miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-5p ABL1 -0.228773940533783 0.938952933213741 0.0158807082871171 0.992097260118397 miRNAWalker2_validate -0.103500743977103 0.0037190649676014 NA NA NA hsa-miR-128-3p ABL1 -0.442192625156042 0.783886533572187 0.0158807082871171 0.992097260118397 MirTarget -0.115184308733698 0.000418213827549692 NA NA NA hsa-let-7d-5p ABL2 -0.139747701175051 0.934164162708487 0.25748028918974 0.814757215888686 miRNATAP -0.167702642416942 0.00192936702568073 NA NA NA hsa-let-7g-5p ABL2 -0.200947212961157 0.922992045181955 0.25748028918974 0.814757215888686 miRNATAP -0.177937398931533 0.000658686445723566 NA NA NA hsa-miR-106b-5p ABL2 -0.297128724729339 0.869294443540749 0.25748028918974 0.814757215888686 MirTarget -0.154570712747694 4.67677929987141e-05 NA NA NA hsa-miR-107 ABL2 -0.0365118169251648 0.988364120226869 0.25748028918974 0.814757215888686 MirTarget;PITA;miRanda;miRNATAP -0.153155684102508 0.00649988132132128 NA NA NA hsa-miR-1266-5p ABL2 -0.749998297098308 0.475802062565143 0.25748028918974 0.814757215888686 MirTarget -0.125061909076634 1.23125242027693e-07 NA NA NA hsa-miR-128-3p ABL2 -0.442192625156042 0.783886533572187 0.25748028918974 0.814757215888686 MirTarget -0.196292779877689 3.61013508564032e-06 NA NA NA hsa-miR-141-3p ABL2 -0.31994058840327 0.87774106909065 0.25748028918974 0.814757215888686 MirTarget;TargetScan;miRNATAP -0.13122525648346 2.52953268349988e-06 NA NA NA hsa-miR-141-5p ABL2 -0.354590233549885 0.867642456336402 0.25748028918974 0.814757215888686 MirTarget;miRNATAP -0.153372216320578 2.3665757315964e-07 NA NA NA hsa-miR-146a-5p ABL2 -0.581292803346906 0.73685134936757 0.25748028918974 0.814757215888686 MirTarget;mirMAP -0.125325644271109 6.38462317270578e-06 NA NA NA hsa-miR-148a-5p ABL2 -0.448099743845604 0.748419139652266 0.25748028918974 0.814757215888686 miRNATAP -0.149980559798121 4.23288190923094e-06 NA NA NA hsa-miR-155-5p ABL2 -0.407235807706004 0.828669616718496 0.25748028918974 0.814757215888686 mirMAP -0.110594255322178 0.00073993944049787 NA NA NA hsa-miR-15a-5p ABL2 -0.0674049094129128 0.964835434214123 0.25748028918974 0.814757215888686 MirTarget;miRNATAP -0.161217451079176 5.18225558331011e-05 NA NA NA hsa-miR-15b-3p ABL2 -0.557749208157585 0.609181305423188 0.25748028918974 0.814757215888686 mirMAP -0.140105667806551 3.77741351618904e-05 NA NA NA hsa-miR-15b-5p ABL2 -0.272614787130877 0.87096541832188 0.25748028918974 0.814757215888686 MirTarget;miRNATAP -0.12477120544515 0.000911646083267461 NA NA NA hsa-miR-16-5p ABL2 0.0135949734723564 0.994476223855607 0.25748028918974 0.814757215888686 miRNAWalker2_validate;MirTarget;miRNATAP -0.134062419134387 0.000341853395152909 NA NA NA hsa-miR-186-5p ABL2 -0.318786974828757 0.85412722938961 0.25748028918974 0.814757215888686 MirTarget;mirMAP -0.209311183911321 5.9437818572964e-06 NA NA NA hsa-miR-200a-3p ABL2 -0.367034437440907 0.851059894150266 0.25748028918974 0.814757215888686 MirTarget;miRNATAP -0.131355489365334 1.26916728705263e-06 NA NA NA hsa-miR-200a-5p ABL2 -0.671005453811576 0.78126028567661 0.25748028918974 0.814757215888686 mirMAP -0.19351434566663 4.89556345372729e-11 NA NA NA hsa-miR-200b-3p ABL2 -0.426401948379212 0.863957108574195 0.25748028918974 0.814757215888686 MirTarget -0.152243086626758 2.02810428984145e-06 NA NA NA hsa-miR-200b-5p ABL2 -0.502275384207405 0.722255155236927 0.25748028918974 0.814757215888686 mirMAP -0.163489714037656 3.0902762802374e-08 NA NA NA hsa-miR-200c-3p ABL2 -0.437282635857873 0.887118598436407 0.25748028918974 0.814757215888686 MirTarget -0.131712389235657 7.40185422333322e-05 NA NA NA hsa-miR-26a-1-3p ABL2 -0.429875601809349 0.182136384322617 0.25748028918974 0.814757215888686 MirTarget;mirMAP -0.112991172129671 6.88151657878004e-05 NA NA NA hsa-miR-26b-5p ABL2 -0.0245931278499594 0.990377966314923 0.25748028918974 0.814757215888686 MirTarget;miRNATAP -0.145714080926638 0.0010578768079615 NA NA NA hsa-miR-324-5p ABL2 -0.50063248413014 0.537416710557032 0.25748028918974 0.814757215888686 miRNATAP -0.111412682952756 0.00149983480530691 NA NA NA hsa-miR-378a-3p ABL2 -0.466787210598086 0.795055970353024 0.25748028918974 0.814757215888686 mirMAP -0.145039030673044 7.63424693013729e-05 NA NA NA hsa-miR-429 ABL2 -0.456485631615963 0.806240953400535 0.25748028918974 0.814757215888686 MirTarget -0.124235762208473 1.68678807524084e-06 NA NA NA hsa-miR-505-3p ABL2 -0.469094267152605 0.690382680489578 0.25748028918974 0.814757215888686 miRNATAP -0.10457290959031 0.00933809430333902 NA NA NA hsa-miR-576-5p ABL2 -0.506413219377403 0.417187951364173 0.25748028918974 0.814757215888686 mirMAP -0.15435794590189 2.73602495366854e-06 NA NA NA hsa-miR-582-3p ABL2 -0.2334649592375 0.897678119160318 0.25748028918974 0.814757215888686 PITA -0.155108814462147 6.69682013933829e-06 NA NA NA hsa-miR-589-5p ABL2 -0.448771545046784 0.722725226273464 0.25748028918974 0.814757215888686 MirTarget;miRNATAP -0.163075058305829 0.000352726162406142 NA NA NA hsa-miR-590-3p ABL2 -0.279244755376859 0.59126669933662 0.25748028918974 0.814757215888686 PITA;mirMAP;miRNATAP -0.131119563512785 1.6988286673164e-06 NA NA NA hsa-miR-625-3p ABL2 -0.977871291091597 0.62432866948939 0.25748028918974 0.814757215888686 mirMAP -0.149401467336078 3.67019500167958e-10 NA NA NA hsa-miR-7-1-3p ABL2 -0.462485777435991 0.665899751398166 0.25748028918974 0.814757215888686 mirMAP -0.131082534801175 5.0378540878155e-05 NA NA NA hsa-miR-744-3p ABL2 -0.540090234027722 0.490553451682436 0.25748028918974 0.814757215888686 mirMAP -0.110109967935817 0.000245637857158223 NA NA NA hsa-miR-93-5p ABL2 -0.611073677204699 0.825297877093193 0.25748028918974 0.814757215888686 MirTarget -0.150352573063016 2.72355248083735e-05 NA NA NA hsa-miR-106a-5p AKT3 -0.203919267842652 0.802213958426804 0.457269233600447 0.539326812115034 miRNATAP -0.549479065869633 4.88994896864722e-11 NA NA NA hsa-miR-106b-5p AKT3 -0.297128724729339 0.869294443540749 0.457269233600447 0.539326812115034 miRNATAP -0.910251258276316 1.51432008761514e-23 NA NA NA hsa-miR-107 AKT3 -0.0365118169251648 0.988364120226869 0.457269233600447 0.539326812115034 PITA;miRanda -0.551086378595188 0.000172037624489873 NA NA NA hsa-miR-1275 AKT3 -0.831342050607648 0.0803795852164229 0.457269233600447 0.539326812115034 PITA -0.265795172887599 9.47325565176386e-07 NA NA NA hsa-miR-142-3p AKT3 -0.154235241441331 0.946098054588918 0.457269233600447 0.539326812115034 miRanda -0.196043223886578 0.00627089530211866 NA NA NA hsa-miR-15a-5p AKT3 -0.0674049094129128 0.964835434214123 0.457269233600447 0.539326812115034 miRNAWalker2_validate;miRTarBase;miRNATAP -0.721206491484116 7.61586942839311e-13 NA NA NA hsa-miR-15b-5p AKT3 -0.272614787130877 0.87096541832188 0.457269233600447 0.539326812115034 miRNATAP -0.665977383717092 1.97063059627596e-12 NA NA NA hsa-miR-16-5p AKT3 0.0135949734723564 0.994476223855607 0.457269233600447 0.539326812115034 miRNAWalker2_validate;miRTarBase;miRNATAP -0.746124766270904 9.10401236853758e-16 NA NA NA hsa-miR-17-3p AKT3 0.100221625453134 0.960113387014848 0.457269233600447 0.539326812115034 miRNATAP -0.519758313376015 2.03997342351785e-09 NA NA NA hsa-miR-17-5p AKT3 -0.175448849583061 0.934544015912731 0.457269233600447 0.539326812115034 TargetScan;miRNATAP -0.626536048377156 1.11076874125702e-18 NA NA NA hsa-miR-181b-5p AKT3 0.155313039554487 0.930176779696506 0.457269233600447 0.539326812115034 miRNATAP -0.268064668813324 0.00963449049657038 NA NA NA hsa-miR-20a-5p AKT3 -0.179153323927949 0.928118119139752 0.457269233600447 0.539326812115034 miRNATAP -0.531063551395964 1.32783278364081e-13 NA NA NA hsa-miR-28-3p AKT3 -0.227916837431808 0.935350995840384 0.457269233600447 0.539326812115034 miRNATAP -0.521845591393563 0.00718630427898147 NA NA NA hsa-miR-29a-3p AKT3 0.01127474410284 0.996977020481272 0.457269233600447 0.539326812115034 miRNATAP -0.812359982380835 1.03842433672581e-13 NA NA NA hsa-miR-29b-3p AKT3 -0.104016192263954 0.958988036765397 0.457269233600447 0.539326812115034 miRNATAP -0.677276652111253 9.58518141369729e-17 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-32-3p AKT3 -0.568003960723004 0.13133163420273 0.457269233600447 0.539326812115034 mirMAP -0.563455040593992 1.29815959529041e-22 NA NA NA hsa-miR-320a AKT3 -0.416546433767628 0.840202138616422 0.457269233600447 0.539326812115034 PITA;miRanda;miRNATAP -0.333446337886203 0.00137735387479576 NA NA NA hsa-miR-320b AKT3 -0.23561798088153 0.859222532827992 0.457269233600447 0.539326812115034 PITA;miRanda;miRNATAP -0.247020375326149 0.00854841822062789 NA NA NA hsa-miR-335-3p AKT3 -0.244830745789445 0.88450019116631 0.457269233600447 0.539326812115034 mirMAP -0.579661626156677 1.71660731221086e-14 NA NA NA hsa-miR-33a-3p AKT3 -0.794543849238581 0.0105203072007922 0.457269233600447 0.539326812115034 mirMAP -0.48908545949649 5.69174183767199e-12 NA NA NA hsa-miR-340-5p AKT3 -0.00276909425328853 0.99757361161055 0.457269233600447 0.539326812115034 mirMAP -0.282303409119482 0.00600476945925659 NA NA NA hsa-miR-362-3p AKT3 -0.721040238345347 0.0345881362485733 0.457269233600447 0.539326812115034 miRanda -0.415414242264488 1.82625494243827e-09 NA NA NA hsa-miR-362-5p AKT3 -0.26647467080141 0.752024885130738 0.457269233600447 0.539326812115034 PITA;TargetScan;miRNATAP -0.516617267683569 4.2053666241316e-16 NA NA NA hsa-miR-369-3p AKT3 0.116576891957687 0.83230082995912 0.457269233600447 0.539326812115034 mirMAP -0.2347933374382 0.00901179401751285 NA NA NA hsa-miR-374a-5p AKT3 -0.343007247142618 0.766921280269271 0.457269233600447 0.539326812115034 mirMAP -0.579942468779622 2.643062323348e-06 NA NA NA hsa-miR-374b-5p AKT3 -0.285682091626878 0.83569830479965 0.457269233600447 0.539326812115034 mirMAP -0.684416910019692 6.98155817205318e-09 NA NA NA hsa-miR-421 AKT3 -0.182032017078616 0.734704500318599 0.457269233600447 0.539326812115034 miRanda;mirMAP -0.463766741666901 1.36843495165118e-08 NA NA NA hsa-miR-424-5p AKT3 0.247080963500746 0.870154571783568 0.457269233600447 0.539326812115034 miRNATAP -0.239499066096292 0.00104453067376223 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth liver cancer hsa-miR-501-3p AKT3 -0.753812576327832 0.552763280802254 0.457269233600447 0.539326812115034 miRNATAP -0.497935902986368 2.06014814106823e-10 NA NA NA hsa-miR-502-3p AKT3 -0.481234445251923 0.514301076452422 0.457269233600447 0.539326812115034 miRNATAP -0.644160673294049 1.58962279838432e-12 NA NA NA hsa-miR-502-5p AKT3 -0.708507838520586 0.0261309781860104 0.457269233600447 0.539326812115034 PITA;miRNATAP -0.409328372897747 4.31887851181114e-09 NA NA NA hsa-miR-505-3p AKT3 -0.469094267152605 0.690382680489578 0.457269233600447 0.539326812115034 mirMAP -0.774927841273818 6.77311058531751e-15 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-548o-3p AKT3 -0.191447572716994 0.517725546183501 0.457269233600447 0.539326812115034 mirMAP -0.314174287829114 7.58105126731538e-05 NA NA NA hsa-miR-577 AKT3 -1.06238199218774 0.326056761787754 0.457269233600447 0.539326812115034 mirMAP -0.383091519653111 6.42065724452006e-20 NA NA NA hsa-miR-663b AKT3 0.101100389887233 0.814989939749933 0.457269233600447 0.539326812115034 PITA -0.247711064601903 1.07528758067609e-05 NA NA NA hsa-miR-769-5p AKT3 -0.306614906942583 0.735704301598833 0.457269233600447 0.539326812115034 PITA;miRNATAP -0.8409977584726 1.11686042031466e-14 NA NA NA hsa-miR-93-5p AKT3 -0.611073677204699 0.825297877093193 0.457269233600447 0.539326812115034 miRNATAP -0.762020096686085 6.75211862260925e-18 NA NA NA hsa-miR-335-3p ANGPT1 -0.244830745789445 0.88450019116631 0.0977778089466597 0.805357495886648 mirMAP -0.384135116602422 1.01159777273493e-06 NA NA NA hsa-miR-338-5p ANGPT1 0.484769112400393 0.393961930708873 0.0977778089466597 0.805357495886648 PITA;miRNATAP -0.177740364299624 0.00518868401909091 NA NA NA hsa-miR-429 ANGPT1 -0.456485631615963 0.806240953400535 0.0977778089466597 0.805357495886648 miRanda -0.543644561703191 4.1805658622515e-17 NA NA NA hsa-miR-486-5p ANGPT1 -0.547739229538641 0.696404149927963 0.0977778089466597 0.805357495886648 miRanda -0.160538642519606 0.0064962448168831 NA NA NA hsa-miR-590-3p ANGPT1 -0.279244755376859 0.59126669933662 0.0977778089466597 0.805357495886648 PITA;miRanda;mirMAP -0.606219096542099 2.81190990033823e-19 NA NA NA hsa-miR-135b-5p ANGPT2 0.631573976263484 0.610028066417462 0.309392894337764 0.670261224109307 MirTarget -0.105051791297292 0.00265741114691333 NA NA NA hsa-miR-142-5p ANGPT2 -0.118920788314118 0.929665277963083 0.309392894337764 0.670261224109307 MirTarget -0.150339075137481 0.00359413890982174 NA NA NA hsa-miR-374b-5p ANGPT2 -0.285682091626878 0.83569830479965 0.309392894337764 0.670261224109307 mirMAP -0.265580585116253 0.00080942089212346 NA NA NA hsa-miR-429 ANGPT2 -0.456485631615963 0.806240953400535 0.309392894337764 0.670261224109307 miRanda -0.161149664784058 0.00035323349458173 NA NA NA hsa-miR-491-3p ANGPT2 -0.513850326596847 0.137836285146052 0.309392894337764 0.670261224109307 MirTarget;miRNATAP -0.161241074495523 0.000757336703134151 NA NA NA hsa-miR-590-3p ANGPT2 -0.279244755376859 0.59126669933662 0.309392894337764 0.670261224109307 miRanda -0.161585691174076 0.000702866411229349 NA NA NA hsa-miR-181c-5p ARF6 0.042951891660695 0.969159991881861 -0.139475331875474 0.936360829879093 MirTarget -0.179897879440496 7.24199992807218e-08 NA NA NA hsa-miR-181d-5p ARF6 0.14926527647499 0.888000971478017 -0.139475331875474 0.936360829879093 MirTarget -0.133070248809972 4.12859414552947e-07 NA NA NA hsa-miR-199a-5p ARF6 0.157247797504494 0.935797462797012 -0.139475331875474 0.936360829879093 MirTarget;PITA;miRanda;miRNATAP -0.120673191487592 0.000847706550624472 NA NA NA hsa-miR-217 ARF6 0.341080669095094 0.760998144794468 -0.139475331875474 0.936360829879093 miRanda -0.111878407509716 3.41691976039197e-06 NA NA NA hsa-miR-218-5p ARF6 0.233108057313884 0.810208076649842 -0.139475331875474 0.936360829879093 MirTarget -0.108050046064935 0.000347024710983712 NA NA NA hsa-miR-23a-3p ARF6 -0.122198715333656 0.962717452143511 -0.139475331875474 0.936360829879093 MirTarget -0.164060837310284 0.00687847845292132 NA NA NA hsa-let-7a-5p BCL2L1 -0.0620211756550422 0.985006886285188 0.242557541702429 0.890959530804569 TargetScan;miRNATAP -0.267237022843277 0.00149660612153832 26915294;20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA poor survival; lung cancer;liver cancer hsa-let-7a-3p BDNF -0.215598045625677 0.85543299203799 0.502522334318129 0.169334891177907 MirTarget;miRNATAP -0.244157318378319 0.00935451173762819 NA NA NA hsa-miR-15a-5p BDNF -0.0674049094129128 0.964835434214123 0.502522334318129 0.169334891177907 MirTarget;miRNATAP -0.355665776038132 0.000462651707811393 26581909 MicroRNA 15a 5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF; BDNF was then overexpressed in HepG2 and SNU-182 cells to evaluate its selective effect on miR-15a-5p in HCC modulation; MiR-15a-5p selectively and negatively regulated BDNF at both gene and protein levels in HCC cells; Forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-15a-5p on HCC proliferation and cell division in vitro; Our study demonstrated that miR-15a-5p is a tumor suppressor in HCC and its regulation is through BDNF in HCC liver cancer hsa-miR-15b-5p BDNF -0.272614787130877 0.87096541832188 0.502522334318129 0.169334891177907 MirTarget;miRNATAP -0.321617462225248 0.000753073059525485 NA NA NA hsa-miR-16-5p BDNF 0.0135949734723564 0.994476223855607 0.502522334318129 0.169334891177907 MirTarget;miRNATAP -0.341750126964866 0.000321385062215879 NA NA NA hsa-miR-191-5p BDNF -0.482483793839469 0.815353309051705 0.502522334318129 0.169334891177907 miRNATAP -0.334294944807502 0.000226992770607199 NA NA NA hsa-miR-210-3p BDNF -0.531610638853144 0.78220772117333 0.502522334318129 0.169334891177907 miRNAWalker2_validate;miRTarBase -0.183642191494302 0.0001042604221863 NA NA NA hsa-miR-26b-3p BDNF -0.363222538866814 0.681115126930068 0.502522334318129 0.169334891177907 MirTarget -0.268475122696643 0.00218986725906013 NA NA NA hsa-miR-29b-1-5p BDNF -0.642348119412534 0.293891497238796 0.502522334318129 0.169334891177907 mirMAP -0.212902366897635 0.000389282449514205 NA NA NA hsa-miR-30b-5p BDNF -0.0121430518253582 0.994622896704513 0.502522334318129 0.169334891177907 miRNATAP -0.260284489869932 0.00172972096789126 NA NA NA hsa-miR-32-3p BDNF -0.568003960723004 0.13133163420273 0.502522334318129 0.169334891177907 miRNATAP -0.291628274452174 1.27978861287945e-06 NA NA NA hsa-miR-339-5p BDNF -0.300425087100667 0.712912847076788 0.502522334318129 0.169334891177907 miRanda -0.263405527708753 0.000132027992538123 NA NA NA hsa-miR-33a-3p BDNF -0.794543849238581 0.0105203072007922 0.502522334318129 0.169334891177907 mirMAP -0.189014402176148 0.0084884107105508 NA NA NA hsa-miR-452-3p BDNF -0.167134177977311 0.799008246175244 0.502522334318129 0.169334891177907 MirTarget -0.167787891127089 0.00525081101096434 NA NA NA hsa-miR-577 BDNF -1.06238199218774 0.326056761787754 0.502522334318129 0.169334891177907 mirMAP;miRNATAP -0.178001475560175 4.47308472492026e-05 NA NA NA hsa-miR-589-3p BDNF -0.835836305204965 0.0112001563801511 0.502522334318129 0.169334891177907 MirTarget -0.292493758312755 6.69029402753748e-06 NA NA NA hsa-miR-589-5p BDNF -0.448771545046784 0.722725226273464 0.502522334318129 0.169334891177907 miRNATAP -0.37518450820671 0.00123645876452662 NA NA NA hsa-miR-590-3p BDNF -0.279244755376859 0.59126669933662 0.502522334318129 0.169334891177907 miRanda;mirMAP;miRNATAP -0.323632810694054 3.35708815948861e-06 NA NA NA hsa-miR-7-1-3p BDNF -0.462485777435991 0.665899751398166 0.502522334318129 0.169334891177907 MirTarget -0.33546008099557 4.33647161661503e-05 NA NA NA hsa-miR-30a-5p BRAP 0.219472325612346 0.933954023293816 -0.114376149991255 0.919829673220814 miRNATAP -0.104192116568528 0.00135689797696573 NA NA NA hsa-miR-181c-5p CALM1 0.042951891660695 0.969159991881861 -0.188496525639611 0.925623107764436 miRNATAP -0.104817888688846 0.000118852100174694 NA NA NA hsa-miR-664a-3p CALM1 -0.00395670341813714 0.996119749372707 -0.188496525639611 0.925623107764436 mirMAP -0.103815555097622 0.00153035327996623 NA NA NA hsa-miR-130a-3p CALM2 0.0910074087716906 0.929098200371948 0.00321909074911275 0.99874929530128 miRNATAP -0.116218538768413 5.36197377179819e-05 NA NA NA hsa-miR-199a-5p CALM2 0.157247797504494 0.935797462797012 0.00321909074911275 0.99874929530128 miRanda -0.107847162387061 0.00051076768242321 NA NA NA hsa-miR-143-5p CDC42 0.10589969923845 0.933358732923556 -0.145789682850817 0.93702110357077 miRNATAP -0.116073615725907 2.04088148084208e-05 NA NA NA hsa-miR-23b-3p CHUK -0.10822254818704 0.961352920317636 -0.096549775668116 0.93218060129343 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.136584882734319 0.00997084019729046 NA NA NA hsa-miR-106a-5p CSF1 -0.203919267842652 0.802213958426804 -0.252531366178799 0.777200619662166 miRNATAP -0.323395441681629 4.18955463178332e-06 NA NA NA hsa-miR-106b-5p CSF1 -0.297128724729339 0.869294443540749 -0.252531366178799 0.777200619662166 miRNATAP -0.608218348053118 5.66934155230753e-15 NA NA NA hsa-miR-128-3p CSF1 -0.442192625156042 0.783886533572187 -0.252531366178799 0.777200619662166 MirTarget -0.260482065672388 0.00495935713439579 22909061 By mutations in putative miRNA targets in CSF-1 mRNA 3'UTR we identified a common target for both miR-128 and miR-152; We have also found that both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro two major aspects of the metastatic potential of cancer cells; Our results provide the evidence for a mechanism by which miR-128 and miR-152 down-regulate CSF-1 an important regulator of ovarian cancer motility ovarian cancer hsa-miR-130b-3p CSF1 -0.221667315324818 0.824660172394714 -0.252531366178799 0.777200619662166 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.469017258632817 4.47777835200458e-11 22005523 CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system; CSF-1 expression was negatively associated with miR-130b level in ovarian tissues and cell lines; Luciferase assay validated CSF-1 is a direct target of miR-130b; Knock-down of CSF-1 sensitized ovarian cancer cells to anticancer drugs and could partially attenuate the resistance inducing effect of miR-130b inhibitors; Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1 and the silencing of miR-130b may be mediated by DNA methylation drug resistance ovarian cancer hsa-miR-148a-3p CSF1 -0.101286586375016 0.976980454193186 -0.252531366178799 0.777200619662166 miRNATAP -0.38027808141193 1.42574348879762e-07 NA NA NA hsa-miR-148b-3p CSF1 -0.202106692287125 0.911884960581838 -0.252531366178799 0.777200619662166 miRNAWalker2_validate -0.331580756020697 0.00151294828294846 NA NA NA hsa-miR-15a-5p CSF1 -0.0674049094129128 0.964835434214123 -0.252531366178799 0.777200619662166 miRNATAP -0.309212803733021 0.000332690214416442 NA NA NA hsa-miR-15b-5p CSF1 -0.272614787130877 0.87096541832188 -0.252531366178799 0.777200619662166 miRNATAP -0.293109396578999 0.000289376414871647 NA NA NA hsa-miR-16-5p CSF1 0.0135949734723564 0.994476223855607 -0.252531366178799 0.777200619662166 miRNATAP -0.392458405549128 8.25923462604606e-07 NA NA NA hsa-miR-17-5p CSF1 -0.175448849583061 0.934544015912731 -0.252531366178799 0.777200619662166 TargetScan;miRNATAP -0.44082146001902 1.620425786916e-13 NA NA NA hsa-miR-20a-5p CSF1 -0.179153323927949 0.928118119139752 -0.252531366178799 0.777200619662166 miRNATAP -0.382513353413265 1.53754034472633e-10 NA NA NA hsa-miR-23a-5p CSF1 -0.697299079757902 0.1188853327314 -0.252531366178799 0.777200619662166 MirTarget -0.132006391764098 0.00436897209843804 NA NA NA hsa-miR-27a-3p CSF1 -0.123902317731458 0.958804393510999 -0.252531366178799 0.777200619662166 MirTarget;miRNATAP -0.369748973744669 0.00128394330593675 NA NA NA hsa-miR-301a-3p CSF1 -0.105312511901769 0.831686745977347 -0.252531366178799 0.777200619662166 MirTarget;miRNATAP -0.282433229783897 4.57168245268115e-06 NA NA NA hsa-miR-30b-5p CSF1 -0.0121430518253582 0.994622896704513 -0.252531366178799 0.777200619662166 miRNAWalker2_validate -0.458638412092148 1.27845700007534e-11 NA NA NA hsa-miR-30c-5p CSF1 -0.298383882401475 0.865809030482001 -0.252531366178799 0.777200619662166 miRNAWalker2_validate -0.474161022421685 1.96369136215612e-06 NA NA NA hsa-miR-335-5p CSF1 -0.0284895175847679 0.973380867832231 -0.252531366178799 0.777200619662166 miRNAWalker2_validate -0.486977097737539 4.29981931496918e-15 NA NA NA hsa-miR-423-5p CSF1 -0.140317642654 0.912448846587903 -0.252531366178799 0.777200619662166 miRNATAP -0.314514296711895 0.000276407128361644 NA NA NA hsa-miR-424-5p CSF1 0.247080963500746 0.870154571783568 -0.252531366178799 0.777200619662166 miRNATAP -0.197377996550209 0.000989167907239471 NA NA NA hsa-miR-429 CSF1 -0.456485631615963 0.806240953400535 -0.252531366178799 0.777200619662166 PITA;miRanda;miRNATAP -0.356022558690501 7.65693302761238e-11 NA NA NA hsa-miR-454-3p CSF1 -0.101514866328011 0.843545158256191 -0.252531366178799 0.777200619662166 MirTarget;miRNATAP -0.506936701110765 1.09802459391483e-09 NA NA NA hsa-miR-505-3p CSF1 -0.469094267152605 0.690382680489578 -0.252531366178799 0.777200619662166 miRNAWalker2_validate -0.368339423119592 1.65823672001737e-05 NA NA NA hsa-miR-532-3p CSF1 -0.496590111092324 0.682889021782543 -0.252531366178799 0.777200619662166 MirTarget;PITA -0.362974372426505 8.1850463876991e-09 NA NA NA hsa-miR-532-5p CSF1 -0.349665553500088 0.878948352437467 -0.252531366178799 0.777200619662166 miRNATAP -0.292494381006082 3.91823087607345e-05 NA NA NA hsa-miR-93-5p CSF1 -0.611073677204699 0.825297877093193 -0.252531366178799 0.777200619662166 miRNATAP -0.452469432502215 2.22815048830137e-09 NA NA NA hsa-miR-939-5p CSF1 -0.311196961912953 0.304447903545905 -0.252531366178799 0.777200619662166 MirTarget -0.270484446518418 1.48952032100827e-05 NA NA NA hsa-miR-940 CSF1 -0.225788347550697 0.680055767105815 -0.252531366178799 0.777200619662166 MirTarget;PITA;miRNATAP -0.239805433420129 2.16547642012011e-06 NA NA NA hsa-miR-96-5p CSF1 0.0854810872029343 0.923087820185031 -0.252531366178799 0.777200619662166 miRNATAP -0.429133319834493 2.4296675097054e-13 NA NA NA hsa-miR-1275 CSF1R -0.831342050607648 0.0803795852164229 -0.28202175069937 0.798643363749792 MirTarget -0.28098420617344 8.4192050908413e-06 NA NA NA hsa-miR-339-5p CSF1R -0.300425087100667 0.712912847076788 -0.28202175069937 0.798643363749792 miRanda -0.566751474398416 8.7294081360447e-13 NA NA NA hsa-miR-34a-5p CSF1R -0.50188164870224 0.742034237185732 -0.28202175069937 0.798643363749792 MirTarget;miRNATAP -0.284183148962691 0.00893929195617197 NA NA NA hsa-miR-30c-2-3p EFNA1 0.242912714924037 0.746927269997556 0.261639312685932 0.866820045372497 MirTarget -0.317632550673705 9.802938660626e-08 NA NA NA hsa-miR-9-5p EFNA1 0.447601333076892 0.795015262386155 0.261639312685932 0.866820045372497 miRNAWalker2_validate;miRNATAP -0.102699435989511 0.0018786584099939 NA NA NA hsa-miR-30a-5p EFNA3 0.219472325612346 0.933954023293816 0.318286597903787 0.787986239865054 MirTarget;mirMAP;miRNATAP -0.397827293631223 0.000671423158582254 NA NA NA hsa-let-7a-3p EFNA5 -0.215598045625677 0.85543299203799 0.503344091670042 