miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-3p ABI3BP 0.0966652362351867 0.423761916840503 -2.62627427248809 9.68454065806291e-15 miRNATAP -0.644179584333113 2.81242105702785e-07 NA NA NA hsa-miR-320a ABI3BP 0.801356001806321 4.91397101474502e-09 -2.62627427248809 9.68454065806291e-15 miRanda -0.36313317177472 0.000910242744365061 NA NA NA hsa-miR-320b ABI3BP 1.23473838180754 3.04337566045537e-14 -2.62627427248809 9.68454065806291e-15 miRanda -0.259772059094725 0.00439343874606529 NA NA NA hsa-miR-455-5p ABI3BP 1.408595672323 5.52039116456697e-22 -2.62627427248809 9.68454065806291e-15 miRanda -0.965200600516068 5.49314434274662e-24 NA NA NA hsa-miR-505-5p ABI3BP 1.25888458076414 7.80089782306577e-13 -2.62627427248809 9.68454065806291e-15 miRNATAP -0.432427123575778 2.48051688934079e-07 NA NA NA hsa-miR-576-5p ABI3BP 0.940432050128373 6.90227595663302e-12 -2.62627427248809 9.68454065806291e-15 PITA -0.846406015786159 1.44363052364112e-15 NA NA NA hsa-miR-590-5p ABI3BP 0.763025362395968 3.65305892505623e-09 -2.62627427248809 9.68454065806291e-15 miRanda -0.927752591866096 2.13920593884865e-16 NA NA NA hsa-miR-92a-3p ABI3BP 0.994679542307232 1.32587679156217e-16 -2.62627427248809 9.68454065806291e-15 miRNATAP -1.18285622789903 1.05689475150444e-23 NA NA NA hsa-miR-205-3p ACTA2 1.2960640797621 5.80786479909147e-11 -0.105146391883932 0.618780417530016 MirTarget -0.503031651194857 9.92305587196631e-32 NA NA NA hsa-miR-484 ACTA2 0.918280909791707 1.39168306854263e-14 -0.105146391883932 0.618780417530016 miRNAWalker2_validate -0.454042844857468 1.06201768885571e-09 NA NA NA hsa-miR-139-5p ADAM12 -1.46099200329485 7.85040381494472e-22 3.77832293743406 8.72835569342358e-40 miRanda -0.595272578806011 1.08012151003931e-12 NA NA NA hsa-miR-19a-3p ADAM12 1.35800152353624 2.80940447111944e-12 3.77832293743406 8.72835569342358e-40 miRNATAP -0.209915889479845 0.00201334301649146 NA NA NA hsa-miR-19b-3p ADAM12 0.538732279378089 0.000622008277870679 3.77832293743406 8.72835569342358e-40 miRNATAP -0.467523087084292 3.39528236758114e-08 NA NA NA hsa-miR-205-3p ADAM12 1.2960640797621 5.80786479909147e-11 3.77832293743406 8.72835569342358e-40 mirMAP -0.237854745405468 0.000372205212606547 NA NA NA hsa-miR-20b-5p ADAM12 0.345967670847176 0.232014828043601 3.77832293743406 8.72835569342358e-40 mirMAP -0.181316484146734 9.68250238443357e-05 NA NA NA hsa-miR-217 ADAM12 -1.35391381055929 2.42394951427902e-09 3.77832293743406 8.72835569342358e-40 miRanda -0.187318402526754 0.00136780627336104 NA NA NA hsa-miR-26a-5p ADAM12 -1.09269574587169 1.24020612216319e-22 3.77832293743406 8.72835569342358e-40 mirMAP;miRNATAP -0.463211159153228 6.70266100513515e-05 NA NA NA hsa-miR-26b-5p ADAM12 -0.254478038884324 0.0285227763044636 3.77832293743406 8.72835569342358e-40 mirMAP;miRNATAP -0.74002500735774 1.25730268975361e-10 NA NA NA hsa-miR-29a-3p ADAM12 -1.26881270980079 2.82496991513463e-22 3.77832293743406 8.72835569342358e-40 miRNATAP -0.694839058262802 9.74520645017673e-13 25886595 ADAM12 L is a direct target of the miR 29 and miR 200 families in breast cancer breast cancer hsa-miR-29a-5p ADAM12 0.323252792625584 0.0370417231222825 3.77832293743406 8.72835569342358e-40 mirMAP -0.246393066266478 0.0047540927945701 25886595 ADAM12 L is a direct target of the miR 29 and miR 200 families in breast cancer breast cancer hsa-miR-29b-3p ADAM12 -0.110721443686039 0.511264554091106 3.77832293743406 8.72835569342358e-40 miRNAWalker2_validate;miRTarBase;miRNATAP -0.595649398334362 3.18907843634056e-14 25886595 ADAM12 L is a direct target of the miR 29 and miR 200 families in breast cancer breast cancer hsa-miR-29c-3p ADAM12 -2.08166260448948 8.3238369390898e-24 3.77832293743406 8.72835569342358e-40 miRNATAP -0.520766743355713 6.60572989024021e-18 NA NA NA hsa-miR-338-3p ADAM12 -0.948755228846395 8.99167125682392e-08 3.77832293743406 8.72835569342358e-40 miRanda -0.570942114299586 7.40480302927661e-15 NA NA NA hsa-miR-33a-3p ADAM12 0.20371038027126 0.212335697664505 3.77832293743406 8.72835569342358e-40 mirMAP -0.328588853626055 8.85990361985774e-05 NA NA NA hsa-miR-3607-3p ADAM12 1.01377165357363 9.13355519701165e-05 3.77832293743406 8.72835569342358e-40 mirMAP;miRNATAP -0.143922389930594 0.00548281806764609 NA NA NA hsa-miR-374a-5p ADAM12 -0.621903385111545 6.61791773205282e-12 3.77832293743406 8.72835569342358e-40 mirMAP -0.708402423392906 1.38381466257049e-06 NA NA NA hsa-miR-374b-5p ADAM12 -0.288413933608091 0.0041474558664058 3.77832293743406 8.72835569342358e-40 mirMAP -0.483180361115651 0.000341462450886248 NA NA NA hsa-miR-429 ADAM12 0.559451508722375 0.00563641638673083 3.77832293743406 8.72835569342358e-40 miRanda;miRNATAP -0.408670120328878 5.02672043365445e-10 NA NA NA hsa-miR-582-3p ADAM12 -0.248056267546012 0.143798829508405 3.77832293743406 8.72835569342358e-40 mirMAP -0.425272005284199 7.15640636789031e-08 NA NA NA hsa-miR-582-5p ADAM12 -0.0366995972742474 0.821827119138923 3.77832293743406 8.72835569342358e-40 miRNATAP -0.449223772269611 4.77251885562101e-08 NA NA NA hsa-miR-590-3p ADAM12 0.221436901462551 0.0965904764063157 3.77832293743406 8.72835569342358e-40 mirMAP -0.297316311507829 0.00348043686989717 NA NA NA hsa-miR-16-5p ANPEP 0.521122945828175 1.40561786410572e-06 0.310977681946924 0.101822554874403 miRNAWalker2_validate -0.360077864971847 2.14420623913885e-06 NA NA NA hsa-miR-96-5p ANPEP 1.42326703011157 4.39736150032373e-14 0.310977681946924 0.101822554874403 mirMAP -0.191055687200569 7.214382352581e-06 NA NA NA hsa-miR-107 AREG -0.0447040564279497 0.671618791096755 0.418478955882987 0.221785826717941 miRanda -0.614866971292197 1.52185825241937e-05 NA NA NA hsa-miR-129-5p AREG -0.246329588499478 0.436451191224681 0.418478955882987 0.221785826717941 miRanda -0.134467655864913 0.00495139961450085 NA NA NA hsa-miR-217 AREG -1.35391381055929 2.42394951427902e-09 0.418478955882987 0.221785826717941 miRanda -0.232960701833644 0.000306828711226382 NA NA NA hsa-miR-326 AREG -0.425943992128769 0.0415010315530797 0.418478955882987 0.221785826717941 miRanda -0.259711813737398 0.000278969391218594 NA NA NA hsa-miR-335-5p AREG -1.17227779671552 1.49282618530733e-10 0.418478955882987 0.221785826717941 miRNAWalker2_validate -0.414177610610323 1.82148425773746e-07 NA NA NA hsa-miR-107 BASP1 -0.0447040564279497 0.671618791096755 1.34904758102411 6.57977539391262e-09 miRanda -0.338071056827964 0.000582687908439235 NA NA NA hsa-miR-129-5p BASP1 -0.246329588499478 0.436451191224681 1.34904758102411 6.57977539391262e-09 miRanda -0.120961301419496 0.000235205615826579 NA NA NA hsa-miR-200b-3p BASP1 0.0717138787925347 0.682858087587209 1.34904758102411 6.57977539391262e-09 TargetScan -0.544190100024545 5.04106897673576e-22 NA NA NA hsa-miR-200c-3p BASP1 0.630251054099546 0.000131975031451555 1.34904758102411 6.57977539391262e-09 miRNATAP -0.291845967420149 2.23886424567974e-06 NA NA NA hsa-miR-320b BASP1 1.23473838180754 3.04337566045537e-14 1.34904758102411 6.57977539391262e-09 PITA;miRanda -0.209458659934333 0.000678627707011984 NA NA NA hsa-miR-33a-3p BASP1 0.20371038027126 0.212335697664505 1.34904758102411 6.57977539391262e-09 miRNATAP -0.311210855671213 9.72048111853918e-07 NA NA NA hsa-miR-429 BASP1 0.559451508722375 0.00563641638673083 1.34904758102411 6.57977539391262e-09 PITA;miRanda;miRNATAP -0.341904671141592 6.8113346900678e-12 NA NA NA hsa-miR-532-3p BASP1 0.80240056676907 1.08989551712617e-09 1.34904758102411 6.57977539391262e-09 PITA -0.212635912928358 0.00587504760460831 NA NA NA hsa-miR-96-5p BASP1 1.42326703011157 4.39736150032373e-14 1.34904758102411 6.57977539391262e-09 TargetScan -0.200609809728809 0.000154700046101178 NA NA NA hsa-let-7b-3p BDNF 0.120166961637302 0.299224004314356 0.0408778714112631 0.883450816679916 MirTarget;miRNATAP -0.485153955582307 3.78595524866656e-06 NA NA NA hsa-miR-142-5p BDNF 0.288897753038094 0.0900009317815725 0.0408778714112631 0.883450816679916 mirMAP -0.308543354723933 1.36682819592341e-05 NA NA NA hsa-miR-146b-5p BDNF 0.917975986853978 3.33749259316025e-09 0.0408778714112631 0.883450816679916 miRanda -0.295426001779662 0.000122805573761243 NA NA NA hsa-miR-155-5p BDNF 0.533437622040649 0.00248671179205372 0.0408778714112631 0.883450816679916 miRNATAP -0.22678558150571 0.000944767256917019 NA NA NA hsa-miR-22-3p BDNF 0.00776313533473072 0.926356548861307 0.0408778714112631 0.883450816679916 miRNAWalker2_validate;miRTarBase -0.427506450899018 0.00361347435585047 NA NA NA hsa-miR-29b-1-5p BDNF 1.39669186711325 4.36960953138935e-11 0.0408778714112631 0.883450816679916 mirMAP -0.226952768941406 5.14949172622145e-05 NA NA NA hsa-miR-338-5p BDNF -1.71946558699173 2.62649071488641e-23 0.0408778714112631 0.883450816679916 miRNATAP -0.232361738096582 0.000529367225285524 NA NA NA hsa-miR-365a-3p BDNF 0.446833934952926 0.00233857759218299 0.0408778714112631 0.883450816679916 miRNATAP -0.31502366808888 0.000131395532237701 NA NA NA hsa-miR-424-5p BDNF 1.48125289532143 9.10372985713165e-19 0.0408778714112631 0.883450816679916 MirTarget;miRNATAP -0.283162731321444 4.92699422656507e-05 NA NA NA hsa-miR-30b-3p BGN -0.338530747940815 0.0223424741180399 1.63937708165962 2.52796976227233e-12 mirMAP -0.401804932986291 8.55904520936043e-09 NA NA NA hsa-miR-486-5p BGN -1.70341092285685 6.64232609099498e-14 1.63937708165962 2.52796976227233e-12 miRanda -0.177372643874488 6.84462965299382e-05 NA NA NA hsa-miR-125b-5p BMP1 -0.993460109818276 5.07736727659894e-12 1.72201156783236 1.20984618133555e-36 mirMAP -0.165523082142142 0.000136294571322451 NA NA NA hsa-miR-139-3p BMP1 -2.34149852749586 1.53240079104425e-34 1.72201156783236 1.20984618133555e-36 miRNATAP -0.168068517608846 5.20413422206654e-08 NA NA NA hsa-miR-139-5p BMP1 -1.46099200329485 7.85040381494472e-22 1.72201156783236 1.20984618133555e-36 miRanda -0.150776059706394 0.000174690400352082 NA NA NA hsa-miR-140-5p BMP1 -0.412389003031485 0.000136051708543369 1.72201156783236 1.20984618133555e-36 miRanda -0.156859036296479 0.00803462271336929 NA NA NA hsa-miR-27b-3p BMP1 -0.732682718863563 2.26896143573324e-09 1.72201156783236 1.20984618133555e-36 mirMAP -0.387069605207269 1.36230950303058e-14 NA NA NA hsa-miR-29a-3p BMP1 -1.26881270980079 2.82496991513463e-22 1.72201156783236 1.20984618133555e-36 miRNATAP -0.293395936651713 2.19554461485418e-10 NA NA NA hsa-miR-29b-3p BMP1 -0.110721443686039 0.511264554091106 1.72201156783236 1.20984618133555e-36 miRNAWalker2_validate;miRTarBase;miRNATAP -0.129092753511331 0.000653586895619419 NA NA NA hsa-miR-29c-3p BMP1 -2.08166260448948 8.3238369390898e-24 1.72201156783236 1.20984618133555e-36 miRNATAP -0.307317110942567 3.37821097850339e-28 NA NA NA hsa-miR-30b-3p BMP1 -0.338530747940815 0.0223424741180399 1.72201156783236 1.20984618133555e-36 miRNATAP -0.265083767255218 4.79180027905713e-10 NA NA NA hsa-miR-335-5p BMP1 -1.17227779671552 1.49282618530733e-10 1.72201156783236 1.20984618133555e-36 miRNAWalker2_validate -0.189628860376179 2.17834447517948e-08 NA NA NA hsa-miR-34a-5p BMP1 -0.117372471043915 0.364001947180738 1.72201156783236 1.20984618133555e-36 mirMAP -0.159415965420147 0.00129559701423948 NA NA NA hsa-miR-429 BMP1 0.559451508722375 0.00563641638673083 1.72201156783236 1.20984618133555e-36 miRNATAP -0.129355407593307 3.70298392448493e-05 NA NA NA hsa-miR-141-3p CADM1 0.730011517758706 0.000120338355004032 -1.3222982787043 1.17768528464379e-07 MirTarget;TargetScan -0.226465179319997 8.16553857030758e-05 NA NA NA hsa-miR-15a-5p CADM1 0.783550182002274 2.60699595655907e-11 -1.3222982787043 1.17768528464379e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.523194169610344 1.00934695369889e-08 NA NA NA hsa-miR-15b-5p CADM1 0.85315666454713 3.79816274836297e-12 -1.3222982787043 1.17768528464379e-07 miRNATAP -0.282623573148087 0.00133246256013992 NA NA NA hsa-miR-16-5p CADM1 0.521122945828175 1.40561786410572e-06 -1.3222982787043 1.17768528464379e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.327550873385916 0.0012662929486335 NA NA NA hsa-miR-193a-3p CADM1 0.22120710726779 0.111827069464729 -1.3222982787043 1.17768528464379e-07 MirTarget;PITA;miRanda;miRNATAP -0.438637882728817 2.35627800542293e-08 NA NA NA hsa-miR-193b-3p CADM1 1.72788400801602 3.0722151264559e-21 -1.3222982787043 1.17768528464379e-07 MirTarget -0.541594214307215 1.97551424744578e-22 NA NA NA hsa-miR-1976 CADM1 0.638808083289405 2.94840228896364e-07 -1.3222982787043 1.17768528464379e-07 MirTarget -0.402634722033058 3.95700465301252e-06 NA NA NA hsa-miR-200a-3p CADM1 0.607140814457753 0.00289840524858752 -1.3222982787043 1.17768528464379e-07 MirTarget -0.149731372208326 0.00543500923035729 NA NA NA hsa-miR-205-5p CADM1 1.50759485376634 2.0003886738248e-16 -1.3222982787043 1.17768528464379e-07 MirTarget;miRNATAP -0.506578754431743 2.31088489087969e-19 NA NA NA hsa-miR-224-3p CADM1 0.502645536188015 0.0081142387260641 -1.3222982787043 1.17768528464379e-07 MirTarget -0.228162867976923 8.63385507355983e-05 NA NA NA hsa-miR-23a-3p CADM1 0.348231698801568 6.4911858506572e-05 -1.3222982787043 1.17768528464379e-07 miRNATAP -0.470504572244051 0.000209061209445837 NA NA NA hsa-miR-27a-3p CADM1 0.348456440505425 0.00126682892514312 -1.3222982787043 1.17768528464379e-07 MirTarget;miRNATAP -0.562554036456875 2.69411616793198e-08 NA NA NA hsa-miR-31-3p CADM1 2.10124531535908 1.70135756565194e-08 -1.3222982787043 1.17768528464379e-07 MirTarget;miRNATAP -0.238238592965303 3.43971659432345e-17 NA NA NA hsa-miR-424-5p CADM1 1.48125289532143 9.10372985713165e-19 -1.3222982787043 1.17768528464379e-07 miRNATAP -0.322970168530773 2.93898600625187e-07 NA NA NA hsa-miR-429 CADM1 0.559451508722375 0.00563641638673083 -1.3222982787043 1.17768528464379e-07 miRNATAP -0.152462915118437 0.00503459208119488 NA NA NA hsa-miR-455-5p CADM1 1.408595672323 5.52039116456697e-22 -1.3222982787043 1.17768528464379e-07 miRanda -0.579704160541406 1.77630907531324e-16 NA NA NA hsa-miR-484 CADM1 0.918280909791707 1.39168306854263e-14 -1.3222982787043 1.17768528464379e-07 miRNAWalker2_validate -0.276810947303668 0.0021754892135625 NA NA NA hsa-miR-505-3p CADM1 0.912823669571645 4.0549774967148e-13 -1.3222982787043 1.17768528464379e-07 MirTarget -0.299092753808196 0.000482609666151779 NA NA NA hsa-miR-590-5p CADM1 0.763025362395968 3.65305892505623e-09 -1.3222982787043 1.17768528464379e-07 PITA;miRanda;miRNATAP -0.487354256495006 4.62613872511382e-09 NA NA NA hsa-miR-92a-3p CADM1 0.994679542307232 1.32587679156217e-16 -1.3222982787043 1.17768528464379e-07 miRNATAP -0.484639993858509 4.07425204934439e-08 NA NA NA hsa-miR-96-5p CADM1 1.42326703011157 4.39736150032373e-14 -1.3222982787043 1.17768528464379e-07 TargetScan;miRNATAP -0.205704585595309 0.000293352890695828 NA NA NA hsa-let-7g-5p CALD1 -0.250780249469264 0.00939610188330072 0.871857616743083 1.46334094017319e-07 miRNATAP -0.291202904904948 0.000130707791869004 NA NA NA hsa-miR-106a-5p CALD1 0.67978010057847 0.00221925869726092 0.871857616743083 1.46334094017319e-07 miRNATAP -0.252522615804148 2.63302339359272e-15 NA NA NA hsa-miR-106b-5p CALD1 0.50378717276868 1.45412404526866e-05 0.871857616743083 1.46334094017319e-07 miRNATAP -0.395556233204301 1.59433828619292e-10 NA NA NA hsa-miR-126-5p CALD1 -0.953529188793816 7.91719143295591e-16 0.871857616743083 1.46334094017319e-07 mirMAP -0.232972830881834 0.000106185122342782 NA NA NA hsa-miR-142-3p CALD1 1.12754191614028 1.68798138028946e-08 0.871857616743083 1.46334094017319e-07 miRanda -0.157453033740612 1.14039150447872e-05 NA NA NA hsa-miR-142-5p CALD1 0.288897753038094 0.0900009317815725 0.871857616743083 1.46334094017319e-07 PITA;mirMAP -0.168958479899065 7.86438383010242e-05 NA NA NA hsa-miR-149-5p CALD1 0.443278770827687 0.0642022866136881 0.871857616743083 1.46334094017319e-07 miRNAWalker2_validate -0.25595083819881 4.37884551325195e-18 NA NA NA hsa-miR-15a-5p CALD1 0.783550182002274 2.60699595655907e-11 0.871857616743083 1.46334094017319e-07 miRNAWalker2_validate -0.277806958640319 5.2026449352298e-06 NA NA NA hsa-miR-16-2-3p CALD1 1.1567130855258 1.01867256952189e-14 0.871857616743083 1.46334094017319e-07 mirMAP -0.39952506696271 5.46348754099095e-18 NA NA NA hsa-miR-17-5p CALD1 1.41924888736771 2.75805544953758e-18 0.871857616743083 1.46334094017319e-07 TargetScan;miRNATAP -0.202592712947665 2.69168576063212e-06 NA NA NA hsa-miR-182-5p CALD1 1.15060905311096 6.25565852529946e-10 0.871857616743083 1.46334094017319e-07 MirTarget -0.113505400339691 0.00330602672524807 NA NA NA hsa-miR-20a-5p CALD1 1.1531986665452 1.02385132917958e-11 0.871857616743083 1.46334094017319e-07 miRNATAP -0.239347747710546 1.02596299879479e-08 NA NA NA hsa-miR-20b-5p CALD1 0.345967670847176 0.232014828043601 0.871857616743083 1.46334094017319e-07 miRNATAP -0.214802099296375 1.49917920695498e-18 NA NA NA hsa-miR-23b-5p CALD1 0.141208007066527 0.420202986869364 0.871857616743083 1.46334094017319e-07 miRNATAP -0.296327930935437 2.40353599074708e-12 NA NA NA hsa-miR-24-1-5p CALD1 -0.0503110566834755 0.742860080224713 0.871857616743083 1.46334094017319e-07 MirTarget -0.341239367795983 3.13482888406034e-13 NA NA NA hsa-miR-27b-3p CALD1 -0.732682718863563 2.26896143573324e-09 0.871857616743083 1.46334094017319e-07 miRNATAP -0.527144703438068 1.91153707222046e-20 NA NA NA hsa-miR-320a CALD1 0.801356001806321 4.91397101474502e-09 0.871857616743083 1.46334094017319e-07 PITA;miRanda;miRNATAP -0.183932404681941 0.00047700694961322 NA NA NA hsa-miR-320b CALD1 1.23473838180754 3.04337566045537e-14 0.871857616743083 1.46334094017319e-07 PITA;miRanda;miRNATAP -0.150255682794271 0.000603980266389457 NA NA NA hsa-miR-338-3p CALD1 -0.948755228846395 8.99167125682392e-08 0.871857616743083 1.46334094017319e-07 miRanda -0.16979495361931 2.80429775056271e-05 NA NA NA hsa-miR-34a-5p CALD1 -0.117372471043915 0.364001947180738 0.871857616743083 1.46334094017319e-07 miRNAWalker2_validate -0.387989503370713 3.44496132426478e-12 NA NA NA hsa-miR-361-5p CALD1 0.0803683277369505 0.314043140368058 0.871857616743083 1.46334094017319e-07 miRanda;miRNATAP -0.317576841213655 0.000645283622303847 NA NA NA hsa-miR-374a-3p CALD1 -0.299190081500425 0.00682975596757891 0.871857616743083 1.46334094017319e-07 miRNATAP -0.240646242850274 0.000281659821053154 NA NA NA hsa-miR-374a-5p CALD1 -0.621903385111545 6.61791773205282e-12 0.871857616743083 1.46334094017319e-07 mirMAP -0.328917480955727 3.62375812415805e-05 NA NA NA hsa-miR-374b-5p CALD1 -0.288413933608091 0.0041474558664058 0.871857616743083 1.46334094017319e-07 mirMAP -0.331985436050678 4.97890539993564e-06 NA NA NA hsa-miR-429 CALD1 0.559451508722375 0.00563641638673083 0.871857616743083 1.46334094017319e-07 miRanda -0.379687788422377 1.13734712173366e-28 NA NA NA hsa-miR-501-3p CALD1 0.820141346319976 1.74562930463389e-08 0.871857616743083 1.46334094017319e-07 TargetScan;miRNATAP -0.162672212805692 0.0010551428556358 NA NA NA hsa-miR-590-3p CALD1 0.221436901462551 0.0965904764063157 0.871857616743083 1.46334094017319e-07 miRanda;mirMAP -0.220915150764515 5.64496719697897e-05 NA NA NA hsa-miR-590-5p CALD1 0.763025362395968 3.65305892505623e-09 0.871857616743083 1.46334094017319e-07 miRanda -0.323301085702728 4.74081724527234e-09 NA NA NA hsa-miR-93-5p CALD1 1.61042951896619 5.1280369606967e-24 0.871857616743083 1.46334094017319e-07 miRNATAP -0.236518043163317 5.08025788760211e-08 NA NA NA hsa-miR-126-5p CALU -0.953529188793816 7.91719143295591e-16 0.939905146742839 1.91517392012572e-14 MirTarget -0.133752600085874 0.00311555786329751 NA NA NA hsa-miR-141-3p CALU 0.730011517758706 0.000120338355004032 0.939905146742839 1.91517392012572e-14 TargetScan -0.220093831045541 4.0069091149671e-15 NA NA NA hsa-miR-142-3p CALU 1.12754191614028 1.68798138028946e-08 0.939905146742839 1.91517392012572e-14 miRanda -0.124468410461311 3.70439898110345e-06 NA NA NA hsa-miR-150-5p CALU -0.243749814009231 0.331546276920338 0.939905146742839 1.91517392012572e-14 MirTarget -0.123337928411537 1.11564330176926e-08 NA NA NA hsa-miR-155-5p CALU 0.533437622040649 0.00248671179205372 0.939905146742839 1.91517392012572e-14 miRNAWalker2_validate -0.176126558903476 9.38324837837677e-09 NA NA NA hsa-miR-15a-5p CALU 0.783550182002274 2.60699595655907e-11 0.939905146742839 1.91517392012572e-14 MirTarget -0.256723845525148 1.70143563759176e-08 NA NA NA hsa-miR-15b-5p CALU 0.85315666454713 3.79816274836297e-12 0.939905146742839 1.91517392012572e-14 MirTarget -0.116555936658531 0.00799909430496661 NA NA NA hsa-miR-16-1-3p CALU 0.955017760172879 5.95379292601146e-11 0.939905146742839 1.91517392012572e-14 mirMAP -0.177437381945077 1.42020668893895e-06 NA NA NA hsa-miR-16-5p CALU 0.521122945828175 1.40561786410572e-06 0.939905146742839 1.91517392012572e-14 miRNAWalker2_validate;MirTarget -0.199809917645998 7.59530151647506e-05 NA NA NA hsa-miR-181c-5p CALU -0.168991199007857 0.196949106150297 0.939905146742839 1.91517392012572e-14 mirMAP -0.155179707786104 0.000218246313239026 NA NA NA hsa-miR-200b-3p CALU 0.0717138787925347 0.682858087587209 0.939905146742839 1.91517392012572e-14 MirTarget;TargetScan -0.285985306733678 2.29360887492896e-21 NA NA NA hsa-miR-200c-3p CALU 0.630251054099546 0.000131975031451555 0.939905146742839 1.91517392012572e-14 MirTarget -0.182230784646141 2.70344502745239e-08 NA NA NA hsa-miR-205-3p CALU 1.2960640797621 5.80786479909147e-11 0.939905146742839 1.91517392012572e-14 mirMAP -0.137915099914485 3.14207206447461e-07 NA NA NA hsa-miR-205-5p CALU 1.50759485376634 2.0003886738248e-16 0.939905146742839 1.91517392012572e-14 MirTarget -0.138971741680566 1.42591044963188e-06 NA NA NA hsa-miR-23b-3p CALU -0.497563803223134 3.31483353357535e-05 0.939905146742839 1.91517392012572e-14 mirMAP -0.176526068310272 0.000106681370867836 NA NA NA hsa-miR-29a-3p CALU -1.26881270980079 2.82496991513463e-22 0.939905146742839 1.91517392012572e-14 MirTarget -0.127685805210865 0.00154345486344185 NA NA NA hsa-miR-29b-3p CALU -0.110721443686039 0.511264554091106 0.939905146742839 1.91517392012572e-14 miRNAWalker2_validate;MirTarget -0.214927999118598 2.02027786559225e-11 NA NA NA hsa-miR-29c-3p CALU -2.08166260448948 8.3238369390898e-24 0.939905146742839 1.91517392012572e-14 MirTarget -0.169580532818862 8.84861591942418e-12 NA NA NA hsa-miR-30a-5p CALU -1.79779915425811 1.93360169837799e-26 0.939905146742839 1.91517392012572e-14 MirTarget -0.100175914427027 0.00115732660505461 NA NA NA hsa-miR-30b-5p CALU -0.400238605368173 0.00346540992719245 0.939905146742839 1.91517392012572e-14 MirTarget -0.279399923762713 1.16472441168897e-12 NA NA NA hsa-miR-30c-5p CALU 0.021222006155897 0.886366656528128 0.939905146742839 1.91517392012572e-14 MirTarget -0.245056951800079 1.74743730332706e-11 NA NA NA hsa-miR-30d-3p CALU -0.577371911152798 2.02950840095287e-06 0.939905146742839 1.91517392012572e-14 MirTarget -0.303444734904181 6.79226985309924e-12 NA NA NA hsa-miR-30d-5p CALU -0.38399848121878 0.000171129616944749 0.939905146742839 1.91517392012572e-14 MirTarget -0.308908358561506 6.52353166271706e-09 NA NA NA hsa-miR-30e-3p CALU -0.890635378639789 1.65740480611339e-16 0.939905146742839 1.91517392012572e-14 MirTarget;mirMAP -0.248122101443432 4.58059387391629e-07 NA NA NA hsa-miR-30e-5p CALU -1.02114836019762 6.81961221797866e-17 0.939905146742839 1.91517392012572e-14 MirTarget -0.372604980017351 1.199558506601e-18 NA NA NA hsa-miR-374a-5p CALU -0.621903385111545 6.61791773205282e-12 0.939905146742839 1.91517392012572e-14 mirMAP -0.228935536896332 0.000130255626599766 NA NA NA hsa-miR-374b-5p CALU -0.288413933608091 0.0041474558664058 0.939905146742839 1.91517392012572e-14 mirMAP -0.195191376322197 0.000366824242963247 NA NA NA hsa-miR-429 CALU 0.559451508722375 0.00563641638673083 0.939905146742839 1.91517392012572e-14 MirTarget;PITA;miRanda -0.200097407392218 3.91670260244277e-14 NA NA NA hsa-miR-497-5p CALU -0.966244470847844 5.26505649147857e-12 0.939905146742839 1.91517392012572e-14 MirTarget -0.129048024424485 0.000779267248260037 NA NA NA hsa-miR-590-3p CALU 0.221436901462551 0.0965904764063157 0.939905146742839 1.91517392012572e-14 MirTarget;miRanda;mirMAP -0.117560484543541 0.0044493316299116 NA NA NA hsa-miR-7-1-3p CALU 1.13646121619622 1.49823237535933e-14 0.939905146742839 1.91517392012572e-14 mirMAP -0.162081945210064 6.78824811320568e-06 NA NA NA hsa-miR-107 CAP2 -0.0447040564279497 0.671618791096755 -1.53387366998839 1.79899109252429e-10 miRanda -0.325709704645838 0.00141894642141344 NA NA NA hsa-miR-320a CAP2 0.801356001806321 4.91397101474502e-09 -1.53387366998839 1.79899109252429e-10 miRanda -0.403531243111982 1.22970555171748e-07 NA NA NA hsa-miR-320b CAP2 1.23473838180754 3.04337566045537e-14 -1.53387366998839 1.79899109252429e-10 miRanda -0.453236092683339 5.06720949720777e-13 NA NA NA hsa-miR-335-3p CAP2 0.336785882180547 0.0542446207938138 -1.53387366998839 1.79899109252429e-10 mirMAP -0.272816322392486 6.90598535672802e-06 NA NA NA hsa-miR-342-3p CAP2 0.99756868977753 9.28499866272332e-10 -1.53387366998839 1.79899109252429e-10 miRanda -0.324881226509812 3.80545627555451e-07 NA NA NA hsa-miR-429 CAP2 0.559451508722375 0.00563641638673083 -1.53387366998839 1.79899109252429e-10 miRanda -0.494408891135352 1.35177051456025e-22 NA NA NA hsa-miR-582-5p CAP2 -0.0366995972742474 0.821827119138923 -1.53387366998839 1.79899109252429e-10 PITA;miRNATAP -0.379289072632866 4.98695976515625e-09 NA NA NA hsa-miR-590-3p CAP2 0.221436901462551 0.0965904764063157 -1.53387366998839 1.79899109252429e-10 PITA;miRanda;mirMAP -0.31758475884935 7.356335308556e-05 NA NA NA hsa-miR-148a-5p CD44 -1.00478606532747 1.38045244999229e-07 0.514048594063278 6.76874484016064e-05 mirMAP -0.115480139810636 7.57127698252041e-05 23861222 In MHCC97H and MHCC97L cells over-expression of miR-148a blocked the EMT process attenuated the expression of CD90 and CD44 biomarkers for liver cancer stem cells and inhibited their migratory capacity liver cancer hsa-miR-15b-5p CD44 0.85315666454713 3.79816274836297e-12 0.514048594063278 6.76874484016064e-05 miRNAWalker2_validate -0.237528584133364 1.15936099501293e-07 NA NA NA hsa-miR-16-5p CD44 0.521122945828175 1.40561786410572e-06 0.514048594063278 6.76874484016064e-05 miRNAWalker2_validate -0.222597466643129 1.82857328346397e-05 NA NA NA hsa-miR-27b-3p CD44 -0.732682718863563 2.26896143573324e-09 0.514048594063278 6.76874484016064e-05 miRNATAP -0.274526978998342 1.05055751395736e-09 NA NA NA hsa-miR-28-5p CD44 -0.026996999089909 0.733047113251652 0.514048594063278 6.76874484016064e-05 miRanda -0.239404856565069 0.00098459140174019 NA NA NA hsa-miR-30a-3p CD44 -2.26144364746452 8.12421214153823e-31 0.514048594063278 6.76874484016064e-05 mirMAP -0.162501421470689 1.27899572928566e-09 NA NA NA hsa-miR-30a-5p CD44 -1.79779915425811 1.93360169837799e-26 0.514048594063278 6.76874484016064e-05 miRNAWalker2_validate -0.225182101899925 4.74750482420153e-13 NA NA NA hsa-miR-30c-2-3p CD44 -1.82791447399693 2.41509888037865e-21 0.514048594063278 6.76874484016064e-05 MirTarget -0.136763339820183 9.83209695557613e-07 NA NA NA hsa-miR-30e-3p CD44 -0.890635378639789 1.65740480611339e-16 0.514048594063278 6.76874484016064e-05 mirMAP -0.359305956849196 7.08711328705326e-13 NA NA NA hsa-miR-320a CD44 0.801356001806321 4.91397101474502e-09 0.514048594063278 6.76874484016064e-05 miRNAWalker2_validate -0.19573807701882 1.33575083613433e-06 NA NA NA hsa-miR-328-3p CD44 0.153404163477345 0.292356842798574 0.514048594063278 6.76874484016064e-05 miRNAWalker2_validate;miRTarBase -0.141524546917592 0.000267865414034235 NA NA NA hsa-miR-340-5p CD44 -0.608415693437977 4.44345153563513e-05 0.514048594063278 6.76874484016064e-05 mirMAP -0.156139686833528 3.29298902031978e-05 NA NA NA hsa-miR-34a-5p CD44 -0.117372471043915 0.364001947180738 0.514048594063278 6.76874484016064e-05 miRNAWalker2_validate;miRTarBase -0.322657500219044 5.76201865182924e-14 25572695;24423412;25044638;21240262;26231042;25551284;27497057;23314380 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;Furthermore we identified CD44 as being targeted by miR-34a in MIBC cells following cisplatin treatment and increased CD44 expression could efficiently reverse the effect of miR-34a on MIBC cell proliferation colongenic potential and chemosensitivity; Cisplatin-based chemotherapy induced demethylation of miR-34a promoter and increased miR-34a expression which in turn sensitized MIBC cells to cisplatin and decreased the tumorigenicity and proliferation of cancer cells that by reducing the production of CD44;Nanocomplex-assisted delivery of miR-34a induces cell apoptosis and suppresses migration proliferation and tumor growth of breast cancer cells via targeting CD44 and a Notch-1-signaling pathway;The microRNA miR 34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44; We identified and validated CD44 as a direct and functional target of miR-34a and found that CD44 knockdown phenocopied miR-34a overexpression in inhibiting prostate cancer regeneration and metastasis;Registered report: the microRNA miR 34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44; Tumors with exogenous miR-34a showed reduced levels of CD44 expression Figure 4A and mutation of two putative miR-34a binding sites in the CD33 3' UTR partially abrogated signal repression in a luciferase assay Figure 4D;MicroRNA 34a functions as an anti metastatic microRNA and suppresses angiogenesis in bladder cancer by directly targeting CD44; In this study we focus on it that microRNA-34a functions as an anti-metastatic microRNA and suppress angiogenesis in bladder cancer by directly targeting CD44; Our study defines a major metastasis and angiogenesis suppressive role for mir-34a a microRNA functions as a tumor suppressor in bladder cancer by directly targeting CD44 which would be helpful as a therapeutic approach to block bladder cancer metastasis;Nanovesicle mediated systemic delivery of microRNA 34a for CD44 overexpressing gastric cancer stem cell therapy; MicroRNA-34a miR-34a is a promising candidate for CD44 repression-based cancer therapy as it has been reported to inhibit proliferation metastasis and survival of CD44-positive CSCs; Here we used nanovesicles containing PLI/miR complexes NVs/miR to systemically deliver miR-34a and induce miR-34a-triggered CD44 suppression in orthotopically and subcutaneously implanted tumors in nude mice;miR 34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44; The ectopic overexpression of miR-34a significantly inhibited the migration and invasive ability of osteosarcoma cells by repressing the expression of CD44; These data suggest that miR-34a plays a tumor suppressor role in the metastasis of osteosarcoma cells by repressing the expression of CD44; Therefore it can be concluded that through the inhibition of CD44 expression levels miR-34a plays a significant role in the migration and invasion of osteosarcoma cells ;;;metastasis;metastasis;metastasis;metastasis;poor survival;metastasis bladder cancer;bladder cancer;breast cancer;prostate cancer;prostate cancer;bladder cancer;gastric cancer;sarcoma hsa-miR-532-3p CD44 0.80240056676907 1.08989551712617e-09 0.514048594063278 6.76874484016064e-05 miRNATAP -0.174388545888665 3.62840709154934e-05 NA NA NA hsa-let-7c-5p CD59 -2.07953368242668 3.46048888391218e-23 -0.502430795903633 4.50855966473365e-05 MirTarget -0.122235365787528 5.43511868256332e-07 NA NA NA hsa-let-7d-5p CD59 0.481757661442508 3.66030810124939e-07 -0.502430795903633 4.50855966473365e-05 MirTarget -0.243669737811665 1.71098707768577e-05 NA NA NA hsa-let-7g-5p CD59 -0.250780249469264 0.00939610188330072 -0.502430795903633 4.50855966473365e-05 MirTarget -0.237467960834776 2.30786172961812e-05 NA NA NA hsa-let-7i-5p CD59 0.249440992451337 0.00426823922424972 -0.502430795903633 4.50855966473365e-05 MirTarget -0.182140021291664 0.00355985241184027 NA NA NA hsa-miR-10a-5p CD59 -0.316491613573591 0.148093857656453 -0.502430795903633 4.50855966473365e-05 miRNAWalker2_validate -0.112562033218801 4.32237111289991e-06 NA NA NA hsa-miR-141-3p CD59 0.730011517758706 0.000120338355004032 -0.502430795903633 4.50855966473365e-05 mirMAP -0.119206889838733 2.26274930196862e-05 NA NA NA hsa-miR-200a-3p CD59 0.607140814457753 0.00289840524858752 -0.502430795903633 4.50855966473365e-05 mirMAP -0.143526467579648 3.85146965352633e-08 NA NA NA hsa-miR-335-3p CD59 0.336785882180547 0.0542446207938138 -0.502430795903633 4.50855966473365e-05 mirMAP -0.220045395771485 3.17661503455656e-13 NA NA NA hsa-miR-590-3p CD59 0.221436901462551 0.0965904764063157 -0.502430795903633 4.50855966473365e-05 mirMAP -0.109439891619669 0.00711456937781919 NA NA NA hsa-miR-92a-3p CD59 0.994679542307232 1.32587679156217e-16 -0.502430795903633 4.50855966473365e-05 miRNAWalker2_validate -0.23783671505768 3.86940571138463e-08 NA NA NA hsa-miR-98-5p CD59 0.0176698653376732 0.858271091070735 -0.502430795903633 4.50855966473365e-05 MirTarget -0.149498016947214 0.00672686542363331 NA NA NA hsa-miR-126-5p CDH11 -0.953529188793816 7.91719143295591e-16 1.97266716853477 3.00765389464258e-12 mirMAP -0.402176349977272 0.000102922336664085 NA NA NA hsa-miR-130a-3p CDH11 0.67051191119964 4.89747518735144e-06 1.97266716853477 3.00765389464258e-12 mirMAP -0.35134515412094 3.5331735495154e-05 NA NA NA hsa-miR-139-5p CDH11 -1.46099200329485 7.85040381494472e-22 1.97266716853477 3.00765389464258e-12 miRanda -0.368460708222262 3.11535505197651e-06 NA NA NA hsa-miR-144-5p CDH11 -1.00191595665045 9.05682140522593e-05 1.97266716853477 3.00765389464258e-12 mirMAP -0.156947799708392 0.00129856153655562 NA NA NA hsa-miR-16-2-3p CDH11 1.1567130855258 1.01867256952189e-14 1.97266716853477 3.00765389464258e-12 mirMAP -0.563471554346696 2.75587311871219e-12 NA NA NA hsa-miR-200b-3p CDH11 0.0717138787925347 0.682858087587209 1.97266716853477 3.00765389464258e-12 TargetScan -0.557658857782131 1.70110411638028e-15 NA NA NA hsa-miR-205-3p CDH11 1.2960640797621 5.80786479909147e-11 1.97266716853477 3.00765389464258e-12 mirMAP -0.415614092166822 1.22471707221922e-11 NA NA NA hsa-miR-224-3p CDH11 0.502645536188015 0.0081142387260641 1.97266716853477 3.00765389464258e-12 mirMAP -0.278858340774846 2.67116695404247e-05 NA NA NA hsa-miR-362-3p CDH11 -0.697212068252854 2.61718493418184e-06 1.97266716853477 3.00765389464258e-12 miRanda -0.389573588285651 3.64181735608108e-06 NA NA NA hsa-miR-429 CDH11 0.559451508722375 0.00563641638673083 1.97266716853477 3.00765389464258e-12 PITA;miRanda -0.434561942023227 9.74256746816864e-13 NA NA NA hsa-miR-454-3p CDH11 1.54137391927201 4.15861570449376e-20 1.97266716853477 3.00765389464258e-12 mirMAP -0.328877830995681 4.72367053205879e-06 NA NA NA hsa-miR-500a-5p CDH11 0.675401699376111 8.24389004707854e-05 1.97266716853477 3.00765389464258e-12 mirMAP -0.278237055559481 0.000133145957041434 NA NA NA hsa-miR-576-5p CDH11 0.940432050128373 6.90227595663302e-12 1.97266716853477 3.00765389464258e-12 PITA;mirMAP;miRNATAP -0.409205196357087 5.09680233481808e-06 NA NA NA hsa-miR-590-3p CDH11 0.221436901462551 0.0965904764063157 1.97266716853477 3.00765389464258e-12 miRanda;mirMAP -0.373804104113753 7.68901502093795e-05 NA NA NA hsa-miR-7-1-3p CDH11 1.13646121619622 1.49823237535933e-14 1.97266716853477 3.00765389464258e-12 mirMAP -0.398545175807984 1.38489556853487e-06 NA NA NA hsa-miR-26b-5p CDH2 -0.254478038884324 0.0285227763044636 0.521584063757196 0.144910415960722 miRNATAP -0.392689510048831 0.0035988107337841 NA NA NA hsa-miR-27b-5p CDH2 0.580870079022649 0.000181529223377382 0.521584063757196 0.144910415960722 miRNAWalker2_validate -0.713486757324023 3.41420327096682e-13 NA NA NA hsa-miR-429 CDH2 0.559451508722375 0.00563641638673083 0.521584063757196 0.144910415960722 miRanda -0.455805195796428 1.9560501924005e-09 NA NA NA hsa-miR-452-5p CDH2 0.373288744398455 0.0348485937209964 0.521584063757196 0.144910415960722 miRNATAP -0.280367879376849 0.00145343246024854 NA NA NA hsa-miR-532-3p CDH2 0.80240056676907 1.08989551712617e-09 0.521584063757196 0.144910415960722 PITA -0.348234898292967 0.00290941334006831 NA NA NA hsa-miR-582-5p CDH2 -0.0366995972742474 0.821827119138923 0.521584063757196 0.144910415960722 miRNATAP -0.282916246509529 0.00318562203974038 NA NA NA hsa-miR-590-3p CDH2 0.221436901462551 0.0965904764063157 0.521584063757196 0.144910415960722 miRanda -0.350672986188066 0.00282381904131401 NA NA NA hsa-miR-624-5p CDH2 -0.229389464626096 0.110488966509615 0.521584063757196 0.144910415960722 MirTarget -0.578009348764328 8.95461053675244e-08 NA NA NA hsa-miR-7-1-3p CDH2 1.13646121619622 1.49823237535933e-14 0.521584063757196 0.144910415960722 mirMAP -0.457576350567721 7.85029173136281e-06 NA NA NA hsa-miR-200a-5p CDH6 0.701063526850019 0.000188402923774663 1.05455345206971 2.66905970320971e-07 mirMAP -0.222962611029545 2.74683322887713e-06 NA NA NA hsa-miR-200b-3p CDH6 0.0717138787925347 0.682858087587209 1.05455345206971 2.66905970320971e-07 TargetScan -0.2704439709138 1.19116272655033e-07 NA NA NA hsa-miR-20a-3p CDH6 1.34885093664027 2.07697464119202e-12 1.05455345206971 2.66905970320971e-07 mirMAP -0.166324584426649 0.000293897428181703 NA NA NA hsa-miR-24-1-5p CDH6 -0.0503110566834755 0.742860080224713 1.05455345206971 2.66905970320971e-07 MirTarget -0.254745935097952 1.47355467325579e-05 NA NA NA hsa-miR-24-2-5p CDH6 1.27293931700635 4.48240091510596e-15 1.05455345206971 2.66905970320971e-07 MirTarget -0.147030338244296 0.00668364461691744 NA NA NA hsa-miR-29a-5p CDH6 0.323252792625584 0.0370417231222825 1.05455345206971 2.66905970320971e-07 mirMAP -0.240564703191887 3.4523130389111e-05 NA NA NA hsa-miR-339-5p CDH6 1.07771430326938 2.45772601859307e-09 1.05455345206971 2.66905970320971e-07 miRanda -0.249674173681121 3.15145985911196e-07 NA NA NA hsa-miR-3607-3p CDH6 1.01377165357363 9.13355519701165e-05 1.05455345206971 2.66905970320971e-07 mirMAP -0.137861084836774 6.4681672502375e-05 NA NA NA hsa-miR-374b-5p CDH6 -0.288413933608091 0.0041474558664058 1.05455345206971 2.66905970320971e-07 mirMAP -0.248937795022832 0.00589880709671714 NA NA NA hsa-miR-429 CDH6 0.559451508722375 0.00563641638673083 1.05455345206971 2.66905970320971e-07 miRanda;miRNATAP -0.231685051592729 1.55864608422268e-07 NA NA NA hsa-miR-501-3p CDH6 0.820141346319976 1.74562930463389e-08 1.05455345206971 2.66905970320971e-07 MirTarget -0.174322660194867 0.00455177468963908 NA NA NA hsa-miR-576-5p CDH6 0.940432050128373 6.90227595663302e-12 1.05455345206971 2.66905970320971e-07 PITA;mirMAP -0.261075583006628 5.1413433802779e-05 NA NA NA hsa-miR-582-5p CDH6 -0.0366995972742474 0.821827119138923 1.05455345206971 2.66905970320971e-07 mirMAP -0.21882583663568 7.76962859237589e-05 NA NA NA hsa-miR-590-3p CDH6 0.221436901462551 0.0965904764063157 1.05455345206971 2.66905970320971e-07 miRanda -0.210525353924258 0.00195967911098493 NA NA NA hsa-miR-664a-3p CDH6 -0.256108763664991 0.0513188660751664 1.05455345206971 2.66905970320971e-07 mirMAP -0.220073164603907 0.00140469104061211 NA NA NA hsa-miR-7-1-3p CDH6 1.13646121619622 1.49823237535933e-14 1.05455345206971 2.66905970320971e-07 mirMAP -0.222795378271918 0.00017940758481186 NA NA NA hsa-miR-126-5p COL11A1 -0.953529188793816 7.91719143295591e-16 4.4825224870093 1.01558568875229e-19 MirTarget;mirMAP -1.34200823775007 9.29948013795826e-14 NA NA NA hsa-miR-139-5p COL11A1 -1.46099200329485 7.85040381494472e-22 4.4825224870093 1.01558568875229e-19 miRanda -1.02546120025521 1.03088785578885e-13 NA NA NA hsa-miR-141-3p COL11A1 0.730011517758706 0.000120338355004032 4.4825224870093 1.01558568875229e-19 miRNATAP -0.489210344197932 2.65931267020445e-05 NA NA NA hsa-miR-16-2-3p COL11A1 1.1567130855258 1.01867256952189e-14 4.4825224870093 1.01558568875229e-19 MirTarget;mirMAP -0.793706349717734 3.70247476738562e-08 NA NA NA hsa-miR-200a-3p COL11A1 0.607140814457753 0.00289840524858752 4.4825224870093 1.01558568875229e-19 miRNATAP -0.617310519967483 1.06705212092633e-08 NA NA NA hsa-miR-200c-5p COL11A1 0.904697667677842 1.36157973413856e-06 4.4825224870093 1.01558568875229e-19 MirTarget;miRNATAP -0.456605088728074 0.000105026009260477 NA NA NA hsa-miR-20a-3p COL11A1 1.34885093664027 2.07697464119202e-12 4.4825224870093 1.01558568875229e-19 MirTarget -0.298280530116839 0.00883463606547536 NA NA NA hsa-miR-217 COL11A1 -1.35391381055929 2.42394951427902e-09 4.4825224870093 1.01558568875229e-19 miRanda -0.306967038380973 0.00150459510547036 NA NA NA hsa-miR-26a-5p COL11A1 -1.09269574587169 1.24020612216319e-22 4.4825224870093 1.01558568875229e-19 miRNATAP -0.845199151340604 1.04113958696724e-05 NA NA NA hsa-miR-26b-5p COL11A1 -0.254478038884324 0.0285227763044636 4.4825224870093 1.01558568875229e-19 miRNATAP -1.246731711804 5.32639728576673e-11 NA NA NA hsa-miR-29a-3p COL11A1 -1.26881270980079 2.82496991513463e-22 4.4825224870093 1.01558568875229e-19 MirTarget;miRNATAP -1.18153876520945 1.97597400724946e-13 NA NA NA hsa-miR-29b-3p COL11A1 -0.110721443686039 0.511264554091106 4.4825224870093 1.01558568875229e-19 MirTarget;miRNATAP -1.1231268197747 2.42844002358192e-18 NA NA NA hsa-miR-29c-3p COL11A1 -2.08166260448948 8.3238369390898e-24 4.4825224870093 1.01558568875229e-19 MirTarget;miRNATAP -0.888389234753466 4.65052946041717e-19 NA NA NA hsa-miR-3065-3p COL11A1 -0.543069092777161 0.0213164885178151 4.4825224870093 1.01558568875229e-19 MirTarget;miRNATAP -0.391184375835646 3.18989659609525e-05 NA NA NA hsa-miR-32-5p COL11A1 -0.317310201890053 0.0102525324475293 4.4825224870093 1.01558568875229e-19 MirTarget -0.985870183812044 3.8723938106074e-08 NA NA NA hsa-miR-335-5p COL11A1 -1.17227779671552 1.49282618530733e-10 4.4825224870093 1.01558568875229e-19 miRNAWalker2_validate -0.549561276857683 3.9782797025282e-06 NA NA NA hsa-miR-339-5p COL11A1 1.07771430326938 2.45772601859307e-09 4.4825224870093 1.01558568875229e-19 MirTarget;PITA;miRanda -0.389172914213775 0.00137502739859511 NA NA NA hsa-miR-362-3p COL11A1 -0.697212068252854 2.61718493418184e-06 4.4825224870093 1.01558568875229e-19 miRanda -0.888956622741852 1.95731519616658e-09 NA NA NA hsa-miR-363-3p COL11A1 -0.608157508016978 0.0186109501272176 4.4825224870093 1.01558568875229e-19 MirTarget -0.595424713447382 1.82270027142888e-12 NA NA NA hsa-miR-374a-3p COL11A1 -0.299190081500425 0.00682975596757891 4.4825224870093 1.01558568875229e-19 MirTarget;miRNATAP -0.574025942072727 0.00467343036457398 NA NA NA hsa-miR-374a-5p COL11A1 -0.621903385111545 6.61791773205282e-12 4.4825224870093 1.01558568875229e-19 mirMAP -1.34786355558138 2.4375122961909e-08 NA NA NA hsa-miR-374b-5p COL11A1 -0.288413933608091 0.0041474558664058 4.4825224870093 1.01558568875229e-19 mirMAP -0.70256973411759 0.00165258203674733 NA NA NA hsa-miR-429 COL11A1 0.559451508722375 0.00563641638673083 4.4825224870093 1.01558568875229e-19 miRanda -0.502817523904737 4.42458869167948e-06 NA NA NA hsa-miR-590-3p COL11A1 0.221436901462551 0.0965904764063157 4.4825224870093 1.01558568875229e-19 miRanda;mirMAP -0.805502231520885 1.41434684555678e-06 NA NA NA hsa-miR-664a-3p COL11A1 -0.256108763664991 0.0513188660751664 4.4825224870093 1.01558568875229e-19 mirMAP -0.593389348399343 0.000489960028179092 NA NA NA hsa-miR-7-1-3p COL11A1 1.13646121619622 1.49823237535933e-14 4.4825224870093 1.01558568875229e-19 mirMAP -0.575573375900398 8.96452034191966e-05 NA NA NA hsa-miR-92a-3p COL11A1 0.994679542307232 1.32587679156217e-16 4.4825224870093 1.01558568875229e-19 MirTarget -0.554004286301943 0.00219125593687662 NA NA NA hsa-miR-126-5p COL12A1 -0.953529188793816 7.91719143295591e-16 2.79108836051808 1.21317193345327e-27 mirMAP -0.506660270231937 1.45320830905727e-07 NA NA NA hsa-miR-142-3p COL12A1 1.12754191614028 1.68798138028946e-08 2.79108836051808 1.21317193345327e-27 miRanda -0.223633433481389 0.000114753830591474 NA NA NA hsa-miR-15a-5p COL12A1 0.783550182002274 2.60699595655907e-11 2.79108836051808 1.21317193345327e-27 MirTarget;miRNATAP -0.32194957185251 0.00112011259600869 NA NA NA hsa-miR-15b-5p COL12A1 0.85315666454713 3.79816274836297e-12 2.79108836051808 1.21317193345327e-27 MirTarget;miRNATAP -0.423989069158858 6.22926198150186e-06 NA NA NA hsa-miR-16-5p COL12A1 0.521122945828175 1.40561786410572e-06 2.79108836051808 1.21317193345327e-27 MirTarget;miRNATAP -0.583303815587667 6.28213608404699e-08 NA NA NA hsa-miR-17-3p COL12A1 -0.0127974722290336 0.909559935689875 2.79108836051808 1.21317193345327e-27 MirTarget;miRNATAP -0.529864185406124 4.09421535380891e-07 NA NA NA hsa-miR-195-5p COL12A1 -1.8367376818177 6.9944883988895e-31 2.79108836051808 1.21317193345327e-27 MirTarget;miRNATAP -0.2428743307745 0.000497362047760176 NA NA NA hsa-miR-25-3p COL12A1 0.76549796417801 3.32282098247097e-11 2.79108836051808 1.21317193345327e-27 miRNATAP -0.476235090414632 1.94639207785134e-06 NA NA NA hsa-miR-26a-5p COL12A1 -1.09269574587169 1.24020612216319e-22 2.79108836051808 1.21317193345327e-27 miRNATAP -0.587602278913377 5.02484783826404e-09 NA NA NA hsa-miR-26b-5p COL12A1 -0.254478038884324 0.0285227763044636 2.79108836051808 1.21317193345327e-27 miRNATAP -0.675734811051072 1.537640838529e-11 NA NA NA hsa-miR-30a-3p COL12A1 -2.26144364746452 8.12421214153823e-31 2.79108836051808 1.21317193345327e-27 miRNATAP -0.310802824014335 2.86588656388077e-08 NA NA NA hsa-miR-30a-5p COL12A1 -1.79779915425811 1.93360169837799e-26 2.79108836051808 1.21317193345327e-27 mirMAP -0.462488555743646 1.11862242332769e-12 NA NA NA hsa-miR-30b-5p COL12A1 -0.400238605368173 0.00346540992719245 2.79108836051808 1.21317193345327e-27 mirMAP -0.757153540212293 8.78346074666373e-20 NA NA NA hsa-miR-30c-5p COL12A1 0.021222006155897 0.886366656528128 2.79108836051808 1.21317193345327e-27 mirMAP -0.488789984302368 4.84964898290705e-10 NA NA NA hsa-miR-30d-3p COL12A1 -0.577371911152798 2.02950840095287e-06 2.79108836051808 1.21317193345327e-27 miRNATAP -0.831139560359018 6.79936465581267e-19 NA NA NA hsa-miR-30d-5p COL12A1 -0.38399848121878 0.000171129616944749 2.79108836051808 1.21317193345327e-27 mirMAP -0.839258047625254 1.25530628239237e-13 NA NA NA hsa-miR-32-5p COL12A1 -0.317310201890053 0.0102525324475293 2.79108836051808 1.21317193345327e-27 miRNATAP -0.716489099172258 1.72223995874695e-14 NA NA NA hsa-miR-335-3p COL12A1 0.336785882180547 0.0542446207938138 2.79108836051808 1.21317193345327e-27 mirMAP -0.230473572987626 0.000614692729801051 NA NA NA hsa-miR-338-3p COL12A1 -0.948755228846395 8.99167125682392e-08 2.79108836051808 1.21317193345327e-27 miRanda -0.302166505855211 3.64109546840276e-06 NA NA NA hsa-miR-342-3p COL12A1 0.99756868977753 9.28499866272332e-10 2.79108836051808 1.21317193345327e-27 miRanda -0.200517549525671 0.00490028764917943 NA NA NA hsa-miR-34a-5p COL12A1 -0.117372471043915 0.364001947180738 2.79108836051808 1.21317193345327e-27 MirTarget;miRNATAP -0.751987369838993 2.82354713347494e-17 NA NA NA hsa-miR-375 COL12A1 -4.24070205340868 7.48368361454041e-28 2.79108836051808 1.21317193345327e-27 miRNAWalker2_validate -0.235592014825707 2.91295493093351e-17 NA NA NA hsa-miR-497-5p COL12A1 -0.966244470847844 5.26505649147857e-12 2.79108836051808 1.21317193345327e-27 MirTarget;miRNATAP -0.427266305193145 1.82171150504516e-07 NA NA NA hsa-miR-502-3p COL12A1 -0.165138869760313 0.106881047403914 2.79108836051808 1.21317193345327e-27 PITA -0.528869082827324 4.62397079757943e-06 NA NA NA hsa-miR-532-5p COL12A1 -0.021857649390892 0.830992272120134 2.79108836051808 1.21317193345327e-27 PITA -0.660444182212024 9.13239154868202e-09 NA NA NA hsa-miR-590-3p COL12A1 0.221436901462551 0.0965904764063157 2.79108836051808 1.21317193345327e-27 miRanda -0.335130007641631 0.00015383685744469 NA NA NA hsa-miR-590-5p COL12A1 0.763025362395968 3.65305892505623e-09 2.79108836051808 1.21317193345327e-27 PITA;miRanda -0.364220290838389 4.98750598679385e-05 NA NA NA hsa-miR-9-5p COL12A1 1.65694862043766 2.08325802567323e-05 2.79108836051808 1.21317193345327e-27 miRNAWalker2_validate;miRNATAP -0.214474739937503 2.70993698119158e-13 NA NA NA hsa-miR-92a-3p COL12A1 0.994679542307232 1.32587679156217e-16 2.79108836051808 1.21317193345327e-27 miRNATAP -0.315311888093146 0.000950967696567704 NA NA NA hsa-miR-29a-3p COL16A1 -1.26881270980079 2.82496991513463e-22 1.68277390098099 1.11581805660747e-16 miRNATAP -0.314408224335916 2.40601087172711e-06 NA NA NA hsa-miR-29c-3p COL16A1 -2.08166260448948 8.3238369390898e-24 1.68277390098099 1.11581805660747e-16 miRNATAP -0.353927090464011 3.91301313318878e-18 NA NA NA hsa-miR-3065-3p COL16A1 -0.543069092777161 0.0213164885178151 1.68277390098099 1.11581805660747e-16 MirTarget;miRNATAP -0.20538033962783 7.66853149254863e-08 NA NA NA hsa-let-7g-5p COL1A1 -0.250780249469264 0.00939610188330072 3.60845872085475 1.44319508672333e-31 miRNATAP -0.48707193020329 0.00111943678913819 NA NA NA hsa-miR-106a-5p COL1A1 0.67978010057847 0.00221925869726092 3.60845872085475 1.44319508672333e-31 mirMAP -0.378624701554961 2.31668674743769e-09 NA NA NA hsa-miR-106b-5p COL1A1 0.50378717276868 1.45412404526866e-05 3.60845872085475 1.44319508672333e-31 mirMAP -0.355915743624106 0.00383148368810334 NA NA NA hsa-miR-126-5p COL1A1 -0.953529188793816 7.91719143295591e-16 3.60845872085475 1.44319508672333e-31 miRNATAP -0.738305464530461 2.2420465965451e-10 NA NA NA hsa-miR-150-5p COL1A1 -0.243749814009231 0.331546276920338 3.60845872085475 1.44319508672333e-31 miRNATAP -0.217456444922139 0.000131201787929862 NA NA NA hsa-miR-17-5p COL1A1 1.41924888736771 2.75805544953758e-18 3.60845872085475 1.44319508672333e-31 mirMAP -0.261608419386794 0.00211205802512542 NA NA NA hsa-miR-20a-5p COL1A1 1.1531986665452 1.02385132917958e-11 3.60845872085475 1.44319508672333e-31 mirMAP -0.337744431652592 4.27390599981122e-05 NA NA NA hsa-miR-20b-5p COL1A1 0.345967670847176 0.232014828043601 3.60845872085475 1.44319508672333e-31 mirMAP -0.324354003057995 2.56729400239008e-11 NA NA NA hsa-miR-23b-5p COL1A1 0.141208007066527 0.420202986869364 3.60845872085475 1.44319508672333e-31 mirMAP -0.454135610386432 5.61640352079574e-08 NA NA NA hsa-miR-29a-3p COL1A1 -1.26881270980079 2.82496991513463e-22 3.60845872085475 1.44319508672333e-31 miRNATAP -0.755516505509511 2.37766075876678e-13 NA NA NA hsa-miR-29b-3p COL1A1 -0.110721443686039 0.511264554091106 3.60845872085475 1.44319508672333e-31 miRNAWalker2_validate;miRTarBase;miRNATAP -0.693661041987726 4.99341901437697e-17 NA NA NA hsa-miR-29c-3p COL1A1 -2.08166260448948 8.3238369390898e-24 3.60845872085475 1.44319508672333e-31 miRNAWalker2_validate;miRTarBase;miRNATAP -0.614769445875042 3.42494446797044e-22 NA NA NA hsa-miR-30a-3p COL1A1 -2.26144364746452 8.12421214153823e-31 3.60845872085475 1.44319508672333e-31 mirMAP -0.307035022599355 7.16091653614776e-06 NA NA NA hsa-miR-30b-3p COL1A1 -0.338530747940815 0.0223424741180399 3.60845872085475 1.44319508672333e-31 miRNATAP -0.563073741013859 4.14464482407918e-09 NA NA NA hsa-miR-30d-3p COL1A1 -0.577371911152798 2.02950840095287e-06 3.60845872085475 1.44319508672333e-31 mirMAP -1.01274432312451 5.34689254881346e-19 NA NA NA hsa-miR-30e-3p COL1A1 -0.890635378639789 1.65740480611339e-16 3.60845872085475 1.44319508672333e-31 mirMAP -0.918604723901982 4.3967834429653e-13 NA NA NA hsa-miR-338-3p COL1A1 -0.948755228846395 8.99167125682392e-08 3.60845872085475 1.44319508672333e-31 miRanda;miRNATAP -0.504275000046221 1.36172634799256e-10 NA NA NA hsa-miR-361-3p COL1A1 0.272298288982435 0.0147874880476998 3.60845872085475 1.44319508672333e-31 PITA -0.461502009370834 0.000334039259550113 NA NA NA hsa-miR-590-3p COL1A1 0.221436901462551 0.0965904764063157 3.60845872085475 1.44319508672333e-31 miRanda -0.469005029407127 1.24860032120008e-05 NA NA NA hsa-miR-92a-1-5p COL1A1 1.41314158431819 2.67965667765933e-11 3.60845872085475 1.44319508672333e-31 MirTarget -0.273853190960453 3.43626577630272e-05 NA NA NA hsa-let-7a-3p COL1A2 0.0966652362351867 0.423761916840503 2.67440414460036 8.77041031170282e-20 MirTarget -0.313413654613553 0.00466605707314106 NA NA NA hsa-let-7g-5p COL1A2 -0.250780249469264 0.00939610188330072 2.67440414460036 8.77041031170282e-20 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.364074886804212 0.00881990633021969 NA NA NA hsa-miR-19a-3p COL1A2 1.35800152353624 2.80940447111944e-12 2.67440414460036 8.77041031170282e-20 MirTarget -0.332207431257499 5.67543084282414e-07 NA NA NA hsa-miR-19b-3p COL1A2 0.538732279378089 0.000622008277870679 2.67440414460036 8.77041031170282e-20 MirTarget -0.59226982751577 7.2435926421866e-13 NA NA NA hsa-miR-25-3p COL1A2 0.76549796417801 3.32282098247097e-11 2.67440414460036 8.77041031170282e-20 MirTarget;miRNATAP -0.347517525858949 0.00222151263145703 NA NA NA hsa-miR-26a-5p COL1A2 -1.09269574587169 1.24020612216319e-22 2.67440414460036 8.77041031170282e-20 MirTarget;miRNATAP -0.367832009718336 0.00133894105701387 NA NA NA hsa-miR-26b-5p COL1A2 -0.254478038884324 0.0285227763044636 2.67440414460036 8.77041031170282e-20 MirTarget;miRNATAP -0.718116378418528 2.33518730766038e-10 NA NA NA hsa-miR-29a-3p COL1A2 -1.26881270980079 2.82496991513463e-22 2.67440414460036 8.77041031170282e-20 miRNATAP -0.621365355705265 1.09712817620421e-10 NA NA NA hsa-miR-29b-3p COL1A2 -0.110721443686039 0.511264554091106 2.67440414460036 8.77041031170282e-20 miRNATAP -0.662281324528488 5.48526034135374e-18 NA NA NA hsa-miR-29c-3p COL1A2 -2.08166260448948 8.3238369390898e-24 2.67440414460036 8.77041031170282e-20 miRNAWalker2_validate;miRTarBase;miRNATAP -0.501355865703863 3.80993079719404e-17 NA NA NA hsa-miR-30a-3p COL1A2 -2.26144364746452 8.12421214153823e-31 2.67440414460036 8.77041031170282e-20 MirTarget -0.192543066949851 0.00255976744747418 NA NA NA hsa-miR-30d-3p COL1A2 -0.577371911152798 2.02950840095287e-06 2.67440414460036 8.77041031170282e-20 MirTarget -0.910264089366439 7.99447576004809e-18 NA NA NA hsa-miR-30e-3p COL1A2 -0.890635378639789 1.65740480611339e-16 2.67440414460036 8.77041031170282e-20 MirTarget -0.711518998980638 2.02501901497149e-09 NA NA NA hsa-miR-32-5p COL1A2 -0.317310201890053 0.0102525324475293 2.67440414460036 8.77041031170282e-20 MirTarget;miRNATAP -0.727915936212518 6.43832518085866e-12 NA NA NA hsa-miR-33a-3p COL1A2 0.20371038027126 0.212335697664505 2.67440414460036 8.77041031170282e-20 MirTarget -0.512792781647199 3.24945943808124e-10 NA NA NA hsa-miR-363-3p COL1A2 -0.608157508016978 0.0186109501272176 2.67440414460036 8.77041031170282e-20 MirTarget -0.359029150456871 9.34526691915003e-13 NA NA NA hsa-miR-590-3p COL1A2 0.221436901462551 0.0965904764063157 2.67440414460036 8.77041031170282e-20 miRanda -0.497732708770646 5.48581795793823e-07 NA NA NA hsa-miR-7-1-3p COL1A2 1.13646121619622 1.49823237535933e-14 2.67440414460036 8.77041031170282e-20 mirMAP -0.479173395898502 3.48645475540795e-08 NA NA NA hsa-miR-92a-3p COL1A2 0.994679542307232 1.32587679156217e-16 2.67440414460036 8.77041031170282e-20 MirTarget;miRNATAP -0.534139883289929 5.86060358609946e-07 NA NA NA hsa-miR-141-5p COL3A1 0.623874471326586 0.0018690552472983 2.96486266329015 3.11817195452463e-22 MirTarget -0.487004471495223 6.35999226841586e-13 NA NA NA hsa-miR-16-2-3p COL3A1 1.1567130855258 1.01867256952189e-14 2.96486266329015 3.11817195452463e-22 MirTarget -0.543140090613586 1.3259298572276e-09 NA NA NA hsa-miR-186-5p COL3A1 0.353452958261612 0.000145058448579496 2.96486266329015 3.11817195452463e-22 miRNATAP -0.405079964801133 0.00711970565841837 NA NA NA hsa-miR-205-3p COL3A1 1.2960640797621 5.80786479909147e-11 2.96486266329015 3.11817195452463e-22 MirTarget -0.429057116337303 2.69517699537805e-10 NA NA NA hsa-miR-29a-3p COL3A1 -1.26881270980079 2.82496991513463e-22 2.96486266329015 3.11817195452463e-22 MirTarget;miRNATAP -0.584053141694914 7.70095409088874e-09 NA NA NA hsa-miR-29b-3p COL3A1 -0.110721443686039 0.511264554091106 2.96486266329015 3.11817195452463e-22 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.661608693641631 1.94215084929088e-16 NA NA NA hsa-miR-29c-3p COL3A1 -2.08166260448948 8.3238369390898e-24 2.96486266329015 3.11817195452463e-22 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.48028419079297 1.78956312716255e-14 NA NA NA hsa-miR-335-5p COL3A1 -1.17227779671552 1.49282618530733e-10 2.96486266329015 3.11817195452463e-22 miRNAWalker2_validate -0.322020467521438 1.47284450747602e-05 NA NA NA hsa-miR-429 COL3A1 0.559451508722375 0.00563641638673083 2.96486266329015 3.11817195452463e-22 miRanda -0.565162725419217 2.20530726860171e-17 NA NA NA hsa-miR-582-3p COL3A1 -0.248056267546012 0.143798829508405 2.96486266329015 3.11817195452463e-22 miRNATAP -0.556069312794025 5.17510355449043e-12 NA NA NA hsa-miR-590-3p COL3A1 0.221436901462551 0.0965904764063157 2.96486266329015 3.11817195452463e-22 miRanda;mirMAP -0.461234993409995 9.65890636139093e-06 NA NA NA hsa-miR-590-5p COL3A1 0.763025362395968 3.65305892505623e-09 2.96486266329015 3.11817195452463e-22 miRanda -0.574148193794035 4.97708305503203e-08 NA NA NA hsa-miR-100-5p COL4A1 -1.85857794619369 1.248973638996e-25 2.83937959905908 7.34135834575235e-47 miRNAWalker2_validate -0.17528260776814 0.000530599939471027 NA NA NA hsa-miR-148a-3p COL4A1 -0.428944290834563 0.00954246923521465 2.83937959905908 7.34135834575235e-47 miRNATAP -0.286681398841711 4.15638136662523e-07 NA NA NA hsa-miR-29a-3p COL4A1 -1.26881270980079 2.82496991513463e-22 2.83937959905908 7.34135834575235e-47 miRNAWalker2_validate;miRTarBase;miRNATAP -0.458043675150706 2.0846229509702e-11 NA NA NA hsa-miR-29b-3p COL4A1 -0.110721443686039 0.511264554091106 2.83937959905908 7.34135834575235e-47 miRNAWalker2_validate;miRTarBase;miRNATAP -0.392743814870725 1.02245016183976e-12 NA NA NA hsa-miR-29c-3p COL4A1 -2.08166260448948 8.3238369390898e-24 2.83937959905908 7.34135834575235e-47 miRNAWalker2_validate;miRTarBase;miRNATAP -0.393329554134978 7.86673995187341e-21 NA NA NA hsa-miR-362-3p COL4A1 -0.697212068252854 2.61718493418184e-06 2.83937959905908 7.34135834575235e-47 miRanda -0.331300898192448 1.43501501024564e-07 NA NA NA hsa-miR-429 COL4A1 0.559451508722375 0.00563641638673083 2.83937959905908 7.34135834575235e-47 miRanda;miRNATAP -0.269582298220837 4.97271679157673e-09 NA NA NA hsa-miR-590-3p COL4A1 0.221436901462551 0.0965904764063157 2.83937959905908 7.34135834575235e-47 miRanda -0.189613239353297 0.00780601536972556 NA NA NA hsa-miR-628-5p COL4A1 -0.554239048796013 4.92386883216087e-05 2.83937959905908 7.34135834575235e-47 PITA;miRNATAP -0.212468502409852 0.00207735055800124 NA NA NA hsa-miR-99a-5p COL4A1 -2.344442285007 7.11841214134739e-24 2.83937959905908 7.34135834575235e-47 miRNAWalker2_validate -0.304245005031332 7.45376710248459e-16 NA NA NA hsa-miR-10a-5p COL4A2 -0.316491613573591 0.148093857656453 2.58872062468549 1.03105600926525e-43 miRNAWalker2_validate -0.112103186643999 0.00573612050062258 NA NA NA hsa-miR-1266-5p COL4A2 -0.595481713934774 0.0201336437562675 2.58872062468549 1.03105600926525e-43 MirTarget -0.159451882030184 5.40322182963185e-06 NA NA NA hsa-miR-26b-5p COL4A2 -0.254478038884324 0.0285227763044636 2.58872062468549 1.03105600926525e-43 miRNAWalker2_validate -0.365751393315261 1.63261727959989e-06 NA NA NA hsa-miR-29a-3p COL4A2 -1.26881270980079 2.82496991513463e-22 2.58872062468549 1.03105600926525e-43 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.397776975185521 6.58826142516059e-10 NA NA NA hsa-miR-29b-3p COL4A2 -0.110721443686039 0.511264554091106 2.58872062468549 1.03105600926525e-43 miRTarBase;MirTarget;miRNATAP -0.297124758156548 1.25722392484829e-08 NA NA NA hsa-miR-29c-3p COL4A2 -2.08166260448948 8.3238369390898e-24 2.58872062468549 1.03105600926525e-43 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.360294864916402 8.15214180862851e-20 NA NA NA hsa-miR-192-5p COL5A1 0.380924502586635 0.00986961967409205 3.17731249877324 1.71191762077256e-30 miRNATAP -0.264580280311584 0.00231121553709619 NA NA NA hsa-miR-224-3p COL5A1 0.502645536188015 0.0081142387260641 3.17731249877324 1.71191762077256e-30 mirMAP -0.241030072554086 0.000372501298137419 NA NA NA hsa-miR-25-3p COL5A1 0.76549796417801 3.32282098247097e-11 3.17731249877324 1.71191762077256e-30 miRNATAP -0.345076295477214 0.00161822271729608 NA NA NA hsa-miR-26a-5p COL5A1 -1.09269574587169 1.24020612216319e-22 3.17731249877324 1.71191762077256e-30 miRNATAP -0.490668414795319 8.19393272918494e-06 NA NA NA hsa-miR-26b-5p COL5A1 -0.254478038884324 0.0285227763044636 3.17731249877324 1.71191762077256e-30 miRNAWalker2_validate;miRNATAP -0.657097965368949 1.90641827850395e-09 NA NA NA hsa-miR-29a-3p COL5A1 -1.26881270980079 2.82496991513463e-22 3.17731249877324 1.71191762077256e-30 MirTarget;miRNATAP -0.623837323558146 1.64814718004168e-11 NA NA NA hsa-miR-29b-3p COL5A1 -0.110721443686039 0.511264554091106 3.17731249877324 1.71191762077256e-30 MirTarget;miRNATAP -0.600953274585485 5.35207251399232e-16 NA NA NA hsa-miR-29c-3p COL5A1 -2.08166260448948 8.3238369390898e-24 3.17731249877324 1.71191762077256e-30 MirTarget;miRNATAP -0.568959591720545 8.82381261995711e-24 NA NA NA hsa-miR-3065-3p COL5A1 -0.543069092777161 0.0213164885178151 3.17731249877324 1.71191762077256e-30 miRNATAP -0.29191378842957 5.33461901165747e-08 NA NA NA hsa-miR-32-5p COL5A1 -0.317310201890053 0.0102525324475293 3.17731249877324 1.71191762077256e-30 miRNATAP -0.621971782282406 1.35604723103884e-09 NA NA NA hsa-miR-338-5p COL5A1 -1.71946558699173 2.62649071488641e-23 3.17731249877324 1.71191762077256e-30 miRNATAP -0.243840826743565 0.000573067278591421 NA NA NA hsa-miR-3653-3p COL5A1 0.107165561163282 0.557264097309856 3.17731249877324 1.71191762077256e-30 MirTarget -0.259054199678892 0.00022058664245225 NA NA NA hsa-miR-582-5p COL5A1 -0.0366995972742474 0.821827119138923 3.17731249877324 1.71191762077256e-30 MirTarget;PITA;miRNATAP -0.561443031733619 3.54658074417765e-13 NA NA NA hsa-miR-590-3p COL5A1 0.221436901462551 0.0965904764063157 3.17731249877324 1.71191762077256e-30 PITA;miRanda;mirMAP;miRNATAP -0.363408419118055 0.000160055053042666 NA NA NA hsa-miR-7-1-3p COL5A1 1.13646121619622 1.49823237535933e-14 3.17731249877324 1.71191762077256e-30 mirMAP -0.372061776627298 9.84726610521338e-06 NA NA NA hsa-miR-9-5p COL5A1 1.65694862043766 2.08325802567323e-05 3.17731249877324 1.71191762077256e-30 miRNATAP -0.170575371935878 1.27759254223403e-07 NA NA NA hsa-miR-92a-3p COL5A1 0.994679542307232 1.32587679156217e-16 3.17731249877324 1.71191762077256e-30 miRNATAP -0.372391806280591 0.00032647100787257 NA NA NA hsa-let-7c-5p COL5A2 -2.07953368242668 3.46048888391218e-23 3.09409293887095 7.44408155884721e-31 MirTarget -0.184522698533589 0.0010943669543038 NA NA NA hsa-let-7g-5p COL5A2 -0.250780249469264 0.00939610188330072 3.09409293887095 7.44408155884721e-31 MirTarget;miRNATAP -0.483485575555391 0.000184725092369389 NA NA NA hsa-miR-126-5p COL5A2 -0.953529188793816 7.91719143295591e-16 3.09409293887095 7.44408155884721e-31 mirMAP -0.532520345760366 1.53011941992049e-07 NA NA NA hsa-miR-148a-5p COL5A2 -1.00478606532747 1.38045244999229e-07 3.09409293887095 7.44408155884721e-31 MirTarget -0.29839813949196 3.01718422011844e-06 NA NA NA hsa-miR-16-2-3p COL5A2 1.1567130855258 1.01867256952189e-14 3.09409293887095 7.44408155884721e-31 MirTarget;mirMAP -0.437849026066234 4.71476791124814e-08 NA NA NA hsa-miR-224-3p COL5A2 0.502645536188015 0.0081142387260641 3.09409293887095 7.44408155884721e-31 MirTarget -0.192225365926561 0.00344568744101619 NA NA NA hsa-miR-29a-3p COL5A2 -1.26881270980079 2.82496991513463e-22 3.09409293887095 7.44408155884721e-31 MirTarget;miRNATAP -0.649610743383307 3.69528638599389e-13 NA NA NA hsa-miR-29b-3p COL5A2 -0.110721443686039 0.511264554091106 3.09409293887095 7.44408155884721e-31 MirTarget;miRNATAP -0.600691295593955 5.22801393453622e-17 NA NA NA hsa-miR-29c-3p COL5A2 -2.08166260448948 8.3238369390898e-24 3.09409293887095 7.44408155884721e-31 MirTarget;miRNATAP -0.550486964224568 9.83321263872894e-24 NA NA NA hsa-miR-30a-3p COL5A2 -2.26144364746452 8.12421214153823e-31 3.09409293887095 7.44408155884721e-31 mirMAP -0.277244374429749 2.84404571294921e-06 NA NA NA hsa-miR-30e-3p COL5A2 -0.890635378639789 1.65740480611339e-16 3.09409293887095 7.44408155884721e-31 mirMAP -0.858983803308727 4.1614194018515e-15 NA NA NA hsa-miR-335-3p COL5A2 0.336785882180547 0.0542446207938138 3.09409293887095 7.44408155884721e-31 MirTarget -0.201036661109779 0.00461878999298422 NA NA NA hsa-miR-335-5p COL5A2 -1.17227779671552 1.49282618530733e-10 3.09409293887095 7.44408155884721e-31 miRNATAP -0.384234860677072 5.30774313869717e-09 NA NA NA hsa-miR-338-5p COL5A2 -1.71946558699173 2.62649071488641e-23 3.09409293887095 7.44408155884721e-31 mirMAP -0.267342014860634 9.41261715561028e-05 NA NA NA hsa-miR-34a-5p COL5A2 -0.117372471043915 0.364001947180738 3.09409293887095 7.44408155884721e-31 MirTarget -0.605906426775711 1.81658311288164e-10 NA NA NA hsa-miR-590-3p COL5A2 0.221436901462551 0.0965904764063157 3.09409293887095 7.44408155884721e-31 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.39395549174331 2.30711346500684e-05 NA NA NA hsa-miR-29a-3p COL5A3 -1.26881270980079 2.82496991513463e-22 1.9232190791722 7.31668535328472e-18 MirTarget;miRNATAP -0.485226527296851 2.64896632939809e-11 NA NA NA hsa-miR-29b-3p COL5A3 -0.110721443686039 0.511264554091106 1.9232190791722 7.31668535328472e-18 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.426809213577516 3.27122959210456e-13 NA NA NA hsa-miR-29c-3p COL5A3 -2.08166260448948 8.3238369390898e-24 1.9232190791722 7.31668535328472e-18 MirTarget;miRNATAP -0.480156486101688 1.30588884746592e-27 NA NA NA hsa-miR-3065-3p COL5A3 -0.543069092777161 0.0213164885178151 1.9232190791722 7.31668535328472e-18 MirTarget;miRNATAP -0.183193248842918 1.53777182317157e-05 NA NA NA hsa-miR-362-3p COL5A3 -0.697212068252854 2.61718493418184e-06 1.9232190791722 7.31668535328472e-18 miRanda -0.347065831470356 2.29166946224941e-07 NA NA NA hsa-miR-429 COL5A3 0.559451508722375 0.00563641638673083 1.9232190791722 7.31668535328472e-18 miRanda -0.376636866618283 7.88511743169413e-15 NA NA NA hsa-miR-625-5p COL5A3 0.346770617079364 0.02860843739549 1.9232190791722 7.31668535328472e-18 mirMAP -0.226486269866342 0.000390930135587879 NA NA NA hsa-miR-10b-5p COL6A2 -0.582989331935508 4.56688330655626e-06 1.83065662029131 3.89479005128054e-15 miRNAWalker2_validate -0.302378140664072 0.000208192107867274 NA NA NA hsa-miR-29a-3p COL6A3 -1.26881270980079 2.82496991513463e-22 2.57622836239592 8.76789052806367e-21 MirTarget;miRNATAP -0.447818965900922 9.22881745164829e-07 NA NA NA hsa-miR-29b-3p COL6A3 -0.110721443686039 0.511264554091106 2.57622836239592 8.76789052806367e-21 MirTarget;miRNATAP -0.574756207734078 2.06681631428782e-15 NA NA NA hsa-miR-29c-3p COL6A3 -2.08166260448948 8.3238369390898e-24 2.57622836239592 8.76789052806367e-21 MirTarget;miRNATAP -0.36706530930726 9.84203432236703e-11 NA NA NA hsa-miR-362-3p COL6A3 -0.697212068252854 2.61718493418184e-06 2.57622836239592 8.76789052806367e-21 miRanda -0.441634367480162 1.11407246570406e-07 NA NA NA hsa-miR-429 COL6A3 0.559451508722375 0.00563641638673083 2.57622836239592 8.76789052806367e-21 miRNATAP -0.490897878485218 2.77756213823698e-16 NA NA NA hsa-miR-590-3p COL6A3 0.221436901462551 0.0965904764063157 2.57622836239592 8.76789052806367e-21 miRanda -0.382958054737009 4.4275543696127e-05 NA NA NA hsa-miR-29a-3p COL7A1 -1.26881270980079 2.82496991513463e-22 2.45343158894686 2.7420845374156e-37 MirTarget;miRNATAP -0.461160143144931 1.38740732992402e-12 NA NA NA hsa-miR-29c-3p COL7A1 -2.08166260448948 8.3238369390898e-24 2.45343158894686 2.7420845374156e-37 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.40352350035862 3.9390269160116e-24 NA NA NA hsa-miR-3065-3p COL7A1 -0.543069092777161 0.0213164885178151 2.45343158894686 2.7420845374156e-37 MirTarget;miRNATAP -0.102785780666991 0.007121725875604 NA NA NA hsa-miR-106a-5p COL8A2 0.67978010057847 0.00221925869726092 0.64148317048179 0.00235805846516419 mirMAP -0.191371903233135 3.16539704445585e-06 NA NA NA hsa-miR-106b-5p COL8A2 0.50378717276868 1.45412404526866e-05 0.64148317048179 0.00235805846516419 mirMAP -0.204925860959253 0.00975178353337579 NA NA NA hsa-miR-17-5p COL8A2 1.41924888736771 2.75805544953758e-18 0.64148317048179 0.00235805846516419 mirMAP -0.350000969623576 8.63072501743958e-11 NA NA NA hsa-miR-194-3p COL8A2 0.735945243226384 8.65425299041628e-05 0.64148317048179 0.00235805846516419 MirTarget -0.133240589668661 0.00778556360814767 NA NA NA hsa-miR-20a-5p COL8A2 1.1531986665452 1.02385132917958e-11 0.64148317048179 0.00235805846516419 mirMAP -0.323049637676893 8.16703292882713e-10 NA NA NA hsa-miR-20b-5p COL8A2 0.345967670847176 0.232014828043601 0.64148317048179 0.00235805846516419 mirMAP -0.116812942893745 0.000235954139050029 NA NA NA hsa-miR-3127-5p COL8A2 0.706677736144125 1.91821443636366e-05 0.64148317048179 0.00235805846516419 MirTarget -0.189598566830045 0.000612354753562353 NA NA NA hsa-miR-335-5p COL8A2 -1.17227779671552 1.49282618530733e-10 0.64148317048179 0.00235805846516419 miRNAWalker2_validate -0.168862912265942 0.000633939910906231 NA NA NA hsa-miR-361-3p COL8A2 0.272298288982435 0.0147874880476998 0.64148317048179 0.00235805846516419 MirTarget;mirMAP -0.223464848360129 0.00711690118898007 NA NA NA hsa-miR-3614-5p COL8A2 0.955957969488529 2.95347675446694e-05 0.64148317048179 0.00235805846516419 MirTarget;miRNATAP -0.121039863358266 0.00247570237601282 NA NA NA hsa-miR-582-5p COL8A2 -0.0366995972742474 0.821827119138923 0.64148317048179 0.00235805846516419 PITA -0.321110767188026 1.02667456065966e-08 NA NA NA hsa-miR-146b-5p COPA 0.917975986853978 3.33749259316025e-09 0.0942369041739326 0.25753822791035 miRanda -0.10625037926566 3.19300238803294e-06 NA NA NA hsa-miR-320a COPA 0.801356001806321 4.91397101474502e-09 0.0942369041739326 0.25753822791035 miRanda -0.149400625873557 6.53366819353847e-09 NA NA NA hsa-miR-423-3p COPA 1.20230884409188 2.57129723627633e-23 0.0942369041739326 0.25753822791035 miRNAWalker2_validate -0.11606289021786 4.92237249131148e-05 NA NA NA hsa-miR-7-1-3p COPA 1.13646121619622 1.49823237535933e-14 0.0942369041739326 0.25753822791035 MirTarget -0.101641603051904 1.84155851495349e-05 NA NA NA hsa-miR-342-3p CRLF1 0.99756868977753 9.28499866272332e-10 -0.548692166684164 0.0900917514240516 miRanda -0.296694952433994 0.000493131441946397 NA NA NA hsa-miR-149-5p CTGF 0.443278770827687 0.0642022866136881 -0.699854006306855 0.00293574224012784 miRNATAP -0.206067639335264 1.29166217789756e-06 NA NA NA hsa-miR-16-2-3p CTGF 1.1567130855258 1.01867256952189e-14 -0.699854006306855 0.00293574224012784 MirTarget -0.582055075675304 2.84038268255854e-19 NA NA NA hsa-miR-18a-5p CTGF 1.65455873230328 3.76457892277775e-20 -0.699854006306855 0.00293574224012784 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.362421184621041 2.05011746973646e-11 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling poor survival glioblastoma hsa-miR-19a-3p CTGF 1.35800152353624 2.80940447111944e-12 -0.699854006306855 0.00293574224012784 MirTarget;miRNATAP -0.335760671812675 4.25852281864162e-11 NA NA NA hsa-miR-19b-3p CTGF 0.538732279378089 0.000622008277870679 -0.699854006306855 0.00293574224012784 MirTarget;miRNATAP -0.381940203186411 2.89765714201214e-09 NA NA NA hsa-miR-205-5p CTGF 1.50759485376634 2.0003886738248e-16 -0.699854006306855 0.00293574224012784 miRNAWalker2_validate;miRTarBase -0.525166028191004 6.48498496273652e-24 NA NA NA hsa-miR-26b-3p CTGF 0.421575313079363 0.00223298166810883 -0.699854006306855 0.00293574224012784 MirTarget;miRNATAP -0.369243091033105 6.07071431559366e-07 25761878 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1 sarcoma hsa-miR-26b-5p CTGF -0.254478038884324 0.0285227763044636 -0.699854006306855 0.00293574224012784 miRNATAP -0.237207034513592 0.00770467360550299 25761878 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1 sarcoma hsa-miR-361-3p CTGF 0.272298288982435 0.0147874880476998 -0.699854006306855 0.00293574224012784 MirTarget;miRNATAP -0.296605329970702 0.0013393001654514 NA NA NA hsa-miR-590-3p CTGF 0.221436901462551 0.0965904764063157 -0.699854006306855 0.00293574224012784 PITA;miRanda -0.337560595220434 1.18646746550991e-05 NA NA NA hsa-miR-7-1-3p CTGF 1.13646121619622 1.49823237535933e-14 -0.699854006306855 0.00293574224012784 MirTarget -0.527490782721506 1.52723259205055e-15 NA NA NA hsa-miR-30a-5p CTHRC1 -1.79779915425811 1.93360169837799e-26 3.40477771423069 4.66292028528871e-38 MirTarget -0.254457920406936 0.000260419020227386 NA NA NA hsa-miR-30b-5p CTHRC1 -0.400238605368173 0.00346540992719245 3.40477771423069 4.66292028528871e-38 MirTarget -0.404011870870783 7.55471635879329e-06 26388700 MiR-30b was down-regulated and Cthrc1 up-regulated in NSCLC tissues; Bioinformatics analysis identified Cthrc1 as a target of miR-30b and western blotting and luciferase reporter assays confirmed that miR-30b regulates Cthrc1 by directly binding to its 3'UTR; Transfection of Cthrc1 without the 3'UTR restored the miR-30b inhibiting cell invasion; Up-regulation of miR-30b or down-regulation of Cthrc1 had potential significance in the invasion and metastasis of NSCLC; MiR-30b was down-regulated and Cthrc1 up-regulated in NSCLC tissues; MiR-30b affected NSCLC cells invasion and migration by regulating Cthrc1 metastasis lung squamous cell cancer hsa-miR-30d-5p CTHRC1 -0.38399848121878 0.000171129616944749 3.40477771423069 4.66292028528871e-38 MirTarget -0.67189906074994 2.54567522325564e-08 NA NA NA hsa-miR-30e-5p CTHRC1 -1.02114836019762 6.81961221797866e-17 3.40477771423069 4.66292028528871e-38 MirTarget -0.831601202022442 3.8259970132332e-18 NA NA NA hsa-miR-335-5p CTHRC1 -1.17227779671552 1.49282618530733e-10 3.40477771423069 4.66292028528871e-38 miRNAWalker2_validate -0.233712011072241 0.000443054656567175 NA NA NA hsa-miR-590-3p CTHRC1 0.221436901462551 0.0965904764063157 3.40477771423069 4.66292028528871e-38 miRanda -0.269631711475672 0.00393867817049135 NA NA NA hsa-miR-141-3p CXCL12 0.730011517758706 0.000120338355004032 -1.76724475752711 4.01929501727072e-11 miRNATAP -0.687816710327647 9.04660888438558e-32 NA NA NA hsa-miR-16-2-3p CXCL12 1.1567130855258 1.01867256952189e-14 -1.76724475752711 4.01929501727072e-11 mirMAP -0.602214969393292 1.64744901385104e-15 NA NA NA hsa-miR-200a-3p CXCL12 0.607140814457753 0.00289840524858752 -1.76724475752711 4.01929501727072e-11 miRNATAP -0.577727019089135 2.14744079778771e-25 NA NA NA hsa-miR-221-3p CXCL12 0.410625614724387 0.000741090075261272 -1.76724475752711 4.01929501727072e-11 MirTarget -0.596580253675093 6.19377751191056e-10 NA NA NA hsa-miR-222-3p CXCL12 1.08197052578759 2.32604040301699e-14 -1.76724475752711 4.01929501727072e-11 MirTarget -0.749379798434986 1.9853676607573e-21 NA NA NA hsa-miR-23a-3p CXCL12 0.348231698801568 6.4911858506572e-05 -1.76724475752711 4.01929501727072e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.686113632480438 4.80519914908084e-07 25322765 MiR-23a suppressed the transcription of RUNX2 and CXCL12 by binding to the 3' UTRs of these mRNAs; The cellular function of miR-23a is RUNX2/CXCL12-dependent and the overexpression of RUNX2 or CXCL12 rescued the impaired cell growth migration and invasion induced by miR-23a sarcoma hsa-miR-301a-3p CXCL12 2.14132004241926 4.46255413526808e-25 -1.76724475752711 4.01929501727072e-11 miRNATAP -0.460860429280853 3.33654008813133e-18 NA NA NA hsa-miR-31-5p CXCL12 2.79079137807505 1.72181058015659e-13 -1.76724475752711 4.01929501727072e-11 miRNAWalker2_validate -0.257967639344668 8.26846164270146e-18 NA NA NA hsa-miR-320a CXCL12 0.801356001806321 4.91397101474502e-09 -1.76724475752711 4.01929501727072e-11 miRanda -0.29174778655099 0.000662395470671132 NA NA NA hsa-miR-320b CXCL12 1.23473838180754 3.04337566045537e-14 -1.76724475752711 4.01929501727072e-11 miRanda -0.375327710019773 1.1137850956327e-07 NA NA NA hsa-miR-429 CXCL12 0.559451508722375 0.00563641638673083 -1.76724475752711 4.01929501727072e-11 miRanda;miRNATAP -0.552515734310567 1.00253459008207e-22 NA NA NA hsa-miR-455-5p CXCL12 1.408595672323 5.52039116456697e-22 -1.76724475752711 4.01929501727072e-11 miRanda -0.49581903175339 1.17925868995932e-10 NA NA NA hsa-miR-590-3p CXCL12 0.221436901462551 0.0965904764063157 -1.76724475752711 4.01929501727072e-11 PITA;miRanda;mirMAP -0.239731200362022 0.00748542875411205 NA NA NA hsa-miR-629-3p CXCL12 1.43262037314105 2.37092217984413e-19 -1.76724475752711 4.01929501727072e-11 MirTarget -0.459658581628038 9.60944150255338e-11 NA NA NA hsa-miR-96-5p CXCL12 1.42326703011157 4.39736150032373e-14 -1.76724475752711 4.01929501727072e-11 mirMAP -0.639740794074251 5.66405789678276e-28 NA NA NA hsa-miR-1-3p CXCL6 -3.74089429869761 3.30962366504583e-11 0.36645146342366 0.369042050309467 MirTarget -0.120217662499222 9.15963117068914e-05 NA NA NA hsa-miR-155-5p CYR61 0.533437622040649 0.00248671179205372 -0.567354951819466 0.00417908418096135 miRNAWalker2_validate;miRTarBase -0.167937445498313 0.000589988963654811 NA NA NA hsa-miR-205-5p CYR61 1.50759485376634 2.0003886738248e-16 -0.567354951819466 0.00417908418096135 miRNAWalker2_validate;miRTarBase -0.309514432970293 5.71669664259022e-12 NA NA NA hsa-miR-331-5p CYR61 0.851618030062133 1.42670149420057e-14 -0.567354951819466 0.00417908418096135 miRNATAP -0.326247218267357 1.89096211204331e-05 NA NA NA hsa-miR-429 CYR61 0.559451508722375 0.00563641638673083 -0.567354951819466 0.00417908418096135 miRanda -0.31194285456103 7.95224092934955e-14 NA NA NA hsa-miR-944 CYR61 1.47323925060177 2.61626403984929e-13 -0.567354951819466 0.00417908418096135 PITA;mirMAP;miRNATAP -0.229979676768431 2.94754268998741e-08 NA NA NA hsa-miR-106a-5p DAB2 0.67978010057847 0.00221925869726092 -0.0877236005782827 0.637564761172262 MirTarget;miRNATAP -0.221035624437351 6.72563787092463e-10 NA NA NA hsa-miR-106b-5p DAB2 0.50378717276868 1.45412404526866e-05 -0.0877236005782827 0.637564761172262 MirTarget;miRNATAP -0.3045267610945 1.09758232438525e-05 26769181 The expression of the miR-106b target gene DAB2 in human cervical tissues and cell lines were measured by qRT-PCR western blot and immunohistochemistry; DAB2 a predicted target gene of miR-106b was inhibited by TGF-β1 partly through miR-106b and was involved in TGF-β1-induced cervical cancer cell migration; The expression of DAB2 was low in cervical cancer tissues and negatively correlated with miR-106b expression cell migration cervical and endocervical cancer hsa-miR-149-5p DAB2 0.443278770827687 0.0642022866136881 -0.0877236005782827 0.637564761172262 miRNATAP -0.29353831347543 2.41232227188001e-19 NA NA NA hsa-miR-17-5p DAB2 1.41924888736771 2.75805544953758e-18 -0.0877236005782827 0.637564761172262 MirTarget;TargetScan;miRNATAP -0.507995548697392 8.44024428665461e-29 NA NA NA hsa-miR-186-5p DAB2 0.353452958261612 0.000145058448579496 -0.0877236005782827 0.637564761172262 MirTarget;mirMAP -0.228809514886504 0.00906442762235365 NA NA NA hsa-miR-203a-3p DAB2 0.0441399794719697 0.880456392176704 -0.0877236005782827 0.637564761172262 MirTarget -0.291260333023938 7.41437989619021e-29 NA NA NA hsa-miR-20a-5p DAB2 1.1531986665452 1.02385132917958e-11 -0.0877236005782827 0.637564761172262 MirTarget;miRNATAP -0.487684083106525 5.59729103960917e-28 NA NA NA hsa-miR-20b-5p DAB2 0.345967670847176 0.232014828043601 -0.0877236005782827 0.637564761172262 MirTarget;miRNATAP -0.11758283550049 2.43733832825416e-05 NA NA NA hsa-miR-26b-5p DAB2 -0.254478038884324 0.0285227763044636 -0.0877236005782827 0.637564761172262 miRNAWalker2_validate -0.288801263018002 3.51044586653826e-05 NA NA NA hsa-miR-320a DAB2 0.801356001806321 4.91397101474502e-09 -0.0877236005782827 0.637564761172262 PITA;miRanda;miRNATAP -0.276451683224661 1.93204601426359e-06 NA NA NA hsa-miR-320b DAB2 1.23473838180754 3.04337566045537e-14 -0.0877236005782827 0.637564761172262 PITA;miRanda;miRNATAP -0.21873906745578 6.09171989925859e-06 NA NA NA hsa-miR-331-5p DAB2 0.851618030062133 1.42670149420057e-14 -0.0877236005782827 0.637564761172262 PITA -0.421627053873382 2.65615901242483e-09 NA NA NA hsa-miR-339-5p DAB2 1.07771430326938 2.45772601859307e-09 -0.0877236005782827 0.637564761172262 miRanda -0.341050529788499 2.32310663149573e-15 NA NA NA hsa-miR-532-3p DAB2 0.80240056676907 1.08989551712617e-09 -0.0877236005782827 0.637564761172262 PITA -0.258491651886488 1.9375311616199e-05 NA NA NA hsa-miR-590-3p DAB2 0.221436901462551 0.0965904764063157 -0.0877236005782827 0.637564761172262 miRanda;mirMAP -0.219924909158608 0.000304628078629809 NA NA NA hsa-miR-590-5p DAB2 0.763025362395968 3.65305892505623e-09 -0.0877236005782827 0.637564761172262 miRanda -0.511560130663851 1.72607925744135e-17 NA NA NA hsa-miR-93-5p DAB2 1.61042951896619 5.1280369606967e-24 -0.0877236005782827 0.637564761172262 MirTarget;miRNATAP -0.396566485143967 4.38814930048124e-17 24037530 miR 93 directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer; We next identify that microRNA miR-93 functions as a potent repressor of DAB2 expression by directly targeting the 3'UTR of the DAB2 mRNA; Using in vitro and in vivo approaches we demonstrate that miR-93 overexpression has an important role in promoting lung cancer cell growth and that its oncogenic function is primarily mediated by downregulating DAB2 expression; The correlations of both low DAB2 and high miR-93 expression levels with poor patient survival strongly support the critical role of the miR-93/DAB2 pathway in determining lung cancer progression progression;poor survival lung cancer hsa-miR-96-5p DAB2 1.42326703011157 4.39736150032373e-14 -0.0877236005782827 0.637564761172262 MirTarget;TargetScan -0.398518241609291 3.24115415181809e-23 NA NA NA hsa-let-7d-5p DCN 0.481757661442508 3.66030810124939e-07 -0.638949417374653 0.0055000689724149 MirTarget -0.475410164408476 6.61813507352637e-06 NA NA NA hsa-miR-142-5p DCN 0.288897753038094 0.0900009317815725 -0.638949417374653 0.0055000689724149 mirMAP -0.164710662674843 0.00529968920525038 NA NA NA hsa-miR-186-5p DCN 0.353452958261612 0.000145058448579496 -0.638949417374653 0.0055000689724149 mirMAP -0.485911549773797 6.95425342377756e-06 NA NA NA hsa-miR-320a DCN 0.801356001806321 4.91397101474502e-09 -0.638949417374653 0.0055000689724149 miRanda -0.372244185670233 2.26509375147898e-07 NA NA NA hsa-miR-320b DCN 1.23473838180754 3.04337566045537e-14 -0.638949417374653 0.0055000689724149 miRanda -0.277865761239286 3.60418507248829e-06 NA NA NA hsa-miR-342-3p DCN 0.99756868977753 9.28499866272332e-10 -0.638949417374653 0.0055000689724149 miRanda -0.277524260786085 4.33215806746591e-06 NA NA NA hsa-miR-501-5p DCN 1.02806906860218 1.63456814370548e-09 -0.638949417374653 0.0055000689724149 mirMAP -0.206176427375195 0.000452383194150501 NA NA NA hsa-miR-590-3p DCN 0.221436901462551 0.0965904764063157 -0.638949417374653 0.0055000689724149 MirTarget;PITA;miRanda;mirMAP -0.408326963958745 5.12879132756055e-08 NA NA NA hsa-miR-7-1-3p DCN 1.13646121619622 1.49823237535933e-14 -0.638949417374653 0.0055000689724149 mirMAP -0.530833495737242 1.95587740082491e-16 NA NA NA hsa-miR-944 DCN 1.47323925060177 2.61626403984929e-13 -0.638949417374653 0.0055000689724149 mirMAP -0.18943521829371 9.5486448865568e-05 NA NA NA hsa-miR-141-3p DPYSL3 0.730011517758706 0.000120338355004032 -0.382047973233933 0.100789463830135 TargetScan -0.331220856544658 2.50175127751977e-10 NA NA NA hsa-miR-197-3p DPYSL3 0.878693269130833 3.84847526014135e-15 -0.382047973233933 0.100789463830135 miRNAWalker2_validate -0.268382806930012 0.00250939794835875 NA NA NA hsa-miR-2355-5p DPYSL3 1.47205546931107 8.65192179636668e-19 -0.382047973233933 0.100789463830135 MirTarget -0.293804991237203 5.02748594784818e-07 NA NA NA hsa-miR-26b-5p DPYSL3 -0.254478038884324 0.0285227763044636 -0.382047973233933 0.100789463830135 miRNAWalker2_validate -0.261972434383477 0.00282899522723414 NA NA NA hsa-miR-29b-3p DPYSL3 -0.110721443686039 0.511264554091106 -0.382047973233933 0.100789463830135 MirTarget -0.192843190841508 0.00137589145841067 NA NA NA hsa-miR-31-3p DPYSL3 2.10124531535908 1.70135756565194e-08 -0.382047973233933 0.100789463830135 MirTarget -0.177078960999154 1.83314660846972e-11 NA NA NA hsa-miR-423-3p DPYSL3 1.20230884409188 2.57129723627633e-23 -0.382047973233933 0.100789463830135 miRNAWalker2_validate -0.353806884910066 1.02947633704482e-05 NA NA NA hsa-miR-106a-5p DST 0.67978010057847 0.00221925869726092 0.143511786087913 0.3927294322949 mirMAP -0.141685618491526 1.37641350664464e-05 NA NA NA hsa-miR-125a-5p DST 0.215366061934933 0.119550904549401 0.143511786087913 0.3927294322949 mirMAP -0.147636132542802 0.00535531671021869 NA NA NA hsa-miR-130b-5p DST 1.77265255049999 1.43627774829684e-29 0.143511786087913 0.3927294322949 mirMAP -0.146413619802205 0.000858185866016557 NA NA NA hsa-miR-141-3p DST 0.730011517758706 0.000120338355004032 0.143511786087913 0.3927294322949 mirMAP -0.146844085477968 0.000118976709530297 NA NA NA hsa-miR-149-5p DST 0.443278770827687 0.0642022866136881 0.143511786087913 0.3927294322949 mirMAP -0.100415645059079 0.000965626853722002 NA NA NA hsa-miR-16-1-3p DST 0.955017760172879 5.95379292601146e-11 0.143511786087913 0.3927294322949 mirMAP -0.140090823278913 0.00454260448687838 NA NA NA hsa-miR-16-2-3p DST 1.1567130855258 1.01867256952189e-14 0.143511786087913 0.3927294322949 mirMAP -0.137354115650311 0.00396797760720071 NA NA NA hsa-miR-17-5p DST 1.41924888736771 2.75805544953758e-18 0.143511786087913 0.3927294322949 mirMAP -0.159003245657346 0.000242823972258738 NA NA NA hsa-miR-186-5p DST 0.353452958261612 0.000145058448579496 0.143511786087913 0.3927294322949 mirMAP -0.271909640752958 0.00056634743011219 NA NA NA hsa-miR-18a-5p DST 1.65455873230328 3.76457892277775e-20 0.143511786087913 0.3927294322949 mirMAP -0.116220084377553 0.00294353334383751 NA NA NA hsa-miR-192-5p DST 0.380924502586635 0.00986961967409205 0.143511786087913 0.3927294322949 miRNAWalker2_validate;mirMAP -0.253383814069422 2.46008713079359e-07 NA NA NA hsa-miR-19b-1-5p DST 0.757034032029085 2.99828133413343e-07 0.143511786087913 0.3927294322949 mirMAP -0.138629272035964 0.00469390899796023 NA NA NA hsa-miR-200a-3p DST 0.607140814457753 0.00289840524858752 0.143511786087913 0.3927294322949 mirMAP -0.135142786784659 0.000148601549496604 NA NA NA hsa-miR-200b-3p DST 0.0717138787925347 0.682858087587209 0.143511786087913 0.3927294322949 mirMAP -0.140066448892311 0.000771993912328503 NA NA NA hsa-miR-20a-3p DST 1.34885093664027 2.07697464119202e-12 0.143511786087913 0.3927294322949 mirMAP -0.109817160055643 0.00319237562006017 NA NA NA hsa-miR-20a-5p DST 1.1531986665452 1.02385132917958e-11 0.143511786087913 0.3927294322949 mirMAP -0.177517081390699 2.45904602546263e-05 NA NA NA hsa-miR-20b-5p DST 0.345967670847176 0.232014828043601 0.143511786087913 0.3927294322949 mirMAP -0.137153142212518 3.99146927643862e-08 NA NA NA hsa-miR-218-5p DST -1.0725338636959 3.61493686604269e-09 0.143511786087913 0.3927294322949 miRNAWalker2_validate;mirMAP -0.122747766728394 0.00193201832786218 NA NA NA hsa-miR-25-3p DST 0.76549796417801 3.32282098247097e-11 0.143511786087913 0.3927294322949 mirMAP -0.355327722118191 8.55758568010614e-09 NA NA NA hsa-miR-26b-5p DST -0.254478038884324 0.0285227763044636 0.143511786087913 0.3927294322949 mirMAP;miRNATAP -0.230753410114688 0.000252802997084063 NA NA NA hsa-miR-3065-3p DST -0.543069092777161 0.0213164885178151 0.143511786087913 0.3927294322949 mirMAP -0.17782084603288 5.74489570489449e-09 NA NA NA hsa-miR-30d-3p DST -0.577371911152798 2.02950840095287e-06 0.143511786087913 0.3927294322949 mirMAP -0.25891641760627 1.44186011933581e-05 NA NA NA hsa-miR-3127-5p DST 0.706677736144125 1.91821443636366e-05 0.143511786087913 0.3927294322949 mirMAP -0.115011270357959 0.00888621333825017 NA NA NA hsa-miR-320a DST 0.801356001806321 4.91397101474502e-09 0.143511786087913 0.3927294322949 mirMAP -0.222957958697583 2.15692432204225e-05 NA NA NA hsa-miR-335-3p DST 0.336785882180547 0.0542446207938138 0.143511786087913 0.3927294322949 mirMAP -0.140528312768639 0.0007554729432468 NA NA NA hsa-miR-335-5p DST -1.17227779671552 1.49282618530733e-10 0.143511786087913 0.3927294322949 miRNAWalker2_validate -0.118796999255311 0.00244952249754775 NA NA NA hsa-miR-362-5p DST 0.41089772861323 0.0404254902071382 0.143511786087913 0.3927294322949 TargetScan;mirMAP -0.227732445500377 2.14853756149014e-10 NA NA NA hsa-miR-363-3p DST -0.608157508016978 0.0186109501272176 0.143511786087913 0.3927294322949 mirMAP -0.119706655376139 1.99266447478992e-05 NA NA NA hsa-miR-429 DST 0.559451508722375 0.00563641638673083 0.143511786087913 0.3927294322949 miRanda;mirMAP;miRNATAP -0.145621845501347 5.04057461925841e-05 NA NA NA hsa-miR-500a-3p DST 0.457959128173392 0.000691656736597067 0.143511786087913 0.3927294322949 mirMAP -0.362827399612834 8.55298973604124e-12 NA NA NA hsa-miR-505-3p DST 0.912823669571645 4.0549774967148e-13 0.143511786087913 0.3927294322949 mirMAP -0.226708860770085 6.49610261646319e-05 NA NA NA hsa-miR-532-3p DST 0.80240056676907 1.08989551712617e-09 0.143511786087913 0.3927294322949 mirMAP -0.154994232904552 0.0047048252649084 NA NA NA hsa-miR-532-5p DST -0.021857649390892 0.830992272120134 0.143511786087913 0.3927294322949 mirMAP -0.295609615022343 3.82597282524529e-05 NA NA NA hsa-miR-550a-5p DST 1.48775474412835 6.14204462566372e-18 0.143511786087913 0.3927294322949 mirMAP -0.112069984279095 0.00630512628447213 NA NA NA hsa-miR-590-5p DST 0.763025362395968 3.65305892505623e-09 0.143511786087913 0.3927294322949 mirMAP -0.18285038851022 0.00105163863177293 NA NA NA hsa-miR-664a-3p DST -0.256108763664991 0.0513188660751664 0.143511786087913 0.3927294322949 mirMAP -0.165763760744318 0.00296437065629022 NA NA NA hsa-miR-769-3p DST 0.89886491506181 2.21711828717073e-08 0.143511786087913 0.3927294322949 mirMAP -0.117006367236041 0.0098607173624841 NA NA NA hsa-miR-9-5p DST 1.65694862043766 2.08325802567323e-05 0.143511786087913 0.3927294322949 mirMAP -0.12930044876788 1.26689699721585e-12 NA NA NA hsa-miR-92a-3p DST 0.994679542307232 1.32587679156217e-16 0.143511786087913 0.3927294322949 mirMAP -0.255522650004703 1.44568973880954e-05 NA NA NA hsa-miR-93-5p DST 1.61042951896619 5.1280369606967e-24 0.143511786087913 0.3927294322949 mirMAP -0.198113008931513 5.46793470410539e-06 NA NA NA hsa-miR-142-3p ECM2 1.12754191614028 1.68798138028946e-08 -0.0987562719049655 0.625269640093516 miRanda;miRNATAP -0.202875498233796 2.55673782835343e-06 NA NA NA hsa-miR-16-2-3p ECM2 1.1567130855258 1.01867256952189e-14 -0.0987562719049655 0.625269640093516 mirMAP -0.571485845666705 1.72762938780106e-25 NA NA NA hsa-miR-205-3p ECM2 1.2960640797621 5.80786479909147e-11 -0.0987562719049655 0.625269640093516 MirTarget -0.435788026959313 1.08355187214905e-25 NA NA NA hsa-miR-30d-3p ECM2 -0.577371911152798 2.02950840095287e-06 -0.0987562719049655 0.625269640093516 MirTarget -0.532239280997113 4.77757341870983e-14 NA NA NA hsa-miR-320a ECM2 0.801356001806321 4.91397101474502e-09 -0.0987562719049655 0.625269640093516 miRanda -0.315911498871312 5.31030220176389e-07 NA NA NA hsa-miR-320b ECM2 1.23473838180754 3.04337566045537e-14 -0.0987562719049655 0.625269640093516 miRanda -0.241092966744706 4.39580907270064e-06 NA NA NA hsa-miR-331-5p ECM2 0.851618030062133 1.42670149420057e-14 -0.0987562719049655 0.625269640093516 MirTarget -0.384389443659061 6.67463089270738e-07 NA NA NA hsa-miR-335-3p ECM2 0.336785882180547 0.0542446207938138 -0.0987562719049655 0.625269640093516 MirTarget -0.256786323947459 2.63087866281396e-07 NA NA NA hsa-miR-342-3p ECM2 0.99756868977753 9.28499866272332e-10 -0.0987562719049655 0.625269640093516 miRanda -0.194107069487603 0.000254154545700893 NA NA NA hsa-miR-452-3p ECM2 1.09618110917892 2.21867884261816e-07 -0.0987562719049655 0.625269640093516 MirTarget -0.221682016679591 5.03170222283499e-08 NA NA NA hsa-miR-590-3p ECM2 0.221436901462551 0.0965904764063157 -0.0987562719049655 0.625269640093516 MirTarget;miRanda;miRNATAP -0.32545191958087 7.51442504535592e-07 NA NA NA hsa-miR-590-5p ECM2 0.763025362395968 3.65305892505623e-09 -0.0987562719049655 0.625269640093516 miRanda -0.608408640096162 6.07306904598565e-21 NA NA NA hsa-miR-7-1-3p ECM2 1.13646121619622 1.49823237535933e-14 -0.0987562719049655 0.625269640093516 MirTarget -0.459648268189181 4.27295486017668e-16 NA NA NA hsa-miR-944 ECM2 1.47323925060177 2.61626403984929e-13 -0.0987562719049655 0.625269640093516 mirMAP -0.199685629338925 2.4220848330663e-06 NA NA NA hsa-let-7a-3p EDIL3 0.0966652362351867 0.423761916840503 0.287634634637161 0.453425090303625 MirTarget -0.622342461411391 6.86925288221244e-06 NA NA NA hsa-miR-16-2-3p EDIL3 1.1567130855258 1.01867256952189e-14 0.287634634637161 0.453425090303625 mirMAP -1.0003630373454 1.41975670288557e-21 NA NA NA hsa-miR-186-5p EDIL3 0.353452958261612 0.000145058448579496 0.287634634637161 0.453425090303625 mirMAP -1.3967445485376 2.12574517016269e-15 NA NA NA hsa-miR-29b-1-5p EDIL3 1.39669186711325 4.36960953138935e-11 0.287634634637161 0.453425090303625 MirTarget -0.59294542574016 4.12078277946663e-15 NA NA NA hsa-miR-374a-3p EDIL3 -0.299190081500425 0.00682975596757891 0.287634634637161 0.453425090303625 MirTarget -0.635694389549309 2.59816534296412e-05 NA NA NA hsa-miR-374b-5p EDIL3 -0.288413933608091 0.0041474558664058 0.287634634637161 0.453425090303625 mirMAP -0.741716665423881 8.16800151551412e-06 NA NA NA hsa-miR-425-5p EDIL3 0.931027421598738 6.46235724408844e-08 0.287634634637161 0.453425090303625 MirTarget -0.52781341396425 2.63000786251656e-08 NA NA NA hsa-miR-501-5p EDIL3 1.02806906860218 1.63456814370548e-09 0.287634634637161 0.453425090303625 mirMAP -0.550071316782078 1.30981213222727e-08 NA NA NA hsa-miR-590-3p EDIL3 0.221436901462551 0.0965904764063157 0.287634634637161 0.453425090303625 miRanda;mirMAP -0.689501768306464 3.07720820043443e-08 NA NA NA hsa-miR-590-5p EDIL3 0.763025362395968 3.65305892505623e-09 0.287634634637161 0.453425090303625 MirTarget;miRNATAP -0.88533465821297 1.57136265333641e-12 NA NA NA hsa-miR-7-1-3p EDIL3 1.13646121619622 1.49823237535933e-14 0.287634634637161 0.453425090303625 MirTarget -0.833163287748607 9.97611866518756e-15 NA NA NA hsa-miR-324-3p EFEMP2 0.867391246413545 3.63808540490361e-10 0.128781708784983 0.514544555867467 MirTarget -0.181750051374651 0.00301136626138594 NA NA NA hsa-miR-330-5p EFEMP2 0.944693925383906 5.04972895657346e-13 0.128781708784983 0.514544555867467 miRanda -0.195563961403859 0.00241689194666787 NA NA NA hsa-miR-629-3p EFEMP2 1.43262037314105 2.37092217984413e-19 0.128781708784983 0.514544555867467 MirTarget -0.343038151953553 2.23335402303357e-11 NA NA NA hsa-miR-29b-3p ELN -0.110721443686039 0.511264554091106 -1.52812562365078 7.19561298851408e-06 MirTarget;miRNATAP -0.314493636433055 0.000398519599835293 NA NA NA hsa-miR-331-3p ELN 0.906385914819361 4.27653809739414e-11 -1.52812562365078 7.19561298851408e-06 MirTarget;PITA -0.388276032156344 0.000281492098923315 NA NA NA hsa-miR-3614-5p ELN 0.955957969488529 2.95347675446694e-05 -1.52812562365078 7.19561298851408e-06 mirMAP -0.331686604662894 2.58430837399081e-07 NA NA NA hsa-miR-429 ELN 0.559451508722375 0.00563641638673083 -1.52812562365078 7.19561298851408e-06 miRNATAP -0.248557199476469 0.000752112456278853 NA NA NA hsa-miR-939-5p ELN 1.00479167005165 2.93105661166695e-09 -1.52812562365078 7.19561298851408e-06 MirTarget -0.474162772853894 1.87223428556949e-07 NA NA NA hsa-miR-338-3p ENO2 -0.948755228846395 8.99167125682392e-08 2.24439019929173 3.59147813561171e-24 miRanda -0.280224306936642 5.23388148687065e-07 NA NA NA hsa-miR-30a-5p FAP -1.79779915425811 1.93360169837799e-26 3.05741840345564 7.04689490017445e-28 miRNATAP -0.301990639938834 2.76732673182413e-05 NA NA NA hsa-miR-30c-5p FAP 0.021222006155897 0.886366656528128 3.05741840345564 7.04689490017445e-28 miRNATAP -0.350671597180089 5.13960094271188e-05 NA NA NA hsa-miR-30d-5p FAP -0.38399848121878 0.000171129616944749 3.05741840345564 7.04689490017445e-28 miRNATAP -0.949686884790049 1.34249283042522e-14 NA NA NA hsa-miR-338-5p FAP -1.71946558699173 2.62649071488641e-23 3.05741840345564 7.04689490017445e-28 PITA;miRNATAP -0.257791940740407 0.000283079391840262 NA NA NA hsa-miR-375 FAP -4.24070205340868 7.48368361454041e-28 3.05741840345564 7.04689490017445e-28 miRanda -0.299294165888794 2.11086895062894e-23 NA NA NA hsa-miR-429 FAP 0.559451508722375 0.00563641638673083 3.05741840345564 7.04689490017445e-28 miRNATAP -0.459186748697505 1.41946056853004e-13 NA NA NA hsa-miR-361-5p FAS 0.0803683277369505 0.314043140368058 -0.353746390296431 0.0224836395610983 miRanda -0.254638067114056 0.00313062697979385 NA NA NA hsa-miR-590-5p FAS 0.763025362395968 3.65305892505623e-09 -0.353746390296431 0.0224836395610983 miRanda -0.179002441556527 0.000520949899474374 NA NA NA hsa-miR-193a-3p FBLN1 0.22120710726779 0.111827069464729 -0.0246183592386782 0.894817881698269 miRanda -0.290426186587102 5.4369133134241e-07 NA NA NA hsa-miR-429 FBLN1 0.559451508722375 0.00563641638673083 -0.0246183592386782 0.894817881698269 miRanda -0.190241964464531 1.65824188523649e-06 NA NA NA hsa-miR-200c-3p FBLN5 0.630251054099546 0.000131975031451555 -0.777835189098198 0.000176368319498701 miRNAWalker2_validate;miRTarBase -0.399089806256503 1.02707942638617e-13 NA NA NA hsa-miR-26b-5p FBLN5 -0.254478038884324 0.0285227763044636 -0.777835189098198 0.000176368319498701 miRNAWalker2_validate -0.258698467550491 0.00098254427663689 NA NA NA hsa-miR-429 FBLN5 0.559451508722375 0.00563641638673083 -0.777835189098198 0.000176368319498701 miRanda;miRNATAP -0.400169252119243 2.11346136658249e-20 NA NA NA hsa-miR-769-5p FBLN5 0.0865819375213306 0.445395188017017 -0.777835189098198 0.000176368319498701 PITA -0.213584018227104 0.00816732224346681 NA NA NA hsa-let-7a-3p FBN1 0.0966652362351867 0.423761916840503 0.642835623035618 0.0172585002325199 mirMAP -0.477101439964144 9.68669231190523e-07 NA NA NA hsa-miR-142-3p FBN1 1.12754191614028 1.68798138028946e-08 0.642835623035618 0.0172585002325199 miRanda -0.258153018755564 8.00001490238633e-06 NA NA NA hsa-miR-16-2-3p FBN1 1.1567130855258 1.01867256952189e-14 0.642835623035618 0.0172585002325199 mirMAP -0.682614784879399 3.44732134786589e-20 NA NA NA hsa-miR-182-5p FBN1 1.15060905311096 6.25565852529946e-10 0.642835623035618 0.0172585002325199 miRNATAP -0.279415261735612 6.43831543294681e-06 NA NA NA hsa-miR-188-5p FBN1 0.559328953885106 0.000430338888594543 0.642835623035618 0.0172585002325199 PITA -0.235331682354939 0.00151662636416406 NA NA NA hsa-miR-192-5p FBN1 0.380924502586635 0.00986961967409205 0.642835623035618 0.0172585002325199 miRNAWalker2_validate -0.245720476760048 0.00208279006648966 NA NA NA hsa-miR-19b-1-5p FBN1 0.757034032029085 2.99828133413343e-07 0.642835623035618 0.0172585002325199 mirMAP -0.632266962851258 1.94248021763485e-16 NA NA NA hsa-miR-25-3p FBN1 0.76549796417801 3.32282098247097e-11 0.642835623035618 0.0172585002325199 mirMAP -0.386995443818435 0.000115945218561314 NA NA NA hsa-miR-29b-3p FBN1 -0.110721443686039 0.511264554091106 0.642835623035618 0.0172585002325199 miRNATAP -0.57241209832461 3.91924397668599e-17 NA NA NA hsa-miR-362-3p FBN1 -0.697212068252854 2.61718493418184e-06 0.642835623035618 0.0172585002325199 miRanda;miRNATAP -0.31868192810608 5.36698244826542e-05 NA NA NA hsa-miR-363-3p FBN1 -0.608157508016978 0.0186109501272176 0.642835623035618 0.0172585002325199 mirMAP -0.2040766963307 6.3527473988436e-06 NA NA NA hsa-miR-375 FBN1 -4.24070205340868 7.48368361454041e-28 0.642835623035618 0.0172585002325199 mirMAP -0.119268869750351 3.02088795955666e-05 NA NA NA hsa-miR-429 FBN1 0.559451508722375 0.00563641638673083 0.642835623035618 0.0172585002325199 miRNATAP -0.54336908002168 2.20008647819347e-22 NA NA NA hsa-miR-576-5p FBN1 0.940432050128373 6.90227595663302e-12 0.642835623035618 0.0172585002325199 mirMAP -0.534198021876914 1.31068545098042e-10 NA NA NA hsa-miR-582-5p FBN1 -0.0366995972742474 0.821827119138923 0.642835623035618 0.0172585002325199 miRNATAP -0.598374106146116 1.78353187366765e-17 NA NA NA hsa-miR-590-3p FBN1 0.221436901462551 0.0965904764063157 0.642835623035618 0.0172585002325199 miRanda;mirMAP -0.500139426739478 1.19879121232663e-08 NA NA NA hsa-miR-92a-3p FBN1 0.994679542307232 1.32587679156217e-16 0.642835623035618 0.0172585002325199 mirMAP -0.751928473774555 5.94587647047415e-16 NA NA NA hsa-miR-944 FBN1 1.47323925060177 2.61626403984929e-13 0.642835623035618 0.0172585002325199 PITA;mirMAP -0.172955971594903 0.00243961417546059 NA NA NA hsa-miR-101-3p FBN2 -1.91263766544878 1.50270129259053e-39 2.90843390985456 1.08565166425739e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.583539283736707 4.00761233097968e-08 NA NA NA hsa-miR-139-5p FBN2 -1.46099200329485 7.85040381494472e-22 2.90843390985456 1.08565166425739e-14 MirTarget;PITA;miRanda;miRNATAP -0.289250246169302 0.0065896584446228 NA NA NA hsa-miR-140-3p FBN2 -0.967453553824782 7.6999446305445e-23 2.90843390985456 1.08565166425739e-14 PITA -0.501654897810075 0.0024248931088194 NA NA NA hsa-miR-335-5p FBN2 -1.17227779671552 1.49282618530733e-10 2.90843390985456 1.08565166425739e-14 miRNAWalker2_validate -0.264730189906915 0.00343174406748107 NA NA NA hsa-miR-338-5p FBN2 -1.71946558699173 2.62649071488641e-23 2.90843390985456 1.08565166425739e-14 mirMAP -0.376624307387805 5.03230729784367e-05 NA NA NA hsa-miR-375 FBN2 -4.24070205340868 7.48368361454041e-28 2.90843390985456 1.08565166425739e-14 miRanda -0.23916132413906 3.69043193413753e-09 NA NA NA hsa-miR-582-3p FBN2 -0.248056267546012 0.143798829508405 2.90843390985456 1.08565166425739e-14 PITA;miRNATAP -0.362797554157373 0.00025538334483012 NA NA NA hsa-miR-103a-3p FERMT2 0.556219385347418 1.55815736455067e-09 -0.0401732207913552 0.839312966451133 MirTarget -0.248154322473287 0.00777370059414727 NA NA NA hsa-miR-15a-5p FERMT2 0.783550182002274 2.60699595655907e-11 -0.0401732207913552 0.839312966451133 MirTarget;miRNATAP -0.436486302174144 9.45591085232903e-10 NA NA NA hsa-miR-15b-5p FERMT2 0.85315666454713 3.79816274836297e-12 -0.0401732207913552 0.839312966451133 MirTarget;miRNATAP -0.384261169625653 1.80528631343437e-08 NA NA NA hsa-miR-16-5p FERMT2 0.521122945828175 1.40561786410572e-06 -0.0401732207913552 0.839312966451133 MirTarget;miRNATAP -0.4765754322507 1.30871220990092e-09 NA NA NA hsa-miR-200b-3p FERMT2 0.0717138787925347 0.682858087587209 -0.0401732207913552 0.839312966451133 TargetScan -0.467546547677342 3.71985523572249e-23 23483548;24064224;26334393 Here we report that Kindlin 2 markedly downregulates the expression of miR-200 family by inducing CpG island hypermethylation; Our data indicate that Kindlin 2 plays a novel role in epigenetic repression of miR-200 family a mechanism that promotes breast cancer invasion;miR 200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin 2; Quantitative mass spectrometry identified 57 putative miR-200b targets including Kindlin-2 previously implicated in the regulation of tumor invasiveness and actin cytoskeleton in other cell types; Enforced expression of miR-200b mimic in ESCC cells led to a decrease of Kindlin-2 expression whereas transfection of miR-200b inhibitor induced Kindlin-2 expression; Furthermore transfection of miR-200b mimic or knockdown of Kindlin-2 in ESCC cells decreased cell protrusion and focal adhesion FA formation reduced cell spreading and invasiveness/migration; Enforced expression of Kindlin-2 largely abrogated the inhibitory effects of miR-200b on ESCC cell invasiveness; The tumor suppressor effects of miR-200b may be due to its suppression of Kindlin-2 a novel target of miR-200b that modulates actin cytoskeleton FA formation and the migratory/invasiveness properties of ESCC;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ;; breast cancer;esophageal cancer;esophageal cancer hsa-miR-205-5p FERMT2 1.50759485376634 2.0003886738248e-16 -0.0401732207913552 0.839312966451133 miRNATAP -0.498145253736544 5.04144924315008e-31 NA NA NA hsa-miR-221-3p FERMT2 0.410625614724387 0.000741090075261272 -0.0401732207913552 0.839312966451133 MirTarget;miRNATAP -0.48299268950025 3.90158064033566e-12 NA NA NA hsa-miR-222-3p FERMT2 1.08197052578759 2.32604040301699e-14 -0.0401732207913552 0.839312966451133 MirTarget;miRNATAP -0.454815968656812 4.07193014615523e-15 NA NA NA hsa-miR-29b-3p FERMT2 -0.110721443686039 0.511264554091106 -0.0401732207913552 0.839312966451133 MirTarget;miRNATAP -0.29204292598994 8.15685204361428e-09 NA NA NA hsa-miR-30b-5p FERMT2 -0.400238605368173 0.00346540992719245 -0.0401732207913552 0.839312966451133 miRNAWalker2_validate -0.241115703851526 0.000123807885576488 NA NA NA hsa-miR-429 FERMT2 0.559451508722375 0.00563641638673083 -0.0401732207913552 0.839312966451133 miRanda;miRNATAP -0.371041753995702 1.75883751840879e-19 NA NA NA hsa-miR-454-3p FERMT2 1.54137391927201 4.15861570449376e-20 -0.0401732207913552 0.839312966451133 miRNATAP -0.240880609169709 9.37694614547733e-07 NA NA NA hsa-miR-582-3p FERMT2 -0.248056267546012 0.143798829508405 -0.0401732207913552 0.839312966451133 MirTarget;miRNATAP -0.234047375360676 3.66687999270312e-06 NA NA NA hsa-miR-582-5p FERMT2 -0.0366995972742474 0.821827119138923 -0.0401732207913552 0.839312966451133 MirTarget;miRNATAP -0.289107193487657 3.63855105755272e-08 NA NA NA hsa-miR-590-3p FERMT2 0.221436901462551 0.0965904764063157 -0.0401732207913552 0.839312966451133 MirTarget;miRanda;mirMAP;miRNATAP -0.250610804394097 0.000108242562039689 NA NA NA hsa-miR-590-5p FERMT2 0.763025362395968 3.65305892505623e-09 -0.0401732207913552 0.839312966451133 miRanda -0.413570954074695 1.88295729512487e-10 NA NA NA hsa-miR-7-1-3p FERMT2 1.13646121619622 1.49823237535933e-14 -0.0401732207913552 0.839312966451133 mirMAP -0.340857723528282 1.27843224040948e-09 NA NA NA hsa-let-7a-3p FGF2 0.0966652362351867 0.423761916840503 -0.873895268607156 0.000749629544409884 mirMAP -0.346697326213815 0.000235155196874588 NA NA NA hsa-miR-15a-5p FGF2 0.783550182002274 2.60699595655907e-11 -0.873895268607156 0.000749629544409884 MirTarget;miRNATAP -0.337568241456238 0.000380629759701841 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 0.955017760172879 5.95379292601146e-11 -0.873895268607156 0.000749629544409884 mirMAP -0.216053774665656 0.00482669676692554 NA NA NA hsa-miR-19b-1-5p FGF2 0.757034032029085 2.99828133413343e-07 -0.873895268607156 0.000749629544409884 mirMAP -0.299411866060348 7.91846938731196e-05 NA NA NA hsa-miR-20a-3p FGF2 1.34885093664027 2.07697464119202e-12 -0.873895268607156 0.000749629544409884 mirMAP -0.254686140332496 9.5611184793422e-06 NA NA NA hsa-miR-21-3p FGF2 1.25126438776674 2.4124216716282e-17 -0.873895268607156 0.000749629544409884 mirMAP -0.32497551048351 1.17275178306699e-05 NA NA NA hsa-miR-21-5p FGF2 1.62465922021121 3.44191300985109e-58 -0.873895268607156 0.000749629544409884 mirMAP -0.383531284677615 0.000132348473852467 NA NA NA hsa-miR-221-3p FGF2 0.410625614724387 0.000741090075261272 -0.873895268607156 0.000749629544409884 mirMAP -0.449825295563516 1.20603425503909e-06 NA NA NA hsa-miR-222-3p FGF2 1.08197052578759 2.32604040301699e-14 -0.873895268607156 0.000749629544409884 mirMAP -0.480077702405072 4.64663204454521e-10 NA NA NA hsa-miR-424-5p FGF2 1.48125289532143 9.10372985713165e-19 -0.873895268607156 0.000749629544409884 MirTarget;miRNATAP -0.246395124820535 0.000160269078978561 NA NA NA hsa-miR-429 FGF2 0.559451508722375 0.00563641638673083 -0.873895268607156 0.000749629544409884 mirMAP -0.179751399599829 0.00131313676812878 NA NA NA hsa-miR-450b-5p FGF2 1.25529820885833 1.18847120528666e-15 -0.873895268607156 0.000749629544409884 mirMAP -0.227108898055622 0.001244749731088 NA NA NA hsa-miR-452-5p FGF2 0.373288744398455 0.0348485937209964 -0.873895268607156 0.000749629544409884 mirMAP -0.346192872192568 4.93639730457593e-08 NA NA NA hsa-miR-503-5p FGF2 2.85210590411715 1.27298190263569e-35 -0.873895268607156 0.000749629544409884 miRNAWalker2_validate -0.222158187558667 3.87633414352609e-06 NA NA NA hsa-miR-589-3p FGF2 1.59559692667315 6.2886410639161e-15 -0.873895268607156 0.000749629544409884 mirMAP -0.162744204065903 0.00378641086950463 NA NA NA hsa-miR-590-5p FGF2 0.763025362395968 3.65305892505623e-09 -0.873895268607156 0.000749629544409884 miRanda;mirMAP -0.362188154730295 