miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-107 ABCA6 1.30977326593435 1.30372468603965e-11 -2.84398142456924 5.64302873515324e-06 miRanda -0.504207580610224 0.00121977843148829 NA NA NA hsa-miR-129-5p ABCA6 -0.524170159980738 0.222582956006346 -2.84398142456924 5.64302873515324e-06 miRanda -0.161418916189837 0.0266865042833933 NA NA NA hsa-miR-338-3p ABCA6 0.453166438193782 0.144583389707558 -2.84398142456924 5.64302873515324e-06 miRanda -0.201794573565555 0.0416809685626442 NA NA NA hsa-miR-342-3p ABCA6 1.49115144672245 1.43879249744621e-07 -2.84398142456924 5.64302873515324e-06 miRanda -0.269936774888453 0.0115946703419867 NA NA NA hsa-miR-362-3p ABCA6 2.0756816987665 3.89026064579331e-12 -2.84398142456924 5.64302873515324e-06 miRanda -0.270452905435217 0.00893758926523235 NA NA NA hsa-miR-421 ABCA6 1.17791565395543 6.78526676976629e-06 -2.84398142456924 5.64302873515324e-06 miRanda -0.234802138178868 0.0446117784989159 NA NA NA hsa-miR-590-3p ABCA6 2.59289455139753 1.03200520972022e-21 -2.84398142456924 5.64302873515324e-06 miRanda -0.473751996892439 1.69511835943361e-05 NA NA NA hsa-miR-590-5p ABCA6 3.18300989862077 2.06813568597893e-26 -2.84398142456924 5.64302873515324e-06 miRanda -0.388100166377753 8.11546778975342e-05 NA NA NA hsa-miR-192-5p ABCA8 2.69002528723195 1.22990188194432e-16 -5.32705416957273 2.60251133083233e-16 miRNAWalker2_validate -0.518674131209807 6.00000484141747e-08 NA NA NA hsa-miR-320b ABCA8 1.55692969039548 1.41071034251915e-08 -5.32705416957273 2.60251133083233e-16 miRanda -0.591607947574358 3.54320225392476e-07 NA NA NA hsa-miR-361-5p ABCA8 0.971859117235239 5.30236555707088e-09 -5.32705416957273 2.60251133083233e-16 miRanda -0.700215208263235 0.000339372036990342 NA NA NA hsa-miR-375 ABCA8 1.13910305294079 0.0512283522214186 -5.32705416957273 2.60251133083233e-16 miRanda -0.152607117310402 0.00620490528331585 NA NA NA hsa-miR-590-3p ABCA8 2.59289455139753 1.03200520972022e-21 -5.32705416957273 2.60251133083233e-16 miRanda -0.88663075391132 1.05212665932823e-14 NA NA NA hsa-miR-155-5p ABCC4 1.20164021433135 0.00086170622431261 -1.54221163650318 6.25853186669673e-06 miRNAWalker2_validate -0.178111992529434 0.000102719766323277 NA NA NA hsa-miR-21-5p ABCD3 2.73773305747971 1.38864982139576e-43 0.143028791773986 0.526090946208158 miRNAWalker2_validate -0.179075525320133 0.000319695642203038 NA NA NA hsa-miR-484 ABHD2 1.81844463411787 1.82951571230938e-15 -0.373262594023986 0.122482606359631 miRNAWalker2_validate -0.117138861542825 0.0184381678720999 NA NA NA hsa-miR-484 ABL1 1.81844463411787 1.82951571230938e-15 -1.32037015957096 1.87647767985755e-18 miRNAWalker2_validate -0.280122803941197 1.14978159043687e-19 NA NA NA hsa-miR-107 ACACB 1.30977326593435 1.30372468603965e-11 -2.92976674861839 3.08008624655325e-19 miRanda -0.551848124497565 2.18332978281919e-11 NA NA NA hsa-miR-148b-3p ACACB 1.97815018171325 6.07715327281595e-26 -2.92976674861839 3.08008624655325e-19 miRNAWalker2_validate -0.678074730816344 4.17804025283029e-17 NA NA NA hsa-miR-324-5p ACACB 2.95683728155095 1.32960514360912e-20 -2.92976674861839 3.08008624655325e-19 miRanda -0.368783635874872 1.97910251599792e-14 NA NA NA hsa-miR-361-5p ACACB 0.971859117235239 5.30236555707088e-09 -2.92976674861839 3.08008624655325e-19 miRanda -0.481330512186425 9.57302810482021e-07 NA NA NA hsa-miR-455-5p ACACB 2.2582442061694 1.43472128037398e-13 -2.92976674861839 3.08008624655325e-19 miRanda -0.395559920962405 9.17414166655577e-15 NA NA NA hsa-miR-542-3p ACACB 1.18832665895751 1.98700670691565e-07 -2.92976674861839 3.08008624655325e-19 miRanda -0.263406689228422 0.000234022271601596 NA NA NA hsa-miR-28-5p ACAT1 0.230152919654905 0.0742909586754846 -1.05404468189546 3.5026896380006e-07 miRanda -0.311967436975737 0.000113285987499499 NA NA NA hsa-miR-484 ACTA2 1.81844463411787 1.82951571230938e-15 -3.49662779814752 2.35094195114616e-15 miRNAWalker2_validate -0.907423525236774 1.84016526461911e-24 NA NA NA hsa-miR-484 ACTB 1.81844463411787 1.82951571230938e-15 -0.535801422758441 0.000459314156252532 miRNAWalker2_validate -0.170781380322726 4.03541322659563e-08 NA NA NA hsa-miR-148a-3p ACVR1 1.26728238710376 2.52325607402829e-06 -0.440784615093559 0.011428168867015 miRNAWalker2_validate;miRTarBase -0.110862668181035 0.000345005837807225 NA NA NA hsa-miR-28-5p ADA 0.230152919654905 0.0742909586754846 0.714672894727359 0.044749204408525 miRanda -0.550850219903374 6.08888668630002e-05 NA NA NA hsa-miR-155-5p ADAM10 1.20164021433135 0.00086170622431261 0.673280532227232 0.00766169587340031 miRNAWalker2_validate -0.108121655059448 0.00134605620037911 NA NA NA hsa-miR-28-5p ADAMTSL1 0.230152919654905 0.0742909586754846 -2.52324986280955 4.56844687807366e-08 miRanda -0.39101267156186 0.0317474979617961 NA NA NA hsa-miR-148a-3p ADARB1 1.26728238710376 2.52325607402829e-06 -1.92780468757935 3.75403498492562e-10 miRNAWalker2_validate -0.307980450750681 2.53408007458827e-08 NA NA NA hsa-miR-375 ADARB1 1.13910305294079 0.0512283522214186 -1.92780468757935 3.75403498492562e-10 miRanda -0.10460325602736 5.06051672095175e-05 NA NA NA hsa-miR-429 ADH1B 4.48815175680773 2.44117492218206e-17 -7.88519628035832 1.79366682246271e-19 miRanda -0.427527412500748 6.48580235512397e-08 NA NA NA hsa-miR-491-5p ADH1B 0.615770352820862 0.0418295628761654 -7.88519628035832 1.79366682246271e-19 miRanda -0.480026459140734 0.0022316509937532 NA NA NA hsa-miR-590-3p ADH1B 2.59289455139753 1.03200520972022e-21 -7.88519628035832 1.79366682246271e-19 miRanda -1.25947283524287 3.95919758305925e-16 NA NA NA hsa-miR-590-3p ADH1C 2.59289455139753 1.03200520972022e-21 -3.38279487552069 7.48195946978741e-05 miRanda -0.455699712305694 0.00247187744263321 NA NA NA hsa-miR-129-5p ADIPOQ -0.524170159980738 0.222582956006346 -5.01753453319526 8.78927998691923e-10 miRanda -0.209918908206811 0.0289798891601082 NA NA NA hsa-miR-320a ADIPOQ 0.438165828017084 0.0390159073347133 -5.01753453319526 8.78927998691923e-10 miRanda -0.923001378856107 1.22308327236842e-06 NA NA NA hsa-miR-320b ADIPOQ 1.55692969039548 1.41071034251915e-08 -5.01753453319526 8.78927998691923e-10 miRanda -1.20342270708804 7.34911524684501e-18 NA NA NA hsa-miR-326 ADIPOQ 0.715313016136042 0.0610265683213359 -5.01753453319526 8.78927998691923e-10 miRanda -0.242212587908046 0.0229561936729908 NA NA NA hsa-miR-330-5p ADIPOQ 1.15100069700871 4.85551805046014e-07 -5.01753453319526 8.78927998691923e-10 miRanda -0.715039874091121 4.27442064346828e-05 NA NA NA hsa-miR-339-5p ADIPOQ 2.68710938429893 3.03134080808154e-16 -5.01753453319526 8.78927998691923e-10 miRanda -0.537275098279257 5.00407128928049e-06 NA NA NA hsa-miR-429 ADIPOQ 4.48815175680773 2.44117492218206e-17 -5.01753453319526 8.78927998691923e-10 miRanda -0.664144192376016 1.6471294926152e-21 NA NA NA hsa-miR-590-3p ADIPOQ 2.59289455139753 1.03200520972022e-21 -5.01753453319526 8.78927998691923e-10 miRanda -1.11500146405354 3.56898076382927e-15 NA NA NA hsa-miR-21-5p ADNP 2.73773305747971 1.38864982139576e-43 0.22779421586467 0.123598070076511 miRNAWalker2_validate -0.10219910738892 0.00174793661240588 NA NA NA hsa-miR-28-5p AFF4 0.230152919654905 0.0742909586754846 -0.822203744881362 6.4795364730311e-08 miRanda -0.15969701084228 0.00747121430134359 NA NA NA hsa-miR-155-5p AGL 1.20164021433135 0.00086170622431261 -0.673875871821132 6.19363648310283e-05 miRNAWalker2_validate -0.171272872592759 5.11559609965395e-15 NA NA NA hsa-miR-155-5p AGTR1 1.20164021433135 0.00086170622431261 -4.49116315334224 1.0213817951258e-14 miRNAWalker2_validate;miRTarBase -0.184115845721851 0.0218395984242599 22525818 MicroRNA-155 miR-155 is one of the micro RNAs miRNA most consistently involved in neoplastic diseases and it is known to repress the angiotensin II type 1 receptor AGTR1; The aim of the present study was to evaluate the expressions of miR-155 and AGTR1 and to clarify the potential efficacy of anti-miR-155 alone and in combination with AGTR1 blocker losartan in endometrial cancers; Expressions of miR-155 and AGTR1 were evaluated using real-time PCR and immunohistochemistry; miR-155 was over-expressed and AGTR1 was underexpressed in endometrial carcinoma tissues; We checked that abolishing the function of miR-155 and AGTR1 by anti-miR-155 or losartan inhibited cell survival of endometrial carcinoma cells respectively and furthermore combined treatment showed synergistic effects; In this study we characterized the expressions of miR-155 and AGTR1 in endometrial tissues; The combined treatment with anti-miR-155 and losartan has a synergistic antiproliferative effect and an improved understanding is required to clarify whether miR-155 and AGTR1 can be used as a novel therapeutic target in endometrial cancer poor survival endometrial cancer hsa-miR-484 AHDC1 1.81844463411787 1.82951571230938e-15 -0.685365098696008 5.93650539556809e-05 miRNAWalker2_validate -0.182697245190463 1.62844181990801e-07 NA NA NA hsa-miR-28-5p AHNAK 0.230152919654905 0.0742909586754846 -1.65511086697194 9.68769934496862e-10 miRanda -0.441878180593099 3.26861475831162e-05 NA NA NA hsa-miR-183-5p AKAP12 4.19757025992371 4.79612296318304e-26 -2.95436381376503 3.32936837316014e-12 miRNAWalker2_validate;miRTarBase -0.328619102859084 1.49260667802573e-11 NA NA NA hsa-miR-28-5p AKAP13 0.230152919654905 0.0742909586754846 -1.14731602724292 2.3511548631978e-13 miRanda -0.211512094397884 0.000670892553419229 NA NA NA hsa-miR-484 AKAP13 1.81844463411787 1.82951571230938e-15 -1.14731602724292 2.3511548631978e-13 miRNAWalker2_validate -0.337292056310372 1.60221401990181e-27 NA NA NA hsa-miR-28-5p AKAP2 0.230152919654905 0.0742909586754846 -2.50607126147978 8.18180385648383e-05 miRanda -0.635987909791208 0.0105364000825376 NA NA NA hsa-miR-21-5p AKAP9 2.73773305747971 1.38864982139576e-43 -0.0499704758575863 0.75799897571907 miRNAWalker2_validate -0.139988018661555 8.62867311282137e-05 NA NA NA hsa-miR-28-5p AKIRIN1 0.230152919654905 0.0742909586754846 -0.65052767150198 6.92186905420829e-06 miRanda -0.162637387737928 0.00394435524691894 NA NA NA hsa-miR-155-5p AKR1C3 1.20164021433135 0.00086170622431261 -0.317119520201889 0.596335930648703 miRNAWalker2_validate -0.281687786392172 0.000404364477803552 NA NA NA hsa-miR-15a-5p AKT3 2.34669284378787 1.69544424500258e-23 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase -0.653282073492048 2.38693369892811e-22 NA NA NA hsa-miR-142-3p ALDH1A2 2.75247908790621 1.45636065474764e-12 -1.89198756431823 0.00169530627826683 miRanda -0.399127456496986 3.35696628955967e-08 NA NA NA hsa-miR-155-5p ALDH1A2 1.20164021433135 0.00086170622431261 -1.89198756431823 0.00169530627826683 miRNAWalker2_validate -0.416548783710603 1.87656284309432e-07 NA NA NA hsa-miR-193b-3p ALDH1A2 2.25711804611899 4.1940744806631e-14 -1.89198756431823 0.00169530627826683 miRNAWalker2_validate -0.432500904036382 4.68958386140963e-06 NA NA NA hsa-miR-455-5p ALDH1A2 2.2582442061694 1.43472128037398e-13 -1.89198756431823 0.00169530627826683 miRanda -0.473682969798717 2.7913824854662e-07 NA NA NA hsa-miR-28-5p ALDH3A2 0.230152919654905 0.0742909586754846 -0.630157951471592 0.00987498986632215 miRanda -0.281767853409434 0.00292854800458774 NA NA NA hsa-miR-155-5p ALDH5A1 1.20164021433135 0.00086170622431261 0.210887074299285 0.50454240222805 miRNAWalker2_validate -0.190797954122413 5.01583197680562e-06 NA NA NA hsa-miR-28-5p ALG9 0.230152919654905 0.0742909586754846 -0.292024961321253 0.00937202194419776 miRanda -0.141623380581027 0.00107179423616697 NA NA NA hsa-miR-21-5p ALMS1 2.73773305747971 1.38864982139576e-43 -0.119961232610692 0.435671265853671 miRNAWalker2_validate -0.141388822016219 2.85523843523223e-05 NA NA NA hsa-miR-146b-5p AMIGO2 1.75587235896724 1.15724631266659e-07 0.861093975875986 0.0166400435099222 miRanda -0.21094129187939 4.36650275912542e-05 NA NA NA hsa-miR-155-5p AMIGO2 1.20164021433135 0.00086170622431261 0.861093975875986 0.0166400435099222 miRNAWalker2_validate -0.200526423862953 2.75037556576149e-05 NA NA NA hsa-miR-484 AMOTL1 1.81844463411787 1.82951571230938e-15 -1.62373117026861 1.24108045740137e-08 miRNAWalker2_validate -0.488945258295715 1.67920121006645e-17 NA NA NA hsa-miR-28-5p ANGEL1 0.230152919654905 0.0742909586754846 0.182251258727819 0.173384905842179 miRanda -0.20481962709587 6.68560677467282e-05 NA NA NA hsa-miR-28-5p ANKRD37 0.230152919654905 0.0742909586754846 -0.996932318707632 0.000370936218356683 miRanda -0.222426518841412 0.0418935221939909 NA NA NA hsa-miR-21-5p ANKRD46 2.73773305747971 1.38864982139576e-43 -0.0019816925059164 0.992610130492932 miRNAWalker2_validate;miRTarBase -0.261734867623662 2.03114853550794e-08 21219636 Knockdown of miR-21 significantly increased the expression of ANKRD46 at both mRNA and protein levels; ANKRD46 is newly identified as a direct target of miR-21 in BC breast cancer hsa-miR-28-5p ANXA1 0.230152919654905 0.0742909586754846 -1.02035370696444 0.0175652725579933 miRanda -0.884879866676187 7.8129951450715e-08 NA NA NA hsa-miR-92b-3p AP1B1 1.20409245530001 3.41055816361655e-06 0.510952303670897 0.000624787203089951 miRNAWalker2_validate -0.119584921240096 1.43511913791619e-05 NA NA NA hsa-miR-28-5p AP2A2 0.230152919654905 0.0742909586754846 -0.288132684900019 0.0110484182124217 miRanda -0.207651004471232 1.67845566363123e-06 NA NA NA hsa-miR-28-5p AP3S1 0.230152919654905 0.0742909586754846 -0.0598332547733529 0.689135327339356 miRanda -0.266818306399135 3.08705299902844e-06 NA NA NA hsa-miR-28-5p AP4E1 0.230152919654905 0.0742909586754846 -0.36893262862062 0.00476279718838015 miRanda -0.211617688476252 2.55890350423767e-05 NA NA NA hsa-miR-15b-5p AP4S1 1.57112623124278 9.14247846750597e-13 -0.601701486357856 0.000550679634349202 miRNAWalker2_validate -0.12822370001197 0.000640446783304667 NA NA NA hsa-miR-148a-3p APC 1.26728238710376 2.52325607402829e-06 -0.603984431450045 0.000122196213200349 miRNAWalker2_validate -0.118159804157767 2.41472154629156e-05 NA NA NA hsa-miR-21-5p APC 2.73773305747971 1.38864982139576e-43 -0.603984431450045 0.000122196213200349 miRNAWalker2_validate -0.210735008738127 9.09045679037576e-10 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-375 APOB 1.13910305294079 0.0512283522214186 -2.14962185286247 0.000603715529944363 miRanda -0.149996878730414 0.00392340483942411 NA NA NA hsa-miR-142-3p APOD 2.75247908790621 1.45636065474764e-12 -3.11121286286979 1.35689773681701e-06 miRanda -0.304706015669876 0.000104933497671958 NA NA NA hsa-miR-21-5p APOLD1 2.73773305747971 1.38864982139576e-43 -2.61565377645349 1.36771501780805e-19 miRNAWalker2_validate -0.530820925510853 2.50933900904465e-16 NA NA NA hsa-miR-92b-3p APOLD1 1.20409245530001 3.41055816361655e-06 -2.61565377645349 1.36771501780805e-19 miRNAWalker2_validate -0.14102116611919 0.0119455441912107 NA NA NA hsa-miR-15a-5p APP 2.34669284378787 1.69544424500258e-23 -0.400687156011365 0.0428770191036906 miRNAWalker2_validate -0.222175252200734 5.66843852411498e-09 NA NA NA hsa-miR-484 APP 1.81844463411787 1.82951571230938e-15 -0.400687156011365 0.0428770191036906 miRNAWalker2_validate -0.1865854432416 3.71493886316962e-06 NA NA NA hsa-miR-21-5p APPL1 2.73773305747971 1.38864982139576e-43 -0.257462944814079 0.0623645905506928 miRNAWalker2_validate -0.152358470013772 4.58842287173491e-07 NA NA NA hsa-miR-429 AREG 4.48815175680773 2.44117492218206e-17 -1.82108928709305 0.00454782507843903 miRanda -0.192425822189951 0.000625024329953195 NA NA NA hsa-miR-155-5p ARFIP1 1.20164021433135 0.00086170622431261 -0.250233482227553 0.054434841978985 miRNAWalker2_validate -0.107328882883144 2.58263937607701e-10 NA NA NA hsa-miR-155-5p ARGLU1 1.20164021433135 0.00086170622431261 0.365391062508523 0.053540969925008 miRNAWalker2_validate -0.122013382782366 1.06115726586765e-06 NA NA NA hsa-miR-28-5p ARHGEF10 0.230152919654905 0.0742909586754846 -1.15130581039586 6.65689418065909e-06 miRanda -0.266822727104357 0.00764315003705235 NA NA NA hsa-miR-21-5p ARHGEF12 2.73773305747971 1.38864982139576e-43 -0.641257258515214 3.63829977815245e-05 miRNAWalker2_validate -0.234096931756046 4.48344286847499e-12 NA NA NA hsa-miR-155-5p ARID2 1.20164021433135 0.00086170622431261 -0.0508683211857965 0.733019791870527 miRNAWalker2_validate;miRTarBase -0.159200181973594 8.14481797377834e-17 27035278 MicroRNA 155 promotes tumor growth of human hepatocellular carcinoma by targeting ARID2 liver cancer hsa-miR-21-5p ARID4A 2.73773305747971 1.38864982139576e-43 -0.759103114725627 2.29548752570899e-07 miRNAWalker2_validate -0.287659935212023 6.23907030701265e-20 NA NA NA hsa-miR-429 ARL4A 4.48815175680773 2.44117492218206e-17 -0.615829174715148 0.0152477484975196 miRanda -0.10585064892045 1.57256661939587e-06 NA NA NA hsa-miR-28-5p ARMC9 0.230152919654905 0.0742909586754846 -0.174093498391943 0.435015689310142 miRanda -0.243797363757469 0.00467472161246196 NA NA NA hsa-miR-21-5p ARMCX3 2.73773305747971 1.38864982139576e-43 -0.356068609236653 0.0547593463291297 miRNAWalker2_validate -0.113858480505855 0.00555448827695556 NA NA NA hsa-miR-28-5p ASCC3 0.230152919654905 0.0742909586754846 -0.0540147101301995 0.752334599008416 miRanda -0.32618645984967 6.10344125655069e-07 NA NA NA hsa-miR-21-5p ASRGL1 2.73773305747971 1.38864982139576e-43 -0.330550534287443 0.414309762221691 miRNAWalker2_validate -0.205844368354248 0.0219522939153064 NA NA NA hsa-miR-15a-5p ASXL2 2.34669284378787 1.69544424500258e-23 -0.51451006623666 0.0933931654074008 miRNAWalker2_validate -0.261857966815704 1.13116285012721e-05 NA NA NA hsa-miR-21-5p ATAD2B 2.73773305747971 1.38864982139576e-43 0.213562537647375 0.161268370367734 miRNAWalker2_validate -0.10540783278728 0.00173283298106866 NA NA NA hsa-miR-15a-5p ATF2 2.34669284378787 1.69544424500258e-23 -0.360334142061557 0.0913687862766104 miRNAWalker2_validate -0.170687494407351 3.95479356045233e-05 NA NA NA hsa-miR-484 ATP2A2 1.81844463411787 1.82951571230938e-15 -0.397734954696507 0.0122519173120377 miRNAWalker2_validate -0.106100217746242 0.00112296032542829 NA NA NA hsa-miR-21-5p ATP2B4 2.73773305747971 1.38864982139576e-43 -1.72037479984404 8.20260471374597e-10 miRNAWalker2_validate -0.325404212404046 2.08547343507493e-07 NA NA NA hsa-miR-28-5p ATP8A1 0.230152919654905 0.0742909586754846 -1.47752118217688 7.63290299845151e-05 miRanda -0.411547473146604 0.00476607250917131 NA NA NA hsa-miR-28-5p ATP8B2 0.230152919654905 0.0742909586754846 -1.89041258448176 1.15911506468727e-08 miRanda -0.401344007186825 0.00210018399381534 NA NA NA hsa-miR-21-5p ATRX 2.73773305747971 1.38864982139576e-43 -0.652171803167016 1.3992777516498e-05 miRNAWalker2_validate -0.21407399728493 6.99297046692009e-11 NA NA NA hsa-miR-28-5p ATXN1 0.230152919654905 0.0742909586754846 -1.5104377454496 2.95939614593378e-08 miRanda -0.292953765005276 0.0063174830338883 NA NA NA hsa-miR-28-5p ATXN3 0.230152919654905 0.0742909586754846 -0.207346364694122 0.0513249613550925 miRanda -0.129802349098897 0.00150372925832323 NA NA NA hsa-miR-21-5p AUTS2 2.73773305747971 1.38864982139576e-43 -0.700243024892347 0.0585017200367816 miRNAWalker2_validate -0.250562299157904 0.00226129786653548 NA NA NA hsa-miR-15b-5p AXIN2 1.57112623124278 9.14247846750597e-13 -1.6986287186272 5.56904404371908e-05 miRTarBase -0.560514974548682 4.5066035821598e-10 NA NA NA hsa-miR-375 AXL 1.13910305294079 0.0512283522214186 -1.77455438864263 3.15266913146372e-06 miRNAWalker2_validate -0.161791355660634 2.63652357221143e-07 NA NA NA hsa-miR-21-5p B3GALNT1 2.73773305747971 1.38864982139576e-43 0.192323346909089 0.468896617203748 miRNAWalker2_validate -0.159506452389134 0.00666938924413397 NA NA NA hsa-miR-15a-5p BACE1 2.34669284378787 1.69544424500258e-23 -0.723461241968299 0.00095792938893533 miRNAWalker2_validate -0.299553781085055 9.69824626313551e-13 NA NA NA hsa-miR-375 BATF2 1.13910305294079 0.0512283522214186 0.0630197357999309 0.892032016329026 miRNAWalker2_validate -0.100051507978566 0.00897106290771338 NA NA NA hsa-miR-107 BBOX1 1.30977326593435 1.30372468603965e-11 0.0689298854546481 0.91587459358169 miRanda -0.523712711627824 0.00109481572090172 NA NA NA hsa-miR-28-5p BBX 0.230152919654905 0.0742909586754846 -0.507481905404495 0.00131215317769605 miRanda -0.12417170466079 0.0432123172117192 NA NA NA hsa-miR-484 BBX 1.81844463411787 1.82951571230938e-15 -0.507481905404495 0.00131215317769605 miRNAWalker2_validate -0.172873666352177 7.36359345579424e-08 NA NA NA hsa-miR-15a-5p BCL2 2.34669284378787 1.69544424500258e-23 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.391979588821952 1.08722628903108e-12 25594541;26915294;18931683;25623762;22335947 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 ;poor survival;;drug resistance; breast cancer;lung cancer;prostate cancer;colon cancer;breast cancer hsa-miR-15b-5p BCL2 1.57112623124278 9.14247846750597e-13 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.256427911729671 3.30685638311642e-05 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-200b-3p BCL2 3.78235093249346 3.18343003239465e-14 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.147905318391455 3.02424877197984e-08 NA NA NA hsa-miR-21-5p BCL2 2.73773305747971 1.38864982139576e-43 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.366618885310627 5.78881699391161e-09 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-155-5p BCL6 1.20164021433135 0.00086170622431261 -0.560948107851636 0.00742755314303511 miRNAWalker2_validate;miRTarBase -0.154245699960855 2.37177656808363e-08 23169640 We show that Bcl6 is indirectly regulated by miR-155 through Mxd1/Mad1 up-regulation; Interestingly we found that miR-155 directly targets HDAC4 a corepressor partner of BCL6; Meta-analysis of the diffuse large B-cell lymphoma patient microarray data showed that miR-155 expression is inversely correlated with Bcl6 and Hdac4; Hence this study provides a better understanding of how miR-155 causes disruption of the BCL6 transcriptional machinery that leads to up-regulation of the survival and proliferation genes in miR-155-induced leukemias poor survival B cell lymphoma hsa-miR-21-5p BCL6 2.73773305747971 1.38864982139576e-43 -0.560948107851636 0.00742755314303511 miRNAWalker2_validate -0.144539023027501 0.00187248146213644 NA NA NA hsa-miR-28-5p BEGAIN 0.230152919654905 0.0742909586754846 -1.3714437712631 0.000707505293237067 miRanda -0.367967240502951 0.0198232658738655 NA NA NA hsa-miR-15b-5p BEX1 1.57112623124278 9.14247846750597e-13 -2.41284812815801 2.57572223150298e-06 miRNAWalker2_validate -0.589132379417086 9.78868604780628e-08 NA NA NA hsa-miR-28-5p BGN 0.230152919654905 0.0742909586754846 0.606941335048649 0.112008541607815 miRanda -0.311498502665485 0.0356318559770034 NA NA NA hsa-miR-28-5p BHLHE40 0.230152919654905 0.0742909586754846 -0.754044759968888 0.00869378402058291 miRanda -0.401531461361551 0.000306125608170069 NA NA NA hsa-miR-28-5p BICC1 0.230152919654905 0.0742909586754846 -1.47372919074758 0.0139332319489531 miRanda -0.598558005186413 0.0101758721012203 NA NA NA hsa-miR-21-5p BMPR2 2.73773305747971 1.38864982139576e-43 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;miRTarBase -0.131652287320736 3.08798777679263e-05 NA NA NA hsa-miR-21-5p BOC 2.73773305747971 1.38864982139576e-43 -2.87063012014339 2.27360984062983e-13 miRNAWalker2_validate -0.408119245124809 4.27776242697588e-06 NA NA NA hsa-miR-148a-3p BTBD3 1.26728238710376 2.52325607402829e-06 -0.598938891556394 0.00457024006889484 miRNAWalker2_validate -0.121512208017375 0.00125527579760037 NA NA NA hsa-miR-21-5p BTBD3 2.73773305747971 1.38864982139576e-43 -0.598938891556394 0.00457024006889484 miRNAWalker2_validate -0.262539499882604 1.38052420496728e-08 NA NA NA hsa-miR-21-5p BTBD7 2.73773305747971 1.38864982139576e-43 -0.301289747681754 0.0314352639468306 miRNAWalker2_validate -0.165462120896455 6.28910030586669e-08 NA NA NA hsa-miR-28-5p BTG1 0.230152919654905 0.0742909586754846 -0.801786909425222 2.46834094854793e-05 miRanda -0.177147660781496 0.0170706621548159 NA NA NA hsa-miR-484 BTG1 1.81844463411787 1.82951571230938e-15 -0.801786909425222 2.46834094854793e-05 miRNAWalker2_validate -0.131749460473984 0.000797244299060224 NA NA NA hsa-miR-21-5p BTG2 2.73773305747971 1.38864982139576e-43 -2.39277835287452 4.60249921018368e-12 miRNAWalker2_validate;miRTarBase -0.732585470950547 1.25280952744168e-22 24821435 miR 21 regulates N methyl N nitro N' nitrosoguanidine induced gastric tumorigenesis by targeting FASLG and BTG2 tumorigenesis gastric cancer hsa-miR-193a-3p C7 1.60460546928078 2.86169793322984e-07 -6.75966420952687 3.8710394841327e-15 miRanda -0.363116656633425 0.0076827176495653 NA NA NA hsa-miR-330-5p C7 1.15100069700871 4.85551805046014e-07 -6.75966420952687 3.8710394841327e-15 miRanda -0.842935116908379 5.70164260427111e-06 NA NA NA hsa-miR-375 C7 1.13910305294079 0.0512283522214186 -6.75966420952687 3.8710394841327e-15 miRanda -0.202526362276239 0.00587349569014236 NA NA NA hsa-miR-421 C7 1.17791565395543 6.78526676976629e-06 -6.75966420952687 3.8710394841327e-15 miRanda -0.76957752383284 2.22459971124412e-06 NA NA NA hsa-miR-590-3p C7 2.59289455139753 1.03200520972022e-21 -6.75966420952687 3.8710394841327e-15 miRanda -1.30058586802353 3.93678964014154e-18 NA NA NA hsa-miR-590-5p C7 3.18300989862077 2.06813568597893e-26 -6.75966420952687 3.8710394841327e-15 miRanda -1.23279098835341 1.78358029886167e-20 NA NA NA hsa-miR-155-5p CAB39L 1.20164021433135 0.00086170622431261 -1.32713099101099 0.0016286153077432 miRNAWalker2_validate -0.465068952849233 1.19895211489865e-17 NA NA NA hsa-miR-342-3p CAB39L 1.49115144672245 1.43879249744621e-07 -1.32713099101099 0.0016286153077432 miRanda -0.345811625519967 9.98604734821319e-07 NA NA NA hsa-miR-362-3p CAB39L 2.0756816987665 3.89026064579331e-12 -1.32713099101099 0.0016286153077432 miRanda -0.233526737377569 0.000701131740966757 NA NA NA hsa-miR-590-3p CAB39L 2.59289455139753 1.03200520972022e-21 -1.32713099101099 0.0016286153077432 miRanda -0.271432757362025 0.000233995683821118 NA NA NA hsa-miR-590-5p CAB39L 3.18300989862077 2.06813568597893e-26 -1.32713099101099 0.0016286153077432 miRanda -0.216240907453537 0.00104450011172972 NA NA NA hsa-miR-28-5p CACNA2D3 0.230152919654905 0.0742909586754846 -1.0505233677206 0.0190043772864545 miRanda -0.360584111366487 0.0384796494904584 NA NA NA hsa-miR-15a-5p CADM1 2.34669284378787 1.69544424500258e-23 -1.1928516537365 0.0125125326037739 miRNAWalker2_validate;miRTarBase -0.26989087540155 0.00398839838276791 NA NA NA hsa-miR-15a-5p CALD1 2.34669284378787 1.69544424500258e-23 -2.4663455628847 1.26294093745705e-11 miRNAWalker2_validate -0.848396976933768 1.00350791777091e-36 NA NA NA hsa-miR-21-5p CALD1 2.73773305747971 1.38864982139576e-43 -2.4663455628847 1.26294093745705e-11 miRNAWalker2_validate -0.190519103888097 0.0216334478060868 NA NA NA hsa-miR-484 CAMK2D 1.81844463411787 1.82951571230938e-15 -0.889394756636849 2.56115555479955e-05 miRNAWalker2_validate -0.183122516221665 2.57365395358782e-05 NA NA NA hsa-miR-28-5p CANT1 0.230152919654905 0.0742909586754846 0.710641186424899 3.29350773535793e-07 miRanda -0.159331185995894 0.00342252136591696 NA NA NA hsa-miR-320a CAPN6 0.438165828017084 0.0390159073347133 -3.47799832819863 8.37155036573641e-07 miRanda -0.460949232764687 0.00502716106760165 NA NA NA hsa-miR-320b CAPN6 1.55692969039548 1.41071034251915e-08 -3.47799832819863 8.37155036573641e-07 miRanda -0.479920229638359 0.000106148969965956 NA NA NA hsa-miR-324-5p CAPN6 2.95683728155095 1.32960514360912e-20 -3.47799832819863 8.37155036573641e-07 miRanda -0.53795048661307 1.6249409120697e-07 NA NA NA hsa-miR-330-5p CAPN6 1.15100069700871 4.85551805046014e-07 -3.47799832819863 8.37155036573641e-07 miRanda -0.562539674020411 0.000172643269832726 NA NA NA hsa-miR-361-5p CAPN6 0.971859117235239 5.30236555707088e-09 -3.47799832819863 8.37155036573641e-07 miRanda -0.552954814210022 0.00773847573197441 NA NA NA hsa-miR-429 CAPN6 4.48815175680773 2.44117492218206e-17 -3.47799832819863 8.37155036573641e-07 miRanda -0.32223823617948 1.94181542975417e-07 NA NA NA hsa-miR-28-5p CAPRIN1 0.230152919654905 0.0742909586754846 0.135551352083136 0.294827050774613 miRanda -0.181785622595973 0.000253443626941168 NA NA NA hsa-miR-28-5p CASP4 0.230152919654905 0.0742909586754846 0.0955450731362726 0.690472782335497 miRanda -0.276740246940674 0.0028255452903518 NA NA NA hsa-miR-103a-3p CAV1 1.44083190496858 1.53799939616416e-13 -2.01974798120702 2.54118019912082e-06 miRNAWalker2_validate;miRTarBase -1.01798187435656 2.14579195256663e-24 NA NA NA hsa-miR-26b-5p CAV1 0.885393662798425 3.2116297961629e-06 -2.01974798120702 2.54118019912082e-06 miRNAWalker2_validate -0.36463539634671 0.000957068500389678 NA NA NA hsa-miR-28-5p CAV1 0.230152919654905 0.0742909586754846 -2.01974798120702 2.54118019912082e-06 miRanda -0.708604705212145 2.27026150117327e-05 NA NA NA hsa-miR-320a CAV1 0.438165828017084 0.0390159073347133 -2.01974798120702 2.54118019912082e-06 miRanda -0.553942456295331 1.7911261201619e-08 NA NA NA hsa-miR-320b CAV1 1.55692969039548 1.41071034251915e-08 -2.01974798120702 2.54118019912082e-06 miRanda -0.407296773163367 4.61472588892388e-08 NA NA NA hsa-miR-361-5p CAV1 0.971859117235239 5.30236555707088e-09 -2.01974798120702 2.54118019912082e-06 miRanda -0.99953987715543 2.13789541542839e-16 NA NA NA hsa-miR-421 CAV1 1.17791565395543 6.78526676976629e-06 -2.01974798120702 2.54118019912082e-06 miRanda -0.22406146437789 0.00508853793323396 NA NA NA hsa-miR-28-5p CAV2 0.230152919654905 0.0742909586754846 -0.856216400893455 0.0106141298426981 miRanda -0.572967793704766 9.21331626180463e-06 NA NA NA hsa-miR-484 CBR1 1.81844463411787 1.82951571230938e-15 0.110296482735456 0.628735101257253 miRNAWalker2_validate -0.100499302225022 0.032026373312882 NA NA NA hsa-miR-155-5p CBR4 1.20164021433135 0.00086170622431261 -0.139831965618233 0.458625233441578 miRNAWalker2_validate -0.215564233787755 3.44780254378397e-19 NA NA NA hsa-miR-484 CBX6 1.81844463411787 1.82951571230938e-15 -1.53953176885359 2.83932741324751e-07 miRNAWalker2_validate -0.268756245190014 1.50515681596275e-05 NA NA NA hsa-miR-484 CCDC136 1.81844463411787 1.82951571230938e-15 -2.11240821898235 2.70970337189754e-08 miRNAWalker2_validate -0.334867056256711 2.22444912301559e-05 NA NA NA hsa-miR-375 CCDC80 1.13910305294079 0.0512283522214186 -3.33072052510427 2.4668324543934e-10 miRanda -0.186492718775648 2.39336074422193e-05 NA NA NA hsa-miR-28-5p CCDC87 0.230152919654905 0.0742909586754846 0.073215876404781 0.796853721995104 miRanda -0.222330425081094 0.0436762104767878 NA NA NA hsa-miR-15b-5p CCND1 1.57112623124278 9.14247846750597e-13 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase -0.2743592470705 0.00190316455907807 NA NA NA hsa-miR-15a-5p CCND2 2.34669284378787 1.69544424500258e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase -0.558385276567589 5.78612617845985e-14 NA NA NA hsa-miR-21-5p CCNG1 2.73773305747971 1.38864982139576e-43 -0.630675935972558 0.000400486995429734 miRNAWalker2_validate -0.334984360503205 1.41305076025776e-18 NA NA NA hsa-miR-28-5p CD209 0.230152919654905 0.0742909586754846 -1.78312650459774 0.000348543978778311 miRanda -0.558963578196841 0.0040232964265425 NA NA NA hsa-miR-28-5p CD300C 0.230152919654905 0.0742909586754846 -0.647640712175003 0.15381917288987 miRanda -0.487735882510359 0.00556372040321537 NA NA NA hsa-miR-28-5p CD300LF 0.230152919654905 0.0742909586754846 0.49406801961588 0.244363420441934 miRanda -0.405936805774603 0.0135941147882586 NA NA NA hsa-miR-26b-5p CD36 0.885393662798425 3.2116297961629e-06 -1.94192276042899 0.00140729779446689 miRNAWalker2_validate -0.567476358035865 0.000253755827367307 NA NA NA hsa-miR-361-5p CD36 0.971859117235239 5.30236555707088e-09 -1.94192276042899 0.00140729779446689 miRanda -0.563463608053883 0.00146037100071986 NA NA NA hsa-miR-590-3p CD36 2.59289455139753 1.03200520972022e-21 -1.94192276042899 0.00140729779446689 miRanda -0.314283897255632 0.00327377425697286 NA NA NA hsa-miR-15b-5p CD44 1.57112623124278 9.14247846750597e-13 -0.796526651909205 0.0427559627960533 miRNAWalker2_validate -0.447526802339096 9.12256284724987e-08 NA NA NA hsa-miR-28-5p CD44 0.230152919654905 0.0742909586754846 -0.796526651909205 0.0427559627960533 miRanda -0.917439364317955 9.13749604227941e-10 NA NA NA hsa-miR-28-5p CD47 0.230152919654905 0.0742909586754846 -0.164318188512451 0.480797231316326 miRanda -0.350017724326003 9.53457323530239e-05 NA NA NA hsa-miR-484 CDC37L1 1.81844463411787 1.82951571230938e-15 -1.07559774960025 1.69206334535971e-12 miRNAWalker2_validate -0.196649310139932 4.46744855229911e-10 NA NA NA hsa-miR-28-5p CDC42EP3 0.230152919654905 0.0742909586754846 -1.35474123311743 4.46611463922157e-07 miRanda -0.28719070663781 0.00640642558925848 NA NA NA hsa-miR-28-5p CDC73 0.230152919654905 0.0742909586754846 -0.428384894562094 0.00223307522406707 miRanda -0.214020598811231 7.47465944845484e-05 NA NA NA hsa-miR-28-5p CDCA7L 0.230152919654905 0.0742909586754846 -0.904482813253775 0.0627802908203865 miRanda -0.378513781684004 0.0450811841581361 NA NA NA hsa-miR-484 CDCA7L 1.81844463411787 1.82951571230938e-15 -0.904482813253775 0.0627802908203865 miRNAWalker2_validate -0.301270779968615 0.00257362360366176 NA NA NA hsa-miR-155-5p CDH6 1.20164021433135 0.00086170622431261 -0.982062552967181 0.000735367457247465 miRNAWalker2_validate -0.14983541211419 0.000115438008146056 NA NA NA hsa-miR-28-5p CDK14 0.230152919654905 0.0742909586754846 -0.626728056604694 0.0951702264506212 miRanda -0.45144006860904 0.00189891717375289 NA NA NA hsa-miR-28-5p CDK17 0.230152919654905 0.0742909586754846 -0.521730808799873 0.000274477548938811 miRanda -0.200327978526433 0.00030907590848486 NA NA NA hsa-miR-21-5p CDK19 2.73773305747971 1.38864982139576e-43 -0.0781972308305914 0.561316574571832 miRNAWalker2_validate -0.14822231972902 4.52922930790036e-07 NA NA NA hsa-miR-28-5p CDK5R1 0.230152919654905 0.0742909586754846 1.03270897867958 0.000753590181806008 miRanda -0.419427088722926 0.000424088205918616 NA NA NA hsa-miR-20b-5p CDKN1A 2.07706563022469 1.10107236083433e-05 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase -0.112000786094038 7.41332851839187e-05 NA NA NA hsa-miR-28-5p CDKN1A 0.230152919654905 0.0742909586754846 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;miRanda -0.556544696034112 2.23374029772338e-07 NA NA NA hsa-miR-503-5p CDKN1A 3.66513190181895 6.60300917645278e-21 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase -0.108479527294966 0.00188268400827089 NA NA NA hsa-miR-221-3p CDKN1C 0.451556679024397 0.0909808299917811 -1.44787932669971 3.93876960323515e-05 miRNAWalker2_validate;miRTarBase -0.248677574564568 0.000109625580592135 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-222-3p CDKN1C 0.851783756239071 0.00266783568486918 -1.44787932669971 3.93876960323515e-05 miRNAWalker2_validate;miRTarBase -0.245957660234723 4.42600884082533e-05 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-25-3p CDKN1C 1.36472605225697 4.83790725935681e-11 -1.44787932669971 3.93876960323515e-05 miRNAWalker2_validate;miRTarBase -0.164310296045477 0.0444913812224325 NA NA NA hsa-miR-335-5p CDKN1C 1.77247705492746 2.22457658872091e-06 -1.44787932669971 3.93876960323515e-05 miRNAWalker2_validate -0.104413309854971 0.0214598308380321 NA NA NA hsa-miR-590-3p CDKN1C 2.59289455139753 1.03200520972022e-21 -1.44787932669971 3.93876960323515e-05 miRanda -0.295748909086173 1.56568596656934e-06 NA NA NA hsa-miR-28-5p CDKN2B 0.230152919654905 0.0742909586754846 -0.112970149969128 0.832353274540521 miRanda -0.668331542152576 0.00118921247732729 NA NA NA hsa-miR-28-5p CDON 0.230152919654905 0.0742909586754846 -2.61239140080419 3.20760880328893e-10 miRanda -0.382058064543418 0.020375404594646 NA NA NA hsa-miR-28-5p CDSN 0.230152919654905 0.0742909586754846 1.1576745942266 0.0680115708682292 miRanda -1.23449879066446 3.93537800846365e-07 NA NA NA hsa-miR-28-5p CDX1 0.230152919654905 0.0742909586754846 1.16653302854793 0.0235698254703328 miRanda -0.427394861049905 0.0329119189798873 NA NA NA hsa-miR-375 CELF2 1.13910305294079 0.0512283522214186 -3.04719737979328 4.72041352009215e-15 miRNAWalker2_validate -0.174836909264709 9.98088491313852e-08 NA NA NA hsa-miR-425-5p CELF2 3.07071373939774 4.02947460586085e-25 -3.04719737979328 4.72041352009215e-15 miRNAWalker2_validate -0.654817586042031 9.29447511325308e-30 NA NA NA hsa-miR-21-5p CEP97 2.73773305747971 1.38864982139576e-43 0.059452653600256 0.786139038640759 miRNAWalker2_validate -0.111936597508305 0.0210891018376854 NA NA NA hsa-miR-197-3p CES1 1.75733174019505 8.88576793100499e-13 -4.90117566673161 1.89456282460759e-09 miRNAWalker2_validate -1.21275210170503 5.44777036614969e-15 NA NA NA hsa-miR-320a CES1 0.438165828017084 0.0390159073347133 -4.90117566673161 1.89456282460759e-09 miRanda -0.753130597386317 7.60922744764187e-05 NA NA NA hsa-miR-320b CES1 1.55692969039548 1.41071034251915e-08 -4.90117566673161 1.89456282460759e-09 miRanda -0.96045200820811 1.14087166250139e-11 NA NA NA hsa-miR-155-5p CHD9 1.20164021433135 0.00086170622431261 -0.801892369807601 9.04166624968584e-06 miRNAWalker2_validate -0.114277799750567 2.12595688210708e-06 NA NA NA hsa-miR-28-5p CHL1 0.230152919654905 0.0742909586754846 -2.42464081478466 0.000427906865227034 miRanda -0.962173044096748 0.000322798354415553 NA NA NA hsa-miR-15b-5p CHPF 1.57112623124278 9.14247846750597e-13 0.872541779510142 5.47809317278361e-05 miRNAWalker2_validate -0.254711411733629 3.77205216528247e-08 NA NA NA hsa-miR-421 CHRDL1 1.17791565395543 6.78526676976629e-06 -6.14628787036669 1.26356425887682e-13 miRanda -0.558627341517723 0.000377415525439686 NA NA NA hsa-miR-429 CHRDL1 4.48815175680773 2.44117492218206e-17 -6.14628787036669 1.26356425887682e-13 miRanda -0.695529859221625 1.48672708672465e-22 NA NA NA hsa-miR-590-3p CHRDL1 2.59289455139753 1.03200520972022e-21 -6.14628787036669 1.26356425887682e-13 miRanda -0.964829957282419 4.67935107943776e-11 NA NA NA hsa-miR-28-5p CHSY3 0.230152919654905 0.0742909586754846 -0.520842936542628 0.145406343015898 miRanda -0.495303548875062 0.000336198549706171 NA NA NA hsa-miR-484 CHSY3 1.81844463411787 1.82951571230938e-15 -0.520842936542628 0.145406343015898 miRNAWalker2_validate -0.347989803980219 1.79650882178397e-06 NA NA NA hsa-miR-148b-3p CIDEA 1.97815018171325 6.07715327281595e-26 -2.9680223336343 9.69961862956603e-06 miRNAWalker2_validate -0.375713226834034 0.0237842529435876 NA NA NA hsa-miR-324-5p CIDEA 2.95683728155095 1.32960514360912e-20 -2.9680223336343 9.69961862956603e-06 miRanda -0.19637242638077 0.0466197154535052 NA NA NA hsa-miR-455-5p CIDEA 2.2582442061694 1.43472128037398e-13 -2.9680223336343 9.69961862956603e-06 miRanda -0.215182345868316 0.039651297302828 NA NA NA hsa-miR-28-5p CIDEC 0.230152919654905 0.0742909586754846 -3.43853679771044 4.77830974327662e-08 miRanda -0.595879452285929 0.0164216487562912 NA NA NA hsa-miR-491-5p CIDEC 0.615770352820862 0.0418295628761654 -3.43853679771044 4.77830974327662e-08 miRanda -0.278142448185925 0.0114789977897628 NA NA NA hsa-miR-28-5p CKAP2 0.230152919654905 0.0742909586754846 1.43852526162249 6.73602767422361e-13 miRanda -0.176372194982396 0.0271770392661035 NA NA NA hsa-miR-28-5p CKAP5 0.230152919654905 0.0742909586754846 0.469620409267754 0.00244089758745052 miRanda -0.238348468266894 6.72314368681389e-05 NA NA NA hsa-miR-128-3p CLDN5 1.63756041666078 6.79626586407187e-14 -2.72846432996316 5.15122136682609e-13 miRNAWalker2_validate -0.563406338618634 7.08127393377005e-12 NA NA NA hsa-miR-330-5p CLDN5 1.15100069700871 4.85551805046014e-07 -2.72846432996316 5.15122136682609e-13 miRanda -0.40102897924966 7.2318659712177e-07 NA NA NA hsa-miR-375 CLEC17A 1.13910305294079 0.0512283522214186 -1.80083860842208 0.00046769317306027 miRanda -0.11437561139574 0.00746128893279314 NA NA NA hsa-miR-28-5p CLEC2B 0.230152919654905 0.0742909586754846 -0.835189349629304 0.0495809032042956 miRanda -0.348154885437794 0.0351458245305959 NA NA NA hsa-miR-375 CLEC2B 1.13910305294079 0.0512283522214186 -0.835189349629304 0.0495809032042956 miRanda -0.133490200318836 0.00013628926778198 NA NA NA hsa-miR-335-5p CLEC3B 1.77247705492746 2.22457658872091e-06 -4.95685909341506 1.02256297686959e-33 miRNAWalker2_validate -0.169247204459386 0.00285945944054492 NA NA NA hsa-miR-375 CLEC5A 1.13910305294079 0.0512283522214186 2.07254334943587 6.0252743848656e-06 miRanda -0.111947659722225 0.00336967124182032 NA NA NA hsa-miR-21-5p CLOCK 2.73773305747971 1.38864982139576e-43 -0.505287121256611 0.0368861017220651 miRNAWalker2_validate -0.140077216898868 0.00913637288636243 NA NA NA hsa-miR-425-5p CLU 3.07071373939774 4.02947460586085e-25 -2.85013309153494 5.78926628989519e-08 miRNAWalker2_validate -0.682577615629342 5.76346083558716e-18 NA NA NA hsa-miR-484 CMPK1 1.81844463411787 1.82951571230938e-15 -0.343438944843258 0.00264963726114738 miRNAWalker2_validate -0.115494431149017 6.43427818088416e-07 NA NA NA hsa-miR-28-5p CNIH4 0.230152919654905 0.0742909586754846 0.541679085641475 2.8648002338742e-06 miRanda -0.113859627930657 0.0116219062515377 