miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p CASP3 -0.0656092877172174 0.961124733677684 -0.00895575799140413 0.985101397582454 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.195644898270621 4.6747877969906e-14 hsa-let-7a-5p CASP8 -0.0656092877172174 0.961124733677684 -0.149211527811264 0.731733266717747 miRNAWalker2_validate -0.0686348615061303 0.0210384261733887 hsa-let-7c-5p BCL2L1 -0.143443180517618 0.886580802063121 0.150447773019176 0.810155517148199 miRNAWalker2_validate;miRTarBase -0.128294871675362 1.88688918547409e-19 20347499;20347499;20347499;20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines;Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA;Human hepatocellular carcinoma tissues with low expression of let-7c displayed higher expression of Bcl-xL protein than those with high expression of let-7c suggesting that low let-7 microRNA expression contributes to Bcl-xL over-expression;Finally expression of let-7c enhanced apoptosis of hepatoma cells upon exposure to sorafenib which downregulates expression of another anti-apoptotic Bcl-2 protein Mcl-1 let-7 microRNAs negatively regulate Bcl-xL expression in human hepatocellular carcinomas and induce apoptosis in cooperation with an anti-cancer drug targeting Mcl-1 ;;; liver cancer;liver cancer;liver cancer;liver cancer hsa-let-7g-5p BCL2L1 -0.168556367162896 0.835060549207039 0.150447773019176 0.810155517148199 miRNAWalker2_validate;miRTarBase;miRNATAP -0.126630887025706 3.82717679314587e-06 20347499;20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines;Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA ; liver cancer;liver cancer hsa-miR-101-3p CAPN2 -0.140525462772132 0.906382304639665 -0.0121103561755236 0.986646615645318 miRNAWalker2_validate;MirTarget -0.149003956616061 4.12361423682102e-05 hsa-miR-103a-3p BCL2 0.0952235048222612 0.939840715516335 -0.330211405493396 0.555031371665433 miRNAWalker2_validate -0.143991540481451 0.031272539693721 hsa-miR-103a-3p PRKAR2A 0.0952235048222612 0.939840715516335 -0.149339211195881 0.695378435991995 miRNAWalker2_validate -0.598146567510241 4.65664063552882e-27 hsa-miR-106b-5p CASP7 -0.0853499657102335 0.901700669947609 -0.119800196514739 0.803638561820115 miRNAWalker2_validate -0.110927422653021 1.26003328173106e-06 22986525;22986525 Moreover increased tumor miR-106b expression was associated with disease recurrence and the combination of high miR-106b and low CASP7 caspase-7 expressions in primary tumors was an independent predictor of early disease recurrence adjusted hazard ratio=4.1; 95% confidence interval: 1.6-12.3;Moreover selected phenotypes induced by miR-106b knockdown in DU145 human prostate cancer cells did not develop when both miR-106b and CASP7 expression were inhibited recurrence;; prostate cancer;prostate cancer hsa-miR-125b-5p AKT1 -0.0598851546678105 0.945288350565791 0.0626515976255728 0.927558384512439 miRNAWalker2_validate;miRTarBase -0.198341990959858 1.58124486218174e-28 hsa-miR-126-3p PIK3R2 -0.202653140756354 0.843324611648203 0.0188890891833005 0.974660326807292 miRNAWalker2_validate;miRTarBase -0.169496363080053 8.52458360518473e-17 21249429;21249429 Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2;In addition miR-126 could target both VEGFA and PIK3R2 and its expression was decreased in human breast cancer implying that miR-126 may play a role in tumor genesis and growth by regulating the VEGF/PI3K/AKT signaling pathway ; breast cancer;breast cancer hsa-miR-132-3p CASP7 0.0245028522614428 0.964849701708711 -0.119800196514739 0.803638561820115 miRNAWalker2_validate;MirTarget -0.107439780267955 0.000220260395052539 hsa-miR-136-5p BCL2 -0.320866067700925 0.456773210081763 -0.330211405493396 0.555031371665433 miRNAWalker2_validate;miRTarBase -0.134479560632769 0.000722378019814531 hsa-miR-143-3p AKT1 0.0939643084482285 0.945738813861442 0.0626515976255728 0.927558384512439 miRNAWalker2_validate -0.113351907486334 3.74647210660112e-08 hsa-miR-148a-3p BCL2 -0.184595009730559 0.892714155682155 -0.330211405493396 0.555031371665433 miRNAWalker2_validate;miRTarBase -0.220300574731754 3.43414567895446e-06 hsa-miR-149-5p BID 0.110896382194027 0.854013616827913 0.0152948145721421 0.97035763280396 miRNAWalker2_validate -0.0758457936683221 3.87492995175088e-08 hsa-miR-151a-3p IKBKB 0.0540261749026669 0.955985797011372 0.0975605327133957 0.86231928668593 miRNAWalker2_validate -0.109349947297392 0.0025250144404732 hsa-miR-155-5p PRKAR1A -0.167418736137707 0.822294484498835 0.0481949802694981 0.9487025470248 miRNAWalker2_validate -0.138059655346011 1.13999315375584e-15 hsa-miR-155-5p PRKAR2A -0.167418736137707 0.822294484498835 -0.149339211195881 