miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-3p ABI3BP 0.82512001802525 0.0468122405194487 -5.0431660630446 2.33019389310367e-05 miRNATAP -0.548780739042994 0.000976066059488311 NA NA NA hsa-miR-107 ABI3BP 1.49443409571439 0.000130594521065411 -5.0431660630446 2.33019389310367e-05 miRanda -0.52438078497958 0.00288329219152736 NA NA NA hsa-miR-32-3p ABI3BP 2.20477794939766 0.0392771274032852 -5.0431660630446 2.33019389310367e-05 mirMAP -0.438051580861093 9.36227543353754e-05 NA NA NA hsa-miR-421 ABI3BP 1.97624148591545 0.000915838012451138 -5.0431660630446 2.33019389310367e-05 miRanda -0.382037940945312 0.000844226576452226 NA NA NA hsa-miR-576-5p ABI3BP 1.30320223793746 0.00648929463912994 -5.0431660630446 2.33019389310367e-05 PITA -0.557837408253045 9.24992541169262e-05 NA NA NA hsa-miR-590-5p ABI3BP 1.51400888103768 0.0023888567923017 -5.0431660630446 2.33019389310367e-05 miRanda -0.602776878498076 9.63318752271296e-06 NA NA NA hsa-miR-92a-3p ABI3BP 1.87892405805529 1.27013821556583e-05 -5.0431660630446 2.33019389310367e-05 miRNATAP -1.01864794369404 3.91871851928313e-11 NA NA NA hsa-miR-92b-3p ABI3BP 1.69303761469782 0.0103484911955574 -5.0431660630446 2.33019389310367e-05 miRNATAP -0.361091202141468 0.000460998828690392 NA NA NA hsa-miR-484 ACTA2 1.79050445056016 0.000217287101253701 -6.6619562090709 1.61882410929165e-14 miRNAWalker2_validate -0.494471644745982 2.43231367441334e-06 NA NA NA hsa-miR-20b-5p ADAM12 4.5662923200279 4.75238200639144e-05 2.46383179075414 0.0148984276199091 mirMAP -0.191379990250172 0.000139222699538766 NA NA NA hsa-miR-26a-5p ADAM12 -0.352368463397074 0.362040749917446 2.46383179075414 0.0148984276199091 mirMAP;miRNATAP -0.41839849438381 0.00572589977192185 NA NA NA hsa-miR-3065-5p ADAM12 2.14185373842821 0.0609400502269891 2.46383179075414 0.0148984276199091 mirMAP -0.174905045812979 0.00519929463060813 NA NA NA hsa-miR-3607-3p ADAM12 1.38015131722213 0.0240067155694847 2.46383179075414 0.0148984276199091 mirMAP;miRNATAP -0.244877226708002 0.00935487081453369 NA NA NA hsa-miR-429 ADAM12 6.39965293994036 1.96920201593608e-18 2.46383179075414 0.0148984276199091 miRanda;miRNATAP -0.197294977779962 0.00792694014452854 NA NA NA hsa-miR-24-3p ANPEP 1.55853749533999 0.000524726461381821 1.709629567832 0.140652654875434 miRNAWalker2_validate -0.493509074275521 0.000741410526751225 NA NA NA hsa-miR-200b-3p BASP1 5.56167217794639 6.43540045061709e-16 -1.12470485256406 0.329085541806455 TargetScan -0.72674548391977 2.44718206752463e-17 NA NA NA hsa-miR-200c-3p BASP1 6.47012025883743 2.64500707716408e-26 -1.12470485256406 0.329085541806455 miRNATAP -0.291463690661245 0.00303872235672823 NA NA NA hsa-miR-429 BASP1 6.39965293994036 1.96920201593608e-18 -1.12470485256406 0.329085541806455 PITA;miRanda;miRNATAP -0.547598151591921 2.13268347915168e-11 NA NA NA hsa-miR-532-3p BASP1 0.643755490841218 0.214842585969913 -1.12470485256406 0.329085541806455 PITA -0.490626145023032 9.69984994464216e-05 NA NA NA hsa-miR-1-3p BDNF -3.85397883903804 6.93274972711165e-06 1.9301309436685 0.15402934773225 miRTarBase;MirTarget -0.238246139789509 0.00699566300603736 NA NA NA hsa-miR-146b-5p BDNF 1.87569569182453 0.000737241069698886 1.9301309436685 0.15402934773225 miRanda -0.397605085388184 0.00388699211645475 NA NA NA hsa-miR-330-5p BGN 2.25110496739954 0.000275527655397415 -1.58185047345876 0.0699270579439759 miRanda -0.245790666568634 0.00196053696300378 NA NA NA hsa-miR-34a-5p BMP1 0.830377770217786 0.0477544831885907 0.584130983449287 0.324075324220258 mirMAP -0.304526845215945 0.000150437690636125 NA NA NA hsa-miR-362-5p BMP1 -1.22309034685697 0.0452665543907975 0.584130983449287 0.324075324220258 mirMAP -0.293368416086505 5.4497803872177e-08 NA NA NA hsa-miR-429 BMP1 6.39965293994036 1.96920201593608e-18 0.584130983449287 0.324075324220258 miRNATAP -0.233910624782937 3.61180865367793e-08 NA NA NA hsa-miR-142-5p CADM1 3.95552531913424 1.49536283724079e-08 -1.82364278704712 0.103960712759009 PITA -0.236405279313642 0.00792631480906811 NA NA NA hsa-miR-152-3p CADM1 0.0996927696128376 0.867443498706607 -1.82364278704712 0.103960712759009 MirTarget -0.439690972707729 3.49282002815407e-05 NA NA NA hsa-miR-16-5p CADM1 2.93575808220754 2.15436817162977e-10 -1.82364278704712 0.103960712759009 miRNAWalker2_validate;miRTarBase;miRNATAP -0.396201218562889 0.00323262137974947 NA NA NA hsa-miR-193a-3p CADM1 0.646392169474854 0.207134343676122 -1.82364278704712 0.103960712759009 MirTarget;PITA;miRanda;miRNATAP -0.574250903197164 3.40814616143119e-06 NA NA NA hsa-miR-1976 CADM1 3.27217274919653 3.16337235854532e-12 -1.82364278704712 0.103960712759009 MirTarget -0.374424282760908 0.00444980170234356 NA NA NA hsa-miR-205-5p CADM1 8.08298115900323 3.83045179398654e-07 -1.82364278704712 0.103960712759009 MirTarget;miRNATAP -0.2704032353001 7.35977173175252e-13 NA NA NA hsa-miR-224-3p CADM1 2.84876340814503 0.000179138399939161 -1.82364278704712 0.103960712759009 MirTarget -0.41678333785007 4.1499357302005e-07 NA NA NA hsa-miR-23a-3p CADM1 0.925125296618358 0.0127293543936914 -1.82364278704712 0.103960712759009 miRNATAP -0.683135518165834 7.63116281898547e-05 NA NA NA hsa-miR-27a-3p CADM1 1.76094007417453 0.000216137556256765 -1.82364278704712 0.103960712759009 MirTarget;miRNATAP -0.7330274702913 2.20308827361021e-08 NA NA NA hsa-miR-31-3p CADM1 5.7035081317825 2.15133648211091e-05 -1.82364278704712 0.103960712759009 MirTarget;miRNATAP -0.299944585850877 1.03181165262637e-07 NA NA NA hsa-miR-335-3p CADM1 1.19503568251824 0.0938852560631551 -1.82364278704712 0.103960712759009 mirMAP -0.23045715936298 0.009835703700034 NA NA NA hsa-miR-34c-5p CADM1 2.64675661251039 0.0157394735757952 -1.82364278704712 0.103960712759009 miRanda -0.202932962149869 0.000424180913043749 NA NA NA hsa-miR-3653-3p CADM1 2.32416512605984 0.000268136992079666 -1.82364278704712 0.103960712759009 MirTarget -0.392640810443742 6.81401643252473e-05 NA NA NA hsa-miR-92a-3p CADM1 1.87892405805529 1.27013821556583e-05 -1.82364278704712 0.103960712759009 miRNATAP -0.576716975757861 8.3134464067874e-05 NA NA NA hsa-let-7g-5p CALD1 0.857251702023746 0.00647597344297273 -3.83064204238261 3.35074002836634e-08 miRNATAP -0.507479470375635 9.28875122396365e-05 NA NA NA hsa-miR-106a-5p CALD1 3.98693608217557 9.37722470816656e-07 -3.83064204238261 3.35074002836634e-08 miRNATAP -0.35597568229784 2.2691379978298e-14 NA NA NA hsa-miR-106b-5p CALD1 2.80565545918114 1.14547999022566e-09 -3.83064204238261 3.35074002836634e-08 miRNATAP -0.43314724360883 2.78744089324615e-07 NA NA NA hsa-miR-107 CALD1 1.49443409571439 0.000130594521065411 -3.83064204238261 3.35074002836634e-08 miRanda -0.350434038408351 0.000678431217848934 NA NA NA hsa-miR-142-3p CALD1 4.35304505457969 3.10014573651358e-10 -3.83064204238261 3.35074002836634e-08 miRanda -0.185281206764892 0.00100396659291762 NA NA NA hsa-miR-142-5p CALD1 3.95552531913424 1.49536283724079e-08 -3.83064204238261 3.35074002836634e-08 PITA;mirMAP -0.162717307159243 0.00379167508055824 NA NA NA hsa-miR-15a-5p CALD1 2.0535411006904 1.91108976398046e-06 -3.83064204238261 3.35074002836634e-08 miRNAWalker2_validate -0.413970440718204 6.52529275578331e-06 NA NA NA hsa-miR-16-2-3p CALD1 3.79845098071094 1.49120139344659e-13 -3.83064204238261 3.35074002836634e-08 mirMAP -0.443937762094542 1.73421704650916e-09 NA NA NA hsa-miR-17-5p CALD1 2.3269271449522 2.13987445663942e-05 -3.83064204238261 3.35074002836634e-08 TargetScan;miRNATAP -0.208064587781798 0.00427621116871273 NA NA NA hsa-miR-182-5p CALD1 5.86988712704738 1.22411588571584e-15 -3.83064204238261 3.35074002836634e-08 MirTarget -0.193864016975941 0.000189124038075249 NA NA NA hsa-miR-20a-5p CALD1 2.13553469875764 0.000181201072324354 -3.83064204238261 3.35074002836634e-08 miRNATAP -0.218000709197866 0.00184105897127506 NA NA NA hsa-miR-20b-5p CALD1 4.5662923200279 4.75238200639144e-05 -3.83064204238261 3.35074002836634e-08 miRNATAP -0.242004365478298 1.28832623481027e-12 NA NA NA hsa-miR-3065-5p CALD1 2.14185373842821 0.0609400502269891 -3.83064204238261 3.35074002836634e-08 mirMAP -0.216110178541034 5.40494226312348e-07 NA NA NA hsa-miR-34a-5p CALD1 0.830377770217786 0.0477544831885907 -3.83064204238261 3.35074002836634e-08 miRNAWalker2_validate -0.478729875032726 5.47115232554927e-07 NA NA NA hsa-miR-429 CALD1 6.39965293994036 1.96920201593608e-18 -3.83064204238261 3.35074002836634e-08 miRanda -0.439717161668995 2.68469498947677e-19 NA NA NA hsa-miR-501-3p CALD1 1.72239979688923 0.0075900263732748 -3.83064204238261 3.35074002836634e-08 TargetScan;miRNATAP -0.223356502969723 0.000310208811778176 NA NA NA hsa-miR-590-3p CALD1 2.35429565068338 2.79601879608564e-06 -3.83064204238261 3.35074002836634e-08 miRanda;mirMAP -0.262815493280182 0.000888560824135151 NA NA NA hsa-miR-93-5p CALD1 2.65964181833033 2.58315947526774e-08 -3.83064204238261 3.35074002836634e-08 miRNATAP -0.35776084890802 1.33134844165134e-05 NA NA NA hsa-let-7a-5p CALU 0.148081801547773 0.645305441523746 -0.8475888565283 0.0346041694359576 TargetScan -0.222868686310451 0.00209171065816502 NA NA NA hsa-miR-150-5p CALU 1.76769157530064 0.0593795975117846 -0.8475888565283 0.0346041694359576 MirTarget -0.118329480404886 6.69676115297647e-07 NA NA NA hsa-miR-155-5p CALU 2.81443182173772 7.42530504828797e-05 -0.8475888565283 0.0346041694359576 miRNAWalker2_validate -0.116559560946349 0.000213585081483942 NA NA NA hsa-miR-200b-3p CALU 5.56167217794639 6.43540045061709e-16 -0.8475888565283 0.0346041694359576 MirTarget;TargetScan -0.160157030514789 2.22523756566954e-07 NA NA NA hsa-miR-200c-3p CALU 6.47012025883743 2.64500707716408e-26 -0.8475888565283 0.0346041694359576 MirTarget -0.108838924612178 0.00144274968876235 NA NA NA hsa-miR-23b-3p CALU -0.581135273821923 0.190478897170459 -0.8475888565283 0.0346041694359576 mirMAP -0.212329611273823 3.51135060941384e-05 NA NA NA hsa-miR-29c-3p CALU -0.414153610337085 0.529344128062017 -0.8475888565283 0.0346041694359576 MirTarget -0.106158926624594 0.00211588665947942 NA NA NA hsa-miR-30e-5p CALU 0.780047227271616 0.0346714425913016 -0.8475888565283 0.0346041694359576 MirTarget -0.311532702097818 4.20968533836076e-07 NA NA NA hsa-miR-429 CALU 6.39965293994036 1.96920201593608e-18 -0.8475888565283 0.0346041694359576 MirTarget;PITA;miRanda -0.113179690138548 0.000101893472829594 NA NA NA hsa-miR-342-3p CAP2 1.31107714473009 0.0207211910724662 -3.09896367018549 0.000348382740526108 miRanda -0.311423514017194 0.000354409622280498 NA NA NA hsa-miR-429 CAP2 6.39965293994036 1.96920201593608e-18 -3.09896367018549 0.000348382740526108 miRanda -0.234619010785264 0.000226617234337944 NA NA NA hsa-miR-590-3p CAP2 2.35429565068338 2.79601879608564e-06 -3.09896367018549 0.000348382740526108 PITA;miRanda;mirMAP -0.318798823993138 0.00107086287564223 NA NA NA hsa-miR-10a-3p CD44 0.970411431936568 0.31667483998251 -0.250888546168612 0.702623967117811 mirMAP -0.234581759441077 8.16696486519575e-10 NA NA NA hsa-miR-15b-5p CD44 3.32329949959268 8.40210501034588e-13 -0.250888546168612 0.702623967117811 miRNAWalker2_validate -0.220420909314822 0.00448920132657962 NA NA NA hsa-miR-28-5p CD44 -0.815636722979196 0.0221199948901761 -0.250888546168612 0.702623967117811 miRanda -0.447778410207284 2.07109237116588e-05 NA NA NA hsa-miR-30a-3p CD44 -1.22212086897848 0.167565797592104 -0.250888546168612 0.702623967117811 mirMAP -0.163065626620326 9.03142709519364e-05 NA NA NA hsa-miR-30a-5p CD44 -0.768430903969183 0.320487552854215 -0.250888546168612 0.702623967117811 miRNAWalker2_validate -0.224793115132455 2.22531387608423e-06 NA NA NA hsa-miR-30c-2-3p CD44 -0.916427677918778 0.300195789569016 -0.250888546168612 0.702623967117811 MirTarget -0.152693732339066 0.000258381404667576 NA NA NA hsa-miR-328-3p CD44 -0.405365328300136 0.434443269076833 -0.250888546168612 0.702623967117811 miRNAWalker2_validate;miRTarBase -0.334895058350832 2.69498214396467e-06 NA NA NA hsa-miR-34a-5p CD44 0.830377770217786 0.0477544831885907 -0.250888546168612 0.702623967117811 miRNAWalker2_validate;miRTarBase -0.368736328233463 3.35769142445053e-05 25572695;24423412;25044638;21240262;26231042;25551284;27497057;23314380 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;Furthermore we identified CD44 as being targeted by miR-34a in MIBC cells following cisplatin treatment and increased CD44 expression could efficiently reverse the effect of miR-34a on MIBC cell proliferation colongenic potential and chemosensitivity; Cisplatin-based chemotherapy induced demethylation of miR-34a promoter and increased miR-34a expression which in turn sensitized MIBC cells to cisplatin and decreased the tumorigenicity and proliferation of cancer cells that by reducing the production of CD44;Nanocomplex-assisted delivery of miR-34a induces cell apoptosis and suppresses migration proliferation and tumor growth of breast cancer cells via targeting CD44 and a Notch-1-signaling pathway;The microRNA miR 34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44; We identified and validated CD44 as a direct and functional target of miR-34a and found that CD44 knockdown phenocopied miR-34a overexpression in inhibiting prostate cancer regeneration and metastasis;Registered report: the microRNA miR 34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44; Tumors with exogenous miR-34a showed reduced levels of CD44 expression Figure 4A and mutation of two putative miR-34a binding sites in the CD33 3' UTR partially abrogated signal repression in a luciferase assay Figure 4D;MicroRNA 34a functions as an anti metastatic microRNA and suppresses angiogenesis in bladder cancer by directly targeting CD44; In this study we focus on it that microRNA-34a functions as an anti-metastatic microRNA and suppress angiogenesis in bladder cancer by directly targeting CD44; Our study defines a major metastasis and angiogenesis suppressive role for mir-34a a microRNA functions as a tumor suppressor in bladder cancer by directly targeting CD44 which would be helpful as a therapeutic approach to block bladder cancer metastasis;Nanovesicle mediated systemic delivery of microRNA 34a for CD44 overexpressing gastric cancer stem cell therapy; MicroRNA-34a miR-34a is a promising candidate for CD44 repression-based cancer therapy as it has been reported to inhibit proliferation metastasis and survival of CD44-positive CSCs; Here we used nanovesicles containing PLI/miR complexes NVs/miR to systemically deliver miR-34a and induce miR-34a-triggered CD44 suppression in orthotopically and subcutaneously implanted tumors in nude mice;miR 34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44; The ectopic overexpression of miR-34a significantly inhibited the migration and invasive ability of osteosarcoma cells by repressing the expression of CD44; These data suggest that miR-34a plays a tumor suppressor role in the metastasis of osteosarcoma cells by repressing the expression of CD44; Therefore it can be concluded that through the inhibition of CD44 expression levels miR-34a plays a significant role in the migration and invasion of osteosarcoma cells ;;;metastasis;metastasis;metastasis;metastasis;poor survival;metastasis bladder cancer;bladder cancer;breast cancer;prostate cancer;prostate cancer;bladder cancer;gastric cancer;sarcoma hsa-miR-532-3p CD44 0.643755490841218 0.214842585969913 -0.250888546168612 0.702623967117811 miRNATAP -0.321540624171142 6.59917894489487e-06 NA NA NA hsa-miR-616-5p CD44 2.48416313933027 0.00318247475868827 -0.250888546168612 0.702623967117811 mirMAP -0.152182112772254 0.00572412441898808 NA NA NA hsa-let-7c-5p CD59 -2.03831836681378 0.0228401148731997 -0.948855962921169 0.0673706689936725 MirTarget -0.136687909789853 2.46997939854297e-05 NA NA NA hsa-miR-10a-5p CD59 -0.482300926520507 0.594608783320466 -0.948855962921169 0.0673706689936725 miRNAWalker2_validate -0.119340631259788 0.000215676755974113 NA NA NA hsa-miR-200a-3p CD59 6.336081120041 4.024313571871e-16 -0.948855962921169 0.0673706689936725 mirMAP -0.177039416341925 5.50454474949655e-07 NA NA NA hsa-miR-362-3p CD59 0.679952485897744 0.226148468488576 -0.948855962921169 0.0673706689936725 MirTarget -0.167177785299038 0.00149317853585918 NA NA NA hsa-miR-130b-3p CDH11 3.9204771543282 1.2714917955808e-11 -2.71859034741409 0.00843049688225146 mirMAP -0.325728153062724 0.000895302601953724 NA NA NA hsa-miR-16-2-3p CDH11 3.79845098071094 1.49120139344659e-13 -2.71859034741409 0.00843049688225146 mirMAP -0.798467102081339 4.89052056929287e-14 NA NA NA hsa-miR-200b-3p CDH11 5.56167217794639 6.43540045061709e-16 -2.71859034741409 0.00843049688225146 TargetScan -0.36980388813511 4.19309498405349e-06 NA NA NA hsa-miR-224-3p CDH11 2.84876340814503 0.000179138399939161 -2.71859034741409 0.00843049688225146 mirMAP -0.23963949278843 0.00185711980618134 NA NA NA hsa-miR-32-3p CDH11 2.20477794939766 0.0392771274032852 -2.71859034741409 0.00843049688225146 mirMAP -0.362584798181036 0.000166211678320865 NA NA NA hsa-miR-362-3p CDH11 0.679952485897744 0.226148468488576 -2.71859034741409 0.00843049688225146 miRanda -0.32980310732199 0.00172707895339301 NA NA NA hsa-miR-429 CDH11 6.39965293994036 1.96920201593608e-18 -2.71859034741409 0.00843049688225146 PITA;miRanda -0.312128267326301 3.33313824087005e-05 NA NA NA hsa-miR-454-3p CDH11 1.40269869979902 0.00366085847011367 -2.71859034741409 0.00843049688225146 mirMAP -0.482197790679695 6.97861192073659e-05 NA NA NA hsa-miR-500a-5p CDH11 0.0170829425378565 0.973960207660626 -2.71859034741409 0.00843049688225146 mirMAP -0.293236198827984 0.0097097867088192 NA NA NA hsa-miR-576-5p CDH11 1.30320223793746 0.00648929463912994 -2.71859034741409 0.00843049688225146 PITA;mirMAP;miRNATAP -0.449089813972263 0.000249478695134832 NA NA NA hsa-miR-590-3p CDH11 2.35429565068338 2.79601879608564e-06 -2.71859034741409 0.00843049688225146 miRanda;mirMAP -0.486802343260666 2.25826413999235e-05 NA NA NA hsa-miR-944 CDH11 7.20925181386398 0.000823207457340648 -2.71859034741409 0.00843049688225146 mirMAP -0.149344282084579 7.01789995712093e-06 NA NA NA hsa-miR-150-3p CDH2 1.65258591448117 0.058477568382345 -1.61412943282775 0.259070483638014 MirTarget;miRNATAP -0.354593308521729 0.000186655655293548 NA NA NA hsa-miR-155-5p CDH2 2.81443182173772 7.42530504828797e-05 -1.61412943282775 0.259070483638014 miRNAWalker2_validate -0.308324194303959 0.00634841367860939 NA NA NA hsa-miR-361-3p CDH2 0.805698609170807 0.0418491665498322 -1.61412943282775 0.259070483638014 miRNATAP -0.961317274194362 2.76588475166825e-06 NA NA NA hsa-miR-452-5p CDH2 2.45466810475361 0.00114794259949532 -1.61412943282775 0.259070483638014 miRNATAP -0.541048785499491 2.58217281520332e-07 NA NA NA hsa-miR-590-3p CDH2 2.35429565068338 2.79601879608564e-06 -1.61412943282775 0.259070483638014 miRanda -0.461445846808317 0.0038730759008266 NA NA NA hsa-miR-642a-5p CDH2 3.38585273752088 0.000272015814573312 -1.61412943282775 0.259070483638014 MirTarget -0.375709760002489 0.000441803865507293 NA NA NA hsa-miR-155-5p CDH6 2.81443182173772 7.42530504828797e-05 -2.03558837194243 0.0725884242894861 miRNAWalker2_validate -0.403929236597007 5.29284673101207e-06 NA NA NA hsa-miR-15b-3p CDH6 3.57530146629867 5.89922785773482e-11 -2.03558837194243 0.0725884242894861 mirMAP -0.32776820462623 0.00421433209512584 NA NA NA hsa-miR-24-1-5p CDH6 -0.638925193416348 0.236125310537158 -2.03558837194243 0.0725884242894861 MirTarget -0.471130909034144 7.79639852351515e-05 NA NA NA hsa-miR-24-2-5p CDH6 2.06986947133452 5.98496897647448e-05 -2.03558837194243 0.0725884242894861 MirTarget -0.474975326249983 0.000118951884673639 NA NA NA hsa-miR-330-3p CDH6 2.49094236945806 0.000129367003214715 -2.03558837194243 0.0725884242894861 miRNATAP -0.510322617622056 1.34787956590358e-07 NA NA NA hsa-miR-33a-3p CDH6 2.06269680799532 0.00156436055383943 -2.03558837194243 0.0725884242894861 mirMAP -0.309449142217711 0.00168255362172494 NA NA NA hsa-miR-452-5p CDH6 2.45466810475361 0.00114794259949532 -2.03558837194243 0.0725884242894861 mirMAP -0.367592337686115 1.1696876641335e-05 NA NA NA hsa-miR-944 CDH6 7.20925181386398 0.000823207457340648 -2.03558837194243 0.0725884242894861 PITA;miRNATAP -0.326102145205993 3.03939808602299e-21 NA NA NA hsa-let-7a-5p COL11A1 0.148081801547773 0.645305441523746 -0.788855321813521 0.686347859403413 TargetScan -1.03101249846916 0.00351361369395343 NA NA NA hsa-miR-141-3p COL11A1 7.30474126597325 1.45115996357606e-24 -0.788855321813521 0.686347859403413 miRNATAP -0.41540379798351 0.00365799662531711 NA NA NA hsa-miR-16-2-3p COL11A1 3.79845098071094 1.49120139344659e-13 -0.788855321813521 0.686347859403413 MirTarget;mirMAP -0.598545770060638 0.00391876664998404 NA NA NA hsa-miR-200a-3p COL11A1 6.336081120041 4.024313571871e-16 -0.788855321813521 0.686347859403413 miRNATAP -0.473021719168829 0.000435832454801496 NA NA NA hsa-miR-200c-5p COL11A1 5.34093243595571 3.35355119348069e-10 -0.788855321813521 0.686347859403413 MirTarget;miRNATAP -0.456724254780972 0.00314664504374739 NA NA NA hsa-miR-26a-5p COL11A1 -0.352368463397074 0.362040749917446 -0.788855321813521 0.686347859403413 miRNATAP -1.20746766471167 2.9017007994755e-05 NA NA NA hsa-miR-29b-3p COL11A1 0.666547117072858 0.234055379278093 -0.788855321813521 0.686347859403413 MirTarget;miRNATAP -0.596383446912905 0.00263521194910138 NA NA NA hsa-miR-29c-3p COL11A1 -0.414153610337085 0.529344128062017 -0.788855321813521 0.686347859403413 MirTarget;miRNATAP -0.776600093210765 3.16074921808411e-06 NA NA NA hsa-miR-32-5p COL11A1 2.93035124381469 5.00149131394151e-10 -0.788855321813521 0.686347859403413 MirTarget -0.801858809385718 0.000464563147967805 NA NA NA hsa-miR-362-3p COL11A1 0.679952485897744 0.226148468488576 -0.788855321813521 0.686347859403413 miRanda -0.680691313361502 0.000583035153878767 NA NA NA hsa-miR-363-3p COL11A1 4.27232887548977 8.53979362839458e-06 -0.788855321813521 0.686347859403413 MirTarget -0.352013544697041 0.00190721204747534 NA NA NA hsa-miR-429 COL11A1 6.39965293994036 1.96920201593608e-18 -0.788855321813521 0.686347859403413 miRanda -0.389644846590137 0.00636215248843538 NA NA NA hsa-miR-142-3p COL12A1 4.35304505457969 3.10014573651358e-10 -2.1321432334 0.0346678550324686 miRanda -0.273648874124357 0.000651973740761992 NA NA NA hsa-miR-15a-5p COL12A1 2.0535411006904 1.91108976398046e-06 -2.1321432334 0.0346678550324686 MirTarget;miRNATAP -0.522819655068365 6.9367832161131e-05 NA NA NA hsa-miR-15b-5p COL12A1 3.32329949959268 8.40210501034588e-13 -2.1321432334 0.0346678550324686 MirTarget;miRNATAP -0.439085867699426 0.000228501077516514 NA NA NA hsa-miR-16-5p COL12A1 