NA NA NA hsa-miR-326 CNN1 0.715313016136042 0.0610265683213359 -5.78571762204444 4.67275579327069e-17 miRanda -0.259941108853125 0.00438497224639373 NA NA NA hsa-miR-330-5p CNN1 1.15100069700871 4.85551805046014e-07 -5.78571762204444 4.67275579327069e-17 miRanda -1.25778492494709 3.9801315430833e-18 NA NA NA hsa-miR-15a-5p CNN3 2.34669284378787 1.69544424500258e-23 -0.662842637540786 0.00534632089235666 miRNAWalker2_validate -0.294289995644034 1.30664857679721e-10 NA NA NA hsa-miR-375 CNRIP1 1.13910305294079 0.0512283522214186 -2.41101853753387 2.02758497889803e-14 miRanda -0.137654943774349 2.20809989976805e-07 NA NA NA hsa-miR-21-5p COBLL1 2.73773305747971 1.38864982139576e-43 -0.744951480517768 0.016738940742383 miRNAWalker2_validate -0.212488852105423 0.00210321930223624 NA NA NA hsa-miR-375 COL12A1 1.13910305294079 0.0512283522214186 0.611588153376471 0.134337648747937 miRNAWalker2_validate -0.137117632615828 4.32321254535545e-05 NA NA NA hsa-miR-28-5p COL17A1 0.230152919654905 0.0742909586754846 0.854878410767616 0.294122237419345 miRanda -0.879901860655147 0.00529971355515526 NA NA NA hsa-miR-375 COL8A1 1.13910305294079 0.0512283522214186 -0.750287440568718 0.115004485468589 miRanda -0.136025264317486 0.000519325545281371 NA NA NA hsa-miR-28-5p COMMD9 0.230152919654905 0.0742909586754846 0.678489235741425 3.68890248872702e-07 miRanda -0.16155126003873 0.00194262432340033 NA NA NA hsa-miR-17-5p CPE 3.2710598467455 9.93128340539455e-27 -1.65912971992825 4.98796261560473e-06 miRNAWalker2_validate -0.311232118840803 7.24129886297788e-09 NA NA NA hsa-miR-320a CPE 0.438165828017084 0.0390159073347133 -1.65912971992825 4.98796261560473e-06 miRanda -0.240854355453979 0.00430306070417838 NA NA NA hsa-miR-320b CPE 1.55692969039548 1.41071034251915e-08 -1.65912971992825 4.98796261560473e-06 miRanda -0.221749328633865 0.000498031410249492 NA NA NA hsa-miR-335-5p CPE 1.77247705492746 2.22457658872091e-06 -1.65912971992825 4.98796261560473e-06 miRNAWalker2_validate -0.216849319828637 3.11825890135494e-06 NA NA NA hsa-miR-429 CPE 4.48815175680773 2.44117492218206e-17 -1.65912971992825 4.98796261560473e-06 miRanda -0.223688408603845 9.70081444470578e-13 NA NA NA hsa-miR-542-3p CPE 1.18832665895751 1.98700670691565e-07 -1.65912971992825 4.98796261560473e-06 miRanda -0.169812441075952 0.0281036731780248 NA NA NA hsa-miR-590-3p CPE 2.59289455139753 1.03200520972022e-21 -1.65912971992825 4.98796261560473e-06 miRanda -0.238270601993808 0.000198725413366587 NA NA NA hsa-miR-375 CPEB1 1.13910305294079 0.0512283522214186 -4.6814370281438 4.97746958394883e-18 miRanda -0.130183425535446 0.00518787293303063 NA NA NA hsa-miR-21-5p CPEB3 2.73773305747971 1.38864982139576e-43 -1.29730351097465 1.42439515101264e-11 miRNAWalker2_validate -0.297950224728691 2.54702806215992e-12 NA NA NA hsa-miR-28-5p CPSF2 0.230152919654905 0.0742909586754846 0.201328363451912 0.0855603325399402 miRanda -0.246466838682854 3.06236399856369e-08 NA NA NA hsa-miR-183-5p CR1 4.19757025992371 4.79612296318304e-26 -1.98900689989723 0.00029258945582881 miRNAWalker2_validate -0.655021701443984 1.42072412962495e-28 NA NA NA hsa-miR-92b-3p CRIM1 1.20409245530001 3.41055816361655e-06 -0.446663724501645 0.0534037663554592 miRNAWalker2_validate -0.147172222481551 0.000574993440760905 NA NA NA hsa-miR-484 CRTAP 1.81844463411787 1.82951571230938e-15 -1.14140208892668 1.41535459902378e-13 miRNAWalker2_validate -0.30050782230994 3.49259763708534e-22 NA NA NA hsa-miR-140-5p CRYAB 0.844753502512594 3.73722278438606e-05 -3.79700876239956 1.21656735068174e-15 miRanda -0.339303739029014 0.00351514812883945 NA NA NA hsa-miR-324-5p CRYAB 2.95683728155095 1.32960514360912e-20 -3.79700876239956 1.21656735068174e-15 miRanda -0.75153638513694 1.87138611017324e-29 NA NA NA hsa-miR-491-5p CRYAB 0.615770352820862 0.0418295628761654 -3.79700876239956 1.21656735068174e-15 miRanda -0.490132732789992 3.73805681228339e-09 NA NA NA hsa-miR-590-3p CRYAB 2.59289455139753 1.03200520972022e-21 -3.79700876239956 1.21656735068174e-15 miRanda -0.794837899028352 2.68031880877771e-22 NA NA NA hsa-miR-28-5p CSF3 0.230152919654905 0.0742909586754846 -4.55276205983688 3.03447416692714e-08 miRanda -0.636623692387695 0.0498690704905897 NA NA NA hsa-miR-375 CTGF 1.13910305294079 0.0512283522214186 -3.1646965721889 1.41660027051818e-12 miRNAWalker2_validate;miRanda -0.190568830223966 3.79777279474255e-07 NA NA NA hsa-miR-28-5p CTNNB1 0.230152919654905 0.0742909586754846 -0.220922161177096 0.11826020711692 miRanda -0.182072912507331 0.000829385072717343 NA NA NA hsa-miR-28-5p CTNNBIP1 0.230152919654905 0.0742909586754846 0.637035432123162 7.1682291980654e-06 miRanda -0.119345193617078 0.0313778852688492 NA NA NA hsa-miR-590-3p CX3CL1 2.59289455139753 1.03200520972022e-21 -2.32909626913625 3.01541549547016e-08 miRanda -0.426612231554226 6.96677646224435e-09 NA NA NA hsa-miR-375 CX3CR1 1.13910305294079 0.0512283522214186 -1.45623045232348 8.47086101200213e-05 miRanda -0.104160984815912 0.000702477452703448 NA NA NA hsa-miR-126-3p CXCL12 1.6384689127743 1.4473425456641e-10 -3.25514460573678 2.71023256513876e-11 miRNAWalker2_validate -0.270451938229554 0.00367088399794659 NA NA NA hsa-miR-23a-3p CXCL12 1.00493340843378 2.55313889288924e-08 -3.25514460573678 2.71023256513876e-11 miRNAWalker2_validate;miRTarBase -0.665913217473937 5.04733396178919e-07 25322765 MiR-23a suppressed the transcription of RUNX2 and CXCL12 by binding to the 3' UTRs of these mRNAs; The cellular function of miR-23a is RUNX2/CXCL12-dependent and the overexpression of RUNX2 or CXCL12 rescued the impaired cell growth migration and invasion induced by miR-23a sarcoma hsa-miR-31-5p CXCL12 3.59165123035072 2.27423212057482e-07 -3.25514460573678 2.71023256513876e-11 miRNAWalker2_validate -0.245986962195924 4.96339078564571e-12 NA NA NA hsa-miR-320a CXCL12 0.438165828017084 0.0390159073347133 -3.25514460573678 2.71023256513876e-11 miRanda -0.91239452561972 2.1887628621058e-16 NA NA NA hsa-miR-320b CXCL12 1.55692969039548 1.41071034251915e-08 -3.25514460573678 2.71023256513876e-11 miRanda -0.883291306712167 3.2426875813925e-27 NA NA NA hsa-miR-375 CXCL12 1.13910305294079 0.0512283522214186 -3.25514460573678 2.71023256513876e-11 miRanda -0.168576191123304 4.13014098549281e-05 NA NA NA hsa-miR-429 CXCL12 4.48815175680773 2.44117492218206e-17 -3.25514460573678 2.71023256513876e-11 miRanda -0.4784910637442 5.81975116042708e-32 NA NA NA hsa-miR-455-5p CXCL12 2.2582442061694 1.43472128037398e-13 -3.25514460573678 2.71023256513876e-11 miRanda -0.286668694928783 0.000190621446275961 NA NA NA hsa-miR-590-3p CXCL12 2.59289455139753 1.03200520972022e-21 -3.25514460573678 2.71023256513876e-11 miRanda -0.607139014614312 1.21612536925607e-12 NA NA NA hsa-miR-335-5p CXCL2 1.77247705492746 2.22457658872091e-06 -2.98957338490427 3.44123489836297e-07 miRNAWalker2_validate -0.30910994035565 4.26380211623212e-05 NA NA NA hsa-miR-98-5p CXCL2 1.11154309866014 1.24143909012085e-08 -2.98957338490427 3.44123489836297e-07 miRNAWalker2_validate -0.959423198936004 2.16338517471183e-11 NA NA NA hsa-miR-28-5p CXCL5 0.230152919654905 0.0742909586754846 2.41066333970102 0.00233741147115639 miRanda -1.03084173629101 0.000804134344216978 NA NA NA hsa-miR-28-5p CXCL9 0.230152919654905 0.0742909586754846 1.49927890864915 0.0365261889675859 miRanda -0.725233294142816 0.0091803356891712 NA NA NA hsa-miR-484 CYB5R3 1.81844463411787 1.82951571230938e-15 -0.731950831085298 1.12886777708401e-08 miRNAWalker2_validate -0.170922774896403 6.37646407286197e-11 NA NA NA hsa-miR-375 CYBB 1.13910305294079 0.0512283522214186 -0.863943628490373 0.0631881941766158 miRanda -0.129570602608126 0.000721769498552713 NA NA NA hsa-miR-26b-5p CYBRD1 0.885393662798425 3.2116297961629e-06 -2.5547851640342 5.83608437436085e-12 miRNAWalker2_validate -0.616011029180906 9.30452568632118e-11 NA NA NA hsa-miR-301a-3p CYBRD1 2.81024345929638 2.29784847962242e-17 -2.5547851640342 5.83608437436085e-12 miRNAWalker2_validate -0.495956783876858 4.7541238660732e-20 NA NA NA hsa-miR-320a CYBRD1 0.438165828017084 0.0390159073347133 -2.5547851640342 5.83608437436085e-12 miRanda -0.498107528440282 7.56474184484047e-09 NA NA NA hsa-miR-320b CYBRD1 1.55692969039548 1.41071034251915e-08 -2.5547851640342 5.83608437436085e-12 miRanda -0.45363765901787 2.2429361575253e-12 NA NA NA hsa-miR-324-5p CYBRD1 2.95683728155095 1.32960514360912e-20 -2.5547851640342 5.83608437436085e-12 miRanda -0.490117992256778 1.87681500492814e-20 NA NA NA hsa-miR-339-5p CYBRD1 2.68710938429893 3.03134080808154e-16 -2.5547851640342 5.83608437436085e-12 miRanda -0.298148413406946 2.25063406064002e-08 NA NA NA hsa-miR-429 CYBRD1 4.48815175680773 2.44117492218206e-17 -2.5547851640342 5.83608437436085e-12 miRanda -0.399512241543404 1.31378345528572e-39 NA NA NA hsa-miR-590-3p CYBRD1 2.59289455139753 1.03200520972022e-21 -2.5547851640342 5.83608437436085e-12 miRanda -0.516542976992675 1.16146541046247e-15 NA NA NA hsa-miR-92a-3p CYBRD1 2.06460102658973 1.44784291084757e-19 -2.5547851640342 5.83608437436085e-12 miRNAWalker2_validate -0.745928463795799 3.30552198339489e-24 NA NA NA hsa-miR-28-5p CYLD 0.230152919654905 0.0742909586754846 -0.892927493541401 1.56901081849426e-07 miRanda -0.216463273347736 0.00116728924706937 NA NA NA hsa-miR-28-5p CYP27C1 0.230152919654905 0.0742909586754846 -0.531808877337027 0.397962703636672 miRanda -0.845127567961681 0.000504393559794271 NA NA NA hsa-miR-21-5p CYP4V2 2.73773305747971 1.38864982139576e-43 -0.768393525282312 0.000565682222407382 miRNAWalker2_validate -0.118009609502721 0.0175903577085664 NA NA NA hsa-miR-375 CYS1 1.13910305294079 0.0512283522214186 -2.50938489903479 1.46292739809665e-07 miRanda -0.206218319561924 1.82059006808162e-07 NA NA NA hsa-miR-21-5p DAAM1 2.73773305747971 1.38864982139576e-43 -0.942213696830475 0.00027775597362759 miRNAWalker2_validate -0.299047327222438 1.66181520629082e-07 NA NA NA hsa-miR-21-5p DCAF8 2.73773305747971 1.38864982139576e-43 -0.281403004035639 0.0327410367275927 miRNAWalker2_validate -0.127279391996686 1.08569730671782e-05 NA NA NA hsa-miR-125a-5p DCLK1 0.599529391575274 0.0102300147180307 -3.63128048984515 7.09770119804951e-11 miRanda -0.67607139463059 7.38311235997542e-09 NA NA NA hsa-miR-320a DCLK1 0.438165828017084 0.0390159073347133 -3.63128048984515 7.09770119804951e-11 miRanda -0.854234068804798 2.72397659025024e-11 NA NA NA hsa-miR-320b DCLK1 1.55692969039548 1.41071034251915e-08 -3.63128048984515 7.09770119804951e-11 miRanda -0.711770420985352 1.6161460841546e-13 NA NA NA hsa-miR-429 DCLK1 4.48815175680773 2.44117492218206e-17 -3.63128048984515 7.09770119804951e-11 miRanda -0.50211944749027 1.06328513464565e-26 NA NA NA hsa-miR-590-3p DCLK1 2.59289455139753 1.03200520972022e-21 -3.63128048984515 7.09770119804951e-11 miRanda -0.551053362911973 2.16345805573641e-08 NA NA NA hsa-miR-320a DCN 0.438165828017084 0.0390159073347133 -3.45334496072418 3.0714283501425e-12 miRanda -0.885017857237456 5.63097559308097e-15 NA NA NA hsa-miR-320b DCN 1.55692969039548 1.41071034251915e-08 -3.45334496072418 3.0714283501425e-12 miRanda -0.868290115344502 2.31348822218025e-25 NA NA NA hsa-miR-421 DCN 1.17791565395543 6.78526676976629e-06 -3.45334496072418 3.0714283501425e-12 miRanda -0.712973490983918 4.07124694193684e-15 NA NA NA hsa-miR-491-5p DCN 0.615770352820862 0.0418295628761654 -3.45334496072418 3.0714283501425e-12 miRanda -0.484525900445249 1.866547904204e-08 NA NA NA hsa-miR-590-3p DCN 2.59289455139753 1.03200520972022e-21 -3.45334496072418 3.0714283501425e-12 miRanda -0.809280815704104 1.40193401668637e-21 NA NA NA hsa-miR-21-5p DCP1A 2.73773305747971 1.38864982139576e-43 -0.582176734402768 5.81859359116558e-06 miRNAWalker2_validate -0.173169057002769 7.65633792077828e-10 NA NA NA hsa-miR-28-5p DCUN1D3 0.230152919654905 0.0742909586754846 -1.23100715680984 3.16904736813978e-15 miRanda -0.202819430847078 0.00114254527258216 NA NA NA hsa-miR-21-5p DDAH1 2.73773305747971 1.38864982139576e-43 -0.793072804219468 0.015861319078032 miRNAWalker2_validate -0.405404705777747 1.81344613702215e-08 26741162 In vitro study showed QTsome/AM-21 induced upregulation of miR-21 targets including PTEN and DDAH1 in A549 cells while increasing their sensitivity toward paclitaxel PTX lung cancer hsa-miR-21-5p DDHD2 2.73773305747971 1.38864982139576e-43 -0.56807721108283 0.00195245643616029 miRNAWalker2_validate -0.194535074858494 1.46364428156357e-06 NA NA NA hsa-miR-21-5p DDR2 2.73773305747971 1.38864982139576e-43 -3.19296935408292 1.03810493961679e-10 miRNAWalker2_validate -0.331403169912738 0.00311398626573537 NA NA NA hsa-miR-155-5p DDX17 1.20164021433135 0.00086170622431261 -0.394411686924414 0.000497793083577654 miRNAWalker2_validate -0.116047189985277 2.19385922466604e-15 NA NA NA hsa-miR-28-5p DDX21 0.230152919654905 0.0742909586754846 -0.174859915697837 0.500915985498721 miRanda -0.344815621981848 0.000580276213006229 NA NA NA hsa-miR-28-5p DDX31 0.230152919654905 0.0742909586754846 0.53424215036665 4.9283419245491e-05 miRanda -0.176407725809206 0.000550015851339336 NA NA NA hsa-miR-21-5p DDX3X 2.73773305747971 1.38864982139576e-43 -0.807970372827917 1.76139492883823e-10 miRNAWalker2_validate -0.147373833614877 1.83059116490297e-07 NA NA NA hsa-miR-28-5p DDX60 0.230152919654905 0.0742909586754846 0.321134592970657 0.374379059168504 miRanda -0.648428445540536 2.96313874159529e-06 NA NA NA hsa-miR-28-5p DERA 0.230152919654905 0.0742909586754846 0.477867894401827 0.0034637393849653 miRanda -0.325369445823524 2.08521356396146e-07 NA NA NA hsa-miR-155-5p DET1 1.20164021433135 0.00086170622431261 -0.662872225694271 9.55812718377868e-05 miRNAWalker2_validate;miRTarBase -0.137392645728583 8.61934385564102e-10 NA NA NA hsa-miR-28-5p DFNA5 0.230152919654905 0.0742909586754846 -0.786573269718204 0.0666438374568839 miRanda -0.61419956131276 0.000209446210680323 NA NA NA hsa-miR-375 DFNA5 1.13910305294079 0.0512283522214186 -0.786573269718204 0.0666438374568839 miRanda -0.164506267321861 2.8106524186151e-06 NA NA NA hsa-miR-28-5p DGCR5 0.230152919654905 0.0742909586754846 1.62822092460692 0.00442528521800647 miRanda -0.455770201100914 0.00945552395402333 NA NA NA hsa-miR-155-5p DHX40 1.20164021433135 0.00086170622431261 0.153703848564202 0.278434516038548 miRNAWalker2_validate;miRTarBase -0.119098438689501 1.14774191405892e-10 NA NA NA hsa-miR-28-5p DKK3 0.230152919654905 0.0742909586754846 -1.21060856555072 6.73503040405574e-05 miRanda -0.322758009808008 0.00649868961140084 NA NA NA hsa-miR-28-5p DLEU1 0.230152919654905 0.0742909586754846 0.306680324564813 0.195907758326848 miRanda -0.205113048116639 0.0255968342459325 NA NA NA hsa-miR-15a-5p DLK1 2.34669284378787 1.69544424500258e-23 -2.46072183635954 2.980992765441e-05 miRNAWalker2_validate -0.668013872124182 5.76782073615287e-09 NA NA NA hsa-miR-28-5p DLL3 0.230152919654905 0.0742909586754846 2.27110671866481 0.000383357729518536 miRanda -0.536238978225581 0.0318226990725693 NA NA NA hsa-miR-28-5p DLST 0.230152919654905 0.0742909586754846 -0.355993806918142 0.00234441915399013 miRanda -0.263166435582373 3.40490379237282e-09 NA NA NA hsa-miR-28-5p DLX1 0.230152919654905 0.0742909586754846 0.765293374739489 0.163962981361265 miRanda -0.73643135491684 0.000528434395503658 NA NA NA hsa-let-7b-5p DMD 0.604314269683977 0.00140009936153214 -3.69368719337714 3.87883942927561e-15 miRNAWalker2_validate -0.933271195356543 1.77938209695242e-14 NA NA NA hsa-miR-107 DMD 1.30977326593435 1.30372468603965e-11 -3.69368719337714 3.87883942927561e-15 miRanda -0.848654319079876 3.76083423596357e-13 NA NA NA hsa-miR-16-5p DMD 1.75824877145857 1.68592440033108e-16 -3.69368719337714 3.87883942927561e-15 miRNAWalker2_validate -1.02756437649602 3.86110726482189e-24 NA NA NA hsa-miR-21-5p DMD 2.73773305747971 1.38864982139576e-43 -3.69368719337714 3.87883942927561e-15 miRNAWalker2_validate -0.751988520084824 8.85947551431259e-13 NA NA NA hsa-miR-31-5p DMD 3.59165123035072 2.27423212057482e-07 -3.69368719337714 3.87883942927561e-15 miRNAWalker2_validate;miRTarBase -0.208650140559756 2.11928093757756e-09 NA NA NA hsa-miR-320a DMD 0.438165828017084 0.0390159073347133 -3.69368719337714 3.87883942927561e-15 miRanda -0.678953754237415 6.26477029800077e-10 NA NA NA hsa-miR-320b DMD 1.55692969039548 1.41071034251915e-08 -3.69368719337714 3.87883942927561e-15 miRanda -0.656909472014814 9.93629443023417e-16 NA NA NA hsa-miR-324-5p DMD 2.95683728155095 1.32960514360912e-20 -3.69368719337714 3.87883942927561e-15 miRanda -0.65306895857496 2.5505758625819e-22 NA NA NA hsa-miR-330-5p DMD 1.15100069700871 4.85551805046014e-07 -3.69368719337714 3.87883942927561e-15 miRanda -0.474343463840909 2.90917616595061e-06 NA NA NA hsa-miR-361-5p DMD 0.971859117235239 5.30236555707088e-09 -3.69368719337714 3.87883942927561e-15 miRanda -0.98259979855489 9.44387337509879e-13 NA NA NA hsa-miR-362-3p DMD 2.0756816987665 3.89026064579331e-12 -3.69368719337714 3.87883942927561e-15 miRanda -0.326667799721709 3.53980111140835e-05 NA NA NA hsa-miR-375 DMD 1.13910305294079 0.0512283522214186 -3.69368719337714 3.87883942927561e-15 miRanda -0.117284183649694 0.00348000881374864 NA NA NA hsa-miR-429 DMD 4.48815175680773 2.44117492218206e-17 -3.69368719337714 3.87883942927561e-15 miRanda -0.394667080789469 1.90503155752749e-22 NA NA NA hsa-miR-590-3p DMD 2.59289455139753 1.03200520972022e-21 -3.69368719337714 3.87883942927561e-15 miRanda -0.681034238201644 1.14578028210157e-16 NA NA NA hsa-miR-590-5p DMD 3.18300989862077 2.06813568597893e-26 -3.69368719337714 3.87883942927561e-15 miRanda -0.661837270654574 9.26371775907891e-20 NA NA NA hsa-miR-148a-3p DNAJB4 1.26728238710376 2.52325607402829e-06 -1.87183540083745 1.02510662448527e-15 miRNAWalker2_validate -0.177877632102005 3.29117815843735e-05 NA NA NA hsa-miR-28-5p DNM1 0.230152919654905 0.0742909586754846 -0.640115170316246 0.0826514058801314 miRanda -0.435868470256768 0.00227086736149961 NA NA NA hsa-miR-148b-3p DPT 1.97815018171325 6.07715327281595e-26 -5.73773031808694 4.82238994756533e-12 miRNAWalker2_validate -2.3867804033063 1.59162454842932e-35 NA NA NA hsa-miR-361-5p DPT 0.971859117235239 5.30236555707088e-09 -5.73773031808694 4.82238994756533e-12 miRanda -2.31090428047828 8.02239382269183e-23 NA NA NA hsa-miR-421 DPT 1.17791565395543 6.78526676976629e-06 -5.73773031808694 4.82238994756533e-12 miRanda -1.15128666492145 4.57537285600656e-14 NA NA NA hsa-miR-491-5p DPT 0.615770352820862 0.0418295628761654 -5.73773031808694 4.82238994756533e-12 miRanda -0.66481074103814 4.77616172632562e-06 NA NA NA hsa-miR-590-3p DPT 2.59289455139753 1.03200520972022e-21 -5.73773031808694 4.82238994756533e-12 miRanda -1.15843789156957 1.02339708636662e-15 NA NA NA hsa-miR-28-5p DPYD 0.230152919654905 0.0742909586754846 -1.70592656402028 0.000275323430264718 miRanda -1.08763670219928 1.45928180895106e-09 NA NA NA hsa-miR-425-5p DPYSL2 3.07071373939774 4.02947460586085e-25 -1.76435544537318 3.16983700434577e-10 miRNAWalker2_validate -0.447069552802764 3.5561887344632e-27 NA NA NA hsa-miR-375 DPYSL3 1.13910305294079 0.0512283522214186 -2.3174606683978 1.31913973979472e-07 miRNAWalker2_validate -0.114873300302772 0.00177441588646283 NA NA NA hsa-miR-28-5p DSE 0.230152919654905 0.0742909586754846 -0.449387975566177 0.0797883856376828 miRanda -0.437017010096595 9.41315030759658e-06 NA NA NA hsa-miR-28-5p DSG3 0.230152919654905 0.0742909586754846 0.456750837969472 0.702940429314861 miRanda -2.26211506280376 8.35422735757633e-07 NA NA NA hsa-miR-192-5p DST 2.69002528723195 1.22990188194432e-16 -1.11542714896545 9.14769438027749e-05 miRNAWalker2_validate -0.296185440062108 1.48389172051409e-13 NA NA NA hsa-miR-215-5p DST 2.30755467422978 2.38476032118039e-06 -1.11542714896545 9.14769438027749e-05 miRNAWalker2_validate -0.116822025399253 4.8352441908814e-05 NA NA NA hsa-miR-32-5p DST 2.34056473219422 6.24134585974322e-20 -1.11542714896545 9.14769438027749e-05 miRNAWalker2_validate -0.238544808112042 3.7384304559942e-06 NA NA NA hsa-miR-326 DST 0.715313016136042 0.0610265683213359 -1.11542714896545 9.14769438027749e-05 miRanda -0.13208311224818 0.000286310505298768 NA NA NA hsa-miR-335-5p DST 1.77247705492746 2.22457658872091e-06 -1.11542714896545 9.14769438027749e-05 miRNAWalker2_validate -0.100569110968399 0.00607972429463692 NA NA NA hsa-miR-429 DST 4.48815175680773 2.44117492218206e-17 -1.11542714896545 9.14769438027749e-05 miRanda -0.1423154311456 9.09032112657027e-09 NA NA NA hsa-miR-484 DST 1.81844463411787 1.82951571230938e-15 -1.11542714896545 9.14769438027749e-05 miRNAWalker2_validate -0.373614621808623 1.07418311401411e-10 NA NA NA hsa-miR-491-5p DST 0.615770352820862 0.0418295628761654 -1.11542714896545 9.14769438027749e-05 miRanda -0.168181335019031 0.000628981712039069 NA NA NA hsa-miR-590-3p DST 2.59289455139753 1.03200520972022e-21 -1.11542714896545 9.14769438027749e-05 miRanda -0.233583257181658 2.75000894778127e-06 NA NA NA hsa-miR-484 DSTN 1.81844463411787 1.82951571230938e-15 -1.57843644852196 1.87651771072391e-21 miRNAWalker2_validate -0.347882563435258 8.70819357844138e-25 NA NA NA hsa-miR-15a-5p DSTYK 2.34669284378787 1.69544424500258e-23 -0.390903789080284 0.00405232724086959 miRNAWalker2_validate -0.118834205694452 6.86507075621458e-06 NA NA NA hsa-miR-101-3p DUSP1 0.522819989585461 0.00375627731618038 -3.47418646928724 1.98436002754553e-20 miRNAWalker2_validate;miRTarBase -0.239996243623668 0.0247042152262192 NA NA NA hsa-miR-26b-5p DUSP1 0.885393662798425 3.2116297961629e-06 -3.47418646928724 1.98436002754553e-20 miRNAWalker2_validate -0.36876602468636 0.000222882039128576 NA NA NA hsa-miR-429 DUSP1 4.48815175680773 2.44117492218206e-17 -3.47418646928724 1.98436002754553e-20 miRanda -0.326106768941407 1.81178985946822e-23 NA NA NA hsa-miR-28-5p DUSP22 0.230152919654905 0.0742909586754846 -0.785516192242289 7.28024672517459e-07 miRanda -0.217237303139145 0.000447910069379617 NA NA NA hsa-miR-342-3p DUSP6 1.49115144672245 1.43879249744621e-07 -0.400194587052505 0.171488713470446 miRanda -0.204233650547802 3.12630544123288e-05 NA NA NA hsa-miR-21-5p DUSP8 2.73773305747971 1.38864982139576e-43 -2.17002902781112 4.33786956113647e-11 miRNAWalker2_validate -0.321318969065561 1.51976619875534e-05 NA NA NA hsa-miR-21-5p DYNC1LI2 2.73773305747971 1.38864982139576e-43 -0.422943159429528 0.000347029014367825 miRNAWalker2_validate -0.172964608935285 1.55881391694046e-11 NA NA NA hsa-miR-155-5p DYNC2H1 1.20164021433135 0.00086170622431261 -1.38479095589399 7.08863060662035e-06 miRNAWalker2_validate -0.153718671968649 0.000207598937705504 NA NA NA hsa-let-7b-5p DZIP1 0.604314269683977 0.00140009936153214 -1.57008196403815 1.8435672027566e-05 miRNAWalker2_validate -0.289041328885181 0.00241912753733688 NA NA NA hsa-let-7e-5p DZIP1 0.860104282510173 6.04758298373779e-05 -1.57008196403815 1.8435672027566e-05 miRNAWalker2_validate -0.250964105263757 0.00263859274334862 NA NA NA hsa-miR-320a DZIP1 0.438165828017084 0.0390159073347133 -1.57008196403815 1.8435672027566e-05 miRanda -0.304612811072254 0.00032433837193825 NA NA NA hsa-miR-320b DZIP1 1.55692969039548 1.41071034251915e-08 -1.57008196403815 1.8435672027566e-05 miRanda -0.219569581726103 0.000621584636078938 NA NA NA hsa-miR-429 DZIP1 4.48815175680773 2.44117492218206e-17 -1.57008196403815 1.8435672027566e-05 miRanda -0.243493605218063 9.05446012397519e-15 NA NA NA hsa-miR-590-3p DZIP1 2.59289455139753 1.03200520972022e-21 -1.57008196403815 1.8435672027566e-05 miRanda -0.222508530710286 0.000569869952652776 NA NA NA hsa-miR-590-5p DZIP1 3.18300989862077 2.06813568597893e-26 -1.57008196403815 1.8435672027566e-05 miRanda -0.226897785943456 7.98750164857889e-05 NA NA NA hsa-miR-99b-3p DZIP1 1.62436885280973 8.09988670773273e-10 -1.57008196403815 1.8435672027566e-05 miRNAWalker2_validate -0.169521707353744 0.01095758015905 NA NA NA hsa-miR-484 ECE1 1.81844463411787 1.82951571230938e-15 -0.286001205325721 0.0800860129032894 miRNAWalker2_validate -0.197153844096934 2.23059454825563e-09 NA NA NA hsa-miR-484 EDA2R 1.81844463411787 1.82951571230938e-15 -1.49661459960416 0.00020989877769247 miRNAWalker2_validate -0.327354995580073 8.31117698043578e-05 NA NA NA hsa-miR-21-5p EDIL3 2.73773305747971 1.38864982139576e-43 -1.39552344263701 0.00540706010756216 miRNAWalker2_validate -0.234320454757888 0.0361789729874622 NA NA NA hsa-miR-146b-5p EDNRB 1.75587235896724 1.15724631266659e-07 -2.52310122132934 4.0560560911117e-12 miRanda -0.212309861517772 7.36253521489119e-05 NA NA NA hsa-miR-330-5p EDNRB 1.15100069700871 4.85551805046014e-07 -2.52310122132934 4.0560560911117e-12 miRanda -0.17078744558023 0.0299101837964694 NA NA NA hsa-miR-34c-5p EDNRB 2.07190852984647 7.35776320806257e-08 -2.52310122132934 4.0560560911117e-12 miRanda -0.180849122108154 0.000236146137456392 NA NA NA hsa-miR-361-5p EDNRB 0.971859117235239 5.30236555707088e-09 -2.52310122132934 4.0560560911117e-12 miRanda -0.395863788394647 0.000247992936358809 NA NA NA hsa-miR-455-5p EDNRB 2.2582442061694 1.43472128037398e-13 -2.52310122132934 4.0560560911117e-12 miRanda -0.389044179927601 4.35464795106217e-12 NA NA NA hsa-miR-590-3p EDNRB 2.59289455139753 1.03200520972022e-21 -2.52310122132934 4.0560560911117e-12 miRanda -0.412108917399406 1.27730593842419e-10 NA NA NA hsa-miR-590-5p EDNRB 3.18300989862077 2.06813568597893e-26 -2.52310122132934 4.0560560911117e-12 miRanda -0.369052712452384 1.10518759385903e-10 NA NA NA hsa-miR-15b-5p EEF1A1 1.57112623124278 9.14247846750597e-13 -0.872620059093524 3.57505231498267e-09 miRNAWalker2_validate -0.18593352272081 5.32155375642228e-09 NA NA NA hsa-miR-484 EEF1A1 1.81844463411787 1.82951571230938e-15 -0.872620059093524 3.57505231498267e-09 miRNAWalker2_validate -0.122668796915228 6.53296025696881e-05 NA NA NA hsa-miR-155-5p EEF1A2 1.20164021433135 0.00086170622431261 1.68325882965437 0.0520105787635011 miRNAWalker2_validate -0.720121140119452 2.32978373815324e-10 NA NA NA hsa-miR-146b-5p EFHC1 1.75587235896724 1.15724631266659e-07 0.282419349632015 0.138329919386545 miRanda -0.183648161527956 6.79625921373974e-12 NA NA NA hsa-miR-128-3p EGFR 1.63756041666078 6.79626586407187e-14 -0.229170429190265 0.593897211976523 miRNAWalker2_validate;miRTarBase -0.202545235408722 0.029374382947331 NA NA NA hsa-miR-140-5p EGFR 0.844753502512594 3.73722278438606e-05 -0.229170429190265 0.593897211976523 miRanda -0.290336016621899 0.00422174515988415 NA NA NA hsa-miR-320a EGFR 0.438165828017084 0.0390159073347133 -0.229170429190265 0.593897211976523 miRanda -0.237441545432742 0.0161714500455112 NA NA NA hsa-miR-335-5p EGFR 1.77247705492746 2.22457658872091e-06 -0.229170429190265 0.593897211976523 miRNAWalker2_validate -0.107777488168613 0.0497360336107625 NA NA NA hsa-miR-342-3p EGFR 1.49115144672245 1.43879249744621e-07 -0.229170429190265 0.593897211976523 miRanda -0.145868494821454 0.0444309022820605 NA NA NA hsa-miR-183-5p EGR1 4.19757025992371 4.79612296318304e-26 -3.49744704460324 2.85713025013704e-20 miRNAWalker2_validate;miRTarBase -0.41320624686701 1.33575605613498e-21 NA NA NA hsa-miR-192-5p EGR1 2.69002528723195 1.22990188194432e-16 -3.49744704460324 2.85713025013704e-20 miRNAWalker2_validate -0.328535306070491 5.03714597607373e-09 NA NA NA hsa-miR-215-5p EGR1 2.30755467422978 2.38476032118039e-06 -3.49744704460324 2.85713025013704e-20 miRNAWalker2_validate -0.163759058357407 3.91164065696044e-05 NA NA NA hsa-miR-429 EGR1 4.48815175680773 2.44117492218206e-17 -3.49744704460324 2.85713025013704e-20 miRanda -0.321338414658228 2.90606691090522e-22 NA NA NA hsa-miR-590-3p EGR1 2.59289455139753 1.03200520972022e-21 -3.49744704460324 2.85713025013704e-20 miRanda -0.426819050925493 4.20081750916032e-10 NA NA NA hsa-miR-28-5p EGR3 0.230152919654905 0.0742909586754846 -4.24788771954966 5.33225463207111e-21 miRanda -0.547739338709063 0.0028950829325781 NA NA NA hsa-miR-28-5p EIF4A1 0.230152919654905 0.0742909586754846 0.129339999899665 0.367575005349502 miRanda -0.24532054169176 8.04097310966373e-06 NA NA NA hsa-miR-21-5p EIF4A2 2.73773305747971 1.38864982139576e-43 -0.427139544199033 0.0025058469457631 miRNAWalker2_validate;miRTarBase -0.167815345781453 5.85534419005924e-08 NA NA NA hsa-miR-484 EIF4B 1.81844463411787 1.82951571230938e-15 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.115522506643854 2.13739109619376e-05 NA NA NA hsa-miR-21-5p EIF4EBP2 2.73773305747971 1.38864982139576e-43 -0.670975600716861 1.12232644895605e-07 miRNAWalker2_validate -0.230842486199861 2.76066981745431e-17 NA NA NA hsa-miR-146b-5p ELF5 1.75587235896724 1.15724631266659e-07 0.598658693294086 0.42287192357736 miRanda -0.67552233537791 1.47775985526497e-10 NA NA NA hsa-miR-217 ELF5 0.608024397387488 0.199352491710517 0.598658693294086 0.42287192357736 miRanda -0.2196458527486 0.00504430756979477 NA NA NA hsa-miR-338-3p ELF5 0.453166438193782 0.144583389707558 0.598658693294086 0.42287192357736 miRanda -0.269770630724996 0.0207687660762254 NA NA NA hsa-miR-34c-5p ELF5 2.07190852984647 7.35776320806257e-08 0.598658693294086 0.42287192357736 miRanda -0.198510890983077 0.0445670669196514 NA NA NA hsa-miR-28-5p ELK3 0.230152919654905 0.0742909586754846 -0.31361161770499 0.256409444995651 miRanda -0.340967303773823 0.00140502101910943 NA NA NA hsa-miR-28-5p ENPEP 0.230152919654905 0.0742909586754846 -0.330088475799641 0.366156594438613 miRanda -0.28459214985993 0.0445605868330637 NA NA NA hsa-miR-375 ENPP1 1.13910305294079 0.0512283522214186 -2.09860918748668 4.30690633215035e-06 miRanda -0.101758981296438 0.00759473144020097 NA NA NA hsa-miR-196a-5p EPHA7 1.52993069622497 0.00397268663639603 -4.20206952913252 6.81894380739864e-12 miRNAWalker2_validate -0.21685543995836 0.000134406342849576 NA NA NA hsa-miR-21-5p EPM2A 2.73773305747971 1.38864982139576e-43 -1.90233116870269 9.7764279872753e-23 miRNAWalker2_validate -0.431740270415939 8.46427965340224e-24 NA NA NA hsa-miR-183-5p ERC1 4.19757025992371 4.79612296318304e-26 -1.0981015647741 3.01720605629387e-09 miRNAWalker2_validate -0.187590772888012 8.26545482339226e-20 NA NA NA hsa-miR-155-5p ERMP1 1.20164021433135 0.00086170622431261 0.589026563231732 0.0468726315405969 miRNAWalker2_validate -0.14436832816196 0.000253254823839409 NA NA NA hsa-miR-28-5p ERP44 0.230152919654905 0.0742909586754846 0.203025156088515 0.0863674386872067 miRanda -0.131461165989169 0.00393920468962376 NA NA NA hsa-miR-20b-5p ESR1 2.07706563022469 1.10107236083433e-05 -2.8683110246507 7.71528352232079e-10 miRNAWalker2_validate;miRTarBase -0.10001813259544 0.0383961541199103 NA NA NA hsa-miR-21-5p ESYT2 2.73773305747971 1.38864982139576e-43 -0.746139987963661 9.56205989329786e-07 miRNAWalker2_validate -0.137833261763619 4.81573567099963e-05 NA NA NA hsa-miR-28-5p ETF1 0.230152919654905 0.0742909586754846 -0.754114058518203 6.31750757964212e-10 miRanda -0.310254529656518 4.11277939790967e-11 NA NA NA hsa-miR-200b-3p ETS1 3.78235093249346 3.18343003239465e-14 -0.699528618233348 0.00228038287696191 miRNAWalker2_validate;miRTarBase -0.126548351947289 2.52221854075541e-09 NA NA NA hsa-miR-21-5p EXOC5 2.73773305747971 1.38864982139576e-43 -0.347825206882579 0.00996981836282781 miRNAWalker2_validate -0.123384866659596 3.28658174527071e-05 NA NA NA hsa-miR-28-5p EXOC5 0.230152919654905 0.0742909586754846 -0.347825206882579 0.00996981836282781 miRanda -0.263053539964104 3.50767590323882e-07 NA NA NA hsa-miR-155-5p EXOC7 1.20164021433135 0.00086170622431261 0.00902629087621332 0.936973251441974 miRNAWalker2_validate -0.139096531429213 4.1240131914845e-22 NA NA NA hsa-miR-28-5p EXOSC2 0.230152919654905 0.0742909586754846 0.456013674648747 0.000700396223115148 miRanda -0.121571195958811 0.0199759671879216 NA NA NA hsa-miR-766-3p EZH1 1.2456012547833 6.44584025471128e-06 -0.753214967431468 9.91463335398166e-08 miRNAWalker2_validate -0.163740947477111 1.7180301145812e-11 NA NA NA hsa-miR-130b-3p F3 3.5350292994509 1.73934183852569e-27 -1.92612930805695 0.000148150348095098 miRNAWalker2_validate -0.378733720928625 7.25847675415319e-08 NA NA NA hsa-miR-320a F3 0.438165828017084 0.0390159073347133 -1.92612930805695 0.000148150348095098 miRanda -0.528872247967981 5.71516794463757e-06 NA NA NA hsa-miR-320b F3 1.55692969039548 1.41071034251915e-08 -1.92612930805695 0.000148150348095098 miRanda -0.315774026924065 0.000366720863697655 NA NA NA hsa-miR-421 F3 1.17791565395543 6.78526676976629e-06 -1.92612930805695 0.000148150348095098 miRanda -0.314885802132622 0.000806375291265993 NA NA NA hsa-miR-93-5p F3 3.03961860136032 1.11672209617395e-24 -1.92612930805695 0.000148150348095098 miRNAWalker2_validate -0.581211758123988 3.21242470154706e-14 NA NA NA hsa-miR-146b-5p FABP4 1.75587235896724 1.15724631266659e-07 -3.84988422814546 1.32320931221268e-05 miRanda -0.507736387576667 7.26443061417227e-05 NA NA NA hsa-miR-590-3p FABP4 2.59289455139753 1.03200520972022e-21 -3.84988422814546 1.32320931221268e-05 miRanda -0.742560955450048 1.61387952113273e-06 NA NA NA hsa-miR-28-5p FABP7 0.230152919654905 0.0742909586754846 0.138969848338937 0.823269225034878 miRanda -0.685971592305155 0.00438242383563866 NA NA NA hsa-miR-107 FAM107A 1.30977326593435 1.30372468603965e-11 -5.00865420988181 1.32570913157414e-25 miRanda -0.837170761276294 9.13813365645167e-12 NA NA NA hsa-miR-342-3p FAM107A 1.49115144672245 1.43879249744621e-07 -5.00865420988181 1.32570913157414e-25 miRanda -0.174604881454117 0.042621551446486 NA NA NA hsa-miR-34c-5p FAM107A 2.07190852984647 7.35776320806257e-08 -5.00865420988181 1.32570913157414e-25 miRanda -0.322165024146345 1.35713039652631e-06 NA NA NA hsa-miR-491-5p FAM107A 0.615770352820862 0.0418295628761654 -5.00865420988181 1.32570913157414e-25 miRanda -0.182484675373291 0.0373792553705055 NA NA NA hsa-miR-590-5p FAM107A 3.18300989862077 2.06813568597893e-26 -5.00865420988181 1.32570913157414e-25 miRanda -0.723233262093252 1.42146702367584e-21 NA NA NA hsa-miR-183-5p FAM110B 4.19757025992371 4.79612296318304e-26 -2.48922603317359 1.34073850217782e-09 miRNAWalker2_validate -0.414375093714896 1.54925163694953e-19 NA NA NA hsa-miR-484 FAM117A 1.81844463411787 1.82951571230938e-15 -1.05842116659401 6.67842596421404e-08 miRNAWalker2_validate -0.140769877377553 0.000554470251569488 NA NA NA hsa-miR-425-5p FAM122A 3.07071373939774 4.02947460586085e-25 -0.694390382440341 4.68201929407605e-08 miRNAWalker2_validate -0.118800075766941 9.98536627799123e-10 NA NA NA hsa-miR-28-5p FAM126A 0.230152919654905 0.0742909586754846 -0.533719136310947 0.100152010348378 miRanda -0.784891971395167 1.98099110608786e-10 NA NA NA hsa-miR-484 FAM129A 1.81844463411787 1.82951571230938e-15 -2.92472325852437 7.78860786211284e-14 miRNAWalker2_validate -0.829625670059546 2.35785180753219e-26 NA NA NA hsa-miR-484 FAM129B 1.81844463411787 1.82951571230938e-15 0.0986544551232456 0.616324265821885 miRNAWalker2_validate -0.125043077517109 0.00192329971606181 NA NA NA hsa-miR-28-5p FAM160A2 0.230152919654905 0.0742909586754846 -0.399167208199967 0.000108858520177447 miRanda -0.128850103103447 0.00123455660521984 NA NA NA hsa-miR-375 FAM180A 1.13910305294079 0.0512283522214186 -4.00516921160209 1.49792389223468e-12 miRanda -0.188712750525675 7.96585675017772e-05 NA NA NA hsa-miR-21-5p FAM20B 2.73773305747971 1.38864982139576e-43 -0.242747585765756 0.0401331756487193 miRNAWalker2_validate -0.109622582453276 2.39603891259926e-05 NA NA NA hsa-miR-21-5p FAM46A 2.73773305747971 1.38864982139576e-43 -1.53838927503324 2.52497889501001e-11 miRNAWalker2_validate -0.247101366458922 1.92273836815591e-06 NA NA NA hsa-miR-484 FAM46A 1.81844463411787 1.82951571230938e-15 -1.53838927503324 2.52497889501001e-11 miRNAWalker2_validate -0.182798970849807 0.000156356049300188 NA NA NA hsa-miR-15a-5p FAM69A 2.34669284378787 1.69544424500258e-23 -0.968484116353738 0.000125443656021231 miRNAWalker2_validate -0.31595421726479 9.37946665724112e-11 NA NA NA hsa-miR-28-5p FAM69A 0.230152919654905 0.0742909586754846 -0.968484116353738 0.000125443656021231 miRanda -0.325612476819225 0.00092205658031841 NA NA NA hsa-miR-375 FAP 1.13910305294079 0.0512283522214186 0.811741651660897 0.168731033359055 miRanda -0.16345695202425 0.000764416555866564 NA NA NA hsa-miR-28-5p FBLN7 0.230152919654905 0.0742909586754846 -0.907445677404678 0.0201482373585628 miRanda -0.397923436189576 0.00868871935856186 NA NA NA hsa-miR-21-5p FBXL17 2.73773305747971 1.38864982139576e-43 -0.806582888627894 8.84264200988688e-08 miRNAWalker2_validate -0.252053908605312 1.68330860864529e-14 NA NA NA hsa-miR-15a-5p FBXO3 2.34669284378787 1.69544424500258e-23 -0.623017822802069 3.02847471908555e-05 miRNAWalker2_validate -0.1146015639341 9.07337132664747e-05 NA NA NA hsa-miR-21-5p FBXO3 2.73773305747971 1.38864982139576e-43 -0.623017822802069 3.02847471908555e-05 miRNAWalker2_validate -0.115540329697111 0.000504714122305686 NA NA NA hsa-miR-15b-5p FBXO30 1.57112623124278 9.14247846750597e-13 -1.16177838316659 6.43503119433016e-13 miRNAWalker2_validate -0.142519181544157 6.11263937727833e-05 NA NA NA hsa-miR-484 FBXW2 1.81844463411787 1.82951571230938e-15 -0.266146776228673 0.035224661304761 miRNAWalker2_validate -0.110638363848243 1.69743155459662e-05 NA NA NA hsa-miR-28-5p FCHO2 0.230152919654905 0.0742909586754846 -0.438286274224125 0.00271373684474576 miRanda -0.15812599381457 0.00524543619358107 NA NA NA hsa-miR-28-5p FCHSD2 0.230152919654905 0.0742909586754846 -0.289220927768126 0.0298701081670641 miRanda -0.122364201111179 0.0174932383081004 NA NA NA hsa-miR-375 FCRL3 1.13910305294079 0.0512283522214186 -1.1104578293059 0.0570243629904007 miRanda -0.116479412342913 0.0157878940227509 NA NA NA hsa-miR-155-5p FDFT1 1.20164021433135 0.00086170622431261 0.278261186049502 0.189324613454178 miRNAWalker2_validate -0.12360441375581 1.05692025728868e-05 NA NA NA hsa-miR-28-5p FEM1C 0.230152919654905 0.0742909586754846 -0.864277861779754 7.12575375361754e-10 miRanda -0.179765889922228 0.00111981359260531 NA NA NA hsa-miR-21-5p FERMT2 2.73773305747971 1.38864982139576e-43 -2.62997740238291 6.83872718492897e-15 miRNAWalker2_validate -0.382799442660283 5.99044819328367e-07 NA NA NA hsa-miR-28-5p FGF1 0.230152919654905 0.0742909586754846 -0.0184880339301951 0.962515192576832 miRanda -0.307527561468243 0.0437651717819831 NA NA NA hsa-miR-503-5p FGF2 3.66513190181895 6.60300917645278e-21 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.407288478531313 2.50922381458507e-15 NA NA NA hsa-miR-15a-5p FGF7 2.34669284378787 1.69544424500258e-23 -3.51313263207438 7.95527572408387e-12 miRTarBase -1.05153766439707 1.95358882887929e-27 NA NA NA hsa-miR-107 FGFR2 1.30977326593435 1.30372468603965e-11 -1.10510536599184 0.0128825317606034 miRanda -0.398153526215925 0.00027439034373613 NA NA NA hsa-miR-146b-5p FGFR2 1.75587235896724 1.15724631266659e-07 -1.10510536599184 0.0128825317606034 miRanda -0.146244445164253 0.022817620173302 NA NA NA hsa-miR-186-5p FGFR2 1.47445398888668 3.0781726595413e-15 -1.10510536599184 0.0128825317606034 miRNAWalker2_validate -0.471854892718397 2.53033898213571e-05 NA NA NA hsa-miR-193a-3p FGFR2 1.60460546928078 2.86169793322984e-07 -1.10510536599184 0.0128825317606034 miRanda -0.184992348766107 0.00659604280779591 NA NA NA hsa-miR-19b-1-5p FGFR2 2.57951428759379 4.31576118703427e-20 -1.10510536599184 0.0128825317606034 miRNAWalker2_validate;miRTarBase -0.4345309219133 4.77765562006864e-09 NA NA NA hsa-miR-324-5p FGFR2 2.95683728155095 1.32960514360912e-20 -1.10510536599184 0.0128825317606034 miRanda -0.24680525694008 0.000127710806173706 NA NA NA hsa-miR-338-3p FGFR2 0.453166438193782 0.144583389707558 -1.10510536599184 0.0128825317606034 miRanda -0.263518769420772 0.000141261313872914 NA NA NA hsa-miR-590-3p FGFR2 2.59289455139753 1.03200520972022e-21 -1.10510536599184 0.0128825317606034 miRanda -0.311141579023723 6.00872154446622e-05 NA NA NA hsa-miR-125a-3p FHL1 1.24490295132072 5.26925231010328e-06 -4.79489740738213 4.58621609455402e-20 miRanda -0.41545589181367 1.45323512026427e-05 NA NA NA hsa-miR-193a-3p FHL1 1.60460546928078 2.86169793322984e-07 -4.79489740738213 4.58621609455402e-20 miRanda -0.186117083197584 0.0266114770837681 NA NA NA hsa-miR-335-5p FHL1 1.77247705492746 2.22457658872091e-06 -4.79489740738213 4.58621609455402e-20 miRNAWalker2_validate -0.409089399152926 2.82959403534918e-09 NA NA NA hsa-miR-339-5p FHL1 2.68710938429893 3.03134080808154e-16 -4.79489740738213 4.58621609455402e-20 miRanda -0.628341836793117 5.43216061383931e-17 NA NA NA hsa-miR-421 FHL1 1.17791565395543 6.78526676976629e-06 -4.79489740738213 4.58621609455402e-20 miRanda -0.512877033491861 2.80718704620397e-07 NA NA NA hsa-miR-429 FHL1 4.48815175680773 2.44117492218206e-17 -4.79489740738213 4.58621609455402e-20 miRanda -0.593285227083957 1.03672281764204e-42 NA NA NA hsa-miR-455-5p FHL1 2.2582442061694 1.43472128037398e-13 -4.79489740738213 4.58621609455402e-20 miRanda -0.478400862288126 8.74352551625747e-09 NA NA NA hsa-miR-590-3p FHL1 2.59289455139753 1.03200520972022e-21 -4.79489740738213 4.58621609455402e-20 miRanda -1.00083671270898 6.20243499334683e-29 NA NA NA hsa-miR-28-5p FHOD1 0.230152919654905 0.0742909586754846 0.606822113176475 