miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-5p ABL1 0.604314269683977 0.00140009936153214 -1.32037015957096 1.87647767985755e-18 miRNAWalker2_validate -0.231253752376574 6.2902850853714e-09 NA NA NA hsa-miR-128-3p ABL1 1.63756041666078 6.79626586407187e-14 -1.32037015957096 1.87647767985755e-18 MirTarget -0.210223041949341 2.63836453167807e-10 NA NA NA hsa-miR-136-5p ABL1 2.09637138292451 1.50140005592201e-10 -1.32037015957096 1.87647767985755e-18 mirMAP -0.120417712577766 7.75492266171278e-08 NA NA NA hsa-miR-140-3p ABL1 0.0608890720479334 0.727716871248724 -1.32037015957096 1.87647767985755e-18 MirTarget;PITA -0.14166082047536 0.00130100831768621 NA NA NA hsa-miR-141-3p ABL1 5.02396127982626 2.19224509139725e-24 -1.32037015957096 1.87647767985755e-18 MirTarget -0.175107254317894 1.9871253927784e-40 NA NA NA hsa-miR-149-5p ABL1 2.94200492826326 4.93436498919036e-14 -1.32037015957096 1.87647767985755e-18 miRNAWalker2_validate -0.143502376394447 3.49799913508757e-15 NA NA NA hsa-miR-15b-3p ABL1 2.33847028227712 4.29662877950836e-19 -1.32037015957096 1.87647767985755e-18 MirTarget -0.226389114724505 2.98490463631649e-17 NA NA NA hsa-miR-15b-5p ABL1 1.57112623124278 9.14247846750597e-13 -1.32037015957096 1.87647767985755e-18 mirMAP -0.249296693193715 3.02725198543686e-14 NA NA NA hsa-miR-16-5p ABL1 1.75824877145857 1.68592440033108e-16 -1.32037015957096 1.87647767985755e-18 mirMAP -0.310820336280616 3.75259721680265e-21 NA NA NA hsa-miR-19a-3p ABL1 3.42309334186656 3.02671914353412e-28 -1.32037015957096 1.87647767985755e-18 mirMAP -0.162387067627272 2.91974538664916e-13 NA NA NA hsa-miR-200a-3p ABL1 4.59434485520731 6.38952518573476e-18 -1.32037015957096 1.87647767985755e-18 MirTarget -0.148306180031242 1.0002237901953e-31 NA NA NA hsa-miR-26a-2-3p ABL1 0.823520019989974 0.00017092160823769 -1.32037015957096 1.87647767985755e-18 mirMAP -0.152618088179323 1.05762015103927e-05 NA NA NA hsa-miR-29a-5p ABL1 1.46749674755271 3.34605004270294e-07 -1.32037015957096 1.87647767985755e-18 MirTarget -0.114712372263782 2.92669427439134e-05 NA NA NA hsa-miR-29b-3p ABL1 1.65828197923813 1.02676780888141e-09 -1.32037015957096 1.87647767985755e-18 miRNATAP -0.226156505548727 1.19896226753111e-17 NA NA NA hsa-miR-29c-3p ABL1 -0.00968972577705429 0.97099586346872 -1.32037015957096 1.87647767985755e-18 miRNATAP -0.177447451684939 2.67475171467947e-10 NA NA NA hsa-miR-30b-3p ABL1 0.834142820354026 0.000972582820878813 -1.32037015957096 1.87647767985755e-18 mirMAP -0.152363471011564 3.25049904656188e-07 NA NA NA hsa-miR-30b-5p ABL1 0.800822374912712 0.000133601914525413 -1.32037015957096 1.87647767985755e-18 MirTarget;miRNATAP -0.212394163898943 2.63303999024585e-09 NA NA NA hsa-miR-30c-5p ABL1 0.778774633108 0.000285599212429136 -1.32037015957096 1.87647767985755e-18 MirTarget;miRNATAP -0.242607960634266 2.27192473406919e-12 NA NA NA hsa-miR-30d-5p ABL1 0.675423997639582 0.00270618816039773 -1.32037015957096 1.87647767985755e-18 MirTarget;miRNATAP -0.212422034659354 1.49043808471987e-10 NA NA NA hsa-miR-30e-5p ABL1 1.23904909539663 1.35561917122157e-09 -1.32037015957096 1.87647767985755e-18 MirTarget;miRNATAP -0.3467622622202 2.38742749053345e-23 NA NA NA hsa-miR-3127-5p ABL1 1.51846438737133 3.59571251672767e-07 -1.32037015957096 1.87647767985755e-18 MirTarget -0.136540309175573 3.72097100552687e-08 NA NA NA hsa-miR-330-5p ABL1 1.15100069700871 4.85551805046014e-07 -1.32037015957096 1.87647767985755e-18 MirTarget -0.224068027721259 3.32355451679908e-12 NA NA NA hsa-miR-361-5p ABL1 0.971859117235239 5.30236555707088e-09 -1.32037015957096 1.87647767985755e-18 miRanda -0.317700517390337 7.86933437215808e-13 NA NA NA hsa-miR-423-5p ABL1 0.963563145758616 9.86109015204915e-07 -1.32037015957096 1.87647767985755e-18 MirTarget -0.329711312044519 3.9739184786006e-19 NA NA NA hsa-miR-484 ABL1 1.81844463411787 1.82951571230938e-15 -1.32037015957096 1.87647767985755e-18 miRNAWalker2_validate -0.280122803941197 1.14978159043687e-19 NA NA NA hsa-miR-503-5p ABL1 3.66513190181895 6.60300917645278e-21 -1.32037015957096 1.87647767985755e-18 mirMAP -0.148758426639936 3.84030071766847e-15 NA NA NA hsa-miR-181a-5p ATM 2.29556023480783 1.8138457900616e-21 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.126923788457429 2.84207726303723e-05 24531888;27150990;21102523;26113450;23656790 Ataxia-telangiectasia mutation ATM was predicted as a target gene of miR-181a with bioinformatics analysis and was verified by lucifersae reporter assay; A luciferase reporter assay demonstrated that ATM was a direct target of miR-181a miR-181a mimics transfection down regulated ATM mRNA and protein expression; There was inverse correlation between miR-181a and ATM protein expression in gastric cancer and normal gastric tissues; Our study demonstrates that over-expression of miR-181a might be involved in development of gastric cancer by promoting proliferation and inhibiting apoptosis probably through directly targeting ATM miR-181a modulation may be a potential strategy for the development of miRNA-based therapy of gastric cancer;MiR 181a Promotes Proliferation of Human Acute Myeloid Leukemia Cells by Targeting ATM; Dual luciferase reporter gene assay showed that miR-181a significantly suppressed the reporter gene activity containing ATM 3'-UTR by about 56.8% P < 0.05 but it didn't suppress the reporter gene activity containing 3'-UTR ATM mutation; Western blot showed that miR-181a significantly downregulated the expression of ATM in human leukemia cells; It is also found that miR-181a was significantly increased in AML which showed a negative correlation with ATM expression; miR-181a promotes cell proliferation in AML by regulating the tumor suppressor ATM thus it plays the role as oncogene in pathogenesis of AML;Ataxia telangiectasia mutated ATM a target gene of miR-181 exhibited reduced expression in mammospheres and upon TGF-β treatment;miR 181a promotes G1/S transition and cell proliferation in pediatric acute myeloid leukemia by targeting ATM; Pediatric AML patients and healthy controls were enrolled and the expression of miR-181a and ataxia telangiectasia mutated ATM in tissues were examined using quantitative PCR; Moreover cell proliferation and cell cycle were evaluated in several cell lines HL60 NB4 and K562 by using flow cytometry after transfected with miR-181a mimics and inhibitors or ATM siRNA and control siRNA; Finally ATM as the potential target protein of miR-181a was examined; We found that miR-181a was significantly increased in pediatric AML which showed an inverse association with ATM expression; Luciferase activity of the reporter construct identified ATM as the direct molecular target of miR-181a; The results revealed novel mechanism through which miR-181a regulates G1/S transition and cell proliferation in pediatric AML by regulating the tumor suppressor ATM providing insights into the molecular mechanism in pediatric AML;We report that miR-181a and miR-181b were overexpressed in more aggressive breast cancers and their expression correlates inversely with ATM levels ;;;; gastric cancer;acute myeloid leukemia;breast cancer;acute myeloid leukemia;breast cancer hsa-miR-181b-5p ATM 2.49307679431293 3.92829250217627e-20 -0.694304374354523 1.11905560067279e-05 MirTarget -0.106546210489637 8.13310251996423e-05 21102523;23656790 Ataxia telangiectasia mutated ATM a target gene of miR-181 exhibited reduced expression in mammospheres and upon TGF-β treatment;We report that miR-181a and miR-181b were overexpressed in more aggressive breast cancers and their expression correlates inversely with ATM levels ; breast cancer;breast cancer hsa-miR-186-5p ATM 1.47445398888668 3.0781726595413e-15 -0.694304374354523 1.11905560067279e-05 mirMAP -0.162572896698222 4.94897138455636e-05 NA NA NA hsa-miR-18a-5p ATM 3.78535678765353 3.72446596213886e-26 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.132647027735553 2.53006799595493e-10 23437304;25963391;23857602;23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression colorectal cancer;cervical and endocervical cancer;breast cancer;colon cancer hsa-miR-19b-3p ATM 2.49529833021187 1.57028265846699e-23 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate -0.169669050219426 4.03808006538527e-09 NA NA NA hsa-miR-21-5p ATM 2.73773305747971 1.38864982139576e-43 -0.694304374354523 1.11905560067279e-05 mirMAP -0.176310423151013 4.47713388674926e-07 26289851 MiR-21 is an oncomiR that is overexpressed in nearly all cancers including ATC; Hence suppression of miR-21 could pave the way for ATC therapy thyroid cancer hsa-miR-26a-2-3p ATM 0.823520019989974 0.00017092160823769 -0.694304374354523 1.11905560067279e-05 MirTarget -0.118965349103283 0.000759103078575479 NA NA NA hsa-miR-26b-5p ATM 0.885393662798425 3.2116297961629e-06 -0.694304374354523 1.11905560067279e-05 MirTarget -0.112936121726645 0.00532953311791061 NA NA NA hsa-miR-30c-5p ATM 0.778774633108 0.000285599212429136 -0.694304374354523 1.11905560067279e-05 mirMAP -0.107066600206639 0.00288450607513559 NA NA NA hsa-miR-324-5p ATM 2.95683728155095 1.32960514360912e-20 -0.694304374354523 1.11905560067279e-05 miRanda -0.111813212915851 1.04521240946738e-06 NA NA NA hsa-miR-362-3p ATM 2.0756816987665 3.89026064579331e-12 -0.694304374354523 1.11905560067279e-05 miRanda -0.112278812357676 1.35632724301173e-05 NA NA NA hsa-miR-455-5p ATM 2.2582442061694 1.43472128037398e-13 -0.694304374354523 1.11905560067279e-05 miRanda -0.106749319544671 1.15313735793322e-05 NA NA NA hsa-miR-576-5p ATM 2.20467023993664 3.4053475193793e-19 -0.694304374354523 1.11905560067279e-05 mirMAP -0.17622953753732 2.51071157737834e-09 NA NA NA hsa-miR-590-3p ATM 2.59289455139753 1.03200520972022e-21 -0.694304374354523 1.11905560067279e-05 miRanda;mirMAP -0.147925962529486 7.50176131513898e-08 NA NA NA hsa-miR-590-5p ATM 3.18300989862077 2.06813568597893e-26 -0.694304374354523 1.11905560067279e-05 mirMAP -0.155698076358082 1.697182104602e-10 NA NA NA hsa-miR-92a-3p ATM 2.06460102658973 1.44784291084757e-19 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate -0.174566583478402 5.02119051710453e-08 NA NA NA hsa-miR-139-5p BUB1 -1.52606598644743 1.20474151350665e-08 2.99497420874398 2.90503661450991e-26 miRanda -0.245529252241127 3.91470133994434e-06 NA NA NA hsa-miR-30c-5p CCNA1 0.778774633108 0.000285599212429136 -0.799524339575412 0.295283787863684 MirTarget -0.758549977409093 9.50998783716041e-06 NA NA NA hsa-miR-30d-5p