0.695378435991995 miRNAWalker2_validate -0.172204491888852 8.04193305743878e-07 hsa-miR-15a-5p AKT3 0.027476192963463 0.965257307327948 -0.10604090651417 0.811944436836746 miRNAWalker2_validate;miRTarBase;miRNATAP -0.50537113863267 1.94212195956378e-21 hsa-miR-15a-5p BCL2 0.027476192963463 0.965257307327948 -0.330211405493396 0.555031371665433 miRNAWalker2_validate;miRTarBase -0.390139881240154 1.08000528360666e-09 22335947 The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 breast cancer hsa-miR-15a-5p CHUK 0.027476192963463 0.965257307327948 -0.00649042635415231 0.988335439566584 miRNAWalker2_validate;miRTarBase;MirTarget -0.135155500445723 3.1799004977298e-10 hsa-miR-15a-5p NFKB1 0.027476192963463 0.965257307327948 -0.182686900068147 0.740893021200228 miRNAWalker2_validate -0.0949701645954489 3.61409689091251e-05 hsa-miR-15b-5p BCL2 0.0382341477298391 0.953925647243518 -0.330211405493396 0.555031371665433 miRNAWalker2_validate;miRTarBase -0.282455107593279 9.40085716451768e-09 18449891;18449891;18449891 miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells;The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein;Enforced mir-15b or miR-16 expression reduced Bcl-2 protein level and the luciferase activity of a BCL2 3' untranslated region-based reporter construct in SGC7901/VCR cells suggesting that BCL2 is a direct target of miR-15b and miR-16 drug resistance;;; stomach cancer;stomach cancer;stomach cancer hsa-miR-16-5p AKT3 -0.131938295863899 0.869419037928521 -0.10604090651417 0.811944436836746 miRNAWalker2_validate;miRTarBase;miRNATAP -0.137142128931012 0.00593844300257035 hsa-miR-16-5p BCL2 -0.131938295863899 0.869419037928521 -0.330211405493396 0.555031371665433 miRNAWalker2_validate;miRTarBase -0.135959499751997 0.0214742298506771 hsa-miR-16-5p IRAK3 -0.131938295863899 0.869419037928521 -0.269594472929764 0.440968215803154 miRNAWalker2_validate -0.224494266578747 7.48648305027479e-05 hsa-miR-17-5p BCL2 -0.0085894792332244 0.990927211793889 -0.330211405493396 0.555031371665433 miRNAWalker2_validate;miRTarBase -0.416922204785524 7.52642290968327e-24 25435430;25435430;25435430 MiR-16 targets Bcl-2 in paclitaxel-resistant lung cancer cells and overexpression of miR-16 along with miR-17 causes unprecedented sensitivity by simultaneously modulating autophagy and apoptosis;Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively;miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 ;; lung cancer;lung cancer;lung cancer hsa-miR-17-5p XIAP -0.0085894792332244 0.990927211793889 -0.0212306078731803 0.970140712022331 miRNAWalker2_validate;TargetScan -0.133341945269304 6.31942971165112e-20 hsa-miR-181a-5p ATM 0.0637093750406734 0.945876131429707 -0.14578960482531 0.7778082923952 miRNAWalker2_validate;miRTarBase;MirTarget -0.212080382902989 6.50305312230929e-12 24531888 MicroRNA-181a functions as an oncomir in gastric cancer by targeting the tumour suppressor gene ATM stomach cancer hsa-miR-181a-5p BCL2 0.0637093750406734 0.945876131429707 -0.330211405493396 0.555031371665433 miRNAWalker2_validate;miRTarBase -0.399174853804926 9.83051271483704e-12 hsa-miR-181a-5p XIAP 0.0637093750406734 0.945876131429707 -0.0212306078731803 0.970140712022331 miRNAWalker2_validate;miRTarBase;mirMAP -0.158928439124698 8.20262640164062e-15 hsa-miR-181b-5p BCL2 0.0375130667115933 0.959555096276237 -0.330211405493396 0.555031371665433 miRNAWalker2_validate;miRTarBase -0.46875883187563 8.08303248718094e-22 hsa-miR-181b-5p XIAP 0.0375130667115933 0.959555096276237 -0.0212306078731803 0.970140712022331 miRNAWalker2_validate;miRTarBase;mirMAP -0.143863195368819 6.92537429724419e-17 hsa-miR-18a-5p ATM -0.060215066151506 0.836155187457355 -0.14578960482531 0.7778082923952 miRNAWalker2_validate;miRTarBase;MirTarget -0.116309277677122 3.16867464269194e-11 hsa-miR-192-5p BCL2 -0.13549863762303 0.859625790519489 -0.330211405493396 0.555031371665433 miRNAWalker2_validate -0.170899649695256 0.000266209546627792 24213572;24213572;25566965 Further studies indicate that miR-192 downregulates expression of Bcl-2 Zeb2 and VEGFA in vitro and in vivo which is responsible for enhanced apoptosis increased expression of E-cadherin and decreased angiogenesis in vivo respectively;Therefore a major implication of our studies is that restoration of miR-192 expression or antagonism of its target genes Bcl-2 Zeb2 or VEGFA may have considerable therapeutic potential for anti-metastatic therapy in patients with colon cancer;Moreover overexpression of miR-192 significantly induced apoptotic death in bladder cancer cells increased the levels of p21 p27 and Bax and decreased the levels of cyclin D1 Bcl-2 and Mcl-1 ;; colorectal cancer;colorectal