2.93575808220754 2.15436817162977e-10 -2.1321432334 0.0346678550324686 MirTarget;miRNATAP -0.506610720602489 2.56788527467966e-05 NA NA NA hsa-miR-25-3p COL12A1 1.12623030168869 0.00311079344417173 -2.1321432334 0.0346678550324686 miRNATAP -0.72683794866852 1.32182543701449e-06 NA NA NA hsa-miR-30d-5p COL12A1 0.302504510257496 0.380193536606962 -2.1321432334 0.0346678550324686 mirMAP -0.596112723422633 0.000437606615150177 NA NA NA hsa-miR-32-5p COL12A1 2.93035124381469 5.00149131394151e-10 -2.1321432334 0.0346678550324686 miRNATAP -0.378746137284815 0.0014492434073333 NA NA NA hsa-miR-342-3p COL12A1 1.31107714473009 0.0207211910724662 -2.1321432334 0.0346678550324686 miRanda -0.321162492572504 0.00149459653058116 NA NA NA hsa-miR-34a-5p COL12A1 0.830377770217786 0.0477544831885907 -2.1321432334 0.0346678550324686 MirTarget;miRNATAP -0.584862061376689 1.97686186079586e-05 NA NA NA hsa-miR-502-3p COL12A1 -0.102232623565007 0.80889202592629 -2.1321432334 0.0346678550324686 PITA -0.589179860551753 1.55324398640316e-05 NA NA NA hsa-miR-532-5p COL12A1 -0.297424983759107 0.503934707453099 -2.1321432334 0.0346678550324686 PITA -0.574993877169761 8.4524781465909e-06 NA NA NA hsa-miR-590-3p COL12A1 2.35429565068338 2.79601879608564e-06 -2.1321432334 0.0346678550324686 miRanda -0.456996593527318 4.68454338048145e-05 NA NA NA hsa-miR-9-5p COL12A1 1.79620806707734 0.14526963042518 -2.1321432334 0.0346678550324686 miRNAWalker2_validate;miRNATAP -0.129408033718545 0.00521361699152156 NA NA NA hsa-miR-3065-3p COL16A1 1.89496019576082 0.0308154823923145 -1.04162624184439 0.214220959870072 MirTarget;miRNATAP -0.145385411696392 0.00706218276754846 NA NA NA hsa-let-7d-5p COL1A1 0.831142050231414 0.0126955498524287 -1.84056354039351 0.0428283936196076 miRNATAP -0.736242595043802 2.36678678285063e-06 NA NA NA hsa-let-7f-5p COL1A1 0.971961126099146 0.0240319857511033 -1.84056354039351 0.0428283936196076 miRNATAP -0.330988375714268 0.00619664736510643 NA NA NA hsa-let-7g-5p COL1A1 0.857251702023746 0.00647597344297273 -1.84056354039351 0.0428283936196076 miRNATAP -0.78141081106779 2.40131824211618e-06 NA NA NA hsa-miR-106a-5p COL1A1 3.98693608217557 9.37722470816656e-07 -1.84056354039351 0.0428283936196076 mirMAP -0.270034033004211 1.21948821992489e-05 NA NA NA hsa-miR-106b-5p COL1A1 2.80565545918114 1.14547999022566e-09 -1.84056354039351 0.0428283936196076 mirMAP -0.527805230776855 1.12907897624131e-06 NA NA NA hsa-miR-107 COL1A1 1.49443409571439 0.000130594521065411 -1.84056354039351 0.0428283936196076 PITA;miRanda -0.361912286670645 0.00641596085953541 NA NA NA hsa-miR-17-5p COL1A1 2.3269271449522 2.13987445663942e-05 -1.84056354039351 0.0428283936196076 mirMAP -0.330176665385721 0.00039145185357986 NA NA NA hsa-miR-196a-5p COL1A1 2.71653705877687 0.0233843546205134 -1.84056354039351 0.0428283936196076 miRNATAP -0.140254497250573 0.00102160140385264 NA NA NA hsa-miR-20a-5p COL1A1 2.13553469875764 0.000181201072324354 -1.84056354039351 0.0428283936196076 mirMAP -0.311754473971363 0.000505394044383958 NA NA NA hsa-miR-20b-5p COL1A1 4.5662923200279 4.75238200639144e-05 -1.84056354039351 0.0428283936196076 mirMAP -0.141592361374589 0.00173848234748365 NA NA NA hsa-miR-23a-5p COL1A1 2.86720096840797 0.000290788677230784 -1.84056354039351 0.0428283936196076 mirMAP -0.174097288435129 0.00705242994788015 NA NA NA hsa-miR-29c-3p COL1A1 -0.414153610337085 0.529344128062017 -1.84056354039351 0.0428283936196076 miRNAWalker2_validate;miRTarBase;miRNATAP -0.245497936543541 0.00175768447884849 NA NA NA hsa-miR-30d-3p COL1A1 -0.0740421896025512 0.857423650167556 -1.84056354039351 0.0428283936196076 mirMAP -0.508798584746145 5.5470869958132e-05 NA NA NA hsa-miR-30e-3p COL1A1 -0.0362193022195196 0.932577027239525 -1.84056354039351 0.0428283936196076 mirMAP -0.479293746322041 7.87782827939094e-05 NA NA NA hsa-miR-330-3p COL1A1 2.49094236945806 0.000129367003214715 -1.84056354039351 0.0428283936196076 mirMAP -0.268905839530123 0.000626561404686276 NA NA NA hsa-miR-361-3p COL1A1 0.805698609170807 0.0418491665498322 -1.84056354039351 0.0428283936196076 PITA -0.553999693563706 2.33794100267697e-05 NA NA NA hsa-miR-532-3p COL1A1 0.643755490841218 0.214842585969913 -1.84056354039351 0.0428283936196076 PITA;miRNATAP -0.262844379629406 0.00867649430321237 NA NA NA hsa-miR-590-3p COL1A1 2.35429565068338 2.79601879608564e-06 -1.84056354039351 0.0428283936196076 miRanda -0.371129696394564 0.00024778150914842 NA NA NA hsa-miR-616-5p COL1A1 2.48416313933027 0.00318247475868827 -1.84056354039351 0.0428283936196076 mirMAP;miRNATAP -0.203770345455775 0.00772746556309996 NA NA NA hsa-miR-625-5p COL1A1 2.02792641909347 0.000935142379948297 -1.84056354039351 0.0428283936196076 MirTarget -0.259427071348568 0.00211430009957569 NA NA NA hsa-miR-92a-1-5p COL1A1 2.14839829606717 0.0015466735813532 -1.84056354039351 0.0428283936196076 MirTarget -0.425084123297027 1.03247302673834e-08 NA NA NA hsa-miR-93-5p COL1A1 2.65964181833033 2.58315947526774e-08 -1.84056354039351 0.0428283936196076 mirMAP -0.402728518614805 0.000140978199966934 NA NA NA hsa-let-7d-5p COL1A2 0.831142050231414 0.0126955498524287 -2.4074903809474 0.0132038858386377 MirTarget;miRNATAP -0.811305049738731 1.16473245675138e-06 NA NA NA hsa-let-7f-1-3p COL1A2 1.61507869803314 0.00069342464777815 -2.4074903809474 0.0132038858386377 MirTarget -0.480049449238721 3.40222745923023e-05 NA NA NA hsa-let-7f-5p COL1A2 0.971961126099146 0.0240319857511033 -2.4074903809474 0.0132038858386377 MirTarget;miRNATAP -0.388783382460893 0.00264625141571876 NA NA NA hsa-let-7g-5p COL1A2 0.857251702023746 0.00647597344297273 -2.4074903809474 0.0132038858386377 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.826839279434069 3.19062936758908e-06 NA NA NA hsa-miR-193a-3p COL1A2 0.646392169474854 0.207134343676122 -2.4074903809474 0.0132038858386377 miRanda -0.341368917940043 0.00163594927400134 NA NA NA hsa-miR-196a-5p COL1A2 2.71653705877687 0.0233843546205134 -2.4074903809474 0.0132038858386377 MirTarget;miRNATAP -0.156993010102596 0.00059041327695629 NA NA NA hsa-miR-19a-3p COL1A2 2.17020503944519 0.00122084653711062 -2.4074903809474 0.0132038858386377 MirTarget -0.22504954970786 0.0060052581550391 NA NA NA hsa-miR-19b-3p COL1A2 1.67581705793313 0.000858910586302716 -2.4074903809474 0.0132038858386377 MirTarget -0.417555305209778 0.000132269815918335 NA NA NA hsa-miR-25-3p COL1A2 1.12623030168869 0.00311079344417173 -2.4074903809474 0.0132038858386377 MirTarget;miRNATAP -0.669108328095464 3.97972238969148e-06 NA NA NA hsa-miR-29c-3p COL1A2 -0.414153610337085 0.529344128062017 -2.4074903809474 0.0132038858386377 miRNAWalker2_validate;miRTarBase;miRNATAP -0.253827571070811 0.0025379069504055 NA NA NA hsa-miR-30d-3p COL1A2 -0.0740421896025512 0.857423650167556 -2.4074903809474 0.0132038858386377 MirTarget -0.512349667849357 0.000153814514387612 NA NA NA hsa-miR-30e-3p COL1A2 -0.0362193022195196 0.932577027239525 -2.4074903809474 0.0132038858386377 MirTarget -0.437000646443569 0.000809375601769536 NA NA NA hsa-miR-32-3p COL1A2 2.20477794939766 0.0392771274032852 -2.4074903809474 0.0132038858386377 miRNATAP -0.423477271504932 2.53272017268217e-06 NA NA NA hsa-miR-32-5p COL1A2 2.93035124381469 5.00149131394151e-10 -2.4074903809474 0.0132038858386377 MirTarget;miRNATAP -0.615997519864761 4.73261950924558e-08 NA NA NA hsa-miR-330-5p COL1A2 2.25110496739954 0.000275527655397415 -2.4074903809474 0.0132038858386377 miRanda -0.281370092303073 0.00148399561137761 NA NA NA hsa-miR-33a-3p COL1A2 2.06269680799532 0.00156436055383943 -2.4074903809474 0.0132038858386377 MirTarget -0.326830155888293 0.000104523428736575 NA NA NA hsa-miR-342-3p COL1A2 1.31107714473009 0.0207211910724662 -2.4074903809474 0.0132038858386377 miRanda;miRNATAP -0.301504696149465 0.00198450180149318 NA NA NA hsa-miR-363-3p COL1A2 4.27232887548977 8.53979362839458e-06 -2.4074903809474 0.0132038858386377 MirTarget -0.208073863653219 0.000227929666222705 NA NA NA hsa-miR-590-3p COL1A2 2.35429565068338 2.79601879608564e-06 -2.4074903809474 0.0132038858386377 miRanda -0.396794894969357 0.00025369854986237 NA NA NA hsa-miR-7-5p COL1A2 3.59831747997243 0.000676336260217879 -2.4074903809474 0.0132038858386377 miRNATAP -0.202706097797999 0.00147098697303035 NA NA NA hsa-miR-92a-3p COL1A2 1.87892405805529 1.27013821556583e-05 -2.4074903809474 0.0132038858386377 MirTarget;miRNATAP -0.591859006461079 2.95063044958949e-06 NA NA NA hsa-miR-92b-3p COL1A2 1.69303761469782 0.0103484911955574 -2.4074903809474 0.0132038858386377 MirTarget;miRNATAP -0.280225522418452 0.000764612270543414 NA NA NA hsa-let-7d-5p COL3A1 0.831142050231414 0.0126955498524287 -2.64946665554891 0.00755899616273038 MirTarget;miRNATAP -0.90482313676384 1.0033314414842e-07 NA NA NA hsa-let-7f-5p COL3A1 0.971961126099146 0.0240319857511033 -2.64946665554891 0.00755899616273038 MirTarget;miRNATAP -0.342370540396546 0.009720205805624 NA NA NA hsa-let-7g-5p COL3A1 0.857251702023746 0.00647597344297273 -2.64946665554891 0.00755899616273038 MirTarget;miRNATAP -0.786696469363227 1.51338467679067e-05 NA NA NA hsa-miR-107 COL3A1 1.49443409571439 0.000130594521065411 -2.64946665554891 0.00755899616273038 miRanda -0.452413107971354 0.00181143265282339 NA NA NA hsa-miR-128-3p COL3A1 1.36248409467631 0.00408435995818078 -2.64946665554891 0.00755899616273038 MirTarget -0.358344816316959 0.00266608561399334 NA NA NA hsa-miR-141-5p COL3A1 7.13744624551943 4.06877058732583e-26 -2.64946665554891 0.00755899616273038 MirTarget -0.547606017191674 1.33449344648606e-13 NA NA NA hsa-miR-16-2-3p COL3A1 3.79845098071094 1.49120139344659e-13 -2.64946665554891 0.00755899616273038 MirTarget -0.715340859641064 2.99922336418e-12 NA NA NA hsa-miR-196a-5p COL3A1 2.71653705877687 0.0233843546205134 -2.64946665554891 0.00755899616273038 MirTarget;miRNATAP -0.175613599486289 0.000164192599368092 NA NA NA hsa-miR-29b-3p COL3A1 0.666547117072858 0.234055379278093 -2.64946665554891 0.00755899616273038 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.310849123195915 0.00212339830690245 NA NA NA hsa-miR-330-5p COL3A1 2.25110496739954 0.000275527655397415 -2.64946665554891 0.00755899616273038 miRanda -0.365246875539485 4.95626311245393e-05 NA NA NA hsa-miR-335-3p COL3A1 1.19503568251824 0.0938852560631551 -2.64946665554891 0.00755899616273038 mirMAP -0.258511056405655 0.00106085626812628 NA NA NA hsa-miR-429 COL3A1 6.39965293994036 1.96920201593608e-18 -2.64946665554891 0.00755899616273038 miRanda -0.322573871614928 7.77710706257695e-06 NA NA NA hsa-miR-590-3p COL3A1 2.35429565068338 2.79601879608564e-06 -2.64946665554891 0.00755899616273038 miRanda;mirMAP -0.493607342726183 7.54241548388033e-06 NA NA NA hsa-miR-590-5p COL3A1 1.51400888103768 0.0023888567923017 -2.64946665554891 0.00755899616273038 miRanda -0.440756542181513 9.23254579915772e-05 NA NA NA hsa-let-7a-5p COL4A1 0.148081801547773 0.645305441523746 -1.16864065099484 0.0984791802100705 TargetScan;miRNATAP -0.395216601708053 0.00200095586375547 NA NA NA hsa-let-7b-3p COL4A1 0.589364128513318 0.200507534602851 -1.16864065099484 0.0984791802100705 miRNATAP -0.323866459414722 0.000215138506878023 NA NA NA hsa-let-7b-5p COL4A1 -0.189422992330471 0.651878220048983 -1.16864065099484 0.0984791802100705 miRNATAP -0.376516880807364 9.17121881705376e-05 NA NA NA hsa-let-7g-5p COL4A1 0.857251702023746 0.00647597344297273 -1.16864065099484 0.0984791802100705 miRNATAP -0.521878665910767 5.47715731470755e-05 NA NA NA hsa-miR-16-5p COL4A1 2.93575808220754 2.15436817162977e-10 -1.16864065099484 0.0984791802100705 miRNAWalker2_validate -0.337832000672797 6.10778641796011e-05 NA NA NA hsa-miR-29c-3p COL4A1 -0.414153610337085 0.529344128062017 -1.16864065099484 0.0984791802100705 miRNAWalker2_validate;miRTarBase;miRNATAP -0.337967010855051 1.68085879155805e-08 NA NA NA hsa-miR-3065-5p COL4A1 2.14185373842821 0.0609400502269891 -1.16864065099484 0.0984791802100705 miRNATAP -0.147266374061876 0.000705791993274342 NA NA NA hsa-miR-362-3p COL4A1 0.679952485897744 0.226148468488576 -1.16864065099484 0.0984791802100705 miRanda -0.251903181276386 0.000441751885714519 NA NA NA hsa-miR-429 COL4A1 6.39965293994036 1.96920201593608e-18 -1.16864065099484 0.0984791802100705 miRanda;miRNATAP -0.247799101573786 1.22789780513352e-06 NA NA NA hsa-miR-590-3p COL4A1 2.35429565068338 2.79601879608564e-06 -1.16864065099484 0.0984791802100705 miRanda -0.222848822908421 0.00481327470873168 NA NA NA hsa-miR-99a-5p COL4A1 -2.72139054000803 0.00621971944534118 -1.16864065099484 0.0984791802100705 miRNAWalker2_validate -0.160770833475788 5.25644974578457e-05 NA NA NA hsa-let-7a-5p COL4A2 0.148081801547773 0.645305441523746 -1.9722594684363 0.00704429653435828 TargetScan;miRNATAP -0.368446948360621 0.0056180383454478 NA NA NA hsa-let-7b-5p COL4A2 -0.189422992330471 0.651878220048983 -1.9722594684363 0.00704429653435828 miRNATAP -0.320323636043953 0.00141991339139528 NA NA NA hsa-let-7g-5p COL4A2 0.857251702023746 0.00647597344297273 -1.9722594684363 0.00704429653435828 miRNATAP -0.49045124827628 0.000271321261445424 NA NA NA hsa-miR-155-5p COL4A2 2.81443182173772 7.42530504828797e-05 -1.9722594684363 0.00704429653435828 miRNAWalker2_validate -0.174348665871742 0.00262996500334362 NA NA NA hsa-miR-16-5p COL4A2 2.93575808220754 2.15436817162977e-10 -1.9722594684363 0.00704429653435828 miRNAWalker2_validate -0.365920993931199 2.85031407247609e-05 NA NA NA hsa-miR-29c-3p COL4A2 -0.414153610337085 0.529344128062017 -1.9722594684363 0.00704429653435828 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.316970244389103 3.99064158591322e-07 NA NA NA hsa-miR-9-5p COL4A2 1.79620806707734 0.14526963042518 -1.9722594684363 0.00704429653435828 MirTarget;miRNATAP -0.101015090031277 0.00265111086723359 NA NA NA hsa-miR-192-5p COL5A1 1.77716187978541 0.113485496183047 -2.3278978155346 0.0220673416121582 miRNATAP -0.203078046074021 6.74836924159492e-05 NA NA NA hsa-miR-25-3p COL5A1 1.12623030168869 0.00311079344417173 -2.3278978155346 0.0220673416121582 miRNATAP -0.671960661322446 9.7834897131097e-06 NA NA NA hsa-miR-29c-3p COL5A1 -0.414153610337085 0.529344128062017 -2.3278978155346 0.0220673416121582 MirTarget;miRNATAP -0.255859515460249 0.00364511342287274 NA NA NA hsa-miR-3065-3p COL5A1 1.89496019576082 0.0308154823923145 -2.3278978155346 0.0220673416121582 miRNATAP -0.243005990799136 0.000198444959902048 NA NA NA hsa-miR-3653-3p COL5A1 2.32416512605984 0.000268136992079666 -2.3278978155346 0.0220673416121582 MirTarget -0.29693971011634 0.000959440208210614 NA NA NA hsa-miR-590-3p COL5A1 2.35429565068338 2.79601879608564e-06 -2.3278978155346 0.0220673416121582 PITA;miRanda;mirMAP;miRNATAP -0.316319099122429 0.00551675817129431 NA NA NA hsa-miR-92a-3p COL5A1 1.87892405805529 1.27013821556583e-05 -2.3278978155346 0.0220673416121582 miRNATAP -0.363418306950173 0.00669443804511927 NA NA NA hsa-let-7a-5p COL5A2 0.148081801547773 0.645305441523746 -1.30416413139313 0.157063388491223 MirTarget;TargetScan;miRNATAP -0.445959611430584 0.00757019373475821 NA NA NA hsa-let-7d-5p COL5A2 0.831142050231414 0.0126955498524287 -1.30416413139313 0.157063388491223 MirTarget;miRNATAP -0.588947214079224 0.000213231374818981 NA NA NA hsa-let-7g-5p COL5A2 0.857251702023746 0.00647597344297273 -1.30416413139313 0.157063388491223 MirTarget;miRNATAP -0.782412917458291 3.12925658881458e-06 NA NA NA hsa-miR-16-2-3p COL5A2 3.79845098071094 1.49120139344659e-13 -1.30416413139313 0.157063388491223 MirTarget;mirMAP -0.552643982587586 8.70004732232617e-09 NA NA NA hsa-miR-3065-5p COL5A2 2.14185373842821 0.0609400502269891 -1.30416413139313 0.157063388491223 MirTarget;mirMAP -0.199161177560616 0.000434559964890779 NA NA NA hsa-miR-32-3p COL5A2 2.20477794939766 0.0392771274032852 -1.30416413139313 0.157063388491223 mirMAP -0.278238698889644 0.00119843132713056 NA NA NA hsa-miR-34a-5p COL5A2 0.830377770217786 0.0477544831885907 -1.30416413139313 0.157063388491223 MirTarget -0.465752615915037 0.000201820127785417 NA NA NA hsa-miR-590-3p COL5A2 2.35429565068338 2.79601879608564e-06 -1.30416413139313 0.157063388491223 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.285333911145809 0.00561200914006343 NA NA NA hsa-miR-3065-3p COL5A3 1.89496019576082 0.0308154823923145 -1.13470175099166 0.247042135287664 MirTarget;miRNATAP -0.186030970198022 0.00315446381372204 NA NA NA hsa-miR-362-3p COL5A3 0.679952485897744 0.226148468488576 -1.13470175099166 0.247042135287664 miRanda -0.282410688863997 0.0045998613088183 NA NA NA hsa-miR-429 COL5A3 6.39965293994036 1.96920201593608e-18 -1.13470175099166 0.247042135287664 miRanda -0.416215947254203 2.89242509318761e-09 NA NA NA hsa-miR-625-5p COL5A3 2.02792641909347 0.000935142379948297 -1.13470175099166 0.247042135287664 mirMAP -0.39635166060267 1.09371764975868e-05 NA NA NA hsa-miR-130a-5p COL6A3 1.58028512890005 0.024346333013728 -3.07518364362208 0.000679056442919429 miRNATAP -0.25053945495258 0.000793393076413353 NA NA NA hsa-miR-362-3p COL6A3 0.679952485897744 0.226148468488576 -3.07518364362208 0.000679056442919429 miRanda -0.312148326753103 0.000740193451939931 NA NA NA hsa-miR-429 COL6A3 6.39965293994036 1.96920201593608e-18 -3.07518364362208 0.000679056442919429 miRNATAP -0.331218235808428 4.74841912512098e-07 NA NA NA hsa-miR-590-3p COL6A3 2.35429565068338 2.79601879608564e-06 -3.07518364362208 0.000679056442919429 miRanda -0.393167889977125 0.00010451248703474 NA NA NA hsa-miR-3065-3p COL7A1 1.89496019576082 0.0308154823923145 3.61017455595981 0.000594648273461976 MirTarget;miRNATAP -0.306560701931121 5.59182870850621e-06 NA NA NA hsa-miR-106a-5p COL8A2 3.98693608217557 9.37722470816656e-07 -0.623983269806004 0.47257399462785 mirMAP -0.206506510788352 0.000482931840868527 NA NA NA hsa-miR-106b-5p COL8A2 2.80565545918114 1.14547999022566e-09 -0.623983269806004 0.47257399462785 mirMAP -0.492298559900783 1.93801118380353e-06 NA NA NA hsa-miR-194-3p COL8A2 1.91743783341496 0.105383373371284 -0.623983269806004 0.47257399462785 MirTarget -0.239438315994747 4.76612678371343e-09 NA NA NA hsa-miR-20b-5p COL8A2 4.5662923200279 4.75238200639144e-05 -0.623983269806004 0.47257399462785 mirMAP -0.139403846104731 0.00120891493933797 NA NA NA hsa-miR-3127-5p COL8A2 0.941647403878801 0.124512093133103 -0.623983269806004 0.47257399462785 MirTarget -0.35203821915156 1.02671424398238e-05 NA NA NA hsa-miR-582-5p COL8A2 0.685177900016753 0.447761540297692 -0.623983269806004 0.47257399462785 PITA -0.151730007072177 0.00533057124509659 NA NA NA hsa-miR-592 COL8A2 2.80403350008555 0.0293520213681333 -0.623983269806004 0.47257399462785 MirTarget;PITA;miRNATAP -0.297847158624551 5.84288886019676e-11 NA NA NA hsa-miR-625-5p COL8A2 2.02792641909347 0.000935142379948297 -0.623983269806004 0.47257399462785 MirTarget -0.236304034916992 0.00332912659284207 NA NA NA hsa-miR-23b-3p COPA -0.581135273821923 0.190478897170459 0.323063846980837 0.26974382941358 miRNAWalker2_validate -0.120800696514767 0.00124177592475947 NA NA NA hsa-miR-16-2-3p CTGF 3.79845098071094 1.49120139344659e-13 -4.33545045467629 1.68684819424562e-05 MirTarget -0.739596116076892 1.89677421696511e-12 NA NA NA hsa-miR-18a-5p CTGF 3.90770175770219 9.15298615034137e-10 -4.33545045467629 1.68684819424562e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.473479002391093 4.90104635491302e-08 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling poor survival glioblastoma hsa-miR-19a-3p CTGF 2.17020503944519 0.00122084653711062 -4.33545045467629 1.68684819424562e-05 MirTarget;miRNATAP -0.480864733842777 1.07483303362832e-08 NA NA NA hsa-miR-19b-3p CTGF 1.67581705793313 0.000858910586302716 -4.33545045467629 1.68684819424562e-05 MirTarget;miRNATAP -0.625967163512526 3.01248201266609e-08 NA NA NA hsa-miR-205-5p CTGF 8.08298115900323 3.83045179398654e-07 -4.33545045467629 1.68684819424562e-05 miRNAWalker2_validate;miRTarBase -0.246116307983091 7.1964003979013e-13 NA NA NA hsa-miR-330-3p CTGF 2.49094236945806 0.000129367003214715 -4.33545045467629 1.68684819424562e-05 MirTarget;PITA;miRNATAP -0.26608478138308 0.0026140494750974 NA NA NA hsa-miR-486-5p CTGF 1.10898145177457 0.309287974401609 -4.33545045467629 1.68684819424562e-05 miRanda -0.143227412399099 0.00685905007100677 NA NA NA hsa-miR-590-3p CTGF 2.35429565068338 2.79601879608564e-06 -4.33545045467629 1.68684819424562e-05 PITA;miRanda -0.390815254563478 0.000592418225269412 NA NA NA hsa-miR-148b-3p CTHRC1 1.75622244535669 8.84414356040579e-08 1.03066232923987 0.24904452351538 miRNAWalker2_validate -0.456306798146187 0.00314047028354663 NA NA NA hsa-miR-30c-5p CTHRC1 0.38723991118075 0.348605235643473 1.03066232923987 0.24904452351538 MirTarget -0.429408156434748 0.000530176851420371 NA NA NA hsa-miR-30d-5p CTHRC1 0.302504510257496 0.380193536606962 1.03066232923987 0.24904452351538 MirTarget -0.499689140143806 0.000858409334797709 NA NA NA hsa-miR-30e-5p CTHRC1 0.780047227271616 0.0346714425913016 1.03066232923987 0.24904452351538 MirTarget -0.740457869876301 6.45680096453109e-08 NA NA NA hsa-miR-130a-5p CXCL12 1.58028512890005 0.024346333013728 -5.99088601475679 5.43950830992156e-09 miRNATAP -0.505519359679823 2.3119450317532e-09 NA NA NA hsa-miR-141-3p CXCL12 7.30474126597325 1.45115996357606e-24 -5.99088601475679 5.43950830992156e-09 miRNATAP -0.674130526940929 1.51636576540183e-20 NA NA NA hsa-miR-16-2-3p CXCL12 3.79845098071094 1.49120139344659e-13 -5.99088601475679 5.43950830992156e-09 mirMAP -0.959392997103623 1.0554635748104e-19 NA NA NA hsa-miR-200a-3p CXCL12 6.336081120041 4.024313571871e-16 -5.99088601475679 5.43950830992156e-09 miRNATAP -0.450261578521708 2.28833051106536e-10 NA NA NA hsa-miR-222-3p CXCL12 1.54730827524553 0.0223014220569407 -5.99088601475679 5.43950830992156e-09 MirTarget -0.259839340454368 0.00316805636672831 NA NA NA hsa-miR-23a-3p CXCL12 0.925125296618358 0.0127293543936914 -5.99088601475679 5.43950830992156e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.658058424773125 4.88911203381657e-05 25322765 MiR-23a suppressed the transcription of RUNX2 and CXCL12 by binding to the 3' UTRs of these mRNAs; The cellular function of miR-23a is RUNX2/CXCL12-dependent and the overexpression of RUNX2 or CXCL12 rescued the impaired cell growth migration and invasion induced by miR-23a sarcoma hsa-miR-301a-3p CXCL12 1.99338115332667 0.000813358604963724 -5.99088601475679 5.43950830992156e-09 miRNATAP -0.50598532147778 2.74857297908787e-07 NA NA NA hsa-miR-30b-5p CXCL12 0.0238659735605804 0.953223658270319 -5.99088601475679 5.43950830992156e-09 mirMAP -0.402788751348827 0.00693758554429875 NA NA NA hsa-miR-30c-5p CXCL12 0.38723991118075 0.348605235643473 -5.99088601475679 5.43950830992156e-09 mirMAP -0.44510214511446 0.00237875342357166 NA NA NA hsa-miR-31-5p CXCL12 7.15600983164746 6.64190917357724e-10 -5.99088601475679 5.43950830992156e-09 miRNAWalker2_validate -0.310368147336752 1.72532778662393e-10 NA NA NA hsa-miR-320b CXCL12 0.20205459771295 0.727216419960509 -5.99088601475679 5.43950830992156e-09 miRanda -0.320250440208556 0.00198355012276615 NA NA NA hsa-miR-429 CXCL12 6.39965293994036 1.96920201593608e-18 -5.99088601475679 5.43950830992156e-09 miRanda;miRNATAP -0.487175524672799 8.20248146886866e-11 NA NA NA hsa-miR-629-3p CXCL12 3.48282157979573 4.9176538695908e-08 -5.99088601475679 5.43950830992156e-09 MirTarget -0.428413927748216 2.27020696619312e-06 NA NA NA hsa-miR-96-5p CXCL12 5.62521466029286 1.54938806718028e-10 -5.99088601475679 5.43950830992156e-09 mirMAP -0.509688771282509 8.56150767049313e-11 NA NA NA hsa-miR-429 CYR61 6.39965293994036 1.96920201593608e-18 -3.64552653854158 4.2986658110635e-05 miRanda -0.284426559273065 1.35359304543889e-05 NA NA NA hsa-miR-106a-5p DAB2 3.98693608217557 9.37722470816656e-07 -2.2782007670164 0.000510161807747919 MirTarget;miRNATAP -0.336970848236555 7.46839262239177e-15 NA NA NA hsa-miR-106b-5p DAB2 2.80565545918114 1.14547999022566e-09 -2.2782007670164 0.000510161807747919 MirTarget;miRNATAP -0.373245322528672 2.13496676489413e-06 26769181 The expression of the miR-106b target gene DAB2 in human cervical tissues and cell lines were measured by qRT-PCR western blot and immunohistochemistry; DAB2 a predicted target gene of miR-106b was inhibited by TGF-β1 partly through miR-106b and was involved in TGF-β1-induced cervical cancer cell migration; The expression of DAB2 was low in cervical cancer tissues and negatively correlated with miR-106b expression cell migration cervical and endocervical cancer hsa-miR-17-5p DAB2 2.3269271449522 2.13987445663942e-05 -2.2782007670164 0.000510161807747919 MirTarget;TargetScan;miRNATAP -0.269063447961491 6.50132281614375e-05 NA NA NA hsa-miR-203a-3p DAB2 6.35084246337388 7.89944323347948e-08 -2.2782007670164 0.000510161807747919 MirTarget -0.107382451018428 0.000482068321126887 NA NA NA hsa-miR-20a-5p DAB2 2.13553469875764 0.000181201072324354 -2.2782007670164 0.000510161807747919 MirTarget;miRNATAP -0.230699920518281 0.000386678106270732 NA NA NA hsa-miR-20b-5p DAB2 4.5662923200279 4.75238200639144e-05 -2.2782007670164 0.000510161807747919 MirTarget;miRNATAP -0.202285532865137 2.64427494498865e-10 NA NA NA hsa-miR-339-5p DAB2 1.23326828594484 0.0307501214818698 -2.2782007670164 0.000510161807747919 miRanda -0.205234161251948 0.00175459671685983 NA NA NA hsa-miR-532-3p DAB2 0.643755490841218 0.214842585969913 -2.2782007670164 0.000510161807747919 PITA -0.21765715011877 0.00269147091922702 NA NA NA hsa-miR-93-5p DAB2 2.65964181833033 2.58315947526774e-08 -2.2782007670164 0.000510161807747919 MirTarget;miRNATAP -0.407091945067933 8.08478390826627e-08 24037530 miR 93 directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer; We next identify that microRNA miR-93 functions as a potent repressor of DAB2 expression by directly targeting the 3'UTR of the DAB2 mRNA; Using in vitro and in vivo approaches we demonstrate that miR-93 overexpression has an important role in promoting lung cancer cell growth and that its oncogenic function is primarily mediated by downregulating DAB2 expression; The correlations of both low DAB2 and high miR-93 expression levels with poor patient survival strongly support the critical role of the miR-93/DAB2 pathway in determining lung cancer progression progression;poor survival lung cancer hsa-miR-96-5p DAB2 5.62521466029286 1.54938806718028e-10 -2.2782007670164 0.000510161807747919 MirTarget;TargetScan -0.28482484281054 9.09528428460519e-09 NA NA NA hsa-let-7d-5p DCN 0.831142050231414 0.0126955498524287 -5.57812539480817 9.99722934741756e-08 MirTarget -0.693674106936328 0.000170980727532721 NA NA NA hsa-let-7g-5p DCN 0.857251702023746 0.00647597344297273 -5.57812539480817 9.99722934741756e-08 MirTarget -0.508204108340296 0.00996310545099632 NA NA NA hsa-miR-421 DCN 1.97624148591545 0.000915838012451138 -5.57812539480817 9.99722934741756e-08 miRanda -0.27580685200609 0.00668381401976743 NA NA NA hsa-miR-501-5p DCN 1.0411896821345 0.0777206709183552 -5.57812539480817 9.99722934741756e-08 mirMAP -0.35541924818636 0.000536225854622283 NA NA NA hsa-miR-590-3p DCN 2.35429565068338 2.79601879608564e-06 -5.57812539480817 9.99722934741756e-08 MirTarget;PITA;miRanda;mirMAP -0.417033846886242 0.000464733684797091 NA NA NA hsa-miR-7-1-3p DCN 1.43074343339835 0.00471215970502094 -5.57812539480817 9.99722934741756e-08 mirMAP -0.331009545534078 0.00582260375259807 NA NA NA hsa-let-7a-5p DPYSL3 0.148081801547773 0.645305441523746 -3.72728405358156 0.00122793411093784 TargetScan -0.645869144174417 0.00210294618763403 NA NA NA hsa-miR-141-3p DPYSL3 7.30474126597325 1.45115996357606e-24 -3.72728405358156 0.00122793411093784 TargetScan -0.37202686069007 1.01711336692137e-05 NA NA NA hsa-miR-141-5p DPYSL3 7.13744624551943 4.06877058732583e-26 -3.72728405358156 0.00122793411093784 MirTarget -0.398289425127284 7.05472664772032e-06 NA NA NA hsa-miR-29b-3p DPYSL3 0.666547117072858 0.234055379278093 -3.72728405358156 0.00122793411093784 MirTarget -0.509968936699144 1.31979640619898e-05 NA NA NA hsa-miR-31-3p DPYSL3 5.7035081317825 2.15133648211091e-05 -3.72728405358156 0.00122793411093784 MirTarget -0.177316067392678 0.00276193383879189 NA NA NA hsa-miR-330-3p DPYSL3 2.49094236945806 0.000129367003214715 -3.72728405358156 0.00122793411093784 MirTarget;PITA;miRNATAP -0.285406787917869 0.00456077251968549 NA NA NA hsa-miR-335-3p DPYSL3 1.19503568251824 0.0938852560631551 -3.72728405358156 0.00122793411093784 mirMAP -0.2816820032541 0.00224089125571357 NA NA NA hsa-miR-590-3p DPYSL3 2.35429565068338 2.79601879608564e-06 -3.72728405358156 0.00122793411093784 miRanda;mirMAP -0.402740507898548 0.00188762723768886 NA NA NA hsa-miR-616-5p DPYSL3 2.48416313933027 0.00318247475868827 -3.72728405358156 0.00122793411093784 mirMAP -0.284355284778356 0.0035358687572954 NA NA NA hsa-let-7g-5p DST 0.857251702023746 0.00647597344297273 -1.13168714065604 0.251054297059684 miRNATAP -0.468285360154056 0.00994146803888267 NA NA NA hsa-miR-106a-5p DST 3.98693608217557 9.37722470816656e-07 -1.13168714065604 0.251054297059684 mirMAP -0.292326179631657 1.22203916298656e-05 NA NA NA hsa-miR-130b-5p DST 3.74118449312296 2.92266550966038e-10 -1.13168714065604 0.251054297059684 mirMAP -0.344564139340885 0.000156086320337799 NA NA NA hsa-miR-186-5p DST 0.445443449112564 0.185447310527704 -1.13168714065604 0.251054297059684 mirMAP -0.679438348764452 5.70691174146187e-05 NA NA NA hsa-miR-192-5p DST 1.77716187978541 0.113485496183047 -1.13168714065604 0.251054297059684 miRNAWalker2_validate;mirMAP -0.283107193597763 5.45381761141022e-09 NA NA NA hsa-miR-200a-3p DST 6.336081120041 4.024313571871e-16 -1.13168714065604 0.251054297059684 mirMAP -0.318424842912785 2.27440240990563e-06 NA NA NA hsa-miR-200b-3p DST 5.56167217794639 6.43540045061709e-16 -1.13168714065604 0.251054297059684 mirMAP -0.398086894413212 1.65100329272265e-07 NA NA NA hsa-miR-20b-3p DST 3.32857825638616 0.0632388433748268 -1.13168714065604 0.251054297059684 mirMAP -0.258717396298741 1.96690208297502e-06 NA NA NA hsa-miR-20b-5p DST 4.5662923200279 4.75238200639144e-05 -1.13168714065604 0.251054297059684 mirMAP -0.242019106384505 5.57550386879745e-07 NA NA NA hsa-miR-215-5p DST 3.66990923176752 0.00294614570694381 -1.13168714065604 0.251054297059684 miRNAWalker2_validate -0.213397110208147 1.51318661719273e-06 NA NA NA hsa-miR-218-5p DST -1.62589026509455 0.0400573414088521 -1.13168714065604 0.251054297059684 miRNAWalker2_validate;mirMAP -0.194775778000982 0.00565210777080063 NA NA NA hsa-miR-26b-3p DST 0.985177548213122 0.0351427970185971 -1.13168714065604 0.251054297059684 mirMAP -0.3863595799156 0.00128914267139574 NA NA NA hsa-miR-3065-3p DST 1.89496019576082 0.0308154823923145 -1.13168714065604 0.251054297059684 mirMAP -0.370445564256537 2.32543596951507e-09 NA NA NA hsa-miR-362-5p DST -1.22309034685697 0.0452665543907975 -1.13168714065604 0.251054297059684 TargetScan;mirMAP -0.442701960548103 9.64357832388006e-07 NA NA NA hsa-miR-363-3p DST 4.27232887548977 8.53979362839458e-06 -1.13168714065604 0.251054297059684 mirMAP -0.256818520597825 6.04054850401066e-06 NA NA NA hsa-miR-378a-5p DST 1.25775140086104 0.0500877723587615 -1.13168714065604 0.251054297059684 MirTarget -0.291235751025148 0.000795828016313573 NA NA NA hsa-miR-378c DST 0.449601775771001 0.4993814483956 -1.13168714065604 0.251054297059684 mirMAP -0.274215101658898 0.00111268118790524 NA NA NA hsa-miR-429 DST 6.39965293994036 1.96920201593608e-18 -1.13168714065604 0.251054297059684 miRanda;mirMAP;miRNATAP -0.326049530068845 4.84616458026442e-06 NA NA NA hsa-miR-500a-3p DST 0.515751555939967 0.335082072556095 -1.13168714065604 0.251054297059684 mirMAP -0.416790085354464 6.52867650242795e-05 NA NA NA hsa-miR-508-3p DST 0.975099105064348 0.439528954969797 -1.13168714065604 0.251054297059684 mirMAP -0.22510687403841 3.16778427093962e-07 NA NA NA hsa-miR-532-3p DST 0.643755490841218 0.214842585969913 -1.13168714065604 0.251054297059684 mirMAP -0.553092888944143 2.170065364364e-07 NA NA NA hsa-miR-532-5p DST -0.297424983759107 0.503934707453099 -1.13168714065604 0.251054297059684 mirMAP -0.744929232144287 1.97887569273702e-09 NA NA NA hsa-miR-592 DST 2.80403350008555 0.0293520213681333 -1.13168714065604 0.251054297059684 mirMAP -0.23169379597924 1.08242724650967e-05 NA NA NA hsa-miR-92b-3p DST 1.69303761469782 0.0103484911955574 -1.13168714065604 0.251054297059684 mirMAP -0.249810224380262 0.00306401433966023 NA NA NA hsa-miR-326 ECM1 1.76645822596029 0.0367310428720192 0.526199250509763 0.646700061841886 miRanda -0.226895489597527 0.00328964977444473 NA NA NA hsa-miR-429 ECM1 6.39965293994036 1.96920201593608e-18 0.526199250509763 0.646700061841886 miRNATAP -0.26986316866582 0.00126283198732652 NA NA NA hsa-miR-125a-3p ECM2 -0.0748960586927341 0.920735897434087 -4.49012260690241 2.01273918565813e-08 miRanda -0.180171824467631 0.0035852845029644 NA NA NA hsa-miR-142-3p ECM2 4.35304505457969 3.10014573651358e-10 -4.49012260690241 2.01273918565813e-08 miRanda;miRNATAP -0.178575471963457 0.00618633658717121 NA NA NA hsa-miR-16-2-3p ECM2 3.79845098071094 1.49120139344659e-13 -4.49012260690241 2.01273918565813e-08 mirMAP -0.682815092216583 2.03109258997498e-16 NA NA NA hsa-miR-3065-5p ECM2 2.14185373842821 0.0609400502269891 -4.49012260690241 2.01273918565813e-08 mirMAP -0.175562832073576 0.000485905646097282 NA NA NA hsa-miR-30d-3p ECM2 -0.0740421896025512 0.857423650167556 -4.49012260690241 2.01273918565813e-08 MirTarget -0.436869811290233 0.000122350677971769 NA NA NA hsa-miR-320b ECM2 0.20205459771295 0.727216419960509 -4.49012260690241 2.01273918565813e-08 miRanda -0.209470456521016 0.00941734835029656 NA NA NA hsa-miR-331-5p ECM2 1.02712086964089 0.0262526092356277 -4.49012260690241 2.01273918565813e-08 MirTarget -0.46911000209877 2.73297649776419e-06 NA NA NA hsa-miR-335-3p ECM2 1.19503568251824 0.0938852560631551 -4.49012260690241 2.01273918565813e-08 MirTarget -0.212035194188317 0.00109507637831581 NA NA NA hsa-miR-452-3p ECM2 2.97956996345436 0.000203580834647624 -4.49012260690241 2.01273918565813e-08 MirTarget -0.224977515803716 8.21749890636352e-05 NA NA NA hsa-miR-590-3p ECM2 2.35429565068338 2.79601879608564e-06 -4.49012260690241 2.01273918565813e-08 MirTarget;miRanda;miRNATAP -0.369525645619918 4.81780237748269e-05 NA NA NA hsa-miR-590-5p ECM2 1.51400888103768 0.0023888567923017 -4.49012260690241 2.01273918565813e-08 miRanda -0.450190165072072 1.00963967130403e-06 NA NA NA hsa-miR-7-1-3p ECM2 1.43074343339835 0.00471215970502094 -4.49012260690241 2.01273918565813e-08 MirTarget -0.389209138271877 1.94646364572689e-05 NA NA NA hsa-let-7f-1-3p EDIL3 1.61507869803314 0.00069342464777815 -2.09127075060841 0.162787682764542 MirTarget -0.47785823891503 0.00778739942884821 NA NA NA hsa-miR-16-2-3p EDIL3 3.79845098071094 1.49120139344659e-13 -2.09127075060841 0.162787682764542 mirMAP -0.767698213984085 1.07065570225213e-06 NA NA NA hsa-miR-182-5p EDIL3 5.86988712704738 1.22411588571584e-15 -2.09127075060841 0.162787682764542 MirTarget -0.317394569548839 0.00398844716062287 NA NA NA hsa-miR-186-5p EDIL3 0.445443449112564 0.185447310527704 -2.09127075060841 0.162787682764542 mirMAP -0.682568579879037 0.00833076924433207 NA NA NA hsa-miR-32-3p EDIL3 2.20477794939766 0.0392771274032852 -2.09127075060841 0.162787682764542 mirMAP -0.477649542472793 0.000620600848079214 NA NA NA hsa-miR-335-3p EDIL3 1.19503568251824 0.0938852560631551 -2.09127075060841 0.162787682764542 MirTarget -0.311687865835231 0.00892700201325976 NA NA NA hsa-miR-501-5p EDIL3 1.0411896821345 0.0777206709183552 -2.09127075060841 0.162787682764542 mirMAP -0.442159444892852 0.00215914327317919 NA NA NA hsa-miR-590-3p EDIL3 2.35429565068338 2.79601879608564e-06 -2.09127075060841 0.162787682764542 miRanda;mirMAP -0.658455598347164 7.64596972349155e-05 NA NA NA hsa-miR-7-1-3p EDIL3 1.43074343339835 0.00471215970502094 -2.09127075060841 0.162787682764542 MirTarget -0.462937201425674 0.00591470584896409 NA NA NA hsa-miR-629-3p EFEMP2 3.48282157979573 4.9176538695908e-08 -3.85939549677142 6.33646434500553e-07 MirTarget -0.258988844826065 0.000148538080453282 NA NA NA hsa-miR-29b-3p ELN 0.666547117072858 0.234055379278093 -3.6169384801031 0.0108833474643081 MirTarget;miRNATAP -0.584456285345083 4.95686115459988e-05 NA NA NA hsa-miR-331-3p ELN 2.60769294751513 3.84318952029483e-07 -3.6169384801031 0.0108833474643081 MirTarget;PITA -0.743514663166771 1.2564906194599e-06 NA NA NA hsa-miR-3614-5p ELN 4.50236405439456 2.75644515847367e-07 -3.6169384801031 0.0108833474643081 mirMAP -0.631073218317797 5.95608702262522e-13 NA NA NA hsa-miR-421 ELN 1.97624148591545 0.000915838012451138 -3.6169384801031 0.0108833474643081 miRanda -0.447374373413687 0.000934018714828625 NA NA NA hsa-miR-30c-5p FAP 0.38723991118075 0.348605235643473 -3.31124819020579 0.00185436956740735 miRNATAP -0.563691429103958 0.000142370252435962 NA NA NA hsa-miR-30d-5p FAP 0.302504510257496 0.380193536606962 -3.31124819020579 0.00185436956740735 miRNATAP -0.8205395575081 4.10735963526479e-06 NA NA NA hsa-miR-375 FAP 3.3784490463318 0.0449946294355695 -3.31124819020579 0.00185436956740735 miRanda -0.121741564457625 0.000644748649005053 NA NA NA hsa-miR-429 FAP 6.39965293994036 1.96920201593608e-18 -3.31124819020579 0.00185436956740735 miRNATAP -0.506519187907488 2.72023271382671e-11 NA NA NA hsa-miR-106a-5p FAS 3.98693608217557 9.37722470816656e-07 -0.344841531633832 0.589341195024639 miRNAWalker2_validate;miRTarBase -0.140227807754695 0.00127753821199214 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-361-5p FAS 0.00649167180664723 0.985202350239079 -0.344841531633832 0.589341195024639 miRanda -0.330419186265804 0.00171930259182594 NA NA NA hsa-miR-590-5p FAS 1.51400888103768 0.0023888567923017 -0.344841531633832 0.589341195024639 miRanda -0.19807034795777 0.00636164081342142 NA NA NA hsa-miR-107 FBLN1 1.49443409571439 0.000130594521065411 -2.2742994764151 0.00137049282796207 miRanda -0.276759110358953 0.00797347445019381 NA NA NA hsa-miR-24-3p FBLN1 1.55853749533999 0.000524726461381821 -2.2742994764151 0.00137049282796207 MirTarget -0.422886740080659 2.17417070038494e-06 NA NA NA hsa-miR-330-5p FBLN1 2.25110496739954 0.000275527655397415 -2.2742994764151 0.00137049282796207 miRanda -0.191113744631192 0.00328602205527504 NA NA NA hsa-miR-421 FBLN1 1.97624148591545 0.000915838012451138 -2.2742994764151 0.00137049282796207 miRanda -0.197780793177074 0.00357743068718701 NA NA NA hsa-miR-128-3p FBLN2 1.36248409467631 0.00408435995818078 -1.83654759421009 0.0361428107758621 MirTarget -0.332951364171489 0.00153171065562492 NA NA NA hsa-miR-200c-3p FBLN5 6.47012025883743 2.64500707716408e-26 -4.86226771245185 1.33095462605993e-09 miRNAWalker2_validate;miRTarBase -0.415830464291299 1.53051300969547e-09 NA NA NA hsa-miR-330-3p FBLN5 2.49094236945806 0.000129367003214715 -4.86226771245185 1.33095462605993e-09 miRNATAP -0.225294732767008 0.00158105549228319 NA NA NA hsa-miR-429 FBLN5 6.39965293994036 1.96920201593608e-18 -4.86226771245185 1.33095462605993e-09 miRanda;miRNATAP -0.28336086877123 1.97445633852014e-06 NA NA NA hsa-let-7f-1-3p FBN1 1.61507869803314 0.00069342464777815 -3.0336612039306 0.00133345999547796 mirMAP -0.457521787614346 5.28387548326838e-05 NA NA NA hsa-miR-16-2-3p FBN1 3.79845098071094 1.49120139344659e-13 -3.0336612039306 0.00133345999547796 mirMAP -0.688355653432857 2.05167849789768e-12 NA NA NA hsa-miR-182-5p FBN1 5.86988712704738 1.22411588571584e-15 -3.0336612039306 0.00133345999547796 miRNATAP -0.260650064759732 0.000183535762264279 NA NA NA hsa-miR-188-5p FBN1 1.39111178824125 0.0251592818948912 -3.0336612039306 0.00133345999547796 PITA -0.255395939127434 0.00341142691139413 NA NA NA hsa-miR-192-5p FBN1 1.77716187978541 0.113485496183047 -3.0336612039306 0.00133345999547796 miRNAWalker2_validate -0.152067369012184 0.00146321360115045 NA NA NA hsa-miR-19b-1-5p FBN1 1.51335451095424 0.0014717605268143 -3.0336612039306 0.00133345999547796 mirMAP -0.657795480907075 3.22830130386598e-09 NA NA NA hsa-miR-215-5p FBN1 3.66990923176752 0.00294614570694381 -3.0336612039306 0.00133345999547796 miRNAWalker2_validate -0.145031953679705 0.0008025453078808 NA NA NA hsa-miR-25-3p FBN1 1.12623030168869 0.00311079344417173 -3.0336612039306 0.00133345999547796 mirMAP -0.593729233805618 2.93331980023833e-05 NA NA NA hsa-miR-3065-5p FBN1 2.14185373842821 0.0609400502269891 -3.0336612039306 0.00133345999547796 mirMAP -0.203273882729632 0.000508841418354962 NA NA NA hsa-miR-32-3p FBN1 2.20477794939766 0.0392771274032852 -3.0336612039306 0.00133345999547796 miRNATAP -0.297767083310933 0.00078289104898888 NA NA NA hsa-miR-362-3p FBN1 0.679952485897744 0.226148468488576 -3.0336612039306 0.00133345999547796 miRanda;miRNATAP -0.36332482306036 0.000162137351159021 NA NA NA hsa-miR-363-3p FBN1 4.27232887548977 8.53979362839458e-06 -3.0336612039306 0.00133345999547796 mirMAP -0.269064734484972 8.50889616317298e-07 NA NA NA hsa-miR-429 FBN1 6.39965293994036 1.96920201593608e-18 -3.0336612039306 0.00133345999547796 miRNATAP -0.442180661911882 6.49767551824412e-11 NA NA NA hsa-miR-576-5p FBN1 1.30320223793746 0.00648929463912994 -3.0336612039306 0.00133345999547796 mirMAP -0.402207073847227 0.000357730136633156 NA NA NA hsa-miR-590-3p FBN1 2.35429565068338 2.79601879608564e-06 -3.0336612039306 0.00133345999547796 miRanda;mirMAP -0.31603024450708 0.00294818201409146 NA NA NA hsa-miR-92a-3p FBN1 1.87892405805529 1.27013821556583e-05 -3.0336612039306 0.00133345999547796 mirMAP -0.557192310569391 6.77216541256814e-06 NA NA NA hsa-miR-92b-3p FBN1 1.69303761469782 0.0103484911955574 -3.0336612039306 0.00133345999547796 mirMAP -0.263697749666319 0.00119119241674081 NA NA NA hsa-miR-101-3p FBN2 -1.12421603598195 0.0200907284788457 -0.774064139591112 0.647583378527672 miRNAWalker2_validate;MirTarget;miRNATAP -0.596013602712406 0.0027656046000357 NA NA NA hsa-miR-146b-5p FERMT2 1.87569569182453 0.000737241069698886 -4.36546024261243 6.75771952930767e-07 miRanda -0.2730413070683 0.00267086817066861 NA NA NA hsa-miR-15a-5p FERMT2 2.0535411006904 1.91108976398046e-06 -4.36546024261243 6.75771952930767e-07 MirTarget;miRNATAP -0.469420901927593 5.34868417689169e-05 NA NA NA hsa-miR-16-5p FERMT2 2.93575808220754 2.15436817162977e-10 -4.36546024261243 6.75771952930767e-07 MirTarget;miRNATAP -0.539404897020064 3.39742226344188e-07 NA NA NA hsa-miR-200b-3p FERMT2 5.56167217794639 6.43540045061709e-16 -4.36546024261243 6.75771952930767e-07 TargetScan -0.308621624004216 8.90176865874781e-06 23483548;24064224;26334393 Here we report that Kindlin 2 markedly downregulates the expression of miR-200 family by inducing CpG island hypermethylation; Our data indicate that Kindlin 2 plays a novel role in epigenetic repression of miR-200 family a mechanism that promotes breast cancer invasion;miR 200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin 2; Quantitative mass spectrometry identified 57 putative miR-200b targets including Kindlin-2 previously implicated in the regulation of tumor invasiveness and actin cytoskeleton in other cell types; Enforced expression of miR-200b mimic in ESCC cells led to a decrease of Kindlin-2 expression whereas transfection of miR-200b inhibitor induced Kindlin-2 expression; Furthermore transfection of miR-200b mimic or knockdown of Kindlin-2 in ESCC cells decreased cell protrusion and focal adhesion FA formation reduced cell spreading and invasiveness/migration; Enforced expression of Kindlin-2 largely abrogated the inhibitory effects of miR-200b on ESCC cell invasiveness; The tumor suppressor effects of miR-200b may be due to its suppression of Kindlin-2 a novel target of miR-200b that modulates actin cytoskeleton FA formation and the migratory/invasiveness properties of ESCC;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ;; breast cancer;esophageal cancer;esophageal cancer hsa-miR-205-5p FERMT2 8.08298115900323 3.83045179398654e-07 -4.36546024261243 6.75771952930767e-07 miRNATAP -0.190062882324591 3.77844042249662e-10 NA NA NA hsa-miR-21-5p FERMT2 2.65163477806992 6.72089787690756e-16 -4.36546024261243 6.75771952930767e-07 miRNAWalker2_validate -0.575916293604471 0.000114981217480358 NA NA NA hsa-miR-221-3p FERMT2 0.94082283577318 0.174749164179978 -4.36546024261243 6.75771952930767e-07 MirTarget;miRNATAP -0.51826536950492 2.09677014399525e-13 NA NA NA hsa-miR-222-3p FERMT2 1.54730827524553 0.0223014220569407 -4.36546024261243 6.75771952930767e-07 MirTarget;miRNATAP -0.529566460367896 2.04645862729756e-13 NA NA NA hsa-miR-29b-3p FERMT2 0.666547117072858 0.234055379278093 -4.36546024261243 6.75771952930767e-07 MirTarget;miRNATAP -0.378395653304076 2.77813177550973e-05 NA NA NA hsa-miR-29c-3p FERMT2 -0.414153610337085 0.529344128062017 -4.36546024261243 6.75771952930767e-07 MirTarget;miRNATAP -0.373525555947418 9.68148367077043e-07 NA NA NA hsa-miR-429 FERMT2 6.39965293994036 1.96920201593608e-18 -4.36546024261243 6.75771952930767e-07 miRanda;miRNATAP -0.255667124730402 8.47422028383377e-05 NA NA NA hsa-miR-590-3p FERMT2 2.35429565068338 2.79601879608564e-06 -4.36546024261243 6.75771952930767e-07 MirTarget;miRanda;mirMAP;miRNATAP -0.400610281078161 5.50148001979779e-05 NA NA NA hsa-miR-15a-5p FGF2 2.0535411006904 1.91108976398046e-06 -4.7426237294682 2.88390048531716e-06 