CCNA1 0.675423997639582 0.00270618816039773 -0.799524339575412 0.295283787863684 MirTarget -1.00433531983321 5.2492230769758e-10 NA NA NA hsa-miR-30e-5p CCNA1 1.23904909539663 1.35561917122157e-09 -0.799524339575412 0.295283787863684 MirTarget -0.832005732765763 2.71456932387536e-06 NA NA NA hsa-miR-335-5p CCNA1 1.77247705492746 2.22457658872091e-06 -0.799524339575412 0.295283787863684 miRNAWalker2_validate -0.252904547371949 0.0095171880094844 NA NA NA hsa-miR-218-5p CCNA2 -0.573801507392184 0.0551983860126703 2.81251184571189 1.99970506215583e-25 MirTarget -0.145050755643329 0.00176557013722416 NA NA NA hsa-miR-29c-3p CCNA2 -0.00968972577705429 0.97099586346872 2.81251184571189 1.99970506215583e-25 MirTarget -0.340911968917063 2.88619895890886e-11 NA NA NA hsa-miR-139-5p CCNB1 -1.52606598644743 1.20474151350665e-08 2.5876663861041 1.47856299409004e-23 miRanda -0.228760920591688 2.21107834979824e-06 NA NA NA hsa-miR-23b-3p CCNB2 -0.251132426825047 0.150200321210792 3.44127671644327 6.15726356293966e-31 miRNAWalker2_validate -0.35472868706084 7.95902161675979e-05 NA NA NA hsa-miR-106a-5p CCND1 2.48882002962836 1.99757727374521e-12 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.278915751904438 2.46069960202024e-07 NA NA NA hsa-miR-15b-5p CCND1 1.57112623124278 9.14247846750597e-13 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.2743592470705 0.00190316455907807 NA NA NA hsa-miR-186-5p CCND1 1.47445398888668 3.0781726595413e-15 0.0828319966762319 0.840332435689448 mirMAP -0.319993507741074 0.0020448551843367 NA NA NA hsa-miR-193a-3p CCND1 1.60460546928078 2.86169793322984e-07 0.0828319966762319 0.840332435689448 MirTarget;PITA;miRanda -0.351734964348069 1.30056584701733e-08 NA NA NA hsa-miR-195-5p CCND1 -1.44753678070504 8.70594292149271e-09 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.232938095379387 0.00278406868271715 21350001;26631043;25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma ;;metastasis;poor survival breast cancer;cervical and endocervical cancer;sarcoma hsa-miR-20b-5p CCND1 2.07706563022469 1.10107236083433e-05 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.250774310314038 8.20956147612201e-10 NA NA NA hsa-miR-340-5p CCND1 0.30282999308409 0.157744789519131 0.0828319966762319 0.840332435689448 mirMAP -0.529085780655826 9.29072904979919e-09 NA NA NA hsa-miR-374b-5p CCND1 0.0654362503857184 0.722673188879465 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;MirTarget -0.416222074203323 0.000132219455740898 NA NA NA hsa-miR-497-5p CCND1 0.0257087130056286 0.918145413833358 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.30773442281542 0.000110601843767413 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-7-1-3p CCND1 1.84950311431067 1.25300363397654e-13 0.0828319966762319 0.840332435689448 mirMAP -0.247700635127977 0.00138754391814163 NA NA NA hsa-miR-769-3p CCND1 2.19896922202687 5.69250370895053e-12 0.0828319966762319 0.840332435689448 mirMAP -0.231146561837838 0.000210475786569237 NA NA NA hsa-let-7a-3p CCND2 1.42015538786275 7.03375209382654e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.440555668621489 2.14967330798537e-06 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7a-5p CCND2 0.618599506841644 2.76973453058748e-05 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.503238938401113 9.92586197811674e-05 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7b-3p CCND2 0.868207752019623 1.30460056774366e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.292600423696445 0.00203496813099611 NA NA NA hsa-let-7b-5p CCND2 0.604314269683977 0.00140009936153214 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.372644945722985 0.000202758514128247 NA NA NA hsa-let-7e-5p CCND2 0.860104282510173 6.04758298373779e-05 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.254279031336757 0.00390630067355032 NA NA NA hsa-let-7f-1-3p CCND2 1.55054488387679 7.31326775537952e-11 -2.42747067684236 2.06814828958882e-10 mirMAP -0.349075249109793 1.19776506071246e-05 NA NA NA hsa-let-7f-5p CCND2 0.495648727272215 0.00355972741198794 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.395067035409999 0.000431247614557398 NA NA NA hsa-let-7g-5p CCND2 1.20061455355116 1.50237505511483e-12 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.78482657734201 2.2934101130382e-13 NA NA NA hsa-miR-106a-5p CCND2 2.48882002962836 1.99757727374521e-12 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.460265785003224 1.90572227650597e-20 NA NA NA hsa-miR-106b-5p CCND2 2.46782146831112 1.36171495805632e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.723802321113981 4.62852843641777e-26 NA NA NA hsa-miR-10b-3p CCND2 0.77597971642517 0.00264877454133753 -2.42747067684236 2.06814828958882e-10 mirMAP -0.299055149155965 4.03151748542262e-05 NA NA NA hsa-miR-130b-5p CCND2 2.9963110846538 1.98883029416455e-18 -2.42747067684236 2.06814828958882e-10 mirMAP -0.524276006004661 2.15252650149472e-24 NA NA NA hsa-miR-141-3p CCND2 5.02396127982626 2.19224509139725e-24 -2.42747067684236 2.06814828958882e-10 MirTarget;TargetScan -0.336824974322951 8.46453268716016e-23 NA NA NA hsa-miR-151a-3p CCND2 1.24018761527407 1.08839919675408e-07 -2.42747067684236 2.06814828958882e-10 mirMAP -0.618872158164273 1.57062556462901e-15 NA NA NA hsa-miR-15a-5p CCND2 2.34669284378787 1.69544424500258e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.558385276567589 5.78612617845985e-14 NA NA NA hsa-miR-15b-5p CCND2 1.57112623124278 9.14247846750597e-13 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.814047353716774 1.36644748676197e-24 NA NA NA hsa-miR-16-2-3p CCND2 2.31623086727196 4.29838149388188e-20 -2.42747067684236 2.06814828958882e-10 mirMAP -0.524415153934827 5.42085565840902e-14 NA NA NA hsa-miR-16-5p CCND2 1.75824877145857 1.68592440033108e-16 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRNATAP -0.624880555696101 7.5948593080299e-14 NA NA NA hsa-miR-17-5p CCND2 3.2710598467455 9.93128340539455e-27 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.576586035201243 5.39762569803648e-26 NA NA NA hsa-miR-181a-2-3p CCND2 2.19062681262366 3.81790102612782e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.371385706331271 5.48097191184985e-10 NA NA NA hsa-miR-182-5p CCND2 3.53923166221814 5.07781258121574e-21 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.418107303561313 5.83833309647385e-20 NA NA NA hsa-miR-183-5p CCND2 4.19757025992371 4.79612296318304e-26 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.406097602561121 1.1832385157764e-21 NA NA NA hsa-miR-185-5p CCND2 2.34016206907488 1.17481626642022e-26 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.596214855521239 5.09732672184216e-14 NA NA NA hsa-miR-186-5p CCND2 1.47445398888668 3.0781726595413e-15 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.753228825405404 3.55444659312987e-15 NA NA NA hsa-miR-188-5p CCND2 2.52825126596644 6.78099435999778e-14 -2.42747067684236 2.06814828958882e-10 PITA;mirMAP -0.327199573697285 9.78244941189197e-09 NA NA NA hsa-miR-191-5p CCND2 2.30038190670664 9.93191704545938e-17 -2.42747067684236 2.06814828958882e-10 MirTarget -0.63056469865633 4.58280529094783e-24 NA NA NA hsa-miR-19a-3p CCND2 3.42309334186656 3.02671914353412e-28 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.478555105133488 2.03415225430867e-18 NA NA NA hsa-miR-19b-3p CCND2 2.49529833021187 1.57028265846699e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.644240893236217 5.93065810659583e-21 NA NA NA hsa-miR-200a-3p CCND2 4.59434485520731 6.38952518573476e-18 -2.42747067684236 2.06814828958882e-10 MirTarget -0.322639326506763 1.12744821991113e-23 NA NA NA hsa-miR-20a-5p CCND2 3.15577933619191 4.19753346442454e-25 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.552675029838617 1.98133209896024e-23 NA NA NA hsa-miR-20b-5p CCND2 2.07706563022469 1.10107236083433e-05 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.296015277168294 1.16933542500196e-14 NA NA NA hsa-miR-21-3p CCND2 2.19296355304364 4.63665722759779e-15 -2.42747067684236 2.06814828958882e-10 mirMAP -0.266420777851125 4.25531839718567e-05 NA NA NA hsa-miR-224-3p CCND2 1.87536386559317 6.15140969394846e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.234939524450716 1.27567539540633e-08 NA NA NA hsa-miR-26b-5p CCND2 0.885393662798425 3.2116297961629e-06 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.333191234288059 0.000785967313666436 NA NA NA hsa-miR-29b-3p CCND2 1.65828197923813 1.02676780888141e-09 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.181452610770389 0.00800883535071036 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-301a-3p CCND2 2.81024345929638 2.29784847962242e-17 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.490714440601798 1.13987935585442e-18 NA NA NA hsa-miR-3065-3p CCND2 2.16221780121195 9.65525739884541e-09 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.234083951058536 1.60505150894369e-06 NA NA NA hsa-miR-3065-5p CCND2 2.74629919868982 1.86846589298284e-08 -2.42747067684236 2.06814828958882e-10 mirMAP -0.236930159170796 2.73973057309239e-07 NA NA NA hsa-miR-30d-3p CCND2 0.977747550180601 4.3048212205381e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.514799428246913 2.69094766335815e-11 NA NA NA hsa-miR-30e-3p CCND2 -0.215663037684509 0.235375122783546 -2.42747067684236 2.06814828958882e-10 mirMAP -0.317748716556734 0.00256884077064715 NA NA NA hsa-miR-32-3p CCND2 2.02436999565685 5.94091197945307e-09 -2.42747067684236 2.06814828958882e-10 mirMAP -0.37065809204682 5.74913234109809e-10 NA NA NA hsa-miR-320a CCND2 0.438165828017084 0.0390159073347133 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;mirMAP;miRNATAP -0.366959333753783 3.90012764364419e-05 NA NA NA hsa-miR-320b CCND2 1.55692969039548 1.41071034251915e-08 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.389495451202309 5.62361965191887e-09 NA NA NA hsa-miR-324-3p CCND2 2.08739139768981 3.11885987067952e-13 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.569926030100518 1.57078270718816e-20 NA NA NA hsa-miR-331-5p CCND2 2.17414714166315 1.54547681391888e-18 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.55418360999634 4.24751797285043e-14 NA NA NA hsa-miR-335-5p CCND2 1.77247705492746 2.22457658872091e-06 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.196309653133352 7.59470226154717e-05 NA NA NA hsa-miR-33a-3p CCND2 1.72765312072219 1.51784443453521e-07 -2.42747067684236 2.06814828958882e-10 