miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-5p AIFM1 -0.189422992330471 0.651878220048983 0.566138522069976 0.105763268412712 miRNATAP -0.161261245245166 0.000699421266431265 NA NA NA hsa-miR-125b-5p AKT1 -2.01187572101832 0.00516480893645494 0.109662878488624 0.665605033724525 miRNAWalker2_validate;miRTarBase -0.0542168689976511 0.00588247075121236 NA NA NA hsa-miR-214-3p AKT2 -0.0142082886005279 0.985841603014084 -0.085869348523433 0.771267331146998 mirMAP -0.0534816783927397 0.0102703602750964 NA NA NA hsa-miR-106a-5p AKT3 3.98693608217557 9.37722470816656e-07 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.122915747534173 0.0211707835743014 NA NA NA hsa-miR-106b-5p AKT3 2.80565545918114 1.14547999022566e-09 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.411504731855899 9.49650030459631e-06 NA NA NA hsa-miR-142-3p AKT3 4.35304505457969 3.10014573651358e-10 -3.32677676487603 1.45486698220293e-05 miRanda -0.161022651130634 0.00933730307368185 NA NA NA hsa-miR-15a-5p AKT3 2.0535411006904 1.91108976398046e-06 -3.32677676487603 1.45486698220293e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.374578960806042 0.000213935533400346 NA NA NA hsa-miR-15b-5p AKT3 3.32329949959268 8.40210501034588e-13 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.254367737995205 0.00570754876367863 NA NA NA hsa-miR-16-5p AKT3 2.93575808220754 2.15436817162977e-10 -3.32677676487603 1.45486698220293e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309870666150618 0.000864570425925272 NA NA NA hsa-miR-17-5p AKT3 2.3269271449522 2.13987445663942e-05 -3.32677676487603 1.45486698220293e-05 TargetScan;miRNATAP -0.174632371966135 0.0291369962045925 NA NA NA hsa-miR-20b-5p AKT3 4.5662923200279 4.75238200639144e-05 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.0942515267043283 0.0149862494647445 NA NA NA hsa-miR-29b-2-5p AKT3 -0.596051745078872 0.189540844841389 -3.32677676487603 1.45486698220293e-05 mirMAP -0.233312651843654 0.0174700497895885 NA NA NA hsa-miR-29b-3p AKT3 0.666547117072858 0.234055379278093 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.283935483475042 0.000311340903637634 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 2.14185373842821 0.0609400502269891 -3.32677676487603 1.45486698220293e-05 mirMAP -0.221762461081726 2.87831776854007e-06 NA NA NA hsa-miR-362-3p AKT3 0.679952485897744 0.226148468488576 -3.32677676487603 1.45486698220293e-05 miRanda -0.254988730314174 0.00123561088951897 NA NA NA hsa-miR-501-3p AKT3 1.72239979688923 0.0075900263732748 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.18288683695833 0.00732967244086728 NA NA NA hsa-miR-502-3p AKT3 -0.102232623565007 0.80889202592629 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.229135660673546 0.0306493790797631 NA NA NA hsa-miR-93-5p AKT3 2.65964181833033 2.58315947526774e-08 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.334744595445174 0.000214241376596223 NA NA NA hsa-miR-155-5p APAF1 2.81443182173772 7.42530504828797e-05 0.351537995191827 0.33130839684909 miRNAWalker2_validate -0.105119871128062 0.000202319072259625 22996741;26877850 MiR 155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf 1 expression; The objective of this study is to verify the hypothesis based on the results of bioinformatics analysis that miR-155 modulates cellular apoptosis and DNA damage through the regulation of Apaf-1 and is thus involved in the development and progression of lung cancer; First we measured the expression of miR-155 and the Apaf-1 protein in lung cancer tissues; The results showed that expression of miR-155 was significantly higher in lung cancer tissues than in paracancerous and normal tissues; whereas Apaf-1 expression was lower in the lung cancerous tissues; The results showed that relative to controls the silencing of miR-155 resulted in elevated expression of the Apaf-1 protein whereas Apaf-1 mRNA levels remained unchanged; Both the silencing of miR-155 and the overexpression Apaf-1 greatly increased the sensitivity of A549 cells to cisplatin treatment as evidenced by elevated rates of apoptosis and DNA damage; Furthermore dual-transfection of A549 cells with miR-155 siRNA and Apaf-1 siRNA resulted in the attenuation of apoptosis and DNA damage;Also increase in the transcript level of APAF-1 and CASP-9 after downregulation of miR-21 and miR-155 might indicate that these genes were targeted by aforementioned miRNAs in T47D cells progression; lung cancer;breast cancer hsa-miR-23a-3p APAF1 0.925125296618358 0.0127293543936914 0.351537995191827 0.33130839684909 miRNATAP -0.249229585742285 6.24449355106243e-06 24992592;24249161 Luciferase assay was performed to verify a putative target site of miR-23a in the 3'-UTR of apoptosis protease activating factor 1 APAF1 mRNA; The expression levels of miR-23a and APAF1 in CRC cell lines SW480 and SW620 and clinical samples were assessed using reverse transcription-quantitative real-time PCR RT-qPCR and Western blot; Moreover miR-23a up-regulation was coupled with APAF1 down-regulation in CRC tissue samples;We found that the expression of miR-23a was increased and the level of apoptosis-activating factor-1 APAF-1 was decreased in 5-FU-treated colon cancer cells compared to untreated cells; APAF-1 as a target gene of miR-23a was identified and miR-23a antisense-induced increase in the activation of caspase-9 was observed ; colorectal cancer;colorectal cancer hsa-miR-23b-3p APAF1 -0.581135273821923 0.190478897170459 0.351537995191827 0.33130839684909 miRNATAP -0.161636616309506 0.000480979993890262 NA NA NA hsa-miR-27a-3p APAF1 1.76094007417453 0.000216137556256765 0.351537995191827 0.33130839684909 miRNATAP -0.178590051704588 2.61315263276561e-05 NA NA NA hsa-miR-27b-3p APAF1 -0.0929089601968123 0.85847352206581 0.351537995191827 0.33130839684909 miRNATAP -0.157888261033241 5.61389496165659e-05 NA NA NA hsa-miR-33a-3p APAF1 2.06269680799532 0.00156436055383943 0.351537995191827 0.33130839684909 mirMAP -0.0646710975616299 0.0392982265744757 NA NA NA hsa-miR-374b-5p APAF1 -0.114749866169918 0.764888930049438 0.351537995191827 0.33130839684909 mirMAP -0.131472896885655 0.0153106888263216 NA NA NA hsa-miR-590-3p APAF1 2.35429565068338 2.79601879608564e-06 0.351537995191827 0.33130839684909 PITA;miRanda;mirMAP;miRNATAP -0.117753147962954 0.00340114353110643 NA NA NA hsa-miR-590-5p APAF1 1.51400888103768 0.0023888567923017 0.351537995191827 0.33130839684909 miRanda -0.101026476650395 0.0138258431833649 NA NA NA hsa-miR-664a-3p APAF1 0.249882351950296 0.56171157318348 0.351537995191827 0.33130839684909 mirMAP -0.112670001001515 0.0191425604229765 NA NA NA hsa-miR-708-3p APAF1 0.781444321399141 0.290645825716608 0.351537995191827 0.33130839684909 mirMAP -0.116215085120532 2.19939409004865e-05 NA NA NA hsa-miR-18a-5p ATM 3.90770175770219 9.15298615034137e-10 -0.658961239426083 0.11688259993407 miRNAWalker2_validate;miRTarBase;MirTarget -0.0955169670059363 0.00847777560977354 25963391;23437304;23857602;23229340 However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression cervical and endocervical cancer;colorectal cancer;breast cancer;colon cancer hsa-miR-19b-3p ATM 1.67581705793313 0.000858910586302716 -0.658961239426083 0.11688259993407 miRNAWalker2_validate -0.0951764942208065 0.0445347993663298 NA NA NA hsa-miR-203a-3p ATM 6.35084246337388 7.89944323347948e-08 -0.658961239426083 0.11688259993407 MirTarget -0.10711538788314 2.54510630277939e-08 24145123;27542403 miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression drug resistance;metastasis colorectal cancer;gastric cancer hsa-miR-27a-5p ATM 1.44543293228138 0.039420863458837 -0.658961239426083 0.11688259993407 MirTarget -0.118013745915902 0.000461560887135157 NA NA NA hsa-miR-30e-3p ATM -0.0362193022195196 0.932577027239525 -0.658961239426083 0.11688259993407 mirMAP -0.157523794415466 0.00510124349387628 NA NA NA hsa-miR-335-3p ATM 1.19503568251824 0.0938852560631551 -0.658961239426083 0.11688259993407 mirMAP -0.074282956260848 0.0260513200666591 NA NA NA hsa-miR-339-5p ATM 1.23326828594484 0.0307501214818698 -0.658961239426083 0.11688259993407 miRanda -0.155925656284305 0.000170742871820193 NA NA NA hsa-miR-34c-5p ATM 2.64675661251039 0.0157394735757952 -0.658961239426083 0.11688259993407 miRanda -0.0537433025113812 0.0128732939216326 NA NA NA hsa-miR-590-3p ATM 2.35429565068338 2.79601879608564e-06 -0.658961239426083 0.11688259993407 miRanda;mirMAP -0.116855353539329 0.0127249502757536 NA NA NA hsa-miR-590-5p ATM 1.51400888103768 0.0023888567923017 -0.658961239426083 0.11688259993407 mirMAP -0.134411712770607 0.00484636149427119 NA NA NA hsa-miR-92a-3p ATM 1.87892405805529 1.27013821556583e-05 -0.658961239426083 0.11688259993407 miRNAWalker2_validate -0.13971001344258 0.0112632537340507 NA NA NA hsa-miR-944 ATM 7.20925181386398 0.000823207457340648 -0.658961239426083 0.11688259993407 mirMAP -0.0757915675989751 1.24219656551038e-08 NA NA NA hsa-miR-127-3p BAD -1.3824388460045 0.0732002041209873 -0.429377802397775 0.27401025080212 miRanda;miRNATAP -0.057841230301014 0.0443167062020096 NA NA NA hsa-miR-15b-3p BCL2 3.57530146629867 5.89922785773482e-11 -3.06316187948847 1.08810932834372e-05 mirMAP -0.160794111441143 0.0242966623676607 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-15b-5p BCL2 3.32329949959268 8.40210501034588e-13 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase -0.184030432349379 0.0279332632156109 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-16-2-3p BCL2 3.79845098071094 1.49120139344659e-13 -3.06316187948847 1.08810932834372e-05 mirMAP -0.198780086628007 0.00813011841160033 NA NA NA hsa-miR-16-5p BCL2 2.93575808220754 2.15436817162977e-10 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase -0.272628063312585 0.00124978896318138 