cancer;bladder cancer hsa-miR-192-5p IL1R1 -0.13549863762303 0.859625790519489 -0.0897068964064003 0.872943387530182 miRNAWalker2_validate -0.29199087319334 3.85990473776844e-15 hsa-miR-193b-3p IRAK1 -0.258193381252116 0.674998055533564 0.00183544026223181 0.997658765903688 miRNAWalker2_validate -0.0559796960470978 0.0256371043304728 hsa-miR-195-5p CHUK -0.00971531160236339 0.98418421453416 -0.00649042635415231 0.988335439566584 miRNAWalker2_validate;MirTarget -0.0963705166449091 3.21782812275272e-09 hsa-miR-196b-5p BCL2 -0.339377433567605 0.635151980425286 -0.330211405493396 0.555031371665433 miRNAWalker2_validate -0.0839370995565701 0.0117856320882715 hsa-miR-19b-1-5p CASP8 -0.126966953724701 0.619571308879527 -0.149211527811264 0.731733266717747 miRNAWalker2_validate -0.0595582560168122 0.00104176615664021 hsa-miR-19b-3p PRKACB -0.0314903804749491 0.95913844863355 -0.0742837105484302 0.886731753016865 miRNAWalker2_validate;MirTarget;miRNATAP -0.13474256019019 0.00164169207970928 hsa-miR-200c-3p BCL2 -0.0449560636499466 0.969433069399071 -0.330211405493396 0.555031371665433 miRNAWalker2_validate;miRTarBase;mirMAP -0.0867274578438017 0.0285945952451784 hsa-miR-20a-5p BCL2 0.0648697217907399 0.924634007033878 -0.330211405493396 0.555031371665433 miRNAWalker2_validate;miRTarBase -0.398529315160521 3.65662136244948e-20 hsa-miR-21-5p APAF1 0.0148493782366828 0.992419670576308 -0.0751479999846154 0.860066851482364 miRNAWalker2_validate;miRTarBase -0.0953345867229539 3.37912422023423e-06 hsa-miR-21-5p BCL2 0.0148493782366828 0.992419670576308 -0.330211405493396 0.555031371665433 miRNAWalker2_validate;miRTarBase -0.486116466611641 4.94993012898121e-21 hsa-miR-21-5p FAS 0.0148493782366828 0.992419670576308 -0.0598268469538907 0.867543041079802 miRNAWalker2_validate -0.0737045561744755 0.0311451571635879 hsa-miR-21-5p NFKB1 0.0148493782366828 0.992419670576308 -0.182686900068147 0.740893021200228 miRNAWalker2_validate -0.0743612934237505 7.98207139465469e-05 hsa-miR-21-5p PIK3R1 0.0148493782366828 0.992419670576308 -0.161573746542345 0.805057044088694 miRNAWalker2_validate;MirTarget;miRNATAP -0.442813578327247 2.68375696066295e-30 hsa-miR-223-3p CHUK -0.25971106178338 0.669659245147467 -0.00649042635415231 0.988335439566584 miRNAWalker2_validate;miRTarBase -0.0621433011665751 5.0490737462076e-06 hsa-miR-23b-3p BCL2L1 -0.158093770583088 0.851138252196472 0.150447773019176 0.810155517148199 miRNAWalker2_validate -0.0917069821613541 9.01213339836235e-06 hsa-miR-24-2-5p BCL2 -0.21947891044926 0.609451080102927 -0.330211405493396 0.555031371665433 miRNAWalker2_validate;miRTarBase -0.314657429269267 1.22690370959234e-10 hsa-miR-25-3p PRKAR1A 0.0550592306329012 0.962829613775088 0.0481949802694981 0.9487025470248 miRNAWalker2_validate -0.164526077689284 3.07364432032994e-07 hsa-miR-26b-5p CASP3 -0.165683456923659 0.842739329770527 -0.00895575799140413 0.985101397582454 miRNAWalker2_validate -0.0506536472085388 0.017846620199039 hsa-miR-29c-3p AKT3 -0.0526710652467877 0.956320854458284 -0.10604090651417 0.811944436836746 miRNAWalker2_validate;miRNATAP -0.188130633733952 1.47230271027192e-05 hsa-miR-30a-5p PPP3R1 -0.315304933842571 0.81611555406281 -0.0271826487262787 0.962679518571233 miRNAWalker2_validate;MirTarget;miRNATAP -0.13382780475557 1.01801426792285e-27 hsa-miR-30c-5p AIFM1 -0.268052278300344 0.753220585849573 0.125157247739673 0.810026159590102 miRNAWalker2_validate -0.0544410070913514 0.0174129254226485 hsa-miR-30c-5p PIK3R2 -0.268052278300344 0.753220585849573 0.0188890891833005 0.974660326807292 miRNAWalker2_validate;miRNATAP -0.102854891876324 0.000118472431445014 hsa-miR-30d-5p CASP3 0.00512174341017158 0.996390931509314 -0.00895575799140413 0.985101397582454 miRNAWalker2_validate;miRTarBase;miRNATAP -0.0771337062674256 0.0012482922569362 hsa-miR-330-5p BAD -0.0582594636115701 0.896794748650637 0.125645252917708 0.78981599240697 miRNAWalker2_validate;miRanda -0.0868219301333439 0.00429945532173617 hsa-miR-34a-5p BCL2 -0.00150684423480296 0.998107346259152 -0.330211405493396 0.555031371665433 miRNAWalker2_validate;miRTarBase -0.21690891602483 0.00143015924808101 22623155;22623155;24565525;21399894;21399894 MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1;Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;Modulation of miR-34a expression was correlated with BCL-2 and cyclin D1 protein expression changes and a direct interaction of miR-34a with BCL-2 was shown by luciferase assay ;;drug resistance;;; breast cancer;breast cancer;breast cancer;breast cancer;breast cancer hsa-miR-365a-3p BAX 0.0307303320006067 0.959616484776468 0.22864526220017 0.60760941519503 miRNAWalker2_validate -0.197311099125654 