MirTarget -0.474892003832155 3.60158523540778e-15 NA NA NA hsa-miR-3607-3p CCND2 2.68532138541128 5.66716351955047e-14 -2.42747067684236 2.06814828958882e-10 mirMAP -0.253991708738003 1.1264040881505e-06 NA NA NA hsa-miR-374b-3p CCND2 0.930487774873495 2.74420094310516e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.379294826109076 7.61411367904561e-06 NA NA NA hsa-miR-378a-3p CCND2 -0.10995720000828 0.716188270032681 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.264766627168263 2.14263562743039e-05 NA NA NA hsa-miR-423-5p CCND2 0.963563145758616 9.86109015204915e-07 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.681308347713645 2.78087673863117e-13 NA NA NA hsa-miR-424-5p CCND2 1.61930224569578 1.89642549274994e-10 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.208747216207423 0.00424259734488207 NA NA NA hsa-miR-429 CCND2 4.48815175680773 2.44117492218206e-17 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.316889169500172 1.77696184266368e-22 NA NA NA hsa-miR-450b-5p CCND2 1.69244418548325 1.68064054148881e-10 -2.42747067684236 2.06814828958882e-10 MirTarget;PITA;miRNATAP -0.299286922863212 1.69011727706147e-05 NA NA NA hsa-miR-500a-5p CCND2 1.72110365584658 3.0807246212659e-10 -2.42747067684236 2.06814828958882e-10 mirMAP -0.230284164405623 0.000679591942778451 NA NA NA hsa-miR-501-5p CCND2 1.93654809410041 1.3779381780759e-10 -2.42747067684236 2.06814828958882e-10 PITA;mirMAP;miRNATAP -0.278516160908165 9.05358509837179e-06 NA NA NA hsa-miR-503-5p CCND2 3.66513190181895 6.60300917645278e-21 -2.42747067684236 2.06814828958882e-10 MirTarget -0.31264390956225 5.2815091282227e-11 25860935 We then identified two targets of miR-503 CCND2 and CCND3 breast cancer hsa-miR-550a-5p CCND2 2.11025227932763 6.94489556637146e-12 -2.42747067684236 2.06814828958882e-10 MirTarget -0.44540662591501 2.41152035101861e-14 NA NA NA hsa-miR-589-3p CCND2 2.51971841868825 2.39125940264107e-11 -2.42747067684236 2.06814828958882e-10 mirMAP -0.360588568041429 3.76015378643146e-11 NA NA NA hsa-miR-590-3p CCND2 2.59289455139753 1.03200520972022e-21 -2.42747067684236 2.06814828958882e-10 miRanda;mirMAP -0.419988530136573 3.79848108645639e-10 NA NA NA hsa-miR-590-5p CCND2 3.18300989862077 2.06813568597893e-26 -2.42747067684236 2.06814828958882e-10 mirMAP -0.50562344923364 6.73026539304424e-18 NA NA NA hsa-miR-660-5p CCND2 1.82692095272076 1.92040083607196e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.361636929774302 8.5078492819456e-07 NA NA NA hsa-miR-7-1-3p CCND2 1.84950311431067 1.25300363397654e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.518854235917429 5.32697612805784e-13 NA NA NA hsa-miR-708-3p CCND2 2.80907765282502 3.07460722669281e-14 -2.42747067684236 2.06814828958882e-10 mirMAP -0.177604972093223 0.000316375213374722 NA NA NA hsa-miR-708-5p CCND2 3.38051631555486 5.12590198690777e-18 -2.42747067684236 2.06814828958882e-10 mirMAP -0.19367896307831 2.62089031491477e-05 NA NA NA hsa-miR-877-5p CCND2 2.94916202082736 1.8151927276044e-13 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.361363420346396 6.83899428438154e-13 NA NA NA hsa-miR-93-5p CCND2 3.03961860136032 1.11672209617395e-24 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.640135233296746 3.73391346199191e-30 NA NA NA hsa-miR-944 CCND2 2.91186649218281 1.31574753528144e-06 -2.42747067684236 2.06814828958882e-10 PITA;mirMAP -0.168575408637895 9.32931241492905e-08 NA NA NA hsa-miR-96-5p CCND2 4.89433085814374 1.92000659886961e-31 -2.42747067684236 2.06814828958882e-10 TargetScan;miRNATAP -0.382951897231727 7.25785958201884e-21 NA NA NA hsa-miR-27b-3p CCND3 0.196007704287769 0.295630157035388 0.142518749044219 0.397307080616203 miRNAWalker2_validate -0.133645004740845 0.00231237621077374 NA NA NA hsa-miR-28-3p CCNE2 -0.411384408160536 0.0101470262574251 2.48639159684199 1.03709868150437e-14 PITA;miRNATAP -0.310525624419087 0.00235062649082895 NA NA NA hsa-miR-142-3p CDC14A 2.75247908790621 1.45636065474764e-12 -0.495332113336858 0.0192739818208126 miRanda -0.11115150685965 1.25130539903518e-05 NA NA NA hsa-miR-146b-5p CDC14A 1.75587235896724 1.15724631266659e-07 -0.495332113336858 0.0192739818208126 miRanda -0.199677564469368 2.20378603566429e-11 NA NA NA hsa-miR-199a-3p CDC14A 0.640600337515787 0.0380326905134914 -0.495332113336858 0.0192739818208126 PITA -0.137900590234212 2.95128552688487e-05 NA NA NA hsa-miR-199b-3p CDC14A 0.643923492750702 0.0371742251925406 -0.495332113336858 0.0192739818208126 PITA -0.137758866288808 2.96883452834062e-05 NA NA NA hsa-miR-338-3p CDC14A 0.453166438193782 0.144583389707558 -0.495332113336858 0.0192739818208126 miRanda -0.128970897884948 8.84999365244738e-05 NA NA NA hsa-miR-146b-3p CDC14B 1.10569195233795 0.000660632782194023 -0.813031036253329 2.26301828056095e-05 miRNATAP -0.132900483868 2.98561053281691e-06 NA NA NA hsa-miR-185-5p CDC14B 2.34016206907488 1.17481626642022e-26 -0.813031036253329 2.26301828056095e-05 MirTarget -0.120565204914778 0.00277919238518517 NA NA NA hsa-miR-193a-5p CDC14B 0.562511612963676 0.0239254699649222 -0.813031036253329 2.26301828056095e-05 miRNATAP -0.139676439108688 0.00019925947287135 NA NA NA hsa-miR-27a-3p CDC14B 1.66542180327138 4.93775737894805e-13 -0.813031036253329 2.26301828056095e-05 miRNATAP -0.157848652342753 6.40267865517349e-05 NA NA NA hsa-miR-590-3p CDC14B 2.59289455139753 1.03200520972022e-21 -0.813031036253329 2.26301828056095e-05 miRanda;mirMAP -0.115542286151583 0.000615627863489471 NA NA NA hsa-miR-590-5p CDC14B 3.18300989862077 2.06813568597893e-26 -0.813031036253329 2.26301828056095e-05 miRanda -0.107042210327028 0.000376131610502395 NA NA NA hsa-miR-23b-3p CDC20 -0.251132426825047 0.150200321210792 3.88984891303216 1.21088023421357e-31 miRNAWalker2_validate -0.444513507865143 9.49371726362108e-06 NA NA NA hsa-let-7c-5p CDC25A -2.07847142524506 5.51224567263294e-09 2.48536917904182 2.96461081172939e-22 MirTarget -0.105960871849238 0.00321755436661061 25909324 MicroRNA let 7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma; The aim of the present study was to determine whether the cell cycle regulator CDC25A is involved in the antitumor effect of let-7c in HCC; The luciferase reporter assay showed that CDC25A was a direct target of let-7c and that let-7c inhibited the expression of CDC25A protein by directly targeting its 3' UTR; In conclusion this study indicates that let-7c suppresses HCC progression possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules progression liver cancer hsa-miR-141-3p CDC25B 5.02396127982626 2.19224509139725e-24 0.783166040527924 0.00478680511553999 TargetScan -0.118085231335799 3.69707768792997e-06 NA NA NA hsa-miR-429 CDC25B 4.48815175680773 2.44117492218206e-17 0.783166040527924 0.00478680511553999 miRanda -0.194288018952407 1.45177267683282e-16 NA NA NA hsa-miR-199b-5p CDC7 0.218704279044827 0.519493319158441 1.84291213753287 5.30624853814022e-16 MirTarget;miRanda -0.105030153461088 0.00177926113580324 NA NA NA hsa-miR-101-3p CDK6 0.522819989585461 0.00375627731618038 -0.774202349805119 0.064787030605636 mirMAP -0.728162460077577 6.25283110395347e-11 NA NA NA hsa-miR-103a-3p CDK6 1.44083190496858 1.53799939616416e-13 -0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRNATAP -0.738308002788887 9.81610683337994e-14 NA NA NA hsa-miR-106a-5p CDK6 2.48882002962836 1.99757727374521e-12 -0.774202349805119 0.064787030605636 mirMAP -0.23817017599031 1.76828696872453e-05 NA NA NA hsa-miR-106b-5p CDK6 2.46782146831112 1.36171495805632e-23 -0.774202349805119 0.064787030605636 mirMAP -0.506703206296417 3.6460930000884e-11 NA NA NA hsa-miR-107 CDK6 1.30977326593435 1.30372468603965e-11 -0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase;PITA;miRNATAP -0.535825292120497 1.58523365512466e-07 19407485;22491216;21264532;19688090 Enforced expression of miR-107 in MiaPACA-2 and PANC-1 cells downregulated in vitro growth and this was associated with repression of the putative miR-107 target cyclin-dependent kinase 6 thereby providing a functional basis for the epigenetic inactivation of this miRNA in pancreatic cancer;Levels of known miR-107 targets protein kinase Cε PKCε cyclin-dependent kinase 6 CDK6 and hypoxia-inducible factor 1-β HIF1-β decreased following NP/pre-miR-107 treatment;We have identified miR-107 as a potential regulator of CDK6 expression; A bioinformatics search revealed a putative target site for miR-107 within the CDK6 3' untranslated region; Expression of miR-107 in gastric cancer cell lines was found inversely correlated with CDK6 expression; miR-107 could significantly suppress CDK6 3' UTR luciferase reporter activity and this effect was not detectable when the putative 3' UTR target site was mutated; Consistent with the results of the reporter assay ectopic expression of miR-107 reduced both mRNA and protein expression levels of CDK6 inhibited proliferation induced G1 cell cycle arrest and blocked invasion of the gastric cancer cells; Our results suggest that miR-107 may have a tumor suppressor function by directly targeting CDK6 to inhibit the proliferation and invasion activities of gastric cancer cells;Using miRNA-target prediction analyses and the array data we listed up a set of likely targets of miR-107 and miR-185 for G1 cell cycle arrest and validate a subset of them using real-time RT-PCR and immunoblotting for CDK6 ;;; pancreatic cancer;head and neck cancer;gastric cancer;lung squamous cell cancer hsa-miR-141-3p CDK6 5.02396127982626 2.19224509139725e-24 -0.774202349805119 0.064787030605636 TargetScan;miRNATAP -0.280860480145549 9.29496321423746e-14 NA NA NA hsa-miR-148b-3p CDK6 1.97815018171325 6.07715327281595e-26 -0.774202349805119 0.064787030605636 mirMAP -0.689303354555952 6.39464837566244e-12 NA NA NA hsa-miR-148b-5p CDK6 2.18024067300781 2.84770452413262e-14 -0.774202349805119 0.064787030605636 mirMAP -0.337506526013873 2.86415828815712e-06 NA NA NA hsa-miR-15a-5p CDK6 2.34669284378787 1.69544424500258e-23 -0.774202349805119 0.064787030605636 miRNATAP -0.331153083238962 5.09100262040034e-05 NA NA NA hsa-miR-16-1-3p CDK6 2.56983217111073 3.02262181237943e-20 -0.774202349805119 0.064787030605636 mirMAP -0.214448709710321 0.00270430071750274 NA NA NA hsa-miR-17-5p CDK6 3.2710598467455 9.93128340539455e-27 -0.774202349805119 0.064787030605636 TargetScan;mirMAP -0.168193833076577 0.00702167500067962 NA NA NA hsa-miR-182-5p CDK6 3.53923166221814 5.07781258121574e-21 -0.774202349805119 