miRNATAP -0.189520078364271 0.000463284905410886 NA NA NA hsa-miR-1254 MAP3K3 0.941374574140312 0.0605480748500796 -0.635113788094134 0.000172463517599492 miRNATAP -0.137381126432742 1.41478167832026e-06 NA NA NA hsa-miR-141-3p MAP3K3 1.45548825076434 0.00115958850961764 -0.635113788094134 0.000172463517599492 miRNATAP -0.242960322980531 1.18740415360491e-24 NA NA NA hsa-miR-15a-5p MAP3K3 1.03783090449383 7.40334108980898e-07 -0.635113788094134 0.000172463517599492 MirTarget;miRNATAP -0.310876618782426 2.2351860858683e-08 NA NA NA hsa-miR-15b-5p MAP3K3 1.62046407540723 5.42152621571078e-09 -0.635113788094134 0.000172463517599492 MirTarget;miRNATAP -0.207866051879661 4.80530128492327e-07 NA NA NA hsa-miR-16-5p MAP3K3 1.00515772948091 5.33912942007619e-06 -0.635113788094134 0.000172463517599492 MirTarget;miRNATAP -0.297504451288496 1.81881814426419e-08 NA NA NA hsa-miR-17-5p MAP3K3 1.65862087862483 8.45603406215941e-08 -0.635113788094134 0.000172463517599492 MirTarget;TargetScan;miRNATAP -0.282247284960558 1.75654146177207e-15 NA NA NA hsa-miR-181a-5p MAP3K3 1.39227281909646 1.91689469974826e-09 -0.635113788094134 0.000172463517599492 MirTarget;miRNATAP -0.169316676563001 0.000811154359985253 NA NA NA hsa-miR-181b-5p MAP3K3 1.64216500592669 1.89228845300725e-08 -0.635113788094134 0.000172463517599492 MirTarget;miRNATAP -0.139229625339754 0.000500508016962031 NA NA NA hsa-miR-182-5p MAP3K3 0.887369486030646 0.0310640781418789 -0.635113788094134 0.000172463517599492 miRNATAP -0.194601394218559 2.89264596702314e-12 NA NA NA hsa-miR-185-3p MAP3K3 1.33711019171256 3.45756583967985e-05 -0.635113788094134 0.000172463517599492 MirTarget -0.180298078939508 6.24433060064248e-07 NA NA NA hsa-miR-188-5p MAP3K3 1.35426907033843 0.00038346077691455 -0.635113788094134 0.000172463517599492 MirTarget;PITA;miRNATAP -0.113557571479449 0.000269483276680044 NA NA NA hsa-miR-200a-3p MAP3K3 0.717826667295984 0.193912116506827 -0.635113788094134 0.000172463517599492 miRNATAP -0.147657665614778 1.02454372328888e-12 NA NA NA hsa-miR-20a-5p MAP3K3 1.4503375861709 5.7813456424762e-07 -0.635113788094134 0.000172463517599492 MirTarget;miRNATAP -0.298318007901604 5.71695748326143e-15 NA NA NA hsa-miR-221-5p MAP3K3 1.88626894114756 8.2644671350768e-08 -0.635113788094134 0.000172463517599492 mirMAP -0.110900653752184 0.00188765931502394 NA NA NA hsa-miR-330-3p MAP3K3 0.798460296022179 0.00746538156533435 -0.635113788094134 0.000172463517599492 mirMAP -0.118807146546731 0.00339710066657885 NA NA NA hsa-miR-331-3p MAP3K3 1.04880525429426 9.99995355989124e-05 -0.635113788094134 0.000172463517599492 mirMAP -0.172372697585048 9.61334052871608e-05 NA NA NA hsa-miR-33a-5p MAP3K3 0.407757858040717 0.321429014317207 -0.635113788094134 0.000172463517599492 miRNATAP -0.195288312692551 3.21804649596143e-12 NA NA NA hsa-miR-33b-5p MAP3K3 0.267227362818466 0.614814331176942 -0.635113788094134 0.000172463517599492 miRNATAP -0.1041759898518 0.000390884259023741 NA NA NA hsa-miR-424-5p MAP3K3 1.08509868581983 0.000420473853818268 -0.635113788094134 0.000172463517599492 MirTarget;miRNATAP -0.193815652040064 3.89609754633855e-07 NA NA NA hsa-miR-429 MAP3K3 1.40182602301928 0.00900426780286475 -0.635113788094134 0.000172463517599492 miRNATAP -0.164049225287635 4.39857495430768e-15 NA NA NA hsa-miR-450b-5p MAP3K3 0.46157963033014 0.13273722727895 -0.635113788094134 0.000172463517599492 mirMAP -0.152723546972739 0.000102558597164189 NA NA NA hsa-miR-484 MAP3K3 0.71327898984355 0.00233605130771196 -0.635113788094134 0.000172463517599492 miRNATAP -0.190818955317008 0.000217470696215699 NA NA NA hsa-miR-505-3p MAP3K3 0.82660100642669 0.00111666333288398 -0.635113788094134 0.000172463517599492 miRNATAP -0.17545673693979 0.000217345166386517 NA NA NA hsa-miR-7-1-3p MAP3K3 0.709309110750947 0.0412301737463194 -0.635113788094134 0.000172463517599492 mirMAP -0.143307097630084 3.19961394991541e-05 NA NA NA hsa-miR-93-5p MAP3K3 1.7515174434778 1.59386482413883e-08 -0.635113788094134 0.000172463517599492 MirTarget;miRNATAP -0.225700099742483 5.58417612150787e-10 NA NA NA hsa-miR-96-5p MAP3K3 1.14243043653372 0.00942969392739105 -0.635113788094134 0.000172463517599492 MirTarget;TargetScan;miRNATAP -0.196539143333573 4.30712196699076e-13 NA NA NA hsa-miR-320a MAP3K4 0.593888711838028 0.011897419390526 0.167685959413712 0.343386305890834 miRanda -0.176470559279495 0.000890273077408041 NA NA NA hsa-miR-106b-5p MAP3K5 1.70863907461894 2.04074794107142e-08 -0.710393960443549 0.0017424744162989 miRNATAP -0.187705679170951 0.000252793641461134 NA NA NA hsa-miR-17-5p MAP3K5 1.65862087862483 8.45603406215941e-08 -0.710393960443549 0.0017424744162989 TargetScan;miRNATAP -0.165133514777742 0.00115489764195245 NA NA NA hsa-miR-20a-5p MAP3K5 1.4503375861709 5.7813456424762e-07 -0.710393960443549 0.0017424744162989 miRNATAP -0.145689817013634 0.00785936303566378 NA NA NA hsa-miR-23a-3p MAP3K5 1.10685926969665 3.16223452471768e-08 -0.710393960443549 0.0017424744162989 miRNATAP -0.21242812586475 0.00800640896426164 NA NA NA hsa-miR-769-3p MAP3K5 1.38615307776278 4.57495734358166e-05 -0.710393960443549 0.0017424744162989 miRNAWalker2_validate -0.131633510482035 0.00775180612638095 NA NA NA hsa-miR-93-5p MAP3K5 1.7515174434778 1.59386482413883e-08 -0.710393960443549 0.0017424744162989 miRNATAP -0.171439689901589 0.000684701236155834 NA NA NA hsa-miR-362-5p MAP3K6 -0.354508685915981 0.354912078595613 -0.220028812881696 0.474797991682883 miRNATAP -0.392284654732122 3.68002799755198e-13 NA NA NA hsa-miR-592 MAP3K6 0.779567202789068 0.204498177014474 -0.220028812881696 0.474797991682883 miRNATAP -0.225039893136592 8.57356515470093e-10 NA NA NA hsa-miR-92a-3p MAP3K6 1.2209325870225 6.8757197708107e-06 -0.220028812881696 0.474797991682883 miRNAWalker2_validate -0.265453687008867 0.000773200397016226 NA NA NA hsa-miR-139-5p MAP3K7 -1.83374360776637 1.22019901002824e-09 0.298086543298459 0.0266911319593186 MirTarget -0.128170199077888 1.68429831319826e-05 NA NA NA hsa-miR-374b-5p MAP3K7 -0.188120735251554 0.394800117237392 0.298086543298459 0.0266911319593186 mirMAP -0.134772699504178 0.0019784346635667 NA NA NA hsa-let-7a-3p MAP3K8 0.503048155002889 0.0411145454335299 -0.0978677241058197 0.747374798720068 MirTarget -0.239634335962654 0.00670314442256559 NA NA NA hsa-let-7b-3p MAP3K8 0.21838629112113 0.296038413622566 -0.0978677241058197 0.747374798720068 MirTarget -0.297080729068498 0.00479645896566517 NA NA NA hsa-let-7g-3p MAP3K8 0.64979533805273 0.0103084600883006 -0.0978677241058197 0.747374798720068 MirTarget -0.281164121021456 0.000965566041856375 NA NA NA hsa-miR-17-5p MAP3K8 1.65862087862483 8.45603406215941e-08 -0.0978677241058197 0.747374798720068 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.179337714250841 0.00805355064007169 NA NA NA hsa-let-7a-2-3p MAP4K3 0.195895719455896 0.643556335039042 -0.555818135837971 0.00141893154704322 MirTarget -0.148705929483502 3.62400956307258e-07 NA NA NA hsa-let-7a-3p MAP4K3 0.503048155002889 0.0411145454335299 -0.555818135837971 0.00141893154704322 mirMAP -0.202504432779114 5.92585689395826e-05 NA NA NA hsa-let-7b-3p MAP4K3 0.21838629112113 0.296038413622566 -0.555818135837971 0.00141893154704322 mirMAP -0.222748070275798 0.000222717542498842 NA NA NA hsa-let-7b-5p MAP4K3 0.0582902155815681 0.781400138984745 -0.555818135837971 0.00141893154704322 MirTarget;miRNATAP -0.267289602876756 7.29230115579559e-06 NA NA NA hsa-let-7i-5p MAP4K3 0.798954594465461 2.99735653959449e-05 -0.555818135837971 0.00141893154704322 MirTarget;miRNATAP -0.189651234842881 0.00364530234285149 NA NA NA hsa-let-7g-5p MAP4K4 0.325297685027927 0.241142963826631 0.70921371163141 0.000919229711828298 MirTarget -0.210404675825234 0.000142130041122098 NA NA NA hsa-miR-10a-5p MAP4K4 -0.470861534765518 0.148803248989189 0.70921371163141 0.000919229711828298 MirTarget -0.239832474748424 1.930546066699e-07 NA NA NA hsa-miR-139-5p MAP4K4 -1.83374360776637 1.22019901002824e-09 0.70921371163141 0.000919229711828298 miRanda -0.129660014508748 0.00809334258962538 NA NA NA hsa-miR-148a-5p MAP4K4 -0.69329616490858 0.0793012233740369 0.70921371163141 0.000919229711828298 MirTarget;miRNATAP -0.154042136293461 5.97630286813468e-05 NA NA NA hsa-miR-200b-3p MAP4K4 0.974577911407732 0.0595020056914543 0.70921371163141 0.000919229711828298 TargetScan -0.106337573652147 0.000287172722916631 NA NA NA hsa-miR-29b-3p MAP4K4 -0.230693226193598 0.367461626035234 0.70921371163141 0.000919229711828298 miRNATAP -0.179203966467947 0.0031130758247778 NA NA NA hsa-miR-29c-3p MAP4K4 -1.62454036584589 5.38376515586029e-07 0.70921371163141 0.000919229711828298 miRNATAP -0.202206240361896 8.56928724959732e-06 NA NA NA hsa-miR-7-1-3p MAP4K4 0.709309110750947 0.0412301737463194 0.70921371163141 0.000919229711828298 mirMAP -0.147488505568019 0.000790026590705244 NA NA NA hsa-miR-126-5p MAPK1 0.41765430251855 0.0753161203651532 -0.495098981122446 0.000571417199694919 mirMAP -0.124608202204108 0.00475675613750838 NA NA NA hsa-miR-140-3p MAPK1 -0.296251775392129 0.127539826012144 -0.495098981122446 0.000571417199694919 PITA;miRNATAP -0.145247944412064 0.0071251228758136 NA NA NA hsa-miR-140-5p MAPK1 0.208193069681326 0.303002433893804 -0.495098981122446 0.000571417199694919 miRanda -0.168814127617461 0.00108046906118217 NA NA NA hsa-miR-142-5p MAPK1 1.55592486377018 6.69269968016779e-06 -0.495098981122446 0.000571417199694919 mirMAP -0.122335014287939 1.92619380509704e-05 NA NA NA hsa-miR-16-5p MAPK1 1.00515772948091 5.33912942007619e-06 -0.495098981122446 0.000571417199694919 mirMAP -0.128343010905179 0.00527308486345473 NA NA NA hsa-miR-17-3p MAPK1 1.31126744284937 3.24768335024185e-07 -0.495098981122446 0.000571417199694919 mirMAP -0.106169760608366 0.00660645385547114 NA NA NA hsa-miR-32-5p MAPK1 0.415247682945382 0.106458022460373 -0.495098981122446 0.000571417199694919 mirMAP -0.131661373347466 0.00100556712965003 NA NA NA hsa-miR-320a MAPK1 0.593888711838028 0.011897419390526 -0.495098981122446 0.000571417199694919 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.124406693534882 0.00441330639927605 NA NA NA hsa-miR-320b MAPK1 1.11183660885284 0.000497971211648503 -0.495098981122446 0.000571417199694919 PITA;miRanda;miRNATAP -0.118699294587812 0.000165603061513233 NA NA NA hsa-miR-3614-3p MAPK1 0.816988052098069 0.0143572924352078 -0.495098981122446 0.000571417199694919 mirMAP -0.143042145876837 4.60745685333775e-06 NA NA NA hsa-miR-19a-3p MAPK10 1.26669687448473 0.000105972838514412 -1.47838450058589 0.0146695449243249 miRNATAP -0.524620072624796 5.21292571232218e-05 NA NA NA hsa-miR-19b-3p MAPK10 0.759818275708988 0.00652779573186786 -1.47838450058589 0.0146695449243249 miRNATAP -0.446352029711074 0.00407749072585118 NA NA NA hsa-miR-221-3p MAPK10 1.33496247538338 3.82022531235275e-07 -1.47838450058589 0.0146695449243249 miRNATAP -0.480525331298863 0.00291630181964075 NA NA NA hsa-miR-222-3p MAPK10 1.39382731585819 9.98182478024671e-07 -1.47838450058589 0.0146695449243249 miRNATAP -0.559621471278604 0.000154746484340658 NA NA NA hsa-miR-29a-3p MAPK10 -0.113012156986374 0.615005009685815 -1.47838450058589 0.0146695449243249 miRNATAP -0.59141099824068 0.00261044477988932 NA NA NA hsa-miR-29b-3p MAPK10 -0.230693226193598 0.367461626035234 -1.47838450058589 0.0146695449243249 miRNATAP -0.60205184803829 0.00041835019777687 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-429 MAPK10 1.40182602301928 0.00900426780286475 -1.47838450058589 0.0146695449243249 miRNATAP -0.299587023670623 0.000162775320837701 NA NA NA hsa-miR-590-3p MAPK10 1.11654983899947 0.000160782154924864 -1.47838450058589 0.0146695449243249 miRanda;mirMAP -0.435912555464834 0.00265451734998232 NA NA NA hsa-miR-590-5p MAPK10 1.04171442093217 0.000272475544954865 -1.47838450058589 0.0146695449243249 PITA;miRanda;miRNATAP -0.504910398592333 0.000753214066446178 NA NA NA hsa-miR-361-3p MAPK11 -0.126462931388735 0.566052688733137 -0.0718085853119947 0.830244671743565 mirMAP -0.410420544598358 0.000168711320979975 NA NA NA hsa-miR-130a-3p MAPK8 0.146223920674657 0.633739795905839 0.047155182901105 0.800634305321577 mirMAP -0.142153642233879 0.000967428320783935 NA NA NA hsa-miR-193b-3p MAPK8 0.281752012268679 0.451258902263119 0.047155182901105 0.800634305321577 miRNAWalker2_validate -0.110566260184176 0.00170018129216572 NA NA NA hsa-miR-214-3p MAPK8 1.01201534142544 0.00625092909225755 0.047155182901105 0.800634305321577 miRNAWalker2_validate -0.100393295669915 0.00454338816784626 19859982 HeLa cells that stably overexpress miR-214 downregulate the expression of MEK3 and JNK1 at both mRNA and protein levels; Further investigation revealed that miR-214 regulates the expression of MEK3 and JNK1 by targeting the 3'UTRs of these genes; Collectively these results suggest that miR-214 negatively regulates HeLa cell proliferation by targeting the noncoding regions of MEK3 and JNK1 mRNAs cervical and endocervical