0.404435726866389 miRNATAP -0.40543498468815 0.00989547054421855 NA NA NA hsa-miR-1275 EFNA5 -0.831342050607648 0.0803795852164229 0.503344091670042 0.404435726866389 mirMAP -0.336952379729342 0.000142905613045414 NA NA NA hsa-miR-144-3p EFNA5 0.0482420655617901 0.935871997593533 0.503344091670042 0.404435726866389 miRNATAP -0.240640043897073 0.00527817303128666 NA NA NA hsa-miR-15b-3p EFNA5 -0.557749208157585 0.609181305423188 0.503344091670042 0.404435726866389 mirMAP -0.636174513488425 9.88897797844726e-06 NA NA NA hsa-miR-186-5p EFNA5 -0.318786974828757 0.85412722938961 0.503344091670042 0.404435726866389 mirMAP -0.686424203917528 0.00053173732928788 NA NA NA hsa-miR-188-3p EFNA5 -0.292769686102066 0.475019668859617 0.503344091670042 0.404435726866389 miRNATAP -0.377651870178639 9.40265990288421e-05 NA NA NA hsa-miR-19a-3p EFNA5 -0.206793507801887 0.844637784802316 0.503344091670042 0.404435726866389 miRNATAP -0.703255106639825 6.85891867099046e-10 NA NA NA hsa-miR-19b-3p EFNA5 -0.0268530183621474 0.986656783046572 0.503344091670042 0.404435726866389 miRNATAP -0.914239459613248 1.357710407562e-11 NA NA NA hsa-miR-200b-3p EFNA5 -0.426401948379212 0.863957108574195 0.503344091670042 0.404435726866389 TargetScan -0.520085660578648 0.000152482558219217 NA NA NA hsa-miR-200c-3p EFNA5 -0.437282635857873 0.887118598436407 0.503344091670042 0.404435726866389 miRNATAP -0.446832966136964 0.00165673178708209 NA NA NA hsa-miR-20a-3p EFNA5 0.456808229166028 0.57674056136504 0.503344091670042 0.404435726866389 mirMAP -0.624232248464653 5.34824307417745e-11 NA NA NA hsa-miR-21-3p EFNA5 -0.395016549347053 0.87819982773565 0.503344091670042 0.404435726866389 mirMAP -0.626482565161211 0.000184113163579591 NA NA NA hsa-miR-26a-2-3p EFNA5 -0.427772454814258 0.28776911697575 0.503344091670042 0.404435726866389 MirTarget -0.399126735290235 0.00178092281587676 NA NA NA hsa-miR-29a-3p EFNA5 0.01127474410284 0.996977020481272 0.503344091670042 0.404435726866389 miRNATAP -0.856917315728278 2.93708194215123e-06 NA NA NA hsa-miR-29b-3p EFNA5 -0.104016192263954 0.958988036765397 0.503344091670042 0.404435726866389 miRNATAP -0.819756027513277 1.97493348943382e-09 NA NA NA hsa-miR-32-3p EFNA5 -0.568003960723004 0.13133163420273 0.503344091670042 0.404435726866389 mirMAP -0.351974953685148 0.000563095148940417 NA NA NA hsa-miR-335-3p EFNA5 -0.244830745789445 0.88450019116631 0.503344091670042 0.404435726866389 mirMAP -0.892967923940506 3.85874646311541e-13 NA NA NA hsa-miR-335-5p EFNA5 -0.0284895175847679 0.973380867832231 0.503344091670042 0.404435726866389 miRNAWalker2_validate -0.632382481020738 6.92545140685037e-07 NA NA NA hsa-miR-362-3p EFNA5 -0.721040238345347 0.0345881362485733 0.503344091670042 0.404435726866389 miRanda -0.430670891465251 0.000168665031366013 NA NA NA hsa-miR-369-3p EFNA5 0.116576891957687 0.83230082995912 0.503344091670042 0.404435726866389 MirTarget;miRNATAP -0.414836438291738 0.004253651551035 NA NA NA hsa-miR-378a-3p EFNA5 -0.466787210598086 0.795055970353024 0.503344091670042 0.404435726866389 miRNATAP -0.449935303931369 0.0041586699064027 NA NA NA hsa-miR-421 EFNA5 -0.182032017078616 0.734704500318599 0.503344091670042 0.404435726866389 mirMAP -0.602549859194601 6.73004723958215e-06 NA NA NA hsa-miR-429 EFNA5 -0.456485631615963 0.806240953400535 0.503344091670042 0.404435726866389 miRNATAP -0.45771503418913 3.67519005401933e-05 NA NA NA hsa-miR-450b-5p EFNA5 -0.0136687538973108 0.983149761399849 0.503344091670042 0.404435726866389 mirMAP -0.438237343684117 0.00298313188299684 NA NA NA hsa-miR-501-5p EFNA5 -0.834032628506285 0.0582725160418523 0.503344091670042 0.404435726866389 mirMAP -0.398453225685377 0.000138428863543361 NA NA NA hsa-miR-542-3p EFNA5 0.188168046511374 0.909252939431573 0.503344091670042 0.404435726866389 miRanda;mirMAP -0.517547865646544 0.00264291637237236 NA NA NA hsa-miR-577 EFNA5 -1.06238199218774 0.326056761787754 0.503344091670042 0.404435726866389 mirMAP -0.285907558216753 9.11226925221999e-05 NA NA NA hsa-miR-590-3p EFNA5 -0.279244755376859 0.59126669933662 0.503344091670042 0.404435726866389 miRanda;mirMAP -0.44147931715964 0.000171151576566218 NA NA NA hsa-miR-592 EFNA5 -0.177670083168544 0.856226890424691 0.503344091670042 0.404435726866389 mirMAP;miRNATAP -0.238609254751356 5.3801465264549e-05 NA NA NA hsa-miR-7-1-3p EFNA5 -0.462485777435991 0.665899751398166 0.503344091670042 0.404435726866389 mirMAP -0.392759658085601 0.00460135451492935 NA NA NA hsa-miR-92a-3p EFNA5 0.0278830870766349 0.993247426671713 0.503344091670042 0.404435726866389 miRNAWalker2_validate -0.916308273683341 6.51205629747335e-11 NA NA NA hsa-miR-96-5p EFNA5 0.0854810872029343 0.923087820185031 0.503344091670042 0.404435726866389 TargetScan -0.342744854452614 0.00479691915332912 NA NA NA hsa-miR-146a-5p EGFR -0.581292803346906 0.73685134936757 -0.158757048599807 0.889536836433204 miRNAWalker2_validate -0.120342498153531 0.00926534743929207 25242818;22161865;25596948;24895573;25417703;23555954;24839931;21632853 Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;MiR 146a suppresses tumor growth and progression by targeting EGFR pathway and in a p ERK dependent manner in castration resistant prostate cancer; Mechanistic studies revealed that miR-146a repressed the expression of EGFR through binding to its 3'-untranslated region; Our findings suggest that ubiquitous loss of miR-146a is a critical mechanism for overexpression of EGFR in CRPC which is crucial to better understanding the pathogenesis of CRPC;Furthermore the expressions of bax and cleaved-caspase-3 mainly were increased in control and overexpression miR-146a groups however the expression of EGFR was inverse; All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells which was performed by up-regulating miR-146a expression then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways and inhibiting invasion through down-regulating the expression of EGFR;Furthermore western blot showed that miR-146a mimic downregulated EGFR ERK1/2 and stat5 signalings; These effects were less potent compared to that of a siRNA targeting EGFR a known target gene of miR-146a; Moreover miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents;Here we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a; We show that BRCA1 binds to MIR146A promoter and activates transcription which in turn attenuates EGFR expression;In functional experiments miR-146a suppressed cell growth induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines H358 H1650 H1975 HCC827 and H292 miR-146a also inhibited the migratory capacity of these NSCLC cells; On the other hand miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR including both TKIs gefitinib erlotinib and afatinib and a monoclonal antibody cetuximab; Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling;Deregulation of miR 146a expression in a mouse model of pancreatic cancer affecting EGFR signaling; Treatment of PC cells with CDF a novel synthetic compound led to re-expression of miR-146a resulting in the down-regulation of EGFR expression; Further knock-down of miR-146a in AsPC-1 cells led to the up-regulation of EGFR expression and showed increased clonogenic growth; In addition knock-down of EGFR by EGFR siRNA transfection of parental AsPC-1 cells and AsPC-1 cells stably transfected with pre-miR-146a resulted in decreased invasive capacity which was further confirmed by reduced luciferase activity in cells transfected with pMIR-Luc reporter vector containing miR-146a binding site; Collectively these results suggest that the loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling and that re-expression of miR-146a by CDF treatment could be useful in designing personalized strategy for the treatment of human PC;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;progression;;;;;; pancreatic cancer;prostate cancer;breast cancer;liver cancer;breast cancer;lung squamous cell cancer;pancreatic cancer;gastric cancer hsa-miR-148b-5p EGFR -0.236618793990305 0.43925706879726 -0.158757048599807 0.889536836433204 mirMAP -0.146751875727126 0.00334551627619675 NA NA NA hsa-miR-32-3p EGFR -0.568003960723004 0.13133163420273 -0.158757048599807 0.889536836433204 mirMAP -0.127312035684583 0.00126420267436394 NA NA NA hsa-miR-501-5p EGFR -0.834032628506285 0.0582725160418523 -0.158757048599807 0.889536836433204 mirMAP -0.109121341773138 0.00737323655722487 NA NA NA hsa-miR-10a-5p ETS1 0.0740585720685925 0.983770933356406 -0.0196786801958062 0.988570737194681 miRNAWalker2_validate -0.301811592107525 8.99023802645298e-07 NA NA NA hsa-miR-1180-3p ETS1 -0.813058904053004 0.363047150051413 -0.0196786801958062 0.988570737194681 MirTarget -0.166166025777114 0.00467925218218171 NA NA NA hsa-miR-1275 ETS1 -0.831342050607648 0.0803795852164229 -0.0196786801958062 0.988570737194681 MirTarget -0.159486762599976 9.20187381412234e-05 NA NA NA hsa-miR-130b-5p ETS1 -0.6472141103776 0.379096015222509 -0.0196786801958062 0.988570737194681 MirTarget -0.437583629536325 3.5545325504437e-13 NA NA NA hsa-miR-141-3p ETS1 -0.31994058840327 0.87774106909065 -0.0196786801958062 0.988570737194681 mirMAP -0.352291962504491 3.69262597575223e-11 NA NA NA hsa-miR-141-5p ETS1 -0.354590233549885 0.867642456336402 -0.0196786801958062 0.988570737194681 mirMAP -0.254030060203649 1.44385697247359e-05 NA NA NA hsa-miR-148b-5p ETS1 -0.236618793990305 0.43925706879726 -0.0196786801958062 0.988570737194681 MirTarget -0.286933347492008 9.88946637762422e-07 NA NA NA hsa-miR-16-1-3p ETS1 0.151694812889216 0.733736501874638 -0.0196786801958062 0.988570737194681 MirTarget -0.220103682455186 0.000114748693662512 NA NA NA hsa-miR-186-5p ETS1 -0.318786974828757 0.85412722938961 -0.0196786801958062 0.988570737194681 mirMAP -0.442963405143208 8.67645493840587e-07 NA NA NA hsa-miR-193a-3p ETS1 -0.247265785363732 0.654363581941634 -0.0196786801958062 0.988570737194681 miRanda;miRNATAP -0.238369470810885 8.79905322388267e-05 NA NA NA hsa-miR-193b-3p ETS1 0.0672068426635715 0.951480422273678 -0.0196786801958062 0.988570737194681 miRNAWalker2_validate;miRTarBase -0.170953289848092 0.00491292246572031 20655737 CCND1 and ETS1 were revealed to be regulated by miR-193b directly liver cancer hsa-miR-200a-3p ETS1 -0.367034437440907 0.851059894150266 -0.0196786801958062 0.988570737194681 mirMAP -0.296468913909998 1.67874661496947e-08 NA NA NA hsa-miR-200b-3p ETS1 -0.426401948379212 0.863957108574195 -0.0196786801958062 0.988570737194681 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.352829732598216 1.26675897064258e-08 NA NA NA hsa-miR-200c-3p ETS1 -0.437282635857873 0.887118598436407 -0.0196786801958062 0.988570737194681 MirTarget;miRNATAP -0.329589240535493 2.88986705251086e-07 NA NA NA hsa-miR-221-3p ETS1 0.0906940388127513 0.959121118272534 -0.0196786801958062 0.988570737194681 miRTarBase;miRNATAP -0.359103809011515 6.15985606796675e-06 21711453 To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions melanoma hsa-miR-222-3p ETS1 -0.0265849318772702 0.984005474689108 -0.0196786801958062 0.988570737194681 miRNAWalker2_validate;miRTarBase;miRNATAP -0.376881064613996 8.73604606022674e-08 21711453 Constitutive activation of the ETS 1 miR 222 circuitry in metastatic melanoma; We demonstrate that the proto-oncogene ETS-1 involved in the pathogenesis of cancers of different origin is a transcriptional regulator of miR-222 by direct binding to its promoter region; Differently from 293FT cells or early stage melanomas where unphosphorylated ETS-1 represses miR-222 transcription in metastatic melanoma the constitutively Thr-38 phosphorylated fraction of ETS-1 induces miR-222; To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions staging melanoma hsa-miR-23a-3p ETS1 -0.122198715333656 0.962717452143511 -0.0196786801958062 0.988570737194681 mirMAP -0.368325668747467 0.00232549927479705 NA NA NA hsa-miR-29a-5p ETS1 -0.31835175571979 0.600442757817281 -0.0196786801958062 0.988570737194681 MirTarget;miRNATAP -0.45976021980224 1.70225746264862e-16 NA NA NA hsa-miR-30c-5p ETS1 -0.298383882401475 0.865809030482001 -0.0196786801958062 0.988570737194681 miRNAWalker2_validate -0.404929338352135 8.15421464228691e-06 NA NA NA hsa-miR-30d-3p ETS1 -0.123474741320298 0.814905367625791 -0.0196786801958062 0.988570737194681 mirMAP -0.324607185524387 6.01440806836751e-06 NA NA NA hsa-miR-335-3p ETS1 -0.244830745789445 0.88450019116631 -0.0196786801958062 0.988570737194681 mirMAP -0.410022771060535 4.73527097707741e-13 NA NA NA hsa-miR-362-3p ETS1 -0.721040238345347 0.0345881362485733 -0.0196786801958062 0.988570737194681 miRanda -0.26882431720009 2.34965367327084e-07 NA NA NA hsa-miR-369-3p ETS1 0.116576891957687 0.83230082995912 -0.0196786801958062 0.988570737194681 mirMAP -0.262427040016068 7.53570830558695e-05 NA NA NA hsa-miR-421 ETS1 -0.182032017078616 0.734704500318599 -0.0196786801958062 0.988570737194681 miRanda;mirMAP;miRNATAP -0.33319734984774 4.71214872020336e-08 NA NA NA hsa-miR-429 ETS1 -0.456485631615963 0.806240953400535 -0.0196786801958062 0.988570737194681 MirTarget;PITA;miRanda;miRNATAP -0.335116803121766 1.26068682642576e-11 NA NA NA hsa-miR-450b-5p ETS1 -0.0136687538973108 0.983149761399849 -0.0196786801958062 0.988570737194681 miRNATAP -0.183611268048515 0.00702561132170698 NA NA NA hsa-miR-501-5p ETS1 -0.834032628506285 0.0582725160418523 -0.0196786801958062 0.988570737194681 mirMAP -0.262323856291408 2.92216207867234e-08 NA NA NA hsa-miR-502-5p ETS1 -0.708507838520586 0.0261309781860104 -0.0196786801958062 0.988570737194681 miRNATAP -0.292154869114798 2.05058301228912e-08 NA NA NA hsa-miR-532-3p ETS1 -0.496590111092324 0.682889021782543 -0.0196786801958062 0.988570737194681 MirTarget;PITA;miRNATAP -0.398884412557788 1.13231320504458e-12 NA NA NA hsa-miR-576-5p ETS1 -0.506413219377403 0.417187951364173 -0.0196786801958062 0.988570737194681 mirMAP -0.304157307373772 2.29175697596577e-06 NA NA NA hsa-miR-590-3p ETS1 -0.279244755376859 0.59126669933662 -0.0196786801958062 0.988570737194681 PITA;miRanda;mirMAP -0.274867897154219 2.60324466362137e-07 NA NA NA hsa-miR-590-5p ETS1 -0.547819833829572 0.472735645776647 -0.0196786801958062 0.988570737194681 miRanda -0.388510943726615 1.60282481831743e-12 NA NA NA hsa-miR-625-5p ETS1 -0.690759472145277 0.210306534567564 -0.0196786801958062 0.988570737194681 MirTarget -0.12716017049394 0.0080459835833497 NA NA NA hsa-miR-660-5p ETS1 -0.476129334484339 0.694082832658925 -0.0196786801958062 0.988570737194681 MirTarget -0.414959402842465 1.40821859805382e-10 NA NA NA hsa-miR-7-1-3p ETS1 -0.462485777435991 0.665899751398166 -0.0196786801958062 0.988570737194681 mirMAP -0.208178361998211 0.0010759030180543 NA NA NA hsa-miR-769-5p ETS1 -0.306614906942583 0.735704301598833 -0.0196786801958062 0.988570737194681 miRNATAP -0.509376179964192 8.72465157474702e-10 NA NA NA hsa-miR-940 ETS1 -0.225788347550697 0.680055767105815 -0.0196786801958062 0.988570737194681 MirTarget;miRNATAP -0.242541028359924 1.0846578828364e-07 NA NA NA hsa-miR-942-5p ETS1 -0.50502396741886 0.50777904281306 -0.0196786801958062 0.988570737194681 MirTarget -0.248032269868288 3.19073149664754e-06 NA NA NA hsa-miR-146b-5p ETS2 -0.402662509440887 0.837510937985091 -0.286044651293262 0.892313732981593 miRanda -0.161026692765516 0.00838012258936569 NA NA NA hsa-miR-452-3p FASLG -0.167134177977311 0.799008246175244 -1.01623663960814 0.0497518030689545 mirMAP -0.300498727144317 0.000506966650214745 NA NA NA hsa-miR-92a-3p FASLG 0.0278830870766349 0.993247426671713 -1.01623663960814 0.0497518030689545 miRNATAP -0.376276337966714 0.00278748481239554 NA NA NA hsa-miR-126-5p FGF1 0.0815213541035824 0.956637332055185 0.817056717165033 0.0360338129925349 mirMAP -0.385963766795316 0.00339122919028115 NA NA NA hsa-miR-1275 FGF1 -0.831342050607648 0.0803795852164229 0.817056717165033 0.0360338129925349 MirTarget -0.234426625474762 0.00025742532980694 NA NA NA hsa-miR-16-1-3p FGF1 0.151694812889216 0.733736501874638 0.817056717165033 0.0360338129925349 mirMAP -0.605586522404409 2.09972410475602e-12 NA NA NA hsa-miR-186-5p FGF1 -0.318786974828757 0.85412722938961 0.817056717165033 0.0360338129925349 mirMAP -1.0155361405459 1.0125599886581e-13 NA NA NA hsa-miR-18a-5p FGF1 -0.498318455303917 0.61264091975585 0.817056717165033 0.0360338129925349 MirTarget -0.60434160371127 3.90449003199202e-18 NA NA NA hsa-miR-18b-5p FGF1 -0.0473300652227538 0.899981261531446 0.817056717165033 0.0360338129925349 MirTarget -0.497414084504357 1.23330693858757e-12 NA NA NA hsa-miR-193a-3p FGF1 -0.247265785363732 0.654363581941634 0.817056717165033 0.0360338129925349 PITA -0.313381826112066 0.00108444554830563 NA NA NA hsa-miR-222-5p FGF1 -0.154611068970282 0.819707762805266 0.817056717165033 0.0360338129925349 MirTarget -0.535437056747217 2.28482793706673e-12 NA NA NA hsa-miR-26b-3p FGF1 -0.363222538866814 0.681115126930068 0.817056717165033 0.0360338129925349 MirTarget -0.734270844592521 3.56140435477727e-13 NA NA NA hsa-miR-29a-5p FGF1 -0.31835175571979 0.600442757817281 0.817056717165033 0.0360338129925349 mirMAP -0.700869123417915 1.6307908971127e-15 NA NA NA hsa-miR-320a FGF1 -0.416546433767628 0.840202138616422 0.817056717165033 0.0360338129925349 miRanda -0.463245151210083 0.000132662825849526 NA NA NA hsa-miR-320b FGF1 -0.23561798088153 0.859222532827992 0.817056717165033 0.0360338129925349 miRanda -0.36919906840847 0.000725718517943916 NA NA NA hsa-miR-361-5p FGF1 -0.138735309928775 0.941495130308343 0.817056717165033 0.0360338129925349 miRanda -0.574545150291662 0.00089792986324362 NA NA NA hsa-miR-374a-3p FGF1 -0.118320910531011 0.958176637009264 0.817056717165033 0.0360338129925349 mirMAP -0.501039740161645 6.25400030648256e-07 NA NA NA hsa-miR-429 FGF1 -0.456485631615963 0.806240953400535 0.817056717165033 0.0360338129925349 miRNATAP -0.672751207199376 2.21205294562789e-19 NA NA NA hsa-miR-484 FGF1 -0.179977202691249 0.886333755572375 0.817056717165033 0.0360338129925349 MirTarget;PITA;miRNATAP -0.854875358873338 2.86755681607907e-12 NA NA NA hsa-miR-532-3p FGF1 -0.496590111092324 0.682889021782543 0.817056717165033 0.0360338129925349 miRNATAP -0.579090993770955 6.93746015430313e-11 NA NA NA hsa-miR-550a-5p FGF1 -0.390865630073894 0.535659273352227 0.817056717165033 0.0360338129925349 MirTarget -0.481202126196725 6.09656439029238e-08 NA NA NA hsa-miR-576-5p FGF1 -0.506413219377403 0.417187951364173 0.817056717165033 0.0360338129925349 PITA;mirMAP -0.746010979431166 1.42643113650642e-14 NA NA NA hsa-miR-590-5p FGF1 -0.547819833829572 0.472735645776647 0.817056717165033 0.0360338129925349 MirTarget;miRanda;miRNATAP -0.763780626727086 3.98618728517647e-20 NA NA NA hsa-miR-625-5p FGF1 -0.690759472145277 0.210306534567564 0.817056717165033 0.0360338129925349 MirTarget -0.489273238427581 1.13468194544974e-11 NA NA NA hsa-miR-629-5p FGF1 -0.385679366494342 0.798536530066869 0.817056717165033 0.0360338129925349 MirTarget -0.496856100338096 7.34270954766289e-08 NA NA NA hsa-miR-7-5p FGF1 0.209645143210379 0.773705612298441 0.817056717165033 0.0360338129925349 miRNAWalker2_validate -0.339779616875168 5.53944074838168e-08 NA NA NA hsa-miR-760 FGF1 -0.669469782471462 0.0773517068284613 0.817056717165033 0.0360338129925349 MirTarget;PITA;miRNATAP -0.303186524946084 1.30784299012347e-05 NA NA NA hsa-miR-10a-5p FGF11 0.0740585720685925 0.983770933356406 -0.0753104644635859 0.828389111628698 mirMAP -0.183447717169761 0.00781424110500811 NA NA NA hsa-miR-335-5p FGF11 -0.0284895175847679 0.973380867832231 -0.0753104644635859 0.828389111628698 miRNAWalker2_validate;mirMAP -0.301314897890468 3.3865427403947e-06 NA NA NA hsa-miR-339-5p FGF11 -0.300425087100667 0.712912847076788 -0.0753104644635859 0.828389111628698 miRanda -0.15266312930966 0.0096720714062192 NA NA NA hsa-miR-532-3p FGF11 -0.496590111092324 0.682889021782543 -0.0753104644635859 0.828389111628698 mirMAP -0.193839089005114 0.00273015557871241 NA NA NA hsa-let-7a-3p FGF12 -0.215598045625677 0.85543299203799 -0.0733567813264719 0.90082041524438 MirTarget -0.31967445902099 0.000591732965496754 NA NA NA hsa-let-7f-1-3p FGF12 -0.31101436822914 0.693407210545374 -0.0733567813264719 0.90082041524438 MirTarget -0.346530348049905 0.00665542231614084 NA NA NA hsa-miR-107 FGF12 -0.0365118169251648 0.988364120226869 -0.0733567813264719 0.90082041524438 miRanda -0.449940214923557 0.00151566453905866 NA NA NA hsa-miR-17-5p FGF12 -0.175448849583061 0.934544015912731 -0.0733567813264719 0.90082041524438 TargetScan -0.312407470418788 1.8707426320976e-05 NA NA NA hsa-miR-197-3p FGF12 -0.455489147957159 0.794916582095149 -0.0733567813264719 0.90082041524438 MirTarget -0.349442074406489 0.000122775742485391 NA NA NA hsa-miR-200b-3p FGF12 -0.426401948379212 0.863957108574195 -0.0733567813264719 0.90082041524438 TargetScan -0.399263932943052 7.91026139011957e-07 NA NA NA hsa-miR-29a-5p FGF12 -0.31835175571979 0.600442757817281 -0.0733567813264719 0.90082041524438 MirTarget -0.419708837882208 2.26602339644268e-08 NA NA NA hsa-miR-32-3p FGF12 -0.568003960723004 0.13133163420273 -0.0733567813264719 0.90082041524438 mirMAP -0.238419633289351 8.17883299774707e-05 NA NA NA hsa-miR-335-3p FGF12 -0.244830745789445 0.88450019116631 -0.0733567813264719 0.90082041524438 MirTarget -0.241577032938532 0.00166504582837203 NA NA NA hsa-miR-33a-3p FGF12 -0.794543849238581 0.0105203072007922 -0.0733567813264719 0.90082041524438 mirMAP -0.28084613962831 7.33431744825372e-05 NA NA NA hsa-miR-362-3p FGF12 -0.721040238345347 0.0345881362485733 -0.0733567813264719 0.90082041524438 miRanda -0.210864640223074 0.00209390425937481 NA NA NA hsa-miR-429 FGF12 -0.456485631615963 0.806240953400535 -0.0733567813264719 0.90082041524438 miRNATAP -0.342286210060465 1.57145983452803e-07 NA NA NA hsa-miR-576-5p FGF12 -0.506413219377403 0.417187951364173 -0.0733567813264719 0.90082041524438 mirMAP -0.341959557719686 4.41549115389718e-05 NA NA NA hsa-miR-590-3p FGF12 -0.279244755376859 0.59126669933662 -0.0733567813264719 0.90082041524438 mirMAP -0.351420488091145 3.56594942426894e-07 NA NA NA hsa-miR-627-5p FGF12 -0.625000196758523 0.0876569242709129 -0.0733567813264719 0.90082041524438 MirTarget -0.248598270695446 1.94113453452336e-05 NA NA NA hsa-let-7a-3p FGF13 -0.215598045625677 0.85543299203799 0.520694054373788 0.23998224203533 MirTarget;miRNATAP -0.413074100574929 0.00107885043966615 NA NA NA hsa-let-7f-1-3p FGF13 -0.31101436822914 0.693407210545374 0.520694054373788 0.23998224203533 MirTarget -0.581948669375274 0.000736238594408478 NA NA NA hsa-let-7g-3p FGF13 -0.489638373791485 0.62941522205833 0.520694054373788 0.23998224203533 miRNATAP -0.33696694896657 0.000531004193754099 NA NA NA hsa-miR-141-3p FGF13 -0.31994058840327 0.87774106909065 0.520694054373788 0.23998224203533 TargetScan -0.417159688034008 1.38167745575151e-05 NA NA NA hsa-miR-142-5p FGF13 -0.118920788314118 0.929665277963083 0.520694054373788 0.23998224203533 PITA -0.292382680960941 0.00456041296807669 NA NA NA hsa-miR-200a-5p FGF13 -0.671005453811576 0.78126028567661 0.520694054373788 0.23998224203533 MirTarget;miRNATAP -0.564495834356228 3.51651879637505e-08 NA NA NA hsa-miR-200b-5p FGF13 -0.502275384207405 0.722255155236927 0.520694054373788 0.23998224203533 MirTarget -0.460602297876751 6.93130489630411e-06 NA NA NA hsa-miR-31-3p FGF13 0.199700996192121 0.762032341762692 0.520694054373788 0.23998224203533 miRNATAP -0.174024666919551 0.000702309408246688 NA NA NA hsa-miR-338-5p FGF13 0.484769112400393 0.393961930708873 0.520694054373788 0.23998224203533 PITA -0.36774029417946 7.03795092005192e-06 NA NA NA hsa-miR-429 FGF13 -0.456485631615963 0.806240953400535 0.520694054373788 0.23998224203533 miRNATAP -0.355487712048412 7.40384400340134e-05 NA NA NA hsa-miR-486-5p FGF13 -0.547739229538641 0.696404149927963 0.520694054373788 0.23998224203533 MirTarget;PITA;miRanda;miRNATAP -0.326993602223932 1.70539866789723e-05 NA NA NA hsa-miR-590-3p FGF13 -0.279244755376859 0.59126669933662 0.520694054373788 0.23998224203533 miRanda -0.459516353830251 9.69022571347246e-07 NA NA NA hsa-miR-7-1-3p FGF13 -0.462485777435991 0.665899751398166 0.520694054373788 0.23998224203533 MirTarget;mirMAP -0.56794497333139 2.1848177002488e-07 NA NA NA hsa-miR-362-3p FGF14 -0.721040238345347 0.0345881362485733 0.374536933825775 0.507146047810317 miRanda -0.430182537519489 0.000218513107489866 NA NA NA hsa-miR-421 FGF14 -0.182032017078616 0.734704500318599 0.374536933825775 0.507146047810317 miRanda -0.563420841003856 3.64961938596398e-05 NA NA NA hsa-miR-590-3p FGF14 -0.279244755376859 0.59126669933662 0.374536933825775 0.507146047810317 miRanda -0.820571422841574 7.63570407372503e-13 NA NA NA hsa-miR-96-5p FGF14 0.0854810872029343 0.923087820185031 0.374536933825775 0.507146047810317 TargetScan -0.651137820954271 6.59629769306502e-08 NA NA NA hsa-miR-107 FGF18 -0.0365118169251648 0.988364120226869 0.513929702717105 0.152144517947723 miRNATAP -0.44685632238394 0.00446346884872776 NA NA NA hsa-miR-15b-5p FGF18 -0.272614787130877 0.87096541832188 0.513929702717105 0.152144517947723 miRNATAP -0.345636147309442 0.00101388588722558 NA NA NA hsa-miR-330-5p FGF18 -0.283418953659271 0.815687101334695 0.513929702717105 0.152144517947723 PITA;miRanda;miRNATAP -0.337702816618645 0.00574604476925169 NA NA NA