MirTarget;miRNATAP -0.544091858031343 4.73995293778273e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 2.83281226969693 7.54359864580834e-09 -4.7426237294682 2.88390048531716e-06 mirMAP -0.519661346969457 7.25223541348293e-06 NA NA NA hsa-miR-16-2-3p FGF2 3.79845098071094 1.49120139344659e-13 -4.7426237294682 2.88390048531716e-06 mirMAP -0.459075147077176 2.39530412317278e-05 NA NA NA hsa-miR-16-5p FGF2 2.93575808220754 2.15436817162977e-10 -4.7426237294682 2.88390048531716e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.382491794884229 0.00193553698923076 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-19b-1-5p FGF2 1.51335451095424 0.0014717605268143 -4.7426237294682 2.88390048531716e-06 mirMAP -0.48434219021616 7.33107402348553e-05 NA NA NA hsa-miR-200b-3p FGF2 5.56167217794639 6.43540045061709e-16 -4.7426237294682 2.88390048531716e-06 mirMAP -0.509650803431375 8.73024781893149e-11 NA NA NA hsa-miR-200c-3p FGF2 6.47012025883743 2.64500707716408e-26 -4.7426237294682 2.88390048531716e-06 mirMAP -0.509145367686688 3.3797939749436e-09 NA NA NA hsa-miR-21-5p FGF2 2.65163477806992 6.72089787690756e-16 -4.7426237294682 2.88390048531716e-06 mirMAP -0.567342076857507 0.00100450723749317 NA NA NA hsa-miR-429 FGF2 6.39965293994036 1.96920201593608e-18 -4.7426237294682 2.88390048531716e-06 mirMAP -0.436553293587648 3.16850635903379e-09 NA NA NA hsa-miR-200c-3p FLNA 6.47012025883743 2.64500707716408e-26 -2.74909594751263 1.93215705156445e-05 miRNAWalker2_validate -0.288078196729452 1.44623491387617e-07 NA NA NA hsa-miR-185-3p FMOD 2.44625550129147 0.000878038743901412 -4.02539650946723 9.51230967918598e-06 MirTarget -0.258103174173849 0.00288402961403232 NA NA NA hsa-miR-21-5p FMOD 2.65163477806992 6.72089787690756e-16 -4.02539650946723 9.51230967918598e-06 miRNAWalker2_validate;miRTarBase -0.587701206119074 0.000134387089916172 19906824;23445447 Gain-of miR-21 function in MSMC and LSMC reduced TGF-beta-induced expression of fibromodulin and TGF-beta-induced factor P < 0.05 and moderately altered the rate of cell growth and caspase-3/7 activity in these cells;Our method exhibits ultrahigh sensitivity toward miR-21 with detection limits of 10 fM at 37 °C and 1 aM at 4 °C which corresponds to nine strands of miR-21 in a 15 μL sample and it is capable of distinguishing among miRNA family members ; sarcoma;breast cancer hsa-miR-330-5p FMOD 2.25110496739954 0.000275527655397415 -4.02539650946723 9.51230967918598e-06 miRanda -0.402951723780213 1.14902121869496e-06 NA NA NA hsa-miR-590-5p FMOD 1.51400888103768 0.0023888567923017 -4.02539650946723 9.51230967918598e-06 miRanda -0.447022100809738 1.74752826053815e-05 NA NA NA hsa-let-7g-5p FN1 0.857251702023746 0.00647597344297273 -1.36144636221369 0.250505962748653 miRTarBase -0.903563051022715 2.98249474336263e-05 NA NA NA hsa-miR-16-1-3p FN1 2.83281226969693 7.54359864580834e-09 -1.36144636221369 0.250505962748653 mirMAP -0.453331376891726 0.000725705336567709 NA NA NA hsa-miR-200b-3p FN1 5.56167217794639 6.43540045061709e-16 -1.36144636221369 0.250505962748653 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.638482901225541 1.10651140093297e-12 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-200c-3p FN1 6.47012025883743 2.64500707716408e-26 -1.36144636221369 0.250505962748653 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.527098065662119 1.20069978407088e-07 NA NA NA hsa-miR-33a-3p FN1 2.06269680799532 0.00156436055383943 -1.36144636221369 0.250505962748653 mirMAP -0.317910914603669 0.00198782552519901 NA NA NA hsa-miR-429 FN1 6.39965293994036 1.96920201593608e-18 -1.36144636221369 0.250505962748653 MirTarget;PITA;miRanda;miRNATAP -0.489245625265544 8.21510685952814e-09 NA NA NA hsa-miR-96-5p FN1 5.62521466029286 1.54938806718028e-10 -1.36144636221369 0.250505962748653 MirTarget;TargetScan -0.234847002718398 0.00970463192782325 NA NA NA hsa-miR-142-5p FSTL1 3.95552531913424 1.49536283724079e-08 -2.21286155841259 0.0039580105672751 PITA;mirMAP -0.202356099776746 0.000910453449516431 NA NA NA hsa-miR-155-5p FSTL1 2.81443182173772 7.42530504828797e-05 -2.21286155841259 0.0039580105672751 miRNAWalker2_validate -0.220041928181102 0.000287182963022418 NA NA NA hsa-miR-200b-3p FSTL1 5.56167217794639 6.43540045061709e-16 -2.21286155841259 0.0039580105672751 MirTarget;TargetScan -0.277740306176819 3.4352837450652e-06 NA NA NA hsa-miR-200c-3p FSTL1 6.47012025883743 2.64500707716408e-26 -2.21286155841259 0.0039580105672751 MirTarget -0.236502542187358 0.000315797242807464 NA NA NA hsa-miR-203a-3p FSTL1 6.35084246337388 7.89944323347948e-08 -2.21286155841259 0.0039580105672751 MirTarget -0.237462544589958 1.13397272896426e-11 NA NA NA hsa-miR-24-1-5p FSTL1 -0.638925193416348 0.236125310537158 -2.21286155841259 0.0039580105672751 MirTarget -0.231044164397312 0.00461371869651434 NA NA NA hsa-miR-27b-5p FSTL1 0.213392605793392 0.71562473353293 -2.21286155841259 0.0039580105672751 mirMAP -0.359200259195413 1.25482444436062e-06 NA NA NA hsa-miR-362-5p FSTL1 -1.22309034685697 0.0452665543907975 -2.21286155841259 0.0039580105672751 mirMAP -0.222231307692466 0.00190526285310301 NA NA NA hsa-miR-429 FSTL1 6.39965293994036 1.96920201593608e-18 -2.21286155841259 0.0039580105672751 MirTarget;PITA;miRanda -0.20525614102089 0.000258993808967469 NA NA NA hsa-miR-452-5p FSTL1 2.45466810475361 0.00114794259949532 -2.21286155841259 0.0039580105672751 mirMAP -0.176903799374869 0.00207675663925325 NA NA NA hsa-miR-9-5p FSTL1 1.79620806707734 0.14526963042518 -2.21286155841259 0.0039580105672751 MirTarget -0.128096480208926 0.000271284134654885 NA NA NA hsa-miR-944 FSTL1 7.20925181386398 0.000823207457340648 -2.21286155841259 0.0039580105672751 mirMAP -0.122461841099565 6.83295718294479e-07 NA NA NA hsa-miR-362-3p FSTL3 0.679952485897744 0.226148468488576 -1.35407751911015 0.141492357712278 MirTarget;miRanda -0.358345122813992 0.000120066199857081 NA NA NA hsa-miR-375 FSTL3 3.3784490463318 0.0449946294355695 -1.35407751911015 0.141492357712278 miRNAWalker2_validate -0.121506755003397 7.13560102085581e-05 NA NA NA hsa-miR-590-3p FZD8 2.35429565068338 2.79601879608564e-06 -0.605760786756907 0.557609369330486 miRanda -0.346881927689195 0.00260365350935014 NA NA NA hsa-miR-129-5p GADD45A -2.66843722411409 0.00695783358331245 -0.566112082294352 0.356860494529648 miRanda -0.100844116127556 0.00449173907374446 NA NA NA hsa-miR-130b-3p GADD45A 3.9204771543282 1.2714917955808e-11 -0.566112082294352 0.356860494529648 MirTarget;miRNATAP -0.171179592036229 0.0032386084520536 NA NA NA hsa-miR-146b-5p GADD45A 1.87569569182453 0.000737241069698886 -0.566112082294352 0.356860494529648 miRanda -0.18967214107464 0.00232775278051048 NA NA NA hsa-miR-148b-3p GADD45A 1.75622244535669 8.84414356040579e-08 -0.566112082294352 0.356860494529648 MirTarget -0.525743475009119 5.01282872316168e-07 NA NA NA hsa-miR-301a-3p GADD45A 1.99338115332667 0.000813358604963724 -0.566112082294352 0.356860494529648 MirTarget;miRNATAP -0.190939096191683 0.000994881284680524 NA NA NA hsa-miR-362-5p GADD45A -1.22309034685697 0.0452665543907975 -0.566112082294352 0.356860494529648 MirTarget;PITA;miRNATAP -0.174083394504546 0.00221778809043954 NA NA NA hsa-miR-375 GADD45A 3.3784490463318 0.0449946294355695 -0.566112082294352 0.356860494529648 miRanda -0.102232241980599 4.20822114251968e-07 NA NA NA hsa-miR-454-3p GADD45A 1.40269869979902 0.00366085847011367 -0.566112082294352 0.356860494529648 MirTarget;miRNATAP -0.309147097462117 1.56973939454024e-05 NA NA NA hsa-miR-500a-5p GADD45A 0.0170829425378565 0.973960207660626 -0.566112082294352 0.356860494529648 MirTarget;miRNATAP -0.191557624174549 0.00426069074325481 NA NA NA hsa-miR-500b-5p GADD45A 0.0167434146432646 0.974498641907253 -0.566112082294352 0.356860494529648 MirTarget -0.191191795665263 0.0043023159901196 NA NA NA hsa-miR-324-3p GADD45B 1.51345381556672 0.0038447546677657 -1.882739402569 0.00168698437811886 MirTarget;miRNATAP -0.17112830558095 0.00882982096915685 NA NA NA hsa-miR-130b-3p GAS1 3.9204771543282 1.2714917955808e-11 -3.97561799731662 0.000437046185588397 miRNAWalker2_validate -0.322887547822672 0.00281712102199038 NA NA NA hsa-miR-183-5p GAS1 6.61903249270777 1.00958881445636e-16 -3.97561799731662 0.000437046185588397 miRNAWalker2_validate -0.282137222076632 0.000225423791333407 NA NA NA hsa-miR-33a-5p GAS1 2.60046838991599 0.000472459723448608 -3.97561799731662 0.000437046185588397 miRNATAP -0.253510351484688 0.00324699103604844 NA NA NA hsa-miR-33b-5p GAS1 4.77891217497671 1.33695107675057e-08 -3.97561799731662 0.000437046185588397 miRNATAP -0.199491422773454 0.00807963505116949 NA NA NA hsa-miR-34a-5p GAS1 0.830377770217786 0.0477544831885907 -3.97561799731662 0.000437046185588397 miRNAWalker2_validate;miRNATAP -0.656789825715087 2.13062490608594e-05 24220341 MiR 34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway; Both miR-34a and GAS1 are frequently down-regulated in various tumors; However it has been reported that while GAS1 is down-regulated in papillary thyroid carcinoma PTC miR-34a is up-regulated in this specific type of cancer although their potential roles in PTC tumorigenesis have not been examined to date; A computational search revealed that miR-34a putatively binds to the 3'-UTR of GAS1 gene; In the present study we confirmed previous findings that miR-34a is up-regulated and GAS1 down-regulated in PTC tissues; Further studies indicated that GAS1 is directly targeted by miR-34a; Silencing of GAS1 had similar growth-promoting effects as overexpression of miR-34a; Taken together our results demonstrate that miR-34a regulates GAS1 expression to promote proliferation and suppress apoptosis in PTC cells via PI3K/Akt/Bad pathway tumorigenesis thyroid cancer hsa-miR-3607-3p GAS1 1.38015131722213 0.0240067155694847 -3.97561799731662 0.000437046185588397 MirTarget -0.30249226852527 0.0042162717756735 NA NA NA hsa-miR-141-3p GEM 7.30474126597325 1.45115996357606e-24 -3.67606699359352 4.72058151247075e-06 MirTarget -0.344786991822023 3.67142564103743e-09 NA NA NA hsa-miR-200a-3p GEM 6.336081120041 4.024313571871e-16 -3.67606699359352 4.72058151247075e-06 MirTarget -0.195426994077563 0.000505322340381016 NA NA NA hsa-miR-200b-3p GEM 5.56167217794639 6.43540045061709e-16 -3.67606699359352 4.72058151247075e-06 MirTarget -0.179934801144683 0.00487280913649338 NA NA NA hsa-miR-200c-3p GEM 6.47012025883743 2.64500707716408e-26 -3.67606699359352 4.72058151247075e-06 MirTarget;miRNATAP -0.330688787908482 1.5445873565411e-06 NA NA NA hsa-miR-429 GEM 6.39965293994036 1.96920201593608e-18 -3.67606699359352 4.72058151247075e-06 MirTarget;PITA;miRanda;miRNATAP -0.187401726896159 0.00164563122608984 NA NA NA hsa-miR-590-3p GEM 2.35429565068338 2.79601879608564e-06 -3.67606699359352 4.72058151247075e-06 miRanda -0.303836515136688 0.000828033742567298 NA NA NA hsa-miR-142-3p GJA1 4.35304505457969 3.10014573651358e-10 -1.39426744876439 0.17815205127817 miRanda -0.212874588571717 0.00987424972510244 NA NA NA hsa-miR-148b-5p GJA1 2.80812018666078 3.97536665756679e-08 -1.39426744876439 0.17815205127817 MirTarget -0.30569818767092 0.00690531903343321 NA NA NA hsa-miR-30d-3p GJA1 -0.0740421896025512 0.857423650167556 -1.39426744876439 0.17815205127817 MirTarget -0.444012598759069 0.00210128159935933 NA NA NA hsa-miR-30d-5p GJA1 0.302504510257496 0.380193536606962 -1.39426744876439 0.17815205127817 MirTarget;mirMAP;miRNATAP -0.578311229165012 0.000871621770554707 NA NA NA hsa-miR-429 GJA1 6.39965293994036 1.96920201593608e-18 -1.39426744876439 0.17815205127817 miRanda;miRNATAP -0.207727512276151 0.00610758158875942 NA NA NA hsa-miR-582-5p GJA1 0.685177900016753 0.447761540297692 -1.39426744876439 0.17815205127817 miRNATAP -0.225690354432777 0.00049271110588799 NA NA NA hsa-miR-616-5p GJA1 2.48416313933027 0.00318247475868827 -1.39426744876439 0.17815205127817 MirTarget;mirMAP -0.338096850805243 9.18788185055734e-05 NA NA NA hsa-miR-7-1-3p GJA1 1.43074343339835 0.00471215970502094 -1.39426744876439 0.17815205127817 mirMAP -0.34577411570612 0.00289032368936361 NA NA NA hsa-miR-148b-5p GLIPR1 2.80812018666078 3.97536665756679e-08 -2.20385308644488 0.00112945505784521 mirMAP -0.236640363165139 0.00143911916838042 NA NA NA hsa-miR-16-2-3p GLIPR1 3.79845098071094 1.49120139344659e-13 -2.20385308644488 0.00112945505784521 mirMAP -0.292368876866942 4.80643509667035e-05 NA NA NA hsa-miR-19b-3p GLIPR1 1.67581705793313 0.000858910586302716 -2.20385308644488 0.00112945505784521 mirMAP -0.278901774793644 0.000262121754400762 NA NA NA hsa-miR-20a-3p GLIPR1 1.9920766549842 0.000624458530894697 -2.20385308644488 0.00112945505784521 mirMAP -0.177963476917991 0.00705305754146029 NA NA NA hsa-miR-26b-3p GLIPR1 0.985177548213122 0.0351427970185971 -2.20385308644488 0.00112945505784521 mirMAP -0.268828402675603 0.00119256593846939 NA NA NA hsa-miR-30d-3p GLIPR1 -0.0740421896025512 0.857423650167556 -2.20385308644488 0.00112945505784521 mirMAP -0.366836728681571 0.000104118191410215 NA NA NA hsa-miR-9-5p GLIPR1 1.79620806707734 0.14526963042518 -2.20385308644488 0.00112945505784521 mirMAP -0.126005727565134 4.7272051368241e-05 NA NA NA hsa-miR-942-5p GLIPR1 3.36242661558642 1.89848306955335e-10 -2.20385308644488 0.00112945505784521 MirTarget -0.242302927974435 0.000652051659888939 NA NA NA hsa-miR-194-3p GPC1 1.91743783341496 0.105383373371284 1.45307243044546 0.0388204556582202 mirMAP -0.274157972554644 1.6896603876781e-17 NA NA NA hsa-miR-3200-3p GPC1 2.3251191657063 0.0140310042534957 1.45307243044546 0.0388204556582202 mirMAP -0.139296945181156 0.000977862387922997 NA NA NA hsa-miR-29b-3p GPX7 0.666547117072858 0.234055379278093 -1.10959821997502 0.15816901358764 MirTarget;miRNATAP -0.265531480857564 0.000866780756033364 NA NA NA hsa-miR-107 GREM1 1.49443409571439 0.000130594521065411 -1.90177748877488 0.0936801310258417 miRanda -0.656966478576047 6.50310011186258e-05 NA NA NA hsa-miR-128-3p GREM1 1.36248409467631 0.00408435995818078 -1.90177748877488 0.0936801310258417 MirTarget -0.483675209802739 0.00036078902543268 NA NA NA hsa-miR-15b-3p GREM1 3.57530146629867 5.89922785773482e-11 -1.90177748877488 0.0936801310258417 mirMAP -0.419947632860335 0.000232077273547984 NA NA NA hsa-miR-186-5p GREM1 0.445443449112564 0.185447310527704 -1.90177748877488 0.0936801310258417 mirMAP -0.573162463120074 0.00340767611046378 NA NA NA hsa-miR-200b-3p GREM1 5.56167217794639 6.43540045061709e-16 -1.90177748877488 0.0936801310258417 MirTarget -0.394723101630866 7.52743404397398e-06 NA NA NA hsa-miR-200c-3p GREM1 6.47012025883743 2.64500707716408e-26 -1.90177748877488 0.0936801310258417 MirTarget -0.405948813795272 2.47036834650093e-05 NA NA NA hsa-miR-30d-3p GREM1 -0.0740421896025512 0.857423650167556 -1.90177748877488 0.0936801310258417 MirTarget -0.637583493920579 5.12299743608953e-05 NA NA NA hsa-miR-32-3p GREM1 2.20477794939766 0.0392771274032852 -1.90177748877488 0.0936801310258417 mirMAP -0.435686729069973 3.48844599868718e-05 NA NA NA hsa-miR-362-3p GREM1 0.679952485897744 0.226148468488576 -1.90177748877488 0.0936801310258417 miRanda -0.419392352136761 0.000265669629576036 NA NA NA hsa-miR-429 GREM1 6.39965293994036 1.96920201593608e-18 -1.90177748877488 0.0936801310258417 MirTarget;miRanda -0.366128719768853 8.54323526406968e-06 NA NA NA hsa-miR-484 GREM1 1.79050445056016 0.000217287101253701 -1.90177748877488 0.0936801310258417 PITA -0.410131918108546 0.00197300195824649 NA NA NA hsa-miR-576-5p GREM1 1.30320223793746 0.00648929463912994 -1.90177748877488 0.0936801310258417 mirMAP -0.411373832585799 0.00227560696068622 NA NA NA hsa-miR-616-5p GREM1 2.48416313933027 0.00318247475868827 -1.90177748877488 0.0936801310258417 mirMAP -0.346833690936658 0.000259309886985072 NA NA NA hsa-miR-16-5p HTRA1 2.93575808220754 2.15436817162977e-10 -2.52247588590451 0.000137400346870378 miRNAWalker2_validate -0.286269467771414 0.000332732748779796 NA NA NA hsa-let-7a-3p ID2 0.82512001802525 0.0468122405194487 -1.44903761787758 0.028108297351186 miRNATAP -0.332304595270933 0.000255934152081128 NA NA NA hsa-miR-139-5p ID2 -2.09475477693654 0.000382570602748311 -1.44903761787758 0.028108297351186 miRanda -0.170162907716332 0.00711830840129372 NA NA NA hsa-miR-27a-3p ID2 1.76094007417453 0.000216137556256765 -1.44903761787758 0.028108297351186 MirTarget;miRNATAP -0.360335443916806 3.57937005002133e-06 NA NA NA hsa-miR-330-3p ID2 2.49094236945806 0.000129367003214715 -1.44903761787758 0.028108297351186 MirTarget;PITA;miRNATAP -0.211998117870452 0.000199415670908787 NA NA NA hsa-miR-335-3p ID2 1.19503568251824 0.0938852560631551 -1.44903761787758 0.028108297351186 MirTarget -0.185872652315649 0.000380455687029298 NA NA NA hsa-miR-455-3p ID2 2.1864857056272 0.00137304627957677 -1.44903761787758 0.028108297351186 MirTarget;PITA;miRNATAP -0.159086590304116 0.003512126153271 NA NA NA hsa-miR-193a-3p IGFBP2 0.646392169474854 0.207134343676122 -0.49205667933822 0.689979849775125 miRanda -0.606568791293117 8.07708329654438e-06 NA NA NA hsa-miR-330-5p IGFBP2 2.25110496739954 0.000275527655397415 -0.49205667933822 0.689979849775125 miRanda -0.429915576571385 0.000115210070341998 NA NA NA hsa-miR-19a-3p IGFBP3 2.17020503944519 0.00122084653711062 -2.12921819775598 0.0327776531676316 MirTarget;miRNATAP -0.283452750836352 0.000710551715277028 NA NA NA hsa-miR-19b-3p IGFBP3 1.67581705793313 0.000858910586302716 -2.12921819775598 0.0327776531676316 MirTarget;miRNATAP -0.343779035868688 0.00224468336201034 NA NA NA hsa-miR-340-5p IGFBP3 1.41210478721579 0.00958612942879818 -2.12921819775598 0.0327776531676316 MirTarget -0.403426206170816 9.88624132059415e-05 NA NA NA hsa-miR-532-3p IGFBP4 0.643755490841218 0.214842585969913 -2.8772176221471 1.31369505470256e-05 miRNATAP -0.194064997954641 0.00835583822338067 NA NA NA hsa-miR-129-5p IL15 -2.66843722411409 0.00695783358331245 0.465169356458177 0.598108692321668 miRanda -0.278427011009127 2.67964756543556e-08 NA NA NA hsa-miR-130b-3p IL15 3.9204771543282 1.2714917955808e-11 0.465169356458177 0.598108692321668 MirTarget -0.474391480902627 6.90220060227263e-09 NA NA NA hsa-miR-301a-3p IL15 1.99338115332667 0.000813358604963724 0.465169356458177 0.598108692321668 MirTarget -0.258250382098669 0.00196518341564906 NA NA NA hsa-miR-324-5p IL15 1.31253452379847 0.0116806680545163 0.465169356458177 0.598108692321668 miRanda -0.326276713254996 0.000669600602729267 NA NA NA hsa-miR-421 IL15 1.97624148591545 0.000915838012451138 0.465169356458177 0.598108692321668 miRanda -0.277368606921639 0.000895477513886754 NA NA NA hsa-miR-429 IL15 6.39965293994036 1.96920201593608e-18 0.465169356458177 0.598108692321668 miRanda -0.252665934473771 7.98172749078667e-05 NA NA NA hsa-miR-493-5p IL15 0.170487141312394 0.834200945899452 0.465169356458177 0.598108692321668 MirTarget -0.20873400857523 0.000658566188988613 NA NA NA hsa-miR-429 IL6 6.39965293994036 1.96920201593608e-18 -0.812372330269044 0.556990548550307 miRanda -0.497764450854261 5.94299314121074e-07 NA NA NA hsa-miR-10a-3p INHBA 0.970411431936568 0.31667483998251 0.597174749350624 0.643310167999085 mirMAP -0.228868949828328 0.00288571997624358 NA NA NA hsa-miR-10b-5p INHBA -3.08172917642729 4.22675074435126e-09 0.597174749350624 0.643310167999085 miRNAWalker2_validate -0.375135520462904 0.00596419514318865 NA NA NA hsa-miR-148b-3p INHBA 1.75622244535669 8.84414356040579e-08 0.597174749350624 0.643310167999085 miRNAWalker2_validate -0.667439513931159 0.00272176813701307 NA NA NA hsa-miR-16-2-3p INHBA 3.79845098071094 1.49120139344659e-13 0.597174749350624 0.643310167999085 mirMAP -0.460254491787022 0.000754313391824958 NA NA NA hsa-miR-195-3p INHBA -2.39100534119332 0.000185405399054065 0.597174749350624 0.643310167999085 mirMAP -0.359920153494247 0.00156804274458257 NA NA NA hsa-miR-200b-3p INHBA 5.56167217794639 6.43540045061709e-16 0.597174749350624 0.643310167999085 TargetScan -0.556231875088492 1.97398662453022e-08 NA NA NA hsa-miR-3065-5p INHBA 2.14185373842821 0.0609400502269891 0.597174749350624 0.643310167999085 mirMAP -0.362079017770634 4.04665334650244e-06 NA NA NA hsa-miR-30b-5p INHBA 0.0238659735605804 0.953223658270319 0.597174749350624 0.643310167999085 mirMAP -0.641790503573834 0.00040859319409002 NA NA NA hsa-miR-30c-5p INHBA 0.38723991118075 0.348605235643473 0.597174749350624 0.643310167999085 mirMAP -0.829638986336471 2.85124185439564e-06 NA NA NA hsa-miR-30d-5p INHBA 0.302504510257496 0.380193536606962 0.597174749350624 0.643310167999085 mirMAP -0.810002974024271 0.000171793130428081 NA NA NA hsa-miR-30e-5p INHBA 0.780047227271616 0.0346714425913016 0.597174749350624 0.643310167999085 mirMAP -1.27059538225699 7.92305049877725e-11 NA NA NA hsa-miR-3607-3p INHBA 1.38015131722213 0.0240067155694847 0.597174749350624 0.643310167999085 mirMAP -0.386722991000475 0.00117665769481931 NA NA NA hsa-miR-374a-5p INHBA 0.278549982012055 0.45888283715888 0.597174749350624 0.643310167999085 mirMAP -0.531291535768356 0.00725261558931535 NA NA NA hsa-miR-664a-3p INHBA 0.249882351950296 0.56171157318348 0.597174749350624 0.643310167999085 mirMAP -0.466978716274 0.00658510269681794 NA NA NA hsa-miR-107 ITGA2 1.49443409571439 0.000130594521065411 2.48937739463293 0.0160407654539565 MirTarget;miRanda;miRNATAP -0.60235086510186 6.08171636894277e-05 NA NA NA hsa-miR-129-5p ITGA2 -2.66843722411409 0.00695783358331245 2.48937739463293 0.0160407654539565 miRanda -0.166845239014 0.00545683203378439 NA NA NA hsa-miR-130b-3p ITGA2 3.9204771543282 1.2714917955808e-11 2.48937739463293 0.0160407654539565 mirMAP -0.26949750894093 0.00618220603286604 NA NA NA hsa-miR-181c-5p ITGA2 -0.302833440762172 0.537532549455539 2.48937739463293 0.0160407654539565 MirTarget -0.498322423732286 3.20866256159181e-05 NA NA NA hsa-miR-181d-5p ITGA2 -0.529098579553155 0.325262124523294 2.48937739463293 0.0160407654539565 MirTarget -0.460006206783873 2.48285148783312e-05 NA NA NA hsa-miR-186-5p ITGA2 0.445443449112564 0.185447310527704 2.48937739463293 0.0160407654539565 mirMAP -0.927691887788398 1.36024992771876e-07 NA NA NA hsa-miR-200b-3p ITGA2 5.56167217794639 6.43540045061709e-16 2.48937739463293 0.0160407654539565 mirMAP -0.300708652888699 0.000201997114046623 NA NA NA hsa-miR-20b-3p ITGA2 3.32857825638616 0.0632388433748268 2.48937739463293 0.0160407654539565 MirTarget -0.370795667992348 4.49651086449395e-11 NA NA NA hsa-miR-301a-3p ITGA2 1.99338115332667 0.000813358604963724 2.48937739463293 0.0160407654539565 mirMAP -0.326299688546253 0.000878198912114417 NA NA NA hsa-miR-30a-5p ITGA2 -0.768430903969183 0.320487552854215 2.48937739463293 0.0160407654539565 miRNAWalker2_validate;mirMAP -0.349994506094588 3.2467603082632e-06 NA NA NA hsa-miR-324-5p ITGA2 1.31253452379847 0.0116806680545163 2.48937739463293 0.0160407654539565 miRanda -0.444704495510645 7.74752785538148e-05 NA NA NA hsa-miR-326 ITGA2 1.76645822596029 0.0367310428720192 2.48937739463293 0.0160407654539565 PITA -0.182648658757677 0.00899805581337897 NA NA NA hsa-miR-335-5p ITGA2 0.167216045757305 0.803897055331049 2.48937739463293 0.0160407654539565 miRNAWalker2_validate -0.36054931089979 3.33306142160341e-05 NA NA NA hsa-miR-362-3p ITGA2 0.679952485897744 0.226148468488576 2.48937739463293 0.0160407654539565 miRanda -0.362980929405073 0.00055693712069407 NA NA NA hsa-miR-429 ITGA2 6.39965293994036 1.96920201593608e-18 2.48937739463293 0.0160407654539565 mirMAP -0.288938497609893 0.000128125948214856 NA NA NA hsa-miR-532-5p ITGA2 -0.297424983759107 0.503934707453099 2.48937739463293 0.0160407654539565 MirTarget -0.852321365536599 5.40124199251107e-11 NA NA NA hsa-miR-7-1-3p ITGA2 1.43074343339835 0.00471215970502094 2.48937739463293 0.0160407654539565 mirMAP -0.372143623171953 0.00135095540108011 NA NA NA hsa-miR-93-3p ITGA2 2.62833115374128 2.28843227834337e-07 2.48937739463293 0.0160407654539565 MirTarget -0.301030896196376 0.00843125839635485 NA NA NA hsa-miR-194-3p ITGA5 1.91743783341496 0.105383373371284 -1.8446504207096 0.0297085003383229 miRNATAP -0.167523590044212 3.75406176722769e-05 NA NA NA hsa-miR-25-3p ITGA5 1.12623030168869 0.00311079344417173 -1.8446504207096 0.0297085003383229 miRNATAP -0.420585827540342 0.000980687689145723 NA NA NA hsa-miR-3065-3p ITGA5 1.89496019576082 0.0308154823923145 -1.8446504207096 0.0297085003383229 miRNATAP -0.258701460823073 1.70453975199898e-06 NA NA NA hsa-miR-30d-5p ITGA5 0.302504510257496 0.380193536606962 -1.8446504207096 0.0297085003383229 miRNATAP -0.607621466097398 1.82825815943687e-05 NA NA NA hsa-miR-429 ITGA5 6.39965293994036 1.96920201593608e-18 -1.8446504207096 0.0297085003383229 miRNATAP -0.433082891873838 5.37646123031644e-13 NA NA NA hsa-miR-141-3p ITGAV 7.30474126597325 1.45115996357606e-24 -0.352039895655465 0.454432205712453 MirTarget -0.100320119594751 0.00348634289909069 NA NA NA hsa-miR-16-2-3p ITGAV 3.79845098071094 1.49120139344659e-13 -0.352039895655465 0.454432205712453 mirMAP -0.14339534840751 0.00402671067495608 NA NA NA hsa-miR-186-5p ITGAV 0.445443449112564 0.185447310527704 -0.352039895655465 0.454432205712453 mirMAP -0.312312632091072 0.000102720591168924 NA NA NA hsa-miR-200a-3p ITGAV 6.336081120041 4.024313571871e-16 -0.352039895655465 0.454432205712453 MirTarget -0.135489080461771 2.53917071546109e-05 NA NA NA hsa-miR-20b-3p ITGAV 3.32857825638616 0.0632388433748268 -0.352039895655465 0.454432205712453 MirTarget -0.100886928603515 0.00010703757543393 NA NA NA hsa-miR-340-5p ITGAV 1.41210478721579 0.00958612942879818 -0.352039895655465 0.454432205712453 MirTarget -0.135365564525711 0.00564845992977706 NA NA NA hsa-miR-363-3p ITGAV 4.27232887548977 8.53979362839458e-06 -0.352039895655465 0.454432205712453 MirTarget -0.108949559747721 5.82239107850678e-05 NA NA NA hsa-miR-429 ITGAV 6.39965293994036 1.96920201593608e-18 -0.352039895655465 0.454432205712453 miRanda -0.127923081922559 0.000178127067563742 NA NA NA hsa-miR-590-3p ITGAV 2.35429565068338 2.79601879608564e-06 -0.352039895655465 0.454432205712453 MirTarget;PITA;miRanda -0.20055477784318 0.000119095540512076 NA NA NA hsa-miR-616-5p ITGAV 2.48416313933027 0.00318247475868827 -0.352039895655465 0.454432205712453 mirMAP -0.160642317931749 3.9832268474519e-05 NA NA NA hsa-miR-16-2-3p ITGB1 3.79845098071094 1.49120139344659e-13 -1.00653525562584 0.0233742054275398 mirMAP -0.127822060458251 0.00679829102276889 NA NA NA hsa-miR-195-3p ITGB1 -2.39100534119332 0.000185405399054065 -1.00653525562584 0.0233742054275398 mirMAP -0.124925043524076 0.00144595463671559 NA NA NA hsa-miR-29c-3p ITGB1 -0.414153610337085 0.529344128062017 -1.00653525562584 0.0233742054275398 MirTarget;miRNATAP -0.181000039570301 1.75141643407349e-06 26766915 MiR 29c inhibits cell growth invasion and migration of pancreatic cancer by targeting ITGB1; Further analysis revealed that ITGB1 is one of the functional target genes of miR-29c and knockdown of ITGB1 inhibited the proliferation migration and invasion of PC cells which was similar to the effects of overexpression of miR-29c pancreatic cancer hsa-miR-3607-3p ITGB1 1.38015131722213 0.0240067155694847 -1.00653525562584 0.0233742054275398 MirTarget -0.181397756406584 8.5867912021978e-06 NA NA NA hsa-miR-429 ITGB1 6.39965293994036 1.96920201593608e-18 -1.00653525562584 0.0233742054275398 miRanda -0.168275635101156 1.38586438823119e-07 NA NA NA hsa-let-7a-5p ITGB3 0.148081801547773 0.645305441523746 -3.67655280362362 0.00223203801274871 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.726886599287972 0.00088047108902417 NA NA NA hsa-let-7b-5p ITGB3 -0.189422992330471 0.651878220048983 -3.67655280362362 0.00223203801274871 MirTarget;miRNATAP -0.466917722728155 0.00482453246097113 NA NA NA hsa-let-7c-5p ITGB3 -2.03831836681378 0.0228401148731997 -3.67655280362362 0.00223203801274871 MirTarget -0.295480032951115 9.7151989404412e-05 23981581 MicroRNA let 7c inhibits migration and invasion of human non small cell lung cancer by targeting ITGB3 and MAP4K3; We then analyzed the potential targets of let-7c and found that ITGB3 and MAP4K3 were directly repressed by let-7c; Collectively our results suggest that let-7c by degrading ITGB3 and MAP4K3 prevents NSCLC metastasis metastasis lung squamous cell cancer hsa-let-7d-5p ITGB3 0.831142050231414 0.0126955498524287 -3.67655280362362 0.00223203801274871 MirTarget -0.631939759107509 0.00257072615968396 NA NA NA hsa-let-7f-5p ITGB3 0.971961126099146 0.0240319857511033 -3.67655280362362 0.00223203801274871 MirTarget;miRNATAP -0.415065991799071 0.00986862803029187 NA NA NA hsa-let-7g-5p ITGB3 0.857251702023746 0.00647597344297273 -3.67655280362362 0.00223203801274871 MirTarget;miRNATAP -0.627271335820792 0.00487356645856055 NA NA NA hsa-miR-221-3p ITGB3 0.94082283577318 0.174749164179978 -3.67655280362362 0.00223203801274871 MirTarget -0.379286409283507 0.00011751707674512 NA NA NA hsa-miR-222-3p ITGB3 1.54730827524553 0.0223014220569407 -3.67655280362362 0.00223203801274871 MirTarget -0.375142007751169 0.000194130386104063 NA NA NA hsa-miR-3607-3p ITGB3 1.38015131722213 0.0240067155694847 -3.67655280362362 0.00223203801274871 MirTarget;mirMAP;miRNATAP -0.399473651029349 0.00035088628883246 NA NA NA hsa-miR-429 ITGB3 6.39965293994036 1.96920201593608e-18 -3.67655280362362 0.00223203801274871 miRanda -0.347218456690496 7.88454627867982e-05 NA NA NA hsa-miR-590-3p ITGB3 2.35429565068338 2.79601879608564e-06 -3.67655280362362 0.00223203801274871 PITA;miRanda -0.580537924410798 1.48574142592059e-05 NA NA NA hsa-miR-155-5p ITGB5 2.81443182173772 7.42530504828797e-05 -0.701207879384589 0.203434330470357 miRNAWalker2_validate -0.152875601100387 0.000414745149089452 NA NA NA hsa-miR-484 ITGB5 1.79050445056016 0.000217287101253701 -0.701207879384589 0.203434330470357 miRNATAP -0.302918195738408 1.88093521370537e-06 NA NA NA hsa-miR-141-3p JUN 7.30474126597325 1.45115996357606e-24 -1.39678224976456 0.0210065056705043 miRNATAP -0.140631808287642 0.00151406596577943 NA NA NA hsa-miR-30a-5p JUN -0.768430903969183 0.320487552854215 -1.39678224976456 0.0210065056705043 miRNAWalker2_validate -0.152843415788565 0.000559974108995951 NA NA NA hsa-miR-590-3p LAMA2 2.35429565068338 2.79601879608564e-06 -3.53377008507832 0.000436975489007485 miRanda -0.373683396051962 0.000941436286040134 NA NA NA hsa-miR-146b-5p LAMC1 1.87569569182453 0.000737241069698886 -1.1345245467724 0.0487516321194313 miRanda -0.16146934050627 0.00583795734888103 NA NA NA hsa-miR-15a-5p LAMC1 2.0535411006904 1.91108976398046e-06 -1.1345245467724 0.0487516321194313 MirTarget -0.233643526162451 0.00188489189895224 NA NA NA hsa-miR-200b-3p LAMC1 5.56167217794639 6.43540045061709e-16 -1.1345245467724 0.0487516321194313 MirTarget;TargetScan -0.168074713864644 0.000182531647838776 NA NA NA hsa-miR-29c-3p LAMC1 -0.414153610337085 0.529344128062017 -1.1345245467724 0.0487516321194313 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.149575116389429 0.00260104788351692 NA NA NA hsa-miR-362-3p LAMC1 0.679952485897744 0.226148468488576 -1.1345245467724 0.0487516321194313 miRanda -0.15670901878609 0.00750072807430818 NA NA NA hsa-miR-452-5p LAMC1 2.45466810475361 0.00114794259949532 -1.1345245467724 0.0487516321194313 MirTarget -0.123251751639601 0.00408263503279682 NA NA NA hsa-miR-642a-5p LAMC1 3.38585273752088 0.000272015814573312 -1.1345245467724 0.0487516321194313 MirTarget -0.168505635479068 8.73035461122514e-05 NA NA NA hsa-miR-942-5p LAMC1 3.36242661558642 1.89848306955335e-10 -1.1345245467724 0.0487516321194313 MirTarget -0.175812717092046 0.00351903554877274 NA NA NA hsa-miR-660-5p LAMC2 -0.0668683798854808 0.885250178390404 4.53104586077785 3.72443772943175e-05 MirTarget -0.72103092680186 9.88253636768622e-08 NA NA NA hsa-miR-186-5p LOX 0.445443449112564 0.185447310527704 0.881717030992129 0.37009820576541 mirMAP -0.519927058077035 0.00213238642577527 NA NA NA hsa-miR-26a-5p LOX -0.352368463397074 0.362040749917446 0.881717030992129 0.37009820576541 mirMAP -0.450546394641226 0.00208382919301486 NA NA NA hsa-miR-3065-3p LOX 1.89496019576082 0.0308154823923145 0.881717030992129 0.37009820576541 miRNATAP -0.172775569745189 0.00632271744678502 NA NA NA hsa-miR-3065-5p LOX 2.14185373842821 0.0609400502269891 0.881717030992129 0.37009820576541 mirMAP -0.166294956413013 0.00607365177860522 NA NA NA hsa-miR-335-5p LOX 0.167216045757305 0.803897055331049 0.881717030992129 0.37009820576541 miRNAWalker2_validate -0.236830535606634 0.00430308013858812 NA NA NA hsa-miR-374b-5p LOX -0.114749866169918 0.764888930049438 0.881717030992129 0.37009820576541 mirMAP -0.469797103677661 0.00145167141489413 NA NA NA hsa-miR-508-3p LOX 0.975099105064348 0.439528954969797 0.881717030992129 0.37009820576541 mirMAP -0.118899930239391 0.0076612274416 NA NA NA hsa-miR-148b-3p LOXL1 1.75622244535669 8.84414356040579e-08 -0.944223535326842 0.155074993417749 miRNAWalker2_validate -0.407232738800303 0.000369331721310166 NA NA NA hsa-miR-93-5p LOXL1 2.65964181833033 2.58315947526774e-08 -0.944223535326842 0.155074993417749 miRNAWalker2_validate -0.29099031576361 0.000162009445393248 NA NA NA hsa-let-7f-2-3p LRP1 1.02768112108475 0.0787293499732611 -1.64293409792207 0.0130745840537971 mirMAP -0.21535869383198 0.00108784368473928 NA NA NA hsa-miR-107 LRP1 1.49443409571439 0.000130594521065411 -1.64293409792207 0.0130745840537971 PITA;miRNATAP -0.454166062397537 2.04639759198932e-06 NA NA NA hsa-miR-200b-3p LRP1 5.56167217794639 6.43540045061709e-16 -1.64293409792207 0.0130745840537971 TargetScan -0.235281981275946 4.88015159391026e-06 NA NA NA hsa-miR-324-5p LRP1 1.31253452379847 0.0116806680545163 -1.64293409792207 0.0130745840537971 miRanda -0.310371124394123 1.55559962995713e-05 NA NA NA hsa-miR-335-5p LRP1 0.167216045757305 0.803897055331049 -1.64293409792207 0.0130745840537971 miRNAWalker2_validate -0.293353836922016 1.02113735687943e-07 NA NA NA hsa-miR-338-5p LRP1 -0.108304629897487 0.894675560494607 -1.64293409792207 0.0130745840537971 miRNAWalker2_validate;MirTarget;PITA;miRNATAP -0.152424803879628 0.000952971851376058 NA NA NA hsa-miR-339-5p LRP1 1.23326828594484 0.0307501214818698 -1.64293409792207 0.0130745840537971 miRanda -0.208127748968768 0.00159189608496939 NA NA NA hsa-miR-429 LRP1 6.39965293994036 1.96920201593608e-18 -1.64293409792207 0.0130745840537971 PITA;miRanda;miRNATAP -0.221463642115046 3.99418810539075e-06 NA NA NA hsa-miR-590-3p LRP1 2.35429565068338 2.79601879608564e-06 -1.64293409792207 0.0130745840537971 PITA;miRanda;miRNATAP -0.255991235046411 0.000535229883952083 NA NA NA hsa-miR-590-5p LRP1 1.51400888103768 0.0023888567923017 -1.64293409792207 0.0130745840537971 miRanda -0.301861974078647 5.77981878269197e-05 NA NA NA hsa-miR-17-3p LRRC15 1.2477858204856 0.00186593270231258 -0.286008638098385 0.83843609864784 mirMAP -0.622766428922189 0.00177708335370871 NA NA NA hsa-miR-200a-3p LRRC15 6.336081120041 4.024313571871e-16 -0.286008638098385 0.83843609864784 mirMAP -0.325808781632756 0.000745886746538477 NA NA NA hsa-miR-30a-5p LRRC15 -0.768430903969183 0.320487552854215 -0.286008638098385 0.83843609864784 mirMAP -0.402354280921149 8.10549070408904e-05 NA NA NA hsa-miR-30b-5p LRRC15 0.0238659735605804 0.953223658270319 -0.286008638098385 0.83843609864784 mirMAP -0.795386728743942 5.34890938411057e-05 NA NA NA hsa-miR-30c-5p LRRC15 0.38723991118075 0.348605235643473 -0.286008638098385 0.83843609864784 mirMAP -0.660279251968686 0.000681863296500486 NA NA NA hsa-miR-30d-5p LRRC15 0.302504510257496 0.380193536606962 -0.286008638098385 0.83843609864784 mirMAP -1.04697576035422 7.22911319095451e-06 NA NA NA hsa-miR-429 LRRC15 6.39965293994036 1.96920201593608e-18 -0.286008638098385 0.83843609864784 miRNATAP -0.268150883174397 0.00893772872155409 NA NA NA hsa-let-7f-1-3p LUM 1.61507869803314 0.00069342464777815 -3.49110411939853 0.000353110928848041 mirMAP -0.397978546668517 0.000719014268649411 NA NA NA hsa-miR-16-2-3p LUM 3.79845098071094 1.49120139344659e-13 -3.49110411939853 0.000353110928848041 mirMAP -0.762019055228725 3.96774827951771e-14 NA NA NA hsa-miR-590-3p LUM 2.35429565068338 2.79601879608564e-06 -3.49110411939853 0.000353110928848041 miRanda;mirMAP -0.350281274752917 0.00144552146683623 NA NA NA hsa-miR-590-5p LUM 1.51400888103768 0.0023888567923017 -3.49110411939853 0.000353110928848041 MirTarget;PITA;miRanda -0.469838665049511 2.43890774155622e-05 NA NA NA hsa-miR-193a-3p MAGEE1 0.646392169474854 0.207134343676122 -2.71239447113346 0.018758939752943 miRanda -0.45172239753481 0.000437999611847234 NA NA NA hsa-miR-21-5p MATN2 2.65163477806992 6.72089787690756e-16 -4.0786586351949 1.28807808428616e-07 miRNATAP -0.373490041239193 0.00476066152834163 NA NA NA hsa-miR-148b-3p MATN3 1.75622244535669 8.84414356040579e-08 -0.815416262678099 0.484160589150242 miRNAWalker2_validate;MirTarget -0.561798391862999 0.00529369312338346 NA NA NA hsa-miR-590-3p MATN3 2.35429565068338 2.79601879608564e-06 -0.815416262678099 0.484160589150242 miRanda;mirMAP -0.340191418775771 0.00900509809931011 NA NA NA hsa-miR-155-5p MEST 2.81443182173772 7.42530504828797e-05 1.88131193482485 0.00456170276034283 miRNAWalker2_validate -0.160412091218775 0.00226193594252836 NA NA NA hsa-miR-29c-3p MEST -0.414153610337085 0.529344128062017 1.88131193482485 0.00456170276034283 MirTarget;miRNATAP -0.179812962125234 0.00173753325811462 NA NA NA hsa-miR-15a-5p MFAP5 2.0535411006904 1.91108976398046e-06 -6.02112429395012 0.00031991851708567 MirTarget -1.01228480693299 3.57457801917418e-06 NA NA NA hsa-miR-15b-3p MFAP5 3.57530146629867 5.89922785773482e-11 -6.02112429395012 0.00031991851708567 MirTarget -0.542458835094591 0.00143097654818331 NA NA NA hsa-miR-15b-5p MFAP5 3.32329949959268 8.40210501034588e-13 -6.02112429395012 0.00031991851708567 MirTarget -0.917022483968632 3.49510777724524e-06 NA NA NA hsa-miR-16-5p MFAP5 2.93575808220754 2.15436817162977e-10 -6.02112429395012 0.00031991851708567 MirTarget -0.96233158088491 1.51510742138141e-06 NA NA NA hsa-miR-200b-3p MFAP5 5.56167217794639 6.43540045061709e-16 -6.02112429395012 0.00031991851708567 TargetScan -0.723893619445999 2.53752538100107e-08 NA NA NA hsa-miR-200c-3p MFAP5 6.47012025883743 2.64500707716408e-26 -6.02112429395012 0.00031991851708567 miRNATAP -0.544156350624235 0.000150370227131591 NA NA NA hsa-miR-374a-5p MFAP5 0.278549982012055 0.45888283715888 -6.02112429395012 0.00031991851708567 mirMAP -0.928491768182532 0.000323623588643253 NA NA NA hsa-miR-429 MFAP5 6.39965293994036 1.96920201593608e-18 -6.02112429395012 0.00031991851708567 miRanda;miRNATAP -0.564694403596867 3.81142454159267e-06 NA NA NA hsa-miR-590-3p MFAP5 2.35429565068338 2.79601879608564e-06 -6.02112429395012 0.00031991851708567 miRanda;mirMAP -0.537106828424036 0.00442820821042918 NA NA NA hsa-miR-944 MGP 7.20925181386398 0.000823207457340648 -4.66177208687827 3.03423400286887e-06 MirTarget -0.161830955037617 6.0018928400414e-07 NA NA NA hsa-miR-29b-2-5p MMP14 -0.596051745078872 0.189540844841389 -0.32230120295878 0.554236197446704 mirMAP -0.350558987045821 2.00581246396678e-07 NA NA NA hsa-miR-3065-3p MMP14 1.89496019576082 0.0308154823923145 -0.32230120295878 0.554236197446704 miRNATAP -0.182787001326225 1.07514466078017e-07 NA NA NA hsa-miR-361-3p MMP14 0.805698609170807 0.0418491665498322 -0.32230120295878 0.554236197446704 mirMAP -0.255296906407484 0.00117094865394402 NA NA NA hsa-miR-532-3p MMP14 0.643755490841218 0.214842585969913 -0.32230120295878 0.554236197446704 miRNATAP -0.250311358544787 2.39816210391933e-05 NA NA NA hsa-miR-142-3p MMP2 4.35304505457969 3.10014573651358e-10 -2.89314383861622 0.00177005074229379 miRanda -0.199457116472176 0.0071560449288481 NA NA NA hsa-miR-17-5p MMP2 2.3269271449522 2.13987445663942e-05 -2.89314383861622 0.00177005074229379 miRNAWalker2_validate;TargetScan -0.580497288445941 4.8738069871025e-10 NA NA NA hsa-miR-2110 MMP2 1.8070969695103 0.00137196847440523 -2.89314383861622 0.00177005074229379 miRNATAP -0.323857666760763 0.000652467493861047 NA NA NA hsa-miR-21-5p MSX1 2.65163477806992 6.72089787690756e-16 -4.19642959068543 3.24025433167506e-05 miRNATAP -0.902353703588755 8.92992381193181e-08 NA NA NA hsa-miR-30d-5p MXRA5 0.302504510257496 0.380193536606962 1.02208023354549 0.300568990512935 miRNATAP -0.487573730252777 0.00328440004720815 NA NA NA hsa-let-7f-1-3p MYLK 1.61507869803314 0.00069342464777815 -5.73620551906387 2.04578586058996e-10 mirMAP -0.345527228769068 0.00189306988683763 NA NA NA hsa-miR-107 MYLK 1.49443409571439 0.000130594521065411 -5.73620551906387 2.04578586058996e-10 miRanda -0.52328668179509 0.000104613033959233 NA NA NA hsa-miR-142-3p MYLK 4.35304505457969 3.10014573651358e-10 -5.73620551906387 2.04578586058996e-10 PITA;miRanda -0.239569429371645 0.00118761669095385 NA NA NA hsa-miR-142-5p MYLK 3.95552531913424 1.49536283724079e-08 -5.73620551906387 2.04578586058996e-10 mirMAP -0.191014127736807 0.0096698426928944 NA NA NA hsa-miR-15a-5p MYLK 2.0535411006904 1.91108976398046e-06 -5.73620551906387 2.04578586058996e-10 MirTarget;miRNATAP -0.746352622349508 3.09520931051036e-10 NA NA NA hsa-miR-15b-5p MYLK 3.32329949959268 8.40210501034588e-13 -5.73620551906387 2.04578586058996e-10 MirTarget;miRNATAP -0.668563659466959 4.80371439869088e-10 NA NA NA hsa-miR-16-2-3p MYLK 3.79845098071094 1.49120139344659e-13 -5.73620551906387 2.04578586058996e-10 mirMAP -0.717871646458153 4.48899070845122e-14 NA NA NA hsa-miR-16-5p MYLK 2.93575808220754 2.15436817162977e-10 -5.73620551906387 2.04578586058996e-10 MirTarget;miRNATAP -0.738050126498185 8.97378463449667e-12 NA NA NA hsa-miR-192-3p MYLK 0.84572845432662 0.480940346018965 -5.73620551906387 2.04578586058996e-10 MirTarget -0.125417057565616 0.00512546678194709 NA NA NA hsa-miR-193a-3p MYLK 0.646392169474854 0.207134343676122 -5.73620551906387 2.04578586058996e-10 miRanda -0.332150041929811 0.00132038386235753 NA NA NA hsa-miR-200b-3p MYLK 5.56167217794639 6.43540045061709e-16 -5.73620551906387 2.04578586058996e-10 TargetScan -0.549224356851321 3.76765810389303e-15 NA NA NA hsa-miR-32-3p MYLK 2.20477794939766 0.0392771274032852 -5.73620551906387 2.04578586058996e-10 mirMAP -0.239444742229131 0.0058723858211936 NA NA NA hsa-miR-33a-3p MYLK 2.06269680799532 0.00156436055383943 -5.73620551906387 2.04578586058996e-10 mirMAP -0.26020629942019 0.00126396708017336 NA NA NA hsa-miR-3653-3p MYLK 2.32416512605984 0.000268136992079666 -5.73620551906387 2.04578586058996e-10 MirTarget -0.221332275677547 0.00715544312833765 NA NA NA hsa-miR-429 MYLK 6.39965293994036 1.96920201593608e-18 -5.73620551906387 2.04578586058996e-10 PITA;miRanda;miRNATAP -0.492612398760663 5.17146669032798e-14 NA NA NA hsa-miR-501-5p MYLK 1.0411896821345 0.0777206709183552 -5.73620551906387 2.04578586058996e-10 MirTarget;PITA;miRNATAP -0.276289069249677 0.00201311653288039 NA NA NA hsa-miR-576-5p MYLK 1.30320223793746 0.00648929463912994 -5.73620551906387 2.04578586058996e-10 PITA;mirMAP -0.449940673979832 4.15943616496535e-05 NA NA NA hsa-miR-589-3p MYLK 1.33205316880069 0.052632683806148 -5.73620551906387 2.04578586058996e-10 mirMAP -0.268266067154719 0.000488628754077984 NA NA NA hsa-miR-590-3p MYLK 2.35429565068338 2.79601879608564e-06 -5.73620551906387 2.04578586058996e-10 MirTarget;miRanda;mirMAP -0.421289419199623 4.49743287459429e-05 NA NA NA hsa-miR-590-5p MYLK 1.51400888103768 0.0023888567923017 -5.73620551906387 2.04578586058996e-10 miRanda -0.33816950107625 0.00138130990480307 NA NA NA hsa-let-7a-5p NID2 0.148081801547773 0.645305441523746 -1.78182912501384 0.0402778329975698 miRNAWalker2_validate;TargetScan;miRNATAP -0.504470968487034 0.00133822224143702 NA NA NA hsa-miR-30c-5p NID2 0.38723991118075 0.348605235643473 -1.78182912501384 0.0402778329975698 miRNATAP -0.369282653662557 0.00226470050597224 NA NA NA hsa-miR-30d-5p NID2 0.302504510257496 0.380193536606962 -1.78182912501384 0.0402778329975698 miRNATAP -0.623230773219511 1.75285277789027e-05 NA NA NA hsa-miR-590-3p NID2 2.35429565068338 2.79601879608564e-06 -1.78182912501384 0.0402778329975698 miRanda;mirMAP -0.311171782042208 0.00134807308033436 NA NA NA hsa-miR-125a-5p NOTCH2 -1.32352790615388 0.00714301627309467 -0.183005214639284 0.701542660353885 miRanda -0.193698044396288 0.000406546208769408 NA NA NA hsa-miR-1287-5p NOTCH2 0.020198871519483 0.975605947457309 -0.183005214639284 0.701542660353885 MirTarget -0.185636029893122 4.62786960353465e-06 NA NA NA hsa-miR-130a-5p NOTCH2 1.58028512890005 0.024346333013728 -0.183005214639284 0.701542660353885 mirMAP -0.132837715500899 0.000646781313089828 NA NA NA hsa-miR-15b-5p NOTCH2 3.32329949959268 8.40210501034588e-13 -0.183005214639284 0.701542660353885 MirTarget -0.159555953544984 0.0045875298736748 NA NA NA hsa-miR-16-5p NOTCH2 2.93575808220754 2.15436817162977e-10 -0.183005214639284 0.701542660353885 miRNAWalker2_validate;MirTarget -0.200320992954935 0.000425956137379177 NA NA NA hsa-miR-17-5p NOTCH2 2.3269271449522 2.13987445663942e-05 -0.183005214639284 0.701542660353885 miRNAWalker2_validate -0.169529439302839 0.00049735138887776 NA NA NA hsa-miR-181b-5p NOTCH2 1.11397227523501 0.0273417050354018 -0.183005214639284 0.701542660353885 MirTarget;mirMAP -0.16247047762051 0.00243649018435159 NA NA NA hsa-miR-18a-3p NOTCH2 3.64944956993027 7.20156641833731e-07 -0.183005214639284 0.701542660353885 MirTarget -0.129568899948815 