0.064787030605636 mirMAP -0.342809938093979 8.28135113019132e-12 NA NA NA hsa-miR-185-5p CDK6 2.34016206907488 1.17481626642022e-26 -0.774202349805119 0.064787030605636 miRNAWalker2_validate -0.418001590004214 1.44577313582161e-06 19688090 Using miRNA-target prediction analyses and the array data we listed up a set of likely targets of miR-107 and miR-185 for G1 cell cycle arrest and validate a subset of them using real-time RT-PCR and immunoblotting for CDK6 lung squamous cell cancer hsa-miR-191-5p CDK6 2.30038190670664 9.93191704545938e-17 -0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase -0.711524835034044 1.00464473356187e-26 NA NA NA hsa-miR-200a-3p CDK6 4.59434485520731 6.38952518573476e-18 -0.774202349805119 0.064787030605636 miRNATAP -0.336691687165474 2.80396820395637e-22 24009066 microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6 liver cancer hsa-miR-200b-3p CDK6 3.78235093249346 3.18343003239465e-14 -0.774202349805119 0.064787030605636 mirMAP -0.361406013032565 5.1342063993974e-22 NA NA NA hsa-miR-200c-3p CDK6 3.50132673580082 2.42716349086937e-15 -0.774202349805119 0.064787030605636 mirMAP -0.320385878451071 9.82419842455136e-14 NA NA NA hsa-miR-20a-5p CDK6 3.15577933619191 4.19753346442454e-25 -0.774202349805119 0.064787030605636 mirMAP -0.188851341814342 0.00261077138275469 NA NA NA hsa-miR-20b-5p CDK6 2.07706563022469 1.10107236083433e-05 -0.774202349805119 0.064787030605636 mirMAP -0.293918462449454 1.28039252847365e-12 26166554 The transfection of miR-20b into EJ cells induced G1 phase cell cycle arrest via the decreased expression of cyclin D1 CDK2 and CDK6 without affecting another G1 phase cell cycle regulator cyclin E bladder cancer hsa-miR-29b-3p CDK6 1.65828197923813 1.02676780888141e-09 -0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase;miRNATAP -0.224461155748557 0.0022317971289129 23245396;25472644;26180082;23591808;27230400;20086245 The IFN-γ-induced G1-arrest of melanoma cells involves down-regulation of CDK6 which we proved to be a direct target of miR-29 in these cells;Moreover miR-29b inhibited the expression of MCL1 and CDK6;Knockdown of NTSR1 increased the expression of miR-29b-1 and miR-129-3p which were responsible for the decreased CDK6 expression;Here we have identified the oncogene cyclin-dependent protein kinase 6 CDK6 as a direct target of miR-29b in lung cancer;MiR 29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6; In this study we investigated the role of miR-29b as a novel regulator of CDK6 using bioinformatics methods; We demonstrated that CDK6 can be downregulated by miR-29b via binding to the 3'-UTR region in osteosarcoma cells; Furthermore we identified an inverse correlation between miR-29b and CDK6 protein levels in osteosarcoma tissues; The results revealed that miR-29b acts as a tumor suppressor of osteosarcoma by targeting CDK6 in the proliferation and migration processes;microRNA expression profile and identification of miR 29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma; Furthermore we demonstrate miR-29 inhibition of CDK6 protein and mRNA levels by direct binding to 3'-untranslated region; Inverse correlation between miR-29 and CDK6 was observed in MCL ;;;;; melanoma;colorectal cancer;glioblastoma;lung cancer;sarcoma;lymphoma hsa-miR-29c-3p CDK6 -0.00968972577705429 0.97099586346872 -0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase;miRNATAP -0.580639861705711 5.15109801814716e-15 26396669 Furthermore through qPCR and Western blot assays confirmed that overexpression of miR-29c reduced CDK6 mRNA and protein levels; miR-29c could inhibit the proliferation migration and invasion of bladder cancer cells via regulating CDK6 bladder cancer hsa-miR-30b-5p CDK6 0.800822374912712 0.000133601914525413 -0.774202349805119 0.064787030605636 mirMAP -0.540189292799148 1.61932566833175e-08 NA NA NA hsa-miR-30c-5p CDK6 0.778774633108 0.000285599212429136 -0.774202349805119 0.064787030605636 mirMAP -0.727075100437403 2.31302505595533e-15 NA NA NA hsa-miR-30d-3p CDK6 0.977747550180601 4.3048212205381e-05 -0.774202349805119 0.064787030605636 mirMAP -0.561334088800932 1.30656981501796e-11 NA NA NA hsa-miR-30d-5p CDK6 0.675423997639582 0.00270618816039773 -0.774202349805119 0.064787030605636 mirMAP -0.785477623920694 1.19356262091604e-19 NA NA NA hsa-miR-30e-3p CDK6 -0.215663037684509 0.235375122783546 -0.774202349805119 0.064787030605636 mirMAP -0.686700064203411 6.84849442105303e-10 NA NA NA hsa-miR-30e-5p CDK6 1.23904909539663 1.35561917122157e-09 -0.774202349805119 0.064787030605636 mirMAP -0.817058326987529 5.2385475320723e-18 NA NA NA hsa-miR-32-3p CDK6 2.02436999565685 5.94091197945307e-09 -0.774202349805119 0.064787030605636 mirMAP -0.249929478125797 0.000125097299153361 NA NA NA hsa-miR-32-5p CDK6 2.34056473219422 6.24134585974322e-20 -0.774202349805119 0.064787030605636 miRNATAP -0.295032649435311 9.55907730341779e-05 NA NA NA hsa-miR-320a CDK6 0.438165828017084 0.0390159073347133 -0.774202349805119 0.064787030605636 PITA;miRNATAP -0.376224025256019 8.78451776886182e-05 NA NA NA hsa-miR-330-3p CDK6 0.876747334239085 0.00073709016089703 -0.774202349805119 0.064787030605636 PITA;mirMAP -0.427895514362065 2.76679372346252e-08 NA NA NA hsa-miR-335-3p CDK6 3.08791651139852 5.31309869723517e-12 -0.774202349805119 0.064787030605636 mirMAP -0.153251191165497 0.000493500059209 NA NA NA hsa-miR-335-5p CDK6 1.77247705492746 2.22457658872091e-06 -0.774202349805119 0.064787030605636 mirMAP -0.166621089394833 0.00183832978506415 NA NA NA hsa-miR-33a-5p CDK6 3.79671563098419 1.15966309820345e-18 -0.774202349805119 0.064787030605636 miRNATAP -0.187324589024782 0.000129271884100387 NA NA NA hsa-miR-34a-3p CDK6 1.75590866103657 8.02801510630657e-09 -0.774202349805119 0.064787030605636 mirMAP -0.376950684687892 1.73963312821001e-07 21702042;26104764 Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004 ; bladder cancer;lung cancer hsa-miR-34a-5p CDK6 1.9016323452565 1.43092834643601e-14 -0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase;miRNATAP -0.519263514540718 3.07288169543583e-11 21702042;26104764 Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004 ; bladder cancer;lung cancer hsa-miR-3613-5p CDK6 2.64358387329263 1.0373753017245e-24 -0.774202349805119 0.064787030605636 miRNATAP -0.21181572504448 0.005712534663484 NA NA NA hsa-miR-362-5p CDK6 1.59303749908759 9.582675908797e-08 -0.774202349805119 0.064787030605636 mirMAP -0.313855526332272 2.37748256302272e-06 NA NA NA hsa-miR-378a-3p CDK6 -0.10995720000828 0.716188270032681 -0.774202349805119 0.064787030605636 mirMAP -0.397192555694478 2.01427891085214e-09 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-425-5p CDK6 3.07071373939774 4.02947460586085e-25 -0.774202349805119 0.064787030605636 mirMAP -0.484163394229156 1.07269848409271e-14 NA NA NA hsa-miR-429 CDK6 4.48815175680773 2.44117492218206e-17 -0.774202349805119 0.064787030605636 mirMAP;miRNATAP -0.337479964584767 4.50509176972113e-22 NA NA NA hsa-miR-450b-5p CDK6 1.69244418548325 1.68064054148881e-10 -0.774202349805119 0.064787030605636 mirMAP -0.201384976718992 0.00743415077141657 NA NA NA hsa-miR-497-5p CDK6 0.0257087130056286 0.918145413833358 -0.774202349805119 0.064787030605636 miRNATAP -0.245332138327252 0.00264647539053154 NA NA NA hsa-miR-500a-5p CDK6 1.72110365584658 3.0807246212659e-10 -0.774202349805119 0.064787030605636 mirMAP -0.232725295393576 0.00140479513304275 NA NA NA hsa-miR-501-3p CDK6 1.83132758513743 1.10971547702065e-10 -0.774202349805119 0.064787030605636 PITA;TargetScan;miRNATAP -0.414303056979818 1.84547250783893e-09 NA NA NA hsa-miR-502-3p CDK6 1.50560877085049 1.2647489756373e-11 -0.774202349805119 0.064787030605636 PITA;miRNATAP -0.4275399463222 1.5008131463888e-06 NA NA NA hsa-miR-590-5p CDK6 3.18300989862077 2.06813568597893e-26 -0.774202349805119 0.064787030605636 mirMAP;miRNATAP -0.201344503599928 0.00209551899019727 NA NA NA hsa-miR-592 CDK6 1.51765968871077 0.000636335248013204 -0.774202349805119 0.064787030605636 mirMAP -0.143284258807414 0.0019385912538056 NA NA NA hsa-miR-660-5p CDK6 1.82692095272076 1.92040083607196e-13 -0.774202349805119 0.064787030605636 mirMAP -0.339962414215247 1.75914031108584e-05 NA NA NA hsa-miR-664a-3p CDK6 0.634721925861133 0.00520070178640421 -0.774202349805119 0.064787030605636 mirMAP -0.700489354678287 6.77094321174664e-16 NA NA NA hsa-miR-671-5p CDK6 2.97733652243246 1.21148452344738e-23 -0.774202349805119 0.064787030605636 PITA;miRNATAP -0.255214929025129 0.000181908946141654 NA NA NA hsa-miR-92a-3p CDK6 2.06460102658973 1.44784291084757e-19 -0.774202349805119 0.064787030605636 miRNATAP -0.240406113182612 0.00492937850760914 NA NA NA hsa-miR-93-5p CDK6 3.03961860136032 1.11672209617395e-24 -0.774202349805119 0.064787030605636 mirMAP -0.467996685199197 1.00999249823312e-13 NA NA NA hsa-let-7d-5p CDKN1A 1.33236798905207 1.1741085658466e-13 -1.29236263370998 3.21238784768704e-06 MirTarget -0.324235774348598 1.11339571601414e-05 NA NA NA hsa-let-7f-5p CDKN1A 0.495648727272215 0.00355972741198794 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;MirTarget -0.24004761105408 0.00296779895445168 NA NA NA hsa-let-7g-5p CDKN1A 1.20061455355116 1.50237505511483e-12 -1.29236263370998 3.21238784768704e-06 MirTarget -0.261596530769954 0.000909666186900533 NA NA NA hsa-miR-101-3p CDKN1A 0.522819989585461 0.00375627731618038 -1.29236263370998 3.21238784768704e-06 MirTarget -0.196450098291035 0.00981579805828264 NA NA NA hsa-miR-106a-5p CDKN1A 2.48882002962836 1.99757727374521e-12 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.128693729012364 0.000550088861161385 25510666 After prediction with online software we further used dual-luciferase reporter gene assay to ensure that TP53INP1 and CDKN1A might be the direct targets of miR-106a liver cancer hsa-miR-106b-5p CDKN1A 2.46782146831112 1.36171495805632e-23 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.301959313712314 4.48472102839421e-09 NA NA NA hsa-miR-17-5p CDKN1A 3.2710598467455 9.93128340539455e-27 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.172861511846616 3.07251784468708e-05 26482648;24989082 The low expressions of miR-17 and miR-92 families can maintain cisplatin resistance through the regulation of CDKN1A and RAD21;According to PicTar and Miranda algorithms which predicted CDKN1A p21 as a putative target of miR-17 a luciferase assay was performed and revealed that miR-17 directly targets the 3'-UTR of p21 mRNA drug