hsa-miR-590-3p FGF19 -0.279244755376859 0.59126669933662 2.93753615752985 0.000487871953382583 miRanda -0.570350872877377 0.00177520377476347 NA NA NA hsa-let-7a-3p FGF2 -0.215598045625677 0.85543299203799 0.0373403819942291 0.945663156310759 mirMAP -0.508812543963832 9.06476874891136e-06 NA NA NA hsa-let-7f-1-3p FGF2 -0.31101436822914 0.693407210545374 0.0373403819942291 0.945663156310759 mirMAP -0.898041596287031 5.55229359834088e-09 NA NA NA hsa-miR-103a-3p FGF2 -0.0763197091351717 0.980693102700275 0.0373403819942291 0.945663156310759 miRNAWalker2_validate;MirTarget;miRNATAP -0.555487766101954 0.000299387910834376 NA NA NA hsa-miR-107 FGF2 -0.0365118169251648 0.988364120226869 0.0373403819942291 0.945663156310759 MirTarget;PITA;miRanda;miRNATAP -0.666631439624559 0.000145161445434373 NA NA NA hsa-miR-1226-3p FGF2 -0.346825224699346 0.341199987121208 0.0373403819942291 0.945663156310759 MirTarget -0.426739098936905 2.27346551727714e-07 NA NA NA hsa-miR-126-5p FGF2 0.0815213541035824 0.956637332055185 0.0373403819942291 0.945663156310759 mirMAP -0.39861237255362 0.00311441679746807 NA NA NA hsa-miR-144-3p FGF2 0.0482420655617901 0.935871997593533 0.0373403819942291 0.945663156310759 MirTarget -0.185114796915547 0.00371893362650857 NA NA NA hsa-miR-146a-5p FGF2 -0.581292803346906 0.73685134936757 0.0373403819942291 0.945663156310759 mirMAP -0.239303659357824 0.00689738103130393 NA NA NA hsa-miR-148a-5p FGF2 -0.448099743845604 0.748419139652266 0.0373403819942291 0.945663156310759 mirMAP -0.643255342350378 1.37067115832144e-10 NA NA NA hsa-miR-15a-5p FGF2 -0.0674049094129128 0.964835434214123 0.0373403819942291 0.945663156310759 MirTarget;miRNATAP -0.810595460576908 2.34389020257957e-11 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 -0.557749208157585 0.609181305423188 0.0373403819942291 0.945663156310759 mirMAP -0.873695486287884 2.58254499447684e-18 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 -0.272614787130877 0.87096541832188 0.0373403819942291 0.945663156310759 MirTarget;miRNATAP -0.632114726323833 4.74427142629327e-08 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 0.151694812889216 0.733736501874638 0.0373403819942291 0.945663156310759 mirMAP -0.595329456522208 1.85904394592668e-11 NA NA NA hsa-miR-16-2-3p FGF2 -0.36717860153421 0.546850726070016 0.0373403819942291 0.945663156310759 mirMAP -0.676110107115778 1.38872264287738e-13 NA NA NA hsa-miR-16-5p FGF2 0.0135949734723564 0.994476223855607 0.0373403819942291 0.945663156310759 miRNAWalker2_validate;MirTarget;miRNATAP -0.781119741978123 5.08790173078263e-12 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-186-5p FGF2 -0.318786974828757 0.85412722938961 0.0373403819942291 0.945663156310759 miRNAWalker2_validate;mirMAP -1.1396095411898 1.32095654595195e-16 NA NA NA hsa-miR-192-5p FGF2 -0.117345487848223 0.972927287653137 0.0373403819942291 0.945663156310759 miRNAWalker2_validate -0.660983463822095 1.1746446867625e-17 NA NA NA hsa-miR-19b-1-5p FGF2 -0.0105982583216702 0.988511655226679 0.0373403819942291 0.945663156310759 mirMAP -0.6699845320046 3.36056715432067e-13 NA NA NA hsa-miR-200b-3p FGF2 -0.426401948379212 0.863957108574195 0.0373403819942291 0.945663156310759 mirMAP -0.764037256793823 2.14808621340383e-15 NA NA NA hsa-miR-200c-3p FGF2 -0.437282635857873 0.887118598436407 0.0373403819942291 0.945663156310759 mirMAP -0.707152104708369 2.07242913334904e-12 NA NA NA hsa-miR-20a-3p FGF2 0.456808229166028 0.57674056136504 0.0373403819942291 0.945663156310759 mirMAP -0.565021759285698 1.65191743671975e-16 NA NA NA hsa-miR-21-3p FGF2 -0.395016549347053 0.87819982773565 0.0373403819942291 0.945663156310759 mirMAP -0.525887720334036 2.03384873578629e-05 NA NA NA hsa-miR-215-5p FGF2 -0.142648109361913 0.94480931294964 0.0373403819942291 0.945663156310759 miRNAWalker2_validate -0.1996191442956 0.000148824005851472 NA NA NA hsa-miR-221-3p FGF2 0.0906940388127513 0.959121118272534 0.0373403819942291 0.945663156310759 mirMAP -0.511851720649979 6.5981563407402e-05 NA NA NA hsa-miR-222-3p FGF2 -0.0265849318772702 0.984005474689108 0.0373403819942291 0.945663156310759 mirMAP -0.553734986991286 1.13582430859507e-06 NA NA NA hsa-miR-29a-5p FGF2 -0.31835175571979 0.600442757817281 0.0373403819942291 0.945663156310759 mirMAP -0.742375002118135 1.13325741058218e-16 NA NA NA hsa-miR-32-5p FGF2 -0.05993267619119 0.952975951594959 0.0373403819942291 0.945663156310759 miRNAWalker2_validate -0.754687420738596 5.83016327813086e-15 NA NA NA hsa-miR-335-3p FGF2 -0.244830745789445 0.88450019116631 0.0373403819942291 0.945663156310759 mirMAP -0.623112924854523 1.0815869667606e-11 NA NA NA hsa-miR-335-5p FGF2 -0.0284895175847679 0.973380867832231 0.0373403819942291 0.945663156310759 miRNATAP -0.536967962946236 9.06296636807829e-09 NA NA NA hsa-miR-361-5p FGF2 -0.138735309928775 0.941495130308343 0.0373403819942291 0.945663156310759 mirMAP -0.78695237917696 7.1578087398883e-06 NA NA NA hsa-miR-374a-3p FGF2 -0.118320910531011 0.958176637009264 0.0373403819942291 0.945663156310759 mirMAP -0.405589678990389 9.7090927181742e-05 NA NA NA hsa-miR-374a-5p FGF2 -0.343007247142618 0.766921280269271 0.0373403819942291 0.945663156310759 mirMAP -0.615897614224652 3.39071246093852e-05 NA NA NA hsa-miR-374b-5p FGF2 -0.285682091626878 0.83569830479965 0.0373403819942291 0.945663156310759 mirMAP -0.63693950869037 9.22970111909352e-06 NA NA NA hsa-miR-424-5p FGF2 0.247080963500746 0.870154571783568 0.0373403819942291 0.945663156310759 MirTarget;miRNATAP -0.317186554824623 0.000274243410436879 NA NA NA hsa-miR-429 FGF2 -0.456485631615963 0.806240953400535 0.0373403819942291 0.945663156310759 mirMAP -0.659250932855199 1.3145598381986e-17 NA NA NA hsa-miR-450b-5p FGF2 -0.0136687538973108 0.983149761399849 0.0373403819942291 0.945663156310759 mirMAP -0.376394927184003 0.000544626699489289 NA NA NA hsa-miR-452-5p FGF2 -0.0504626418153507 0.973874641360401 0.0373403819942291 0.945663156310759 mirMAP -0.316774722550962 0.00166338629734726 NA NA NA hsa-miR-503-5p FGF2 0.181411121123657 0.766398160421164 0.0373403819942291 0.945663156310759 miRNAWalker2_validate -0.242112168267636 0.00115555825657166 NA NA NA hsa-miR-548o-3p FGF2 -0.191447572716994 0.517725546183501 0.0373403819942291 0.945663156310759 mirMAP -0.405276201885792 1.87951720405162e-05 NA NA NA hsa-miR-577 FGF2 -1.06238199218774 0.326056761787754 0.0373403819942291 0.945663156310759 mirMAP -0.418499733893086 2.48828015960997e-16 NA NA NA hsa-miR-589-3p FGF2 -0.835836305204965 0.0112001563801511 0.0373403819942291 0.945663156310759 mirMAP -0.469403508103215 2.93831023020729e-09 NA NA NA hsa-miR-590-3p FGF2 -0.279244755376859 0.59126669933662 0.0373403819942291 0.945663156310759 miRanda;mirMAP -0.580439028713546 4.11374953518771e-12 NA NA NA hsa-miR-590-5p FGF2 -0.547819833829572 0.472735645776647 0.0373403819942291 0.945663156310759 miRanda;mirMAP -0.776292987315148 8.39227453533076e-20 NA NA NA hsa-miR-92a-3p FGF2 0.0278830870766349 0.993247426671713 0.0373403819942291 0.945663156310759 miRNAWalker2_validate -0.727257700170323 1.67908806653227e-12 NA NA NA hsa-miR-93-3p FGF2 -0.438355548962673 0.549902689385444 0.0373403819942291 0.945663156310759 mirMAP -0.765339743128867 1.06748038330992e-15 NA NA NA hsa-let-7a-3p FGF7 -0.215598045625677 0.85543299203799 0.117105484614997 0.84810083077581 MirTarget;miRNATAP -0.683797140192053 9.84850919759302e-09 NA NA NA hsa-let-7f-1-3p FGF7 -0.31101436822914 0.693407210545374 0.117105484614997 0.84810083077581 MirTarget -1.01161889577803 3.96642337308699e-10 NA NA NA hsa-miR-107 FGF7 -0.0365118169251648 0.988364120226869 0.117105484614997 0.84810083077581 PITA;miRanda;miRNATAP -0.735310081307788 7.03519067269405e-05 NA NA NA hsa-miR-15a-5p FGF7 -0.0674049094129128 0.964835434214123 0.117105484614997 0.84810083077581 miRTarBase;miRNATAP -0.915215726654164 5.87256834931938e-13 NA NA NA hsa-miR-15b-5p FGF7 -0.272614787130877 0.87096541832188 0.117105484614997 0.84810083077581 miRNATAP -0.898118902123496 3.56849030030929e-14 NA NA NA hsa-miR-16-1-3p FGF7 0.151694812889216 0.733736501874638 0.117105484614997 0.84810083077581 mirMAP -0.658002745075143 1.56217551778173e-12 NA NA NA hsa-miR-16-2-3p FGF7 -0.36717860153421 0.546850726070016 0.117105484614997 0.84810083077581 mirMAP -0.841611831563134 3.02322699081552e-19 NA NA NA hsa-miR-16-5p FGF7 0.0135949734723564 0.994476223855607 0.117105484614997 0.84810083077581 miRNATAP -0.996043180010876 9.83296454189259e-18 NA NA NA hsa-miR-18a-3p FGF7 -0.270443061178857 0.535291623032886 0.117105484614997 0.84810083077581 MirTarget -0.452090132240855 7.63312718888582e-09 NA NA NA hsa-miR-192-3p FGF7 -0.182835023264086 0.910241598161436 0.117105484614997 0.84810083077581 mirMAP -0.730591279287558 7.23835865583408e-16 NA NA NA hsa-miR-20a-5p FGF7 -0.179153323927949 0.928118119139752 0.117105484614997 0.84810083077581 miRNAWalker2_validate -0.671805814937027 1.227742024366e-13 NA NA NA hsa-miR-26b-5p FGF7 -0.0245931278499594 0.990377966314923 0.117105484614997 0.84810083077581 mirMAP -0.994759587889311 1.98671841899925e-12 NA NA NA hsa-miR-27a-3p FGF7 -0.123902317731458 0.958804393510999 0.117105484614997 0.84810083077581 MirTarget -0.79784830342047 5.00354716971529e-06 NA NA NA hsa-miR-30d-3p FGF7 -0.123474741320298 0.814905367625791 0.117105484614997 0.84810083077581 miRNATAP -0.848677643180664 4.97187104853254e-13 NA NA NA hsa-miR-31-5p FGF7 0.554749187802405 0.452741448126019 0.117105484614997 0.84810083077581 MirTarget -0.12713264127766 0.00816156313575643 NA NA NA hsa-miR-320a FGF7 -0.416546433767628 0.840202138616422 0.117105484614997 0.84810083077581 miRanda -0.38477547966865 0.00354239940076227 NA NA NA hsa-miR-33a-3p FGF7 -0.794543849238581 0.0105203072007922 0.117105484614997 0.84810083077581 mirMAP -0.569137001117195 3.2142782858291e-10 NA NA NA hsa-miR-361-5p FGF7 -0.138735309928775 0.941495130308343 0.117105484614997 0.84810083077581 PITA;miRanda;miRNATAP -0.817249024356749 1.02535422069167e-05 NA NA NA hsa-miR-374a-3p FGF7 -0.118320910531011 0.958176637009264 0.117105484614997 0.84810083077581 miRNATAP -0.461888146139023 2.48354867802797e-05 NA NA NA hsa-miR-376b-3p FGF7 -0.00712550627858333 0.982426403308526 0.117105484614997 0.84810083077581 mirMAP -0.25669480427003 0.00740387863393709 NA NA NA hsa-miR-421 FGF7 -0.182032017078616 0.734704500318599 0.117105484614997 0.84810083077581 miRanda -0.482726608710923 3.82945596931546e-06 NA NA NA hsa-miR-424-5p FGF7 0.247080963500746 0.870154571783568 0.117105484614997 0.84810083077581 miRNATAP -0.323271584602368 0.000450740900959982 NA NA NA hsa-miR-429 FGF7 -0.456485631615963 0.806240953400535 0.117105484614997 0.84810083077581 miRNATAP -0.774285251391027 2.36438990639667e-22 NA NA NA hsa-miR-455-3p FGF7 -0.356341681711462 0.824635754440661 0.117105484614997 0.84810083077581 PITA;miRNATAP -0.48338226161898 1.06435583592578e-07 NA NA NA hsa-miR-484 FGF7 -0.179977202691249 0.886333755572375 0.117105484614997 0.84810083077581 PITA -0.782625541153355 5.9522288202395e-09 NA NA NA hsa-miR-501-5p FGF7 -0.834032628506285 0.0582725160418523 0.117105484614997 0.84810083077581 PITA;mirMAP -0.341715472671014 2.71246634460809e-05 NA NA NA hsa-miR-577 FGF7 -1.06238199218774 0.326056761787754 0.117105484614997 0.84810083077581 PITA;mirMAP -0.491874797413476 1.17833120646792e-20 NA NA NA hsa-miR-582-3p FGF7 -0.2334649592375 0.897678119160318 0.117105484614997 0.84810083077581 PITA;miRNATAP -0.603474572580205 9.9286156151158e-08 NA NA NA hsa-miR-590-3p FGF7 -0.279244755376859 0.59126669933662 0.117105484614997 0.84810083077581 PITA;miRanda;mirMAP;miRNATAP -0.749830093913929 2.12386794213734e-18 NA NA NA hsa-miR-590-5p FGF7 -0.547819833829572 0.472735645776647 0.117105484614997 0.84810083077581 PITA;miRanda -0.83329719340048 1.49190340527621e-20 NA NA NA hsa-miR-7-1-3p FGF7 -0.462485777435991 0.665899751398166 0.117105484614997 0.84810083077581 mirMAP -0.8693351687903 5.61446758918235e-18 NA NA NA hsa-miR-16-2-3p FGF9 -0.36717860153421 0.546850726070016 1.14029297978378 0.0641126010099636 mirMAP -0.393378730749977 0.00280520232673893 NA NA NA hsa-miR-32-3p FGF9 -0.568003960723004 0.13133163420273 1.14029297978378 0.0641126010099636 mirMAP -0.350559608669684 0.000700563991493217 NA NA NA hsa-miR-369-3p FGF9 0.116576891957687 0.83230082995912 1.14029297978378 0.0641126010099636 mirMAP;miRNATAP -0.385648033163106 0.00880290404065266 NA NA NA hsa-miR-582-5p FGF9 -0.399450205475138 0.581227478860085 1.14029297978378 0.0641126010099636 miRNATAP -0.404187233255667 0.00944896090587376 NA NA NA hsa-miR-590-3p FGF9 -0.279244755376859 0.59126669933662 1.14029297978378 0.0641126010099636 miRanda;mirMAP -0.395821562370221 0.000917959517750086 NA NA NA hsa-miR-590-5p FGF9 -0.547819833829572 0.472735645776647 1.14029297978378 0.0641126010099636 miRanda -0.412960170102671 0.00107892101454606 NA NA NA hsa-miR-106a-5p FGFR1 -0.203919267842652 0.802213958426804 0.201596157808259 0.858976102109112 mirMAP -0.541320037319434 1.27089321486615e-11 NA NA NA hsa-miR-106b-5p FGFR1 -0.297128724729339 0.869294443540749 0.201596157808259 0.858976102109112 mirMAP -0.822036581006192 1.74218158243198e-20 NA NA NA hsa-miR-10a-5p FGFR1 0.0740585720685925 0.983770933356406 0.201596157808259 0.858976102109112 miRNAWalker2_validate -0.427574241021871 5.41836198534693e-08 21738581 Predicted target mRNAs FGFR1 miR-10 and MLH1 miR-155 were found downregulated pancreatic cancer hsa-miR-1262 FGFR1 -0.110067426706709 0.702946442225154 0.201596157808259 0.858976102109112 miRNATAP -0.251289067000032 0.00148412321886111 NA NA NA hsa-miR-135b-5p FGFR1 0.631573976263484 0.610028066417462 0.201596157808259 0.858976102109112 mirMAP -0.282955130702862 1.46105054047634e-08 NA NA NA hsa-miR-15a-5p FGFR1 -0.0674049094129128 0.964835434214123 0.201596157808259 0.858976102109112 miRNATAP -0.697884650841183 4.50635824486199e-13 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGFR1 -0.272614787130877 0.87096541832188 0.201596157808259 0.858976102109112 miRNATAP -0.587016769958609 1.49522035399957e-10 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 0.0135949734723564 0.994476223855607 0.201596157808259 0.858976102109112 miRTarBase;miRNATAP -0.710035294277253 1.6547310603001e-15 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 -0.175448849583061 0.934544015912731 0.201596157808259 0.858976102109112 mirMAP -0.610985080987738 2.23569876237106e-19 NA NA NA hsa-miR-200a-5p FGFR1 -0.671005453811576 0.78126028567661 0.201596157808259 0.858976102109112 mirMAP -0.556564764968645 2.34312674404821e-14 NA NA NA hsa-miR-200b-5p FGFR1 -0.502275384207405 0.722255155236927 0.201596157808259 0.858976102109112 mirMAP -0.636495015609043 1.43412507645059e-19 NA NA NA hsa-miR-20a-5p FGFR1 -0.179153323927949 0.928118119139752 0.201596157808259 0.858976102109112 mirMAP -0.548264098344271 7.83526634355048e-16 NA NA NA hsa-miR-301a-3p FGFR1 -0.105312511901769 0.831686745977347 0.201596157808259 0.858976102109112 mirMAP -0.315204588952987 1.26823479410232e-05 NA NA NA hsa-miR-335-3p FGFR1 -0.244830745789445 0.88450019116631 0.201596157808259 0.858976102109112 mirMAP -0.575295661556483 1.48474905901463e-15 NA NA NA hsa-miR-361-5p FGFR1 -0.138735309928775 0.941495130308343 0.201596157808259 0.858976102109112 miRanda -0.700504879479453 5.36006547735018e-07 NA NA NA hsa-miR-424-5p FGFR1 0.247080963500746 0.870154571783568 0.201596157808259 0.858976102109112 miRNAWalker2_validate;miRTarBase;miRNATAP -0.209822150049386 0.00280762955990033 NA NA NA hsa-miR-532-5p FGFR1 -0.349665553500088 0.878948352437467 0.201596157808259 0.858976102109112 PITA -0.594965040936966 7.97089485362319e-14 NA NA NA hsa-miR-548o-3p FGFR1 -0.191447572716994 0.517725546183501 0.201596157808259 0.858976102109112 mirMAP -0.315700053957701 3.27962049891296e-05 NA NA NA hsa-miR-577 FGFR1 -1.06238199218774 0.326056761787754 0.201596157808259 0.858976102109112 PITA;mirMAP -0.325574779163253 2.46595601408019e-15 NA NA NA hsa-miR-590-3p FGFR1 -0.279244755376859 0.59126669933662 0.201596157808259 0.858976102109112 miRanda;mirMAP -0.519217394538685 4.04575525965042e-15 NA NA NA hsa-miR-93-5p FGFR1 -0.611073677204699 0.825297877093193 0.201596157808259 0.858976102109112 mirMAP -0.666292245954266 1.03850684119196e-14 NA NA NA hsa-miR-188-5p FGFR2 -0.568517670542551 0.324820848307954 -0.37581671975967 0.688774968722175 PITA -0.411925402857108 4.09722691497335e-06 NA NA NA hsa-miR-19b-1-5p FGFR2 -0.0105982583216702 0.988511655226679 -0.37581671975967 0.688774968722175 miRNAWalker2_validate;miRTarBase -0.474383008962662 2.29712590167021e-05 NA NA NA hsa-miR-369-3p FGFR2 0.116576891957687 0.83230082995912 -0.37581671975967 0.688774968722175 miRNATAP -0.32556688552856 0.00975076567041639 NA NA NA hsa-miR-542-3p FGFR2 0.188168046511374 0.909252939431573 -0.37581671975967 0.688774968722175 miRanda -0.720387475259984 9.01022691363113e-07 NA NA NA hsa-miR-940 FGFR2 -0.225788347550697 0.680055767105815 -0.37581671975967 0.688774968722175 miRNATAP -0.270065978012755 0.00207802989445929 NA NA NA hsa-miR-106a-5p FLT1 -0.203919267842652 0.802213958426804 0.335459881337518 0.769646686410767 MirTarget;miRNATAP -0.217932050508775 7.42586014642432e-05 NA NA NA hsa-miR-106b-5p FLT1 -0.297128724729339 0.869294443540749 0.335459881337518 0.769646686410767 MirTarget;miRNATAP -0.362342015309591 6.44034105699633e-09 NA NA NA hsa-miR-10a-5p FLT1 0.0740585720685925 0.983770933356406 0.335459881337518 0.769646686410767 miRNATAP -0.188059072473371 0.000422135661220862 NA NA NA hsa-miR-149-5p FLT1 -0.0341785025317569 0.961061088204977 0.335459881337518 0.769646686410767 MirTarget -0.157900287345921 0.000368536021817626 NA NA NA hsa-miR-17-5p FLT1 -0.175448849583061 0.934544015912731 0.335459881337518 0.769646686410767 MirTarget;TargetScan;miRNATAP -0.232312640570346 1.37730704537759e-06 NA NA NA hsa-miR-181b-5p FLT1 0.155313039554487 0.930176779696506 0.335459881337518 0.769646686410767 miRNATAP -0.187653050926259 0.0044509288988792 NA NA NA hsa-miR-186-5p FLT1 -0.318786974828757 0.85412722938961 0.335459881337518 0.769646686410767 mirMAP -0.270733774321563 0.000537584221831587 NA NA NA hsa-miR-19a-3p FLT1 -0.206793507801887 0.844637784802316 0.335459881337518 0.769646686410767 MirTarget -0.190391787064455 3.58230909213624e-05 NA NA NA hsa-miR-19b-3p FLT1 -0.0268530183621474 0.986656783046572 0.335459881337518 0.769646686410767 MirTarget -0.223701499996085 4.97311863992031e-05 NA NA NA hsa-miR-200b-3p FLT1 -0.426401948379212 0.863957108574195 0.335459881337518 0.769646686410767 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.266841639122542 6.33604980248532e-07 21115742 Forced miR-200 expression suppressed Flt1 levels in metastasis-prone lung adenocarcinoma cells derived from K-ras/p53-mutant mice and negatively regulated the Flt1 3'-UTR in reporter assays; We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1 metastasis;tumorigenesis lung cancer hsa-miR-200c-3p FLT1 -0.437282635857873 0.887118598436407 0.335459881337518 0.769646686410767 miRNAWalker2_validate;miRTarBase;MirTarget -0.228126738051025 4.1207149994109e-05 NA NA NA hsa-miR-20a-5p FLT1 -0.179153323927949 0.928118119139752 0.335459881337518 0.769646686410767 MirTarget;miRNATAP -0.184216066996964 0.00011858416873161 NA NA NA hsa-miR-24-3p FLT1 -0.0484778924256624 0.985274054814493 0.335459881337518 0.769646686410767 miRNATAP -0.369737504231116 0.000985929131493309 NA NA NA hsa-miR-29a-5p FLT1 -0.31835175571979 0.600442757817281 0.335459881337518 0.769646686410767 MirTarget -0.25426638977066 3.81343086893255e-07 NA NA NA hsa-miR-335-3p FLT1 -0.244830745789445 0.88450019116631 0.335459881337518 0.769646686410767 mirMAP -0.19625230682989 0.000106198318564869 NA NA NA hsa-miR-339-5p FLT1 -0.300425087100667 0.712912847076788 0.335459881337518 0.769646686410767 miRanda -0.311508333463944 1.01479232416928e-12 NA NA NA hsa-miR-369-3p FLT1 0.116576891957687 0.83230082995912 0.335459881337518 0.769646686410767 MirTarget;miRNATAP -0.185436249137413 0.00117046477437708 NA NA NA hsa-miR-429 FLT1 -0.456485631615963 0.806240953400535 0.335459881337518 0.769646686410767 MirTarget;miRanda;miRNATAP -0.239587491657242 2.72032013728119e-08 NA NA NA hsa-miR-491-3p FLT1 -0.513850326596847 0.137836285146052 0.335459881337518 0.769646686410767 miRNATAP -0.177120471645147 0.000140749730219656 NA NA NA hsa-miR-501-5p FLT1 -0.834032628506285 0.0582725160418523 0.335459881337518 0.769646686410767 mirMAP -0.160650412318997 9.80457640413844e-05 NA NA NA hsa-miR-505-5p FLT1 -0.555858818875454 0.317679205488749 0.335459881337518 0.769646686410767 MirTarget -0.171852611824984 0.00192107890591474 NA NA NA hsa-miR-576-5p FLT1 -0.506413219377403 0.417187951364173 0.335459881337518 0.769646686410767 mirMAP -0.178014369696481 0.00145222641220755 NA NA NA hsa-miR-590-3p FLT1 -0.279244755376859 0.59126669933662 0.335459881337518 0.769646686410767 miRanda -0.268266566181388 3.15956947898578e-09 NA NA NA hsa-miR-629-3p FLT1 -0.495402745812008 0.333967382214384 0.335459881337518 0.769646686410767 MirTarget -0.201236032594846 5.44570231226212e-06 NA NA NA hsa-miR-93-5p FLT1 -0.611073677204699 0.825297877093193 0.335459881337518 0.769646686410767 MirTarget;miRNATAP -0.288708238581385 1.30917423548279e-06 NA NA NA hsa-miR-335-5p FLT3 -0.0284895175847679 0.973380867832231 -0.582760672328199 0.454037354535359 miRNAWalker2_validate -0.559024463620852 2.59362128018203e-06 NA NA NA hsa-miR-590-3p FLT3 -0.279244755376859 0.59126669933662 -0.582760672328199 0.454037354535359 PITA;miRanda;mirMAP;miRNATAP -0.397131408453822 0.0002854017762368 NA NA NA hsa-miR-194-3p FLT4 -0.614465699221301 0.733214497063146 0.429953978262657 0.515812907628149 mirMAP -0.438107995800777 7.41811467585558e-14 NA NA NA hsa-miR-331-3p FLT4 -0.40204226129616 0.670588911553669 0.429953978262657 0.515812907628149 miRNAWalker2_validate -0.401841710981882 3.49815729282156e-07 NA NA NA hsa-miR-374a-5p FLT4 -0.343007247142618 0.766921280269271 0.429953978262657 0.515812907628149 mirMAP -0.385992088793107 0.000289488700189213 NA NA NA hsa-miR-374b-5p FLT4 -0.285682091626878 0.83569830479965 0.429953978262657 0.515812907628149 mirMAP -0.522619192236735 2.77352074366153e-07 NA NA NA hsa-miR-429 FLT4 -0.456485631615963 0.806240953400535 0.429953978262657 0.515812907628149 miRanda;miRNATAP -0.416385057079148 1.21614490885909e-13 NA NA NA hsa-miR-128-3p FOXO4 -0.442192625156042 0.783886533572187 -0.022431348880156 0.983752751063808 MirTarget -0.175602585351802 0.00208058193623921 NA NA NA hsa-miR-126-5p GAB1 0.0815213541035824 0.956637332055185 -0.169955579687024 0.874132585899831 mirMAP -0.141880047745241 0.00318182528022064 NA NA NA hsa-miR-142-3p GAB1 -0.154235241441331 0.946098054588918 -0.169955579687024 0.874132585899831 MirTarget;PITA;miRanda;miRNATAP -0.141172396337228 2.76805922777564e-06 NA NA NA hsa-miR-142-5p GAB1 -0.118920788314118 0.929665277963083 -0.169955579687024 0.874132585899831 MirTarget -0.151473072776408 5.11877593057492e-06 NA NA NA hsa-miR-212-3p GAB1 -0.0224067199236484 0.973232008101458 -0.169955579687024 0.874132585899831 mirMAP -0.173644510154527 0.000156975666522172 NA NA NA hsa-miR-221-3p GAB1 0.0906940388127513 0.959121118272534 -0.169955579687024 0.874132585899831 MirTarget;miRNATAP -0.141292220683357 0.00217591213532496 NA NA NA hsa-miR-222-3p GAB1 -0.0265849318772702 0.984005474689108 -0.169955579687024 0.874132585899831 MirTarget;miRNATAP -0.145583600728172 0.000397142580052132 NA NA NA hsa-miR-223-5p GAB1 -0.240875559833371 0.63718452766414 -0.169955579687024 0.874132585899831 mirMAP -0.157403230440576 2.55103713715747e-08 NA NA NA hsa-miR-330-5p GAB1 -0.283418953659271 0.815687101334695 -0.169955579687024 0.874132585899831 PITA;miRanda;miRNATAP -0.172796075062996 0.000396180138218106 NA NA NA hsa-miR-421 GAB2 -0.182032017078616 0.734704500318599 0.00389085345802975 0.997417209656585 miRanda -0.11990126654531 0.00386351085342639 NA NA NA hsa-miR-98-5p GAB2 -0.168162186023221 0.898802461503524 0.00389085345802975 0.997417209656585 MirTarget -0.156851864443786 0.00771071824063459 NA NA NA hsa-let-7a-3p GNB4 -0.215598045625677 0.85543299203799 0.150575910970852 0.870906281992549 MirTarget -0.527462288702162 1.32800230080668e-10 NA NA NA hsa-let-7f-1-3p GNB4 -0.31101436822914 0.693407210545374 0.150575910970852 0.870906281992549 MirTarget -0.725850164098216 9.21270487377611e-11 NA NA NA hsa-miR-126-5p GNB4 0.0815213541035824 0.956637332055185 0.150575910970852 0.870906281992549 mirMAP -0.296092228762981 0.00275698662241744 NA NA NA hsa-miR-1275 GNB4 -0.831342050607648 0.0803795852164229 0.150575910970852 0.870906281992549 MirTarget -0.256794511297655 5.71810884593168e-08 NA NA NA hsa-miR-16-2-3p GNB4 -0.36717860153421 0.546850726070016 0.150575910970852 0.870906281992549 mirMAP -0.551716333089633 6.00467816630765e-17 NA NA NA hsa-miR-186-5p GNB4 -0.318786974828757 0.85412722938961 0.150575910970852 0.870906281992549 MirTarget -0.689383409225049 3.1268492590221e-11 NA NA NA hsa-miR-203a-3p GNB4 -0.265248086637561 0.931593594361942 0.150575910970852 0.870906281992549 MirTarget -0.372281855373237 1.22670796920165e-11 NA NA NA hsa-miR-21-3p GNB4 -0.395016549347053 0.87819982773565 0.150575910970852 0.870906281992549 MirTarget -0.427995528370939 2.0332855968286e-06 NA NA NA hsa-miR-23a-3p