21336967;24447552;18449891;25435430;24598659;18931683;22966344;25623762 P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells ;worse prognosis;drug resistance;;;;poor survival;drug resistance liver cancer;lymphoma;gastric cancer;lung cancer;lymphoma;prostate cancer;pancreatic cancer;colon cancer hsa-miR-192-5p BCL2 1.77716187978541 0.113485496183047 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate -0.12938914604432 0.00025104427176319 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-200a-5p BCL2 6.52092140839401 5.73108242597059e-22 -3.06316187948847 1.08810932834372e-05 mirMAP -0.195494336988318 0.000366255804733623 NA NA NA hsa-miR-200b-3p BCL2 5.56167217794639 6.43540045061709e-16 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase;TargetScan;mirMAP -0.114344876372448 0.0393261839456269 NA NA NA hsa-miR-200b-5p BCL2 6.81954246537908 6.31100593281326e-24 -3.06316187948847 1.08810932834372e-05 mirMAP -0.203388603979853 0.000189900674957038 NA NA NA hsa-miR-200c-3p BCL2 6.47012025883743 2.64500707716408e-26 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase;mirMAP -0.20320611228092 0.000726337324039896 NA NA NA hsa-miR-20a-3p BCL2 1.9920766549842 0.000624458530894697 -3.06316187948847 1.08810932834372e-05 mirMAP -0.156783828679669 0.0221974244583471 NA NA NA hsa-miR-21-5p BCL2 2.65163477806992 6.72089787690756e-16 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase -0.480047476048455 4.4710057406991e-05 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-215-5p BCL2 3.66990923176752 0.00294614570694381 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate -0.141357634568995 9.14425263109844e-06 NA NA NA hsa-miR-24-2-5p BCL2 2.06986947133452 5.98496897647448e-05 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase -0.362853470345382 1.94710618153458e-06 NA NA NA hsa-miR-3065-5p BCL2 2.14185373842821 0.0609400502269891 -3.06316187948847 1.08810932834372e-05 mirMAP -0.167248667776853 0.000110489568744755 NA NA NA hsa-miR-32-3p BCL2 2.20477794939766 0.0392771274032852 -3.06316187948847 1.08810932834372e-05 mirMAP -0.159593080869614 0.0156381562883728 NA NA NA hsa-miR-338-5p BCL2 -0.108304629897487 0.894675560494607 -3.06316187948847 1.08810932834372e-05 PITA -0.15384518087035 0.00172699574421937 NA NA NA hsa-miR-33b-5p BCL2 4.77891217497671 1.33695107675057e-08 -3.06316187948847 1.08810932834372e-05 miRTarBase;mirMAP -0.121788561427641 0.00899184402309845 NA NA NA hsa-miR-365a-3p BCL2 0.25545896241765 0.654320504621012 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase -0.394898362577108 1.10607300598646e-08 NA NA NA hsa-miR-375 BCL2 3.3784490463318 0.0449946294355695 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate -0.0605495883559216 0.0103495837966319 26381132;26697569;25613180 The levels of miR-375 Bax and Bcl-2 protein expression in treated cells were determined by Western blot and RT-PCR; Moreover compared to control group the expression of Bcl-2 and miR-375 decreases with formononetin in the U2OS cells while Bax increases;Exosome Carried microRNA 375 Inhibits Cell Progression and Dissemination via Bcl 2 Blocking in Colon Cancer; RT-PCR for Bcl-2 expression showed that Bcl-2 is down-regulated for miR-375 inhibitor and up-regulated for the miR-375 mimic a result confirmed by Western blotting; The present study brings to the forefront new data that suggest miR-375 as a new player in controlling the pathways responsible for inhibiting the natural history of CRC tumor cells via the Bcl-2 pathway;mRNA levels of ERα Bcl-2 and miR-375 were quantified using real-time polymerase chain reaction; After treatment with biochanin A ERα miR-375 and Bcl-2 expression was significantly upregulated ;progression; sarcoma;colon cancer;breast cancer hsa-miR-429 BCL2 6.39965293994036 1.96920201593608e-18 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase;PITA;mirMAP -0.160807368066818 0.00180825818683377 23999873;26513239;26511969 MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation ;; esophageal cancer;gastric cancer;glioblastoma hsa-miR-451a BCL2 0.94904779122044 0.43831018127931 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase -0.0662612159631306 0.0426638129286126 26516138;23053883 Western blot was used for the detection of the protein expression of Bcl-2 and Caspase 3 after the transfection of miR-451 mimics /inhibitors; Bioinformatics analysis demonstrated that Bcl-2 protein is a potential target gene for miR-451; Increased miR-451 expression may negatively regulate Bcl-2 mRNA and protein expression followed by affecting the protein expression of caspase 3 and accelerate the apoptosis in breast cancer indicating that miR-451 might influence the drug resistances of the Paclitaxel-resistant breast cancer cell line;The expression of miR-451 was analyzed by RT-PCR and the expressions of Bcl-2 AKT and phosphorylated AKT were analyzed by Western blotting; In comparison to the controls a significant increase in the expression of miR-451 was associated with significantly decreased expressions of Bcl-2 AKT and p-AKT and a significant increase in the apoptosis rate drug resistance; breast cancer;esophageal cancer hsa-miR-582-5p BCL2 0.685177900016753 0.447761540297692 -3.06316187948847 1.08810932834372e-05 PITA -0.134818080111642 0.00230990489507861 NA NA NA hsa-miR-590-5p BCL2 1.51400888103768 0.0023888567923017 -3.06316187948847 1.08810932834372e-05 miRanda -0.172313035131195 0.0324504248838897 NA NA NA hsa-miR-629-5p BCL2 1.57164125641392 0.0115716388531198 -3.06316187948847 1.08810932834372e-05 mirMAP -0.253306211867568 7.16586879182246e-05 NA NA NA hsa-miR-7-5p BCL2 3.59831747997243 0.000676336260217879 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase;mirMAP -0.1242073018915 0.00724600894737725 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-let-7a-5p BCL2L1 0.148081801547773 0.645305441523746 0.387849298249143 0.372559860651897 TargetScan;miRNATAP -0.195706921705561 0.0127364961268026 26915294;20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA poor survival; lung cancer;liver cancer hsa-miR-23b-3p BCL2L1 -0.581135273821923 0.190478897170459 0.387849298249143 0.372559860651897 miRNAWalker2_validate -0.114245727673024 0.0417114260085146 NA NA NA hsa-miR-342-3p BCL2L1 1.31107714473009 0.0207211910724662 0.387849298249143 0.372559860651897 PITA;miRanda;miRNATAP -0.126863966321354 0.00344426702929298 NA NA NA hsa-miR-342-5p BCL2L1 1.3865615438184 0.0153598969109545 0.387849298249143 0.372559860651897 miRNATAP -0.10097662976693 0.0190123001585698 NA NA NA hsa-miR-195-3p BIRC3 -2.39100534119332 0.000185405399054065 0.151020658041541 0.885694929117284 mirMAP -0.218510545587541 0.0188439412667207 NA NA NA hsa-miR-20b-3p BIRC3 3.32857825638616 0.0632388433748268 0.151020658041541 0.885694929117284 MirTarget -0.1299107016366 0.0269745198432998 NA NA NA hsa-miR-24-1-5p BIRC3 -0.638925193416348 0.236125310537158 0.151020658041541 0.885694929117284 MirTarget -0.358268151050507 0.00120618170314208 NA NA NA hsa-miR-369-3p BIRC3 0.369191262196168 0.638760863212543 0.151020658041541 0.885694929117284 MirTarget;miRNATAP -0.151649537106439 0.0464762854587219 NA NA NA hsa-miR-664a-3p BIRC3 0.249882351950296 0.56171157318348 0.151020658041541 0.885694929117284 mirMAP -0.279628583632852 0.0463249234296194 NA NA NA hsa-miR-491-5p CAPN1 0.569358547192776 0.313310594748302 1.31250824709003 0.00019342035101578 miRanda -0.146719227529871 4.56515860680285e-05 NA NA NA hsa-miR-107 CAPN2 1.49443409571439 0.000130594521065411 0.651486358651082 0.138715166460298 miRanda -0.126575945598959 0.0486589607111655 NA NA NA hsa-miR-1468-5p CAPN2 -1.63442718498426 0.00779372976116312 0.651486358651082 0.138715166460298 MirTarget -0.20208968575975 4.78335198372869e-07 NA NA NA hsa-miR-20a-3p CAPN2 1.9920766549842 0.000624458530894697 0.651486358651082 0.138715166460298 MirTarget -0.140475332643721 0.000931394416878954 NA NA NA hsa-miR-30a-5p CAPN2 -0.768430903969183 0.320487552854215 0.651486358651082 0.138715166460298 miRNAWalker2_validate -0.076700747492619 0.0173346029450836 NA NA NA hsa-miR-421 CAPN2 1.97624148591545 0.000915838012451138 0.651486358651082 0.138715166460298 miRanda -0.109203106517093 0.0088789695877179 NA NA NA hsa-miR-125b-5p CASP10 -2.01187572101832 0.00516480893645494 0.696594106032744 0.336705522947674 mirMAP -0.153393011039 0.0069590481393416 NA NA NA hsa-miR-129-5p CASP10 -2.66843722411409 0.00695783358331245 0.696594106032744 0.336705522947674 mirMAP -0.0960937691760736 0.0221548490430306 NA NA NA hsa-miR-145-3p CASP10 -2.96172379970881 3.54322064762669e-06 0.696594106032744 0.336705522947674 mirMAP -0.145980722963859 0.0215449695392116 NA NA NA hsa-miR-145-5p CASP10 -3.55505374822025 5.45525288912869e-07 0.696594106032744 0.336705522947674 mirMAP -0.142672601854187 0.0121316350864163 NA NA NA hsa-miR-186-5p CASP10 0.445443449112564 0.185447310527704 0.696594106032744 0.336705522947674 MirTarget;mirMAP -0.256033695965961 0.0409420486316736 NA NA NA hsa-miR-19b-3p CASP10 1.67581705793313 0.000858910586302716 0.696594106032744 0.336705522947674 MirTarget;mirMAP -0.20110867596607 0.0138500173136349 NA NA NA hsa-miR-33a-3p CASP10 2.06269680799532 0.00156436055383943 0.696594106032744 0.336705522947674 mirMAP -0.158658499843864 0.0118123887034831 NA NA NA hsa-miR-361-5p CASP10 0.00649167180664723 0.985202350239079 0.696594106032744 0.336705522947674 miRanda -0.46185739017424 0.000107312796513352 NA NA NA hsa-miR-429 CASP10 6.39965293994036 1.96920201593608e-18 0.696594106032744 0.336705522947674 mirMAP;miRNATAP -0.127001550793225 0.0166709250754597 NA NA NA hsa-miR-501-5p CASP10 1.0411896821345 0.0777206709183552 0.696594106032744 0.336705522947674 mirMAP -0.162656359923242 0.0198896796897625 NA NA NA hsa-miR-532-5p CASP10 -0.297424983759107 0.503934707453099 0.696594106032744 