0.000711612899453606 miRanda -0.144247806759874 0.0388079695937543 NA NA NA hsa-miR-375 FILIP1 1.13910305294079 0.0512283522214186 -3.98295770948621 7.6403119563799e-20 miRanda -0.162815452744417 1.44074371475028e-05 NA NA NA hsa-miR-21-5p FILIP1L 2.73773305747971 1.38864982139576e-43 -2.82121091474125 4.17329905162324e-15 miRNAWalker2_validate -0.291253453805328 0.000399467133984634 NA NA NA hsa-miR-28-5p FKBP15 0.230152919654905 0.0742909586754846 0.10604363094931 0.348710569387007 miRanda -0.186068926973702 1.6866729496923e-05 NA NA NA hsa-miR-125a-3p FKBP5 1.24490295132072 5.26925231010328e-06 -1.54368679613987 4.05564573895986e-05 miRanda -0.248651955044189 0.000184008839743608 NA NA NA hsa-miR-320a FKBP5 0.438165828017084 0.0390159073347133 -1.54368679613987 4.05564573895986e-05 miRanda -0.59122070061467 3.67853751711178e-12 NA NA NA hsa-miR-320b FKBP5 1.55692969039548 1.41071034251915e-08 -1.54368679613987 4.05564573895986e-05 miRanda -0.370838991311812 1.14696538693856e-08 NA NA NA hsa-miR-328-3p FKBP5 0.596804159297544 0.013858523511843 -1.54368679613987 4.05564573895986e-05 miRNAWalker2_validate -0.301917532270589 6.48067778138293e-05 NA NA NA hsa-miR-590-3p FKBP5 2.59289455139753 1.03200520972022e-21 -1.54368679613987 4.05564573895986e-05 miRanda -0.136694922896888 0.039830152065017 NA NA NA hsa-miR-590-5p FKBP5 3.18300989862077 2.06813568597893e-26 -1.54368679613987 4.05564573895986e-05 miRanda -0.237307104039564 5.67079514865391e-05 NA NA NA hsa-miR-93-3p FKBP5 2.85383869771942 5.64481766902125e-23 -1.54368679613987 4.05564573895986e-05 miRNAWalker2_validate -0.457352321135298 4.67685246660216e-15 NA NA NA hsa-miR-484 FLII 1.81844463411787 1.82951571230938e-15 -0.28534702678142 0.0254765821198304 miRNAWalker2_validate -0.102247335546734 8.68411022571862e-05 NA NA NA hsa-miR-484 FLNA 1.81844463411787 1.82951571230938e-15 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.831848183638064 2.17819747551506e-31 NA NA NA hsa-miR-155-5p FLT1 1.20164021433135 0.00086170622431261 -0.398798139585047 0.102684609418445 miRNAWalker2_validate -0.124036074181 0.000133378861297828 NA NA NA hsa-miR-125a-5p FMO2 0.599529391575274 0.0102300147180307 -2.4057104016729 0.000137336354224179 miRanda -0.793561379216217 1.03398436962463e-09 NA NA NA hsa-miR-129-5p FMO2 -0.524170159980738 0.222582956006346 -2.4057104016729 0.000137336354224179 miRanda -0.265962030426403 0.000255281089388936 NA NA NA hsa-miR-421 FMO2 1.17791565395543 6.78526676976629e-06 -2.4057104016729 0.000137336354224179 miRanda -0.444068769694388 0.000139802548978626 NA NA NA hsa-miR-486-5p FMO2 -0.194913133034028 0.607377798807705 -2.4057104016729 0.000137336354224179 miRanda -0.435502934319228 5.47367191192499e-08 NA NA NA hsa-miR-590-3p FMO2 2.59289455139753 1.03200520972022e-21 -2.4057104016729 0.000137336354224179 miRanda -0.573242488892594 1.85278870982218e-07 NA NA NA hsa-miR-28-5p FMOD 0.230152919654905 0.0742909586754846 -1.52192128466791 0.000151731290314199 miRanda -0.435064798748087 0.00551146073931312 NA NA NA hsa-miR-200b-3p FN1 3.78235093249346 3.18343003239465e-14 -0.407678263046535 0.457934813442308 miRNAWalker2_validate;miRTarBase -0.597950765256644 8.42251389081856e-37 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-21-5p FNBP1 2.73773305747971 1.38864982139576e-43 -1.88855087744431 6.2899280961967e-20 miRNAWalker2_validate -0.359556806569933 1.10419374502365e-14 NA NA NA hsa-miR-181a-5p FOS 2.29556023480783 1.8138457900616e-21 -3.39745351917485 1.25524442357693e-17 miRNAWalker2_validate;miRTarBase -0.406931044177245 2.15032589233814e-07 NA NA NA hsa-miR-192-5p FOS 2.69002528723195 1.22990188194432e-16 -3.39745351917485 1.25524442357693e-17 miRNAWalker2_validate -0.247944413799652 2.71034229894278e-05 NA NA NA hsa-miR-221-3p FOS 0.451556679024397 0.0909808299917811 -3.39745351917485 1.25524442357693e-17 miRNAWalker2_validate;miRTarBase -0.174633248532022 0.0205420980307199 NA NA NA hsa-miR-222-3p FOS 0.851783756239071 0.00266783568486918 -3.39745351917485 1.25524442357693e-17 miRNAWalker2_validate;miRTarBase -0.233914002507589 0.000901382653088722 NA NA NA hsa-miR-29b-3p FOS 1.65828197923813 1.02676780888141e-09 -3.39745351917485 1.25524442357693e-17 miRNAWalker2_validate -0.19998058463295 0.00584509977497633 NA NA NA hsa-miR-335-5p FOS 1.77247705492746 2.22457658872091e-06 -3.39745351917485 1.25524442357693e-17 miRNAWalker2_validate -0.179920825828979 0.000646944858498294 NA NA NA hsa-miR-361-5p FOS 0.971859117235239 5.30236555707088e-09 -3.39745351917485 1.25524442357693e-17 miRanda -0.484687813338039 5.02065687497632e-05 NA NA NA hsa-miR-362-3p FOS 2.0756816987665 3.89026064579331e-12 -3.39745351917485 1.25524442357693e-17 miRanda -0.338731817794186 4.09940306270337e-07 NA NA NA hsa-miR-590-3p FOS 2.59289455139753 1.03200520972022e-21 -3.39745351917485 1.25524442357693e-17 miRanda -0.527553188053258 6.91172092082184e-14 NA NA NA hsa-miR-342-3p FOSB 1.49115144672245 1.43879249744621e-07 -4.56223376749248 1.41483499844653e-17 miRanda -0.385055346786639 3.78778332842603e-05 NA NA NA hsa-miR-375 FOXF1 1.13910305294079 0.0512283522214186 -3.59969497191247 8.05975763421163e-22 miRanda -0.114364503991713 0.000434848263489808 NA NA NA hsa-miR-28-5p FOXJ2 0.230152919654905 0.0742909586754846 -0.61900156905543 0.000173363046232332 miRanda -0.208935033208114 0.00110093711721765 NA NA NA hsa-miR-28-5p FOXL2 0.230152919654905 0.0742909586754846 2.73454700103597 4.81076937832295e-05 miRanda -0.665229548093076 0.0114648896234277 NA NA NA hsa-miR-21-5p FOXN3 2.73773305747971 1.38864982139576e-43 -1.43525991184281 2.70084540955391e-16 miRNAWalker2_validate -0.305419413084872 5.20876824892874e-15 NA NA NA hsa-miR-92b-3p FOXN3 1.20409245530001 3.41055816361655e-06 -1.43525991184281 2.70084540955391e-16 miRNAWalker2_validate -0.132236379684742 7.97102083226711e-05 NA NA NA hsa-miR-15a-5p FOXO1 2.34669284378787 1.69544424500258e-23 -1.06087355985292 3.97103810866528e-08 miRNAWalker2_validate -0.168920630569665 9.34067717132342e-06 NA NA NA hsa-miR-183-5p FOXO1 4.19757025992371 4.79612296318304e-26 -1.06087355985292 3.97103810866528e-08 miRNAWalker2_validate;miRTarBase -0.126985467448341 8.49038349636014e-09 25813403;25983004 Knockdown of CTNNB1 also showed concordant down-regulations of miR-183 -96 and -182 and the re-expression of FOXO1;MiR 183 promotes growth of non small cell lung cancer cells through FoxO1 inhibition; Here we analyzed the regulation of FoxO1 by miR-183 in vitro using luciferase-reporter assay; Moreover miR-183 bound to FoxO1 mRNA to prevent its translation through its 3'untranslated region UTR; Furthermore administration of miR-183 suppressed FoxO1 levels in NSCLC resulting in a significant increase in NSCLC growth in vitro and in vivo while administration of antisense of miR-183 significantly increased FoxO1 levels in NSCLC resulting in a significant decrease in NSCLC growth ; liver cancer;lung squamous cell cancer hsa-miR-375 FPR2 1.13910305294079 0.0512283522214186 -0.451486145134382 0.409190472643312 miRanda -0.10795552630226 0.0168360948523097 NA NA NA hsa-miR-28-5p FRMD4B 0.230152919654905 0.0742909586754846 -0.595669619125329 0.044790621768531 miRanda -0.546881296770699 1.62083154092752e-06 NA NA NA hsa-miR-375 FRMD6 1.13910305294079 0.0512283522214186 -0.932146068496432 0.00182819765018773 miRanda -0.163398398364754 1.55624442629226e-11 NA NA NA hsa-miR-28-5p FUBP3 0.230152919654905 0.0742909586754846 -0.25026664264894 0.0400550507577286 miRanda -0.146996923923527 0.00174621248150633 NA NA NA hsa-miR-28-5p FUT11 0.230152919654905 0.0742909586754846 0.102461844239859 0.584695036846754 miRanda -0.259517495202732 0.000323589156477986 NA NA NA hsa-miR-484 FUT11 1.81844463411787 1.82951571230938e-15 0.102461844239859 0.584695036846754 miRNAWalker2_validate -0.101369617298108 0.00835781458088356 NA NA NA hsa-miR-484 FYCO1 1.81844463411787 1.82951571230938e-15 -1.6226100593392 1.01871130782658e-16 miRNAWalker2_validate -0.363679222305366 8.05656945038937e-20 NA NA NA hsa-miR-125a-5p GABRP 0.599529391575274 0.0102300147180307 0.0195783716200864 0.983288506607067 miRanda -0.912319732740895 2.18216726772442e-06 NA NA NA hsa-miR-320a GABRP 0.438165828017084 0.0390159073347133 0.0195783716200864 0.983288506607067 miRanda -0.98468438807563 3.69591649833275e-06 NA NA NA hsa-miR-320b GABRP 1.55692969039548 1.41071034251915e-08 0.0195783716200864 0.983288506607067 miRanda -0.501174403959628 0.00199511489817876 NA NA NA hsa-miR-361-5p GABRP 0.971859117235239 5.30236555707088e-09 0.0195783716200864 0.983288506607067 miRanda -1.13205217968851 2.63106911510218e-05 NA NA NA hsa-miR-28-5p GALNT10 0.230152919654905 0.0742909586754846 -0.206145398082523 0.413288257047077 miRanda -0.411463985944403 2.15099629595253e-05 NA NA NA hsa-miR-28-5p GALNT6 0.230152919654905 0.0742909586754846 1.76359237057375 2.04272359421186e-06 miRanda -0.637498535488176 1.03547205885649e-05 NA NA NA hsa-miR-375 GAPT 1.13910305294079 0.0512283522214186 -1.642776416144 0.000109185964202035 miRanda -0.187500590791828 7.52141018576267e-08 NA NA NA hsa-miR-28-5p GAPVD1 0.230152919654905 0.0742909586754846 -0.171882492967418 0.153126966647418 miRanda -0.226481576264404 8.00092667291635e-07 NA NA NA hsa-miR-183-5p GAS1 4.19757025992371 4.79612296318304e-26 -2.1882386842391 0.000375177981793486 miRNAWalker2_validate -0.693742196979546 2.51632530581404e-25 NA NA NA hsa-miR-200b-3p GATA4 3.78235093249346 3.18343003239465e-14 0.21063442916978 0.736053452717422 miRNAWalker2_validate;miRTarBase -0.136018198140149 0.0204336181521647 NA NA NA hsa-miR-183-5p GATA6 4.19757025992371 4.79612296318304e-26 -3.38076408789276 2.92272151179456e-14 miRNAWalker2_validate -0.564297303815106 6.18122417443534e-31 NA NA NA hsa-miR-200a-3p GATA6 4.59434485520731 6.38952518573476e-18 -3.38076408789276 2.92272151179456e-14 miRNAWalker2_validate -0.432301626835901 2.23198455840703e-31 NA NA NA hsa-miR-155-5p GATM 1.20164021433135 0.00086170622431261 -1.38276651380812 0.00867347114743588 miRNAWalker2_validate -0.170021480950914 0.0160663758433203 NA NA NA hsa-miR-155-5p GCLC 1.20164021433135 0.00086170622431261 -0.628851908850902 0.040512794299237 miRNAWalker2_validate -0.189564747856113 3.15942050891343e-06 NA NA NA hsa-miR-28-5p GCNT3 0.230152919654905 0.0742909586754846 -1.26104523562607 0.0825306249932419 miRanda -0.71966027831345 0.0106586268304816 NA NA NA hsa-miR-28-5p GEMIN4 0.230152919654905 0.0742909586754846 0.0437326593661176 0.764041340975649 miRNAWalker2_validate -0.196376041015664 0.000454601711818092 NA NA NA hsa-miR-484 GFOD1 1.81844463411787 1.82951571230938e-15 -0.940659645129877 0.00660758228917747 miRNAWalker2_validate -0.464548632718993 2.99636449693172e-11 NA NA NA hsa-miR-142-3p GHR 2.75247908790621 1.45636065474764e-12 -3.38492582906153 8.02448227205103e-15 miRanda -0.163399868827137 0.00271425541508256 NA NA NA hsa-miR-361-5p GHR 0.971859117235239 5.30236555707088e-09 -3.38492582906153 8.02448227205103e-15 miRanda -0.907977785941464 1.08517830269139e-12 NA NA NA hsa-miR-421 GHR 1.17791565395543 6.78526676976629e-06 -3.38492582906153 8.02448227205103e-15 miRanda -0.407158287477524 7.31048308168014e-07 NA NA NA hsa-miR-429 GHR 4.48815175680773 2.44117492218206e-17 -3.38492582906153 8.02448227205103e-15 miRanda -0.353072088127256 6.98086999082263e-21 NA NA NA hsa-miR-455-5p GHR 2.2582442061694 1.43472128037398e-13 -3.38492582906153 8.02448227205103e-15 miRanda -0.288005479017098 2.99968917323832e-05 NA NA NA hsa-miR-491-5p GHR 0.615770352820862 0.0418295628761654 -3.38492582906153 8.02448227205103e-15 miRanda -0.252112855528744 0.00110544469002084 NA NA NA hsa-miR-28-5p GLG1 0.230152919654905 0.0742909586754846 -0.161589230031647 0.250025344474937 miRanda -0.179461044450605 0.000902859216443648 NA NA NA hsa-miR-28-5p GLIPR1 0.230152919654905 0.0742909586754846 -1.33750196699046 8.61857160192238e-05 miRanda -0.44988088681852 0.000695906677398546 NA NA NA hsa-miR-28-5p GLRX 0.230152919654905 0.0742909586754846 -0.275147826859437 0.316770480646163 miRanda -0.28732963500392 0.0068994002683012 NA NA NA hsa-miR-183-5p GLUL 4.19757025992371 4.79612296318304e-26 -0.784173404532954 0.000315027134440472 miRNAWalker2_validate -0.117119844026214 2.26150044882959e-06 NA NA NA hsa-miR-484 GLUL 1.81844463411787 1.82951571230938e-15 -0.784173404532954 0.000315027134440472 miRNAWalker2_validate -0.19705359602868 1.02388659674301e-05 NA NA NA hsa-miR-28-5p GNAI1 0.230152919654905 0.0742909586754846 -0.933113188508686 0.00215390088538223 miRanda -0.370769842081501 0.00169557755940728 NA NA NA hsa-miR-21-5p GNAQ 2.73773305747971 1.38864982139576e-43 -0.920867362350762 2.21629171433551e-07 miRNAWalker2_validate -0.215913968610852 4.20015668548295e-08 NA NA NA hsa-miR-155-5p GNAS 1.20164021433135 0.00086170622431261 0.388193243929576 0.00520707662929937 miRNAWalker2_validate -0.117347221685191 1.05447248451717e-10 NA NA NA hsa-miR-425-5p GNB5 3.07071373939774 4.02947460586085e-25 -0.839186629235185 5.42372549345636e-07 miRNAWalker2_validate -0.190730698510053 4.96622354891869e-14 NA NA NA hsa-miR-28-5p GNG12 0.230152919654905 0.0742909586754846 -1.00694431810149 1.61985728260734e-06 miRanda -0.199366829360215 0.0154269432421396 NA NA NA hsa-miR-28-5p GNG2 0.230152919654905 0.0742909586754846 -1.3576212262363 2.04502229623169e-05 miRanda -0.393158661465059 0.00157741925316573 NA NA NA hsa-miR-21-5p GOLGA4 2.73773305747971 1.38864982139576e-43 -0.317194372086961 0.0590619148533566 miRNAWalker2_validate -0.157996696077809 1.91514022543744e-05 NA NA NA hsa-miR-148a-3p GOLIM4 1.26728238710376 2.52325607402829e-06 -0.331903157967958 0.267387297718771 miRNAWalker2_validate -0.136109039726202 0.0107067593566668 NA NA NA hsa-miR-155-5p GPAM 1.20164021433135 0.00086170622431261 0.162591001560469 0.432101573917897 miRNAWalker2_validate -0.131372082240963 1.50922809865514e-06 NA NA NA hsa-miR-21-5p GPAM 2.73773305747971 1.38864982139576e-43 0.162591001560469 0.432101573917897 miRNAWalker2_validate -0.210719878160927 3.47628708058676e-06 NA NA NA hsa-miR-21-5p GPD1L 2.73773305747971 1.38864982139576e-43 -1.18117958887406 0.000269533833941388 miRNAWalker2_validate -0.503205714257579 9.77844362449467e-13 NA NA NA hsa-let-7a-5p GPM6B 0.618599506841644 2.76973453058748e-05 -2.38616048413304 8.19968989398376e-13 miRNAWalker2_validate -0.639107538380358 1.30274360993798e-08 NA NA NA hsa-let-7b-5p GPM6B 0.604314269683977 0.00140009936153214 -2.38616048413304 8.19968989398376e-13 miRNAWalker2_validate -0.395923487787279 6.41189252957105e-06 NA NA NA hsa-let-7e-5p GPM6B 0.860104282510173 6.04758298373779e-05 -2.38616048413304 8.19968989398376e-13 miRNAWalker2_validate -0.555326500636128 1.683980745969e-13 NA NA NA hsa-miR-28-5p GPM6B 0.230152919654905 0.0742909586754846 -2.38616048413304 8.19968989398376e-13 miRanda -0.416158782950193 0.00171207182596384 NA NA NA hsa-miR-320a GPM6B 0.438165828017084 0.0390159073347133 -2.38616048413304 8.19968989398376e-13 miRanda -0.452142386216688 5.58085720594455e-09 NA NA NA hsa-miR-320b GPM6B 1.55692969039548 1.41071034251915e-08 -2.38616048413304 8.19968989398376e-13 miRanda -0.324131695339368 3.58197163445174e-08 NA NA NA hsa-miR-590-3p GPM6B 2.59289455139753 1.03200520972022e-21 -2.38616048413304 8.19968989398376e-13 miRanda -0.264465571200039 9.0457085054087e-06 NA NA NA hsa-miR-590-5p GPM6B 3.18300989862077 2.06813568597893e-26 -2.38616048413304 8.19968989398376e-13 miRanda -0.309900355321623 4.14993090657228e-09 NA NA NA hsa-miR-324-5p GPX3 2.95683728155095 1.32960514360912e-20 -2.39528309379048 1.22905700762785e-07 miRanda -0.391239834912653 2.60154944867481e-09 NA NA NA hsa-miR-34c-5p GPX3 2.07190852984647 7.35776320806257e-08 -2.39528309379048 1.22905700762785e-07 miRanda -0.149730826671658 0.0137823230118704 NA NA NA hsa-miR-455-5p GPX3 2.2582442061694 1.43472128037398e-13 -2.39528309379048 1.22905700762785e-07 miRanda -0.204713729754438 0.00381316620809717 NA NA NA hsa-miR-92a-3p GPX3 2.06460102658973 1.44784291084757e-19 -2.39528309379048 1.22905700762785e-07 miRNAWalker2_validate -0.634066490765982 4.30128334051827e-12 NA NA NA hsa-miR-146b-5p GRAMD3 1.75587235896724 1.15724631266659e-07 0.377575088202135 0.080770663498056 miRanda -0.138356668343141 7.4696948498375e-06 NA NA NA hsa-miR-107 GREM2 1.30977326593435 1.30372468603965e-11 -4.9852150121131 1.5808751237327e-14 miRanda -0.808971187659974 7.86292571538348e-07 NA NA NA hsa-miR-26b-5p GREM2 0.885393662798425 3.2116297961629e-06 -4.9852150121131 1.5808751237327e-14 miRNAWalker2_validate -0.7079803912061 3.0938836192793e-05 NA NA NA hsa-miR-34c-5p GREM2 2.07190852984647 7.35776320806257e-08 -4.9852150121131 1.5808751237327e-14 miRanda -0.341504450115954 0.00010929005063195 NA NA NA hsa-miR-375 GREM2 1.13910305294079 0.0512283522214186 -4.9852150121131 1.5808751237327e-14 miRanda -0.125090407514171 0.0241183170018921 NA NA NA hsa-miR-375 GRIA3 1.13910305294079 0.0512283522214186 -2.06852702129128 7.47403992493886e-05 miRanda -0.157146486674959 0.000285095691578038 NA NA NA hsa-miR-28-5p GRM5 0.230152919654905 0.0742909586754846 0.914174644927818 0.0930451825869367 miRanda -0.517449140126501 0.0142824299264995 NA NA NA hsa-miR-28-5p GRPEL2 0.230152919654905 0.0742909586754846 0.607583048748918 3.5380273998549e-05 miRanda -0.135931270318372 0.0176396387204903 NA NA NA hsa-miR-129-5p GSN -0.524170159980738 0.222582956006346 -2.39108746525379 5.58907404692594e-22 miRanda -0.106785849438904 0.000355639751933619 NA NA NA hsa-miR-335-5p GSN 1.77247705492746 2.22457658872091e-06 -2.39108746525379 5.58907404692594e-22 miRNAWalker2_validate -0.177386340402732 7.21379976989681e-08 NA NA NA hsa-miR-429 GSN 4.48815175680773 2.44117492218206e-17 -2.39108746525379 5.58907404692594e-22 miRanda -0.247161414532083 2.8540450362452e-31 NA NA NA hsa-miR-28-5p GSTCD 0.230152919654905 0.0742909586754846 0.299372094990564 0.0944823443831872 miRanda -0.16406681573734 0.0179231794658357 NA NA NA hsa-miR-92b-3p GSTM3 1.20409245530001 3.41055816361655e-06 -1.3605986269989 0.0167833525161002 miRNAWalker2_validate -0.262583505053058 0.0130650040119571 NA NA NA hsa-miR-21-5p GTF2A1 2.73773305747971 1.38864982139576e-43 -0.43839369936176 0.177762306654447 miRNAWalker2_validate -0.230809118322953 0.00134485963239711 NA NA NA hsa-miR-21-5p GTF2I 2.73773305747971 1.38864982139576e-43 -0.0856751405368588 0.702571441096015 miRNAWalker2_validate -0.172305001443511 0.000500154580617234 NA NA NA hsa-miR-192-5p GULP1 2.69002528723195 1.22990188194432e-16 -2.32454882096863 5.13637317927748e-09 miRNAWalker2_validate -0.414617838404973 2.42531705195542e-13 NA NA NA hsa-miR-215-5p GULP1 2.30755467422978 2.38476032118039e-06 -2.32454882096863 5.13637317927748e-09 miRNAWalker2_validate -0.193077343958057 1.79497283520707e-06 NA NA NA hsa-miR-335-5p GULP1 1.77247705492746 2.22457658872091e-06 -2.32454882096863 5.13637317927748e-09 miRNAWalker2_validate -0.195297339368586 0.000151032704261476 NA NA NA hsa-miR-361-5p GULP1 0.971859117235239 5.30236555707088e-09 -2.32454882096863 5.13637317927748e-09 miRanda -0.769279246538293 2.30395858740208e-11 NA NA NA hsa-miR-362-3p GULP1 2.0756816987665 3.89026064579331e-12 -2.32454882096863 5.13637317927748e-09 miRanda -0.192230509572813 0.00364959908604459 NA NA NA hsa-miR-421 GULP1 1.17791565395543 6.78526676976629e-06 -2.32454882096863 5.13637317927748e-09 miRanda -0.234223025676832 0.00167942645618503 NA NA NA hsa-miR-429 GULP1 4.48815175680773 2.44117492218206e-17 -2.32454882096863 5.13637317927748e-09 miRanda -0.306040188859061 2.21885083366267e-19 NA NA NA hsa-miR-590-3p GULP1 2.59289455139753 1.03200520972022e-21 -2.32454882096863 5.13637317927748e-09 miRanda -0.360843917658847 2.68027869453498e-07 NA NA NA hsa-miR-28-5p GXYLT2 0.230152919654905 0.0742909586754846 -1.72430339748435 0.00323225716692418 miRanda -0.499032010775277 0.0287301152985621 NA NA NA hsa-miR-24-3p GYG2 0.99989036772428 1.35595013650376e-07 -1.04310956964085 0.0305280481092749 miRNAWalker2_validate -0.58744677140994 1.38842941366829e-06 NA NA NA hsa-miR-196a-5p HAND1 1.52993069622497 0.00397268663639603 -3.69455109115527 2.41984363208421e-08 miRNAWalker2_validate -0.131558722282067 0.0316048248604876 NA NA NA hsa-miR-375 HAS3 1.13910305294079 0.0512283522214186 0.304829249270265 0.570999843283982 miRanda -0.124188490426746 0.00511077386231337 NA NA NA hsa-miR-92a-3p HBB 2.06460102658973 1.44784291084757e-19 -2.21044345931558 1.97403866282154e-05 miRNAWalker2_validate -0.319676341628151 0.00268740449441431 NA NA NA hsa-miR-484 HCLS1 1.81844463411787 1.82951571230938e-15 -0.313203164352109 0.42414970255267 miRNAWalker2_validate -0.188085152377075 0.0196063840131016 NA NA NA hsa-miR-28-5p HDAC4 0.230152919654905 0.0742909586754846 -1.80036091395253 1.96398022917234e-18 miRanda -0.202517532784177 0.014829514267886 NA NA NA hsa-miR-28-5p HDAC5 0.230152919654905 0.0742909586754846 -0.940237255866815 1.73712796248924e-10 miRanda -0.300979110547788 1.65253275098748e-07 NA NA NA hsa-miR-21-5p HECTD1 2.73773305747971 1.38864982139576e-43 -0.495866206114041 0.000731018221736398 miRNAWalker2_validate -0.21348095000252 2.24182190490145e-11 NA NA NA hsa-miR-28-5p HIF1A 0.230152919654905 0.0742909586754846 -0.0887083952652183 0.694448347585856 miRanda -0.410823482574077 2.0450455286232e-06 NA NA NA hsa-miR-484 HIPK1 1.81844463411787 1.82951571230938e-15 -0.588594574596674 4.21218190967538e-05 miRNAWalker2_validate -0.148954080800683 3.96352171398938e-07 NA NA NA hsa-miR-20b-5p HIPK3 2.07706563022469 1.10107236083433e-05 -1.74508965708072 2.92750932105647e-06 miRNAWalker2_validate;miRTarBase -0.161028364081188 2.2394334248523e-05 NA NA NA hsa-miR-28-5p HIPK3 0.230152919654905 0.0742909586754846 -1.74508965708072 2.92750932105647e-06 miRanda -0.403356947409928 0.00581768258366771 NA NA NA hsa-miR-183-5p HLA-A 4.19757025992371 4.79612296318304e-26 0.259617019722684 0.411713479588845 miRNAWalker2_validate -0.18960226461633 1.03693786945693e-07 NA NA NA hsa-miR-28-5p HLA-DQB1 0.230152919654905 0.0742909586754846 -0.0962979320031252 0.84216851663937 miRanda -0.371761770412432 0.0474669848755652 NA NA NA hsa-miR-28-5p HLA-F 0.230152919654905 0.0742909586754846 0.0884684181724635 0.824283197005505 miRanda -0.376394035798423 0.0147205028745846 NA NA NA hsa-miR-429 HLF 4.48815175680773 2.44117492218206e-17 -5.48181644757567 4.24267397704754e-28 miRanda -0.451259357440866 1.83888287333809e-24 NA NA NA hsa-miR-486-5p HLF -0.194913133034028 0.607377798807705 -5.48181644757567 4.24267397704754e-28 miRanda -0.186163872158686 0.00634380083380656 NA NA NA hsa-miR-491-5p HLF 0.615770352820862 0.0418295628761654 -5.48181644757567 4.24267397704754e-28 miRanda -0.361336755475359 7.55229644616321e-05 NA NA NA hsa-miR-590-3p HLF 2.59289455139753 1.03200520972022e-21 -5.48181644757567 4.24267397704754e-28 miRanda -0.882740281835991 2.24170783748719e-23 NA NA NA hsa-miR-28-5p HNRNPC 0.230152919654905 0.0742909586754846 0.148998315665356 0.0916534735421474 miRanda -0.111229174099751 0.000997467379565334 NA NA NA hsa-miR-484 HOXA11 1.81844463411787 1.82951571230938e-15 -0.779286751498244 0.0292176238744169 miRNAWalker2_validate -0.382128980983409 1.47730039738533e-07 NA NA NA hsa-miR-340-5p HOXA5 0.30282999308409 0.157744789519131 0.189757288716074 0.583395904525936 miRNAWalker2_validate -0.296851510092366 0.000152170926736502 NA NA NA hsa-miR-374b-5p HOXA5 0.0654362503857184 0.722673188879465 0.189757288716074 0.583395904525936 miRNAWalker2_validate -0.215218074861254 0.0194916712019045 NA NA NA hsa-miR-339-5p HOXA7 2.68710938429893 3.03134080808154e-16 -0.554389989238669 0.186957465960316 miRanda -0.125128265927545 0.036122562462711 NA NA NA hsa-miR-423-5p HOXA7 0.963563145758616 9.86109015204915e-07 -0.554389989238669 0.186957465960316 miRNAWalker2_validate -0.248077509180457 0.016172248085571 NA NA NA hsa-miR-126-3p HOXA9 1.6384689127743 1.4473425456641e-10 -0.997610561961181 0.0549612762571718 miRNAWalker2_validate;miRTarBase -0.218101564844963 0.0243960423067604 NA NA NA hsa-miR-324-5p HOXA9 2.95683728155095 1.32960514360912e-20 -0.997610561961181 0.0549612762571718 miRNAWalker2_validate;miRanda -0.148505471272015 0.0499348456838557 NA NA NA hsa-miR-96-5p HOXA9 4.89433085814374 1.92000659886961e-31 -0.997610561961181 0.0549612762571718 miRNAWalker2_validate -0.131733049863846 0.0211399331969366 NA NA NA hsa-miR-28-5p HOXB9 0.230152919654905 0.0742909586754846 1.68746729415778 0.00260057817588281 miRanda -0.500693673530575 0.0218324942722427 NA NA NA hsa-miR-142-3p HPGD 2.75247908790621 1.45636065474764e-12 -1.85801320446886 0.0150344567090956 miRanda -0.500578214232237 4.42393203214532e-08 NA NA NA hsa-miR-146b-5p HPGD 1.75587235896724 1.15724631266659e-07 -1.85801320446886 0.0150344567090956 miRanda -0.997415083908675 2.44852194905578e-21 NA NA NA hsa-miR-217 HPGD 0.608024397387488 0.199352491710517 -1.85801320446886 0.0150344567090956 miRanda -0.418402478795246 1.38808821416938e-07 NA NA NA hsa-miR-375 HPGDS 1.13910305294079 0.0512283522214186 -2.91777973557625 3.3088782124051e-13 miRanda -0.153958121710792 5.24803999865845e-06 NA NA NA hsa-miR-125a-3p HPSE2 1.24490295132072 5.26925231010328e-06 -5.63175393681928 1.25563154472554e-15 miRanda -0.589355165050012 3.73435854389028e-06 NA NA NA hsa-miR-542-3p HPSE2 1.18832665895751 1.98700670691565e-07 -5.63175393681928 1.25563154472554e-15 miRanda -0.396588569164595 0.00978955079706517 NA NA NA hsa-miR-590-5p HPSE2 3.18300989862077 2.06813568597893e-26 -5.63175393681928 1.25563154472554e-15 miRanda -1.36782594408405 9.54024251188114e-40 NA NA NA hsa-miR-28-5p HS3ST3B1 0.230152919654905 0.0742909586754846 -0.639453810462205 0.183372048335563 miRanda -0.859594115092429 3.23447623733742e-06 NA NA NA hsa-miR-125a-3p HSPB2 1.24490295132072 5.26925231010328e-06 -2.85103050430616 3.53689461443957e-14 miRanda -0.324533875891708 1.6628722642631e-06 NA NA NA hsa-miR-125a-5p HSPB2 0.599529391575274 0.0102300147180307 -2.85103050430616 3.53689461443957e-14 miRanda -0.205128074645213 0.0112414765028265 NA NA NA hsa-miR-17-5p HSPB2 3.2710598467455 9.93128340539455e-27 -2.85103050430616 3.53689461443957e-14 miRNAWalker2_validate -0.610537075865828 9.22009402702774e-30 NA NA NA hsa-miR-375 HTR7 1.13910305294079 0.0512283522214186 -0.852837432457614 0.175178303419063 miRanda -0.341563779348512 1.74284174308163e-11 NA NA NA hsa-miR-28-5p HUWE1 0.230152919654905 0.0742909586754846 -0.120828408136381 0.300031611729402 miRanda -0.119198715702616 0.00790761515572375 NA NA NA hsa-miR-28-5p IER3 0.230152919654905 0.0742909586754846 -1.98755640274994 1.10916967354809e-09 miRanda -0.36998002964117 0.00410338493351077 NA NA NA hsa-miR-129-5p IGF1 -0.524170159980738 0.222582956006346 -3.75951127345565 1.26264890381366e-10 miRanda -0.24872412851026 0.000279350666200339 NA NA NA hsa-miR-27a-3p IGF1 1.66542180327138 4.93775737894805e-13 -3.75951127345565 1.26264890381366e-10 miRNAWalker2_validate;miRTarBase -0.651692554274928 7.73576562076687e-08 NA NA NA hsa-miR-590-3p IGF1 2.59289455139753 1.03200520972022e-21 -3.75951127345565 1.26264890381366e-10 miRanda -0.845684857318828 5.27514597787573e-17 NA NA NA hsa-miR-484 IGF1R 1.81844463411787 1.82951571230938e-15 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate -0.282538218482723 1.04528421031889e-08 NA NA NA hsa-miR-362-3p IGF2 2.0756816987665 3.89026064579331e-12 0.0970288554818755 0.912383978798457 miRanda -0.408260903092568 0.00451278900607031 NA NA NA hsa-miR-375 IGFBP4 1.13910305294079 0.0512283522214186 -0.69029477845298 0.0129459532374433 miRanda -0.196394122600547 4.66836537136259e-19 NA NA NA hsa-miR-375 IGSF21 1.13910305294079 0.0512283522214186 -2.10951452385374 5.91415305612121e-05 miRanda -0.152734460657694 0.000458643158957581 NA NA NA hsa-miR-28-5p IKBKAP 0.230152919654905 0.0742909586754846 -0.100006792831437 0.430783588737347 miRanda -0.180735674140378 0.00020667271328109 NA NA NA hsa-miR-28-5p IL12RB2 0.230152919654905 0.0742909586754846 0.372769148854768 0.527723353953467 miRanda -0.892027875052874 8.7982151098267e-05 NA NA NA hsa-miR-28-5p IL13RA1 0.230152919654905 0.0742909586754846 0.185374242322141 0.289239058001587 miRanda -0.263393835936169 8.98444252679988e-05 NA NA NA hsa-miR-28-5p IL15RA 0.230152919654905 0.0742909586754846 -0.238342793156716 0.520044602405546 miRanda -0.537513460861848 0.000167517800221479 NA NA NA hsa-miR-155-5p IL17RB 1.20164021433135 0.00086170622431261 0.880836605350137 0.00937800355624759 miRNAWalker2_validate -0.148908219964358 0.00100999763778029 NA NA NA hsa-miR-28-5p IL20RB 0.230152919654905 0.0742909586754846 0.855893422954078 0.165732095073442 miRanda -0.815114289100964 0.000638003852855362 NA NA NA hsa-miR-28-5p IL27RA 0.230152919654905 0.0742909586754846 0.335920862322083 0.311033446739574 miRanda -0.309827403339989 0.0158840449709035 NA NA NA hsa-miR-375 IL2RA 1.13910305294079 0.0512283522214186 -0.168267799080654 0.754364221522117 miRanda -0.106576857812083 0.0163371615026233 NA NA NA hsa-miR-484 IMPA2 1.81844463411787 1.82951571230938e-15 -1.29361497349091 2.74008616067664e-05 miRNAWalker2_validate -0.273644113539484 1.66442148683029e-05 NA NA NA hsa-miR-28-5p IMPAD1 0.230152919654905 0.0742909586754846 -0.11761464975373 0.339680475784706 miRanda -0.129605068665521 0.0062893418849867 NA NA NA hsa-miR-155-5p INA 1.20164021433135 0.00086170622431261 1.89409263754523 0.0169012105920999 miRNAWalker2_validate -0.515907084258845 9.1547500090746e-07 NA NA NA hsa-miR-28-5p INHBB 0.230152919654905 0.0742909586754846 -1.63532338824153 1.3666012569742e-06 miRanda -0.32653293249237 0.0140155929201986 NA NA NA hsa-miR-28-5p IPO5 0.230152919654905 0.0742909586754846 -0.243522410713539 0.0499772337714082 miRanda -0.209811978173035 1.04022770779956e-05 NA NA NA hsa-miR-21-5p IPP 2.73773305747971 1.38864982139576e-43 -0.442609501076678 0.00931864204254622 miRNAWalker2_validate -0.157863287292683 2.59828235066014e-05 NA NA NA hsa-miR-28-5p IQGAP1 0.230152919654905 0.0742909586754846 -0.603312041728002 8.20581927698083e-05 miRanda -0.231819603303022 9.39457747934892e-05 NA NA NA hsa-miR-148a-3p IRS1 1.26728238710376 2.52325607402829e-06 -0.851786005843366 0.00822245753156005 miRNAWalker2_validate;miRTarBase -0.13458990463138 0.0196263890531715 NA NA NA hsa-miR-484 IRS2 1.81844463411787 1.82951571230938e-15 -0.911324412136108 0.0110242467169193 miRNAWalker2_validate -0.283040383204278 0.000119444416442488 NA NA NA hsa-miR-28-5p ISCA1 0.230152919654905 0.0742909586754846 -0.362416228871866 0.00249198845958823 miRanda -0.117070325301749 0.0116093955157535 NA NA NA hsa-miR-28-5p ISCA1P1 0.230152919654905 0.0742909586754846 -0.132382917361711 0.349603611458021 miRanda -0.144257851869688 0.00823167523181757 NA NA NA hsa-miR-28-5p ISG20 0.230152919654905 0.0742909586754846 0.0780786138729179 0.824022216193751 miRanda -0.338476391505636 0.0127790790947898 NA NA NA hsa-miR-28-5p ITGA3 0.230152919654905 0.0742909586754846 0.852637018409875 0.0199990226143567 miRanda -0.299073730322259 0.0358545627665129 NA NA NA hsa-miR-183-5p ITGA5 4.19757025992371 4.79612296318304e-26 -2.12715698251452 2.02033561007737e-09 miRNAWalker2_validate -0.526702139503683 4.90437317422702e-46 NA NA NA hsa-miR-28-5p ITGA5 0.230152919654905 0.0742909586754846 -2.12715698251452 2.02033561007737e-09 miRanda -0.372501632838063 0.00788860597768604 NA NA NA hsa-miR-484 ITGA5 1.81844463411787 1.82951571230938e-15 -2.12715698251452 2.02033561007737e-09 miRNAWalker2_validate -0.626000197827085 1.90555444898923e-18 NA NA NA hsa-miR-125a-5p ITGA7 0.599529391575274 0.0102300147180307 -3.00880253778842 7.00968987324051e-14 miRanda -0.28533355911411 0.000922109444108536 NA NA NA hsa-miR-326 ITGA7 0.715313016136042 0.0610265683213359 -3.00880253778842 7.00968987324051e-14 miRanda -0.106742139616392 0.0434648440415811 NA NA NA hsa-miR-330-5p ITGA7 1.15100069700871 4.85551805046014e-07 -3.00880253778842 7.00968987324051e-14 miRanda -0.671157673153213 1.76126560905712e-15 NA NA NA hsa-miR-339-5p ITGA7 2.68710938429893 3.03134080808154e-16 -3.00880253778842 7.00968987324051e-14 miRanda -0.39334196159986 7.89961842658608e-12 NA NA NA hsa-miR-362-3p ITGA7 2.0756816987665 3.89026064579331e-12 -3.00880253778842 7.00968987324051e-14 miRanda -0.23181509775738 0.000595391400199554 NA NA NA hsa-miR-183-5p ITGA8 4.19757025992371 4.79612296318304e-26 -5.02147349449935 9.74845705778211e-19 miRNAWalker2_validate -0.400283992373764 1.97245511590304e-09 NA NA NA hsa-miR-484 ITGA9 1.81844463411787 1.82951571230938e-15 -2.58466582885052 1.23539072812213e-10 miRNAWalker2_validate -0.388080687503693 3.64799786304943e-06 NA NA NA hsa-miR-183-5p ITGB1 4.19757025992371 4.79612296318304e-26 -0.317990264846452 0.0583538962479715 miRNAWalker2_validate;miRTarBase -0.112552819137231 2.29750481257299e-09 NA NA NA hsa-miR-28-5p ITGB3 0.230152919654905 0.0742909586754846 -2.36514018822678 1.11882034713806e-07 miRanda -0.505515973751828 0.00392489144918646 NA NA NA hsa-miR-107 ITM2A 1.30977326593435 1.30372468603965e-11 -3.21947290829217 1.14940782210001e-16 miRanda -0.622273541718755 1.8298779493379e-10 NA NA NA hsa-miR-125a-3p ITM2A 1.24490295132072 5.26925231010328e-06 -3.21947290829217 1.14940782210001e-16 miRanda -0.360499741052898 2.87515905571729e-07 NA NA NA hsa-miR-26b-5p ITM2A 0.885393662798425 3.2116297961629e-06 -3.21947290829217 1.14940782210001e-16 miRNAWalker2_validate -0.492519253207225 1.33216093973867e-06 NA NA NA hsa-miR-375 ITM2A 1.13910305294079 0.0512283522214186 -3.21947290829217 1.14940782210001e-16 miRanda -0.139575749794043 2.50712860062103e-05 NA NA NA hsa-miR-429 ITM2A 4.48815175680773 2.44117492218206e-17 -3.21947290829217 1.14940782210001e-16 miRanda -0.380422027290023 5.34673846705356e-31 NA NA NA hsa-miR-590-3p ITM2A 2.59289455139753 1.03200520972022e-21 -3.21947290829217 1.14940782210001e-16 miRanda -0.411495316894919 3.22291060017156e-09 NA NA NA hsa-miR-590-5p ITM2A 3.18300989862077 2.06813568597893e-26 -3.21947290829217 1.14940782210001e-16 miRanda -0.484532763605161 2.06957225629233e-15 NA NA NA hsa-miR-183-5p ITPKB 4.19757025992371 4.79612296318304e-26 -1.70322432049595 4.43562078746451e-23 miRNAWalker2_validate -0.200698657589891 1.30804224784486e-24 NA NA NA hsa-miR-21-5p ITSN2 2.73773305747971 1.38864982139576e-43 0.0340532738024821 0.858851400959546 miRNAWalker2_validate -0.127377558194802 0.00259752317290461 NA NA NA hsa-miR-15b-5p JAK1 1.57112623124278 9.14247846750597e-13 -0.647144039203939 3.25551149817466e-06 miRNAWalker2_validate -0.202388635992569 6.7540767380457e-12 NA NA NA hsa-miR-28-5p JAK1 0.230152919654905 0.0742909586754846 -0.647144039203939 3.25551149817466e-06 miRanda -0.170979664648501 0.00160634337684464 NA NA NA hsa-miR-28-5p JKAMP 0.230152919654905 0.0742909586754846 0.241810772442414 0.0374716767861434 miRanda -0.203078962711204 4.93096570810499e-06 NA NA NA hsa-miR-28-5p JMJD1C 0.230152919654905 0.0742909586754846 -0.840910081913005 7.98664644216222e-07 miRanda -0.182792840712751 0.00614094911939772 NA NA NA hsa-miR-28-5p JMJD6 0.230152919654905 0.0742909586754846 -0.415812613423632 0.000460988415215552 miRanda -0.109152811227928 0.0177876422027157 NA NA NA hsa-miR-21-5p JMY 2.73773305747971 1.38864982139576e-43 -0.983838567989569 1.53426133793994e-09 miRNAWalker2_validate -0.339829380913669 2.33376966263599e-22 NA NA NA hsa-miR-21-5p JPH1 2.73773305747971 1.38864982139576e-43 -1.13031137878183 0.00577247424420099 miRNAWalker2_validate -0.280025592581863 0.00208897837938134 NA NA NA hsa-miR-15a-5p JUN 2.34669284378787 1.69544424500258e-23 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.322829003344663 1.37042285263916e-08 NA NA NA hsa-miR-155-5p KANK2 1.20164021433135 0.00086170622431261 -2.39251073906808 4.91460873675153e-20 miRNAWalker2_validate -0.107453660649635 0.00323836009792247 NA NA NA hsa-miR-375 KANK2 1.13910305294079 0.0512283522214186 -2.39251073906808 4.91460873675153e-20 miRanda -0.103674218167607 3.64805465784917e-06 NA NA NA hsa-miR-21-5p KBTBD7 2.73773305747971 1.38864982139576e-43 -0.562800644295925 0.0510947717663342 miRNAWalker2_validate -0.261152529381565 4.0929057195407e-05 NA NA NA hsa-miR-28-5p KCNC4 0.230152919654905 0.0742909586754846 -0.524737475349532 0.0688253015891529 miRanda -0.743834783536639 9.75111502028543e-12 NA NA NA hsa-miR-375 KCNN4 1.13910305294079 0.0512283522214186 1.56732934840806 0.000687387547369508 miRNAWalker2_validate -0.109918872183564 0.00410786831569081 NA NA NA hsa-miR-326 KCTD14 0.715313016136042 0.0610265683213359 0.898281965985512 0.0375161599626591 miRanda -0.163975695250664 0.00285323403753267 NA NA NA hsa-miR-98-5p KCTD14 1.11154309866014 1.24143909012085e-08 0.898281965985512 0.0375161599626591 miRNAWalker2_validate -0.371667480029464 0.00046467883752255 NA NA NA hsa-miR-28-5p KCTD15 0.230152919654905 0.0742909586754846 -1.06705874417742 0.00366825813765896 miRanda -0.452067359529983 0.00152200365355239 NA NA NA hsa-miR-183-5p KDELC2 4.19757025992371 4.79612296318304e-26 -0.714539871567231 0.00145605854632104 miRNAWalker2_validate -0.15595107084051 6.75013934075467e-10 NA NA NA hsa-miR-155-5p KDM3A 1.20164021433135 0.00086170622431261 0.111723025899627 0.466591188917887 miRNAWalker2_validate;miRTarBase -0.10446670224263 2.23228964318368e-07 NA NA NA hsa-miR-28-5p KIAA0100 0.230152919654905 0.0742909586754846 -0.0708768198898708 0.618573384740169 miRanda -0.117649881965926 0.0323428249463585 NA NA NA hsa-miR-155-5p KIAA0430 1.20164021433135 0.00086170622431261 -0.746195966712634 1.44948647002737e-09 miRNAWalker2_validate -0.126270383217661 6.59441168566457e-15 NA NA NA hsa-miR-375 KIAA0513 1.13910305294079 0.0512283522214186 -1.86789576149102 3.75602674217217e-12 miRNAWalker2_validate -0.10138397891433 7.36000870184637e-06 NA NA NA hsa-miR-28-5p KIAA1328 0.230152919654905 0.0742909586754846 -0.854090382218079 4.45354368594731e-08 miRanda -0.16235066037133 0.00808482768624728 NA NA NA hsa-miR-503-5p KIAA1671 3.66513190181895 6.60300917645278e-21 -1.1093190445168 7.85549761323763e-07 miRNAWalker2_validate -0.135788094028731 1.28800175553288e-06 NA NA NA hsa-miR-484 KIF1C 1.81844463411787 1.82951571230938e-15 -0.511231532854291 0.00121474686364031 miRNAWalker2_validate -0.14115185594248 1.26334213965224e-05 NA NA NA hsa-miR-125a-3p KIT 1.24490295132072 5.26925231010328e-06 -2.52159771280238 8.03290749995369e-07 miRanda -0.255118298636462 0.00509486668847337 NA NA NA hsa-miR-146b-5p KIT 1.75587235896724 1.15724631266659e-07 -2.52159771280238 8.03290749995369e-07 miRNAWalker2_validate -0.416813589432571 1.42119994915586e-08 NA NA NA hsa-miR-186-5p KIT 1.47445398888668 3.0781726595413e-15 -2.52159771280238 8.03290749995369e-07 miRNAWalker2_validate -0.659172130461391 3.65526184071893e-07 NA NA NA hsa-miR-193a-3p KIT 1.60460546928078 2.86169793322984e-07 -2.52159771280238 8.03290749995369e-07 miRanda -0.488922632123506 3.08444759163985e-10 NA NA NA hsa-miR-19a-3p KIT 3.42309334186656 3.02671914353412e-28 -2.52159771280238 8.03290749995369e-07 miRTarBase -0.492359170089366 2.58837661846889e-11 NA NA NA hsa-miR-20a-5p KIT 3.15577933619191 4.19753346442454e-25 -2.52159771280238 8.03290749995369e-07 miRTarBase -0.457576168379078 1.92521778037074e-09 NA NA NA hsa-miR-221-3p KIT 0.451556679024397 0.0909808299917811 -2.52159771280238 8.03290749995369e-07 miRNAWalker2_validate;miRTarBase -0.405149427467833 1.47261328620332e-05 NA NA NA hsa-miR-222-3p KIT 0.851783756239071 0.00266783568486918 -2.52159771280238 8.03290749995369e-07 miRNAWalker2_validate;miRTarBase -0.471589014167227 6.25441385275748e-08 NA NA NA hsa-miR-338-3p KIT 0.453166438193782 0.144583389707558 -2.52159771280238 8.03290749995369e-07 miRanda -0.213122500667458 0.0083854475397935 NA NA NA hsa-miR-342-3p KIT 1.49115144672245 1.43879249744621e-07 -2.52159771280238 8.03290749995369e-07 miRanda -0.498555598512948 6.78222503737131e-09 NA NA NA hsa-miR-421 KIT 1.17791565395543 6.78526676976629e-06 -2.52159771280238 8.03290749995369e-07 miRanda -0.238395717019672 0.0124890153451638 NA NA NA hsa-miR-590-3p KIT 2.59289455139753 1.03200520972022e-21 -2.52159771280238 8.03290749995369e-07 miRanda -0.519087288164396 5.92119981865176e-09 NA NA NA hsa-miR-103a-3p KLF4 1.44083190496858 1.53799939616416e-13 -2.66899133268835 3.11667300306613e-16 miRNAWalker2_validate;miRTarBase -0.370440513388653 5.99842226998452e-06 NA NA NA hsa-miR-107 KLF4 1.30977326593435 1.30372468603965e-11 -2.66899133268835 3.11667300306613e-16 miRNAWalker2_validate;miRTarBase;miRanda -0.258872045913521 0.00193400491856211 NA NA NA hsa-miR-125a-3p KLF4 1.24490295132072 5.26925231010328e-06 -2.66899133268835 3.11667300306613e-16 miRanda -0.135001285103939 0.0238699233032335 NA NA NA hsa-miR-128-3p KLF4 1.63756041666078 6.79626586407187e-14 -2.66899133268835 3.11667300306613e-16 miRNAWalker2_validate -0.354802185924886 1.03212168144704e-06 NA NA NA hsa-miR-130a-3p KLF4 2.02021855058359 1.26427102520415e-11 -2.66899133268835 3.11667300306613e-16 miRNAWalker2_validate;miRTarBase -0.150226355998753 0.00519061525415889 NA NA NA hsa-miR-25-3p KLF4 1.36472605225697 4.83790725935681e-11 -2.66899133268835 3.11667300306613e-16 