4.24250463560438e-13 hsa-miR-375 BIRC3 0.324254910768071 0.784908661939924 -0.351018966497297 0.384034819284766 miRNAWalker2_validate -0.126687363073563 5.66067780629141e-10 23726271 Taken together these data suggest that miR-375 sensitizes TNF-α-induced apoptosis and the reduction in the expression of the apoptosis inhibitory proteins cFLIP-L and cIAP2 plays an important role in this sensitization head and neck squamous cell cancer hsa-miR-375 IL1RAP 0.324254910768071 0.784908661939924 -0.142375836605543 0.647003549805492 miRNAWalker2_validate;miRanda -0.111918762451102 1.90407427894537e-13 hsa-miR-375 PRKX 0.324254910768071 0.784908661939924 -0.16691261365817 0.713645814762555 miRNAWalker2_validate;miRanda -0.207392873270567 7.07421795114455e-35 hsa-miR-429 BCL2 -0.142589289838583 0.802317907773415 -0.330211405493396 0.555031371665433 miRNAWalker2_validate;miRTarBase;PITA;mirMAP -0.121974754205047 0.000143492269579093 hsa-miR-491-5p BCL2L1 -0.423577120749209 0.0220584227099558 0.150447773019176 0.810155517148199 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda -0.0811993813408957 1.92020105109379e-07 25299770;25299770;23519249;20039318 We found that miR-491-5p efficiently induces apoptosis in IGROV1-R10 cells by directly inhibiting BCL-XL expression and by inducing BIM accumulation in its dephosphorylated form;In contrast SKOV3 cells treated with miR-491-5p maintain AKT and MAPK activity do not induce BIM and do not undergo cell death despite BCL-XL and EGFR downregulation;Overexpression of miR-491-5p in the pancreatic cancer cell line SW1990 effectively inhibited both endogenous Bcl-XL and TP53 gene expressions;We demonstrated that Bcl-XL was a direct target of miR-491 and its silencing contributed to miR-491-induced apoptosis ;;; ovarian cancer;ovarian cancer;pancreatic cancer;colorectal cancer hsa-miR-590-3p PRKAR2B -0.133358268237272 0.535686159072243 -0.0554605800632748 0.917605527457847 miRNAWalker2_validate;miRanda -0.304016287373841 5.72972948135857e-11 hsa-miR-708-5p AKT2 -0.180929524949216 0.695247413572264 0.0504008323501575 0.936738544702785 miRNAWalker2_validate;miRTarBase -0.0599082989701229 0.000205194776922093 22552290 Together our findings suggest that reduced miR-708 expression leads to prostate cancer initiation progression and development by regulating the expression of CD44 as well as AKT2 miR-708 therefore may represent a novel therapeutic target or diagnostic and prognostic biomarker in prostate cancer progression; prostate cancer hsa-miR-93-5p PRKACB 0.0554251653547535 0.959380932710413 -0.0742837105484302 0.886731753016865 miRNAWalker2_validate -0.337877597223658 9.95580809015501e-13 hsa-miR-96-5p BCL2 -0.153312892459014 0.726115467443483 -0.330211405493396 0.555031371665433 miRNAWalker2_validate;TargetScan -0.0701208876755479 0.0368215344791791 hsa-miR-96-5p PRKAR1A -0.153312892459014 0.726115467443483 0.0481949802694981 0.9487025470248 miRNAWalker2_validate;TargetScan;miRNATAP -0.0683751398288542 1.79879121781643e-06 hsa-miR-98-5p FAS 0.0782917740368987 0.880173437070493 -0.0598268469538907 0.867543041079802 miRNAWalker2_validate -0.147800482737569 0.000760862411963529 hsa-miR-98-5p TNFSF10 0.0782917740368987 0.880173437070493 -0.197812618297202 0.765914684971228 miRNAWalker2_validate -0.371869472099461 1.42448937706376e-11 hsa-let-7b-3p AKT2 -0.287127027685606 0.565601265486799 0.0504008323501575 0.936738544702785 MirTarget -0.0782735853987187 7.64575681469218e-06 hsa-let-7b-5p CASP3 -0.199052001138817 0.878277241542979 -0.00895575799140413 0.985101397582454 MirTarget;miRNATAP -0.135377392684109 1.39837315047849e-11 hsa-let-7c-5p CASP3 -0.143443180517618 0.886580802063121 -0.00895575799140413 0.985101397582454 MirTarget -0.131994349405243 7.44021418353714e-21 hsa-let-7d-5p NGF -0.176960380407253 0.795858406343421 0.0421653122976033 0.823871342075226 MirTarget -0.171326999284145 0.00225973911147285 hsa-let-7f-1-3p AKT2 -0.222769653030984 0.176243975299018 0.0504008323501575 0.936738544702785 MirTarget -0.0603655617668234 0.000921839647061436 hsa-let-7g-5p NGF -0.168556367162896 0.835060549207039 0.0421653122976033 0.823871342075226 MirTarget -0.147813638501184 0.0299040099952209 hsa-miR-101-3p RIPK1 -0.140525462772132 0.906382304639665 -0.00624459434673863 0.990346024302325 MirTarget -0.057432949065505 0.000570825909895574 hsa-miR-101-3p CASP3 -0.140525462772132 0.906382304639665 -0.00895575799140413 0.985101397582454 MirTarget -0.205647208491522 1.01890278591706e-18 hsa-miR-103a-3p PIK3R1 0.0952235048222612 0.939840715516335 -0.161573746542345 0.805057044088694 MirTarget;miRNATAP -0.516011898515825 9.39970675304441e-26 hsa-miR-106a-5p PIK3R1 -0.142040012764908 