0.000325258097347774 NA NA NA hsa-miR-25-3p NOTCH2 1.12623030168869 0.00311079344417173 -0.183005214639284 0.701542660353885 miRNAWalker2_validate -0.227988142365454 0.00141552162092909 NA NA NA hsa-miR-29b-3p NOTCH2 0.666547117072858 0.234055379278093 -0.183005214639284 0.701542660353885 MirTarget -0.129692383789341 0.00738306358210304 NA NA NA hsa-miR-30b-5p NOTCH2 0.0238659735605804 0.953223658270319 -0.183005214639284 0.701542660353885 mirMAP -0.336827698747 3.83284637794388e-07 NA NA NA hsa-miR-423-5p NOTCH2 0.227366878624794 0.5653498335202 -0.183005214639284 0.701542660353885 MirTarget -0.222039895627339 0.00132742633847468 NA NA NA hsa-miR-590-3p NOTCH2 2.35429565068338 2.79601879608564e-06 -0.183005214639284 0.701542660353885 miRanda -0.179230248536852 0.000723167200406355 NA NA NA hsa-miR-590-5p NOTCH2 1.51400888103768 0.0023888567923017 -0.183005214639284 0.701542660353885 miRanda -0.170357474195375 0.0016299088847882 NA NA NA hsa-miR-7-1-3p NOTCH2 1.43074343339835 0.00471215970502094 -0.183005214639284 0.701542660353885 MirTarget;mirMAP -0.188530173299219 0.00039076714007433 NA NA NA hsa-miR-92a-3p NOTCH2 1.87892405805529 1.27013821556583e-05 -0.183005214639284 0.701542660353885 miRNAWalker2_validate -0.198240648839897 0.00148511169695724 NA NA NA hsa-miR-155-5p NT5E 2.81443182173772 7.42530504828797e-05 -3.30233147369154 0.00422378924982999 miRNAWalker2_validate -0.312770519149444 0.00061759973695176 NA NA NA hsa-miR-30d-5p NT5E 0.302504510257496 0.380193536606962 -3.30233147369154 0.00422378924982999 miRNATAP -0.518188888060106 0.00797476714276535 NA NA NA hsa-miR-34a-5p NT5E 0.830377770217786 0.0477544831885907 -3.30233147369154 0.00422378924982999 miRNAWalker2_validate -0.437075118352344 0.00584538149705717 NA NA NA hsa-miR-3607-3p NT5E 1.38015131722213 0.0240067155694847 -3.30233147369154 0.00422378924982999 mirMAP -0.398243635749175 0.000199926479019936 NA NA NA hsa-miR-374a-5p NT5E 0.278549982012055 0.45888283715888 -3.30233147369154 0.00422378924982999 mirMAP -0.462709694367474 0.00945919446983281 NA NA NA hsa-miR-30c-5p NTM 0.38723991118075 0.348605235643473 0.907868853322306 0.345156469921149 miRNATAP -0.397362754725915 0.00293659584612369 NA NA NA hsa-miR-30d-5p NTM 0.302504510257496 0.380193536606962 0.907868853322306 0.345156469921149 miRNATAP -0.695560258068872 1.4114604735522e-05 NA NA NA hsa-miR-942-5p NTM 3.36242661558642 1.89848306955335e-10 0.907868853322306 0.345156469921149 MirTarget -0.327896302435741 0.00108548477136333 NA NA NA hsa-miR-29a-3p OXTR -0.638239697975974 0.251923581881716 -0.331563850798576 0.661049728460972 miRNATAP -0.237071230092838 0.0021052886374085 NA NA NA hsa-miR-29b-3p OXTR 0.666547117072858 0.234055379278093 -0.331563850798576 0.661049728460972 miRNATAP -0.306748321269649 5.74102820053503e-05 NA NA NA hsa-miR-29c-3p OXTR -0.414153610337085 0.529344128062017 -0.331563850798576 0.661049728460972 miRNATAP -0.222342141184603 0.00062086191985116 NA NA NA hsa-miR-590-3p OXTR 2.35429565068338 2.79601879608564e-06 -0.331563850798576 0.661049728460972 mirMAP -0.249712221678987 0.00305244844629365 NA NA NA hsa-miR-944 OXTR 7.20925181386398 0.000823207457340648 -0.331563850798576 0.661049728460972 mirMAP -0.163560401044623 4.96293543272921e-12 NA NA NA hsa-miR-192-5p PCOLCE2 1.77716187978541 0.113485496183047 -3.68267829015652 0.0194097917118246 miRNAWalker2_validate -0.210372317889144 0.00819422885593375 NA NA NA hsa-miR-338-5p PCOLCE2 -0.108304629897487 0.894675560494607 -3.68267829015652 0.0194097917118246 miRNATAP -0.389458827967371 0.000385607952747738 NA NA NA hsa-miR-224-5p PDGFRB 4.2725754042941 6.99983365278436e-06 -3.00627214348519 7.34667780692721e-05 miRNAWalker2_validate -0.146201861578625 0.00110933147204739 NA NA NA hsa-miR-34a-5p PDGFRB 0.830377770217786 0.0477544831885907 -3.00627214348519 7.34667780692721e-05 MirTarget -0.312602617436571 0.00280746999217784 24837198 MicroRNA 34A inhibits the growth invasion and metastasis of gastric cancer by targeting PDGFR and MET expression; In this study our aim was to identify the miRNAs that target PDGFR-α/β and to study the functions of these miRNAs miR-34a was predicted to target PDGFR and luciferase reporter assays showed that miR-34a could directly target PDGFR; Moreover the cancer-associated cell signalling pathway was studied and we found that miR-34a could inhibit Akt PKB protein kinase B phosphorylation which was restored by the overexpression of both PDGFR and MET; In conclusion miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K phosphoinositide 3-kinase/Akt pathway metastasis gastric cancer hsa-miR-361-3p PDGFRB 0.805698609170807 0.0418491665498322 -3.00627214348519 7.34667780692721e-05 MirTarget -0.366005767450926 0.000965550104549401 NA NA NA hsa-miR-484 PDGFRB 1.79050445056016 0.000217287101253701 -3.00627214348519 7.34667780692721e-05 mirMAP -0.32636125869027 0.00025262001509626 NA NA NA hsa-miR-142-3p PFN2 4.35304505457969 3.10014573651358e-10 -0.477232396589523 0.62094549903535 miRanda -0.41077241202493 5.03307934175174e-08 NA NA NA hsa-miR-150-5p PFN2 1.76769157530064 0.0593795975117846 -0.477232396589523 0.62094549903535 miRNATAP -0.324131748778042 1.24648523455634e-08 NA NA NA hsa-miR-342-3p PFN2 1.31107714473009 0.0207211910724662 -0.477232396589523 0.62094549903535 miRanda;miRNATAP -0.286078556030312 0.00301602345699556 NA NA NA hsa-miR-195-3p PLAUR -2.39100534119332 0.000185405399054065 1.06508487439709 0.094728457810679 MirTarget -0.294030547436048 1.16867463466087e-07 NA NA NA hsa-miR-23b-3p PLOD1 -0.581135273821923 0.190478897170459 -0.166021052085228 0.71759460065181 miRNAWalker2_validate -0.257144614879083 1.09406819053389e-05 NA NA NA hsa-miR-23b-5p PLOD1 1.40234742241472 0.033464045391494 -0.166021052085228 0.71759460065181 MirTarget -0.104029014580484 0.00949683516231445 NA NA NA hsa-miR-26a-5p PLOD2 -0.352368463397074 0.362040749917446 0.693918764934867 0.336056487074125 MirTarget;miRNATAP -0.432713206674916 4.98116920932653e-05 26983694;27310702 Thus our data showed that two genes promoting metastasis LOXL2 and PLOD2 were epigenetically regulated by tumor-suppressive microRNAs miR-26a and miR-26b providing important insights into the molecular mechanisms of RCC metastasis;The gene encoding procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 PLOD2 a collagen crosslinking enzyme was directly regulated by miR-26a-5p and miR-26b-5p; PLOD2 which is associated with the stiffness of the extracellular matrix was directly regulated by miR-26a-5p and miR-26b-5p and may be a good prognostic marker in patients with BC metastasis; kidney renal cell cancer;bladder cancer hsa-miR-103a-3p PMEPA1 0.990919087251708 0.00468308601422847 -0.442358517847733 0.562223736384141 mirMAP -0.344955171103249 0.0058813897110119 NA NA NA hsa-miR-130b-3p PMEPA1 3.9204771543282 1.2714917955808e-11 -0.442358517847733 0.562223736384141 MirTarget;miRNATAP -0.215054594882871 0.00290908797015697 NA NA NA hsa-miR-15a-5p PMEPA1 2.0535411006904 1.91108976398046e-06 -0.442358517847733 0.562223736384141 mirMAP -0.263213487422776 0.00828958180443993 NA NA NA hsa-miR-15b-5p PMEPA1 3.32329949959268 8.40210501034588e-13 -0.442358517847733 0.562223736384141 mirMAP -0.287387323845076 0.00140613777638125 NA NA NA hsa-miR-16-5p PMEPA1 2.93575808220754 2.15436817162977e-10 -0.442358517847733 0.562223736384141 mirMAP -0.259230015412228 0.00455730455701165 NA NA NA hsa-miR-32-5p PMEPA1 2.93035124381469 5.00149131394151e-10 -0.442358517847733 0.562223736384141 miRNATAP -0.253459395447018 0.00473747463796703 NA NA NA hsa-miR-429 PMEPA1 6.39965293994036 1.96920201593608e-18 -0.442358517847733 0.562223736384141 miRNATAP -0.213526828461622 0.000116612719537774 NA NA NA hsa-miR-532-3p PMEPA1 0.643755490841218 0.214842585969913 -0.442358517847733 0.562223736384141 mirMAP -0.444187870172669 6.87316527645455e-08 NA NA NA hsa-miR-590-3p PMEPA1 2.35429565068338 2.79601879608564e-06 -0.442358517847733 0.562223736384141 miRanda;mirMAP -0.295021686056032 0.000508536892021951 NA NA NA hsa-miR-9-5p PMEPA1 1.79620806707734 0.14526963042518 -0.442358517847733 0.562223736384141 mirMAP -0.166754082834219 1.30050395106659e-06 NA NA NA hsa-miR-92a-3p PMEPA1 1.87892405805529 1.27013821556583e-05 -0.442358517847733 0.562223736384141 miRNATAP -0.314124383829536 0.00167149227138712 NA NA NA hsa-miR-330-3p PMP22 2.49094236945806 0.000129367003214715 -3.99868485276207 1.43437316984741e-09 PITA -0.213148869064223 0.000273545677523537 NA NA NA hsa-miR-429 PMP22 6.39965293994036 1.96920201593608e-18 -3.99868485276207 1.43437316984741e-09 PITA;miRanda;miRNATAP -0.313516082689027 8.56178391015548e-11 NA NA NA hsa-miR-590-3p PMP22 2.35429565068338 2.79601879608564e-06 -3.99868485276207 1.43437316984741e-09 miRanda -0.21738616590217 0.00415890439921446 NA NA NA hsa-miR-651-5p PMP22 2.63593644285064 2.87092871839488e-05 -3.99868485276207 1.43437316984741e-09 MirTarget -0.204314581628084 0.000714231479720061 NA NA NA hsa-miR-590-3p POSTN 2.35429565068338 2.79601879608564e-06 -2.71639570506067 0.0426491966554371 mirMAP -0.47201974183449 0.00163087354545359 NA NA NA hsa-miR-106a-5p PRRX1 3.98693608217557 9.37722470816656e-07 -3.33510569764646 0.000414916352278086 MirTarget;miRNATAP -0.342271548533728 9.44247829631778e-08 NA NA NA hsa-miR-106b-5p PRRX1 2.80565545918114 1.14547999022566e-09 -3.33510569764646 0.000414916352278086 MirTarget;miRNATAP -0.612664647732965 5.84890865892898e-08 26617763 Down regualtion of miR 106b induces epithelial mesenchymal transition but suppresses metastatic colonization by targeting Prrx1 in colorectal cancer; We identified Prrx1 was a direct target of miR-106b through using target prediction algorithms and dual-Luciferase reporter assay; Moreover Moreover we also found TGF-β1 could down-regulate miR-106b and simultaneously miR-106b also influences the expression of TGF-β1 establishing a negative feedback loop to regulate the expression of Prrx1 together colorectal cancer hsa-miR-148b-5p PRRX1 2.80812018666078 3.97536665756679e-08 -3.33510569764646 0.000414916352278086 MirTarget -0.419949083473889 4.83119518976328e-05 NA NA NA hsa-miR-16-2-3p PRRX1 3.79845098071094 1.49120139344659e-13 -3.33510569764646 0.000414916352278086 MirTarget -0.614429058556015 5.08787365954607e-10 NA NA NA hsa-miR-17-5p PRRX1 2.3269271449522 2.13987445663942e-05 -3.33510569764646 0.000414916352278086 MirTarget;TargetScan;miRNATAP -0.549644474322769 9.89405055044356e-09 NA NA NA hsa-miR-1976 PRRX1 3.27217274919653 3.16337235854532e-12 -3.33510569764646 0.000414916352278086 MirTarget;miRNATAP -0.33185750497587 0.00295952868870672 NA NA NA hsa-miR-200b-5p PRRX1 6.81954246537908 6.31100593281326e-24 -3.33510569764646 0.000414916352278086 mirMAP -0.427912643360488 3.30039341200988e-09 NA NA NA hsa-miR-20a-5p PRRX1 2.13553469875764 0.000181201072324354 -3.33510569764646 0.000414916352278086 MirTarget;miRNATAP -0.495637742547451 8.60729647832446e-08 NA NA NA hsa-miR-20b-5p PRRX1 4.5662923200279 4.75238200639144e-05 -3.33510569764646 0.000414916352278086 MirTarget;miRNATAP -0.21969960778909 2.75221891381936e-06 NA NA NA hsa-miR-32-3p PRRX1 2.20477794939766 0.0392771274032852 -3.33510569764646 0.000414916352278086 mirMAP;miRNATAP -0.248865990855011 0.00516258639156129 NA NA NA hsa-miR-335-3p PRRX1 1.19503568251824 0.0938852560631551 -3.33510569764646 0.000414916352278086 MirTarget;mirMAP -0.275528735374556 0.000256076764085755 NA NA NA hsa-miR-338-3p PRRX1 0.447551118940466 0.558485097370031 -3.33510569764646 0.000414916352278086 miRanda -0.245954342408225 0.000479049154417874 NA NA NA hsa-miR-500a-5p PRRX1 0.0170829425378565 0.973960207660626 -3.33510569764646 0.000414916352278086 mirMAP -0.298373666818396 0.00416216122625643 NA NA NA hsa-miR-550a-3p PRRX1 2.59872127213466 0.00155498164206068 -3.33510569764646 0.000414916352278086 miRNATAP -0.317785947996747 6.72731303405772e-05 NA NA NA hsa-miR-576-5p PRRX1 1.30320223793746 0.00648929463912994 -3.33510569764646 0.000414916352278086 mirMAP -0.2936905222435 0.00956185725097599 NA NA NA hsa-miR-616-5p PRRX1 2.48416313933027 0.00318247475868827 -3.33510569764646 0.000414916352278086 mirMAP -0.311361471463531 9.04602149424283e-05 NA NA NA hsa-miR-93-5p PRRX1 2.65964181833033 2.58315947526774e-08 -3.33510569764646 0.000414916352278086 MirTarget;miRNATAP -0.591054444437851 6.62701347813384e-08 NA NA NA hsa-miR-96-5p PRRX1 5.62521466029286 1.54938806718028e-10 -3.33510569764646 0.000414916352278086 MirTarget;TargetScan -0.293833034126993 5.01804036358615e-05 NA NA NA hsa-miR-106a-5p PTHLH 3.98693608217557 9.37722470816656e-07 0.454636912665883 0.774558722511139 MirTarget;miRNATAP -0.416696900198168 0.00011269358158977 NA NA NA hsa-miR-15a-5p PTHLH 2.0535411006904 1.91108976398046e-06 0.454636912665883 0.774558722511139 MirTarget -0.599017367731227 0.00384832958220049 NA NA NA hsa-miR-200b-3p PTHLH 5.56167217794639 6.43540045061709e-16 0.454636912665883 0.774558722511139 MirTarget;TargetScan -0.482681135069172 9.36755055899943e-05 NA NA NA hsa-miR-20b-5p PTHLH 4.5662923200279 4.75238200639144e-05 0.454636912665883 0.774558722511139 MirTarget -0.329900995746747 2.49078194573172e-05 NA NA NA hsa-miR-3065-3p PTHLH 1.89496019576082 0.0308154823923145 0.454636912665883 0.774558722511139 MirTarget;miRNATAP -0.368710357502968 0.000284906876428034 NA NA NA hsa-miR-429 PTHLH 6.39965293994036 1.96920201593608e-18 0.454636912665883 0.774558722511139 MirTarget;PITA;miRanda -0.344115252365147 0.00298432959546873 NA NA NA hsa-miR-592 PTHLH 2.80403350008555 0.0293520213681333 0.454636912665883 0.774558722511139 PITA -0.266464144427788 0.00180477934700151 NA NA NA hsa-miR-21-5p PTX3 2.65163477806992 6.72089787690756e-16 -3.81681259494014 0.00481153739370009 miRNAWalker2_validate -0.76855516104286 0.000739646725779168 NA NA NA hsa-miR-224-5p PTX3 4.2725754042941 6.99983365278436e-06 -3.81681259494014 0.00481153739370009 MirTarget -0.281041818248112 0.00040651816767666 NA NA NA hsa-miR-944 PTX3 7.20925181386398 0.000823207457340648 -3.81681259494014 0.00481153739370009 PITA;mirMAP -0.114953516768066 0.00918414247328685 NA NA NA hsa-miR-150-5p PVR 1.76769157530064 0.0593795975117846 0.336946004746903 0.538375290027001 mirMAP -0.10203798945811 0.00190024135251666 NA NA NA hsa-miR-218-5p PVR -1.62589026509455 0.0400573414088521 0.336946004746903 0.538375290027001 mirMAP -0.122167615566878 0.00170143875254753 NA NA NA hsa-miR-362-3p PVR 0.679952485897744 0.226148468488576 0.336946004746903 0.538375290027001 miRanda -0.152331496373839 0.0061184953778001 NA NA NA hsa-miR-101-5p QSOX1 -1.41522721523565 0.0166784131265028 -0.596664592871825 0.282204509218331 mirMAP -0.173293905523658 0.00109306801148643 NA NA NA hsa-miR-1271-5p QSOX1 0.212382644103427 0.742544160267329 -0.596664592871825 0.282204509218331 mirMAP -0.154483458054884 0.00151375848033735 NA NA NA hsa-miR-149-5p QSOX1 1.18551753240939 0.197439607622379 -0.596664592871825 0.282204509218331 mirMAP -0.166775811186058 6.94462395838727e-07 NA NA NA hsa-miR-150-5p QSOX1 1.76769157530064 0.0593795975117846 -0.596664592871825 0.282204509218331 MirTarget -0.123154913263586 0.000207916966161128 NA NA NA hsa-miR-224-5p QSOX1 4.2725754042941 6.99983365278436e-06 -0.596664592871825 0.282204509218331 mirMAP -0.122087998622604 0.000156252454351529 NA NA NA hsa-miR-23b-3p QSOX1 -0.581135273821923 0.190478897170459 -0.596664592871825 0.282204509218331 mirMAP -0.312290975700767 1.03026279429354e-05 NA NA NA hsa-miR-23b-5p QSOX1 1.40234742241472 0.033464045391494 -0.596664592871825 0.282204509218331 mirMAP -0.148192711019585 0.00223184705204341 NA NA NA hsa-miR-24-3p QSOX1 1.55853749533999 0.000524726461381821 -0.596664592871825 0.282204509218331 MirTarget;mirMAP -0.205258344255028 0.00333017795757136 NA NA NA hsa-miR-27b-5p QSOX1 0.213392605793392 0.71562473353293 -0.596664592871825 0.282204509218331 mirMAP -0.285985420469105 6.56977843029017e-08 NA NA NA hsa-miR-342-3p QSOX1 1.31107714473009 0.0207211910724662 -0.596664592871825 0.282204509218331 mirMAP -0.290098158718432 1.04559137605472e-07 NA NA NA hsa-miR-342-5p QSOX1 1.3865615438184 0.0153598969109545 -0.596664592871825 0.282204509218331 mirMAP -0.266685411765925 8.5895039341225e-07 NA NA NA hsa-miR-374b-3p QSOX1 0.501845732983925 0.343338908602826 -0.596664592871825 0.282204509218331 mirMAP -0.162698104858365 0.00695362141426134 NA NA NA hsa-miR-378a-3p QSOX1 1.46612141870273 0.0466660641196872 -0.596664592871825 0.282204509218331 mirMAP -0.175132529060423 3.32608598035314e-05 NA NA NA hsa-miR-378a-5p QSOX1 1.25775140086104 0.0500877723587615 -0.596664592871825 0.282204509218331 mirMAP -0.13688292932199 0.00513553641225376 NA NA NA hsa-miR-452-5p QSOX1 2.45466810475361 0.00114794259949532 -0.596664592871825 0.282204509218331 mirMAP -0.158273456652526 0.000115283755053483 NA NA NA hsa-miR-590-3p QSOX1 2.35429565068338 2.79601879608564e-06 -0.596664592871825 0.282204509218331 mirMAP -0.163949113118696 0.0081045914036416 NA NA NA hsa-miR-107 RGS4 1.49443409571439 0.000130594521065411 -0.178002385694984 0.862224734872682 MirTarget;miRanda;miRNATAP -0.481296191869245 0.00124022128048788 NA NA NA hsa-miR-16-2-3p RGS4 3.79845098071094 1.49120139344659e-13 -0.178002385694984 0.862224734872682 MirTarget;mirMAP -0.621042309972171 5.79162140814545e-09 NA NA NA hsa-miR-17-5p RGS4 2.3269271449522 2.13987445663942e-05 -0.178002385694984 0.862224734872682 TargetScan -0.458234969421499 1.09477239965211e-05 NA NA NA hsa-miR-616-5p RGS4 2.48416313933027 0.00318247475868827 -0.178002385694984 0.862224734872682 MirTarget;mirMAP -0.279251521363886 0.00113965273763869 NA NA NA hsa-miR-224-3p RHOB 2.84876340814503 0.000179138399939161 -2.78595678578922 0.000116259948243673 mirMAP -0.159896072869888 0.00322853421506352 NA NA NA hsa-miR-155-5p SCG2 2.81443182173772 7.42530504828797e-05 -3.29178166624516 0.000890237288562905 MirTarget;miRNATAP -0.449978125925254 5.49888682326258e-09 NA NA NA hsa-miR-452-3p SCG2 2.97956996345436 0.000203580834647624 -3.29178166624516 0.000890237288562905 MirTarget -0.322186239177252 3.27774109780518e-06 NA NA NA hsa-miR-10a-5p SDC1 -0.482300926520507 0.594608783320466 6.15783198823573 9.83580788527815e-17 MirTarget;miRNATAP -0.282137458890172 3.61424933229097e-09 NA NA NA hsa-miR-10b-5p SDC1 -3.08172917642729 4.22675074435126e-09 6.15783198823573 9.83580788527815e-17 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.238100160483548 0.00399907995542126 22573479 In breast cancer overexpression of the transmembrane heparan sulfate proteoglycan syndecan-1 a predicted target of the oncomiR miR-10b correlates with poor clinical outcome; To investigate the potential functional relationship of miR-10b and syndecan-1 MDA-MB-231 and MCF-7 breast cancer cells were transiently transfected with pre-miR-10b syndecan-1 siRNA or control reagents respectively; miR-10b overexpression induced post-transcriptional downregulation of syndecan-1 as demonstrated by quantitative real-time PCR qPCR flow cytometry and 3'UTR luciferase assays resulting in increased cancer cell migration and matrigel invasiveness; We conclude that syndecan-1 is a novel target of the oncomiR miR-10b cell migration breast cancer hsa-miR-125a-5p SDC1 -1.32352790615388 0.00714301627309467 6.15783198823573 9.83580788527815e-17 mirMAP -0.472181936847305 1.07587882459099e-07 NA NA NA hsa-miR-28-5p SDC1 -0.815636722979196 0.0221199948901761 6.15783198823573 9.83580788527815e-17 miRanda;miRNATAP -0.365208294232062 0.00385732352329703 NA NA NA hsa-miR-338-3p SDC1 0.447551118940466 0.558485097370031 6.15783198823573 9.83580788527815e-17 miRanda -0.213856987797533 0.000210602469745225 NA NA NA hsa-miR-375 SDC1 3.3784490463318 0.0449946294355695 6.15783198823573 9.83580788527815e-17 miRNAWalker2_validate -0.105673044116467 4.63442230072054e-05 NA NA NA hsa-miR-660-5p SDC1 -0.0668683798854808 0.885250178390404 6.15783198823573 9.83580788527815e-17 MirTarget;miRNATAP -0.277487760402985 0.00408428516321968 NA NA NA hsa-miR-30c-5p SERPINE1 0.38723991118075 0.348605235643473 0.617692230647947 0.572474588134307 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.430478549390397 0.00464929561193146 NA NA NA hsa-miR-30d-5p SERPINE1 0.302504510257496 0.380193536606962 0.617692230647947 0.572474588134307 miRNATAP -0.571023174230567 0.00187005473771538 NA NA NA hsa-miR-34a-5p SERPINE1 0.830377770217786 0.0477544831885907 0.617692230647947 0.572474588134307 miRNATAP -0.454822685947182 0.00229694402077437 NA NA NA hsa-miR-378a-5p SERPINE1 1.25775140086104 0.0500877723587615 0.617692230647947 0.572474588134307 MirTarget -0.403730798540002 2.50727400864339e-05 NA NA NA hsa-miR-99a-5p SERPINE1 -2.72139054000803 0.00621971944534118 0.617692230647947 0.572474588134307 miRNAWalker2_validate -0.208155381578803 0.000740541769690584 NA NA NA hsa-miR-146b-5p SERPINE2 1.87569569182453 0.000737241069698886 -0.838233339394727 0.452560780178739 miRanda -0.379237197337096 0.000796699461342051 NA NA NA hsa-miR-29c-3p SERPINH1 -0.414153610337085 0.529344128062017 -0.466247251188365 0.389315810763294 miRNATAP -0.181692630069177 8.8921719889745e-05 NA NA NA hsa-miR-3065-3p SERPINH1 1.89496019576082 0.0308154823923145 -0.466247251188365 0.389315810763294 miRNATAP -0.112737853649937 0.00115458860112007 NA NA NA hsa-miR-429 SERPINH1 6.39965293994036 1.96920201593608e-18 -0.466247251188365 0.389315810763294 miRanda -0.110760851802573 0.00505938386222625 NA NA NA hsa-miR-16-1-3p SFRP1 2.83281226969693 7.54359864580834e-09 -4.05099494825295 0.00788885256174047 MirTarget -0.549041537326192 0.00156963680356568 NA NA NA hsa-miR-182-5p SFRP1 5.86988712704738 1.22411588571584e-15 -4.05099494825295 0.00788885256174047 mirMAP -0.37114475228972 0.000961641414082013 NA NA NA hsa-miR-19b-1-5p SFRP1 1.51335451095424 0.0014717605268143 -4.05099494825295 0.00788885256174047 MirTarget -0.505630617444352 0.00568002812072431 NA NA NA hsa-miR-203a-3p SFRP1 6.35084246337388 7.89944323347948e-08 -4.05099494825295 0.00788885256174047 MirTarget -0.346403144409134 9.53807015666787e-07 NA NA NA hsa-miR-33a-3p SFRP1 2.06269680799532 0.00156436055383943 -4.05099494825295 0.00788885256174047 MirTarget -0.687662787724045 1.5419508092046e-07 NA NA NA hsa-miR-429 SFRP1 6.39965293994036 1.96920201593608e-18 -4.05099494825295 0.00788885256174047 miRNATAP -0.634291762958993 7.50057649683851e-09 NA NA NA hsa-miR-501-5p SFRP1 1.0411896821345 0.0777206709183552 -4.05099494825295 0.00788885256174047 mirMAP -0.396225021182035 0.00725128386303335 NA NA NA hsa-miR-940 SFRP1 3.78496690968119 4.75227557809023e-05 -4.05099494825295 0.00788885256174047 MirTarget -0.304584104323152 