0.336705522947674 mirMAP -0.467593826928243 3.69564958364264e-07 NA NA NA hsa-miR-589-3p CASP10 1.33205316880069 0.052632683806148 0.696594106032744 0.336705522947674 mirMAP -0.229037416486941 0.00012648308689486 NA NA NA hsa-miR-592 CASP10 2.80403350008555 0.0293520213681333 0.696594106032744 0.336705522947674 miRNATAP -0.104832733343847 0.00729546473661119 NA NA NA hsa-miR-744-3p CASP10 1.08385719878174 0.131243679775541 0.696594106032744 0.336705522947674 mirMAP -0.389147042180601 1.93568579672746e-12 NA NA NA hsa-miR-129-5p CASP3 -2.66843722411409 0.00695783358331245 0.933458745854025 0.00553216752849989 mirMAP -0.0534788597606955 0.00601692602724139 23744359 The intrinsic apoptotic pathway triggered by miR-129 was activated by cleavage of caspase-9 and caspase-3 colorectal cancer hsa-miR-193b-5p CASP3 0.448438597554777 0.565875535989548 0.933458745854025 0.00553216752849989 MirTarget -0.0872135008518857 0.000336590710768405 NA NA NA hsa-miR-23a-3p CASP7 0.925125296618358 0.0127293543936914 0.552586925970727 0.214980741147346 MirTarget -0.158059813277252 0.0218528745159853 NA NA NA hsa-miR-335-5p CASP7 0.167216045757305 0.803897055331049 0.552586925970727 0.214980741147346 MirTarget -0.0960881036942394 0.0104886602247102 NA NA NA hsa-miR-361-5p CASP7 0.00649167180664723 0.985202350239079 0.552586925970727 0.214980741147346 PITA;miRanda -0.196491640269563 0.00761577874218848 NA NA NA hsa-miR-664a-3p CASP7 0.249882351950296 0.56171157318348 0.552586925970727 0.214980741147346 MirTarget -0.138008785561072 0.0200924787125557 NA NA NA hsa-miR-217 CASP8 -0.378397407994341 0.717408682071252 1.3830562433264 0.000219303188556801 miRanda -0.0570644247337252 0.00539429935678899 NA NA NA hsa-miR-455-5p CASP8 -0.317715589860275 0.616296031007863 1.3830562433264 0.000219303188556801 miRanda -0.0884608373442649 0.00884269023692156 NA NA NA hsa-miR-222-5p CASP9 2.52056758362407 0.00142010793166944 -0.457357956909619 0.196865877677313 mirMAP -0.0833185190786652 0.000900343675380668 NA NA NA hsa-miR-125a-5p CFLAR -1.32352790615388 0.00714301627309467 0.10975680494869 0.785876903093292 miRanda -0.126729197885069 0.00640094446943848 NA NA NA hsa-miR-130b-3p CFLAR 3.9204771543282 1.2714917955808e-11 0.10975680494869 0.785876903093292 mirMAP -0.136933509317755 0.000311790699059756 NA NA NA hsa-miR-15b-5p CFLAR 3.32329949959268 8.40210501034588e-13 0.10975680494869 0.785876903093292 mirMAP -0.103078703550023 0.0306697621570958 NA NA NA hsa-miR-301a-3p CFLAR 1.99338115332667 0.000813358604963724 0.10975680494869 0.785876903093292 mirMAP -0.142408816847749 0.000173112484747624 NA NA NA hsa-miR-30b-3p CFLAR 0.169674321578618 0.766080356926625 0.10975680494869 0.785876903093292 mirMAP -0.159754908443129 6.83731029154175e-05 NA NA NA hsa-miR-497-5p CFLAR -1.44150596209372 0.0225146607606395 0.10975680494869 0.785876903093292 mirMAP -0.0765829773182167 0.0341522355871089 NA NA NA hsa-miR-708-5p CFLAR 1.70409736218557 0.0319538709865338 0.10975680494869 0.785876903093292 mirMAP -0.064606800237084 0.0242189622775022 NA NA NA hsa-miR-9-5p CFLAR 1.79620806707734 0.14526963042518 0.10975680494869 0.785876903093292 mirMAP -0.0660143770591774 0.000316934882106904 NA NA NA hsa-miR-582-5p CHP2 0.685177900016753 0.447761540297692 1.48109800587141 0.509563690322669 miRNATAP -0.415938249783453 0.0031281915626761 NA NA NA hsa-miR-195-5p CHUK -1.59182537400701 0.0169128463756769 0.414357078402553 0.120851009984769 miRNAWalker2_validate;MirTarget -0.0505524818439462 0.0249303808057043 NA NA NA hsa-miR-497-5p CHUK -1.44150596209372 0.0225146607606395 0.414357078402553 0.120851009984769 MirTarget -0.0738666880299914 0.00184265972449325 NA NA NA hsa-miR-15b-3p CSF2RB 3.57530146629867 5.89922785773482e-11 -0.531949678174437 0.52469724338113 mirMAP -0.243883163153962 0.00378871588753218 NA NA NA hsa-miR-19b-3p CSF2RB 1.67581705793313 0.000858910586302716 -0.531949678174437 0.52469724338113 MirTarget -0.249978645254246 0.00793124384654011 NA NA NA hsa-miR-30b-3p CSF2RB 0.169674321578618 0.766080356926625 -0.531949678174437 0.52469724338113 MirTarget -0.278521035137442 0.000870863627134223 NA NA NA hsa-miR-532-5p CSF2RB -0.297424983759107 0.503934707453099 -0.531949678174437 0.52469724338113 MirTarget -0.217107897448973 0.0443044265716524 NA NA NA hsa-miR-30a-3p DFFA -1.22212086897848 0.167565797592104 0.341684151430155 0.230758125204177 mirMAP -0.0599531777763583 0.000881218975391209 NA NA NA hsa-miR-3913-5p DFFA 0.145645056779437 0.734844256690741 0.341684151430155 0.230758125204177 mirMAP -0.0803660704048619 0.0338526195673376 NA NA NA hsa-miR-628-5p DFFA 1.04832355434705 0.0252368809675445 0.341684151430155 0.230758125204177 mirMAP -0.0726111007421186 0.0358086291777981 NA NA NA hsa-miR-365a-3p DFFB 0.25545896241765 0.654320504621012 -0.125452270886234 0.736775154451074 MirTarget -0.104776615460763 0.00471093454042319 NA NA NA hsa-miR-130b-3p ENDOD1 3.9204771543282 1.2714917955808e-11 -1.15080298333206 0.0185661445984158 MirTarget -0.123811637273732 0.00768158978083829 NA NA NA hsa-miR-16-1-3p ENDOD1 2.83281226969693 7.54359864580834e-09 -1.15080298333206 0.0185661445984158 mirMAP -0.135967312122073 0.0145516003938159 NA NA NA hsa-miR-181a-5p ENDOD1 1.25558293560636 0.00748975499703878 -1.15080298333206 0.0185661445984158 MirTarget -0.187411883595055 0.00155676708701448 NA NA NA hsa-miR-181b-5p ENDOD1 1.11397227523501 0.0273417050354018 -1.15080298333206 0.0185661445984158 MirTarget -0.124628399892827 0.0242297145078638 NA NA NA hsa-miR-181c-5p ENDOD1 -0.302833440762172 0.537532549455539 -1.15080298333206 0.0185661445984158 MirTarget -0.191406533855745 0.000752702169700885 NA NA NA hsa-miR-192-5p ENDOD1 1.77716187978541 0.113485496183047 -1.15080298333206 0.0185661445984158 miRNAWalker2_validate -0.0862367912644295 0.000436304334532624 NA NA NA hsa-miR-19a-3p ENDOD1 2.17020503944519 0.00122084653711062 -1.15080298333206 0.0185661445984158 mirMAP -0.123622385321676 0.00260534190818447 NA NA NA hsa-miR-19b-3p ENDOD1 1.67581705793313 0.000858910586302716 -1.15080298333206 0.0185661445984158 mirMAP -0.160391298766318 0.00360487948297533 NA NA NA hsa-miR-200b-3p ENDOD1 5.56167217794639 6.43540045061709e-16 -1.15080298333206 0.0185661445984158 TargetScan -0.126814654390186 0.000916290413422611 NA NA NA hsa-miR-20a-3p ENDOD1 1.9920766549842 0.000624458530894697 -1.15080298333206 0.0185661445984158 MirTarget -0.0961736436351873 0.0431950757893967 NA NA NA hsa-miR-26b-3p ENDOD1 0.985177548213122 0.0351427970185971 -1.15080298333206 0.0185661445984158 mirMAP -0.154240417208051 0.00986863139851759 NA NA NA hsa-miR-301a-3p ENDOD1 1.99338115332667 0.000813358604963724 -1.15080298333206 0.0185661445984158 MirTarget -0.130559457956406 0.00488088631995514 NA NA NA hsa-miR-3607-3p ENDOD1 1.38015131722213 0.0240067155694847 -1.15080298333206 0.0185661445984158 MirTarget;miRNATAP -0.111811598437114 0.0138513910980642 NA NA NA hsa-miR-3613-5p ENDOD1 4.05007522786126 4.52786477176299e-14 -1.15080298333206 0.0185661445984158 MirTarget -0.201855032650942 4.29102693515804e-05 NA NA NA hsa-miR-362-3p ENDOD1 0.679952485897744 0.226148468488576 -1.15080298333206 0.0185661445984158 miRanda -0.182370207955287 0.000231966663699426 NA NA NA hsa-miR-429 ENDOD1 6.39965293994036 1.96920201593608e-18 -1.15080298333206 0.0185661445984158 miRanda;miRNATAP -0.097834612657931 0.00627134945084786 NA NA NA hsa-miR-454-3p ENDOD1 1.40269869979902 0.00366085847011367 -1.15080298333206 0.0185661445984158 MirTarget -0.233643994119384 4.41462077769692e-05 NA NA NA hsa-miR-589-3p ENDOD1 1.33205316880069 0.052632683806148 -1.15080298333206 0.0185661445984158 mirMAP -0.102713708462806 0.0114984355921255 NA NA NA hsa-miR-589-5p ENDOD1 1.55790780760302 0.000326340665093671 -1.15080298333206 0.0185661445984158 MirTarget -0.177647132185528 0.00560274996532207 NA NA NA hsa-miR-590-3p ENDOD1 2.35429565068338 2.79601879608564e-06 -1.15080298333206 0.0185661445984158 miRanda -0.21562284963162 7.2235803998372e-05 NA NA NA hsa-miR-149-5p EXOG 1.18551753240939 0.197439607622379 -0.0602324359259732 0.858947815339452 MirTarget -0.057531501434243 0.00547587782549892 NA NA NA hsa-miR-24-3p EXOG 1.55853749533999 0.000524726461381821 -0.0602324359259732 0.858947815339452 MirTarget -0.143003272289887 0.000748094007636054 NA NA NA hsa-miR-106a-5p FAS 3.98693608217557 9.37722470816656e-07 -0.344841531633832 0.589341195024639 miRNAWalker2_validate;miRTarBase -0.140227807754695 0.00127753821199214 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-361-5p FAS 0.00649167180664723 0.985202350239079 -0.344841531633832 0.589341195024639 miRanda -0.330419186265804 0.00171930259182594 NA NA NA hsa-miR-590-5p FAS 1.51400888103768 0.0023888567923017 -0.344841531633832 0.589341195024639 miRanda -0.19807034795777 0.00636164081342142 NA NA NA hsa-let-7e-5p FASLG -0.111012524740586 0.814744515884005 1.92790162472903 0.0908475849274605 miRNATAP -0.311690734835121 0.0241590225763419 NA NA NA hsa-miR-199a-5p FASLG -1.24888110793613 0.0747755616523728 1.92790162472903 0.0908475849274605 miRanda -0.398497989415625 1.31601874419318e-05 NA NA NA hsa-miR-28-5p FASLG -0.815636722979196 0.0221199948901761 1.92790162472903 0.0908475849274605 miRanda -0.57816364875664 0.00170836414115334 NA NA NA hsa-miR-324-5p FASLG 1.31253452379847 0.0116806680545163 1.92790162472903 0.0908475849274605 miRanda -0.332106354222357 0.00772738622468345 NA NA NA hsa-miR-92a-3p FASLG 1.87892405805529 1.27013821556583e-05 1.92790162472903 0.0908475849274605 miRNATAP -0.372376902660941 0.0131300678376092 NA NA NA hsa-miR-92b-3p FASLG 1.69303761469782 0.0103484911955574 1.92790162472903 0.0908475849274605 miRNATAP -0.252529060131383 0.00986337973635399 NA NA NA hsa-miR-125a-3p IKBKB -0.0748960586927341 0.920735897434087 0.104177496834708 0.718852918781577 miRanda -0.0852357675484998 7.52794868346709e-05 NA NA NA hsa-miR-129-5p IKBKB -2.66843722411409 0.00695783358331245 0.104177496834708 0.718852918781577 miRanda -0.0519957147341642 0.00170630719140456 NA NA NA hsa-miR-151a-3p IKBKB 0.373902859770645 0.376924505912903 0.104177496834708 0.718852918781577 miRNAWalker2_validate -0.121270812981731 0.00180898875297091 NA NA NA hsa-miR-28-5p IKBKB -0.815636722979196 0.0221199948901761 0.104177496834708 0.718852918781577 miRanda -0.0951913278464738 0.0407859263719251 NA NA NA hsa-miR-324-5p IKBKB 1.31253452379847 0.0116806680545163 0.104177496834708 0.718852918781577 miRanda -0.0877292997579183 0.00508151003146613 NA NA NA hsa-miR-326 IKBKB 1.76645822596029 0.0367310428720192 0.104177496834708 0.718852918781577 miRanda -0.0541006012930947 0.00510430599232433 NA NA NA hsa-miR-330-5p IKBKB 2.25110496739954 0.000275527655397415 0.104177496834708 0.718852918781577 miRanda -0.0599291464122267 0.0219333157998209 NA NA NA hsa-miR-335-5p IKBKB 0.167216045757305 0.803897055331049 0.104177496834708 0.718852918781577 miRNAWalker2_validate -0.069855608034922 0.00389524011198767 NA NA NA hsa-miR-339-5p IKBKB 1.23326828594484 0.0307501214818698 0.104177496834708 0.718852918781577 miRanda -0.112704791185609 7.01383121429463e-05 NA NA NA hsa-miR-542-3p IKBKB -0.376147863244659 0.438002751207043 0.104177496834708 0.718852918781577 miRanda -0.1114840138672 0.000952486304701064 NA NA NA hsa-miR-107 IKBKG 1.49443409571439 0.000130594521065411 0.217673245627403 0.541287587904691 miRanda -0.111167904280604 0.0318178190037609 NA NA NA hsa-miR-125a-5p IKBKG -1.32352790615388 0.00714301627309467 0.217673245627403 0.541287587904691 miRanda -0.110235437146931 0.00712043030373108 NA NA NA hsa-miR-338-5p IKBKG -0.108304629897487 0.894675560494607 0.217673245627403 0.541287587904691 mirMAP -0.107990652303128 1.00066234929907e-05 NA NA NA hsa-miR-432-5p IKBKG -1.04688139137176 0.21678663577335 0.217673245627403 0.541287587904691 mirMAP -0.0643313948553221 0.00714222958480518 NA NA NA hsa-miR-485-3p IKBKG -0.45375554387223 0.581698112994487 0.217673245627403 0.541287587904691 mirMAP -0.0586573352893445 0.0180067744933081 NA NA NA hsa-miR-181c-5p IL1A -0.302833440762172 0.537532549455539 4.31599389135009 0.0104359859237567 MirTarget -0.750864040262053 0.000127388155916292 NA NA NA hsa-miR-181d-5p IL1A -0.529098579553155 0.325262124523294 4.31599389135009 0.0104359859237567 MirTarget -0.37223349359349 0.0386333962224623 NA NA NA hsa-miR-191-5p IL1A 1.58824208483839 0.000738859004053681 4.31599389135009 0.0104359859237567 miRNAWalker2_validate -0.920302645458858 5.18012425368392e-06 NA NA NA hsa-miR-200a-3p IL1A 6.336081120041 4.024313571871e-16 4.31599389135009 0.0104359859237567 MirTarget -0.461162168953321 7.32399186286365e-05 NA NA NA hsa-miR-30a-5p IL1A -0.768430903969183 0.320487552854215 4.31599389135009 0.0104359859237567 MirTarget -0.52318793715064 2.12283658834032e-05 NA NA NA hsa-miR-30c-5p IL1A 0.38723991118075 0.348605235643473 4.31599389135009 0.0104359859237567 MirTarget -0.489594165506681 0.0381755140143911 NA NA NA hsa-miR-30d-5p IL1A 0.302504510257496 0.380193536606962 4.31599389135009 0.0104359859237567 MirTarget -0.660110352393156 0.0206593654232568 NA NA NA hsa-miR-30e-5p IL1A 0.780047227271616 0.0346714425913016 4.31599389135009 0.0104359859237567 MirTarget -0.622005267690719 0.0186645499145714 NA NA NA hsa-miR-532-5p IL1A -0.297424983759107 0.503934707453099 4.31599389135009 0.0104359859237567 MirTarget -1.49939259880363 1.12516024441561e-12 NA NA NA hsa-miR-30a-3p IL1B -1.22212086897848 0.167565797592104 2.1960788827607 0.0547435829439046 MirTarget -0.188632829792091 0.0100267069441247 NA NA NA hsa-miR-30e-3p IL1B -0.0362193022195196 0.932577027239525 2.1960788827607 0.0547435829439046 MirTarget -0.393879004731287 0.0104599199519738 NA NA NA hsa-miR-130b-5p IL1R1 3.74118449312296 2.92266550966038e-10 -2.02737457884455 0.00137078637258843 mirMAP -0.149452338998095 0.0117092718178299 NA NA NA hsa-miR-17-3p IL1R1 1.2477858204856 0.00186593270231258 -2.02737457884455 0.00137078637258843 mirMAP -0.478550922210701 8.17349650316603e-08 NA NA NA hsa-miR-197-3p IL1R1 1.23723883665376 0.0073292027020411 -2.02737457884455 0.00137078637258843 miRNAWalker2_validate -0.201564995718338 0.0104802978939536 NA NA NA hsa-miR-215-5p IL1R1 3.66990923176752 0.00294614570694381 -2.02737457884455 0.00137078637258843 miRNAWalker2_validate -0.0643687853546978 0.0270156671801882 NA NA NA hsa-miR-24-3p IL1R1 1.55853749533999 0.000524726461381821 -2.02737457884455 0.00137078637258843 miRNATAP -0.159647869062635 0.0480771989300103 NA NA NA hsa-miR-30d-3p IL1R1 -0.0740421896025512 0.857423650167556 -2.02737457884455 0.00137078637258843 mirMAP -0.223115096053911 0.0122273851081666 NA NA NA hsa-miR-335-3p IL1R1 1.19503568251824 0.0938852560631551 -2.02737457884455 0.00137078637258843 mirMAP -0.223081090533626 8.58843025959345e-06 NA NA NA hsa-miR-590-3p IL1R1 2.35429565068338 2.79601879608564e-06 -2.02737457884455 0.00137078637258843 miRanda;miRNATAP -0.147108550432802 0.0393951910177817 NA NA NA hsa-miR-106a-5p IL1RAP 3.98693608217557 9.37722470816656e-07 1.81317515528315 0.0267244199977934 MirTarget -0.218470157967721 9.0151667480019e-05 NA NA NA hsa-miR-107 IL1RAP 1.49443409571439 0.000130594521065411 1.81317515528315 0.0267244199977934 miRanda -0.363722797160927 0.00232718010564673 NA NA NA hsa-miR-129-5p IL1RAP -2.66843722411409 0.00695783358331245 1.81317515528315 0.0267244199977934 miRanda -0.107713155959696 0.0235861697439642 NA NA NA hsa-miR-130b-3p IL1RAP 3.9204771543282 1.2714917955808e-11 1.81317515528315 0.0267244199977934 MirTarget -0.183249700943366 0.0187454649455759 NA NA NA hsa-miR-186-5p IL1RAP 0.445443449112564 0.185447310527704 1.81317515528315 0.0267244199977934 mirMAP -0.718403028369971 2.51603762712787e-07 NA NA NA hsa-miR-190a-5p IL1RAP -0.350028931082571 0.592968026065287 1.81317515528315 0.0267244199977934 MirTarget -0.144190215580799 0.0449552426014772 NA NA NA hsa-miR-192-5p IL1RAP 1.77716187978541 0.113485496183047 1.81317515528315 0.0267244199977934 miRNAWalker2_validate -0.252268654885249 3.56574127396124e-10 NA NA NA hsa-miR-20b-5p IL1RAP 4.5662923200279 4.75238200639144e-05 1.81317515528315 0.0267244199977934 MirTarget -0.178160427060987 1.0452389681559e-05 NA NA NA hsa-miR-215-5p IL1RAP 3.66990923176752 0.00294614570694381 1.81317515528315 0.0267244199977934 miRNAWalker2_validate -0.154148331658159 3.25348220932905e-05 NA NA NA hsa-miR-301a-3p IL1RAP 1.99338115332667 0.000813358604963724 1.81317515528315 0.0267244199977934 MirTarget -0.237604716994952 0.00221832588789205 NA NA NA hsa-miR-335-3p IL1RAP 1.19503568251824 0.0938852560631551 1.81317515528315 0.0267244199977934 mirMAP -0.158786384887794 0.014979120510779 NA NA NA hsa-miR-361-5p IL1RAP 0.00649167180664723 0.985202350239079 1.81317515528315 0.0267244199977934 miRanda -0.504621719246811 0.000189048746747028 NA NA NA hsa-miR-362-3p IL1RAP 0.679952485897744 0.226148468488576 1.81317515528315 0.0267244199977934 miRanda -0.268765999532969 0.00124584358240993 NA NA NA hsa-miR-375 IL1RAP 3.3784490463318 0.0449946294355695 1.81317515528315 0.0267244199977934 miRNAWalker2_validate;miRanda -0.202285910594492 1.49808538529928e-14 NA NA NA hsa-miR-454-3p IL1RAP 1.40269869979902 0.00366085847011367 1.81317515528315 0.0267244199977934 MirTarget -0.212712914200949 0.0280159654989869 NA NA NA hsa-miR-7-1-3p IL1RAP 1.43074343339835 0.00471215970502094 1.81317515528315 0.0267244199977934 MirTarget -0.262830853426143 0.00426933865405271 NA NA NA hsa-miR-93-5p IL1RAP 2.65964181833033 2.58315947526774e-08 1.81317515528315 0.0267244199977934 MirTarget -0.260712964664117 0.00654269721595287 NA NA NA hsa-miR-328-3p IRAK1 -0.405365328300136 0.434443269076833 1.47586984906082 0.000366213324794358 miRNAWalker2_validate -0.106324404811007 0.0206606921552805 NA NA NA hsa-miR-3065-5p IRAK2 2.14185373842821 0.0609400502269891 0.53992460937121 0.48745272926867 mirMAP -0.103253225145944 0.0314194968676248 NA NA NA hsa-miR-335-5p IRAK2 0.167216045757305 0.803897055331049 0.53992460937121 0.48745272926867 miRNAWalker2_validate -0.232052126462868 0.00037873058269171 NA NA NA hsa-miR-616-5p IRAK2 2.48416313933027 0.00318247475868827 0.53992460937121 0.48745272926867 mirMAP -0.166160354450342 0.010912766002755 NA NA NA hsa-miR-141-3p IRAK3 7.30474126597325 1.45115996357606e-24 -1.5911768648261 0.0608932642227986 mirMAP -0.124428028115031 0.0463743787233135 NA NA NA hsa-miR-148b-5p IRAK3 2.80812018666078 3.97536665756679e-08 -1.5911768648261 0.0608932642227986 mirMAP -0.192848075625996 0.0383289566152002 NA NA NA hsa-miR-188-5p IRAK3 1.39111178824125 0.0251592818948912 -1.5911768648261 0.0608932642227986 mirMAP -0.166621442051754 0.0329678668361846 NA NA NA hsa-miR-205-5p IRAK3 8.08298115900323 3.83045179398654e-07 -1.5911768648261 0.0608932642227986 mirMAP -0.0801282845485372 0.00673841950642464 NA NA NA hsa-miR-20a-3p IRAK3 1.9920766549842 0.000624458530894697 -1.5911768648261 0.0608932642227986 mirMAP -0.261465893520975 0.00147408885342381 NA NA NA hsa-miR-3200-3p IRAK3 2.3251191657063 0.0140310042534957 -1.5911768648261 0.0608932642227986 mirMAP -0.154032322884487 0.00255901964782929 NA NA NA hsa-miR-324-5p IRAK3 1.31253452379847 0.0116806680545163 -1.5911768648261 0.0608932642227986 miRanda -0.193856000696009 0.0372260087794947 NA NA NA hsa-miR-361-5p IRAK3 0.00649167180664723 0.985202350239079 -1.5911768648261 0.0608932642227986 miRanda;mirMAP -0.365282147434525 0.00952444469992107 NA NA NA hsa-miR-421 IRAK3 1.97624148591545 0.000915838012451138 -1.5911768648261 0.0608932642227986 miRanda;mirMAP -0.243149449692798 0.00257706348366609 NA NA NA hsa-miR-429 IRAK3 6.39965293994036 1.96920201593608e-18 -1.5911768648261 0.0608932642227986 miRanda -0.177229769626644 0.00434710987093182 