GNB4 -0.122198715333656 0.962717452143511 0.150575910970852 0.870906281992549 mirMAP -0.472738699668562 0.000893155145884879 NA NA NA hsa-miR-27b-3p GNB4 -0.14277121795778 0.951937409841932 0.150575910970852 0.870906281992549 miRNAWalker2_validate -0.435880720226156 0.00204920933249677 NA NA NA hsa-miR-29a-3p GNB4 0.01127474410284 0.996977020481272 0.150575910970852 0.870906281992549 MirTarget -0.743368974633575 6.34983117847608e-15 NA NA NA hsa-miR-29b-3p GNB4 -0.104016192263954 0.958988036765397 0.150575910970852 0.870906281992549 MirTarget -0.61243623995895 7.63823968895368e-18 NA NA NA hsa-miR-33a-3p GNB4 -0.794543849238581 0.0105203072007922 0.150575910970852 0.870906281992549 MirTarget -0.403517140225735 1.29024852258078e-10 NA NA NA hsa-miR-361-5p GNB4 -0.138735309928775 0.941495130308343 0.150575910970852 0.870906281992549 miRanda;miRNATAP -0.571025704918098 9.11850229661736e-06 NA NA NA hsa-miR-376a-5p GNB4 0.0978680856849549 0.773217338913054 0.150575910970852 0.870906281992549 MirTarget -0.231791319804353 0.000534543494369469 NA NA NA hsa-miR-429 GNB4 -0.456485631615963 0.806240953400535 0.150575910970852 0.870906281992549 miRanda -0.521698904248221 8.01914817356433e-21 NA NA NA hsa-miR-452-5p GNB4 -0.0504626418153507 0.973874641360401 0.150575910970852 0.870906281992549 MirTarget -0.254078324559164 0.00057043017429811 NA NA NA hsa-miR-501-5p GNB4 -0.834032628506285 0.0582725160418523 0.150575910970852 0.870906281992549 mirMAP -0.259427355324393 4.16228772969499e-06 NA NA NA hsa-miR-548o-3p GNB4 -0.191447572716994 0.517725546183501 0.150575910970852 0.870906281992549 MirTarget -0.255354766069344 0.000258360441062798 NA NA NA hsa-miR-582-5p GNB4 -0.399450205475138 0.581227478860085 0.150575910970852 0.870906281992549 MirTarget -0.304596682684376 0.00023676420891946 NA NA NA hsa-miR-590-3p GNB4 -0.279244755376859 0.59126669933662 0.150575910970852 0.870906281992549 MirTarget;miRanda -0.481731712009225 1.49322647046165e-15 NA NA NA hsa-miR-7-1-3p GNB4 -0.462485777435991 0.665899751398166 0.150575910970852 0.870906281992549 MirTarget -0.488446835457065 1.29243217525554e-11 NA NA NA hsa-miR-877-5p GNB4 -0.317720731672575 0.435952264022643 0.150575910970852 0.870906281992549 MirTarget -0.275485690829795 5.55278046948466e-07 NA NA NA hsa-miR-93-5p GNB4 -0.611073677204699 0.825297877093193 0.150575910970852 0.870906281992549 miRNAWalker2_validate -0.570655068620063 7.46595886693956e-13 NA NA NA hsa-miR-96-5p GNB4 0.0854810872029343 0.923087820185031 0.150575910970852 0.870906281992549 MirTarget -0.508627119875564 1.77027482987553e-16 NA NA NA hsa-miR-128-3p GNB5 -0.442192625156042 0.783886533572187 -0.0649528135314408 0.938218455897553 miRNAWalker2_validate -0.275817735059449 0.000230287213313501 NA NA NA hsa-miR-130b-3p GNB5 -0.221667315324818 0.824660172394714 -0.0649528135314408 0.938218455897553 miRNAWalker2_validate -0.273482376291113 4.037374696104e-06 NA NA NA hsa-miR-148a-3p GNB5 -0.101286586375016 0.976980454193186 -0.0649528135314408 0.938218455897553 miRNAWalker2_validate -0.383298605115451 3.0389598343895e-11 NA NA NA hsa-miR-17-5p GNB5 -0.175448849583061 0.934544015912731 -0.0649528135314408 0.938218455897553 TargetScan -0.356805592068732 2.12915653285483e-13 NA NA NA hsa-miR-26b-5p GNB5 -0.0245931278499594 0.990377966314923 -0.0649528135314408 0.938218455897553 miRNAWalker2_validate -0.299348321837633 0.000113963512166663 NA NA NA hsa-miR-27a-3p GNB5 -0.123902317731458 0.958804393510999 -0.0649528135314408 0.938218455897553 miRNAWalker2_validate -0.374667661574724 5.34111755135333e-05 NA NA NA hsa-miR-361-5p GNB5 -0.138735309928775 0.941495130308343 -0.0649528135314408 0.938218455897553 miRanda -0.426377614029263 1.31175910214088e-05 NA NA NA hsa-miR-425-5p GNB5 -0.354606074344121 0.845979106734409 -0.0649528135314408 0.938218455897553 miRNAWalker2_validate -0.286665566892633 4.13300378904745e-08 NA NA NA hsa-miR-429 GNB5 -0.456485631615963 0.806240953400535 -0.0649528135314408 0.938218455897553 miRanda -0.33677300920156 1.19834345545659e-14 NA NA NA hsa-miR-452-3p GNB5 -0.167134177977311 0.799008246175244 -0.0649528135314408 0.938218455897553 mirMAP -0.225516801818803 2.3903738192163e-08 NA NA NA hsa-miR-590-3p GNB5 -0.279244755376859 0.59126669933662 -0.0649528135314408 0.938218455897553 miRanda -0.140750566851599 0.00391178630566149 NA NA NA hsa-miR-126-5p GNG12 0.0815213541035824 0.956637332055185 -0.142668426794612 0.929391620324368 mirMAP -0.185177316145845 0.000122141017476559 NA NA NA hsa-miR-409-5p GNG12 0.114137352474602 0.862758126973031 -0.142668426794612 0.929391620324368 PITA -0.110560226623452 0.000614581063746225 NA NA NA hsa-miR-455-5p GNG12 -0.139599153671262 0.865744220236311 -0.142668426794612 0.929391620324368 miRanda -0.123706173617567 0.00119377079445104 NA NA NA hsa-miR-23a-3p GNG2 -0.122198715333656 0.962717452143511 0.0195340430449504 0.979278777912881 miRNATAP -0.586749326631971 1.18805552862352e-06 NA NA NA hsa-miR-29a-3p GNG2 0.01127474410284 0.996977020481272 0.0195340430449504 0.979278777912881 miRNATAP -0.521964008408501 5.4920831631013e-10 NA NA NA hsa-miR-29b-3p GNG2 -0.104016192263954 0.958988036765397 0.0195340430449504 0.979278777912881 miRNATAP -0.464301471964614 1.15162439366794e-13 NA NA NA hsa-miR-30d-3p GNG2 -0.123474741320298 0.814905367625791 0.0195340430449504 0.979278777912881 mirMAP -0.432540716773994 1.44634964537532e-09 NA NA NA hsa-miR-324-5p GNG2 -0.50063248413014 0.537416710557032 0.0195340430449504 0.979278777912881 miRanda -0.366129018316216 8.00496961037959e-08 NA NA NA hsa-miR-335-3p GNG2 -0.244830745789445 0.88450019116631 0.0195340430449504 0.979278777912881 mirMAP -0.405349421816321 2.19102607784949e-12 NA NA NA hsa-miR-429 GNG2 -0.456485631615963 0.806240953400535 0.0195340430449504 0.979278777912881 miRanda;miRNATAP -0.373755953883467 4.98629894373416e-14 NA NA NA hsa-miR-500a-5p GNG2 -0.71978560736831 0.188073776225276 0.0195340430449504 0.979278777912881 mirMAP -0.357661536606533 5.12404737407786e-11 NA NA NA hsa-miR-576-5p GNG2 -0.506413219377403 0.417187951364173 0.0195340430449504 0.979278777912881 mirMAP -0.329879268691927 3.99552599442828e-07 NA NA NA hsa-miR-577 GNG2 -1.06238199218774 0.326056761787754 0.0195340430449504 0.979278777912881 PITA;miRNATAP -0.211919490683742 1.74956879440225e-10 NA NA NA hsa-miR-590-3p GNG2 -0.279244755376859 0.59126669933662 0.0195340430449504 0.979278777912881 PITA;miRanda;mirMAP;miRNATAP -0.303311140058288 1.78060575179079e-08 NA NA NA hsa-miR-590-5p GNG2 -0.547819833829572 0.472735645776647 0.0195340430449504 0.979278777912881 miRanda;miRNATAP -0.439716839118106 1.22994799871499e-15 NA NA NA hsa-miR-107 GNG4 -0.0365118169251648 0.988364120226869 1.84581685520606 0.106830658057134 miRanda -1.27199608515578 0.000391434796021852 NA NA NA hsa-miR-326 GNG4 -0.567362118421427 0.620696901956282 1.84581685520606 0.106830658057134 mirMAP -0.591891390234571 0.00769380962383159 NA NA NA hsa-miR-92b-3p GNG4 -0.569866984318692 0.689321861489779 1.84581685520606 0.106830658057134 mirMAP -1.2700609691718 1.42912811264855e-10 NA NA NA hsa-let-7e-5p GNG5 0.211156073215582 0.922335699862928 -0.0596525576668432 0.969200086592649 miRNAWalker2_validate;MirTarget;miRNATAP -0.152599954940069 0.000935964234834591 NA NA NA hsa-miR-100-5p GNG5 0.0230258429671419 0.992818348620337 -0.0596525576668432 0.969200086592649 miRNAWalker2_validate -0.110038434475218 6.92564352999007e-06 NA NA NA hsa-miR-1254 GNG7 -0.488929355953681 0.19551794273322 0.246962625535847 0.547777583589041 miRNATAP -0.238000091347327 0.00103086348244356 NA NA NA hsa-miR-1275 GNG7 -0.831342050607648 0.0803795852164229 0.246962625535847 0.547777583589041 MirTarget -0.253274883294583 8.49390362621298e-06 NA NA NA hsa-miR-141-3p GNG7 -0.31994058840327 0.87774106909065 0.246962625535847 0.547777583589041 MirTarget;TargetScan;miRNATAP -0.426609282329358 1.71346927725291e-08 NA NA NA hsa-miR-17-3p GNG7 0.100221625453134 0.960113387014848 0.246962625535847 0.547777583589041 mirMAP -0.457795100534964 5.89732785575079e-07 NA NA NA hsa-miR-185-3p GNG7 0.100697585937245 0.856913315942984 0.246962625535847 0.547777583589041 mirMAP -0.339810106428788 0.000274824912019918 NA NA NA hsa-miR-18a-3p GNG7 -0.270443061178857 0.535291623032886 0.246962625535847 0.547777583589041 mirMAP -0.372675848820419 8.40351957213415e-09 NA NA NA hsa-miR-18a-5p GNG7 -0.498318455303917 0.61264091975585 0.246962625535847 0.547777583589041 mirMAP -0.364039130076836 2.46209226912081e-08 NA NA NA hsa-miR-18b-5p GNG7 -0.0473300652227538 0.899981261531446 0.246962625535847 0.547777583589041 mirMAP -0.29344950018203 5.72431189988229e-06 NA NA NA hsa-miR-194-3p GNG7 -0.614465699221301 0.733214497063146 0.246962625535847 0.547777583589041 mirMAP -0.410204751461776 2.53365558396796e-08 NA NA NA hsa-miR-200a-3p GNG7 -0.367034437440907 0.851059894150266 0.246962625535847 0.547777583589041 MirTarget;miRNATAP -0.270525770292695 0.000324574104520852 NA NA NA hsa-miR-224-5p GNG7 -0.240425158977724 0.857351098476517 0.246962625535847 0.547777583589041 mirMAP -0.226345207198485 0.000704216351614613 NA NA NA hsa-miR-23a-3p GNG7 -0.122198715333656 0.962717452143511 0.246962625535847 0.547777583589041 mirMAP -0.662403717203233 8.36604672470328e-05 NA NA NA hsa-miR-29b-3p GNG7 -0.104016192263954 0.958988036765397 0.246962625535847 0.547777583589041 mirMAP -0.324547807263863 0.000339788096249608 NA NA NA hsa-miR-378a-3p GNG7 -0.466787210598086 0.795055970353024 0.246962625535847 0.547777583589041 mirMAP -0.276746787489566 0.00640129635092456 NA NA NA hsa-miR-500a-3p GNG7 -0.633375813338735 0.732582832733155 0.246962625535847 0.547777583589041 mirMAP -0.454023927839378 4.92459324117066e-07 NA NA NA hsa-miR-532-3p GNG7 -0.496590111092324 0.682889021782543 0.246962625535847 0.547777583589041 mirMAP -0.354741011856059 1.32513389076964e-05 NA NA NA hsa-miR-590-3p GNG7 -0.279244755376859 0.59126669933662 0.246962625535847 0.547777583589041 PITA;miRanda;mirMAP -0.321886723997531 2.03158812402469e-05 NA NA NA hsa-miR-671-5p GNG7 -0.373754118103105 0.411207779636977 0.246962625535847 0.547777583589041 mirMAP -0.520896997203422 1.71810553995385e-08 NA NA NA hsa-miR-92a-3p GNG7 0.0278830870766349 0.993247426671713 0.246962625535847 0.547777583589041 miRNAWalker2_validate -0.521267148270826 1.29668623808043e-08 NA NA NA hsa-miR-939-5p GNG7 -0.311196961912953 0.304447903545905 0.246962625535847 0.547777583589041 mirMAP -0.360632599824294 5.47831469766152e-06 NA NA NA hsa-miR-940 GNG7 -0.225788347550697 0.680055767105815 0.246962625535847 0.547777583589041 MirTarget -0.325319226450819 4.03321988919025e-07 NA NA NA hsa-miR-96-5p GNG7 0.0854810872029343 0.923087820185031 0.246962625535847 0.547777583589041 mirMAP -0.217584414157617 0.00558972226725726 NA NA NA hsa-miR-30c-1-3p GNGT2 -0.202466672579761 0.511485842123022 -0.283259474818092 0.395401322995797 MirTarget -0.315791055608415 9.18901662482701e-07 NA NA NA hsa-miR-335-5p GNGT2 -0.0284895175847679 0.973380867832231 -0.283259474818092 0.395401322995797 miRNAWalker2_validate -0.507290035048998 1.40241268864283e-14 NA NA NA hsa-miR-1275 GRIN1 -0.831342050607648 0.0803795852164229 -0.148910479687211 0.770049352352482 PITA -0.240521659619254 0.00437577975849337 NA NA NA hsa-let-7a-3p GRIN2A -0.215598045625677 0.85543299203799 0.268474819739478 0.788445562803975 mirMAP -0.682673872890101 8.80479134013245e-06 NA NA NA hsa-let-7b-3p GRIN2A -0.286212135502696 0.812160509578046 0.268474819739478 0.788445562803975 mirMAP -0.578655598392276 0.00295860585952578 NA NA NA hsa-let-7f-1-3p GRIN2A -0.31101436822914 0.693407210545374 0.268474819739478 0.788445562803975 mirMAP -1.25217992184717 1.14757476307437e-09 NA NA NA hsa-miR-107 GRIN2A -0.0365118169251648 0.988364120226869 0.268474819739478 0.788445562803975 miRanda -1.2127258851744 1.65822831669135e-07 NA NA NA hsa-miR-1254 GRIN2A -0.488929355953681 0.19551794273322 0.268474819739478 0.788445562803975 PITA -0.399585930294198 0.000321260090785839 NA NA NA hsa-miR-130b-5p GRIN2A -0.6472141103776 0.379096015222509 0.268474819739478 0.788445562803975 mirMAP -1.14167647254508 8.64756056041577e-20 NA NA NA hsa-miR-148b-5p GRIN2A -0.236618793990305 0.43925706879726 0.268474819739478 0.788445562803975 mirMAP -0.865470900439866 1.70179912368651e-12 NA NA NA hsa-miR-15b-3p GRIN2A -0.557749208157585 0.609181305423188 0.268474819739478 0.788445562803975 mirMAP -1.13580853206484 3.75277622341866e-17 NA NA NA hsa-miR-182-5p GRIN2A -0.104238497940557 0.973380614062243 0.268474819739478 0.788445562803975 mirMAP -0.647665093270354 8.7492084979046e-08 NA NA NA hsa-miR-186-5p GRIN2A -0.318786974828757 0.85412722938961 0.268474819739478 0.788445562803975 mirMAP -1.330500180419 1.63056299684677e-12 NA NA NA hsa-miR-193a-3p GRIN2A -0.247265785363732 0.654363581941634 0.268474819739478 0.788445562803975 miRanda -0.378159506485948 0.0041495904221309 NA NA NA hsa-miR-200b-3p GRIN2A -0.426401948379212 0.863957108574195 0.268474819739478 0.788445562803975 TargetScan -1.11831913910957 1.32826866455372e-18 NA NA NA hsa-miR-224-5p GRIN2A -0.240425158977724 0.857351098476517 0.268474819739478 0.788445562803975 mirMAP -0.470435332445261 3.51330017819878e-06 NA NA NA hsa-miR-23a-3p GRIN2A -0.122198715333656 0.962717452143511 0.268474819739478 0.788445562803975 mirMAP -1.13040096014215 1.12948905245434e-05 NA NA NA hsa-miR-25-3p GRIN2A -0.457540448732733 0.878574066837636 0.268474819739478 0.788445562803975 mirMAP -1.40934658050165 5.34639418806566e-14 NA NA NA hsa-miR-29a-5p GRIN2A -0.31835175571979 0.600442757817281 0.268474819739478 0.788445562803975 mirMAP -0.760003708495944 9.35096320473906e-10 NA NA NA hsa-miR-32-3p GRIN2A -0.568003960723004 0.13133163420273 0.268474819739478 0.788445562803975 mirMAP -0.648050911546398 3.20042469444005e-11 NA NA NA hsa-miR-320a GRIN2A -0.416546433767628 0.840202138616422 0.268474819739478 0.788445562803975 PITA -0.536815277620297 0.00131481011113005 NA NA NA hsa-miR-335-3p GRIN2A -0.244830745789445 0.88450019116631 0.268474819739478 0.788445562803975 mirMAP -0.893485701464524 2.24927649482279e-13 NA NA NA hsa-miR-33a-3p GRIN2A -0.794543849238581 0.0105203072007922 0.268474819739478 0.788445562803975 mirMAP -0.663656905623312 9.72793551348539e-09 NA NA NA hsa-miR-361-5p GRIN2A -0.138735309928775 0.941495130308343 0.268474819739478 0.788445562803975 miRanda -0.963711772280005 4.37391043997374e-05 NA NA NA hsa-miR-362-3p GRIN2A -0.721040238345347 0.0345881362485733 0.268474819739478 0.788445562803975 miRanda -0.452386132831473 6.54715650249287e-05 NA NA NA hsa-miR-491-3p GRIN2A -0.513850326596847 0.137836285146052 0.268474819739478 0.788445562803975 mirMAP -0.47677046180383 4.33989950608505e-05 NA NA NA hsa-miR-539-5p GRIN2A 0.124342970087029 0.801067485473643 0.268474819739478 0.788445562803975 mirMAP -0.503353651115391 0.00107361891583619 NA NA NA hsa-miR-577 GRIN2A -1.06238199218774 0.326056761787754 0.268474819739478 0.788445562803975 PITA -0.546378843392519 1.83972124919998e-15 NA NA NA hsa-miR-582-5p GRIN2A -0.399450205475138 0.581227478860085 0.268474819739478 0.788445562803975 mirMAP -0.600772314943332 6.86498658750258e-05 NA NA NA hsa-miR-590-3p GRIN2A -0.279244755376859 0.59126669933662 0.268474819739478 0.788445562803975 miRanda;mirMAP -0.723510345867427 1.5606298251195e-10 NA NA NA hsa-miR-590-5p GRIN2A -0.547819833829572 0.472735645776647 0.268474819739478 0.788445562803975 miRanda -0.875410277534251 1.01160535444828e-13 NA NA NA hsa-miR-592 GRIN2A -0.177670083168544 0.856226890424691 0.268474819739478 0.788445562803975 PITA -0.154000080430083 0.00933249790450634 NA NA NA hsa-miR-629-5p GRIN2A -0.385679366494342 0.798536530066869 0.268474819739478 0.788445562803975 mirMAP -0.671655373636193 1.1630030378298e-07 NA NA NA hsa-miR-7-1-3p GRIN2A -0.462485777435991 0.665899751398166 0.268474819739478 0.788445562803975 mirMAP -0.926171151117631 1.66389723676493e-12 NA NA NA hsa-miR-877-5p GRIN2A -0.317720731672575 0.435952264022643 0.268474819739478 0.788445562803975 mirMAP -0.423841588528835 2.89236429823779e-05 NA NA NA hsa-miR-92a-3p GRIN2A 0.0278830870766349 0.993247426671713 0.268474819739478 0.788445562803975 mirMAP -1.08644510946318 1.32653017292102e-15 NA NA NA hsa-let-7a-3p HGF -0.215598045625677 0.85543299203799 -0.215102594830841 0.643434051530302 mirMAP -0.88420347185405 1.1709285303706e-11 NA NA NA hsa-let-7f-1-3p HGF -0.31101436822914 0.693407210545374 -0.215102594830841 0.643434051530302 mirMAP -0.831761669295677 5.5433774063152e-06 NA NA NA hsa-miR-126-5p HGF 0.0815213541035824 0.956637332055185 -0.215102594830841 0.643434051530302 mirMAP -0.519453817781097 0.000972844074417936 NA NA NA hsa-miR-140-5p HGF -0.229213026275906 0.847330111738616 -0.215102594830841 0.643434051530302 miRanda -0.65487174403206 0.000253507908779553 NA NA NA hsa-miR-141-3p HGF -0.31994058840327 0.87774106909065 -0.215102594830841 0.643434051530302 MirTarget;TargetScan -0.730579886607172 1.58446647058152e-13 NA NA NA hsa-miR-200a-3p HGF -0.367034437440907 0.851059894150266 -0.215102594830841 0.643434051530302 MirTarget -0.596497453806514 1.29203788778455e-09 NA NA NA hsa-miR-203a-3p HGF -0.265248086637561 0.931593594361942 -0.215102594830841 0.643434051530302 MirTarget -0.461332142848555 2.60147483748182e-07 NA NA NA hsa-miR-26b-5p HGF -0.0245931278499594 0.990377966314923 -0.215102594830841 0.643434051530302 MirTarget;miRNATAP -1.17315397215506 4.58480300345712e-14 NA NA NA hsa-miR-29a-5p HGF -0.31835175571979 0.600442757817281 -0.215102594830841 0.643434051530302 mirMAP -0.708270081145091 5.09040194854006e-11 NA NA NA hsa-miR-30b-5p HGF -0.0121430518253582 0.994622896704513 -0.215102594830841 0.643434051530302 mirMAP -0.730375715452008 3.65541666930056e-10 NA NA NA hsa-miR-30c-5p HGF -0.298383882401475 0.865809030482001 -0.215102594830841 0.643434051530302 mirMAP -0.897019003354754 1.14472391149967e-07 NA NA NA hsa-miR-30e-5p HGF -0.0657075181381011 0.979684509181941 -0.215102594830841 0.643434051530302 mirMAP -0.58046350738056 0.00239259261354955 NA NA NA hsa-miR-335-3p HGF -0.244830745789445 0.88450019116631 -0.215102594830841 0.643434051530302 mirMAP -0.39255303662723 0.000430581302657786 NA NA NA hsa-miR-338-3p HGF 0.49158501750012 0.788483749194189 -0.215102594830841 0.643434051530302 miRanda -0.295029479608896 0.00119469331586222 NA NA NA hsa-miR-33a-3p HGF -0.794543849238581 0.0105203072007922 -0.215102594830841 0.643434051530302 mirMAP -0.485665076665164 2.0568759682243e-06 NA NA NA hsa-miR-421 HGF -0.182032017078616 0.734704500318599 -0.215102594830841 0.643434051530302 miRanda -0.35008082810766 0.00288860800589552 NA NA NA hsa-miR-429 HGF -0.456485631615963 0.806240953400535 -0.215102594830841 0.643434051530302 miRanda -0.631479963725932 1.15314842800372e-11 NA NA NA hsa-miR-582-5p HGF -0.399450205475138 0.581227478860085 -0.215102594830841 0.643434051530302 PITA -0.652283879342961 5.81074982694297e-07 NA NA NA hsa-miR-590-3p HGF -0.279244755376859 0.59126669933662 -0.215102594830841 0.643434051530302 miRanda;mirMAP -0.738231418622318 2.66582687148553e-14 NA NA NA hsa-miR-590-5p HGF -0.547819833829572 0.472735645776647 -0.215102594830841 0.643434051530302 miRanda -0.824314223851123 5.14472586927879e-16 NA NA NA hsa-miR-651-5p HGF -0.571699708815578 0.172535889612301 -0.215102594830841 0.643434051530302 MirTarget -0.452996451589744 5.92177771892613e-07 NA NA NA hsa-miR-7-1-3p HGF -0.462485777435991 0.665899751398166 -0.215102594830841 0.643434051530302 mirMAP -0.71251071506092 8.68300493786797e-10 NA NA NA hsa-miR-29a-3p HTR7 0.01127474410284 0.996977020481272 -0.234337825131208 0.768110082373248 miRNATAP -0.776319923104126 5.01939039558216e-08 NA NA NA hsa-miR-29b-3p HTR7 -0.104016192263954 0.958988036765397 -0.234337825131208 0.768110082373248 miRNATAP -0.649517727151251 1.28055289958365e-09 NA NA NA hsa-miR-324-5p HTR7 -0.50063248413014 0.537416710557032 -0.234337825131208 0.768110082373248 miRanda -0.389827760752351 0.000833321662298424 NA NA NA hsa-miR-335-5p HTR7 -0.0284895175847679 0.973380867832231 -0.234337825131208 0.768110082373248 miRNAWalker2_validate -0.505398465706354 4.06425499995556e-07 NA NA NA hsa-let-7a-3p IGF1 -0.215598045625677 0.85543299203799 0.00947737435165086 0.987467926907962 mirMAP -1.080447980324 1.8079365656541e-11 NA NA NA hsa-let-7f-1-3p IGF1 -0.31101436822914 0.693407210545374 0.00947737435165086 0.987467926907962 mirMAP -1.33703011462655 1.62041677524579e-09 NA NA NA hsa-miR-1275 IGF1 -0.831342050607648 0.0803795852164229 0.00947737435165086 0.987467926907962 MirTarget;PITA -0.38101781548121 5.45983739511041e-05 NA NA NA hsa-miR-130b-3p IGF1 -0.221667315324818 0.824660172394714 0.00947737435165086 0.987467926907962 MirTarget -1.32997411476354 1.36901225432237e-20 NA NA NA hsa-miR-148a-5p IGF1 -0.448099743845604 0.748419139652266 0.00947737435165086 0.987467926907962 mirMAP -0.731184313112099 6.87872094016325e-07 NA NA NA hsa-miR-15b-3p IGF1 -0.557749208157585 0.609181305423188 0.00947737435165086 0.987467926907962 mirMAP -1.37193595831155 3.68702917896959e-22 NA NA NA hsa-miR-16-1-3p IGF1 0.151694812889216 0.733736501874638 0.00947737435165086 0.987467926907962 mirMAP -0.870110401826923 9.48782291894495e-12 NA NA NA hsa-miR-186-5p IGF1 -0.318786974828757 0.85412722938961 0.00947737435165086 0.987467926907962 mirMAP -1.35027272960641 3.80273001614756e-11 NA NA NA hsa-miR-19a-3p IGF1 -0.206793507801887 0.844637784802316 0.00947737435165086 0.987467926907962 MirTarget -0.98551271469101 4.98535421174768e-17 NA NA NA hsa-miR-19b-1-5p IGF1 -0.0105982583216702 0.988511655226679 0.00947737435165086 0.987467926907962 mirMAP -0.955450359137311 6.7696545868365e-13 NA NA NA hsa-miR-19b-3p IGF1 -0.0268530183621474 0.986656783046572 0.00947737435165086 0.987467926907962 MirTarget -1.18511578469291 3.16855554305294e-17 NA NA NA hsa-miR-20a-3p IGF1 0.456808229166028 0.57674056136504 0.00947737435165086 0.987467926907962 mirMAP -0.828202370369737 4.46601232058444e-17 NA NA NA hsa-miR-224-3p IGF1 0.110372723153393 0.749091467231007 0.00947737435165086 0.987467926907962 mirMAP -0.323141310332858 0.00752558553987227 NA NA NA hsa-miR-26b-5p IGF1 -0.0245931278499594 0.990377966314923 0.00947737435165086 0.987467926907962 mirMAP -1.32653848815452 7.59461749262891e-12 NA NA NA hsa-miR-27a-3p IGF1 -0.123902317731458 0.958804393510999 0.00947737435165086 0.987467926907962 miRNAWalker2_validate;miRTarBase -1.33297141089179 1.59629899773494e-08 NA NA NA hsa-miR-29a-3p IGF1 0.01127474410284 0.996977020481272 0.00947737435165086 0.987467926907962 MirTarget -1.21646810613425 2.24809293601906e-10 NA NA NA hsa-miR-29b-3p IGF1 -0.104016192263954 0.958988036765397 0.00947737435165086 0.987467926907962 MirTarget -1.13478255405874 1.02581838525823e-15 25592039 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 IGF1 3' untranslated region 3'UTR; IGF1 an activator of PI3K/Akt signaling was confirmed as a novel target of miR-29b colorectal cancer hsa-miR-301a-3p IGF1 -0.105312511901769 0.831686745977347 0.00947737435165086 0.987467926907962 MirTarget -0.72462477830808 1.53712615625093e-08 NA NA NA hsa-miR-32-3p IGF1 -0.568003960723004 0.13133163420273 0.00947737435165086 0.987467926907962 mirMAP -0.854296588628844 6.36098490896109e-17 NA NA NA hsa-miR-320a IGF1 -0.416546433767628 0.840202138616422 0.00947737435165086 0.987467926907962 miRNATAP -0.53324783195833 0.00309104675893166 NA NA NA hsa-miR-33a-3p IGF1 -0.794543849238581 0.0105203072007922 0.00947737435165086 0.987467926907962 MirTarget -0.712659254532177 1.07475387901444e-08 NA NA NA hsa-miR-361-5p IGF1 -0.138735309928775 0.941495130308343 0.00947737435165086 0.987467926907962 PITA;mirMAP -0.7571457599163 0.00312625171582628 NA NA NA hsa-miR-362-5p IGF1 -0.26647467080141 0.752024885130738 0.00947737435165086 0.987467926907962 mirMAP -0.685362314110393 1.45434246224861e-09 NA NA NA hsa-miR-369-3p IGF1 0.116576891957687 0.83230082995912 0.00947737435165086 0.987467926907962 mirMAP -0.416113550798216 0.00731803332568262 NA NA NA hsa-miR-374b-3p IGF1 -0.0542885924440247 0.860753623992354 0.00947737435165086 0.987467926907962 mirMAP -0.901177033447461 2.85340453160353e-08 NA NA NA hsa-miR-376b-3p IGF1 -0.00712550627858333 0.982426403308526 0.00947737435165086 0.987467926907962 mirMAP -0.400180241759986 0.00219046891964139 NA NA NA hsa-miR-377-3p IGF1 -0.0435868040110954 0.893514136702459 0.00947737435165086 0.987467926907962 mirMAP -0.347398016761275 0.00944572443583628 NA NA NA hsa-miR-421 IGF1 -0.182032017078616 0.734704500318599 0.00947737435165086 0.987467926907962 PITA -0.682640976463619 1.66568557959283e-06 NA NA NA hsa-miR-450b-5p IGF1 -0.0136687538973108 0.983149761399849 0.00947737435165086 0.987467926907962 MirTarget;PITA;mirMAP;miRNATAP -0.440274691286941 0.00526886632157137 NA NA NA hsa-miR-452-5p IGF1 -0.0504626418153507 0.973874641360401 0.00947737435165086 0.987467926907962 MirTarget;mirMAP -0.391677573462921 0.00721587803462884 NA NA NA hsa-miR-454-3p IGF1 -0.101514866328011 0.843545158256191 0.00947737435165086 0.987467926907962 MirTarget -1.21083489236632 2.3904507521785e-12 NA NA NA hsa-miR-486-5p IGF1 -0.547739229538641 0.696404149927963 0.00947737435165086 0.987467926907962 PITA;miRNATAP -0.27962476093108 0.00602263294023068 NA NA NA hsa-miR-576-5p IGF1 -0.506413219377403 