miRNAWalker2_validate;miRTarBase -0.307848289222304 7.18251890931467e-05 NA NA NA hsa-miR-30b-5p KLF4 0.800822374912712 0.000133601914525413 -2.66899133268835 3.11667300306613e-16 miRNAWalker2_validate -0.162592608125637 0.0385357233744265 NA NA NA hsa-miR-335-5p KLF4 1.77247705492746 2.22457658872091e-06 -2.66899133268835 3.11667300306613e-16 miRNAWalker2_validate -0.125887930833515 0.00362252019576762 NA NA NA hsa-miR-429 KLF4 4.48815175680773 2.44117492218206e-17 -2.66899133268835 3.11667300306613e-16 miRanda -0.138617433153382 2.48477140811368e-06 NA NA NA hsa-miR-590-3p KLF4 2.59289455139753 1.03200520972022e-21 -2.66899133268835 3.11667300306613e-16 miRanda -0.229829794295701 0.000100090061909003 NA NA NA hsa-miR-21-5p KLF9 2.73773305747971 1.38864982139576e-43 -2.78806270116525 1.14874620908535e-18 miRNAWalker2_validate -0.279198801419409 0.000128964048959447 NA NA NA hsa-miR-28-5p KLHDC8A 0.230152919654905 0.0742909586754846 0.634587154815223 0.11393291322946 miRanda -0.305708257525987 0.0498837468634539 NA NA NA hsa-miR-21-5p KLHL15 2.73773305747971 1.38864982139576e-43 -1.08033359165148 4.67547886060464e-12 miRNAWalker2_validate -0.283653529233196 1.17616594031537e-16 NA NA NA hsa-miR-21-5p KLHL24 2.73773305747971 1.38864982139576e-43 0.029864699808801 0.876632918356684 miRNAWalker2_validate -0.167358804990014 7.68780703911249e-05 NA NA NA hsa-miR-28-5p KLK11 0.230152919654905 0.0742909586754846 -1.21479073032054 0.170808020467751 miRanda -1.42482911135294 3.05221473500512e-05 NA NA NA hsa-miR-28-5p KPNB1 0.230152919654905 0.0742909586754846 0.23017995660434 0.0495586398742705 miRanda -0.151315745509529 0.000790335992975752 NA NA NA hsa-miR-28-5p KRT1 0.230152919654905 0.0742909586754846 -1.17294574481659 0.23217285475221 miRanda -1.80563414289633 1.6621899901683e-06 NA NA NA hsa-miR-320a KRT14 0.438165828017084 0.0390159073347133 4.69485566292944 1.00924936988483e-05 miRanda -0.57348991514846 0.0203373664477168 NA NA NA hsa-miR-340-3p KRT15 0.596105654759215 0.0120949786600903 1.76625510200158 0.0143497818372619 miRNAWalker2_validate -0.348416417421155 0.0187680663879828 NA NA NA hsa-miR-491-5p KRT5 0.615770352820862 0.0418295628761654 1.16022205409748 0.300129929749631 miRanda -0.540416611060146 0.00492893347853098 NA NA NA hsa-miR-28-5p KRT6B 0.230152919654905 0.0742909586754846 2.92498728486826 0.0149954680826374 miRanda -2.6321446818775 1.07182040739399e-08 NA NA NA hsa-miR-28-5p KRT74 0.230152919654905 0.0742909586754846 0.795401727555843 0.146688228412347 miRanda -0.726226396781303 0.000607740901510315 NA NA NA hsa-miR-28-5p LAIR1 0.230152919654905 0.0742909586754846 -0.381838777209982 0.357273689898736 miRanda -0.349362892186364 0.029850243828098 NA NA NA hsa-miR-590-3p LAMA2 2.59289455139753 1.03200520972022e-21 -2.83761923067566 3.05345389505506e-15 miRanda -0.567223566221854 9.61700716671867e-20 NA NA NA hsa-miR-484 LAMB2 1.81844463411787 1.82951571230938e-15 -1.33584397067882 2.99365639027516e-08 miRNAWalker2_validate -0.432700661877785 3.04198926328285e-19 NA NA NA hsa-miR-330-5p LAMC3 1.15100069700871 4.85551805046014e-07 -2.92491806352548 5.56179940172618e-14 miRanda -0.217463020367138 0.0100115843333794 NA NA NA hsa-miR-21-5p LARS 2.73773305747971 1.38864982139576e-43 -0.227219713769769 0.0386633253182428 miRNAWalker2_validate -0.109529052857929 5.23211952891006e-06 NA NA NA hsa-miR-21-5p LATS1 2.73773305747971 1.38864982139576e-43 -0.728264634976516 0.00251777297344159 miRNAWalker2_validate -0.238133309919206 7.69461047041298e-06 25769949 miR 21 modulates resistance of HR HPV positive cervical cancer cells to radiation through targeting LATS1; By using dual luciferase assay we verified a binding site between miR-21 and 3'-UTR of large tumor suppressor kinase 1 LATS1; Through direct binding miR-21 can regulate LATS1 expression in cervical cancer cells; LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment drug resistance cervical and endocervical cancer hsa-miR-28-5p LBH 0.230152919654905 0.0742909586754846 0.0240918065859859 0.927864325672736 miRanda -0.20781851715833 0.0438402225373544 NA NA NA hsa-miR-28-5p LCE3D 0.230152919654905 0.0742909586754846 0.353746316448021 0.594280319534396 miRanda -1.57552024783137 4.31271637856307e-10 NA NA NA hsa-miR-155-5p LCORL 1.20164021433135 0.00086170622431261 0.110496379738905 0.541243213146296 miRNAWalker2_validate -0.111906952235718 2.74363892346609e-06 NA NA NA hsa-miR-21-5p LCORL 2.73773305747971 1.38864982139576e-43 0.110496379738905 0.541243213146296 miRNAWalker2_validate -0.112750939614132 0.00478922837764999 NA NA NA hsa-miR-125a-3p LDB2 1.24490295132072 5.26925231010328e-06 -1.93924406089212 1.49212008373556e-12 miRanda -0.178192645403004 0.000309554544158637 NA NA NA hsa-miR-26b-5p LDB2 0.885393662798425 3.2116297961629e-06 -1.93924406089212 1.49212008373556e-12 miRNAWalker2_validate -0.358081670959591 4.54629752438564e-07 NA NA NA hsa-miR-320a LDB2 0.438165828017084 0.0390159073347133 -1.93924406089212 1.49212008373556e-12 miRanda -0.157846607207991 0.0148085921565155 NA NA NA hsa-miR-320b LDB2 1.55692969039548 1.41071034251915e-08 -1.93924406089212 1.49212008373556e-12 miRanda -0.34830779086434 2.73292007421353e-13 NA NA NA hsa-miR-361-5p LDB2 0.971859117235239 5.30236555707088e-09 -1.93924406089212 1.49212008373556e-12 miRanda -0.532492304474678 2.7794662121867e-11 NA NA NA hsa-miR-362-3p LDB2 2.0756816987665 3.89026064579331e-12 -1.93924406089212 1.49212008373556e-12 miRanda -0.216396795300984 2.05016045963735e-06 NA NA NA hsa-miR-421 LDB2 1.17791565395543 6.78526676976629e-06 -1.93924406089212 1.49212008373556e-12 miRanda -0.302212239753243 3.21046083878231e-09 NA NA NA hsa-miR-590-3p LDB2 2.59289455139753 1.03200520972022e-21 -1.93924406089212 1.49212008373556e-12 miRanda -0.422365144870955 3.93938554904392e-19 NA NA NA hsa-miR-28-5p LDLRAD3 0.230152919654905 0.0742909586754846 0.387258458256556 0.265669721238659 miRanda -0.541832173117065 5.25838325465118e-05 NA NA NA hsa-miR-155-5p LDOC1 1.20164021433135 0.00086170622431261 -1.38511032286925 0.00378370931925676 miRNAWalker2_validate;miRTarBase -0.170201065500595 0.00795268851715935 NA NA NA hsa-miR-107 LEPR 1.30977326593435 1.30372468603965e-11 -2.12744323260056 3.5665835716367e-14 miRanda -0.366068596445827 2.19444529451667e-07 NA NA NA hsa-miR-146b-5p LEPR 1.75587235896724 1.15724631266659e-07 -2.12744323260056 3.5665835716367e-14 miRanda -0.113976473012636 0.00633031121575147 NA NA NA hsa-miR-320a LEPR 0.438165828017084 0.0390159073347133 -2.12744323260056 3.5665835716367e-14 miRanda -0.139029886519156 0.0371488495684245 NA NA NA hsa-miR-320b LEPR 1.55692969039548 1.41071034251915e-08 -2.12744323260056 3.5665835716367e-14 miRanda -0.216672793352074 1.49858366962403e-05 NA NA NA hsa-miR-326 LEPR 0.715313016136042 0.0610265683213359 -2.12744323260056 3.5665835716367e-14 miRanda -0.128036455334108 0.000498547117492919 NA NA NA hsa-miR-330-5p LEPR 1.15100069700871 4.85551805046014e-07 -2.12744323260056 3.5665835716367e-14 miRanda -0.287812081070877 1.86584777180135e-06 NA NA NA hsa-miR-335-5p LEPR 1.77247705492746 2.22457658872091e-06 -2.12744323260056 3.5665835716367e-14 miRNAWalker2_validate -0.188959683820175 2.40612389132049e-07 NA NA NA hsa-miR-342-3p LEPR 1.49115144672245 1.43879249744621e-07 -2.12744323260056 3.5665835716367e-14 miRanda -0.246846029882809 3.3231297547541e-07 NA NA NA hsa-miR-362-3p LEPR 2.0756816987665 3.89026064579331e-12 -2.12744323260056 3.5665835716367e-14 miRanda -0.333953001326403 4.2427007818558e-13 NA NA NA hsa-miR-421 LEPR 1.17791565395543 6.78526676976629e-06 -2.12744323260056 3.5665835716367e-14 miRanda -0.286701427794054 5.29452629971926e-08 NA NA NA hsa-miR-429 LEPR 4.48815175680773 2.44117492218206e-17 -2.12744323260056 3.5665835716367e-14 miRanda -0.17485208819106 1.61102498543535e-12 NA NA NA hsa-miR-590-3p LEPR 2.59289455139753 1.03200520972022e-21 -2.12744323260056 3.5665835716367e-14 miRanda -0.397712875655022 4.89737223453515e-16 NA NA NA hsa-miR-590-5p LEPR 3.18300989862077 2.06813568597893e-26 -2.12744323260056 3.5665835716367e-14 miRanda -0.3835321389588 1.07278748358036e-18 NA NA NA hsa-miR-877-5p LEPR 2.94916202082736 1.8151927276044e-13 -2.12744323260056 3.5665835716367e-14 miRNAWalker2_validate -0.279799975290776 5.72630876991385e-14 NA NA NA hsa-miR-28-5p LGI3 0.230152919654905 0.0742909586754846 -1.49184233589231 0.00457104070075613 miRanda -0.606161943508335 0.00302305106524006 NA NA NA hsa-miR-375 LGR5 1.13910305294079 0.0512283522214186 0.822108018087351 0.254769078971915 miRanda -0.158081045274495 0.00797380556765479 NA NA NA hsa-miR-107 LHFP 1.30977326593435 1.30372468603965e-11 -1.83125704677191 4.20141501543429e-10 miRanda -0.5938901122043 7.21401756245331e-17 NA NA NA hsa-miR-192-5p LHFP 2.69002528723195 1.22990188194432e-16 -1.83125704677191 4.20141501543429e-10 miRNAWalker2_validate -0.395416551289265 3.84130107766934e-22 NA NA NA hsa-miR-215-5p LHFP 2.30755467422978 2.38476032118039e-06 -1.83125704677191 4.20141501543429e-10 miRNAWalker2_validate -0.167992492184451 1.55532156071321e-08 NA NA NA hsa-miR-429 LHFP 4.48815175680773 2.44117492218206e-17 -1.83125704677191 4.20141501543429e-10 miRanda -0.271489275073573 1.75942107532583e-28 NA NA NA hsa-miR-491-5p LHFP 0.615770352820862 0.0418295628761654 -1.83125704677191 4.20141501543429e-10 miRanda -0.211851217087671 3.41833488543291e-05 NA NA NA hsa-miR-590-3p LHFP 2.59289455139753 1.03200520972022e-21 -1.83125704677191 4.20141501543429e-10 miRanda -0.459309621723829 4.87645207509922e-20 NA NA NA hsa-miR-590-5p LHFP 3.18300989862077 2.06813568597893e-26 -1.83125704677191 4.20141501543429e-10 miRanda -0.432999453362017 2.00384637621291e-22 NA NA NA hsa-miR-128-3p LIFR 1.63756041666078 6.79626586407187e-14 -2.63259527057529 1.38063075823569e-10 miRNAWalker2_validate -0.32751180955288 0.000292862139130524 NA NA NA hsa-miR-1296-5p LIFR 1.20556568733873 8.93601534401924e-06 -2.63259527057529 1.38063075823569e-10 miRNAWalker2_validate -0.18388289729969 0.01343697996703 NA NA NA hsa-miR-21-5p LIFR 2.73773305747971 1.38864982139576e-43 -2.63259527057529 1.38063075823569e-10 miRNAWalker2_validate -0.452730043258809 9.01193571383607e-07 NA NA NA hsa-miR-27a-3p LIFR 1.66542180327138 4.93775737894805e-13 -2.63259527057529 1.38063075823569e-10 miRNAWalker2_validate -0.497697732787467 4.38679516785295e-09 NA NA NA hsa-miR-320a LIFR 0.438165828017084 0.0390159073347133 -2.63259527057529 1.38063075823569e-10 miRanda -0.362817682240648 0.000157736572540311 NA NA NA hsa-miR-320b LIFR 1.55692969039548 1.41071034251915e-08 -2.63259527057529 1.38063075823569e-10 miRanda -0.309885396843237 1.91207258677968e-05 NA NA NA hsa-miR-335-5p LIFR 1.77247705492746 2.22457658872091e-06 -2.63259527057529 1.38063075823569e-10 miRNAWalker2_validate -0.276810251535744 1.7162625336088e-07 NA NA NA hsa-miR-429 LIFR 4.48815175680773 2.44117492218206e-17 -2.63259527057529 1.38063075823569e-10 miRanda -0.295067839492349 8.27778775358093e-17 NA NA NA hsa-miR-590-3p LIFR 2.59289455139753 1.03200520972022e-21 -2.63259527057529 1.38063075823569e-10 miRanda -0.273609486610872 0.00018369419146287 NA NA NA hsa-miR-98-5p LIFR 1.11154309866014 1.24143909012085e-08 -2.63259527057529 1.38063075823569e-10 miRNAWalker2_validate -0.518525972708098 3.94090734867525e-07 NA NA NA hsa-miR-28-5p LILRB4 0.230152919654905 0.0742909586754846 -0.154556534735054 0.784906689344267 miRanda -0.478389437969499 0.0293280260583979 NA NA NA hsa-miR-21-5p LIMCH1 2.73773305747971 1.38864982139576e-43 -1.21821537696325 0.00258022329543905 miRNAWalker2_validate -0.491703576065574 3.06469615923779e-08 NA NA NA hsa-miR-28-5p LIMK2 0.230152919654905 0.0742909586754846 0.816643093260764 8.52047121459764e-06 miRanda -0.143547263361181 0.045623976679201 NA NA NA hsa-miR-590-3p LIPE 2.59289455139753 1.03200520972022e-21 -0.583975879262377 0.0902160098236854 miRanda -0.185203602659012 0.00211279259986404 NA NA NA hsa-miR-503-5p LIX1L 3.66513190181895 6.60300917645278e-21 -1.29493279298234 2.01115053124561e-08 miRNAWalker2_validate -0.15920617148131 3.31044360439129e-08 NA NA NA hsa-miR-107 LMOD1 1.30977326593435 1.30372468603965e-11 -4.98176884690939 5.21861914982847e-20 miRanda -1.64510342701184 1.76006158855876e-37 NA NA NA hsa-miR-324-5p LMOD1 2.95683728155095 1.32960514360912e-20 -4.98176884690939 5.21861914982847e-20 miRanda -0.986109896164704 5.10433413740259e-39 NA NA NA hsa-miR-326 LMOD1 0.715313016136042 0.0610265683213359 -4.98176884690939 5.21861914982847e-20 miRanda -0.204269554134841 0.00487315580262842 NA NA NA hsa-miR-330-5p LMOD1 1.15100069700871 4.85551805046014e-07 -4.98176884690939 5.21861914982847e-20 miRanda -1.02790699226989 3.74348812311677e-19 NA NA NA hsa-miR-335-5p LMOD1 1.77247705492746 2.22457658872091e-06 -4.98176884690939 5.21861914982847e-20 miRNAWalker2_validate -0.391848967984297 4.98434079055731e-08 NA NA NA hsa-miR-421 LMOD1 1.17791565395543 6.78526676976629e-06 -4.98176884690939 5.21861914982847e-20 miRanda -0.799555741202632 3.97201396457215e-15 NA NA NA hsa-miR-155-5p LNX2 1.20164021433135 0.00086170622431261 -0.126871700008468 0.468377324967028 miRNAWalker2_validate -0.115921947450941 4.86790907706802e-07 NA NA NA hsa-miR-155-5p LONP2 1.20164021433135 0.00086170622431261 -0.378048006170258 0.00861983560305254 miRNAWalker2_validate -0.103075547746319 5.34011886821099e-08 NA NA NA hsa-miR-21-5p LONRF2 2.73773305747971 1.38864982139576e-43 -3.8642101573018 7.90463940348435e-08 miRNAWalker2_validate -1.42024037988097 5.44144130409695e-20 NA NA NA hsa-miR-484 LONRF2 1.81844463411787 1.82951571230938e-15 -3.8642101573018 7.90463940348435e-08 miRNAWalker2_validate -0.527841257970051 0.000430343280107338 NA NA NA hsa-miR-28-5p LOXL2 0.230152919654905 0.0742909586754846 0.752274659894764 0.0169514910560244 miRanda -0.455973906650758 0.000181459548210797 NA NA NA hsa-let-7b-5p LPL 0.604314269683977 0.00140009936153214 -0.979392473822279 0.0205546496369463 miRNAWalker2_validate -0.606975338059977 1.72313134555701e-08 NA NA NA hsa-miR-148b-3p LPL 1.97815018171325 6.07715327281595e-26 -0.979392473822279 0.0205546496369463 miRNAWalker2_validate -0.573241194142925 2.06941095329631e-08 NA NA NA hsa-miR-320a LPL 0.438165828017084 0.0390159073347133 -0.979392473822279 0.0205546496369463 miRanda -0.407966663275425 2.47242155166696e-05 NA NA NA hsa-miR-320b LPL 1.55692969039548 1.41071034251915e-08 -0.979392473822279 0.0205546496369463 miRanda -0.382934740656091 1.42712320387081e-07 NA NA NA hsa-miR-361-5p LPL 0.971859117235239 5.30236555707088e-09 -0.979392473822279 0.0205546496369463 miRanda -0.512925086345925 2.69504802287055e-05 NA NA NA hsa-miR-590-3p LPL 2.59289455139753 1.03200520972022e-21 -0.979392473822279 0.0205546496369463 miRanda -0.384754515933328 1.50474160688622e-07 NA NA NA hsa-miR-28-5p LRP10 0.230152919654905 0.0742909586754846 -0.626114792960359 0.000196715841989204 miRanda -0.238030515799184 0.000261944071598562 NA NA NA hsa-miR-21-5p LRRFIP1 2.73773305747971 1.38864982139576e-43 -1.15698960634805 2.40467433722313e-13 miRNAWalker2_validate;miRTarBase -0.183767244412151 2.43650690453709e-07 19559015 MicroRNA 21 targets LRRFIP1 and contributes to VM 26 resistance in glioblastoma multiforme; We further identified and validated LRRFIP1 whose product is an inhibitor of NF-kappaB signaling as a direct target gene of miR-21 drug resistance glioblastoma hsa-miR-28-5p LRRK2 0.230152919654905 0.0742909586754846 -3.1787789290057 4.20864823892524e-14 miRanda -0.407030703280861 0.0157145411364977 NA NA NA hsa-miR-28-5p LTBP2 0.230152919654905 0.0742909586754846 -0.171696713088545 0.611691558809232 miRanda -0.510527816128782 8.86775991512478e-05 NA NA NA hsa-miR-92b-3p LTBP3 1.20409245530001 3.41055816361655e-06 -1.05079618328153 2.50181833153369e-06 miRNAWalker2_validate -0.119234979060714 0.00433239302822899 NA NA NA hsa-miR-142-3p LTBP4 2.75247908790621 1.45636065474764e-12 -2.72677283547422 2.17815998844518e-20 miRanda -0.184020057619529 6.69137559413757e-07 NA NA NA hsa-miR-491-5p LTBP4 0.615770352820862 0.0418295628761654 -2.72677283547422 2.17815998844518e-20 miRanda -0.206329195324905 9.46378673441262e-05 NA NA NA hsa-miR-590-3p LTBP4 2.59289455139753 1.03200520972022e-21 -2.72677283547422 2.17815998844518e-20 miRanda -0.403785058183328 1.43125622445207e-14 NA NA NA hsa-miR-421 LTF 1.17791565395543 6.78526676976629e-06 -1.47600832824614 0.0741138990325635 miRanda -0.495165946919386 0.00113029819987338 NA NA NA hsa-miR-155-5p LUC7L3 1.20164021433135 0.00086170622431261 0.269965088141967 0.0674301073434878 miRNAWalker2_validate -0.139826600025986 2.69556940609174e-13 NA NA NA hsa-miR-28-5p LY6G6C 0.230152919654905 0.0742909586754846 1.75354498979901 0.00877475372979901 miRanda -1.05692325062112 4.3781909396775e-05 NA NA NA hsa-miR-21-5p LYRM7 2.73773305747971 1.38864982139576e-43 -0.698085407455151 3.71374122902277e-06 miRNAWalker2_validate -0.318341485292857 2.43732410830838e-23 NA NA NA hsa-miR-339-5p LYVE1 2.68710938429893 3.03134080808154e-16 -3.62791314374815 3.8852796247869e-17 miRanda -0.470644160181596 2.6589872126209e-14 NA NA NA hsa-miR-34c-5p LYVE1 2.07190852984647 7.35776320806257e-08 -3.62791314374815 3.8852796247869e-17 miRanda -0.223027661754929 0.000158037775238207 NA NA NA hsa-miR-455-5p LYVE1 2.2582442061694 1.43472128037398e-13 -3.62791314374815 3.8852796247869e-17 miRanda -0.365707666671895 8.27299127852216e-08 NA NA NA hsa-miR-590-3p LYVE1 2.59289455139753 1.03200520972022e-21 -3.62791314374815 3.8852796247869e-17 miRanda -0.667256229876465 8.07276593965635e-19 NA NA NA hsa-miR-375 MACROD2 1.13910305294079 0.0512283522214186 -0.7991426114361 0.164624719649376 miRanda -0.144866966068775 0.00224680499241233 NA NA NA hsa-miR-92b-3p MAFK 1.20409245530001 3.41055816361655e-06 -0.661166199079312 0.000124426949698985 miRNAWalker2_validate -0.129709551552234 4.85133040858944e-05 NA NA NA hsa-miR-146b-5p MAOA 1.75587235896724 1.15724631266659e-07 -1.3008372202964 0.0111582186160439 miRanda -0.572494801582301 1.31789688106457e-15 NA NA NA hsa-miR-590-3p MAOA 2.59289455139753 1.03200520972022e-21 -1.3008372202964 0.0111582186160439 miRanda -0.225557951676371 0.012201737395043 NA NA NA hsa-miR-590-5p MAOA 3.18300989862077 2.06813568597893e-26 -1.3008372202964 0.0111582186160439 miRanda -0.159404608473388 0.0475344563193645 NA NA NA hsa-miR-320a MAOB 0.438165828017084 0.0390159073347133 -4.31944111599063 3.90207430592244e-13 miRanda -0.788960382110758 1.30970139197968e-08 NA NA NA hsa-miR-320b MAOB 1.55692969039548 1.41071034251915e-08 -4.31944111599063 3.90207430592244e-13 miRanda -0.759011067964042 2.5308007996563e-13 NA NA NA hsa-miR-362-3p MAOB 2.0756816987665 3.89026064579331e-12 -4.31944111599063 3.90207430592244e-13 miRanda -0.310596116908956 0.00188340764092823 NA NA NA hsa-miR-421 MAOB 1.17791565395543 6.78526676976629e-06 -4.31944111599063 3.90207430592244e-13 miRanda -0.558739068293161 5.7283167245625e-07 NA NA NA hsa-miR-590-3p MAOB 2.59289455139753 1.03200520972022e-21 -4.31944111599063 3.90207430592244e-13 miRanda -0.784283800053845 5.26716651038064e-14 NA NA NA hsa-miR-28-5p MAP3K2 0.230152919654905 0.0742909586754846 -0.461416176318694 0.0183069160365383 miRanda -0.214332039714555 0.00466979679009669 NA NA NA hsa-miR-28-5p MAP3K3 0.230152919654905 0.0742909586754846 -0.867302315651695 4.69975718275905e-09 miRanda -0.210264267106694 0.000293317698661936 NA NA NA hsa-miR-484 MAP4 1.81844463411787 1.82951571230938e-15 -0.677894471246955 4.08007924790953e-07 miRNAWalker2_validate -0.179322950273508 4.29859984334467e-11 NA NA NA hsa-miR-28-5p MAP7D1 0.230152919654905 0.0742909586754846 -0.519333178125198 0.0019025932511054 miRanda -0.382873601239228 2.00131200196986e-09 NA NA NA hsa-miR-484 MAP7D1 1.81844463411787 1.82951571230938e-15 -0.519333178125198 0.0019025932511054 miRNAWalker2_validate -0.258692350294199 9.66104716685062e-15 NA NA NA hsa-miR-28-5p MARVELD1 0.230152919654905 0.0742909586754846 -0.862056682483319 0.00342527025665607 miRanda -0.416911741050829 0.000258151533025375 NA NA NA hsa-miR-28-5p MAST2 0.230152919654905 0.0742909586754846 -0.0668133437949496 0.699132759696502 miRanda -0.1976884409371 0.00302976975385311 NA NA NA hsa-miR-125a-3p MATN2 1.24490295132072 5.26925231010328e-06 -3.20506398822082 1.04689885829435e-12 miRanda -0.168158591698849 0.0393134144532455 NA NA NA hsa-miR-590-3p MATN2 2.59289455139753 1.03200520972022e-21 -3.20506398822082 1.04689885829435e-12 miRanda -0.394399845333776 8.75187282326446e-07 NA NA NA hsa-miR-590-5p MATN2 3.18300989862077 2.06813568597893e-26 -3.20506398822082 1.04689885829435e-12 miRanda -0.344754498029713 1.48667671356799e-06 NA NA NA hsa-miR-28-5p MAX 0.230152919654905 0.0742909586754846 -0.300810607733172 0.00220412918683644 miRanda -0.121010016036467 0.00138402325810049 NA NA NA hsa-miR-21-5p MBNL1 2.73773305747971 1.38864982139576e-43 -1.03715217368983 1.91023114600054e-14 miRNAWalker2_validate -0.140114849947808 4.94699113046209e-06 NA NA NA hsa-miR-155-5p MBNL3 1.20164021433135 0.00086170622431261 -1.39664025928726 7.58496847232093e-05 miRNAWalker2_validate -0.134353742811655 0.00465675650261959 NA NA NA hsa-miR-15a-5p MCL1 2.34669284378787 1.69544424500258e-23 -0.966384598042312 6.2852193244413e-09 miRNAWalker2_validate -0.107808676234929 0.00110378696128458 NA NA NA hsa-miR-21-5p MDM4 2.73773305747971 1.38864982139576e-43 -0.0417166726103293 0.796356265058254 miRNAWalker2_validate -0.177477843606092 5.08057823919745e-07 NA NA NA hsa-miR-28-5p MED6 0.230152919654905 0.0742909586754846 0.316383529893546 0.00577476898255331 miRanda -0.21106001853963 1.49770015021643e-06 NA NA NA hsa-miR-21-5p MEF2A 2.73773305747971 1.38864982139576e-43 -0.902731874686228 6.56581860630258e-09 miRNAWalker2_validate -0.202503337345031 4.33654871800665e-09 NA NA NA hsa-miR-28-5p MEF2A 0.230152919654905 0.0742909586754846 -0.902731874686228 6.56581860630258e-09 miRanda -0.156059176701255 0.0108474729276406 NA NA NA hsa-miR-21-5p MEF2C 2.73773305747971 1.38864982139576e-43 -2.13436808535659 1.07833769123274e-14 miRNAWalker2_validate;miRTarBase -0.349224895568138 2.20173424114234e-08 NA NA NA hsa-miR-484 MEGF8 1.81844463411787 1.82951571230938e-15 -0.60767532095613 0.000125342188710808 miRNAWalker2_validate -0.154382018800449 1.92775897421618e-06 NA NA NA hsa-miR-21-5p MEGF9 2.73773305747971 1.38864982139576e-43 -0.640753905897188 0.00228374865870751 miRNAWalker2_validate -0.193149135399811 3.19527986414261e-05 NA NA NA hsa-miR-155-5p MEIS1 1.20164021433135 0.00086170622431261 -1.88070168039709 1.5706323589883e-13 miRNAWalker2_validate;miRTarBase -0.229812843411991 2.04756744433688e-11 NA NA NA hsa-miR-21-5p MEIS1 2.73773305747971 1.38864982139576e-43 -1.88070168039709 1.5706323589883e-13 miRNAWalker2_validate -0.37653048064857 3.93704095725744e-11 NA NA NA hsa-miR-375 MEIS1 1.13910305294079 0.0512283522214186 -1.88070168039709 1.5706323589883e-13 miRanda -0.10533291150123 9.10439028847958e-07 NA NA NA hsa-miR-484 MEIS1 1.81844463411787 1.82951571230938e-15 -1.88070168039709 1.5706323589883e-13 miRNAWalker2_validate -0.344641826335037 7.11364566076702e-11 NA NA NA hsa-miR-28-5p METAP2 0.230152919654905 0.0742909586754846 -0.0608853666385034 0.595526468257848 miRanda -0.207837377854647 1.99278358896029e-06 NA NA NA hsa-miR-92b-3p METRN 1.20409245530001 3.41055816361655e-06 0.104068000315833 0.775110542960876 miRNAWalker2_validate -0.138375981855243 0.0405425237275009 NA NA NA hsa-miR-155-5p METTL7A 1.20164021433135 0.00086170622431261 -1.2467972694116 0.00312986563672727 miRNAWalker2_validate -0.391628272935353 1.24365471214466e-12 NA NA NA hsa-miR-129-5p MFAP4 -0.524170159980738 0.222582956006346 -4.25492223077246 2.17191646620062e-15 miRanda -0.223719799113719 0.000438933898672929 NA NA NA hsa-miR-34c-5p MFAP4 2.07190852984647 7.35776320806257e-08 -4.25492223077246 2.17191646620062e-15 miRanda -0.322196754815476 9.94209510994226e-06 NA NA NA hsa-miR-590-3p MFAP4 2.59289455139753 1.03200520972022e-21 -4.25492223077246 2.17191646620062e-15 miRanda -0.901382581354105 1.83891754873659e-22 NA NA NA hsa-miR-320a MFAP5 0.438165828017084 0.0390159073347133 -4.35255383201982 2.63926165947326e-07 miRanda -1.43338637040127 7.35428957194363e-14 NA NA NA hsa-miR-320b MFAP5 1.55692969039548 1.41071034251915e-08 -4.35255383201982 2.63926165947326e-07 miRanda -1.04335966481873 7.07998268068881e-13 NA NA NA hsa-miR-361-5p MFAP5 0.971859117235239 5.30236555707088e-09 -4.35255383201982 2.63926165947326e-07 miRanda -2.09385614084161 2.00201304351555e-18 NA NA NA hsa-miR-429 MFAP5 4.48815175680773 2.44117492218206e-17 -4.35255383201982 2.63926165947326e-07 miRanda -0.762359981181017 3.00075745420348e-27 NA NA NA hsa-miR-590-3p MFAP5 2.59289455139753 1.03200520972022e-21 -4.35255383201982 2.63926165947326e-07 miRanda -0.974824684043887 3.27543563578167e-11 NA NA NA hsa-miR-484 MFN2 1.81844463411787 1.82951571230938e-15 -0.62695413847527 2.60570986775671e-07 miRNAWalker2_validate -0.111446710756509 8.79322338106043e-06 NA NA NA hsa-miR-28-5p MFNG 0.230152919654905 0.0742909586754846 -1.26155590808676 3.90249969170828e-05 miRanda -0.268316487098029 0.0253475198303747 NA NA NA hsa-miR-21-5p MGA 2.73773305747971 1.38864982139576e-43 -0.155983744940662 0.299391978847023 miRNAWalker2_validate -0.172100161844827 1.56091542921271e-07 NA NA NA hsa-miR-21-5p MGAT4A 2.73773305747971 1.38864982139576e-43 -0.0233434427271035 0.934720712669718 miRNAWalker2_validate -0.14057487910173 0.0260947649124043 NA NA NA hsa-miR-155-5p MGST2 1.20164021433135 0.00086170622431261 0.139071658396039 0.543630587864055 miRNAWalker2_validate -0.195447034522806 6.10859719068923e-11 NA NA NA hsa-miR-21-5p MIB1 2.73773305747971 1.38864982139576e-43 -0.339857797544846 0.0363886788948554 miRNAWalker2_validate -0.123010763994947 0.000605752961491183 NA NA NA hsa-miR-375 MITF 1.13910305294079 0.0512283522214186 -2.11043666647908 2.14681139044162e-09 miRanda -0.127048912355923 1.63073750336725e-05 NA NA NA hsa-miR-129-5p MME -0.524170159980738 0.222582956006346 0.661801267443571 0.242557907574355 miRanda -0.135872580060682 0.0369273686667239 NA NA NA hsa-miR-361-5p MME 0.971859117235239 5.30236555707088e-09 0.661801267443571 0.242557907574355 miRanda -0.351056460068477 0.03289180612135 NA NA NA hsa-miR-429 MME 4.48815175680773 2.44117492218206e-17 0.661801267443571 0.242557907574355 miRanda -0.149348382330856 0.0025602454180051 NA NA NA hsa-miR-28-5p MMGT1 0.230152919654905 0.0742909586754846 -0.68742046704414 1.47427584314027e-05 miRanda -0.320344279156145 1.63256028803623e-07 NA NA NA hsa-miR-193a-3p MMRN1 1.60460546928078 2.86169793322984e-07 -3.80453799047884 3.52709253731147e-12 miRanda -0.424086966372641 6.16643028168515e-07 NA NA NA hsa-miR-324-5p MMRN1 2.95683728155095 1.32960514360912e-20 -3.80453799047884 3.52709253731147e-12 miRanda -0.775993284324143 1.10258096139159e-23 NA NA NA hsa-miR-330-5p MMRN1 1.15100069700871 4.85551805046014e-07 -3.80453799047884 3.52709253731147e-12 miRanda -0.548444961629002 2.83886310159197e-06 NA NA NA hsa-miR-335-5p MMRN1 1.77247705492746 2.22457658872091e-06 -3.80453799047884 3.52709253731147e-12 miRNAWalker2_validate -0.175586326750694 0.0144976474505372 NA NA NA hsa-miR-590-3p MMRN1 2.59289455139753 1.03200520972022e-21 -3.80453799047884 3.52709253731147e-12 miRanda -0.946415027011586 2.60536193282017e-24 NA NA NA hsa-miR-15a-5p MN1 2.34669284378787 1.69544424500258e-23 -2.44287385467581 8.2364144685939e-08 miRTarBase -0.780463940347888 2.56725877412989e-19 NA NA NA hsa-miR-21-5p MOAP1 2.73773305747971 1.38864982139576e-43 -1.0400964433585 2.62319898449648e-13 miRNAWalker2_validate -0.360281834389073 2.18350090147408e-33 NA NA NA hsa-miR-21-5p MON2 2.73773305747971 1.38864982139576e-43 -0.217487649016375 0.0952073706523079 miRNAWalker2_validate -0.142466985713673 5.69377819692068e-07 NA NA NA hsa-miR-21-5p MORC3 2.73773305747971 1.38864982139576e-43 -0.298173629571488 0.0653951052987779 miRNAWalker2_validate -0.102068293765625 0.00435608697430666 NA NA NA hsa-miR-15b-5p MPP1 1.57112623124278 9.14247846750597e-13 -1.1646568248169 0.00139878541621182 miRNAWalker2_validate -0.419614326100586 7.21526142035274e-08 NA NA NA hsa-miR-484 MPP2 1.81844463411787 1.82951571230938e-15 -1.4560422878474 0.000139696972689277 miRNAWalker2_validate -0.1710051567039 0.0310530982847113 NA NA NA hsa-miR-21-5p MRAP2 2.73773305747971 1.38864982139576e-43 -0.945322500598052 0.0549432972868521 miRNAWalker2_validate -0.415820534334657 0.000134172933551077 NA NA NA hsa-miR-28-5p MRC2 0.230152919654905 0.0742909586754846 -1.22225555548348 0.00028076073449382 miRanda -0.488415788114467 0.000185897072016894 NA NA NA hsa-miR-28-5p MRPL17 0.230152919654905 0.0742909586754846 0.868651815694624 2.28334667156143e-11 miRanda -0.140758726483113 0.00613785345475801 NA NA NA hsa-miR-28-5p MRPL37 0.230152919654905 0.0742909586754846 0.638840491815698 3.46548533693924e-06 miRanda -0.160336632950927 0.00281547124710972 NA NA NA hsa-miR-155-5p MSI2 1.20164021433135 0.00086170622431261 0.1018896569989 0.619558068853121 miRNAWalker2_validate -0.12853588364911 2.07963980930849e-06 NA NA NA hsa-miR-28-5p MSN 0.230152919654905 0.0742909586754846 -0.85546319996218 0.0136615174636227 miRanda -0.429993924831774 0.00138481190959104 NA NA NA hsa-miR-375 MSX2 1.13910305294079 0.0512283522214186 -0.626016759089203 0.185072002392091 miRanda -0.106050276602051 0.00651615067234756 NA NA NA hsa-miR-107 MT1M 1.30977326593435 1.30372468603965e-11 -2.82997238365431 4.28279967597688e-06 miRanda -0.934174312842555 5.72976255311401e-10 NA NA NA hsa-miR-26b-5p MT1M 0.885393662798425 3.2116297961629e-06 -2.82997238365431 4.28279967597688e-06 miRNAWalker2_validate -0.543654988754636 0.00058786299761877 NA NA NA hsa-miR-192-5p MT1X 2.69002528723195 1.22990188194432e-16 -0.158351243058968 0.729025301271932 miRNAWalker2_validate -0.326213817773193 4.87062994866744e-07 NA NA NA hsa-miR-326 MT1X 0.715313016136042 0.0610265683213359 -0.158351243058968 0.729025301271932 miRanda -0.199402707727663 0.000578512703728658 NA NA NA hsa-miR-330-5p MT1X 1.15100069700871 4.85551805046014e-07 -0.158351243058968 0.729025301271932 miRanda -0.196355370990291 0.0411249659669106 NA NA NA hsa-miR-28-5p MTF1 0.230152919654905 0.0742909586754846 -0.499080228357837 0.0010937181944664 miRanda -0.28637546742029 1.09331152943127e-06 NA NA NA hsa-miR-28-5p MTHFD2 0.230152919654905 0.0742909586754846 0.959238052648242 0.000126056354815021 miRanda -0.310856156684384 0.00141668397906536 NA NA NA hsa-miR-28-5p MTMR2 0.230152919654905 0.0742909586754846 -0.0692560870120555 0.555584242644447 miRanda -0.133960152374471 0.00301912885475374 NA NA NA hsa-miR-15b-5p MTMR6 1.57112623124278 9.14247846750597e-13 -0.522532018394334 4.81668326475859e-05 miRNAWalker2_validate -0.111345040479634 5.6820789187039e-05 NA NA NA hsa-miR-148a-3p MTMR9 1.26728238710376 2.52325607402829e-06 -0.836073789582016 3.17094975834284e-09 miRNAWalker2_validate -0.138272288967801 4.21657101621825e-08 NA NA NA hsa-miR-21-5p MTMR9 2.73773305747971 1.38864982139576e-43 -0.836073789582016 3.17094975834284e-09 miRNAWalker2_validate -0.212663859584212 7.67841002201062e-12 NA NA NA hsa-miR-28-5p MTSS1 0.230152919654905 0.0742909586754846 0.628093926051944 0.0271313698972097 miRanda -0.219959116435373 0.0464760594944676 NA NA NA hsa-miR-28-5p MUC5B 0.230152919654905 0.0742909586754846 -1.03565952156178 0.0929263872419541 miRanda -0.554149349667214 0.0205649165298005 NA NA NA hsa-miR-15a-5p MYBL1 2.34669284378787 1.69544424500258e-23 -0.198825078797647 0.492088677772154 miRNAWalker2_validate -0.134471932958031 0.0176248767818871 NA NA NA hsa-miR-15b-5p MYCBP2 1.57112623124278 9.14247846750597e-13 -0.799049389391067 3.8436887931124e-05 miRNAWalker2_validate -0.224905407339539 6.31008329723289e-08 NA NA NA hsa-miR-21-5p MYCBP2 2.73773305747971 1.38864982139576e-43 -0.799049389391067 3.8436887931124e-05 miRNAWalker2_validate -0.149402426598279 0.00054847239821412 NA NA NA hsa-miR-21-5p MYEF2 2.73773305747971 1.38864982139576e-43 -1.59030135823026 0.00334430439812949 miRNAWalker2_validate -0.767019296758877 8.82524514352792e-11 NA NA NA hsa-miR-28-5p MYH10 0.230152919654905 0.0742909586754846 -0.113066852038276 0.614876476546525 miRanda -0.225456311739036 0.00947559593122577 NA NA NA hsa-miR-107 MYH11 1.30977326593435 1.30372468603965e-11 -6.46900143887713 2.01880052077611e-19 miRanda -2.04095609021203 1.23369105078911e-32 NA NA NA hsa-miR-129-5p MYH11 -0.524170159980738 0.222582956006346 -6.46900143887713 2.01880052077611e-19 miRanda -0.358298746932948 2.96658186209931e-05 NA NA NA hsa-miR-146b-5p MYH11 1.75587235896724 1.15724631266659e-07 -6.46900143887713 2.01880052077611e-19 miRanda -0.219060349325955 0.0434784592800747 NA NA NA hsa-miR-193a-3p MYH11 1.60460546928078 2.86169793322984e-07 -6.46900143887713 2.01880052077611e-19 miRanda -0.587162592523105 2.375123444637e-07 NA NA NA hsa-miR-34c-5p MYH11 2.07190852984647 7.35776320806257e-08 -6.46900143887713 2.01880052077611e-19 miRanda -0.458881567105597 3.16964503844475e-06 NA NA NA hsa-miR-421 MYH11 1.17791565395543 6.78526676976629e-06 -6.46900143887713 2.01880052077611e-19 miRanda -0.984370791388743 2.8087231306107e-13 NA NA NA hsa-miR-491-5p MYH11 0.615770352820862 0.0418295628761654 -6.46900143887713 2.01880052077611e-19 miRanda -0.828934086240468 5.53026685011981e-11 NA NA NA hsa-miR-590-5p MYH11 3.18300989862077 2.06813568597893e-26 -6.46900143887713 2.01880052077611e-19 miRanda -1.49323559799567 8.81277300387581e-46 NA NA NA hsa-miR-107 MYLK 1.30977326593435 1.30372468603965e-11 -3.91755634527497 1.71047666943349e-18 miRanda -1.18584646924972 3.14478100232715e-28 NA NA NA hsa-miR-129-5p MYLK -0.524170159980738 0.222582956006346 -3.91755634527497 1.71047666943349e-18 miRanda -0.177822677863062 0.000872764838815631 NA NA NA hsa-miR-142-3p MYLK 2.75247908790621 1.45636065474764e-12 -3.91755634527497 1.71047666943349e-18 miRanda -0.152936432315784 0.00671623618881023 NA NA NA hsa-miR-193b-3p MYLK 2.25711804611899 4.1940744806631e-14 -3.91755634527497 1.71047666943349e-18 miRNAWalker2_validate -0.391979780548656 6.12171605435737e-08 NA NA NA hsa-miR-320a MYLK 0.438165828017084 0.0390159073347133 -3.91755634527497 1.71047666943349e-18 miRanda -0.919702242269842 3.337003248828e-19 NA NA NA hsa-miR-320b MYLK 1.55692969039548 1.41071034251915e-08 -3.91755634527497 1.71047666943349e-18 miRanda -0.848411878476523 3.88394315619199e-29 NA NA NA hsa-miR-34c-5p MYLK 2.07190852984647 7.35776320806257e-08 -3.91755634527497 1.71047666943349e-18 miRanda -0.243927352791597 6.91717478100386e-05 NA NA NA hsa-miR-429 MYLK 4.48815175680773 2.44117492218206e-17 -3.91755634527497 1.71047666943349e-18 miRanda -0.493949232662281 1.40981562735827e-40 NA NA NA hsa-miR-486-5p MYLK -0.194913133034028 0.607377798807705 -3.91755634527497 1.71047666943349e-18 miRanda -0.251045470881439 2.21236986319586e-05 NA NA NA hsa-miR-590-3p MYLK 2.59289455139753 1.03200520972022e-21 -3.91755634527497 1.71047666943349e-18 miRanda -0.848191229220407 1.04773319193505e-28 NA NA NA hsa-miR-590-5p MYLK 3.18300989862077 2.06813568597893e-26 -3.91755634527497 1.71047666943349e-18 miRanda -0.854826192672987 9.1770120952746e-38 NA NA NA hsa-miR-9-5p MYLK 1.02304182473283 0.042901377604859 -3.91755634527497 1.71047666943349e-18 miRNAWalker2_validate -0.170626094599343 0.000118590806256808 NA NA NA hsa-miR-28-5p MYO16 0.230152919654905 0.0742909586754846 -0.936422991991686 0.0595449925828967 miRanda -0.577383934502738 0.00271562967266049 NA NA NA hsa-miR-484 MYO5A 1.81844463411787 1.82951571230938e-15 -0.274576441491861 0.311620335084615 miRNAWalker2_validate -0.26835967693371 1.15950235780446e-06 NA NA NA hsa-miR-155-5p MYO6 1.20164021433135 0.00086170622431261 0.447732292238672 0.033989651113651 miRNAWalker2_validate -0.17546220180622 2.23092644252592e-10 NA NA NA hsa-miR-21-5p MYO9A 2.73773305747971 1.38864982139576e-43 -1.29622192336459 1.1786138431555e-06 miRNAWalker2_validate -0.365668589396931 4.94466268238182e-10 NA NA NA hsa-miR-324-5p MYOC 2.95683728155095 1.32960514360912e-20 -6.63759370536025 1.33067927739516e-30 miRanda -0.830761573736939 4.32655606433586e-22 NA NA NA hsa-miR-486-5p MYOC -0.194913133034028 0.607377798807705 -6.63759370536025 1.33067927739516e-30 miRanda -0.163664389898163 0.0397711541733536 NA NA NA hsa-miR-542-3p MYOC 1.18832665895751 1.98700670691565e-07 -6.63759370536025 1.33067927739516e-30 miRanda -0.586254890084652 6.25697419055384e-06 NA NA NA hsa-miR-590-3p MYOC 2.59289455139753 1.03200520972022e-21 -6.63759370536025 1.33067927739516e-30 miRanda -1.13373757484237 8.03303182596771e-29 NA NA NA hsa-miR-28-5p N4BP1 0.230152919654905 0.0742909586754846 0.111537134526603 0.402289544843355 miRNAWalker2_validate;miRTarBase -0.171849240783599 0.000790245701513697 NA NA NA hsa-miR-28-5p NAV1 0.230152919654905 0.0742909586754846 -0.418200324441875 0.108742163308665 miRanda -0.425745148436183 2.20630153610445e-05 NA NA NA hsa-miR-330-5p NAV3 1.15100069700871 4.85551805046014e-07 -3.21771083204903 7.35356644104861e-11 miRanda -0.631610651110153 1.51107538392867e-09 NA NA NA hsa-miR-339-5p NAV3 2.68710938429893 3.03134080808154e-16 -3.21771083204903 7.35356644104861e-11 miRanda -0.374235165556693 1.32122624165892e-07 NA NA NA hsa-miR-362-3p NAV3 2.0756816987665 3.89026064579331e-12 -3.21771083204903 7.35356644104861e-11 miRanda -0.294613791793873 0.000344612446013615 NA NA NA hsa-miR-429 NAV3 4.48815175680773 2.44117492218206e-17 -3.21771083204903 7.35356644104861e-11 miRanda -0.510454523466296 3.26870356813561e-36 NA NA NA hsa-miR-590-3p NAV3 2.59289455139753 1.03200520972022e-21 -3.21771083204903 7.35356644104861e-11 miRanda -0.573651305000193 3.57783139346242e-11 NA NA NA hsa-miR-21-5p NBEA 2.73773305747971 1.38864982139576e-43 -3.53497100925373 1.98262703308568e-12 miRNAWalker2_validate -0.739311763827703 4.39303876484564e-11 NA NA NA hsa-miR-375 NCAM1 1.13910305294079 0.0512283522214186 -5.46812766536887 2.35522582039703e-18 miRNAWalker2_validate;miRanda -0.129113378864319 0.0167812214639696 NA NA NA hsa-miR-28-5p NCBP1 0.230152919654905 0.0742909586754846 0.217858937867086 0.0887885669848608 miRanda -0.240423652602286 8.76399052860034e-07 NA NA NA hsa-miR-484 NCOA4 1.81844463411787 1.82951571230938e-15 -0.635322624047757 1.57921962021796e-05 miRNAWalker2_validate -0.140630711418387 3.1869154734375e-06 NA NA NA hsa-miR-484 NCS1 1.81844463411787 1.82951571230938e-15 -1.7356703955299 3.35229307090603e-12 miRNAWalker2_validate -0.367694544778982 7.49923428510573e-13 NA NA NA hsa-miR-28-5p NDE1 0.230152919654905 0.0742909586754846 -0.4579628171362 0.0222739891430977 miRanda -0.364578436064146 2.16330398865419e-06 NA NA NA hsa-miR-28-5p NDUFS4 0.230152919654905 0.0742909586754846 -0.442232352887805 0.00255017260020734 miRanda -0.134968668282172 0.0176390164320147 NA NA NA hsa-miR-21-5p NEK1 2.73773305747971 1.38864982139576e-43 -1.21543391235238 4.5206733879554e-13 miRNAWalker2_validate -0.287365517123975 9.39871663220959e-15 NA NA NA hsa-miR-484 NEK1 1.81844463411787 1.82951571230938e-15 -1.21543391235238 4.5206733879554e-13 miRNAWalker2_validate -0.232352510948601 2.11895159843983e-11 NA NA NA hsa-miR-28-5p NEK9 0.230152919654905 0.0742909586754846 -0.68505771922002 5.87748183701095e-07 miRanda -0.176767879727572 0.000957286225005285 NA NA NA hsa-miR-484 NEO1 1.81844463411787 1.82951571230938e-15 -0.77285961069625 0.00727512679084672 miRNAWalker2_validate -0.21644012408057 0.000252522378847755 NA NA NA hsa-miR-21-5p NFAT5 2.73773305747971 1.38864982139576e-43 -0.392833700410932 0.0377471321681522 miRNAWalker2_validate -0.137353463476768 0.0010230389162988 NA NA NA hsa-miR-484 NFE2L1 1.81844463411787 1.82951571230938e-15 -0.171483758009488 0.176829520001656 miRNAWalker2_validate -0.135094870961542 1.40596696454814e-07 NA NA NA hsa-miR-130b-3p NFIB 3.5350292994509 1.73934183852569e-27 -1.72909658442002 3.18902339154006e-09 miRNAWalker2_validate -0.136050849334352 0.00100420434981289 NA NA NA hsa-miR-19b-3p NFIB 2.49529833021187 1.57028265846699e-23 -1.72909658442002 3.18902339154006e-09 miRNAWalker2_validate -0.201545538889517 0.00022199296039601 NA NA NA hsa-miR-21-5p NFIB 2.73773305747971 1.38864982139576e-43 -1.72909658442002 3.18902339154006e-09 miRNAWalker2_validate;miRTarBase -0.422913483177233 6.02050397348431e-11 NA NA NA hsa-miR-429 NFIB 4.48815175680773 2.44117492218206e-17 -1.72909658442002 3.18902339154006e-09 miRanda -0.140437906210013 4.67518008105019e-08 NA NA NA hsa-miR-590-3p NFIB 2.59289455139753 1.03200520972022e-21 -1.72909658442002 3.18902339154006e-09 miRanda -0.147517072826912 0.00459022525550916 NA NA NA hsa-miR-590-5p NFIB 3.18300989862077 2.06813568597893e-26 -1.72909658442002 3.18902339154006e-09 miRanda -0.193330504366535 2.85202433596829e-05 NA NA NA hsa-miR-92a-3p NFIB 2.06460102658973 1.44784291084757e-19 -1.72909658442002 3.18902339154006e-09 miRNAWalker2_validate -0.181222446490432 0.00278661211417959 NA NA NA hsa-miR-93-5p NFIB 3.03961860136032 1.11672209617395e-24 -1.72909658442002 3.18902339154006e-09 miRNAWalker2_validate -0.185338325507574 