0.00701763875280759 NA NA NA hsa-miR-96-5p SFRP1 5.62521466029286 1.54938806718028e-10 -4.05099494825295 0.00788885256174047 mirMAP -0.392815384619956 0.000786676354596085 NA NA NA hsa-miR-144-5p SFRP4 1.01673279814999 0.403344913421629 -5.17574172449817 0.00555408538544092 MirTarget -0.359839289193151 3.20171457086971e-05 NA NA NA hsa-miR-155-5p SGCB 2.81443182173772 7.42530504828797e-05 -2.01454769878579 0.000173106453387292 miRNATAP -0.227229591912996 6.2091039539608e-08 NA NA NA hsa-miR-21-5p SGCB 2.65163477806992 6.72089787690756e-16 -2.01454769878579 0.000173106453387292 miRNAWalker2_validate -0.397230826099528 9.99796069408326e-06 NA NA NA hsa-miR-32-5p SGCB 2.93035124381469 5.00149131394151e-10 -2.01454769878579 0.000173106453387292 mirMAP -0.224173784613868 0.000412399791310102 24348862 microRNA 32 inhibits the proliferation and invasion of the SGC 7901 gastric cancer cell line in vitro gastric cancer hsa-miR-330-5p SGCB 2.25110496739954 0.000275527655397415 -2.01454769878579 0.000173106453387292 miRanda -0.247106823929404 3.49449069471422e-07 NA NA NA hsa-miR-590-3p SGCB 2.35429565068338 2.79601879608564e-06 -2.01454769878579 0.000173106453387292 miRNAWalker2_validate;miRanda;mirMAP -0.207666629527496 0.000567722297152766 NA NA NA hsa-let-7d-5p SGCD 0.831142050231414 0.0126955498524287 -4.54262936780335 0.000169922663050445 miRNATAP -0.78107169974927 0.000208433547786598 NA NA NA hsa-let-7g-5p SGCD 0.857251702023746 0.00647597344297273 -4.54262936780335 0.000169922663050445 miRNATAP -0.684339974615817 0.00229928664603113 NA NA NA hsa-miR-106b-5p SGCD 2.80565545918114 1.14547999022566e-09 -4.54262936780335 0.000169922663050445 mirMAP -0.700526030964996 1.45945964872867e-06 NA NA NA hsa-miR-130a-5p SGCD 1.58028512890005 0.024346333013728 -4.54262936780335 0.000169922663050445 mirMAP -0.279741118681625 0.00524634924176776 NA NA NA hsa-miR-142-5p SGCD 3.95552531913424 1.49536283724079e-08 -4.54262936780335 0.000169922663050445 miRNATAP -0.453100437969963 2.14638842964857e-06 NA NA NA hsa-miR-144-5p SGCD 1.01673279814999 0.403344913421629 -4.54262936780335 0.000169922663050445 mirMAP -0.160492897898907 0.00465445863260639 NA NA NA hsa-miR-146a-5p SGCD 2.64646698525354 0.000280611928973036 -4.54262936780335 0.000169922663050445 mirMAP -0.267811085852073 0.00443255769749072 NA NA NA hsa-miR-148b-5p SGCD 2.80812018666078 3.97536665756679e-08 -4.54262936780335 0.000169922663050445 mirMAP -0.605780892530345 4.37020080762115e-06 NA NA NA hsa-miR-15a-5p SGCD 2.0535411006904 1.91108976398046e-06 -4.54262936780335 0.000169922663050445 miRNATAP -0.619127111429518 9.4967541529129e-05 NA NA NA hsa-miR-15b-5p SGCD 3.32329949959268 8.40210501034588e-13 -4.54262936780335 0.000169922663050445 miRNATAP -0.528898941754897 0.000234001524213351 NA NA NA hsa-miR-16-2-3p SGCD 3.79845098071094 1.49120139344659e-13 -4.54262936780335 0.000169922663050445 mirMAP -0.848575333548683 1.60319377978038e-11 NA NA NA hsa-miR-16-5p SGCD 2.93575808220754 2.15436817162977e-10 -4.54262936780335 0.000169922663050445 miRNATAP -0.839612151095421 4.65067245995625e-09 NA NA NA hsa-miR-17-5p SGCD 2.3269271449522 2.13987445663942e-05 -4.54262936780335 0.000169922663050445 mirMAP -0.545583203628238 1.11384310679595e-05 NA NA NA hsa-miR-19a-3p SGCD 2.17020503944519 0.00122084653711062 -4.54262936780335 0.000169922663050445 mirMAP -0.353231653453299 0.000546860785050846 NA NA NA hsa-miR-19b-3p SGCD 1.67581705793313 0.000858910586302716 -4.54262936780335 0.000169922663050445 mirMAP -0.497387536578316 0.000280859353317558 NA NA NA hsa-miR-200c-3p SGCD 6.47012025883743 2.64500707716408e-26 -4.54262936780335 0.000169922663050445 mirMAP -0.458913256571874 8.86666381359416e-06 NA NA NA hsa-miR-20a-5p SGCD 2.13553469875764 0.000181201072324354 -4.54262936780335 0.000169922663050445 mirMAP -0.501851650805316 2.73728343694687e-05 NA NA NA hsa-miR-21-3p SGCD 3.50297439576639 6.39946844099206e-10 -4.54262936780335 0.000169922663050445 mirMAP -0.70817699994157 1.12370757115623e-09 NA NA NA hsa-miR-23a-3p SGCD 0.925125296618358 0.0127293543936914 -4.54262936780335 0.000169922663050445 mirMAP -0.593258032333119 0.00166242745544479 NA NA NA hsa-miR-25-3p SGCD 1.12623030168869 0.00311079344417173 -4.54262936780335 0.000169922663050445 mirMAP -0.528735439488444 0.00396753720773356 NA NA NA hsa-miR-29b-1-5p SGCD 0.33698032160171 0.598092174563471 -4.54262936780335 0.000169922663050445 mirMAP -0.375213257889629 0.000562134199769304 NA NA NA hsa-miR-32-3p SGCD 2.20477794939766 0.0392771274032852 -4.54262936780335 0.000169922663050445 mirMAP -0.48126677926368 2.06831194565805e-05 NA NA NA hsa-miR-32-5p SGCD 2.93035124381469 5.00149131394151e-10 -4.54262936780335 0.000169922663050445 mirMAP -0.800102015748249 1.3758252263203e-08 NA NA NA hsa-miR-331-5p SGCD 1.02712086964089 0.0262526092356277 -4.54262936780335 0.000169922663050445 mirMAP -0.581441109284872 0.000104379554117715 NA NA NA hsa-miR-335-3p SGCD 1.19503568251824 0.0938852560631551 -4.54262936780335 0.000169922663050445 mirMAP -0.294966964587087 0.0023242802700276 NA NA NA hsa-miR-339-5p SGCD 1.23326828594484 0.0307501214818698 -4.54262936780335 0.000169922663050445 PITA;miRNATAP -0.428471526963512 0.000396435545613688 NA NA NA hsa-miR-33a-3p SGCD 2.06269680799532 0.00156436055383943 -4.54262936780335 0.000169922663050445 mirMAP -0.275563538584386 0.00945290022886058 NA NA NA hsa-miR-33a-5p SGCD 2.60046838991599 0.000472459723448608 -4.54262936780335 0.000169922663050445 mirMAP;miRNATAP -0.306319573739299 0.00086999750542243 NA NA NA hsa-miR-33b-5p SGCD 4.77891217497671 1.33695107675057e-08 -4.54262936780335 0.000169922663050445 mirMAP;miRNATAP -0.41557267533463 1.59359420583333e-07 NA NA NA hsa-miR-3682-3p SGCD 1.83244576389151 0.0295200056820549 -4.54262936780335 0.000169922663050445 mirMAP -0.33471952390805 0.00100580268133727 NA NA NA hsa-miR-486-5p SGCD 1.10898145177457 0.309287974401609 -4.54262936780335 0.000169922663050445 miRanda -0.176634951976296 0.00525337179909551 NA NA NA hsa-miR-576-5p SGCD 1.30320223793746 0.00648929463912994 -4.54262936780335 0.000169922663050445 mirMAP -0.482497245105123 0.000852315633463426 NA NA NA hsa-miR-590-3p SGCD 2.35429565068338 2.79601879608564e-06 -4.54262936780335 0.000169922663050445 PITA;miRanda;mirMAP;miRNATAP -0.521988662002096 0.000118848937289071 NA NA NA hsa-miR-590-5p SGCD 1.51400888103768 0.0023888567923017 -4.54262936780335 0.000169922663050445 miRanda -0.397093600417576 0.004255970142178 NA NA NA hsa-miR-625-3p SGCD 1.75291360644906 0.000840901646169228 -4.54262936780335 0.000169922663050445 mirMAP -0.419393294249568 0.00140464729246074 NA NA NA hsa-miR-7-1-3p SGCD 1.43074343339835 0.00471215970502094 -4.54262936780335 0.000169922663050445 mirMAP -0.374097927327024 0.00630216797119466 NA NA NA hsa-miR-92a-3p SGCD 1.87892405805529 1.27013821556583e-05 -4.54262936780335 0.000169922663050445 mirMAP -0.722500960755591 5.28003676816514e-06 NA NA NA hsa-miR-93-5p SGCD 2.65964181833033 2.58315947526774e-08 -4.54262936780335 0.000169922663050445 mirMAP -0.482259061391534 0.000695228726469533 NA NA NA hsa-miR-944 SGCD 7.20925181386398 0.000823207457340648 -4.54262936780335 0.000169922663050445 PITA;mirMAP;miRNATAP -0.197060001695371 4.28378962613953e-07 NA NA NA hsa-miR-218-5p SLC6A8 -1.62589026509455 0.0400573414088521 1.53996100277543 0.0639294878033331 mirMAP -0.271267473343423 3.91511707116574e-06 NA NA NA hsa-miR-330-3p SLIT2 2.49094236945806 0.000129367003214715 -4.93618021188036 0.00112564600494852 miRNAWalker2_validate -0.477816298416439 0.000286709662491978 NA NA NA hsa-miR-590-3p SLIT2 2.35429565068338 2.79601879608564e-06 -4.93618021188036 0.00112564600494852 miRanda -0.657938476849425 0.000105293665021347 NA NA NA hsa-miR-148b-5p SLIT3 2.80812018666078 3.97536665756679e-08 -4.87157876816472 5.96920796738484e-06 mirMAP -0.35076545486386 0.00326691636714068 NA NA NA hsa-miR-16-2-3p SLIT3 3.79845098071094 1.49120139344659e-13 -4.87157876816472 5.96920796738484e-06 mirMAP -0.861426991692406 1.07983888270288e-14 NA NA NA hsa-miR-1976 SLIT3 3.27217274919653 3.16337235854532e-12 -4.87157876816472 5.96920796738484e-06 mirMAP -0.575361124341843 5.71282483583687e-06 NA NA NA hsa-miR-200c-5p SLIT3 5.34093243595571 3.35355119348069e-10 -4.87157876816472 5.96920796738484e-06 mirMAP -0.565591817896793 1.71088458687077e-11 NA NA NA hsa-miR-224-3p SLIT3 2.84876340814503 0.000179138399939161 -4.87157876816472 5.96920796738484e-06 mirMAP -0.312741431689791 0.000109079670710653 NA NA NA hsa-miR-330-3p SLIT3 2.49094236945806 0.000129367003214715 -4.87157876816472 5.96920796738484e-06 mirMAP -0.324284785626498 0.000588473256800094 NA NA NA hsa-miR-330-5p SLIT3 2.25110496739954 0.000275527655397415 -4.87157876816472 5.96920796738484e-06 miRanda;mirMAP -0.391819771125721 7.28202893503161e-05 NA NA NA hsa-miR-33a-3p SLIT3 2.06269680799532 0.00156436055383943 -4.87157876816472 5.96920796738484e-06 mirMAP -0.365317987671065 0.000109013364679016 NA NA NA hsa-miR-3682-3p SLIT3 1.83244576389151 0.0295200056820549 -4.87157876816472 5.96920796738484e-06 mirMAP -0.300636620051393 0.000965167999964592 NA NA NA hsa-miR-429 SLIT3 6.39965293994036 1.96920201593608e-18 -4.87157876816472 5.96920796738484e-06 miRNATAP -0.247572501620833 0.00191554990004349 NA NA NA hsa-miR-454-3p SLIT3 1.40269869979902 0.00366085847011367 -4.87157876816472 5.96920796738484e-06 mirMAP -0.376027409446061 0.0034470559327453 NA NA NA hsa-miR-550a-3p SLIT3 2.59872127213466 0.00155498164206068 -4.87157876816472 5.96920796738484e-06 mirMAP -0.500573999534092 3.00133002213759e-08 NA NA NA hsa-miR-590-3p SLIT3 2.35429565068338 2.79601879608564e-06 -4.87157876816472 5.96920796738484e-06 miRanda;mirMAP -0.407152496571392 0.00082618739130833 NA NA NA hsa-miR-590-5p SLIT3 1.51400888103768 0.0023888567923017 -4.87157876816472 5.96920796738484e-06 miRanda -0.321707463873107 0.00976064547700027 NA NA NA hsa-miR-96-5p SLIT3 5.62521466029286 1.54938806718028e-10 -4.87157876816472 5.96920796738484e-06 TargetScan -0.243966768028899 0.00352953672811676 NA NA NA hsa-miR-107 SNAI2 1.49443409571439 0.000130594521065411 -1.63105031719645 0.151947151729511 miRanda -0.697492767535727 2.28747541234486e-05 NA NA NA hsa-miR-148b-3p SNAI2 1.75622244535669 8.84414356040579e-08 -1.63105031719645 0.151947151729511 miRNAWalker2_validate -1.20416541853834 3.64181808017381e-10 NA NA NA hsa-miR-182-5p SNAI2 5.86988712704738 1.22411588571584e-15 -1.63105031719645 0.151947151729511 miRNAWalker2_validate;miRNATAP -0.350535353498724 2.46839505266114e-05 NA NA NA hsa-miR-200b-3p SNAI2 5.56167217794639 6.43540045061709e-16 -1.63105031719645 0.151947151729511 TargetScan -0.649397403907546 3.78497809111695e-14 NA NA NA hsa-miR-200c-3p SNAI2 6.47012025883743 2.64500707716408e-26 -1.63105031719645 0.151947151729511 miRNATAP -0.366231228387546 0.000154734539121361 NA NA NA hsa-miR-375 SNAI2 3.3784490463318 0.0449946294355695 -1.63105031719645 0.151947151729511 miRanda -0.405761563211418 3.15055753376226e-32 NA NA NA hsa-miR-429 SNAI2 6.39965293994036 1.96920201593608e-18 -1.63105031719645 0.151947151729511 PITA;miRanda;miRNATAP -0.555621837620757 5.73431212612017e-12 NA NA NA hsa-miR-532-5p SNAI2 -0.297424983759107 0.503934707453099 -1.63105031719645 0.151947151729511 PITA -0.961387727223608 1.45748468588014e-11 NA NA NA hsa-miR-96-5p SNAI2 5.62521466029286 1.54938806718028e-10 -1.63105031719645 0.151947151729511 miRNATAP -0.459083416473505 8.67842804706358e-08 NA NA NA hsa-miR-16-2-3p SNTB1 3.79845098071094 1.49120139344659e-13 -0.868927807592812 0.316425657480102 mirMAP -0.309932160176975 0.000744233538828849 NA NA NA hsa-miR-21-3p SNTB1 3.50297439576639 6.39946844099206e-10 -0.868927807592812 0.316425657480102 mirMAP -0.358403064487645 1.9001874416882e-05 NA NA NA hsa-miR-24-3p SNTB1 1.55853749533999 0.000524726461381821 -0.868927807592812 0.316425657480102 miRNAWalker2_validate -0.427475510489622 8.57391012279594e-05 NA NA NA hsa-miR-330-5p SNTB1 2.25110496739954 0.000275527655397415 -0.868927807592812 0.316425657480102 miRanda -0.236171440021274 0.00271913604929864 NA NA NA hsa-miR-33a-3p SNTB1 2.06269680799532 0.00156436055383943 -0.868927807592812 0.316425657480102 MirTarget -0.253329559911142 0.000743726807563019 NA NA NA hsa-miR-192-5p SPARC 1.77716187978541 0.113485496183047 -2.52454108356812 0.000994627806479441 miRNAWalker2_validate -0.101433503860639 0.00906611606539543 NA NA NA hsa-miR-19a-3p SPARC 2.17020503944519 0.00122084653711062 -2.52454108356812 0.000994627806479441 mirMAP -0.184326310678126 0.00447782172753251 NA NA NA hsa-miR-203a-3p SPARC 6.35084246337388 7.89944323347948e-08 -2.52454108356812 0.000994627806479441 MirTarget -0.145058641275739 5.19467214094249e-05 NA NA NA hsa-miR-224-3p SPARC 2.84876340814503 0.000179138399939161 -2.52454108356812 0.000994627806479441 mirMAP -0.16730484432619 0.0035745815734904 NA NA NA hsa-miR-29b-3p SPARC 0.666547117072858 0.234055379278093 -2.52454108356812 0.000994627806479441 miRNATAP -0.215642106203313 0.00604004506979079 NA NA NA hsa-miR-29c-3p SPARC -0.414153610337085 0.529344128062017 -2.52454108356812 0.000994627806479441 miRNAWalker2_validate;miRTarBase;miRNATAP -0.199066790347007 0.00280198874742414 NA NA NA hsa-miR-3065-5p SPARC 2.14185373842821 0.0609400502269891 -2.52454108356812 0.000994627806479441 mirMAP -0.189018991919507 6.401984359977e-05 NA NA NA hsa-miR-31-5p SPARC 7.15600983164746 6.64190917357724e-10 -2.52454108356812 0.000994627806479441 MirTarget -0.109732855025948 0.00266911559247166 NA NA NA hsa-miR-345-5p SPARC 2.77314563304336 4.34343702412489e-05 -2.52454108356812 0.000994627806479441 MirTarget -0.206079045570327 0.00121638228822108 NA NA NA hsa-miR-592 SPARC 2.80403350008555 0.0293520213681333 -2.52454108356812 0.000994627806479441 MirTarget -0.136161336015904 0.00104666588218675 NA NA NA hsa-miR-625-5p SPARC 2.02792641909347 0.000935142379948297 -2.52454108356812 0.000994627806479441 MirTarget -0.195479986661871 0.00640861358687655 NA NA NA hsa-let-7f-1-3p SPOCK1 1.61507869803314 0.00069342464777815 -3.14469859711893 0.0072981104184964 mirMAP -0.495871067140023 0.000413866536479065 NA NA NA hsa-miR-16-1-3p SPOCK1 2.83281226969693 7.54359864580834e-09 -3.14469859711893 0.0072981104184964 MirTarget -0.834317096692843 1.47074280228024e-10 NA NA NA hsa-miR-19a-3p SPOCK1 2.17020503944519 0.00122084653711062 -3.14469859711893 0.0072981104184964 MirTarget -0.327453366133607 0.000903209557241343 NA NA NA hsa-miR-19b-3p SPOCK1 1.67581705793313 0.000858910586302716 -3.14469859711893 0.0072981104184964 MirTarget -0.500615122155313 0.000148697393669768 NA NA NA hsa-miR-21-5p SPOCK1 2.65163477806992 6.72089787690756e-16 -3.14469859711893 0.0072981104184964 MirTarget -0.596817766125623 0.00250096401613531 NA NA NA hsa-miR-2110 SPOCK1 1.8070969695103 0.00137196847440523 -3.14469859711893 0.0072981104184964 MirTarget -0.361929873354218 0.00264022018857604 NA NA NA hsa-miR-23a-5p SPOCK1 2.86720096840797 0.000290788677230784 -3.14469859711893 0.0072981104184964 MirTarget -0.271143617298916 0.00114214817573139 NA NA NA hsa-miR-33a-3p SPOCK1 2.06269680799532 0.00156436055383943 -3.14469859711893 0.0072981104184964 mirMAP -0.266422205530606 0.00929728216897515 NA NA NA hsa-miR-429 SPOCK1 6.39965293994036 1.96920201593608e-18 -3.14469859711893 0.0072981104184964 miRNATAP -0.255210195923188 0.00301904953229357 NA NA NA hsa-miR-454-3p SPOCK1 1.40269869979902 0.00366085847011367 -3.14469859711893 0.0072981104184964 MirTarget -0.44652648213396 0.00124995504946733 NA NA NA hsa-miR-590-3p SPOCK1 2.35429565068338 2.79601879608564e-06 -3.14469859711893 0.0072981104184964 PITA;miRanda;mirMAP -0.499743817909606 0.000134282324061545 NA NA NA hsa-miR-590-5p SPOCK1 1.51400888103768 0.0023888567923017 -3.14469859711893 0.0072981104184964 MirTarget;miRanda;mirMAP -0.360404208078741 0.00720545371305413 NA NA NA hsa-miR-629-3p SPOCK1 3.48282157979573 4.9176538695908e-08 -3.14469859711893 0.0072981104184964 MirTarget -0.267592229423552 0.00904418857878737 NA NA NA hsa-miR-335-5p SPP1 0.167216045757305 0.803897055331049 2.62378012379966 0.0238129713516633 miRNAWalker2_validate -0.267186283709632 0.00657323488702888 NA NA NA hsa-miR-362-3p SPP1 0.679952485897744 0.226148468488576 2.62378012379966 0.0238129713516633 miRanda -0.392073615184002 0.000902670978383756 NA NA NA hsa-miR-542-3p SPP1 -0.376147863244659 0.438002751207043 2.62378012379966 0.0238129713516633 miRanda -0.410980003553363 0.00273549957767339 NA NA NA hsa-miR-128-3p TAGLN 1.36248409467631 0.00408435995818078 -6.20907671203866 8.78464384400634e-11 miRNAWalker2_validate -0.504972294816383 1.7223992454665e-05 NA NA NA hsa-miR-625-5p TAGLN 2.02792641909347 0.000935142379948297 -6.20907671203866 8.78464384400634e-11 mirMAP -0.245952393053767 0.00739808574071397 NA NA NA hsa-miR-7-5p TAGLN 3.59831747997243 0.000676336260217879 -6.20907671203866 8.78464384400634e-11 miRNAWalker2_validate -0.223822071007383 0.000523960936363371 NA NA NA hsa-miR-23b-3p TFPI2 -0.581135273821923 0.190478897170459 -2.90314147661801 0.141958300611285 MirTarget;miRNATAP -1.1610093851756 4.32337205210587e-06 NA NA NA hsa-miR-944 TFPI2 7.20925181386398 0.000823207457340648 -2.90314147661801 0.141958300611285 mirMAP -0.226768570308501 0.00038254181680952 NA NA NA hsa-miR-362-3p TGFBI 0.679952485897744 0.226148468488576 0.811409132600236 0.396742917873662 miRanda -0.356737847878306 0.000230264157392837 NA NA NA hsa-miR-429 TGFBI 6.39965293994036 1.96920201593608e-18 0.811409132600236 0.396742917873662 miRanda -0.320823274439743 3.54094919863446e-06 NA NA NA hsa-miR-15a-5p TGFBR3 2.0535411006904 1.91108976398046e-06 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.398252051497784 0.000579622324303971 NA NA NA hsa-miR-15b-5p TGFBR3 3.32329949959268 8.40210501034588e-13 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.308598579670601 0.00329766225446434 NA NA NA hsa-miR-16-2-3p TGFBR3 3.79845098071094 1.49120139344659e-13 -4.8172798831592 2.83698243439907e-08 mirMAP -0.510816849440913 3.63317831108554e-08 NA NA NA hsa-miR-16-5p TGFBR3 2.93575808220754 2.15436817162977e-10 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.398826844441648 0.000167618497525506 NA NA NA hsa-miR-18a-3p TGFBR3 3.64944956993027 7.20156641833731e-07 -4.8172798831592 2.83698243439907e-08 MirTarget -0.276229137548183 3.81281614466793e-05 NA NA NA hsa-miR-18a-5p TGFBR3 3.90770175770219 9.15298615034137e-10 -4.8172798831592 2.83698243439907e-08 MirTarget -0.313514148171929 3.94123087172394e-05 NA NA NA hsa-miR-21-5p TGFBR3 2.65163477806992 6.72089787690756e-16 -4.8172798831592 2.83698243439907e-08 miRNAWalker2_validate -0.67212333147917 5.19481182016835e-06 NA NA NA hsa-miR-222-5p TGFBR3 2.52056758362407 0.00142010793166944 -4.8172798831592 2.83698243439907e-08 MirTarget -0.352823463780761 1.35483244347225e-08 NA NA NA hsa-miR-27a-3p TGFBR3 1.76094007417453 0.000216137556256765 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.352585790116035 0.000816843585172177 NA NA NA hsa-miR-27b-3p TGFBR3 -0.0929089601968123 0.85847352206581 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.287369611968484 0.00313932913796485 NA NA NA hsa-miR-33a-3p TGFBR3 2.06269680799532 0.00156436055383943 -4.8172798831592 2.83698243439907e-08 mirMAP -0.24065182722194 0.00179364317738789 NA NA NA hsa-miR-484 TGFBR3 1.79050445056016 0.000217287101253701 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.315397888660127 0.00235031958258578 NA NA NA hsa-miR-590-3p TGFBR3 2.35429565068338 2.79601879608564e-06 -4.8172798831592 2.83698243439907e-08 MirTarget;miRanda;mirMAP -0.285337459789671 0.00402891046812002 NA NA NA hsa-miR-627-5p TGFBR3 1.68461263902065 0.00697075274507733 -4.8172798831592 2.83698243439907e-08 MirTarget -0.254442023518234 0.0016844231918282 NA NA NA hsa-miR-944 TGFBR3 7.20925181386398 0.000823207457340648 -4.8172798831592 2.83698243439907e-08 mirMAP -0.130912091086309 4.23191284323791e-06 NA NA NA hsa-miR-106a-5p TGM2 3.98693608217557 9.37722470816656e-07 -3.1811826378625 0.00352731383378931 MirTarget -0.301544002010539 5.2001156420795e-05 NA NA NA hsa-miR-106b-5p TGM2 2.80565545918114 1.14547999022566e-09 -3.1811826378625 0.00352731383378931 MirTarget -0.6435182857967 8.22271104435605e-07 NA NA NA hsa-miR-17-5p TGM2 2.3269271449522 2.13987445663942e-05 -3.1811826378625 0.00352731383378931 MirTarget -0.437610902385121 9.21014628034583e-05 NA NA NA hsa-miR-20a-5p TGM2 2.13553469875764 0.000181201072324354 -3.1811826378625 0.00352731383378931 MirTarget -0.44789125506609 3.09620333530806e-05 NA NA NA hsa-miR-20b-5p TGM2 4.5662923200279 4.75238200639144e-05 -3.1811826378625 0.00352731383378931 MirTarget -0.183703825475406 0.000730667492119932 NA NA NA hsa-miR-324-3p TGM2 1.51345381556672 0.0038447546677657 -3.1811826378625 0.00352731383378931 MirTarget -0.394279641783353 0.000874977970163366 NA NA NA hsa-miR-93-5p TGM2 2.65964181833033 2.58315947526774e-08 -3.1811826378625 0.00352731383378931 MirTarget -0.766437736028038 8.94518592348684e-10 NA NA NA hsa-let-7a-5p THBS1 0.148081801547773 0.645305441523746 -3.75129916683394 0.000103499881096753 miRNAWalker2_validate;TargetScan -0.497243904586914 0.00492292853577542 NA NA NA hsa-miR-16-1-3p THBS1 2.83281226969693 7.54359864580834e-09 -3.75129916683394 0.000103499881096753 MirTarget -0.643028399066049 3.09438933664662e-09 NA NA NA hsa-miR-17-5p THBS1 2.3269271449522 2.13987445663942e-05 -3.75129916683394 0.000103499881096753 miRNAWalker2_validate -0.267945077391595 0.00757970547802144 NA NA NA hsa-miR-182-5p THBS1 5.86988712704738 1.22411588571584e-15 -3.75129916683394 0.000103499881096753 MirTarget -0.241099584124763 0.000765040193303936 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-186-5p THBS1 0.445443449112564 0.185447310527704 -3.75129916683394 0.000103499881096753 mirMAP -0.462978112860335 0.00599316633809753 NA NA NA hsa-miR-19b-3p THBS1 1.67581705793313 0.000858910586302716 -3.75129916683394 0.000103499881096753 MirTarget;mirMAP -0.333448340944079 0.00241856130914615 NA NA NA hsa-miR-200a-5p THBS1 6.52092140839401 5.73108242597059e-22 -3.75129916683394 0.000103499881096753 MirTarget -0.485719624657622 5.54901388898712e-11 NA NA NA hsa-miR-200b-5p THBS1 6.81954246537908 6.31100593281326e-24 -3.75129916683394 0.000103499881096753 MirTarget -0.501001329221048 9.13787343375865e-12 NA NA NA hsa-miR-20a-5p THBS1 2.13553469875764 0.000181201072324354 -3.75129916683394 0.000103499881096753 miRNAWalker2_validate -0.307672252327679 0.00140150807491854 NA NA NA hsa-miR-3065-5p THBS1 2.14185373842821 0.0609400502269891 -3.75129916683394 0.000103499881096753 MirTarget -0.227705987060518 