cancer hsa-miR-22-5p MAPK8 0.804348748654247 0.000804065112767412 0.047155182901105 0.800634305321577 mirMAP -0.160857639824075 0.00339109702841305 NA NA NA hsa-let-7g-5p MAPK8IP2 0.325297685027927 0.241142963826631 0.636201290510775 0.266531323608437 mirMAP -0.557416262378008 0.000148992123877219 NA NA NA hsa-miR-2110 MAPK8IP2 0.759864042760204 0.0723961390557655 0.636201290510775 0.266531323608437 mirMAP -0.381424034294648 7.76445241864145e-05 NA NA NA hsa-miR-423-5p MAPK8IP2 0.832613878736338 0.000791321227103338 0.636201290510775 0.266531323608437 mirMAP -0.426625711968339 0.00951719643302833 NA NA NA hsa-let-7i-5p MAPK9 0.798954594465461 2.99735653959449e-05 -0.457166211786093 0.00433538908909622 miRNATAP -0.162923938978581 0.00646417150753322 NA NA NA hsa-miR-199a-3p MAPK9 0.85352674491639 0.000360518331912285 -0.457166211786093 0.00433538908909622 miRNAWalker2_validate -0.148619430258245 0.00173860851866056 NA NA NA hsa-miR-24-3p MAPK9 1.08578167539644 6.18549359075268e-07 -0.457166211786093 0.00433538908909622 miRNATAP -0.165659037825773 0.00129654715142099 NA NA NA hsa-miR-27b-3p MAPK9 0.0836323965901755 0.725273923274 -0.457166211786093 0.00433538908909622 miRNAWalker2_validate -0.145750595301133 0.00269156719381644 NA NA NA hsa-miR-1254 MAPT 0.941374574140312 0.0605480748500796 -2.81191222244128 4.84362522030442e-06 MirTarget -0.377279558654038 0.000421149045925389 NA NA NA hsa-miR-146b-5p MAPT 1.547491371264 6.06614361290688e-08 -2.81191222244128 4.84362522030442e-06 PITA;miRNATAP -0.468321383035107 0.00214375261366285 NA NA NA hsa-miR-148b-5p MAPT 1.04409494910362 0.00195860954157389 -2.81191222244128 4.84362522030442e-06 mirMAP -0.602951339670282 3.52078806794049e-06 NA NA NA hsa-miR-17-3p MAPT 1.31126744284937 3.24768335024185e-07 -2.81191222244128 4.84362522030442e-06 mirMAP -0.758685005422248 6.90079529001741e-06 NA NA NA hsa-miR-181a-5p MAPT 1.39227281909646 1.91689469974826e-09 -2.81191222244128 4.84362522030442e-06 miRNATAP -0.751319485742936 5.38785488908466e-05 NA NA NA hsa-miR-181b-5p MAPT 1.64216500592669 1.89228845300725e-08 -2.81191222244128 4.84362522030442e-06 miRNATAP -0.646708643966663 1.05599631325487e-05 NA NA NA hsa-miR-18a-3p MAPT 2.35188582849667 1.39401350286321e-08 -2.81191222244128 4.84362522030442e-06 MirTarget;miRNATAP -0.574105834438117 1.46068302572239e-08 NA NA NA hsa-miR-29a-5p MAPT 0.585084040404152 0.023014129158495 -2.81191222244128 4.84362522030442e-06 MirTarget;miRNATAP -0.905908513291011 1.20427543122891e-07 NA NA NA hsa-miR-320b MAPT 1.11183660885284 0.000497971211648503 -2.81191222244128 4.84362522030442e-06 miRanda -0.65087487426049 1.95702876270691e-06 NA NA NA hsa-miR-335-5p MAPT 1.59953351087307 5.56170899867314e-05 -2.81191222244128 4.84362522030442e-06 mirMAP -0.318826045774656 0.00410807499482478 NA NA NA hsa-miR-34a-5p MAPT 0.794251341270032 0.00024017386701179 -2.81191222244128 4.84362522030442e-06 MirTarget;miRNATAP -0.799132729142547 0.000108087675807288 NA NA NA hsa-miR-362-3p MAPT -0.0349414695893027 0.913780708043777 -2.81191222244128 4.84362522030442e-06 MirTarget -0.373449723986913 0.00791268572000626 NA NA NA hsa-miR-429 MAPT 1.40182602301928 0.00900426780286475 -2.81191222244128 4.84362522030442e-06 miRNATAP -0.426129237953061 1.34063525681136e-07 NA NA NA hsa-miR-589-3p MAPT 1.01962606923682 0.00577853347252709 -2.81191222244128 4.84362522030442e-06 mirMAP -0.37188550475959 0.0020454666077602 NA NA NA hsa-miR-589-5p MAPT 0.702695092403762 0.00395772685954799 -2.81191222244128 4.84362522030442e-06 mirMAP -0.586304135482673 0.00147971176688883 NA NA NA hsa-miR-615-3p MAPT 2.82967143704683 3.05118423223543e-05 -2.81191222244128 4.84362522030442e-06 MirTarget;miRNATAP -0.236034325799723 0.00876739872600759 NA NA NA hsa-miR-7-1-3p MAPT 0.709309110750947 0.0412301737463194 -2.81191222244128 4.84362522030442e-06 mirMAP -0.736895190688855 3.56415130587352e-09 NA NA NA hsa-miR-93-3p MAPT 1.88964231421793 1.80075645722786e-08 -2.81191222244128 4.84362522030442e-06 mirMAP -0.50145308913267 8.96055410638441e-05 NA NA NA hsa-let-7a-3p MEF2C 0.503048155002889 0.0411145454335299 -0.551981334021318 0.0959984642799439 MirTarget;miRNATAP -0.410697327186213 1.69297101511047e-05 NA NA NA hsa-let-7b-3p MEF2C 0.21838629112113 0.296038413622566 -0.551981334021318 0.0959984642799439 MirTarget;miRNATAP -0.458095548153094 6.05096244356267e-05 NA NA NA hsa-let-7b-5p MEF2C 0.0582902155815681 0.781400138984745 -0.551981334021318 0.0959984642799439 miRNAWalker2_validate;miRNATAP -0.382061930126358 0.000845752328804144 NA NA NA hsa-let-7f-1-3p MEF2C 1.28704406797397 1.17954701106157e-06 -0.551981334021318 0.0959984642799439 MirTarget -0.284399049424126 0.00111064509392096 NA NA NA hsa-miR-103a-2-5p MEF2C 0.808041560899298 0.019989162317947 -0.551981334021318 0.0959984642799439 MirTarget -0.203805294283849 0.00270276632809031 NA NA NA hsa-miR-1296-5p MEF2C 1.24127275671822 0.000834150627135999 -0.551981334021318 0.0959984642799439 MirTarget -0.245895382166279 7.86335771440944e-05 NA NA NA hsa-miR-130b-5p MEF2C 0.701350393759937 0.0510142718395002 -0.551981334021318 0.0959984642799439 MirTarget;miRNATAP -0.370894512532648 5.20339805923087e-09 NA NA NA hsa-miR-135b-5p MEF2C 4.09156383496059 1.32294295002438e-12 -0.551981334021318 0.0959984642799439 MirTarget -0.15883864956533 2.8013210410831e-05 NA NA NA hsa-miR-182-5p MEF2C 0.887369486030646 0.0310640781418789 -0.551981334021318 0.0959984642799439 MirTarget;miRNATAP -0.384943144211542 1.17921209345744e-12 NA NA NA hsa-miR-183-5p MEF2C 1.65900927871187 0.000522025364980187 -0.551981334021318 0.0959984642799439 MirTarget;miRNATAP -0.379291722640355 3.10443595379384e-17 NA NA NA hsa-miR-18a-3p MEF2C 2.35188582849667 1.39401350286321e-08 -0.551981334021318 0.0959984642799439 MirTarget;miRNATAP -0.239022248979584 1.00824841408446e-05 NA NA NA hsa-miR-18a-5p MEF2C 2.20211504140984 1.78678887916334e-09 -0.551981334021318 0.0959984642799439 MirTarget -0.222131502210933 0.000300874897272388 NA NA NA hsa-miR-19a-3p MEF2C 1.26669687448473 0.000105972838514412 -0.551981334021318 0.0959984642799439 miRNATAP -0.220249034978933 0.00197155698585765 NA NA NA hsa-miR-19b-3p MEF2C 0.759818275708988 0.00652779573186786 -0.551981334021318 0.0959984642799439 miRNATAP -0.268221278029972 0.00147546387596427 NA NA NA hsa-miR-200c-5p MEF2C 0.840328528720891 0.0574610665063827 -0.551981334021318 0.0959984642799439 MirTarget -0.290019149086876 4.75063770800727e-07 NA NA NA hsa-miR-203a-3p MEF2C 1.44736908507496 0.0394116388736904 -0.551981334021318 0.0959984642799439 MirTarget -0.237034573181424 3.85942267495781e-14 NA NA NA hsa-miR-224-3p MEF2C 1.52422171450716 0.00650463542340912 -0.551981334021318 0.0959984642799439 MirTarget;mirMAP -0.249628953754519 1.87130563376157e-08 NA NA NA hsa-miR-23a-3p MEF2C 1.10685926969665 3.16223452471768e-08 -0.551981334021318 0.0959984642799439 MirTarget;miRNATAP -0.483485927925636 2.53026957327154e-05 NA NA NA hsa-miR-27a-3p MEF2C 1.29886998470345 2.68986118553486e-08 -0.551981334021318 0.0959984642799439 miRNATAP -0.443463081066671 5.00161584187439e-06 NA NA NA hsa-miR-27b-3p MEF2C 0.0836323965901755 0.725273923274 -0.551981334021318 0.0959984642799439 miRNATAP -0.388758308591324 9.97078186199058e-05 NA NA NA hsa-miR-3065-5p MEF2C -0.241623656423063 0.633116553078159 -0.551981334021318 0.0959984642799439 MirTarget;mirMAP -0.189113292537896 6.41072754221867e-05 NA NA NA hsa-miR-32-3p MEF2C 0.583525764322974 0.11837203008551 -0.551981334021318 0.0959984642799439 mirMAP -0.202665963734678 0.00441002655866895 NA NA NA hsa-miR-320b MEF2C 1.11183660885284 0.000497971211648503 -0.551981334021318 0.0959984642799439 miRanda -0.221506916544702 0.00247110841092194 NA NA NA hsa-miR-320c MEF2C 0.455072851945474 0.240613785444485 -0.551981334021318 0.0959984642799439 miRanda -0.200683133593408 0.00450550424447463 NA NA NA hsa-miR-324-3p MEF2C 1.04940352369965 0.000387716796520961 -0.551981334021318 0.0959984642799439 miRNATAP -0.390480462050412 4.67728638423619e-07 NA NA NA hsa-miR-331-5p MEF2C 1.0778596491846 2.79470024753813e-05 -0.551981334021318 0.0959984642799439 PITA -0.286924922411886 0.00155102340912754 NA NA NA hsa-miR-335-3p MEF2C 2.5197689063267 2.20084506976733e-09 -0.551981334021318 0.0959984642799439 MirTarget;mirMAP -0.207862556269377 9.26682408168156e-05 NA NA NA hsa-miR-33a-3p MEF2C 0.347011402017138 0.321709379745392 -0.551981334021318 0.0959984642799439 MirTarget;mirMAP;miRNATAP -0.394593352333097 1.08339942974134e-08 NA NA NA hsa-miR-33b-5p MEF2C 0.267227362818466 0.614814331176942 -0.551981334021318 0.0959984642799439 mirMAP -0.24445509726474 1.66719202524736e-05 NA NA NA hsa-miR-3613-5p MEF2C 1.11821523851438 0.000249706750761735 -0.551981334021318 0.0959984642799439 MirTarget;miRNATAP -0.256232783501154 0.000782732749355042 NA NA NA hsa-miR-425-5p MEF2C 1.13924952403101 0.000255357546232931 -0.551981334021318 0.0959984642799439 MirTarget;miRNATAP -0.21672361425942 0.00386179843895472 NA NA NA hsa-miR-429 MEF2C 1.40182602301928 0.00900426780286475 -0.551981334021318 0.0959984642799439 miRanda;miRNATAP -0.227393718279803 8.41579148790641e-08 NA NA NA hsa-miR-452-5p MEF2C 2.08756506185889 0.000258095769002813 -0.551981334021318 0.0959984642799439 MirTarget;miRNATAP -0.1599072156587 6.89147997814097e-05 NA NA NA hsa-miR-550a-3p MEF2C 2.05849884025997 7.99642185793604e-07 -0.551981334021318 0.0959984642799439 MirTarget -0.232151330603846 0.000119057240193622 NA NA NA hsa-miR-590-3p MEF2C 1.11654983899947 0.000160782154924864 -0.551981334021318 0.0959984642799439 mirMAP -0.24823275848811 0.00164057356712833 NA NA NA hsa-miR-590-5p MEF2C 1.04171442093217 0.000272475544954865 -0.551981334021318 0.0959984642799439 MirTarget;PITA;miRanda;miRNATAP -0.413698066056772 2.28304546151589e-07 NA NA NA hsa-miR-744-3p MEF2C 1.40439584998788 0.000973603203532439 -0.551981334021318 0.0959984642799439 MirTarget;miRNATAP -0.356226144523903 9.76619493541396e-12 NA NA NA hsa-miR-92a-3p MEF2C 1.2209325870225 6.8757197708107e-06 -0.551981334021318 0.0959984642799439 miRNAWalker2_validate -0.498781852906078 1.58523784152157e-09 NA NA NA hsa-miR-940 MEF2C 1.64406174271686 0.000690854900107004 -0.551981334021318 0.0959984642799439 PITA;miRNATAP -0.27379948075115 8.82306039670444e-07 NA NA NA hsa-miR-96-5p MEF2C 1.14243043653372 0.00942969392739105 -0.551981334021318 0.0959984642799439 miRNATAP -0.395604668273327 5.19424575173503e-14 NA NA NA hsa-miR-15a-5p MKNK1 1.03783090449383 7.40334108980898e-07 -0.290705401594514 0.032751345405711 MirTarget -0.171386719752737 0.00013500121972682 NA NA NA hsa-miR-16-5p MKNK1 1.00515772948091 5.33912942007619e-06 -0.290705401594514 0.032751345405711 MirTarget -0.137757031749413 0.00134053245359387 NA NA NA hsa-miR-29a-5p MKNK1 0.585084040404152 0.023014129158495 -0.290705401594514 0.032751345405711 mirMAP -0.118118157663592 0.00158221652031963 NA NA NA hsa-miR-423-5p MKNK1 0.832613878736338 0.000791321227103338 -0.290705401594514 0.032751345405711 miRNATAP -0.135424161296392 0.000422388747099071 NA NA NA hsa-miR-17-5p MKNK2 1.65862087862483 8.45603406215941e-08 -0.962948465285105 0.000220131990703863 MirTarget;TargetScan;miRNATAP -0.178814008522931 0.00237338188680573 NA NA NA hsa-miR-20a-5p MKNK2 1.4503375861709 5.7813456424762e-07 -0.962948465285105 0.000220131990703863 MirTarget;miRNATAP -0.216466150469397 0.00058718480349592 NA NA NA hsa-miR-21-5p MKNK2 1.75445050487988 2.41825549682022e-23 -0.962948465285105 0.000220131990703863 miRNAWalker2_validate -0.45364237213525 1.87419493051414e-06 NA NA NA hsa-miR-335-5p MKNK2 1.59953351087307 5.56170899867314e-05 -0.962948465285105 0.000220131990703863 miRNAWalker2_validate -0.129661433721139 0.00530451097124995 NA NA NA hsa-miR-423-5p MKNK2 0.832613878736338 0.000791321227103338 -0.962948465285105 0.000220131990703863 miRNAWalker2_validate;MirTarget -0.388863185580069 1.38150231920063e-07 NA NA NA hsa-miR-625-5p MKNK2 0.537211086526376 0.203801009380384 -0.962948465285105 0.000220131990703863 MirTarget;mirMAP -0.178575407728267 5.33242231217441e-05 NA NA NA hsa-miR-92a-1-5p MKNK2 1.89098984312485 1.38098912842682e-06 -0.962948465285105 0.000220131990703863 mirMAP -0.14567365121606 0.00176735598296058 NA NA NA hsa-miR-93-5p MKNK2 1.7515174434778 1.59386482413883e-08 -0.962948465285105 0.000220131990703863 MirTarget;miRNATAP -0.201355029864058 0.000556923829102845 NA NA NA hsa-miR-130b-5p MRAS 0.701350393759937 0.0510142718395002 -0.93856327130669 0.01022886035931 mirMAP -0.352489233850365 7.48315963886491e-07 NA NA NA hsa-miR-135b-5p MRAS 4.09156383496059 1.32294295002438e-12 -0.93856327130669 0.01022886035931 miRNATAP -0.207106279307674 6.542401185588e-07 NA NA NA hsa-miR-15a-5p MRAS 1.03783090449383 7.40334108980898e-07 -0.93856327130669 0.01022886035931 miRNATAP -0.434870200897066 0.000401088723644211 NA NA NA hsa-miR-15b-5p MRAS 1.62046407540723 5.42152621571078e-09 -0.93856327130669 0.01022886035931 miRNATAP -0.435414108925877 1.08210708843648e-06 NA NA NA hsa-miR-16-5p MRAS 1.00515772948091 5.33912942007619e-06 -0.93856327130669 0.01022886035931 miRNATAP -0.431323426373678 0.000219744863833023 NA NA NA hsa-miR-182-5p MRAS 0.887369486030646 0.0310640781418789 -0.93856327130669 0.01022886035931 miRNATAP -0.2695020582748 1.60612116167232e-05 NA NA NA hsa-miR-32-3p MRAS 0.583525764322974 0.11837203008551 -0.93856327130669 0.01022886035931 mirMAP -0.327873546858812 2.57190000263241e-05 NA NA NA hsa-miR-330-5p MRAS 0.488365986827708 0.0512207630808233 -0.93856327130669 0.01022886035931 miRanda -0.39855941917819 0.000137455548651093 NA NA NA hsa-miR-335-3p MRAS 2.5197689063267 2.20084506976733e-09 -0.93856327130669 0.01022886035931 mirMAP -0.266508913361864 5.24918701905074e-06 NA NA NA hsa-miR-33a-3p MRAS 0.347011402017138 0.321709379745392 -0.93856327130669 0.01022886035931 mirMAP -0.348087364894607 7.50558044495045e-06 NA NA NA hsa-miR-421 MRAS 1.80720854070385 1.59709651202848e-07 -0.93856327130669 0.01022886035931 miRanda -0.249502867228814 0.000664493612902864 NA NA NA hsa-miR-429 MRAS 1.40182602301928 0.00900426780286475 -0.93856327130669 0.01022886035931 miRanda;miRNATAP -0.303359734134872 5.07340918220063e-11 NA NA NA hsa-miR-652-3p MRAS 1.02742852909286 0.000337974815149397 -0.93856327130669 0.01022886035931 miRNAWalker2_validate -0.463233951112132 1.6097470965954e-07 NA NA NA hsa-miR-7-1-3p MRAS 0.709309110750947 0.0412301737463194 -0.93856327130669 0.01022886035931 mirMAP -0.303513851388767 4.54855158162686e-05 NA NA NA hsa-miR-96-5p MRAS 1.14243043653372 0.00942969392739105 -0.93856327130669 0.01022886035931 TargetScan;miRNATAP -0.288537748500801 2.06964631451897e-06 NA NA NA hsa-let-7g-5p MYC 0.325297685027927 0.241142963826631 0.519157788027723 0.0906694636452631 miRNAWalker2_validate;miRTarBase -0.208004338135784 0.00889968380877331 NA NA NA hsa-miR-26a-5p MYC -0.384110714440647 0.0442498636014044 0.519157788027723 0.0906694636452631 miRNAWalker2_validate -0.595250601703361 1.86863162610225e-07 21901171 Our results identify new molecular targets of c-Myc in AML and highlight miR-26a attractiveness as a therapeutic target in leukemia acute myeloid leukemia hsa-miR-335-5p MYC 1.59953351087307 5.56170899867314e-05 0.519157788027723 0.0906694636452631 miRNAWalker2_validate -0.211331388667708 7.8766835557931e-05 NA NA NA hsa-miR-34a-5p MYC 0.794251341270032 0.00024017386701179 0.519157788027723 0.0906694636452631 miRNAWalker2_validate;miRTarBase -0.342899797750895 0.000672118391671011 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-423-5p MYC 0.832613878736338 0.000791321227103338 0.519157788027723 0.0906694636452631 miRNAWalker2_validate -0.242528994449528 0.00588609161419062 NA NA NA hsa-miR-193b-3p NF1 0.281752012268679 0.451258902263119 0.296660298716273 0.141340363425621 miRNAWalker2_validate -0.139046924141261 0.000256494343862068 NA NA NA hsa-miR-27a-3p NF1 1.29886998470345 2.68986118553486e-08 0.296660298716273 0.141340363425621 MirTarget -0.184606843234685 0.00196035817935508 NA NA NA hsa-miR-27b-3p NF1 0.0836323965901755 0.725273923274 0.296660298716273 0.141340363425621 MirTarget -0.16412670011364 0.00718453960999936 NA NA NA hsa-miR-127-3p NFATC2 0.211466568760589 0.46101284760949 -1.59961056631546 0.00281133641536435 miRanda -0.440934200254586 0.00108125584988915 NA NA NA hsa-miR-16-2-3p NFATC2 1.8048179609245 2.83095715136409e-09 -1.59961056631546 0.00281133641536435 mirMAP -0.41125270241114 0.000715298865948725 NA NA NA hsa-miR-182-5p NFATC2 0.887369486030646 0.0310640781418789 -1.59961056631546 0.00281133641536435 mirMAP -0.567269109312586 2.24367951120668e-10 NA NA NA hsa-miR-185-5p NFATC2 1.14351510556643 1.07346945085714e-08 -1.59961056631546 0.00281133641536435 MirTarget -0.499817944481714 0.00828802674325368 NA NA NA hsa-miR-193b-5p NFATC2 0.609581100028941 0.13923921336815 -1.59961056631546 0.00281133641536435 MirTarget -0.680714524641957 6.25001943324036e-15 NA NA NA hsa-miR-214-3p NFATC2 1.01201534142544 0.00625092909225755 -1.59961056631546 0.00281133641536435 MirTarget;miRNATAP -0.346814100487716 0.000754388476626183 NA NA NA hsa-miR-218-5p NFATC2 -0.987730614742492 0.0108295837207062 -1.59961056631546 0.00281133641536435 MirTarget -0.282440161682966 0.00423199266169878 NA NA NA hsa-miR-2355-3p NFATC2 0.982963823342009 0.0229275810851348 -1.59961056631546 0.00281133641536435 mirMAP -0.453847272998389 2.46446985195066e-07 NA NA NA hsa-miR-2355-5p NFATC2 0.594869787574182 0.120591076715177 -1.59961056631546 0.00281133641536435 MirTarget -0.532848310106599 4.91423365542074e-08 NA NA NA hsa-miR-24-3p NFATC2 1.08578167539644 6.18549359075268e-07 -1.59961056631546 0.00281133641536435 MirTarget -1.45254338985393 6.04651769391668e-20 NA NA NA hsa-miR-27b-5p NFATC2 0.680479953627235 0.0149700717026754 -1.59961056631546 0.00281133641536435 mirMAP -0.42316502419689 0.00212327014131092 NA NA NA hsa-miR-31-3p NFATC2 0.474904754927656 0.506866261575484 -1.59961056631546 0.00281133641536435 MirTarget -0.195566940204306 0.000270542724131413 NA NA NA hsa-miR-33a-3p NFATC2 0.347011402017138 0.321709379745392 -1.59961056631546 0.00281133641536435 mirMAP -0.338506549372764 0.00353062499167457 NA NA NA hsa-miR-452-5p NFATC2 2.08756506185889 0.000258095769002813 -1.59961056631546 0.00281133641536435 MirTarget;miRNATAP -0.5820965937005 9.37316214675739e-23 NA NA NA hsa-miR-493-5p NFATC2 0.962900723235399 0.00324541076496571 -1.59961056631546 0.00281133641536435 miRNATAP -0.394683188595673 0.000708478667902983 NA NA NA hsa-miR-9-5p NFATC2 -0.195328736653048 0.761470692992178 -1.59961056631546 0.00281133641536435 MirTarget -0.266371368646787 5.74817715985005e-06 NA NA NA hsa-miR-1254 NFATC4 0.941374574140312 0.0605480748500796 -0.980763910174937 0.0029209022426907 MirTarget -0.215727047297164 0.000122900719889012 NA NA NA hsa-miR-130b-5p NFATC4 0.701350393759937 0.0510142718395002 -0.980763910174937 0.0029209022426907 mirMAP -0.201332024330862 0.00216102171564684 NA NA NA hsa-miR-15b-3p NFATC4 1.75738933306437 3.00554466232543e-08 -0.980763910174937 0.0029209022426907 mirMAP -0.402069412766773 8.91984604542673e-09 NA NA NA hsa-miR-185-3p NFATC4 1.33711019171256 3.45756583967985e-05 -0.980763910174937 0.0029209022426907 MirTarget -0.314816627269359 9.37036160600659e-06 NA NA NA hsa-miR-29b-3p NFATC4 -0.230693226193598 0.367461626035234 -0.980763910174937 0.0029209022426907 miRNATAP -0.26970494128862 0.00391795610199839 NA NA NA hsa-miR-320a NFATC4 0.593888711838028 0.011897419390526 -0.980763910174937 0.0029209022426907 miRanda;mirMAP -0.351342242860151 0.000468865306104097 NA NA NA hsa-miR-320b NFATC4 1.11183660885284 0.000497971211648503 -0.980763910174937 0.0029209022426907 miRanda;mirMAP -0.332027993771327 4.22472900238734e-06 NA NA NA hsa-miR-320c NFATC4 0.455072851945474 0.240613785444485 -0.980763910174937 0.0029209022426907 miRanda;mirMAP -0.234195633885622 0.00089352283684434 NA NA NA hsa-miR-361-3p NFATC4 -0.126462931388735 0.566052688733137 -0.980763910174937 0.0029209022426907 mirMAP -0.336766197694243 0.00204561584110053 NA NA NA hsa-miR-429 NFATC4 1.40182602301928 0.00900426780286475 -0.980763910174937 0.0029209022426907 miRNATAP -0.207303237402496 1.27015716066244e-06 NA NA NA hsa-miR-484 NFATC4 0.71327898984355 0.00233605130771196 -0.980763910174937 0.0029209022426907 MirTarget;miRNATAP -0.492753812629456 6.90322701785734e-07 NA NA NA hsa-miR-625-5p NFATC4 0.537211086526376 0.203801009380384 -0.980763910174937 0.0029209022426907 mirMAP -0.159316378849634 0.00460664291026236 NA NA NA hsa-miR-629-3p NFATC4 1.40326397107309 9.7803063526732e-05 -0.980763910174937 0.0029209022426907 mirMAP -0.283244907446903 8.72915740660251e-06 NA NA NA hsa-miR-940 NFATC4 1.64406174271686 0.000690854900107004 -0.980763910174937 0.0029209022426907 miRNATAP -0.188985957537193 0.000863191691433627 NA NA NA hsa-miR-193b-3p NFKB2 0.281752012268679 0.451258902263119 0.778708961867254 0.000948243711376175 miRNAWalker2_validate -0.133992722747741 0.00308999859304072 NA NA NA hsa-let-7f-5p NGF 0.634633924115866 0.0344982923411787 -0.0044354260251589 0.994557609636983 MirTarget -0.455658818520987 0.00313618077968416 NA NA NA hsa-let-7g-5p NGF 0.325297685027927 0.241142963826631 -0.0044354260251589 0.994557609636983 MirTarget -0.833551967281976 3.8902528304102e-07 NA NA NA hsa-miR-423-5p NGF 0.832613878736338 0.000791321227103338 -0.0044354260251589 0.994557609636983 MirTarget;miRNATAP -0.706016056377721 0.0001322029752225 NA NA NA hsa-miR-429 NGF 1.40182602301928 0.00900426780286475 -0.0044354260251589 0.994557609636983 miRanda -0.396695496445767 2.17739891550587e-06 NA NA NA hsa-let-7a-2-3p NLK 0.195895719455896 0.643556335039042 0.0865156889877525 0.609407030612974 MirTarget -0.115780513854402 4.46095204310792e-05 NA NA NA hsa-let-7b-5p NLK 0.0582902155815681 0.781400138984745 0.0865156889877525 0.609407030612974 miRNATAP -0.270395273786971 2.08007261235126e-06 NA NA NA hsa-miR-125a-3p NLK 1.19506542853853 0.00164364545717311 0.0865156889877525 0.609407030612974 MirTarget;PITA;miRanda;miRNATAP -0.109624735092585 0.000457841130996044 NA NA NA hsa-miR-152-3p NLK 0.436002345388935 0.161701199884702 0.0865156889877525 0.609407030612974 MirTarget -0.239519951117593 7.72311978981534e-11 NA NA NA hsa-miR-199a-3p NLK 0.85352674491639 0.000360518331912285 0.0865156889877525 0.609407030612974 MirTarget;PITA;miRNATAP -0.209099788244277 2.11023276832068e-05 24972723 NLK a novel target of miR 199a 3p functions as a tumor suppressor in colorectal cancer; In our present study we demonstrated miR-199a-3p could directly target 3'-UTR of NLK gene by luciferase reporter assay and western blot analysis; All these results suggested that NLK was an identified miR-199a-3p target gene and functioned as a tumor suppressor gene in colorectal cancer colorectal cancer hsa-miR-199a-5p NLK 0.371973504507027 0.232661597228763 0.0865156889877525 0.609407030612974 MirTarget;PITA;miRanda;miRNATAP -0.107729191052632 0.00511751234523467 24972723 NLK a novel target of miR 199a 3p functions as a tumor suppressor in colorectal cancer colorectal cancer hsa-miR-199b-3p NLK 0.860968252593043 0.00032297319521262 0.0865156889877525 0.609407030612974 MirTarget;PITA;miRNATAP -0.209350432570596 2.02137346929793e-05 NA NA NA hsa-miR-23a-3p NLK 1.10685926969665 3.16223452471768e-08 0.0865156889877525 0.609407030612974 miRNAWalker2_validate;MirTarget -0.318308110916336 2.3278905952491e-08 NA NA NA hsa-miR-23b-3p NLK -0.286465516491361 0.18664668472995 0.0865156889877525 0.609407030612974 MirTarget -0.331173047788756 8.08816350783218e-10 NA NA NA hsa-miR-24-3p NLK 1.08578167539644 6.18549359075268e-07 0.0865156889877525 0.609407030612974 miRNATAP -0.308198936110474 3.72156001183611e-09 NA NA NA hsa-miR-27a-3p NLK 1.29886998470345 2.68986118553486e-08 0.0865156889877525 0.609407030612974 miRNATAP -0.291004775010687 1.44042928428653e-09 NA NA NA hsa-miR-27b-3p NLK 0.0836323965901755 0.725273923274 0.0865156889877525 0.609407030612974 miRNATAP -0.357651018744201 8.68529693059433e-14 NA NA NA hsa-miR-28-5p NLK -0.238617853755144 0.167318538669818 0.0865156889877525 0.609407030612974 miRanda -0.246127435966616 0.000525486006383019 NA NA NA hsa-miR-342-3p NLK 0.318119432680668 0.269150960124243 0.0865156889877525 0.609407030612974 miRanda -0.111055975263123 0.00788801180777459 NA NA NA hsa-let-7c-5p NRAS -0.503482361446512 0.206848395212976 0.606733058105388 0.0107700909176788 miRNAWalker2_validate;miRTarBase;MirTarget -0.124225168269858 0.00351586115791848 NA NA NA hsa-miR-145-5p NRAS -1.75133578902314 1.54965572197748e-05 0.606733058105388 0.0107700909176788 miRNAWalker2_validate;MirTarget;miRNATAP -0.113590801226011 0.00562715254109734 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-26a-5p NRAS -0.384110714440647 0.0442498636014044 0.606733058105388 0.0107700909176788 mirMAP;miRNATAP -0.253407088765911 0.00536728320880026 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-28-5p NRAS -0.238617853755144 0.167318538669818 0.606733058105388 0.0107700909176788 MirTarget;PITA;miRanda;miRNATAP -0.309483366881585 0.00227879779800337 NA NA NA hsa-miR-29c-3p NRAS -1.62454036584589 5.38376515586029e-07 0.606733058105388 0.0107700909176788 miRNATAP -0.175997480071788 0.000530133170369644 NA NA NA hsa-miR-21-5p NTF3 1.75445050487988 2.41825549682022e-23 -1.62090037978398 0.0028979647870912 miRTarBase;miRNATAP -0.654434459929646 0.00114877436972271 NA NA NA hsa-miR-107 NTRK2 0.904627575346218 4.67936495073904e-05 0.129052700235785 0.904324328702051 PITA;miRanda -1.24910626177656 0.00024341170686849 NA NA NA hsa-miR-140-3p NTRK2 -0.296251775392129 0.127539826012144 0.129052700235785 0.904324328702051 PITA -1.43629375239255 0.000327819599110366 NA NA NA hsa-miR-148a-5p NTRK2 -0.69329616490858 0.0793012233740369 0.129052700235785 0.904324328702051 mirMAP -0.62690136997922 0.00111999270999755 NA NA NA hsa-miR-186-5p NTRK2 0.149964130725901 