4.88567265170685e-05 NA NA NA hsa-miR-28-5p NGB 0.230152919654905 0.0742909586754846 1.63208461683248 0.0129643202715091 miRanda -0.624820519909706 0.0144261969404177 NA NA NA hsa-miR-484 NHLRC2 1.81844463411787 1.82951571230938e-15 -0.640218884526469 0.00402772249098316 miRNAWalker2_validate -0.103654103580569 0.0240571917321543 NA NA NA hsa-miR-183-5p NHSL2 4.19757025992371 4.79612296318304e-26 -2.49632221478016 4.12641048639483e-09 miRNAWalker2_validate -0.342556937889041 1.18497938032959e-12 NA NA NA hsa-miR-28-5p NID1 0.230152919654905 0.0742909586754846 -0.986451929862748 0.00102953096063708 miRanda -0.364012825010224 0.00183376521016756 NA NA NA hsa-miR-21-5p NKTR 2.73773305747971 1.38864982139576e-43 0.352661252050677 0.0965248725207525 miRNAWalker2_validate -0.16012695559316 0.000638582663741228 NA NA NA hsa-miR-590-3p NLGN4X 2.59289455139753 1.03200520972022e-21 -1.4860212400363 0.00479917409443648 miRanda -0.345645169316373 0.000176791814347105 NA NA NA hsa-miR-28-5p NLRC5 0.230152919654905 0.0742909586754846 -0.00403114816697592 0.990433180502175 miRanda -0.351202189041928 0.00693150288473413 NA NA NA hsa-miR-28-5p NLRP3 0.230152919654905 0.0742909586754846 -1.77094514878564 1.97619437250516e-05 miRanda -0.511222130328263 0.00160862118486973 NA NA NA hsa-miR-28-5p NOTCH1 0.230152919654905 0.0742909586754846 -0.525528621196055 0.0318148804849282 miRanda -0.369077331402684 9.33153738807782e-05 NA NA NA hsa-miR-183-5p NOTCH2 4.19757025992371 4.79612296318304e-26 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate -0.186602968297905 5.5780628899393e-16 NA NA NA hsa-miR-155-5p NOVA1 1.20164021433135 0.00086170622431261 -4.21914714578111 7.21315612695789e-16 miRNAWalker2_validate -0.192455007772074 0.00792003456403439 NA NA NA hsa-miR-375 NOX4 1.13910305294079 0.0512283522214186 1.1573407399002 0.00254007513014407 miRanda -0.138933214769702 1.06277927341828e-05 NA NA NA hsa-miR-28-5p NPNT 0.230152919654905 0.0742909586754846 -0.653362201715566 0.124126335609346 miRanda -0.450075686250151 0.00626570103700779 NA NA NA hsa-miR-425-5p NPNT 3.07071373939774 4.02947460586085e-25 -0.653362201715566 0.124126335609346 miRNAWalker2_validate -0.180781290316181 0.00570976676703038 NA NA NA hsa-miR-125a-3p NPR1 1.24490295132072 5.26925231010328e-06 -2.53888070250993 2.43681989433353e-12 miRanda -0.213802946895797 0.00107673628774333 NA NA NA hsa-miR-320a NPR1 0.438165828017084 0.0390159073347133 -2.53888070250993 2.43681989433353e-12 miRNAWalker2_validate;miRTarBase -0.4303057184902 3.671844793339e-07 NA NA NA hsa-miR-590-3p NPR1 2.59289455139753 1.03200520972022e-21 -2.53888070250993 2.43681989433353e-12 miRanda -0.420848803326451 4.18289358726775e-11 NA NA NA hsa-miR-28-5p NPR3 0.230152919654905 0.0742909586754846 -1.7050337731335 0.000254565368348128 miRanda -0.47859518927014 0.00850630573964058 NA NA NA hsa-miR-21-5p NR2C2 2.73773305747971 1.38864982139576e-43 -0.0828502039991346 0.708270707720921 miRNAWalker2_validate -0.212618777676907 1.2399920878834e-05 NA NA NA hsa-miR-149-5p NR2F1 2.94200492826326 4.93436498919036e-14 -2.32010755035642 1.11261328622934e-10 miRNAWalker2_validate -0.150096306760607 0.000656284578352629 NA NA NA hsa-miR-181b-5p NR2F1 2.49307679431293 3.92829250217627e-20 -2.32010755035642 1.11261328622934e-10 miRNAWalker2_validate -0.259934781683594 3.14775186298243e-05 NA NA NA hsa-miR-196a-5p NR4A1 1.52993069622497 0.00397268663639603 -4.37235366597705 9.50064560522938e-27 miRNAWalker2_validate -0.15198162396951 0.000112144770862419 NA NA NA hsa-miR-107 NR4A2 1.30977326593435 1.30372468603965e-11 -3.24224269327175 3.42085666571771e-22 miRanda -0.177120595684481 0.0421422220434747 NA NA NA hsa-miR-19a-3p NR4A2 3.42309334186656 3.02671914353412e-28 -3.24224269327175 3.42085666571771e-22 miRNAWalker2_validate;miRTarBase -0.284011941393979 2.12773595241236e-08 NA NA NA hsa-miR-320b NR4A2 1.55692969039548 1.41071034251915e-08 -3.24224269327175 3.42085666571771e-22 miRanda -0.249250349420678 4.39879494904367e-05 NA NA NA hsa-miR-335-5p NR4A2 1.77247705492746 2.22457658872091e-06 -3.24224269327175 3.42085666571771e-22 miRNAWalker2_validate -0.123463978768543 0.00612825577594012 NA NA NA hsa-miR-342-3p NR4A2 1.49115144672245 1.43879249744621e-07 -3.24224269327175 3.42085666571771e-22 miRanda -0.132521744009111 0.0262174073792339 NA NA NA hsa-miR-34c-5p NR4A2 2.07190852984647 7.35776320806257e-08 -3.24224269327175 3.42085666571771e-22 miRanda -0.119649135326943 0.0103075218332136 NA NA NA hsa-miR-361-5p NR4A2 0.971859117235239 5.30236555707088e-09 -3.24224269327175 3.42085666571771e-22 miRanda -0.336845720863872 0.000978242321954781 NA NA NA hsa-miR-455-5p NR4A2 2.2582442061694 1.43472128037398e-13 -3.24224269327175 3.42085666571771e-22 miRanda -0.278161111734689 2.23450407869694e-07 NA NA NA hsa-miR-590-3p NR4A2 2.59289455139753 1.03200520972022e-21 -3.24224269327175 3.42085666571771e-22 miRanda -0.220642973622435 0.000337230290843335 NA NA NA hsa-miR-28-5p NRG1 0.230152919654905 0.0742909586754846 -1.2378190219847 0.0741741552249905 miRanda -0.792607124815608 0.00317446952106527 NA NA NA hsa-miR-484 NRIP2 1.81844463411787 1.82951571230938e-15 -1.44439378065645 2.33743322602013e-11 miRNAWalker2_validate -0.220066636344855 1.0394459686317e-06 NA NA NA hsa-miR-28-5p NRP1 0.230152919654905 0.0742909586754846 -0.612408058927576 0.0291452451283254 miRanda -0.415163627015125 0.000128260040477136 NA NA NA hsa-miR-28-5p NSD1 0.230152919654905 0.0742909586754846 -0.140278049651839 0.313165028415798 miRanda -0.238767125484218 7.27100039317821e-06 NA NA NA hsa-miR-28-5p NT5E 0.230152919654905 0.0742909586754846 -1.32095136217544 0.00557630949266939 miRanda -0.823725645066155 7.49568762265715e-06 NA NA NA hsa-miR-21-5p NTF3 2.73773305747971 1.38864982139576e-43 -3.30762378554694 2.95059143066034e-13 miRTarBase -0.718377718022019 1.14136463226806e-12 NA NA NA hsa-miR-28-5p NTNG1 0.230152919654905 0.0742909586754846 -4.11654002819262 1.71914221059989e-10 miRanda -0.53694399259983 0.0360024348538984 NA NA NA hsa-miR-107 NTRK2 1.30977326593435 1.30372468603965e-11 -3.4444884279512 9.02401971614574e-08 miRanda -1.10328807131129 2.46161403963682e-12 NA NA NA hsa-miR-125a-3p NTRK2 1.24490295132072 5.26925231010328e-06 -3.4444884279512 9.02401971614574e-08 miRanda -0.376033016875365 0.00107171920041796 NA NA NA hsa-miR-200c-3p NTRK2 3.50132673580082 2.42716349086937e-15 -3.4444884279512 9.02401971614574e-08 miRNAWalker2_validate;miRTarBase -0.558218294130396 5.1648144515451e-17 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-326 NTRK2 0.715313016136042 0.0610265683213359 -3.4444884279512 9.02401971614574e-08 miRanda -0.314908565253097 0.000146783251679974 NA NA NA hsa-miR-330-5p NTRK2 1.15100069700871 4.85551805046014e-07 -3.4444884279512 9.02401971614574e-08 miRanda -0.797396566610236 3.87824675584644e-09 NA NA NA hsa-miR-335-5p NTRK2 1.77247705492746 2.22457658872091e-06 -3.4444884279512 9.02401971614574e-08 miRNAWalker2_validate -0.306339245672051 0.000234367118729164 NA NA NA hsa-miR-339-5p NTRK2 2.68710938429893 3.03134080808154e-16 -3.4444884279512 9.02401971614574e-08 miRanda -0.473102823273484 2.60419080375085e-07 NA NA NA hsa-miR-342-3p NTRK2 1.49115144672245 1.43879249744621e-07 -3.4444884279512 9.02401971614574e-08 miRanda -0.232236997607975 0.0357997421714086 NA NA NA hsa-miR-361-5p NTRK2 0.971859117235239 5.30236555707088e-09 -3.4444884279512 9.02401971614574e-08 miRanda -1.17870891609401 2.52271895231875e-10 NA NA NA hsa-miR-429 NTRK2 4.48815175680773 2.44117492218206e-17 -3.4444884279512 9.02401971614574e-08 miRanda -0.439212754909065 2.46588001463114e-15 NA NA NA hsa-miR-590-3p NTRK2 2.59289455139753 1.03200520972022e-21 -3.4444884279512 9.02401971614574e-08 miRanda -0.620306339153694 4.06542783004907e-08 NA NA NA hsa-miR-590-5p NTRK2 3.18300989862077 2.06813568597893e-26 -3.4444884279512 9.02401971614574e-08 miRanda -0.735662775454248 1.39412676341035e-13 NA NA NA hsa-miR-28-5p NUAK1 0.230152919654905 0.0742909586754846 0.329626043944068 0.281541076624495 miRanda -0.305643714687695 0.00992092203739399 NA NA NA hsa-miR-28-5p NUAK2 0.230152919654905 0.0742909586754846 0.198061985670004 0.58300876635474 miRanda -0.846320227566852 6.72124231868533e-10 NA NA NA hsa-miR-21-5p NUBPL 2.73773305747971 1.38864982139576e-43 -0.252831815362486 0.060428087235297 miRNAWalker2_validate -0.1055722886714 0.000372509635720161 NA NA NA hsa-miR-28-5p NUP98 0.230152919654905 0.0742909586754846 -0.320845565576096 0.0038802181337346 miRanda -0.21757603548383 2.95363800656566e-07 NA NA NA hsa-miR-155-5p OBSCN 1.20164021433135 0.00086170622431261 -0.0849215500316562 0.804835244516279 miRNAWalker2_validate -0.181626487912547 6.79023588447868e-05 NA NA NA hsa-miR-129-5p OGN -0.524170159980738 0.222582956006346 -7.09619179560215 2.46506290591068e-18 miRanda -0.38613655394443 6.7959428562894e-05 NA NA NA hsa-miR-320a OGN 0.438165828017084 0.0390159073347133 -7.09619179560215 2.46506290591068e-18 miRanda -1.09348988031473 1.25398801987086e-08 NA NA NA hsa-miR-320b OGN 1.55692969039548 1.41071034251915e-08 -7.09619179560215 2.46506290591068e-18 miRanda -1.2627122393752 4.337395282287e-19 NA NA NA hsa-miR-361-5p OGN 0.971859117235239 5.30236555707088e-09 -7.09619179560215 2.46506290591068e-18 miRanda -2.04986845930167 4.70251029624899e-18 NA NA NA hsa-miR-429 OGN 4.48815175680773 2.44117492218206e-17 -7.09619179560215 2.46506290591068e-18 miRanda -0.71882135567577 1.33600397004873e-24 NA NA NA hsa-miR-590-3p OGN 2.59289455139753 1.03200520972022e-21 -7.09619179560215 2.46506290591068e-18 miRanda -1.400623706782 2.58418364399574e-23 NA NA NA hsa-miR-28-5p OLA1 0.230152919654905 0.0742909586754846 0.217879677771671 0.0767879435375223 miRanda -0.137182282557818 0.00383767494253703 NA NA NA hsa-miR-107 OLFM4 1.30977326593435 1.30372468603965e-11 -3.03146641021266 0.00511038403698769 miRanda -0.747724163903237 0.00524571179279947 NA NA NA hsa-miR-28-5p OLFML2A 0.230152919654905 0.0742909586754846 -1.0263532421833 0.000962903460469688 miRanda -0.462234486616528 0.00012533841921469 NA NA NA hsa-miR-21-5p OSBPL1A 2.73773305747971 1.38864982139576e-43 -1.28931675013637 1.82641604881751e-06 miRNAWalker2_validate -0.140051337757462 0.0210219724686477 NA NA NA hsa-miR-21-5p OSR1 2.73773305747971 1.38864982139576e-43 -2.00162314531515 0.000108440750546206 miRNAWalker2_validate -0.646520729765965 1.3783363624948e-08 NA NA NA hsa-miR-28-5p OTUD4 0.230152919654905 0.0742909586754846 -0.179933697233492 0.242508113903683 miRanda -0.154350074712088 0.00942638656310532 NA NA NA hsa-miR-28-5p PAFAH1B2 0.230152919654905 0.0742909586754846 -0.0796507734002518 0.73025873683242 miRanda -0.240258677693425 0.00714016770760452 NA NA NA hsa-miR-21-5p PALLD 2.73773305747971 1.38864982139576e-43 -2.68837995750497 4.71973205022663e-15 miRNAWalker2_validate -0.157580740005402 0.0458787961640147 NA NA NA hsa-miR-28-5p PALM2-AKAP2 0.230152919654905 0.0742909586754846 -1.62425751829219 3.00539592164251e-07 miRanda -0.471057109136506 0.000145967523587172 NA NA NA hsa-miR-361-5p PAMR1 0.971859117235239 5.30236555707088e-09 -3.2125579940755 2.37850548302422e-20 miRanda -0.438560691003339 3.05628146565995e-05 NA NA NA hsa-miR-93-3p PAMR1 2.85383869771942 5.64481766902125e-23 -3.2125579940755 2.37850548302422e-20 miRNAWalker2_validate -0.331626455119677 6.04092079735905e-09 NA NA NA hsa-miR-21-5p PAN3 2.73773305747971 1.38864982139576e-43 0.0733536614005788 0.602702925371984 miRNAWalker2_validate -0.132618911087181 1.76590249322683e-05 NA NA NA hsa-miR-28-5p PAPPA 0.230152919654905 0.0742909586754846 -1.75955305841573 0.000134461135734203 miRanda -0.749228231706814 2.78869198823715e-05 NA NA NA hsa-miR-28-5p PAQR5 0.230152919654905 0.0742909586754846 -0.0247252301101912 0.956044849342471 miRanda -0.462043927833899 0.00779113416574691 NA NA NA hsa-miR-155-5p PBRM1 1.20164021433135 0.00086170622431261 -0.397460214092907 0.00860947905394799 miRNAWalker2_validate -0.129215185464306 6.39318242151003e-11 NA NA NA hsa-miR-21-5p PBRM1 2.73773305747971 1.38864982139576e-43 -0.397460214092907 0.00860947905394799 miRNAWalker2_validate -0.247526067749202 2.9123046075582e-14 NA NA NA hsa-miR-21-5p PBX1 2.73773305747971 1.38864982139576e-43 -1.6697178635958 7.79697371332752e-08 miRNAWalker2_validate -0.479424721348102 2.23519725885048e-12 NA NA NA hsa-miR-28-5p PCGF5 0.230152919654905 0.0742909586754846 -0.764423238295416 4.61130231454902e-07 miRanda -0.128328704289286 0.0308951956838965 NA NA NA hsa-miR-92b-3p PCMTD1 1.20409245530001 3.41055816361655e-06 -0.379943623423606 0.0316348445152936 miRNAWalker2_validate -0.192190560305841 2.41119045507684e-09 NA NA NA hsa-miR-182-5p PCOLCE2 3.53923166221814 5.07781258121574e-21 -4.92842826125534 3.75529487642829e-16 miRNAWalker2_validate -0.73624117085977 4.47098337633947e-24 NA NA NA hsa-miR-192-5p PCOLCE2 2.69002528723195 1.22990188194432e-16 -4.92842826125534 3.75529487642829e-16 miRNAWalker2_validate -0.606048286267009 5.91028475860049e-12 NA NA NA hsa-miR-215-5p PCOLCE2 2.30755467422978 2.38476032118039e-06 -4.92842826125534 3.75529487642829e-16 miRNAWalker2_validate -0.270507643256401 1.6610105405234e-05 NA NA NA hsa-miR-26b-5p PCOLCE2 0.885393662798425 3.2116297961629e-06 -4.92842826125534 3.75529487642829e-16 miRNAWalker2_validate -1.06981263204918 7.75950385839484e-12 NA NA NA hsa-miR-590-3p PCOLCE2 2.59289455139753 1.03200520972022e-21 -4.92842826125534 3.75529487642829e-16 miRanda -0.603239174473175 2.63268512221241e-08 NA NA NA hsa-miR-28-5p PDCD1LG2 0.230152919654905 0.0742909586754846 -0.577757086604693 0.287866674080197 miRanda -0.915313504471392 1.1997998251401e-05 NA NA NA hsa-miR-21-5p PDCD4 2.73773305747971 1.38864982139576e-43 -1.01003448567123 1.45518644420808e-06 miRNAWalker2_validate;miRTarBase -0.317504309812522 4.65462729227789e-12 25575817;25316501;22072622;22267128;22322403;19836969;22212233;23604124;25520758;19682430;23272133;25477028;26252635;25994220;25991676;22747440;23827854;23824073;24865582;24902663;24888238;24149370;20978511;17991735;22689922;27355932;19308091;24331411;26169933;22547075;20372781;23558936;23201752;20815812;17968323;25310697;21842656;23567619;20581857;23888942;23548551;19013014;21685938;26142886;24472409;25973032;26418978;24659669;22086602;26212010;25543482;25543261;23904372;27725205;23564788;25400316;26150475;21546206;19509156;27035745;23052036;22353043;19633292;25566594;21412018;19276261;21330826;26864640;22335905;21636706 We identified miR-21 was directly downregulated by RBP2 and found that miR-21 downregulated PDCD4 expression in leukemia cells;MTCs were consistently associated with miR-21 up-regulation P < .0016 and featured significant PDCD4 nuclear down-regulation; An inverse correlation emerged between miR-21 overexpression and PDCD4 down-regulation P = .0013; This study showed in MTCs that miR-21 regulates PDCD4 expression and also that the miR-21/PDCD4 pathway correlates with clinicopathological variables and prognosis;Although microRNA-21 miR-21 is emerging as an oncogene and has been shown to target several tumor suppressor genes including programmed cell death 4 PDCD4 its precise mechanism of action on cancer stem cells CSCs is unclear; Herein we report that FOLFOX-resistant HCT-116 and HT-29 cells that are enriched in CSCs show a 3- to 7-fold upregulation of pre- and mature miR-21 and downregulation of PDCD4; Likewise overexpression of miR-21 in HCT-116 cells achieved through stable transfection led to the downregulation of PDCD4 and transforming growth factor beta receptor 2 TGFβR2;Prognostic significance of PDCD4 expression and association with microRNA 21 in each Dukes' stage of colorectal cancer patients; Furthermore relationships between the PDCD4 mRNA and microRNA-21 miR-21 were evaluated; The PDCD4 mRNA was investigated by the quantitative real-time RT-PCR method and miR-21 was examined by TaqMan microRNA assays; Significant inverse correlations were demonstrated between PDCD4 and miR-21;miR 21 promotes migration and invasion by the miR 21 PDCD4 AP 1 feedback loop in human hepatocellular carcinoma; The expression level of miR-21 was inversely correlated with the protein expression level of a previously identified target gene programmed cell death 4 PDCD4;This short review will focus on our recent finding that the microRNA miR-21 posttranscriptionally regulates Pdcd4 as well as invasion intravasation and metastasis;PDCD4 expression inversely correlated with miR 21 levels in gastric cancers;HBx mediated miR 21 upregulation represses tumor suppressor function of PDCD4 in hepatocellular carcinoma; HBx downregulates PDCD4 expression at least partially through miR-21; Taken together this study reported for the first time that HBx downregulates PDCD4 and upregulates miR-21 expression; The deregulation of PDCD4 by HBx through miR-21 represents a potential novel mechanism of the downregulation of PDCD4 in HBV-related HCC and provides new insights into HCC development;MicroRNA 21 Down regulates Rb1 Expression by Targeting PDCD4 in Retinoblastoma; MicroRNA-21 miR-21 possesses the oncogenic potential to target several tumor suppressor genes including PDCD4 and regulates tumor progression and metastasis; However the mechanism of how miR-21 regulates PDCD4 is poorly understood in RB; Using the TargetScan program we identified a list of potential target genes of these miRNAs of which PDCD4 is one the targets of miR-21; In this study we focused on the regulatory mechanism of miR-21 on PDCD4 in RB; We demonstrated an inverse correlation between miR-21 and PDCD4 expression in Weri-Rb1 and Y79 cells; These data suggest that miR-21 down-regulates Rb1 by targeting PDCD4 tumor suppressor;MicroRNA 21 promotes cell proliferation and down regulates the expression of programmed cell death 4 PDCD4 in HeLa cervical carcinoma cells; In this study we found that the inhibition of miR-21 in HeLa cervical cancer cells caused profound suppression of cell proliferation and up-regulated the expression of the tumor suppressor gene PDCD4;Additionally resveratrol increased the expression of tumor suppressors PDCD4 and maspin which are negatively regulated by miR-21; Short interfering si RNA against PDCD4 attenuated resveratrol's effect on prostate cancer cells and similar effects were observed following over expression of miR-21 with pre-miR-21 oligonucleotides; MiR-21 expression in these cells appeared to be dependent on Akt as LY294002 reduced the levels of miR-21 along with a concurrent increase in PDCD4 expression; These tumor- and metastatic-suppressive effects of resveratrol were associated with reduced miR-21 and pAkt and elevated PDCD4 levels;The expression of miR-21 and PDCD4 mRNA in transfected cells was quantified by real-time polymerase chain reaction and the expression of PDCD4 protein by Western blot; Cell proliferation apoptosis migration and invasion assays were performed to determine the biological effects of miR-21 expression and PDCD4 inhibition; Co-transfection of miR-21-sponge with PDCD4 siRNA upregulated miR-21 expression in these cells; PDCD4 mRNA and protein levels were increased 2.14-fold and 2.16-fold respectively following inhibition of miR-21 expression; Depletion of PDCD4 by siRNA transfection reversed the reduction of cell proliferation migration and invasion induced by inhibition of miR-21 in A549 cells; It indicates that miR-21 is highly expressed in patients with NSCLC and inhibition of miR-21 expression reduces proliferation migration and invasion of A549 cells by upregulating PDCD4 expression; Modulation of miR-21 or PDCD4 expression may provide a potentially novel therapeutic approach for NSCLC;IL 6 Inhibits the Targeted Modulation of PDCD4 by miR 21 in Prostate Cancer; In this study we evaluated the role of IL-6 in PDCD4 gene expression and how the microRNA miR-21 regulates this process in prostate cancer cell lines PC-3 and LNCaP; The expression of PDCD4 was inhibited by IL-6 but this effect was weakened in cell lines with low expression of miR-21; These findings support the feasibility of future efforts for diagnosis and gene therapy for prostate cancer that are based on IL-6 miR-21 and PDCD4;Furthermore the absence of miR-21 increased the expression of its target gene PDCD4 and subsequently modulated nuclear factor NF-κB activation;In this study using reverse phase protein arrays RPPAs we assessed MPS1 mediated cell signaling pathways and demonstrated that inhibiting MPS1 could upregulate the expression of the tumor suppressor PDCD4 and MSH2 genes by down regulating micro RNA-21 miR-21; We also show the prognostic effect of miR21 PDCD4 and MSH2 levels to patient survival across different GBM molecular subtypes;We also analyzed the immunohistochemical expression of PDCD4 an miR-21 gene target; PDCD4 expression was significantly downregulated in MTC samples consistent with miR-21 upregulation;Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA 21 mediated programmed cell death 4 PDCD4 expression; Further AR inhibition also increased PDCD4 a putative target of miR-21 in human colon cancer cells; Collectively these results indicate that AR inhibition prevents growth factor-induced colon cancer growth by down-regulating miR-21 expression and increasing PDCD4 levels through the reactive oxygen species ROS/AMPK/mTOR/AP1/4E-BP1 pathway;Berberine could inhibit miR-21 expression and function in ovarian cancer as shown by an enhancement of its target PDCD4 an important tumor suppressor in ovarian cancer;Overexpression of miR-21 in cisplatin sensitive cells decreased PDCD4 levels and increased cell proliferation;MicroRNA 21 miR 21 post transcriptionally downregulates tumor suppressor PDCD4 and promotes cell transformation proliferation and metastasis in renal cell carcinoma; MiR-21 induces neoplastic transformation cell proliferation and metastasis and downregulates programmed cell death4 PDCD4 in some cancers; The aim of this study was to investigate the roles and interactions of PDCD4 and miR-21 in human renal cell carcinoma RCC; The expression levels of PDCD4 protein and mRNA and miR-21 were examined by Western blot analysis and by qRT-PCR and luciferase reporter assays; MiR-21 not only promoted cancer cell hyperplasia and contributed to tumor cell transformation and metastasis but also post-transcriptionally downregulated PDCD4 protein expression; PDCD4 and miR-21 expression levels potentially play an important role in renal cell cancer;Programmed cell death 4 PDCD4 is a tumor suppressor gene whose expression is directly controlled by microRNA-21 miR-21; This PDCD4 and miR-21 inverse expression was also noted in cells and exosomes from OSC peritoneal effusions compared with nonneoplastic effusions; PDCD4 and miR-21 are involved in OSC oncogenesis;Finally in a subgroup of tumor specimens ROC curve analysis performed on quantitative PCR data sets for miR-21 ITGβ4 and PDCD4 shows that the combination of high miR-21 with low ITGβ4 and PDCD4 expression is able to predict presence of metastasis; In conclusion miR-21 is a key player in oncogenic EMT its overexpression is controlled by the cooperation of genetic and epigenetic alterations and its levels along with ITGβ4 and PDCD4 expression could be exploited as a prognostic tool for CRC metastasis;Transfection of anti-miR-21 rendered HCC cells sensitive to IFN-α/5-FU and such sensitivity was weakened by transfection of siRNAs of target molecules PETN and PDCD4 miR-21 expression in clinical HCC specimens was significantly associated with the clinical response to the IFN-α/5-FU combination therapy and survival rate;Programmed cell death 4 PDCD4 is an important functional target of the microRNA miR 21 in breast cancer cells;In ZD esophagus and tongue oncogenic miR-31 and miR-21 overexpression was accompanied by down-regulation of their respective tumor-suppressor targets PPP2R2A and PDCD4;Due to inhibition of miR-21 expression of the programed cell death 4 PDCD4 gene was promoted in tumors resulting in the induction of apoptosis of tumor cells;We also demonstrated that BMP-6-induced downregulation of miR-21 modified the activity of PDCD4 3'UTR and inhibited MDA-MB-231 cell invasion;The level of miR-21 was reversely correlated with the expression of PTEN and PDCD4 and positive correlated with PI3K/Akt pathway; miR-21 is involved in acquired resistance of EGFR-TKI in NSCLC which is mediated by down-regulating PTEN and PDCD4 and activating PI3K/Akt pathway;The results indicated that the miR-21 inhibition could induce the cell cycle arrest in G1 phase upregulate the expression of Programmed Cell Death Protein 4 PDCD4 and thus active the caspase-3 apoptosis pathway;Induction of miR-21 may enable cancer cells to elude DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repressing expression of PTEN and PDCD4;Clinicopathological and prognostic significance of PDCD4 and microRNA 21 in human gastric cancer; Recent studies have demonstrated that the novel tumor suppressor protein programmed cell death 4 PDCD4 is downregulated in several human solid cancer types and is suppressed by microRNA-21 miR-21; The objectives of this study were: i to establish the clinicopathological and prognostic significance of PDCD4 mRNA and ii to elucidate any correlation between PDCD4 mRNA and miR-21 in gastric cancer; We also performed an association study comparing PDCD4 mRNA and miR-21 in eight cell lines and 49 gastric cancers; An inverse correlation between PDCD4 mRNA and miR-21 was found in gastric cancer; Furthermore our findings suggest that PDCD4 mRNA is negatively regulated by miR-21 in gastric cancer and may serve as a target for effective therapies;Furthermore miR-21 mimic or inhibitor significantly reduced or increased the expression of PDCD4 and TPM1; MiR-21 is overexpressed in RCC tissue and modulates the growth apoptosis and cell cycle progression of RCC cells and regulates the expression of PDCD4 and TPM1;Moreover we demonstrate that oligonucleotide-mediated miR-21 silencing in U87 human GBM cells resulted in increased levels of the tumor suppressors PTEN and PDCD4 caspase 3/7 activation and decreased tumor cell proliferation;Curcumin treatment reduced miR-21 promoter activity and expression in a dose-dependent manner by inhibiting AP-1 binding to the promoter and induced the expression of the tumour suppressor Pdcd4 programmed cell death protein 4 which is a target of miR-21; Taken together this is the first paper to show that curcumin inhibits the transcriptional regulation of miR-21 via AP-1 suppresses cell proliferation tumour growth invasion and in vivo metastasis and stabilizes the expression of the tumour suppressor Pdcd4 in colorectal cancer;MicroRNA 21 miR 21 post transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion intravasation and metastasis in colorectal cancer; This is the first study to show that Pdcd4 is negatively regulated by miR-21;Inflammation and MiR 21 pathways functionally interact to downregulate PDCD4 in colorectal cancer; These findings indicate that miR-21 is a component of the COX-2 inflammation pathway and that this pathway promotes worsening of disease stage in colorectal cancer by inducing accumulation of PGE2 and increasing expression of miR-21 with consequent downregulation of the tumour suppressor gene PDCD4;The expression of miR-21 PTEN and PDCD4 were determined by Real-time PCR; Glossy ganoderma spore oil down-regulated the expression of miR-21 and up-regulated the expression of PTEN and PDCD4 significantly;Interestingly NVP-LDE-225 induced PDCD4 and apoptosis and inhibited cell viability by suppressing miR-21;PDCD4 a direct target gene of miR-21 could mediate chemoresistance to docetaxel in PC3 cells;Oxidative stress upregulates PDCD4 expression in patients with gastric cancer via miR 21; The expression of miR-21 and PDCD4 was highly correlated with the degree of differentiation tumor staging local lymphatic node metastasis and remote metastasis; In addition the relative expression of PDCD4 was negatively correlated with miR-21; Thus we conclude that ROS promotes gastric carcinogenesis via upregulating miR-21 expression which in turn down-regulates the expression of PDCD4 in gastric cancer cells;Moreover knockdown of miR-21 increased PDCD4 and PTEN expression at the protein level but not at the mRNA level;MicroRNA 21 down regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G; Expression of PDCD4 protein correlates inversely with expression of miR-21 in a number of human glioblastoma cell lines such as T98G A172 U87 and U251; Inhibition of miR-21 increases endogenous levels of PDCD4 in cell line T98G and over-expression miR-21 inhibits PDCD4-dependent apoptosis;Treatment of HSC-3 cells with Nanog- and/or Stat-3-specific small interfering RNAs effectively blocks HA-mediated Nanog-Stat-3 signaling events abrogates miR-21 production and increases PDCD4 expression;Programmed cell death 4 PDCD4 is critical in mediating apoptosis in GBM and is downregulated by miR-21 which may mediate the resistance of glioblastoma cells against chemotherapy or radiation via its target genes PDCD4; This review will focus on the roles of miRNAs family members particularly miR-21 and its target gene PDCD4 in tumors like glioblastoma and new targeting strategies as examples some new targeting therapeutic methods and molecular mechanisms of signal pathways in glioblastoma therapeutics to give the reader the current trends of approach to target regulation of these miRNA and genes for future glioma therapies;Using Western blot analysis miR-21 knockdown enhanced the expression of tumor suppressor PDCD4 and attenuated apoptosis inhibitor c-IAP2;PDCD4 and PTEN expression was decreased gradually after tumor induction and negatively correlated with miR-21 expression; Our in vivo experiments further confirmed that miR-21 plays an important role in promoting the occurrence and development of HCC by regulating PDCD4 and PTEN;METHODS 3-45-dimethylthiazol-2-yl-25-diphenyltetrazolium bromide MTT assay was used to determine the effect of 5-FU on the viability of RKO cells with knockout of miR-21 or high expression of PDCD4;The protein levels of miR-21 targets PTEN and PDCD4 were estimated; In the control experiment miR-21 mimic significantly inhibited the expression of PTEN and PDCD4 proteins in the two gastric cell lines leading to an increase in cell invasion and migration; miR-21 is overexpressed in gastric cancer and its aberrant expression may have important role in gastric cancer growth and dissemination by modulating the expression of the tumor suppressors PTEN and PDCD4 as well as by modulating the pathways involved in mediating cell growth migration invasion and apoptosis;The effects were accompanied by up-regulation of tumor suppressor PDCD4 a known miR-21 target; as well as up-regulation of cofilin and profilin two key proteins involved in actin polymerization and cytoskeleton maintenance as a consequence of miR-182 down-regulation;Increased levels of miR-21 in turn downregulate the expression of the metastasis-suppressor protein programmed cell death 4 PDCD4 a validated miR-21 target;Moreover knockdown of miR-21 increased the expressions of PDCD4 and PTEN at the protein level but not at the mRNA level;In this study we analyzed the expression of miR-21 and of its target PDCD4 Programmed Cell Death 4 during normal hematopoietic differentiation and in AMLs;MiR 21 mediates the radiation resistance of glioblastoma cells by regulating PDCD4 and hMSH2; In addition miR-21 knockdown increased the expression of endogenous PDCD4 and hMSH2 which contributed to the apoptosis and G2 arrest of T98G cells; The findings suggested that miR-21 may mediate the resistance of glioblastoma cells against radiation via its target genes PDCD4 and hMSH2;The results showed that upon exposure to mUA miR-21 expression was decreased and the expression of PTEN and Pdcd4 protein was elevated;The expression of programmed cell death-4 PDCD4 was increased by I3C and reduced by miR-21 transfection; Such enhanced chemosensitivity might be explained by the increased expression of PDCD4 which is a downstream target which miR-21 negatively regulates;It has been reported that miR-21 was upregulated in most malignant cancers the proposed mechanism of which was through suppressing expression of programmed cell death 4 PDCD4; In present study it is firstly reported that miR-21 was upregulated in Kazakh's ESCC and that miR-21 played a negative role in regulating PDCD4 using in situ hybridization ISH and luciferase reporter approach;To measure levels of microRNA miR-21 and its target gene programmed cell death 4 PDCD4 in samples of human cutaneous malignant melanoma and normal non-malignant control skin; Relative levels of miR-21 and PDCD4 mRNA were measured using a quantitative real-time reverse transcription-polymerase chain reaction; Compared with normal skin samples the relative level of miR-21 was significantly higher and the relative level of PDCD4 mRNA was significantly lower in the melanoma specimens; A significant negative correlation between PDCD4 mRNA and miR-21 was demonstrated in malignant melanoma r = -0.602; Elevated miR-21 and reduced PDCD4 mRNA levels were both significantly correlated with increased tumour size a higher Clark classification level and the presence of lymph node metastases in malignant melanoma; These findings suggest that miR-21 and PDCD4 might be potential biomarkers for malignant melanoma and might provide treatment targets in the future;MicroRNA 21 and PDCD4 expression in colorectal cancer; Studies have shown that miR-21 exerts its oncogenic activity by targeting the PDCD4 tumour suppressor 3'-UTR; The purpose of this study was to delineate the interaction between PDCD4 and its oncogenic modulator miR-21 in colorectal cancer; A cohort of 48 colorectal tumours 61 normal tissues and 7 polyps were profiled for miR-21 and PDCD4 gene expression; A significant inverse relationship between miR-21 and PDCD4 gene expression p < 0.001 was identified by RT-qPCR; In addition significant reduction of PDCD4 p < 0.001 expression and reciprocal upregulation of miR-21 p = 0.005 in a progressive manner from tumour-polyp-normal mucosae was identified; This study demonstrates the inverse relationship between miR-21 and PDCD4 thus suggesting that miR-21 post-transcriptionally modulates PDCD4 via mRNA degradation;Expression patterns of miR-21 RNA and its target tumor suppressor protein PDCD4 were mutually exclusive;Exosome shuttling microRNA 21 promotes cell migration and invasion targeting PDCD4 in esophageal cancer;Fenhexamid and fludioxonil stimulated miR-21 expression in a concentration-dependent manner and reduced the expression of miR-21 target Pdcd4 protein; Antisense to miR-21 blocked the increase in Pdcd4 protein by fenhexamid and fludioxonil;The expression of programmed cell death 4 PDCD4 which is a miR-21 targeting apoptotic gene has also been enhanced by UA; And over-expression of miR-21 in U251 cells abolished the enhancement of PDCD4 protein by UA;This process leads to microRNA-21 miR-21 production and a tumor suppressor protein e.g PDCD4 program cell death 4 reduction; Transfection of MCF-7 cells with PKCepsilon or Nanog-specific small interfering RNAs effectively blocks HA-mediated PKCepsilon-Nanog signaling events abrogates miR-21 production and increases PDCD4 expression/eIF4A binding;Through dual-luciferase method it was verified that PDCD4 and PDCD10 were real target genes of miR-21 and miR-200c respectively;miR-21 and miR-155 expression was assessed in tumor tissue and in adjacent normal tissue of 156 CRC patients by TaqMan MicroRNA assays and PDCD4 and TP53INP1 mRNA levels were measured by quantitative real-time reverse transcriptase PCR RT-PCR; Significant inverse correlations were demonstrated between miR-21 and PDCD4 mRNA and miR-155 and TP53INP1 mRNA;The aim of this study was a to determine a role of microRNA-21 in esophageal squamous cell carcinoma and b to elucidate the regulation of the programmed cell death 4 PDCD4 gene by microRNA-21; In addition the regulation of PDCD4 by microRNA-21 was elucidated to identify the mechanisms of this regulation; The PDCD4 protein levels in esophageal squamous cell carcinoma cells have an inverse correlation with microRNA-21 expression; MicroRNA-21 targets PDCD4 at the posttranscriptional level and regulates cell proliferation and invasion in esophageal squamous cell carcinoma;Maspin Pdcd4 and miR-21 expressions were evaluated by a real-time polymerase chain reaction in 20 endometrial cancer and 10 normal endometrium samples; Comparison between IA and more advanced International Federation of Gynecology and Obstetrics stages of endometrial cancer in regard to expression levels of maspin Pdcd4 and miR-21 did not reveal any significant differences;MicroRNA 21 induces 5 fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4; The proresistance effects of miR-21 were attributed to the attenuated expression of tumor suppressor genes including PTEN and PDCD4;Sequence prediction and gene expression regulation assays showed that miR-21 could reversely regulate the expression of PDCD4 P < 0.01; Suppression of miR-21 expression is associated with an elevation of Pdcd4 resulting in a significant reduction of proliferation and the apoptosis rate 2.6% was increased to 10.9%; Moreover the anti-proliferation and pro-apoptotic effect by miR-21 suppression could be reversed by PDCD4 knock down;Downregulation of Pdcd4 by mir 21 facilitates glioblastoma proliferation in vivo; We demonstrate that downregulation of mir-21 in glioblastoma-derived cell lines results in increased expression of its target programmed cell death 4 Pdcd4 a known tumor-suppressor gene; In addition our data indicate that either downregulation of mir-21 or overexpression of its target Pdcd4 in glioblastoma-derived cell lines leads to decreased proliferation increased apoptosis and decreased colony formation in soft agar; Using a glioblastoma xenograft model in immune-deficient nude mice we observe that glioblastoma-derived cell lines in which mir-21 levels are downregulated or Pdcd4 is over-expressed exhibit decreased tumor formation and growth; These critical in vivo findings demonstrate an important functional linkage between mir-21 and Pdcd4 and further elucidate the molecular mechanisms by which the known high level of mir-21 expression in glioblastoma can attribute to tumorigenesis--namely inhibition of Pdcd4 and its tumor-suppressive functions ;worse prognosis;;staging;;metastasis;;;metastasis;progression;;;;;;poor survival;;;;;metastasis;;metastasis;poor survival;drug resistance;;;;;drug resistance;;;;progression;;metastasis;metastasis;staging;;;drug resistance;staging;metastasis;differentiation;tumorigenesis;;;;drug resistance;;;;;;metastasis;;differentiation;drug resistance;;;malignant trasformation;malignant trasformation;metastasis;progression;;cell migration;;;;;;;staging;drug resistance;;tumorigenesis chronic myeloid leukemia;thyroid cancer;colon cancer;colorectal cancer;liver cancer;colon cancer;gastric cancer;liver cancer;retinoblastoma;cervical and endocervical cancer;prostate cancer;lung squamous cell cancer;prostate cancer;colorectal cancer;glioblastoma;thyroid cancer;colon cancer;ovarian cancer;ovarian cancer;kidney renal cell cancer;ovarian cancer;colorectal cancer;liver cancer;breast cancer;esophageal cancer;glioblastoma;breast cancer;lung squamous cell cancer;breast cancer;breast cancer;gastric cancer;kidney renal cell cancer;glioblastoma;colorectal cancer;colorectal cancer;colorectal cancer;lung cancer;prostate cancer;prostate cancer;gastric cancer;B cell lymphoma;glioblastoma;head and neck cancer;glioblastoma;ovarian cancer;liver cancer;colon cancer;gastric cancer;breast cancer;breast cancer;B cell lymphoma;acute myeloid leukemia;glioblastoma;prostate cancer;pancreatic cancer;esophageal cancer;melanoma;colorectal cancer;colorectal cancer;esophageal cancer;breast cancer;glioblastoma;breast cancer;breast cancer;colorectal cancer;esophageal cancer;endometrial cancer;pancreatic cancer;lung squamous cell cancer;glioblastoma hsa-miR-455-5p PDE9A 2.2582442061694 1.43472128037398e-13 -1.33415690731144 0.0115277863767632 miRanda -0.374071571591077 3.72381493991869e-06 NA NA NA hsa-miR-21-5p PDGFD 2.73773305747971 1.38864982139576e-43 -2.21895974366423 9.8844535062016e-11 miRNAWalker2_validate -0.550873661766527 3.68515951748985e-13 NA NA NA hsa-miR-320b PDGFD 1.55692969039548 1.41071034251915e-08 -2.21895974366423 9.8844535062016e-11 miRanda -0.182874490877128 0.00270207482500816 NA NA NA hsa-miR-590-3p PDGFD 2.59289455139753 1.03200520972022e-21 -2.21895974366423 9.8844535062016e-11 miRanda -0.410508831975381 7.9308556547056e-12 NA NA NA hsa-miR-590-5p PDGFD 3.18300989862077 2.06813568597893e-26 -2.21895974366423 9.8844535062016e-11 miRanda -0.358503417217371 2.33094792409083e-11 NA NA NA hsa-let-7b-5p PDGFRA 0.604314269683977 0.00140009936153214 -2.37640583073564 1.39737819859365e-09 miRNAWalker2_validate -0.521190235799922 