resistance; lung squamous cell cancer;sarcoma hsa-miR-182-5p CDKN1A 3.53923166221814 5.07781258121574e-21 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate -0.109364926293111 0.00141758512280426 NA NA NA hsa-miR-20a-5p CDKN1A 3.15577933619191 4.19753346442454e-25 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.165884225022855 7.19614215488726e-05 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex colon cancer hsa-miR-20b-5p CDKN1A 2.07706563022469 1.10107236083433e-05 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.112000786094038 7.41332851839187e-05 NA NA NA hsa-miR-28-5p CDKN1A 0.230152919654905 0.0742909586754846 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.556544696034112 2.23374029772338e-07 NA NA NA hsa-miR-30b-3p CDKN1A 0.834142820354026 0.000972582820878813 -1.29236263370998 3.21238784768704e-06 MirTarget -0.188277179739766 0.000464764881340986 NA NA NA hsa-miR-335-5p CDKN1A 1.77247705492746 2.22457658872091e-06 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate -0.15287461273454 1.73689594092226e-05 NA NA NA hsa-miR-345-5p CDKN1A 3.63532310411307 2.2698112107996e-21 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget -0.214757145120261 7.64097376843956e-11 NA NA NA hsa-miR-363-3p CDKN1A 1.50575300026701 0.00020976164678918 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase -0.119979037678532 0.000289602460917026 NA NA NA hsa-miR-423-3p CDKN1A 2.57855385753676 9.19765570228097e-24 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase -0.200481634838583 5.95960562762572e-05 NA NA NA hsa-miR-423-5p CDKN1A 0.963563145758616 9.86109015204915e-07 -1.29236263370998 3.21238784768704e-06 MirTarget -0.179252711950689 0.00923809529808823 NA NA NA hsa-miR-491-5p CDKN1A 0.615770352820862 0.0418295628761654 -1.29236263370998 3.21238784768704e-06 miRanda -0.127626893732512 0.00809072721464231 NA NA NA hsa-miR-503-5p CDKN1A 3.66513190181895 6.60300917645278e-21 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase -0.108479527294966 0.00188268400827089 NA NA NA hsa-miR-505-5p CDKN1A 1.89243395287645 9.82003586561819e-12 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;MirTarget -0.197864415222474 3.15355511624094e-05 NA NA NA hsa-miR-93-5p CDKN1A 3.03961860136032 1.11672209617395e-24 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.230725362813635 6.59990926283075e-08 25633810 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC liver cancer hsa-miR-942-5p CDKN1A 2.35195531153712 5.45059325728841e-16 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate -0.260648356679274 4.62199208083779e-09 NA NA NA hsa-miR-96-5p CDKN1A 4.89433085814374 1.92000659886961e-31 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase -0.131322885353092 1.73810674264337e-05 26582573 Upregulation of microRNA 96 and its oncogenic functions by targeting CDKN1A in bladder cancer; Bioinformatics prediction combined with luciferase reporter assay were used to verify whether the cyclin-dependent kinase inhibitor CDKN1A was a potential target gene of miR-96; According to the data of miRTarBase CDKN1A might be a candidate target gene of miR-96; In addition luciferase reporter and Western blot assays respectively demonstrated that miR-96 could bind to the putative seed region in CDKN1A mRNA 3'UTR and significantly reduce the expression level of CDKN1A protein; Moreover we found that the inhibition of miR-96 expression remarkably decreased cell proliferation and promoted cell apoptosis of BC cell lines which was consistent with the findings observed following the introduction of CDKN1A cDNA without 3'UTR restored miR-96; Upregulation of miR-96 may contribute to aggressive malignancy partly through suppressing CDKN1A protein expression in BC cells bladder cancer hsa-miR-98-5p CDKN1A 1.11154309866014 1.24143909012085e-08 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;MirTarget -0.251133283878821 0.000264648620156197 NA NA NA hsa-miR-221-3p CDKN1B 0.451556679024397 0.0909808299917811 0.111589542072177 0.453851218822883 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.108173416521144 5.5134677794152e-05 23637992;19953484;23939688;19126397;20146005;23967190;17569667;22992757;17721077;20461750 miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression progression;;;;staging;tumorigenesis;;;;;poor survival breast cancer;glioblastoma;breast cancer;melanoma;liver cancer;pancreatic cancer;prostate cancer;breast cancer;glioblastoma;ovarian cancer hsa-miR-24-3p CDKN1B 0.99989036772428 1.35595013650376e-07 0.111589542072177 0.453851218822883 miRNAWalker2_validate;miRNATAP -0.155773035071718 3.27990988982606e-05 26847530;26044523 The biological significance of miR-24 expression in prostate cancer cells was assessed by a series of in vitro bioassays and the effect on proposed targets p27 CDKN1B and p16 CDK2NA was investigated;With the bioinformatic method we further identified that p27Kip1 is a direct target of miR-24-3p and its protein level was negatively regulated by miR-24-3p ; prostate cancer;breast cancer hsa-miR-221-3p CDKN1C 0.451556679024397 0.0909808299917811 -1.44787932669971 3.93876960323515e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.248677574564568 0.000109625580592135 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-222-3p CDKN1C 0.851783756239071 0.00266783568486918 -1.44787932669971 3.93876960323515e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.245957660234723 4.42600884082533e-05 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-32-5p CDKN1C 2.34056473219422 6.24134585974322e-20 -1.44787932669971 3.93876960323515e-05 MirTarget;miRNATAP -0.170383081011306 0.00808508551108614 NA NA NA hsa-miR-34a-5p CDKN1C 1.9016323452565 1.43092834643601e-14 -1.44787932669971 3.93876960323515e-05 miRNATAP -0.28214470568661 2.69554466730922e-05 NA NA NA hsa-miR-590-3p CDKN1C 2.59289455139753 1.03200520972022e-21 -1.44787932669971 3.93876960323515e-05 miRanda -0.295748909086173 1.56568596656934e-06 NA NA NA hsa-miR-125a-5p CDKN2B 0.599529391575274 0.0102300147180307 -0.112970149969128 0.832353274540521 miRanda -0.310089305986085 0.00518147219807009 NA NA NA hsa-miR-28-5p CDKN2B 0.230152919654905 0.0742909586754846 -0.112970149969128 0.832353274540521 miRanda -0.668331542152576 0.00118921247732729 NA NA NA hsa-miR-330-3p CDKN2B 0.876747334239085 0.00073709016089703 -0.112970149969128 0.832353274540521 mirMAP;miRNATAP -0.269857955336921 0.0065388859673795 NA NA NA hsa-miR-582-5p CDKN2B 0.609226359812689 0.032988717891497 -0.112970149969128 0.832353274540521 miRNATAP -0.437780407212853 1.01848865191063e-06 NA NA NA hsa-miR-671-5p CDKN2B 2.97733652243246 1.21148452344738e-23 -0.112970149969128 0.832353274540521 PITA -0.427729850509145 6.77528914607289e-07 NA NA NA hsa-miR-944 CDKN2B 2.91186649218281 1.31574753528144e-06 -0.112970149969128 0.832353274540521 mirMAP;miRNATAP -0.216243202750685 5.52569916158531e-07 NA NA NA hsa-miR-182-5p CDKN2C 3.53923166221814 5.07781258121574e-21 0.22688212352847 0.433133415352322 MirTarget -0.132415467904401 0.00017052034340074 NA NA NA hsa-miR-34a-5p CDKN2C 1.9016323452565 1.43092834643601e-14 0.22688212352847 0.433133415352322 miRNAWalker2_validate -0.218709270480303 6.47001667111707e-05 NA NA NA hsa-miR-139-5p CHEK1 -1.52606598644743 1.20474151350665e-08 1.60009495890486 3.70484455888763e-14 miRanda -0.117325843833051 0.0025015103290901 NA NA NA hsa-miR-186-5p CREBBP 1.47445398888668 3.0781726595413e-15 -0.451040948976341 0.000687386434761364 mirMAP;miRNATAP -0.14581204925591 1.28616268232458e-05 NA NA NA hsa-miR-26b-5p CREBBP 0.885393662798425 3.2116297961629e-06 -0.451040948976341 0.000687386434761364 miRNATAP -0.128164022830949 0.000145104031692185 NA NA NA hsa-miR-30a-5p DBF4 -0.878357906436456 0.000509952992366057 1.38395284691374 1.23439093811915e-16 MirTarget -0.111246726548135 0.00077150457041199 NA NA NA hsa-miR-23b-3p E2F1 -0.251132426825047 0.150200321210792 2.30029093432361 6.42780154222742e-15 miRNAWalker2_validate -0.372989133559732 1.24396495100595e-05 NA NA NA hsa-let-7e-5p E2F2 0.860104282510173 6.04758298373779e-05 2.70854220767479 1.83941887423315e-16 MirTarget -0.2247104962792 0.00356440988375461 NA NA NA hsa-miR-125a-5p E2F2 0.599529391575274 0.0102300147180307 2.70854220767479 1.83941887423315e-16 MirTarget -0.301148309325287 2.03394231315254e-05 NA NA NA hsa-miR-125b-5p E2F3 -1.16462950151259 0.000288900271798384 0.864092775291151 0.000386058881687169 miRNAWalker2_validate;miRTarBase;miRNATAP -0.142837036867265 9.12438435050649e-05 20549700;22523546 E2F3 which was critical for G1/S transition and was overexpressed in most of poor-differentiated bladder cancers was identified as a target of miR-125b by luciferase assay; Introduction of miR-125b could reduce the expression of E2F3 protein but not the E2F3 mRNA;Moreover we demonstrated that the E2F3 was a direct target of miR-125b in breast cancer cells ; bladder cancer;breast cancer hsa-miR-145-5p E2F3 -1.55259331973517 9.97889123247165e-07 0.864092775291151 0.000386058881687169 miRNATAP -0.17491700228664 1.71848339541538e-06 25762621 miR 145 mediates the antiproliferative and gene regulatory effects of vitamin D3 by directly targeting E2F3 in gastric cancer cells; Furthermore miR-145 expression was lower in tumors compared with matched normal samples and correlated with increased the E2F3 transcription factor protein staining gastric cancer hsa-miR-199a-5p E2F3 0.592984035153911 0.0674836634175293 0.864092775291151 0.000386058881687169 PITA;miRanda -0.109850587440245 0.00261789381880117 NA NA NA hsa-miR-199b-5p E2F3 0.218704279044827 0.519493319158441 0.864092775291151 0.000386058881687169 PITA;miRanda -0.111598702165076 0.00137866302517256 NA NA NA hsa-miR-140-5p EP300 0.844753502512594 3.73722278438606e-05 -0.259813561364416 0.130645976324069 miRNAWalker2_validate -0.116180580124631 0.0041461159891489 NA NA NA hsa-miR-142-5p EP300 1.17581605694506 0.0018174701991234 -0.259813561364416 0.130645976324069 PITA;mirMAP;miRNATAP -0.111374437902145 2.72973348003874e-07 23342264 In contrast to the mouse p300 gene the human p300 gene was not found to be a target for miR-142-5p B cell lymphoma hsa-miR-193b-3p EP300 2.25711804611899 4.1940744806631e-14 -0.259813561364416 0.130645976324069 miRNAWalker2_validate -0.105745678811168 8.10977033783005e-05 NA NA NA hsa-miR-22-3p EP300 1.21545661147757 1.61670170137775e-13 -0.259813561364416 0.130645976324069 MirTarget;miRNATAP -0.202351996320887 4.21898434047145e-05 