0.434709542998771 0.129052700235785 0.904324328702051 mirMAP -1.53387891250486 0.000154763882037282 NA NA NA hsa-miR-29a-5p NTRK2 0.585084040404152 0.023014129158495 0.129052700235785 0.904324328702051 mirMAP -1.1189889083857 0.000158182837179273 NA NA NA hsa-miR-30d-3p NTRK2 -0.545113326540761 0.0433733076874155 0.129052700235785 0.904324328702051 mirMAP -0.840024189446887 0.00314885294170295 NA NA NA hsa-miR-30d-5p NTRK2 -0.5492586056147 0.0140125082460125 0.129052700235785 0.904324328702051 mirMAP -1.08205944732444 0.00168936814844951 NA NA NA hsa-miR-326 NTRK2 -0.429748586406214 0.2629894124021 0.129052700235785 0.904324328702051 miRanda -1.0084031919731 2.97462223495207e-07 NA NA NA hsa-miR-330-5p NTRK2 0.488365986827708 0.0512207630808233 0.129052700235785 0.904324328702051 miRanda -1.10006559956903 0.000320304929154941 NA NA NA hsa-miR-335-5p NTRK2 1.59953351087307 5.56170899867314e-05 0.129052700235785 0.904324328702051 miRNAWalker2_validate -0.554413660240109 0.00332406257269656 NA NA NA hsa-miR-338-3p NTRK2 -0.959276231066179 0.0191473351014091 0.129052700235785 0.904324328702051 miRanda -1.15537671088924 7.88265095662026e-11 NA NA NA hsa-miR-362-5p NTRK2 -0.354508685915981 0.354912078595613 0.129052700235785 0.904324328702051 mirMAP -0.973937329266648 6.24360566263495e-07 NA NA NA hsa-miR-501-5p NTRK2 0.266919328110625 0.454779001968586 0.129052700235785 0.904324328702051 mirMAP -1.02102960533135 1.21803450026443e-06 NA NA NA hsa-miR-532-5p NTRK2 0.313080805824184 0.252248939356301 0.129052700235785 0.904324328702051 PITA -1.59975014566445 4.3572070168858e-09 NA NA NA hsa-miR-577 NTRK2 0.911619788986754 0.2256062124148 0.129052700235785 0.904324328702051 mirMAP -0.449281370294781 1.07363179810198e-05 NA NA NA hsa-miR-139-5p PAK2 -1.83374360776637 1.22019901002824e-09 0.662056960095314 0.000235218579429093 MirTarget;miRanda -0.163967640643715 5.67597969950761e-05 NA NA NA hsa-miR-140-3p PAK2 -0.296251775392129 0.127539826012144 0.662056960095314 0.000235218579429093 MirTarget;PITA;miRNATAP -0.31081143169999 3.34260300865615e-06 NA NA NA hsa-miR-148a-5p PAK2 -0.69329616490858 0.0793012233740369 0.662056960095314 0.000235218579429093 MirTarget -0.108048782178219 0.000890424208827977 NA NA NA hsa-miR-26a-5p PAK2 -0.384110714440647 0.0442498636014044 0.662056960095314 0.000235218579429093 MirTarget;miRNATAP -0.273452376375985 6.54442373840941e-05 NA NA NA hsa-let-7a-3p PDGFRA 0.503048155002889 0.0411145454335299 -1.16052455489929 0.00469457800041433 mirMAP -0.408353851698219 0.000676900473184116 NA NA NA hsa-let-7b-3p PDGFRA 0.21838629112113 0.296038413622566 -1.16052455489929 0.00469457800041433 mirMAP -0.396878610010639 0.00585973151537375 NA NA NA hsa-let-7b-5p PDGFRA 0.0582902155815681 0.781400138984745 -1.16052455489929 0.00469457800041433 miRNAWalker2_validate -0.476383510169118 0.000849680543371195 NA NA NA hsa-let-7f-1-3p PDGFRA 1.28704406797397 1.17954701106157e-06 -1.16052455489929 0.00469457800041433 mirMAP -0.510677857296601 1.86478326712873e-06 NA NA NA hsa-let-7g-3p PDGFRA 0.64979533805273 0.0103084600883006 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.427053544147745 0.000232980860387631 NA NA NA hsa-miR-106b-5p PDGFRA 1.70863907461894 2.04074794107142e-08 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.309529989101084 0.000900259038001664 NA NA NA hsa-miR-130b-3p PDGFRA 1.32714007211004 4.78676252285191e-05 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.323034116833204 0.000252646518119505 NA NA NA hsa-miR-141-3p PDGFRA 1.45548825076434 0.00115958850961764 -1.16052455489929 0.00469457800041433 MirTarget -0.272935688822065 2.05225184731917e-05 NA NA NA hsa-miR-149-5p PDGFRA 0.706277554734069 0.296848731347677 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.204884142254506 1.43284462144315e-06 NA NA NA hsa-miR-16-1-3p PDGFRA 1.43227522002564 3.70920454953168e-08 -1.16052455489929 0.00469457800041433 MirTarget -0.386511551403792 0.000421130307898712 NA NA NA hsa-miR-17-5p PDGFRA 1.65862087862483 8.45603406215941e-08 -1.16052455489929 0.00469457800041433 MirTarget;TargetScan;miRNATAP -0.356393358462224 9.88240800111174e-05 NA NA NA hsa-miR-182-5p PDGFRA 0.887369486030646 0.0310640781418789 -1.16052455489929 0.00469457800041433 miRNATAP -0.360773153367445 2.16793167252092e-07 NA NA NA hsa-miR-196a-5p PDGFRA 6.59255881689547 1.53691144193899e-22 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.111949684332786 0.00385048520276526 NA NA NA hsa-miR-196b-5p PDGFRA 5.58954708296963 1.12099152907987e-19 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.130835032420459 0.00238656958843899 NA NA NA hsa-miR-20a-5p PDGFRA 1.4503375861709 5.7813456424762e-07 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.290949630098886 0.00333304913306046 NA NA NA hsa-miR-219a-5p PDGFRA 0.605535434887599 0.0854495887591817 -1.16052455489929 0.00469457800041433 MirTarget -0.334702476451174 5.59649998290824e-05 NA NA NA hsa-miR-224-5p PDGFRA 2.7648036144402 0.000111736336240167 -1.16052455489929 0.00469457800041433 MirTarget -0.202264857356356 2.7344531322204e-07 NA NA NA hsa-miR-24-3p PDGFRA 1.08578167539644 6.18549359075268e-07 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.80542708487755 3.49721401699797e-10 NA NA NA hsa-miR-27a-3p PDGFRA 1.29886998470345 2.68986118553486e-08 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.749473123725816 2.3288170404456e-10 NA NA NA hsa-miR-27b-3p PDGFRA 0.0836323965901755 0.725273923274 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.502143905481073 5.44941103065583e-05 NA NA NA hsa-miR-301a-3p PDGFRA 1.44721900431161 6.35068481036652e-06 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.240717213465514 0.00761366951584292 NA NA NA hsa-miR-3065-5p PDGFRA -0.241623656423063 0.633116553078159 -1.16052455489929 0.00469457800041433 mirMAP -0.154613330078393 0.00962944858215771 NA NA NA hsa-miR-330-5p PDGFRA 0.488365986827708 0.0512207630808233 -1.16052455489929 0.00469457800041433 miRanda -0.311345692720835 0.00879331340845444 NA NA NA hsa-miR-335-3p PDGFRA 2.5197689063267 2.20084506976733e-09 -1.16052455489929 0.00469457800041433 mirMAP -0.180474779188923 0.00708107448376463 NA NA NA hsa-miR-33a-5p PDGFRA 0.407757858040717 0.321429014317207 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.38674069592567 2.76867912009244e-08 NA NA NA hsa-miR-33b-5p PDGFRA 0.267227362818466 0.614814331176942 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.330006551788421 2.87405240493235e-06 NA NA NA hsa-miR-34c-5p PDGFRA 2.20632574870337 0.000379662996168678 -1.16052455489929 0.00469457800041433 MirTarget;PITA;miRanda;miRNATAP -0.121772445130468 0.00965103598609489 NA NA NA hsa-miR-590-5p PDGFRA 1.04171442093217 0.000272475544954865 -1.16052455489929 0.00469457800041433 miRanda -0.480670069602324 1.60944318294763e-06 NA NA NA hsa-miR-93-5p PDGFRA 1.7515174434778 1.59386482413883e-08 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.257971477859351 0.00500909640090511 NA NA NA hsa-miR-944 PDGFRA 3.33123095809751 0.0177835044930391 -1.16052455489929 0.00469457800041433 mirMAP -0.137440077961584 9.05523929015606e-09 NA NA NA hsa-miR-96-5p PDGFRA 1.14243043653372 0.00942969392739105 -1.16052455489929 0.00469457800041433 TargetScan;miRNATAP -0.367778743049386 5.89709579941633e-08 NA NA NA hsa-miR-3127-5p PDGFRB 0.98677589413294 0.00734249049849 0.844690963059587 0.0248980975397874 mirMAP -0.216339467888686 0.00297551716216838 NA NA NA hsa-miR-664a-3p PDGFRB -0.83041219170254 0.000136267547251167 0.844690963059587 0.0248980975397874 MirTarget -0.351564932871264 0.00450301463469565 NA NA NA hsa-miR-142-5p PLA2G12A 1.55592486377018 6.69269968016779e-06 -0.897976387208921 3.92439583608381e-08 mirMAP -0.120071229648663 0.000364039582551817 NA NA NA hsa-miR-16-2-3p PLA2G12A 1.8048179609245 2.83095715136409e-09 -0.897976387208921 3.92439583608381e-08 mirMAP -0.13547544045603 0.000324052648114578 NA NA NA hsa-let-7g-5p PLA2G3 0.325297685027927 0.241142963826631 1.08081143630036 0.274800614063828 MirTarget -0.713843300957369 0.00535751699457478 NA NA NA hsa-miR-338-3p PLA2G3 -0.959276231066179 0.0191473351014091 1.08081143630036 0.274800614063828 MirTarget;miRanda;miRNATAP -0.599759722990571 0.000430611134352631 NA NA NA hsa-miR-592 PLA2G3 0.779567202789068 0.204498177014474 1.08081143630036 0.274800614063828 miRNATAP -0.323513783396214 0.00859092346414437 NA NA NA hsa-miR-128-3p PLA2G5 0.98280381420517 5.77641850797209e-05 -1.41308234162024 0.0225473078256035 miRNAWalker2_validate -0.905295305603834 2.75117618540628e-07 NA NA NA hsa-miR-330-5p PLA2G5 0.488365986827708 0.0512207630808233 -1.41308234162024 0.0225473078256035 miRanda -0.926413267320503 1.02011927893847e-07 NA NA NA hsa-miR-339-5p PLA2G5 0.770566566962108 0.00816529093411862 -1.41308234162024 0.0225473078256035 miRanda -0.723615809585887 1.23466479069586e-06 NA NA NA hsa-miR-429 PLA2G5 1.40182602301928 0.00900426780286475 -1.41308234162024 0.0225473078256035 miRanda -0.548400833208393 1.57333799329149e-12 NA NA NA hsa-miR-589-3p PLA2G5 1.01962606923682 0.00577853347252709 -1.41308234162024 0.0225473078256035 MirTarget -0.574409018016161 8.84241947286267e-07 NA NA NA hsa-miR-590-3p PLA2G5 1.11654983899947 0.000160782154924864 -1.41308234162024 0.0225473078256035 miRanda;miRNATAP -0.733311626897206 4.33156195650278e-07 NA NA NA hsa-miR-590-5p PLA2G5 1.04171442093217 0.000272475544954865 -1.41308234162024 0.0225473078256035 miRanda -0.821191810458237 3.9237270066779e-08 NA NA NA hsa-let-7f-1-3p PPM1A 1.28704406797397 1.17954701106157e-06 -0.485134207243171 0.00196241753798567 MirTarget -0.168437359301639 3.74086299216888e-05 NA NA NA hsa-let-7g-3p PPM1A 0.64979533805273 0.0103084600883006 -0.485134207243171 0.00196241753798567 miRNATAP -0.143080603484488 0.00117837240468153 NA NA NA hsa-miR-106b-5p PPM1A 1.70863907461894 2.04074794107142e-08 -0.485134207243171 0.00196241753798567 mirMAP -0.238512692491357 1.22827939352649e-12 NA NA NA hsa-miR-107 PPM1A 0.904627575346218 4.67936495073904e-05 -0.485134207243171 0.00196241753798567 miRanda -0.313778994621332 5.67240079960165e-11 NA NA NA hsa-miR-126-5p PPM1A 0.41765430251855 0.0753161203651532 -0.485134207243171 0.00196241753798567 mirMAP -0.264839645978736 1.34497577907486e-08 NA NA NA hsa-miR-140-3p PPM1A -0.296251775392129 0.127539826012144 -0.485134207243171 0.00196241753798567 miRNATAP -0.281706080970431 9.899709199033e-07 NA NA NA hsa-miR-142-5p PPM1A 1.55592486377018 6.69269968016779e-06 -0.485134207243171 0.00196241753798567 mirMAP -0.182768222503608 2.07238763583069e-09 NA NA NA hsa-miR-146b-3p PPM1A 1.10138643500522 3.66835580263893e-05 -0.485134207243171 0.00196241753798567 miRNATAP -0.117415406326079 0.00452636659933672 NA NA NA hsa-miR-146b-5p PPM1A 1.547491371264 6.06614361290688e-08 -0.485134207243171 0.00196241753798567 miRanda;miRNATAP -0.109344171784543 0.00395047401448269 NA NA NA hsa-miR-148a-5p PPM1A -0.69329616490858 0.0793012233740369 -0.485134207243171 0.00196241753798567 mirMAP -0.124555591584755 7.18569962930991e-06 NA NA NA hsa-miR-15b-5p PPM1A 1.62046407540723 5.42152621571078e-09 -0.485134207243171 0.00196241753798567 MirTarget;miRNATAP -0.156119731946374 4.81367650144137e-05 NA NA NA hsa-miR-16-1-3p PPM1A 1.43227522002564 3.70920454953168e-08 -0.485134207243171 0.00196241753798567 mirMAP -0.157298417951464 0.000144517049009266 NA NA NA hsa-miR-16-5p PPM1A 1.00515772948091 5.33912942007619e-06 -0.485134207243171 0.00196241753798567 MirTarget;miRNATAP -0.24858829831728 3.87765239381607e-07 NA NA NA hsa-miR-186-5p PPM1A 0.149964130725901 0.434709542998771 -0.485134207243171 0.00196241753798567 mirMAP;miRNATAP -0.264599681836848 6.67970649389741e-06 NA NA NA hsa-miR-26b-5p PPM1A -0.301646326928219 0.160081421968103 -0.485134207243171 0.00196241753798567 mirMAP -0.228364922998407 1.19361165657603e-05 NA NA NA hsa-miR-32-3p PPM1A 0.583525764322974 0.11837203008551 -0.485134207243171 0.00196241753798567 mirMAP -0.151264793126 4.775899040779e-06 NA NA NA hsa-miR-320a PPM1A 0.593888711838028 0.011897419390526 -0.485134207243171 0.00196241753798567 miRanda -0.141634441486294 0.00290423717552022 NA NA NA hsa-miR-320b PPM1A 1.11183660885284 0.000497971211648503 -0.485134207243171 0.00196241753798567 miRanda -0.162860279434956 1.61371902772e-06 NA NA NA hsa-miR-335-3p PPM1A 2.5197689063267 2.20084506976733e-09 -0.485134207243171 0.00196241753798567 mirMAP -0.110800855609506 9.11933207427903e-06 NA NA NA hsa-miR-340-5p PPM1A -0.164941927483643 0.529910509321278 -0.485134207243171 0.00196241753798567 mirMAP -0.190053652828019 7.05309311204758e-06 NA NA NA hsa-miR-34a-5p PPM1A 0.794251341270032 0.00024017386701179 -0.485134207243171 0.00196241753798567 miRNATAP -0.142969381134978 0.00572300655678839 NA NA NA hsa-miR-361-5p PPM1A 0.407725414130987 0.0181260969156347 -0.485134207243171 0.00196241753798567 miRanda -0.194980898845453 0.00334054133966832 NA NA NA hsa-miR-3613-5p PPM1A 