3.3085772165913e-07 NA NA NA hsa-miR-125a-3p PDGFRA 1.24490295132072 5.26925231010328e-06 -2.37640583073564 1.39737819859365e-09 miRanda -0.147350764504837 0.0368213926583983 NA NA NA hsa-miR-129-5p PDGFRA -0.524170159980738 0.222582956006346 -2.37640583073564 1.39737819859365e-09 miRanda -0.128621152047043 0.0051316212954247 NA NA NA hsa-miR-26b-5p PDGFRA 0.885393662798425 3.2116297961629e-06 -2.37640583073564 1.39737819859365e-09 miRNAWalker2_validate -0.434540118830339 1.79640152621153e-05 NA NA NA hsa-miR-320a PDGFRA 0.438165828017084 0.0390159073347133 -2.37640583073564 1.39737819859365e-09 miRanda -0.402889384468968 1.02856691876917e-05 NA NA NA hsa-miR-320b PDGFRA 1.55692969039548 1.41071034251915e-08 -2.37640583073564 1.39737819859365e-09 miRanda -0.519602099473307 1.42131525257444e-14 NA NA NA hsa-miR-330-5p PDGFRA 1.15100069700871 4.85551805046014e-07 -2.37640583073564 1.39737819859365e-09 miRanda -0.45163495328704 5.41294182541652e-08 NA NA NA hsa-miR-339-5p PDGFRA 2.68710938429893 3.03134080808154e-16 -2.37640583073564 1.39737819859365e-09 miRanda -0.338543405646925 1.34989847950552e-09 NA NA NA hsa-miR-34a-5p PDGFRA 1.9016323452565 1.43092834643601e-14 -2.37640583073564 1.39737819859365e-09 miRNAWalker2_validate;miRTarBase -0.295453243484317 9.87541559838975e-05 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-34c-5p PDGFRA 2.07190852984647 7.35776320806257e-08 -2.37640583073564 1.39737819859365e-09 miRanda -0.225762830573297 1.74081263395182e-05 NA NA NA hsa-miR-362-3p PDGFRA 2.0756816987665 3.89026064579331e-12 -2.37640583073564 1.39737819859365e-09 miRanda -0.2120805244561 0.00115047466173652 NA NA NA hsa-miR-421 PDGFRA 1.17791565395543 6.78526676976629e-06 -2.37640583073564 1.39737819859365e-09 miRanda -0.474589953500027 4.96575533912116e-11 NA NA NA hsa-miR-429 PDGFRA 4.48815175680773 2.44117492218206e-17 -2.37640583073564 1.39737819859365e-09 miRanda -0.283783064999005 4.47719067465487e-17 NA NA NA hsa-miR-491-5p PDGFRA 0.615770352820862 0.0418295628761654 -2.37640583073564 1.39737819859365e-09 miRanda -0.259675783066868 0.000149579704439114 NA NA NA hsa-miR-590-3p PDGFRA 2.59289455139753 1.03200520972022e-21 -2.37640583073564 1.39737819859365e-09 miRanda -0.493181031896196 4.96463414718196e-13 NA NA NA hsa-miR-590-5p PDGFRA 3.18300989862077 2.06813568597893e-26 -2.37640583073564 1.39737819859365e-09 miRanda -0.507406338027508 3.77905121698734e-17 NA NA NA hsa-miR-28-5p PDGFRB 0.230152919654905 0.0742909586754846 -1.03522303801072 0.00301738788961229 miRanda -0.303906959694572 0.0253692848961482 NA NA NA hsa-miR-28-5p PDHA1 0.230152919654905 0.0742909586754846 0.0175809139222833 0.88962003132045 miRanda -0.102438455703041 0.0360258779782444 NA NA NA hsa-miR-103a-3p PDK4 1.44083190496858 1.53799939616416e-13 -4.43413379327996 1.13465040553705e-21 miRNAWalker2_validate -0.536429379917276 5.28520377706775e-06 NA NA NA hsa-miR-107 PDK4 1.30977326593435 1.30372468603965e-11 -4.43413379327996 1.13465040553705e-21 miRanda -0.435994371114923 0.0002788986136643 NA NA NA hsa-miR-142-3p PDK4 2.75247908790621 1.45636065474764e-12 -4.43413379327996 1.13465040553705e-21 miRanda -0.270015147549547 4.06953272230911e-06 NA NA NA hsa-miR-146b-5p PDK4 1.75587235896724 1.15724631266659e-07 -4.43413379327996 1.13465040553705e-21 miRanda -0.215436344585111 0.00216478985668123 NA NA NA hsa-miR-16-5p PDK4 1.75824877145857 1.68592440033108e-16 -4.43413379327996 1.13465040553705e-21 miRNAWalker2_validate -0.760601935827732 3.72544901559206e-13 NA NA NA hsa-miR-26b-5p PDK4 0.885393662798425 3.2116297961629e-06 -4.43413379327996 1.13465040553705e-21 miRNAWalker2_validate -0.659140582658327 7.99916146130379e-08 NA NA NA hsa-miR-361-5p PDK4 0.971859117235239 5.30236555707088e-09 -4.43413379327996 1.13465040553705e-21 miRanda -0.681946913755425 1.17800166691848e-06 NA NA NA hsa-miR-429 PDK4 4.48815175680773 2.44117492218206e-17 -4.43413379327996 1.13465040553705e-21 miRanda -0.233505048122357 3.07080009822309e-08 NA NA NA hsa-miR-455-5p PDK4 2.2582442061694 1.43472128037398e-13 -4.43413379327996 1.13465040553705e-21 miRanda -0.704857553173098 5.12093675730322e-23 NA NA NA hsa-miR-590-3p PDK4 2.59289455139753 1.03200520972022e-21 -4.43413379327996 1.13465040553705e-21 miRanda -0.624535327056771 5.36964650131685e-14 NA NA NA hsa-miR-484 PDLIM2 1.81844463411787 1.82951571230938e-15 -1.1220118793515 1.91456766996332e-05 miRNAWalker2_validate -0.312001561462552 5.85866821287537e-09 NA NA NA hsa-miR-28-5p PDLIM4 0.230152919654905 0.0742909586754846 -1.98288500289907 1.773551695518e-05 miRanda -0.489053947909642 0.0068216284814202 NA NA NA hsa-miR-425-5p PDZD8 3.07071373939774 4.02947460586085e-25 -0.593268526235035 0.00786340843806265 miRNAWalker2_validate -0.124891245156661 0.00027098946623417 NA NA NA hsa-miR-155-5p PEBP1 1.20164021433135 0.00086170622431261 0.0939516455530232 0.644332756868812 miRNAWalker2_validate -0.147612001737435 3.35637823415113e-08 NA NA NA hsa-miR-330-5p PEG3 1.15100069700871 4.85551805046014e-07 -3.78948650332683 1.02338376531654e-12 miRanda -0.576796246540212 3.96734265875604e-07 NA NA NA hsa-miR-491-5p PEG3 0.615770352820862 0.0418295628761654 -3.78948650332683 1.02338376531654e-12 miRanda -0.402027749727784 1.65600621779203e-05 NA NA NA hsa-miR-590-3p PEG3 2.59289455139753 1.03200520972022e-21 -3.78948650332683 1.02338376531654e-12 miRanda -0.838123324618535 5.55038037063733e-20 NA NA NA hsa-miR-21-5p PELI1 2.73773305747971 1.38864982139576e-43 -0.459617369723522 0.0185684196360042 miRNAWalker2_validate -0.110606467056369 0.0106973386731076 NA NA NA hsa-miR-28-5p PELO 0.230152919654905 0.0742909586754846 -0.197969050095806 0.163639468384103 miRanda -0.244360708798188 7.15088477486863e-06 NA NA NA hsa-miR-421 PENK 1.17791565395543 6.78526676976629e-06 -3.49877063870691 8.12499674270067e-11 miRanda -0.621808326168843 4.42368704659835e-10 NA NA NA hsa-miR-429 PENK 4.48815175680773 2.44117492218206e-17 -3.49877063870691 8.12499674270067e-11 miRanda -0.382520186710407 2.24459697541345e-16 NA NA NA hsa-miR-125a-3p PER1 1.24490295132072 5.26925231010328e-06 -2.49619827836437 1.5870539078453e-18 miRanda -0.193144804692659 0.000204202000114801 NA NA NA hsa-miR-17-5p PER1 3.2710598467455 9.93128340539455e-27 -2.49619827836437 1.5870539078453e-18 miRNAWalker2_validate -0.348801659551095 2.69972546656881e-16 NA NA NA hsa-miR-335-5p PER1 1.77247705492746 2.22457658872091e-06 -2.49619827836437 1.5870539078453e-18 miRNAWalker2_validate -0.23266099272812 3.89706922673174e-10 NA NA NA hsa-miR-484 PER1 1.81844463411787 1.82951571230938e-15 -2.49619827836437 1.5870539078453e-18 miRNAWalker2_validate -0.405277330259885 1.07592746719903e-11 NA NA NA hsa-miR-21-5p PER3 2.73773305747971 1.38864982139576e-43 -1.84077644313895 1.92358045112923e-09 miRNAWalker2_validate -0.341601475599996 6.43872496602775e-07 NA NA NA hsa-miR-28-5p PFKFB2 0.230152919654905 0.0742909586754846 0.339639560259021 0.0785231453274998 miRanda -0.203858801496991 0.00635101898716936 NA NA NA hsa-miR-28-5p PFKFB3 0.230152919654905 0.0742909586754846 -0.623033017131206 0.0296368199870525 miRanda -0.456642306384772 3.56795245588703e-05 NA NA NA hsa-miR-28-5p PGAM1 0.230152919654905 0.0742909586754846 0.145584901624757 0.397051558660682 miRanda -0.280051933740003 2.18273027635961e-05 NA NA NA hsa-miR-28-5p PGAM4 0.230152919654905 0.0742909586754846 -0.216782569774481 0.329976001166769 miRanda -0.372672257640137 1.29664080661176e-05 NA NA NA hsa-miR-21-5p PHACTR2 2.73773305747971 1.38864982139576e-43 -0.542820632041343 0.00400253640810867 miRNAWalker2_validate -0.193341150357303 3.26885564301967e-06 NA NA NA hsa-miR-28-5p PHC2 0.230152919654905 0.0742909586754846 -0.129620505752978 0.32799033683937 miRanda -0.136340878043702 0.00760433894459452 NA NA NA hsa-miR-21-5p PHF20 2.73773305747971 1.38864982139576e-43 -0.348223112629698 0.00345287006556311 miRNAWalker2_validate -0.100601080734116 0.000126530767051163 NA NA NA hsa-miR-21-5p PHIP 2.73773305747971 1.38864982139576e-43 -0.28962701207748 0.0532798598452863 miRNAWalker2_validate -0.25696858970313 1.12318542305009e-15 NA NA NA hsa-miR-15a-5p PHKB 2.34669284378787 1.69544424500258e-23 -0.783514791543888 3.9947241041821e-09 miRNAWalker2_validate -0.130758901397374 5.97277245337186e-07 NA NA NA hsa-miR-484 PHKB 1.81844463411787 1.82951571230938e-15 -0.783514791543888 3.9947241041821e-09 miRNAWalker2_validate -0.134926492127694 9.37213168284619e-07 NA NA NA hsa-miR-28-5p PI3 0.230152919654905 0.0742909586754846 2.95571010003893 0.00587537766577271 miRanda -2.41347822772441 4.17103239250978e-09 NA NA NA hsa-miR-21-5p PIK3C2A 2.73773305747971 1.38864982139576e-43 -0.593497007680329 7.84905620793731e-05 miRNAWalker2_validate -0.21591512055269 4.52247372355747e-11 NA NA NA hsa-miR-28-5p PIK3C2G 0.230152919654905 0.0742909586754846 -0.793961306261841 0.1977693293657 miRanda -0.811772401179424 0.000656557570375379 NA NA NA hsa-miR-375 PIK3IP1 1.13910305294079 0.0512283522214186 0.0421529967544005 0.870744901503072 miRNAWalker2_validate -0.112708144200559 8.85887302196387e-08 NA NA NA hsa-miR-21-5p PIK3R1 2.73773305747971 1.38864982139576e-43 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate -0.344443286817705 1.08270725892964e-10 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-425-5p PIP4K2A 3.07071373939774 4.02947460586085e-25 -0.910805543770034 1.94691784002652e-06 miRNAWalker2_validate -0.241954737010734 3.22198066544413e-17 NA NA NA hsa-miR-28-5p PITPNM3 0.230152919654905 0.0742909586754846 -1.79250302161575 2.85103802199208e-05 miRanda -0.548804611526567 0.00102463189780851 NA NA NA hsa-miR-484 PKD1 1.81844463411787 1.82951571230938e-15 -1.30762150691753 1.35470900527642e-15 miRNAWalker2_validate -0.229146668785688 1.64791369704882e-11 NA NA NA hsa-miR-21-5p PKD2 2.73773305747971 1.38864982139576e-43 -1.0649370854678 4.24438450658801e-08 miRNAWalker2_validate -0.224722849706893 2.0092912130155e-07 NA NA NA hsa-miR-155-5p PKIA 1.20164021433135 0.00086170622431261 -0.239931947493617 0.571206859758051 miRNAWalker2_validate;miRTarBase -0.424322652450059 9.74264782668145e-15 NA NA NA hsa-miR-155-5p PKN2 1.20164021433135 0.00086170622431261 -0.125971889563031 0.414793940700722 miRNAWalker2_validate;miRTarBase -0.111471465802844 3.79566738378642e-08 NA NA NA hsa-miR-21-5p PKNOX1 2.73773305747971 1.38864982139576e-43 -0.401842959429628 8.31454632301165e-05 miRNAWalker2_validate -0.147721811713243 2.61686474667443e-11 NA NA NA hsa-miR-15a-5p PLA2G2D 2.34669284378787 1.69544424500258e-23 -1.02276507955976 0.189798951526849 miRNAWalker2_validate -0.404850472000017 0.00807397819916615 NA NA NA hsa-miR-155-5p PLEKHA5 1.20164021433135 0.00086170622431261 -0.522950031208135 0.00632913279910938 miRNAWalker2_validate -0.169701515181323 1.21169302321363e-11 NA NA NA hsa-miR-330-5p PLIN1 1.15100069700871 4.85551805046014e-07 -2.6697427609327 1.11980257260822e-06 miRanda -0.28229999674749 0.0156805772169475 NA NA NA hsa-miR-590-5p PLIN1 3.18300989862077 2.06813568597893e-26 -2.6697427609327 1.11980257260822e-06 miRanda -0.464689694166197 5.73507274685274e-08 NA NA NA hsa-miR-183-5p PLOD2 4.19757025992371 4.79612296318304e-26 0.408783051727277 0.223517816964063 miRNAWalker2_validate -0.214396141295388 1.3865787925725e-08 NA NA NA hsa-miR-425-5p PLOD2 3.07071373939774 4.02947460586085e-25 0.408783051727277 0.223517816964063 miRNAWalker2_validate -0.212380601294972 3.55397374060836e-05 NA NA NA hsa-miR-155-5p PLS1 1.20164021433135 0.00086170622431261 1.41891431789693 0.000307508106046457 miRNAWalker2_validate -0.133971684219706 0.0112678946835317 NA NA NA hsa-miR-28-5p PLS3 0.230152919654905 0.0742909586754846 -0.0514153240775643 0.833811256655388 miRanda -0.297032044135022 0.00168996699891095 NA NA NA hsa-miR-15b-5p PLSCR4 1.57112623124278 9.14247846750597e-13 -2.11946408050861 2.7227459394389e-09 miRNAWalker2_validate -0.552783859166796 4.14468563510899e-13 NA NA NA hsa-miR-21-5p PM20D2 2.73773305747971 1.38864982139576e-43 -0.646198717656573 0.00795822993997918 miRNAWalker2_validate -0.245116685969271 4.96653575053893e-06 NA NA NA hsa-miR-28-5p PMPCA 0.230152919654905 0.0742909586754846 0.123149516278716 0.37712512093642 miRanda -0.165602805965652 0.00204082991524035 NA NA NA hsa-miR-28-5p PNP 0.230152919654905 0.0742909586754846 0.170631775625622 0.378531024883244 miRanda -0.467315908179538 1.96811512343973e-10 NA NA NA hsa-miR-28-5p PNPLA6 0.230152919654905 0.0742909586754846 0.178774689409943 0.166147490371253 miRanda -0.111271981070282 0.0255929996592403 NA NA NA hsa-miR-28-5p POLA1 0.230152919654905 0.0742909586754846 0.270952556065178 0.11004707053121 miRanda -0.181238243178479 0.00568173009986437 NA NA NA hsa-miR-28-5p POMP 0.230152919654905 0.0742909586754846 0.427318131942131 0.000611435464092419 miRanda -0.177971337503716 0.000219780209900492 NA NA NA hsa-miR-375 POU3F1 1.13910305294079 0.0512283522214186 -0.190136172939054 0.776823894428379 miRanda -0.210796590872722 0.000129432548694219 NA NA NA hsa-miR-21-5p PPARA 2.73773305747971 1.38864982139576e-43 -0.909556027391561 1.42525593811011e-05 miRNAWalker2_validate;miRTarBase -0.231980578824083 5.70600101394901e-07 22244963 In the final integrative analysis of lung cancer related miR-21-targets analysis 24 hub genes were identified by overlap calculation suggesting that miR-21 may play an important role in the development and progression of lung cancer through JAK/STAT signal pathway MAPK signaling pathway Wnt signaling pathway cell cycle PPAR signaling pathway apoptosis pathway and other pathways progression lung cancer hsa-miR-127-3p PPARG -0.6279281852298 0.0400829468424132 0.799726811752695 0.142490564077055 miRanda -0.27457877148018 0.00145025219502946 NA NA NA hsa-miR-130a-3p PPARG 2.02021855058359 1.26427102520415e-11 0.799726811752695 0.142490564077055 miRNAWalker2_validate;miRTarBase -0.211782344024947 0.0143830333932118 NA NA NA hsa-miR-142-3p PPARG 2.75247908790621 1.45636065474764e-12 0.799726811752695 0.142490564077055 miRanda -0.286943360595752 1.19312925340328e-05 NA NA NA hsa-miR-34c-5p PPARG 2.07190852984647 7.35776320806257e-08 0.799726811752695 0.142490564077055 miRanda -0.315547302462242 1.0309927871471e-05 NA NA NA hsa-miR-455-5p PPARG 2.2582442061694 1.43472128037398e-13 0.799726811752695 0.142490564077055 miRanda -0.292793917261273 0.000471159731781481 NA NA NA hsa-miR-484 PPM1A 1.81844463411787 1.82951571230938e-15 -0.394847284284923 0.000386558346157747 miRNAWalker2_validate -0.100919564857223 8.73686371580467e-06 NA NA NA hsa-miR-28-5p PPM1K 0.230152919654905 0.0742909586754846 -1.58286610479163 4.19807618138075e-10 miRanda -0.300192438324073 0.00272253771506583 NA NA NA hsa-miR-21-5p PPM1L 2.73773305747971 1.38864982139576e-43 -1.99556725638808 1.6810049265056e-09 miRNAWalker2_validate -0.71688703226689 4.94204896969322e-24 NA NA NA hsa-miR-129-5p PPP1R12B -0.524170159980738 0.222582956006346 -3.46376452255787 1.1364412732345e-26 miRanda -0.114902473293995 0.00375840677844166 NA NA NA hsa-miR-30b-5p PPP1R12B 0.800822374912712 0.000133601914525413 -3.46376452255787 1.1364412732345e-26 miRNAWalker2_validate -0.294710675351467 0.000214578676142783 NA NA NA hsa-miR-320a PPP1R12B 0.438165828017084 0.0390159073347133 -3.46376452255787 1.1364412732345e-26 miRanda -0.504903648090888 8.54657429836166e-11 NA NA NA hsa-miR-320b PPP1R12B 1.55692969039548 1.41071034251915e-08 -3.46376452255787 1.1364412732345e-26 miRanda -0.571357968487007 1.01434663613623e-23 NA NA NA hsa-miR-375 PPP1R12B 1.13910305294079 0.0512283522214186 -3.46376452255787 1.1364412732345e-26 miRanda -0.111916578002667 8.05662672310316e-05 NA NA NA hsa-miR-590-3p PPP1R12B 2.59289455139753 1.03200520972022e-21 -3.46376452255787 1.1364412732345e-26 miRanda -0.678654204348871 4.59689037263251e-34 NA NA NA hsa-miR-335-5p PPP1R1A 1.77247705492746 2.22457658872091e-06 -4.29451174893033 1.68849340653506e-10 miRNAWalker2_validate -0.196315958758777 0.025609138314093 NA NA NA hsa-miR-425-5p PPP2CB 3.07071373939774 4.02947460586085e-25 -0.783679156108793 2.67817932533534e-08 miRNAWalker2_validate -0.185494581813071 1.46832581012673e-18 NA NA NA hsa-miR-484 PPP2R5A 1.81844463411787 1.82951571230938e-15 -0.903448375131664 8.39328972558812e-12 miRNAWalker2_validate -0.16770839153884 8.04350521732411e-10 NA NA NA hsa-miR-28-5p PPP6C 0.230152919654905 0.0742909586754846 -0.19031980834972 0.050258767566576 miRanda -0.150745732530417 4.99325300386888e-05 NA NA NA hsa-miR-21-5p PREPL 2.73773305747971 1.38864982139576e-43 -0.488563541233025 0.000533352887750559 miRNAWalker2_validate -0.247678262012236 2.80390433537171e-16 NA NA NA hsa-miR-21-5p PRICKLE2 2.73773305747971 1.38864982139576e-43 -2.50492561876767 7.67759900282699e-16 miRNAWalker2_validate -0.32154392485735 5.80431134032331e-06 NA NA NA hsa-miR-28-5p PRIM1 0.230152919654905 0.0742909586754846 1.30978303396346 1.41496431230697e-08 miRanda -0.256241719040632 0.00483625507275263 NA NA NA hsa-miR-21-5p PRKAB2 2.73773305747971 1.38864982139576e-43 -0.313666603156149 0.0690324687741754 miRNAWalker2_validate -0.152258819913979 6.15060721100902e-05 NA NA NA hsa-miR-28-5p PRKAB2 0.230152919654905 0.0742909586754846 -0.313666603156149 0.0690324687741754 miRanda -0.133861975212892 0.0452576438977564 NA NA NA hsa-miR-28-5p PRKAR2A 0.230152919654905 0.0742909586754846 -0.958058230501873 0.00166358416501506 miRanda -0.317354369876665 0.00743076146152275 NA NA NA hsa-miR-21-5p PRKCE 2.73773305747971 1.38864982139576e-43 -0.654457944504116 0.000403726972442124 miRNAWalker2_validate -0.210629649805619 2.32442287225748e-07 NA NA NA hsa-miR-375 PRKD1 1.13910305294079 0.0512283522214186 -1.53164811371414 4.119038025094e-05 miRanda -0.141524163120329 4.45610236956069e-06 NA NA NA hsa-miR-148a-3p PRNP 1.26728238710376 2.52325607402829e-06 -0.926746483145519 0.00829639478709345 miRNAWalker2_validate -0.198421066208884 0.00154358950256845 NA NA NA hsa-miR-28-5p PROCR 0.230152919654905 0.0742909586754846 -0.206327184169522 0.485356327954563 miRanda -0.2342069971546 0.0410322925263686 NA NA NA hsa-miR-375 PROCR 1.13910305294079 0.0512283522214186 -0.206327184169522 0.485356327954563 miRNAWalker2_validate -0.126295704734695 1.57009190510441e-07 NA NA NA hsa-miR-21-5p PRPF39 2.73773305747971 1.38864982139576e-43 0.229308287295196 0.109910032278912 miRNAWalker2_validate -0.108955869704508 0.000568619475300007 NA NA NA hsa-miR-484 PRPS1 1.81844463411787 1.82951571230938e-15 -0.0430184260440516 0.7997649102077 miRNAWalker2_validate -0.112692359631711 0.00115364461088585 NA NA NA hsa-miR-92b-3p PRR5 1.20409245530001 3.41055816361655e-06 -0.030984251099837 0.866399059319718 miRNAWalker2_validate -0.129600086965992 0.000130703875447136 NA NA NA hsa-miR-196a-5p PRUNE2 1.52993069622497 0.00397268663639603 -4.80598803189319 1.66841624992026e-13 miRNAWalker2_validate -0.158445446662303 0.00937770463077229 NA NA NA hsa-miR-28-5p PSMB2 0.230152919654905 0.0742909586754846 0.792812889980063 4.40544318564962e-12 miRanda -0.151941657615569 0.000774114845147614 NA NA NA hsa-miR-15a-5p PTAR1 2.34669284378787 1.69544424500258e-23 -0.472407700260961 0.00283595748436887 miRNAWalker2_validate -0.140508129971728 5.00500725055036e-06 NA NA NA hsa-miR-21-5p PTAR1 2.73773305747971 1.38864982139576e-43 -0.472407700260961 0.00283595748436887 miRNAWalker2_validate -0.121968454647194 0.000499254155643782 NA NA NA hsa-miR-28-5p PTEN 0.230152919654905 0.0742909586754846 -0.452835975443078 0.00142504206837966 miRanda -0.112241090761127 0.0418761338534022 NA NA NA hsa-miR-21-5p PTGFR 2.73773305747971 1.38864982139576e-43 -4.31417785205749 1.80615933126723e-13 miRNAWalker2_validate -0.374729207144578 0.00515858033605477 NA NA NA hsa-miR-484 PTGS1 1.81844463411787 1.82951571230938e-15 -4.35917875057969 2.59003994200608e-15 miRNAWalker2_validate -1.23663032703239 1.50554603491686e-29 NA NA NA hsa-miR-92b-3p PTGS1 1.20409245530001 3.41055816361655e-06 -4.35917875057969 2.59003994200608e-15 miRNAWalker2_validate -0.235180743187639 0.0265260197457987 NA NA NA hsa-miR-28-5p PTP4A1 0.230152919654905 0.0742909586754846 -0.886199664882353 4.27122299209568e-05 miRanda -0.423915463155733 3.97130411096352e-07 NA NA NA hsa-miR-200b-3p PTPN12 3.78235093249346 3.18343003239465e-14 0.0767969869639664 0.640179277832713 miRNAWalker2_validate;miRTarBase -0.108410781022987 4.26654235384237e-13 NA NA NA hsa-miR-28-5p PTPN14 0.230152919654905 0.0742909586754846 -0.250947046339767 0.199025982242431 miRanda -0.182355125286094 0.0158835160785708 NA NA NA hsa-miR-28-5p PTPN21 0.230152919654905 0.0742909586754846 -1.00705050330315 2.27967729064557e-07 miRanda -0.286482648043995 0.000165409184624965 NA NA NA hsa-miR-200a-3p PTPRD 4.59434485520731 6.38952518573476e-18 -3.62979486144354 1.88740064210481e-09 miRNAWalker2_validate -0.484685907325721 2.39732201298084e-21 NA NA NA hsa-miR-200b-3p PTPRD 3.78235093249346 3.18343003239465e-14 -3.62979486144354 1.88740064210481e-09 miRNAWalker2_validate -0.496404886961795 3.59969394161722e-19 NA NA NA hsa-miR-21-5p PURA 2.73773305747971 1.38864982139576e-43 -0.587715942832882 8.7247352485337e-07 miRNAWalker2_validate -0.16429518028207 3.59975193284364e-10 NA NA NA hsa-miR-484 PYGB 1.81844463411787 1.82951571230938e-15 -1.1864973505952 3.07666105152014e-08 miRNAWalker2_validate -0.337121803417992 7.7135388286748e-15 NA NA NA hsa-miR-425-5p QKI 3.07071373939774 4.02947460586085e-25 -0.459712923996318 0.00440824124371165 miRNAWalker2_validate -0.131895394757564 7.81590643697074e-08 NA NA NA hsa-miR-21-5p RAB11FIP2 2.73773305747971 1.38864982139576e-43 -0.863768952812762 1.29857569721329e-05 miRNAWalker2_validate -0.322476169036579 6.86521182692994e-14 NA NA NA hsa-miR-28-5p RAB14 0.230152919654905 0.0742909586754846 -0.146362667657619 0.194920922540714 miRanda -0.14030739577118 0.00121789810762411 NA NA NA hsa-miR-200a-3p RAB30 4.59434485520731 6.38952518573476e-18 -1.46673818899504 1.29730263099078e-07 miRNAWalker2_validate -0.198280265299617 4.7317508873242e-17 NA NA NA hsa-miR-28-5p RAB31 0.230152919654905 0.0742909586754846 -0.565488704793941 0.0757768686383417 miRanda -0.454870285689395 0.000216129659667759 NA NA NA hsa-miR-21-5p RAB6C 2.73773305747971 1.38864982139576e-43 -0.312150276162364 0.069743541207915 miRNAWalker2_validate -0.156570291515361 3.58887993191182e-05 NA NA NA hsa-miR-15a-5p RAB9B 2.34669284378787 1.69544424500258e-23 -2.97396439533174 7.39502390026422e-13 miRNAWalker2_validate -0.638112822032233 3.22264093671024e-15 NA NA NA hsa-miR-21-5p RABGAP1 2.73773305747971 1.38864982139576e-43 -0.773246435624024 3.15867332544188e-09 miRNAWalker2_validate -0.191230046524036 2.92918757457688e-11 NA NA NA hsa-miR-375 RAC2 1.13910305294079 0.0512283522214186 0.0225400305534329 0.947191555182511 miRanda -0.111974015284125 5.98476138848745e-05 NA NA NA hsa-miR-28-5p RAD23B 0.230152919654905 0.0742909586754846 0.0950269555852143 0.477851118135714 miRanda -0.148320849148095 0.00402300883503794 NA NA NA hsa-miR-28-5p RALB 0.230152919654905 0.0742909586754846 -0.226951263019001 0.126583512825785 miRanda -0.193758468195216 0.000709351511887023 NA NA NA hsa-miR-28-5p RANBP2 0.230152919654905 0.0742909586754846 -0.627356163254904 1.3190892686946e-07 miRanda -0.134742872185232 0.00374352401460406 NA NA NA hsa-miR-28-5p RAP1A 0.230152919654905 0.0742909586754846 -1.0434884652411 1.94863584356979e-14 miRanda -0.108115499317217 0.0472190675966647 NA NA NA hsa-miR-28-5p RAP1GDS1 0.230152919654905 0.0742909586754846 -0.0374009783764384 0.781445307623292 miRanda -0.194424559370326 0.000171105703118905 NA NA NA hsa-miR-155-5p RAPGEF2 1.20164021433135 0.00086170622431261 -0.523133971893087 0.000808633238641125 miRNAWalker2_validate -0.14507831307013 1.07612712759592e-12 NA NA NA hsa-miR-21-5p RAPGEF6 2.73773305747971 1.38864982139576e-43 -0.73066954697137 0.0274012483576538 miRNAWalker2_validate -0.328036353055088 7.02827742803583e-06 NA NA NA hsa-miR-21-5p RAPH1 2.73773305747971 1.38864982139576e-43 -0.367964714644428 0.0511328736054865 miRNAWalker2_validate -0.113914782808315 0.00642714806239694 NA NA NA hsa-miR-28-5p RASGRP4 0.230152919654905 0.0742909586754846 -1.81932059503105 2.30066832429026e-06 miRanda -0.440690225574773 0.0034855563518016 NA NA NA hsa-miR-148a-3p RASSF8 1.26728238710376 2.52325607402829e-06 -1.48887021923134 4.62579164697906e-06 miRNAWalker2_validate -0.218298416380521 0.000183079975884011 NA NA NA hsa-miR-484 RBMS2 1.81844463411787 1.82951571230938e-15 -0.473519179174953 0.00699528873663777 miRNAWalker2_validate -0.26330768397635 6.34226902678525e-14 NA NA NA hsa-miR-375 RBPMS 1.13910305294079 0.0512283522214186 -1.76986611936615 2.10521492077454e-10 miRanda -0.144830861222587 3.36469930042348e-10 NA NA NA hsa-miR-484 RC3H2 1.81844463411787 1.82951571230938e-15 -0.391123326113193 0.0555596211101039 miRNAWalker2_validate -0.102018208594298 0.0151736425935674 NA NA NA hsa-miR-21-5p RDH11 2.73773305747971 1.38864982139576e-43 -0.104051876775518 0.44262357300264 miRNAWalker2_validate -0.11754219635991 7.80443248393679e-05 NA NA NA hsa-miR-28-5p RDX 0.230152919654905 0.0742909586754846 -0.333782953922244 0.221635333144355 miRanda -0.420255352708819 6.44261940698484e-05 NA NA NA hsa-miR-103a-3p RECK 1.44083190496858 1.53799939616416e-13 -2.38610578026315 7.82688892259109e-14 miRNAWalker2_validate -0.710370541819878 1.59241860145943e-20 NA NA NA hsa-miR-107 RECK 1.30977326593435 1.30372468603965e-11 -2.38610578026315 7.82688892259109e-14 miRanda -0.574665603469876 3.62440259969211e-13 NA NA NA hsa-miR-125a-3p RECK 1.24490295132072 5.26925231010328e-06 -2.38610578026315 7.82688892259109e-14 miRanda -0.16488589418631 0.00441892999318106 NA NA NA hsa-miR-15a-5p RECK 2.34669284378787 1.69544424500258e-23 -2.38610578026315 7.82688892259109e-14 miRNAWalker2_validate -0.588205505705561 1.00301566447484e-21 NA NA NA hsa-miR-15b-5p RECK 1.57112623124278 9.14247846750597e-13 -2.38610578026315 7.82688892259109e-14 miRNAWalker2_validate;miRTarBase -0.555388680562103 5.64631779038768e-16 NA NA NA hsa-miR-16-5p RECK 1.75824877145857 1.68592440033108e-16 -2.38610578026315 7.82688892259109e-14 miRNAWalker2_validate -0.590726625764408 2.73223142330884e-17 24852767 Aberrant expression level of miR-16 could suppress cell apoptosis while promote growth by regulating RECK and SOX6 which play important roles in the pathogenesis of ESCC esophageal cancer hsa-miR-182-5p RECK 3.53923166221814 5.07781258121574e-21 -2.38610578026315 7.82688892259109e-14 miRNAWalker2_validate -0.401952252290376 3.00734108680527e-26 23226455;27648365;23333633 We also identified Smad4 and RECK as potential target genes of miR-182-5p using several algorithms; In conclusion our data suggests that miR-182-5p plays an important role as an oncogene by knocking down RECK and Smad4 resulting in activation of the Wnt-beta-catenin signaling pathway in bladder cancer;In our previous results we demonstrated that miR-182 was over-expressed in breast cancer cell lines and clinical tumor tissues and its up-regulation increased tumorigenicity and invasiveness by repressing a tumor suppressor RECK;Up regulation of miR 182 by β catenin in breast cancer increases tumorigenicity and invasiveness by targeting the matrix metalloproteinase inhibitor RECK; The correlation between miR-182 and RECK was analyzed by Western blotting real-time RT-PCR and 3'-untranslated region reporter assay; Ectopic expression of miR-182 inhibited restoration of RECK protein by β-catenin inhibitor indicating miR-182 is important for β-catenin-induced down-regulation of RECK; An inverse association between miR-182 and RECK was demonstrated in breast tumor tissues; We provide evidence that miR-182 is up-regulated by β-catenin signaling pathway in breast cancer and its up-regulation increases tumorigenicity and invasiveness by repressing RECK; In addition we identify a new miR-182 target RECK which is important for miR-182-induced tumorigenesis ;;tumorigenesis bladder cancer;breast cancer;breast cancer hsa-miR-21-5p RECK 2.73773305747971 1.38864982139576e-43 -2.38610578026315 7.82688892259109e-14 miRNAWalker2_validate;miRTarBase -0.222861767216515 0.00225516786163823 19730150;20480266;22642976;18794849;25720799 Protein levels of tumor suppressor targets of the miRNAs were increased by antisense to miR-21 PTEN and RECK and miR-221 p27;Furthermore we identified that RECK reversion-inducing-cysteine-rich protein with kazal motifs a tumor suppressor gene was a direct target of miR-21; Our results suggest that miR-21 expression has a key role in regulating cellular processes in osteosarcoma likely through regulating RECK and may serve as a therapeutic target;miR 21 may acts as an oncomir by targeting RECK a matrix metalloproteinase regulator in prostate cancer; The micro RNA miRNA mir-21 has been shown to regulate invasiveness in cancer through translational repression of the Metaloproteinase MMP inhibitor RECK; Our aim is to investigate the levels of expression of RECK and miR-21 in PCa comparing with classical prognostic factors and disease outcome and also test if RECK is a target of miR-21 in in vitro study using PCa cell line; To determine if RECK is a target of miR-21 in prostate cancer we performed an in vitro assay with PCa cell line DU-145 transfected with pre-miR-21 and anti-miR-21; To determine miR-21 and RECK expression levels in PCa samples we performed quantitative real-time polymerase chain reaction qRT-PCR; From men who presented the second profile miR-21 overexpression and RECK underexpression 91.7% were staged pT3; Our results demonstrate RECK as a target of miR-21; We believe that miR-21 may be important in PCa progression through its regulation of RECK a known regulator of tumor cell invasion;Finally we showed that RECK a known tumor suppressor in gastric cancer is a bona fide target of miR-21; Taken together miR-21 may be important in the initiation and progression of gastric cancers as an oncomiR likely through regulating RECK; Our findings suggest a potential regulatory pathway in which H pylori infection upregulates expression of miR-21 which in turn downregulates RECK and then leads to the development of gastric cancer;We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase MMP inhibitors RECK and TIMP3 which are known to impact HCC progression and metastases; Finally we found that inhibition of miR-21 in murine HMGB1-overexpressing HCC xenografts led to reduced tumor MMP activity through released repression of the miR-21 targets RECK and TIMP3 which ultimately impeded tumor progression ;;staging;progression;progression;metastasis;progression pancreatic cancer;sarcoma;prostate cancer;gastric cancer;liver cancer hsa-miR-320a RECK 0.438165828017084 0.0390159073347133 -2.38610578026315 7.82688892259109e-14 miRanda -0.469827068095117 2.45224561935545e-10 NA NA NA hsa-miR-320b RECK 1.55692969039548 1.41071034251915e-08 -2.38610578026315 7.82688892259109e-14 miRanda -0.435759211025801 3.94225243911194e-15 NA NA NA hsa-miR-335-5p RECK 1.77247705492746 2.22457658872091e-06 -2.38610578026315 7.82688892259109e-14 miRNAWalker2_validate -0.209270125784107 4.90396890911045e-07 NA NA NA hsa-miR-362-3p RECK 2.0756816987665 3.89026064579331e-12 -2.38610578026315 7.82688892259109e-14 miRanda -0.165291898710768 0.00208099628860999 NA NA NA hsa-miR-421 RECK 1.17791565395543 6.78526676976629e-06 -2.38610578026315 7.82688892259109e-14 miRanda -0.22971936531287 0.000143021683587187 NA NA NA hsa-miR-429 RECK 4.48815175680773 2.44117492218206e-17 -2.38610578026315 7.82688892259109e-14 miRanda -0.330070111113333 1.19774323415797e-35 NA NA NA hsa-miR-455-5p RECK 2.2582442061694 1.43472128037398e-13 -2.38610578026315 7.82688892259109e-14 miRanda -0.108913273167651 0.0320103434590953 NA NA NA hsa-miR-590-3p RECK 2.59289455139753 1.03200520972022e-21 -2.38610578026315 7.82688892259109e-14 miRanda -0.401357739756377 9.00140040524923e-13 27757042 miR 590 5p regulates gastric cancer cell growth and chemosensitivity through RECK and the AKT/ERK pathway gastric cancer hsa-miR-590-5p RECK 3.18300989862077 2.06813568597893e-26 -2.38610578026315 7.82688892259109e-14 miRanda -0.426230019805762 6.97877235043399e-18 27757042 miR 590 5p regulates gastric cancer cell growth and chemosensitivity through RECK and the AKT/ERK pathway; RECK was identified as a direct target of miR-590-5p; Furthermore reintroduction of RECK inhibited the oncogenic effects of miR-590-5p by suppressing cell proliferation and invasion and increasing drug sensitivity gastric cancer hsa-miR-107 RELN 1.30977326593435 1.30372468603965e-11 -4.70097153618157 2.41994737445055e-14 miRanda -0.864531155871559 2.37615647567707e-08 NA NA NA hsa-miR-10a-5p RELN 1.15016989191194 0.00372037233992369 -4.70097153618157 2.41994737445055e-14 miRNAWalker2_validate -0.434923604199382 1.19694323754989e-08 NA NA NA hsa-miR-128-3p RELN 1.63756041666078 6.79626586407187e-14 -4.70097153618157 2.41994737445055e-14 miRNAWalker2_validate;miRTarBase -0.992675879127048 1.26551313786224e-13 NA NA NA hsa-miR-361-5p RELN 0.971859117235239 5.30236555707088e-09 -4.70097153618157 2.41994737445055e-14 miRanda -0.985124584543506 6.73805550100544e-08 NA NA NA hsa-miR-421 RELN 1.17791565395543 6.78526676976629e-06 -4.70097153618157 2.41994737445055e-14 miRanda -0.438611973049058 0.000174869104938267 NA NA NA hsa-miR-429 RELN 4.48815175680773 2.44117492218206e-17 -4.70097153618157 2.41994737445055e-14 miRanda -0.46299684688601 5.9766012292285e-18 NA NA NA hsa-miR-590-3p RELN 2.59289455139753 1.03200520972022e-21 -4.70097153618157 2.41994737445055e-14 miRanda -0.679484434038679 5.37290190631669e-10 NA NA NA hsa-miR-28-5p RELT 0.230152919654905 0.0742909586754846 0.700795342289864 0.000935731898783111 miRanda -0.29683956415767 0.000298861775848362 NA NA NA hsa-miR-28-5p REPS1 0.230152919654905 0.0742909586754846 -0.15619668866394 0.170231059358007 miRanda -0.144836818646168 0.000930273884392345 NA NA NA hsa-miR-92b-3p RERE 1.20409245530001 3.41055816361655e-06 -0.627009428806385 9.027742861077e-05 miRNAWalker2_validate -0.112492422716355 0.000152747934110892 NA NA NA hsa-miR-21-5p REST 2.73773305747971 1.38864982139576e-43 -0.509917606171453 0.126822367219067 miRNAWalker2_validate;miRTarBase -0.23111046979349 0.00177911076194298 NA NA NA hsa-miR-21-5p REV1 2.73773305747971 1.38864982139576e-43 -0.393249470063309 0.00214150723661556 miRNAWalker2_validate -0.10050962014992 0.000384144202304668 NA NA NA hsa-miR-183-5p REV3L 4.19757025992371 4.79612296318304e-26 -1.48371551738225 3.11717527702179e-13 miRNAWalker2_validate -0.155286998491104 3.26728480880433e-11 NA NA NA hsa-miR-21-5p REV3L 2.73773305747971 1.38864982139576e-43 -1.48371551738225 3.11717527702179e-13 miRNAWalker2_validate -0.364798100378537 4.3070027953459e-16 NA NA NA hsa-miR-28-5p REXO2 0.230152919654905 0.0742909586754846 -0.143942897906939 0.359951830502903 miRanda -0.138617756260575 0.0225364867826611 NA NA NA hsa-miR-484 RFTN1 1.81844463411787 1.82951571230938e-15 -0.515091372232221 0.0525029974344917 miRNAWalker2_validate -0.257379628480307 1.99953616604559e-06 NA NA NA hsa-miR-484 RGP1 1.81844463411787 1.82951571230938e-15 -0.559845500700471 0.0212137137112516 miRNAWalker2_validate -0.14644068642107 0.00338167758616466 NA NA NA hsa-miR-15a-5p RGPD5 2.34669284378787 1.69544424500258e-23 -1.03214798702375 0.0159209450717177 miRNAWalker2_validate -0.197570776945546 0.0188637378314638 NA NA NA hsa-miR-361-5p RGS2 0.971859117235239 5.30236555707088e-09 -3.25680856778858 2.40581826148964e-17 miRanda -1.24234689701743 1.39482736474351e-30 NA NA NA hsa-miR-590-3p RGS2 2.59289455139753 1.03200520972022e-21 -3.25680856778858 2.40581826148964e-17 miRanda -0.601958759507975 3.01518611983769e-19 NA NA NA hsa-miR-21-5p RHOB 2.73773305747971 1.38864982139576e-43 -2.20287028501037 2.22821817082748e-20 miRNAWalker2_validate;miRTarBase -0.405993059696751 4.47194852880169e-14 21872591;25861727 miR 21 targets the tumor suppressor RhoB and regulates proliferation invasion and apoptosis in colorectal cancer cells; Here we show that expression of miR-21 in HEK293 and several colorectal cancer cells was found inversely correlated with ras homolog gene family member B RhoB expression; miR-21 expression significantly suppressed RhoB 3' UTR luciferase-reporter activity but the inhibitory effect was lost when the putative target sites were mutated; Exogenous miR-21 over-expression mimicked the effect of RhoB knockdown in promoting proliferation and invasion and inhibiting apoptosis whereas anti-miR-21 or RhoB expression yielded opposite effects in colorectal cancer cells; These results suggest that miR-21 is a regulator of RhoB expression and RhoB could be a useful target in exploring the potential therapeutic benefits of miR-21 mediated tumor cell behaviors in colorectal cancer;Here we demonstrate that intravenously-administered chlorotoxin CTX-coupled targeted stable nucleic acid lipid particle SNALP-formulated anti-miR-21 oligonucleotides accumulate preferentially within brain tumors and promote efficient miR-21 silencing which results in increased mRNA and protein levels of its target RhoB while showing no signs of systemic immunogenicity ; colorectal cancer;glioblastoma hsa-miR-21-5p RHOQ 2.73773305747971 1.38864982139576e-43 -0.721783816433531 8.67761229992978e-06 miRNAWalker2_validate -0.230476845513809 8.81244860583352e-11 NA NA NA hsa-miR-28-5p RIMS2 0.230152919654905 0.0742909586754846 -2.03271632474241 0.00172161214577439 miRanda -0.730694991790289 0.00378301484589485 NA NA NA hsa-miR-28-5p RIMS3 0.230152919654905 0.0742909586754846 -1.42027619315578 3.00440701262036e-05 miRanda -0.371195016214119 0.0052533129807201 NA NA NA hsa-miR-200a-3p RIN2 4.59434485520731 6.38952518573476e-18 0.108109453171399 0.623647304950009 miRNAWalker2_validate -0.133262714787497 8.38095298904146e-13 NA NA NA hsa-miR-200b-3p RIN2 3.78235093249346 3.18343003239465e-14 0.108109453171399 0.623647304950009 miRNAWalker2_validate -0.14486033086184 5.69823401550372e-13 NA NA NA hsa-miR-28-5p RIN3 0.230152919654905 0.0742909586754846 -0.542708773196135 0.0113680652033468 miRanda -0.219800771034953 0.00823513923694552 NA NA NA hsa-miR-21-5p RMND5A 2.73773305747971 1.38864982139576e-43 -0.0451102302251245 0.744011177402599 miRNAWalker2_validate -0.163888293503066 5.06540253627307e-08 NA NA NA hsa-miR-28-5p RNASE2 0.230152919654905 0.0742909586754846 0.974974484894896 0.0418044824902804 miRanda -0.430514139428407 0.0206748907239184 NA NA NA hsa-miR-200b-3p RND3 3.78235093249346 3.18343003239465e-14 -1.48017982993852 1.2895596822753e-07 miRNAWalker2_validate;miRTarBase -0.19913170053455 1.49420747554704e-14 26935796 MicroRNA 200b inhibits epithelial mesenchymal transition and migration of cervical cancer cells by directly targeting RhoE cervical and endocervical cancer hsa-miR-21-5p RNF11 2.73773305747971 1.38864982139576e-43 -0.727166215398439 2.6185022638599e-08 miRNAWalker2_validate -0.150994844144707 1.92425724082936e-07 NA NA NA hsa-miR-484 RNF11 1.81844463411787 1.82951571230938e-15 -0.727166215398439 2.6185022638599e-08 miRNAWalker2_validate -0.121954037398567 6.23801722398358e-06 NA NA NA hsa-miR-484 RNF115 1.81844463411787 1.82951571230938e-15 -0.493974122722622 0.0005440404885441 miRNAWalker2_validate -0.148453226806677 3.39443032808161e-07 NA NA NA hsa-miR-155-5p RNF123 1.20164021433135 0.00086170622431261 0.124381308002804 0.293510725696328 miRTarBase -0.103546828496007 1.57431131676649e-11 NA NA NA hsa-miR-28-5p RNF138 0.230152919654905 0.0742909586754846 -0.156719080507766 0.325879691930667 miRanda -0.232103480013149 0.000153907588573085 NA NA NA hsa-miR-28-5p RNF187 0.230152919654905 0.0742909586754846 0.391793342999819 0.000798028867028987 miRanda -0.124732972157798 0.00582356408498892 NA NA NA hsa-miR-28-5p RNF19B 0.230152919654905 0.0742909586754846 -0.366392768108229 0.0674163967705597 miRanda -0.373082589803971 1.18950369767685e-06 NA NA NA hsa-miR-28-5p RNF20 0.230152919654905 0.0742909586754846 -0.463561310696717 0.000221260745993015 miRanda -0.164644314774997 0.000703524326617246 NA NA NA hsa-miR-28-5p RPL23AP82 0.230152919654905 0.0742909586754846 -0.427166979495454 0.00421215081367884 miRanda -0.136612370246241 0.0183043088209289 NA NA NA hsa-miR-92b-3p RPL3 1.20409245530001 3.41055816361655e-06 -0.605716597113874 0.000196663525050005 miRNAWalker2_validate -0.208064852817548 1.87621649360115e-12 NA NA NA hsa-miR-28-5p RPL7L1 0.230152919654905 0.0742909586754846 0.169091887622107 0.186217333948955 miRanda -0.119020399422093 0.0158814807333916 NA NA NA hsa-miR-155-5p RPRD1A 1.20164021433135 0.00086170622431261 -0.455803486721977 0.00415346132283456 miRNAWalker2_validate -0.124698589468348 2.4099077500684e-09 NA NA NA hsa-miR-92b-3p RPS14 1.20409245530001 3.41055816361655e-06 -0.308514683686125 0.0640252949846099 miRNAWalker2_validate -0.145241555611643 1.98518727648989e-06 NA NA NA hsa-miR-484 RPS27L 1.81844463411787 1.82951571230938e-15 -0.261293273346445 0.110603094363519 miRNAWalker2_validate -0.128895948369535 0.000115900671045491 NA NA NA hsa-miR-92b-3p RPS28 1.20409245530001 3.41055816361655e-06 -0.154199961165242 0.833002802387861 miRNAWalker2_validate -0.27917471939307 0.0396620333178774 NA NA NA hsa-miR-92b-3p RPS3A 1.20409245530001 3.41055816361655e-06 -0.723466933805319 4.59981717322799e-06 miRNAWalker2_validate -0.114256715861068 0.000100194992836683 NA NA NA hsa-miR-92b-3p RPS4X 1.20409245530001 3.41055816361655e-06 -0.443226128645405 0.003540587376511 miRNAWalker2_validate -0.128418673824602 4.3615792059737e-06 NA NA NA hsa-miR-21-5p RPS6KA3 2.73773305747971 1.38864982139576e-43 -0.370806818018999 0.0220707753218686 miRNAWalker2_validate -0.115651579127679 0.00124546897217506 NA NA NA hsa-miR-148a-3p RPS6KA5 1.26728238710376 2.52325607402829e-06 -1.70962855889487 4.52042697209154e-09 miRNAWalker2_validate;miRTarBase -0.140257061314002 0.00809054476069603 20406806 MiR 148a attenuates paclitaxel resistance of hormone refractory drug resistant prostate cancer PC3 cells by regulating MSK1 expression; Computer-aided algorithms predicted mitogen- and stress-activated protein kinase MSK1 as a potential target of miR-148a; Indeed miR-148a overexpression decreased expression of MSK1; Using luciferase reporter assays we identified MSK1 as a direct target of miR-148a; MiR-148a reduced MSK1 expression by directly targeting its 3'-UTR in PC3PR cells; Furthermore MSK1 knockdown reduced paclitaxel-resistance of PC3PR cells indicating that miR-148a attenuates paclitaxel-resistance of hormone-refractory drug-resistant PC3PR cells in part by regulating MSK1 expression drug resistance prostate cancer hsa-miR-28-5p RPS6KA5 0.230152919654905 0.0742909586754846 -1.70962855889487 4.52042697209154e-09 miRanda -0.315380639309258 0.00612212557450078 NA NA NA hsa-miR-28-5p RPTN 0.230152919654905 0.0742909586754846 0.0555787561287291 0.935153859147513 miRanda -1.28198986296554 9.79108281818831e-07 NA NA NA hsa-miR-484 RRAGD 1.81844463411787 1.82951571230938e-15 -1.28210533175691 5.97051882858326e-05 miRNAWalker2_validate -0.327552469220649 5.73573393557174e-07 NA NA NA hsa-miR-28-5p RRM1 0.230152919654905 0.0742909586754846 0.204766272897759 0.267206839773836 miRanda -0.373451579223468 1.15366289107971e-07 NA NA NA hsa-miR-375 RRN3P2 1.13910305294079 0.0512283522214186 -1.08987085013697 0.000790302641723623 miRanda -0.121885359836982 5.09647341323916e-06 NA NA NA hsa-miR-21-5p RSF1 2.73773305747971 1.38864982139576e-43 -0.424315702706687 0.00580455427992916 miRNAWalker2_validate -0.191528203612763 1.2135033596362e-08 NA NA NA hsa-miR-21-5p RSPRY1 2.73773305747971 1.38864982139576e-43 -0.396470691331583 0.0647584715236045 miRNAWalker2_validate -0.133483317102797 0.00501142291243352 NA NA NA hsa-miR-21-5p RUFY3 2.73773305747971 1.38864982139576e-43 -0.325883312386743 0.0105968173799186 miRNAWalker2_validate -0.134402135223 1.52359191662593e-06 NA NA NA hsa-let-7e-5p RUNX1T1 0.860104282510173 6.04758298373779e-05 -3.29112409449622 2.69681218718585e-11 miRNAWalker2_validate -0.404119087707336 0.000392157928460568 NA NA NA hsa-miR-103a-3p RUNX1T1 1.44083190496858 1.53799939616416e-13 -3.29112409449622 2.69681218718585e-11 miRNAWalker2_validate -1.21229003255058 1.60524480346665e-25 NA NA NA hsa-miR-106b-5p RUNX1T1 2.46782146831112 1.36171495805632e-23 -3.29112409449622 2.69681218718585e-11 miRNAWalker2_validate -0.928044856609184 1.951617036923e-25 NA NA NA hsa-miR-107 RUNX1T1 1.30977326593435 1.30372468603965e-11 -3.29112409449622 2.69681218718585e-11 miRanda -0.865770428494938 1.13960851967701e-12 NA NA NA hsa-miR-125a-3p RUNX1T1 1.24490295132072 5.26925231010328e-06 -3.29112409449622 2.69681218718585e-11 miRanda -0.242506863179942 0.00649700970286752 NA NA NA hsa-miR-16-5p RUNX1T1 1.75824877145857 1.68592440033108e-16 -3.29112409449622 2.69681218718585e-11 miRNAWalker2_validate -1.13538729640048 1.89702330650412e-27 NA NA NA hsa-miR-324-5p RUNX1T1 2.95683728155095 1.32960514360912e-20 -3.29112409449622 2.69681218718585e-11 miRanda -0.613404783631241 4.12697034100142e-18 NA NA NA hsa-miR-342-3p RUNX1T1 1.49115144672245 1.43879249744621e-07 -3.29112409449622 2.69681218718585e-11 miRanda -0.25848322559926 0.0024554140847599 NA NA NA hsa-miR-361-5p RUNX1T1 0.971859117235239 5.30236555707088e-09 -3.29112409449622 2.69681218718585e-11 miRanda -1.17651151290599 1.04449203252622e-16 NA NA NA hsa-miR-421 RUNX1T1 1.17791565395543 6.78526676976629e-06 -3.29112409449622 2.69681218718585e-11 miRanda -0.403539549497737 1.32445301794781e-05 NA NA NA hsa-miR-484 RUNX2 1.81844463411787 1.82951571230938e-15 1.10864083351526 0.00100348774671037 miRNAWalker2_validate -0.148952769950852 0.0327190244249141 NA NA NA hsa-miR-375 RYR2 1.13910305294079 0.0512283522214186 -3.05265921395896 1.45778696980797e-09 miRanda -0.144530904192722 0.000652852467297639 NA NA NA hsa-miR-590-3p S100B 2.59289455139753 1.03200520972022e-21 -2.20142886868178 5.65710476507264e-06 miRanda -0.294297288499904 0.000584418017198342 NA NA NA hsa-miR-28-5p S100PBP 0.230152919654905 0.0742909586754846 0.260443246046253 0.0144245621822752 miRanda -0.126949586398621 0.00195075007135234 NA NA NA hsa-miR-21-5p SACM1L 2.73773305747971 1.38864982139576e-43 -0.203371006178379 0.107791967558549 miRNAWalker2_validate -0.17937400540074 5.29621613372744e-11 NA NA NA hsa-miR-375 SAMD4A 1.13910305294079 0.0512283522214186 -2.17607774370782 7.9670339471712e-12 miRNAWalker2_validate;miRanda -0.161877269255431 9.69050324424653e-10 NA NA NA hsa-miR-21-5p SAMD5 2.73773305747971 1.38864982139576e-43 -1.64315336109936 0.000131677341092201 miRNAWalker2_validate -0.377704277551928 7.73420439355617e-05 NA NA NA hsa-miR-28-5p SAMD9 0.230152919654905 0.0742909586754846 0.412236068771672 0.317106292831732 miRanda -0.699329788911255 1.01204871528151e-05 NA NA NA hsa-miR-375 SAMSN1 1.13910305294079 0.0512283522214186 -1.25329983628171 0.00422387138761965 miRanda -0.113601152493741 0.00171723315680055 NA NA NA hsa-miR-21-5p SASH1 2.73773305747971 1.38864982139576e-43 -1.1614186593618 6.05091565532784e-07 miRNAWalker2_validate -0.343285025567431 1.8763199619874e-11 NA NA NA hsa-miR-484 SAV1 1.81844463411787 1.82951571230938e-15 -0.303251103809696 0.0442199438642061 miRNAWalker2_validate -0.144889834603117 2.27277157560636e-06 NA NA NA hsa-miR-196a-5p SCN11A 1.52993069622497 0.00397268663639603 -3.60660741530833 1.36502570238554e-10 miRNAWalker2_validate -0.20820838128812 5.97630306736033e-05 NA NA NA hsa-miR-320b SCN3A 1.55692969039548 1.41071034251915e-08 -2.32699009748223 7.40591172107087e-07 miRanda -0.287579373437397 0.00049643252312399 NA NA NA hsa-miR-335-5p SCN3A 1.77247705492746 2.22457658872091e-06 -2.32699009748223 7.40591172107087e-07 miRNAWalker2_validate -0.144077495786066 0.0179414198521573 NA NA NA hsa-miR-429 SCN3A 4.48815175680773 2.44117492218206e-17 -2.32699009748223 7.40591172107087e-07 miRanda -0.192760167367505 3.13492480043458e-06 NA NA NA hsa-miR-590-3p SCN3A 2.59289455139753 1.03200520972022e-21 -2.32699009748223 7.40591172107087e-07 miRanda -0.338719090447187 4.38360017414856e-05 NA NA NA hsa-miR-590-5p SCN3A 3.18300989862077 2.06813568597893e-26 -2.32699009748223 7.40591172107087e-07 miRanda -0.390266740977514 1.09444741377938e-07 NA NA NA hsa-miR-28-5p SDCCAG8 0.230152919654905 0.0742909586754846 -0.20112880099445 0.0879690027615822 miRanda -0.163840183450215 0.000295630318405037 NA NA NA hsa-miR-21-5p SEC63 2.73773305747971 1.38864982139576e-43 -0.392158481712129 0.000187391519886184 miRNAWalker2_validate -0.108009564310946 2.85025635537157e-06 NA NA NA hsa-miR-148a-3p SECISBP2L 1.26728238710376 2.52325607402829e-06 -0.854795751139402 1.23475114634629e-06 miRNAWalker2_validate -0.132164770139205 2.81795578870065e-05 NA NA NA hsa-miR-21-5p SEMA5A 2.73773305747971 1.38864982139576e-43 -0.337261155265871 0.498715072232607 miRNAWalker2_validate -0.380083818737506 0.000561519938915859 NA NA NA hsa-miR-28-5p SENP3 0.230152919654905 0.0742909586754846 0.182932620797705 0.131962535977428 miRanda -0.142278866405201 0.00233512220486855 NA NA NA hsa-miR-15b-5p SEPT2 1.57112623124278 9.14247846750597e-13 -0.407500932881964 0.00043210583412743 miRNAWalker2_validate -0.123443212447296 5.72843575284938e-07 NA NA NA hsa-miR-28-5p SEPT6 0.230152919654905 0.0742909586754846 -0.864389874757516 0.000699734406348827 miRanda -0.307187602766057 0.00194415404601489 NA NA NA hsa-miR-21-5p SERAC1 2.73773305747971 1.38864982139576e-43 -0.0250471243239589 0.86083306049364 miRNAWalker2_validate -0.107845298409294 0.000604119272813588 NA NA NA hsa-miR-28-5p SERPINA1 0.230152919654905 0.0742909586754846 1.52344630368073 0.00809464089833033 miRanda -0.820748940700258 0.000229583617188887 NA NA NA hsa-miR-28-5p SERPINB8 0.230152919654905 0.0742909586754846 -0.55445236751157 0.017511794013207 miRanda -0.389051448152132 1.50947361297363e-05 NA NA NA hsa-miR-21-5p SERPINI1 2.73773305747971 1.38864982139576e-43 -0.55479763518509 0.0596211407016171 miRNAWalker2_validate -0.197051809083528 0.00254049459068754 22464652 MicroRNA 21 inhibits Serpini1 a gene with novel tumour suppressive effects in gastric cancer; Molecular techniques include microRNA microarrays cDNA microarrays qRT-PCR for miR and mRNA expression transfection of MKN28 with miR-21 inhibitor or Serpini1 followed by Western blotting cell cycle analysis by flow cytometry and luciferase reporter assay; This search identified Serpini1 as a putative miR-21 target; Luciferase assays demonstrated direct interaction between miR-21 and Serpini1 3'UTR miR-21 and Serpini1 expression levels were inversely correlated in a subgroup of gastric cancers suggesting a regulatory mechanism that included both of these molecules; Taken together these data suggest that in a subgroup of gastric cancers miR-21 is upregulated inducing downregulation of Serpini1 which in turn releases the G1-S transition checkpoint with the end result being increased tumour growth gastric cancer hsa-miR-21-5p SESN1 2.73773305747971 1.38864982139576e-43 -0.493278465606398 0.00887442896202912 miRNAWalker2_validate -0.206141304526145 6.43975390937491e-07 NA NA NA hsa-miR-148a-3p SESTD1 1.26728238710376 2.52325607402829e-06 -0.825183103866571 0.000206449232750826 miRNAWalker2_validate -0.121406173925669 0.00229988519360098 NA NA NA hsa-miR-21-5p SESTD1 2.73773305747971 1.38864982139576e-43 -0.825183103866571 0.000206449232750826 miRNAWalker2_validate -0.245933700780767 5.41472056737539e-07 NA NA NA hsa-miR-28-5p SETBP1 0.230152919654905 0.0742909586754846 -2.26227903514797 8.87237114441678e-09 miRanda -0.637608961674681 3.59789314297728e-05 NA NA NA hsa-miR-28-5p SETD3 0.230152919654905 0.0742909586754846 -0.540709000480151 6.78781937310879e-07 miRanda -0.149361237614274 0.000416369625779806 NA NA NA hsa-miR-484 SETD7 1.81844463411787 1.82951571230938e-15 -1.13463057726458 1.78342966519954e-10 miRNAWalker2_validate -0.287688611829222 1.66267321246052e-15 NA NA NA hsa-miR-28-5p SF1 0.230152919654905 0.0742909586754846 -0.348007840685543 2.64192237924634e-06 miRanda -0.106726239319163 0.000179029260100381 NA NA NA hsa-miR-335-5p SFRP1 1.77247705492746 2.22457658872091e-06 -4.72165743596444 1.94213340952985e-11 miRNAWalker2_validate -0.223983466322638 0.015151960415105 NA NA NA hsa-miR-375 SFRP4 1.13910305294079 0.0512283522214186 -1.41812614850623 0.144139876921528 miRanda -0.337279266167069 2.30235054354617e-05 NA NA NA hsa-miR-28-5p SFXN1 0.230152919654905 0.0742909586754846 0.818901148918101 3.85193726545464e-09 miRanda -0.150949754625464 0.00576878285021397 NA NA NA hsa-miR-21-5p SGCB 2.73773305747971 1.38864982139576e-43 -1.44760592804974 4.88730706418823e-10 miRNAWalker2_validate -0.18365578287039 0.000469206423117598 NA NA NA hsa-miR-155-5p SGPL1 1.20164021433135 0.00086170622431261 0.907724512280796 1.84518302027796e-05 miRNAWalker2_validate -0.127400987609108 6.81176293070489e-06 NA NA NA hsa-miR-375 SH3BGRL 1.13910305294079 0.0512283522214186 -1.43100123895073 2.53257963935967e-09 miRanda -0.112698132884157 1.48235123725302e-08 NA NA NA hsa-miR-183-5p SH3D19 4.19757025992371 4.79612296318304e-26 -1.30425154826739 1.64955066860169e-11 miRNAWalker2_validate -0.150955579710479 9.1222773951251e-12 NA NA NA hsa-miR-28-5p SHB 0.230152919654905 0.0742909586754846 -0.408306120192271 0.0420540555811169 miRanda -0.258933440250211 0.000848265367520823 NA NA NA hsa-miR-28-5p SIGLEC1 0.230152919654905 0.0742909586754846 -0.883561500953726 0.0567098450341222 miRanda -0.543216806571084 0.00249625184266928 NA NA NA hsa-miR-28-5p SIK2 0.230152919654905 0.0742909586754846 -0.895905910195029 1.03810013473188e-10 miRanda -0.220611758234709 5.13038085024047e-05 NA NA NA hsa-miR-484 SIPA1L2 1.81844463411787 1.82951571230938e-15 -0.971413252489691 0.000894981637447019 miRNAWalker2_validate -0.180778449760465 0.00274485154046324 NA NA NA hsa-miR-28-5p SIRPB1 0.230152919654905 0.0742909586754846 -0.268450074973082 0.505804620124607 miRanda -0.409679788618232 0.00872413140456204 NA NA NA hsa-miR-15a-5p SKAP2 2.34669284378787 1.69544424500258e-23 -0.546982758118275 0.000983483350554369 miRNAWalker2_validate -0.105790370910596 0.00114561794651546 NA NA NA hsa-miR-484 SKAP2 1.81844463411787 1.82951571230938e-15 -0.546982758118275 0.000983483350554369 miRNAWalker2_validate -0.141624287539243 3.13088706156572e-05 NA NA NA hsa-miR-484 SKI 1.81844463411787 1.82951571230938e-15 -0.521901971037482 2.06532307493616e-05 miRNAWalker2_validate -0.152448669681895 8.67390192315694e-10 NA NA NA hsa-miR-21-5p SLAIN2 2.73773305747971 1.38864982139576e-43 -0.73731888558646 4.93543388012554e-10 miRNAWalker2_validate -0.168053060236078 1.36987921335411e-10 NA NA NA hsa-miR-28-5p SLC13A5 0.230152919654905 0.0742909586754846 1.06053188626373 0.058626601945695 miRanda -0.717897798977016 0.000942817177570042 NA NA NA hsa-miR-92b-3p SLC15A1 1.20409245530001 3.41055816361655e-06 2.68757294733734 3.21267211460293e-05 miRNAWalker2_validate;miRTarBase -0.28177667596656 0.0199504556636962 NA NA NA hsa-miR-484 SLC16A1 1.81844463411787 1.82951571230938e-15 -0.210854993305295 0.683152915273117 miRNAWalker2_validate -0.370545936613824 0.000461820957802738 NA NA NA hsa-miR-28-5p SLC24A3 0.230152919654905 0.0742909586754846 -3.09472150595164 1.75812095855535e-11 miRanda -0.382080443404139 0.0370223776088667 NA NA NA hsa-miR-28-5p SLC25A32 0.230152919654905 0.0742909586754846 -0.251073181478352 0.0792172361210918 miRanda -0.141182071131497 0.0106343182377996 NA NA NA hsa-miR-92b-3p SLC25A4 1.20409245530001 3.41055816361655e-06 -1.33644619640139 4.13992398920302e-12 miRNAWalker2_validate -0.131574271992218 0.000315336327437302 NA NA NA hsa-miR-28-5p SLC25A45 0.230152919654905 0.0742909586754846 -0.45199180014675 0.0484262874283961 miRanda -0.322764140692069 0.000261510699586493 NA NA NA hsa-miR-21-5p SLC26A2 2.73773305747971 1.38864982139576e-43 -0.367504571376556 0.137113607276024 miRNAWalker2_validate -0.170684490431541 0.00180733352301297 NA NA NA hsa-miR-28-5p SLC2A1 0.230152919654905 0.0742909586754846 0.844343559552885 0.0169954869776823 miRanda -0.344842594294832 0.012090538285836 NA NA NA hsa-miR-28-5p SLC2A12 0.230152919654905 0.0742909586754846 -1.15438007906874 0.000179104186808115 miRanda -0.357721102256611 0.00288675177715971 NA NA NA hsa-miR-183-5p SLC2A3 4.19757025992371 4.79612296318304e-26 -2.09454232135098 3.92772896271437e-08 miRNAWalker2_validate -0.355704538390108 7.9272927384974e-17 NA NA NA hsa-miR-28-5p SLC31A1 0.230152919654905 0.0742909586754846 0.309713524716562 0.0487501496092828 miRanda -0.125193545609399 0.0397382185828438 NA NA NA hsa-miR-28-5p SLC35B4 0.230152919654905 0.0742909586754846 -0.0558520609113842 0.697638933075465 miRanda -0.122604236475589 0.0271836770323795 NA NA NA hsa-miR-15b-5p SLC39A14 1.57112623124278 9.14247846750597e-13 -0.740419591746377 0.00495509756841203 miRNAWalker2_validate -0.336518171598678 1.83004849278751e-09 NA NA NA hsa-miR-28-5p SLC39A14 0.230152919654905 0.0742909586754846 -0.740419591746377 0.00495509756841203 miRanda -0.368031990548765 0.000309430743556287 NA NA NA hsa-miR-484 SLC43A1 1.81844463411787 1.82951571230938e-15 -1.4944308564938 7.22603502597254e-06 miRNAWalker2_validate -0.310387248416027 6.16937817807174e-06 NA NA NA hsa-miR-28-5p SLCO3A1 0.230152919654905 0.0742909586754846 -0.349114583112527 0.300053914964445 miRanda -0.454740510293 0.000470527991083849 NA NA NA hsa-miR-28-5p SLCO4A1 0.230152919654905 0.0742909586754846 -1.23841446896867 0.026128285855618 miRanda -0.634066881980593 0.00332639250176539 NA NA NA hsa-miR-125a-3p SLIT3 1.24490295132072 5.26925231010328e-06 -3.59991978393086 7.98217561727376e-15 miRanda -0.267946549477597 0.00146682978197192 NA NA NA hsa-miR-326 SLIT3 0.715313016136042 0.0610265683213359 -3.59991978393086 7.98217561727376e-15 miRanda -0.155025258288663 0.0110940198002743 NA NA NA hsa-miR-330-5p SLIT3 1.15100069700871 4.85551805046014e-07 -3.59991978393086 7.98217561727376e-15 miRanda -0.444499555127356 8.86704054964126e-06 NA NA NA hsa-miR-362-3p SLIT3 2.0756816987665 3.89026064579331e-12 -3.59991978393086 7.98217561727376e-15 miRanda -0.525827926592761 6.08893179969567e-12 NA NA NA hsa-miR-590-3p SLIT3 2.59289455139753 1.03200520972022e-21 -3.59991978393086 7.98217561727376e-15 miRanda -0.818506602424457 4.92649889490357e-25 NA NA NA hsa-miR-590-5p SLIT3 3.18300989862077 2.06813568597893e-26 -3.59991978393086 7.98217561727376e-15 miRanda -0.67979616494785 1.6009955849415e-21 NA NA NA hsa-miR-21-5p SLK 2.73773305747971 1.38864982139576e-43 -0.581760698176397 0.00182255373929412 miRNAWalker2_validate -0.179905163596315 1.26302010876799e-05 NA NA NA hsa-miR-21-5p SLMAP 2.73773305747971 1.38864982139576e-43 -1.93428348280594 2.36632563569771e-23 miRNAWalker2_validate -0.363384807742806 1.27123399804185e-16 NA NA NA hsa-miR-155-5p SMAD3 1.20164021433135 0.00086170622431261 -0.145068391221315 0.569239559252949 miRNAWalker2_validate -0.167586664196246 6.20173080978562e-07 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-155-5p SMAD5 1.20164021433135 0.00086170622431261 -0.471478570121366 0.00167073887561032 miRNAWalker2_validate;miRTarBase -0.105993087947379 8.66287104836701e-08 20133617 Targeting of SMAD5 links microRNA 155 to the TGF beta pathway and lymphomagenesis; Using unbiased genome-wide approaches in DLBCL we discovered that the oncogenic microRNA-155 miR-155 directly targets the bone morphogenetic protein BMP-responsive transcriptional factor SMAD5; In confirmatory experiments RNAi-based SMAD5 knockdown recapitulated in vitro and in vivo the effects miR-155 overexpression; Furthermore in primary DLBCLs miR-155 overexpression inhibited SMAD5 expression and disrupted its activity as defined by individual and global analyses of its transcriptional targets; Together our data helped explain miR-155 function highlighted a hitherto unappreciated role of SMAD5 in lymphoma biology and defined a unique mechanism used by cancer cells to escape TGF-beta's growth-inhibitory effects lymphoma hsa-miR-15b-5p SMAD7 1.57112623124278 9.14247846750597e-13 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate -0.31270512309151 3.09745138070762e-11 NA NA NA hsa-miR-21-5p SMAD7 2.73773305747971 1.38864982139576e-43 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate -0.100676973983357 0.0424364871556223 23372687;27185036;26531758 Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MicroRNA 21 Regulates Non Small Cell Lung Cancer Cell Invasion and Chemo Sensitivity through SMAD7; We performed bioinformatics analyses on the binding of microRNA-21 miR-21 to the 3'-UTR of SMAD7 mRNA and verified the biological effects of this binding using promoter luciferase reporter assay; Furthermore expression of miR-21 was found to be inhibited by Carboplatin and bioinformatics analyses showed that miR-21 targeted the 3'-UTR of SMAD7 mRNA to inhibit its translation which was confirmed by luciferase reporter assay; Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFβ receptor signaling mediated NSCLC cell invasion;MicroRNA 21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF β pathways; The present study was undertaken to determine the association of miR-21 smad7 EGF and TGF-β with breast cancer cell invasion and migration and to identify the molecular mechanisms involved using immunohistochemistry and western blot analysis; Smad7 was confirmed to be a direct target of miR-21 by luciferase reporter and western blot assays; The downregulation of smad7 by miR-21 or sismad7 enhanced EGF-dependent invasion and migration as well as TGF-β-dependent invasion and migration; The actions of miR-21 were abrogated by expressing a modified smad7 cDNA resistant to miR-21; In conclusion our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7 which enhances EGF and TGF-β pathways ;; breast cancer;lung squamous cell cancer;breast cancer hsa-miR-155-5p SMARCE1 1.20164021433135 0.00086170622431261 0.209816799074875 0.066826039459218 miRNAWalker2_validate -0.112656349732596 2.24359953518129e-14 NA NA NA hsa-miR-28-5p SMC3 0.230152919654905 0.0742909586754846 0.188489087089271 0.252993138933612 miRanda -0.152850866516808 0.0164864207131967 NA NA NA hsa-miR-28-5p SMURF2 0.230152919654905 0.0742909586754846 0.199209551479447 0.178208231024668 miRanda -0.127080382084809 0.0263023942977529 NA NA NA hsa-miR-375 SNAI2 1.13910305294079 0.0512283522214186 -0.280307189347724 0.489884936104145 miRanda -0.160294717693396 1.3349557949902e-06 NA NA NA hsa-miR-28-5p SNAPC3 0.230152919654905 0.0742909586754846 -0.19136154977709 0.220774582383818 miRanda -0.139183256687501 0.0212312765400364 NA NA NA hsa-miR-21-5p SNRK 2.73773305747971 1.38864982139576e-43 -1.02568516355149 6.87912222257906e-16 miRNAWalker2_validate -0.213480268872275 4.2542459484922e-14 NA NA NA hsa-miR-28-5p SNX19 0.230152919654905 0.0742909586754846 -0.699841224421871 0.000311447956960131 miRanda -0.177081154883874 0.0192186324110262 NA NA NA hsa-miR-107 SOCS2 1.30977326593435 1.30372468603965e-11 -1.54257627842132 8.29642001529314e-06 miRanda -0.207921979507507 0.0159466638019614 NA NA NA hsa-miR-16-5p SOCS2 1.75824877145857 1.68592440033108e-16 -1.54257627842132 8.29642001529314e-06 miRNAWalker2_validate -0.227430585509098 0.00310674955062147 NA NA NA hsa-miR-320b SOCS2 1.55692969039548 1.41071034251915e-08 -1.54257627842132 8.29642001529314e-06 miRanda -0.193818413512278 0.00140195309992275 NA NA NA hsa-miR-21-5p SOCS4 2.73773305747971 1.38864982139576e-43 -0.3499734105495 0.00323916823545163 miRNAWalker2_validate -0.108222135460776 3.52817869913008e-05 NA NA NA hsa-miR-21-5p SOCS5 2.73773305747971 1.38864982139576e-43 -0.491967856882936 4.91892319443221e-05 miRNAWalker2_validate -0.142823112988024 8.09014151494991e-08 NA NA NA hsa-miR-129-5p SORBS1 -0.524170159980738 0.222582956006346 -4.15864807654894 4.35930783508316e-19 miRanda -0.222937028228514 6.20410123287457e-05 NA NA NA hsa-miR-320a SORBS1 0.438165828017084 0.0390159073347133 -4.15864807654894 4.35930783508316e-19 miRNAWalker2_validate -0.806036493364451 1.34087674876374e-13 NA NA NA hsa-miR-339-5p SORBS1 2.68710938429893 3.03134080808154e-16 -4.15864807654894 4.35930783508316e-19 miRanda -0.677512636997644 2.95918069471095e-25 NA NA NA hsa-miR-361-5p SORBS1 0.971859117235239 5.30236555707088e-09 -4.15864807654894 4.35930783508316e-19 miRanda -1.54950144177824 2.83665864009657e-32 NA NA NA hsa-miR-421 SORBS1 1.17791565395543 6.78526676976629e-06 -4.15864807654894 4.35930783508316e-19 miRanda -0.588787284379431 2.00228403434674e-11 NA NA NA hsa-miR-542-3p SORBS1 1.18832665895751 1.98700670691565e-07 -4.15864807654894 4.35930783508316e-19 miRanda -0.400402963206204 8.58159017679136e-05 NA NA NA hsa-miR-590-3p SORBS1 2.59289455139753 1.03200520972022e-21 -4.15864807654894 4.35930783508316e-19 miRanda -1.01495412927387 4.98622166639023e-39 NA NA NA hsa-miR-590-5p SORBS1 3.18300989862077 2.06813568597893e-26 -4.15864807654894 4.35930783508316e-19 miRanda -0.960557236977759 6.3999158400918e-45 NA NA NA hsa-miR-320b SOSTDC1 1.55692969039548 1.41071034251915e-08 -4.35594448764447 4.5649960616463e-10 miRanda -0.368611027073898 0.00296560425388498 NA NA NA hsa-miR-590-3p SOSTDC1 2.59289455139753 1.03200520972022e-21 -4.35594448764447 4.5649960616463e-10 miRanda -0.275042021102899 0.0279919933604251 NA NA NA hsa-miR-326 SOX10 0.715313016136042 0.0610265683213359 -5.57653069718795 1.76659630016368e-21 miRanda -0.217592377367225 0.005557042588899 NA NA NA hsa-miR-330-5p SOX10 1.15100069700871 4.85551805046014e-07 -5.57653069718795 1.76659630016368e-21 miRanda -0.809337864676757 1.95043801581443e-10 NA NA NA hsa-miR-590-3p SOX10 2.59289455139753 1.03200520972022e-21 -5.57653069718795 1.76659630016368e-21 miRanda -0.919279473550998 6.76889888748111e-19 NA NA NA hsa-miR-21-5p SOX5 2.73773305747971 1.38864982139576e-43 -2.80899915084138 3.69546336813367e-12 miRNAWalker2_validate;miRTarBase -0.653702536707868 3.11070039398158e-13 NA NA NA hsa-miR-28-5p SOX6 0.230152919654905 0.0742909586754846 -2.16170894059309 7.49520430040923e-06 miRanda -0.594933023141159 0.00161877423836091 NA NA NA hsa-miR-484 SPAG9 1.81844463411787 1.82951571230938e-15 -0.566003160681759 6.52868939684676e-05 miRNAWalker2_validate -0.104514988177842 0.000340859763938415 NA NA NA hsa-miR-375 SPESP1 1.13910305294079 0.0512283522214186 -1.11781564920448 0.0697339450630137 miRanda -0.135509034540583 0.00779336054635464 NA NA NA hsa-miR-21-5p SPG11 2.73773305747971 1.38864982139576e-43 -0.332934806377567 0.0176823216998099 miRNAWalker2_validate -0.141803570813814 4.19092576672227e-06 NA NA NA hsa-miR-484 SPHK1 1.81844463411787 1.82951571230938e-15 0.88272290531505 0.0549040779437606 miRNAWalker2_validate -0.315664190371172 0.000829712011380627 NA NA NA hsa-miR-484 SPIRE1 1.81844463411787 1.82951571230938e-15 -0.866460105442462 0.00237060256142218 miRNAWalker2_validate -0.285860091863105 9.23515935791161e-07 NA NA NA hsa-miR-148a-3p SPRY2 1.26728238710376 2.52325607402829e-06 -1.56677647796773 2.28758561626214e-07 miRNAWalker2_validate -0.138147925228463 0.0116832538888583 NA NA NA hsa-miR-181a-5p SPRY2 2.29556023480783 1.8138457900616e-21 -1.56677647796773 2.28758561626214e-07 miRNAWalker2_validate -0.131191731454816 0.0260037188855004 NA NA NA hsa-miR-21-5p SPRY2 2.73773305747971 1.38864982139576e-43 -1.56677647796773 2.28758561626214e-07 miRNAWalker2_validate;miRTarBase -0.293552101879134 1.42915082637336e-05 22322462 Inhibition of microRNA-21 mir‑21 induced upregulation of Spry2 and PTEN which underscores the importance of mir-21 in Spry2-associated tumorigenesis of the colon tumorigenesis colon cancer hsa-miR-27a-3p SPRY2 1.66542180327138 4.93775737894805e-13 -1.56677647796773 2.28758561626214e-07 miRNAWalker2_validate;miRTarBase -0.131511034966349 0.0373243156859752 20638779 By using a reporter-screening assay we discovered that the 3'UTR of Sprouty2 Spry2 carried a putative miR-27a binding site; Furthermore the Spry2 protein which has a low expression level in pancreatic adenocarcinoma was upregulated by transfection with a miR-27a inhibitor; The data reported here are the first to indicate that miR-27a plays an oncogenic role by targeting Spry2 and modulating the malignant biological behavior of pancreatic cancer cells malignant trasformation pancreatic cancer hsa-miR-326 SPRY2 0.715313016136042 0.0610265683213359 -1.56677647796773 2.28758561626214e-07 miRanda -0.1988144651405 2.65654161630311e-07 NA NA NA hsa-miR-330-5p SPRY2 1.15100069700871 4.85551805046014e-07 -1.56677647796773 2.28758561626214e-07 miRanda -0.238730845891666 0.000204738921064239 NA NA NA hsa-miR-429 SPRY2 4.48815175680773 2.44117492218206e-17 -1.56677647796773 2.28758561626214e-07 miRanda -0.109821099297924 3.98906467298285e-05 NA NA NA hsa-miR-590-3p SPRY2 2.59289455139753 1.03200520972022e-21 -1.56677647796773 2.28758561626214e-07 miRanda -0.275012966495044 2.2537618212996e-07 NA NA NA hsa-miR-590-5p SPRY2 3.18300989862077 2.06813568597893e-26 -1.56677647796773 2.28758561626214e-07 miRanda -0.272789623553336 7.69009009350228e-09 NA NA NA hsa-miR-26a-5p SPTBN1 0.0464832722967259 0.752628386912329 -0.735351026844664 0.000347171300601555 miRNAWalker2_validate -0.157357918645039 0.0237055778404127 NA NA NA hsa-miR-320a SPTBN1 0.438165828017084 0.0390159073347133 -0.735351026844664 0.000347171300601555 miRanda -0.164742602800771 0.000497743896830894 NA NA NA hsa-miR-320b SPTBN1 1.55692969039548 1.41071034251915e-08 -0.735351026844664 0.000347171300601555 miRanda -0.123989388304462 0.000534470839012548 NA NA NA hsa-miR-34a-5p SPTBN1 1.9016323452565 1.43092834643601e-14 -0.735351026844664 0.000347171300601555 miRNAWalker2_validate -0.199718395817061 2.79500301041961e-07 NA NA NA hsa-miR-361-5p SPTBN1 0.971859117235239 5.30236555707088e-09 -0.735351026844664 0.000347171300601555 miRanda -0.147250650514647 0.0140749931279116 NA NA NA hsa-miR-423-3p SPTBN1 2.57855385753676 9.19765570228097e-24 -0.735351026844664 0.000347171300601555 miRNAWalker2_validate -0.148747802649693 5.19394770599785e-05 NA NA NA hsa-miR-590-3p SPTBN1 2.59289455139753 1.03200520972022e-21 -0.735351026844664 0.000347171300601555 miRanda -0.112225611868347 0.00187321852489002 NA NA NA hsa-miR-93-5p SPTBN1 3.03961860136032 1.11672209617395e-24 -0.735351026844664 0.000347171300601555 miRNAWalker2_validate -0.130932475675381 3.55469794288905e-05 NA NA NA hsa-miR-28-5p SPTLC1 0.230152919654905 0.0742909586754846 0.199376204549205 0.128705338560963 miRanda -0.1687927372647 0.000830946431738102 NA NA NA hsa-miR-200a-3p SRF 4.59434485520731 6.38952518573476e-18 -1.54762802860391 1.84904741152095e-30 miRTarBase -0.146541248340303 4.81881096872603e-37 NA NA NA hsa-miR-484 SRF 1.81844463411787 1.82951571230938e-15 -1.54762802860391 1.84904741152095e-30 miRNAWalker2_validate -0.245504194874069 1.03435721154639e-17 NA NA NA hsa-miR-107 SRPX 1.30977326593435 1.30372468603965e-11 -3.69666497795325 1.31877522468657e-13 miRanda -1.03520237643076 2.5235876777888e-17 NA NA NA hsa-miR-129-5p SRPX -0.524170159980738 0.222582956006346 -3.69666497795325 1.31877522468657e-13 miRanda -0.197173963791633 0.000829584464191445 NA NA NA hsa-miR-26b-5p SRPX 0.885393662798425 3.2116297961629e-06 -3.69666497795325 1.31877522468657e-13 miRNAWalker2_validate -0.849704809239333 3.61358704682009e-11 NA NA NA hsa-miR-320a SRPX 0.438165828017084 0.0390159073347133 -3.69666497795325 1.31877522468657e-13 miRanda -0.773128324174158 2.39131809316458e-11 NA NA NA hsa-miR-320b SRPX 1.55692969039548 1.41071034251915e-08 -3.69666497795325 1.31877522468657e-13 miRanda -0.694119129389358 1.09087282432812e-15 NA NA NA hsa-miR-421 SRPX 1.17791565395543 6.78526676976629e-06 -3.69666497795325 1.31877522468657e-13 miRanda -0.454143301167342 1.33970013675938e-06 NA NA NA hsa-miR-28-5p SSBP2 0.230152919654905 0.0742909586754846 -1.50095838408439 5.47169471767289e-08 miRanda -0.280344530182676 0.00991491853968397 NA NA NA hsa-miR-28-5p SSRP1 0.230152919654905 0.0742909586754846 0.48420163899696 0.000158064469617885 miRanda -0.129571542061131 0.00925642055487263 NA NA NA hsa-miR-484 ST3GAL2 1.81844463411787 1.82951571230938e-15 -0.445772259800494 0.0300266062096944 miRNAWalker2_validate -0.112423412775657 0.00779019599690424 NA NA NA hsa-miR-28-5p ST7 0.230152919654905 0.0742909586754846 0.0794550970829278 0.43501334948923 miRanda -0.100645582965731 0.0100455783819641 NA NA NA hsa-miR-21-5p STAG2 2.73773305747971 1.38864982139576e-43 -0.338909993805473 0.122578778455043 miRNAWalker2_validate -0.121496795603237 0.0125257945480539 NA NA NA hsa-miR-28-5p STARD4 0.230152919654905 0.0742909586754846 -0.144312845995392 0.70429491002691 miRanda -0.699469427992483 1.60427857622561e-06 NA NA NA hsa-miR-28-5p STC1 0.230152919654905 0.0742909586754846 -1.55340441030689 1.29077994156941e-05 miRanda -0.441308844074132 0.00151386722898138 NA NA NA hsa-miR-183-5p STK33 4.19757025992371 4.79612296318304e-26 -2.37554924253654 1.44451731113546e-05 miRNAWalker2_validate -0.271925129383877 1.4784315406011e-05 NA NA NA hsa-miR-183-5p STK40 4.19757025992371 4.79612296318304e-26 -1.26400207575733 1.00508386470648e-16 miRNAWalker2_validate -0.114407403706615 9.23378042242142e-11 NA NA NA hsa-miR-28-5p STOM 0.230152919654905 0.0742909586754846 -1.35582063522137 1.10537651475554e-05 miRanda -0.497285788465775 3.40430759591968e-05 NA NA NA hsa-miR-375 STON1 1.13910305294079 0.0512283522214186 -2.782863795679 1.20442176766979e-13 miRanda -0.133936633035845 2.44688788764453e-05 NA NA NA hsa-miR-484 STRN 1.81844463411787 1.82951571230938e-15 -0.295089884795449 0.279651425137409 miRNAWalker2_validate -0.120797473189 0.0314337975244027 NA NA NA hsa-miR-375 STX11 1.13910305294079 0.0512283522214186 -1.38043484022093 2.37846913193766e-05 miRanda -0.102898083452196 0.00014551058277326 NA NA NA hsa-miR-15b-5p STXBP1 1.57112623124278 9.14247846750597e-13 -1.49894536197603 7.34819776156861e-06 miRNAWalker2_validate -0.305688025206914 2.38048639861575e-05 NA NA NA hsa-miR-21-5p STXBP5 2.73773305747971 1.38864982139576e-43 -0.345490351478698 0.0579748459627733 miRNAWalker2_validate -0.144742656291492 0.000321062514771084 NA NA NA hsa-miR-28-5p SUGT1 0.230152919654905 0.0742909586754846 0.220932142899641 0.0778516490548841 miRanda -0.134720705182905 0.00529427712872382 NA NA NA hsa-miR-375 SULF1 1.13910305294079 0.0512283522214186 0.171691676108908 0.757613998121678 miRanda -0.145842392829084 0.00144935797769505 NA NA NA hsa-miR-107 SVEP1 1.30977326593435 1.30372468603965e-11 -3.27273373496198 2.12560279047744e-17 miRanda -0.670747553824141 3.95612125740543e-12 NA NA NA hsa-miR-320a SVEP1 0.438165828017084 0.0390159073347133 -3.27273373496198 2.12560279047744e-17 miRanda -0.490980843986318 7.04979062894882e-08 NA NA NA hsa-miR-320b SVEP1 1.55692969039548 1.41071034251915e-08 -3.27273373496198 2.12560279047744e-17 miRanda -0.4969513614898 2.61567408824383e-13 NA NA NA hsa-miR-330-5p SVEP1 1.15100069700871 4.85551805046014e-07 -3.27273373496198 2.12560279047744e-17 miRanda -0.467214252855229 1.97143218100646e-08 NA NA NA hsa-miR-339-5p SVEP1 2.68710938429893 3.03134080808154e-16 -3.27273373496198 2.12560279047744e-17 miRanda -0.349724282365064 4.0655923321779e-10 NA NA NA hsa-miR-342-3p SVEP1 1.49115144672245 1.43879249744621e-07 -3.27273373496198 2.12560279047744e-17 miRanda -0.148994635526861 0.0281010670821678 NA NA NA hsa-miR-421 SVEP1 1.17791565395543 6.78526676976629e-06 -3.27273373496198 2.12560279047744e-17 miRanda -0.325218063267542 9.4872650712925e-06 NA NA NA hsa-miR-429 SVEP1 4.48815175680773 2.44117492218206e-17 -3.27273373496198 2.12560279047744e-17 miRanda -0.30475794043465 1.39194244842719e-19 NA NA NA hsa-miR-590-3p SVEP1 2.59289455139753 1.03200520972022e-21 -3.27273373496198 2.12560279047744e-17 miRanda -0.462247800776156 1.74962357746858e-11 NA NA NA hsa-miR-590-5p SVEP1 3.18300989862077 2.06813568597893e-26 -3.27273373496198 2.12560279047744e-17 miRanda -0.489614012038466 6.82714342715908e-16 NA NA NA hsa-miR-484 SYNE2 1.81844463411787 1.82951571230938e-15 -0.381691294548014 0.0787393265300737 miRNAWalker2_validate -0.170002738499223 0.000129363091889122 NA NA NA hsa-miR-129-5p SYNM -0.524170159980738 0.222582956006346 -5.4236169146162 3.13314355922436e-24 miRanda -0.18861829821671 0.003696279353575 NA NA NA hsa-miR-193a-3p SYNM 1.60460546928078 2.86169793322984e-07 -5.4236169146162 3.13314355922436e-24 miRanda -0.278108778607005 0.00129066542339862 NA NA NA hsa-miR-320a SYNM 0.438165828017084 0.0390159073347133 -5.4236169146162 3.13314355922436e-24 miRanda -0.980517024400907 7.56857612887653e-15 NA NA NA hsa-miR-320b SYNM 1.55692969039548 1.41071034251915e-08 -5.4236169146162 3.13314355922436e-24 miRanda -0.989676661403679 1.06858399916806e-26 NA NA NA hsa-miR-324-5p SYNM 2.95683728155095 1.32960514360912e-20 -5.4236169146162 3.13314355922436e-24 miRanda -0.972844029945977 1.88409462986598e-38 NA NA NA hsa-miR-331-3p SYNM 2.28379581858927 1.99663919173155e-18 -5.4236169146162 3.13314355922436e-24 miRNAWalker2_validate -1.24632803382604 1.75909186731328e-42 NA NA NA hsa-miR-429 SYNM 4.48815175680773 2.44117492218206e-17 -5.4236169146162 3.13314355922436e-24 miRanda -0.572381351363235 2.35293299400324e-36 NA NA NA hsa-miR-486-5p SYNM -0.194913133034028 0.607377798807705 -5.4236169146162 3.13314355922436e-24 miRanda -0.27082558866639 0.000169752159770465 NA NA NA hsa-miR-375 SYT9 1.13910305294079 0.0512283522214186 -2.33894542005822 7.73132502492019e-05 miRanda -0.120429358433688 0.0145382813842016 NA NA NA hsa-miR-28-5p TAB2 0.230152919654905 0.0742909586754846 -0.497820735092303 4.52715454335717e-05 miRanda -0.116214435148468 0.0143724242565357 NA NA NA hsa-miR-21-5p TAF1 2.73773305747971 1.38864982139576e-43 -0.352867829040564 0.021343778303789 miRNAWalker2_validate -0.168605868292199 5.21139658487988e-07 NA NA NA hsa-miR-28-5p TAGLN3 0.230152919654905 0.0742909586754846 0.668447314205393 0.262174844197762 miRanda -0.494801228316443 0.0324266447014778 NA NA NA hsa-miR-425-5p TAOK1 3.07071373939774 4.02947460586085e-25 -0.507192494879209 0.107943198436468 miRNAWalker2_validate -0.106109186458782 0.0291360591037206 NA NA NA hsa-miR-28-5p TAP1 0.230152919654905 0.0742909586754846 0.854282589514772 0.0128296239550172 miRanda -0.400524834568231 0.00263294656440642 NA NA NA hsa-miR-484 TBC1D2B 1.81844463411787 1.82951571230938e-15 -0.40099777404856 0.00580256979159291 miRNAWalker2_validate -0.137758797118084 3.3142598335e-06 NA NA NA hsa-miR-21-5p TCF21 2.73773305747971 1.38864982139576e-43 -4.43944664880256 2.76743163205812e-24 miRNAWalker2_validate -0.800230451615305 7.64982890189738e-16 NA NA NA hsa-miR-28-5p TCF4 0.230152919654905 0.0742909586754846 -1.61270531688003 6.6047419057989e-09 miRanda -0.24392273184964 0.026347945813452 NA NA NA hsa-miR-200a-3p TCF7L1 4.59434485520731 6.38952518573476e-18 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.31712696382727 2.57417137844588e-28 NA NA NA hsa-miR-200b-3p TCF7L1 3.78235093249346 3.18343003239465e-14 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.344042033030514 1.2723812194927e-28 NA NA NA hsa-miR-338-3p TCF7L2 0.453166438193782 0.144583389707558 -0.0989663661080726 0.582291209673574 miRanda -0.114047090229425 4.18397743027561e-05 NA NA NA hsa-miR-28-5p TEP1 0.230152919654905 0.0742909586754846 -0.314497002887021 0.0681626549097023 miRanda -0.351963505468236 9.09860504705177e-08 NA NA NA hsa-miR-484 TEP1 1.81844463411787 1.82951571230938e-15 -0.314497002887021 0.0681626549097023 miRNAWalker2_validate -0.205275451193531 3.76123567618791e-09 NA NA NA hsa-miR-21-5p TESK2 2.73773305747971 1.38864982139576e-43 0.182763813259518 0.45321012091712 miRNAWalker2_validate -0.105954896913282 0.049966806434361 NA NA NA hsa-miR-28-5p TFAM 0.230152919654905 0.0742909586754846 0.397800981613041 0.00444444927816057 miRanda -0.110757167295313 0.0412112537664545 NA NA NA hsa-miR-28-5p TFDP1 0.230152919654905 0.0742909586754846 0.846227916601966 2.69648378919315e-07 miRanda -0.177316566489884 0.00596177796758454 NA NA NA hsa-miR-28-5p TFEB 0.230152919654905 0.0742909586754846 -1.17428775837471 1.22197070880587e-05 miRanda -0.39225768327455 0.000176465484795603 NA NA NA hsa-miR-106a-5p TGFBR2 2.48882002962836 1.99757727374521e-12 -1.5612933795263 2.09571393414153e-11 miRTarBase -0.174237668172683 2.7024970040951e-08 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-107 TGFBR2 1.30977326593435 1.30372468603965e-11 -1.5612933795263 2.09571393414153e-11 miRanda -0.33082940368913 1.15759545655126e-08 NA NA NA hsa-miR-130b-3p TGFBR2 3.5350292994509 1.73934183852569e-27 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.279678154840768 1.9762101701233e-18 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 3.2710598467455 9.93128340539455e-27 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase -0.302277707820119 6.79145607037112e-19 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-18a-5p TGFBR2 3.78535678765353 3.72446596213886e-26 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.25381972833671 2.41323249210829e-16 NA NA NA hsa-miR-19a-3p TGFBR2 3.42309334186656 3.02671914353412e-28 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.277232207383645 1.48488496649533e-16 NA NA NA hsa-miR-19b-3p TGFBR2 2.49529833021187 1.57028265846699e-23 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.351923320676886 1.03809079896527e-16 NA NA NA hsa-miR-20a-5p TGFBR2 3.15577933619191 4.19753346442454e-25 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase -0.29433840605417 1.11976352607645e-17 NA NA NA hsa-miR-21-5p TGFBR2 2.73773305747971 1.38864982139576e-43 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase -0.1959869038848 0.000202473977886908 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-320a TGFBR2 0.438165828017084 0.0390159073347133 -1.5612933795263 2.09571393414153e-11 miRanda -0.147256255771787 0.0072521693939925 NA NA NA hsa-miR-320b TGFBR2 1.55692969039548 1.41071034251915e-08 -1.5612933795263 2.09571393414153e-11 miRanda -0.259785049714809 1.72104577406335e-10 NA NA NA hsa-miR-335-5p TGFBR2 1.77247705492746 2.22457658872091e-06 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.108328975461909 0.000362366652132911 NA NA NA hsa-miR-590-3p TGFBR2 2.59289455139753 