0.000143233633612563 NA NA NA hsa-miR-33a-3p THBS1 2.06269680799532 0.00156436055383943 -3.75129916683394 0.000103499881096753 MirTarget;mirMAP -0.24999380439174 0.00320886077009575 NA NA NA hsa-miR-375 THBS1 3.3784490463318 0.0449946294355695 -3.75129916683394 0.000103499881096753 miRanda -0.104064726462059 0.00140403889155616 NA NA NA hsa-miR-500a-5p THBS1 0.0170829425378565 0.973960207660626 -3.75129916683394 0.000103499881096753 mirMAP -0.360122797705364 0.000716954259923395 NA NA NA hsa-miR-576-5p THBS1 1.30320223793746 0.00648929463912994 -3.75129916683394 0.000103499881096753 mirMAP -0.371752416748424 0.00133090246897115 NA NA NA hsa-miR-590-3p THBS1 2.35429565068338 2.79601879608564e-06 -3.75129916683394 0.000103499881096753 miRanda -0.305195275125083 0.00517237635189344 NA NA NA hsa-miR-616-5p THBS1 2.48416313933027 0.00318247475868827 -3.75129916683394 0.000103499881096753 mirMAP -0.253411231221945 0.00197529844240196 NA NA NA hsa-miR-106a-5p THBS2 3.98693608217557 9.37722470816656e-07 -2.62795619060355 0.00635907547670508 MirTarget -0.336063474905193 2.56551669416365e-07 NA NA NA hsa-miR-106b-5p THBS2 2.80565545918114 1.14547999022566e-09 -2.62795619060355 0.00635907547670508 MirTarget -0.754072944240837 2.88430240077148e-11 NA NA NA hsa-miR-142-5p THBS2 3.95552531913424 1.49536283724079e-08 -2.62795619060355 0.00635907547670508 mirMAP -0.208949988681772 0.00645371511907511 NA NA NA hsa-miR-16-2-3p THBS2 3.79845098071094 1.49120139344659e-13 -2.62795619060355 0.00635907547670508 mirMAP -0.678064085425023 1.06849736981054e-11 NA NA NA hsa-miR-17-5p THBS2 2.3269271449522 2.13987445663942e-05 -2.62795619060355 0.00635907547670508 MirTarget;TargetScan -0.460832414079987 2.70142073659636e-06 NA NA NA hsa-miR-182-5p THBS2 5.86988712704738 1.22411588571584e-15 -2.62795619060355 0.00635907547670508 MirTarget;miRNATAP -0.185107388497314 0.00936294018881331 NA NA NA hsa-miR-20a-5p THBS2 2.13553469875764 0.000181201072324354 -2.62795619060355 0.00635907547670508 MirTarget -0.415858722079042 1.12986282215266e-05 NA NA NA hsa-miR-20b-5p THBS2 4.5662923200279 4.75238200639144e-05 -2.62795619060355 0.00635907547670508 MirTarget -0.199742215607688 2.8796635402953e-05 NA NA NA hsa-miR-32-3p THBS2 2.20477794939766 0.0392771274032852 -2.62795619060355 0.00635907547670508 miRNATAP -0.311183273683396 0.000549233998665121 NA NA NA hsa-miR-335-3p THBS2 1.19503568251824 0.0938852560631551 -2.62795619060355 0.00635907547670508 MirTarget;mirMAP -0.238234138626814 0.00191001264899203 NA NA NA hsa-miR-3614-5p THBS2 4.50236405439456 2.75644515847367e-07 -2.62795619060355 0.00635907547670508 miRNATAP -0.20657913597438 0.000767513919935484 NA NA NA hsa-miR-590-3p THBS2 2.35429565068338 2.79601879608564e-06 -2.62795619060355 0.00635907547670508 miRanda;mirMAP -0.366044680216134 0.000684664156327022 NA NA NA hsa-miR-590-5p THBS2 1.51400888103768 0.0023888567923017 -2.62795619060355 0.00635907547670508 miRanda -0.401872758797421 0.000247068390424525 NA NA NA hsa-miR-93-5p THBS2 2.65964181833033 2.58315947526774e-08 -2.62795619060355 0.00635907547670508 MirTarget -0.540936215734632 1.26073372180003e-06 NA NA NA hsa-miR-96-5p THBS2 5.62521466029286 1.54938806718028e-10 -2.62795619060355 0.00635907547670508 TargetScan;miRNATAP -0.298099877132397 5.09583790054224e-05 NA NA NA hsa-miR-330-3p THY1 2.49094236945806 0.000129367003214715 -1.74655793636875 0.0385463492110154 mirMAP -0.212194435180142 0.00376392444050638 NA NA NA hsa-miR-423-5p THY1 0.227366878624794 0.5653498335202 -1.74655793636875 0.0385463492110154 MirTarget -0.396605321325712 0.0012546604517008 NA NA NA hsa-miR-106a-5p TIMP3 3.98693608217557 9.37722470816656e-07 -4.5244412907566 3.61006423790288e-06 miRNATAP -0.457603671547648 3.34961801580846e-12 NA NA NA hsa-miR-106b-5p TIMP3 2.80565545918114 1.14547999022566e-09 -4.5244412907566 3.61006423790288e-06 miRNATAP -0.683923114467903 5.3734627495312e-09 NA NA NA hsa-miR-148a-5p TIMP3 1.31769244477686 0.0507400532963856 -4.5244412907566 3.61006423790288e-06 mirMAP -0.226145938470784 0.00669905243421921 NA NA NA hsa-miR-16-1-3p TIMP3 2.83281226969693 7.54359864580834e-09 -4.5244412907566 3.61006423790288e-06 mirMAP -0.450389447952854 5.7186823730764e-05 NA NA NA hsa-miR-16-5p TIMP3 2.93575808220754 2.15436817162977e-10 -4.5244412907566 3.61006423790288e-06 miRNAWalker2_validate -0.587746027823544 5.50068500929668e-07 NA NA NA hsa-miR-188-5p TIMP3 1.39111178824125 0.0251592818948912 -4.5244412907566 3.61006423790288e-06 mirMAP -0.385418280272307 1.93316983974164e-05 NA NA NA hsa-miR-3065-5p TIMP3 2.14185373842821 0.0609400502269891 -4.5244412907566 3.61006423790288e-06 MirTarget;miRNATAP -0.222213891988497 0.000263085520503919 NA NA NA hsa-miR-32-3p TIMP3 2.20477794939766 0.0392771274032852 -4.5244412907566 3.61006423790288e-06 mirMAP;miRNATAP -0.2447841760683 0.00829857030971089 NA NA NA hsa-miR-3200-3p TIMP3 2.3251191657063 0.0140310042534957 -4.5244412907566 3.61006423790288e-06 mirMAP -0.185315711743899 0.00187176206358414 NA NA NA hsa-miR-3607-3p TIMP3 1.38015131722213 0.0240067155694847 -4.5244412907566 3.61006423790288e-06 MirTarget;miRNATAP -0.248760013544865 0.00687837173132934 NA NA NA hsa-miR-362-3p TIMP3 0.679952485897744 0.226148468488576 -4.5244412907566 3.61006423790288e-06 miRanda -0.452251892590365 5.98391179361376e-06 NA NA NA hsa-miR-423-5p TIMP3 0.227366878624794 0.5653498335202 -4.5244412907566 3.61006423790288e-06 miRNAWalker2_validate -0.519982450896257 0.000303187311273849 NA NA NA hsa-miR-590-3p TIMP3 2.35429565068338 2.79601879608564e-06 -4.5244412907566 3.61006423790288e-06 PITA;miRanda;miRNATAP -0.476750806655718 1.43958503266671e-05 NA NA NA hsa-miR-590-5p TIMP3 1.51400888103768 0.0023888567923017 -4.5244412907566 3.61006423790288e-06 MirTarget;PITA;miRanda;miRNATAP -0.355251483360423 0.00163145397080864 NA NA NA hsa-miR-660-5p TIMP3 -0.0668683798854808 0.885250178390404 -4.5244412907566 3.61006423790288e-06 miRNATAP -0.430441966301782 0.000430118903182918 NA NA NA hsa-miR-7-1-3p TIMP3 1.43074343339835 0.00471215970502094 -4.5244412907566 3.61006423790288e-06 mirMAP -0.466289895814414 2.40453293846502e-05 NA NA NA hsa-miR-141-3p TNFAIP3 7.30474126597325 1.45115996357606e-24 -0.227857867110596 0.722881073828263 TargetScan -0.122001620410365 0.00945105981805664 NA NA NA hsa-miR-362-3p TNFAIP3 0.679952485897744 0.226148468488576 -0.227857867110596 0.722881073828263 miRanda -0.174234848247989 0.00757660477501398 NA NA NA hsa-miR-429 TNFAIP3 6.39965293994036 1.96920201593608e-18 -0.227857867110596 0.722881073828263 miRanda -0.216051632763113 3.16080366217576e-06 NA NA NA hsa-miR-616-5p TNFAIP3 2.48416313933027 0.00318247475868827 -0.227857867110596 0.722881073828263 mirMAP -0.141210714737081 0.00877195410304834 NA NA NA hsa-miR-142-3p TNFRSF11B 4.35304505457969 3.10014573651358e-10 -1.46701364348978 0.262895969157481 miRanda -0.411795739941902 7.0503611806867e-05 NA NA NA hsa-miR-34c-5p TNFRSF11B 2.64675661251039 0.0157394735757952 -1.46701364348978 0.262895969157481 miRanda -0.214418209313792 0.00144830408533598 NA NA NA hsa-miR-590-3p TNFRSF11B 2.35429565068338 2.79601879608564e-06 -1.46701364348978 0.262895969157481 miRanda -0.641712619326697 9.66375857404103e-06 NA NA NA hsa-miR-590-5p TNFRSF11B 1.51400888103768 0.0023888567923017 -1.46701364348978 0.262895969157481 PITA;miRanda;miRNATAP -0.441160960388167 0.00307690109490345 NA NA NA hsa-miR-142-3p TPM1 4.35304505457969 3.10014573651358e-10 -3.85847267907588 1.11233400104492e-06 miRanda -0.332162115355654 1.42918036863779e-07 NA NA NA hsa-miR-146b-5p TPM1 1.87569569182453 0.000737241069698886 -3.85847267907588 1.11233400104492e-06 miRanda -0.411786043257618 3.4287893722964e-07 NA NA NA hsa-miR-33a-3p TPM1 2.06269680799532 0.00156436055383943 -3.85847267907588 1.11233400104492e-06 miRNATAP -0.198707728884241 0.00455538078116967 NA NA NA hsa-miR-429 TPM1 6.39965293994036 1.96920201593608e-18 -3.85847267907588 1.11233400104492e-06 miRNATAP -0.185304387701649 0.00163955405179415 NA NA NA hsa-miR-590-3p TPM1 2.35429565068338 2.79601879608564e-06 -3.85847267907588 1.11233400104492e-06 miRanda -0.269596038394302 0.00273800938866907 NA NA NA hsa-miR-944 TPM1 7.20925181386398 0.000823207457340648 -3.85847267907588 1.11233400104492e-06 mirMAP -0.172504072597155 9.42640702609591e-12 NA NA NA hsa-miR-15a-5p TPM2 2.0535411006904 1.91108976398046e-06 -4.41920599687158 4.0638739076821e-08 MirTarget -0.302767476109933 0.00492118230672681 NA NA NA hsa-miR-16-5p TPM2 2.93575808220754 2.15436817162977e-10 -4.41920599687158 4.0638739076821e-08 MirTarget -0.324447272515291 0.000992017919120022 NA NA NA hsa-miR-185-5p TPM2 2.46768243458192 6.53179875424217e-08 -4.41920599687158 4.0638739076821e-08 MirTarget -0.557655673623177 1.77761962215623e-08 NA NA NA hsa-miR-125a-5p TPM4 -1.32352790615388 0.00714301627309467 -0.583104367154878 0.146603438771301 miRNAWalker2_validate -0.135527421362761 0.00338231742914297 NA NA NA hsa-miR-28-5p TPM4 -0.815636722979196 0.0221199948901761 -0.583104367154878 0.146603438771301 miRNAWalker2_validate -0.253588286711043 8.14146247387033e-05 NA NA NA hsa-miR-30c-5p TPM4 0.38723991118075 0.348605235643473 -0.583104367154878 0.146603438771301 miRNATAP -0.249453052534605 6.06648716741612e-06 NA NA NA hsa-miR-339-5p TPM4 1.23326828594484 0.0307501214818698 -0.583104367154878 0.146603438771301 miRanda -0.178610953998272 5.86977608760562e-06 NA NA NA hsa-let-7f-1-3p VCAM1 1.61507869803314 0.00069342464777815 -1.53361282607347 0.132965096563532 MirTarget -0.424803951844466 0.000487811731774545 NA NA NA hsa-miR-200a-3p VCAM1 6.336081120041 4.024313571871e-16 -1.53361282607347 0.132965096563532 miRNAWalker2_validate -0.237886699290587 0.000728103222771694 NA NA NA hsa-miR-590-5p VCAM1 1.51400888103768 0.0023888567923017 -1.53361282607347 0.132965096563532 miRanda -0.451609146925376 9.29539860095349e-05 NA NA NA hsa-let-7f-1-3p VCAN 1.61507869803314 0.00069342464777815 -0.93481074618867 0.393275413305526 MirTarget -0.525452322405872 5.36711351634967e-05 NA NA NA hsa-let-7f-2-3p VCAN 1.02768112108475 0.0787293499732611 -0.93481074618867 0.393275413305526 MirTarget -0.286021522717963 0.00869391808247874 NA NA NA hsa-miR-141-3p VCAN 7.30474126597325 1.45115996357606e-24 -0.93481074618867 0.393275413305526 MirTarget;TargetScan;miRNATAP -0.439449051470199 2.32198943558733e-08 NA NA NA hsa-miR-16-2-3p VCAN 3.79845098071094 1.49120139344659e-13 -0.93481074618867 0.393275413305526 mirMAP -0.772998649893569 7.11173506771193e-12 NA NA NA hsa-miR-200a-3p VCAN 6.336081120041 4.024313571871e-16 -0.93481074618867 0.393275413305526 MirTarget;miRNATAP -0.338711454057603 6.11427016106795e-06 NA NA NA hsa-miR-203a-3p VCAN 6.35084246337388 7.89944323347948e-08 -0.93481074618867 0.393275413305526 MirTarget -0.15871018524394 0.00188789465606068 NA NA NA hsa-miR-335-3p VCAN 1.19503568251824 0.0938852560631551 -0.93481074618867 0.393275413305526 MirTarget -0.232820933447767 0.00743701915789527 NA NA NA hsa-miR-33a-3p VCAN 2.06269680799532 0.00156436055383943 -0.93481074618867 0.393275413305526 mirMAP -0.33073341285765 0.000483423440580956 NA NA NA hsa-miR-33a-5p VCAN 2.60046838991599 0.000472459723448608 -0.93481074618867 0.393275413305526 MirTarget -0.327451639566504 6.73249959925658e-05 NA NA NA hsa-miR-33b-5p VCAN 4.77891217497671 1.33695107675057e-08 -0.93481074618867 0.393275413305526 MirTarget -0.360492712192067 4.10221210717953e-07 NA NA NA hsa-miR-361-3p VCAN 0.805698609170807 0.0418491665498322 -0.93481074618867 0.393275413305526 miRNATAP -0.661686026088568 2.64209233160283e-05 NA NA NA hsa-miR-429 VCAN 6.39965293994036 1.96920201593608e-18 -0.93481074618867 0.393275413305526 miRanda -0.29624695967173 0.000199339224784279 NA NA NA hsa-miR-590-3p VCAN 2.35429565068338 2.79601879608564e-06 -0.93481074618867 0.393275413305526 miRanda -0.333160611356228 0.00645954143592997 NA NA NA hsa-miR-101-3p VEGFA -1.12421603598195 0.0200907284788457 -0.606702191559893 0.316325541201332 miRNAWalker2_validate -0.44049017437003 2.14988554587478e-10 NA NA NA hsa-miR-140-5p VEGFA -0.634610285725923 0.126670572966239 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.25107167892515 0.00261330338296037 26402430 MicroRNA 140 5p inhibits the progression of colorectal cancer by targeting VEGFA; The direct regulation of VEGFA by miR-140-5p was identified using luciferase reporter assay; Integrated analysis identified VEGFA as a direct and functional target gene of miR-140-5p; Silencing VEGFA by small interfering RNA siRNA resembled the phenotype resulting from ectopic miR-140-5p expression while overexpression of VEGFA attenuated the effect of miR-140-5p on CRC cells; Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA progression;tumorigenesis colorectal cancer hsa-miR-145-5p VEGFA -3.55505374822025 5.45525288912869e-07 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase -0.128423755259373 0.00677881518234136 24781864;24966896;22472569 Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically metastasis;; thyroid cancer;bladder cancer;sarcoma hsa-miR-150-5p VEGFA 1.76769157530064 0.0593795975117846 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase -0.190454559321715 1.05415152205695e-07 NA NA NA hsa-miR-195-5p VEGFA -1.59182537400701 0.0169128463756769 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase;MirTarget -0.181624543409355 0.000381561947949573 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199a-5p VEGFA -1.24888110793613 0.0747755616523728 -0.606702191559893 0.316325541201332 miRanda;miRNATAP -0.137846678781097 0.00478526288616186 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA -0.53728867775768 0.476885702455766 -0.606702191559893 0.316325541201332 miRanda -0.179432408970336 6.95568617152433e-05 NA NA NA hsa-miR-29a-3p VEGFA -0.638239697975974 0.251923581881716 -0.606702191559893 0.316325541201332 MirTarget -0.17079026405468 0.00573296636369365 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29b-2-5p VEGFA -0.596051745078872 0.189540844841389 -0.606702191559893 0.316325541201332 MirTarget -0.280821422267245 0.000211600516233879 NA NA NA hsa-miR-29b-3p VEGFA 0.666547117072858 0.234055379278093 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase;MirTarget -0.16053544503029 0.00905921871447091 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-29c-3p VEGFA -0.414153610337085 0.529344128062017 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;MirTarget -0.264648504422189 2.62132710063096e-07 NA NA NA hsa-miR-342-3p VEGFA 1.31107714473009 0.0207211910724662 -0.606702191559893 0.316325541201332 miRanda;miRNATAP -0.189890193502324 0.00167517321250592 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-497-5p VEGFA -1.44150596209372 0.0225146607606395 -0.606702191559893 0.316325541201332 MirTarget -0.20501977308518 0.000143045715274148 26718330;26485685;26336827;26202364;27015364;25176450;26840372 Furthermore western blot assay confirmed that the overexpression of miR-497 reduced VEGF and HIF-1α protein levels; Moreover miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model which was probably caused by the downregulation of pro-angiogenic molecules such as VEGF and HIF-1α;Role of miR 497 in VEGF A mediated cancer cell growth and invasion in non small cell lung cancer; Here we showed that compared to other cancers NSCLC had a significant higher ratio of VEGF-A protein vs mRNA and significantly lower levels of miR-497 suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers; Compared with paired normal lung tissue NSCLC expressed lower levels of miR-497 and higher levels of VEGF-A; Moreover the levels of miR-497 and VEGF-A were inversely correlated in NSCLC specimen; Bioinformatics analyses showed that miR-497 bound to 3'-UTR of VEGF-A mRNA in NSCLC lines to inhibit its translation; Overexpression of miR-497 in NSCLC lines decreased VEGF-A protein while depletion of miR-497 in NSCLC lines increased VEGF-A protein; However modification of miR-497 levels in NSCLC lines did not alter VEGF-A mRNA levels;MiR 497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG 1; Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions UTRs of vascular endothelial growth factor A VEGFA and astrocyte elevated gene-1 AEG-1;The effects of ectopic miR-497 expression on the expression of VEGFA Akt and p-Akt were determined by western blot; Luciferase reporter assay and western blot confirmed that VEGFA was a direct target of miR-497;Subsequent investigations disclosed that Twist was regulated by miR-497 directly leading to the increased level of Vascular Endothelial Growth Factor-A VEGFA;We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and in turn impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways;Vascular endothelial growth factor-A VEGF-A was confirmed to be a target of miR-497 ;;metastasis;;;; breast cancer;lung squamous cell cancer;liver cancer;sarcoma;pancreatic cancer;ovarian cancer;colorectal cancer hsa-miR-16-2-3p VEGFC 3.79845098071094 1.49120139344659e-13 -2.61199123014623 0.00786293959867815 MirTarget -0.523426860787708 4.20594096318382e-07 NA NA NA hsa-miR-16-5p VIM 2.93575808220754 2.15436817162977e-10 -3.15289022251249 1.92539585692352e-06 miRNAWalker2_validate -0.471812038464405 2.24504373474572e-09 NA NA NA hsa-miR-17-3p VIM 1.2477858204856 0.00186593270231258 -3.15289022251249 1.92539585692352e-06 miRNAWalker2_validate;miRNATAP -0.327710863958809 0.000603329180146913 19771525;23418359 The lack of miR-17-3p expression correlated with an increase in vimentin synthesis and tumorigenicity; Stable expression of miR-17-3p in the M12 subline reduced vimentin levels 85% and reverted growth to organized polarized acini in lrECM gels;In contrast the passenger strand miR-17-3p repressed expression of vimentin an intermediate filament with the ability to modulate metabolism and GalNT7 an enzyme that regulates metabolism of liver toxin galactosamine ; prostate cancer;liver cancer hsa-miR-590-3p VIM 2.35429565068338 2.79601879608564e-06 -3.15289022251249 1.92539585692352e-06 mirMAP -0.218970868962392 0.00357550701939726 NA NA NA hsa-miR-1266-5p WIPF1 2.85243622342966 0.00457354565504108 -1.3199372564298 0.0475876731819671 MirTarget -0.127423716175692 0.000635762811856459 NA NA NA hsa-miR-129-5p WIPF1 -2.66843722411409 0.00695783358331245 -1.3199372564298 0.0475876731819671 miRanda -0.112734744645819 0.00347579173251545 NA NA NA hsa-miR-141-3p WIPF1 7.30474126597325 1.45115996357606e-24 -1.3199372564298 0.0475876731819671 MirTarget;TargetScan;miRNATAP -0.223715680115683 3.66349812026041e-06 NA NA NA hsa-miR-182-5p WIPF1 5.86988712704738 1.22411588571584e-15 -1.3199372564298 0.0475876731819671 MirTarget;miRNATAP -0.239014274727245 7.91139647877543e-07 NA NA NA hsa-miR-200a-3p WIPF1 6.336081120041 4.024313571871e-16 -1.3199372564298 0.0475876731819671 MirTarget;miRNATAP -0.290539410838852 9.43803663685651e-11 NA NA NA hsa-miR-200b-3p WIPF1 5.56167217794639 6.43540045061709e-16 -1.3199372564298 0.0475876731819671 MirTarget;TargetScan -0.367903906798664 2.89360356929466e-13 NA NA NA hsa-miR-200c-3p WIPF1 6.47012025883743 2.64500707716408e-26 -1.3199372564298 0.0475876731819671 MirTarget;miRNATAP -0.270239604564852 1.57518771534792e-06 NA NA NA hsa-miR-26a-2-3p WIPF1 0.348140795080704 0.50914395378277 -1.3199372564298 0.0475876731819671 mirMAP -0.228494100601931 0.00154713696544082 NA NA NA hsa-miR-324-5p WIPF1 1.31253452379847 0.0116806680545163 -1.3199372564298 0.0475876731819671 miRanda -0.232863771763941 0.00135157157912984 NA NA NA hsa-miR-33a-3p WIPF1 2.06269680799532 0.00156436055383943 -1.3199372564298 0.0475876731819671 MirTarget -0.266447369401864 3.34571268776159e-06 NA NA NA hsa-miR-34c-5p WIPF1 2.64675661251039 0.0157394735757952 -1.3199372564298 0.0475876731819671 miRanda -0.110689888191843 0.0012341919261058 NA NA NA hsa-miR-361-5p WIPF1 0.00649167180664723 0.985202350239079 -1.3199372564298 0.0475876731819671 miRanda -0.285011700576012 0.00993678063788804 NA NA NA hsa-miR-378a-5p WIPF1 1.25775140086104 0.0500877723587615 -1.3199372564298 0.0475876731819671 MirTarget -0.344166123672543 2.3047066136941e-09 NA NA NA hsa-miR-429 WIPF1 6.39965293994036 1.96920201593608e-18 -1.3199372564298 0.0475876731819671 MirTarget;PITA;miRanda;miRNATAP -0.370172333356679 2.16368080598244e-15 NA NA NA hsa-miR-9-5p WIPF1 1.79620806707734 0.14526963042518 -1.3199372564298 0.0475876731819671 miRNATAP -0.13239727454404 1.2105762532108e-05 NA NA NA hsa-miR-96-5p WIPF1 5.62521466029286 1.54938806718028e-10 -1.3199372564298 0.0475876731819671 miRNATAP -0.284057150654358 1.41212392236912e-08 NA NA NA hsa-miR-141-3p WNT5A 7.30474126597325 1.45115996357606e-24 -0.335254267155151 0.714960765245992 TargetScan -0.185678372077036 0.00570301174175726 NA NA NA hsa-miR-15b-3p WNT5A 3.57530146629867 5.89922785773482e-11 -0.335254267155151 0.714960765245992 mirMAP -0.24311589972858 0.00863820879774156 NA NA NA hsa-miR-16-2-3p WNT5A 3.79845098071094 1.49120139344659e-13 -0.335254267155151 0.714960765245992 MirTarget;mirMAP -0.311764225567874 0.00135279684345927 NA NA NA hsa-miR-16-5p WNT5A 2.93575808220754 2.15436817162977e-10 -0.335254267155151 0.714960765245992 miRNAWalker2_validate -0.290441753916783 0.00829455186858816 NA NA NA hsa-miR-2110 WNT5A 1.8070969695103 0.00137196847440523 -0.335254267155151 0.714960765245992 MirTarget -0.30255767867938 0.00122728628679992 NA NA NA hsa-miR-30c-5p WNT5A 0.38723991118075 0.348605235643473 -0.335254267155151 0.714960765245992 mirMAP -0.369350346658232 0.00376556464462393 NA NA NA hsa-miR-30d-3p WNT5A -0.0740421896025512 0.857423650167556 -0.335254267155151 0.714960765245992 mirMAP -0.440328526023165 0.000555223243909098 NA NA NA hsa-miR-30d-5p WNT5A 0.302504510257496 0.380193536606962 -0.335254267155151 0.714960765245992 mirMAP -0.416582436731857 0.00691722632235903 NA NA NA hsa-miR-30e-5p WNT5A 0.780047227271616 0.0346714425913016 -0.335254267155151 0.714960765245992 mirMAP -0.392965061384389 0.00598951520393619 NA NA NA hsa-miR-330-5p WNT5A 2.25110496739954 0.000275527655397415 -0.335254267155151 0.714960765245992 miRanda -0.317182601686914 0.00013146381356929 NA NA NA hsa-miR-582-5p WNT5A 0.685177900016753 0.447761540297692 -0.335254267155151 0.714960765245992 miRNATAP -0.175734719122522 0.00222477334080145 NA NA NA hsa-miR-616-5p WNT5A 2.48416313933027 0.00318247475868827 -0.335254267155151 0.714960765245992 mirMAP -0.276707442691596 0.000306684343847227 NA NA NA hsa-miR-92a-3p WNT5A 1.87892405805529 1.27013821556583e-05 -0.335254267155151 0.714960765245992 miRNAWalker2_validate -0.492024474546178 3.85220646721685e-05 NA NA NA