1.11821523851438 0.000249706750761735 -0.485134207243171 0.00196241753798567 miRNATAP -0.173186095194849 1.03403548925692e-06 NA NA NA hsa-miR-421 PPM1A 1.80720854070385 1.59709651202848e-07 -0.485134207243171 0.00196241753798567 miRanda -0.130269897922156 2.63807184636021e-05 NA NA NA hsa-miR-424-5p PPM1A 1.08509868581983 0.000420473853818268 -0.485134207243171 0.00196241753798567 MirTarget;miRNATAP -0.141355037486528 7.11317214994762e-05 NA NA NA hsa-miR-484 PPM1A 0.71327898984355 0.00233605130771196 -0.485134207243171 0.00196241753798567 miRNAWalker2_validate -0.192180663150895 4.82927777995864e-05 NA NA NA hsa-miR-532-5p PPM1A 0.313080805824184 0.252248939356301 -0.485134207243171 0.00196241753798567 miRNATAP -0.146163887826649 0.00035309616791792 NA NA NA hsa-miR-542-3p PPM1A 0.757649022262991 0.00210575463285599 -0.485134207243171 0.00196241753798567 MirTarget -0.145319811411478 0.00131419466511095 NA NA NA hsa-miR-590-3p PPM1A 1.11654983899947 0.000160782154924864 -0.485134207243171 0.00196241753798567 miRanda;mirMAP -0.177567162266042 1.21571241250928e-06 NA NA NA hsa-miR-590-5p PPM1A 1.04171442093217 0.000272475544954865 -0.485134207243171 0.00196241753798567 miRanda -0.155874423222849 4.59623548775572e-05 NA NA NA hsa-miR-7-1-3p PPM1A 0.709309110750947 0.0412301737463194 -0.485134207243171 0.00196241753798567 mirMAP -0.146683508337989 3.25820003981121e-06 NA NA NA hsa-let-7b-3p PPM1B 0.21838629112113 0.296038413622566 -0.0689267959676956 0.554435416645863 mirMAP -0.173069883999124 9.46068125000981e-06 NA NA NA hsa-miR-106b-5p PPP3CA 1.70863907461894 2.04074794107142e-08 -0.311261735064956 0.0874904847441977 miRNATAP -0.177382254092271 1.11662949783484e-05 NA NA NA hsa-miR-142-5p PPP3CA 1.55592486377018 6.69269968016779e-06 -0.311261735064956 0.0874904847441977 PITA;mirMAP;miRNATAP -0.110997481793963 0.00234330425678312 NA NA NA hsa-miR-340-5p PPP3CA -0.164941927483643 0.529910509321278 -0.311261735064956 0.0874904847441977 mirMAP -0.181573032833897 0.000232248398119678 NA NA NA hsa-miR-361-5p PPP3CA 0.407725414130987 0.0181260969156347 -0.311261735064956 0.0874904847441977 miRanda -0.225189217128007 0.0033708826866865 NA NA NA hsa-miR-374b-3p PPP3CA 0.999491658196932 0.00126937019814872 -0.311261735064956 0.0874904847441977 MirTarget -0.164661177292416 0.000153667800685453 NA NA NA hsa-miR-590-5p PPP3CA 1.04171442093217 0.000272475544954865 -0.311261735064956 0.0874904847441977 PITA;miRanda;miRNATAP -0.120747875637189 0.00696948367873323 NA NA NA hsa-miR-940 PPP3CA 1.64406174271686 0.000690854900107004 -0.311261735064956 0.0874904847441977 miRNATAP -0.111531019863646 0.000298626343209584 NA NA NA hsa-miR-107 PPP3CB 0.904627575346218 4.67936495073904e-05 -0.544004942139345 9.04819078192179e-05 miRanda -0.142015238506317 0.00140035242278882 NA NA NA hsa-miR-15a-5p PPP3CB 1.03783090449383 7.40334108980898e-07 -0.544004942139345 9.04819078192179e-05 miRNATAP -0.163057694878539 0.000473345260508312 NA NA NA hsa-miR-15b-5p PPP3CB 1.62046407540723 5.42152621571078e-09 -0.544004942139345 9.04819078192179e-05 miRNATAP -0.186954475055184 2.5872809097186e-08 NA NA NA hsa-miR-16-5p PPP3CB 1.00515772948091 5.33912942007619e-06 -0.544004942139345 9.04819078192179e-05 miRNATAP -0.20524854257795 2.83538301027824e-06 NA NA NA hsa-miR-20a-3p PPP3CB 1.13957127410163 0.000451087640268489 -0.544004942139345 9.04819078192179e-05 miRNATAP -0.125773580763174 2.60598588386373e-05 NA NA NA hsa-miR-339-5p PPP3CB 0.770566566962108 0.00816529093411862 -0.544004942139345 9.04819078192179e-05 miRanda -0.140550747992229 3.00402583828723e-05 NA NA NA hsa-miR-7-1-3p PPP3CB 0.709309110750947 0.0412301737463194 -0.544004942139345 9.04819078192179e-05 mirMAP -0.112769612670814 6.65442420729316e-05 NA NA NA hsa-miR-101-3p PPP3R1 -0.451263906815861 0.0283387250173031 0.365031614184003 0.00208633293716482 miRNATAP -0.129816071813413 0.00164042594155264 NA NA NA hsa-miR-26a-5p PPP3R1 -0.384110714440647 0.0442498636014044 0.365031614184003 0.00208633293716482 MirTarget;miRNATAP -0.142127049894375 0.00146987441972325 NA NA NA hsa-miR-625-5p PRKACA 0.537211086526376 0.203801009380384 -0.0978746557285595 0.44498806360937 MirTarget -0.131652673177358 1.09755795457608e-10 NA NA NA hsa-let-7f-1-3p PRKACB 1.28704406797397 1.17954701106157e-06 -2.00320334289066 3.9598668244402e-09 MirTarget;mirMAP -0.314793266126612 0.000724594726922014 NA NA NA hsa-miR-141-3p PRKACB 1.45548825076434 0.00115958850961764 -2.00320334289066 3.9598668244402e-09 MirTarget;TargetScan;miRNATAP -0.197564834301336 0.000353082319368401 NA NA NA hsa-miR-146b-5p PRKACB 1.547491371264 6.06614361290688e-08 -2.00320334289066 3.9598668244402e-09 miRanda -0.225282836158709 0.00882894958009726 NA NA NA hsa-miR-16-2-3p PRKACB 1.8048179609245 2.83095715136409e-09 -2.00320334289066 3.9598668244402e-09 mirMAP -0.306924849458949 0.000109522279734088 NA NA NA hsa-miR-17-5p PRKACB 1.65862087862483 8.45603406215941e-08 -2.00320334289066 3.9598668244402e-09 TargetScan -0.352359251315541 6.11316064096321e-06 NA NA NA hsa-miR-183-5p PRKACB 1.65900927871187 0.000522025364980187 -2.00320334289066 3.9598668244402e-09 MirTarget -0.181167666603194 0.000458522643446536 NA NA NA hsa-miR-18a-5p PRKACB 2.20211504140984 1.78678887916334e-09 -2.00320334289066 3.9598668244402e-09 miRNATAP -0.316335887919593 1.04839236101925e-06 NA NA NA hsa-miR-200c-3p PRKACB 1.28185685499076 0.00369777635539177 -2.00320334289066 3.9598668244402e-09 MirTarget;miRNATAP -0.207576946884606 0.000221208096678535 NA NA NA hsa-miR-2110 PRKACB 0.759864042760204 0.0723961390557655 -2.00320334289066 3.9598668244402e-09 MirTarget -0.183383468055812 0.00233810067736044 NA NA NA hsa-miR-330-3p PRKACB 0.798460296022179 0.00746538156533435 -2.00320334289066 3.9598668244402e-09 MirTarget -0.302274508758057 0.000317953568855911 NA NA NA hsa-miR-361-5p PRKACB 0.407725414130987 0.0181260969156347 -2.00320334289066 3.9598668244402e-09 miRanda -0.504068079086418 0.000769646776305189 NA NA NA hsa-miR-421 PRKACB 1.80720854070385 1.59709651202848e-07 -2.00320334289066 3.9598668244402e-09 PITA;miRanda -0.335137675315492 1.50625671113954e-06 NA NA NA hsa-miR-590-5p PRKACB 1.04171442093217 0.000272475544954865 -2.00320334289066 3.9598668244402e-09 miRanda -0.271769978727668 0.00186178178431082 NA NA NA hsa-miR-93-5p PRKACB 1.7515174434778 1.59386482413883e-08 -2.00320334289066 3.9598668244402e-09 miRNAWalker2_validate -0.293844505175028 0.000169582064126035 NA NA NA hsa-miR-96-5p PRKACB 1.14243043653372 0.00942969392739105 -2.00320334289066 3.9598668244402e-09 miRNATAP -0.170553493993393 0.00429769927359632 NA NA NA hsa-miR-183-5p PRKCA 1.65900927871187 0.000522025364980187 -0.524945602243661 0.156845722980603 miRNATAP -0.31103089433757 3.16968192454963e-09 NA NA NA hsa-miR-193b-3p PRKCA 0.281752012268679 0.451258902263119 -0.524945602243661 0.156845722980603 miRNAWalker2_validate -0.484019253003446 4.65153076194767e-13 NA NA NA hsa-miR-193b-5p PRKCA 0.609581100028941 0.13923921336815 -0.524945602243661 0.156845722980603 mirMAP -0.433727503937308 7.91160654871288e-13 NA NA NA hsa-miR-200c-3p PRKCA 1.28185685499076 0.00369777635539177 -0.524945602243661 0.156845722980603 miRNATAP -0.158267946470227 0.0075664310799573 NA NA NA hsa-miR-214-3p PRKCA 1.01201534142544 0.00625092909225755 -0.524945602243661 0.156845722980603 mirMAP -0.229516662046359 0.00116026469450838 NA NA NA hsa-miR-218-5p PRKCA -0.987730614742492 0.0108295837207062 -0.524945602243661 0.156845722980603 mirMAP -0.340197633280215 2.69227593052796e-07 NA NA NA hsa-miR-22-5p PRKCA 0.804348748654247 0.000804065112767412 -0.524945602243661 0.156845722980603 mirMAP -0.289814182834915 0.0085643888637562 NA NA NA hsa-miR-224-5p PRKCA 2.7648036144402 0.000111736336240167 -0.524945602243661 0.156845722980603 mirMAP -0.266077095767105 2.93934461700145e-15 NA NA NA hsa-miR-2355-3p PRKCA 0.982963823342009 0.0229275810851348 -0.524945602243661 0.156845722980603 mirMAP -0.192620283882863 0.00177074877059007 NA NA NA hsa-miR-24-2-5p PRKCA 1.24948624677556 6.95051249640114e-07 -0.524945602243661 0.156845722980603 miRNAWalker2_validate -0.44305928315788 1.26846671995315e-05 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-3065-5p PRKCA -0.241623656423063 0.633116553078159 -0.524945602243661 0.156845722980603 mirMAP -0.138739209322651 0.00952332540419745 NA NA NA hsa-miR-30e-3p PRKCA -0.913131357083321 7.29096855615228e-06 -0.524945602243661 0.156845722980603 mirMAP -0.480631092157774 0.000179519199509064 NA NA NA hsa-miR-340-5p PRKCA -0.164941927483643 0.529910509321278 -0.524945602243661 0.156845722980603 mirMAP -0.30203863377261 0.00294907401860914 NA NA NA hsa-miR-369-3p PRKCA 0.32261175629684 0.3589927609891 -0.524945602243661 0.156845722980603 PITA;miRNATAP -0.329749662436249 8.7729830203155e-06 NA NA NA hsa-miR-374a-3p PRKCA 0.0420912023953779 0.851478041312794 -0.524945602243661 0.156845722980603 mirMAP -0.476867699823759 5.6043349916606e-05 NA NA NA hsa-miR-374a-5p PRKCA -0.116485410477589 0.554703396010082 -0.524945602243661 0.156845722980603 mirMAP -0.356017213117889 0.00964742858084568 NA NA NA hsa-miR-381-3p PRKCA -0.385137659444633 0.19550293487428 -0.524945602243661 0.156845722980603 mirMAP -0.251195477739459 0.00489691969707007 NA NA NA hsa-miR-452-5p PRKCA 2.08756506185889 0.000258095769002813 -0.524945602243661 0.156845722980603 mirMAP -0.362021740586027 3.81652270570704e-18 NA NA NA hsa-miR-485-3p PRKCA 0.402652239390796 0.291980476362068 -0.524945602243661 0.156845722980603 PITA -0.187072641608852 0.00755799449285324 NA NA NA hsa-miR-590-3p PRKCA 1.11654983899947 0.000160782154924864 -0.524945602243661 0.156845722980603 PITA;miRanda;mirMAP;miRNATAP -0.253263144251919 0.0041311394662334 NA NA NA hsa-miR-654-3p PRKCA -0.180620884059292 0.603937505298333 -0.524945602243661 0.156845722980603 mirMAP -0.244452048619274 0.00127970540235088 NA NA NA hsa-miR-9-3p PRKCA 0.330346058941473 0.541111939982661 -0.524945602243661 0.156845722980603 mirMAP -0.16554523182915 0.00109100333735947 NA NA NA hsa-miR-9-5p PRKCA -0.195328736653048 0.761470692992178 -0.524945602243661 0.156845722980603 miRNATAP -0.159066735795387 8.70395397790985e-05 NA NA NA hsa-miR-93-3p PRKCA 1.88964231421793 1.80075645722786e-08 -0.524945602243661 0.156845722980603 mirMAP -0.204378358847077 0.00717568024324572 NA NA NA hsa-miR-944 PRKCA 3.33123095809751 0.0177835044930391 -0.524945602243661 0.156845722980603 PITA;miRNATAP -0.18876945085729 3.75302733857894e-21 NA NA NA hsa-miR-141-5p PRKCB 2.07543489990205 6.42575039070838e-06 -1.4030462275744 0.00367216720425109 mirMAP -0.395737238483437 3.03734398729028e-08 NA NA NA hsa-miR-16-2-3p PRKCB 1.8048179609245 2.83095715136409e-09 -1.4030462275744 0.00367216720425109 mirMAP -0.394725287595774 0.000305348610545586 NA NA NA hsa-miR-200b-3p PRKCB 0.974577911407732 0.0595020056914543 -1.4030462275744 0.00367216720425109 MirTarget -0.282755939415459 1.75770095316849e-05 NA NA NA hsa-miR-200c-3p PRKCB 1.28185685499076 0.00369777635539177 -1.4030462275744 0.00367216720425109 MirTarget;miRNATAP -0.484133503530668 8.09834496190732e-11 NA NA NA hsa-miR-23a-3p PRKCB 1.10685926969665 3.16223452471768e-08 -1.4030462275744 0.00367216720425109 mirMAP -0.683926072101064 5.15520137880557e-05 NA NA NA hsa-miR-24-3p PRKCB 1.08578167539644 6.18549359075268e-07 -1.4030462275744 0.00367216720425109 miRNATAP -0.723177032098718 2.88589756557307e-06 NA NA NA hsa-miR-27a-3p PRKCB 1.29886998470345 2.68986118553486e-08 -1.4030462275744 0.00367216720425109 MirTarget;miRNATAP -0.51359480289477 0.000369553651535914 NA NA NA hsa-miR-335-3p PRKCB 2.5197689063267 2.20084506976733e-09 -1.4030462275744 0.00367216720425109 mirMAP -0.29799969660431 0.000138565873644795 NA NA NA hsa-miR-429 PRKCB 1.40182602301928 0.00900426780286475 -1.4030462275744 0.00367216720425109 MirTarget;miRanda;miRNATAP -0.304844311690637 1.18954411842667e-06 NA NA NA hsa-miR-452-3p PRKCB 2.2028815467959 0.00185370432491004 -1.4030462275744 0.00367216720425109 mirMAP -0.17651507962963 0.00117496673508882 NA NA NA hsa-miR-589-3p PRKCB 1.01962606923682 0.00577853347252709 -1.4030462275744 0.00367216720425109 mirMAP -0.261170452838673 0.00515336080055526 NA NA NA hsa-miR-589-5p PRKCB 0.702695092403762 0.00395772685954799 -1.4030462275744 0.00367216720425109 mirMAP -0.370279961813979 0.00967226035852969 NA NA NA hsa-miR-590-5p PRKCB 1.04171442093217 0.000272475544954865 -1.4030462275744 0.00367216720425109 miRanda -0.40560794652637 0.000708295993250929 NA NA NA hsa-miR-616-5p PRKCB 0.834052908652744 0.0347835664029363 -1.4030462275744 0.00367216720425109 mirMAP -0.374505698749983 2.12152566695212e-05 NA NA NA hsa-miR-9-3p PRKCB 0.330346058941473 0.541111939982661 -1.4030462275744 0.00367216720425109 mirMAP -0.172769921695024 0.00989297046602862 NA NA NA hsa-miR-2355-5p PRKCG 0.594869787574182 0.120591076715177 -0.106646796932468 0.91801459782895 MirTarget -0.976109502699328 1.98177589887047e-07 NA NA NA