0.417187951364173 0.00947737435165086 0.987467926907962 PITA;mirMAP;miRNATAP -1.07532866336442 7.30778925637395e-14 NA NA NA hsa-miR-577 IGF1 -1.06238199218774 0.326056761787754 0.00947737435165086 0.987467926907962 PITA -0.608739982603203 1.28953846721018e-16 NA NA NA hsa-miR-590-3p IGF1 -0.279244755376859 0.59126669933662 0.00947737435165086 0.987467926907962 MirTarget;miRanda;mirMAP;miRNATAP -0.902455239090903 4.54122052117076e-14 NA NA NA hsa-miR-592 IGF1 -0.177670083168544 0.856226890424691 0.00947737435165086 0.987467926907962 mirMAP -0.176568829642714 0.00558894888386371 NA NA NA hsa-miR-629-5p IGF1 -0.385679366494342 0.798536530066869 0.00947737435165086 0.987467926907962 mirMAP -0.580583415149519 2.61578695347913e-05 NA NA NA hsa-miR-940 IGF1 -0.225788347550697 0.680055767105815 0.00947737435165086 0.987467926907962 MirTarget;PITA;miRNATAP -0.565084064749585 9.24954782359072e-08 NA NA NA hsa-let-7a-5p IGF1R -0.0620211756550422 0.985006886285188 -0.103803406345425 0.938733891850032 MirTarget;TargetScan;miRNATAP -0.243160250350556 0.00491064759282066 23974362 Reduced microRNA miRNA let-7a expression and the activation of insulin-like growth factor-1 receptor IGF1R signalling are both involved in prostate cancer and progression; TargetScan predicted three potential target sites T1 T2 and T3 of let-7a in the 3' untranslational region 3' UTR of IGF1R mRNA progression prostate cancer hsa-let-7f-5p IGF1R 0.048789917034723 0.987280455481631 -0.103803406345425 0.938733891850032 MirTarget;miRNATAP -0.256299916151521 0.000451131242842245 NA NA NA hsa-miR-141-5p IGF1R -0.354590233549885 0.867642456336402 -0.103803406345425 0.938733891850032 mirMAP -0.113052742477114 0.00877702512535289 27648145 Insulin-like growth factor 1 receptor IGF1R was overexpressed in AGS cells to investigate miR-141 mechanism gastric cancer hsa-miR-146b-5p IGF1R -0.402662509440887 0.837510937985091 -0.103803406345425 0.938733891850032 miRanda -0.173301214951841 0.00128805370965098 NA NA NA hsa-miR-148a-5p IGF1R -0.448099743845604 0.748419139652266 -0.103803406345425 0.938733891850032 mirMAP -0.148035854798968 0.00161166437750514 NA NA NA hsa-miR-155-5p IGF1R -0.407235807706004 0.828669616718496 -0.103803406345425 0.938733891850032 mirMAP -0.157172052561045 0.000741470115136315 NA NA NA hsa-miR-15a-5p IGF1R -0.0674049094129128 0.964835434214123 -0.103803406345425 0.938733891850032 miRNATAP -0.216892021259061 0.000131806631798513 NA NA NA hsa-miR-15b-5p IGF1R -0.272614787130877 0.87096541832188 -0.103803406345425 0.938733891850032 miRNATAP -0.162032707167887 0.00249732533293442 NA NA NA hsa-miR-16-5p IGF1R 0.0135949734723564 0.994476223855607 -0.103803406345425 0.938733891850032 miRNATAP -0.147034771165486 0.00601666576845021 23507142 Furthermore we confirmed that IGF1R is a direct target of miR-16; In clinical specimens IGF1R levels inversely correlate with miR-16 expression; Our results provide significant clues regarding the role of miR-16 as a tumor suppressor by targeting IGF1R in OS sarcoma hsa-miR-185-5p IGF1R -0.294432218239008 0.820591478398594 -0.103803406345425 0.938733891850032 MirTarget -0.291974153890838 9.35911241773559e-06 NA NA NA hsa-miR-186-5p IGF1R -0.318786974828757 0.85412722938961 -0.103803406345425 0.938733891850032 mirMAP -0.189895543661092 0.00437029938165362 NA NA NA hsa-miR-378a-3p IGF1R -0.466787210598086 0.795055970353024 -0.103803406345425 0.938733891850032 miRTarBase;MirTarget;miRNATAP -0.164856274068005 0.00167500175777631 24119742;25427715;24412052 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS; MiR-378a-3p over-expression in an RMS-derived cell line suppressed IGF1R expression and affected phosphorylated-Akt protein levels;Furthermore miR-378a-3p over-expression or down-regulation could inhibit or enhance insulin-like growth factor 1 receptor IGF1R expression in CRC cells; There was a significantly negative correlation between IGF1R protein expression and miR-378a-3p expression in CRC tissues ;; liver cancer;sarcoma;colorectal cancer hsa-miR-378a-5p IGF1R -0.559739196974497 0.724882066659501 -0.103803406345425 0.938733891850032 mirMAP -0.175396977324042 0.00026465398131805 24119742;25427715 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS ; liver cancer;sarcoma hsa-miR-484 IGF1R -0.179977202691249 0.886333755572375 -0.103803406345425 0.938733891850032 miRNAWalker2_validate -0.245668841067247 2.83524395118817e-05 NA NA NA hsa-miR-625-5p IGF1R -0.690759472145277 0.210306534567564 -0.103803406345425 0.938733891850032 MirTarget -0.103547661533949 0.0029191222627627 NA NA NA hsa-miR-629-3p IGF1R -0.495402745812008 0.333967382214384 -0.103803406345425 0.938733891850032 mirMAP -0.122852401902141 0.00121467574004489 NA NA NA hsa-miR-671-5p IGF1R -0.373754118103105 0.411207779636977 -0.103803406345425 0.938733891850032 mirMAP -0.127729526914725 0.0095060454236158 NA NA NA hsa-miR-7-5p IGF1R 0.209645143210379 0.773705612298441 -0.103803406345425 0.938733891850032 miRNAWalker2_validate;mirMAP -0.123016255458274 2.76809127732144e-05 22614005 Moreover the insulin-like growth factor-1 receptor IGF1R oncogene which is often mutated or amplified in human cancers and functions as an important regulator of cell growth and tumor invasion was identified as a direct target of miR-7; Silencing of IGF1R using small interefering RNA siRNA recapitulated the anti-metastatic function of miR-7 whereas restoring the IGF1R expression attenuated the function of miR-7 in GC cells; Finally analyses of miR-7 and IGF1R levels in human primary GC with matched lymph node metastasis tissue arrays revealed that miR-7 is inversely correlated with IGF1R expression metastasis gastric cancer hsa-let-7a-5p IGF2 -0.0620211756550422 0.985006886285188 0.558178390369186 0.699874555090261 miRNAWalker2_validate;miRTarBase -1.32775282562246 0.000276437161830582 NA NA NA hsa-miR-141-3p IGF2 -0.31994058840327 0.87774106909065 0.558178390369186 0.699874555090261 MirTarget;TargetScan -0.690444519894233 4.62610267953503e-05 NA NA NA hsa-miR-148a-3p IGF2 -0.101286586375016 0.976980454193186 0.558178390369186 0.699874555090261 mirMAP -0.605151946492803 0.00346322379059377 NA NA NA hsa-miR-192-5p IGF2 -0.117345487848223 0.972927287653137 0.558178390369186 0.699874555090261 mirMAP -0.665311544607333 2.50041119586102e-05 NA NA NA hsa-miR-200a-3p IGF2 -0.367034437440907 0.851059894150266 0.558178390369186 0.699874555090261 MirTarget -0.546401873597961 0.00100494917147672 NA NA NA hsa-miR-210-3p IGF2 -0.531610638853144 0.78220772117333 0.558178390369186 0.699874555090261 MirTarget -0.419493273578115 0.000199381136218303 NA NA NA hsa-miR-663b IGF2 0.101100389887233 0.814989939749933 0.558178390369186 0.699874555090261 mirMAP -0.375405545344549 0.00418142774332847 NA NA NA hsa-miR-151a-3p INSR -0.0829874640636401 0.975334671097605 -0.257802126655543 0.855679559467316 miRNATAP -0.188107675065737 0.00147636742580037 NA NA NA hsa-miR-335-3p INSR -0.244830745789445 0.88450019116631 -0.257802126655543 0.855679559467316 mirMAP -0.137501879355718 0.000193797807972045 23966614 miR 335 inhibits small cell lung cancer bone metastases via IGF IR and RANKL pathways metastasis lung squamous cell cancer hsa-miR-125a-3p KDR 0.14689780893708 0.724764670752407 -0.0378454433977167 0.969000712782508 miRanda -0.135037586070917 0.00574147931378875 NA NA NA hsa-miR-149-5p KDR -0.0341785025317569 0.961061088204977 -0.0378454433977167 0.969000712782508 miRNATAP -0.17679282170212 0.000285005104916724 NA NA NA hsa-miR-15a-5p KDR -0.0674049094129128 0.964835434214123 -0.0378454433977167 0.969000712782508 miRNATAP -0.247900839321602 0.000786634287471638 NA NA NA hsa-miR-15b-5p KDR -0.272614787130877 0.87096541832188 -0.0378454433977167 0.969000712782508 miRNATAP -0.332368961924666 1.15770508385152e-06 NA NA NA hsa-miR-16-5p KDR 0.0135949734723564 0.994476223855607 -0.0378454433977167 0.969000712782508 miRTarBase;miRNATAP -0.374448057849181 3.0607960906155e-08 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2 colorectal cancer hsa-miR-200b-3p KDR -0.426401948379212 0.863957108574195 -0.0378454433977167 0.969000712782508 miRNAWalker2_validate;miRTarBase;TargetScan -0.236585472095174 7.02568520730331e-05 NA NA NA hsa-miR-200c-3p KDR -0.437282635857873 0.887118598436407 -0.0378454433977167 0.969000712782508 miRNATAP -0.237398352198661 0.000107602125893105 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-335-5p KDR -0.0284895175847679 0.973380867832231 -0.0378454433977167 0.969000712782508 miRNAWalker2_validate -0.29736800202028 6.48712589791683e-08 NA NA NA hsa-miR-429 KDR -0.456485631615963 0.806240953400535 -0.0378454433977167 0.969000712782508 PITA;miRanda;miRNATAP -0.230423787210216 1.43465883215394e-06 NA NA NA hsa-miR-590-3p KDR -0.279244755376859 0.59126669933662 -0.0378454433977167 0.969000712782508 miRanda -0.316586357786352 1.57111917265935e-10 NA NA NA hsa-miR-590-5p KDR -0.547819833829572 0.472735645776647 -0.0378454433977167 0.969000712782508 miRanda -0.328964510777447 3.46134712737495e-10 NA NA NA hsa-let-7a-3p KIT -0.215598045625677 0.85543299203799 0.457668701771759 0.496616548931543 mirMAP -0.3809217229143 0.00182630278028915 NA NA NA hsa-let-7f-1-3p KIT -0.31101436822914 0.693407210545374 0.457668701771759 0.496616548931543 mirMAP -0.482657875905786 0.00387615090443827 NA NA NA hsa-miR-128-3p KIT -0.442192625156042 0.783886533572187 0.457668701771759 0.496616548931543 MirTarget -0.59687102544161 2.27908242272046e-05 NA NA NA hsa-miR-130b-3p KIT -0.221667315324818 0.824660172394714 0.457668701771759 0.496616548931543 miRNATAP -0.651236322715464 3.80557067482672e-09 NA NA NA hsa-miR-186-5p KIT -0.318786974828757 0.85412722938961 0.457668701771759 0.496616548931543 miRNAWalker2_validate -0.643356802872238 2.81688585045994e-05 NA NA NA hsa-miR-19a-3p KIT -0.206793507801887 0.844637784802316 0.457668701771759 0.496616548931543 miRTarBase;miRNATAP -0.500657917313782 2.31587429085004e-08 NA NA NA hsa-miR-19b-3p KIT -0.0268530183621474 0.986656783046572 0.457668701771759 0.496616548931543 miRNATAP -0.546027135667705 4.14767067130833e-07 NA NA NA hsa-miR-20a-5p KIT -0.179153323927949 0.928118119139752 0.457668701771759 0.496616548931543 miRTarBase -0.43960652214484 2.80259629126038e-06 NA NA NA hsa-miR-221-3p KIT 0.0906940388127513 0.959121118272534 0.457668701771759 0.496616548931543 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.666863756385362 6.28864219420986e-07 NA NA NA hsa-miR-222-3p KIT -0.0265849318772702 0.984005474689108 0.457668701771759 0.496616548931543 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.686230651819729 7.25180673792435e-09 NA NA NA hsa-miR-301a-3p KIT -0.105312511901769 0.831686745977347 0.457668701771759 0.496616548931543 miRNATAP -0.387224289504154 4.76195927223164e-05 NA NA NA hsa-miR-335-3p KIT -0.244830745789445 0.88450019116631 0.457668701771759 0.496616548931543 mirMAP -0.343434169049267 0.00062897018563524 NA NA NA hsa-miR-335-5p KIT -0.0284895175847679 0.973380867832231 0.457668701771759 0.496616548931543 miRNAWalker2_validate -0.366587972857823 0.000271739293378917 NA NA NA hsa-miR-421 KIT -0.182032017078616 0.734704500318599 0.457668701771759 0.496616548931543 miRanda -0.382197532209103 0.000282334300402079 NA NA NA hsa-miR-429 KIT -0.456485631615963 0.806240953400535 0.457668701771759 0.496616548931543 miRNATAP -0.373983219250199 1.48812607491237e-05 NA NA NA hsa-miR-450b-5p KIT -0.0136687538973108 0.983149761399849 0.457668701771759 0.496616548931543 MirTarget -0.383849702053645 0.000829863075234057 NA NA NA hsa-miR-454-3p KIT -0.101514866328011 0.843545158256191 0.457668701771759 0.496616548931543 miRNATAP -0.553750855301317 2.25336481948067e-05 NA NA NA hsa-miR-501-5p KIT -0.834032628506285 0.0582725160418523 0.457668701771759 0.496616548931543 miRNATAP -0.304925974412707 0.000187216847600768 NA NA NA hsa-miR-505-3p KIT -0.469094267152605 0.690382680489578 0.457668701771759 0.496616548931543 MirTarget;miRNATAP -0.680318326816466 1.74165212679761e-07 NA NA NA hsa-miR-548o-3p KIT -0.191447572716994 0.517725546183501 0.457668701771759 0.496616548931543 mirMAP -0.318295299780355 0.00158677522756669 NA NA NA hsa-miR-577 KIT -1.06238199218774 0.326056761787754 0.457668701771759 0.496616548931543 mirMAP -0.280927780359713 6.31859393201618e-07 NA NA NA hsa-miR-590-3p KIT -0.279244755376859 0.59126669933662 0.457668701771759 0.496616548931543 miRanda;mirMAP -0.443054718781092 1.02016068191292e-06 NA NA NA hsa-miR-671-5p KIT -0.373754118103105 0.411207779636977 0.457668701771759 0.496616548931543 MirTarget -0.563147306056567 5.47110754532317e-07 NA NA NA hsa-miR-17-3p KITLG 0.100221625453134 0.960113387014848 -0.562487131644406 0.618033578661231 MirTarget -0.254488454266064 5.2884195868185e-05 NA NA NA hsa-miR-181c-5p KITLG 0.042951891660695 0.969159991881861 -0.562487131644406 0.618033578661231 MirTarget -0.323428614621384 4.09391985376817e-07 NA NA NA hsa-miR-181d-5p KITLG 0.14926527647499 0.888000971478017 -0.562487131644406 0.618033578661231 MirTarget -0.244523990163924 1.08913173712828e-06 NA NA NA hsa-miR-19a-3p KITLG -0.206793507801887 0.844637784802316 -0.562487131644406 0.618033578661231 mirMAP -0.179390253452666 0.000503630652542308 NA NA NA hsa-miR-19b-3p KITLG -0.0268530183621474 0.986656783046572 -0.562487131644406 0.618033578661231 mirMAP -0.33526934290987 2.83413094765762e-08 NA NA NA hsa-miR-23a-3p KITLG -0.122198715333656 0.962717452143511 -0.562487131644406 0.618033578661231 mirMAP -0.417539718738278 0.000276840145161814 NA NA NA hsa-miR-26a-5p KITLG 0.00698202897993028 0.997719986197021 -0.562487131644406 0.618033578661231 mirMAP -0.441100932004763 0.000244345083329715 NA NA NA hsa-miR-26b-5p KITLG -0.0245931278499594 0.990377966314923 -0.562487131644406 0.618033578661231 mirMAP -0.249959830995195 0.00265203197838094 NA NA NA hsa-miR-30b-5p KITLG -0.0121430518253582 0.994622896704513 -0.562487131644406 0.618033578661231 mirMAP -0.189048907875488 0.00196626029841939 NA NA NA hsa-miR-30e-5p KITLG -0.0657075181381011 0.979684509181941 -0.562487131644406 0.618033578661231 mirMAP -0.288848961135801 0.0028871061901372 NA NA NA hsa-miR-335-3p KITLG -0.244830745789445 0.88450019116631 -0.562487131644406 0.618033578661231 MirTarget -0.201041226663142 0.00037420143920281 NA NA NA hsa-miR-374a-5p KITLG -0.343007247142618 0.766921280269271 -0.562487131644406 0.618033578661231 mirMAP -0.274429035576241 0.00203557679884464 NA NA NA hsa-miR-374b-5p KITLG -0.285682091626878 0.83569830479965 -0.562487131644406 0.618033578661231 mirMAP -0.223620629672349 0.00974897839176574 NA NA NA hsa-miR-452-3p KITLG -0.167134177977311 0.799008246175244 -0.562487131644406 0.618033578661231 mirMAP -0.139985943072296 0.0014897785492864 NA NA NA hsa-miR-126-5p KRAS 0.0815213541035824 0.956637332055185 0.0789064765134055 0.953888724941783 MirTarget -0.119864203753635 0.00133135323525602 22845403 miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK pancreatic cancer hsa-miR-1271-5p KRAS -0.464440824492835 0.095633275297856 0.0789064765134055 0.953888724941783 MirTarget -0.107229521880363 7.56803548098355e-05 NA NA NA hsa-miR-181c-5p KRAS 0.042951891660695 0.969159991881861 0.0789064765134055 0.953888724941783 miRNAWalker2_validate;miRTarBase -0.100747847809848 0.000902565483936579 NA NA NA hsa-miR-199a-5p KRAS 0.157247797504494 0.935797462797012 0.0789064765134055 0.953888724941783 miRanda;miRNATAP -0.106963175847596 0.000895280762960813 NA NA NA hsa-miR-199b-5p KRAS -0.0396557270992508 0.977172718873203 0.0789064765134055 0.953888724941783 miRanda;miRNATAP -0.108743582994301 9.84561646476932e-05 27517624 The miR-199b prognostic impact was particularly evident in both younger and KRAS wild-type subgroups colorectal cancer hsa-miR-30e-5p KRAS -0.0657075181381011 0.979684509181941 0.0789064765134055 0.953888724941783 mirMAP;miRNATAP -0.119414065684219 0.00856624973196858 NA NA NA hsa-miR-200b-3p KSR1 -0.426401948379212 0.863957108574195 0.126386815002735 0.904011598853322 TargetScan;mirMAP -0.107059883937127 0.00872512435273809 NA NA NA hsa-miR-200c-3p KSR1 -0.437282635857873 0.887118598436407 0.126386815002735 0.904011598853322 mirMAP -0.126831932258627 0.00246976152477361 NA NA NA hsa-miR-17-5p KSR2 -0.175448849583061 0.934544015912731 -0.385589220748234 0.317215144731608 mirMAP -0.257145512157932 0.00248524995479174 NA NA NA hsa-miR-194-5p KSR2 -0.159001168846464 0.959682382557336 -0.385589220748234 0.317215144731608 mirMAP -0.244324248761179 0.00616923053642601 NA NA NA hsa-miR-20a-5p KSR2 -0.179153323927949 0.928118119139752 -0.385589220748234 0.317215144731608 mirMAP -0.229072038296822 0.00633287592711002 NA NA NA hsa-miR-23a-3p KSR2 -0.122198715333656 0.962717452143511 -0.385589220748234 0.317215144731608 mirMAP -0.658477384307318 0.000240450688969261 NA NA NA hsa-miR-29a-3p KSR2 0.01127474410284 0.996977020481272 -0.385589220748234 0.317215144731608 mirMAP -0.357264569920668 0.0051842342488981 NA NA NA hsa-miR-29b-3p KSR2 -0.104016192263954 0.958988036765397 -0.385589220748234 0.317215144731608 mirMAP -0.264822039644472 0.00623769557203732 NA NA NA hsa-miR-452-5p KSR2 -0.0504626418153507 0.973874641360401 -0.385589220748234 0.317215144731608 mirMAP -0.24546966852164 0.00881432238491941 NA NA NA hsa-miR-532-5p KSR2 -0.349665553500088 0.878948352437467 -0.385589220748234 0.317215144731608 mirMAP -0.272909169390765 0.00497995316398406 NA NA NA hsa-miR-92a-3p KSR2 0.0278830870766349 0.993247426671713 -0.385589220748234 0.317215144731608 miRNATAP -0.316024413689275 0.00155450715260232 NA NA NA hsa-miR-101-3p MAP2K1 0.0107754887734437 0.997036362636866 -0.0827143668416932 0.951976704641412 miRNAWalker2_validate -0.184567516398963 1.51165586105245e-05 NA NA NA hsa-miR-34c-5p MAP2K1 -0.018707656771723 0.952788306178575 -0.0827143668416932 0.951976704641412 PITA;miRanda -0.110947114920215 0.000102476815991688 NA NA NA hsa-miR-497-5p MAP2K1 -0.0120217191428731 0.989147225742026 -0.0827143668416932 0.951976704641412 miRNAWalker2_validate -0.154029164580327 9.63370868318467e-06 NA NA NA hsa-miR-130b-3p MAPK10 -0.221667315324818 0.824660172394714 0.277853609916948 0.499757905156418 miRNATAP -0.832310234327384 2.2381048276646e-17 NA NA NA hsa-miR-193a-3p MAPK10 -0.247265785363732 0.654363581941634 0.277853609916948 0.499757905156418 miRanda;miRNATAP -0.252213365553003 0.00870398994376484 NA NA NA hsa-miR-19a-3p MAPK10 -0.206793507801887 0.844637784802316 0.277853609916948 0.499757905156418 miRNATAP -0.684018875973696 4.827389622141e-18 NA NA NA hsa-miR-19b-3p MAPK10 -0.0268530183621474 0.986656783046572 0.277853609916948 0.499757905156418 miRNATAP -0.696419816886425 6.76561876995665e-13 NA NA NA hsa-miR-221-3p MAPK10 0.0906940388127513 0.959121118272534 0.277853609916948 0.499757905156418 miRNATAP -0.85742573028989 1.01791917727309e-12 NA NA NA hsa-miR-222-3p MAPK10 -0.0265849318772702 0.984005474689108 0.277853609916948 0.499757905156418 miRNATAP -0.880593901403205 6.71481319542536e-17 NA NA NA hsa-miR-29a-3p MAPK10 0.01127474410284 0.996977020481272 0.277853609916948 0.499757905156418 miRNATAP -0.691098479445333 1.45128452412974e-07 NA NA NA hsa-miR-29b-3p MAPK10 -0.104016192263954 0.958988036765397 0.277853609916948 0.499757905156418 miRNATAP -0.761303371269869 1.76988052622429e-15 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-301a-3p MAPK10 -0.105312511901769 0.831686745977347 0.277853609916948 0.499757905156418 miRNATAP -0.612353493044439 4.61795457460633e-13 NA NA NA hsa-miR-30d-3p MAPK10 -0.123474741320298 0.814905367625791 0.277853609916948 0.499757905156418 mirMAP -0.796380211200875 1.85348051868985e-13 NA NA NA hsa-miR-30e-3p MAPK10 -0.220498559176349 0.938660731870214 0.277853609916948 0.499757905156418 mirMAP -0.516722605634317 0.00602241545561428 NA NA NA hsa-miR-330-3p MAPK10 0.00298687748748416 0.994504006750491 0.277853609916948 0.499757905156418 PITA;miRNATAP -0.375477945370297 0.000760398661857965 NA NA NA hsa-miR-429 MAPK10 -0.456485631615963 0.806240953400535 0.277853609916948 0.499757905156418 miRNATAP -0.63546405917023 3.52018243839143e-17 NA NA NA hsa-miR-450b-5p MAPK10 -0.0136687538973108 0.983149761399849 0.277853609916948 0.499757905156418 mirMAP -0.334790980428701 0.00164827821846065 NA NA NA hsa-miR-454-3p MAPK10 -0.101514866328011 0.843545158256191 0.277853609916948 0.499757905156418 miRNATAP -0.717456429396768 1.33940482149645e-09 NA NA NA hsa-miR-455-5p MAPK10 -0.139599153671262 0.865744220236311 0.277853609916948 0.499757905156418 miRanda -0.270878318986493 0.00909782838990037 NA NA NA hsa-miR-548o-3p MAPK10 -0.191447572716994 0.517725546183501 0.277853609916948 0.499757905156418 mirMAP -0.462430047984935 4.46197714322552e-07 NA NA NA hsa-miR-582-5p MAPK10 -0.399450205475138 0.581227478860085 0.277853609916948 0.499757905156418 PITA -0.605577911431605 1.99297551024098e-08 NA NA NA hsa-miR-590-3p MAPK10 -0.279244755376859 0.59126669933662 0.277853609916948 0.499757905156418 miRanda;mirMAP -0.669311815061267 4.2846409042703e-17 NA NA NA hsa-miR-590-5p MAPK10 -0.547819833829572 0.472735645776647 0.277853609916948 0.499757905156418 PITA;miRanda;miRNATAP -0.775102686172998 6.76449100692106e-21 NA NA NA hsa-miR-935 MAPK10 0.0536667023984385 0.939418255464024 0.277853609916948 0.499757905156418 miRNATAP -0.225220660326491 1.42825991928949e-07 NA NA NA hsa-miR-940 MAPK10 -0.225788347550697 0.680055767105815 0.277853609916948 0.499757905156418 PITA;miRNATAP -0.415226368453551 5.09031496952449e-09 NA NA NA hsa-miR-130a-3p MAPK8 0.0910074087716906 0.929098200371948 -0.319170851710442 0.713899940923572 mirMAP -0.147493968259864 1.00993606990742e-06 NA NA NA hsa-miR-193b-3p MAPK8 0.0672068426635715 0.951480422273678 -0.319170851710442 0.713899940923572 miRNAWalker2_validate -0.106177901094541 0.00010813031062645 NA NA NA hsa-miR-214-3p MAPK8 0.198015895663265 0.797041683257943 -0.319170851710442 0.713899940923572 miRNAWalker2_validate -0.106280310352835 1.00012795110538e-06 19859982 HeLa cells that stably overexpress miR-214 downregulate the expression of MEK3 and JNK1 at both mRNA and protein levels; Further investigation revealed that miR-214 regulates the expression of MEK3 and JNK1 by targeting the 3'UTRs of these genes; Collectively these results suggest that miR-214 negatively regulates HeLa cell proliferation by targeting the noncoding regions of MEK3 and JNK1 mRNAs cervical and endocervical cancer hsa-miR-22-5p MAPK8 -0.0785922550675187 0.93169760098231 -0.319170851710442 0.713899940923572 mirMAP -0.129099178124462 4.99897569863785e-06 NA NA NA hsa-miR-30b-5p MAPK8 -0.0121430518253582 0.994622896704513 -0.319170851710442 0.713899940923572 mirMAP -0.118491315163398 4.11391777534363e-05 NA NA NA hsa-miR-30c-5p MAPK8 -0.298383882401475 0.865809030482001 -0.319170851710442 0.713899940923572 mirMAP -0.136394758639834 0.00107809048076701 NA NA NA hsa-miR-376a-5p MAPK8 0.0978680856849549 0.773217338913054 -0.319170851710442 0.713899940923572 mirMAP -0.102493277664627 6.72583489111155e-05 NA NA NA hsa-miR-495-3p MAPK8 0.00168200867117596 0.997533662527025 -0.319170851710442 0.713899940923572 mirMAP -0.146650526517664 7.87292470161155e-05 NA NA NA hsa-let-7i-5p MAPK9 -0.200792135853451 0.922018647874073 -0.0687722126219112 0.958326759664496 miRNATAP -0.139568596213236 0.00470113649742568 NA NA NA hsa-miR-199a-3p MAPK9 0.0782166873040424 0.973766909565326 -0.0687722126219112 0.958326759664496 miRNAWalker2_validate -0.100016761572209 0.00211211499601589 NA NA NA hsa-miR-411-3p MET 0.067548244516879 0.817862200003413 -0.125950869647744 0.941487193750405 mirMAP -0.145209786605774 0.000849690466844978 NA NA NA hsa-let-7f-5p MRAS 0.048789917034723 0.987280455481631 0.228664941061626 0.758599416375864 mirMAP -0.492725449031154 0.000185736515304168 NA NA NA hsa-let-7g-5p MRAS -0.200947212961157 0.922992045181955 0.228664941061626 0.758599416375864 mirMAP -1.00901869929983 1.68799750465389e-15 NA NA NA hsa-miR-130b-5p MRAS -0.6472141103776 0.379096015222509 0.228664941061626 0.758599416375864 mirMAP -0.657771473971772 1.92628311736042e-17 NA NA NA hsa-miR-135b-5p MRAS 0.631573976263484 0.610028066417462 0.228664941061626 0.758599416375864 miRNATAP -0.272958164095573 9.4502791724407e-08 NA NA NA hsa-miR-15a-5p MRAS -0.0674049094129128 0.964835434214123 0.228664941061626 0.758599416375864 miRNATAP -0.695336092055382 1.78309058388596e-12 NA NA NA hsa-miR-15b-5p MRAS -0.272614787130877 0.87096541832188 0.228664941061626 0.758599416375864 miRNATAP -0.669060159174311 4.18318981262801e-13 NA NA NA hsa-miR-16-5p MRAS 0.0135949734723564 0.994476223855607 0.228664941061626 0.758599416375864 miRNATAP -0.76917023869934 1.25617299958198e-17 NA NA NA hsa-miR-182-5p MRAS -0.104238497940557 0.973380614062243 0.228664941061626 0.758599416375864 miRNATAP -0.393514718321017 1.00181944972084e-07 NA NA NA hsa-miR-26a-1-3p MRAS -0.429875601809349 0.182136384322617 0.228664941061626 0.758599416375864 mirMAP -0.456606496977123 1.17937035699299e-10 NA NA NA hsa-miR-26a-2-3p MRAS -0.427772454814258 0.28776911697575 0.228664941061626 0.758599416375864 mirMAP -0.51846504538519 2.41592479332938e-12 NA NA NA hsa-miR-26b-5p MRAS -0.0245931278499594 0.990377966314923 0.228664941061626 0.758599416375864 miRNATAP -0.806242472983582 1.29060227796861e-13 NA NA NA hsa-miR-29a-3p MRAS 0.01127474410284 