2.75175904757516e-05 NA NA NA hsa-miR-92a-3p FGF2 0.994679542307232 1.32587679156217e-16 -0.873895268607156 0.000749629544409884 miRNAWalker2_validate -0.350572454919679 0.000131198641822221 NA NA NA hsa-miR-944 FGF2 1.47323925060177 2.61626403984929e-13 -0.873895268607156 0.000749629544409884 MirTarget -0.297247292575655 4.68482644368958e-08 NA NA NA hsa-miR-149-5p FLNA 0.443278770827687 0.0642022866136881 0.947112590683666 4.10779218943303e-11 miRNAWalker2_validate -0.193288206448008 9.91458613742898e-14 NA NA NA hsa-miR-200c-3p FLNA 0.630251054099546 0.000131975031451555 0.947112590683666 4.10779218943303e-11 miRNAWalker2_validate -0.123643796665393 0.00129609742511502 NA NA NA hsa-miR-20a-5p FLNA 1.1531986665452 1.02385132917958e-11 0.947112590683666 4.10779218943303e-11 miRNAWalker2_validate -0.166071403154824 5.82686500812721e-06 NA NA NA hsa-miR-23b-3p FLNA -0.497563803223134 3.31483353357535e-05 0.947112590683666 4.10779218943303e-11 miRNAWalker2_validate -0.219502723011033 3.27096444342722e-05 24443580 Kaplan-Meier and multivariate analysis showed a significant association with tumour relapses for miR-23b and with tumour-specific death for miR-150 in PD and oPD thyroid carcinomas thyroid cancer hsa-miR-378a-3p FLNA -1.50453783521372 9.41694954361173e-17 0.947112590683666 4.10779218943303e-11 miRNAWalker2_validate -0.162485536640263 1.63036682652758e-06 NA NA NA hsa-miR-92a-3p FLNA 0.994679542307232 1.32587679156217e-16 0.947112590683666 4.10779218943303e-11 miRNAWalker2_validate -0.187866206849575 0.000264676215032243 NA NA NA hsa-miR-429 FMOD 0.559451508722375 0.00563641638673083 0.255127616070294 0.207486436222454 miRNATAP -0.297476914465911 3.15879349468088e-12 NA NA NA hsa-miR-501-5p FMOD 1.02806906860218 1.63456814370548e-09 0.255127616070294 0.207486436222454 MirTarget -0.136904174442615 0.00805292805607827 NA NA NA hsa-miR-590-5p FMOD 0.763025362395968 3.65305892505623e-09 0.255127616070294 0.207486436222454 miRanda -0.542810160103225 1.15972254358921e-16 NA NA NA hsa-miR-7-1-3p FMOD 1.13646121619622 1.49823237535933e-14 0.255127616070294 0.207486436222454 mirMAP -0.356836685829329 4.94306827329211e-10 NA NA NA hsa-miR-139-5p FN1 -1.46099200329485 7.85040381494472e-22 2.78343880028279 3.22101829842294e-17 miRanda -0.397624297619191 2.04335587806596e-05 NA NA NA hsa-miR-16-1-3p FN1 0.955017760172879 5.95379292601146e-11 2.78343880028279 3.22101829842294e-17 mirMAP -0.344687687792994 0.000578388427387105 NA NA NA hsa-miR-200b-3p FN1 0.0717138787925347 0.682858087587209 2.78343880028279 3.22101829842294e-17 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.85508565290465 3.30241914054747e-26 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-200c-3p FN1 0.630251054099546 0.000131975031451555 2.78343880028279 3.22101829842294e-17 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.52616655899907 2.8116818593274e-09 NA NA NA hsa-miR-26b-5p FN1 -0.254478038884324 0.0285227763044636 2.78343880028279 3.22101829842294e-17 miRNAWalker2_validate -0.698406314760611 3.95140817452624e-08 NA NA NA hsa-miR-27b-3p FN1 -0.732682718863563 2.26896143573324e-09 2.78343880028279 3.22101829842294e-17 MirTarget -0.929284565080484 1.77191082805626e-15 NA NA NA hsa-miR-33a-3p FN1 0.20371038027126 0.212335697664505 2.78343880028279 3.22101829842294e-17 mirMAP -0.50582053448796 3.22008559767904e-08 NA NA NA hsa-miR-429 FN1 0.559451508722375 0.00563641638673083 2.78343880028279 3.22101829842294e-17 MirTarget;PITA;miRanda;miRNATAP -0.586018949436659 1.98632253495529e-16 NA NA NA hsa-miR-590-3p FN1 0.221436901462551 0.0965904764063157 2.78343880028279 3.22101829842294e-17 miRanda;mirMAP -0.413484695477004 0.000210904650356996 NA NA NA hsa-miR-96-5p FN1 1.42326703011157 4.39736150032373e-14 2.78343880028279 3.22101829842294e-17 MirTarget;TargetScan -0.278728253380574 0.000274554771793394 NA NA NA hsa-let-7a-3p FSTL1 0.0966652362351867 0.423761916840503 0.473337980252804 0.0145905313351278 mirMAP -0.301075642352555 1.74511104171102e-05 NA NA NA hsa-let-7f-1-3p FSTL1 0.700374242293247 8.65000484720084e-08 0.473337980252804 0.0145905313351278 mirMAP -0.168401666294865 0.00866042686909268 NA NA NA hsa-miR-101-5p FSTL1 -1.429324744941 4.00032662184937e-18 0.473337980252804 0.0145905313351278 mirMAP -0.149667185031621 0.00258386520447894 NA NA NA hsa-miR-103a-2-5p FSTL1 1.37988337975616 6.74852943995612e-08 0.473337980252804 0.0145905313351278 mirMAP -0.169160647203868 1.68829984205762e-06 NA NA NA hsa-miR-142-5p FSTL1 0.288897753038094 0.0900009317815725 0.473337980252804 0.0145905313351278 PITA;mirMAP -0.207557765846226 2.70856278401253e-05 NA NA NA hsa-miR-149-5p FSTL1 0.443278770827687 0.0642022866136881 0.473337980252804 0.0145905313351278 miRNAWalker2_validate -0.228777787103041 4.15497959889189e-11 NA NA NA hsa-miR-155-5p FSTL1 0.533437622040649 0.00248671179205372 0.473337980252804 0.0145905313351278 miRNAWalker2_validate -0.184649501741973 0.000108123021072387 NA NA NA hsa-miR-18a-3p FSTL1 1.82583720936229 7.51297960972179e-19 0.473337980252804 0.0145905313351278 MirTarget -0.151780470658629 0.000184853546877289 NA NA NA hsa-miR-200b-3p FSTL1 0.0717138787925347 0.682858087587209 0.473337980252804 0.0145905313351278 MirTarget;TargetScan -0.517256471312912 8.75919048217036e-30 NA NA NA hsa-miR-200c-3p FSTL1 0.630251054099546 0.000131975031451555 0.473337980252804 0.0145905313351278 MirTarget -0.376533860469283 4.5448718539233e-14 NA NA NA hsa-miR-203a-3p FSTL1 0.0441399794719697 0.880456392176704 0.473337980252804 0.0145905313351278 MirTarget -0.247922982131118 5.42437899304382e-19 NA NA NA hsa-miR-20a-3p FSTL1 1.34885093664027 2.07697464119202e-12 0.473337980252804 0.0145905313351278 mirMAP -0.214784275056783 5.10713295274338e-07 NA NA NA hsa-miR-24-1-5p FSTL1 -0.0503110566834755 0.742860080224713 0.473337980252804 0.0145905313351278 MirTarget -0.353854450776046 8.06867553163453e-11 NA NA NA hsa-miR-24-2-5p FSTL1 1.27293931700635 4.48240091510596e-15 0.473337980252804 0.0145905313351278 MirTarget -0.159757209445354 0.00162613705309465 NA NA NA hsa-miR-26b-5p FSTL1 -0.254478038884324 0.0285227763044636 0.473337980252804 0.0145905313351278 miRNAWalker2_validate -0.362692691941995 5.81673031988308e-07 NA NA NA hsa-miR-27b-5p FSTL1 0.580870079022649 0.000181529223377382 0.473337980252804 0.0145905313351278 mirMAP -0.476108038286052 1.10396451920343e-19 NA NA NA hsa-miR-29a-5p FSTL1 0.323252792625584 0.0370417231222825 0.473337980252804 0.0145905313351278 mirMAP -0.155826322753874 0.00433587139616746 NA NA NA hsa-miR-320a FSTL1 0.801356001806321 4.91397101474502e-09 0.473337980252804 0.0145905313351278 miRanda -0.171736905095105 0.00489987326953439 NA NA NA hsa-miR-320b FSTL1 1.23473838180754 3.04337566045537e-14 0.473337980252804 0.0145905313351278 miRanda -0.150832042625689 0.00296042817390146 NA NA NA hsa-miR-3607-3p FSTL1 1.01377165357363 9.13355519701165e-05 0.473337980252804 0.0145905313351278 mirMAP -0.193424429977765 1.49322615600234e-09 NA NA NA hsa-miR-362-5p FSTL1 0.41089772861323 0.0404254902071382 0.473337980252804 0.0145905313351278 mirMAP -0.222107361987576 1.03223732708069e-07 NA NA NA hsa-miR-429 FSTL1 0.559451508722375 0.00563641638673083 0.473337980252804 0.0145905313351278 MirTarget;PITA;miRanda -0.384720684495001 8.92986695221669e-22 NA NA NA hsa-miR-576-5p FSTL1 0.940432050128373 6.90227595663302e-12 0.473337980252804 0.0145905313351278 mirMAP -0.207875843946216 0.000591168069330706 NA NA NA hsa-miR-590-3p FSTL1 0.221436901462551 0.0965904764063157 0.473337980252804 0.0145905313351278 miRanda;mirMAP -0.298927910666666 2.3136902985216e-06 NA NA NA hsa-miR-7-1-3p FSTL1 1.13646121619622 1.49823237535933e-14 0.473337980252804 0.0145905313351278 MirTarget -0.377019484088094 6.04966386548936e-12 NA NA NA hsa-miR-9-5p FSTL1 1.65694862043766 2.08325802567323e-05 0.473337980252804 0.0145905313351278 MirTarget -0.10622173299318 6.44401925493822e-07 NA NA NA hsa-miR-944 FSTL1 1.47323925060177 2.61626403984929e-13 0.473337980252804 0.0145905313351278 mirMAP -0.145619224819159 0.000368957469507539 NA NA NA hsa-miR-375 FSTL3 -4.24070205340868 7.48368361454041e-28 1.98651639042846 1.35155158873643e-14 miRNAWalker2_validate -0.19397677764396 2.07620138306218e-12 NA NA NA hsa-miR-9-5p FSTL3 1.65694862043766 2.08325802567323e-05 1.98651639042846 1.35155158873643e-14 miRNAWalker2_validate -0.224183688194479 4.9995499895935e-15 NA NA NA hsa-miR-324-5p FZD8 1.66709479707179 1.45961450445769e-23 -0.204293317181818 0.303884935891493 miRanda -0.162530099857064 0.00104845391384164 NA NA NA hsa-miR-148a-3p GADD45A -0.428944290834563 0.00954246923521465 -0.148778543104967 0.244563831657349 MirTarget;miRNATAP -0.115529771802971 0.000569454583886927 NA NA NA hsa-miR-148b-3p GADD45A 0.386859166050437 4.6728211830726e-06 -0.148778543104967 0.244563831657349 MirTarget -0.297536185776573 6.20121677211309e-06 NA NA NA hsa-miR-152-3p GADD45A -0.382486223604156 0.00710736505198702 -0.148778543104967 0.244563831657349 MirTarget -0.124908349912319 0.00141434525214503 NA NA NA hsa-miR-1976 GADD45B 0.638808083289405 2.94840228896364e-07 -1.29500058031274 1.88372965534317e-17 miRNATAP -0.163735681565526 0.00273735021269302 NA NA NA hsa-miR-324-3p GADD45B 0.867391246413545 3.63808540490361e-10 -1.29500058031274 1.88372965534317e-17 MirTarget;miRNATAP -0.456604551243598 2.13998090154516e-22 NA NA NA hsa-miR-590-3p GADD45B 0.221436901462551 0.0965904764063157 -1.29500058031274 1.88372965534317e-17 miRanda -0.163308519334935 0.00155213230880389 NA NA NA hsa-miR-183-5p GAS1 1.4313129319945 6.25230916431996e-14 0.502668260026961 0.0148596880427093 miRNAWalker2_validate -0.224699627662771 8.73235160942837e-07 NA NA NA hsa-miR-186-5p GAS1 0.353452958261612 0.000145058448579496 0.502668260026961 0.0148596880427093 mirMAP -0.303950138465194 0.00178818310492781 NA NA NA hsa-miR-26b-3p GAS1 0.421575313079363 0.00223298166810883 0.502668260026961 0.0148596880427093 MirTarget -0.232520147336763 0.000361376141096678 NA NA NA hsa-miR-33a-5p GAS1 1.12988965056352 3.35742517382153e-07 0.502668260026961 0.0148596880427093 miRNATAP -0.251455936307766 2.11495145928395e-10 NA NA NA hsa-miR-33b-5p GAS1 0.681845193600723 0.00407790722487864 0.502668260026961 0.0148596880427093 miRNATAP -0.175140518341545 6.17152774476876e-06 NA NA NA hsa-miR-34a-5p GAS1 -0.117372471043915 0.364001947180738 0.502668260026961 0.0148596880427093 miRNAWalker2_validate;miRNATAP -0.21629390329265 0.00199552212750865 24220341 MiR 34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway; Both miR-34a and GAS1 are frequently down-regulated in various tumors; However it has been reported that while GAS1 is down-regulated in papillary thyroid carcinoma PTC miR-34a is up-regulated in this specific type of cancer although their potential roles in PTC tumorigenesis have not been examined to date; A computational search revealed that miR-34a putatively binds to the 3'-UTR of GAS1 gene; In the present study we confirmed previous findings that miR-34a is up-regulated and GAS1 down-regulated in PTC tissues; Further studies indicated that GAS1 is directly targeted by miR-34a; Silencing of GAS1 had similar growth-promoting effects as overexpression of miR-34a; Taken together our results demonstrate that miR-34a regulates GAS1 expression to promote proliferation and suppress apoptosis in PTC cells via PI3K/Akt/Bad pathway tumorigenesis thyroid cancer hsa-miR-34c-5p GAS1 0.565896455062849 0.0224052732281715 0.502668260026961 0.0148596880427093 PITA;miRanda;miRNATAP -0.132239181939779 0.000259211494928984 NA NA NA hsa-miR-3607-3p GAS1 1.01377165357363 9.13355519701165e-05 0.502668260026961 0.0148596880427093 MirTarget -0.107128363597038 0.0019095396399374 NA NA NA hsa-miR-582-3p GAS1 -0.248056267546012 0.143798829508405 0.502668260026961 0.0148596880427093 PITA;miRNATAP -0.278021935770062 1.28857939217708e-07 NA NA NA hsa-miR-944 GAS1 1.47323925060177 2.61626403984929e-13 0.502668260026961 0.0148596880427093 PITA;miRNATAP -0.185094319369121 2.02681969022583e-05 NA NA NA hsa-miR-141-3p GEM 0.730011517758706 0.000120338355004032 -0.0832035969340805 0.705183026217295 MirTarget -0.364834909223804 1.00323517785935e-13 NA NA NA hsa-miR-200a-3p GEM 0.607140814457753 0.00289840524858752 -0.0832035969340805 0.705183026217295 MirTarget -0.336571162836721 1.99849864919944e-13 NA NA NA hsa-miR-200b-3p GEM 0.0717138787925347 0.682858087587209 -0.0832035969340805 0.705183026217295 MirTarget -0.362075200330296 1.53558387122562e-11 NA NA NA hsa-miR-200c-3p GEM 0.630251054099546 0.000131975031451555 -0.0832035969340805 0.705183026217295 MirTarget;miRNATAP -0.310165365600441 5.96905460794619e-08 NA NA NA hsa-miR-224-3p GEM 0.502645536188015 0.0081142387260641 -0.0832035969340805 0.705183026217295 MirTarget -0.232883218477441 3.77703976639626e-06 NA NA NA hsa-miR-429 GEM 0.559451508722375 0.00563641638673083 -0.0832035969340805 0.705183026217295 MirTarget;PITA;miRanda;miRNATAP -0.330051814620321 1.00878783605851e-12 NA NA NA hsa-miR-101-3p GJA1 -1.91263766544878 1.50270129259053e-39 1.11294440604245 2.24989295389294e-06 MirTarget;miRNATAP -0.5933748753161 9.9103600403463e-21 NA NA NA hsa-miR-125b-5p GJA1 -0.993460109818276 5.07736727659894e-12 1.11294440604245 2.24989295389294e-06 miRNATAP -0.396059957139716 1.40045764464871e-08 26335100 The carboxy terminal domain of connexin 43 CT Cx43 modulates the expression of p53 by altering miR 125b expression in low grade human breast cancers breast cancer hsa-miR-130b-3p GJA1 1.44628430084411 9.13980959861273e-24 1.11294440604245 2.24989295389294e-06 MirTarget;miRNATAP -0.304575299601058 8.72096955105042e-06 NA NA NA hsa-miR-142-3p GJA1 1.12754191614028 1.68798138028946e-08 1.11294440604245 2.24989295389294e-06 miRanda -0.259774650105578 2.89262575755604e-07 NA NA NA hsa-miR-148a-5p GJA1 -1.00478606532747 1.38045244999229e-07 1.11294440604245 2.24989295389294e-06 MirTarget;miRNATAP -0.353029267539249 2.12549455639598e-11 NA NA NA hsa-miR-186-5p GJA1 0.353452958261612 0.000145058448579496 1.11294440604245 2.24989295389294e-06 MirTarget;miRNATAP -0.456038941905621 4.30179845140424e-05 NA NA NA hsa-miR-19b-3p GJA1 0.538732279378089 0.000622008277870679 1.11294440604245 2.24989295389294e-06 MirTarget;miRNATAP -0.242357286742378 0.000211533312441004 NA NA NA hsa-miR-217 GJA1 -1.35391381055929 2.42394951427902e-09 1.11294440604245 2.24989295389294e-06 miRanda -0.222748018897366 5.62483570701936e-07 NA NA NA hsa-miR-218-5p GJA1 -1.0725338636959 3.61493686604269e-09 1.11294440604245 2.24989295389294e-06 miRTarBase;miRNATAP -0.224030647757454 6.15479208149898e-05 NA NA NA hsa-miR-23b-3p GJA1 -0.497563803223134 3.31483353357535e-05 1.11294440604245 2.24989295389294e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.233696243574536 0.00675355653442126 NA NA NA hsa-miR-30a-3p GJA1 -2.26144364746452 8.12421214153823e-31 1.11294440604245 2.24989295389294e-06 MirTarget -0.368391706311485 3.29380613359508e-14 NA NA NA hsa-miR-30a-5p GJA1 -1.79779915425811 1.93360169837799e-26 1.11294440604245 2.24989295389294e-06 MirTarget;miRNATAP -0.417068078527451 2.53328638997596e-13 NA NA NA hsa-miR-30b-5p GJA1 -0.400238605368173 0.00346540992719245 1.11294440604245 2.24989295389294e-06 MirTarget;mirMAP -0.58620081677837 1.8238864569972e-15 NA NA NA hsa-miR-30c-5p GJA1 0.021222006155897 0.886366656528128 1.11294440604245 2.24989295389294e-06 MirTarget;mirMAP;miRNATAP -0.368565709273649 1.04829581807427e-07 NA NA NA hsa-miR-30d-3p GJA1 -0.577371911152798 2.02950840095287e-06 1.11294440604245 2.24989295389294e-06 MirTarget -0.725373024529081 1.14672066862523e-18 NA NA NA hsa-miR-30d-5p GJA1 -0.38399848121878 0.000171129616944749 1.11294440604245 2.24989295389294e-06 MirTarget;mirMAP;miRNATAP -0.769647330033854 8.56682903233367e-15 NA NA NA hsa-miR-30e-3p GJA1 -0.890635378639789 1.65740480611339e-16 1.11294440604245 2.24989295389294e-06 MirTarget -0.947679889124155 2.00655635705696e-26 NA NA NA hsa-miR-30e-5p GJA1 -1.02114836019762 6.81961221797866e-17 1.11294440604245 2.24989295389294e-06 MirTarget -0.726247303883667 6.87069380843324e-20 NA NA NA hsa-miR-33a-3p GJA1 0.20371038027126 0.212335697664505 1.11294440604245 2.24989295389294e-06 MirTarget;miRNATAP -0.271563596571947 2.30297098108651e-05 NA NA NA hsa-miR-342-3p GJA1 0.99756868977753 9.28499866272332e-10 1.11294440604245 2.24989295389294e-06 miRNAWalker2_validate;miRNATAP -0.214525204756379 0.000594064236248534 NA NA NA hsa-miR-429 GJA1 0.559451508722375 0.00563641638673083 1.11294440604245 2.24989295389294e-06 miRanda;miRNATAP -0.266523659129153 1.39830528411053e-07 NA NA NA hsa-miR-454-3p GJA1 1.54137391927201 4.15861570449376e-20 1.11294440604245 2.24989295389294e-06 MirTarget;miRNATAP -0.176618319228634 0.00294719720801062 NA NA NA hsa-miR-582-3p GJA1 -0.248056267546012 0.143798829508405 1.11294440604245 2.24989295389294e-06 MirTarget;PITA;miRNATAP -0.649789167238922 2.49080223157664e-29 NA NA NA hsa-miR-582-5p GJA1 -0.0366995972742474 0.821827119138923 1.11294440604245 2.24989295389294e-06 miRNATAP -0.593153910551816 3.10903812076708e-22 NA NA NA hsa-miR-590-3p GJA1 0.221436901462551 0.0965904764063157 1.11294440604245 2.24989295389294e-06 PITA;miRanda -0.450990366764698 4.7496164735858e-09 NA NA NA hsa-miR-664a-3p GJA1 -0.256108763664991 0.0513188660751664 1.11294440604245 2.24989295389294e-06 MirTarget -0.280691421491067 0.000373355331082301 NA NA NA hsa-miR-7-1-3p GJA1 1.13646121619622 1.49823237535933e-14 1.11294440604245 2.24989295389294e-06 mirMAP -0.5077755539439 2.82334812547161e-14 NA NA NA hsa-let-7d-3p GLIPR1 0.770676758773193 9.57945374997326e-13 0.888531209012557 6.06944326174294e-07 MirTarget -0.311447564419881 1.1926184604614e-05 NA NA NA hsa-miR-149-5p GLIPR1 0.443278770827687 0.0642022866136881 0.888531209012557 6.06944326174294e-07 MirTarget -0.298716107052826 2.13337344948036e-21 NA NA NA hsa-miR-16-2-3p GLIPR1 1.1567130855258 1.01867256952189e-14 0.888531209012557 6.06944326174294e-07 mirMAP -0.203911656341893 6.3310656238449e-05 NA NA NA hsa-miR-19b-3p GLIPR1 0.538732279378089 0.000622008277870679 0.888531209012557 6.06944326174294e-07 mirMAP -0.189265255847204 0.000132781705889777 NA NA NA hsa-miR-20a-3p GLIPR1 1.34885093664027 2.07697464119202e-12 0.888531209012557 6.06944326174294e-07 mirMAP -0.121356998294359 0.00238665839279624 NA NA NA hsa-miR-23b-3p GLIPR1 -0.497563803223134 3.31483353357535e-05 0.888531209012557 6.06944326174294e-07 mirMAP -0.525895592379744 1.18606700573841e-16 NA NA NA hsa-miR-28-5p GLIPR1 -0.026996999089909 0.733047113251652 0.888531209012557 6.06944326174294e-07 miRanda -0.276136662812308 0.00624397511176868 NA NA NA hsa-miR-30a-3p GLIPR1 -2.26144364746452 8.12421214153823e-31 0.888531209012557 6.06944326174294e-07 mirMAP -0.123332082077336 0.00104030648124539 NA NA NA hsa-miR-30a-5p GLIPR1 -1.79779915425811 1.93360169837799e-26 0.888531209012557 6.06944326174294e-07 miRNAWalker2_validate -0.15771885415962 0.000339398109439154 NA NA NA hsa-miR-30d-3p GLIPR1 -0.577371911152798 2.02950840095287e-06 0.888531209012557 6.06944326174294e-07 mirMAP -0.375270683839231 3.56108497413796e-09 NA NA NA hsa-miR-30e-3p GLIPR1 -0.890635378639789 1.65740480611339e-16 0.888531209012557 6.06944326174294e-07 mirMAP -0.375640452647519 8.78823610036733e-08 NA NA NA hsa-miR-320a GLIPR1 0.801356001806321 4.91397101474502e-09 0.888531209012557 6.06944326174294e-07 mirMAP -0.174632540303939 0.00201400823669593 NA NA NA hsa-miR-335-3p GLIPR1 0.336785882180547 0.0542446207938138 0.888531209012557 6.06944326174294e-07 mirMAP -0.253445987935289 1.06756163648979e-08 NA NA NA hsa-miR-361-5p GLIPR1 0.0803683277369505 0.314043140368058 0.888531209012557 6.06944326174294e-07 MirTarget;miRanda;mirMAP -0.685438799410685 2.79901555705514e-12 NA NA NA hsa-miR-374a-5p GLIPR1 -0.621903385111545 6.61791773205282e-12 0.888531209012557 6.06944326174294e-07 mirMAP -0.263958276339733 0.00207758994756686 NA NA NA hsa-miR-374b-5p GLIPR1 -0.288413933608091 0.0041474558664058 0.888531209012557 6.06944326174294e-07 mirMAP -0.344933946299582 9.88280565142941e-06 NA NA NA hsa-miR-9-5p GLIPR1 1.65694862043766 2.08325802567323e-05 0.888531209012557 6.06944326174294e-07 mirMAP -0.181537833402565 3.11902089274062e-21 NA NA NA hsa-miR-942-5p GLIPR1 0.678652135586536 2.58063518495056e-07 0.888531209012557 6.06944326174294e-07 MirTarget -0.200157989748485 0.00069181854694961 NA NA NA hsa-miR-326 GPC1 -0.425943992128769 0.0415010315530797 0.64617689316293 2.59917705167697e-06 mirMAP -0.102120528021327 0.000417837552439609 NA NA NA hsa-miR-361-3p GPC1 0.272298288982435 0.0147874880476998 0.64617689316293 2.59917705167697e-06 mirMAP -0.33986199731935 2.1997261658091e-10 NA NA NA hsa-miR-29a-3p GPX7 -1.26881270980079 2.82496991513463e-22 0.730871277218351 0.000317689032362669 MirTarget;miRNATAP -0.210237043435864 0.00128885104900705 NA NA NA hsa-miR-29b-3p GPX7 -0.110721443686039 0.511264554091106 0.730871277218351 0.000317689032362669 MirTarget;miRNATAP -0.189855973871912 0.000317745124600434 NA NA NA hsa-miR-429 GPX7 0.559451508722375 0.00563641638673083 0.730871277218351 0.000317689032362669 miRNATAP -0.139073559659988 0.00150850678519534 NA NA NA hsa-miR-139-5p GREM1 -1.46099200329485 7.85040381494472e-22 2.65760856358153 6.75495709076993e-21 miRanda -0.245739768487076 0.00246263223160335 NA NA NA hsa-miR-200b-3p GREM1 0.0717138787925347 0.682858087587209 2.65760856358153 6.75495709076993e-21 MirTarget -0.453818772240567 3.50877024649863e-10 NA NA NA hsa-miR-30a-3p GREM1 -2.26144364746452 8.12421214153823e-31 2.65760856358153 6.75495709076993e-21 MirTarget -0.205771328236681 0.000846926265044562 NA NA NA hsa-miR-30d-3p GREM1 -0.577371911152798 2.02950840095287e-06 2.65760856358153 6.75495709076993e-21 MirTarget -0.661935168826184 1.93134306816709e-10 NA NA NA hsa-miR-30e-3p GREM1 -0.890635378639789 1.65740480611339e-16 2.65760856358153 6.75495709076993e-21 MirTarget -0.582394640972382 4.40490837519203e-07 NA NA NA hsa-miR-362-3p GREM1 -0.697212068252854 2.61718493418184e-06 2.65760856358153 6.75495709076993e-21 miRanda -0.349335099871513 4.95723392517326e-05 NA NA NA hsa-miR-374a-5p GREM1 -0.621903385111545 6.61791773205282e-12 2.65760856358153 6.75495709076993e-21 mirMAP -0.378577657503469 0.00714901584415136 NA NA NA hsa-miR-374b-5p GREM1 -0.288413933608091 0.0041474558664058 2.65760856358153 6.75495709076993e-21 mirMAP -0.355274527762543 0.0057782881869752 NA NA NA hsa-miR-429 GREM1 0.559451508722375 0.00563641638673083 2.65760856358153 6.75495709076993e-21 MirTarget;miRanda -0.290866715611972 3.99116910498855e-06 NA NA NA hsa-miR-664a-3p GREM1 -0.256108763664991 0.0513188660751664 2.65760856358153 6.75495709076993e-21 mirMAP -0.292990702855179 0.00283903789007156 NA NA NA hsa-miR-155-5p HTRA1 0.533437622040649 0.00248671179205372 1.39038826622041 4.31761109410639e-12 miRNAWalker2_validate -0.181419286331425 0.000322771453972801 NA NA NA hsa-miR-16-5p HTRA1 0.521122945828175 1.40561786410572e-06 1.39038826622041 4.31761109410639e-12 miRNAWalker2_validate -0.471761050773168 7.28731369851011e-09 NA NA NA hsa-miR-26b-5p HTRA1 -0.254478038884324 0.0285227763044636 1.39038826622041 4.31761109410639e-12 miRNAWalker2_validate -0.210229533244251 0.00656195551471165 NA NA NA hsa-miR-628-5p HTRA1 -0.554239048796013 4.92386883216087e-05 1.39038826622041 4.31761109410639e-12 miRNATAP -0.338409916671557 1.66014732506268e-07 NA NA NA hsa-let-7a-3p ID2 0.0966652362351867 0.423761916840503 -0.66708976692791 0.000132355964462565 miRNATAP -0.219269752172642 0.000562753226413693 NA NA NA hsa-miR-19a-3p ID2 1.35800152353624 2.80940447111944e-12 -0.66708976692791 0.000132355964462565 MirTarget;miRNATAP -0.122329975433934 0.00146897453213979 NA NA NA hsa-miR-200c-3p ID2 0.630251054099546 0.000131975031451555 -0.66708976692791 0.000132355964462565 miRNATAP -0.13103869629721 0.00454971926162713 NA NA NA hsa-miR-27a-3p ID2 0.348456440505425 0.00126682892514312 -0.66708976692791 0.000132355964462565 MirTarget;miRNATAP -0.391039644371745 2.60290498448746e-08 NA NA NA hsa-miR-429 ID2 0.559451508722375 0.00563641638673083 -0.66708976692791 0.000132355964462565 PITA;miRanda;miRNATAP -0.123196121489444 0.00108202211097853 NA NA NA hsa-miR-455-3p ID2 2.68574446868387 4.28975903022818e-42 -0.66708976692791 0.000132355964462565 MirTarget;PITA;miRNATAP -0.162870476234884 4.09374487822784e-06 NA NA NA hsa-miR-140-5p IGFBP2 -0.412389003031485 0.000136051708543369 0.243902731257714 0.428058735927799 miRanda -0.406782504917213 0.00104471685559443 NA NA NA hsa-miR-326 IGFBP2 -0.425943992128769 0.0415010315530797 0.243902731257714 0.428058735927799 miRanda -0.210684217221418 0.00104293255092076 NA NA NA hsa-let-7a-3p IGFBP3 0.0966652362351867 0.423761916840503 1.31162008873232 3.37696142113191e-08 miRNATAP -0.240591190921702 0.00591660569748922 NA NA NA hsa-miR-19b-3p IGFBP3 0.538732279378089 0.000622008277870679 1.31162008873232 3.37696142113191e-08 MirTarget;miRNATAP -0.254437784731586 0.000123320743810695 NA NA NA hsa-miR-34a-5p IGFBP3 -0.117372471043915 0.364001947180738 1.31162008873232 3.37696142113191e-08 miRNATAP -0.358491037451918 9.9388240308686e-06 NA NA NA hsa-miR-7-5p IGFBP4 1.55674721532755 2.41989824363914e-11 -0.145478654133717 0.358049512154362 miRNAWalker2_validate -0.117646332512529 0.000104093468724677 NA NA NA hsa-miR-129-5p IL15 -0.246329588499478 0.436451191224681 0.494783341035657 0.0111096202551855 miRanda -0.148947487125466 3.37892748873978e-08 NA NA NA hsa-miR-130b-3p IL15 1.44628430084411 9.13980959861273e-24 0.494783341035657 0.0111096202551855 MirTarget -0.180052152484255 0.00144876901753826 NA NA NA hsa-miR-152-3p IL15 -0.382486223604156 0.00710736505198702 0.494783341035657 0.0111096202551855 MirTarget -0.29636177778451 6.14815500749635e-07 NA NA NA hsa-miR-421 IL15 0.945488088619653 2.35762398527362e-09 0.494783341035657 0.0111096202551855 miRanda -0.178667688755379 0.000758041874918459 NA NA NA hsa-miR-429 IL15 0.559451508722375 0.00563641638673083 0.494783341035657 0.0111096202551855 miRanda -0.144748886371384 0.000551368345718773 NA NA NA hsa-miR-493-5p IL15 -0.471586962917071 0.0221327433064002 0.494783341035657 0.0111096202551855 MirTarget -0.144066091810056 0.000472389704884858 NA NA NA hsa-miR-944 IL15 1.47323925060177 2.61626403984929e-13 0.494783341035657 0.0111096202551855 miRNATAP -0.211329085597943 2.2937662851254e-07 NA NA NA hsa-miR-361-5p IL6 0.0803683277369505 0.314043140368058 -1.04839267298997 0.0016427378053848 miRanda -0.543676267944881 0.00342457947633898 NA NA NA hsa-miR-429 IL6 0.559451508722375 0.00563641638673083 -1.04839267298997 0.0016427378053848 miRanda -0.394149454338654 2.99901296473304e-08 NA NA NA hsa-miR-10b-5p INHBA -0.582989331935508 4.56688330655626e-06 4.26601463971428 2.67387095552321e-28 miRNAWalker2_validate -0.758398199137622 3.98754030780844e-08 NA NA NA hsa-miR-125b-2-3p INHBA -1.87765459914049 1.24704155651697e-13 4.26601463971428 2.67387095552321e-28 mirMAP -0.584182007604014 1.30007979824352e-18 NA NA NA hsa-miR-126-5p INHBA -0.953529188793816 7.91719143295591e-16 4.26601463971428 2.67387095552321e-28 mirMAP -0.890484934838871 8.1462364047791e-10 NA NA NA hsa-miR-16-2-3p INHBA 1.1567130855258 1.01867256952189e-14 4.26601463971428 2.67387095552321e-28 mirMAP -0.445995523830589 0.000119720472807492 NA NA NA hsa-miR-181c-5p INHBA -0.168991199007857 0.196949106150297 4.26601463971428 2.67387095552321e-28 mirMAP -0.903174651545178 1.78125621631575e-11 NA NA NA hsa-miR-195-3p INHBA -0.624259620429699 0.000164279659144497 4.26601463971428 2.67387095552321e-28 mirMAP -0.453907437115361 2.29715013101367e-05 NA NA NA hsa-miR-200b-3p INHBA 0.0717138787925347 0.682858087587209 4.26601463971428 2.67387095552321e-28 TargetScan -0.813494520911663 1.98397517140855e-16 NA NA NA hsa-miR-23b-3p INHBA -0.497563803223134 3.31483353357535e-05 4.26601463971428 2.67387095552321e-28 mirMAP -1.10948525109404 1.96924758117046e-14 NA NA NA hsa-miR-26a-5p INHBA -1.09269574587169 1.24020612216319e-22 4.26601463971428 2.67387095552321e-28 mirMAP -0.998575547181289 4.09311252233436e-11 NA NA NA hsa-miR-26b-5p INHBA -0.254478038884324 0.0285227763044636 4.26601463971428 2.67387095552321e-28 mirMAP -0.81530594264796 9.34447987236181e-08 NA NA NA hsa-miR-30a-5p INHBA -1.79779915425811 1.93360169837799e-26 4.26601463971428 2.67387095552321e-28 mirMAP -0.689237667848418 2.41228115290519e-12 NA NA NA hsa-miR-30b-5p INHBA -0.400238605368173 0.00346540992719245 4.26601463971428 2.67387095552321e-28 mirMAP -0.979377261314895 1.33304008144885e-14 NA NA NA hsa-miR-30c-5p INHBA 0.021222006155897 0.886366656528128 4.26601463971428 2.67387095552321e-28 mirMAP -0.673754121727537 1.54723170296162e-08 NA NA NA hsa-miR-30d-5p INHBA -0.38399848121878 0.000171129616944749 4.26601463971428 2.67387095552321e-28 mirMAP -1.26746097958946 1.34075931280527e-13 NA NA NA hsa-miR-30e-5p INHBA -1.02114836019762 6.81961221797866e-17 4.26601463971428 2.67387095552321e-28 mirMAP -1.5842100984683 1.51298776437553e-32 NA NA NA hsa-miR-335-3p INHBA 0.336785882180547 0.0542446207938138 4.26601463971428 2.67387095552321e-28 mirMAP -0.379759731428777 0.000186425424797331 NA NA NA hsa-miR-3607-3p INHBA 1.01377165357363 9.13355519701165e-05 4.26601463971428 2.67387095552321e-28 mirMAP -0.282124996341455 3.39299748713702e-05 NA NA NA hsa-miR-374a-5p INHBA -0.621903385111545 6.61791773205282e-12 4.26601463971428 2.67387095552321e-28 mirMAP -1.1077187390163 9.0136397757902e-09 NA NA NA hsa-miR-374b-5p INHBA -0.288413933608091 0.0041474558664058 4.26601463971428 2.67387095552321e-28 mirMAP -0.899423217107099 3.67267670640078e-07 NA NA NA hsa-miR-664a-3p INHBA -0.256108763664991 0.0513188660751664 4.26601463971428 2.67387095552321e-28 mirMAP -0.637939023675665 2.37781981674739e-06 NA NA NA hsa-miR-9-5p INHBA 1.65694862043766 2.08325802567323e-05 4.26601463971428 2.67387095552321e-28 mirMAP -0.385397014588617 1.5898069660387e-18 NA NA NA hsa-miR-103a-3p ITGA2 0.556219385347418 1.55815736455067e-09 0.346311971701161 0.0557914662203759 miRNAWalker2_validate;MirTarget;miRNATAP -0.263221912739454 0.0020146102943405 NA NA NA hsa-miR-130a-3p ITGA2 0.67051191119964 4.89747518735144e-06 0.346311971701161 0.0557914662203759 mirMAP -0.167229255007144 0.00174241573906955 NA NA NA hsa-miR-139-5p ITGA2 -1.46099200329485 7.85040381494472e-22 0.346311971701161 0.0557914662203759 PITA;miRanda -0.179977342422204 0.00029435564534397 NA NA NA hsa-miR-15a-5p ITGA2 0.783550182002274 2.60699595655907e-11 0.346311971701161 0.0557914662203759 MirTarget;miRNATAP -0.295271652959175 7.30567926728194e-06 NA NA NA hsa-miR-186-5p ITGA2 0.353452958261612 0.000145058448579496 0.346311971701161 0.0557914662203759 mirMAP -0.366781194007422 1.56320367087872e-05 NA NA NA hsa-miR-18a-5p ITGA2 1.65455873230328 3.76457892277775e-20 0.346311971701161 0.0557914662203759 MirTarget -0.155120230894284 0.000230282139110839 NA NA NA hsa-miR-199a-5p ITGA2 -0.364835768178638 0.0435119211101981 0.346311971701161 0.0557914662203759 miRanda -0.138525415191616 0.00149655053123041 NA NA NA hsa-miR-199b-5p ITGA2 -1.08432682485992 7.68241801134089e-10 0.346311971701161 0.0557914662203759 miRanda -0.125699731513756 0.00433622030989088 NA NA NA hsa-miR-19a-3p ITGA2 1.35800152353624 2.80940447111944e-12 0.346311971701161 0.0557914662203759 MirTarget -0.224082677864399 1.15550463555285e-08 NA NA NA hsa-miR-19b-3p ITGA2 0.538732279378089 0.000622008277870679 0.346311971701161 0.0557914662203759 MirTarget -0.316307052598501 1.30777814836052e-10 NA NA NA hsa-miR-26b-5p ITGA2 -0.254478038884324 0.0285227763044636 0.346311971701161 0.0557914662203759 mirMAP -0.265344476520545 9.63042196397978e-05 NA NA NA hsa-miR-301a-3p ITGA2 2.14132004241926 4.46255413526808e-25 0.346311971701161 0.0557914662203759 mirMAP -0.12632763206279 0.000487530065268887 NA NA NA hsa-miR-30a-5p ITGA2 -1.79779915425811 1.93360169837799e-26 0.346311971701161 0.0557914662203759 miRNAWalker2_validate;mirMAP -0.126199425147886 0.00447937148121829 NA NA NA hsa-miR-30b-5p ITGA2 -0.400238605368173 0.00346540992719245 0.346311971701161 0.0557914662203759 mirMAP -0.219969877332466 0.000130518036619771 NA NA NA hsa-miR-30c-5p ITGA2 0.021222006155897 0.886366656528128 0.346311971701161 0.0557914662203759 mirMAP -0.332986480926492 2.32422656718908e-10 NA NA NA hsa-miR-324-5p ITGA2 1.66709479707179 1.45961450445769e-23 0.346311971701161 0.0557914662203759 miRanda -0.142938749031708 0.00158671999795899 NA NA NA hsa-miR-374b-5p ITGA2 -0.288413933608091 0.0041474558664058 0.346311971701161 0.0557914662203759 MirTarget -0.297780075060814 0.000155810387599993 NA NA NA hsa-miR-454-3p ITGA2 1.54137391927201 4.15861570449376e-20 0.346311971701161 0.0557914662203759 mirMAP -0.191757239033812 2.10849293345859e-05 NA NA NA hsa-miR-495-3p ITGA2 -1.47803501311999 6.88839745293927e-13 0.346311971701161 0.0557914662203759 mirMAP -0.120499026146334 0.00132477071990231 NA NA NA hsa-miR-532-5p ITGA2 -0.021857649390892 0.830992272120134 0.346311971701161 0.0557914662203759 MirTarget -0.286013181143453 0.000230449758178618 NA NA NA hsa-miR-590-5p ITGA2 0.763025362395968 3.65305892505623e-09 0.346311971701161 0.0557914662203759 miRanda -0.16147059329483 0.00748626516135886 NA NA NA hsa-miR-664a-3p ITGA2 -0.256108763664991 0.0513188660751664 0.346311971701161 0.0557914662203759 MirTarget;mirMAP -0.3135544144911 1.51188551081592e-07 NA NA NA hsa-miR-148a-3p ITGA5 -0.428944290834563 0.00954246923521465 2.26391898266591 1.00857076132898e-26 miRNATAP -0.460739953170076 7.20573535736267e-16 NA NA NA hsa-miR-25-3p ITGA5 0.76549796417801 3.32282098247097e-11 2.26391898266591 1.00857076132898e-26 miRNATAP -0.311424655866672 0.000169315670080004 NA NA NA hsa-miR-26a-5p ITGA5 -1.09269574587169 1.24020612216319e-22 2.26391898266591 1.00857076132898e-26 miRNATAP -0.544702822636276 3.95778079261406e-11 25537511 Furthermore we provide experimental evidence to confirm that ITGA5 is a bona fide target of miR-26a liver cancer hsa-miR-26b-5p ITGA5 -0.254478038884324 0.0285227763044636 2.26391898266591 1.00857076132898e-26 miRNATAP -0.460487885590726 3.06199193929785e-08 NA NA NA hsa-miR-27b-3p ITGA5 -0.732682718863563 2.26896143573324e-09 2.26391898266591 1.00857076132898e-26 miRNATAP -0.702938145205959 1.39500552222077e-20 NA NA NA hsa-miR-3065-3p ITGA5 -0.543069092777161 0.0213164885178151 2.26391898266591 1.00857076132898e-26 miRNATAP -0.197509312452116 1.29049230874317e-06 NA NA NA hsa-miR-30a-5p ITGA5 -1.79779915425811 1.93360169837799e-26 2.26391898266591 1.00857076132898e-26 miRNATAP -0.353113981398324 5.08086526872968e-11 NA NA NA hsa-miR-30c-5p ITGA5 0.021222006155897 0.886366656528128 2.26391898266591 1.00857076132898e-26 miRNATAP -0.360580446789248 2.85115027057481e-08 NA NA NA hsa-miR-30d-5p ITGA5 -0.38399848121878 0.000171129616944749 2.26391898266591 1.00857076132898e-26 miRNATAP -0.786437445032788 1.97955295381766e-17 NA NA NA hsa-miR-32-5p ITGA5 -0.317310201890053 0.0102525324475293 2.26391898266591 1.00857076132898e-26 miRNATAP -0.467609983986132 1.86514636190523e-09 NA NA NA hsa-miR-338-3p ITGA5 -0.948755228846395 8.99167125682392e-08 2.26391898266591 1.00857076132898e-26 miRanda -0.178057647560196 0.000985832440085101 NA NA NA hsa-miR-429 ITGA5 0.559451508722375 0.00563641638673083 2.26391898266591 1.00857076132898e-26 miRNATAP -0.323621086900322 6.17229059702819e-12 NA NA NA hsa-miR-92a-3p ITGA5 0.994679542307232 1.32587679156217e-16 2.26391898266591 1.00857076132898e-26 miRNAWalker2_validate;miRTarBase;miRNATAP -0.240966436799812 0.00219729113638704 23499550 The level of miR-92a expression was significantly inversely correlated with ITGA5 expression in various cancer cells; miR-92a overexpression reduced the luciferase activity of the ITGA5 3'-untranslated region suggesting that ITGA5 mRNA is a direct target of miR-92a ovarian cancer hsa-miR-141-3p ITGAV 0.730011517758706 0.000120338355004032 0.843072722413884 7.35174048685618e-08 MirTarget -0.151504816364048 2.60191957759186e-05 NA NA NA hsa-miR-16-2-3p ITGAV 1.1567130855258 1.01867256952189e-14 0.843072722413884 