hsa-miR-29b-3p PRKX -0.230693226193598 0.367461626035234 0.935407411100726 0.00677599594067682 mirMAP -0.295729445077546 0.00247925909788979 NA NA NA hsa-miR-29c-3p PRKX -1.62454036584589 5.38376515586029e-07 0.935407411100726 0.00677599594067682 mirMAP -0.21153018883656 0.00447069863244723 NA NA NA hsa-miR-375 PRKX -2.94506033785642 0.00570147601654791 0.935407411100726 0.00677599594067682 miRNAWalker2_validate;miRanda -0.117495305006097 1.46576878210263e-07 NA NA NA hsa-let-7g-3p PTPN5 0.64979533805273 0.0103084600883006 -2.57164506793757 4.18069401233043e-05 MirTarget -0.844183739176065 1.98555668413273e-06 NA NA NA hsa-miR-128-3p PTPN5 0.98280381420517 5.77641850797209e-05 -2.57164506793757 4.18069401233043e-05 MirTarget -0.736366086505496 6.00475797587428e-05 NA NA NA hsa-miR-296-5p PTPN5 0.932146077883618 0.0602370559607489 -2.57164506793757 4.18069401233043e-05 miRNATAP -0.287858035187409 0.00251346551740468 NA NA NA hsa-miR-3922-3p PTPN5 1.33252322927569 0.000665307190249975 -2.57164506793757 4.18069401233043e-05 miRNATAP -0.507029201911618 0.000128626458321117 NA NA NA hsa-miR-429 PTPN5 1.40182602301928 0.00900426780286475 -2.57164506793757 4.18069401233043e-05 miRanda -0.255685315477601 0.00233572783536137 NA NA NA hsa-miR-616-5p PTPN5 0.834052908652744 0.0347835664029363 -2.57164506793757 4.18069401233043e-05 miRNATAP -0.394784295101448 0.000720515848772821 NA NA NA hsa-miR-744-3p PTPN5 1.40439584998788 0.000973603203532439 -2.57164506793757 4.18069401233043e-05 MirTarget -0.648345403452202 1.84669175404154e-10 NA NA NA hsa-miR-940 PTPN5 1.64406174271686 0.000690854900107004 -2.57164506793757 4.18069401233043e-05 miRNATAP -0.47580652727939 1.09324482686479e-05 NA NA NA hsa-miR-218-5p PTPRR -0.987730614742492 0.0108295837207062 -0.481215827061428 0.532475906412888 miRNATAP -0.588622364999729 2.272473423795e-05 NA NA NA hsa-miR-34c-5p PTPRR 2.20632574870337 0.000379662996168678 -0.481215827061428 0.532475906412888 miRanda -0.578055804274271 3.50830604527654e-12 NA NA NA hsa-miR-455-3p PTPRR 2.29532323519288 1.85675588946527e-07 -0.481215827061428 0.532475906412888 MirTarget;PITA;miRNATAP -0.467623872844425 8.93816920346458e-05 NA NA NA hsa-miR-30c-5p RAC1 -0.983130268805942 4.60419218706127e-05 0.63005132289186 0.00013432252267484 miRNAWalker2_validate -0.215519718166738 7.09586530438521e-06 NA NA NA hsa-miR-375 RAC2 -2.94506033785642 0.00570147601654791 1.62151327855796 1.05038880277147e-05 miRanda -0.111436700267932 4.91783218198251e-06 NA NA NA hsa-miR-342-3p RAC3 0.318119432680668 0.269150960124243 0.309748967802459 0.467555115343412 miRanda -0.296741961155951 0.00517182849282247 NA NA NA hsa-miR-146b-3p RAF1 1.10138643500522 3.66835580263893e-05 -0.8632101633735 1.53817801108877e-10 MirTarget;PITA;miRNATAP -0.120516156621644 0.00105150756879764 NA NA NA hsa-miR-484 RAF1 0.71327898984355 0.00233605130771196 -0.8632101633735 1.53817801108877e-10 MirTarget -0.121560277635947 0.00438132826235516 NA NA NA hsa-let-7b-3p RAP1A 0.21838629112113 0.296038413622566 -0.772501622846852 5.1689262273662e-06 mirMAP -0.217079459567573 0.000264442278966232 NA NA NA hsa-let-7f-1-3p RAP1A 1.28704406797397 1.17954701106157e-06 -0.772501622846852 5.1689262273662e-06 mirMAP -0.167069513819751 0.000211876689647579 NA NA NA hsa-miR-16-1-3p RAP1A 1.43227522002564 3.70920454953168e-08 -0.772501622846852 5.1689262273662e-06 MirTarget -0.134631650461086 0.0033164342397994 NA NA NA hsa-miR-16-2-3p RAP1A 1.8048179609245 2.83095715136409e-09 -0.772501622846852 5.1689262273662e-06 MirTarget;mirMAP -0.200240334476887 1.2724386289425e-07 NA NA NA hsa-miR-24-3p RAP1A 1.08578167539644 6.18549359075268e-07 -0.772501622846852 5.1689262273662e-06 MirTarget -0.166797591955946 0.00266552085157724 NA NA NA hsa-miR-25-3p RAP1A 1.00604871526544 0.000421838061147906 -0.772501622846852 5.1689262273662e-06 mirMAP -0.129283658956735 0.00242095975751324 NA NA NA hsa-miR-324-5p RAP1A 1.08820215809537 3.11674414561836e-05 -0.772501622846852 5.1689262273662e-06 miRanda -0.126768604988696 0.00638929526461107 NA NA NA hsa-miR-335-3p RAP1A 2.5197689063267 2.20084506976733e-09 -0.772501622846852 5.1689262273662e-06 mirMAP -0.140810699066517 2.26681625031595e-07 NA NA NA hsa-miR-3913-5p RAP1A 0.878857760706319 0.00310224428304055 -0.772501622846852 5.1689262273662e-06 mirMAP -0.190850329131178 2.6242221182578e-06 NA NA NA hsa-miR-550a-3p RAP1A 2.05849884025997 7.99642185793604e-07 -0.772501622846852 5.1689262273662e-06 miRNATAP -0.132977048127842 2.0082553605051e-05 NA NA NA hsa-miR-590-5p RAP1A 1.04171442093217 0.000272475544954865 -0.772501622846852 5.1689262273662e-06 miRanda -0.124133751597277 0.00348053373625042 NA NA NA hsa-miR-92a-3p RAP1A 1.2209325870225 6.8757197708107e-06 -0.772501622846852 5.1689262273662e-06 mirMAP;miRNATAP -0.249902757513225 6.45614852944572e-09 NA NA NA hsa-miR-92b-3p RAP1A 1.33518446513417 1.45350885391576e-06 -0.772501622846852 5.1689262273662e-06 mirMAP;miRNATAP -0.141196217895113 0.00109118916644374 NA NA NA hsa-miR-106b-5p RAPGEF2 1.70863907461894 2.04074794107142e-08 -0.748066211311126 0.00077524438326186 MirTarget;miRNATAP -0.143637042940873 0.00464692212660958 NA NA NA hsa-miR-127-5p RAPGEF2 0.684144175589776 0.021634535736883 -0.748066211311126 0.00077524438326186 MirTarget;PITA;miRNATAP -0.179985736266544 0.000761769512788151 NA NA NA hsa-miR-149-5p RAPGEF2 0.706277554734069 0.296848731347677 -0.748066211311126 0.00077524438326186 miRNAWalker2_validate -0.162193254444294 2.66427962638379e-13 NA NA NA hsa-miR-15b-5p RAPGEF2 1.62046407540723 5.42152621571078e-09 -0.748066211311126 0.00077524438326186 miRNATAP -0.196754583760512 0.000371581506750732 NA NA NA hsa-miR-16-5p RAPGEF2 1.00515772948091 5.33912942007619e-06 -0.748066211311126 0.00077524438326186 miRNATAP -0.200287596295706 0.00526437606472635 NA NA NA hsa-miR-23a-3p RAPGEF2 1.10685926969665 3.16223452471768e-08 -0.748066211311126 0.00077524438326186 miRNATAP -0.545323862561121 1.92909609463611e-13 NA NA NA hsa-miR-23b-3p RAPGEF2 -0.286465516491361 0.18664668472995 -0.748066211311126 0.00077524438326186 miRNATAP -0.302911700601615 4.39797979835357e-05 NA NA NA hsa-miR-24-3p RAPGEF2 1.08578167539644 6.18549359075268e-07 -0.748066211311126 0.00077524438326186 MirTarget;miRNATAP -0.564559869570231 3.22263231984513e-17 NA NA NA hsa-miR-27a-3p RAPGEF2 1.29886998470345 2.68986118553486e-08 -0.748066211311126 0.00077524438326186 MirTarget;miRNATAP -0.498959641883344 1.06722613634745e-15 NA NA NA hsa-miR-27b-3p RAPGEF2 0.0836323965901755 0.725273923274 -0.748066211311126 0.00077524438326186 MirTarget;miRNATAP -0.420911540377865 1.18394551827069e-10 NA NA NA hsa-miR-331-3p RAPGEF2 1.04880525429426 9.99995355989124e-05 -0.748066211311126 0.00077524438326186 MirTarget -0.227931773360194 8.99794875367228e-05 NA NA NA hsa-miR-369-3p RAPGEF2 0.32261175629684 0.3589927609891 -0.748066211311126 0.00077524438326186 MirTarget;PITA;miRNATAP -0.128536631872731 0.00479241031999842 NA NA NA hsa-miR-374b-3p RAPGEF2 0.999491658196932 0.00126937019814872 -0.748066211311126 0.00077524438326186 MirTarget -0.158448460260459 0.00351829498727553 NA NA NA hsa-miR-379-5p RAPGEF2 0.0928358360950554 0.768753888894121 -0.748066211311126 0.00077524438326186 miRNATAP -0.204127992310586 5.07124927134816e-05 NA NA NA hsa-miR-511-5p RAPGEF2 0.542335183701817 0.127507740178883 -0.748066211311126 0.00077524438326186 MirTarget -0.120991856015663 0.00715098125767547 NA NA NA hsa-miR-582-3p RAPGEF2 -0.412897415951272 0.202939245403793 -0.748066211311126 0.00077524438326186 PITA;miRNATAP -0.141716029178086 0.00415043776870828 NA NA NA hsa-miR-940 RAPGEF2 1.64406174271686 0.000690854900107004 -0.748066211311126 0.00077524438326186 MirTarget;PITA;miRNATAP -0.215932542014409 6.53468112758742e-09 NA NA NA hsa-miR-944 RAPGEF2 3.33123095809751 0.0177835044930391 -0.748066211311126 0.00077524438326186 MirTarget;PITA;miRNATAP -0.113902169849924 5.17036268942388e-21 NA NA NA hsa-miR-361-5p RASA1 0.407725414130987 0.0181260969156347 0.0522348686686147 0.756194566050682 miRanda -0.209203208349243 0.00302450346969509 NA NA NA hsa-let-7a-3p RASGRF2 0.503048155002889 0.0411145454335299 -0.110309077538892 0.784525220880563 mirMAP -0.472702906326776 4.69406106421052e-05 NA NA NA hsa-let-7b-3p RASGRF2 0.21838629112113 0.296038413622566 -0.110309077538892 0.784525220880563 mirMAP -0.404882396564303 0.00382189101035453 NA NA NA hsa-miR-106b-5p RASGRF2 1.70863907461894 2.04074794107142e-08 -0.110309077538892 0.784525220880563 MirTarget -0.270879412386259 0.00289856195344377 NA NA NA hsa-miR-17-5p RASGRF2 1.65862087862483 8.45603406215941e-08 -0.110309077538892 0.784525220880563 MirTarget;TargetScan -0.268490094318991 0.00277983925629893 NA NA NA hsa-miR-182-5p RASGRF2 0.887369486030646 0.0310640781418789 -0.110309077538892 0.784525220880563 mirMAP -0.348530339774225 2.66556386326429e-07 NA NA NA hsa-miR-20a-5p RASGRF2 1.4503375861709 5.7813456424762e-07 -0.110309077538892 0.784525220880563 MirTarget -0.255067154431753 0.00830339669437364 NA NA NA hsa-miR-224-5p RASGRF2 2.7648036144402 0.000111736336240167 -0.110309077538892 0.784525220880563 MirTarget -0.151144416874801 9.92307863285326e-05 NA NA NA hsa-miR-3065-5p RASGRF2 -0.241623656423063 0.633116553078159 -0.110309077538892 0.784525220880563 mirMAP -0.194815043185266 0.000742491857024403 NA NA NA hsa-miR-324-5p RASGRF2 1.08820215809537 3.11674414561836e-05 -0.110309077538892 0.784525220880563 miRNATAP -0.329249943424611 0.00238610953565126 NA NA NA hsa-miR-590-5p RASGRF2 1.04171442093217 0.000272475544954865 -0.110309077538892 0.784525220880563 miRanda -0.344571007524197 0.000490057355380908 NA NA NA hsa-miR-324-3p RASGRP2 1.04940352369965 0.000387716796520961 -1.81023681128664 0.00024193779088964 PITA -0.61614188158445 1.27289198442174e-07 NA NA NA hsa-miR-484 RASGRP2 0.71327898984355 0.00233605130771196 -1.81023681128664 0.00024193779088964 PITA -0.615721134776884 4.65040498472232e-05 NA NA NA hsa-miR-940 RASGRP2 1.64406174271686 0.000690854900107004 -1.81023681128664 0.00024193779088964 MirTarget;PITA;miRNATAP -0.484691818914087 5.3351959566511e-09 NA NA NA hsa-miR-324-3p RASGRP3 1.04940352369965 0.000387716796520961 -0.0864115642863696 0.815827574333325 MirTarget -0.462187758782577 7.85805142563284e-08 NA NA NA hsa-miR-34c-5p RASGRP3 2.20632574870337 0.000379662996168678 -0.0864115642863696 0.815827574333325 miRanda -0.204699381447158 6.39509119948026e-07 NA NA NA hsa-miR-365a-3p RASGRP3 -0.891537000455889 0.0025537650440002 -0.0864115642863696 0.815827574333325 MirTarget -0.471191895625401 4.97718056766004e-08 NA NA NA hsa-miR-944 RASGRP3 3.33123095809751 0.0177835044930391 -0.0864115642863696 0.815827574333325 mirMAP -0.186294617320451 1.33302684859812e-20 NA NA NA hsa-miR-30b-3p RASGRP4 -0.266398938200332 0.400847813143994 -0.503046296554765 0.202621870436041 MirTarget -0.242394213658848 0.00657964905583331 NA NA NA hsa-miR-577 RASGRP4 0.911619788986754 0.2256062124148 -0.503046296554765 0.202621870436041 miRNATAP -0.157500037587732 2.85843806310828e-05 NA NA NA hsa-miR-616-5p RASGRP4 0.834052908652744 0.0347835664029363 -0.503046296554765 0.202621870436041 MirTarget -0.269569241003242 0.000169961330303463 NA NA NA hsa-miR-101-5p RELA -0.567139223563276 0.0306291767849722 0.140295374000207 0.30305268869391 mirMAP -0.114893897809984 0.00171325410868005 NA NA NA hsa-miR-30e-5p RELA -0.573784818166736 0.0112497802572927 0.140295374000207 0.30305268869391 miRNAWalker2_validate -0.152968732905743 0.000301446483160409 NA NA NA hsa-miR-125b-5p RPS6KA1 -0.509303501421334 0.133265526313161 0.731929498307813 0.00274490008057769 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.234526493366172 3.98094595496741e-06 NA NA NA hsa-miR-1271-5p RPS6KA2 1.15538250415776 0.00207865862606828 -1.32620092187925 2.65708033500017e-05 mirMAP -0.250754934912831 3.52487370999946e-05 NA NA NA hsa-miR-17-5p RPS6KA2 1.65862087862483 8.45603406215941e-08 -1.32620092187925 2.65708033500017e-05 TargetScan -0.277422161233165 9.72880459807237e-05 NA NA NA hsa-miR-185-3p RPS6KA2 1.33711019171256 3.45756583967985e-05 -1.32620092187925 2.65708033500017e-05 MirTarget -0.240253769790685 0.000545054552010221 NA NA NA hsa-miR-193a-3p RPS6KA2 0.214911823818578 0.399323056245552 -1.32620092187925 2.65708033500017e-05 mirMAP -0.26491153991581 0.00356573319385792 NA NA NA hsa-miR-193b-3p RPS6KA2 0.281752012268679 0.451258902263119 -1.32620092187925 2.65708033500017e-05 mirMAP -0.384306076520259 6.13728537538736e-11 NA NA NA hsa-miR-200c-3p RPS6KA2 1.28185685499076 0.00369777635539177 -1.32620092187925 2.65708033500017e-05 miRNATAP -0.150094253971244 0.00345925344024124 NA NA NA hsa-miR-3065-5p RPS6KA2 -0.241623656423063 0.633116553078159 -1.32620092187925 2.65708033500017e-05 mirMAP -0.150030422411658 0.00116928469807079 NA NA NA hsa-miR-9-3p RPS6KA2 0.330346058941473 0.541111939982661 -1.32620092187925 2.65708033500017e-05 MirTarget -0.154999756788344 0.000413323743564195 