NA NA NA hsa-miR-501-5p IRAK3 1.0411896821345 0.0777206709183552 -1.5911768648261 0.0608932642227986 mirMAP -0.322048750119535 7.47349631798561e-05 NA NA NA hsa-miR-590-3p IRAK3 2.35429565068338 2.79601879608564e-06 -1.5911768648261 0.0608932642227986 miRanda;mirMAP -0.187032574953831 0.0496821229977895 NA NA NA hsa-miR-590-5p IRAK3 1.51400888103768 0.0023888567923017 -1.5911768648261 0.0608932642227986 mirMAP -0.216156703633012 0.0258318612322778 NA NA NA hsa-miR-660-5p IRAK3 -0.0668683798854808 0.885250178390404 -1.5911768648261 0.0608932642227986 mirMAP -0.331093437975956 0.0016025474932389 NA NA NA hsa-miR-708-3p IRAK3 0.781444321399141 0.290645825716608 -1.5911768648261 0.0608932642227986 mirMAP -0.165276578665181 0.0113404566494659 NA NA NA hsa-miR-9-3p IRAK3 1.69328215716742 0.125170982657059 -1.5911768648261 0.0608932642227986 mirMAP -0.157203774120566 0.000355966379034606 NA NA NA hsa-miR-92a-3p IRAK3 1.87892405805529 1.27013821556583e-05 -1.5911768648261 0.0608932642227986 mirMAP -0.317244142926089 0.00448492815917761 NA NA NA hsa-miR-944 IRAK3 7.20925181386398 0.000823207457340648 -1.5911768648261 0.0608932642227986 mirMAP -0.0588283272845158 0.0330956630677375 NA NA NA hsa-miR-193a-3p IRAK4 0.646392169474854 0.207134343676122 0.276224247443857 0.306973017403332 miRanda -0.102433012412476 0.000571205505589283 NA NA NA hsa-miR-217 IRAK4 -0.378397407994341 0.717408682071252 0.276224247443857 0.306973017403332 miRanda -0.0505421332909068 0.000512308160539177 NA NA NA hsa-miR-30a-3p IRAK4 -1.22212086897848 0.167565797592104 0.276224247443857 0.306973017403332 mirMAP -0.0559612305871504 0.00104930026969389 NA NA NA hsa-miR-30d-3p IRAK4 -0.0740421896025512 0.857423650167556 0.276224247443857 0.306973017403332 mirMAP -0.0746699193523077 0.0465068386733909 NA NA NA hsa-miR-320b IRAK4 0.20205459771295 0.727216419960509 0.276224247443857 0.306973017403332 miRanda -0.062672461311766 0.0175914581171038 NA NA NA hsa-miR-106b-5p MAP3K14 2.80565545918114 1.14547999022566e-09 -0.572095255643433 0.232052277296526 MirTarget -0.147103803660124 0.0107438423053429 NA NA NA hsa-miR-17-5p MAP3K14 2.3269271449522 2.13987445663942e-05 -0.572095255643433 0.232052277296526 MirTarget -0.154710364889365 0.00157167780275142 NA NA NA hsa-miR-345-5p MAP3K14 2.77314563304336 4.34343702412489e-05 -0.572095255643433 0.232052277296526 MirTarget -0.103524963377024 0.00878161781449097 NA NA NA hsa-miR-429 MAP3K14 6.39965293994036 1.96920201593608e-18 -0.572095255643433 0.232052277296526 miRNATAP -0.116936681153463 0.000784919148104685 NA NA NA hsa-miR-93-5p MAP3K14 2.65964181833033 2.58315947526774e-08 -0.572095255643433 0.232052277296526 MirTarget -0.2276783161594 3.94079758590909e-05 NA NA NA hsa-miR-491-5p MYD88 0.569358547192776 0.313310594748302 1.04996381894084 0.00608020423443673 miRanda -0.0928684923539095 0.0181157256220584 NA NA NA hsa-miR-129-5p NFKB1 -2.66843722411409 0.00695783358331245 -0.0840135656355585 0.835893045732549 PITA;miRanda -0.0812972463102185 0.000478558238868362 NA NA NA hsa-miR-338-3p NFKB1 0.447551118940466 0.558485097370031 -0.0840135656355585 0.835893045732549 miRanda -0.0813922131060428 0.00657287754364809 NA NA NA hsa-miR-429 NFKB1 6.39965293994036 1.96920201593608e-18 -0.0840135656355585 0.835893045732549 miRanda;miRNATAP -0.073509791531356 0.0128778728622437 NA NA NA hsa-miR-450b-5p NFKB1 0.445103105471153 0.416021465008949 -0.0840135656355585 0.835893045732549 MirTarget;PITA -0.0834463917197502 0.0479361396360916 NA NA NA hsa-miR-508-3p NFKB1 0.975099105064348 0.439528954969797 -0.0840135656355585 0.835893045732549 MirTarget;PITA;miRNATAP -0.0599456774380201 0.00102242124383691 NA NA NA hsa-miR-129-5p NFKBIA -2.66843722411409 0.00695783358331245 -0.700104460662981 0.124399544894923 miRanda -0.0743146001923094 0.00473976292369497 NA NA NA hsa-miR-335-5p NFKBIA 0.167216045757305 0.803897055331049 -0.700104460662981 0.124399544894923 miRNAWalker2_validate -0.0846004358010369 0.0278754657292832 NA NA NA hsa-let-7g-5p NGF 0.857251702023746 0.00647597344297273 -4.9479894848305 8.79599085267218e-05 MirTarget -0.75463687244667 0.00128893578106286 NA NA NA hsa-miR-429 NGF 6.39965293994036 1.96920201593608e-18 -4.9479894848305 8.79599085267218e-05 miRanda -0.370250673166168 6.50680322666926e-05 NA NA NA hsa-miR-146b-5p PIK3CA 1.87569569182453 0.000737241069698886 0.514328426212782 0.248930105421785 mirMAP -0.104188309355891 0.0214970111401642 NA NA NA hsa-miR-148a-5p PIK3CA 1.31769244477686 0.0507400532963856 0.514328426212782 0.248930105421785 mirMAP -0.0944646397173182 0.0115647584846813 NA NA NA hsa-miR-148b-3p PIK3CA 1.75622244535669 8.84414356040579e-08 0.514328426212782 0.248930105421785 miRNAWalker2_validate -0.244141801200414 0.00147579635788138 NA NA NA hsa-miR-186-5p PIK3CA 0.445443449112564 0.185447310527704 0.514328426212782 0.248930105421785 mirMAP -0.280960133798979 0.000232701716483115 NA NA NA hsa-miR-29b-1-5p PIK3CA 0.33698032160171 0.598092174563471 0.514328426212782 0.248930105421785 mirMAP -0.12089066483943 0.00233700941849917 NA NA NA hsa-miR-320a PIK3CA -0.912036444869976 0.0565555443926988 0.514328426212782 0.248930105421785 miRanda -0.128981884483952 0.0152314868443974 NA NA NA hsa-miR-320b PIK3CA 0.20205459771295 0.727216419960509 0.514328426212782 0.248930105421785 miRanda -0.121444800770151 0.00550932456475504 NA NA NA hsa-miR-320c PIK3CA -0.10618808730545 0.854002814666472 0.514328426212782 0.248930105421785 miRanda -0.095546750594827 0.033173734759664 NA NA NA hsa-miR-335-3p PIK3CA 1.19503568251824 0.0938852560631551 0.514328426212782 0.248930105421785 mirMAP -0.0953287573084171 0.00699869512990194 NA NA NA hsa-miR-335-5p PIK3CA 0.167216045757305 0.803897055331049 0.514328426212782 0.248930105421785 miRNAWalker2_validate -0.124494566731403 0.000883627732385134 NA NA NA hsa-miR-338-5p PIK3CA -0.108304629897487 0.894675560494607 0.514328426212782 0.248930105421785 mirMAP -0.108048495334147 0.00046563589386498 NA NA NA hsa-miR-339-5p PIK3CA 1.23326828594484 0.0307501214818698 0.514328426212782 0.248930105421785 miRanda -0.13798173006655 0.00178425799549926 NA NA NA hsa-miR-501-5p PIK3CA 1.0411896821345 0.0777206709183552 0.514328426212782 0.248930105421785 mirMAP -0.120904681333791 0.00473986403400753 NA NA NA hsa-miR-590-3p PIK3CA 2.35429565068338 2.79601879608564e-06 0.514328426212782 0.248930105421785 miRanda;mirMAP -0.12312207550598 0.0133629325751335 NA NA NA hsa-miR-96-5p PIK3CA 5.62521466029286 1.54938806718028e-10 0.514328426212782 0.248930105421785 TargetScan -0.0800758401784978 0.018941263754853 NA NA NA hsa-miR-130a-3p PIK3CB 0.176861046122832 0.7577473016872 0.897158330473952 0.0125840363244796 miRNATAP -0.116582529549782 0.00106378240800672 NA NA NA hsa-miR-19a-3p PIK3CB 2.17020503944519 0.00122084653711062 0.897158330473952 0.0125840363244796 miRNATAP -0.0945374098728659 0.00169825908570542 NA NA NA hsa-miR-19b-3p PIK3CB 1.67581705793313 0.000858910586302716 0.897158330473952 0.0125840363244796 miRNATAP -0.110401307134748 0.00639042894521705 NA NA NA hsa-miR-29a-3p PIK3CB -0.638239697975974 0.251923581881716 0.897158330473952 0.0125840363244796 miRNATAP -0.098181382528792 0.00755530773900116 NA NA NA hsa-miR-29b-3p PIK3CB 0.666547117072858 0.234055379278093 0.897158330473952 0.0125840363244796 miRNATAP -0.0928670101470823 0.0110956508138902 NA NA NA hsa-miR-301a-3p PIK3CB 1.99338115332667 0.000813358604963724 0.897158330473952 0.0125840363244796 miRNATAP -0.0680972701771611 0.0462034075321984 NA NA NA hsa-miR-7-5p PIK3CB 3.59831747997243 0.000676336260217879 0.897158330473952 0.0125840363244796 miRNAWalker2_validate -0.0616426143592937 0.00884235702490549 NA NA NA hsa-miR-1468-5p PIK3CD -1.63442718498426 0.00779372976116312 0.0551399776366237 0.926564879247674 MirTarget -0.153354934509346 0.00559561965869134 NA NA NA hsa-miR-199a-5p PIK3CD -1.24888110793613 0.0747755616523728 0.0551399776366237 0.926564879247674 MirTarget;PITA;miRanda;miRNATAP -0.160352223725155 0.000860262558034989 NA NA NA hsa-miR-30a-5p PIK3CD -0.768430903969183 0.320487552854215 0.0551399776366237 0.926564879247674 miRNAWalker2_validate;MirTarget;miRNATAP -0.0861493741561497 0.0496328165816106 23486085 miR 30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma; A luciferase reporter assay was performed to determine target association between miR-30a and phosphoinositide 3-kinase catalytic subunit delta PIK3CD miR-30a was significantly downregulated in highly metastatic CRC cell lines and metastatic tissues; Further studies revealed that PIK3CD is a direct target of miR-30a as miR-30a bounds directly to the 3'-UTR of PIK3CD subsequently reducing its expression; Similar to the restoring miR-30a expression PIK3CD downregulation inhibited cell migration and invasion whereas PIK3CD overexpression rescued the suppressive effect of miR-30a; Moreover significant downregulation of miR-30a in metastatic CRC tissues was found to be inversely correlated with PIK3CD expression; Mechanistic studies revealed that miR-30a down-regulated the expression of key components of the Akt/mTOR pathway whereas PIK3CD overexpression reversed this negative effect cell migration colorectal cancer hsa-miR-30d-5p PIK3CD 0.302504510257496 0.380193536606962 0.0551399776366237 0.926564879247674 MirTarget;miRNATAP -0.269704587228763 0.00722775970426478 NA NA NA hsa-miR-324-5p PIK3CD 1.31253452379847 0.0116806680545163 0.0551399776366237 0.926564879247674 miRanda -0.167057802158617 0.010407823026026 NA NA NA hsa-miR-3913-5p PIK3CD 0.145645056779437 0.734844256690741 0.0551399776366237 0.926564879247674 mirMAP -0.258109601835399 0.00117084989668902 NA NA NA hsa-miR-335-3p PIK3CG 1.19503568251824 0.0938852560631551 -0.156343505309127 0.848670326900117 mirMAP -0.289128547018831 6.98940085423769e-06 NA NA NA hsa-miR-502-5p PIK3CG -0.614788359240004 0.318237800399635 -0.156343505309127 0.848670326900117 miRNATAP -0.170404506210511 0.0284752528790852 26163264 Phosphoinositide 3-kinase catalytic subunit gamma PIK3CG was identified as a direct downstream target of miR-502 in HCC cells; Notably overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells liver cancer hsa-miR-1301-3p PIK3R1 2.0309605405243 0.000960892301214288 -1.85375256159008 0.0127438113463991 MirTarget -0.135408648859421 0.0487168326048714 NA NA NA hsa-miR-16-2-3p PIK3R1 3.79845098071094 1.49120139344659e-13 -1.85375256159008 0.0127438113463991 MirTarget -0.220421111740374 0.0054973163518176 NA NA NA hsa-miR-16-5p PIK3R1 2.93575808220754 2.15436817162977e-10 -1.85375256159008 0.0127438113463991 MirTarget -0.232718839097215 0.0094069232214411 NA NA NA hsa-miR-17-5p PIK3R1 2.3269271449522 2.13987445663942e-05 -1.85375256159008 0.0127438113463991 MirTarget;TargetScan;miRNATAP -0.263550021803503 0.000561403048031031 NA NA NA hsa-miR-182-5p PIK3R1 5.86988712704738 1.22411588571584e-15 -1.85375256159008 0.0127438113463991 miRNATAP -0.123631904426682 0.0246928295730376 NA NA NA hsa-miR-200c-3p PIK3R1 6.47012025883743 2.64500707716408e-26 -1.85375256159008 0.0127438113463991 mirMAP -0.209884750055895 0.000971059963262446 NA NA NA hsa-miR-20a-5p PIK3R1 2.13553469875764 0.000181201072324354 -1.85375256159008 0.0127438113463991 MirTarget;miRNATAP -0.16773716444277 0.0232604396745217 NA NA NA hsa-miR-21-5p PIK3R1 2.65163477806992 6.72089787690756e-16 -1.85375256159008 0.0127438113463991 miRNAWalker2_validate;MirTarget;miRNATAP -0.296975751298422 0.0179761051209979 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 2.38337850108621 1.0773503998394e-05 -1.85375256159008 0.0127438113463991 mirMAP -0.166300707017564 0.0322007854872272 NA NA NA hsa-miR-29a-3p PIK3R1 -0.638239697975974 0.251923581881716 -1.85375256159008 0.0127438113463991 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.158482628577245 0.03846338914674 NA NA NA hsa-miR-29b-3p PIK3R1 0.666547117072858 0.234055379278093 -1.85375256159008 0.0127438113463991 MirTarget;miRNATAP -0.229458801110313 0.00247922380727846 NA NA NA hsa-miR-3065-5p PIK3R1 2.14185373842821 0.0609400502269891 -1.85375256159008 0.0127438113463991 MirTarget;mirMAP;miRNATAP -0.136442762182432 0.00300321263691178 NA NA NA hsa-miR-32-3p PIK3R1 2.20477794939766 0.0392771274032852 -1.85375256159008 0.0127438113463991 mirMAP -0.159533357320395 0.0224038643587963 NA NA NA hsa-miR-320b PIK3R1 0.20205459771295 0.727216419960509 -1.85375256159008 0.0127438113463991 miRNATAP -0.176164651324681 0.0166344864485862 NA NA NA hsa-miR-320c PIK3R1 -0.10618808730545 0.854002814666472 -1.85375256159008 0.0127438113463991 miRNATAP -0.237528056213487 0.00153215444016214 NA NA NA hsa-miR-330-3p PIK3R1 2.49094236945806 0.000129367003214715 -1.85375256159008 0.0127438113463991 MirTarget;PITA;miRNATAP -0.222421511130143 0.000560333266659095 NA NA NA hsa-miR-335-3p PIK3R1 1.19503568251824 0.0938852560631551 -1.85375256159008 0.0127438113463991 mirMAP -0.187424798668302 0.00154671007013318 NA NA NA hsa-miR-338-5p PIK3R1 -0.108304629897487 0.894675560494607 -1.85375256159008 0.0127438113463991 PITA -0.149038254580324 0.00415133065382571 NA NA NA hsa-miR-455-3p PIK3R1 2.1864857056272 0.00137304627957677 -1.85375256159008 0.0127438113463991 MirTarget;PITA;miRNATAP -0.154714937051356 0.0121083771583488 NA NA NA hsa-miR-582-5p PIK3R1 0.685177900016753 0.447761540297692 -1.85375256159008 0.0127438113463991 mirMAP -0.168928206892885 0.000293205730117536 NA NA NA hsa-miR-584-5p PIK3R1 1.17912816682866 0.202862496863776 -1.85375256159008 0.0127438113463991 mirMAP -0.264485629334745 3.0909574049315e-09 NA NA NA hsa-miR-590-3p PIK3R1 2.35429565068338 2.79601879608564e-06 -1.85375256159008 0.0127438113463991 miRanda;mirMAP -0.189026585514548 0.0237715511845409 NA NA NA hsa-miR-590-5p PIK3R1 1.51400888103768 0.0023888567923017 -1.85375256159008 0.0127438113463991 MirTarget;PITA;miRanda;miRNATAP -0.297003967343676 0.000452335914243657 NA NA NA hsa-miR-629-3p PIK3R1 3.48282157979573 4.9176538695908e-08 -1.85375256159008 0.0127438113463991 MirTarget -0.21216292379107 0.00105654186835094 NA NA NA hsa-miR-1271-5p PIK3R3 0.212382644103427 0.742544160267329 -0.029728653396571 0.959330193755408 mirMAP -0.151933011438603 0.00299533512999816 NA NA NA hsa-miR-18a-3p PIK3R3 3.64944956993027 7.20156641833731e-07 -0.029728653396571 0.959330193755408 miRNAWalker2_validate -0.172437749406846 8.76134189601592e-05 NA NA NA hsa-miR-19b-3p PIK3R3 1.67581705793313 0.000858910586302716 -0.029728653396571 0.959330193755408 MirTarget;miRNATAP -0.133034812969295 0.0429014365024994 NA NA NA hsa-miR-222-5p PIK3R3 2.52056758362407 0.00142010793166944 -0.029728653396571 0.959330193755408 mirMAP -0.169591357898129 3.80520658072856e-05 NA NA NA hsa-miR-26b-5p PIK3R3 0.314414148564179 0.461628303578321 -0.029728653396571 0.959330193755408 miRNATAP -0.161901214865155 0.0389212618860389 NA NA NA hsa-miR-29b-1-5p PIK3R3 0.33698032160171 0.598092174563471 -0.029728653396571 0.959330193755408 mirMAP -0.214703534793861 3.15537480066889e-05 NA NA NA hsa-miR-32-5p PIK3R3 2.93035124381469 5.00149131394151e-10 -0.029728653396571 0.959330193755408 MirTarget;miRNATAP -0.160755914279694 0.019115600005757 NA NA NA hsa-miR-330-3p PIK3R3 2.49094236945806 0.000129367003214715 -0.029728653396571 0.959330193755408 MirTarget -0.191183653307302 0.000135580399986553 NA NA NA hsa-miR-330-5p PIK3R3 2.25110496739954 0.000275527655397415 -0.029728653396571 0.959330193755408 miRanda -0.158989578902319 0.00262587059425892 NA NA NA hsa-miR-335-3p PIK3R3 1.19503568251824 0.0938852560631551 -0.029728653396571 0.959330193755408 mirMAP -0.103464572034936 0.025428137853466 NA NA NA hsa-miR-365a-3p PIK3R3 0.25545896241765 0.654320504621012 -0.029728653396571 0.959330193755408 MirTarget -0.330277583325266 6.38384266733533e-09 NA NA NA hsa-miR-511-5p PIK3R3 1.10428503984162 0.179276103915417 -0.029728653396571 0.959330193755408 MirTarget -0.179185145111208 6.38466351145281e-06 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-582-5p PIK3R3 0.685177900016753 0.447761540297692 -0.029728653396571 0.959330193755408 PITA -0.0845580674869038 0.0207310156978804 NA NA NA hsa-miR-590-3p PIK3R3 2.35429565068338 2.79601879608564e-06 -0.029728653396571 0.959330193755408 PITA;mirMAP;miRNATAP -0.135597711481687 0.0374254282287608 NA NA NA hsa-miR-590-5p PIK3R3 1.51400888103768 0.0023888567923017 -0.029728653396571 0.959330193755408 miRanda -0.195493025557274 0.00311783468590026 NA NA NA hsa-miR-92a-3p PIK3R3 1.87892405805529 1.27013821556583e-05 -0.029728653396571 0.959330193755408 MirTarget;miRNATAP -0.181892014402978 0.0174346731946844 NA NA NA hsa-miR-125a-3p PIK3R5 -0.0748960586927341 0.920735897434087 0.75811064163987 0.286920846128457 miRanda -0.143772140191083 0.00747323319002246 NA NA NA hsa-miR-125a-5p PIK3R5 -1.32352790615388 0.00714301627309467 0.75811064163987 0.286920846128457 MirTarget;miRanda -0.250957855170204 0.00223286885929377 NA NA NA hsa-miR-182-5p PIK3R5 5.86988712704738 1.22411588571584e-15 0.75811064163987 0.286920846128457 MirTarget -0.25329203027594 9.2894340160784e-07 NA NA NA hsa-let-7g-5p PPP3CA 0.857251702023746 0.00647597344297273 -0.0994691469518081 0.767527156115313 miRNATAP -0.161347150543761 0.00879795113322894 NA NA NA hsa-miR-194-5p PPP3CA 0.691219038144468 0.523143086635506 -0.0994691469518081 0.767527156115313 MirTarget -0.0598915895698759 0.000582475248515281 NA NA NA hsa-miR-340-5p PPP3CA 1.41210478721579 0.00958612942879818 -0.0994691469518081 0.767527156115313 mirMAP -0.0788941179931964 0.0238910354945709 NA NA NA hsa-miR-361-3p PPP3CA 0.805698609170807 0.0418491665498322 -0.0994691469518081 0.767527156115313 MirTarget;PITA;miRNATAP -0.1244680543674 0.0103177804265776 NA NA NA hsa-miR-15b-5p PPP3CB 3.32329949959268 8.40210501034588e-13 -1.40416794438593 1.29693017943289e-07 miRNATAP -0.0725611652243565 0.0230527653374617 NA NA NA hsa-miR-16-5p PPP3CB 2.93575808220754 2.15436817162977e-10 -1.40416794438593 1.29693017943289e-07 miRNATAP -0.0763235806163546 0.0183254889144293 NA NA NA hsa-miR-452-5p PPP3CB 2.45466810475361 0.00114794259949532 -1.40416794438593 1.29693017943289e-07 MirTarget;miRNATAP -0.0741205839878501 0.000207186034451647 NA NA NA hsa-miR-590-3p PPP3CB 2.35429565068338 2.79601879608564e-06 -1.40416794438593 1.29693017943289e-07 miRanda -0.0677807479101551 0.0246139895731794 NA NA NA hsa-miR-26a-5p PPP3R1 -0.352368463397074 0.362040749917446 0.0168260760846062 0.942837288910097 MirTarget;miRNATAP -0.0832850830617438 0.0160228728403177 NA NA NA hsa-miR-30a-5p PPP3R1 -0.768430903969183 0.320487552854215 0.0168260760846062 0.942837288910097 miRNAWalker2_validate;MirTarget;miRNATAP -0.0724239274865126 1.67791795349007e-05 NA NA NA hsa-miR-196b-5p PRKACA -0.103579538052452 0.859017000109845 -0.341906193120061 0.197523491461236 miRNAWalker2_validate -0.0836013952835858 0.0011061808926737 NA NA NA hsa-miR-2110 PRKACA 1.8070969695103 0.00137196847440523 -0.341906193120061 0.197523491461236 MirTarget -0.0610804195504686 0.0234667590789892 NA NA NA hsa-miR-331-3p PRKACA 2.60769294751513 3.84318952029483e-07 -0.341906193120061 0.197523491461236 miRNAWalker2_validate -0.0758573833354115 0.00811186808921016 NA NA NA hsa-miR-374b-3p PRKACA 0.501845732983925 0.343338908602826 -0.341906193120061 0.197523491461236 mirMAP -0.0973910522387042 0.000637262722280453 NA NA NA hsa-miR-491-5p PRKACA 0.569358547192776 0.313310594748302 -0.341906193120061 0.197523491461236 MirTarget;miRanda -0.082159713109076 0.00224888164417822 NA NA NA hsa-miR-590-3p PRKACA 2.35429565068338 2.79601879608564e-06 -0.341906193120061 0.197523491461236 miRanda -0.0848432694030459 0.00386248223624502 NA NA NA hsa-miR-625-5p PRKACA 2.02792641909347 0.000935142379948297 -0.341906193120061 0.197523491461236 MirTarget -0.0683083571400496 0.00512615132692787 NA NA NA hsa-miR-744-5p PRKACA 1.03691757606528 0.0434004722240021 -0.341906193120061 0.197523491461236 miRNAWalker2_validate -0.0812442803069534 0.00533934315380773 NA NA NA hsa-miR-96-5p PRKACA 5.62521466029286 1.54938806718028e-10 -0.341906193120061 0.197523491461236 TargetScan -0.0699962524663693 0.000484914072336726 NA NA NA hsa-let-7a-3p PRKACB 0.82512001802525 0.0468122405194487 -1.46896806095161 0.00691161548744777 MirTarget;mirMAP;miRNATAP -0.212227756129949 0.00484060334729975 NA NA NA hsa-let-7f-1-3p PRKACB 1.61507869803314 0.00069342464777815 -1.46896806095161 0.00691161548744777 MirTarget;mirMAP -0.153633672665785 0.0188406734868941 NA NA NA hsa-miR-141-3p PRKACB 7.30474126597325 1.45115996357606e-24 -1.46896806095161 0.00691161548744777 MirTarget;TargetScan;miRNATAP -0.179713976485568 5.50509722074074e-06 NA NA NA hsa-miR-16-2-3p PRKACB 3.79845098071094 1.49120139344659e-13 -1.46896806095161 0.00691161548744777 mirMAP -0.256987391063205 7.64721558586313e-06 NA NA NA hsa-miR-17-5p PRKACB 2.3269271449522 2.13987445663942e-05 -1.46896806095161 0.00691161548744777 TargetScan -0.147030961972885 0.00870649595844882 NA NA NA hsa-miR-182-5p PRKACB 5.86988712704738 1.22411588571584e-15 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.137741652786639 0.000572629355125557 NA NA NA hsa-miR-183-5p PRKACB 6.61903249270777 1.00958881445636e-16 -1.46896806095161 0.00691161548744777 MirTarget -0.125680903296988 0.000602029705127091 NA NA NA hsa-miR-18a-5p PRKACB 3.90770175770219 9.15298615034137e-10 -1.46896806095161 0.00691161548744777 miRNATAP -0.147626596716624 0.00172397395444837 NA NA NA hsa-miR-193a-3p PRKACB 0.646392169474854 0.207134343676122 -1.46896806095161 0.00691161548744777 miRanda -0.257394862253127 1.9252355211219e-05 NA NA NA hsa-miR-19a-3p PRKACB 2.17020503944519 0.00122084653711062 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.131490327577289 0.0040920531186784 NA NA NA hsa-miR-19b-3p PRKACB 1.67581705793313 0.000858910586302716 -1.46896806095161 0.00691161548744777 miRNAWalker2_validate;MirTarget;miRNATAP -0.191193316637283 0.00183404785527112 NA NA NA hsa-miR-200a-3p PRKACB 6.336081120041 4.024313571871e-16 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.104144124001908 0.00576356163422443 NA NA NA hsa-miR-200b-3p PRKACB 5.56167217794639 6.43540045061709e-16 -1.46896806095161 0.00691161548744777 MirTarget;TargetScan -0.0904796165905836 0.034808578931053 NA NA NA hsa-miR-200c-3p PRKACB 6.47012025883743 2.64500707716408e-26 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.145130591541329 0.00181365494045828 NA NA NA hsa-miR-2110 PRKACB 1.8070969695103 0.00137196847440523 -1.46896806095161 0.00691161548744777 MirTarget -0.110796601580735 0.0478171002562626 NA NA NA hsa-miR-3065-5p PRKACB 2.14185373842821 0.0609400502269891 -1.46896806095161 0.00691161548744777 MirTarget -0.128827162641901 0.000116356569225078 NA NA NA hsa-miR-30d-3p PRKACB -0.0740421896025512 0.857423650167556 -1.46896806095161 0.00691161548744777 mirMAP -0.149931488326972 0.0496499969555609 NA NA NA hsa-miR-362-3p PRKACB 0.679952485897744 0.226148468488576 -1.46896806095161 0.00691161548744777 PITA;miRanda;miRNATAP -0.132462710993008 0.0171492521812846 NA NA NA hsa-miR-3653-3p PRKACB 2.32416512605984 0.000268136992079666 -1.46896806095161 0.00691161548744777 MirTarget -0.101834528600714 0.0351697054212881 NA NA NA hsa-miR-429 PRKACB 6.39965293994036 1.96920201593608e-18 -1.46896806095161 0.00691161548744777 MirTarget;PITA;miRanda;miRNATAP -0.108770954611392 0.00641118010678973 NA NA NA hsa-miR-590-3p PRKACB 2.35429565068338 2.79601879608564e-06 -1.46896806095161 0.00691161548744777 MirTarget;PITA;miRanda;miRNATAP -0.150489017415495 0.0136835439007164 NA NA NA hsa-miR-590-5p PRKACB 1.51400888103768 0.0023888567923017 -1.46896806095161 0.00691161548744777 miRanda -0.159509934061525 0.0102765865766552 NA NA NA hsa-miR-93-5p PRKACB 2.65964181833033 2.58315947526774e-08 -1.46896806095161 0.00691161548744777 miRNAWalker2_validate -0.1828758599464 0.00409856289818273 NA NA NA hsa-miR-96-5p PRKACB 5.62521466029286 1.54938806718028e-10 -1.46896806095161 0.00691161548744777 miRNATAP -0.17033105097326 3.99524226143001e-05 NA NA NA hsa-miR-141-3p PRKAR1A 7.30474126597325 1.45115996357606e-24 -1.01828820623811 0.001225821997322 TargetScan -0.0906436097873937 7.83225136945999e-05 NA NA NA hsa-miR-155-5p PRKAR1A 2.81443182173772 7.42530504828797e-05 -1.01828820623811 0.001225821997322 miRNAWalker2_validate -0.0759764291550117 0.00224535100146211 NA NA NA hsa-miR-16-2-3p PRKAR1A 3.79845098071094 1.49120139344659e-13 -1.01828820623811 0.001225821997322 mirMAP -0.097700070860167 0.0035464770843231 NA NA NA hsa-miR-182-5p PRKAR1A 5.86988712704738 1.22411588571584e-15 -1.01828820623811 0.001225821997322 miRNATAP -0.0615139167768874 0.00803191079119212 NA NA NA hsa-miR-186-5p PRKAR1A 0.445443449112564 0.185447310527704 -1.01828820623811 0.001225821997322 mirMAP -0.180144708459278 0.000892993033458124 NA NA NA hsa-miR-200b-3p PRKAR1A 5.56167217794639 6.43540045061709e-16 -1.01828820623811 0.001225821997322 TargetScan -0.0701447945811913 0.00452365098242001 NA NA NA hsa-miR-25-3p PRKAR1A 1.12623030168869 0.00311079344417173 -1.01828820623811 0.001225821997322 miRNAWalker2_validate -0.137457165995076 0.00373320016478192 NA NA NA hsa-miR-30e-5p PRKAR1A 0.780047227271616 0.0346714425913016 -1.01828820623811 0.001225821997322 mirMAP -0.195080535639843 6.48511031213636e-05 NA NA NA hsa-miR-32-3p PRKAR1A 2.20477794939766 0.0392771274032852 -1.01828820623811 0.001225821997322 mirMAP -0.0847298143773523 0.00398948592479647 NA NA NA hsa-miR-342-3p PRKAR1A 1.31107714473009 0.0207211910724662 -1.01828820623811 0.001225821997322 miRanda -0.0735837097638897 0.0200110006364583 NA NA NA hsa-miR-429 PRKAR1A 6.39965293994036 1.96920201593608e-18 -1.01828820623811 0.001225821997322 PITA;miRanda;miRNATAP -0.0765236824054684 0.00087539598030048 NA NA NA hsa-miR-590-3p PRKAR1A 2.35429565068338 2.79601879608564e-06 -1.01828820623811 0.001225821997322 miRanda;mirMAP -0.117659255376238 0.000811435622796728 NA NA NA hsa-miR-590-5p PRKAR1A 1.51400888103768 0.0023888567923017 -1.01828820623811 0.001225821997322 miRanda -0.10914100263527 0.00232969513055624 NA NA NA hsa-miR-96-5p PRKAR1A 5.62521466029286 1.54938806718028e-10 -1.01828820623811 0.001225821997322 miRNAWalker2_validate;TargetScan;miRNATAP -0.0721623908512636 0.002775449839273 NA NA NA hsa-let-7a-3p PRKAR2A 0.82512001802525 0.0468122405194487 0.476694411438259 0.551908785996894 mirMAP -0.301009578826657 0.00647099970354146 NA NA NA hsa-let-7f-1-3p PRKAR2A 1.61507869803314 0.00069342464777815 0.476694411438259 0.551908785996894 mirMAP -0.216904265787296 0.023842927545171 NA NA NA hsa-miR-125a-5p PRKAR2A -1.32352790615388 0.00714301627309467 0.476694411438259 0.551908785996894 miRanda -0.269844648912326 0.00350273799952414 NA NA NA hsa-miR-155-5p PRKAR2A 2.81443182173772 7.42530504828797e-05 0.476694411438259 0.551908785996894 miRNAWalker2_validate -0.21708406345224 0.000566306153716087 NA NA NA hsa-miR-26a-5p PRKAR2A -0.352368463397074 0.362040749917446 0.476694411438259 0.551908785996894 mirMAP -0.334762860834375 0.00501415610057783 NA NA NA hsa-miR-26b-5p PRKAR2A 0.314414148564179 0.461628303578321 0.476694411438259 0.551908785996894 mirMAP -0.286017162331329 0.00788651739787191 NA NA NA hsa-miR-28-5p PRKAR2A -0.815636722979196 0.0221199948901761 0.476694411438259 0.551908785996894 miRanda -0.282863710025104 0.0292450508726876 NA NA NA hsa-miR-29a-5p PRKAR2A 0.0748295222568571 0.884125894063293 0.476694411438259 0.551908785996894 mirMAP -0.315640015483038 0.000372346869393992 NA NA NA hsa-miR-320a PRKAR2A -0.912036444869976 0.0565555443926988 0.476694411438259 0.551908785996894 mirMAP -0.268019149243362 0.00499308515469227 NA NA NA hsa-miR-320b PRKAR2A 0.20205459771295 0.727216419960509 0.476694411438259 0.551908785996894 mirMAP -0.160674727798191 0.0418289894929402 NA NA NA hsa-miR-335-5p PRKAR2A 0.167216045757305 0.803897055331049 0.476694411438259 0.551908785996894 mirMAP -0.141560345781286 0.0366018295244779 NA NA NA hsa-miR-342-5p PRKAR2A 1.3865615438184 0.0153598969109545 0.476694411438259 0.551908785996894 miRNATAP -0.269573945336104 0.000654404755458937 NA NA NA hsa-miR-3607-3p PRKAR2A 1.38015131722213 0.0240067155694847 0.476694411438259 0.551908785996894 mirMAP -0.244787916293228 0.000939419376053357 NA NA NA hsa-miR-3913-5p PRKAR2A 0.145645056779437 0.734844256690741 0.476694411438259 0.551908785996894 mirMAP -0.246421830440637 0.0213785759516597 NA NA NA hsa-miR-708-3p PRKAR2A 0.781444321399141 0.290645825716608 0.476694411438259 0.551908785996894 mirMAP -0.152913264224168 0.0128401604293749 NA NA NA hsa-let-7a-3p PRKAR2B 0.82512001802525 0.0468122405194487 -2.78794723692538 0.0026756054188432 mirMAP -0.490436382372777 0.000131692115153379 NA NA NA hsa-let-7f-1-3p PRKAR2B 1.61507869803314 0.00069342464777815 -2.78794723692538 0.0026756054188432 mirMAP -0.590656604378212 7.69012984955533e-08 NA NA NA hsa-miR-200c-3p PRKAR2B 6.47012025883743 2.64500707716408e-26 -2.78794723692538 0.0026756054188432 miRNATAP -0.232410940316261 0.00356398855766406 NA NA NA hsa-miR-32-5p PRKAR2B 2.93035124381469 5.00149131394151e-10 -2.78794723692538 0.0026756054188432 miRNATAP -0.359735337701038 0.00104357271928938 NA NA NA hsa-miR-335-3p PRKAR2B 1.19503568251824 0.0938852560631551 -2.78794723692538 0.0026756054188432 mirMAP -0.188812955591594 0.0110198275001046 NA NA NA hsa-miR-429 PRKAR2B 6.39965293994036 1.96920201593608e-18 -2.78794723692538 0.0026756054188432 PITA;miRanda;miRNATAP -0.136030845210326 0.0470940607906142 NA NA NA hsa-miR-590-3p PRKAR2B 2.35429565068338 2.79601879608564e-06 -2.78794723692538 0.0026756054188432 