0.692192967482747 -0.161573746542345 0.805057044088694 MirTarget;miRNATAP -0.0607306237538122 0.0371115164699839 hsa-miR-106b-5p PIK3R1 -0.0853499657102335 0.901700669947609 -0.161573746542345 0.805057044088694 MirTarget;miRNATAP -0.458684807618424 6.41212047089543e-31 hsa-miR-106b-5p IL1RAP -0.0853499657102335 0.901700669947609 -0.142375836605543 0.647003549805492 MirTarget -0.21747394048456 4.55727177522678e-09 hsa-miR-106b-5p CASP8 -0.0853499657102335 0.901700669947609 -0.149211527811264 0.731733266717747 MirTarget -0.0531213915639962 0.0137422317412954 hsa-miR-107 PIK3R1 -0.00374429919903285 0.994322461958742 -0.161573746542345 0.805057044088694 MirTarget;PITA;miRanda;miRNATAP -0.564782368968385 1.29413413077175e-28 hsa-miR-125a-5p PIK3R5 0.00741438556537055 0.993308396064258 -0.104173592703419 0.722260081244307 MirTarget;miRanda -0.280593880513026 8.91996620676494e-14 hsa-miR-128-3p PIK3R1 -0.0716382541209697 0.906783499707385 -0.161573746542345 0.805057044088694 MirTarget -0.464882086210543 2.18929508374026e-24 hsa-miR-1301-3p PIK3R1 -0.0935647712087007 0.781492825390485 -0.161573746542345 0.805057044088694 MirTarget -0.312737279865189 3.51588268231222e-28 hsa-miR-130b-3p ENDOD1 -0.211426879967744 0.486104856445712 0.0942615531150564 0.862445027709995 MirTarget -0.0722873777013853 0.0051593791245414 hsa-miR-132-3p PIK3R1 0.0245028522614428 0.964849701708711 -0.161573746542345 0.805057044088694 MirTarget -0.121882557287893 0.0194776509799562 hsa-miR-141-3p PRKACB -0.179420502124191 0.83354105481228 -0.0742837105484302 0.886731753016865 MirTarget;TargetScan;miRNATAP -0.14986275424127 3.7367241254854e-07 hsa-miR-143-5p NFKBIA -0.291325446322919 0.584981815156526 -0.00261794720769437 0.996644658089948 MirTarget -0.0556130344779614 7.44461770301843e-05 hsa-miR-155-5p XIAP -0.167418736137707 0.822294484498835 -0.0212306078731803 0.970140712022331 MirTarget -0.0988563063116057 2.9020041777769e-12 hsa-miR-15a-5p PIK3R1 0.027476192963463 0.965257307327948 -0.161573746542345 0.805057044088694 MirTarget -0.467053807879393 1.27196995879228e-22 hsa-miR-15b-5p PIK3R1 0.0382341477298391 0.953925647243518 -0.161573746542345 0.805057044088694 MirTarget -0.304923263873542 1.52536411684308e-16 hsa-miR-16-2-3p PIK3R1 -0.107555719075227 0.702302679752719 -0.161573746542345 0.805057044088694 MirTarget -0.187390623272605 5.18756959426033e-08 hsa-miR-16-5p PIK3R1 -0.131938295863899 0.869419037928521 -0.161573746542345 0.805057044088694 MirTarget -0.185144677288316 3.4393027748885e-05 hsa-miR-17-3p PPP3CA -0.00462206849027691 0.994608252674318 -0.078895894384611 0.886413963353503 MirTarget -0.124078923715287 5.08318296663462e-06 hsa-miR-17-5p PIK3R1 -0.0085894792332244 0.990927211793889 -0.161573746542345 0.805057044088694 MirTarget;TargetScan;miRNATAP -0.305623214527227 2.73465966965389e-22 hsa-miR-17-5p CASP8 -0.0085894792332244 0.990927211793889 -0.149211527811264 0.731733266717747 MirTarget -0.0729947325983932 1.47416867360356e-05 hsa-miR-181a-5p PPP3R1 0.0637093750406734 0.945876131429707 -0.0271826487262787 0.962679518571233 MirTarget;miRNATAP -0.066533655540662 0.000665578435861528 hsa-miR-181a-5p PIK3R3 0.0637093750406734 0.945876131429707 -0.219842654525774 0.727127805779104 MirTarget;miRNATAP -0.146056981056209 1.20649375988888e-05 hsa-miR-181a-5p ENDOD1 0.0637093750406734 0.945876131429707 0.0942615531150564 0.862445027709995 MirTarget -0.189683107950902 4.37281846681927e-08 hsa-miR-181b-5p ATM 0.0375130667115933 0.959555096276237 -0.14578960482531 0.7778082923952 MirTarget -0.217803705013907 3.99505534670018e-17 hsa-miR-181b-5p PIK3R3 0.0375130667115933 0.959555096276237 -0.219842654525774 0.727127805779104 MirTarget;miRNATAP -0.066834912488698 0.0181430913395701 hsa-miR-181b-5p ENDOD1 0.0375130667115933 0.959555096276237 0.0942615531150564 0.862445027709995 MirTarget -0.180407157525064 6.27867737417705e-10 hsa-miR-181c-5p ATM -0.18121298802215 0.718350072627076 -0.14578960482531 0.7778082923952 MirTarget -0.0890833743472474 0.00087645664577415 hsa-miR-181c-5p PPP3R1 -0.18121298802215 0.718350072627076 -0.0271826487262787 0.962679518571233 MirTarget;miRNATAP -0.125950184238424 2.66954355100233e-14 hsa-miR-181c-5p CSF2RB -0.18121298802215 0.718350072627076 -0.16285175934955 0.64748767357227 MirTarget -0.117493887020018 0.00393145815724916 hsa-miR-181c-5p PIK3R3 -0.18121298802215 0.718350072627076 -0.219842654525774 0.727127805779104 MirTarget;miRNATAP -0.0897489023493697 0.00177105197609106 hsa-miR-181d-5p ATM -0.116844052208921 0.774221578291478 -0.14578960482531 0.7778082923952 MirTarget -0.119716083515509 3.28179905476897e-07 hsa-miR-181d-5p PPP3R1 -0.116844052208921 0.774221578291478 -0.0271826487262787 