1.03200520972022e-21 -1.5612933795263 2.09571393414153e-11 miRanda -0.298641027773627 2.0141780556407e-13 NA NA NA hsa-miR-590-5p TGFBR2 3.18300989862077 2.06813568597893e-26 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;miRanda -0.294796030766598 2.66958610835318e-16 NA NA NA hsa-miR-92a-3p TGFBR2 2.06460102658973 1.44784291084757e-19 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.402171657787311 8.61853387794715e-18 NA NA NA hsa-miR-93-5p TGFBR2 3.03961860136032 1.11672209617395e-24 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.345215781740609 4.92958365930485e-23 NA NA NA hsa-miR-181a-5p TGFBR3 2.29556023480783 1.8138457900616e-21 -2.59061685335061 7.44943414202018e-11 miRNAWalker2_validate -0.533327553140963 2.53974355292015e-12 NA NA NA hsa-miR-193a-3p TGFBR3 1.60460546928078 2.86169793322984e-07 -2.59061685335061 7.44943414202018e-11 miRanda -0.404117628316179 3.34660410567723e-11 NA NA NA hsa-miR-193b-3p TGFBR3 2.25711804611899 4.1940744806631e-14 -2.59061685335061 7.44943414202018e-11 miRNAWalker2_validate -0.54263409776695 1.06348017136205e-18 NA NA NA hsa-miR-21-5p TGFBR3 2.73773305747971 1.38864982139576e-43 -2.59061685335061 7.44943414202018e-11 miRNAWalker2_validate -0.873696976080408 1.42070935389156e-24 NA NA NA hsa-miR-338-3p TGFBR3 0.453166438193782 0.144583389707558 -2.59061685335061 7.44943414202018e-11 miRanda -0.32591907256696 2.15757294303162e-07 NA NA NA hsa-miR-339-5p TGFBR3 2.68710938429893 3.03134080808154e-16 -2.59061685335061 7.44943414202018e-11 miRanda -0.261061195001236 5.31993152374657e-06 NA NA NA hsa-miR-34c-5p TGFBR3 2.07190852984647 7.35776320806257e-08 -2.59061685335061 7.44943414202018e-11 miRanda -0.277892023741616 1.74141696542429e-07 NA NA NA hsa-miR-455-5p TGFBR3 2.2582442061694 1.43472128037398e-13 -2.59061685335061 7.44943414202018e-11 miRanda -0.595169359534449 1.29501226263914e-23 NA NA NA hsa-miR-590-3p TGFBR3 2.59289455139753 1.03200520972022e-21 -2.59061685335061 7.44943414202018e-11 miRanda -0.471663498128764 1.30242745091055e-11 NA NA NA hsa-miR-590-5p TGFBR3 3.18300989862077 2.06813568597893e-26 -2.59061685335061 7.44943414202018e-11 miRanda -0.399800495757582 1.45902129417123e-10 NA NA NA hsa-miR-28-5p TGM2 0.230152919654905 0.0742909586754846 -1.14690935857596 0.0144751654848477 miRanda -0.640159119578279 0.00042404334773368 NA NA NA hsa-miR-375 TGM2 1.13910305294079 0.0512283522214186 -1.14690935857596 0.0144751654848477 miRNAWalker2_validate -0.145727264597735 0.000162738183157484 NA NA NA hsa-miR-375 THBS1 1.13910305294079 0.0512283522214186 -2.1277814514878 2.63898598170147e-08 miRanda -0.150506420398144 2.2392975982835e-06 NA NA NA hsa-miR-15b-5p THRA 1.57112623124278 9.14247846750597e-13 -1.80486534711542 1.86472212451361e-16 miRNAWalker2_validate -0.362758401648543 2.51073590952179e-14 NA NA NA hsa-miR-21-5p TIAM1 2.73773305747971 1.38864982139576e-43 0.26066582137389 0.380250873765661 miRNAWalker2_validate;miRTarBase -0.142345003811758 0.0307963704454132 20826792 miR 21 and miR 31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells; We present compelling evidence that TIAM1 a guanidine exchange factor of the Rac GTPase is a direct target of both miR-21 and miR-31 colon cancer hsa-miR-155-5p TJP1 1.20164021433135 0.00086170622431261 -0.702942121782242 1.25097615231369e-05 miRNAWalker2_validate -0.105893674916941 7.68827461583637e-07 NA NA NA hsa-miR-155-5p TLE4 1.20164021433135 0.00086170622431261 -1.39297888910606 1.25915545127355e-06 miRNAWalker2_validate -0.111946937339718 0.00393304879936991 NA NA NA hsa-miR-484 TLN1 1.81844463411787 1.82951571230938e-15 -1.45515106009239 3.18740725534339e-16 miRNAWalker2_validate -0.382358126101732 8.34776710503052e-27 NA NA NA hsa-miR-28-5p TLR6 0.230152919654905 0.0742909586754846 -0.160742740193349 0.68817495757853 miRanda -0.671197925008986 1.2997442803247e-05 NA NA NA hsa-miR-28-5p TM9SF1 0.230152919654905 0.0742909586754846 0.509283601668994 3.56834466293369e-06 miRanda -0.104985391481925 0.0141783409764518 NA NA NA hsa-miR-28-5p TMEM104 0.230152919654905 0.0742909586754846 0.851902908500058 2.90933334105153e-10 miRanda -0.107619821839775 0.0439109804390429 NA NA NA hsa-miR-183-5p TMEM108 4.19757025992371 4.79612296318304e-26 -2.78114300571125 1.45650573276381e-06 miRNAWalker2_validate -0.484604322848275 8.35829435063004e-14 NA NA NA hsa-miR-28-5p TMEM167A 0.230152919654905 0.0742909586754846 0.307097135955043 0.00256383086427742 miRanda -0.131943246024516 0.00076467072690815 NA NA NA hsa-miR-484 TMEM170B 1.81844463411787 1.82951571230938e-15 -0.889417316317811 0.00246966185092237 miRNAWalker2_validate -0.145400764086431 0.0165914554996517 NA NA NA hsa-miR-196a-5p TMEM2 1.52993069622497 0.00397268663639603 0.281326637586922 0.25839297367774 miRNAWalker2_validate -0.10176252259433 5.36751111163833e-06 NA NA NA hsa-miR-21-5p TMEM56 2.73773305747971 1.38864982139576e-43 -1.69013829359271 2.69484321718219e-05 miRNAWalker2_validate -0.517116020676155 5.57578956033091e-09 NA NA NA hsa-miR-484 TMOD2 1.81844463411787 1.82951571230938e-15 -1.02377830752032 1.97345844232229e-05 miRNAWalker2_validate -0.260869531502033 1.10140059395606e-07 NA NA NA hsa-miR-28-5p TMPRSS11D 0.230152919654905 0.0742909586754846 -1.08704950698677 0.193031839475232 miRanda -1.22191837995258 0.000149787174577036 NA NA NA hsa-miR-21-5p TMX4 2.73773305747971 1.38864982139576e-43 -0.933228791579491 1.34545470463139e-07 miRNAWalker2_validate -0.187685233938296 1.90816431314888e-06 NA NA NA hsa-miR-155-5p TNFAIP2 1.20164021433135 0.00086170622431261 0.972239360742627 0.00753213008034736 miRNAWalker2_validate -0.248206577302158 2.56419732089969e-07 NA NA NA hsa-miR-320a TNFRSF17 0.438165828017084 0.0390159073347133 -0.481693606916816 0.454561189195548 miRanda -0.457084273309111 0.00196860968945593 NA NA NA hsa-miR-320b TNFRSF17 1.55692969039548 1.41071034251915e-08 -0.481693606916816 0.454561189195548 miRanda -0.445221888056674 6.36392747775375e-05 NA NA NA hsa-miR-21-5p TNRC6B 2.73773305747971 1.38864982139576e-43 -0.609942718455402 9.71652582037636e-06 miRNAWalker2_validate -0.226470483348381 3.4910513639947e-14 NA NA NA hsa-miR-1301-3p TNXB 2.54959518791507 5.26618591274892e-18 -5.33950719719598 1.13608514104698e-23 miRNAWalker2_validate -0.811544767747683 9.14250138091737e-22 NA NA NA hsa-miR-28-5p TOE1 0.230152919654905 0.0742909586754846 -0.0907687367967496 0.479076591430887 miRanda -0.109474362324438 0.0268970603697193 NA NA NA hsa-miR-21-5p TOPORS 2.73773305747971 1.38864982139576e-43 -0.435269085642656 0.00175310030124193 miRNAWalker2_validate -0.113725567889912 0.000217012945897515 NA NA NA hsa-miR-155-5p TP53INP1 1.20164021433135 0.00086170622431261 0.25320182094875 0.232216235702386 miRNAWalker2_validate;miRTarBase -0.122784844131676 1.20211660849563e-05 23209550;24152184;26195069;23568502;24551280;21412018;17911264;25601564 In addition miR-142-5p and miR-155 suppress the proapoptotic gene TP53INP1 as their target;TP53INP1 is the direct target of miR-155; MiR-155 which is overexpressed in MCF-7 cells contributes to proliferation of MCF-7 cells possibly through down-regulating target TP53INP1;TP53INP1 is a target of miR-155 in fibroblasts and a downregulation of TP53INP1 protein levels could contribute to the fibroblasts' activation;17β estradiol up regulates miR 155 expression and reduces TP53INP1 expression in MCF 7 breast cancer cells; Moreover TP53INP1 is one of the targets of miR-155; These results demonstrated that E2 promoted breast cancer development and progression possibly through increasing the expression of miR-155 which was overexpressed in MCF-7 cells contributes to proliferation of MCF-7 cells possibly through down-regulating TP53INP1;In addition miR-155 and TP53INP1 showed a negative relation in ESCC tissues; Dual luciferase-based reporter assay indicated direct regulation of TP53INP1 by miR-155; Taken together our study reveals that miR-155 acts as an oncogene by targeting TP53INP1 in ESCC;miR-21 and miR-155 expression was assessed in tumor tissue and in adjacent normal tissue of 156 CRC patients by TaqMan MicroRNA assays and PDCD4 and TP53INP1 mRNA levels were measured by quantitative real-time reverse transcriptase PCR RT-PCR; Significant inverse correlations were demonstrated between miR-21 and PDCD4 mRNA and miR-155 and TP53INP1 mRNA;Finally TP53INP1 expression is repressed by the oncogenic micro RNA miR-155 which is overexpressed in PDAC cells; TP53INP1 is a previously unknown miR-155 target presenting anti-tumoral activity;MiR 155 targets TP53INP1 to regulate liver cancer stem cell acquisition and self renewal; TP53INP1 was determined to be involved in the CSCs-like properties that were regulated by miR-155; Thus miR-155 may play an important role in promoting the generation of stem cell-like cells and their self-renewal by targeting the gene TP53INP1 ;;;progression;;;; lymphoma;breast cancer;pancreatic cancer;breast cancer;esophageal cancer;colorectal cancer;pancreatic cancer;liver cancer hsa-miR-28-5p TPD52L1 0.230152919654905 0.0742909586754846 -1.27939222572084 0.00136217565278109 miRanda -0.493118682576279 0.00149436176352653 NA NA NA hsa-miR-21-5p TPM1 2.73773305747971 1.38864982139576e-43 -2.65530585768087 2.50185615635583e-17 miRNAWalker2_validate;miRTarBase -0.289116342814918 5.96890063064487e-05 20952761;23558936 These two miRNAs have previously been identified as being overexpressed in MCF-7 breast cancer cells with miR-21 specifically implicated in down-regulating the tumor suppressor gene tropomyosin-1;Furthermore miR-21 mimic or inhibitor significantly reduced or increased the expression of PDCD4 and TPM1; MiR-21 is overexpressed in RCC tissue and modulates the growth apoptosis and cell cycle progression of RCC cells and regulates the expression of PDCD4 and TPM1 ;progression breast cancer;kidney renal cell cancer hsa-miR-375 TPM1 1.13910305294079 0.0512283522214186 -2.65530585768087 2.50185615635583e-17 miRanda -0.116184267571717 1.412558253733e-05 NA NA NA hsa-miR-16-5p TPPP3 1.75824877145857 1.68592440033108e-16 -2.02563093169564 2.49862787321168e-08 miRNAWalker2_validate;miRTarBase -0.425226568574523 1.22877953163695e-07 NA NA NA hsa-miR-330-5p TPPP3 1.15100069700871 4.85551805046014e-07 -2.02563093169564 2.49862787321168e-08 miRanda -0.163433684372655 0.0357114739616894 NA NA NA hsa-miR-21-5p TPRG1L 2.73773305747971 1.38864982139576e-43 -0.492001885100898 0.000316209720303883 miRNAWalker2_validate -0.117239077930982 0.000104997873071409 NA NA NA hsa-miR-28-5p TPST1 0.230152919654905 0.0742909586754846 -1.28287237745114 1.17818677890283e-06 miRanda -0.322887261201547 0.00178624651365288 NA NA NA hsa-miR-92b-3p TPT1 1.20409245530001 3.41055816361655e-06 -0.589405553676901 0.000523819360513231 miRNAWalker2_validate -0.253317838790136 9.68206036869279e-17 NA NA NA hsa-miR-155-5p TRAK1 1.20164021433135 0.00086170622431261 -0.0588813018905707 0.830751886792732 miRNAWalker2_validate -0.321715118407031 5.08714762608935e-20 NA NA NA hsa-miR-21-5p TRIM2 2.73773305747971 1.38864982139576e-43 -1.24600852758983 0.000109711849149996 miRNAWalker2_validate -0.405873841857808 1.03472527999958e-08 NA NA NA hsa-miR-28-5p TRIM23 0.230152919654905 0.0742909586754846 -0.671091371187086 1.11849461042915e-06 miRanda -0.215387587561052 5.82032898287257e-05 NA NA NA hsa-miR-155-5p TRIM24 1.20164021433135 0.00086170622431261 0.781304018033814 0.00281040912639483 miRNAWalker2_validate -0.151824586396998 1.27694276911239e-05 NA NA NA hsa-miR-21-5p TRIM33 2.73773305747971 1.38864982139576e-43 -0.0830465590238232 0.568322263884813 miRNAWalker2_validate -0.177798358672815 1.99073432100397e-08 NA NA NA hsa-miR-484 TRIM44 1.81844463411787 1.82951571230938e-15 -0.65549929625214 0.0026112531188157 miRNAWalker2_validate -0.155592362575683 0.000510690450655146 NA NA NA hsa-miR-183-5p TRO 4.19757025992371 4.79612296318304e-26 -1.09066363704497 0.00522034476633817 miRNAWalker2_validate -0.157799533615841 0.000404659753846071 NA NA NA hsa-miR-21-5p TRPM7 2.73773305747971 1.38864982139576e-43 -0.0519010114895044 0.728187765824727 miRNAWalker2_validate -0.171652240292465 1.36658801619227e-07 NA NA NA hsa-miR-28-5p TRPS1 0.230152919654905 0.0742909586754846 -2.16842073246699 1.62641545265475e-06 miRanda -0.714834105609216 5.09578050295903e-05 NA NA NA hsa-miR-484 TSC22D3 1.81844463411787 1.82951571230938e-15 -1.67435472404316 7.07551770315191e-11 miRNAWalker2_validate -0.395622430324705 4.80041751933447e-14 NA NA NA hsa-miR-28-5p TSG101 0.230152919654905 0.0742909586754846 -0.0492775600773205 0.635519737076906 miRanda -0.192770903938 1.08627550662434e-06 NA NA NA hsa-miR-21-5p TSHZ3 2.73773305747971 1.38864982139576e-43 -2.3826164042391 2.29782206551949e-10 miRNAWalker2_validate -0.254665340824338 0.00278039442827483 NA NA NA hsa-miR-375 TSHZ3 1.13910305294079 0.0512283522214186 -2.3826164042391 2.29782206551949e-10 miRanda -0.17068651160765 4.93377898053575e-08 NA NA NA hsa-miR-28-5p TSNAX 0.230152919654905 0.0742909586754846 -0.141085667338253 0.178122584773579 miRanda -0.147100476264828 0.000247110221347644 NA NA NA hsa-miR-196a-5p TSPAN12 1.52993069622497 0.00397268663639603 -0.476683900114947 0.259818782301913 miRNAWalker2_validate -0.169896788246216 8.06502773932074e-06 NA NA NA hsa-miR-155-5p TSPAN14 1.20164021433135 0.00086170622431261 0.379984820804368 0.0278363502200073 miRNAWalker2_validate -0.117464108893935 2.54046914172789e-07 NA NA NA hsa-miR-92b-3p TSPYL1 1.20409245530001 3.41055816361655e-06 -1.05696274950115 9.69488583124111e-15 miRNAWalker2_validate -0.109739115149135 2.27492916311374e-05 NA NA NA hsa-miR-15a-5p TSPYL2 2.34669284378787 1.69544424500258e-23 -1.65669303081451 9.67020189218457e-17 miRNAWalker2_validate -0.135942073438748 0.000776651522571173 NA NA NA hsa-miR-28-5p TTC23 0.230152919654905 0.0742909586754846 -0.590124503708959 0.000678415261933105 miRanda -0.183858650256622 0.00644919826370181 NA NA NA hsa-miR-21-5p TTC33 2.73773305747971 1.38864982139576e-43 -0.405612994401501 0.00651561171649612 miRNAWalker2_validate -0.170679176497682 1.74503294783632e-07 NA NA NA hsa-miR-28-5p TTLL5 0.230152919654905 0.0742909586754846 0.248525149508895 0.0333752622298827 miRanda -0.132019264793312 0.00336190322028071 NA NA NA hsa-miR-28-5p TUBGCP5 0.230152919654905 0.0742909586754846 0.150459504741407 0.259168136868145 miRanda -0.145381302353703 0.0046668757648161 NA NA NA hsa-miR-28-5p TULP4 0.230152919654905 0.0742909586754846 0.142389881867178 0.217599709668758 miRNAWalker2_validate -0.117192139470691 0.00839842164374742 NA NA NA hsa-miR-183-5p TXNIP 4.19757025992371 4.79612296318304e-26 -1.19206229218288 1.53140877295634e-05 miRNAWalker2_validate -0.163009366156381 2.11189783347501e-07 NA NA NA hsa-miR-15b-5p UACA 1.57112623124278 9.14247846750597e-13 -0.184212642048497 0.302812191960566 miRNAWalker2_validate -0.112605696602409 0.00334754753098064 NA NA NA hsa-miR-28-5p UBA6 0.230152919654905 0.0742909586754846 0.50633746367549 0.00328929606943201 miRanda -0.145129771432854 0.0301586213706661 NA NA NA hsa-miR-28-5p UBE2A 0.230152919654905 0.0742909586754846 0.413682581975414 0.00018417754223917 miRanda -0.106754531643722 0.0128304592438993 NA NA NA hsa-miR-28-5p UBE2Z 0.230152919654905 0.0742909586754846 0.200220590531371 0.0415186153521295 miRanda -0.155127161368637 3.61878901488175e-05 NA NA NA hsa-miR-28-5p UBE3C 0.230152919654905 0.0742909586754846 0.0168964018941073 0.896438918354356 miRanda -0.172267146732282 0.000549951557709974 NA NA NA hsa-miR-21-5p UBR3 2.73773305747971 1.38864982139576e-43 -0.622051125375518 1.56787261031666e-05 miRNAWalker2_validate -0.233047808388609 8.66593479273878e-14 NA NA NA hsa-miR-28-5p UBTD1 0.230152919654905 0.0742909586754846 0.242698575248668 0.23102081669779 miRanda -0.184234413975858 0.018830341751327 NA NA NA hsa-miR-28-5p UBTD2 0.230152919654905 0.0742909586754846 -0.0153333530649338 0.892380085064949 miRanda -0.147950564259447 0.000664392014397386 NA NA NA hsa-miR-15a-5p UGP2 2.34669284378787 1.69544424500258e-23 -0.597362337310919 1.0334585910266e-07 miRNAWalker2_validate -0.129685661192134 2.82042532351808e-09 NA NA NA hsa-miR-503-5p UHMK1 3.66513190181895 6.60300917645278e-21 0.164221229611865 0.683572614317993 miRNAWalker2_validate -0.127482619102048 0.0110321687059091 NA NA NA hsa-miR-28-5p UHRF2 0.230152919654905 0.0742909586754846 0.00319369678889014 0.984119918834702 miRanda -0.192800015590638 0.00181680036976756 NA NA NA hsa-miR-92b-3p UNC5B 1.20409245530001 3.41055816361655e-06 0.0581094561135398 0.822094854420426 miRNAWalker2_validate -0.145870951463024 0.00225362415682349 NA NA NA hsa-miR-28-5p USP12 0.230152919654905 0.0742909586754846 -1.44507046271225 1.43898976239535e-07 miRanda -0.349211669219181 0.00119540001611585 NA NA NA hsa-miR-21-5p USP34 2.73773305747971 1.38864982139576e-43 -0.281220182838029 0.0133833434747705 miRNAWalker2_validate -0.157189940756653 1.74080923295958e-10 NA NA NA hsa-miR-21-5p USP47 2.73773305747971 1.38864982139576e-43 -0.550418456692913 1.77548920010901e-07 miRNAWalker2_validate -0.176896815571991 9.55219026074455e-15 NA NA NA hsa-miR-21-5p USP7 2.73773305747971 1.38864982139576e-43 -0.195536027337183 0.143622494238901 miRNAWalker2_validate -0.125175884666887 1.97864094042819e-05 NA NA NA hsa-miR-28-5p USP9X 0.230152919654905 0.0742909586754846 -0.43609422421635 0.000267735131255018 miRanda -0.173657097548202 0.00017169151745244 NA NA NA hsa-miR-484 UTP14C 1.81844463411787 1.82951571230938e-15 -0.333949087543703 0.0191261691393172 miRNAWalker2_validate -0.105146629855177 0.000310114773328021 NA NA NA hsa-miR-21-5p UTRN 2.73773305747971 1.38864982139576e-43 -1.71907332573482 5.25779555734954e-11 miRNAWalker2_validate -0.348557968969184 2.51820055239615e-09 NA NA NA hsa-miR-484 UTRN 1.81844463411787 1.82951571230938e-15 -1.71907332573482 5.25779555734954e-11 miRNAWalker2_validate -0.380252640261538 1.51208948829219e-12 NA NA NA hsa-miR-21-5p VASH2 2.73773305747971 1.38864982139576e-43 0.222771247270826 0.590450827527917 miRNAWalker2_validate -0.339968143302069 0.000198194581483819 NA NA NA hsa-miR-200a-3p VCAM1 4.59434485520731 6.38952518573476e-18 -1.46399567013403 0.000518642539259761 miRNAWalker2_validate -0.343011191298116 1.26094779693856e-22 NA NA NA hsa-miR-28-5p VCAN 0.230152919654905 0.0742909586754846 0.102699847387805 0.827138258538118 miRanda -0.494003242839762 0.00664701722149698 NA NA NA hsa-miR-155-5p VEZF1 1.20164021433135 0.00086170622431261 -0.623680936997776 2.54341270614942e-07 miRNAWalker2_validate -0.101368559579356 2.30304972888631e-10 NA NA NA hsa-miR-28-5p VEZT 0.230152919654905 0.0742909586754846 -0.0285160905831274 0.812403542240672 miRanda -0.138951657066808 0.0026261095376969 NA NA NA hsa-miR-21-5p VPS13A 2.73773305747971 1.38864982139576e-43 -0.277026505331682 0.16902796153012 miRNAWalker2_validate -0.211045197066275 1.78843563402616e-06 NA NA NA hsa-miR-28-5p VPS13D 0.230152919654905 0.0742909586754846 -0.873698098644587 1.82957568574832e-11 miRanda -0.108969882287371 0.0344261799046572 NA NA NA hsa-miR-155-5p VPS36 1.20164021433135 0.00086170622431261 -0.634071118931554 0.000251145906849977 miRNAWalker2_validate -0.11546307610861 5.04740655716124e-07 NA NA NA hsa-miR-21-5p VPS36 2.73773305747971 1.38864982139576e-43 -0.634071118931554 0.000251145906849977 miRNAWalker2_validate -0.199131019827908 1.75934789260888e-07 NA NA NA hsa-miR-425-5p WASF2 3.07071373939774 4.02947460586085e-25 -0.801854983583159 1.10831629491092e-05 miRNAWalker2_validate -0.189877356958179 6.63175268060768e-12 NA NA NA hsa-miR-200a-3p WASF3 4.59434485520731 6.38952518573476e-18 -1.29629914639685 0.000157361069159746 miRNAWalker2_validate;miRTarBase -0.100947948947868 0.000753808151182337 NA NA NA hsa-miR-28-5p WDR26 0.230152919654905 0.0742909586754846 -0.301887044634931 0.00343012035674469 miRanda -0.115283985198336 0.00375898976607878 NA NA NA hsa-miR-21-5p WDR7 2.73773305747971 1.38864982139576e-43 -0.746210786074613 2.67505397594911e-07 miRNAWalker2_validate -0.18984663009202 2.92764379753432e-09 NA NA NA hsa-miR-155-5p WEE1 1.20164021433135 0.00086170622431261 -1.40590862047516 1.76830074250163e-11 miRNAWalker2_validate -0.118659419923154 2.97968064982433e-05 NA NA NA hsa-miR-21-5p WFS1 2.73773305747971 1.38864982139576e-43 -0.820677327026441 7.70978584563792e-05 miRNAWalker2_validate -0.296244905739848 6.73051445629042e-11 NA NA NA hsa-miR-342-3p WIF1 1.49115144672245 1.43879249744621e-07 -2.76337442815502 6.05765104196789e-05 miRanda -0.299358758588009 0.0107015466025391 NA NA NA hsa-miR-15a-5p WIPF1 2.34669284378787 1.69544424500258e-23 -1.36396473341553 1.25828143739996e-05 miRNAWalker2_validate -0.429555399402037 9.67954952068467e-13 NA NA NA hsa-miR-21-5p WNK3 2.73773305747971 1.38864982139576e-43 -1.25332787095286 0.00861836442540923 miRNAWalker2_validate -0.540949360047189 2.5388119075337e-07 NA NA NA hsa-miR-28-5p WNT5B 0.230152919654905 0.0742909586754846 -2.10977851058083 2.85645296158293e-05 miRanda -0.530836498754109 0.00709692972406734 NA NA NA hsa-miR-155-5p WRB 1.20164021433135 0.00086170622431261 -0.189143130333952 0.210912413198555 miRNAWalker2_validate -0.113838697298281 9.12356089355166e-09 NA NA NA hsa-miR-15a-5p WT1 2.34669284378787 1.69544424500258e-23 0.551323653201556 0.432441907096104 miRNAWalker2_validate -0.59605011893962 1.26814902661351e-05 NA NA NA hsa-miR-200a-3p YAP1 4.59434485520731 6.38952518573476e-18 -0.819514922156015 7.72909626929227e-05 miRNAWalker2_validate -0.116465428459349 5.57675633205442e-11 23340296 MicroRNA 200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer; We identified Yes-associated protein 1 YAP1 as a novel target of miR-200a; Our data showed that targeting of YAP1 by miR-200a resulted in decreased expression of proapoptotic proteins which leads to anoikis resistance; Remarkably we found that YAP1 expression was inversely correlated with miR-200a expression in breast cancer clinical specimens and miR-200a expression was associated with distant metastasis in patients with breast cancer metastasis;drug resistance breast cancer hsa-miR-28-5p YBX1 0.230152919654905 0.0742909586754846 0.0373932416585472 0.788922052412928 miRanda -0.148812655518699 0.00569639587120725 NA NA NA hsa-miR-28-5p YLPM1 0.230152919654905 0.0742909586754846 -0.458036086972552 7.33474264078578e-05 miRanda -0.118593187563453 0.00819113886436635 NA NA NA hsa-miR-28-5p YRDC 0.230152919654905 0.0742909586754846 0.100022520446864 0.463778679255834 miRanda -0.182057353649716 0.000521736761389966 NA NA NA hsa-miR-28-5p YWHAH 0.230152919654905 0.0742909586754846 -0.039384739798634 0.787929142314944 miRanda -0.2331357688511 3.2675565751886e-05 NA NA NA hsa-miR-28-5p YWHAZ 0.230152919654905 0.0742909586754846 0.309265826104513 0.0711240023820104 miRanda -0.131980512724442 0.0468804731221123 NA NA NA hsa-miR-21-5p ZADH2 2.73773305747971 1.38864982139576e-43 -0.0946367983009928 0.521473360372585 miRNAWalker2_validate -0.125566153852395 0.000108759428042602 NA NA NA hsa-miR-28-5p ZBED1 0.230152919654905 0.0742909586754846 0.145047625989103 0.339987970277721 miRanda -0.137174908476747 0.0194969193668013 NA NA NA hsa-miR-330-5p ZBTB16 1.15100069700871 4.85551805046014e-07 -4.69496897387157 4.31130951508901e-16 miRanda -0.837052160676956 1.08033198541505e-11 NA NA NA hsa-miR-455-5p ZBTB16 2.2582442061694 1.43472128037398e-13 -4.69496897387157 4.31130951508901e-16 miRanda -0.677749532375596 4.07421651269384e-14 NA NA NA hsa-miR-542-3p ZBTB16 1.18832665895751 1.98700670691565e-07 -4.69496897387157 4.31130951508901e-16 miRanda -0.460506976292349 0.000245155497213058 NA NA NA hsa-miR-21-5p ZBTB20 2.73773305747971 1.38864982139576e-43 -1.43804710029372 8.52102753381236e-08 miRNAWalker2_validate -0.359305120335988 1.47463998121862e-09 NA NA NA hsa-miR-21-5p ZBTB38 2.73773305747971 1.38864982139576e-43 -0.801778771665242 8.8518449898149e-06 miRNAWalker2_validate -0.141723208961416 0.000426831359589776 NA NA NA hsa-miR-28-5p ZBTB43 0.230152919654905 0.0742909586754846 -0.362391796923031 0.0212368857731971 miRanda -0.153976874914252 0.0114746848069664 NA NA NA hsa-miR-21-5p ZBTB47 2.73773305747971 1.38864982139576e-43 -1.27249050834428 5.23741533445086e-13 miRNAWalker2_validate -0.219227745078011 3.14096681880308e-08 NA NA NA hsa-miR-21-5p ZBTB8A 2.73773305747971 1.38864982139576e-43 -0.311470536482052 0.00679367139385109 miRNAWalker2_validate -0.132252469608448 1.43318995277007e-07 NA NA NA hsa-miR-28-5p ZC3HAV1L 0.230152919654905 0.0742909586754846 0.758966376736812 0.0246291542454069 miRanda -0.300313567553811 0.0220999175590844 NA NA NA hsa-miR-15b-5p ZCCHC14 1.57112623124278 9.14247846750597e-13 -0.532573784551564 0.000117757486661172 miRNAWalker2_validate -0.107883037499621 0.000294412969849824 NA NA NA hsa-miR-28-5p ZDHHC14 0.230152919654905 0.0742909586754846 -0.420877670161361 0.0714978913519264 miRanda -0.212354716572132 0.019004499252291 NA NA NA hsa-miR-200a-3p ZEB1 4.59434485520731 6.38952518573476e-18 -2.59416392469398 4.19342616481451e-16 miRNAWalker2_validate;miRTarBase -0.369480725738631 7.14096237523422e-47 20473948;27402864;27402080;23743934;24815002;24424572;19854497;26887977;24390222;26242262;19544444;23626803;24037528 ZEB1 is also known to repress miR-200c-141 transcription in a negative feedback loop but otherwise little is known about the transcriptional regulation of the miR-200 family and miR-205;This circuit comprises the microRNA 200 miR-200 family ZEB1 and GRHL2;Conversely ectopic expression of miR-200 inhibited this sprouting by indirectly reducing the protein levels of PDGFRβ through the direct suppression of ZEB1;This finding was accompanied by a sharp downregulation in the expression of the miR-200 family of microRNAs well-known targets of ZEB1;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;GRHL2 miR 200 ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification;Inhibition of ZEB1 by miR 200 characterizes Helicobacter pylori positive gastric diffuse large B cell lymphoma with a less aggressive behavior; Through genome-wide expression profiles of both miRNAs and mRNAs in nine H pylori-positive and nine H pylori-negative gastric diffuse large B-cell lymphomas we identified inhibition of ZEB1 zinc-finger E-box-binding homeobox 1 by miR-200 in H pylori-positive gastric diffuse large B-cell lymphomas; In 30 H pylori-positive and 30 H pylori-negative gastric diffuse large B-cell lymphomas we confirmed that H pylori-positive gastric diffuse large B-cell lymphomas had higher levels of miR-200 by qRT-PCR and lower levels of ZEB1 and higher levels of BCL6 using immunohistochemistry;MiR 200 suppresses metastases of colorectal cancer through ZEB1; Here we showed that the levels of miR-200 were significantly decreased and the levels of ZEB1 were significantly increased in the CRC specimens from patients compared to the paired non-tumor tissue; Moreover the levels of miR-200 and ZEB1 are inversely correlated; Bioinformatics analyses showed that miR-200 targeted the 3'-UTR of ZEB1 mRNA to inhibit its translation which was confirmed by luciferase reporter assay;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;Concomitant with miR-200 decrease there was an increase in ZEB1 mRNA expression;MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways ;;;;;tumorigenesis;;;;metastasis;;;metastasis bladder cancer;sarcoma;breast cancer;endometrial cancer;sarcoma;head and neck cancer;ovarian cancer;ovarian cancer;B cell lymphoma;colorectal cancer;prostate cancer;breast cancer;breast cancer hsa-miR-200b-3p ZEB1 3.78235093249346 3.18343003239465e-14 -2.59416392469398 4.19342616481451e-16 miRNAWalker2_validate;miRTarBase -0.378793354992551 2.50614839227454e-41 20473948;24352645;27402864;27402080;23743934;24815002;24424572;26011542;19854497;26887977;24390222;27307751;26242262;19544444;23626803;26783187;24037528 ZEB1 is also known to repress miR-200c-141 transcription in a negative feedback loop but otherwise little is known about the transcriptional regulation of the miR-200 family and miR-205;Functional experiments demonstrated that miR-200b suppressed ZEB1 augmented E-cadherin inhibited cell migration and suppressed tumor growth in a mouse model;This circuit comprises the microRNA 200 miR-200 family ZEB1 and GRHL2;Conversely ectopic expression of miR-200 inhibited this sprouting by indirectly reducing the protein levels of PDGFRβ through the direct suppression of ZEB1;This finding was accompanied by a sharp downregulation in the expression of the miR-200 family of microRNAs well-known targets of ZEB1;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;Here we show that 53BP1 negatively regulated EMT by modulating ZEB1 through targeting microRNA miR-200b and miR-429; In 18 clinical tissue samples expression of 53BP1 was positively correlated with miR-200b and mir-429 and negatively correlated with ZEB1;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;GRHL2 miR 200 ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification;Inhibition of ZEB1 by miR 200 characterizes Helicobacter pylori positive gastric diffuse large B cell lymphoma with a less aggressive behavior; Through genome-wide expression profiles of both miRNAs and mRNAs in nine H pylori-positive and nine H pylori-negative gastric diffuse large B-cell lymphomas we identified inhibition of ZEB1 zinc-finger E-box-binding homeobox 1 by miR-200 in H pylori-positive gastric diffuse large B-cell lymphomas; In 30 H pylori-positive and 30 H pylori-negative gastric diffuse large B-cell lymphomas we confirmed that H pylori-positive gastric diffuse large B-cell lymphomas had higher levels of miR-200 by qRT-PCR and lower levels of ZEB1 and higher levels of BCL6 using immunohistochemistry;MicroRNA 200b acts as a tumor suppressor in osteosarcoma via targeting ZEB1; Moreover ZEB1 was identified as a target gene of miR-200b and its expression levels were negatively mediated by miR-200b in osteosarcoma cells; Based on these findings our study suggests that miR-200b inhibits the proliferation migration and invasion of osteosarcoma cells probably via the inhibition of ZEB1 expression;MiR 200 suppresses metastases of colorectal cancer through ZEB1; Here we showed that the levels of miR-200 were significantly decreased and the levels of ZEB1 were significantly increased in the CRC specimens from patients compared to the paired non-tumor tissue; Moreover the levels of miR-200 and ZEB1 are inversely correlated; Bioinformatics analyses showed that miR-200 targeted the 3'-UTR of ZEB1 mRNA to inhibit its translation which was confirmed by luciferase reporter assay;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;Concomitant with miR-200 decrease there was an increase in ZEB1 mRNA expression; Concomitant with the increase in miR-200b and miR-200c ZEB1 expression was decreased and cells appeared more epithelial in morphology and were sensitized to TAM and fulvestrant inhibition;Nintedanib was able to reverse TGF-β1-induced EMT and resistance to gefitinib caused by miR-200b and miR-141 upregulation and ZEB1 downregulation;MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways ;cell migration;;;;;tumorigenesis;;;;;;metastasis;;;drug resistance;metastasis bladder cancer;gastric cancer;sarcoma;breast cancer;endometrial cancer;sarcoma;head and neck cancer;breast cancer;ovarian cancer;ovarian cancer;B cell lymphoma;sarcoma;colorectal cancer;prostate cancer;breast cancer;lung squamous cell cancer;breast cancer hsa-miR-375 ZEB1 1.13910305294079 0.0512283522214186 -2.59416392469398 4.19342616481451e-16 miRanda -0.132116774288875 1.04195264306108e-06 27270433 A ZEB1 miR 375 YAP1 pathway regulates epithelial plasticity in prostate cancer; Furthermore transcription of the miR-375 gene was shown to be directly repressed by the EMT transcription factor ZEB1 prostate cancer hsa-miR-200a-3p ZEB2 4.59434485520731 6.38952518573476e-18 -2.26388876645177 1.13775147583663e-12 miRNAWalker2_validate;miRTarBase -0.406898897491553 4.99955187268944e-62 24518294;19787069;24815002;24424572;19854497;21529905;19544444;25797260 This switch involved activation of the transforming growth factor-β TGFβ signaling network that led to a shift in the balance between miR-200 microRNAs and the transcription factor zinc finger E-box-binding homeobox 2 ZEB2 resulting in suppressed transcription of the gene encoding E-cadherin;These findings are surprising since the miR-200 family was previously shown to promote epithelial characteristics by inhibiting the transcriptional repressor Zeb2 and thereby enhancing E-cadherin expression; Expression of miR-200 which promotes a mesenchymal to epithelial cell transition MET by inhibiting Zeb2 expression unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;MicroRNA 200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E cadherin repressor ZEB2; The 3'-UTR of ZEB2 mRNA a transcriptional repressor of E-cadherin was found to be regulated directly by miR-200a; Our results suggest that loss of expression of miR-200a may play a critical role in the repression of E-cadherin by ZEB2 thereby enhancing migration and invasion in CD133/1+ cells;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;MicroRNA 200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2; Overexpression of miR-200a in SP cells decreased metastasis-related markers and expression of ZEB2; The associations between miR-200a SP cells and ZEB2 were validated in HCC; These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2 ;metastasis;;tumorigenesis;;;;metastasis breast cancer;breast cancer;sarcoma;head and neck cancer;ovarian cancer;ovarian cancer;prostate cancer;liver cancer hsa-miR-200b-3p ZEB2 3.78235093249346 3.18343003239465e-14 -2.26388876645177 1.13775147583663e-12 miRNAWalker2_validate;miRTarBase -0.427769085329821 9.80718912583072e-58 24518294;19787069;24815002;24424572;24769353;19854497;22311119;19544444 This switch involved activation of the transforming growth factor-β TGFβ signaling network that led to a shift in the balance between miR-200 microRNAs and the transcription factor zinc finger E-box-binding homeobox 2 ZEB2 resulting in suppressed transcription of the gene encoding E-cadherin;These findings are surprising since the miR-200 family was previously shown to promote epithelial characteristics by inhibiting the transcriptional repressor Zeb2 and thereby enhancing E-cadherin expression; Expression of miR-200 which promotes a mesenchymal to epithelial cell transition MET by inhibiting Zeb2 expression unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;Zinc finger E box binding homeobox 2 ZEB2 regulated by miR 200b contributes to multi drug resistance of small cell lung cancer; In silico analysis demonstrated that there are complementary binding sites between miR-200b and ZEB2 3'-UTR and identified miR-200b as a potential regulator of ZEB2; Overexpression of miR-200b led to the downregulation of ZEB2 at protein level; Luciferase reporter gene assay showed that 3'UTR ZEB2 activity was regulated by miR-200b; Our results suggest that ZEB2 modulates drug resistance and is regulated by miR-200b;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;MicroRNA 200b regulates cell proliferation invasion and migration by directly targeting ZEB2 in gastric carcinoma; There was a strong correlation between the levels of miR-200b and ZEB2 and E-cadherin mRNAs in gastric cancer patients; miR-200b regulates ZEB2 expression and thus controls metastasis in gastric cancer;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2 ;metastasis;;tumorigenesis;drug resistance;;metastasis; breast cancer;breast cancer;sarcoma;head and neck cancer;lung squamous cell cancer;ovarian cancer;gastric cancer;prostate cancer hsa-miR-28-5p ZEB2 0.230152919654905 0.0742909586754846 -2.26388876645177 1.13775147583663e-12 miRanda -0.253663284279593 0.0459230522262504 NA NA NA hsa-miR-375 ZEB2 1.13910305294079 0.0512283522214186 -2.26388876645177 1.13775147583663e-12 miRanda -0.131046090320219 9.64864747256491e-07 NA NA NA hsa-miR-28-5p ZFAT 0.230152919654905 0.0742909586754846 0.145182185606273 0.277541599696215 miRanda -0.121553543816229 0.0184845567952556 NA NA NA hsa-miR-183-5p ZFHX4 4.19757025992371 4.79612296318304e-26 -2.72243653694716 1.46650038380412e-06 miRNAWalker2_validate -0.582362464159458 1.07729988594945e-20 NA NA NA hsa-miR-200a-3p ZFPM2 4.59434485520731 6.38952518573476e-18 -3.29884457958359 4.34537841593148e-12 miRNAWalker2_validate;miRTarBase -0.515931689623812 8.55862625857276e-41 26314828 It was reported that miR-200 can activate PI3K/AKT by targeting FOG2 friend of GATA 2 which directly binds to the p85α regulatory subunit of PI3K lung cancer hsa-miR-200b-3p ZFPM2 3.78235093249346 3.18343003239465e-14 -3.29884457958359 4.34537841593148e-12 miRNAWalker2_validate;miRTarBase -0.509319587386137 3.80043047137258e-33 26314828 It was reported that miR-200 can activate PI3K/AKT by targeting FOG2 friend of GATA 2 which directly binds to the p85α regulatory subunit of PI3K lung cancer hsa-miR-375 ZFPM2 1.13910305294079 0.0512283522214186 -3.29884457958359 4.34537841593148e-12 miRanda -0.190581805209332 1.91933746049352e-06 NA NA NA hsa-miR-484 ZFX 1.81844463411787 1.82951571230938e-15 -0.669612471575411 7.47870575363928e-05 miRNAWalker2_validate -0.183137002860081 1.13262412127412e-07 NA NA NA hsa-miR-21-5p ZFYVE16 2.73773305747971 1.38864982139576e-43 -0.334209102997813 0.0108732777592955 miRNAWalker2_validate -0.145013576555871 4.50528195526375e-07 NA NA NA hsa-miR-484 ZFYVE21 1.81844463411787 1.82951571230938e-15 -0.485183256175152 0.000233026323542383 miRNAWalker2_validate -0.120165002030842 8.34571624885548e-06 NA NA NA hsa-miR-28-5p ZFYVE26 0.230152919654905 0.0742909586754846 -0.0616824288558266 0.683596534905304 miRanda -0.309309807068331 8.04639352960842e-08 NA NA NA hsa-miR-28-5p ZIC5 0.230152919654905 0.0742909586754846 2.59928132040429 0.000494910451581881 miRanda -1.33773395224101 3.54013847485892e-06 NA NA NA hsa-miR-21-5p ZMYM2 2.73773305747971 1.38864982139576e-43 0.239197935609045 0.147272959332338 miRNAWalker2_validate -0.145922802154255 5.86820165400074e-05 NA NA NA hsa-miR-21-5p ZNF217 2.73773305747971 1.38864982139576e-43 0.304361345363533 0.118432127591969 miRNAWalker2_validate -0.158158645716432 0.000235450034338374 NA NA NA hsa-miR-155-5p ZNF248 1.20164021433135 0.00086170622431261 -0.282718198143071 0.0898849986662924 miRNAWalker2_validate -0.206812231552264 1.06743996035976e-22 NA NA NA hsa-miR-155-5p ZNF254 1.20164021433135 0.00086170622431261 0.61602161454507 0.0345981485228563 miRNAWalker2_validate -0.2556856393699 1.95588740854008e-11 NA NA NA hsa-miR-21-5p ZNF292 2.73773305747971 1.38864982139576e-43 -0.195609944153402 0.298981401407483 miRNAWalker2_validate -0.23363971083263 1.26184637735763e-08 NA NA NA hsa-miR-28-5p ZNF407 0.230152919654905 0.0742909586754846 -0.57279545105749 3.85831436986441e-06 miRanda -0.170422531890986 0.000406316852285246 NA NA NA hsa-miR-28-5p ZNF410 0.230152919654905 0.0742909586754846 -0.141750428354367 0.113072413140833 miRanda -0.205709717336686 1.03484272658024e-09 NA NA NA hsa-miR-28-5p ZNF483 0.230152919654905 0.0742909586754846 -1.72005210223492 1.64336415566414e-08 miRanda -0.389864778662496 0.00114130838204644 NA NA NA hsa-miR-155-5p ZNF493 1.20164021433135 0.00086170622431261 0.0114728204247427 0.968946773140878 miRNAWalker2_validate -0.217733182025234 1.88267933515264e-08 NA NA NA hsa-miR-155-5p ZNF561 1.20164021433135 0.00086170622431261 -0.228738904379719 0.176955580772831 miRNAWalker2_validate -0.192320107735567 6.1572147942568e-19 NA NA NA hsa-miR-155-5p ZNF611 1.20164021433135 0.00086170622431261 0.145030335613324 0.469930402917237 miRNAWalker2_validate -0.137469535051594 1.9595827838214e-07 NA NA NA hsa-miR-155-5p ZNF652 1.20164021433135 0.00086170622431261 -0.141352517152979 0.298747959072066 miRNAWalker2_validate;miRTarBase -0.181037419594696 1.72620184876107e-26 22797073 A search for cancer-related target genes of miR-155 revealed ZNF652 a novel zinc-finger transcriptional repressor breast cancer hsa-miR-21-5p ZNF667 2.73773305747971 1.38864982139576e-43 -1.62789664920691 0.00553368911884831 miRNAWalker2_validate -0.496986344613896 0.000132682883727731 NA NA NA hsa-miR-196a-5p ZNF763 1.52993069622497 0.00397268663639603 -0.115802317753036 0.692155194158141 miRNAWalker2_validate -0.159416997180026 8.9036790648781e-10 NA NA NA hsa-miR-155-5p ZNF83 1.20164021433135 0.00086170622431261 0.506779593674497 0.0389426117123832 miRNAWalker2_validate -0.209550092276403 6.76721403633013e-11 NA NA NA hsa-miR-21-5p ZRANB1 2.73773305747971 1.38864982139576e-43 -0.772048409987169 1.16896161952567e-12 miRNAWalker2_validate -0.204577107510071 5.37724477833108e-18 NA NA NA hsa-miR-92b-3p ZSCAN18 1.20409245530001 3.41055816361655e-06 -1.31121542968169 0.00102279051525484 miRNAWalker2_validate -0.4230752025856 7.69323759373034e-09 NA NA NA hsa-miR-21-5p ZYG11B 2.73773305747971 1.38864982139576e-43 -0.398417232369114 0.00206940926401373 miRNAWalker2_validate -0.216921618843246 5.93380539258308e-15 NA NA NA