0.996977020481272 0.228664941061626 0.758599416375864 mirMAP -0.822593569660772 1.04123018863404e-14 NA NA NA hsa-miR-29a-5p MRAS -0.31835175571979 0.600442757817281 0.228664941061626 0.758599416375864 mirMAP -0.583345753296851 2.48014072431766e-15 NA NA NA hsa-miR-29b-3p MRAS -0.104016192263954 0.958988036765397 0.228664941061626 0.758599416375864 mirMAP -0.669885699152389 3.86125960530788e-17 NA NA NA hsa-miR-30d-3p MRAS -0.123474741320298 0.814905367625791 0.228664941061626 0.758599416375864 mirMAP -0.716400436311934 1.51229106504181e-15 NA NA NA hsa-miR-30e-3p MRAS -0.220498559176349 0.938660731870214 0.228664941061626 0.758599416375864 mirMAP -0.709623434600384 4.97027582039501e-06 NA NA NA hsa-miR-32-3p MRAS -0.568003960723004 0.13133163420273 0.228664941061626 0.758599416375864 mirMAP -0.536378179647598 3.15767201052886e-21 NA NA NA hsa-miR-324-5p MRAS -0.50063248413014 0.537416710557032 0.228664941061626 0.758599416375864 miRanda -0.467136609487543 1.25343979747189e-07 NA NA NA hsa-miR-335-3p MRAS -0.244830745789445 0.88450019116631 0.228664941061626 0.758599416375864 mirMAP -0.595478593731124 4.83540980464014e-16 NA NA NA hsa-miR-33a-3p MRAS -0.794543849238581 0.0105203072007922 0.228664941061626 0.758599416375864 mirMAP -0.447651098777327 1.58787763647451e-10 NA NA NA hsa-miR-362-3p MRAS -0.721040238345347 0.0345881362485733 0.228664941061626 0.758599416375864 miRanda -0.40183739471597 2.87317759911725e-09 NA NA NA hsa-miR-421 MRAS -0.182032017078616 0.734704500318599 0.228664941061626 0.758599416375864 miRanda -0.481606562058004 1.39703136004806e-09 NA NA NA hsa-miR-423-5p MRAS -0.140317642654 0.912448846587903 0.228664941061626 0.758599416375864 miRNATAP -0.448612361455293 1.19435673733541e-05 NA NA NA hsa-miR-424-5p MRAS 0.247080963500746 0.870154571783568 0.228664941061626 0.758599416375864 miRNATAP -0.242227723041348 0.000694464684015509 NA NA NA hsa-miR-429 MRAS -0.456485631615963 0.806240953400535 0.228664941061626 0.758599416375864 miRanda;miRNATAP -0.587690948034785 2.41633231763827e-21 NA NA NA hsa-miR-486-5p MRAS -0.547739229538641 0.696404149927963 0.228664941061626 0.758599416375864 miRanda -0.196533769584679 0.000620313969644355 NA NA NA hsa-miR-582-5p MRAS -0.399450205475138 0.581227478860085 0.228664941061626 0.758599416375864 mirMAP -0.346678237249235 0.000171801104590749 NA NA NA hsa-miR-652-3p MRAS -0.219946355190312 0.860742682824813 0.228664941061626 0.758599416375864 miRNAWalker2_validate -0.46080366073092 7.95303430348797e-07 NA NA NA hsa-miR-7-1-3p MRAS -0.462485777435991 0.665899751398166 0.228664941061626 0.758599416375864 mirMAP -0.6043905775395 2.56909253845426e-14 NA NA NA hsa-miR-96-5p MRAS 0.0854810872029343 0.923087820185031 0.228664941061626 0.758599416375864 TargetScan;miRNATAP -0.580063877289004 2.57556079702539e-17 NA NA NA hsa-miR-98-5p MRAS -0.168162186023221 0.898802461503524 0.228664941061626 0.758599416375864 mirMAP -0.513400316438533 7.69965616214843e-06 NA NA NA hsa-miR-146b-5p NF1 -0.402662509440887 0.837510937985091 0.077091149472758 0.958028470633233 miRanda -0.1325108207471 0.000152007685146501 NA NA NA hsa-miR-495-3p NF1 0.00168200867117596 0.997533662527025 0.077091149472758 0.958028470633233 mirMAP -0.12779647439882 0.00103090091212145 NA NA NA hsa-miR-10a-5p NGFR 0.0740585720685925 0.983770933356406 0.885325062003582 0.109115924574322 mirMAP -0.57553024334957 1.92818293620859e-05 NA NA NA hsa-miR-1275 NGFR -0.831342050607648 0.0803795852164229 0.885325062003582 0.109115924574322 mirMAP -0.287453379390587 0.00128898690353953 NA NA NA hsa-miR-148b-5p NGFR -0.236618793990305 0.43925706879726 0.885325062003582 0.109115924574322 mirMAP -0.797182921842956 2.03014337148425e-10 NA NA NA hsa-miR-15b-3p NGFR -0.557749208157585 0.609181305423188 0.885325062003582 0.109115924574322 mirMAP -1.18491650130189 2.46469294337687e-18 NA NA NA hsa-miR-185-3p NGFR 0.100697585937245 0.856913315942984 0.885325062003582 0.109115924574322 miRNATAP -0.544724292922665 0.000171239589639738 NA NA NA hsa-miR-188-3p NGFR -0.292769686102066 0.475019668859617 0.885325062003582 0.109115924574322 miRNATAP -0.287678324927274 0.00325153363678258 NA NA NA hsa-miR-194-3p NGFR -0.614465699221301 0.733214497063146 0.885325062003582 0.109115924574322 mirMAP -0.940071205248558 6.75747841363716e-18 NA NA NA hsa-miR-2110 NGFR -0.317803483266315 0.250981343062022 0.885325062003582 0.109115924574322 mirMAP -0.491241068229864 0.000339574940265899 NA NA NA hsa-miR-27a-3p NGFR -0.123902317731458 0.958804393510999 0.885325062003582 0.109115924574322 miRNATAP -1.0940953452606 9.94470304770235e-07 NA NA NA hsa-miR-27b-3p NGFR -0.14277121795778 0.951937409841932 0.885325062003582 0.109115924574322 miRNATAP -0.675601576854565 0.00993380464009985 NA NA NA hsa-miR-30b-3p NGFR -0.514644352757504 0.162424853398397 0.885325062003582 0.109115924574322 mirMAP -0.70781693831942 1.60016615876343e-07 NA NA NA hsa-miR-324-5p NGFR -0.50063248413014 0.537416710557032 0.885325062003582 0.109115924574322 miRanda -0.774531921077593 1.24999990242102e-07 NA NA NA hsa-miR-335-5p NGFR -0.0284895175847679 0.973380867832231 0.885325062003582 0.109115924574322 miRNAWalker2_validate -0.582671549958343 5.70354295101825e-06 NA NA NA hsa-miR-34a-5p NGFR -0.50188164870224 0.742034237185732 0.885325062003582 0.109115924574322 mirMAP -0.522596685783366 0.000556195990483505 NA NA NA hsa-miR-429 NGFR -0.456485631615963 0.806240953400535 0.885325062003582 0.109115924574322 miRNATAP -0.906240637466081 3.75014454803432e-18 NA NA NA hsa-miR-539-5p NGFR 0.124342970087029 0.801067485473643 0.885325062003582 0.109115924574322 mirMAP -0.529908329584141 0.000657204445329763 NA NA NA hsa-miR-625-5p NGFR -0.690759472145277 0.210306534567564 0.885325062003582 0.109115924574322 mirMAP -0.638805845344215 2.21297400348686e-10 NA NA NA hsa-miR-760 NGFR -0.669469782471462 0.0773517068284613 0.885325062003582 0.109115924574322 miRNATAP -0.329941574602725 0.000700846491603416 NA NA NA hsa-let-7e-5p NRAS 0.211156073215582 0.922335699862928 -0.124828619880436 0.932579310697412 MirTarget;miRNATAP -0.13435195257722 0.00396667581188335 NA NA NA hsa-miR-221-3p NTF3 0.0906940388127513 0.959121118272534 -0.257089163862745 0.636332266772515 miRNATAP -0.610109014654345 2.67344459535098e-07 NA NA NA hsa-miR-222-3p NTF3 -0.0265849318772702 0.984005474689108 -0.257089163862745 0.636332266772515 miRNATAP -0.52313575472335 8.7686929594132e-07 NA NA NA hsa-miR-335-5p NTF3 -0.0284895175847679 0.973380867832231 -0.257089163862745 0.636332266772515 miRNAWalker2_validate -0.254297552536586 0.00467425364710777 NA NA NA hsa-miR-590-3p NTF3 -0.279244755376859 0.59126669933662 -0.257089163862745 0.636332266772515 miRanda -0.238867138855125 0.00352466395294062 NA NA NA hsa-miR-590-5p NTF3 -0.547819833829572 0.472735645776647 -0.257089163862745 0.636332266772515 PITA;miRanda;miRNATAP -0.282294314485261 0.0010790491435192 NA NA NA hsa-miR-130b-3p NTRK2 -0.221667315324818 0.824660172394714 0.713957410525928 0.344227464503002 mirMAP -0.84860306305913 3.68116891250849e-06 NA NA NA hsa-miR-130b-5p NTRK2 -0.6472141103776 0.379096015222509 0.713957410525928 0.344227464503002 mirMAP -0.818046242261116 2.04435381224772e-06 NA NA NA hsa-miR-148a-5p NTRK2 -0.448099743845604 0.748419139652266 0.713957410525928 0.344227464503002 mirMAP -0.470909045599969 0.00866907323410485 NA NA NA hsa-miR-151a-5p NTRK2 -0.416333535986492 0.695673384848773 0.713957410525928 0.344227464503002 miRNATAP -0.798069900850692 3.15200099909301e-05 NA NA NA hsa-miR-15b-3p NTRK2 -0.557749208157585 0.609181305423188 0.713957410525928 0.344227464503002 mirMAP -1.03701612899491 9.73522451080546e-09 NA NA NA hsa-miR-17-3p NTRK2 0.100221625453134 0.960113387014848 0.713957410525928 0.344227464503002 miRNATAP -0.976533297109227 5.8165830360126e-08 NA NA NA hsa-miR-185-5p NTRK2 -0.294432218239008 0.820591478398594 0.713957410525928 0.344227464503002 mirMAP -0.779623016009143 0.0021334075140637 NA NA NA hsa-miR-186-5p NTRK2 -0.318786974828757 0.85412722938961 0.713957410525928 0.344227464503002 mirMAP -0.957383701195755 0.000144839968612385 NA NA NA hsa-miR-200c-3p NTRK2 -0.437282635857873 0.887118598436407 0.713957410525928 0.344227464503002 miRNAWalker2_validate;miRTarBase -0.6199899985899 0.000602799134319623 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-20a-3p NTRK2 0.456808229166028 0.57674056136504 0.713957410525928 0.344227464503002 mirMAP -0.60033772601526 1.28938210177587e-06 NA NA NA hsa-miR-301a-3p NTRK2 -0.105312511901769 0.831686745977347 0.713957410525928 0.344227464503002 mirMAP -0.59702518092561 0.00012887559022196 NA NA NA hsa-miR-30b-5p NTRK2 -0.0121430518253582 0.994622896704513 0.713957410525928 0.344227464503002 mirMAP -0.518136651655039 0.00350366761608414 NA NA NA hsa-miR-30d-3p NTRK2 -0.123474741320298 0.814905367625791 0.713957410525928 0.344227464503002 mirMAP -0.75947148446546 0.000144661247180184 NA NA NA hsa-miR-32-3p NTRK2 -0.568003960723004 0.13133163420273 0.713957410525928 0.344227464503002 mirMAP -0.393955653385373 0.00254657240224691 NA NA NA hsa-miR-32-5p NTRK2 -0.05993267619119 0.952975951594959 0.713957410525928 0.344227464503002 mirMAP -0.593687529017976 0.00074047888176755 NA NA NA hsa-miR-335-3p NTRK2 -0.244830745789445 0.88450019116631 0.713957410525928 0.344227464503002 mirMAP -0.586164490861426 0.000350559482261675 NA NA NA hsa-miR-33a-5p NTRK2 -0.205788753603336 0.853314500865147 0.713957410525928 0.344227464503002 mirMAP -0.440166951806151 4.80538013717642e-06 NA NA NA hsa-miR-33b-5p NTRK2 -0.161971614375297 0.737436207821109 0.713957410525928 0.344227464503002 mirMAP -0.346053614022834 0.00134849656880221 NA NA NA hsa-miR-369-3p NTRK2 0.116576891957687 0.83230082995912 0.713957410525928 0.344227464503002 mirMAP -0.51441210411069 0.00545821172882658 NA NA NA hsa-miR-374a-5p NTRK2 -0.343007247142618 0.766921280269271 0.713957410525928 0.344227464503002 mirMAP -0.792957457071796 0.00213131427236809 NA NA NA hsa-miR-377-3p NTRK2 -0.0435868040110954 0.893514136702459 0.713957410525928 0.344227464503002 mirMAP -0.469186765032496 0.00325676657980703 NA NA NA hsa-miR-421 NTRK2 -0.182032017078616 0.734704500318599 0.713957410525928 0.344227464503002 mirMAP -0.745837972793792 1.27502759209042e-05 NA NA NA hsa-miR-429 NTRK2 -0.456485631615963 0.806240953400535 0.713957410525928 0.344227464503002 PITA;miRanda;miRNATAP -0.607358789765713 1.69318009529954e-05 NA NA NA hsa-miR-452-3p NTRK2 -0.167134177977311 0.799008246175244 0.713957410525928 0.344227464503002 mirMAP -0.424826514888043 0.000882386795086219 NA NA NA hsa-miR-454-3p NTRK2 -0.101514866328011 0.843545158256191 0.713957410525928 0.344227464503002 mirMAP -1.03687565563906 1.01741231251894e-06 NA NA NA hsa-miR-455-3p NTRK2 -0.356341681711462 0.824635754440661 0.713957410525928 0.344227464503002 mirMAP -0.435834708344416 0.00407925932571666 NA NA NA hsa-miR-501-5p NTRK2 -0.834032628506285 0.0582725160418523 0.713957410525928 0.344227464503002 mirMAP -0.388955969272554 0.00376398178826822 NA NA NA hsa-miR-576-5p NTRK2 -0.506413219377403 0.417187951364173 0.713957410525928 0.344227464503002 PITA;mirMAP -0.620750548380737 0.000573279730246138 NA NA NA hsa-miR-577 NTRK2 -1.06238199218774 0.326056761787754 0.713957410525928 0.344227464503002 mirMAP -0.394769227040369 2.13251966281415e-05 NA NA NA hsa-miR-590-3p NTRK2 -0.279244755376859 0.59126669933662 0.713957410525928 0.344227464503002 PITA;miRanda;mirMAP -0.650284146592079 1.26751543217643e-05 NA NA NA hsa-miR-590-5p NTRK2 -0.547819833829572 0.472735645776647 0.713957410525928 0.344227464503002 miRanda;mirMAP -0.801561087461349 2.88717365367254e-07 NA NA NA hsa-miR-760 NTRK2 -0.669469782471462 0.0773517068284613 0.713957410525928 0.344227464503002 PITA;miRNATAP -0.320637386396562 0.00994890145462774 NA NA NA hsa-miR-940 NTRK2 -0.225788347550697 0.680055767105815 0.713957410525928 0.344227464503002 PITA -0.53900674685054 2.49123954783046e-05 NA NA NA hsa-let-7c-5p PAK4 -0.0629831812743404 0.974895834249241 0.0670878952045015 0.964147734774563 miRNAWalker2_validate -0.105996399764865 5.93870998856013e-06 NA NA NA hsa-miR-331-5p PDGFA -0.450673082073933 0.250361590873666 0.322821100258507 0.767865638706571 PITA;miRNATAP -0.263950239852047 0.000506838266187203 NA NA NA hsa-let-7d-5p PDGFB -0.139747701175051 0.934164162708487 0.313242927790498 0.743141773305227 miRNATAP -0.35910919131 0.000104487041240393 NA NA NA hsa-let-7f-5p PDGFB 0.048789917034723 0.987280455481631 0.313242927790498 0.743141773305227 miRNATAP -0.244280289349921 0.00604928509607363 NA NA NA hsa-let-7g-5p PDGFB -0.200947212961157 0.922992045181955 0.313242927790498 0.743141773305227 miRNATAP -0.480991322593709 4.82276901946855e-08 NA NA NA hsa-miR-17-5p PDGFB -0.175448849583061 0.934544015912731 0.313242927790498 0.743141773305227 TargetScan -0.259524570506942 1.31684333799908e-07 NA NA NA hsa-miR-18a-3p PDGFB -0.270443061178857 0.535291623032886 0.313242927790498 0.743141773305227 MirTarget -0.122279258136473 0.00341292486566504 NA NA NA hsa-miR-26b-5p PDGFB -0.0245931278499594 0.990377966314923 0.313242927790498 0.743141773305227 miRNAWalker2_validate -0.347387618826242 4.49913892640547e-06 NA NA NA hsa-miR-29a-3p PDGFB 0.01127474410284 0.996977020481272 0.313242927790498 0.743141773305227 MirTarget;miRNATAP -0.288293585647454 0.000119375011677654 NA NA NA hsa-miR-29b-3p PDGFB -0.104016192263954 0.958988036765397 0.313242927790498 0.743141773305227 MirTarget;miRNATAP -0.241085738055695 2.00161076900261e-05 NA NA NA hsa-miR-335-5p PDGFB -0.0284895175847679 0.973380867832231 0.313242927790498 0.743141773305227 mirMAP -0.290025221620047 1.51950551363649e-08 NA NA NA hsa-miR-362-3p PDGFB -0.721040238345347 0.0345881362485733 0.313242927790498 0.743141773305227 miRanda -0.15824200229485 0.000678732510299074 NA NA NA hsa-miR-590-3p PDGFB -0.279244755376859 0.59126669933662 0.313242927790498 0.743141773305227 PITA;miRanda;miRNATAP -0.253879073321591 5.92294321424903e-08 NA NA NA hsa-let-7a-3p PDGFC -0.215598045625677 0.85543299203799 0.414252063165922 0.616833473868723 mirMAP -0.560183588702006 8.86071239448277e-09 NA NA NA hsa-let-7f-1-3p PDGFC -0.31101436822914 0.693407210545374 0.414252063165922 0.616833473868723 mirMAP -0.703978074740073 1.42987121597363e-07 NA NA NA hsa-miR-142-5p PDGFC -0.118920788314118 0.929665277963083 0.414252063165922 0.616833473868723 PITA -0.305943205742333 0.000155995351628435 NA NA NA hsa-miR-16-2-3p PDGFC -0.36717860153421 0.546850726070016 0.414252063165922 0.616833473868723 mirMAP -0.645615500315815 8.74884490838483e-17 NA NA NA hsa-miR-335-3p PDGFC -0.244830745789445 0.88450019116631 0.414252063165922 0.616833473868723 mirMAP -0.427906675686462 1.13976939151158e-07 NA NA NA hsa-miR-340-5p PDGFC -0.00276909425328853 0.99757361161055 0.414252063165922 0.616833473868723 mirMAP -0.317325095486823 0.00272400287013771 NA NA NA hsa-miR-361-5p PDGFC -0.138735309928775 0.941495130308343 0.414252063165922 0.616833473868723 miRanda -0.400399039684502 0.00909721956142468 NA NA NA hsa-miR-374a-3p PDGFC -0.118320910531011 0.958176637009264 0.414252063165922 0.616833473868723 mirMAP -0.298503375227624 0.000932648117099459 NA NA NA hsa-miR-375 PDGFC -0.690952835064582 0.831716365337668 0.414252063165922 0.616833473868723 miRNAWalker2_validate;miRanda -0.245562483628609 1.4753224001304e-05 NA NA NA hsa-miR-421 PDGFC -0.182032017078616 0.734704500318599 0.414252063165922 0.616833473868723 miRanda -0.371118134754982 1.45046027428591e-05 NA NA NA hsa-miR-486-5p PDGFC -0.547739229538641 0.696404149927963 0.414252063165922 0.616833473868723 miRanda -0.212861950777362 0.000436948085668591 NA NA NA hsa-miR-582-3p PDGFC -0.2334649592375 0.897678119160318 0.414252063165922 0.616833473868723 PITA -0.419807549483108 6.92645904555322e-06 NA NA NA hsa-miR-590-3p PDGFC -0.279244755376859 0.59126669933662 0.414252063165922 0.616833473868723 PITA;miRanda;mirMAP -0.622498782062005 4.5648477200687e-19 NA NA NA hsa-miR-7-1-3p PDGFC -0.462485777435991 0.665899751398166 0.414252063165922 0.616833473868723 mirMAP -0.683487588802839 1.48003343394682e-16 NA NA NA hsa-miR-7-5p PDGFC 0.209645143210379 0.773705612298441 0.414252063165922 0.616833473868723 miRNAWalker2_validate -0.355404199624497 6.53479001104984e-11 NA NA NA hsa-miR-125a-3p PDGFD 0.14689780893708 0.724764670752407 0.373704891557837 0.506977322141266 miRanda -0.301240683905164 3.81965160075026e-06 NA NA NA hsa-miR-19b-1-5p PDGFD -0.0105982583216702 0.988511655226679 0.373704891557837 0.506977322141266 MirTarget -0.345717271489925 5.0328296726647e-06 NA NA NA hsa-miR-203a-3p PDGFD -0.265248086637561 0.931593594361942 0.373704891557837 0.506977322141266 MirTarget -0.189899712371588 0.00217128481212937 NA NA NA hsa-miR-320b PDGFD -0.23561798088153 0.859222532827992 0.373704891557837 0.506977322141266 miRanda -0.281894373378923 0.00152966341011458 NA NA NA hsa-miR-331-5p PDGFD -0.450673082073933 0.250361590873666 0.373704891557837 0.506977322141266 MirTarget -0.45954324857632 4.49931356687149e-07 NA NA NA hsa-miR-374b-5p PDGFD -0.285682091626878 0.83569830479965 0.373704891557837 0.506977322141266 MirTarget;mirMAP -0.319164107426016 0.00577840952856108 NA NA NA hsa-miR-590-3p PDGFD -0.279244755376859 0.59126669933662 0.373704891557837 0.506977322141266 miRanda;mirMAP;miRNATAP -0.385624849353768 1.19268414995478e-08 NA NA NA hsa-miR-590-5p PDGFD -0.547819833829572 0.472735645776647 0.373704891557837 0.506977322141266 miRanda -0.481631209595548 7.86360288880717e-12 NA NA NA hsa-miR-7-1-3p PDGFD -0.462485777435991 0.665899751398166 0.373704891557837 0.506977322141266 mirMAP -0.439118502606612 3.23826516590321e-08 NA NA NA hsa-let-7a-3p PDGFRA -0.215598045625677 0.85543299203799 -0.145858107393819 0.902950557320272 mirMAP -0.46804730928802 1.13954952980613e-05 NA NA NA hsa-let-7f-1-3p PDGFRA -0.31101436822914 0.693407210545374 -0.145858107393819 0.902950557320272 mirMAP -0.516833762443087 0.000428514669277019 NA NA NA hsa-let-7g-3p PDGFRA -0.489638373791485 0.62941522205833 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.448281873669985 3.34960551496113e-08 NA NA NA hsa-miR-106a-5p PDGFRA -0.203919267842652 0.802213958426804 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.461331612749808 1.21459582544494e-06 NA NA NA hsa-miR-106b-5p PDGFRA -0.297128724729339 0.869294443540749 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.788405389096865 1.19973361815904e-13 NA NA NA hsa-miR-130b-3p PDGFRA -0.221667315324818 0.824660172394714 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.713055953049172 6.98352333830201e-14 NA NA NA hsa-miR-140-5p PDGFRA -0.229213026275906 0.847330111738616 -0.145858107393819 0.902950557320272 miRNAWalker2_validate;miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.378645948787408 0.00817849787504184 26297547 miR 140 5p inhibits ovarian cancer growth partially by repression of PDGFRA; Additionally PDGFRA was predicted the target gene of miR-140-5p; PDGFRA was inversely correlated with the expression of miR-140-5p in ovarian cancer cells ovarian cancer hsa-miR-141-3p PDGFRA -0.31994058840327 0.87774106909065 -0.145858107393819 0.902950557320272 MirTarget -0.558254342811311 1.59735147532957e-12 NA NA NA hsa-miR-16-1-3p PDGFRA 0.151694812889216 0.733736501874638 -0.145858107393819 0.902950557320272 MirTarget -0.391474995802884 3.72447068651333e-06 NA NA NA hsa-miR-17-5p PDGFRA -0.175448849583061 0.934544015912731 -0.145858107393819 0.902950557320272 MirTarget;TargetScan;miRNATAP -0.500899724208041 1.35275307087739e-09 NA NA NA hsa-miR-182-5p PDGFRA -0.104238497940557 0.973380614062243 -0.145858107393819 0.902950557320272 miRNATAP -0.351343598684222 3.64495302642716e-05 NA NA NA hsa-miR-186-5p PDGFRA -0.318786974828757 0.85412722938961 -0.145858107393819 0.902950557320272 MirTarget -0.680532199603127 4.02581457439773e-07 NA NA NA hsa-miR-193a-3p PDGFRA -0.247265785363732 0.654363581941634 -0.145858107393819 0.902950557320272 miRanda -0.308129712347872 0.000729810331533374 NA NA NA hsa-miR-196a-5p PDGFRA -0.0569856738232488 0.973093117800687 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.226717073924458 7.8971760883461e-05 NA NA NA hsa-miR-200a-3p PDGFRA -0.367034437440907 0.851059894150266 -0.145858107393819 0.902950557320272 MirTarget -0.414102446036165 1.51743336403368e-07 NA NA NA hsa-miR-20a-5p PDGFRA -0.179153323927949 0.928118119139752 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.403163295382866 1.05772983131811e-06 NA NA NA hsa-miR-2110 PDGFRA -0.317803483266315 0.250981343062022 -0.145858107393819 0.902950557320272 MirTarget -0.366181032284536 9.44460298164708e-05 NA NA NA hsa-miR-26b-5p PDGFRA -0.0245931278499594 0.990377966314923 -0.145858107393819 0.902950557320272 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.76554214258799 1.34342011356511e-09 NA NA NA hsa-miR-27a-3p PDGFRA -0.123902317731458 0.958804393510999 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.516042216303154 0.000914778337518972 NA NA NA hsa-miR-29a-3p PDGFRA 0.01127474410284 0.996977020481272 -0.145858107393819 0.902950557320272 MirTarget -0.809568799779591 4.96242330696496e-11 NA NA NA hsa-miR-29b-1-5p PDGFRA -0.642348119412534 0.293891497238796 -0.145858107393819 0.902950557320272 mirMAP -0.425193514964668 2.19115837746288e-10 NA NA NA hsa-miR-29b-3p PDGFRA -0.104016192263954 0.958988036765397 -0.145858107393819 0.902950557320272 MirTarget -0.70477380352231 1.49237333469501e-14 NA NA NA hsa-miR-301a-3p PDGFRA -0.105312511901769 0.831686745977347 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.397818747734378 1.84518884433226e-06 NA NA NA hsa-miR-320b PDGFRA -0.23561798088153 0.859222532827992 -0.145858107393819 0.902950557320272 miRanda -0.271817768499418 0.00931638762599068 NA NA NA hsa-miR-335-3p PDGFRA -0.244830745789445 0.88450019116631 -0.145858107393819 0.902950557320272 mirMAP -0.35160587390058 6.70186373595121e-05 NA NA NA hsa-miR-339-5p PDGFRA -0.300425087100667 0.712912847076788 -0.145858107393819 0.902950557320272 miRanda -0.457485269989944 3.66341806935034e-09 NA NA NA hsa-miR-33a-5p PDGFRA -0.205788753603336 0.853314500865147 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.272405442549699 1.25878366881518e-07 NA NA NA hsa-miR-33b-5p PDGFRA -0.161971614375297 0.737436207821109 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.351193123166394 4.89573526569498e-10 NA NA NA hsa-miR-34a-5p PDGFRA -0.50188164870224 0.742034237185732 -0.145858107393819 0.902950557320272 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.293946617803388 0.00483203526840856 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-362-3p PDGFRA -0.721040238345347 0.0345881362485733 -0.145858107393819 0.902950557320272 miRanda -0.331137641396915 2.44365531587286e-05 NA NA NA hsa-miR-374b-5p PDGFRA -0.285682091626878 0.83569830479965 -0.145858107393819 0.902950557320272 mirMAP -0.489332532273884 0.000275322473260306 NA NA NA hsa-miR-421 PDGFRA -0.182032017078616 0.734704500318599 -0.145858107393819 0.902950557320272 PITA;miRanda;miRNATAP -0.331972101032041 0.000352331324069819 NA NA NA hsa-miR-429 PDGFRA -0.456485631615963 0.806240953400535 -0.145858107393819 0.902950557320272 miRanda;miRNATAP -0.427308243384876 1.22907424761067e-08 NA NA NA hsa-miR-454-3p PDGFRA -0.101514866328011 0.843545158256191 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.526182378920795 4.63430277666318e-06 NA NA NA hsa-miR-550a-5p PDGFRA -0.390865630073894 0.535659273352227 -0.145858107393819 0.902950557320272 MirTarget -0.303957080101116 0.000421501403265132 NA NA NA hsa-miR-576-5p PDGFRA -0.506413219377403 0.417187951364173 -0.145858107393819 0.902950557320272 mirMAP -0.53161391653101 2.34508916321778e-08 NA NA NA hsa-miR-589-3p PDGFRA -0.835836305204965 0.0112001563801511 -0.145858107393819 0.902950557320272 mirMAP -0.324416945059502 1.4854980540892e-05 NA NA NA hsa-miR-590-3p PDGFRA -0.279244755376859 0.59126669933662 -0.145858107393819 0.902950557320272 miRanda;mirMAP -0.505584545520693 1.12850394310824e-10 NA NA NA hsa-miR-590-5p PDGFRA -0.547819833829572 0.472735645776647 -0.145858107393819 0.902950557320272 miRanda -0.618116353853085 3.24347610137224e-14 NA NA NA hsa-miR-642a-5p PDGFRA 0.00605485088835034 0.98806034007652 -0.145858107393819 0.902950557320272 MirTarget -0.215832054890106 0.000746473138697964 NA NA NA hsa-miR-7-1-3p PDGFRA -0.462485777435991 0.665899751398166 -0.145858107393819 0.902950557320272 mirMAP -0.523812035758304 1.699078163408e-08 NA NA NA hsa-miR-93-5p PDGFRA -0.611073677204699 0.825297877093193 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.562179024434523 5.29517125454282e-08 NA NA NA hsa-miR-96-5p PDGFRA 0.0854810872029343 0.923087820185031 -0.145858107393819 0.902950557320272 TargetScan;miRNATAP -0.531895407762512 3.58063096797815e-11 NA NA NA hsa-miR-224-5p PDGFRB -0.240425158977724 0.857351098476517 0.269735385981489 0.859643412257275 miRNAWalker2_validate -0.167596299133301 0.00451959282563429 NA NA NA hsa-miR-24-3p PDGFRB -0.0484778924256624 0.985274054814493 0.269735385981489 0.859643412257275 MirTarget -0.497348994016324 0.00212455415626555 NA NA NA hsa-miR-29a-3p PDGFRB 0.01127474410284 0.996977020481272 0.269735385981489 0.859643412257275 miRNATAP -0.749182849370106 8.28046458679609e-14 NA NA NA hsa-miR-29b-3p PDGFRB -0.104016192263954 0.958988036765397 0.269735385981489 0.859643412257275 miRNATAP -0.585510495081087 9.96403642896333e-15 NA NA NA hsa-miR-421 PDGFRB -0.182032017078616 0.734704500318599 0.269735385981489 0.859643412257275 miRanda -0.362666739511917 1.74841862274672e-06 NA NA NA hsa-miR-484 PDGFRB -0.179977202691249 0.886333755572375 0.269735385981489 0.859643412257275 mirMAP -0.538053678604706 4.36179283359931e-08 NA NA NA hsa-miR-429 PGF -0.456485631615963 0.806240953400535 0.246821616713936 0.742062581671624 miRNATAP -0.157730468642131 0.00280494441192971 NA NA NA hsa-let-7f-1-3p PIK3CA -0.31101436822914 0.693407210545374 0.0225357621933919 0.979422693316883 mirMAP -0.118501081655342 0.0064771514178073 NA NA NA hsa-miR-148a-5p PIK3CA -0.448099743845604 0.748419139652266 0.0225357621933919 0.979422693316883 mirMAP -0.112357517651492 7.06215647986463e-05 NA NA NA hsa-miR-148b-3p PIK3CA -0.202106692287125 0.911884960581838 0.0225357621933919 0.979422693316883 miRNAWalker2_validate -0.117892096365902 0.00490902202717801 NA NA NA hsa-miR-16-2-3p PIK3CA -0.36717860153421 0.546850726070016 0.0225357621933919 0.979422693316883 mirMAP -0.10245614796563 9.13897985797286e-05 NA NA NA hsa-miR-17-5p PIK3CA -0.175448849583061 0.934544015912731 0.0225357621933919 0.979422693316883 miRNAWalker2_validate -0.115705723770344 3.03228335548689e-06 NA NA NA hsa-miR-186-5p PIK3CA -0.318786974828757 0.85412722938961 0.0225357621933919 0.979422693316883 mirMAP -0.146329134056921 0.000268937701971312 NA NA NA hsa-miR-32-3p PIK3CA -0.568003960723004 0.13133163420273 0.0225357621933919 0.979422693316883 mirMAP -0.112972746252127 2.51225612643757e-08 NA NA NA hsa-miR-335-5p PIK3CA -0.0284895175847679 0.973380867832231 0.0225357621933919 0.979422693316883 miRNAWalker2_validate -0.10180509768488 9.82755134026126e-05 NA NA NA hsa-miR-339-5p PIK3CA -0.300425087100667 0.712912847076788 0.0225357621933919 0.979422693316883 miRanda -0.103587269763801 8.44655068921029e-06 NA NA NA hsa-miR-374b-5p PIK3CA -0.285682091626878 0.83569830479965 0.0225357621933919 0.979422693316883 mirMAP -0.142766383581644 0.00032150800529493 NA NA NA hsa-miR-501-5p PIK3CA -0.834032628506285 0.0582725160418523 0.0225357621933919 0.979422693316883 mirMAP -0.110757579310586 1.16330645525834e-07 NA NA NA hsa-miR-576-5p PIK3CA -0.506413219377403 0.417187951364173 0.0225357621933919 0.979422693316883 PITA -0.113974010997229 6.59094941020168e-05 NA NA NA hsa-miR-582-3p PIK3CA -0.2334649592375 0.897678119160318 0.0225357621933919 0.979422693316883 miRNATAP -0.140113361530972 2.23178585157338e-06 NA NA NA hsa-miR-590-3p PIK3CA -0.279244755376859 0.59126669933662 0.0225357621933919 0.979422693316883 miRanda;mirMAP -0.123897140594567 1.31301452772078e-07 NA NA NA hsa-miR-590-5p PIK3CA -0.547819833829572 0.472735645776647 0.0225357621933919 0.979422693316883 miRanda -0.140125048782077 1.41706046141534e-08 NA NA NA hsa-miR-96-5p PIK3CA 0.0854810872029343 0.923087820185031 0.0225357621933919 0.979422693316883 TargetScan -0.128475980855667 9.81905908048452e-08 NA NA NA hsa-miR-1468-5p PIK3CD -0.200868572236891 0.688408103178562 -0.0499659666229988 0.947033498136668 MirTarget -0.293090508926218 0.000248785469894942 NA NA NA hsa-miR-29a-3p PIK3CD 0.01127474410284 0.996977020481272 -0.0499659666229988 0.947033498136668 mirMAP -0.351166771873915 0.00243536234086878 NA NA NA hsa-miR-29b-3p PIK3CD -0.104016192263954 0.958988036765397 -0.0499659666229988 0.947033498136668 mirMAP -0.263613715224296 0.00266331795083224 NA NA NA hsa-miR-30b-5p PIK3CD -0.0121430518253582 0.994622896704513 -0.0499659666229988 0.947033498136668 MirTarget -0.395682674717868 3.65190942130723e-06 NA NA NA hsa-miR-30c-5p PIK3CD -0.298383882401475 0.865809030482001 -0.0499659666229988 0.947033498136668 MirTarget;miRNATAP -0.419452305097446 0.000712699686404817 NA NA NA hsa-miR-30d-5p PIK3CD -0.168211838771867 0.95173197030375 -0.0499659666229988 0.947033498136668 MirTarget;miRNATAP -0.360885227262785 0.00123008895505406 NA NA NA hsa-miR-421 PIK3CD -0.182032017078616 0.734704500318599 -0.0499659666229988 0.947033498136668 miRanda -0.48895286723391 2.44692621373687e-09 NA NA NA hsa-miR-484 PIK3CD -0.179977202691249 0.886333755572375 -0.0499659666229988 0.947033498136668 MirTarget;miRNATAP -0.351057480112147 0.00143452196121959 NA NA NA hsa-miR-7-5p PIK3CD 0.209645143210379 0.773705612298441 -0.0499659666229988 0.947033498136668 miRTarBase;MirTarget;miRNATAP -0.196228010352377 0.000352590199023202 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway liver cancer hsa-miR-942-5p PIK3CD -0.50502396741886 0.50777904281306 -0.0499659666229988 0.947033498136668 MirTarget -0.192312219113083 0.0086308226579878 NA NA NA hsa-miR-132-3p PIK3R1 -0.244143673573889 0.871752726220643 -0.107670470040419 0.937523599303491 MirTarget -0.191363026291576 0.00729852053203983 NA NA NA hsa-miR-15a-5p PIK3R1 -0.0674049094129128 0.964835434214123 -0.107670470040419 0.937523599303491 MirTarget -0.217108462406312 8.91731617861317e-05 NA NA NA hsa-miR-15b-5p PIK3R1 -0.272614787130877 0.87096541832188 -0.107670470040419 0.937523599303491 MirTarget -0.14300320532504 0.00643583854060318 NA NA NA hsa-miR-16-5p PIK3R1 0.0135949734723564 0.994476223855607 -0.107670470040419 0.937523599303491 MirTarget -0.189731088951203 0.0002621971143127 NA NA NA hsa-miR-185-5p PIK3R1 -0.294432218239008 0.820591478398594 -0.107670470040419 0.937523599303491 miRNATAP -0.23627908813405 0.00027005032337405 NA NA NA hsa-miR-21-5p PIK3R1 -0.148920887107433 0.970240620972126 -0.107670470040419 0.937523599303491 miRNAWalker2_validate;MirTarget;miRNATAP -0.32048586087571 3.69693869528844e-05 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 -0.0224067199236484 0.973232008101458 -0.107670470040419 0.937523599303491 MirTarget -0.229364822725893 5.39528810633945e-05 NA NA NA hsa-miR-22-5p PIK3R1 -0.0785922550675187 0.93169760098231 -0.107670470040419 0.937523599303491 mirMAP -0.186145388676108 2.66965799007355e-05 NA NA NA hsa-miR-221-3p PIK3R1 0.0906940388127513 0.959121118272534 -0.107670470040419 0.937523599303491 MirTarget -0.197435928682178 0.000527618156345501 NA NA NA hsa-miR-222-3p PIK3R1 -0.0265849318772702 0.984005474689108 -0.107670470040419 0.937523599303491 MirTarget -0.202803725155249 6.41878654683067e-05 NA NA NA hsa-miR-369-3p PIK3R1 0.116576891957687 0.83230082995912 -0.107670470040419 0.937523599303491 PITA -0.167895129809982 0.000380018195201003 NA NA NA hsa-miR-424-5p PIK3R1 0.247080963500746 0.870154571783568 -0.107670470040419 0.937523599303491 MirTarget -0.119382000204097 0.00203768025896863 NA NA NA hsa-miR-450b-5p PIK3R1 -0.0136687538973108 0.983149761399849 -0.107670470040419 0.937523599303491 miRNATAP -0.190787246019265 6.82791616588e-05 NA NA NA hsa-miR-542-3p PIK3R1 0.188168046511374 0.909252939431573 -0.107670470040419 0.937523599303491 MirTarget;PITA;miRanda -0.150969723974234 0.00748950466389255 NA NA NA hsa-miR-582-5p PIK3R1 -0.399450205475138 0.581227478860085 -0.107670470040419 0.937523599303491 mirMAP -0.142451077115944 0.0045721005781701 NA NA NA hsa-miR-590-3p PIK3R1 -0.279244755376859 0.59126669933662 -0.107670470040419 0.937523599303491 miRanda;mirMAP -0.146401290926594 0.000138874186663878 NA NA NA hsa-miR-590-5p PIK3R1 -0.547819833829572 0.472735645776647 -0.107670470040419 0.937523599303491 MirTarget;PITA;miRanda;miRNATAP -0.15721405103923 0.000108223764424085 NA NA NA hsa-miR-30a-5p PIK3R2 0.219472325612346 0.933954023293816 -0.297680606771329 0.850152230341952 miRNATAP -0.205862820761505 5.83465711487357e-06 NA NA NA hsa-miR-181c-5p PIK3R3 0.042951891660695 0.969159991881861 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.166375015135553 0.00307339705460455 NA NA NA hsa-miR-181d-5p PIK3R3 0.14926527647499 0.888000971478017 -0.276772749610974 0.793454902449853 MirTarget -0.160008098502222 0.000261018045617695 NA NA NA hsa-miR-19a-3p PIK3R3 -0.206793507801887 0.844637784802316 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.116147528359031 0.00952170048888319 NA NA NA hsa-miR-19b-3p PIK3R3 -0.0268530183621474 0.986656783046572 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.194729521448902 0.000250390771046988 NA NA NA hsa-miR-32-5p PIK3R3 -0.05993267619119 0.952975951594959 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.138065839958076 0.00869251602983598 NA NA NA hsa-miR-335-3p PIK3R3 -0.244830745789445 0.88450019116631 -0.276772749610974 0.793454902449853 mirMAP -0.200911178812086 3.4951167686824e-05 NA NA NA hsa-miR-339-5p PIK3R3 -0.300425087100667 0.712912847076788 -0.276772749610974 0.793454902449853 MirTarget;miRanda -0.114440753951127 0.00949514702310638 NA NA NA hsa-miR-454-3p PIK3R3 -0.101514866328011 0.843545158256191 -0.276772749610974 0.793454902449853 mirMAP -0.183582040707033 0.00426750044797469 NA NA NA hsa-miR-92a-3p PIK3R3 0.0278830870766349 0.993247426671713 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.264671393069774 1.12229021521678e-06 NA NA NA hsa-miR-324-5p PLA1A -0.50063248413014 0.537416710557032 0.595412688812886 0.321769379965996 miRanda -0.423321290047031 0.000815605408232031 NA NA NA hsa-miR-486-5p PLA1A -0.547739229538641 0.696404149927963 0.595412688812886 0.321769379965996 miRanda -0.209403692908177 0.00981542505686197 NA NA NA hsa-miR-361-5p PLA2G2A -0.138735309928775 0.941495130308343 -0.893929415091853 0.558555484830263 miRanda -1.88892274433189 8.28724293014527e-07 NA NA NA hsa-miR-542-3p PLA2G2D 0.188168046511374 0.909252939431573 -0.568038143383523 0.451587568296858 mirMAP -0.710465301036333 0.00357884264533144 NA NA NA hsa-miR-335-5p PLA2G2F -0.0284895175847679 0.973380867832231 0.308872685548984 0.755109764116244 mirMAP -0.509123839894343 0.00467705099258117 NA NA NA hsa-miR-452-3p PLA2G3 -0.167134177977311 0.799008246175244 -1.01702523712827 0.30431111054657 MirTarget -0.505412307982113 0.00504840689182451 NA NA NA hsa-miR-98-5p PLA2G3 -0.168162186023221 0.898802461503524 -1.01702523712827 0.30431111054657 MirTarget -0.899412333243839 0.00914875866125122 NA NA NA hsa-miR-181c-5p PLA2G4A 0.042951891660695 0.969159991881861 -0.17795678003461 0.817238494646462 MirTarget -0.578532695174483 0.000615603310862364 NA NA NA hsa-miR-181d-5p PLA2G4A 0.14926527647499 0.888000971478017 -0.17795678003461 0.817238494646462 MirTarget -0.564246660185543 1.7559415649798e-05 NA NA NA hsa-miR-361-5p PLA2G4A -0.138735309928775 0.941495130308343 -0.17795678003461 0.817238494646462 miRanda -1.29289456265609 1.70051078235766e-06 NA NA NA hsa-miR-362-3p PLA2G4A -0.721040238345347 0.0345881362485733 -0.17795678003461 0.817238494646462 miRanda -0.387724288667359 0.00326532186695987 NA NA NA hsa-miR-374a-5p PLA2G4A -0.343007247142618 0.766921280269271 -0.17795678003461 0.817238494646462 mirMAP -1.25811294976854 2.63713185547972e-08 NA NA NA hsa-miR-374b-5p PLA2G4A -0.285682091626878 0.83569830479965 -0.17795678003461 0.817238494646462 mirMAP -1.09437721975642 7.17405856968019e-07 NA NA NA hsa-miR-107 PLA2G4C -0.0365118169251648 0.988364120226869 0.121796393295618 0.818946806290777 miRanda -0.461941533942191 0.00201102649929904 NA NA NA hsa-miR-128-3p PLA2G5 -0.442192625156042 0.783886533572187 0.437718131121004 0.388965933347537 miRNAWalker2_validate -1.07299221212294 1.5853171740956e-12 NA NA NA hsa-miR-330-5p PLA2G5 -0.283418953659271 0.815687101334695 0.437718131121004 0.388965933347537 miRanda -0.482332053855329 0.00283741833706521 NA NA NA hsa-miR-339-5p PLA2G5 -0.300425087100667 0.712912847076788 0.437718131121004 0.388965933347537 miRanda -0.568708478983702 7.27136745248125e-09 NA NA NA hsa-miR-361-5p PLA2G5 -0.138735309928775 0.941495130308343 0.437718131121004 0.388965933347537 miRanda -0.730869197957008 0.000446179208994754 NA NA NA hsa-miR-429 PLA2G5 -0.456485631615963 0.806240953400535 0.437718131121004 0.388965933347537 miRanda -0.864714773103646 1.88119901673923e-22 NA NA NA hsa-miR-589-3p PLA2G5 -0.835836305204965 0.0112001563801511 0.437718131121004 0.388965933347537 MirTarget -0.558011063524848 1.97396961165042e-09 NA NA NA hsa-miR-590-3p PLA2G5 -0.279244755376859 0.59126669933662 0.437718131121004 0.388965933347537 miRanda;miRNATAP -0.845281063909192 7.33272044028014e-19 NA NA NA hsa-miR-590-5p PLA2G5 -0.547819833829572 0.472735645776647 0.437718131121004 0.388965933347537 miRanda -0.89773159614219 4.81957599780374e-19 NA NA NA hsa-miR-30a-3p PLA2G6 0.250338313897394 0.917094926793447 -0.0643225595335317 0.939085094960597 miRNATAP -0.180417635243828 0.00653370893089679 NA NA NA hsa-miR-335-5p PLCG2 -0.0284895175847679 0.973380867832231 0.401721432838585 0.577817975563816 miRNAWalker2_validate -0.513269839343922 3.35983478983679e-09 NA NA NA hsa-miR-590-3p PLCG2 -0.279244755376859 0.59126669933662 0.401721432838585 0.577817975563816 miRanda -0.308699554904666 0.000136379214988007 NA NA NA hsa-miR-126-5p PRKACB 0.0815213541035824 0.956637332055185 0.143826955266481 0.908097519021419 mirMAP -0.368751851213397 0.00120348231579359 NA NA NA hsa-miR-146b-5p PRKACB -0.402662509440887 0.837510937985091 0.143826955266481 0.908097519021419 miRanda -0.384839282045274 0.000123624033577825 NA NA NA hsa-miR-16-2-3p PRKACB -0.36717860153421 0.546850726070016 0.143826955266481 0.908097519021419 mirMAP -0.327254668787011 5.02396526650647e-05 NA NA NA hsa-miR-18a-5p PRKACB -0.498318455303917 0.61264091975585 0.143826955266481 0.908097519021419 miRNATAP -0.245987058818593 0.000136929122339416 NA NA NA hsa-miR-18b-5p PRKACB -0.0473300652227538 0.899981261531446 0.143826955266481 0.908097519021419 miRNATAP -0.219595347623136 0.000526621294339559 NA NA NA hsa-miR-19a-3p PRKACB -0.206793507801887 0.844637784802316 0.143826955266481 0.908097519021419 MirTarget;miRNATAP -0.207051001728292 0.00506627328237604 NA NA NA hsa-miR-32-3p PRKACB -0.568003960723004 0.13133163420273 0.143826955266481 0.908097519021419 mirMAP;miRNATAP -0.203540155235648 0.00148647674126439 NA NA NA hsa-miR-577 PRKACB -1.06238199218774 0.326056761787754 0.143826955266481 0.908097519021419 PITA -0.156719343600752 0.000649809465517546 NA NA NA hsa-miR-582-5p PRKACB -0.399450205475138 0.581227478860085 0.143826955266481 0.908097519021419 MirTarget;PITA;miRNATAP -0.435642871850008 4.26493780643228e-06 NA NA NA hsa-miR-590-3p PRKACB -0.279244755376859 0.59126669933662 0.143826955266481 0.908097519021419 MirTarget;PITA;miRanda;miRNATAP -0.287824756359109 8.97202997356946e-05 NA NA NA hsa-miR-590-5p PRKACB -0.547819833829572 0.472735645776647 0.143826955266481 0.908097519021419 miRanda -0.269757804036837 0.000543621862271192 NA NA NA hsa-miR-7-1-3p PRKACB -0.462485777435991 0.665899751398166 0.143826955266481 0.908097519021419 mirMAP -0.347600791347028 5.3123112509601e-05 NA NA NA hsa-miR-29a-5p PRKCA -0.31835175571979 0.600442757817281 0.0560239871270882 0.96439442241644 mirMAP -0.131495002018621 0.00519611005738431 NA NA NA hsa-miR-450b-5p PRKCA -0.0136687538973108 0.983149761399849 0.0560239871270882 0.96439442241644 PITA;mirMAP;miRNATAP -0.165403673620787 0.00202940790109251 NA NA NA hsa-miR-141-5p PRKCB -0.354590233549885 0.867642456336402 -0.289166762598654 0.629896233011357 mirMAP -0.566149586465332 2.81537724392599e-08 NA NA NA hsa-miR-148a-5p PRKCB -0.448099743845604 0.748419139652266 -0.289166762598654 0.629896233011357 mirMAP -0.431607663118204 0.00014113366592115 NA NA NA hsa-miR-16-2-3p PRKCB -0.36717860153421 0.546850726070016 -0.289166762598654 0.629896233011357 mirMAP -0.556524355024035 7.09185137143842e-08 NA NA NA hsa-miR-186-5p PRKCB -0.318786974828757 0.85412722938961 -0.289166762598654 0.629896233011357 mirMAP -0.693684359345577 1.42561623028323e-05 NA NA NA hsa-miR-194-5p PRKCB -0.159001168846464 0.959682382557336 -0.289166762598654 0.629896233011357 miRNATAP -0.642313551381144 2.93325886945843e-10 NA NA NA hsa-miR-200b-3p PRKCB -0.426401948379212 0.863957108574195 -0.289166762598654 0.629896233011357 MirTarget -0.72108199701521 2.3659342346039e-11 NA NA NA hsa-miR-200c-3p PRKCB -0.437282635857873 0.887118598436407 -0.289166762598654 0.629896233011357 MirTarget;miRNATAP -0.752138899288806 1.18209268005294e-11 NA NA NA hsa-miR-23a-3p PRKCB -0.122198715333656 0.962717452143511 -0.289166762598654 0.629896233011357 mirMAP -0.972693790442231 3.83115244358293e-06 NA NA NA hsa-miR-24-3p PRKCB -0.0484778924256624 0.985274054814493 -0.289166762598654 0.629896233011357 miRNATAP -1.14917640884554 4.29809672564759e-07 NA NA NA hsa-miR-26b-5p PRKCB -0.0245931278499594 0.990377966314923 -0.289166762598654 0.629896233011357 mirMAP -0.759590158099125 4.96577614466636e-07 NA NA NA hsa-miR-27a-3p PRKCB -0.123902317731458 0.958804393510999 -0.289166762598654 0.629896233011357 MirTarget;miRNATAP -0.984191959979311 4.52942226692975e-08 NA NA NA hsa-miR-29a-5p PRKCB -0.31835175571979 0.600442757817281 -0.289166762598654 0.629896233011357 mirMAP -0.696324093556409 4.49269492269061e-12 NA NA NA hsa-miR-29b-1-5p PRKCB -0.642348119412534 0.293891497238796 -0.289166762598654 0.629896233011357 mirMAP -0.462740943974498 6.40796306307966e-09 NA NA NA hsa-miR-30b-5p PRKCB -0.0121430518253582 0.994622896704513 -0.289166762598654 0.629896233011357 mirMAP -0.662037641995433 1.55759802125021e-09 NA NA NA hsa-miR-30c-5p PRKCB -0.298383882401475 0.865809030482001 -0.289166762598654 0.629896233011357 mirMAP -0.651180444056476 5.12606576516922e-05 NA NA NA hsa-miR-30d-3p PRKCB -0.123474741320298 0.814905367625791 -0.289166762598654 0.629896233011357 mirMAP -0.66303716180293 1.26976276659109e-07 NA NA NA hsa-miR-30d-5p PRKCB -0.168211838771867 0.95173197030375 -0.289166762598654 0.629896233011357 mirMAP -0.584797855466169 5.33137646933608e-05 NA NA NA hsa-miR-335-3p PRKCB -0.244830745789445 0.88450019116631 -0.289166762598654 0.629896233011357 mirMAP -0.677283755988629 1.84838818790619e-11 NA NA NA hsa-miR-335-5p PRKCB -0.0284895175847679 0.973380867832231 -0.289166762598654 0.629896233011357 mirMAP -0.675730225781425 2.5572319841088e-11 NA NA NA hsa-miR-361-5p PRKCB -0.138735309928775 0.941495130308343 -0.289166762598654 0.629896233011357 MirTarget;miRanda;miRNATAP -0.865758986282353 6.88790498193778e-06 NA NA NA hsa-miR-429 PRKCB -0.456485631615963 0.806240953400535 -0.289166762598654 0.629896233011357 MirTarget;miRanda;miRNATAP -0.619682801567495 9.47055177854519e-13 NA NA NA hsa-miR-450b-5p PRKCB -0.0136687538973108 0.983149761399849 -0.289166762598654 0.629896233011357 miRNATAP -0.47287159382327 7.10615810748377e-05 NA NA NA hsa-miR-452-3p PRKCB -0.167134177977311 0.799008246175244 -0.289166762598654 0.629896233011357 mirMAP -0.513101429149364 6.7170941174423e-11 NA NA NA hsa-miR-484 PRKCB -0.179977202691249 0.886333755572375 -0.289166762598654 0.629896233011357 MirTarget;miRNATAP -0.612122177986842 1.70623299361676e-05 NA NA NA hsa-miR-491-5p PRKCB -0.585652105321328 0.0452620602586908 -0.289166762598654 0.629896233011357 miRanda -0.35090662989035 0.000620664439809745 NA NA NA hsa-miR-502-5p PRKCB -0.708507838520586 0.0261309781860104 -0.289166762598654 0.629896233011357 mirMAP -0.435593863435658 2.75280823982211e-06 NA NA NA hsa-miR-539-5p PRKCB 0.124342970087029 0.801067485473643 -0.289166762598654 0.629896233011357 mirMAP -0.432505044940763 0.00059746887984469 NA NA NA hsa-miR-589-3p PRKCB -0.835836305204965 0.0112001563801511 -0.289166762598654 0.629896233011357 mirMAP -0.335038959210738 0.00016508749914759 NA NA NA hsa-miR-589-5p PRKCB -0.448771545046784 0.722725226273464 -0.289166762598654 0.629896233011357 mirMAP -0.565653175638186 0.000328937511746594 NA NA NA hsa-miR-590-3p PRKCB -0.279244755376859 0.59126669933662 -0.289166762598654 0.629896233011357 mirMAP -0.422590592433378 8.43504361358025e-06 NA NA NA hsa-miR-590-5p PRKCB -0.547819833829572 0.472735645776647 -0.289166762598654 0.629896233011357 miRanda -0.600413375866668 1.04790649499024e-09 NA NA NA hsa-miR-7-1-3p PRKCB -0.462485777435991 0.665899751398166 -0.289166762598654 0.629896233011357 mirMAP -0.417430474142834 0.000191851900734184 NA NA NA hsa-miR-7-5p PRKCB 0.209645143210379 0.773705612298441 -0.289166762598654 0.629896233011357 MirTarget;miRNATAP -0.205730135642304 0.0042868075722764 NA NA NA hsa-miR-34c-5p PTPN11 -0.018707656771723 0.952788306178575 -0.147331564107356 0.929664645919991 miRanda -0.102977856144078 0.000100612447365417 NA NA NA hsa-miR-30c-2-3p RAC3 0.242912714924037 0.746927269997556 -0.189305936526801 0.723079466838889 miRNAWalker2_validate -0.284587404659289 0.00785701503311612 NA NA NA hsa-miR-130a-3p RALBP1 0.0910074087716906 0.929098200371948 -0.157450243407515 0.914260206930769 MirTarget;miRNATAP -0.120679706895492 0.00180018128466652 NA NA NA hsa-miR-217 RALBP1 0.341080669095094 0.760998144794468 -0.157450243407515 0.914260206930769 PITA;miRanda -0.125177325247734 5.91092345448423e-06 NA NA NA hsa-miR-493-3p RALBP1 0.187155206150961 0.763804147995973 -0.157450243407515 0.914260206930769 MirTarget -0.122876062507933 0.00352132590048744 NA NA NA hsa-miR-542-3p RALBP1 0.188168046511374 0.909252939431573 -0.157450243407515 0.914260206930769 miRanda -0.140155114295571 0.00205891526245392 NA NA NA hsa-miR-552-3p RALBP1 0.172135417326455 0.893972136172394 -0.157450243407515 0.914260206930769 MirTarget -0.10404482757975 1.4510812336363e-09 NA NA NA hsa-miR-19a-3p RAP1A -0.206793507801887 0.844637784802316 -0.110082502104731 0.934663978893337 MirTarget;miRNATAP -0.108944788434501 2.44713073021362e-06 NA NA NA hsa-miR-19b-3p RAP1A -0.0268530183621474 0.986656783046572 -0.110082502104731 0.934663978893337 MirTarget;miRNATAP -0.118776007635545 1.89944829990528e-05 NA NA NA hsa-miR-29a-5p RAP1A -0.31835175571979 0.600442757817281 -0.110082502104731 0.934663978893337 mirMAP -0.123144828542886 1.16978124618324e-06 NA NA NA hsa-miR-335-3p RAP1A -0.244830745789445 0.88450019116631 -0.110082502104731 0.934663978893337 mirMAP -0.119739493643969 2.31313425877955e-06 NA NA NA hsa-miR-539-5p RAP1A 0.124342970087029 0.801067485473643 -0.110082502104731 0.934663978893337 MirTarget;miRNATAP -0.123937631269248 5.48295403806522e-05 NA NA NA hsa-miR-92a-3p RAP1A 0.0278830870766349 0.993247426671713 -0.110082502104731 0.934663978893337 mirMAP;miRNATAP -0.156492439703989 3.32395854079154e-08 NA NA NA hsa-miR-101-3p RAP1B 0.0107754887734437 0.997036362636866 -0.0355605069345772 0.981492846834325 MirTarget;miRNATAP -0.221507424438491 1.25793937717131e-07 24697700 Functional analysis of miR 101 3p and Rap1b involved in hepatitis B virus related hepatocellular carcinoma pathogenesis; In this study we reported that HBV could repress miR-101-3p by inhibiting its promoter activity and identified the potential effects of miR-101-3p on some important biological properties of HCC cells by targeting Rap1b; Down-regulation of miR-101-3p promoted cell proliferation migration and reduced apoptosis and resulted in up-regulation of Rap1b while overexpression of miR-101-3p inhibited these processes; Moreover overexpression of Rap1b was able to reverse the suppressed cell proliferation and migration mediated by miR-101-3p; Our data showed that HBV down-regulated miR-101-3p expression by inhibiting its promoter activity which resulted in up-regulation of Rap1b and down-regulation of miR-101-3p or up-regulation of Rap1b promoted proliferation and migration of HCC cells liver cancer hsa-miR-101-5p RAP1B -0.27876696778882 0.558836382493107 -0.0355605069345772 0.981492846834325 MirTarget -0.132956879457368 1.70998872451677e-08 24697700 Functional analysis of miR 101 3p and Rap1b involved in hepatitis B virus related hepatocellular carcinoma pathogenesis liver cancer hsa-miR-181c-5p RAP1B 0.042951891660695 0.969159991881861 -0.0355605069345772 0.981492846834325 MirTarget;miRNATAP -0.113766940008307 0.000131137555874288 NA NA NA hsa-miR-19b-3p RAP1B -0.0268530183621474 0.986656783046572 -0.0355605069345772 0.981492846834325 MirTarget;miRNATAP -0.10301097686365 0.000278405572045985 NA NA NA hsa-miR-30e-5p RAP1B -0.0657075181381011 0.979684509181941 -0.0355605069345772 0.981492846834325 MirTarget -0.150708093051106 0.000701546039856641 NA NA NA hsa-miR-590-3p RASA1 -0.279244755376859 0.59126669933662 0.215021777812651 0.867101665724599 miRanda -0.100209393151771 0.0016091969209744 NA NA NA hsa-miR-126-5p RASA2 0.0815213541035824 0.956637332055185 0.165463563857519 0.789603043878574 mirMAP -0.227482475101361 4.08857147389352e-05 NA NA NA hsa-miR-30b-5p RASA2 -0.0121430518253582 0.994622896704513 0.165463563857519 0.789603043878574 mirMAP -0.173633552700649 4.14391515700245e-05 NA NA NA hsa-miR-30c-5p RASA2 -0.298383882401475 0.865809030482001 0.165463563857519 0.789603043878574 mirMAP -0.174257070580333 0.00450024995864311 NA NA NA hsa-miR-374b-5p RASA2 -0.285682091626878 0.83569830479965 0.165463563857519 0.789603043878574 mirMAP -0.194793699666533 0.00122135462011673 NA NA NA hsa-miR-590-3p RASA2 -0.279244755376859 0.59126669933662 0.165463563857519 0.789603043878574 mirMAP -0.124980383206198 0.000551181349839643 NA NA NA hsa-miR-186-5p RASA3 -0.318786974828757 0.85412722938961 0.0549766054240335 0.959978847220599 miRNATAP -0.317229633348135 0.00242290745693607 NA NA NA hsa-miR-335-5p RASA3 -0.0284895175847679 0.973380867832231 0.0549766054240335 0.959978847220599 miRNAWalker2_validate -0.297451451723274 1.02948704630384e-05 NA NA NA hsa-miR-421 RASA3 -0.182032017078616 0.734704500318599 0.0549766054240335 0.959978847220599 miRanda -0.355746156357993 3.71643205022773e-07 NA NA NA hsa-miR-590-3p RASA3 -0.279244755376859 0.59126669933662 0.0549766054240335 0.959978847220599 miRanda -0.228860126867349 0.000215147259812393 NA NA NA hsa-miR-92a-3p RASA3 0.0278830870766349 0.993247426671713 0.0549766054240335 0.959978847220599 miRNAWalker2_validate -0.282202344772181 0.000215030210000532 NA NA NA hsa-miR-1262 RASA4 -0.110067426706709 0.702946442225154 0.0845962292237177 0.906419211382211 mirMAP -0.163525095221473 0.0069312372010234 NA NA NA hsa-miR-1304-5p RASA4 -0.497887681787993 0.163079003594721 0.0845962292237177 0.906419211382211 mirMAP -0.162994599839541 0.000538541219098428 NA NA NA hsa-miR-141-3p RASA4 -0.31994058840327 0.87774106909065 0.0845962292237177 0.906419211382211 mirMAP -0.277916730326145 1.8760006621615e-07 NA NA NA hsa-miR-15b-5p RASA4 -0.272614787130877 0.87096541832188 0.0845962292237177 0.906419211382211 mirMAP -0.223879891985532 0.00200785301490261 NA NA NA hsa-miR-16-5p RASA4 0.0135949734723564 0.994476223855607 0.0845962292237177 0.906419211382211 mirMAP -0.227765956783249 0.00161394789473901 NA NA NA hsa-miR-181b-5p RASA4 0.155313039554487 0.930176779696506 0.0845962292237177 0.906419211382211 MirTarget -0.239050097396729 0.00155381521092614 NA NA NA hsa-miR-186-5p RASA4 -0.318786974828757 0.85412722938961 0.0845962292237177 0.906419211382211 mirMAP -0.3587382140565 5.92943331751325e-05 NA NA NA hsa-miR-194-3p RASA4 -0.614465699221301 0.733214497063146 0.0845962292237177 0.906419211382211 mirMAP -0.245706032129892 2.4574151866152e-06 NA NA NA hsa-miR-19b-1-5p RASA4 -0.0105982583216702 0.988511655226679 0.0845962292237177 0.906419211382211 mirMAP -0.17090589375107 0.00389437149991991 NA NA NA hsa-miR-200a-3p RASA4 -0.367034437440907 0.851059894150266 0.0845962292237177 0.906419211382211 mirMAP -0.223050540267088 2.12392154063291e-05 NA NA NA hsa-miR-452-3p RASA4 -0.167134177977311 0.799008246175244 0.0845962292237177 0.906419211382211 MirTarget -0.146383598380611 0.0012675481120035 NA NA NA hsa-miR-502-5p RASA4 -0.708507838520586 0.0261309781860104 0.0845962292237177 0.906419211382211 mirMAP -0.199362290434266 0.000133985575220341 NA NA NA hsa-miR-590-3p RASA4 -0.279244755376859 0.59126669933662 0.0845962292237177 0.906419211382211 miRanda;mirMAP -0.164918398415135 0.0020483670651382 NA NA NA hsa-miR-940 RASA4 -0.225788347550697 0.680055767105815 0.0845962292237177 0.906419211382211 mirMAP -0.12830968053225 0.00522006907861378 NA NA NA hsa-miR-98-5p RASAL2 -0.168162186023221 0.898802461503524 0.042066524811319 0.971287920543398 miRNAWalker2_validate -0.157131812253911 0.00379489223195944 NA NA NA hsa-let-7a-3p RASGRF2 -0.215598045625677 0.85543299203799 0.311212456313648 0.572114180174089 mirMAP -0.28208123010843 0.00318414737558839 NA NA NA hsa-miR-106a-5p RASGRF2 -0.203919267842652 0.802213958426804 0.311212456313648 0.572114180174089 MirTarget -0.319451020244955 0.000175380922127387 NA NA NA hsa-miR-106b-5p RASGRF2 -0.297128724729339 0.869294443540749 0.311212456313648 0.572114180174089 MirTarget -0.470801946449999 1.40014164959058e-06 NA NA NA hsa-miR-17-5p RASGRF2 -0.175448849583061 0.934544015912731 0.311212456313648 0.572114180174089 MirTarget;TargetScan -0.31257473210719 2.95587250698283e-05 NA NA NA hsa-miR-20a-5p RASGRF2 -0.179153323927949 0.928118119139752 0.311212456313648 0.572114180174089 MirTarget -0.257760692785249 0.000511086767535332 NA NA NA hsa-miR-30d-3p RASGRF2 -0.123474741320298 0.814905367625791 0.311212456313648 0.572114180174089 mirMAP -0.381418983283036 6.4191136467502e-05 NA NA NA hsa-miR-421 RASGRF2 -0.182032017078616 0.734704500318599 0.311212456313648 0.572114180174089 miRanda;mirMAP -0.235273941574404 0.00447281020108419 NA NA NA hsa-miR-429 RASGRF2 -0.456485631615963 0.806240953400535 0.311212456313648 0.572114180174089 miRanda -0.278228357074767 3.91157033483491e-05 NA NA NA hsa-miR-548o-3p RASGRF2 -0.191447572716994 0.517725546183501 0.311212456313648 0.572114180174089 mirMAP -0.272795500205695 0.000518960379802912 NA NA NA hsa-miR-590-3p RASGRF2 -0.279244755376859 0.59126669933662 0.311212456313648 0.572114180174089 MirTarget;miRanda -0.192732544282602 0.00761336990272499 NA NA NA hsa-miR-590-5p RASGRF2 -0.547819833829572 0.472735645776647 0.311212456313648 0.572114180174089 miRanda -0.258672488025639 0.000662870014943329 NA NA NA hsa-miR-93-5p RASGRF2 -0.611073677204699 0.825297877093193 0.311212456313648 0.572114180174089 MirTarget -0.27164204411933 0.00377079585422263 NA NA NA hsa-miR-135b-3p RASGRP1 0.0147512394776733 0.969435415142768 -0.880190878481172 0.0505475345286302 MirTarget -0.235695387126061 0.000223917471151014 NA NA NA hsa-miR-17-3p RASGRP1 0.100221625453134 0.960113387014848 -0.880190878481172 0.0505475345286302 MirTarget -0.280140752107922 0.00302143560347656 NA NA NA hsa-miR-196a-5p RASGRP1 -0.0569856738232488 0.973093117800687 -0.880190878481172 0.0505475345286302 MirTarget;miRNATAP -0.168935124065029 0.00210109998518396 NA NA NA hsa-miR-196b-5p RASGRP1 -0.0840912027031901 0.972112413910242 -0.880190878481172 0.0505475345286302 MirTarget;miRNATAP -0.231438319843541 1.22787828672472e-05 NA NA NA hsa-miR-335-5p RASGRP1 -0.0284895175847679 0.973380867832231 -0.880190878481172 0.0505475345286302 miRNAWalker2_validate -0.46272725902458 2.17122351953388e-08 NA NA NA hsa-miR-429 RASGRP1 -0.456485631615963 0.806240953400535 -0.880190878481172 0.0505475345286302 miRanda -0.266958219546344 0.000245088973922056 NA NA NA hsa-miR-452-5p RASGRP1 -0.0504626418153507 0.973874641360401 -0.880190878481172 0.0505475345286302 MirTarget -0.259451519342612 0.00359364374682818 NA NA NA hsa-miR-590-5p RASGRP1 -0.547819833829572 0.472735645776647 -0.880190878481172 0.0505475345286302 MirTarget;PITA;miRanda;miRNATAP -0.239344851743249 0.00339966068600183 NA NA NA hsa-miR-98-5p RASGRP1 -0.168162186023221 0.898802461503524 -0.880190878481172 0.0505475345286302 MirTarget -0.393283603173063 0.00171055465985574 NA NA NA hsa-miR-324-3p RASGRP2 -0.424387380347173 0.661528309116338 -0.139328052626859 0.745732729821851 PITA -0.416147559442335 0.00107032225354736 NA NA NA hsa-miR-484 RASGRP2 -0.179977202691249 0.886333755572375 -0.139328052626859 0.745732729821851 PITA -0.452835619989423 0.000500703074371668 NA NA NA hsa-miR-940 RASGRP2 -0.225788347550697 0.680055767105815 -0.139328052626859 0.745732729821851 MirTarget;PITA;miRNATAP -0.250739632540125 0.000765703616105639 NA NA NA hsa-miR-320a RASGRP3 -0.416546433767628 0.840202138616422 0.150983045514593 0.817693561351607 miRanda -0.250683668001994 0.00176057255260304 NA NA NA hsa-miR-324-3p RASGRP3 -0.424387380347173 0.661528309116338 0.150983045514593 0.817693561351607 MirTarget -0.221435212427347 0.00713652020206053 NA NA NA hsa-miR-339-5p RASGRP3 -0.300425087100667 0.712912847076788 0.150983045514593 0.817693561351607 miRanda -0.330175542150378 6.13678552903612e-10 NA NA NA hsa-miR-362-3p RASGRP3 -0.721040238345347 0.0345881362485733 0.150983045514593 0.817693561351607 miRanda -0.21281358143254 9.03646264528514e-05 NA NA NA hsa-miR-590-5p RASGRP3 -0.547819833829572 0.472735645776647 0.150983045514593 0.817693561351607 miRanda -0.333701005351422 7.75357318321857e-09 NA NA NA hsa-miR-7-1-3p RASGRP3 -0.462485777435991 0.665899751398166 0.150983045514593 0.817693561351607 mirMAP -0.248174780369912 0.000148598901996924 NA NA NA hsa-miR-1275 RASGRP4 -0.831342050607648 0.0803795852164229 -0.19645646116476 0.636382399011337 MirTarget -0.290074813600451 5.487239434527e-06 NA NA NA hsa-miR-135b-3p RASGRP4 0.0147512394776733 0.969435415142768 -0.19645646116476 0.636382399011337 MirTarget -0.192831186048658 0.00690426081434629 NA NA NA hsa-miR-30b-3p RASGRP4 -0.514644352757504 0.162424853398397 -0.19645646116476 0.636382399011337 MirTarget -0.417705543365615 2.31278949257711e-05 NA NA NA hsa-miR-34a-5p RASGRP4 -0.50188164870224 0.742034237185732 -0.19645646116476 0.636382399011337 MirTarget -0.299229491587927 0.00652353901993204 NA NA NA hsa-miR-577 RASGRP4 -1.06238199218774 0.326056761787754 -0.19645646116476 0.636382399011337 miRNATAP -0.237381595432657 6.66093594627961e-06 NA NA NA hsa-miR-625-5p RASGRP4 -0.690759472145277 0.210306534567564 -0.19645646116476 0.636382399011337 MirTarget -0.248407251271582 0.000957235219227392 NA NA NA hsa-miR-335-5p RASSF5 -0.0284895175847679 0.973380867832231 0.11677158378139 0.894550636105211 miRNAWalker2_validate -0.468574924759487 1.88727172182423e-11 NA NA NA hsa-miR-339-5p RASSF5 -0.300425087100667 0.712912847076788 0.11677158378139 0.894550636105211 miRanda -0.451575445875511 2.89329933109232e-13 NA NA NA hsa-miR-374b-5p RASSF5 -0.285682091626878 0.83569830479965 0.11677158378139 0.894550636105211 miRNAWalker2_validate -0.550367857836858 3.43584200141552e-07 NA NA NA hsa-miR-421 RASSF5 -0.182032017078616 0.734704500318599 0.11677158378139 0.894550636105211 miRanda -0.352767318203555 2.42791174101651e-06 NA NA NA hsa-miR-532-5p RASSF5 -0.349665553500088 0.878948352437467 0.11677158378139 0.894550636105211 PITA;miRNATAP -0.325280594393783 3.42989196774391e-05 NA NA NA hsa-miR-576-5p RASSF5 -0.506413219377403 0.417187951364173 0.11677158378139 0.894550636105211 mirMAP -0.25546080844315 0.00128346501452201 NA NA NA hsa-miR-98-5p REL -0.168162186023221 0.898802461503524 -0.217057304167286 0.612576702688344 miRNAWalker2_validate -0.222680609212712 0.0049204695880801 NA NA NA hsa-miR-106a-5p RGL1 -0.203919267842652 0.802213958426804 0.251168463967325 0.766051652637177 MirTarget;miRNATAP -0.270895512521887 2.4486861767314e-05 NA NA NA hsa-miR-106b-5p RGL1 -0.297128724729339 0.869294443540749 0.251168463967325 0.766051652637177 MirTarget;miRNATAP -0.572149234279168 4.78705542834861e-16 NA NA NA hsa-miR-130b-5p RGL1 -0.6472141103776 0.379096015222509 0.251168463967325 0.766051652637177 mirMAP -0.432341286082665 8.45812317405053e-13 NA NA NA hsa-miR-135b-5p RGL1 0.631573976263484 0.610028066417462 0.251168463967325 0.766051652637177 MirTarget -0.169696230331121 1.71292211217709e-05 NA NA NA hsa-miR-144-3p RGL1 0.0482420655617901 0.935871997593533 0.251168463967325 0.766051652637177 miRNATAP -0.139126227504047 0.000448036012378689 NA NA NA hsa-miR-16-2-3p RGL1 -0.36717860153421 0.546850726070016 0.251168463967325 0.766051652637177 mirMAP -0.37043822602304 1.57568509656703e-10 NA NA NA hsa-miR-17-5p RGL1 -0.175448849583061 0.934544015912731 0.251168463967325 0.766051652637177 MirTarget;TargetScan;miRNATAP -0.346829642768898 3.56035558906788e-10 NA NA NA hsa-miR-182-5p RGL1 -0.104238497940557 0.973380614062243 0.251168463967325 0.766051652637177 MirTarget -0.242983189203375 2.03865395257177e-05 NA NA NA hsa-miR-19a-3p RGL1 -0.206793507801887 0.844637784802316 0.251168463967325 0.766051652637177 MirTarget;miRNATAP -0.340303022374852 8.3982096175434e-11 NA NA NA hsa-miR-19b-3p RGL1 -0.0268530183621474 0.986656783046572 0.251168463967325 0.766051652637177 MirTarget;miRNATAP -0.330386890684119 2.20440715066479e-07 NA NA NA hsa-miR-200b-3p RGL1 -0.426401948379212 0.863957108574195 0.251168463967325 0.766051652637177 MirTarget;TargetScan -0.377148621986071 1.05615856125396e-09 NA NA NA hsa-miR-200c-3p RGL1 -0.437282635857873 0.887118598436407 0.251168463967325 0.766051652637177 MirTarget;miRNATAP -0.394483329236215 5.29907025445824e-10 NA NA NA hsa-miR-20a-5p RGL1 -0.179153323927949 0.928118119139752 0.251168463967325 0.766051652637177 MirTarget;miRNATAP -0.297018966320088 7.05322733510452e-08 NA NA NA hsa-miR-25-3p RGL1 -0.457540448732733 0.878574066837636 0.251168463967325 0.766051652637177 MirTarget -0.472914250383794 1.52436894658013e-07 NA NA NA hsa-miR-30c-5p RGL1 -0.298383882401475 0.865809030482001 0.251168463967325 0.766051652637177 miRNATAP -0.366449254987803 6.07202062724997e-05 NA NA NA hsa-miR-32-5p RGL1 -0.05993267619119 0.952975951594959 0.251168463967325 0.766051652637177 MirTarget -0.365307708883852 4.01109127473288e-09 NA NA NA hsa-miR-335-3p RGL1 -0.244830745789445 0.88450019116631 0.251168463967325 0.766051652637177 mirMAP -0.274009053018673 3.15642764320002e-06 NA NA NA hsa-miR-339-5p RGL1 -0.300425087100667 0.712912847076788 0.251168463967325 0.766051652637177 miRNATAP -0.277664053716924 1.18959457458219e-07 NA NA NA hsa-miR-429 RGL1 -0.456485631615963 0.806240953400535 0.251168463967325 0.766051652637177 MirTarget;PITA;miRanda;miRNATAP -0.345271081676075 2.87723443146594e-12 NA NA NA hsa-miR-501-5p RGL1 -0.834032628506285 0.0582725160418523 0.251168463967325 0.766051652637177 MirTarget;PITA;miRNATAP -0.139667202858257 0.00408115250545042 NA NA NA hsa-miR-582-3p RGL1 -0.2334649592375 0.897678119160318 0.251168463967325 0.766051652637177 PITA -0.316396778562385 2.68485718070275e-06 NA NA NA hsa-miR-625-5p RGL1 -0.690759472145277 0.210306534567564 0.251168463967325 0.766051652637177 MirTarget -0.343055594054709 4.68811784609817e-14 NA NA NA hsa-miR-642a-5p RGL1 0.00605485088835034 0.98806034007652 0.251168463967325 0.766051652637177 MirTarget -0.143843540899887 0.000813092475137492 NA NA NA hsa-miR-7-1-3p RGL1 -0.462485777435991 0.665899751398166 0.251168463967325 0.766051652637177 MirTarget;mirMAP -0.429229909642949 2.18046640175965e-12 NA NA NA hsa-miR-92a-3p RGL1 0.0278830870766349 0.993247426671713 0.251168463967325 0.766051652637177 MirTarget -0.261306046926255 9.18118380642405e-05 NA NA NA hsa-miR-92b-3p RGL1 -0.569866984318692 0.689321861489779 0.251168463967325 0.766051652637177 MirTarget -0.172362001519284 0.0061395867594887 NA NA NA hsa-miR-93-5p RGL1 -0.611073677204699 0.825297877093193 0.251168463967325 0.766051652637177 MirTarget;miRNATAP -0.444558596572529 7.864213437071e-11 NA NA NA hsa-miR-96-5p RGL1 0.0854810872029343 0.923087820185031 0.251168463967325 0.766051652637177 mirMAP -0.355640642991622 4.27736460658824e-11 NA NA NA hsa-miR-361-5p RHOA -0.138735309928775 0.941495130308343 -0.17248196974016 0.934600726677384 MirTarget;PITA;miRanda -0.125411234757926 0.000736149169851785 NA NA NA hsa-miR-1304-5p RRAS -0.497887681787993 0.163079003594721 0.304022511420579 0.817721463502104 MirTarget -0.121654938697186 0.000101970906172872 NA NA NA hsa-miR-1306-3p RRAS -0.685383378847264 0.0170881307035124 0.304022511420579 0.817721463502104 MirTarget -0.135128354086083 0.000394160107642822 NA NA NA hsa-miR-140-5p SHC4 -0.229213026275906 0.847330111738616 0.572959933143452 0.217991886412631 MirTarget;miRanda -0.443329081820788 0.00232536961803113 NA NA NA hsa-miR-151a-3p SHC4 -0.0829874640636401 0.975334671097605 0.572959933143452 0.217991886412631 MirTarget -0.842828312033518 1.91786596361732e-09 NA NA NA hsa-miR-16-1-3p SHC4 0.151694812889216 0.733736501874638 0.572959933143452 0.217991886412631 MirTarget -0.524241147198433 5.8929627564827e-10 NA NA NA hsa-miR-182-5p SHC4 -0.104238497940557 0.973380614062243 0.572959933143452 0.217991886412631 MirTarget;miRNATAP -0.324649121155477 0.000192144875837249 NA NA NA hsa-miR-186-5p SHC4 -0.318786974828757 0.85412722938961 0.572959933143452 0.217991886412631 MirTarget;mirMAP -1.0643635295531 4.30547321913455e-16 NA NA NA hsa-miR-20a-3p SHC4 0.456808229166028 0.57674056136504 0.572959933143452 0.217991886412631 miRNATAP -0.450168659396644 1.34729104409805e-11 NA NA NA hsa-miR-27a-3p SHC4 -0.123902317731458 0.958804393510999 0.572959933143452 0.217991886412631 MirTarget -0.762304507860446 1.09355408062983e-06 NA NA NA hsa-miR-324-3p SHC4 -0.424387380347173 0.661528309116338 0.572959933143452 0.217991886412631 PITA -0.639849247755692 6.67873361087905e-08 NA NA NA hsa-miR-335-3p SHC4 -0.244830745789445 0.88450019116631 0.572959933143452 0.217991886412631 mirMAP -0.537420495850582 9.13864902869372e-10 NA NA NA hsa-miR-335-5p SHC4 -0.0284895175847679 0.973380867832231 0.572959933143452 0.217991886412631 miRNAWalker2_validate -0.557991997406246 2.12143681107387e-10 NA NA NA hsa-miR-361-5p SHC4 -0.138735309928775 0.941495130308343 0.572959933143452 0.217991886412631 miRanda -0.967824694163204 3.17286384255953e-09 NA NA NA hsa-miR-429 SHC4 -0.456485631615963 0.806240953400535 0.572959933143452 0.217991886412631 miRanda -0.583214458353377 3.30385397253911e-15 NA NA NA hsa-miR-576-5p SHC4 -0.506413219377403 0.417187951364173 0.572959933143452 0.217991886412631 mirMAP -0.713612229003629 3.77553285668998e-14 NA NA NA hsa-miR-577 SHC4 -1.06238199218774 0.326056761787754 0.572959933143452 0.217991886412631 mirMAP -0.3361753703593 1.1462182760433e-11 NA NA NA hsa-miR-590-3p SHC4 -0.279244755376859 0.59126669933662 0.572959933143452 0.217991886412631 PITA;miRanda;mirMAP;miRNATAP -0.561313892448108 1.33532008248689e-12 NA NA NA hsa-miR-590-5p SHC4 -0.547819833829572 0.472735645776647 0.572959933143452 0.217991886412631 miRanda -0.650808702065256 3.40225493537294e-15 NA NA NA hsa-miR-96-5p SHC4 0.0854810872029343 0.923087820185031 0.572959933143452 0.217991886412631 TargetScan;miRNATAP -0.481892792250505 5.92582417387469e-09 NA NA NA hsa-miR-27a-3p SOS1 -0.123902317731458 0.958804393510999 -0.133663949462885 0.918709253182528 MirTarget;miRNATAP -0.128294784600539 0.000637917145382412 NA NA NA hsa-miR-369-3p SOS1 0.116576891957687 0.83230082995912 -0.133663949462885 0.918709253182528 miRNATAP -0.135959090885724 6.65395075102377e-09 NA NA NA hsa-miR-381-3p SOS1 0.0562600264188893 0.966895219811624 -0.133663949462885 0.918709253182528 MirTarget -0.100940916746464 0.00276528516676685 NA NA NA hsa-miR-130a-3p SOS2 0.0910074087716906 0.929098200371948 -0.0380982568268919 0.974772477648122 miRNATAP -0.106710417537474 0.00163707990890625 NA NA NA hsa-miR-146b-5p SOS2 -0.402662509440887 0.837510937985091 -0.0380982568268919 0.974772477648122 miRanda -0.166193413119417 6.48354241761314e-06 NA NA NA hsa-miR-154-5p SOS2 -0.058936877201993 0.864854818862396 -0.0380982568268919 0.974772477648122 miRNATAP -0.116649989146456 0.00011300613484555 NA NA NA hsa-miR-493-5p SOS2 0.229930075372342 0.731979520100109 -0.0380982568268919 0.974772477648122 miRNATAP -0.128957133953108 0.00138950642379943 NA NA NA hsa-miR-185-5p SYNGAP1 -0.294432218239008 0.820591478398594 0.152535393927518 0.861160047885841 mirMAP;miRNATAP -0.184274032679699 0.00090198240704397 NA NA NA hsa-miR-29a-3p SYNGAP1 0.01127474410284 0.996977020481272 0.152535393927518 0.861160047885841 miRNATAP -0.15344162131189 0.00314974830146479 NA NA NA hsa-miR-625-5p SYNGAP1 -0.690759472145277 0.210306534567564 0.152535393927518 0.861160047885841 mirMAP -0.125214582761005 1.28179584733374e-05 NA NA NA hsa-miR-671-5p SYNGAP1 -0.373754118103105 0.411207779636977 0.152535393927518 0.861160047885841 PITA;miRNATAP -0.160959592728473 7.60605007234539e-05 NA NA NA hsa-miR-126-3p TEK -0.106293136341574 0.963670566555251 -0.0316898392412814 0.959248838487476 miRNAWalker2_validate;miRTarBase -0.324851412197732 0.00279806594030343 NA NA NA hsa-miR-421 TEK -0.182032017078616 0.734704500318599 -0.0316898392412814 0.959248838487476 miRanda -0.384088160282768 2.49335939254388e-06 NA NA NA hsa-miR-491-3p TEK -0.513850326596847 0.137836285146052 -0.0316898392412814 0.959248838487476 PITA -0.352185084466575 7.51731532906315e-07 NA NA NA hsa-miR-106a-5p TIAM1 -0.203919267842652 0.802213958426804 -0.038432182411362 0.94117977431505 MirTarget;miRNATAP -0.479697921596162 5.06610419873462e-06 NA NA NA hsa-miR-106b-5p TIAM1 -0.297128724729339 0.869294443540749 -0.038432182411362 0.94117977431505 MirTarget;miRNATAP -0.613427925525506 4.0785172243965e-07 NA NA NA hsa-miR-135b-5p TIAM1 0.631573976263484 0.610028066417462 -0.038432182411362 0.94117977431505 MirTarget -0.273250622848775 2.5653537152459e-05 NA NA NA hsa-miR-141-3p TIAM1 -0.31994058840327 0.87774106909065 -0.038432182411362 0.94117977431505 MirTarget;TargetScan;miRNATAP -0.452816910463211 4.22819969997005e-07 NA NA NA hsa-miR-17-5p TIAM1 -0.175448849583061 0.934544015912731 -0.038432182411362 0.94117977431505 MirTarget;TargetScan;miRNATAP -0.512145423481147 2.33862794806885e-08 NA NA NA hsa-miR-188-5p TIAM1 -0.568517670542551 0.324820848307954 -0.038432182411362 0.94117977431505 MirTarget -0.417874415044463 7.37057618127816e-08 NA NA NA hsa-miR-200a-3p TIAM1 -0.367034437440907 0.851059894150266 -0.038432182411362 0.94117977431505 MirTarget;miRNATAP -0.359051269860523 4.54950342546528e-05 NA NA NA hsa-miR-20a-5p TIAM1 -0.179153323927949 0.928118119139752 -0.038432182411362 0.94117977431505 MirTarget;miRNATAP -0.470474336320677 2.19230898903405e-07 NA NA NA hsa-miR-221-3p TIAM1 0.0906940388127513 0.959121118272534 -0.038432182411362 0.94117977431505 miRNAWalker2_validate -0.530834867168603 5.39819485561621e-05 NA NA NA hsa-miR-29a-3p TIAM1 0.01127474410284 0.996977020481272 -0.038432182411362 0.94117977431505 miRNATAP -0.66269507303917 1.85815698657596e-06 NA NA NA hsa-miR-29a-5p TIAM1 -0.31835175571979 0.600442757817281 -0.038432182411362 0.94117977431505 MirTarget -0.380816435658577 9.27346384561447e-05 NA NA NA hsa-miR-29b-3p TIAM1 -0.104016192263954 0.958988036765397 -0.038432182411362 0.94117977431505 miRNATAP -0.45456842889427 1.72207302318587e-05 25032858 miR 29b suppresses tumor growth and metastasis in colorectal cancer via downregulating Tiam1 expression and inhibiting epithelial mesenchymal transition; Further studies found that T lymphoma invasion and metastasis 1 Tiam1 was identified as a direct target of miR-29b metastasis colorectal cancer hsa-miR-335-3p TIAM1 -0.244830745789445 0.88450019116631 -0.038432182411362 0.94117977431505 MirTarget -0.582446990426745 8.44074663312608e-10 NA NA NA hsa-miR-335-5p TIAM1 -0.0284895175847679 0.973380867832231 -0.038432182411362 0.94117977431505 miRNAWalker2_validate -0.688964169985098 1.80754744457016e-13 NA NA NA hsa-miR-361-5p TIAM1 -0.138735309928775 0.941495130308343 -0.038432182411362 0.94117977431505 miRanda -0.742825955506893 3.82942528001718e-05 NA NA NA hsa-miR-362-3p TIAM1 -0.721040238345347 0.0345881362485733 -0.038432182411362 0.94117977431505 miRanda -0.324335989529112 0.00019024934838185 NA NA NA hsa-miR-376a-5p TIAM1 0.0978680856849549 0.773217338913054 -0.038432182411362 0.94117977431505 MirTarget -0.33909075629673 0.000283665833851744 NA NA NA hsa-miR-376b-3p TIAM1 -0.00712550627858333 0.982426403308526 -0.038432182411362 0.94117977431505 MirTarget -0.263305280310585 0.00463345376943316 NA NA NA hsa-miR-590-3p TIAM1 -0.279244755376859 0.59126669933662 -0.038432182411362 0.94117977431505 miRanda;mirMAP -0.374136529158175 2.51491052655511e-05 NA NA NA hsa-miR-590-5p TIAM1 -0.547819833829572 0.472735645776647 -0.038432182411362 0.94117977431505 MirTarget;PITA;miRanda;miRNATAP -0.480192910314154 2.39490130165144e-07 NA NA NA hsa-miR-592 TIAM1 -0.177670083168544 0.856226890424691 -0.038432182411362 0.94117977431505 PITA -0.21553241181099 1.26503670938925e-06 NA NA NA hsa-miR-93-3p TIAM1 -0.438355548962673 0.549902689385444 -0.038432182411362 0.94117977431505 miRNAWalker2_validate -0.407406716017756 8.0205462626313e-05 NA NA NA hsa-miR-93-5p TIAM1 -0.611073677204699 0.825297877093193 -0.038432182411362 0.94117977431505 MirTarget;miRNATAP -0.430652802995566 0.0002048672645737 NA NA NA hsa-miR-96-5p TIAM1 0.0854810872029343 0.923087820185031 -0.038432182411362 0.94117977431505 TargetScan -0.399075417047418 1.17545558043591e-05 NA NA NA hsa-miR-1-3p VEGFA 0.743297777604706 0.502740755603748 0.44291481761107 0.794175304752332 MirTarget -0.116378239250321 6.72225230732928e-05 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-129-5p VEGFA 0.268577986151378 0.553351908525147 0.44291481761107 0.794175304752332 miRanda -0.105916187808699 0.00205982654647779 NA NA NA hsa-miR-150-5p VEGFA -0.380115629777847 0.838788934042507 0.44291481761107 0.794175304752332 miRNAWalker2_validate;miRTarBase -0.105332454174453 0.00212185781504366 NA NA NA hsa-miR-195-5p VEGFA 0.343201952346823 0.749622318650888 0.44291481761107 0.794175304752332 miRNAWalker2_validate;miRTarBase;MirTarget -0.17069720152047 0.00113687245030063 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-342-3p VEGFA -0.371626144515113 0.77313668985267 0.44291481761107 0.794175304752332 miRanda;miRNATAP -0.180071200249696 0.000461735316514135 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-642a-5p VEGFB 0.00605485088835034 0.98806034007652 0.186752095884063 0.879413489616489 MirTarget -0.110252259736901 4.41057201692337e-05 NA NA NA hsa-miR-128-3p VEGFC -0.442192625156042 0.783886533572187 0.47579727228228 0.306081464218048 miRNAWalker2_validate;MirTarget -0.703841140515502 1.79431671849186e-11 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-16-2-3p VEGFC -0.36717860153421 0.546850726070016 0.47579727228228 0.306081464218048 MirTarget -0.577975043513837 2.82952367749584e-15 NA NA NA hsa-miR-27a-3p VEGFC -0.123902317731458 0.958804393510999 0.47579727228228 0.306081464218048 MirTarget -0.506585140692086 0.000168779320063404 NA NA NA hsa-miR-374a-5p VEGFC -0.343007247142618 0.766921280269271 0.47579727228228 0.306081464218048 MirTarget -0.563100644665433 2.34179983517396e-06 NA NA NA hsa-miR-374b-5p VEGFC -0.285682091626878 0.83569830479965 0.47579727228228 0.306081464218048 MirTarget -0.605816787637354 1.34969594387806e-07 NA NA NA hsa-miR-590-3p VEGFC -0.279244755376859 0.59126669933662 0.47579727228228 0.306081464218048 miRanda -0.48851698816486 3.73378001214407e-13 NA NA NA hsa-miR-339-5p ZAP70 -0.300425087100667 0.712912847076788 -0.226587123533471 0.660766737901749 miRanda -0.277630785191796 0.00108556595543045 NA NA NA