7.35174048685618e-08 mirMAP -0.152931882097527 0.000678344169413549 NA NA NA hsa-miR-186-5p ITGAV 0.353452958261612 0.000145058448579496 0.843072722413884 7.35174048685618e-08 mirMAP -0.230636718119961 0.00200394016614757 NA NA NA hsa-miR-192-5p ITGAV 0.380924502586635 0.00986961967409205 0.843072722413884 7.35174048685618e-08 miRNAWalker2_validate;MirTarget -0.152317641817068 0.0011270082266526 NA NA NA hsa-miR-200a-3p ITGAV 0.607140814457753 0.00289840524858752 0.843072722413884 7.35174048685618e-08 MirTarget -0.174691571767693 1.79937598096872e-07 NA NA NA hsa-miR-25-3p ITGAV 0.76549796417801 3.32282098247097e-11 0.843072722413884 7.35174048685618e-08 MirTarget;miRNATAP -0.164460172212238 0.00535528447967496 NA NA NA hsa-miR-30e-3p ITGAV -0.890635378639789 1.65740480611339e-16 0.843072722413884 7.35174048685618e-08 mirMAP -0.211364972082851 0.000700463251854875 NA NA NA hsa-miR-32-5p ITGAV -0.317310201890053 0.0102525324475293 0.843072722413884 7.35174048685618e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.24892714346461 8.01816213102812e-06 NA NA NA hsa-miR-374a-5p ITGAV -0.621903385111545 6.61791773205282e-12 0.843072722413884 7.35174048685618e-08 mirMAP -0.259763716770641 0.000574661060601618 NA NA NA hsa-miR-374b-5p ITGAV -0.288413933608091 0.0041474558664058 0.843072722413884 7.35174048685618e-08 mirMAP -0.245676898462992 0.000368592536528629 NA NA NA hsa-miR-429 ITGAV 0.559451508722375 0.00563641638673083 0.843072722413884 7.35174048685618e-08 miRanda -0.159111405061634 2.6267798345519e-06 NA NA NA hsa-miR-576-5p ITGAV 0.940432050128373 6.90227595663302e-12 0.843072722413884 7.35174048685618e-08 PITA;mirMAP -0.142840628980598 0.00390783146519895 NA NA NA hsa-miR-582-3p ITGAV -0.248056267546012 0.143798829508405 0.843072722413884 7.35174048685618e-08 MirTarget -0.142674970515395 0.000453336261663201 NA NA NA hsa-miR-590-3p ITGAV 0.221436901462551 0.0965904764063157 0.843072722413884 7.35174048685618e-08 MirTarget;PITA;miRanda -0.154785375083429 0.00292484991114091 NA NA NA hsa-miR-7-1-3p ITGAV 1.13646121619622 1.49823237535933e-14 0.843072722413884 7.35174048685618e-08 mirMAP -0.189945721818657 2.8749953057338e-05 NA NA NA hsa-miR-92a-3p ITGAV 0.994679542307232 1.32587679156217e-16 0.843072722413884 7.35174048685618e-08 MirTarget;miRNATAP -0.186272222116105 0.000862110121080062 NA NA NA hsa-miR-140-3p ITGB1 -0.967453553824782 7.6999446305445e-23 0.635785538137535 3.67317452336206e-07 PITA -0.195418357895355 0.000288399163621207 NA NA NA hsa-miR-16-2-3p ITGB1 1.1567130855258 1.01867256952189e-14 0.635785538137535 3.67317452336206e-07 mirMAP -0.144153039723106 5.56490175975503e-05 NA NA NA hsa-miR-192-5p ITGB1 0.380924502586635 0.00986961967409205 0.635785538137535 3.67317452336206e-07 miRNAWalker2_validate -0.136984076544862 0.000231042554247732 NA NA NA hsa-miR-25-3p ITGB1 0.76549796417801 3.32282098247097e-11 0.635785538137535 3.67317452336206e-07 miRNAWalker2_validate -0.274217740525674 3.51439241030681e-09 NA NA NA hsa-miR-29b-3p ITGB1 -0.110721443686039 0.511264554091106 0.635785538137535 3.67317452336206e-07 MirTarget;miRNATAP -0.134604906339132 3.59761294597943e-05 NA NA NA hsa-miR-29c-3p ITGB1 -2.08166260448948 8.3238369390898e-24 0.635785538137535 3.67317452336206e-07 MirTarget;miRNATAP -0.184472776604945 1.06513669365178e-13 26766915 MiR 29c inhibits cell growth invasion and migration of pancreatic cancer by targeting ITGB1; Further analysis revealed that ITGB1 is one of the functional target genes of miR-29c and knockdown of ITGB1 inhibited the proliferation migration and invasion of PC cells which was similar to the effects of overexpression of miR-29c pancreatic cancer hsa-miR-429 ITGB1 0.559451508722375 0.00563641638673083 0.635785538137535 3.67317452336206e-07 miRanda -0.171979753608087 1.24153744115791e-10 NA NA NA hsa-miR-590-5p ITGB1 0.763025362395968 3.65305892505623e-09 0.635785538137535 3.67317452336206e-07 miRanda -0.110128606424978 0.0088994754623262 NA NA NA hsa-miR-7-1-3p ITGB1 1.13646121619622 1.49823237535933e-14 0.635785538137535 3.67317452336206e-07 MirTarget;mirMAP -0.130644713719968 0.000312721057462282 NA NA NA hsa-miR-769-5p ITGB1 0.0865819375213306 0.445395188017017 0.635785538137535 3.67317452336206e-07 miRNAWalker2_validate -0.162929805187605 0.000841672355138162 NA NA NA hsa-miR-186-5p ITGB3 0.353452958261612 0.000145058448579496 -0.160351074378419 0.548393025862139 mirMAP -0.409952109573956 0.00110247553027533 NA NA NA hsa-miR-18a-3p ITGB3 1.82583720936229 7.51297960972179e-19 -0.160351074378419 0.548393025862139 miRNATAP -0.259516675356121 3.08448216684668e-06 NA NA NA hsa-miR-221-3p ITGB3 0.410625614724387 0.000741090075261272 -0.160351074378419 0.548393025862139 MirTarget -0.282080665929398 0.00319271262689055 NA NA NA hsa-miR-222-3p ITGB3 1.08197052578759 2.32604040301699e-14 -0.160351074378419 0.548393025862139 MirTarget -0.473449166470346 2.16153769866078e-09 NA NA NA hsa-miR-30b-5p ITGB3 -0.400238605368173 0.00346540992719245 -0.160351074378419 0.548393025862139 mirMAP -0.439196050030113 1.85889909589552e-07 20498642 Enforced constitutive expression of mir-30 in BT-ICs inhibits their self-renewal capacity by reducing Ubc9 and induces apoptosis through silencing ITGB3 breast cancer hsa-miR-30c-5p ITGB3 0.021222006155897 0.886366656528128 -0.160351074378419 0.548393025862139 miRNAWalker2_validate;mirMAP;miRNATAP -0.499943731212163 1.04099519567829e-10 NA NA NA hsa-miR-320a ITGB3 0.801356001806321 4.91397101474502e-09 -0.160351074378419 0.548393025862139 miRanda -0.292607339798222 0.000478682947028315 NA NA NA hsa-miR-320b ITGB3 1.23473838180754 3.04337566045537e-14 -0.160351074378419 0.548393025862139 miRanda -0.186523382896149 0.00759095927031934 NA NA NA hsa-miR-338-3p ITGB3 -0.948755228846395 8.99167125682392e-08 -0.160351074378419 0.548393025862139 miRanda -0.269374488899585 2.96719583268045e-05 27431198 Furthermore we also identified a metastasis related protein integrin β3 ITGB3 as a novel target gene of miR-338 metastasis lung cancer hsa-miR-3607-3p ITGB3 1.01377165357363 9.13355519701165e-05 -0.160351074378419 0.548393025862139 MirTarget;mirMAP;miRNATAP -0.281177274077181 1.52872886261478e-10 NA NA NA hsa-miR-425-5p ITGB3 0.931027421598738 6.46235724408844e-08 -0.160351074378419 0.548393025862139 MirTarget -0.335317307647083 4.0835844633639e-07 NA NA NA hsa-miR-429 ITGB3 0.559451508722375 0.00563641638673083 -0.160351074378419 0.548393025862139 miRanda -0.515402242943674 1.19619261182414e-20 NA NA NA hsa-miR-590-3p ITGB3 0.221436901462551 0.0965904764063157 -0.160351074378419 0.548393025862139 PITA;miRanda -0.348435299961168 6.57594087130611e-05 NA NA NA hsa-miR-590-5p ITGB3 0.763025362395968 3.65305892505623e-09 -0.160351074378419 0.548393025862139 miRanda -0.64659197439604 1.05858058473004e-13 NA NA NA hsa-miR-155-5p ITGB5 0.533437622040649 0.00248671179205372 0.447092111973153 0.000319722883344347 miRNAWalker2_validate -0.220467292668732 2.32926315568984e-13 NA NA NA hsa-miR-374a-3p ITGB5 -0.299190081500425 0.00682975596757891 0.447092111973153 0.000319722883344347 MirTarget -0.16897820610897 0.000607021987860573 NA NA NA hsa-miR-378a-5p ITGB5 -1.31095692407946 2.375328908085e-15 0.447092111973153 0.000319722883344347 MirTarget -0.22348012783256 9.44452507253743e-13 NA NA NA hsa-miR-149-5p JUN 0.443278770827687 0.0642022866136881 -0.406452458333556 0.00529454262070968 miRNAWalker2_validate;miRNATAP -0.13798147635329 1.52011589067818e-07 NA NA NA hsa-miR-16-5p JUN 0.521122945828175 1.40561786410572e-06 -0.406452458333556 0.00529454262070968 miRNAWalker2_validate -0.156896269424296 0.00762361936521659 NA NA NA hsa-miR-200b-3p JUN 0.0717138787925347 0.682858087587209 -0.406452458333556 0.00529454262070968 MirTarget;TargetScan -0.1505246140756 3.14972638592719e-05 NA NA NA hsa-miR-200c-3p JUN 0.630251054099546 0.000131975031451555 -0.406452458333556 0.00529454262070968 MirTarget -0.149132086953986 9.85741819973546e-05 NA NA NA hsa-miR-3917 JUN 0.881206418103063 1.02921825829718e-05 -0.406452458333556 0.00529454262070968 MirTarget -0.138885380502224 2.55553984021909e-05 NA NA NA hsa-miR-429 JUN 0.559451508722375 0.00563641638673083 -0.406452458333556 0.00529454262070968 MirTarget;PITA;miRanda;miRNATAP -0.127337260989549 4.67151021689913e-05 NA NA NA hsa-miR-92a-3p JUN 0.994679542307232 1.32587679156217e-16 -0.406452458333556 0.00529454262070968 miRNATAP -0.22222740352937 1.47904297910557e-05 NA NA NA hsa-miR-93-5p JUN 1.61042951896619 5.1280369606967e-24 -0.406452458333556 0.00529454262070968 miRNAWalker2_validate -0.163687155850785 1.63570130702134e-05 NA NA NA hsa-miR-940 JUN 1.25303020594374 1.3005368359451e-10 -0.406452458333556 0.00529454262070968 MirTarget;PITA;miRNATAP -0.11176871246434 0.000559179228679763 NA NA NA hsa-miR-590-3p LAMA2 0.221436901462551 0.0965904764063157 -0.668763906211971 0.0074979937909837 miRanda -0.486315219619538 2.12271598666422e-09 NA NA NA hsa-miR-217 LAMA3 -1.35391381055929 2.42394951427902e-09 2.29750257159021 3.13418480482589e-17 PITA;miRanda -0.2315655688482 1.17411713415295e-05 NA NA NA hsa-miR-26b-5p LAMA3 -0.254478038884324 0.0285227763044636 2.29750257159021 3.13418480482589e-17 miRNAWalker2_validate -0.406479205328374 0.000119702131075166 NA NA NA hsa-miR-10b-5p LAMC1 -0.582989331935508 4.56688330655626e-06 1.05890878482494 2.257399205376e-15 miRNAWalker2_validate -0.293028300160824 2.14537995945773e-10 NA NA NA hsa-miR-126-5p LAMC1 -0.953529188793816 7.91719143295591e-16 1.05890878482494 2.257399205376e-15 mirMAP -0.146250052814606 0.00304041572203498 NA NA NA hsa-miR-139-5p LAMC1 -1.46099200329485 7.85040381494472e-22 1.05890878482494 2.257399205376e-15 miRanda -0.134197539899556 0.000371884753681707 NA NA NA hsa-miR-140-5p LAMC1 -0.412389003031485 0.000136051708543369 1.05890878482494 2.257399205376e-15 MirTarget;PITA;miRanda;miRNATAP -0.148367508622965 0.00750948779648523 NA NA NA hsa-miR-15a-5p LAMC1 0.783550182002274 2.60699595655907e-11 1.05890878482494 2.257399205376e-15 MirTarget -0.210957811494347 2.43262257168465e-05 NA NA NA hsa-miR-200b-3p LAMC1 0.0717138787925347 0.682858087587209 1.05890878482494 2.257399205376e-15 MirTarget;TargetScan -0.239636688992121 8.06816514307707e-13 NA NA NA hsa-miR-200c-3p LAMC1 0.630251054099546 0.000131975031451555 1.05890878482494 2.257399205376e-15 MirTarget;miRNATAP -0.117449801210543 0.0011392486115475 NA NA NA hsa-miR-29a-3p LAMC1 -1.26881270980079 2.82496991513463e-22 1.05890878482494 2.257399205376e-15 MirTarget;miRNATAP -0.182182481655805 3.23106325370556e-05 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29b-3p LAMC1 -0.110721443686039 0.511264554091106 1.05890878482494 2.257399205376e-15 MirTarget;miRNATAP -0.289523360544155 5.30899601654208e-17 NA NA NA hsa-miR-29c-3p LAMC1 -2.08166260448948 8.3238369390898e-24 1.05890878482494 2.257399205376e-15 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.171537215865158 2.81451371739003e-10 NA NA NA hsa-miR-338-3p LAMC1 -0.948755228846395 8.99167125682392e-08 1.05890878482494 2.257399205376e-15 MirTarget;miRanda -0.213129405573725 8.08868846269364e-11 NA NA NA hsa-miR-33a-3p LAMC1 0.20371038027126 0.212335697664505 1.05890878482494 2.257399205376e-15 mirMAP -0.125694932486404 0.000726962280381846 NA NA NA hsa-miR-362-3p LAMC1 -0.697212068252854 2.61718493418184e-06 1.05890878482494 2.257399205376e-15 miRanda -0.210874854741665 1.20601271487835e-07 NA NA NA hsa-miR-374a-5p LAMC1 -0.621903385111545 6.61791773205282e-12 1.05890878482494 2.257399205376e-15 mirMAP -0.185117068177564 0.00469178058840229 NA NA NA hsa-miR-374b-5p LAMC1 -0.288413933608091 0.0041474558664058 1.05890878482494 2.257399205376e-15 mirMAP -0.175788655418089 0.00332261346105154 NA NA NA hsa-miR-429 LAMC1 0.559451508722375 0.00563641638673083 1.05890878482494 2.257399205376e-15 MirTarget;PITA;miRanda;miRNATAP -0.178841287498999 8.18111533845926e-10 NA NA NA hsa-miR-497-5p LAMC1 -0.966244470847844 5.26505649147857e-12 1.05890878482494 2.257399205376e-15 MirTarget;miRNATAP -0.154410114008189 0.000224045134149072 NA NA NA hsa-miR-590-3p LAMC1 0.221436901462551 0.0965904764063157 1.05890878482494 2.257399205376e-15 PITA;miRanda;mirMAP -0.163782871528416 0.000270224421784628 NA NA NA hsa-miR-7-1-3p LAMC1 1.13646121619622 1.49823237535933e-14 1.05890878482494 2.257399205376e-15 mirMAP -0.147394482197662 0.000183304189980798 NA NA NA hsa-miR-92a-3p LAMC1 0.994679542307232 1.32587679156217e-16 1.05890878482494 2.257399205376e-15 miRNAWalker2_validate -0.12901393383078 0.00783731501892839 NA NA NA hsa-miR-942-5p LAMC1 0.678652135586536 2.58063518495056e-07 1.05890878482494 2.257399205376e-15 MirTarget -0.165843346056552 0.000226606398377497 NA NA NA hsa-miR-125b-5p LAMC2 -0.993460109818276 5.07736727659894e-12 3.46594419371739 1.64686476935167e-33 MirTarget -0.673661055907174 4.33755898576263e-14 NA NA NA hsa-miR-199b-5p LAMC2 -1.08432682485992 7.68241801134089e-10 3.46594419371739 1.64686476935167e-33 miRNAWalker2_validate;miRTarBase -0.25630394416789 0.000592410256289566 NA NA NA hsa-miR-338-3p LAMC2 -0.948755228846395 8.99167125682392e-08 3.46594419371739 1.64686476935167e-33 miRanda -0.211309253532861 0.004599363635615 NA NA NA hsa-miR-375 LAMC2 -4.24070205340868 7.48368361454041e-28 3.46594419371739 1.64686476935167e-33 miRanda -0.234032255031293 2.27735611964486e-13 NA NA NA hsa-miR-660-5p LAMC2 -0.202705992887645 0.101093376073573 3.46594419371739 1.64686476935167e-33 MirTarget -0.677538343077072 2.60620388289144e-10 NA NA NA hsa-miR-149-5p LOX 0.443278770827687 0.0642022866136881 1.35314081026531 4.05468571218723e-08 miRNATAP -0.169187514517628 0.000185444319552878 NA NA NA hsa-miR-186-5p LOX 0.353452958261612 0.000145058448579496 1.35314081026531 4.05468571218723e-08 mirMAP -0.422554240274048 0.000321000907695808 NA NA NA hsa-miR-200b-3p LOX 0.0717138787925347 0.682858087587209 1.35314081026531 4.05468571218723e-08 TargetScan -0.427310360450456 2.36764473089762e-12 NA NA NA hsa-miR-218-5p LOX -1.0725338636959 3.61493686604269e-09 1.35314081026531 4.05468571218723e-08 miRNATAP -0.237144518213704 5.49350537195391e-05 NA NA NA hsa-miR-26b-5p LOX -0.254478038884324 0.0285227763044636 1.35314081026531 4.05468571218723e-08 mirMAP -0.552555031005781 2.78828345223609e-09 NA NA NA hsa-miR-29a-3p LOX -1.26881270980079 2.82496991513463e-22 1.35314081026531 4.05468571218723e-08 miRNATAP -0.272621238020961 0.000650299560970329 25153510 Second the direct interaction between one of the upregulated mRNA target the LOX gene which is an EMT key player and a downregulated miRNA the miR-29a was experimentally validated by a luciferase assay in HEK cell thyroid cancer hsa-miR-29b-3p LOX -0.110721443686039 0.511264554091106 1.35314081026531 4.05468571218723e-08 miRNATAP -0.416556956729204 6.06766654690968e-11 NA NA NA hsa-miR-29c-3p LOX -2.08166260448948 8.3238369390898e-24 1.35314081026531 4.05468571218723e-08 miRNATAP -0.204693061631512 4.26006288592958e-05 NA NA NA hsa-miR-3065-3p LOX -0.543069092777161 0.0213164885178151 1.35314081026531 4.05468571218723e-08 miRNATAP -0.220460187177552 1.4194713649145e-06 NA NA NA hsa-miR-30a-5p LOX -1.79779915425811 1.93360169837799e-26 1.35314081026531 4.05468571218723e-08 miRNATAP -0.284770704313371 2.86608298388046e-06 NA NA NA hsa-miR-30c-5p LOX 0.021222006155897 0.886366656528128 1.35314081026531 4.05468571218723e-08 miRNATAP -0.412532273800726 1.42126005558747e-08 NA NA NA hsa-miR-30d-5p LOX -0.38399848121878 0.000171129616944749 1.35314081026531 4.05468571218723e-08 miRNATAP -0.401643241355926 0.000165051951422213 NA NA NA hsa-miR-335-5p LOX -1.17227779671552 1.49282618530733e-10 1.35314081026531 4.05468571218723e-08 miRNAWalker2_validate -0.305709684071108 1.29247230376847e-07 NA NA NA hsa-miR-374a-5p LOX -0.621903385111545 6.61791773205282e-12 1.35314081026531 4.05468571218723e-08 mirMAP -0.624753818422359 1.18622897824539e-07 NA NA NA hsa-miR-374b-5p LOX -0.288413933608091 0.0041474558664058 1.35314081026531 4.05468571218723e-08 mirMAP -0.579768945676151 7.67380988845221e-08 NA NA NA hsa-miR-429 LOX 0.559451508722375 0.00563641638673083 1.35314081026531 4.05468571218723e-08 miRanda;miRNATAP -0.373391291394512 1.34155976876375e-12 NA NA NA hsa-miR-590-3p LOX 0.221436901462551 0.0965904764063157 1.35314081026531 4.05468571218723e-08 miRanda;mirMAP -0.270282439211764 0.000966271914010135 NA NA NA hsa-miR-664a-3p LOX -0.256108763664991 0.0513188660751664 1.35314081026531 4.05468571218723e-08 mirMAP -0.368507116987516 8.29388602649e-06 NA NA NA hsa-miR-193b-3p LOXL1 1.72788400801602 3.0722151264559e-21 0.695278523072105 0.000350916375441837 miRNAWalker2_validate -0.199626442791726 7.35418875210412e-06 NA NA NA hsa-miR-338-3p LOXL2 -0.948755228846395 8.99167125682392e-08 3.11520878428279 3.71623410797103e-42 miRanda -0.32979386647561 3.5783647607291e-08 NA NA NA hsa-miR-126-5p LRP1 -0.953529188793816 7.91719143295591e-16 0.309397942993062 0.0337964477415312 MirTarget -0.202451524306898 0.000106342757409195 NA NA NA hsa-miR-200b-3p LRP1 0.0717138787925347 0.682858087587209 0.309397942993062 0.0337964477415312 TargetScan -0.214870708431571 1.92964331458011e-09 NA NA NA hsa-miR-205-5p LRP1 1.50759485376634 2.0003886738248e-16 0.309397942993062 0.0337964477415312 miRNAWalker2_validate;miRTarBase;MirTarget -0.182169653711106 4.36670422339043e-08 24525843 miR 205 down regulation promotes proliferation of dermatofibrosarcoma protuberans tumor cells by regulating LRP 1 and ERK phosphorylation; In situ hybridization showed that miR-205 expression was evident in dermal fibroblasts of normal skin although hardly detected in tumor cells of DF or DFSP miR-205 inhibitor increased cell proliferation and the luciferase activity of 3'UTR of low-density lipoprotein receptor-related protein-1 LRP-1 in cultured normal dermal fibroblasts; Taken together LRP-1 overexpression caused by the miR-205 down-regulation may play a role in the abnormal proliferation of DFSP cells via directly regulating ERK phosphorylation sarcoma hsa-miR-324-5p LRP1 1.66709479707179 1.45961450445769e-23 0.309397942993062 0.0337964477415312 miRanda -0.253645446582048 1.27760703796189e-12 NA NA NA hsa-miR-339-5p LRP1 1.07771430326938 2.45772601859307e-09 0.309397942993062 0.0337964477415312 miRanda -0.244077134050434 6.26744411590268e-13 NA NA NA hsa-miR-342-3p LRP1 0.99756868977753 9.28499866272332e-10 0.309397942993062 0.0337964477415312 miRanda -0.223180898694729 3.9697985451402e-09 NA NA NA hsa-miR-429 LRP1 0.559451508722375 0.00563641638673083 0.309397942993062 0.0337964477415312 PITA;miRanda;miRNATAP -0.229211121798019 7.56293161268317e-14 NA NA NA hsa-miR-590-3p LRP1 0.221436901462551 0.0965904764063157 0.309397942993062 0.0337964477415312 PITA;miRanda;miRNATAP -0.324832149926446 4.62434648921561e-12 NA NA NA hsa-miR-590-5p LRP1 0.763025362395968 3.65305892505623e-09 0.309397942993062 0.0337964477415312 miRanda -0.421411371250585 2.79521270310515e-19 NA NA NA hsa-miR-15b-3p LRRC15 1.05020782493504 6.38723677324836e-14 3.09679544950127 1.71489210104007e-16 mirMAP -0.544216877303178 3.46110648600388e-06 NA NA NA hsa-miR-17-3p LRRC15 -0.0127974722290336 0.909559935689875 3.09679544950127 1.71489210104007e-16 mirMAP -0.896584018288134 1.86268397126391e-09 NA NA NA hsa-miR-200a-3p LRRC15 0.607140814457753 0.00289840524858752 3.09679544950127 1.71489210104007e-16 mirMAP -0.680145576676736 2.15780682698406e-17 NA NA NA hsa-miR-30a-5p LRRC15 -1.79779915425811 1.93360169837799e-26 3.09679544950127 1.71489210104007e-16 mirMAP -0.471973524573561 5.57397402362044e-07 NA NA NA hsa-miR-30b-5p LRRC15 -0.400238605368173 0.00346540992719245 3.09679544950127 1.71489210104007e-16 mirMAP -0.972087934870717 6.04058329161375e-16 NA NA NA hsa-miR-30c-5p LRRC15 0.021222006155897 0.886366656528128 3.09679544950127 1.71489210104007e-16 mirMAP -0.572364738396235 4.33634110266087e-07 NA NA NA hsa-miR-30d-5p LRRC15 -0.38399848121878 0.000171129616944749 3.09679544950127 1.71489210104007e-16 mirMAP -0.887948906760463 6.48686252763973e-08 NA NA NA hsa-miR-30e-5p LRRC15 -1.02114836019762 6.81961221797866e-17 3.09679544950127 1.71489210104007e-16 mirMAP -0.980301738164577 9.14341238960283e-14 NA NA NA hsa-miR-374a-5p LRRC15 -0.621903385111545 6.61791773205282e-12 3.09679544950127 1.71489210104007e-16 mirMAP -0.641023020254329 0.000511999598846121 NA NA NA hsa-miR-374b-5p LRRC15 -0.288413933608091 0.0041474558664058 3.09679544950127 1.71489210104007e-16 mirMAP -0.502384700650771 0.00295635067570305 NA NA NA hsa-miR-425-5p LRRC15 0.931027421598738 6.46235724408844e-08 3.09679544950127 1.71489210104007e-16 mirMAP -0.362026319393736 0.00018102182014637 NA NA NA hsa-miR-429 LRRC15 0.559451508722375 0.00563641638673083 3.09679544950127 1.71489210104007e-16 miRNATAP -0.634117591266467 6.36049560133327e-15 NA NA NA hsa-miR-590-3p LRRC15 0.221436901462551 0.0965904764063157 3.09679544950127 1.71489210104007e-16 miRanda;mirMAP -0.605566839671764 1.65429952128013e-06 NA NA NA hsa-miR-16-2-3p LUM 1.1567130855258 1.01867256952189e-14 1.96177808360478 1.38304983183597e-15 mirMAP -0.37171630192043 1.81998472032368e-07 NA NA NA hsa-miR-590-3p LUM 0.221436901462551 0.0965904764063157 1.96177808360478 1.38304983183597e-15 miRanda;mirMAP -0.349298559515387 2.36074830050723e-05 NA NA NA hsa-miR-590-5p LUM 0.763025362395968 3.65305892505623e-09 1.96177808360478 1.38304983183597e-15 MirTarget;PITA;miRanda -0.333374567534532 7.15925295184749e-05 NA NA NA hsa-miR-7-1-3p LUM 1.13646121619622 1.49823237535933e-14 1.96177808360478 1.38304983183597e-15 mirMAP -0.283592040733742 9.18154784685876e-05 NA NA NA hsa-miR-146b-5p MAGEE1 0.917975986853978 3.33749259316025e-09 -0.151567479826757 0.425499173259841 miRanda -0.151943840197335 0.00388324904317051 NA NA NA hsa-miR-21-5p MATN2 1.62465922021121 3.44191300985109e-58 -0.302730624610753 0.186477563777129 miRNATAP -0.290254038814619 0.00103112589224694 NA NA NA hsa-miR-126-5p MATN3 -0.953529188793816 7.91719143295591e-16 2.09341761474467 1.11937533762442e-14 mirMAP;miRNATAP -0.50511962499878 3.60214283140012e-07 NA NA NA hsa-miR-148a-3p MATN3 -0.428944290834563 0.00954246923521465 2.09341761474467 1.11937533762442e-14 MirTarget -0.379486909800054 1.73480534585025e-07 NA NA NA hsa-miR-19b-3p MATN3 0.538732279378089 0.000622008277870679 2.09341761474467 1.11937533762442e-14 MirTarget -0.214293346919959 0.00532610769854929 NA NA NA hsa-miR-26b-5p MATN3 -0.254478038884324 0.0285227763044636 2.09341761474467 1.11937533762442e-14 miRNAWalker2_validate -0.483149146819041 3.62609644535324e-06 NA NA NA hsa-miR-27b-3p MATN3 -0.732682718863563 2.26896143573324e-09 2.09341761474467 1.11937533762442e-14 MirTarget;miRNATAP -0.707868411044359 1.49651936214108e-13 NA NA NA hsa-miR-429 MATN3 0.559451508722375 0.00563641638673083 2.09341761474467 1.11937533762442e-14 miRanda -0.246288263858982 3.63018739188215e-05 NA NA NA hsa-miR-590-3p MATN3 0.221436901462551 0.0965904764063157 2.09341761474467 1.11937533762442e-14 miRanda;mirMAP -0.324037154418434 0.000381723553362569 NA NA NA hsa-let-7b-5p MCM7 -0.2489842756826 0.0211384499461719 1.16494147688151 7.85221503407817e-22 miRNAWalker2_validate -0.156628514656083 0.00226516585236242 NA NA NA hsa-miR-155-5p MEST 0.533437622040649 0.00248671179205372 1.00431907071134 9.93717313322278e-08 miRNAWalker2_validate -0.121591798253608 0.00979049307620065 NA NA NA hsa-miR-29a-3p MEST -1.26881270980079 2.82496991513463e-22 1.00431907071134 9.93717313322278e-08 MirTarget;miRNATAP -0.19514626047662 0.00140440693095484 NA NA NA hsa-miR-29b-3p MEST -0.110721443686039 0.511264554091106 1.00431907071134 9.93717313322278e-08 MirTarget;miRNATAP -0.131191578119163 0.00799269021586482 NA NA NA hsa-miR-15a-5p MFAP5 0.783550182002274 2.60699595655907e-11 -0.0624264135674149 0.867521477468741 MirTarget -0.800861877442423 2.96666868110316e-09 NA NA NA hsa-miR-15b-3p MFAP5 1.05020782493504 6.38723677324836e-14 -0.0624264135674149 0.867521477468741 MirTarget -0.864252405559774 6.95357559849671e-15 NA NA NA hsa-miR-15b-5p MFAP5 0.85315666454713 3.79816274836297e-12 -0.0624264135674149 0.867521477468741 MirTarget -1.1194846306919 7.1598684050538e-19 NA NA NA hsa-miR-16-5p MFAP5 0.521122945828175 1.40561786410572e-06 -0.0624264135674149 0.867521477468741 MirTarget -1.24495054191417 1.49084157070459e-17 NA NA NA hsa-miR-200b-3p MFAP5 0.0717138787925347 0.682858087587209 -0.0624264135674149 0.867521477468741 TargetScan -0.765364502156174 2.256707814482e-17 NA NA NA hsa-miR-200c-3p MFAP5 0.630251054099546 0.000131975031451555 -0.0624264135674149 0.867521477468741 miRNATAP -0.541304528681073 2.69063176126594e-08 NA NA NA hsa-miR-23b-3p MFAP5 -0.497563803223134 3.31483353357535e-05 -0.0624264135674149 0.867521477468741 MirTarget -0.551742213813297 4.48411116710001e-05 NA NA NA hsa-miR-320a MFAP5 0.801356001806321 4.91397101474502e-09 -0.0624264135674149 0.867521477468741 miRanda -0.403850395592948 0.000580798344828158 NA NA NA hsa-miR-320b MFAP5 1.23473838180754 3.04337566045537e-14 -0.0624264135674149 0.867521477468741 miRanda -0.418404439753059 1.7199330433138e-05 NA NA NA hsa-miR-33a-3p MFAP5 0.20371038027126 0.212335697664505 -0.0624264135674149 0.867521477468741 MirTarget -0.603874266217662 1.60750477099141e-09 NA NA NA hsa-miR-374b-5p MFAP5 -0.288413933608091 0.0041474558664058 -0.0624264135674149 0.867521477468741 mirMAP -0.476833576409187 0.0034472473389732 NA NA NA hsa-miR-429 MFAP5 0.559451508722375 0.00563641638673083 -0.0624264135674149 0.867521477468741 miRanda;miRNATAP -0.57529450153602 2.69319582261762e-13 NA NA NA hsa-miR-590-3p MFAP5 0.221436901462551 0.0965904764063157 -0.0624264135674149 0.867521477468741 miRanda;mirMAP -0.655091241118421 7.03271318515786e-08 NA NA NA hsa-miR-944 MGP 1.47323925060177 2.61626403984929e-13 -1.83505198681251 9.58447093158305e-12 MirTarget -0.580497231971218 1.00733010370752e-25 NA NA NA hsa-miR-181c-5p MMP14 -0.168991199007857 0.196949106150297 1.45795306566915 1.48707946768001e-26 miRNATAP -0.159949355854262 0.000868831259459645 NA NA NA hsa-miR-26a-5p MMP14 -1.09269574587169 1.24020612216319e-22 1.45795306566915 1.48707946768001e-26 miRNATAP -0.236124080736174 1.15662248222484e-05 NA NA NA hsa-miR-26b-5p MMP14 -0.254478038884324 0.0285227763044636 1.45795306566915 1.48707946768001e-26 miRNATAP -0.239364241354267 9.12715719989101e-06 NA NA NA hsa-miR-29b-2-5p MMP14 -0.502720326849742 0.000730448246894952 1.45795306566915 1.48707946768001e-26 mirMAP -0.342700884345711 4.81162193087021e-17 NA NA NA hsa-miR-3065-3p MMP14 -0.543069092777161 0.0213164885178151 1.45795306566915 1.48707946768001e-26 miRNATAP -0.147814472179282 1.74116793529251e-08 NA NA NA hsa-miR-335-5p MMP14 -1.17227779671552 1.49282618530733e-10 1.45795306566915 1.48707946768001e-26 miRNAWalker2_validate -0.175934723172346 1.32680868547137e-07 NA NA NA hsa-miR-374a-5p MMP14 -0.621903385111545 6.61791773205282e-12 1.45795306566915 1.48707946768001e-26 MirTarget -0.310645724870057 5.22550362039545e-06 NA NA NA hsa-miR-374b-5p MMP14 -0.288413933608091 0.0041474558664058 1.45795306566915 1.48707946768001e-26 MirTarget -0.171276282992386 0.00636218918067832 NA NA NA hsa-miR-9-5p MMP14 1.65694862043766 2.08325802567323e-05 1.45795306566915 1.48707946768001e-26 mirMAP -0.103969415892995 3.33674932157145e-11 NA NA NA hsa-miR-142-3p MMP2 1.12754191614028 1.68798138028946e-08 1.36155925771196 3.02782475240867e-08 miRanda -0.253864301696531 1.81445341511377e-06 NA NA NA hsa-miR-17-5p MMP2 1.41924888736771 2.75805544953758e-18 1.36155925771196 3.02782475240867e-08 miRNAWalker2_validate;TargetScan -0.377336953587542 3.16215952505868e-09 NA NA NA hsa-miR-29a-3p MMP2 -1.26881270980079 2.82496991513463e-22 1.36155925771196 3.02782475240867e-08 miRNATAP -0.281574187371933 0.000410583748961991 24130168 We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC gastric cancer hsa-miR-29b-3p MMP2 -0.110721443686039 0.511264554091106 1.36155925771196 3.02782475240867e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.422158737863611 2.8605591743262e-11 26155940;20657750;25866219;24130681;24130168;26063204 In this study we found that only miR-29b inhibited tumor cell migration and invasion by reducing MMP-2 activity via phospho-AKT/β-catenin signaling and stimulated a more epithelial-like morphology;Further a novel target with potential implications for invasion and metastasis matrix metallopeptidase-2 MMP-2 was identified and confirmed to be a miR-29b target in prostate cancer cells;miR 29b inhibits the progression of esophageal squamous cell carcinoma by targeting MMP 2; The impact of overexpression of miR-29b on putative target MMP-2 were subsequently confirmed via Western blot; Overexpression of miR-29b significantly decreased p<0.05 the protein level of MMP-2 which has previously been identified as a direct target of miR-29b; Thus our study demonstrated that overexpression of miR-29b inhibits tumor growth in part by targeting MMP-2;Since miR-29b plays a role in regulating the migration of cancer cells we hypothesized that HAG induces miR-29b expression to target matrix metalloproteinase-2 MMP-2 thereby suppressing the migration of colon cancer cells; Our study supports the understanding that targeting MMP-2 by miR-29b is a mechanism by which HAG suppresses the migration of colon cancer cells;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC;Furthermore the dual-luciferase reporter assay demonstrated that miR-29b inhibited the expression of the luciferase gene containing the 3'-UTRs of MMP2 and PTEN mRNA; Western blotting and quantitative RT-PCR indicated that miR-29b down-regulated the expression of MMP2 at the protein and mRNA levels; Taken together our results demonstrate that miR-29b serves as a tumor metastasis suppressor which suppresses NSCLC cell metastasis by directly inhibiting MMP2 expression cell migration;metastasis;progression;;;metastasis glioblastoma;prostate cancer;esophageal cancer;colon cancer;gastric cancer;lung squamous cell cancer hsa-miR-29c-3p MMP2 -2.08166260448948 8.3238369390898e-24 1.36155925771196 3.02782475240867e-08 miRNATAP -0.289945224830819 4.54541951982502e-09 23936390;25863127 Furthermore the dual-luciferase reporter assay demonstrated that miR-29c inhibited the expression of the luciferase gene containing the 3'-UTRs of integrin β1 and MMP2 mRNA; Western blotting indicated that miR-29c downregulated the expression of integrin β1 and MMP2 at the protein level; Gelatin zymography analysis further confirmed that miR-29c decreased MMP2 enzyme activity;miR-29c suppresses cell migration and invasion by targeting the MMP2 3'UTR; miR-29c plays an important role in mediating pancreatic cancer metastasis to the liver by targeting MMP2 ;cell migration;metastasis lung cancer;pancreatic cancer hsa-miR-3065-3p MMP2 -0.543069092777161 0.0213164885178151 1.36155925771196 3.02782475240867e-08 miRNATAP -0.211135130020675 3.70296125768518e-06 NA NA NA hsa-miR-335-5p MMP2 -1.17227779671552 1.49282618530733e-10 1.36155925771196 3.02782475240867e-08 miRNAWalker2_validate -0.213848038431988 0.000234441170883688 NA NA NA hsa-miR-338-3p MMP2 -0.948755228846395 8.99167125682392e-08 1.36155925771196 3.02782475240867e-08 miRNAWalker2_validate -0.192179279964822 0.0014657189646418 NA NA NA hsa-miR-106a-5p MMP3 0.67978010057847 0.00221925869726092 3.97295362929542 2.65867234153759e-18 MirTarget -0.463987512570005 3.79796732162613e-07 NA NA NA hsa-miR-106b-5p MMP3 0.50378717276868 1.45412404526866e-05 3.97295362929542 2.65867234153759e-18 MirTarget -0.636898663188801 0.000300401945383267 NA NA NA hsa-miR-20b-5p MMP3 0.345967670847176 0.232014828043601 3.97295362929542 2.65867234153759e-18 MirTarget -0.527882721217407 2.65446632925546e-14 NA NA NA hsa-miR-101-3p MSX1 -1.91263766544878 1.50270129259053e-39 0.851685263150854 1.32192638699416e-05 miRNATAP -0.257178021187934 2.20887894381655e-06 NA NA NA hsa-miR-590-3p MSX1 0.221436901462551 0.0965904764063157 0.851685263150854 1.32192638699416e-05 miRanda -0.207265809539483 0.00133491022376252 NA NA NA hsa-miR-135b-5p MXRA5 1.5570143078477 4.60753610971455e-13 0.618973801164903 0.0153933438759367 MirTarget -0.288011526458947 8.37848440546302e-09 NA NA NA hsa-miR-30d-5p MXRA5 -0.38399848121878 0.000171129616944749 0.618973801164903 0.0153933438759367 miRNATAP -0.487314891506175 7.65179430328398e-06 NA NA NA hsa-miR-335-3p MXRA5 0.336785882180547 0.0542446207938138 0.618973801164903 0.0153933438759367 MirTarget -0.272981958637406 1.6867158766136e-05 NA NA NA hsa-miR-590-3p MXRA5 0.221436901462551 0.0965904764063157 0.618973801164903 0.0153933438759367 MirTarget;PITA;miRanda -0.446948746908704 7.72131813734704e-08 NA NA NA hsa-miR-330-5p MYL9 0.944693925383906 5.04972895657346e-13 0.00185012253070926 0.993128175883829 MirTarget;miRanda -0.251887807446373 0.000317426677431203 NA NA NA hsa-miR-142-3p MYLK 1.12754191614028 1.68798138028946e-08 -0.0951738097536827 0.667186618144027 PITA;miRanda -0.204048449469054 1.60041771958086e-05 NA NA NA hsa-miR-142-5p MYLK 0.288897753038094 0.0900009317815725 -0.0951738097536827 0.667186618144027 mirMAP -0.159423929716952 0.00485066994796822 NA NA NA hsa-miR-15a-5p MYLK 0.783550182002274 2.60699595655907e-11 -0.0951738097536827 0.667186618144027 MirTarget;miRNATAP -0.672500705015833 9.37339762544697e-18 NA NA NA hsa-miR-15b-5p MYLK 0.85315666454713 3.79816274836297e-12 -0.0951738097536827 0.667186618144027 MirTarget;miRNATAP -0.455156189830062 2.24068148343414e-09 NA NA NA hsa-miR-16-2-3p MYLK 1.1567130855258 1.01867256952189e-14 -0.0951738097536827 0.667186618144027 mirMAP -0.496067484233484 5.08550386672562e-16 NA NA NA hsa-miR-16-5p MYLK 0.521122945828175 1.40561786410572e-06 -0.0951738097536827 0.667186618144027 MirTarget;miRNATAP -0.460502796956183 1.76739924560071e-07 NA NA NA hsa-miR-186-5p MYLK 0.353452958261612 0.000145058448579496 -0.0951738097536827 0.667186618144027 mirMAP -0.412722602355652 6.99679879907397e-05 NA NA NA hsa-miR-200b-3p MYLK 0.0717138787925347 0.682858087587209 -0.0951738097536827 0.667186618144027 TargetScan -0.219136351907094 6.34818673031364e-05 NA NA NA hsa-miR-320a MYLK 0.801356001806321 4.91397101474502e-09 -0.0951738097536827 0.667186618144027 miRanda -0.326005501378119 2.3469182943615e-06 NA NA NA hsa-miR-33a-3p MYLK 0.20371038027126 0.212335697664505 -0.0951738097536827 0.667186618144027 mirMAP -0.166653839901417 0.00546879252992855 NA NA NA hsa-miR-362-5p MYLK 0.41089772861323 0.0404254902071382 -0.0951738097536827 0.667186618144027 TargetScan;miRNATAP -0.286132291781569 1.53009326261918e-09 NA NA NA hsa-miR-429 MYLK 0.559451508722375 0.00563641638673083 -0.0951738097536827 0.667186618144027 PITA;miRanda;miRNATAP -0.198640646546051 2.70789314143035e-05 NA NA NA hsa-miR-501-5p MYLK 1.02806906860218 1.63456814370548e-09 -0.0951738097536827 0.667186618144027 MirTarget;PITA;miRNATAP -0.185744876027086 0.000982142378869767 NA NA NA hsa-miR-576-5p MYLK 0.940432050128373 6.90227595663302e-12 -0.0951738097536827 0.667186618144027 PITA;mirMAP -0.421080427247666 6.13360103275758e-10 NA NA NA hsa-miR-582-5p MYLK -0.0366995972742474 0.821827119138923 -0.0951738097536827 0.667186618144027 PITA;mirMAP -0.372756305057575 1.69537297840141e-10 NA NA NA hsa-miR-589-3p MYLK 1.59559692667315 6.2886410639161e-15 -0.0951738097536827 0.667186618144027 mirMAP -0.215018877901743 5.84425441584643e-06 NA NA NA hsa-miR-590-3p MYLK 0.221436901462551 0.0965904764063157 -0.0951738097536827 0.667186618144027 MirTarget;miRanda;mirMAP -0.230080004564972 0.00150695456381191 NA NA NA hsa-miR-590-5p MYLK 0.763025362395968 3.65305892505623e-09 -0.0951738097536827 0.667186618144027 miRanda -0.37676958025824 2.47306724233317e-07 NA NA NA hsa-miR-101-3p NID2 -1.91263766544878 1.50270129259053e-39 2.26708965985908 3.63635606732703e-22 miRNATAP -0.387151342613191 7.83554135727323e-09 NA NA NA hsa-miR-139-5p NID2 -1.46099200329485 7.85040381494472e-22 2.26708965985908 3.63635606732703e-22 miRanda -0.301649401964247 6.46395346531026e-06 NA NA NA hsa-miR-30a-5p NID2 -1.79779915425811 1.93360169837799e-26 2.26708965985908 3.63635606732703e-22 