NA NA NA hsa-miR-9-5p RPS6KA2 -0.195328736653048 0.761470692992178 -1.32620092187925 2.65708033500017e-05 miRNATAP -0.141211407273439 5.87920360984724e-05 NA NA NA hsa-miR-93-3p RPS6KA2 1.88964231421793 1.80075645722786e-08 -1.32620092187925 2.65708033500017e-05 MirTarget -0.214747999929332 0.00107758815639912 NA NA NA hsa-let-7b-5p RPS6KA3 0.0582902155815681 0.781400138984745 0.346210158747265 0.0773954948531251 miRNATAP -0.285029367054611 1.95742569529439e-05 NA NA NA hsa-miR-218-5p RPS6KA3 -0.987730614742492 0.0108295837207062 0.346210158747265 0.0773954948531251 miRNATAP -0.179036217251255 2.72800797735199e-07 25943352 We found that decreased miR-218 expression in GBM cells also increased the expression of genes encoding additional upstream and downstream components of RTK signaling pathways including the RTK platelet-derived growth factor receptor α PDGFRα and the kinases ribosomal S6 kinase 2 RSK2 and S6 kinase 1 S6K1 that collectively overrode the negative feedback mechanism glioblastoma hsa-miR-23a-3p RPS6KA3 1.10685926969665 3.16223452471768e-08 0.346210158747265 0.0773954948531251 mirMAP -0.275185887578108 4.74570150183976e-05 NA NA NA hsa-miR-23b-3p RPS6KA3 -0.286465516491361 0.18664668472995 0.346210158747265 0.0773954948531251 mirMAP -0.21401921753921 0.000992707720998224 NA NA NA hsa-miR-452-5p RPS6KA3 2.08756506185889 0.000258095769002813 0.346210158747265 0.0773954948531251 MirTarget;miRNATAP -0.115013851222988 8.80272333036024e-07 NA NA NA hsa-miR-363-3p RPS6KA4 -1.16644295837328 0.0156502158960458 0.746042076745049 0.00139692932248809 MirTarget -0.148852998811884 1.15606917276826e-05 NA NA NA hsa-miR-423-5p RPS6KA4 0.832613878736338 0.000791321227103338 0.746042076745049 0.00139692932248809 MirTarget -0.196832561196649 0.00349945917280641 NA NA NA hsa-miR-106b-5p RPS6KA5 1.70863907461894 2.04074794107142e-08 -1.15315742112682 3.77444581535993e-05 MirTarget -0.313990966001478 6.34442165336619e-07 NA NA NA hsa-miR-107 RPS6KA5 0.904627575346218 4.67936495073904e-05 -1.15315742112682 3.77444581535993e-05 miRanda -0.386885099458665 1.63625900776216e-05 NA NA NA hsa-miR-128-3p RPS6KA5 0.98280381420517 5.77641850797209e-05 -1.15315742112682 3.77444581535993e-05 miRNAWalker2_validate;MirTarget -0.263247889713887 0.00136452810685446 NA NA NA hsa-miR-1292-5p RPS6KA5 0.785867247880547 0.0637440977048249 -1.15315742112682 3.77444581535993e-05 MirTarget -0.237296484411299 0.000131737401562042 NA NA NA hsa-miR-130b-3p RPS6KA5 1.32714007211004 4.78676252285191e-05 -1.15315742112682 3.77444581535993e-05 MirTarget -0.255640362702205 2.31198274172861e-05 NA NA NA hsa-miR-142-5p RPS6KA5 1.55592486377018 6.69269968016779e-06 -1.15315742112682 3.77444581535993e-05 MirTarget;PITA;mirMAP;miRNATAP -0.231245100465352 4.71089684797338e-05 NA NA NA hsa-miR-148b-3p RPS6KA5 0.295175884456199 0.17466422420702 -1.15315742112682 3.77444581535993e-05 MirTarget -0.396315702334231 2.34883395836523e-05 NA NA NA hsa-miR-17-5p RPS6KA5 1.65862087862483 8.45603406215941e-08 -1.15315742112682 3.77444581535993e-05 MirTarget;TargetScan -0.203685263528354 0.00131293240401629 NA NA NA hsa-miR-18a-5p RPS6KA5 2.20211504140984 1.78678887916334e-09 -1.15315742112682 3.77444581535993e-05 MirTarget -0.237241569001284 5.61065517327682e-06 NA NA NA hsa-miR-19a-3p RPS6KA5 1.26669687448473 0.000105972838514412 -1.15315742112682 3.77444581535993e-05 miRNAWalker2_validate;MirTarget -0.201536903999906 0.000952782774994876 NA NA NA hsa-miR-19b-3p RPS6KA5 0.759818275708988 0.00652779573186786 -1.15315742112682 3.77444581535993e-05 MirTarget -0.19672184531091 0.00679675776715461 NA NA NA hsa-miR-20a-3p RPS6KA5 1.13957127410163 0.000451087640268489 -1.15315742112682 3.77444581535993e-05 miRNATAP -0.207281089246108 0.000757638230134798 NA NA NA hsa-miR-20a-5p RPS6KA5 1.4503375861709 5.7813456424762e-07 -1.15315742112682 3.77444581535993e-05 MirTarget -0.195631108297925 0.00415499953842349 NA NA NA hsa-miR-330-3p RPS6KA5 0.798460296022179 0.00746538156533435 -1.15315742112682 3.77444581535993e-05 MirTarget -0.234811988091265 0.000504292508766168 NA NA NA hsa-miR-335-3p RPS6KA5 2.5197689063267 2.20084506976733e-09 -1.15315742112682 3.77444581535993e-05 mirMAP -0.197371124918625 1.40195954965813e-05 NA NA NA hsa-miR-590-3p RPS6KA5 1.11654983899947 0.000160782154924864 -1.15315742112682 3.77444581535993e-05 miRanda -0.308810483167574 3.64510028186383e-06 NA NA NA hsa-miR-7-1-3p RPS6KA5 0.709309110750947 0.0412301737463194 -1.15315742112682 3.77444581535993e-05 mirMAP -0.197381553121598 0.000671759637898012 NA NA NA hsa-miR-942-5p RPS6KA5 1.90585138008274 3.11903311044863e-09 -1.15315742112682 3.77444581535993e-05 MirTarget -0.246662879955566 3.89973558501937e-05 NA NA NA hsa-miR-141-3p RPS6KA6 1.45548825076434 0.00115958850961764 -5.00656872637833 4.11367694853314e-08 MirTarget -0.432468412213307 0.00360066422363021 NA NA NA hsa-miR-15a-5p RPS6KA6 1.03783090449383 7.40334108980898e-07 -5.00656872637833 4.11367694853314e-08 MirTarget -1.16712662892975 0.00022335981484185 NA NA NA hsa-miR-15b-5p RPS6KA6 1.62046407540723 5.42152621571078e-09 -5.00656872637833 4.11367694853314e-08 MirTarget -0.98737211999724 2.04686725019938e-05 NA NA NA hsa-miR-16-5p RPS6KA6 1.00515772948091 5.33912942007619e-06 -5.00656872637833 4.11367694853314e-08 MirTarget -1.17701610928795 8.80963847530128e-05 NA NA NA hsa-miR-17-5p RPS6KA6 1.65862087862483 8.45603406215941e-08 -5.00656872637833 4.11367694853314e-08 TargetScan -0.713815384598966 0.000699085878061688 NA NA NA hsa-miR-192-3p RPS6KA6 0.355565421687399 0.74117031340037 -5.00656872637833 4.11367694853314e-08 MirTarget -0.232226536686706 0.000226000863637598 NA NA NA hsa-miR-19a-3p RPS6KA6 1.26669687448473 0.000105972838514412 -5.00656872637833 4.11367694853314e-08 MirTarget -0.567774439590388 0.00532420547949485 NA NA NA hsa-miR-200a-3p RPS6KA6 0.717826667295984 0.193912116506827 -5.00656872637833 4.11367694853314e-08 MirTarget -0.3689692935826 0.0023827310098926 NA NA NA hsa-miR-335-3p RPS6KA6 2.5197689063267 2.20084506976733e-09 -5.00656872637833 4.11367694853314e-08 MirTarget -0.564882086576197 0.000205160896527142 NA NA NA hsa-miR-3662 RPS6KA6 1.82780708047676 0.0054036501346178 -5.00656872637833 4.11367694853314e-08 MirTarget -0.346660780011316 0.00849258086056814 NA NA NA hsa-miR-532-5p RPS6KA6 0.313080805824184 0.252248939356301 -5.00656872637833 4.11367694853314e-08 MirTarget;PITA;miRNATAP -0.858116720632928 0.00052951971496949 NA NA NA hsa-miR-1306-3p RRAS 0.330765927739412 0.365190645009445 -0.183682512102821 0.459473778131959 MirTarget -0.163033978538963 0.00195980072819489 NA NA NA hsa-miR-140-3p RRAS2 -0.296251775392129 0.127539826012144 0.0873449649116278 0.798145291977902 MirTarget;PITA;miRNATAP -0.514008282683254 4.71090508973884e-05 NA NA NA hsa-miR-194-5p RRAS2 -0.127742909829168 0.906065815804667 0.0873449649116278 0.798145291977902 MirTarget -0.151162480440524 8.10066422714336e-13 NA NA NA hsa-miR-29a-3p RRAS2 -0.113012156986374 0.615005009685815 0.0873449649116278 0.798145291977902 miRNATAP -0.341167254052947 0.00186147270079613 NA NA NA hsa-miR-29b-3p RRAS2 -0.230693226193598 0.367461626035234 0.0873449649116278 0.798145291977902 miRNATAP -0.300702022169431 0.00166288771949774 NA NA NA hsa-miR-29c-3p RRAS2 -1.62454036584589 5.38376515586029e-07 0.0873449649116278 0.798145291977902 miRNATAP -0.231042616010446 0.00147813263877111 NA NA NA hsa-miR-30a-5p RRAS2 -1.71922855140016 3.20574349285256e-07 0.0873449649116278 0.798145291977902 miRNATAP -0.197676570068884 0.00479286525967713 NA NA NA hsa-miR-30d-5p RRAS2 -0.5492586056147 0.0140125082460125 0.0873449649116278 0.798145291977902 miRNATAP -0.352053143425455 0.0012774863816614 NA NA NA hsa-miR-429 RRAS2 1.40182602301928 0.00900426780286475 0.0873449649116278 0.798145291977902 PITA;miRanda -0.120932450936441 0.00691410403298922 NA NA NA hsa-miR-7-5p RRAS2 1.63575693499363 0.0124424214624534 0.0873449649116278 0.798145291977902 miRNAWalker2_validate;MirTarget;miRNATAP -0.148893985928987 9.31253229982355e-05 NA NA NA hsa-miR-107 SOS1 0.904627575346218 4.67936495073904e-05 -0.312504597403338 0.0217354056927372 miRNATAP -0.145548441179847 0.000689923594720433 NA NA NA hsa-miR-212-3p SOS1 0.960352937108106 0.00133449812322732 -0.312504597403338 0.0217354056927372 miRNATAP -0.10285303580697 0.00125914157136999 NA NA NA hsa-miR-130b-3p SOS2 1.32714007211004 4.78676252285191e-05 -0.552553272187832 0.000842904756234712 miRNATAP -0.189945286925012 4.30620481406807e-08 NA NA NA hsa-miR-140-5p SOS2 0.208193069681326 0.303002433893804 -0.552553272187832 0.000842904756234712 miRanda -0.242708772607705 4.09198894582034e-05 NA NA NA hsa-miR-15a-5p SOS2 1.03783090449383 7.40334108980898e-07 -0.552553272187832 0.000842904756234712 miRNATAP -0.146415389758913 0.00881073243847914 NA NA NA hsa-miR-15b-5p SOS2 1.62046407540723 5.42152621571078e-09 -0.552553272187832 0.000842904756234712 miRNATAP -0.20706350866124 2.57218450390641e-07 NA NA NA hsa-miR-16-5p SOS2 1.00515772948091 5.33912942007619e-06 -0.552553272187832 0.000842904756234712 miRNATAP -0.262605428938621 4.24308774338413e-07 NA NA NA hsa-miR-320a SOS2 0.593888711838028 0.011897419390526 -0.552553272187832 0.000842904756234712 miRanda;miRNATAP -0.171180096354768 0.000654323522825758 NA NA NA hsa-miR-320b SOS2 1.11183660885284 0.000497971211648503 -0.552553272187832 0.000842904756234712 miRanda;miRNATAP -0.1894426744384 1.1640268989058e-07 NA NA NA hsa-miR-320c SOS2 0.455072851945474 0.240613785444485 -0.552553272187832 0.000842904756234712 miRanda;miRNATAP -0.140084445378509 6.27193555893877e-05 NA NA NA hsa-miR-330-3p SOS2 0.798460296022179 0.00746538156533435 -0.552553272187832 0.000842904756234712 PITA;miRNATAP -0.138104773165596 0.000447681879316435 NA NA NA hsa-miR-335-5p SOS2 1.59953351087307 5.56170899867314e-05 -0.552553272187832 0.000842904756234712 miRNAWalker2_validate -0.169702199646938 1.79676990124387e-09 NA NA NA hsa-miR-421 SOS2 1.80720854070385 1.59709651202848e-07 -0.552553272187832 0.000842904756234712 miRanda -0.144587437231913 1.02531118763523e-05 NA NA NA hsa-miR-424-5p SOS2 1.08509868581983 0.000420473853818268 -0.552553272187832 0.000842904756234712 miRNATAP -0.140604926460313 0.000199731330671148 NA NA NA hsa-miR-543 SOS2 0.0323775903217254 0.929458442755522 -0.552553272187832 0.000842904756234712 miRanda -0.111995751787288 0.00169071143522402 NA NA NA hsa-miR-590-3p SOS2 1.11654983899947 0.000160782154924864 -0.552553272187832 0.000842904756234712 miRanda;mirMAP -0.153192018213884 9.25459377799179e-05 NA NA NA hsa-miR-590-5p SOS2 1.04171442093217 0.000272475544954865 -0.552553272187832 0.000842904756234712 PITA;miRanda;miRNATAP -0.180915954835414 7.34917806636463e-06 NA NA NA hsa-miR-146b-5p SRF 1.547491371264 6.06614361290688e-08 -0.114184779759649 0.558880420285743 PITA -0.175098822900259 0.000170737999249024 NA NA NA hsa-miR-148a-3p SRF -1.53721533763578 3.55533747293117e-05 -0.114184779759649 0.558880420285743 mirMAP -0.115280877253787 0.00151193313482149 NA NA NA hsa-miR-342-3p SRF 0.318119432680668 0.269150960124243 -0.114184779759649 0.558880420285743 PITA;miRanda -0.143957229022703 0.00284386173858362 NA NA NA hsa-miR-140-5p STK3 0.208193069681326 0.303002433893804 0.793333426435852 4.46637740570453e-05 PITA;miRanda -0.322602028873078 3.76711251888266e-06 NA NA NA hsa-miR-29b-2-5p STK3 -1.7015307882027 2.84239251703401e-10 0.793333426435852 4.46637740570453e-05 MirTarget -0.22121858449854 6.79621678083929e-06 NA NA NA hsa-miR-338-5p STK3 -1.19659203838734 0.0100316010080496 0.793333426435852 4.46637740570453e-05 PITA -0.149572483616068 3.11680052053363e-07 NA NA NA hsa-miR-362-3p STK3 -0.0349414695893027 0.913780708043777 0.793333426435852 4.46637740570453e-05 miRanda -0.117392435557393 0.00747078148579124 NA NA NA hsa-miR-224-3p STK4 1.52422171450716 0.00650463542340912 0.548178366011 0.00108978985662648 MirTarget -0.105835326254386 3.48605814034794e-06 NA NA NA hsa-miR-23a-3p STK4 1.10685926969665 3.16223452471768e-08 0.548178366011 0.00108978985662648 MirTarget;miRNATAP -0.226204595257245 0.000108440594494015 NA NA NA hsa-miR-23b-3p STK4 -0.286465516491361 0.18664668472995 0.548178366011 0.00108978985662648 MirTarget;miRNATAP -0.344576266131766 1.68450726412007e-10 NA NA NA hsa-miR-139-5p STMN1 -1.83374360776637 1.22019901002824e-09 2.13001256303451 1.48294246055028e-13 miRanda -0.344680682207087 4.39832569140962e-07 NA NA NA hsa-miR-30a-5p STMN1 -1.71922855140016 3.20574349285256e-07 2.13001256303451 1.48294246055028e-13 miRNAWalker2_validate -0.21898604072909 0.000506248771639038 NA NA NA hsa-miR-338-3p STMN1 -0.959276231066179 0.0191473351014091 2.13001256303451 1.48294246055028e-13 miRanda -0.276376403668403 9.74326816365229e-08 NA NA NA hsa-let-7d-5p TAOK1 0.981733854788227 7.26366577706469e-07 -0.014457104454805 0.952044525012314 miRNATAP -0.278066953319723 0.0010680347087078 NA NA NA hsa-miR-106b-5p TAOK1 1.70863907461894 2.04074794107142e-08 -0.014457104454805 0.952044525012314 miRNATAP -0.170712985908362 0.00154776407528118 NA NA NA hsa-miR-130b-3p TAOK1 1.32714007211004 4.78676252285191e-05 -0.014457104454805 0.952044525012314 mirMAP -0.135890651512314 0.00821690010414104 NA NA NA hsa-miR-16-5p TAOK1 1.00515772948091 5.33912942007619e-06 -0.014457104454805 0.952044525012314 MirTarget;miRNATAP -0.201831878736015 0.00838215992606319 NA NA NA hsa-miR-197-3p TAOK1 0.888854270009261 0.000195183808214449 -0.014457104454805 0.952044525012314 MirTarget;miRNATAP -0.205712014896519 0.00382478459612364 NA NA NA hsa-miR-212-3p TAOK1 0.960352937108106 0.00133449812322732 -0.014457104454805 0.952044525012314 mirMAP -0.205696171311775 0.000260325936420285 NA NA NA hsa-miR-24-3p TAOK1 1.08578167539644 6.18549359075268e-07 -0.014457104454805 0.952044525012314 MirTarget;miRNATAP -0.262469766615371 0.000632217619814638 NA NA NA hsa-miR-26a-5p TAOK1 -0.384110714440647 0.0442498636014044 -0.014457104454805 0.952044525012314 mirMAP;miRNATAP -0.26736413695127 0.00333690473846636 NA NA NA hsa-miR-26b-5p TAOK1 -0.301646326928219 0.160081421968103 -0.014457104454805 0.952044525012314 mirMAP;miRNATAP -0.310517793568133 0.000103649138758597 NA NA NA hsa-miR-320b TAOK1 1.11183660885284 0.000497971211648503 -0.014457104454805 0.952044525012314 mirMAP;miRNATAP -0.215813660635719 3.55516924660943e-05 NA NA NA hsa-miR-33a-5p TAOK1 0.407757858040717 0.321429014317207 -0.014457104454805 0.952044525012314 mirMAP -0.134012364272012 0.0011657332745954 NA NA NA hsa-miR-340-5p TAOK1 -0.164941927483643 0.529910509321278 -0.014457104454805 0.952044525012314 mirMAP -0.234258850784075 0.000323852014193173 NA NA NA hsa-miR-374b-5p TAOK1 -0.188120735251554 0.394800117237392 -0.014457104454805 0.952044525012314 mirMAP;miRNATAP -0.202346561076679 0.00999903689937189 NA NA NA hsa-miR-424-5p TAOK1 1.08509868581983 0.000420473853818268 -0.014457104454805 0.952044525012314 MirTarget -0.204156057491213 0.000175322007072704 NA NA NA hsa-miR-542-3p TAOK1 0.757649022262991 0.00210575463285599 -0.014457104454805 0.952044525012314 miRanda -0.220877653893436 0.00137283498453779 NA NA NA hsa-miR-590-3p TAOK1 1.11654983899947 0.000160782154924864 -0.014457104454805 0.952044525012314 miRanda;mirMAP -0.164307394908655 0.00389669708326764 NA NA NA hsa-miR-940 TAOK1 1.64406174271686 0.000690854900107004 -0.014457104454805 0.952044525012314 miRNATAP -0.145753426489251 0.000344046626239036 NA NA NA hsa-miR-193b-3p TAOK2 0.281752012268679 0.451258902263119 -0.248981391698292 0.05970461673709 miRNATAP -0.122007635713381 5.5230537094127e-07 NA NA NA hsa-miR-106a-5p TAOK3 -0.173255688252641 0.642872703263671 -0.18219878676202 0.363688212752337 MirTarget -0.112100080104715 0.0032090936629981 NA NA NA hsa-miR-193b-3p TAOK3 0.281752012268679 0.451258902263119 -0.18219878676202 0.363688212752337 miRNAWalker2_validate -0.168715703323606 6.52588608625194e-06 NA NA NA hsa-miR-20b-5p TAOK3 -0.750137369661989 0.137699447213685 -0.18219878676202 0.363688212752337 MirTarget -0.103305781056644 0.000206652047794523 NA NA NA hsa-miR-218-5p TAOK3 -0.987730614742492 0.0108295837207062 -0.18219878676202 0.363688212752337 miRNATAP -0.205163405627759 5.58019020883909e-09 NA NA NA hsa-miR-296-5p TAOK3 0.932146077883618 0.0602370559607489 -0.18219878676202 0.363688212752337 MirTarget;PITA;miRNATAP -0.159004317691712 3.50169911979634e-08 NA NA NA hsa-miR-361-5p TAOK3 0.407725414130987 0.0181260969156347 -0.18219878676202 0.363688212752337 miRanda -0.274366090479663 0.00113036397385475 NA NA NA hsa-miR-493-5p TAOK3 0.962900723235399 0.00324541076496571 -0.18219878676202 0.363688212752337 MirTarget;miRNATAP -0.126705221074901 0.00327857822070058 NA NA NA hsa-miR-494-3p TAOK3 0.629125800836413 0.111160489070425 -0.18219878676202 0.363688212752337 MirTarget -0.10351043563952 0.00443005032781148 NA NA NA hsa-miR-93-5p TAOK3 1.7515174434778 1.59386482413883e-08 -0.18219878676202 0.363688212752337 MirTarget -0.115544500611778 0.00912327925055519 NA NA NA hsa-miR-139-5p TGFB1 -1.83374360776637 1.22019901002824e-09 0.921978024389205 0.015443067273438 miRanda -0.231228229661 0.00779949032347728 NA NA NA hsa-miR-29b-3p TGFB1 -0.230693226193598 0.367461626035234 0.921978024389205 0.015443067273438 miRTarBase -0.456958304413375 1.70622144738106e-05 NA NA NA hsa-miR-141-3p TGFB2 1.45548825076434 0.00115958850961764 0.531711555933475 0.237271821958403 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.310711996035385 7.80220336778334e-06 NA NA NA hsa-miR-148a-3p TGFB2 -1.53721533763578 3.55533747293117e-05 0.531711555933475 0.237271821958403 MirTarget;miRNATAP -0.220405364068209 0.00926503682050518 NA NA NA hsa-miR-148b-3p TGFB2 0.295175884456199 0.17466422420702 0.531711555933475 0.237271821958403 MirTarget -0.467759048012148 0.00176540723814519 NA NA NA hsa-miR-200a-3p TGFB2 0.717826667295984 0.193912116506827 0.531711555933475 0.237271821958403 MirTarget;miRNATAP -0.252010151933484 9.49127408816544e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 1.44736908507496 0.0394116388736904 0.531711555933475 0.237271821958403 MirTarget -0.165925482602356 0.000218164630138837 NA NA NA hsa-miR-32-3p TGFB2 0.583525764322974 0.11837203008551 0.531711555933475 0.237271821958403 mirMAP -0.25717146688254 0.00779413036125543 NA NA NA hsa-miR-330-3p TGFB2 0.798460296022179 0.00746538156533435 0.531711555933475 0.237271821958403 miRNATAP -0.296195247581737 0.00574751539933769 NA NA NA hsa-miR-33a-3p TGFB2 0.347011402017138 0.321709379745392 0.531711555933475 0.237271821958403 MirTarget;mirMAP -0.39918681868845 2.86864367014074e-05 NA NA NA hsa-miR-375 TGFB2 -2.94506033785642 0.00570147601654791 0.531711555933475 0.237271821958403 miRNAWalker2_validate -0.135378292973885 3.38653961690956e-06 NA NA NA hsa-miR-429 TGFB2 1.40182602301928 0.00900426780286475 0.531711555933475 0.237271821958403 miRNATAP -0.282945695650806 1.02668418456713e-06 NA NA NA hsa-let-7f-1-3p TGFB3 1.28704406797397 1.17954701106157e-06 -1.10894161909252 0.00498726268551547 MirTarget -0.272732273807511 0.00950753209568666 NA NA NA hsa-miR-10a-5p TGFB3 -0.470861534765518 0.148803248989189 -1.10894161909252 0.00498726268551547 miRNAWalker2_validate -0.277127145258827 0.00143360908543031 NA NA NA hsa-miR-151a-5p TGFB3 1.24363461949586 2.18236940049108e-07 -1.10894161909252 0.00498726268551547 MirTarget -0.661467214905873 3.42539039149492e-09 NA NA NA hsa-miR-26b-3p TGFB3 -0.0103961389461977 0.965770899625511 -1.10894161909252 0.00498726268551547 MirTarget -0.511617229426091 1.24500682090535e-05 NA NA NA hsa-miR-29a-3p TGFB3 -0.113012156986374 0.615005009685815 -1.10894161909252 0.00498726268551547 miRNAWalker2_validate -0.395874477357522 0.00201300163223496 NA NA NA hsa-miR-29b-3p TGFB3 -0.230693226193598 0.367461626035234 -1.10894161909252 0.00498726268551547 miRTarBase -0.379512133029508 0.000666754329763779 NA NA NA hsa-miR-338-5p TGFB3 -1.19659203838734 0.0100316010080496 -1.10894161909252 0.00498726268551547 PITA -0.236666190238514 7.75982569882353e-05 NA NA NA hsa-miR-590-3p TGFB3 1.11654983899947 0.000160782154924864 -1.10894161909252 0.00498726268551547 miRanda -0.312543185476898 0.000937918421040375 NA NA NA hsa-miR-629-3p TGFB3 1.40326397107309 9.7803063526732e-05 -1.10894161909252 0.00498726268551547 MirTarget -0.252264250229092 0.00108443910675355 NA NA NA hsa-miR-101-3p TGFBR1 -0.451263906815861 0.0283387250173031 -0.251712186913126 0.256800460803047 miRNAWalker2_validate;miRNATAP -0.334479809747145 1.26739295835297e-05 NA NA NA hsa-miR-126-5p TGFBR1 0.41765430251855 0.0753161203651532 -0.251712186913126 0.256800460803047 mirMAP;miRNATAP -0.196953631979334 0.00365598115607916 NA NA NA hsa-miR-128-3p TGFBR1 0.98280381420517 5.77641850797209e-05 -0.251712186913126 0.256800460803047 miRNAWalker2_validate;miRTarBase -0.244707904105477 0.000113112751777729 NA NA NA hsa-miR-130b-3p TGFBR1 1.32714007211004 4.78676252285191e-05 -0.251712186913126 0.256800460803047 miRNATAP -0.1828131710731 0.000100953415159321 NA NA NA hsa-miR-140-5p TGFBR1 0.208193069681326 0.303002433893804 -0.251712186913126 0.256800460803047 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.231595932892087 0.00360519586226147 NA NA NA hsa-miR-142-5p TGFBR1 1.55592486377018 6.69269968016779e-06 -0.251712186913126 0.256800460803047 mirMAP -0.145948144144052 0.00101240741188477 NA NA NA hsa-miR-32-3p TGFBR1 0.583525764322974 0.11837203008551 -0.251712186913126 0.256800460803047 mirMAP;miRNATAP -0.12860507498816 0.006711968086731 NA NA NA hsa-miR-330-3p TGFBR1 0.798460296022179 0.00746538156533435 -0.251712186913126 0.256800460803047 mirMAP;miRNATAP -0.202440596846935 0.000103947872399532 NA NA NA hsa-miR-429 TGFBR1 1.40182602301928 0.00900426780286475 -0.251712186913126 0.256800460803047 miRanda;miRNATAP -0.103531890165161 0.000330036442446001 NA NA NA hsa-miR-769-5p TGFBR1 1.14821899306381 1.27143750879772e-06 -0.251712186913126 0.256800460803047 PITA;miRNATAP -0.21341868517347 0.00105603441804849 NA NA NA hsa-miR-106a-5p TGFBR2 -0.173255688252641 0.642872703263671 -1.33119725044149 0.000132508513351042 miRTarBase;miRNATAP -0.226320359125897 0.00077804442165382 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 1.70863907461894 2.04074794107142e-08 -1.33119725044149 0.000132508513351042 miRNATAP -0.400888260139363 2.94525271112196e-07 NA NA NA hsa-miR-130a-3p TGFBR2 0.146223920674657 0.633739795905839 -1.33119725044149 0.000132508513351042 miRNATAP -0.427886145251413 1.09487440025064e-07 NA NA NA hsa-miR-130b-3p TGFBR2 1.32714007211004 4.78676252285191e-05 -1.33119725044149 0.000132508513351042 miRNAWalker2_validate;miRNATAP -0.329348888087832 1.10224858433269e-05 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 1.65862087862483 8.45603406215941e-08 -1.33119725044149 0.000132508513351042 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.344035070546453 9.8957948491363e-06 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-18a-5p TGFBR2 2.20211504140984 1.78678887916334e-09 -1.33119725044149 0.000132508513351042 miRNAWalker2_validate -0.233498338363247 0.000370839906771444 NA NA NA hsa-miR-19b-3p TGFBR2 0.759818275708988 0.00652779573186786 -1.33119725044149 0.000132508513351042 miRNAWalker2_validate;miRNATAP -0.245361262248594 0.00658859699698292 NA NA NA hsa-miR-20a-5p TGFBR2 1.4503375861709 5.7813456424762e-07 -1.33119725044149 0.000132508513351042 miRNAWalker2_validate;miRTarBase;miRNATAP -0.323999105962337 0.000116784197797681 NA NA NA hsa-miR-23a-3p TGFBR2 1.10685926969665 3.16223452471768e-08 -1.33119725044149 0.000132508513351042 miRNATAP -0.801195046416303 1.19427456267555e-11 NA NA NA hsa-miR-23b-3p TGFBR2 -0.286465516491361 0.18664668472995 -1.33119725044149 0.000132508513351042 miRNATAP -0.449425647160368 0.00012654828770299 NA NA NA hsa-miR-301a-3p TGFBR2 1.44721900431161 6.35068481036652e-06 -1.33119725044149 0.000132508513351042 miRNATAP -0.365169880396282 1.34130255394917e-06 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-320b TGFBR2 1.11183660885284 0.000497971211648503 -1.33119725044149 0.000132508513351042 miRanda;miRNATAP -0.260382110270946 0.000825284330358438 NA NA NA hsa-miR-335-3p TGFBR2 2.5197689063267 2.20084506976733e-09 -1.33119725044149 0.000132508513351042 mirMAP -0.211651995421728 0.000195672473367393 NA NA NA hsa-miR-33a-3p TGFBR2 0.347011402017138 0.321709379745392 -1.33119725044149 0.000132508513351042 mirMAP -0.279930982457639 0.000205915700583289 NA NA NA hsa-miR-34c-5p TGFBR2 2.20632574870337 0.000379662996168678 -1.33119725044149 0.000132508513351042 miRanda -0.281900640241328 9.20313386230208e-14 NA NA NA hsa-miR-590-3p TGFBR2 1.11654983899947 0.000160782154924864 -1.33119725044149 0.000132508513351042 miRanda -0.270662071596108 0.00128102617583729 NA NA NA hsa-miR-590-5p TGFBR2 1.04171442093217 0.000272475544954865 -1.33119725044149 0.000132508513351042 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.429974806304296 4.84095482585984e-07 NA NA NA hsa-miR-9-3p TGFBR2 0.330346058941473 0.541111939982661 -1.33119725044149 0.000132508513351042 miRNATAP -0.24679581591473 1.8898130718455e-07 NA NA NA hsa-miR-9-5p TGFBR2 -0.195328736653048 0.761470692992178 -1.33119725044149 0.000132508513351042 miRNATAP -0.190654791604636 6.1026585044985e-07 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 1.2209325870225 6.8757197708107e-06 -1.33119725044149 0.000132508513351042 miRNAWalker2_validate -0.454055744142823 3.73583294489171e-07 NA NA NA hsa-miR-93-5p TGFBR2 1.7515174434778 1.59386482413883e-08 -1.33119725044149 0.000132508513351042 miRNAWalker2_validate;miRNATAP -0.38955660370349 3.98089061392563e-07 NA NA NA hsa-miR-16-5p TRAF6 1.00515772948091 5.33912942007619e-06 -0.299191451402075 0.0475735327593859 MirTarget -0.171653618131396 0.000309124326498109 NA NA NA hsa-miR-320b TRAF6 1.11183660885284 0.000497971211648503 -0.299191451402075 0.0475735327593859 miRanda -0.108566608874949 0.000987342514467968 NA NA NA