0.962679518571233 MirTarget -0.0932828411439749 1.78868200053676e-10 hsa-miR-181d-5p CSF2RB -0.116844052208921 0.774221578291478 -0.16285175934955 0.64748767357227 MirTarget -0.175286399953369 8.92491566553761e-07 hsa-miR-181d-5p PIK3R3 -0.116844052208921 0.774221578291478 -0.219842654525774 0.727127805779104 MirTarget -0.0614974123398033 0.0149891156449479 hsa-miR-181d-5p ENDOD1 -0.116844052208921 0.774221578291478 0.0942615531150564 0.862445027709995 MirTarget -0.0653322222641992 0.0130730847177395 hsa-miR-182-5p PIK3R5 -0.101509746042318 0.939206381321837 -0.104173592703419 0.722260081244307 MirTarget -0.108305079676846 2.32094065834864e-05 hsa-miR-185-3p MAP3K14 -0.0609325092037492 0.780830371804221 -0.12414810023034 0.758808723687369 MirTarget -0.0838160379660288 3.987275644149e-05 hsa-miR-194-5p PPP3CA -0.0985657553098873 0.88041455080541 -0.078895894384611 0.886413963353503 MirTarget -0.132376274530416 0.000303144003211118 hsa-miR-195-3p CASP3 -0.0314657373015459 0.893921960533907 -0.00895575799140413 0.985101397582454 MirTarget -0.161373451028419 9.65654022351954e-22 hsa-miR-19a-3p PRKACB -0.00951638786771092 0.980991306004163 -0.0742837105484302 0.886731753016865 MirTarget;miRNATAP -0.144307019920445 3.41593280940585e-05 hsa-miR-19a-3p CASP10 -0.00951638786771092 0.980991306004163 0.137538027972401 0.674204872280143 MirTarget;mirMAP -0.123492546324159 2.38250886062143e-06 hsa-miR-19a-3p PIK3R3 -0.00951638786771092 0.980991306004163 -0.219842654525774 0.727127805779104 MirTarget;miRNATAP -0.0691253156572027 0.00162140589208115 hsa-miR-19b-1-5p XIAP -0.126966953724701 0.619571308879527 -0.0212306078731803 0.970140712022331 MirTarget -0.13308977349311 2.8869452185803e-17 hsa-miR-19b-3p CASP10 -0.0314903804749491 0.95913844863355 0.137538027972401 0.674204872280143 MirTarget;mirMAP -0.129061129824549 5.98267977322353e-05 hsa-miR-19b-3p CSF2RB -0.0314903804749491 0.95913844863355 -0.16285175934955 0.64748767357227 MirTarget -0.0823133837136632 0.0312293453348678 hsa-miR-19b-3p PIK3R3 -0.0314903804749491 0.95913844863355 -0.219842654525774 0.727127805779104 MirTarget;miRNATAP -0.109224067759979 4.71454242795867e-05 hsa-miR-19b-3p CASP8 -0.0314903804749491 0.95913844863355 -0.149211527811264 0.731733266717747 MirTarget -0.0696165834516058 0.000229213801798591 hsa-miR-200a-3p PRKACB -0.192839143060886 0.77994979695622 -0.0742837105484302 0.886731753016865 MirTarget;miRNATAP -0.0995415556173883 0.000611951485595998 hsa-miR-200b-3p PRKACB -0.109983892590611 0.891357972128093 -0.0742837105484302 0.886731753016865 MirTarget;TargetScan -0.128358992363134 6.97422500356901e-05 hsa-miR-200c-3p EXOG -0.0449560636499466 0.969433069399071 -0.100426110949723 0.669096652484011 MirTarget -0.0786500000270705 7.68448774918358e-09 hsa-miR-200c-3p PRKACB -0.0449560636499466 0.969433069399071 -0.0742837105484302 0.886731753016865 MirTarget;miRNATAP -0.165596646495394 2.94921644943646e-06 hsa-miR-203a-3p ATM -0.0587428946483168 0.955500869059044 -0.14578960482531 0.7778082923952 MirTarget -0.0697980223629827 2.17175122490629e-07 hsa-miR-20a-5p PIK3R1 0.0648697217907399 0.924634007033878 -0.161573746542345 0.805057044088694 MirTarget;miRNATAP -0.329404805146422 7.47770247059783e-24 hsa-miR-20a-5p IL1RAP 0.0648697217907399 0.924634007033878 -0.142375836605543 0.647003549805492 MirTarget -0.071946795044328 0.0185627590376071 hsa-miR-20a-5p CASP8 0.0648697217907399 0.924634007033878 -0.149211527811264 0.731733266717747 MirTarget -0.120887766356647 3.653106895295e-12 hsa-miR-20b-5p IL1RAP -0.275771697228234 0.506979861341138 -0.142375836605543 0.647003549805492 MirTarget -0.0671596963942077 0.000784045420490977 hsa-miR-212-3p PIK3R1 0.0651691163056072 0.740903353495934 -0.161573746542345 0.805057044088694 MirTarget -0.0864488468920506 0.0148411343512392 hsa-miR-212-3p CASP7 0.0651691163056072 0.740903353495934 -0.119800196514739 0.803638561820115 MirTarget -0.0549959915109557 0.0055177895079809 hsa-miR-214-5p TRAF2 -0.143468551850718 0.734457173217684 0.0847241975044639 0.840872248383899 MirTarget -0.0964617306633593 0.000325503030395416 hsa-miR-221-3p PIK3R1 -0.0578227721969284 0.924067621219326 -0.161573746542345 0.805057044088694 MirTarget -0.0865734061460642 0.0169391535797724 hsa-miR-25-3p PIK3R3 0.0550592306329012 0.962829613775088 -0.219842654525774 0.727127805779104 MirTarget -0.129911102729152 0.00226643466666436 hsa-miR-26a-5p PPP3R1 -0.0558466394626773 0.953979749143751 -0.0271826487262787 0.962679518571233 MirTarget;miRNATAP -0.15120972679612 1.94023722332139e-09 hsa-miR-29a-3p AKT2 -0.173904473376583 0.873886834369773 0.0504008323501575 0.936738544702785 MirTarget -0.0560826958509725 0.0124388723328744 hsa-miR-29b-3p