miRNATAP -0.257307893569909 1.59729036762749e-05 NA NA NA hsa-miR-30c-5p NID2 0.021222006155897 0.886366656528128 2.26708965985908 3.63635606732703e-22 miRNATAP -0.487562984616011 5.22045404578771e-12 NA NA NA hsa-miR-30d-5p NID2 -0.38399848121878 0.000171129616944749 2.26708965985908 3.63635606732703e-22 miRNATAP -0.510804836002607 8.6704579789653e-07 NA NA NA hsa-miR-590-3p NID2 0.221436901462551 0.0965904764063157 2.26708965985908 3.63635606732703e-22 miRanda;mirMAP -0.275685629995418 0.000578430569306957 NA NA NA hsa-miR-590-5p NID2 0.763025362395968 3.65305892505623e-09 2.26708965985908 3.63635606732703e-22 miRanda -0.412720268321227 3.21906895582823e-07 NA NA NA hsa-miR-103a-3p NOTCH2 0.556219385347418 1.55815736455067e-09 -0.469472401709393 0.00039435441283637 MirTarget -0.301212431953875 1.26511842406141e-06 NA NA NA hsa-miR-125a-5p NOTCH2 0.215366061934933 0.119550904549401 -0.469472401709393 0.00039435441283637 miRanda -0.285132063846494 4.73539932480587e-12 NA NA NA hsa-miR-130b-5p NOTCH2 1.77265255049999 1.43627774829684e-29 -0.469472401709393 0.00039435441283637 miRNAWalker2_validate;MirTarget -0.205185439357263 2.5208317236025e-09 NA NA NA hsa-miR-146b-5p NOTCH2 0.917975986853978 3.33749259316025e-09 -0.469472401709393 0.00039435441283637 miRanda -0.129775054046794 0.000414720623213647 NA NA NA hsa-miR-15a-5p NOTCH2 0.783550182002274 2.60699595655907e-11 -0.469472401709393 0.00039435441283637 MirTarget -0.405247880664598 8.04689759322514e-18 NA NA NA hsa-miR-15b-5p NOTCH2 0.85315666454713 3.79816274836297e-12 -0.469472401709393 0.00039435441283637 MirTarget -0.153464561745056 0.000924163042531707 NA NA NA hsa-miR-16-1-3p NOTCH2 0.955017760172879 5.95379292601146e-11 -0.469472401709393 0.00039435441283637 mirMAP -0.184419807347776 2.09580034170251e-06 NA NA NA hsa-miR-16-5p NOTCH2 0.521122945828175 1.40561786410572e-06 -0.469472401709393 0.00039435441283637 miRNAWalker2_validate;MirTarget -0.17881025216366 0.00082069474030198 NA NA NA hsa-miR-17-5p NOTCH2 1.41924888736771 2.75805544953758e-18 -0.469472401709393 0.00039435441283637 miRNAWalker2_validate -0.278746321030766 8.01781291496347e-17 NA NA NA hsa-miR-181a-5p NOTCH2 0.819060835827404 1.38616688310277e-13 -0.469472401709393 0.00039435441283637 miRNAWalker2_validate;MirTarget;mirMAP -0.163972757848112 0.00141073215309914 NA NA NA hsa-miR-181b-5p NOTCH2 0.974255518824355 2.64876280203475e-16 -0.469472401709393 0.00039435441283637 MirTarget;mirMAP -0.193615358443473 4.26080233702436e-05 NA NA NA hsa-miR-181d-5p NOTCH2 0.367649966373544 0.00537300571455306 -0.469472401709393 0.00039435441283637 MirTarget -0.160186476522168 0.000257882919466746 NA NA NA hsa-miR-183-5p NOTCH2 1.4313129319945 6.25230916431996e-14 -0.469472401709393 0.00039435441283637 miRNAWalker2_validate -0.143048079661206 1.14082955060723e-06 NA NA NA hsa-miR-186-5p NOTCH2 0.353452958261612 0.000145058448579496 -0.469472401709393 0.00039435441283637 mirMAP -0.23687015298644 0.000149580148577542 NA NA NA hsa-miR-18a-3p NOTCH2 1.82583720936229 7.51297960972179e-19 -0.469472401709393 0.00039435441283637 MirTarget -0.171171273542193 4.73951850703453e-10 NA NA NA hsa-miR-205-5p NOTCH2 1.50759485376634 2.0003886738248e-16 -0.469472401709393 0.00039435441283637 MirTarget -0.125898835395459 3.73174232380756e-05 NA NA NA hsa-miR-2355-5p NOTCH2 1.47205546931107 8.65192179636668e-19 -0.469472401709393 0.00039435441283637 MirTarget -0.165861510156231 6.82605631059105e-07 NA NA NA hsa-miR-25-3p NOTCH2 0.76549796417801 3.32282098247097e-11 -0.469472401709393 0.00039435441283637 miRNAWalker2_validate -0.34840003309693 6.90398550469363e-13 NA NA NA hsa-miR-29b-3p NOTCH2 -0.110721443686039 0.511264554091106 -0.469472401709393 0.00039435441283637 MirTarget -0.247909560837678 1.9210328696028e-13 NA NA NA hsa-miR-30b-5p NOTCH2 -0.400238605368173 0.00346540992719245 -0.469472401709393 0.00039435441283637 mirMAP -0.367599140115636 2.63258685804678e-19 NA NA NA hsa-miR-30c-5p NOTCH2 0.021222006155897 0.886366656528128 -0.469472401709393 0.00039435441283637 mirMAP -0.301931909459307 2.55672698988288e-15 NA NA NA hsa-miR-342-3p NOTCH2 0.99756868977753 9.28499866272332e-10 -0.469472401709393 0.00039435441283637 miRanda -0.209732603172797 1.27407019701174e-09 NA NA NA hsa-miR-34a-5p NOTCH2 -0.117372471043915 0.364001947180738 -0.469472401709393 0.00039435441283637 miRNAWalker2_validate;miRNATAP -0.254235750626349 1.13288386937681e-08 NA NA NA hsa-miR-374b-5p NOTCH2 -0.288413933608091 0.0041474558664058 -0.469472401709393 0.00039435441283637 mirMAP -0.374456213416362 5.16331374328297e-11 NA NA NA hsa-miR-424-5p NOTCH2 1.48125289532143 9.10372985713165e-19 -0.469472401709393 0.00039435441283637 MirTarget -0.133731655763613 5.93194840034555e-05 NA NA NA hsa-miR-429 NOTCH2 0.559451508722375 0.00563641638673083 -0.469472401709393 0.00039435441283637 miRNATAP -0.145904393941797 2.64845584939644e-07 NA NA NA hsa-miR-455-5p NOTCH2 1.408595672323 5.52039116456697e-22 -0.469472401709393 0.00039435441283637 miRanda -0.183499504154376 1.22005707259716e-06 NA NA NA hsa-miR-590-3p NOTCH2 0.221436901462551 0.0965904764063157 -0.469472401709393 0.00039435441283637 miRanda -0.170013049024703 9.291728513823e-05 NA NA NA hsa-miR-590-5p NOTCH2 0.763025362395968 3.65305892505623e-09 -0.469472401709393 0.00039435441283637 miRanda -0.311338109966098 7.35092771924633e-13 NA NA NA hsa-miR-7-1-3p NOTCH2 1.13646121619622 1.49823237535933e-14 -0.469472401709393 0.00039435441283637 MirTarget;mirMAP -0.136428645555569 0.000351636053480205 NA NA NA hsa-miR-708-3p NOTCH2 1.32647174389322 4.87465491977979e-16 -0.469472401709393 0.00039435441283637 mirMAP -0.174693036861107 3.15075885419113e-07 NA NA NA hsa-miR-92a-3p NOTCH2 0.994679542307232 1.32587679156217e-16 -0.469472401709393 0.00039435441283637 miRNAWalker2_validate -0.322112190215803 2.67458161799423e-12 NA NA NA hsa-miR-148a-5p NT5E -1.00478606532747 1.38045244999229e-07 1.15633838740041 3.09618724999389e-05 miRNATAP -0.282391675649606 6.81830987317998e-06 NA NA NA hsa-miR-28-5p NT5E -0.026996999089909 0.733047113251652 1.15633838740041 3.09618724999389e-05 miRanda -0.475959705397589 0.00239419334605427 NA NA NA hsa-miR-30a-5p NT5E -1.79779915425811 1.93360169837799e-26 1.15633838740041 3.09618724999389e-05 miRNAWalker2_validate;miRNATAP -0.219126179984582 0.00137293682937576 NA NA NA hsa-miR-30c-5p NT5E 0.021222006155897 0.886366656528128 1.15633838740041 3.09618724999389e-05 miRNATAP -0.397575381441159 1.15034233051761e-06 NA NA NA hsa-miR-30d-5p NT5E -0.38399848121878 0.000171129616944749 1.15633838740041 3.09618724999389e-05 miRNATAP -0.750108718648878 1.93651559121104e-10 NA NA NA hsa-miR-335-3p NT5E 0.336785882180547 0.0542446207938138 1.15633838740041 3.09618724999389e-05 mirMAP -0.289095087723989 3.06356178389653e-05 NA NA NA hsa-miR-34a-5p NT5E -0.117372471043915 0.364001947180738 1.15633838740041 3.09618724999389e-05 miRNAWalker2_validate -0.597974294373319 1.42767281355541e-10 NA NA NA hsa-miR-3607-3p NT5E 1.01377165357363 9.13355519701165e-05 1.15633838740041 3.09618724999389e-05 mirMAP -0.184541911290934 7.35782790046514e-05 NA NA NA hsa-miR-374a-5p NT5E -0.621903385111545 6.61791773205282e-12 1.15633838740041 3.09618724999389e-05 mirMAP -0.467112190241918 0.000445228371278964 NA NA NA hsa-miR-374b-5p NT5E -0.288413933608091 0.0041474558664058 1.15633838740041 3.09618724999389e-05 mirMAP -0.438175894044235 0.000315277419392618 NA NA NA hsa-miR-30a-5p NTM -1.79779915425811 1.93360169837799e-26 1.83000529362359 6.50446454494725e-15 miRNATAP -0.205601519014622 0.000499405477393462 NA NA NA hsa-miR-30b-3p NTM -0.338530747940815 0.0223424741180399 1.83000529362359 6.50446454494725e-15 MirTarget -0.314926733986211 8.73127390703984e-06 NA NA NA hsa-miR-30c-5p NTM 0.021222006155897 0.886366656528128 1.83000529362359 6.50446454494725e-15 miRNATAP -0.38761665152608 3.58495790840503e-08 NA NA NA hsa-miR-30d-5p NTM -0.38399848121878 0.000171129616944749 1.83000529362359 6.50446454494725e-15 miRNATAP -0.49444327535201 1.42981436396387e-06 NA NA NA hsa-miR-339-5p NTM 1.07771430326938 2.45772601859307e-09 1.83000529362359 6.50446454494725e-15 miRanda -0.182435563498827 0.00144962528677671 NA NA NA hsa-miR-33a-3p NTM 0.20371038027126 0.212335697664505 1.83000529362359 6.50446454494725e-15 mirMAP -0.281598671842663 1.54639683236918e-05 NA NA NA hsa-miR-374b-5p NTM -0.288413933608091 0.0041474558664058 1.83000529362359 6.50446454494725e-15 miRNATAP -0.357321956682894 0.000673161310850415 NA NA NA hsa-miR-429 NTM 0.559451508722375 0.00563641638673083 1.83000529362359 6.50446454494725e-15 miRanda;miRNATAP -0.244791697210594 2.0538033097208e-06 NA NA NA hsa-miR-942-5p NTM 0.678652135586536 2.58063518495056e-07 1.83000529362359 6.50446454494725e-15 MirTarget -0.533081656640645 7.34972354996903e-12 NA NA NA hsa-miR-29a-3p OXTR -1.26881270980079 2.82496991513463e-22 0.639864515888849 0.00182789821886988 miRNATAP -0.205958569175021 0.00179901270849172 NA NA NA hsa-miR-29c-3p OXTR -2.08166260448948 8.3238369390898e-24 0.639864515888849 0.00182789821886988 miRNATAP -0.116506490925986 0.0048984392137273 NA NA NA hsa-miR-944 OXTR 1.47323925060177 2.61626403984929e-13 0.639864515888849 0.00182789821886988 mirMAP -0.125814934313179 0.00381118039582017 NA NA NA hsa-miR-26b-5p PCOLCE2 -0.254478038884324 0.0285227763044636 -1.80394652388959 2.07788050917639e-06 miRNAWalker2_validate -0.377362198803261 0.00916528459432597 NA NA NA hsa-miR-590-3p PCOLCE2 0.221436901462551 0.0965904764063157 -1.80394652388959 2.07788050917639e-06 MirTarget;miRanda -0.403224863095567 0.00136030769654498 NA NA NA hsa-miR-29a-3p PDGFRB -1.26881270980079 2.82496991513463e-22 1.61349776863339 3.00832890375111e-14 miRNATAP -0.252848924108258 0.0002864380072827 NA NA NA hsa-miR-29b-3p PDGFRB -0.110721443686039 0.511264554091106 1.61349776863339 3.00832890375111e-14 miRNATAP -0.381814573387718 5.66152644629818e-12 NA NA NA hsa-miR-29c-3p PDGFRB -2.08166260448948 8.3238369390898e-24 1.61349776863339 3.00832890375111e-14 miRNATAP -0.230825030507139 1.04275605654934e-07 NA NA NA hsa-miR-338-3p PDGFRB -0.948755228846395 8.99167125682392e-08 1.61349776863339 3.00832890375111e-14 miRanda -0.2824081657779 6.98566776548666e-08 NA NA NA hsa-miR-34a-5p PDGFRB -0.117372471043915 0.364001947180738 1.61349776863339 3.00832890375111e-14 MirTarget -0.416833898128444 1.12557808434585e-08 24837198 MicroRNA 34A inhibits the growth invasion and metastasis of gastric cancer by targeting PDGFR and MET expression; In this study our aim was to identify the miRNAs that target PDGFR-α/β and to study the functions of these miRNAs miR-34a was predicted to target PDGFR and luciferase reporter assays showed that miR-34a could directly target PDGFR; Moreover the cancer-associated cell signalling pathway was studied and we found that miR-34a could inhibit Akt PKB protein kinase B phosphorylation which was restored by the overexpression of both PDGFR and MET; In conclusion miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K phosphoinositide 3-kinase/Akt pathway metastasis gastric cancer hsa-miR-361-3p PDGFRB 0.272298288982435 0.0147874880476998 1.61349776863339 3.00832890375111e-14 MirTarget -0.245649935526185 0.00405851316554908 NA NA NA hsa-miR-664a-3p PDGFRB -0.256108763664991 0.0513188660751664 1.61349776863339 3.00832890375111e-14 MirTarget -0.201316703730783 0.00552266661901063 NA NA NA hsa-miR-9-5p PDGFRB 1.65694862043766 2.08325802567323e-05 1.61349776863339 3.00832890375111e-14 MirTarget;miRNATAP -0.101903933904259 2.25485460574598e-05 NA NA NA hsa-miR-28-5p PDLIM4 -0.026996999089909 0.733047113251652 0.225490995280621 0.22752505471309 miRanda -0.464812316511595 8.09212064040295e-06 NA NA NA hsa-miR-326 PDLIM4 -0.425943992128769 0.0415010315530797 0.225490995280621 0.22752505471309 miRanda -0.189319051665036 1.04219760707136e-06 NA NA NA hsa-miR-106a-5p PFN2 0.67978010057847 0.00221925869726092 0.845395635202429 0.000285264834672102 miRNATAP -0.132863960256925 0.00367617157130281 NA NA NA hsa-miR-140-5p PFN2 -0.412389003031485 0.000136051708543369 0.845395635202429 0.000285264834672102 PITA;miRanda -0.322775742642208 0.000631685485779771 NA NA NA hsa-miR-142-3p PFN2 1.12754191614028 1.68798138028946e-08 0.845395635202429 0.000285264834672102 miRanda -0.253876534716432 3.67983427284622e-07 NA NA NA hsa-miR-150-5p PFN2 -0.243749814009231 0.331546276920338 0.845395635202429 0.000285264834672102 miRNATAP -0.207218898180545 2.68548449310715e-07 NA NA NA hsa-miR-20b-5p PFN2 0.345967670847176 0.232014828043601 0.845395635202429 0.000285264834672102 miRNATAP -0.108240965823216 0.00212187936319383 NA NA NA hsa-miR-26b-5p PFN2 -0.254478038884324 0.0285227763044636 0.845395635202429 0.000285264834672102 miRNAWalker2_validate -0.232984971848938 0.00835177772187684 NA NA NA hsa-miR-30a-5p PFN2 -1.79779915425811 1.93360169837799e-26 0.845395635202429 0.000285264834672102 MirTarget;miRNATAP -0.159577141302235 0.00545583603461197 NA NA NA hsa-miR-30e-5p PFN2 -1.02114836019762 6.81961221797866e-17 0.845395635202429 0.000285264834672102 MirTarget -0.42900709614857 9.77126505118172e-08 NA NA NA hsa-miR-342-3p PFN2 0.99756868977753 9.28499866272332e-10 0.845395635202429 0.000285264834672102 miRanda;miRNATAP -0.207426405685803 0.00075799226077452 NA NA NA hsa-miR-3607-3p PFN2 1.01377165357363 9.13355519701165e-05 0.845395635202429 0.000285264834672102 MirTarget;miRNATAP -0.116304201594379 0.002950707555532 NA NA NA hsa-miR-582-5p PFN2 -0.0366995972742474 0.821827119138923 0.845395635202429 0.000285264834672102 PITA -0.25442178921827 4.74367164548382e-05 NA NA NA hsa-miR-139-5p PLAUR -1.46099200329485 7.85040381494472e-22 1.65157943562497 6.0098182112337e-22 miRanda -0.240573789860158 8.42548818906649e-07 NA NA NA hsa-miR-338-5p PLAUR -1.71946558699173 2.62649071488641e-23 1.65157943562497 6.0098182112337e-22 MirTarget -0.142707972886823 0.000923861456834727 NA NA NA hsa-miR-140-5p PLOD1 -0.412389003031485 0.000136051708543369 1.46128677854567 3.7575821245245e-27 MirTarget;miRNATAP -0.169640357819623 0.0032454460480105 NA NA NA hsa-miR-215-5p PLOD1 -0.757663683237828 5.72998183244808e-05 1.46128677854567 3.7575821245245e-27 miRNAWalker2_validate -0.131468036124354 6.45461862056796e-05 NA NA NA hsa-miR-23b-3p PLOD1 -0.497563803223134 3.31483353357535e-05 1.46128677854567 3.7575821245245e-27 miRNAWalker2_validate -0.356203725235985 2.36594004770118e-12 NA NA NA hsa-miR-23b-5p PLOD1 0.141208007066527 0.420202986869364 1.46128677854567 3.7575821245245e-27 MirTarget -0.154720797429559 2.24725257285545e-05 NA NA NA hsa-miR-335-5p PLOD1 -1.17227779671552 1.49282618530733e-10 1.46128677854567 3.7575821245245e-27 MirTarget -0.169698108302499 2.94484581964999e-07 NA NA NA hsa-miR-34a-5p PLOD1 -0.117372471043915 0.364001947180738 1.46128677854567 3.7575821245245e-27 MirTarget;miRNATAP -0.177324144487707 0.000235991528280329 NA NA NA hsa-miR-126-5p PLOD2 -0.953529188793816 7.91719143295591e-16 1.26840914783801 2.55162218616657e-12 mirMAP -0.264857313632838 6.50129825107032e-05 NA NA NA hsa-miR-182-5p PLOD2 1.15060905311096 6.25565852529946e-10 1.26840914783801 2.55162218616657e-12 miRNATAP -0.184796787138585 1.33350864912352e-05 NA NA NA hsa-miR-26b-5p PLOD2 -0.254478038884324 0.0285227763044636 1.26840914783801 2.55162218616657e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.367000010480259 1.10871486903488e-07 26983694;27310702 Thus our data showed that two genes promoting metastasis LOXL2 and PLOD2 were epigenetically regulated by tumor-suppressive microRNAs miR-26a and miR-26b providing important insights into the molecular mechanisms of RCC metastasis;Tumour suppressive miRNA 26a 5p and miR 26b 5p inhibit cell aggressiveness by regulating PLOD2 in bladder cancer; The gene encoding procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 PLOD2 a collagen crosslinking enzyme was directly regulated by miR-26a-5p and miR-26b-5p; PLOD2 which is associated with the stiffness of the extracellular matrix was directly regulated by miR-26a-5p and miR-26b-5p and may be a good prognostic marker in patients with BC metastasis; kidney renal cell cancer;bladder cancer hsa-miR-96-5p PLOD2 1.42326703011157 4.39736150032373e-14 1.26840914783801 2.55162218616657e-12 MirTarget;TargetScan;miRNATAP -0.167475499180879 5.5902294739554e-05 NA NA NA hsa-miR-107 PMEPA1 -0.0447040564279497 0.671618791096755 2.17244187103358 1.8813059909793e-22 mirMAP -0.441966822074258 4.66802093084471e-06 NA NA NA hsa-miR-10b-5p PMEPA1 -0.582989331935508 4.56688330655626e-06 2.17244187103358 1.8813059909793e-22 mirMAP -0.418178163194072 1.06063853574945e-07 NA NA NA hsa-miR-15b-5p PMEPA1 0.85315666454713 3.79816274836297e-12 2.17244187103358 1.8813059909793e-22 mirMAP -0.34041373661874 2.54169414521846e-05 NA NA NA hsa-miR-16-5p PMEPA1 0.521122945828175 1.40561786410572e-06 2.17244187103358 1.8813059909793e-22 mirMAP -0.432229595496455 3.43824421482223e-06 NA NA NA hsa-miR-195-5p PMEPA1 -1.8367376818177 6.9944883988895e-31 2.17244187103358 1.8813059909793e-22 mirMAP -0.23104525259377 0.000115672059449632 NA NA NA hsa-miR-19b-3p PMEPA1 0.538732279378089 0.000622008277870679 2.17244187103358 1.8813059909793e-22 MirTarget;miRNATAP -0.217680827822133 0.000692606263087718 NA NA NA hsa-miR-32-5p PMEPA1 -0.317310201890053 0.0102525324475293 2.17244187103358 1.8813059909793e-22 miRNATAP -0.571249649007293 1.46056471979878e-12 NA NA NA hsa-miR-335-5p PMEPA1 -1.17227779671552 1.49282618530733e-10 2.17244187103358 1.8813059909793e-22 mirMAP -0.252288249493058 3.11876201659788e-06 NA NA NA hsa-miR-338-3p PMEPA1 -0.948755228846395 8.99167125682392e-08 2.17244187103358 1.8813059909793e-22 miRanda -0.155958667778603 0.00578500834653235 NA NA NA hsa-miR-429 PMEPA1 0.559451508722375 0.00563641638673083 2.17244187103358 1.8813059909793e-22 miRNATAP -0.258046259311032 1.97972406283042e-07 NA NA NA hsa-miR-486-5p PMEPA1 -1.70341092285685 6.64232609099498e-14 2.17244187103358 1.8813059909793e-22 miRanda -0.145568211628011 0.000799744198998178 NA NA NA hsa-miR-497-5p PMEPA1 -0.966244470847844 5.26505649147857e-12 2.17244187103358 1.8813059909793e-22 mirMAP -0.260433710560188 0.000241034264932459 NA NA NA hsa-miR-582-5p PMEPA1 -0.0366995972742474 0.821827119138923 2.17244187103358 1.8813059909793e-22 miRNATAP -0.289435514241271 3.04678617833551e-06 NA NA NA hsa-miR-590-3p PMEPA1 0.221436901462551 0.0965904764063157 2.17244187103358 1.8813059909793e-22 miRanda;mirMAP -0.237741828482451 0.00184746994766904 NA NA NA hsa-miR-7-1-3p PMEPA1 1.13646121619622 1.49823237535933e-14 2.17244187103358 1.8813059909793e-22 mirMAP -0.228680812201907 0.000625487536019047 NA NA NA hsa-miR-9-5p PMEPA1 1.65694862043766 2.08325802567323e-05 2.17244187103358 1.8813059909793e-22 mirMAP -0.184454467295841 2.77571938492415e-13 NA NA NA hsa-miR-92a-3p PMEPA1 0.994679542307232 1.32587679156217e-16 2.17244187103358 1.8813059909793e-22 miRNATAP -0.254090545327028 0.00198062604054554 NA NA NA hsa-miR-26b-5p PMP22 -0.254478038884324 0.0285227763044636 0.0541671990011094 0.74837947503027 miRNAWalker2_validate -0.175955176260865 0.00564168299793635 NA NA NA hsa-miR-29b-3p PMP22 -0.110721443686039 0.511264554091106 0.0541671990011094 0.74837947503027 MirTarget;miRNATAP -0.211515712693897 1.07022549418759e-06 NA NA NA hsa-miR-30b-3p PMP22 -0.338530747940815 0.0223424741180399 0.0541671990011094 0.74837947503027 MirTarget -0.196054301335983 7.64529091628821e-05 NA NA NA hsa-miR-361-5p PMP22 0.0803683277369505 0.314043140368058 0.0541671990011094 0.74837947503027 miRanda -0.281568513175014 0.0026448337794633 NA NA NA hsa-miR-429 PMP22 0.559451508722375 0.00563641638673083 0.0541671990011094 0.74837947503027 PITA;miRanda;miRNATAP -0.360497493456821 1.92989168186496e-25 NA NA NA hsa-miR-505-3p PMP22 0.912823669571645 4.0549774967148e-13 0.0541671990011094 0.74837947503027 MirTarget;miRNATAP -0.213745436691715 0.000182508524766495 NA NA NA hsa-miR-582-5p PMP22 -0.0366995972742474 0.821827119138923 0.0541671990011094 0.74837947503027 PITA;miRNATAP -0.33378413077641 4.11453835504705e-14 NA NA NA hsa-miR-590-3p PMP22 0.221436901462551 0.0965904764063157 0.0541671990011094 0.74837947503027 miRanda -0.208277395520798 0.000160363777069605 NA NA NA hsa-miR-651-5p PMP22 0.504713329111777 0.00155970216047171 0.0541671990011094 0.74837947503027 MirTarget -0.301313265452608 2.69252088773404e-11 NA NA NA hsa-miR-944 PMP22 1.47323925060177 2.61626403984929e-13 0.0541671990011094 0.74837947503027 PITA;mirMAP -0.166725755283308 2.41169663036971e-06 NA NA NA hsa-miR-139-5p POSTN -1.46099200329485 7.85040381494472e-22 3.04070989915751 6.10665668175792e-20 miRanda -0.500820320244115 1.05761937449235e-07 NA NA NA hsa-miR-590-3p POSTN 0.221436901462551 0.0965904764063157 3.04070989915751 6.10665668175792e-20 mirMAP -0.456974302075149 5.26953773161503e-05 NA NA NA hsa-miR-106a-5p PRRX1 0.67978010057847 0.00221925869726092 0.452291765079008 0.043236847450332 MirTarget;miRNATAP -0.149711294703946 0.000606554626558551 NA NA NA hsa-miR-106b-5p PRRX1 0.50378717276868 1.45412404526866e-05 0.452291765079008 0.043236847450332 MirTarget;miRNATAP -0.218202548489224 0.00930115521128369 26617763 Down regualtion of miR 106b induces epithelial mesenchymal transition but suppresses metastatic colonization by targeting Prrx1 in colorectal cancer; We identified Prrx1 was a direct target of miR-106b through using target prediction algorithms and dual-Luciferase reporter assay; Moreover Moreover we also found TGF-β1 could down-regulate miR-106b and simultaneously miR-106b also influences the expression of TGF-β1 establishing a negative feedback loop to regulate the expression of Prrx1 together colorectal cancer hsa-miR-144-3p PRRX1 -1.64994343636831 1.13169944841075e-08 0.452291765079008 0.043236847450332 MirTarget -0.104431746900444 0.00166021444175085 NA NA NA hsa-miR-148b-5p PRRX1 1.1533193737265 7.26420964688337e-13 0.452291765079008 0.043236847450332 MirTarget -0.201549347800817 0.000792486282882148 NA NA NA hsa-miR-16-2-3p PRRX1 1.1567130855258 1.01867256952189e-14 0.452291765079008 0.043236847450332 MirTarget -0.371379216693379 3.47374781536902e-09 NA NA NA hsa-miR-17-5p PRRX1 1.41924888736771 2.75805544953758e-18 0.452291765079008 0.043236847450332 MirTarget;TargetScan;miRNATAP -0.404482038250966 1.11404268946177e-12 NA NA NA hsa-miR-186-5p PRRX1 0.353452958261612 0.000145058448579496 0.452291765079008 0.043236847450332 mirMAP -0.273220024765797 0.00966242519864683 NA NA NA hsa-miR-200b-5p PRRX1 0.02621402664548 0.883725338810228 0.452291765079008 0.043236847450332 mirMAP -0.482046965191891 5.18674183391081e-20 NA NA NA hsa-miR-205-3p PRRX1 1.2960640797621 5.80786479909147e-11 0.452291765079008 0.043236847450332 MirTarget -0.350091791680687 1.36325029587777e-13 NA NA NA hsa-miR-20a-5p PRRX1 1.1531986665452 1.02385132917958e-11 0.452291765079008 0.043236847450332 MirTarget;miRNATAP -0.368914474807778 2.96250699388885e-11 NA NA NA hsa-miR-224-3p PRRX1 0.502645536188015 0.0081142387260641 0.452291765079008 0.043236847450332 mirMAP -0.276822765571896 6.24630416001789e-08 NA NA NA hsa-miR-26b-3p PRRX1 0.421575313079363 0.00223298166810883 0.452291765079008 0.043236847450332 MirTarget -0.230080112180853 0.00113626644406054 NA NA NA hsa-miR-29b-1-5p PRRX1 1.39669186711325 4.36960953138935e-11 0.452291765079008 0.043236847450332 MirTarget -0.194171570554551 1.60335544524467e-05 NA NA NA hsa-miR-338-3p PRRX1 -0.948755228846395 8.99167125682392e-08 0.452291765079008 0.043236847450332 miRanda -0.191371024083579 0.000418043024787874 NA NA NA hsa-miR-550a-3p PRRX1 1.63595944765448 5.87048146042097e-24 0.452291765079008 0.043236847450332 miRNATAP -0.180068028456399 0.00206762391068116 NA NA NA hsa-miR-576-5p PRRX1 0.940432050128373 6.90227595663302e-12 0.452291765079008 0.043236847450332 mirMAP -0.266616735573323 0.000131037669685364 NA NA NA hsa-miR-584-5p PRRX1 0.458655788667031 0.0421764547676754 0.452291765079008 0.043236847450332 MirTarget -0.204910814963743 1.74207185353997e-06 NA NA NA hsa-miR-590-3p PRRX1 0.221436901462551 0.0965904764063157 0.452291765079008 0.043236847450332 miRanda;mirMAP;miRNATAP -0.25923966707587 0.000408899786622264 NA NA NA hsa-miR-7-1-3p PRRX1 1.13646121619622 1.49823237535933e-14 0.452291765079008 0.043236847450332 mirMAP -0.391663988568113 6.98527040570725e-10 NA NA NA hsa-miR-93-5p PRRX1 1.61042951896619 5.1280369606967e-24 0.452291765079008 0.043236847450332 MirTarget;miRNATAP -0.209500431119419 0.000334702503682907 NA NA NA hsa-miR-944 PRRX1 1.47323925060177 2.61626403984929e-13 0.452291765079008 0.043236847450332 MirTarget;PITA;mirMAP -0.260311668444527 2.60094721852361e-08 NA NA NA hsa-miR-96-5p PRRX1 1.42326703011157 4.39736150032373e-14 0.452291765079008 0.043236847450332 MirTarget;TargetScan -0.2841427765266 1.21675096363937e-08 NA NA NA hsa-miR-106a-5p PTHLH 0.67978010057847 0.00221925869726092 3.34179379302477 1.5858479549218e-21 MirTarget;miRNATAP -0.436161343807722 5.8577161671179e-10 NA NA NA hsa-miR-107 PTHLH -0.0447040564279497 0.671618791096755 3.34179379302477 1.5858479549218e-21 miRanda -0.568168940941528 0.000188054802626837 NA NA NA hsa-miR-126-5p PTHLH -0.953529188793816 7.91719143295591e-16 3.34179379302477 1.5858479549218e-21 mirMAP -0.528329405311026 5.46733216188476e-05 NA NA NA hsa-miR-139-5p PTHLH -1.46099200329485 7.85040381494472e-22 3.34179379302477 1.5858479549218e-21 miRanda -0.331913977663822 0.000956739321201727 NA NA NA hsa-miR-15b-5p PTHLH 0.85315666454713 3.79816274836297e-12 3.34179379302477 1.5858479549218e-21 MirTarget -0.516470601188938 4.81583653053824e-05 NA NA NA hsa-miR-16-5p PTHLH 0.521122945828175 1.40561786410572e-06 3.34179379302477 1.5858479549218e-21 MirTarget -0.563230863711007 0.000123839854957811 NA NA NA hsa-miR-195-5p PTHLH -1.8367376818177 6.9944883988895e-31 3.34179379302477 1.5858479549218e-21 MirTarget -0.649809698628111 2.30095624207887e-12 NA NA NA hsa-miR-20b-5p PTHLH 0.345967670847176 0.232014828043601 3.34179379302477 1.5858479549218e-21 MirTarget -0.491467103447703 1.99666390122324e-20 NA NA NA hsa-miR-29a-3p PTHLH -1.26881270980079 2.82496991513463e-22 3.34179379302477 1.5858479549218e-21 MirTarget -0.713705989372305 6.59415773322966e-10 NA NA NA hsa-miR-29b-3p PTHLH -0.110721443686039 0.511264554091106 3.34179379302477 1.5858479549218e-21 MirTarget -0.307500567768844 0.00115812721794287 NA NA NA hsa-miR-29c-3p PTHLH -2.08166260448948 8.3238369390898e-24 3.34179379302477 1.5858479549218e-21 MirTarget -0.727686608635907 3.26397950817058e-25 NA NA NA hsa-miR-497-5p PTHLH -0.966244470847844 5.26505649147857e-12 3.34179379302477 1.5858479549218e-21 MirTarget -0.777015144994163 1.28577914856774e-12 NA NA NA hsa-miR-224-5p PTX3 1.94534596857416 1.88348779207332e-19 -1.58780610621522 7.71211150185603e-06 MirTarget -0.327018463696593 2.30032571872818e-06 NA NA NA hsa-miR-330-5p PTX3 0.944693925383906 5.04972895657346e-13 -1.58780610621522 7.71211150185603e-06 miRanda -0.38001410093227 0.00114956535746528 NA NA NA hsa-miR-590-3p PTX3 0.221436901462551 0.0965904764063157 -1.58780610621522 7.71211150185603e-06 miRanda -0.355334912597496 0.00248967127335622 NA NA NA hsa-miR-590-5p PTX3 0.763025362395968 3.65305892505623e-09 -1.58780610621522 7.71211150185603e-06 miRanda -0.60606429977559 2.99744710710506e-07 NA NA NA hsa-miR-7-1-3p PTX3 1.13646121619622 1.49823237535933e-14 -1.58780610621522 7.71211150185603e-06 mirMAP -0.587204176657395 8.00289205060311e-09 NA NA NA hsa-miR-944 PTX3 1.47323925060177 2.61626403984929e-13 -1.58780610621522 7.71211150185603e-06 PITA;mirMAP -0.445586414595221 2.34784036074042e-09 NA NA NA hsa-miR-150-5p PVR -0.243749814009231 0.331546276920338 0.713064055562593 1.07786930144359e-10 mirMAP -0.12083008132863 3.11530024385953e-10 NA NA NA hsa-miR-181d-5p PVR 0.367649966373544 0.00537300571455306 0.713064055562593 1.07786930144359e-10 MirTarget -0.124387321805273 0.00079197418356405 NA NA NA hsa-miR-218-5p PVR -1.0725338636959 3.61493686604269e-09 0.713064055562593 1.07786930144359e-10 mirMAP -0.119982703322782 5.40924707959848e-06 NA NA NA hsa-miR-27b-5p PVR 0.580870079022649 0.000181529223377382 0.713064055562593 1.07786930144359e-10 mirMAP -0.108864185577755 0.000521986899341959 NA NA NA hsa-miR-30b-3p PVR -0.338530747940815 0.0223424741180399 0.713064055562593 1.07786930144359e-10 MirTarget -0.12981143102756 8.48962555476076e-05 NA NA NA hsa-miR-340-5p PVR -0.608415693437977 4.44345153563513e-05 0.713064055562593 1.07786930144359e-10 mirMAP -0.147758546253432 5.52019957532019e-06 NA NA NA hsa-miR-101-5p QSOX1 -1.429324744941 4.00032662184937e-18 -0.341623851415482 0.00284374443339062 mirMAP -0.163840485552086 1.64656522158384e-08 NA NA NA hsa-miR-106a-5p QSOX1 0.67978010057847 0.00221925869726092 -0.341623851415482 0.00284374443339062 mirMAP -0.172725308376961 2.47419059890618e-15 NA NA NA hsa-miR-106b-5p QSOX1 0.50378717276868 1.45412404526866e-05 -0.341623851415482 0.00284374443339062 mirMAP -0.371468059119629 3.44837841877187e-19 NA NA NA hsa-miR-141-5p QSOX1 0.623874471326586 0.0018690552472983 -0.341623851415482 0.00284374443339062 mirMAP -0.165613447671919 1.08655093618127e-11 NA NA NA hsa-miR-142-5p QSOX1 0.288897753038094 0.0900009317815725 -0.341623851415482 0.00284374443339062 mirMAP -0.149387688411948 2.82150592267378e-07 NA NA NA hsa-miR-17-5p QSOX1 1.41924888736771 2.75805544953758e-18 -0.341623851415482 0.00284374443339062 mirMAP -0.108608470934529 0.000245805893779256 NA NA NA hsa-miR-188-5p QSOX1 0.559328953885106 0.000430338888594543 -0.341623851415482 0.00284374443339062 mirMAP -0.141896149697094 5.80165596962758e-06 NA NA NA hsa-miR-192-5p QSOX1 0.380924502586635 0.00986961967409205 -0.341623851415482 0.00284374443339062 mirMAP -0.210866562439385 2.57977273566492e-10 NA NA NA hsa-miR-1976 QSOX1 0.638808083289405 2.94840228896364e-07 -0.341623851415482 0.00284374443339062 MirTarget -0.132464680325319 0.000869299078902456 NA NA NA hsa-miR-205-3p QSOX1 1.2960640797621 5.80786479909147e-11 -0.341623851415482 0.00284374443339062 mirMAP -0.130899575188558 9.42764917941391e-08 NA NA NA hsa-miR-20a-5p QSOX1 1.1531986665452 1.02385132917958e-11 -0.341623851415482 0.00284374443339062 mirMAP -0.123316505364858 1.80396405436412e-05 NA NA NA hsa-miR-20b-5p QSOX1 0.345967670847176 0.232014828043601 -0.341623851415482 0.00284374443339062 mirMAP -0.145611891256806 2.93807983118349e-18 NA NA NA hsa-miR-23b-3p QSOX1 -0.497563803223134 3.31483353357535e-05 -0.341623851415482 0.00284374443339062 mirMAP -0.13387519067408 0.00128083444726946 NA NA NA hsa-miR-23b-5p QSOX1 0.141208007066527 0.420202986869364 -0.341623851415482 0.00284374443339062 mirMAP -0.117981199795936 5.81731832434073e-05 NA NA NA hsa-miR-26a-2-3p QSOX1 -0.444498687388748 0.00325793861409413 -0.341623851415482 0.00284374443339062 mirMAP -0.149109787471343 5.7924552222448e-06 NA NA NA hsa-miR-27b-5p QSOX1 0.580870079022649 0.000181529223377382 -0.341623851415482 0.00284374443339062 mirMAP -0.189143585692786 2.33080178598463e-09 NA NA NA hsa-miR-28-5p QSOX1 -0.026996999089909 0.733047113251652 -0.341623851415482 0.00284374443339062 miRanda -0.316709925537137 6.91857939482382e-07 NA NA NA hsa-miR-29b-2-5p QSOX1 -0.502720326849742 0.000730448246894952 -0.341623851415482 0.00284374443339062 mirMAP -0.119085304929065 0.000368758193138719 NA NA NA hsa-miR-29b-3p QSOX1 -0.110721443686039 0.511264554091106 -0.341623851415482 0.00284374443339062 mirMAP -0.128927085911274 1.2830589532044e-05 NA NA NA hsa-miR-32-5p QSOX1 -0.317310201890053 0.0102525324475293 -0.341623851415482 0.00284374443339062 mirMAP -0.277944585080681 2.77655057082909e-12 NA NA NA hsa-miR-335-3p QSOX1 0.336785882180547 0.0542446207938138 -0.341623851415482 0.00284374443339062 mirMAP -0.149318350584835 1.31271398096756e-07 NA NA NA hsa-miR-340-5p QSOX1 -0.608415693437977 4.44345153563513e-05 -0.341623851415482 0.00284374443339062 mirMAP -0.107938114794377 0.00120884941242087 NA NA NA hsa-miR-342-3p QSOX1 0.99756868977753 9.28499866272332e-10 -0.341623851415482 0.00284374443339062 mirMAP -0.155450782252112 2.05361542280865e-07 NA NA NA hsa-miR-342-5p QSOX1 0.862385578881784 1.60007936373305e-08 -0.341623851415482 0.00284374443339062 mirMAP -0.171489328872959 8.64137834062636e-08 NA NA NA hsa-miR-345-5p QSOX1 0.882162580294938 2.95895678052434e-07 -0.341623851415482 0.00284374443339062 mirMAP -0.164255001911109 7.20959803343839e-09 NA NA NA hsa-miR-34a-5p QSOX1 -0.117372471043915 0.364001947180738 -0.341623851415482 0.00284374443339062 mirMAP -0.239424616456481 3.95277909229888e-10 NA NA NA hsa-miR-362-5p QSOX1 0.41089772861323 0.0404254902071382 -0.341623851415482 0.00284374443339062 TargetScan;mirMAP -0.105862814141641 1.92797757350654e-05 NA NA NA hsa-miR-374b-3p QSOX1 0.425603499218802 0.00146686864653282 -0.341623851415482 0.00284374443339062 mirMAP -0.126725480232311 0.000714229393518438 NA NA NA hsa-miR-378a-5p QSOX1 -1.31095692407946 2.375328908085e-15 -0.341623851415482 0.00284374443339062 mirMAP -0.15842358427425 5.06861879071771e-08 NA NA NA hsa-miR-378c QSOX1 -1.82618708894602 7.26454201089171e-22 -0.341623851415482 0.00284374443339062 mirMAP -0.110468475155608 1.05418290567327e-05 NA NA NA hsa-miR-423-5p QSOX1 0.60141781325829 1.62940950644999e-07 -0.341623851415482 0.00284374443339062 mirMAP -0.164111869998537 0.000142101409799349 NA NA NA hsa-miR-429 QSOX1 0.559451508722375 0.00563641638673083 -0.341623851415482 0.00284374443339062 miRNATAP -0.10064132940508 4.15257832937345e-05 NA NA NA hsa-miR-582-3p QSOX1 -0.248056267546012 0.143798829508405 -0.341623851415482 0.00284374443339062 mirMAP -0.15664456601044 8.04290028874514e-08 NA NA NA hsa-miR-590-3p QSOX1 0.221436901462551 0.0965904764063157 -0.341623851415482 0.00284374443339062 mirMAP -0.203532371843009 4.63435691183189e-08 NA NA NA hsa-miR-625-5p QSOX1 0.346770617079364 0.02860843739549 -0.341623851415482 0.00284374443339062 mirMAP -0.187810559166749 2.06223903250983e-09 NA NA NA hsa-miR-629-3p QSOX1 1.43262037314105 2.37092217984413e-19 -0.341623851415482 0.00284374443339062 mirMAP -0.142655978763679 2.14820197348445e-06 NA NA NA hsa-miR-92a-3p QSOX1 0.994679542307232 1.32587679156217e-16 -0.341623851415482 0.00284374443339062 mirMAP -0.233134126029846 5.54750136220119e-09 NA NA NA hsa-miR-93-3p QSOX1 1.69225547123293 1.50964095575087e-25 -0.341623851415482 0.00284374443339062 mirMAP -0.161164500454418 2.94614669107037e-08 NA NA NA hsa-miR-93-5p QSOX1 1.61042951896619 5.1280369606967e-24 -0.341623851415482 0.00284374443339062 mirMAP -0.19387104952557 4.78333649153166e-11 NA NA NA hsa-miR-16-2-3p RGS4 1.1567130855258 1.01867256952189e-14 2.24460304943091 1.06271360921305e-16 MirTarget;mirMAP -0.35787096834119 5.76375398585091e-06 NA NA NA hsa-miR-26b-5p RGS4 -0.254478038884324 0.0285227763044636 2.24460304943091 1.06271360921305e-16 MirTarget;miRNATAP -0.386561451867827 0.000230851079049378 NA NA NA hsa-miR-30b-3p RGS4 -0.338530747940815 0.0223424741180399 2.24460304943091 1.06271360921305e-16 MirTarget -0.394871246611145 1.3762629801619e-06 NA NA NA hsa-miR-30d-5p RHOB -0.38399848121878 0.000171129616944749 -0.243977592647896 0.122198968932844 miRNATAP -0.227407494430656 0.000742287961782578 NA NA NA hsa-miR-330-3p RHOB -0.0524949332825773 0.719856123539461 -0.243977592647896 0.122198968932844 MirTarget;miRNATAP -0.143443488266074 0.00235933606552242 NA NA NA hsa-miR-429 RHOB 0.559451508722375 0.00563641638673083 -0.243977592647896 0.122198968932844 miRNATAP -0.18009268244258 8.29173454170816e-08 NA NA NA hsa-miR-629-3p RHOB 1.43262037314105 2.37092217984413e-19 -0.243977592647896 0.122198968932844 mirMAP -0.171882130509116 3.48846911475664e-05 NA NA NA hsa-miR-100-5p SAT1 -1.85857794619369 1.248973638996e-25 0.143821103188575 0.300037092372287 miRNAWalker2_validate -0.1230452214133 0.000136550310775622 NA NA NA hsa-miR-107 SAT1 -0.0447040564279497 0.671618791096755 0.143821103188575 0.300037092372287 miRNAWalker2_validate;miRanda -0.172127104309344 0.00289218294842545 NA NA NA hsa-miR-493-5p SAT1 -0.471586962917071 0.0221327433064002 0.143821103188575 