miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-139-3p SOX4 -4.00372970427679 4.04839703010847e-39 1.65372042595017 9.13405395935241e-18 miRNATAP -0.222940557242015 6.40208462013327e-17 NA NA NA hsa-miR-140-5p SOX4 0.669142684153918 0.000335928403032308 1.65372042595017 9.13405395935241e-18 PITA;miRanda;miRNATAP -0.137933353108545 0.00649141496018415 27353653 MicroRNA 140 Inhibits Cell Proliferation in Gastric Cancer Cell Line HGC 27 by Suppressing SOX4; SOX4 a predicted target of miR-140 was mutated to verify its regulation by miR-140 and was overexpressed to analyze its function in cell proliferation; miR-140 suppressed SOX4 expression via binding to the 3' untranslated region while the mutant SOX4 could not be regulated; CONCLUSIONS These findings suggest that miR-140 directly inhibits SOX4 which might be one of its mechanisms in suppressing gastric cancer cell proliferation gastric cancer hsa-miR-145-5p SOX4 -1.34926078156437 2.63526538800669e-07 1.65372042595017 9.13405395935241e-18 mirMAP -0.153496372363939 8.57060116762896e-06 NA NA NA hsa-miR-146b-3p SOX4 -0.808296168180355 0.000870284326590347 1.65372042595017 9.13405395935241e-18 PITA -0.285921348400545 7.5663432114746e-15 NA NA NA hsa-miR-30a-3p SOX4 -2.54042202792785 2.9111625410859e-18 1.65372042595017 9.13405395935241e-18 mirMAP -0.23840228788144 6.00382749087123e-16 25572678 Association of SOX4 regulated by tumor suppressor miR 30a with poor prognosis in low grade chondrosarcoma; In an attempt of characterizing SOX4 overexpression mechanism we identified miR-30a as a tumor suppressor that directly targets SOX4 in chondrosarcoma cells; Clinically miR-30a expression was negatively correlated with SOX4 expression in chondrosarcoma cases; In all we identified that SOX4 was oncogenic in chondrosarcoma and negatively regulated by miR-30a in vitro worse prognosis sarcoma hsa-miR-30a-5p SOX4 -0.924084264430689 0.000762030454634728 1.65372042595017 9.13405395935241e-18 miRNATAP -0.258171547494866 1.69825785371651e-15 25572678 Association of SOX4 regulated by tumor suppressor miR 30a with poor prognosis in low grade chondrosarcoma; In an attempt of characterizing SOX4 overexpression mechanism we identified miR-30a as a tumor suppressor that directly targets SOX4 in chondrosarcoma cells; Clinically miR-30a expression was negatively correlated with SOX4 expression in chondrosarcoma cases; In all we identified that SOX4 was oncogenic in chondrosarcoma and negatively regulated by miR-30a in vitro worse prognosis sarcoma hsa-miR-30c-5p SOX4 -0.327319105755825 0.123595832152687 1.65372042595017 9.13405395935241e-18 miRNAWalker2_validate;miRNATAP -0.206790134955389 1.62188498512531e-06 NA NA NA hsa-miR-30d-5p SOX4 -0.920901858717441 3.50898334321668e-05 1.65372042595017 9.13405395935241e-18 miRNATAP -0.123777234036933 0.00262106572215234 NA NA NA hsa-miR-30e-3p SOX4 -0.104420043859122 0.526240453209293 1.65372042595017 9.13405395935241e-18 mirMAP -0.174804686411783 0.00193454168513256 NA NA NA hsa-miR-320a SOX4 -0.961144925954715 1.62478794429204e-08 1.65372042595017 9.13405395935241e-18 PITA;miRanda;miRNATAP -0.161659048109096 0.00258210884873831 NA NA NA hsa-miR-342-5p SOX4 -0.382174669348421 0.0896996965047193 1.65372042595017 9.13405395935241e-18 MirTarget;PITA;miRNATAP -0.145861635449789 0.000359251634277241 NA NA NA