PIK3R1 -0.147629200668355 0.855068431567557 -0.161573746542345 0.805057044088694 MirTarget;miRNATAP -0.212535407562809 1.00431864575306e-07 hsa-miR-29b-3p IL1RAP -0.147629200668355 0.855068431567557 -0.142375836605543 0.647003549805492 MirTarget;miRNATAP -0.163903329531063 6.4615367353943e-06 hsa-miR-29b-3p TNFRSF1A -0.147629200668355 0.855068431567557 0.0501674719580505 0.935452447515846 MirTarget;miRNATAP -0.0734254958633478 8.8650975674661e-06 hsa-miR-29c-3p IL1RAP -0.0526710652467877 0.956320854458284 -0.142375836605543 0.647003549805492 MirTarget;miRNATAP -0.286804830052282 2.35500785921953e-16 hsa-miR-29c-3p TNFRSF1A -0.0526710652467877 0.956320854458284 0.0501674719580505 0.935452447515846 MirTarget;miRNATAP -0.0594305246491478 0.000233771212663847 hsa-miR-29c-3p BIRC2 -0.0526710652467877 0.956320854458284 -0.054097022366637 0.920994914032685 MirTarget -0.121096414722903 1.04617957302389e-11 hsa-miR-301a-3p IL1RAP -0.0522829902990942 0.861546852981366 -0.142375836605543 0.647003549805492 MirTarget -0.0538595211402722 0.0238162605606334 hsa-miR-30b-3p PIK3CD -0.0548896605999709 0.756378945374427 -0.147433448424908 0.694309739932742 MirTarget -0.12656414985523 3.07110294580941e-05 24293274 MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS PIK3CD and BCL2 colorectal cancer hsa-miR-30b-3p CASP10 -0.0548896605999709 0.756378945374427 0.137538027972401 0.674204872280143 MirTarget -0.114632426890432 0.000219596665102797 hsa-miR-30b-3p CSF2RB -0.0548896605999709 0.756378945374427 -0.16285175934955 0.64748767357227 MirTarget -0.171488311438998 2.87804505829104e-06 hsa-miR-30b-5p PIK3CD -0.126278303055191 0.871574517121767 -0.147433448424908 0.694309739932742 MirTarget -0.098156140178123 0.00491657760209172 24293274 MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS PIK3CD and BCL2 colorectal cancer hsa-miR-30c-5p PIK3CD -0.268052278300344 0.753220585849573 -0.147433448424908 0.694309739932742 MirTarget;miRNATAP -0.0811329432098842 0.0361761528541293 hsa-miR-320a CASP3 0.0425274543382255 0.958191670788918 -0.00895575799140413 0.985101397582454 MirTarget;miRanda -0.0768284383852755 0.000729023371809975 hsa-miR-320a FADD 0.0425274543382255 0.958191670788918 0.0857513186223438 0.854367424974715 MirTarget;miRanda -0.0757803965571421 0.0315524176987645 hsa-miR-324-3p PIK3R1 -0.0533960575545418 0.892365633037602 -0.161573746542345 0.805057044088694 MirTarget;PITA;miRNATAP -0.224592588456891 6.81384539720142e-09 hsa-miR-330-3p PIK3R1 -0.00366157141494194 0.98416704678615 -0.161573746542345 0.805057044088694 MirTarget;PITA;miRNATAP -0.144041669892523 7.57903802651215e-05 hsa-miR-331-3p MAP3K14 -0.235461895487326 0.594749794653888 -0.12414810023034 0.758808723687369 MirTarget -0.148338380185048 1.0581376256797e-13 hsa-miR-340-5p PPP3CB 0.0820090452273905 0.816484190854532 0.0212980346837259 0.969289216388387 MirTarget -0.156446625862705 8.32036945224755e-19 hsa-miR-345-5p MAP3K14 -0.318796500689201 0.40673094545688 -0.12414810023034 0.758808723687369 MirTarget -0.119214954004009 1.4484437317052e-12 hsa-miR-361-3p PPP3CA -0.0127254134873924 0.984476698818773 -0.078895894384611 0.886413963353503 MirTarget;PITA;miRNATAP -0.0983817923500186 0.0225060073653217 hsa-miR-361-5p PIK3R1 0.0775639231585332 0.909963521897996 -0.161573746542345 0.805057044088694 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.278078422988115 0.000207710985727821 hsa-miR-361-5p ENDOD1 0.0775639231585332 0.909963521897996 0.0942615531150564 0.862445027709995 MirTarget;miRanda -0.328469522766262 1.32367340539702e-08 hsa-miR-365a-3p DFFB 0.0307303320006067 0.959616484776468 -0.0139931772031483 0.954936566867076 MirTarget -0.123337323732796 1.3394208762177e-12 hsa-miR-365a-3p MYD88 0.0307303320006067 0.959616484776468 -0.11843149058201 0.829539184991934 MirTarget -0.0637229677585112 0.000136696647937282 hsa-miR-376c-3p CHUK -0.207862770329174 0.336782853961576 -0.00649042635415231 0.988335439566584 MirTarget -0.0613194774475136 2.84867991474522e-06 hsa-miR-423-5p PIK3R2 -0.0275038364546472 0.956931958131863 0.0188890891833005 0.974660326807292 MirTarget -0.095990629302966 0.00172317017811727 hsa-miR-429 PRKACB -0.142589289838583 0.802317907773415 -0.0742837105484302 0.886731753016865 MirTarget;PITA;miRanda;miRNATAP -0.0987523385236987 0.000620715443624304 hsa-miR-432-5p PIK3R3 -0.206817222859276 0.428192312627123 -0.219842654525774 0.727127805779104 MirTarget -0.0639970625314257 0.00638747316633384 hsa-miR-450b-5p PPP3CB 0.140781738083346 0.700777724167455 0.0212980346837259 0.969289216388387 MirTarget;PITA;miRNATAP -0.0741011799432195 7.74219820151297e-06 hsa-miR-450b-5p ENDOD1 0.140781738083346 0.700777724167455 0.0942615531150564 