0.300037092372287 MirTarget;miRNATAP -0.158482641488529 4.66906337124e-08 NA NA NA hsa-miR-744-5p SAT1 0.436098372735845 0.000850400989351181 0.143821103188575 0.300037092372287 miRNAWalker2_validate -0.194438271867326 2.3453901243461e-05 NA NA NA hsa-miR-155-5p SCG2 0.533437622040649 0.00248671179205372 0.547136505940647 0.0678591849740243 MirTarget;miRNATAP -0.34047767834695 3.56513042027593e-06 NA NA NA hsa-miR-452-3p SCG2 1.09618110917892 2.21867884261816e-07 0.547136505940647 0.0678591849740243 MirTarget -0.292178252158377 1.40983277063804e-06 NA NA NA hsa-miR-590-3p SCG2 0.221436901462551 0.0965904764063157 0.547136505940647 0.0678591849740243 miRanda -0.339275211795446 0.000553822631070744 NA NA NA hsa-miR-125a-5p SDC1 0.215366061934933 0.119550904549401 0.568413261629464 7.69406583889444e-05 mirMAP -0.124797594850466 0.00632224691759805 NA NA NA hsa-miR-125b-5p SDC1 -0.993460109818276 5.07736727659894e-12 0.568413261629464 7.69406583889444e-05 mirMAP -0.289402722027284 6.82356966448428e-12 NA NA NA hsa-miR-28-5p SDC1 -0.026996999089909 0.733047113251652 0.568413261629464 7.69406583889444e-05 miRanda;miRNATAP -0.399545393230049 6.82335836433506e-07 NA NA NA hsa-miR-491-5p SDC1 -0.541680329196715 0.00135829217561865 0.568413261629464 7.69406583889444e-05 miRanda -0.24877282352276 8.1384959576276e-11 NA NA NA hsa-miR-140-3p SDC4 -0.967453553824782 7.6999446305445e-23 0.182242061353392 0.194510087039327 MirTarget -0.258266535652075 1.53291765320524e-05 NA NA NA hsa-miR-194-5p SDC4 -0.0214221838459805 0.872940154118701 0.182242061353392 0.194510087039327 MirTarget;miRNATAP -0.123399161371979 0.00716954089521605 NA NA NA hsa-miR-148a-3p SERPINE1 -0.428944290834563 0.00954246923521465 2.9800460155055 1.19587534601183e-23 miRNATAP -0.588614974561901 2.12257805079507e-13 NA NA NA hsa-miR-148a-5p SERPINE1 -1.00478606532747 1.38045244999229e-07 2.9800460155055 1.19587534601183e-23 miRNATAP -0.483536967493396 2.33591419513461e-12 NA NA NA hsa-miR-30a-5p SERPINE1 -1.79779915425811 1.93360169837799e-26 2.9800460155055 1.19587534601183e-23 miRNATAP -0.538352757158472 6.00868327349311e-13 NA NA NA hsa-miR-30b-5p SERPINE1 -0.400238605368173 0.00346540992719245 2.9800460155055 1.19587534601183e-23 MirTarget -0.571395507493692 5.43373687267357e-09 25170877 miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regulating the apoptosis of cancer cells gastric cancer hsa-miR-30c-5p SERPINE1 0.021222006155897 0.886366656528128 2.9800460155055 1.19587534601183e-23 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.436659380942926 1.62646729429929e-06 NA NA NA hsa-miR-30d-5p SERPINE1 -0.38399848121878 0.000171129616944749 2.9800460155055 1.19587534601183e-23 miRNATAP -0.990118259600798 2.80475112753928e-14 NA NA NA hsa-miR-34a-5p SERPINE1 -0.117372471043915 0.364001947180738 2.9800460155055 1.19587534601183e-23 miRNATAP -0.695579360286566 1.94417698929934e-11 NA NA NA hsa-miR-378a-5p SERPINE1 -1.31095692407946 2.375328908085e-15 2.9800460155055 1.19587534601183e-23 MirTarget -0.818100657001554 3.87528348811537e-27 NA NA NA hsa-miR-769-5p SERPINE1 0.0865819375213306 0.445395188017017 2.9800460155055 1.19587534601183e-23 MirTarget;miRNATAP -0.464940639629924 0.000108602547545672 NA NA NA hsa-miR-942-5p SERPINE1 0.678652135586536 2.58063518495056e-07 2.9800460155055 1.19587534601183e-23 MirTarget -0.302350801947272 0.00309769215152792 NA NA NA hsa-miR-99a-5p SERPINE1 -2.344442285007 7.11841214134739e-24 2.9800460155055 1.19587534601183e-23 miRNAWalker2_validate -0.641238698328427 6.18498189813307e-35 NA NA NA hsa-miR-16-5p SERPINE2 0.521122945828175 1.40561786410572e-06 1.00977350458267 0.000127051429359519 miRNAWalker2_validate -0.299888755530571 0.00495005233997834 NA NA NA hsa-miR-30e-3p SERPINE2 -0.890635378639789 1.65740480611339e-16 1.00977350458267 0.000127051429359519 miRNAWalker2_validate -0.585089226529958 1.45931623971007e-08 NA NA NA hsa-miR-335-3p SERPINE2 0.336785882180547 0.0542446207938138 1.00977350458267 0.000127051429359519 MirTarget -0.24303193588815 0.000224736273137557 NA NA NA hsa-miR-429 SERPINE2 0.559451508722375 0.00563641638673083 1.00977350458267 0.000127051429359519 miRanda -0.26824836182584 2.16340395258322e-06 NA NA NA hsa-miR-26b-5p SERPINH1 -0.254478038884324 0.0285227763044636 2.14974912631278 1.52784744259179e-36 miRNAWalker2_validate -0.213751662270631 0.00194282162186904 NA NA NA hsa-miR-29a-3p SERPINH1 -1.26881270980079 2.82496991513463e-22 2.14974912631278 1.52784744259179e-36 miRNATAP -0.416420725516243 4.32018101210801e-13 27488440 Regulation of LOXL2 and SERPINH1 by antitumor microRNA 29a in lung cancer with idiopathic pulmonary fibrosis; Downregulation of miR-29a caused overexpression of LOXL2 and SERPINH1 in lung cancer and IPF suggesting that these genes are involved in the pathogenesis of these two diseases.Journal of Human Genetics advance online publication 4 August 2016; doi:10.1038/jhg.2016.99 staging lung cancer hsa-miR-29b-3p SERPINH1 -0.110721443686039 0.511264554091106 2.14974912631278 1.52784744259179e-36 miRNATAP -0.215969808598723 4.6490168483997e-06 NA NA NA hsa-miR-29c-3p SERPINH1 -2.08166260448948 8.3238369390898e-24 2.14974912631278 1.52784744259179e-36 miRNATAP -0.433893776329627 1.05074114639068e-36 NA NA NA hsa-miR-3065-3p SERPINH1 -0.543069092777161 0.0213164885178151 2.14974912631278 1.52784744259179e-36 miRNATAP -0.154051130771037 4.37489052332645e-06 NA NA NA hsa-miR-429 SERPINH1 0.559451508722375 0.00563641638673083 2.14974912631278 1.52784744259179e-36 miRanda -0.197106902803215 4.49354278370156e-07 NA NA NA hsa-miR-1301-3p SFRP1 2.13677668481885 6.11093268540831e-44 -2.95958078384978 4.75499210511498e-13 MirTarget -0.729813905963799 9.24664179237345e-12 NA NA NA hsa-miR-16-1-3p SFRP1 0.955017760172879 5.95379292601146e-11 -2.95958078384978 4.75499210511498e-13 MirTarget -0.500471005544228 4.65146708832975e-05 NA NA NA hsa-miR-182-5p SFRP1 1.15060905311096 6.25565852529946e-10 -2.95958078384978 4.75499210511498e-13 mirMAP -0.626181033583446 4.25771390874997e-11 NA NA NA hsa-miR-19b-1-5p SFRP1 0.757034032029085 2.99828133413343e-07 -2.95958078384978 4.75499210511498e-13 MirTarget -0.580873099961256 1.81367093476391e-06 NA NA NA hsa-miR-205-3p SFRP1 1.2960640797621 5.80786479909147e-11 -2.95958078384978 4.75499210511498e-13 MirTarget -0.35222789578559 9.48662601459576e-05 NA NA NA hsa-miR-34b-3p SFRP1 1.05595687443274 4.36830248743191e-05 -2.95958078384978 4.75499210511498e-13 MirTarget -0.222265866926499 0.0019151659754814 NA NA NA hsa-miR-429 SFRP1 0.559451508722375 0.00563641638673083 -2.95958078384978 4.75499210511498e-13 miRNATAP -0.627384286528489 1.24094859245384e-12 NA NA NA hsa-miR-501-5p SFRP1 1.02806906860218 1.63456814370548e-09 -2.95958078384978 4.75499210511498e-13 mirMAP -0.29651175541051 0.00559613064254346 NA NA NA hsa-miR-576-5p SFRP1 0.940432050128373 6.90227595663302e-12 -2.95958078384978 4.75499210511498e-13 MirTarget;PITA -0.580201757626416 8.30377833191631e-06 NA NA NA hsa-miR-7-1-3p SFRP1 1.13646121619622 1.49823237535933e-14 -2.95958078384978 4.75499210511498e-13 MirTarget;mirMAP -0.541291274877068 6.34287106544378e-06 NA NA NA hsa-miR-940 SFRP1 1.25303020594374 1.3005368359451e-10 -2.95958078384978 4.75499210511498e-13 MirTarget -0.376729213752198 4.89984969206311e-05 NA NA NA hsa-miR-96-5p SFRP1 1.42326703011157 4.39736150032373e-14 -2.95958078384978 4.75499210511498e-13 mirMAP -0.744633004325632 5.40718682100252e-16 NA NA NA hsa-miR-135b-5p SFRP4 1.5570143078477 4.60753610971455e-13 0.787276662506151 0.104664692494185 MirTarget -0.808657146273094 3.34911831846647e-18 NA NA NA hsa-miR-144-5p SFRP4 -1.00191595665045 9.05682140522593e-05 0.787276662506151 0.104664692494185 MirTarget -0.524055767236125 8.47283924136114e-11 NA NA NA hsa-miR-26b-5p SFRP4 -0.254478038884324 0.0285227763044636 0.787276662506151 0.104664692494185 miRNAWalker2_validate -0.842276183200146 3.61994203688476e-06 NA NA NA hsa-miR-3607-3p SFRP4 1.01377165357363 9.13355519701165e-05 0.787276662506151 0.104664692494185 MirTarget -0.401474762653473 6.07127804333035e-07 NA NA NA hsa-miR-375 SFRP4 -4.24070205340868 7.48368361454041e-28 0.787276662506151 0.104664692494185 miRanda -0.211604216073612 3.74742151703862e-05 NA NA NA hsa-miR-429 SFRP4 0.559451508722375 0.00563641638673083 0.787276662506151 0.104664692494185 miRanda -0.745325666864608 3.02039176651739e-13 NA NA NA hsa-miR-944 SFRP4 1.47323925060177 2.61626403984929e-13 0.787276662506151 0.104664692494185 mirMAP -0.398427878373845 9.59570170775211e-05 NA NA NA hsa-miR-16-2-3p SGCB 1.1567130855258 1.01867256952189e-14 -0.137763162760558 0.294651538276697 mirMAP -0.158932506133435 1.86783711702765e-05 NA NA NA hsa-miR-182-5p SGCB 1.15060905311096 6.25565852529946e-10 -0.137763162760558 0.294651538276697 mirMAP -0.11117887290365 0.000226491148151586 NA NA NA hsa-miR-429 SGCB 0.559451508722375 0.00563641638673083 -0.137763162760558 0.294651538276697 miRanda;miRNATAP -0.253780950490282 1.01789121195433e-20 NA NA NA hsa-miR-576-5p SGCB 0.940432050128373 6.90227595663302e-12 -0.137763162760558 0.294651538276697 mirMAP -0.130576085446822 0.00142567463665118 NA NA NA hsa-let-7d-5p SGCD 0.481757661442508 3.66030810124939e-07 -0.888311112593696 0.0109835351975672 miRNATAP -0.735245084624209 4.33670496669049e-06 NA NA NA hsa-miR-103a-3p SGCD 0.556219385347418 1.55815736455067e-09 -0.888311112593696 0.0109835351975672 mirMAP -0.734167531716191 7.51999866757276e-06 NA NA NA hsa-miR-106a-5p SGCD 0.67978010057847 0.00221925869726092 -0.888311112593696 0.0109835351975672 mirMAP -0.545405489852724 2.35456595693577e-16 NA NA NA hsa-miR-106b-5p SGCD 0.50378717276868 1.45412404526866e-05 -0.888311112593696 0.0109835351975672 mirMAP -0.834729347190522 9.72344873347192e-11 NA NA NA hsa-miR-130b-5p SGCD 1.77265255049999 1.43627774829684e-29 -0.888311112593696 0.0109835351975672 mirMAP -0.441136349405428 1.30283837158002e-06 NA NA NA hsa-miR-142-5p SGCD 0.288897753038094 0.0900009317815725 -0.888311112593696 0.0109835351975672 miRNATAP -0.365840782221847 4.14045045617092e-05 NA NA NA hsa-miR-144-5p SGCD -1.00191595665045 9.05682140522593e-05 -0.888311112593696 0.0109835351975672 mirMAP -0.164484361642113 0.00544165831927985 NA NA NA hsa-miR-146a-5p SGCD -0.0201236699646614 0.905882759106561 -0.888311112593696 0.0109835351975672 mirMAP -0.300022270191819 0.000824516955397231 NA NA NA hsa-miR-148b-5p SGCD 1.1533193737265 7.26420964688337e-13 -0.888311112593696 0.0109835351975672 mirMAP -0.600480370542976 8.64686606069839e-11 NA NA NA hsa-miR-15a-5p SGCD 0.783550182002274 2.60699595655907e-11 -0.888311112593696 0.0109835351975672 miRNATAP -0.945084170030855 4.11675850218636e-14 NA NA NA hsa-miR-15b-5p SGCD 0.85315666454713 3.79816274836297e-12 -0.888311112593696 0.0109835351975672 miRNATAP -1.0840599934675 3.47450180168767e-20 NA NA NA hsa-miR-16-2-3p SGCD 1.1567130855258 1.01867256952189e-14 -0.888311112593696 0.0109835351975672 mirMAP -1.0926152246658 2.22316128250473e-31 NA NA NA hsa-miR-16-5p SGCD 0.521122945828175 1.40561786410572e-06 -0.888311112593696 0.0109835351975672 miRNATAP -1.2407594665391 7.27448793191652e-20 NA NA NA hsa-miR-17-5p SGCD 1.41924888736771 2.75805544953758e-18 -0.888311112593696 0.0109835351975672 mirMAP -0.843838970551705 3.33305832933917e-22 NA NA NA hsa-miR-19a-3p SGCD 1.35800152353624 2.80940447111944e-12 -0.888311112593696 0.0109835351975672 mirMAP -0.685172519314033 2.14693470040271e-20 NA NA NA hsa-miR-19b-3p SGCD 0.538732279378089 0.000622008277870679 -0.888311112593696 0.0109835351975672 mirMAP -0.855587652531538 4.47526955684452e-20 NA NA NA hsa-miR-200b-3p SGCD 0.0717138787925347 0.682858087587209 -0.888311112593696 0.0109835351975672 mirMAP -0.90098726806463 1.17896390572936e-27 NA NA NA hsa-miR-200c-3p SGCD 0.630251054099546 0.000131975031451555 -0.888311112593696 0.0109835351975672 mirMAP -0.80171328872585 2.10639463207384e-19 NA NA NA hsa-miR-205-3p SGCD 1.2960640797621 5.80786479909147e-11 -0.888311112593696 0.0109835351975672 mirMAP -0.819931370532493 1.45707537045638e-30 NA NA NA hsa-miR-20a-5p SGCD 1.1531986665452 1.02385132917958e-11 -0.888311112593696 0.0109835351975672 mirMAP -0.813931022197144 8.34353376298192e-22 NA NA NA hsa-miR-20b-5p SGCD 0.345967670847176 0.232014828043601 -0.888311112593696 0.0109835351975672 mirMAP -0.407754823596913 1.97259247168911e-15 NA NA NA hsa-miR-21-3p SGCD 1.25126438776674 2.4124216716282e-17 -0.888311112593696 0.0109835351975672 mirMAP -0.602031330634729 1.12380248926779e-09 NA NA NA hsa-miR-25-3p SGCD 0.76549796417801 3.32282098247097e-11 -0.888311112593696 0.0109835351975672 mirMAP -0.830516137575816 9.62138291802369e-11 NA NA NA hsa-miR-26b-5p SGCD -0.254478038884324 0.0285227763044636 -0.888311112593696 0.0109835351975672 miRNATAP -0.527184192935551 6.07049263464226e-05 NA NA NA hsa-miR-29a-5p SGCD 0.323252792625584 0.0370417231222825 -0.888311112593696 0.0109835351975672 mirMAP -0.342827375332653 0.000489926358590722 NA NA NA hsa-miR-29b-1-5p SGCD 1.39669186711325 4.36960953138935e-11 -0.888311112593696 0.0109835351975672 mirMAP -0.416458280349312 2.42569390931964e-09 NA NA NA hsa-miR-30d-3p SGCD -0.577371911152798 2.02950840095287e-06 -0.888311112593696 0.0109835351975672 mirMAP -0.659795037976127 1.04520320734868e-07 NA NA NA hsa-miR-32-5p SGCD -0.317310201890053 0.0102525324475293 -0.888311112593696 0.0109835351975672 mirMAP -0.548636994413089 8.35306849295919e-06 NA NA NA hsa-miR-331-5p SGCD 0.851618030062133 1.42670149420057e-14 -0.888311112593696 0.0109835351975672 mirMAP -0.686334319895253 2.99159756147783e-07 NA NA NA hsa-miR-335-3p SGCD 0.336785882180547 0.0542446207938138 -0.888311112593696 0.0109835351975672 mirMAP -0.270580398455158 0.00190575317555665 NA NA NA hsa-miR-339-5p SGCD 1.07771430326938 2.45772601859307e-09 -0.888311112593696 0.0109835351975672 PITA;miRNATAP -0.558770231810331 7.71784433888321e-12 NA NA NA hsa-miR-33a-3p SGCD 0.20371038027126 0.212335697664505 -0.888311112593696 0.0109835351975672 mirMAP -0.647079584881645 3.79910603761992e-12 NA NA NA hsa-miR-33a-5p SGCD 1.12988965056352 3.35742517382153e-07 -0.888311112593696 0.0109835351975672 mirMAP;miRNATAP -0.589537795531257 3.23702335153529e-19 NA NA NA hsa-miR-33b-5p SGCD 0.681845193600723 0.00407790722487864 -0.888311112593696 0.0109835351975672 mirMAP;miRNATAP -0.480252989155502 1.00257203806931e-13 NA NA NA hsa-miR-3607-3p SGCD 1.01377165357363 9.13355519701165e-05 -0.888311112593696 0.0109835351975672 mirMAP -0.36009529352128 4.18930266622187e-10 NA NA NA hsa-miR-363-3p SGCD -0.608157508016978 0.0186109501272176 -0.888311112593696 0.0109835351975672 mirMAP -0.371383702995683 1.46581893954096e-10 NA NA NA hsa-miR-3682-3p SGCD 0.707626231028898 1.50609185515014e-05 -0.888311112593696 0.0109835351975672 mirMAP -0.288009869660679 0.0019646006609727 NA NA NA hsa-miR-429 SGCD 0.559451508722375 0.00563641638673083 -0.888311112593696 0.0109835351975672 mirMAP -0.740338597860052 7.2531788404233e-25 NA NA NA hsa-miR-500a-5p SGCD 0.675401699376111 8.24389004707854e-05 -0.888311112593696 0.0109835351975672 mirMAP -0.264199721415174 0.00281463569947172 NA NA NA hsa-miR-576-5p SGCD 0.940432050128373 6.90227595663302e-12 -0.888311112593696 0.0109835351975672 mirMAP -0.769909007022156 6.5001332812178e-13 NA NA NA hsa-miR-582-3p SGCD -0.248056267546012 0.143798829508405 -0.888311112593696 0.0109835351975672 mirMAP -0.552820956905655 4.6205872513298e-10 NA NA NA hsa-miR-589-3p SGCD 1.59559692667315 6.2886410639161e-15 -0.888311112593696 0.0109835351975672 mirMAP -0.542397060399824 2.22674026246082e-13 NA NA NA hsa-miR-590-3p SGCD 0.221436901462551 0.0965904764063157 -0.888311112593696 0.0109835351975672 PITA;miRanda;mirMAP;miRNATAP -0.723719128603136 1.5843506966542e-10 NA NA NA hsa-miR-590-5p SGCD 0.763025362395968 3.65305892505623e-09 -0.888311112593696 0.0109835351975672 miRanda -0.932930792242096 1.92664385721451e-16 NA NA NA hsa-miR-625-3p SGCD 0.0858338965684338 0.484971431380441 -0.888311112593696 0.0109835351975672 mirMAP -0.34585808025692 0.00562761990666662 NA NA NA hsa-miR-7-1-3p SGCD 1.13646121619622 1.49823237535933e-14 -0.888311112593696 0.0109835351975672 mirMAP -0.866115041519209 5.9758754405029e-19 NA NA NA hsa-miR-9-5p SGCD 1.65694862043766 2.08325802567323e-05 -0.888311112593696 0.0109835351975672 mirMAP;miRNATAP -0.248260926223801 7.84773276854208e-11 NA NA NA hsa-miR-92a-3p SGCD 0.994679542307232 1.32587679156217e-16 -0.888311112593696 0.0109835351975672 mirMAP -1.14670682162594 4.65293737432995e-22 NA NA NA hsa-miR-93-5p SGCD 1.61042951896619 5.1280369606967e-24 -0.888311112593696 0.0109835351975672 mirMAP -0.737787781636917 1.07119270646185e-16 NA NA NA hsa-miR-944 SGCD 1.47323925060177 2.61626403984929e-13 -0.888311112593696 0.0109835351975672 PITA;mirMAP;miRNATAP -0.356872764486667 1.14862118726937e-06 NA NA NA hsa-miR-590-3p SGCG 0.221436901462551 0.0965904764063157 -3.10430497154922 1.24329063334252e-10 miRanda -0.592870456602057 0.000230695030235439 NA NA NA hsa-miR-590-5p SGCG 0.763025362395968 3.65305892505623e-09 -3.10430497154922 1.24329063334252e-10 miRanda -0.7219740525275 9.38823677694025e-06 NA NA NA hsa-let-7b-3p SLC6A8 0.120166961637302 0.299224004314356 0.586843466587024 0.000427399215428463 miRNATAP -0.182716308536106 0.00396587333155465 NA NA NA hsa-miR-125a-3p SLC6A8 0.116035800853173 0.444825559956959 0.586843466587024 0.000427399215428463 miRanda -0.148789132897893 0.00199221518814831 NA NA NA hsa-miR-342-3p SLC6A8 0.99756868977753 9.28499866272332e-10 0.586843466587024 0.000427399215428463 miRanda -0.132838911934895 0.00256341518096167 NA NA NA hsa-miR-200b-3p SLIT2 0.0717138787925347 0.682858087587209 -1.48763043664968 6.43609989104193e-06 TargetScan -0.242110972646264 0.00343053535091602 NA NA NA hsa-miR-26b-3p SLIT2 0.421575313079363 0.00223298166810883 -1.48763043664968 6.43609989104193e-06 miRNATAP -0.360059665346084 0.000603375196598489 NA NA NA hsa-miR-576-5p SLIT2 0.940432050128373 6.90227595663302e-12 -1.48763043664968 6.43609989104193e-06 mirMAP -0.858689876470077 1.57267319356269e-17 NA NA NA hsa-miR-590-3p SLIT2 0.221436901462551 0.0965904764063157 -1.48763043664968 6.43609989104193e-06 miRanda -0.452056174147486 3.21117356245666e-05 NA NA NA hsa-miR-135b-5p SLIT3 1.5570143078477 4.60753610971455e-13 -1.15177984522623 1.71248117402065e-05 mirMAP -0.30781786285151 5.27747081233791e-09 NA NA NA hsa-miR-148b-5p SLIT3 1.1533193737265 7.26420964688337e-13 -1.15177984522623 1.71248117402065e-05 mirMAP -0.376884385268848 1.5692516426057e-07 NA NA NA hsa-miR-16-2-3p SLIT3 1.1567130855258 1.01867256952189e-14 -1.15177984522623 1.71248117402065e-05 mirMAP -0.54908453509139 2.72051132214771e-13 NA NA NA hsa-miR-188-5p SLIT3 0.559328953885106 0.000430338888594543 -1.15177984522623 1.71248117402065e-05 mirMAP -0.227409821171186 0.00214941035393929 NA NA NA hsa-miR-1976 SLIT3 0.638808083289405 2.94840228896364e-07 -1.15177984522623 1.71248117402065e-05 mirMAP -0.457580841374413 8.89913711083427e-07 NA NA NA hsa-miR-200c-5p SLIT3 0.904697667677842 1.36157973413856e-06 -1.15177984522623 1.71248117402065e-05 mirMAP -0.401447384196413 5.39686795901502e-11 NA NA NA hsa-miR-224-3p SLIT3 0.502645536188015 0.0081142387260641 -1.15177984522623 1.71248117402065e-05 mirMAP -0.296196660402521 1.68580070784217e-06 NA NA NA hsa-miR-26b-5p SLIT3 -0.254478038884324 0.0285227763044636 -1.15177984522623 1.71248117402065e-05 mirMAP -0.304595182952332 0.0027539006455703 NA NA NA hsa-miR-301a-3p SLIT3 2.14132004241926 4.46255413526808e-25 -1.15177984522623 1.71248117402065e-05 mirMAP -0.333476900655311 3.96828723423853e-10 NA NA NA hsa-miR-330-5p SLIT3 0.944693925383906 5.04972895657346e-13 -1.15177984522623 1.71248117402065e-05 miRanda;mirMAP -0.371084113931239 2.38817561621743e-05 NA NA NA hsa-miR-33a-3p SLIT3 0.20371038027126 0.212335697664505 -1.15177984522623 1.71248117402065e-05 mirMAP -0.230891409602716 0.00160482059395488 NA NA NA hsa-miR-362-5p SLIT3 0.41089772861323 0.0404254902071382 -1.15177984522623 1.71248117402065e-05 TargetScan -0.218070072953319 0.000191583275943144 NA NA NA hsa-miR-429 SLIT3 0.559451508722375 0.00563641638673083 -1.15177984522623 1.71248117402065e-05 miRNATAP -0.347105454548413 1.36302081836843e-09 NA NA NA hsa-miR-454-3p SLIT3 1.54137391927201 4.15861570449376e-20 -1.15177984522623 1.71248117402065e-05 mirMAP -0.43603471120277 5.20951985380624e-11 NA NA NA hsa-miR-500a-5p SLIT3 0.675401699376111 8.24389004707854e-05 -1.15177984522623 1.71248117402065e-05 mirMAP -0.28219202330312 3.27260820337397e-05 NA NA NA hsa-miR-550a-3p SLIT3 1.63595944765448 5.87048146042097e-24 -1.15177984522623 1.71248117402065e-05 mirMAP -0.412005749880742 3.28134100683303e-09 NA NA NA hsa-miR-589-3p SLIT3 1.59559692667315 6.2886410639161e-15 -1.15177984522623 1.71248117402065e-05 mirMAP -0.342242077370966 2.70471972007478e-09 NA NA NA hsa-miR-590-3p SLIT3 0.221436901462551 0.0965904764063157 -1.15177984522623 1.71248117402065e-05 miRanda;mirMAP -0.421946401936753 1.6275677575275e-06 NA NA NA hsa-miR-590-5p SLIT3 0.763025362395968 3.65305892505623e-09 -1.15177984522623 1.71248117402065e-05 miRanda -0.680157032024962 9.2811060787648e-15 NA NA NA hsa-miR-96-5p SLIT3 1.42326703011157 4.39736150032373e-14 -1.15177984522623 1.71248117402065e-05 TargetScan -0.289166845512742 1.69272790131467e-06 NA NA NA hsa-miR-107 SNAI2 -0.0447040564279497 0.671618791096755 1.57363779849313 5.91219248669788e-24 miRanda -0.284005615551857 2.80975142738815e-05 NA NA NA hsa-miR-126-5p SNAI2 -0.953529188793816 7.91719143295591e-16 1.57363779849313 5.91219248669788e-24 MirTarget -0.28956153342037 6.59691839147703e-07 NA NA NA hsa-miR-140-5p SNAI2 -0.412389003031485 0.000136051708543369 1.57363779849313 5.91219248669788e-24 miRanda -0.309663243070182 2.27741612376817e-06 25322669;27597739 Down regulation of miR 140 induces EMT and promotes invasion by targeting Slug in esophageal cancer; Slug a target gene of miR-140 was examined by luciferase assay and Western blot; miR-140 may regulate the cell invasion of EC via controlling Slug expression;Mechanistically Unigene56159 could directly bind to miR-140-5p and effectively act as a competing endogenous RNA ceRNA for miR-140-5p to de-repress the expression of the target gene Slug ; esophageal cancer;liver cancer hsa-miR-148b-3p SNAI2 0.386859166050437 4.6728211830726e-06 1.57363779849313 5.91219248669788e-24 miRNAWalker2_validate -0.281196118743247 0.000887546987344902 NA NA NA hsa-miR-200b-3p SNAI2 0.0717138787925347 0.682858087587209 1.57363779849313 5.91219248669788e-24 TargetScan -0.308386885932541 7.03084214359139e-15 NA NA NA hsa-miR-200c-3p SNAI2 0.630251054099546 0.000131975031451555 1.57363779849313 5.91219248669788e-24 miRNATAP -0.134398114048252 0.00174621077363836 NA NA NA hsa-miR-330-3p SNAI2 -0.0524949332825773 0.719856123539461 1.57363779849313 5.91219248669788e-24 PITA -0.130033682964608 0.00780041280539171 NA NA NA hsa-miR-335-3p SNAI2 0.336785882180547 0.0542446207938138 1.57363779849313 5.91219248669788e-24 mirMAP -0.144963210468707 0.000354960857720622 NA NA NA hsa-miR-33a-3p SNAI2 0.20371038027126 0.212335697664505 1.57363779849313 5.91219248669788e-24 MirTarget -0.157829857169527 0.000355518332647255 NA NA NA hsa-miR-375 SNAI2 -4.24070205340868 7.48368361454041e-28 1.57363779849313 5.91219248669788e-24 miRanda -0.176728059166066 8.36927466430417e-27 NA NA NA hsa-miR-429 SNAI2 0.559451508722375 0.00563641638673083 1.57363779849313 5.91219248669788e-24 PITA;miRanda;miRNATAP -0.175312757486467 4.8083188190211e-07 NA NA NA hsa-miR-532-5p SNAI2 -0.021857649390892 0.830992272120134 1.57363779849313 5.91219248669788e-24 PITA -0.470416294863014 8.75387306864013e-12 NA NA NA hsa-miR-9-5p SNAI2 1.65694862043766 2.08325802567323e-05 1.57363779849313 5.91219248669788e-24 miRNAWalker2_validate -0.155442431965235 6.55014524540304e-19 NA NA NA hsa-miR-16-1-3p SNTB1 0.955017760172879 5.95379292601146e-11 -1.40504069437352 8.25418635767352e-17 MirTarget;mirMAP -0.422777640100199 1.80448865594539e-17 NA NA NA hsa-miR-16-2-3p SNTB1 1.1567130855258 1.01867256952189e-14 -1.40504069437352 8.25418635767352e-17 mirMAP -0.439751894258599 3.18255699045786e-20 NA NA NA hsa-miR-21-3p SNTB1 1.25126438776674 2.4124216716282e-17 -1.40504069437352 8.25418635767352e-17 mirMAP -0.448634436901608 9.06582777652289e-21 NA NA NA hsa-miR-26b-3p SNTB1 0.421575313079363 0.00223298166810883 -1.40504069437352 8.25418635767352e-17 MirTarget -0.272757387107435 5.8151515264424e-07 NA NA NA hsa-miR-29a-5p SNTB1 0.323252792625584 0.0370417231222825 -1.40504069437352 8.25418635767352e-17 mirMAP -0.127948664173672 0.00905297053017326 NA NA NA hsa-miR-320a SNTB1 0.801356001806321 4.91397101474502e-09 -1.40504069437352 8.25418635767352e-17 MirTarget;miRanda;miRNATAP -0.229269367905107 2.57936954668786e-05 NA NA NA hsa-miR-320b SNTB1 1.23473838180754 3.04337566045537e-14 -1.40504069437352 8.25418635767352e-17 MirTarget;miRanda;miRNATAP -0.210628513185048 3.22797069814585e-06 NA NA NA hsa-miR-330-5p SNTB1 0.944693925383906 5.04972895657346e-13 -1.40504069437352 8.25418635767352e-17 miRanda -0.214166480800658 0.000159504329861863 NA NA NA hsa-miR-33a-3p SNTB1 0.20371038027126 0.212335697664505 -1.40504069437352 8.25418635767352e-17 MirTarget -0.234092314632818 5.81689527486612e-07 NA NA NA hsa-miR-501-5p SNTB1 1.02806906860218 1.63456814370548e-09 -1.40504069437352 8.25418635767352e-17 mirMAP -0.178730745582014 5.38638872970639e-05 NA NA NA hsa-miR-576-5p SNTB1 0.940432050128373 6.90227595663302e-12 -1.40504069437352 8.25418635767352e-17 mirMAP -0.417730743536057 3.17225544625321e-15 NA NA NA hsa-miR-590-3p SNTB1 0.221436901462551 0.0965904764063157 -1.40504069437352 8.25418635767352e-17 MirTarget;miRanda;miRNATAP -0.17879100094571 0.0017383548443783 NA NA NA hsa-miR-590-5p SNTB1 0.763025362395968 3.65305892505623e-09 -1.40504069437352 8.25418635767352e-17 miRanda -0.458218554657537 4.68126225172688e-16 NA NA NA hsa-miR-192-5p SPARC 0.380924502586635 0.00986961967409205 2.00943800777583 1.31063411486708e-19 miRNAWalker2_validate -0.253176365771363 0.000189680747134326 NA NA NA hsa-miR-19a-3p SPARC 1.35800152353624 2.80940447111944e-12 2.00943800777583 1.31063411486708e-19 mirMAP -0.216661773516157 1.6304896851941e-05 NA NA NA hsa-miR-203a-3p SPARC 0.0441399794719697 0.880456392176704 2.00943800777583 1.31063411486708e-19 MirTarget -0.217811118099168 9.31113833677412e-11 NA NA NA hsa-miR-224-3p SPARC 0.502645536188015 0.0081142387260641 2.00943800777583 1.31063411486708e-19 mirMAP -0.253423926261392 1.56250170562299e-06 NA NA NA hsa-miR-29a-3p SPARC -1.26881270980079 2.82496991513463e-22 2.00943800777583 1.31063411486708e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.452295544752526 5.08591552633766e-10 23023935 microRNA 29a suppresses cell proliferation by targeting SPARC in hepatocellular carcinoma; Dual-luciferase reporter assays indicated that the SPARC mRNA 3'UTR was directly targeted by miR-29a since the mutated 3'UTR was not affected; Silencing SPARC expression by RNAi knockdown resulted in a similar effect as miR-29a overexpression on hepatocellular carcinoma HCC cell growth regulation liver cancer hsa-miR-29b-3p SPARC -0.110721443686039 0.511264554091106 2.00943800777583 1.31063411486708e-19 miRNATAP -0.456494072904992 4.26393967161766e-15 NA NA NA hsa-miR-29c-3p SPARC -2.08166260448948 8.3238369390898e-24 2.00943800777583 1.31063411486708e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.37433886368374 8.4608540521934e-17 NA NA NA hsa-miR-362-5p SPARC 0.41089772861323 0.0404254902071382 2.00943800777583 1.31063411486708e-19 TargetScan -0.191196016964408 0.000125306611674513 NA NA NA hsa-miR-374a-3p SPARC -0.299190081500425 0.00682975596757891 2.00943800777583 1.31063411486708e-19 MirTarget -0.254082252402333 0.00533488027346669 NA NA NA hsa-miR-7-1-3p SPARC 1.13646121619622 1.49823237535933e-14 2.00943800777583 1.31063411486708e-19 mirMAP -0.350121348510656 9.51165330315795e-08 NA NA NA hsa-miR-148a-5p SPOCK1 -1.00478606532747 1.38045244999229e-07 0.909471276801658 0.00559136709150591 mirMAP -0.251126910829556 0.000713466577363547 NA NA NA hsa-miR-16-1-3p SPOCK1 0.955017760172879 5.95379292601146e-11 0.909471276801658 0.00559136709150591 MirTarget -0.682884319109725 6.21671769715261e-13 NA NA NA hsa-miR-19a-3p SPOCK1 1.35800152353624 2.80940447111944e-12 0.909471276801658 0.00559136709150591 MirTarget -0.383348750871358 8.24994889038939e-08 NA NA NA hsa-miR-19b-3p SPOCK1 0.538732279378089 0.000622008277870679 0.909471276801658 0.00559136709150591 MirTarget -0.600205566174827 1.79278632858866e-11 NA NA NA hsa-miR-205-3p SPOCK1 1.2960640797621 5.80786479909147e-11 0.909471276801658 0.00559136709150591 mirMAP -0.450825264601216 1.17719963951075e-10 NA NA NA hsa-miR-224-3p SPOCK1 0.502645536188015 0.0081142387260641 0.909471276801658 0.00559136709150591 mirMAP -0.206343129582712 0.00661338468596823 NA NA NA hsa-miR-23a-5p SPOCK1 1.662156284689 7.34844237202118e-15 0.909471276801658 0.00559136709150591 MirTarget -0.179902713890676 0.00662112755113466 NA NA NA hsa-miR-23b-3p SPOCK1 -0.497563803223134 3.31483353357535e-05 0.909471276801658 0.00559136709150591 MirTarget;miRNATAP -0.4985192973768 2.77731887691031e-05 NA NA NA hsa-miR-23b-5p SPOCK1 0.141208007066527 0.420202986869364 0.909471276801658 0.00559136709150591 MirTarget -0.518349617669164 5.03694539271719e-10 NA NA NA hsa-miR-26b-5p SPOCK1 -0.254478038884324 0.0285227763044636 0.909471276801658 0.00559136709150591 mirMAP -0.572048215277119 3.48495509107521e-06 NA NA NA hsa-miR-30d-3p SPOCK1 -0.577371911152798 2.02950840095287e-06 0.909471276801658 0.00559136709150591 mirMAP -0.760576034655535 5.13933144553499e-11 NA NA NA hsa-miR-30e-3p SPOCK1 -0.890635378639789 1.65740480611339e-16 0.909471276801658 0.00559136709150591 mirMAP -0.610134639502482 2.16973355743047e-06 NA NA NA hsa-miR-33a-3p SPOCK1 0.20371038027126 0.212335697664505 0.909471276801658 0.00559136709150591 mirMAP -0.511339649879287 6.78038832728825e-09 NA NA NA hsa-miR-375 SPOCK1 -4.24070205340868 7.48368361454041e-28 0.909471276801658 0.00559136709150591 miRNATAP -0.136245789354302 9.16878130712632e-05 NA NA NA hsa-miR-429 SPOCK1 0.559451508722375 0.00563641638673083 0.909471276801658 0.00559136709150591 miRNATAP -0.447407207439379 1.35677582539181e-10 NA NA NA hsa-miR-454-3p SPOCK1 1.54137391927201 4.15861570449376e-20 0.909471276801658 0.00559136709150591 MirTarget -0.261690388384821 0.00146495780151761 NA NA NA hsa-miR-501-3p SPOCK1 0.820141346319976 1.74562930463389e-08 0.909471276801658 0.00559136709150591 PITA;TargetScan;miRNATAP -0.318558699261452 0.00107880517574818 NA NA NA hsa-miR-502-3p SPOCK1 -0.165138869760313 0.106881047403914 0.909471276801658 0.00559136709150591 PITA;miRNATAP -0.456227602362426 0.00122899236962929 NA NA NA hsa-miR-582-5p SPOCK1 -0.0366995972742474 0.821827119138923 0.909471276801658 0.00559136709150591 PITA;miRNATAP -0.583800228759663 1.66173712089405e-11 NA NA NA hsa-miR-590-3p SPOCK1 0.221436901462551 0.0965904764063157 0.909471276801658 0.00559136709150591 PITA;miRanda;mirMAP -0.548073296675695 3.11226820460801e-07 NA NA NA hsa-miR-590-5p SPOCK1 0.763025362395968 3.65305892505623e-09 0.909471276801658 0.00559136709150591 MirTarget;miRanda;mirMAP -0.583148662129345 7.88684351625264e-08 NA NA NA hsa-miR-629-3p SPOCK1 1.43262037314105 2.37092217984413e-19 0.909471276801658 0.00559136709150591 MirTarget -0.448640397690553 1.96795215340173e-07 NA NA NA hsa-miR-139-5p SPP1 -1.46099200329485 7.85040381494472e-22 3.13698287810329 2.52711273098143e-16 miRanda -0.982468197986807 5.945578026932e-21 NA NA NA hsa-miR-335-5p SPP1 -1.17227779671552 1.49282618530733e-10 3.13698287810329 2.52711273098143e-16 miRNAWalker2_validate -0.297441724953532 0.00126731967128808 NA NA NA hsa-miR-362-3p SPP1 -0.697212068252854 2.61718493418184e-06 3.13698287810329 2.52711273098143e-16 miRanda -0.503490269497998 1.20718234999541e-05 NA NA NA hsa-miR-7-5p TAGLN 1.55674721532755 2.41989824363914e-11 0.210910601280222 0.357625679539394 miRNAWalker2_validate -0.137705217308657 0.00177070445040749 NA NA NA hsa-miR-940 TAGLN 1.25303020594374 1.3005368359451e-10 0.210910601280222 0.357625679539394 MirTarget;PITA;miRNATAP -0.138628645965198 0.00649245179660368 NA NA NA hsa-miR-23b-3p TFPI2 -0.497563803223134 3.31483353357535e-05 0.577025460360282 0.171958251647605 MirTarget;miRNATAP -0.468509380760441 0.00223954087653997 NA NA NA hsa-miR-139-5p TGFB1 -1.46099200329485 7.85040381494472e-22 1.63261254184582 2.57292771878501e-37 miRanda -0.211396728970549 1.66114173348681e-08 NA NA NA hsa-miR-29b-3p TGFB1 -0.110721443686039 0.511264554091106 1.63261254184582 2.57292771878501e-37 miRTarBase -0.115557141630177 0.00118189427407973 NA NA NA hsa-miR-26b-5p TGFBI -0.254478038884324 0.0285227763044636 2.96842077099196 5.42111172373249e-26 miRNAWalker2_validate -0.47760119035675 1.73313031007438e-05 NA NA NA hsa-miR-30a-5p TGFBI -1.79779915425811 1.93360169837799e-26 2.96842077099196 5.42111172373249e-26 miRNAWalker2_validate -0.545077010044602 1.50734932970056e-14 NA NA NA hsa-miR-362-3p TGFBI -0.697212068252854 2.61718493418184e-06 2.96842077099196 5.42111172373249e-26 miRanda -0.292696388328077 0.000731123084474543 NA NA NA hsa-miR-429 TGFBI 0.559451508722375 0.00563641638673083 2.96842077099196 5.42111172373249e-26 miRanda -0.399907436981469 1.8541901793279e-10 NA NA NA hsa-miR-9-5p TGFBI 1.65694862043766 2.08325802567323e-05 2.96842077099196 5.42111172373249e-26 miRNAWalker2_validate;miRTarBase -0.30269418889601 8.93406688744962e-22 NA NA NA hsa-miR-15a-5p TGFBR3 0.783550182002274 2.60699595655907e-11 -2.33775701333658 1.4292781203639e-22 MirTarget;miRNATAP -0.649423432301841 3.84732333165554e-13 NA NA NA hsa-miR-15b-5p TGFBR3 0.85315666454713 3.79816274836297e-12 -2.33775701333658 1.4292781203639e-22 MirTarget;miRNATAP -0.262909121448377 0.00254854214224796 NA NA NA hsa-miR-16-2-3p TGFBR3 1.1567130855258 1.01867256952189e-14 -2.33775701333658 1.4292781203639e-22 mirMAP -0.392763412174948 2.2784891564096e-08 NA NA NA hsa-miR-16-5p TGFBR3 0.521122945828175 1.40561786410572e-06 -2.33775701333658 1.4292781203639e-22 MirTarget;miRNATAP -0.288490449441108 0.00412228400433026 NA NA NA hsa-miR-181a-5p TGFBR3 0.819060835827404 1.38616688310277e-13 -2.33775701333658 1.4292781203639e-22 miRNAWalker2_validate;mirMAP;miRNATAP -0.481161973455912 5.13177365519917e-07 NA NA NA hsa-miR-181b-5p TGFBR3 0.974255518824355 2.64876280203475e-16 -2.33775701333658 1.4292781203639e-22 mirMAP -0.650006419850336 9.47730765634074e-14 NA NA NA hsa-miR-186-5p TGFBR3 0.353452958261612 0.000145058448579496 -2.33775701333658 1.4292781203639e-22 MirTarget -0.461626791003898 8.32887014485828e-05 NA NA NA hsa-miR-18a-3p TGFBR3 1.82583720936229 7.51297960972179e-19 -2.33775701333658 1.4292781203639e-22 MirTarget -0.316260423974977 9.38562501878288e-10 NA NA NA hsa-miR-18a-5p TGFBR3 1.65455873230328 3.76457892277775e-20 -2.33775701333658 1.4292781203639e-22 MirTarget -0.43252036938629 2.91936769758989e-14 NA NA NA hsa-miR-193a-3p TGFBR3 0.22120710726779 0.111827069464729 -2.33775701333658 1.4292781203639e-22 MirTarget;miRanda;miRNATAP -0.559948272931618 3.23084375018462e-13 NA NA NA hsa-miR-193b-3p TGFBR3 1.72788400801602 3.0722151264559e-21 -2.33775701333658 1.4292781203639e-22 miRNAWalker2_validate;MirTarget;miRNATAP -0.624709682577051 5.6021228518868e-31 NA NA NA hsa-miR-21-5p TGFBR3 1.62465922021121 3.44191300985109e-58 -2.33775701333658 1.4292781203639e-22 miRNAWalker2_validate -1.04907878363987 1.11926077262689e-30 NA NA NA hsa-miR-27a-3p TGFBR3 0.348456440505425 0.00126682892514312 -2.33775701333658 1.4292781203639e-22 MirTarget;miRNATAP -0.271051865314538 0.00737876652969619 NA NA NA hsa-miR-29a-5p TGFBR3 0.323252792625584 0.0370417231222825 -2.33775701333658 1.4292781203639e-22 mirMAP -0.28088701682147 6.08590951389061e-05 NA NA NA hsa-miR-339-5p TGFBR3 1.07771430326938 2.45772601859307e-09 -2.33775701333658 1.4292781203639e-22 miRanda -0.310476677751781 1.29050976642217e-07 NA NA NA hsa-miR-3607-3p TGFBR3 1.01377165357363 