NA NA NA hsa-miR-29b-1-5p EP300 1.55384379072167 4.76870585070176e-05 -0.259813561364416 0.130645976324069 MirTarget -0.128437592094259 1.17066262616741e-08 NA NA NA hsa-miR-342-3p EP300 1.49115144672245 1.43879249744621e-07 -0.259813561364416 0.130645976324069 MirTarget;PITA;miRanda;miRNATAP -0.216290263558714 1.26951899192842e-14 NA NA NA hsa-miR-361-3p EP300 1.07367425434318 1.73142774168958e-09 -0.259813561364416 0.130645976324069 PITA -0.267683295831071 4.11859386761575e-09 NA NA NA hsa-let-7c-5p ESPL1 -2.07847142524506 5.51224567263294e-09 2.85443632204445 3.18991347452993e-21 MirTarget -0.128252897735711 0.00241026096803068 NA NA NA hsa-miR-130b-3p GADD45A 3.5350292994509 1.73934183852569e-27 -0.835839078652441 0.000140836693353512 MirTarget;miRNATAP -0.17218937101763 1.35434055056965e-08 NA NA NA hsa-miR-148b-3p GADD45A 1.97815018171325 6.07715327281595e-26 -0.835839078652441 0.000140836693353512 MirTarget -0.24164313540326 6.68989940877406e-06 NA NA NA hsa-miR-301a-3p GADD45A 2.81024345929638 2.29784847962242e-17 -0.835839078652441 0.000140836693353512 MirTarget;miRNATAP -0.112998413130989 0.000548458732723422 NA NA NA hsa-miR-324-5p GADD45A 2.95683728155095 1.32960514360912e-20 -0.835839078652441 0.000140836693353512 miRanda -0.112457495567732 0.000439233642516274 NA NA NA hsa-miR-421 GADD45A 1.17791565395543 6.78526676976629e-06 -0.835839078652441 0.000140836693353512 miRanda -0.133567846694638 0.00100215803079645 NA NA NA hsa-miR-454-3p GADD45A 2.47234127820054 1.12878018736016e-21 -0.835839078652441 0.000140836693353512 MirTarget;miRNATAP -0.123232081874385 0.00233561552908576 NA NA NA hsa-miR-590-3p GADD45A 2.59289455139753 1.03200520972022e-21 -0.835839078652441 0.000140836693353512 miRanda;mirMAP -0.116878603221423 0.00246827969058347 NA NA NA hsa-miR-1976 GADD45B 2.06550563678192 7.81396978619772e-18 -2.10522351126521 1.24009438337654e-11 miRNATAP -0.438571553390836 3.56919131064351e-13 NA NA NA hsa-miR-324-3p GADD45B 2.08739139768981 3.11885987067952e-13 -2.10522351126521 1.24009438337654e-11 MirTarget;miRNATAP -0.529388083839586 5.82182378729412e-27 NA NA NA hsa-miR-590-3p GADD45B 2.59289455139753 1.03200520972022e-21 -2.10522351126521 1.24009438337654e-11 miRanda -0.441564740260131 2.37587329223105e-16 NA NA NA hsa-miR-1976 GADD45G 2.06550563678192 7.81396978619772e-18 -1.14052103223901 0.000287911213048388 MirTarget -0.223301232794066 0.000270386119057603 NA NA NA hsa-miR-320a GADD45G 0.438165828017084 0.0390159073347133 -1.14052103223901 0.000287911213048388 miRanda -0.202148212458203 0.00541824995825031 NA NA NA hsa-miR-320b GADD45G 1.55692969039548 1.41071034251915e-08 -1.14052103223901 0.000287911213048388 miRanda -0.18771629419395 0.000624415279589848 NA NA NA hsa-miR-429 GADD45G 4.48815175680773 2.44117492218206e-17 -1.14052103223901 0.000287911213048388 miRNATAP -0.111263953867699 5.40997990169216e-05 NA NA NA hsa-miR-139-5p GSK3B -1.52606598644743 1.20474151350665e-08 0.406268283461383 0.000508906658360755 mirMAP -0.100160771461377 1.20519675407331e-06 NA NA NA hsa-miR-145-5p HDAC2 -1.55259331973517 9.97889123247165e-07 0.313249438836848 0.0173965895741346 miRNAWalker2_validate -0.114388862244791 4.4414066471407e-09 23499894 MiR 145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer; Ectopic expression of miRNA mimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells; In conclusion we suggest that loss or suppression of miR-145 may cause aberrant overexpression of HDAC2 and promote HCC tumorigenesis tumorigenesis liver cancer hsa-miR-139-5p MAD2L1 -1.52606598644743 1.20474151350665e-08 2.00724624656882 4.89851921308556e-15 miRanda -0.164206894868644 0.000493729129472996 NA NA NA hsa-miR-139-5p MCM2 -1.52606598644743 1.20474151350665e-08 1.99506656346364 1.17970168824543e-16 miRanda -0.158431519913373 0.000362981859305698 NA NA NA hsa-miR-23b-3p MCM4 -0.251132426825047 0.150200321210792 1.39849326394513 2.34346690188324e-09 MirTarget -0.181675521298078 0.00684858149402919 NA NA NA hsa-miR-320a MCM6 0.438165828017084 0.0390159073347133 0.938445532915834 8.36738953271919e-07 miRanda -0.147972276621915 0.000803182496823708 NA NA NA hsa-let-7f-5p MYC 0.495648727272215 0.00355972741198794 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.302610362502413 0.00593577090066522 NA NA NA hsa-let-7g-5p MYC 1.20061455355116 1.50237505511483e-12 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.647634835001101 8.67569135821405e-10 NA NA NA hsa-miR-320a MYC 0.438165828017084 0.0390159073347133 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.270203083250914 0.00203008366284758 25736597 Furthermore progesterone P4 promoted the expression of miR-320a by repressing c-Myc expression while estrogen E2 exerted the opposite effect breast cancer hsa-miR-320b MYC 1.55692969039548 1.41071034251915e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.211227042104883 0.00142753396089349 26487644 miR 320b suppresses cell proliferation by targeting c Myc in human colorectal cancer cells; Overexpression of miR-320b in CRC cells was statistically correlated with a decrease of cell growth in vitro and in vivo while c-MYC was identified as a target gene of miR-320b in CRC; Furthermore it was found that up-regulation of c-Myc can attenuate the effects induced by miR-320b; Our identification of c-MYC as a target gene of miR-320b provides new insights into the pathophysiology of CRC proliferation and identifies miR-320b as a novel therapeutic target for the treatment of CRC colorectal cancer hsa-miR-335-5p MYC 1.77247705492746 2.22457658872091e-06 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.15527675337735 0.00141118517916367 NA NA NA hsa-miR-34a-5p MYC 1.9016323452565 1.43092834643601e-14 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.359767953473847 5.62932761832786e-07 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-423-5p MYC 0.963563145758616 9.86109015204915e-07 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.592117097378242 1.10389937335588e-10 NA NA NA hsa-miR-429 MYC 4.48815175680773 2.44117492218206e-17 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.269400502460394 6.09134482841112e-17 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-744-5p MYC 1.48254348878737 3.23019501613577e-09 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.254793177391621 0.000439915184612437 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-miR-98-5p MYC 1.11154309866014 1.24143909012085e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.602921793997467 5.7325871539819e-11 NA NA NA hsa-miR-320a PRKDC 0.438165828017084 0.0390159073347133 0.387105708224396 0.0474683117539971 miRanda -0.138856783288065 0.00192627611059365 NA NA NA hsa-miR-139-5p RAD21 -1.52606598644743 1.20474151350665e-08 0.32492798724512 0.0457716054104185 miRanda -0.113489955395024 8.14296865639197e-05 NA NA NA hsa-miR-106a-5p RB1 2.48882002962836 1.99757727374521e-12 -0.453832349621869 0.0641807656041741 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.207146169416987 9.29749287107945e-11 NA NA NA hsa-miR-106b-5p RB1 2.46782146831112 1.36171495805632e-23 -0.453832349621869 0.0641807656041741 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.179483553741754 7.94488434930651e-05 NA NA NA hsa-miR-1301-3p RB1 2.54959518791507 5.26618591274892e-18 -0.453832349621869 0.0641807656041741 MirTarget -0.110515731150229 0.00424502776795956 NA NA NA hsa-miR-17-5p RB1 3.2710598467455 9.93128340539455e-27 -0.453832349621869 0.0641807656041741 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.176683696046635 9.85172436957833e-07 NA NA NA hsa-miR-186-5p RB1 1.47445398888668 3.0781726595413e-15 -0.453832349621869 0.0641807656041741 mirMAP -0.2131057133901 0.000571651734362544 NA NA NA hsa-miR-192-5p RB1 2.69002528723195 1.22990188194432e-16 -0.453832349621869 0.0641807656041741 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.153739765157225 1.07660617507336e-05 NA NA NA hsa-miR-20a-5p RB1 3.15577933619191 4.19753346442454e-25 -0.453832349621869 0.0641807656041741 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.177203787298137 1.08156578899176e-06 NA NA NA hsa-miR-20b-5p RB1 2.07706563022469 1.10107236083433e-05 -0.453832349621869 0.0641807656041741 MirTarget;miRNATAP -0.162939349977104 1.91769055660246e-11 NA NA NA hsa-miR-342-3p RB1 1.49115144672245 1.43879249744621e-07 -0.453832349621869 0.0641807656041741 miRanda -0.13204082155202 0.00138214080790059 NA NA NA hsa-miR-361-5p RB1 0.971859117235239 5.30236555707088e-09 -0.453832349621869 0.0641807656041741 miRanda -0.22842795046456 0.00129446298255419 NA NA NA hsa-miR-590-5p RB1 3.18300989862077 2.06813568597893e-26 -0.453832349621869 0.0641807656041741 miRanda -0.111817623842902 0.00347383644547651 NA NA NA hsa-miR-93-5p RB1 3.03961860136032 1.11672209617395e-24 -0.453832349621869 0.0641807656041741 miRNAWalker2_validate;MirTarget;miRNATAP -0.167206817770783 8.36156887116369e-06 NA NA NA hsa-miR-199b-5p RBL1 0.218704279044827 0.519493319158441 1.07061654035036 4.84800665443549e-05 miRanda -0.114364377483128 0.00253555908216694 NA NA NA hsa-miR-140-5p RBL2 0.844753502512594 3.73722278438606e-05 -0.598910927791217 0.000318998334086003 miRanda -0.11867323020571 0.00262978059184829 NA NA NA hsa-miR-142-5p RBL2 1.17581605694506 0.0018174701991234 -0.598910927791217 0.000318998334086003 PITA -0.103739178866545 9.11193439074471e-07 NA NA NA hsa-miR-576-5p RBL2 2.20467023993664 3.4053475193793e-19 -0.598910927791217 0.000318998334086003 MirTarget;PITA -0.126790145697504 5.30686012438181e-05 NA NA NA hsa-miR-30a-5p SKP2 -0.878357906436456 0.000509952992366057 1.39036825082714 1.26915627098892e-08 MirTarget;miRNATAP -0.140580766184416 0.00308149309508355 NA NA NA hsa-miR-181a-5p SMAD2 2.29556023480783 1.8138457900616e-21 -0.217872679367038 0.049686680004959 mirMAP -0.112519930018506 7.12492899365623e-08 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 2.49307679431293 3.92829250217627e-20 -0.217872679367038 0.049686680004959 mirMAP -0.102985568847665 2.98550912982442e-08 NA NA NA hsa-miR-26a-5p SMAD2 0.0464832722967259 0.752628386912329 -0.217872679367038 0.049686680004959 mirMAP -0.11130754251612 0.0026935683249941 NA NA NA hsa-miR-361-3p SMAD2 1.07367425434318 1.73142774168958e-09 -0.217872679367038 0.049686680004959 miRNATAP -0.114638945395339 0.000110242156000821 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-let-7a-2-3p SMAD3 0.0400317820791161 0.91528727576685 -0.145068391221315 