miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-106b-3p	BMI1	0.0129891760913399	0.902224220985325	0.317642163654291	0.000513144270188165	miRNAWalker2_validate	-0.130351311102409	1.16648423792387e-05		NA	NA	NA
hsa-miR-15a-5p	BMI1	0.812445324157528	4.50263417099822e-20	0.317642163654291	0.000513144270188165	miRNAWalker2_validate;miRTarBase	-0.106371353467624	0.0022559342681427	27596816	Our results suggest that overexpression of miR-15a and miR-16 mediates down-regulation of BMI1 and leads to mitochondrial mediated apoptosis		breast cancer
hsa-miR-218-5p	BMI1	-1.02621788318234	2.9221925445771e-23	0.317642163654291	0.000513144270188165	miRNAWalker2_validate;miRNATAP	-0.153596639831947	1.93660597616408e-07	25999024;24839010;23255074	Western blot analysis and luciferase reporter assay revealed that miR-218 decreased BMI1 expression by binding to the putative binding sites in its 3'-untranslated region 3'-UTR; The BMI1 mRNA expression levels were markedly increased and negatively correlated with the miR-218 expression level in the ESCC tissues; The knockdown of BMI1 by siRNA showed the same phenocopy as the effect of miR-218 on ESCC cells indicating that BMI1 was a major target of miR-218; In the present study our findings confirm miR-218 as a tumor suppressor and identify BMI1 as a novel target of miR-218 in ESCC;We then used the Dual-Luciferase assay system quantitative real-time RT-PCR qRT-PCR and Western blot analysis to determine that miR-218 targeted the 3'-UTR of the oncogenes CIP2A and BMI1 and thus regulated the biological process of melanoma; We further demonstrated that CIP2A and BMI1 knockdown phenocopies miR-218 overexpression; By targeting CIP2A and BMI1 miR-218 regulates the proliferation migration and invasion of the melanoma cell lines A375 and SK-MEL-2 indicating that miR-218 plays a pivotal role in melanoma development;Potential target genes of miR-218 were predicted and BMI1 polycomb ring finger oncogene BMI-1 a polycomb ring finger oncogene was identified as one of the potential targets	;;	esophageal cancer;melanoma;colon cancer
hsa-miR-27a-3p	BMI1	0.388496361379095	1.42373532086331e-05	0.317642163654291	0.000513144270188165	miRNAWalker2_validate	-0.214266920264547	7.59006741318292e-10		NA	NA	NA
hsa-miR-455-5p	BMI1	0.284641224662773	0.0357572339594277	0.317642163654291	0.000513144270188165	miRanda	-0.182962103826668	1.06459376538527e-15		NA	NA	NA