9.13355519701165e-05 -2.33775701333658 1.4292781203639e-22 mirMAP -0.150048488640653 0.00031564641483518 NA NA NA hsa-miR-424-5p TGFBR3 1.48125289532143 9.10372985713165e-19 -2.33775701333658 1.4292781203639e-22 MirTarget;miRNATAP -0.472557458706331 1.28030826322785e-14 NA NA NA hsa-miR-450b-5p TGFBR3 1.25529820885833 1.18847120528666e-15 -2.33775701333658 1.4292781203639e-22 mirMAP -0.400335621740456 1.92870135526974e-09 NA NA NA hsa-miR-455-5p TGFBR3 1.408595672323 5.52039116456697e-22 -2.33775701333658 1.4292781203639e-22 miRanda -0.817784013693157 3.0691058383061e-34 NA NA NA hsa-miR-484 TGFBR3 0.918280909791707 1.39168306854263e-14 -2.33775701333658 1.4292781203639e-22 MirTarget;miRNATAP -0.246338322872403 0.00584052894071287 NA NA NA hsa-miR-589-3p TGFBR3 1.59559692667315 6.2886410639161e-15 -2.33775701333658 1.4292781203639e-22 MirTarget -0.311842535860169 4.80435029808815e-09 NA NA NA hsa-miR-590-5p TGFBR3 0.763025362395968 3.65305892505623e-09 -2.33775701333658 1.4292781203639e-22 miRanda -0.431850003764857 1.65091443898854e-07 NA NA NA hsa-miR-7-1-3p TGFBR3 1.13646121619622 1.49823237535933e-14 -2.33775701333658 1.4292781203639e-22 mirMAP -0.281127891464509 8.70035498981649e-05 NA NA NA hsa-miR-944 TGFBR3 1.47323925060177 2.61626403984929e-13 -2.33775701333658 1.4292781203639e-22 mirMAP -0.190248797037249 0.000300434783380661 NA NA NA hsa-miR-17-5p TGM2 1.41924888736771 2.75805544953758e-18 0.557834301486876 0.0211475279223604 MirTarget -0.276432830347591 9.50649118784141e-06 NA NA NA hsa-miR-20a-5p TGM2 1.1531986665452 1.02385132917958e-11 0.557834301486876 0.0211475279223604 MirTarget -0.312042514305842 2.56101814913804e-07 NA NA NA hsa-miR-93-5p TGM2 1.61042951896619 5.1280369606967e-24 0.557834301486876 0.0211475279223604 MirTarget -0.276464645593556 1.14798798400966e-05 NA NA NA hsa-let-7a-3p THBS1 0.0966652362351867 0.423761916840503 -0.0602688709574686 0.817102472377875 mirMAP -0.257626055880682 0.00641628779702676 NA NA NA hsa-miR-155-5p THBS1 0.533437622040649 0.00248671179205372 -0.0602688709574686 0.817102472377875 miRNAWalker2_validate;mirMAP -0.17476722608862 0.006488079922108 NA NA NA hsa-miR-16-1-3p THBS1 0.955017760172879 5.95379292601146e-11 -0.0602688709574686 0.817102472377875 MirTarget -0.500955283959431 2.92731476405759e-11 NA NA NA hsa-miR-17-5p THBS1 1.41924888736771 2.75805544953758e-18 -0.0602688709574686 0.817102472377875 miRNAWalker2_validate -0.381344928892176 1.05498288528831e-08 NA NA NA hsa-miR-181c-5p THBS1 -0.168991199007857 0.196949106150297 -0.0602688709574686 0.817102472377875 mirMAP -0.247983674823625 0.00437646006301906 NA NA NA hsa-miR-182-5p THBS1 1.15060905311096 6.25565852529946e-10 -0.0602688709574686 0.817102472377875 MirTarget -0.309873212711269 1.84640622484898e-07 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-18a-5p THBS1 1.65455873230328 3.76457892277775e-20 -0.0602688709574686 0.817102472377875 MirTarget -0.24726989244349 4.30044680655473e-05 NA NA NA hsa-miR-19a-3p THBS1 1.35800152353624 2.80940447111944e-12 -0.0602688709574686 0.817102472377875 MirTarget;mirMAP -0.414578771692538 1.14486667604464e-13 NA NA NA hsa-miR-19b-3p THBS1 0.538732279378089 0.000622008277870679 -0.0602688709574686 0.817102472377875 MirTarget;mirMAP -0.579635022619252 1.04471069287289e-16 NA NA NA hsa-miR-200a-5p THBS1 0.701063526850019 0.000188402923774663 -0.0602688709574686 0.817102472377875 MirTarget -0.493887203406803 2.53713541729748e-17 NA NA NA hsa-miR-200b-5p THBS1 0.02621402664548 0.883725338810228 -0.0602688709574686 0.817102472377875 MirTarget -0.429279995414032 5.28189107350755e-12 NA NA NA hsa-miR-20a-5p THBS1 1.1531986665452 1.02385132917958e-11 -0.0602688709574686 0.817102472377875 miRNAWalker2_validate -0.475131098210825 1.34284170648631e-13 NA NA NA hsa-miR-32-5p THBS1 -0.317310201890053 0.0102525324475293 -0.0602688709574686 0.817102472377875 mirMAP -0.348384610454154 0.00014766125359508 NA NA NA hsa-miR-33a-3p THBS1 0.20371038027126 0.212335697664505 -0.0602688709574686 0.817102472377875 MirTarget;mirMAP -0.397919916365233 1.19875077545057e-08 NA NA NA hsa-miR-500a-5p THBS1 0.675401699376111 8.24389004707854e-05 -0.0602688709574686 0.817102472377875 mirMAP -0.36725155536225 1.649731351533e-08 NA NA NA hsa-miR-576-5p THBS1 0.940432050128373 6.90227595663302e-12 -0.0602688709574686 0.817102472377875 mirMAP -0.255507850086054 0.00165862768717641 NA NA NA hsa-miR-589-3p THBS1 1.59559692667315 6.2886410639161e-15 -0.0602688709574686 0.817102472377875 mirMAP -0.170472312541131 0.0024064977779302 NA NA NA hsa-miR-590-5p THBS1 0.763025362395968 3.65305892505623e-09 -0.0602688709574686 0.817102472377875 miRanda;mirMAP -0.520750608832199 1.15560113303924e-09 NA NA NA hsa-miR-629-3p THBS1 1.43262037314105 2.37092217984413e-19 -0.0602688709574686 0.817102472377875 MirTarget -0.264076289477301 0.00011856285955883 NA NA NA hsa-miR-664a-3p THBS1 -0.256108763664991 0.0513188660751664 -0.0602688709574686 0.817102472377875 mirMAP -0.396960198069835 4.00846362134978e-06 NA NA NA hsa-miR-7-1-3p THBS1 1.13646121619622 1.49823237535933e-14 -0.0602688709574686 0.817102472377875 MirTarget;mirMAP -0.403917251404343 5.0859524726101e-08 NA NA NA hsa-miR-92a-3p THBS1 0.994679542307232 1.32587679156217e-16 -0.0602688709574686 0.817102472377875 miRNAWalker2_validate -0.672834298334846 7.04881253821255e-14 NA NA NA hsa-miR-106a-5p THBS2 0.67978010057847 0.00221925869726092 1.62618248595017 5.83385949124459e-09 MirTarget -0.498038651519378 1.0423338841424e-20 NA NA NA hsa-miR-106b-5p THBS2 0.50378717276868 1.45412404526866e-05 1.62618248595017 5.83385949124459e-09 MirTarget -0.520299545803915 7.89973482462783e-07 NA NA NA hsa-miR-142-5p THBS2 0.288897753038094 0.0900009317815725 1.62618248595017 5.83385949124459e-09 mirMAP -0.286021179500209 7.68382546528818e-05 NA NA NA hsa-miR-16-2-3p THBS2 1.1567130855258 1.01867256952189e-14 1.62618248595017 5.83385949124459e-09 mirMAP -0.695934931312402 4.38390463808463e-19 NA NA NA hsa-miR-17-5p THBS2 1.41924888736771 2.75805544953758e-18 1.62618248595017 5.83385949124459e-09 MirTarget;TargetScan -0.386282137212615 1.10388771192053e-07 NA NA NA hsa-miR-20a-5p THBS2 1.1531986665452 1.02385132917958e-11 1.62618248595017 5.83385949124459e-09 MirTarget -0.441807863444289 3.56122890496723e-10 NA NA NA hsa-miR-20b-5p THBS2 0.345967670847176 0.232014828043601 1.62618248595017 5.83385949124459e-09 MirTarget -0.386757637243133 4.89685171657703e-21 NA NA NA hsa-miR-29a-3p THBS2 -1.26881270980079 2.82496991513463e-22 1.62618248595017 5.83385949124459e-09 MirTarget -0.375971052620663 3.27406128446898e-05 NA NA NA hsa-miR-29b-3p THBS2 -0.110721443686039 0.511264554091106 1.62618248595017 5.83385949124459e-09 MirTarget -0.604035666487595 2.42231935501019e-17 NA NA NA hsa-miR-29c-3p THBS2 -2.08166260448948 8.3238369390898e-24 1.62618248595017 5.83385949124459e-09 MirTarget -0.383432822523996 7.31542489520432e-12 NA NA NA hsa-miR-320a THBS2 0.801356001806321 4.91397101474502e-09 1.62618248595017 5.83385949124459e-09 mirMAP -0.333738172381151 0.000174825842344476 NA NA NA hsa-miR-320b THBS2 1.23473838180754 3.04337566045537e-14 1.62618248595017 5.83385949124459e-09 mirMAP -0.253915498040408 0.000606797171209941 NA NA NA hsa-miR-335-3p THBS2 0.336785882180547 0.0542446207938138 1.62618248595017 5.83385949124459e-09 MirTarget;mirMAP -0.205075913442286 0.00369881790334179 NA NA NA hsa-miR-582-3p THBS2 -0.248056267546012 0.143798829508405 1.62618248595017 5.83385949124459e-09 miRNATAP -0.614582447701426 3.28736839956178e-18 NA NA NA hsa-miR-590-3p THBS2 0.221436901462551 0.0965904764063157 1.62618248595017 5.83385949124459e-09 miRanda;mirMAP -0.490631194415479 1.03044076631118e-07 NA NA NA hsa-miR-590-5p THBS2 0.763025362395968 3.65305892505623e-09 1.62618248595017 5.83385949124459e-09 miRanda -0.606004824335812 7.10608278095606e-11 NA NA NA hsa-miR-598-3p THBS2 -0.501551607314861 0.00273752172874978 1.62618248595017 5.83385949124459e-09 MirTarget -0.247403867800378 0.000771969489446281 NA NA NA hsa-miR-7-1-3p THBS2 1.13646121619622 1.49823237535933e-14 1.62618248595017 5.83385949124459e-09 MirTarget;mirMAP -0.49189242601595 9.78785576248441e-10 NA NA NA hsa-miR-9-5p THBS2 1.65694862043766 2.08325802567323e-05 1.62618248595017 5.83385949124459e-09 miRNATAP -0.189182675409391 1.04224055895548e-09 NA NA NA hsa-miR-93-5p THBS2 1.61042951896619 5.1280369606967e-24 1.62618248595017 5.83385949124459e-09 MirTarget -0.32493483850462 1.05176746904084e-05 NA NA NA hsa-miR-96-5p THBS2 1.42326703011157 4.39736150032373e-14 1.62618248595017 5.83385949124459e-09 TargetScan;miRNATAP -0.223958633163457 0.000445050719007805 NA NA NA hsa-miR-338-3p THY1 -0.948755228846395 8.99167125682392e-08 2.23758091267826 1.36823466486189e-22 mirMAP -0.258032231412867 7.72563914775632e-06 NA NA NA hsa-let-7a-3p TIMP3 0.0966652362351867 0.423761916840503 -0.108564734035578 0.663080057862363 mirMAP;miRNATAP -0.263218958251824 0.00357148966148464 NA NA NA hsa-let-7f-1-3p TIMP3 0.700374242293247 8.65000484720084e-08 -0.108564734035578 0.663080057862363 mirMAP -0.252280372844269 0.00214222871228041 NA NA NA hsa-miR-101-3p TIMP3 -1.91263766544878 1.50270129259053e-39 -0.108564734035578 0.663080057862363 miRNATAP -0.205454470751797 0.00294817212050278 NA NA NA hsa-miR-103a-3p TIMP3 0.556219385347418 1.55815736455067e-09 -0.108564734035578 0.663080057862363 miRNAWalker2_validate;miRTarBase -0.356911668669704 0.00232060899354011 22783422 miR-103 inhibitor transfection increased the activity of the luciferase reporter assay containing the TIMP-3 3'-untranslated region UTR construct and increased the levels of the TIMP-3 protein but not its mRNA in endometrial cancer cell lines; Our data suggested that miR-103 post-transcriptionally downregulates the expression of the tumor suppressor TIMP-3 and stimulates growth and invasion in endometrial cancer cell lines endometrial cancer hsa-miR-106a-5p TIMP3 0.67978010057847 0.00221925869726092 -0.108564734035578 0.663080057862363 miRNATAP -0.429198039721658 5.87714259170297e-20 NA NA NA hsa-miR-106b-5p TIMP3 0.50378717276868 1.45412404526866e-05 -0.108564734035578 0.663080057862363 miRNATAP -0.68081929312847 7.9645681418409e-14 NA NA NA hsa-miR-148a-5p TIMP3 -1.00478606532747 1.38045244999229e-07 -0.108564734035578 0.663080057862363 mirMAP -0.146693071577087 0.0091074225777052 NA NA NA hsa-miR-16-1-3p TIMP3 0.955017760172879 5.95379292601146e-11 -0.108564734035578 0.663080057862363 mirMAP -0.654093693221854 2.0664538249871e-20 NA NA NA hsa-miR-16-5p TIMP3 0.521122945828175 1.40561786410572e-06 -0.108564734035578 0.663080057862363 miRNAWalker2_validate -0.785344769586078 8.23183392192967e-16 NA NA NA hsa-miR-188-5p TIMP3 0.559328953885106 0.000430338888594543 -0.108564734035578 0.663080057862363 mirMAP -0.357901098352287 1.26207820618343e-07 NA NA NA hsa-miR-20a-5p TIMP3 1.1531986665452 1.02385132917958e-11 -0.108564734035578 0.663080057862363 miRNATAP -0.511472059443363 4.69962258752056e-17 NA NA NA hsa-miR-222-3p TIMP3 1.08197052578759 2.32604040301699e-14 -0.108564734035578 0.663080057862363 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.276381724833968 0.000209354437642993 NA NA NA hsa-miR-30c-5p TIMP3 0.021222006155897 0.886366656528128 -0.108564734035578 0.663080057862363 miRNATAP -0.351890383765733 1.33757080820726e-06 NA NA NA hsa-miR-30d-5p TIMP3 -0.38399848121878 0.000171129616944749 -0.108564734035578 0.663080057862363 miRNATAP -0.486552121896622 4.32841520756186e-06 NA NA NA hsa-miR-3607-3p TIMP3 1.01377165357363 9.13355519701165e-05 -0.108564734035578 0.663080057862363 MirTarget;miRNATAP -0.2599266295082 2.2330828603385e-10 NA NA NA hsa-miR-423-5p TIMP3 0.60141781325829 1.62940950644999e-07 -0.108564734035578 0.663080057862363 miRNAWalker2_validate -0.295932615741537 0.00161922846956563 NA NA NA hsa-miR-505-3p TIMP3 0.912823669571645 4.0549774967148e-13 -0.108564734035578 0.663080057862363 mirMAP -0.480859729475641 8.75137241925835e-09 NA NA NA hsa-miR-589-3p TIMP3 1.59559692667315 6.2886410639161e-15 -0.108564734035578 0.663080057862363 mirMAP -0.262497408474909 8.56738740543383e-07 NA NA NA hsa-miR-590-3p TIMP3 0.221436901462551 0.0965904764063157 -0.108564734035578 0.663080057862363 PITA;miRanda;miRNATAP -0.457852107557831 1.4516707008617e-08 NA NA NA hsa-miR-590-5p TIMP3 0.763025362395968 3.65305892505623e-09 -0.108564734035578 0.663080057862363 MirTarget;PITA;miRanda;miRNATAP -0.649384624097779 8.92302101097578e-16 NA NA NA hsa-miR-660-5p TIMP3 -0.202705992887645 0.101093376073573 -0.108564734035578 0.663080057862363 miRNATAP -0.482415487437097 3.22477114371984e-08 NA NA NA hsa-miR-7-1-3p TIMP3 1.13646121619622 1.49823237535933e-14 -0.108564734035578 0.663080057862363 mirMAP -0.650879857128633 3.68082670704093e-21 NA NA NA hsa-miR-126-5p TNC -0.953529188793816 7.91719143295591e-16 1.86114864094287 6.8600650455825e-11 miRNATAP -0.2840974784557 0.00659749428791764 NA NA NA hsa-miR-335-5p TNC -1.17227779671552 1.49282618530733e-10 1.86114864094287 6.8600650455825e-11 miRNAWalker2_validate;miRTarBase -0.206395559501656 0.00240544523157137 NA NA NA hsa-miR-9-5p TNC 1.65694862043766 2.08325802567323e-05 1.86114864094287 6.8600650455825e-11 MirTarget;miRNATAP -0.23822061428961 3.88765669970334e-14 NA NA NA hsa-miR-125b-5p TNFAIP3 -0.993460109818276 5.07736727659894e-12 0.884179481412877 5.34745628158925e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.171763306094484 0.00116941571998158 24901050 miR 125b controls apoptosis and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomas; GBM cells overexpressing TNFAIP3 and NKIRAS2 were refractory to miR-125b-induced apoptosis resistance as well as TMZ resistance indicating that both genes are relevant targets of miR-125b drug resistance glioblastoma hsa-miR-200c-3p TNFRSF11B 0.630251054099546 0.000131975031451555 0.020841930854977 0.937136555074824 miRNATAP -0.195617822216338 0.00487181909386761 NA NA NA hsa-miR-429 TNFRSF11B 0.559451508722375 0.00563641638673083 0.020841930854977 0.937136555074824 PITA;miRanda;miRNATAP -0.197112372573267 0.000504393969368701 NA NA NA hsa-miR-576-5p TNFRSF11B 0.940432050128373 6.90227595663302e-12 0.020841930854977 0.937136555074824 PITA -0.349384021839919 2.06096475616522e-05 NA NA NA hsa-miR-590-5p TNFRSF11B 0.763025362395968 3.65305892505623e-09 0.020841930854977 0.937136555074824 PITA;miRanda;miRNATAP -0.297195480374457 0.000714600151291304 NA NA NA hsa-miR-16-5p TNFRSF12A 0.521122945828175 1.40561786410572e-06 1.57834397668403 1.67961841432292e-15 miRNAWalker2_validate -0.21320067728609 0.00945832471700254 NA NA NA hsa-miR-107 TPM1 -0.0447040564279497 0.671618791096755 -0.242102367153747 0.260522670026029 PITA;miRanda -0.284285522960317 0.00151441396516866 NA NA NA hsa-miR-142-3p TPM1 1.12754191614028 1.68798138028946e-08 -0.242102367153747 0.260522670026029 miRanda -0.267018036839686 4.98407461559576e-09 NA NA NA hsa-miR-183-5p TPM1 1.4313129319945 6.25230916431996e-14 -0.242102367153747 0.260522670026029 MirTarget;miRNATAP -0.172023867634965 0.000318517125524878 NA NA NA hsa-miR-29b-3p TPM1 -0.110721443686039 0.511264554091106 -0.242102367153747 0.260522670026029 miRNATAP -0.167646968418546 0.0026104554989598 NA NA NA hsa-miR-29c-3p TPM1 -2.08166260448948 8.3238369390898e-24 -0.242102367153747 0.260522670026029 miRNATAP -0.178245166813483 3.45005059456117e-05 NA NA NA hsa-miR-320a TPM1 0.801356001806321 4.91397101474502e-09 -0.242102367153747 0.260522670026029 miRanda -0.177102147904146 0.00885958577828951 NA NA NA hsa-miR-320b TPM1 1.23473838180754 3.04337566045537e-14 -0.242102367153747 0.260522670026029 miRanda -0.288975103289791 2.18019427867598e-07 NA NA NA hsa-miR-33a-3p TPM1 0.20371038027126 0.212335697664505 -0.242102367153747 0.260522670026029 miRNATAP -0.416065516186756 3.19631073050282e-13 NA NA NA hsa-miR-34a-5p TPM1 -0.117372471043915 0.364001947180738 -0.242102367153747 0.260522670026029 miRNAWalker2_validate -0.263594834776541 0.0002869394587574 NA NA NA hsa-miR-375 TPM1 -4.24070205340868 7.48368361454041e-28 -0.242102367153747 0.260522670026029 miRanda -0.110164868890237 1.17133111808707e-06 NA NA NA hsa-miR-429 TPM1 0.559451508722375 0.00563641638673083 -0.242102367153747 0.260522670026029 miRNATAP -0.421443742341922 2.78348931408059e-21 NA NA NA hsa-miR-590-3p TPM1 0.221436901462551 0.0965904764063157 -0.242102367153747 0.260522670026029 miRanda -0.22997401243321 0.00110652224494141 NA NA NA hsa-miR-944 TPM1 1.47323925060177 2.61626403984929e-13 -0.242102367153747 0.260522670026029 mirMAP -0.229824932416746 3.29804157872108e-07 NA NA NA hsa-miR-96-5p TPM1 1.42326703011157 4.39736150032373e-14 -0.242102367153747 0.260522670026029 MirTarget;TargetScan;miRNATAP -0.230821198258102 1.60371907723313e-06 NA NA NA hsa-miR-15b-5p TPM2 0.85315666454713 3.79816274836297e-12 -1.26161693533437 9.79888756958376e-06 MirTarget -0.69893357744647 1.2086206200998e-12 NA NA NA hsa-miR-16-5p TPM2 0.521122945828175 1.40561786410572e-06 -1.26161693533437 9.79888756958376e-06 MirTarget -0.561990556100409 1.01252198500933e-06 NA NA NA hsa-miR-185-5p TPM2 0.675225177054909 1.84953949190805e-13 -1.26161693533437 9.79888756958376e-06 MirTarget -0.490340677626431 0.000268896268871351 NA NA NA hsa-miR-320b TPM2 1.23473838180754 3.04337566045537e-14 -1.26161693533437 9.79888756958376e-06 miRanda -0.415997012523244 2.2948670532141e-08 NA NA NA hsa-miR-423-5p TPM2 0.60141781325829 1.62940950644999e-07 -1.26161693533437 9.79888756958376e-06 miRNATAP -0.373044962719235 0.00057863187795132 NA NA NA hsa-miR-96-5p TPM2 1.42326703011157 4.39736150032373e-14 -1.26161693533437 9.79888756958376e-06 TargetScan -0.42529173673487 2.47821786158248e-11 NA NA NA hsa-miR-192-5p TPM4 0.380924502586635 0.00986961967409205 0.0626616582248491 0.516374121207015 miRNAWalker2_validate -0.132973325690892 2.47347800631306e-06 NA NA NA hsa-miR-30a-5p TPM4 -1.79779915425811 1.93360169837799e-26 0.0626616582248491 0.516374121207015 miRNATAP -0.130878623510706 2.01683607107756e-08 NA NA NA hsa-miR-30c-5p TPM4 0.021222006155897 0.886366656528128 0.0626616582248491 0.516374121207015 miRNATAP -0.159614381299512 1.21295832690195e-08 NA NA NA hsa-miR-30d-5p TPM4 -0.38399848121878 0.000171129616944749 0.0626616582248491 0.516374121207015 miRNATAP -0.302362402476792 5.78692777193334e-14 NA NA NA hsa-miR-320a TPM4 0.801356001806321 4.91397101474502e-09 0.0626616582248491 0.516374121207015 PITA;miRanda -0.130117798236427 1.54506306540472e-05 NA NA NA hsa-let-7a-3p VCAM1 0.0966652362351867 0.423761916840503 0.304945578714638 0.303709176441742 MirTarget -0.565309168397432 1.1203182800872e-07 NA NA NA hsa-miR-200a-3p VCAM1 0.607140814457753 0.00289840524858752 0.304945578714638 0.303709176441742 miRNAWalker2_validate -0.366476779245168 4.18259687858775e-09 NA NA NA hsa-miR-22-5p VCAM1 0.706731861922839 3.44318705980007e-07 0.304945578714638 0.303709176441742 MirTarget -0.293703135809404 0.00146891253806599 NA NA NA hsa-miR-590-5p VCAM1 0.763025362395968 3.65305892505623e-09 0.304945578714638 0.303709176441742 miRanda -0.436711642856802 8.71166840484585e-06 NA NA NA hsa-miR-944 VCAM1 1.47323925060177 2.61626403984929e-13 0.304945578714638 0.303709176441742 mirMAP;miRNATAP -0.43094977097199 2.16600511737959e-12 NA NA NA hsa-let-7a-3p VCAN 0.0966652362351867 0.423761916840503 1.6094024557674 2.62252187578953e-08 MirTarget -0.450075030488377 2.14375238096033e-05 NA NA NA hsa-miR-101-3p VCAN -1.91263766544878 1.50270129259053e-39 1.6094024557674 2.62252187578953e-08 miRNATAP -0.211319585872581 0.00949514175434177 NA NA NA hsa-miR-126-5p VCAN -0.953529188793816 7.91719143295591e-16 1.6094024557674 2.62252187578953e-08 mirMAP -0.350068224507769 0.000881160751144529 NA NA NA hsa-miR-135b-5p VCAN 1.5570143078477 4.60753610971455e-13 1.6094024557674 2.62252187578953e-08 MirTarget -0.380664742843929 2.36926223213113e-11 NA NA NA hsa-miR-141-3p VCAN 0.730011517758706 0.000120338355004032 1.6094024557674 2.62252187578953e-08 MirTarget;TargetScan;miRNATAP -0.628131260209182 1.37533052151244e-22 NA NA NA hsa-miR-144-3p VCAN -1.64994343636831 1.13169944841075e-08 1.6094024557674 2.62252187578953e-08 miRNATAP -0.115779154098214 0.00783146457083294 NA NA NA hsa-miR-16-2-3p VCAN 1.1567130855258 1.01867256952189e-14 1.6094024557674 2.62252187578953e-08 mirMAP -0.693732787872831 9.27501168183136e-18 NA NA NA hsa-miR-186-5p VCAN 0.353452958261612 0.000145058448579496 1.6094024557674 2.62252187578953e-08 MirTarget;miRNATAP -0.621332705501648 6.07871979029455e-06 NA NA NA hsa-miR-200a-3p VCAN 0.607140814457753 0.00289840524858752 1.6094024557674 2.62252187578953e-08 MirTarget;miRNATAP -0.622839409978078 1.39004792476377e-25 NA NA NA hsa-miR-203a-3p VCAN 0.0441399794719697 0.880456392176704 1.6094024557674 2.62252187578953e-08 MirTarget -0.317619151676025 8.19209157113022e-14 NA NA NA hsa-miR-223-5p VCAN 0.119850522837464 0.593378022605214 1.6094024557674 2.62252187578953e-08 MirTarget -0.182842344253381 0.00132289485330915 NA NA NA hsa-miR-224-3p VCAN 0.502645536188015 0.0081142387260641 1.6094024557674 2.62252187578953e-08 MirTarget -0.349374116852504 1.88267220916458e-07 NA NA NA hsa-miR-23b-3p VCAN -0.497563803223134 3.31483353357535e-05 1.6094024557674 2.62252187578953e-08 MirTarget;miRNATAP -0.274931171487185 0.00984880810975525 NA NA NA hsa-miR-33a-3p VCAN 0.20371038027126 0.212335697664505 1.6094024557674 2.62252187578953e-08 mirMAP -0.439595567354977 2.30515326634506e-08 NA NA NA hsa-miR-33a-5p VCAN 1.12988965056352 3.35742517382153e-07 1.6094024557674 2.62252187578953e-08 MirTarget -0.348558638063875 5.58344887869661e-10 NA NA NA hsa-miR-33b-5p VCAN 0.681845193600723 0.00407790722487864 1.6094024557674 2.62252187578953e-08 MirTarget -0.267371606125788 1.10394589350267e-06 NA NA NA hsa-miR-361-3p VCAN 0.272298288982435 0.0147874880476998 1.6094024557674 2.62252187578953e-08 miRNATAP -0.518548269387456 5.73526169945397e-06 NA NA NA hsa-miR-429 VCAN 0.559451508722375 0.00563641638673083 1.6094024557674 2.62252187578953e-08 miRanda -0.525399248104758 8.326695504938e-18 NA NA NA hsa-miR-590-3p VCAN 0.221436901462551 0.0965904764063157 1.6094024557674 2.62252187578953e-08 miRanda -0.502104319137635 1.39663834412154e-07 NA NA NA hsa-miR-664a-3p VCAN -0.256108763664991 0.0513188660751664 1.6094024557674 2.62252187578953e-08 mirMAP -0.280322900398569 0.00406462601328179 NA NA NA hsa-miR-9-5p VCAN 1.65694862043766 2.08325802567323e-05 1.6094024557674 2.62252187578953e-08 MirTarget;miRNATAP -0.107677650784137 0.000906672029511467 NA NA NA hsa-miR-101-3p VEGFA -1.91263766544878 1.50270129259053e-39 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate -0.281477062331858 8.81075776241686e-11 NA NA NA hsa-miR-134-5p VEGFA -0.598302069876985 0.00124773585997939 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.114375387301794 0.00210306889630562 NA NA NA hsa-miR-140-5p VEGFA -0.412389003031485 0.000136051708543369 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.268410061738275 2.63838447575462e-05 26402430 MicroRNA 140 5p inhibits the progression of colorectal cancer by targeting VEGFA; The direct regulation of VEGFA by miR-140-5p was identified using luciferase reporter assay; Integrated analysis identified VEGFA as a direct and functional target gene of miR-140-5p; Silencing VEGFA by small interfering RNA siRNA resembled the phenotype resulting from ectopic miR-140-5p expression while overexpression of VEGFA attenuated the effect of miR-140-5p on CRC cells; Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA progression;tumorigenesis colorectal cancer hsa-miR-150-5p VEGFA -0.243749814009231 0.331546276920338 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase -0.1837154779422 1.13782348414927e-11 NA NA NA hsa-miR-195-5p VEGFA -1.8367376818177 6.9944883988895e-31 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.266371206927854 4.016968187035e-11 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199b-5p VEGFA -1.08432682485992 7.68241801134089e-10 0.873514320132464 2.52351953389146e-08 miRanda -0.107087744674295 0.00559641745284255 NA NA NA hsa-miR-29a-3p VEGFA -1.26881270980079 2.82496991513463e-22 0.873514320132464 2.52351953389146e-08 MirTarget -0.288406509783812 9.95429090012523e-09 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29c-3p VEGFA -2.08166260448948 8.3238369390898e-24 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;MirTarget -0.194088476141854 6.98364039221839e-10 NA NA NA hsa-miR-374a-5p VEGFA -0.621903385111545 6.61791773205282e-12 0.873514320132464 2.52351953389146e-08 MirTarget -0.350545644085801 3.16629895028707e-06 23679262 Our data demonstrated miR-374a to be differentially distributed in breast cancer; VEGF-A and VCAM-1 mRNA had coincident distribution and the distribution of teh respective proteins was uneven and opposite to that for the miR-374a breast cancer hsa-miR-378a-3p VEGFA -1.50453783521372 9.41694954361173e-17 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase -0.103722847977571 0.00515698881281656 NA NA NA hsa-miR-128-3p VEGFC -0.170677254601174 0.20412808476528 1.21496433527706 2.56999707057218e-05 miRNAWalker2_validate;MirTarget -0.344606861179054 0.000264644189549296 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-129-5p VEGFC -0.246329588499478 0.436451191224681 1.21496433527706 2.56999707057218e-05 miRanda -0.181674391970532 6.89957949062694e-06 NA NA NA hsa-miR-16-2-3p VEGFC 1.1567130855258 1.01867256952189e-14 1.21496433527706 2.56999707057218e-05 MirTarget -0.264631968748485 0.00136032612419468 NA NA NA hsa-miR-27b-3p VEGFC -0.732682718863563 2.26896143573324e-09 1.21496433527706 2.56999707057218e-05 MirTarget -1.03529262957351 2.14560495828989e-26 23593282 We identified vascular endothelial growth factor C VEGFC as a novel target gene of miR-27b and determined that miR-27b functioned as an inhibitor of tumor progression and angiogenesis through targeting VEGFC in CRC; In summary an anti-tumor role for miR-27b and its novel target VEGFC in vivo could lead to tumor necrosis and provide a rationale for developing miR-27b as a therapeutic agent progression colorectal cancer hsa-miR-374a-5p VEGFC -0.621903385111545 6.61791773205282e-12 1.21496433527706 2.56999707057218e-05 MirTarget -0.421266396238901 0.00236790056229042 NA NA NA hsa-miR-138-5p VIM 0.702468796115049 0.0082478986123581 0.293373039189948 0.0929079985573139 miRNAWalker2_validate -0.108580800349778 0.000339878064628274 26796277;27049260 miR-138 overexpression also down-regulated vimentin expression and upregulated E-cadherin expression suggesting that miR-138 inhibited EMT;In addition the epithelial-mesenchymal transition EMT related markers E-cadherin or vimentin was up-regulated or down-regulated upon the overexpression of miR-138 in NSCLC cells ; breast cancer;lung squamous cell cancer hsa-miR-16-5p VIM 0.521122945828175 1.40561786410572e-06 0.293373039189948 0.0929079985573139 miRNAWalker2_validate -0.238283139754788 0.000681868886911321 NA NA NA hsa-miR-17-3p VIM -0.0127974722290336 0.909559935689875 0.293373039189948 0.0929079985573139 miRNAWalker2_validate;miRNATAP -0.348346955536559 2.43266659976936e-07 19771525;23418359 The lack of miR-17-3p expression correlated with an increase in vimentin synthesis and tumorigenicity; Stable expression of miR-17-3p in the M12 subline reduced vimentin levels 85% and reverted growth to organized polarized acini in lrECM gels;In contrast the passenger strand miR-17-3p repressed expression of vimentin an intermediate filament with the ability to modulate metabolism and GalNT7 an enzyme that regulates metabolism of liver toxin galactosamine ; prostate cancer;liver cancer hsa-miR-26b-5p VIM -0.254478038884324 0.0285227763044636 0.293373039189948 0.0929079985573139 miRNAWalker2_validate -0.175046760441541 0.00784342940016753 24890815 Increased expression of miR-26b inhibited the migration and invasiveness of HCC cell lines which was accompanied by decreased expression of the epithelial marker E-cadherin and increased expression of the mesenchymal marker vimentin at both the mRNA and protein expression levels liver cancer hsa-miR-30c-5p VIM 0.021222006155897 0.886366656528128 0.293373039189948 0.0929079985573139 miRNAWalker2_validate;miRNATAP -0.199639645584282 9.78044350864617e-05 NA NA NA hsa-miR-30d-5p VIM -0.38399848121878 0.000171129616944749 0.293373039189948 0.0929079985573139 miRNATAP -0.291599807245164 8.98348525861816e-05 NA NA NA hsa-miR-320b VIM 1.23473838180754 3.04337566045537e-14 0.293373039189948 0.0929079985573139 PITA;miRanda;miRNATAP -0.144428422138454 0.0015470967734335 NA NA NA hsa-miR-590-5p VIM 0.763025362395968 3.65305892505623e-09 0.293373039189948 0.0929079985573139 PITA;miRanda;miRNATAP -0.337845029105898 4.05710938972995e-09 NA NA NA hsa-miR-708-3p VIM 1.32647174389322 4.87465491977979e-16 0.293373039189948 0.0929079985573139 MirTarget;miRNATAP -0.133897504225198 0.00306370007234284 NA NA NA hsa-miR-9-5p VIM 1.65694862043766 2.08325802567323e-05 0.293373039189948 0.0929079985573139 miRNAWalker2_validate -0.11115433340177 6.02677487506214e-09 25086633 Expression of miR-9 was also higher in tumors showing the CD44+/CD24- phenotype vimentin expression and E-cadherin loss breast cancer hsa-miR-141-3p WIPF1 0.730011517758706 0.000120338355004032 0.628217767041437 0.000174007614178323 MirTarget;TargetScan;miRNATAP -0.356311350194117 4.42872948073976e-22 NA NA NA hsa-miR-15a-5p WIPF1 0.783550182002274 2.60699595655907e-11 0.628217767041437 0.000174007614178323 miRNAWalker2_validate -0.164234492345036 0.00760132181779843 NA NA NA hsa-miR-182-5p WIPF1 1.15060905311096 6.25565852529946e-10 0.628217767041437 0.000174007614178323 MirTarget;miRNATAP -0.197133616440725 2.86439907208198e-07 NA NA NA hsa-miR-200a-3p WIPF1 0.607140814457753 0.00289840524858752 0.628217767041437 0.000174007614178323 MirTarget;miRNATAP -0.308941181765027 4.83317062857212e-19 NA NA NA hsa-miR-200b-3p WIPF1 0.0717138787925347 0.682858087587209 0.628217767041437 0.000174007614178323 MirTarget;TargetScan -0.338386805644992 8.42645193327148e-17 NA NA NA hsa-miR-200c-3p WIPF1 0.630251054099546 0.000131975031451555 0.628217767041437 0.000174007614178323 MirTarget;miRNATAP -0.269279873520447 6.79731455618514e-10 NA NA NA hsa-miR-205-3p WIPF1 1.2960640797621 5.80786479909147e-11 0.628217767041437 0.000174007614178323 MirTarget -0.18945852288624 1.41330641378158e-07 NA NA NA hsa-miR-224-5p WIPF1 1.94534596857416 1.88348779207332e-19 0.628217767041437 0.000174007614178323 mirMAP -0.184468368151413 1.18525710808966e-08 NA NA NA hsa-miR-30b-5p WIPF1 -0.400238605368173 0.00346540992719245 0.628217767041437 0.000174007614178323 MirTarget -0.259551519633085 1.05170415708769e-06 NA NA NA hsa-miR-30c-5p WIPF1 0.021222006155897 0.886366656528128 0.628217767041437 0.000174007614178323 MirTarget;miRNATAP -0.202672342623711 3.98754432089784e-05 NA NA NA hsa-miR-324-5p WIPF1 1.66709479707179 1.45961450445769e-23 0.628217767041437 0.000174007614178323 miRanda -0.193625507055564 3.62084170311118e-06 NA NA NA hsa-miR-338-3p WIPF1 -0.948755228846395 8.99167125682392e-08 0.628217767041437 0.000174007614178323 miRanda -0.215151173536671 1.03089993509937e-07 NA NA NA hsa-miR-33a-3p WIPF1 0.20371038027126 0.212335697664505 0.628217767041437 0.000174007614178323 MirTarget -0.191865456532238 2.3966064208037e-05 NA NA NA hsa-miR-361-5p WIPF1 0.0803683277369505 0.314043140368058 0.628217767041437 0.000174007614178323 miRanda -0.335772870704498 0.00031791594402073 NA NA NA hsa-miR-378a-5p WIPF1 -1.31095692407946 2.375328908085e-15 0.628217767041437 0.000174007614178323 MirTarget -0.121333122632527 0.00487639551137656 NA NA NA hsa-miR-429 WIPF1 0.559451508722375 0.00563641638673083 0.628217767041437 0.000174007614178323 MirTarget;PITA;miRanda;miRNATAP -0.3174492692791 9.87912550684987e-20 NA NA NA hsa-miR-582-3p WIPF1 -0.248056267546012 0.143798829508405 0.628217767041437 0.000174007614178323 PITA -0.156528568270994 0.000285896570640744 NA NA NA hsa-miR-624-5p WIPF1 -0.229389464626096 0.110488966509615 0.628217767041437 0.000174007614178323 MirTarget -0.205805057047827 5.65436132376441e-05 NA NA NA hsa-miR-96-5p WIPF1 1.42326703011157 4.39736150032373e-14 0.628217767041437 0.000174007614178323 miRNATAP -0.276826598878559 7.91539961741094e-14 NA NA NA hsa-let-7a-3p WNT5A 0.0966652362351867 0.423761916840503 0.230244489186426 0.276036125068596 miRNATAP -0.236393902681147 0.00203160512009966 NA NA NA hsa-miR-142-3p WNT5A 1.12754191614028 1.68798138028946e-08 0.230244489186426 0.276036125068596 miRanda -0.170207296882227 0.000170819602841971 NA NA NA hsa-miR-155-5p WNT5A 0.533437622040649 0.00248671179205372 0.230244489186426 0.276036125068596 miRNAWalker2_validate;mirMAP -0.292461135450501 1.33940668925285e-08 NA NA NA hsa-miR-15b-3p WNT5A 1.05020782493504 6.38723677324836e-14 0.230244489186426 0.276036125068596 mirMAP -0.175165295991482 0.00645298447676834 NA NA NA hsa-miR-16-2-3p WNT5A 1.1567130855258 1.01867256952189e-14 0.230244489186426 0.276036125068596 MirTarget;mirMAP -0.335972431523505 1.53488293667871e-08 NA NA NA hsa-miR-16-5p WNT5A 0.521122945828175 1.40561786410572e-06 0.230244489186426 0.276036125068596 miRNAWalker2_validate -0.370382454158463 1.19067012660461e-05 NA NA NA hsa-miR-186-5p WNT5A 0.353452958261612 0.000145058448579496 0.230244489186426 0.276036125068596 miRNAWalker2_validate;mirMAP;miRNATAP -0.450879801993129 5.17906690047651e-06 NA NA NA hsa-miR-205-3p WNT5A 1.2960640797621 5.80786479909147e-11 0.230244489186426 0.276036125068596 mirMAP -0.146584017158563 0.00129989170721468 NA NA NA hsa-miR-26b-5p WNT5A -0.254478038884324 0.0285227763044636 0.230244489186426 0.276036125068596 mirMAP;miRNATAP -0.280915259189257 0.00040737667148347 NA NA NA hsa-miR-29a-5p WNT5A 0.323252792625584 0.0370417231222825 0.230244489186426 0.276036125068596 mirMAP -0.260976602260308 1.01644561078111e-05 NA NA NA hsa-miR-30a-3p WNT5A -2.26144364746452 8.12421214153823e-31 0.230244489186426 0.276036125068596 mirMAP -0.118105642486288 0.00756898976025631 NA NA NA hsa-miR-30a-5p WNT5A -1.79779915425811 1.93360169837799e-26 0.230244489186426 0.276036125068596 miRNAWalker2_validate;mirMAP -0.17873480778717 0.000544504752065439 NA NA NA hsa-miR-30b-5p WNT5A -0.400238605368173 0.00346540992719245 0.230244489186426 0.276036125068596 mirMAP -0.382501092288541 8.72466565087115e-09 NA NA NA hsa-miR-30c-5p WNT5A 0.021222006155897 0.886366656528128 0.230244489186426 0.276036125068596 mirMAP -0.315278604382802 3.20061386526904e-07 NA NA NA hsa-miR-30d-3p WNT5A -0.577371911152798 2.02950840095287e-06 0.230244489186426 0.276036125068596 mirMAP -0.330966437618027 1.06807407622655e-05 NA NA NA hsa-miR-30e-3p WNT5A -0.890635378639789 1.65740480611339e-16 0.230244489186426 0.276036125068596 mirMAP -0.32558124534923 8.6493574536442e-05 NA NA NA hsa-miR-30e-5p WNT5A -1.02114836019762 6.81961221797866e-17 0.230244489186426 0.276036125068596 mirMAP -0.302477702909968 3.39614513198558e-05 NA NA NA hsa-miR-330-5p WNT5A 0.944693925383906 5.04972895657346e-13 0.230244489186426 0.276036125068596 miRanda -0.29230342849594 2.09572746719721e-05 NA NA NA hsa-miR-374b-5p WNT5A -0.288413933608091 0.0041474558664058 0.230244489186426 0.276036125068596 MirTarget;miRNATAP -0.304076813996518 0.000947733080358778 NA NA NA hsa-miR-576-5p WNT5A 0.940432050128373 6.90227595663302e-12 0.230244489186426 0.276036125068596 mirMAP -0.285474332440034 1.36168151290682e-05 NA NA NA hsa-miR-582-5p WNT5A -0.0366995972742474 0.821827119138923 0.230244489186426 0.276036125068596 miRNATAP -0.165827000654824 0.00340576037437022 NA NA NA hsa-miR-590-3p WNT5A 0.221436901462551 0.0965904764063157 0.230244489186426 0.276036125068596 miRanda;mirMAP;miRNATAP -0.250968399301464 0.000285345561598827 NA NA NA hsa-miR-7-1-3p WNT5A 1.13646121619622 1.49823237535933e-14 0.230244489186426 0.276036125068596 mirMAP -0.288658318926048 1.72502648080357e-06 NA NA NA hsa-miR-92a-3p WNT5A 0.994679542307232 1.32587679156217e-16 0.230244489186426 0.276036125068596 miRNAWalker2_validate -0.244964920046973 0.00100835732123874 NA NA NA