0.569239559252949 mirMAP -0.127624470471724 0.000115244641159406 NA NA NA hsa-miR-125b-2-3p SMAD3 -1.83175829351767 2.94917958974528e-05 -0.145068391221315 0.569239559252949 mirMAP -0.167358601156691 2.00437048846808e-09 NA NA NA hsa-miR-127-5p SMAD3 1.19850695520181 4.10976607177645e-05 -0.145068391221315 0.569239559252949 mirMAP -0.175774439508378 2.40422906256706e-05 NA NA NA hsa-miR-132-3p SMAD3 0.156276992635384 0.408190812100704 -0.145068391221315 0.569239559252949 mirMAP -0.307625427852275 2.61092084929535e-06 NA NA NA hsa-miR-142-5p SMAD3 1.17581605694506 0.0018174701991234 -0.145068391221315 0.569239559252949 PITA -0.121783193917905 0.000168543842540946 NA NA NA hsa-miR-145-5p SMAD3 -1.55259331973517 9.97889123247165e-07 -0.145068391221315 0.569239559252949 MirTarget;miRNATAP -0.102333497957109 0.0076425159078547 27237033 MiR 145 and miR 203 represses TGF β induced epithelial mesenchymal transition and invasion by inhibiting SMAD3 in non small cell lung cancer cells; siRNA-mediated knockdown of SMAD3 copied the phenotype of miR-145 and miR-203 overexpression in A549 and 95C cells; MiR-145 and miR-203 inhibited TGF-β-induced EMT and invasion through repression of SMAD3 in NSCLC cells lung squamous cell cancer hsa-miR-155-5p SMAD3 1.20164021433135 0.00086170622431261 -0.145068391221315 0.569239559252949 miRNAWalker2_validate -0.167586664196246 6.20173080978562e-07 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-188-5p SMAD3 2.52825126596644 6.78099435999778e-14 -0.145068391221315 0.569239559252949 PITA -0.184950370967834 7.35063541952032e-07 NA NA NA hsa-miR-18a-5p SMAD3 3.78535678765353 3.72446596213886e-26 -0.145068391221315 0.569239559252949 miRNAWalker2_validate -0.136878014915373 5.63544047470077e-05 23249750 The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling glioblastoma hsa-miR-195-5p SMAD3 -1.44753678070504 8.70594292149271e-09 -0.145068391221315 0.569239559252949 MirTarget -0.155082880098317 0.00129697117488075 27206216 MiR 195 Suppresses Cervical Cancer Migration and Invasion Through Targeting Smad3; The purposes of this study were to investigate the role of miR-195 in cervical cancer and clarify the regulation of Smad3 by miR-195; Smad3 was verified as a direct target of miR-195 which was further confirmed by the inverse expression of miR-195 and Smad3 in patients' specimens cervical and endocervical cancer hsa-miR-212-3p SMAD3 0.357878936470387 0.232446214501331 -0.145068391221315 0.569239559252949 mirMAP -0.196270501722139 1.760966299711e-06 NA NA NA hsa-miR-326 SMAD3 0.715313016136042 0.0610265683213359 -0.145068391221315 0.569239559252949 miRanda -0.127854658986735 7.18944162313972e-05 NA NA NA hsa-miR-424-5p SMAD3 1.61930224569578 1.89642549274994e-10 -0.145068391221315 0.569239559252949 MirTarget -0.137637867799144 0.0037931514509118 27655675 miR 424 5p promotes proliferation of gastric cancer by targeting Smad3 through TGF β signaling pathway; QRT-PCR was used to determine the expression levels of miR-424-5p and Smad3; Luciferase reporter assay and western blotting were used to prove that Smad3 was one of the direct targets of miR-424-5p; In addition luciferase reporter assay and western blotting assay revealed that Smad3 was a direct target of miR-424-5p; Over-expression of Smad3 could partially reverse the effects of miR-424-5p on GC cell proliferation; Our study further revealed that miR-424-5p could inhibit TGF-β signaling pathway by Smad3 gastric cancer hsa-miR-485-3p SMAD3 0.442820096243914 0.166634696770945 -0.145068391221315 0.569239559252949 MirTarget -0.146973333951251 0.000145374061338494 NA NA NA hsa-miR-495-3p SMAD3 -0.0847115949846082 0.763475496144456 -0.145068391221315 0.569239559252949 mirMAP -0.147079833458788 0.000814867470605654 NA NA NA hsa-miR-497-5p SMAD3 0.0257087130056286 0.918145413833358 -0.145068391221315 0.569239559252949 MirTarget -0.149416186909323 0.00253073754447704 NA NA NA hsa-miR-501-5p SMAD3 1.93654809410041 1.3779381780759e-10 -0.145068391221315 0.569239559252949 mirMAP -0.178593095060563 1.2547872342843e-05 NA NA NA hsa-miR-589-3p SMAD3 2.51971841868825 2.39125940264107e-11 -0.145068391221315 0.569239559252949 mirMAP -0.112359264624293 0.0019298395243008 NA NA NA hsa-let-7f-1-3p SMAD4 1.55054488387679 7.31326775537952e-11 -0.586921155134023 3.52416916552263e-06 mirMAP -0.106405479232356 4.39371133743738e-05 NA NA NA hsa-miR-140-5p SMAD4 0.844753502512594 3.73722278438606e-05 -0.586921155134023 3.52416916552263e-06 miRanda -0.114517150132142 0.000134319769998401 NA NA NA hsa-miR-146b-5p SMAD4 1.75587235896724 1.15724631266659e-07 -0.586921155134023 3.52416916552263e-06 PITA;miRanda;miRNATAP -0.103959435086478 8.75874581151263e-09 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-186-5p SMAD4 1.47445398888668 3.0781726595413e-15 -0.586921155134023 3.52416916552263e-06 miRNAWalker2_validate;mirMAP -0.107040467643529 0.000873099593755318 NA NA NA hsa-miR-2355-5p SMAD4 1.32510310704724 8.25139516692683e-07 -0.586921155134023 3.52416916552263e-06 MirTarget -0.100237269384076 8.83439826066143e-06 NA NA NA hsa-miR-26b-5p SMAD4 0.885393662798425 3.2116297961629e-06 -0.586921155134023 3.52416916552263e-06 MirTarget;miRNATAP -0.101564603889141 0.00171580634002753 24890815 Overexpression of miR-26b also repressed Smad4 expression whereas its inhibition elevated Smad4 expression; In HCC cell lines miR-26b targeted the 3'UTR of USP9X which in turn affects EMT through Smad4 and the TGF-β signaling pathway liver cancer hsa-miR-27a-3p SMAD4 1.66542180327138 4.93775737894805e-13 -0.586921155134023 3.52416916552263e-06 MirTarget -0.13536279837513 1.62491622147447e-07 NA NA NA hsa-miR-34a-5p SMAD4 1.9016323452565 1.43092834643601e-14 -0.586921155134023 3.52416916552263e-06 miRNATAP -0.121709073519824 3.8975183335493e-07 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-362-3p SMAD4 2.0756816987665 3.89026064579331e-12 -0.586921155134023 3.52416916552263e-06 miRNATAP -0.105074125190041 3.2218791406447e-07 NA NA NA hsa-miR-576-5p SMAD4 2.20467023993664 3.4053475193793e-19 -0.586921155134023 3.52416916552263e-06 mirMAP -0.106133513564488 8.78863207489382e-06 NA NA NA hsa-let-7g-5p SMC1A 1.20061455355116 1.50237505511483e-12 0.043831182387617 0.773298330936153 MirTarget -0.134829863013372 0.00155102065006135 NA NA NA hsa-miR-101-3p SMC1A 0.522819989585461 0.00375627731618038 0.043831182387617 0.773298330936153 mirMAP -0.236768801940013 4.64533901439356e-09 NA NA NA hsa-miR-181c-5p SMC1A 1.58587920618301 1.57506918816933e-10 0.043831182387617 0.773298330936153 mirMAP -0.111613137924956 0.000114342301365384 NA NA NA hsa-miR-218-5p SMC1A -0.573801507392184 0.0551983860126703 0.043831182387617 0.773298330936153 mirMAP -0.105234255044029 1.56648133305133e-05 NA NA NA hsa-miR-23b-3p SMC1A -0.251132426825047 0.150200321210792 0.043831182387617 0.773298330936153 mirMAP -0.133582876541337 0.00171021635432851 NA NA NA hsa-miR-320a SMC1A 0.438165828017084 0.0390159073347133 0.043831182387617 0.773298330936153 miRNAWalker2_validate -0.123748010459244 0.000360165063457412 NA NA NA hsa-miR-664a-3p SMC1A 0.634721925861133 0.00520070178640421 0.043831182387617 0.773298330936153 mirMAP -0.212742904131529 1.89458201251213e-11 NA NA NA hsa-miR-140-5p STAG1 0.844753502512594 3.73722278438606e-05 -0.245728256557948 0.202447685081763 miRanda -0.140589583336782 0.00196969431862876 NA NA NA hsa-miR-181a-5p STAG1 2.29556023480783 1.8138457900616e-21 -0.245728256557948 0.202447685081763 miRNATAP -0.192745786220098 1.20678724733294e-07 NA NA NA hsa-miR-181b-5p STAG1 2.49307679431293 3.92829250217627e-20 -0.245728256557948 0.202447685081763 miRNATAP -0.13252553009663 4.94978411132215e-05 NA NA NA hsa-miR-181c-5p STAG1 1.58587920618301 1.57506918816933e-10 -0.245728256557948 0.202447685081763 miRNATAP -0.167008337103045 5.08668923082694e-06 NA NA NA hsa-miR-186-5p STAG1 1.47445398888668 3.0781726595413e-15 -0.245728256557948 0.202447685081763 mirMAP -0.129074901029091 0.00801940221455764 NA NA NA hsa-miR-199a-5p STAG1 0.592984035153911 0.0674836634175293 -0.245728256557948 0.202447685081763 miRanda -0.100125528610105 0.000472484658614487 NA NA NA hsa-miR-199b-5p STAG1 0.218704279044827 0.519493319158441 -0.245728256557948 0.202447685081763 miRanda -0.133034156616684 1.00550560273833e-06 NA NA NA hsa-miR-26b-5p STAG1 0.885393662798425 3.2116297961629e-06 -0.245728256557948 0.202447685081763 miRNAWalker2_validate -0.171395587122058 0.000450364078328837 NA NA NA hsa-miR-30a-5p STAG1 -0.878357906436456 0.000509952992366057 -0.245728256557948 0.202447685081763 MirTarget -0.121027156231127 0.000983318474982777 NA NA NA hsa-miR-30b-5p STAG1 0.800822374912712 0.000133601914525413 -0.245728256557948 0.202447685081763 MirTarget -0.173916893740682 8.56438860947271e-05 NA NA NA hsa-miR-30c-5p STAG1 0.778774633108 0.000285599212429136 -0.245728256557948 0.202447685081763 MirTarget -0.260508785613256 1.05881604466486e-09 NA NA NA hsa-miR-30e-5p STAG1 1.23904909539663 1.35561917122157e-09 -0.245728256557948 0.202447685081763 MirTarget -0.181994541574127 4.88636592618739e-05 NA NA NA hsa-miR-320a STAG1 0.438165828017084 0.0390159073347133 -0.245728256557948 0.202447685081763 miRanda -0.131709119880455 0.00285372055906094 NA NA NA hsa-miR-495-3p STAG1 -0.0847115949846082 0.763475496144456 -0.245728256557948 0.202447685081763 mirMAP -0.106383912355682 0.00137299902541505 NA NA NA hsa-miR-22-3p STAG2 1.21545661147757 1.61670170137775e-13 -0.338909993805473 0.122578778455043 MirTarget;miRNATAP -0.200393237079955 0.0015819012208609 NA NA NA hsa-miR-29b-3p STAG2 1.65828197923813 1.02676780888141e-09 -0.338909993805473 0.122578778455043 MirTarget;miRNATAP -0.134116123976534 0.000461566033446376 NA NA NA hsa-miR-28-5p TFDP1 0.230152919654905 0.0742909586754846 0.846227916601966 2.69648378919315e-07 miRanda -0.177316566489884 0.00596177796758454 NA NA NA hsa-miR-30c-5p TFDP1 0.778774633108 0.000285599212429136 0.846227916601966 2.69648378919315e-07 MirTarget;miRNATAP -0.109466733444829 0.00357936011476302 NA NA NA hsa-miR-195-5p TFDP2 -1.44753678070504 8.70594292149271e-09 0.111740793683246 0.484512557595196 MirTarget;mirMAP -0.120790351409869 5.90082165938122e-05 NA NA NA hsa-miR-744-5p TGFB1 1.48254348878737 3.23019501613577e-09 -0.000200257511168367 0.999409206375481 miRNAWalker2_validate;miRNATAP -0.229419410482444 6.9384219754003e-06 NA NA NA hsa-miR-107 TGFB2 1.30977326593435 1.30372468603965e-11 -1.19931727990522 0.00330886829654418 miRanda -0.51939474457829 1.98547903259176e-07 NA NA NA hsa-miR-126-5p TGFB2 0.895338176458417 2.33372756450713e-05 -1.19931727990522 0.00330886829654418 mirMAP -0.25743093726133 0.00599073764101041 NA NA NA hsa-miR-130b-3p TGFB2 3.5350292994509 1.73934183852569e-27 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.344962470893237 7.65363506175553e-10 NA NA NA hsa-miR-141-3p TGFB2 5.02396127982626 2.19224509139725e-24 -1.19931727990522 0.00330886829654418 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.360699351018386 8.70106540908034e-24 NA NA NA hsa-miR-148a-3p TGFB2 1.26728238710376 2.52325607402829e-06 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.286009485859132 8.40361643900754e-05 NA NA NA hsa-miR-148b-3p TGFB2 1.97815018171325 6.07715327281595e-26 -1.19931727990522 0.00330886829654418 MirTarget -0.76533615341931 3.3613707731401e-15 NA NA NA hsa-miR-149-5p TGFB2 2.94200492826326 4.93436498919036e-14 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.268302009449797 3.19540597089803e-08 NA NA NA hsa-miR-186-5p TGFB2 1.47445398888668 3.0781726595413e-15 -1.19931727990522 0.00330886829654418 mirMAP -0.621355169758057 1.07645506474653e-09 NA NA NA hsa-miR-200a-3p TGFB2 4.59434485520731 6.38952518573476e-18 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.349625252947739 2.44117272738656e-25 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 3.12352008343999 9.49391438647189e-07 -1.19931727990522 0.00330886829654418 MirTarget -0.137892151335788 5.76268091391752e-06 NA NA NA hsa-miR-29b-3p TGFB2 1.65828197923813 1.02676780888141e-09 -1.19931727990522 0.00330886829654418 miRTarBase;MirTarget;miRNATAP -0.231729413265765 0.0012231669483933 NA NA NA hsa-miR-29c-3p TGFB2 -0.00968972577705429 0.97099586346872 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.531424404132598 2.96641887384219e-13 NA NA NA hsa-miR-301a-3p TGFB2 2.81024345929638 2.29784847962242e-17 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.322704555190408 7.77034372961379e-08 NA NA NA hsa-miR-32-3p TGFB2 2.02436999565685 5.94091197945307e-09 -1.19931727990522 0.00330886829654418 mirMAP -0.27315114570865 1.69846948907938e-05 NA NA NA hsa-miR-320a TGFB2 0.438165828017084 0.0390159073347133 -1.19931727990522 0.00330886829654418 miRanda -0.39585907442477 2.33018021074793e-05 NA NA NA hsa-miR-320b TGFB2 1.55692969039548 1.41071034251915e-08 -1.19931727990522 0.00330886829654418 miRanda -0.298228917269413 2.53643349382992e-05 NA NA NA hsa-miR-324-5p TGFB2 2.95683728155095 1.32960514360912e-20 -1.19931727990522 0.00330886829654418 miRanda -0.302705023736643 2.71602770897574e-07 NA NA NA hsa-miR-330-3p TGFB2 0.876747334239085 0.00073709016089703 -1.19931727990522 0.00330886829654418 miRNATAP -0.457254743325048 1.06037579343258e-09 NA NA NA hsa-miR-330-5p TGFB2 1.15100069700871 4.85551805046014e-07 -1.19931727990522 0.00330886829654418 miRanda -0.360450971736555 2.54978879561545e-05 NA NA NA hsa-miR-331-5p TGFB2 2.17414714166315 1.54547681391888e-18 -1.19931727990522 0.00330886829654418 miRNATAP -0.239937976385475 0.00244538329219784 NA NA NA hsa-miR-335-3p TGFB2 3.08791651139852 5.31309869723517e-12 -1.19931727990522 0.00330886829654418 mirMAP -0.22185528629857 1.89547879442152e-07 NA NA NA hsa-miR-335-5p TGFB2 1.77247705492746 2.22457658872091e-06 -1.19931727990522 0.00330886829654418 miRNAWalker2_validate -0.252111592909568 1.14412319370904e-06 NA NA NA hsa-miR-33a-3p TGFB2 1.72765312072219 1.51784443453521e-07 -1.19931727990522 0.00330886829654418 MirTarget;mirMAP -0.371056624502634 8.36332661191753e-09 NA NA NA hsa-miR-361-5p TGFB2 0.971859117235239 5.30236555707088e-09 -1.19931727990522 0.00330886829654418 miRNATAP -0.810004741713957 2.97484706931026e-12 NA NA NA hsa-miR-362-3p TGFB2 2.0756816987665 3.89026064579331e-12 -1.19931727990522 0.00330886829654418 miRanda -0.218398256631292 0.00107142313440827 NA NA NA hsa-miR-362-5p TGFB2 1.59303749908759 9.582675908797e-08 -1.19931727990522 0.00330886829654418 MirTarget -0.222085312260446 0.000683040393757458 NA NA NA hsa-miR-429 TGFB2 4.48815175680773 2.44117492218206e-17 -1.19931727990522 0.00330886829654418 miRNATAP -0.354478665199625 1.01610694076904e-25 NA NA NA hsa-miR-454-3p TGFB2 2.47234127820054 1.12878018736016e-21 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.36249217687122 1.13442108861214e-06 NA NA NA hsa-miR-500a-5p TGFB2 1.72110365584658 3.0807246212659e-10 -1.19931727990522 0.00330886829654418 mirMAP -0.230492171637341 0.0012015489418391 NA NA NA hsa-miR-500b-5p TGFB2 1.72172606292185 3.06592098153205e-10 -1.19931727990522 0.00330886829654418 MirTarget -0.231076703558946 0.00116359223151538 NA NA NA hsa-miR-590-3p TGFB2 2.59289455139753 1.03200520972022e-21 -1.19931727990522 0.00330886829654418 mirMAP -0.266142801996328 0.000194961333085026 NA NA NA hsa-miR-590-5p TGFB2 3.18300989862077 2.06813568597893e-26 -1.19931727990522 0.00330886829654418 miRanda;miRNATAP -0.324271064441974 3.01832441227307e-07 NA NA NA hsa-miR-944 TGFB2 2.91186649218281 1.31574753528144e-06 -1.19931727990522 0.00330886829654418 mirMAP -0.180206577855112 5.25792273122866e-08 NA NA NA hsa-let-7a-3p TGFB3 1.42015538786275 7.03375209382654e-13 -1.92191802151593 4.13522948700016e-07 MirTarget -0.381916955776687 3.24138794334629e-05 NA NA NA hsa-miR-10a-5p TGFB3 1.15016989191194 0.00372037233992369 -1.92191802151593 4.13522948700016e-07 miRNAWalker2_validate -0.418366510356312 7.09740564892359e-21 NA NA NA hsa-miR-151a-5p TGFB3 2.32422038747303 2.66226949101065e-18 -1.92191802151593 4.13522948700016e-07 MirTarget -0.825941146129225 4.42377138616228e-42 NA NA NA hsa-miR-26b-3p TGFB3 2.18464160365372 2.11543189388328e-18 -1.92191802151593 4.13522948700016e-07 MirTarget -0.677656521133706 2.42952260248002e-23 NA NA NA hsa-miR-29b-3p TGFB3 1.65828197923813 1.02676780888141e-09 -1.92191802151593 4.13522948700016e-07 miRTarBase -0.399950302957701 1.59835018316921e-09 NA NA NA hsa-miR-590-3p TGFB3 2.59289455139753 1.03200520972022e-21 -1.92191802151593 4.13522948700016e-07 miRanda -0.525346026949253 7.10585127062809e-16 NA NA NA hsa-miR-629-3p TGFB3 2.36570947321815 1.33458201201618e-11 -1.92191802151593 4.13522948700016e-07 MirTarget -0.297411694512799 3.147434114319e-07 NA NA NA hsa-miR-222-3p TP53 0.851783756239071 0.00266783568486918 0.17313275059387 0.48779406985331 miRNAWalker2_validate -0.116904656132339 0.00589565055970469 NA NA NA hsa-miR-139-5p TTK -1.52606598644743 1.20474151350665e-08 3.83401829505147 1.45533766759469e-34 miRanda -0.333191205312856 2.54094089002305e-08 NA NA NA hsa-let-7a-2-3p WEE1 0.0400317820791161 0.91528727576685 -1.40590862047516 1.76830074250163e-11 MirTarget -0.103968226619851 0.000191524800168411 NA NA NA hsa-miR-146b-5p WEE1 1.75587235896724 1.15724631266659e-07 -1.40590862047516 1.76830074250163e-11 miRanda -0.198536384542284 4.87612925573041e-11 NA NA NA hsa-miR-155-5p WEE1 1.20164021433135 0.00086170622431261 -1.40590862047516 1.76830074250163e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.118659419923154 2.97968064982433e-05 NA NA NA hsa-miR-27a-3p WEE1 1.66542180327138 4.93775737894805e-13 -1.40590862047516 1.76830074250163e-11 miRTarBase;MirTarget -0.149688562062089 0.000640862927163398 NA NA NA hsa-miR-369-3p WEE1 0.946781510019564 0.00134850306966842 -1.40590862047516 1.76830074250163e-11 PITA -0.139366594198769 6.54988981832382e-05 NA NA NA hsa-miR-381-3p WEE1 -0.0821432056113931 0.752465205603634 -1.40590862047516 1.76830074250163e-11 MirTarget -0.105461011554337 0.00841254897542568 NA NA NA hsa-miR-424-5p WEE1 1.61930224569578 1.89642549274994e-10 -1.40590862047516 1.76830074250163e-11 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.13494137451283 0.000730263963561331 NA NA NA hsa-miR-655-3p WEE1 0.485339318272148 0.137014658258732 -1.40590862047516 1.76830074250163e-11 MirTarget -0.114086093810412 0.000404108933026744 NA NA NA hsa-miR-26a-5p YWHAE 0.0464832722967259 0.752628386912329 0.514491612368612 0.000180862815548893 miRNAWalker2_validate;miRNATAP -0.174289033994773 0.000159844329938043 NA NA NA hsa-miR-181c-5p YWHAG 1.58587920618301 1.57506918816933e-10 0.156220759818473 0.240477359976782 MirTarget;miRNATAP -0.107876701640243 1.92571385553603e-05 NA NA NA hsa-miR-23b-3p YWHAG -0.251132426825047 0.150200321210792 0.156220759818473 0.240477359976782 MirTarget;miRNATAP -0.117341634709916 0.00162529518912031 NA NA NA hsa-miR-30b-5p YWHAG 0.800822374912712 0.000133601914525413 0.156220759818473 0.240477359976782 miRNATAP -0.132163142680483 1.39361681058969e-05 NA NA NA hsa-miR-30c-5p YWHAG 0.778774633108 0.000285599212429136 0.156220759818473 0.240477359976782 miRNATAP -0.154812531241318 1.64179950979699e-07 NA NA NA hsa-miR-30d-5p YWHAG 0.675423997639582 0.00270618816039773 0.156220759818473 0.240477359976782 miRNATAP -0.132575862878577 2.82953377535704e-06 NA NA NA hsa-miR-30e-5p YWHAG 1.23904909539663 1.35561917122157e-09 0.156220759818473 0.240477359976782 miRNATAP -0.121468680568388 8.32409315658241e-05 NA NA NA hsa-miR-320a YWHAG 0.438165828017084 0.0390159073347133 0.156220759818473 0.240477359976782 PITA;miRanda;miRNATAP -0.100995313053263 0.000877783562361283 NA NA NA hsa-miR-103a-3p YWHAH 1.44083190496858 1.53799939616416e-13 -0.039384739798634 0.787929142314944 miRNAWalker2_validate;MirTarget;miRNATAP -0.161531751525804 4.29697423677565e-06 NA NA NA hsa-miR-107 YWHAH 1.30977326593435 1.30372468603965e-11 -0.039384739798634 0.787929142314944 MirTarget;PITA;miRanda;miRNATAP -0.102725815874759 0.0042174879223718 NA NA NA hsa-miR-28-5p YWHAH 0.230152919654905 0.0742909586754846 -0.039384739798634 0.787929142314944 PITA;miRanda -0.2331357688511 3.2675565751886e-05 NA NA NA hsa-miR-320a YWHAH 0.438165828017084 0.0390159073347133 -0.039384739798634 0.787929142314944 MirTarget;PITA;miRanda -0.222237517506915 1.10194526758971e-11 NA NA NA hsa-miR-330-3p YWHAH 0.876747334239085 0.00073709016089703 -0.039384739798634 0.787929142314944 MirTarget;PITA;miRNATAP -0.16424153759537 6.98871148996655e-10 NA NA NA hsa-miR-361-5p YWHAH 0.971859117235239 5.30236555707088e-09 -0.039384739798634 0.787929142314944 miRanda -0.219428557867208 1.49722216074945e-07 NA NA NA hsa-miR-320a YWHAQ 0.438165828017084 0.0390159073347133 0.144077300408211 0.350876471829226 MirTarget;PITA;miRanda;miRNATAP -0.167079673898302 1.83255873389778e-06 NA NA NA hsa-miR-664a-3p YWHAZ 0.634721925861133 0.00520070178640421 0.309265826104513 0.0711240023820104 mirMAP -0.133473662727781 0.000250895262565301 NA NA NA