miRNAWalker2_validate;miRanda -0.336156932957071 0.00124725671489497 NA NA NA hsa-miR-92a-3p PRKAR2B 1.87892405805529 1.27013821556583e-05 -2.78794723692538 0.0026756054188432 miRNATAP -0.399693388608365 0.00109215156585527 NA NA NA hsa-miR-944 PRKAR2B 7.20925181386398 0.000823207457340648 -2.78794723692538 0.0026756054188432 mirMAP -0.153211582863098 2.7267140771681e-07 NA NA NA hsa-miR-129-5p PRKX -2.66843722411409 0.00695783358331245 2.17507999383594 0.000704686070863552 miRanda;mirMAP -0.0781273443324246 0.0373501510895213 NA NA NA hsa-miR-130a-5p PRKX 1.58028512890005 0.024346333013728 2.17507999383594 0.000704686070863552 mirMAP -0.187730727746443 0.00038419514315305 NA NA NA hsa-miR-148b-3p PRKX 1.75622244535669 8.84414356040579e-08 2.17507999383594 0.000704686070863552 MirTarget -0.306982570800927 0.00606517379097925 NA NA NA hsa-miR-181b-5p PRKX 1.11397227523501 0.0273417050354018 2.17507999383594 0.000704686070863552 mirMAP -0.171922484715549 0.0185944166277157 NA NA NA hsa-miR-29b-3p PRKX 0.666547117072858 0.234055379278093 2.17507999383594 0.000704686070863552 mirMAP -0.164536960121623 0.0124366136750478 NA NA NA hsa-miR-335-3p PRKX 1.19503568251824 0.0938852560631551 2.17507999383594 0.000704686070863552 mirMAP -0.162862473837577 0.00148982890472507 NA NA NA hsa-miR-375 PRKX 3.3784490463318 0.0449946294355695 2.17507999383594 0.000704686070863552 miRNAWalker2_validate;miRanda -0.0952883183179076 8.48014493788258e-06 NA NA NA hsa-miR-421 RELA 1.97624148591545 0.000915838012451138 -0.603090858846882 0.00458348622633853 miRanda -0.0593312158374071 0.00301815803231147 NA NA NA hsa-miR-769-5p RELA 0.41777775802937 0.343089124193569 -0.603090858846882 0.00458348622633853 miRNATAP -0.0919525730213121 0.000772774085194781 NA NA NA hsa-miR-361-5p TNF 0.00649167180664723 0.985202350239079 2.70587865709665 0.00827809785812044 miRanda -0.699393715835311 3.55980064084335e-05 NA NA NA hsa-miR-429 TNF 6.39965293994036 1.96920201593608e-18 2.70587865709665 0.00827809785812044 miRNATAP -0.166672367413636 0.0271661300621378 NA NA NA hsa-miR-654-3p TNF -1.00320329950348 0.243908885746048 2.70587865709665 0.00827809785812044 miRNATAP -0.184952039903252 0.006307888857058 NA NA NA hsa-miR-28-5p TNFRSF10B -0.815636722979196 0.0221199948901761 1.49454504792051 0.00242678998916782 miRanda -0.176105256176701 0.0281698781078749 NA NA NA hsa-miR-340-5p TNFRSF10B 1.41210478721579 0.00958612942879818 1.49454504792051 0.00242678998916782 miRNAWalker2_validate -0.149759402379779 0.00368309518497458 NA NA NA hsa-miR-26a-5p TNFRSF10D -0.352368463397074 0.362040749917446 -1.21291781589212 0.12813188438224 mirMAP -0.443727421653665 0.000175681471900891 NA NA NA hsa-miR-590-3p TNFRSF10D 2.35429565068338 2.79601879608564e-06 -1.21291781589212 0.12813188438224 miRanda -0.213832330292469 0.0165761405332802 NA NA NA hsa-miR-7-1-3p TNFRSF10D 1.43074343339835 0.00471215970502094 -1.21291781589212 0.12813188438224 mirMAP -0.202460494552346 0.0238821195932147 NA NA NA hsa-miR-766-3p TNFRSF1A 2.6460519504539 8.60200045402435e-06 -0.659377512671059 0.0889418349306143 MirTarget -0.100128221820332 0.00599976091689645 NA NA NA hsa-miR-129-5p TNFSF10 -2.66843722411409 0.00695783358331245 2.118758562145 0.0216437100588859 miRanda -0.207618069660698 9.59656903576055e-05 NA NA NA hsa-miR-217 TNFSF10 -0.378397407994341 0.717408682071252 2.118758562145 0.0216437100588859 miRanda -0.202017009365184 5.47278192731572e-05 NA NA NA hsa-miR-361-5p TNFSF10 0.00649167180664723 0.985202350239079 2.118758562145 0.0216437100588859 miRanda -0.417422213365056 0.00645858491593377 NA NA NA hsa-miR-324-3p TRADD 1.51345381556672 0.0038447546677657 1.087891208472 0.00809576832135138 miRNATAP -0.163418626847223 0.000228267741497048 NA NA NA hsa-miR-140-3p TRAF2 -1.9828800596692 8.92876132959514e-08 1.35582024883595 0.000560852550980972 MirTarget -0.118674027002529 0.0489723600787535 NA NA NA hsa-miR-214-5p TRAF2 -0.774687536083087 0.261144553129847 1.35582024883595 0.000560852550980972 MirTarget -0.0987985967791724 0.00234447697963679 NA NA NA hsa-miR-106b-5p XIAP 2.80565545918114 1.14547999022566e-09 0.21193990907902 0.492489660258725 miRNATAP -0.0995806674201465 0.00709858108665541 NA NA NA hsa-miR-130a-5p XIAP 1.58028512890005 0.024346333013728 0.21193990907902 0.492489660258725 MirTarget;miRNATAP -0.0666512061344386 0.00811083388838806 24145606 Downregulation of miR 130a contributes to cisplatin resistance in ovarian cancer cells by targeting X linked inhibitor of apoptosis XIAP directly; Furthermore we found that miR-130a can directly target XIAP and participate in the regulation of apoptosis; The up-regulation of miR-130a led to a significant decrease in the XIAP mRNA levels and protein levels; Our findings suggested that miR-130a could play a role in the development of cisplatin resistance in ovarian cancer cell line A2780 at least in part by modulation of apoptosis via targeting XIAP drug resistance ovarian cancer hsa-miR-149-5p XIAP 1.18551753240939 0.197439607622379 0.21193990907902 0.492489660258725 MirTarget -0.0703512433397489 0.000176382526798372 NA NA NA hsa-miR-17-5p XIAP 2.3269271449522 2.13987445663942e-05 0.21193990907902 0.492489660258725 miRNAWalker2_validate;TargetScan -0.115272263388315 0.000232899306031091 NA NA NA hsa-miR-181a-2-3p XIAP 0.892907671722579 0.191670574975465 0.21193990907902 0.492489660258725 mirMAP -0.0951862374538302 0.000168604539908062 NA NA NA hsa-miR-181b-5p XIAP 1.11397227523501 0.0273417050354018 0.21193990907902 0.492489660258725 miRNAWalker2_validate;miRTarBase;mirMAP -0.087673880300153 0.0112812644082365 NA NA NA hsa-miR-19a-3p XIAP 2.17020503944519 0.00122084653711062 0.21193990907902 0.492489660258725 mirMAP -0.0653970488037664 0.0111610968649351 NA NA NA hsa-miR-19b-1-5p XIAP 1.51335451095424 0.0014717605268143 0.21193990907902 0.492489660258725 MirTarget -0.130591301091723 0.000335776643741966 NA NA NA hsa-miR-19b-3p XIAP 1.67581705793313 0.000858910586302716 0.21193990907902 0.492489660258725 mirMAP -0.100699249525642 0.00352329780167423 NA NA NA hsa-miR-20a-5p XIAP 2.13553469875764 0.000181201072324354 0.21193990907902 0.492489660258725 miRNATAP -0.0986460648336478 0.00109311292455779 NA NA NA hsa-miR-2355-3p XIAP 0.494099635633886 0.483724014019781 0.21193990907902 0.492489660258725 MirTarget;miRNATAP -0.0628043402288717 0.0111122051197633 NA NA NA hsa-miR-25-3p XIAP 1.12623030168869 0.00311079344417173 0.21193990907902 0.492489660258725 mirMAP -0.166772933993496 0.000279588647819815 NA NA NA hsa-miR-27a-3p XIAP 1.76094007417453 0.000216137556256765 0.21193990907902 0.492489660258725 miRNATAP -0.0866333972699042 0.0176604070391993 26662313 miR 27a regulates the sensitivity of breast cancer cells to cisplatin treatment via BAK SMAC/DIABLO XIAP axis; After further investigation we indicated that the knockdown of miR-27a promoted the apoptosis via mitochondrial pathway in T-47D cells treated with CDDP depending on the BAK-second mitochondria-derived activator of caspase/direct IAP binding protein with low pI SMAC/DIABLO-X-linked inhibitor of apoptosis XIAP axis breast cancer hsa-miR-32-3p XIAP 2.20477794939766 0.0392771274032852 0.21193990907902 0.492489660258725 mirMAP -0.100227774344178 0.000439730838218322 NA NA NA hsa-miR-32-5p XIAP 2.93035124381469 5.00149131394151e-10 0.21193990907902 0.492489660258725 mirMAP -0.0840714457008389 0.0200846673707907 NA NA NA hsa-miR-320a XIAP -0.912036444869976 0.0565555443926988 0.21193990907902 0.492489660258725 MirTarget;miRanda;miRNATAP -0.0730965096464983 0.046289699015276 NA NA NA hsa-miR-320b XIAP 0.20205459771295 0.727216419960509 0.21193990907902 0.492489660258725 MirTarget;miRanda;miRNATAP -0.059902894196492 0.0476249638304475 NA NA NA hsa-miR-335-3p XIAP 1.19503568251824 0.0938852560631551 0.21193990907902 0.492489660258725 mirMAP -0.090950924863697 0.000173548943994221 NA NA NA hsa-miR-33a-3p XIAP 2.06269680799532 0.00156436055383943 0.21193990907902 0.492489660258725 mirMAP -0.0662749527392505 0.0129576749077972 NA NA NA hsa-miR-484 XIAP 1.79050445056016 0.000217287101253701 0.21193990907902 0.492489660258725 mirMAP -0.105802985633609 0.00311442744504824 NA NA NA hsa-miR-589-3p XIAP 1.33205316880069 0.052632683806148 0.21193990907902 0.492489660258725 MirTarget -0.0772892196925229 0.00233998822880526 NA NA NA hsa-miR-590-3p XIAP 2.35429565068338 2.79601879608564e-06 0.21193990907902 0.492489660258725 MirTarget;miRanda;mirMAP -0.0972680321933287 0.00450057810241255 NA NA NA hsa-miR-7-1-3p XIAP 1.43074343339835 0.00471215970502094 0.21193990907902 0.492489660258725 mirMAP -0.0984762327187459 0.00415986575579746 NA NA NA hsa-miR-7-5p XIAP 3.59831747997243 0.000676336260217879 0.21193990907902 0.492489660258725 miRNATAP -0.0742191860818945 0.000202759577141128 23742934 Furthermore an oncogene X-linked inhibitor of apoptosis protein XIAP was identified as a new target of miR-7 and the ectopic expression of XIAP rescued the effects induced by miR-7 in HeLa and C-33A cells; These results indicate that miR-7 targeted and downregulated the oncogene XIAP to regulate the effect of miR-7 on apoptosis and malignant behaviors of HeLa and C-33A cells malignant trasformation cervical and endocervical cancer hsa-miR-766-3p XIAP 2.6460519504539 8.60200045402435e-06 0.21193990907902 0.492489660258725 mirMAP -0.0679207839812153 0.0189304924710194 NA NA NA hsa-miR-92a-3p XIAP 1.87892405805529 1.27013821556583e-05 0.21193990907902 0.492489660258725 mirMAP -0.136415865455041 0.000676507864354257 NA NA NA hsa-miR-92b-3p XIAP 1.69303761469782 0.0103484911955574 0.21193990907902 0.492489660258725 mirMAP -0.0670245180981161 0.0107523078324346 NA NA NA hsa-miR-940 XIAP 3.78496690968119 4.75227557809023e-05 0.21193990907902 0.492489660258725 miRNATAP -0.0638594152888516 0.00469309896562443 NA NA NA