0.862445027709995 MirTarget;mirMAP -0.0961801318257564 0.000777194666110001 hsa-miR-452-5p XIAP -0.0590392811106577 0.906930362717493 -0.0212306078731803 0.970140712022331 MirTarget;mirMAP -0.0646375213865503 6.07673579307936e-12 hsa-miR-454-3p IL1RAP -0.0807547300787816 0.779337172929459 -0.142375836605543 0.647003549805492 MirTarget -0.105478734601112 0.000246650313553492 hsa-miR-454-3p ENDOD1 -0.0807547300787816 0.779337172929459 0.0942615531150564 0.862445027709995 MirTarget -0.07092573861692 0.00392701261210477 hsa-miR-455-3p PIK3R1 -0.332546859679539 0.617979023781481 -0.161573746542345 0.805057044088694 MirTarget;PITA;miRNATAP -0.0762406386445435 0.00104939055142122 hsa-miR-484 PIK3CD -0.167034215156431 0.771225151614856 -0.147433448424908 0.694309739932742 MirTarget;miRNATAP -0.141552727299567 4.96089022907138e-05 hsa-miR-532-3p TRAF2 -0.247223762437475 0.58134232021997 0.0847241975044639 0.840872248383899 MirTarget -0.0736331127760816 0.000997917205724239 hsa-miR-589-5p ENDOD1 -0.0214815940746442 0.967157138449855 0.0942615531150564 0.862445027709995 MirTarget -0.177152650581664 9.75777718401495e-06 hsa-miR-590-5p PIK3R1 -0.131787544750195 0.684613701486826 -0.161573746542345 0.805057044088694 MirTarget;PITA;miRanda;miRNATAP -0.209937562895491 3.68537681569131e-10 hsa-miR-629-3p PIK3R1 -0.203962319893151 0.416043359122368 -0.161573746542345 0.805057044088694 MirTarget -0.122961236064884 5.54567297669118e-06 hsa-miR-664a-3p CASP7 0.0260321839026805 0.956434140422838 -0.119800196514739 0.803638561820115 MirTarget -0.0534195544951445 0.0278888895840413 hsa-miR-671-5p NFKB1 0.0238736022615038 0.908889383230195 -0.182686900068147 0.740893021200228 MirTarget -0.0603703476496842 0.000112102294581236 hsa-miR-874-3p MAP3K14 -0.24265834187865 0.588271320498706 -0.12414810023034 0.758808723687369 MirTarget -0.132080548476967 7.02111806746594e-07 hsa-miR-92a-3p PIK3R3 -0.0230307937945682 0.984317735692711 -0.219842654525774 0.727127805779104 MirTarget;miRNATAP -0.227757876133252 1.19233380886192e-12 hsa-miR-93-5p PIK3R1 0.0554251653547535 0.959380932710413 -0.161573746542345 0.805057044088694 MirTarget;miRNATAP -0.499295395694502 3.97678732290002e-38 hsa-miR-93-5p IL1RAP 0.0554251653547535 0.959380932710413 -0.142375836605543 0.647003549805492 MirTarget -0.2257972040621 5.94448947863886e-10 hsa-miR-93-5p CASP8 0.0554251653547535 0.959380932710413 -0.149211527811264 0.731733266717747 MirTarget -0.0956679676373077 5.95839158509584e-06 hsa-miR-140-3p BCL2 -0.0813609197213889 0.923953795876038 -0.330211405493396 0.555031371665433 PITA -0.113465055061337 0.033418865583585 hsa-miR-582-5p BCL2 -0.25536438153407 0.299823930850699 -0.330211405493396 0.555031371665433 PITA -0.224134268204108 9.13307546512698e-08 hsa-miR-142-5p PPP3CA -0.35195621065247 0.488286772825655 -0.078895894384611 0.886413963353503 PITA;mirMAP;miRNATAP -0.0517006705110423 0.010073687072875 hsa-miR-409-3p AKT1 -0.189095517827509 0.636954104687463 0.0626515976255728 0.927558384512439 PITA;miRNATAP -0.0856239280056138 2.47570922950619e-05 hsa-miR-140-5p BCL2L1 -0.310979285894735 0.512489148244786 0.150447773019176 0.810155517148199 PITA;miRanda;miRNATAP -0.178298678075701 1.10325405117987e-19 hsa-miR-326 BCL2L1 -0.134657725127161 0.690379143543161 0.150447773019176 0.810155517148199 PITA;miRanda;mirMAP;miRNATAP -0.0576122192334275 2.38634082141903e-07 hsa-miR-361-5p CASP7 0.0775639231585332 0.909963521897996 -0.119800196514739 0.803638561820115 PITA;miRanda -0.188787955079821 6.30808566269869e-06 hsa-miR-146b-5p PRKACA 0.00834882458611474 0.991577009242932 -0.0115056231029671 0.985176457562246 PITA -0.0531061870671599 0.000152525533332548 hsa-miR-532-5p PRKACB 0.0193679288578856 0.981424049788362 -0.0742837105484302 0.886731753016865 PITA -0.167904290632964 0.00255889279358267 hsa-miR-429 PRKAR1A -0.142589289838583 0.802317907773415 0.0481949802694981 0.9487025470248 PITA;miRanda;miRNATAP -0.0866170788967766 2.20564582838401e-10 hsa-miR-429 PRKAR2B -0.142589289838583 0.802317907773415 -0.0554605800632748 0.917605527457847 PITA;miRanda;miRNATAP -0.297037447890531 4.91028637474137e-21 hsa-miR-217 PIK3R3 -0.0872981480242543 0.809509315744678 -0.219842654525774 0.727127805779104 PITA;miRanda -0.118432783728797 1.05730160913028e-08 hsa-miR-423-5p PIK3R3 -0.0275038364546472 0.956931958131863 -0.219842654525774 0.727127805779104 PITA -0.0996413187322644 0.00826934400806009 hsa-miR-107 AKT3 -0.00374429919903285 0.994322461958742 -0.10604090651417 0.811944436836746 PITA;miRanda -0.322045444014362 3.05085750718847e-08 hsa-miR-320b AKT3 -0.0203395214664157 0.930562048282019 -0.10604090651417 0.811944436836746 PITA;miRanda;miRNATAP -0.080407312013421 0.0388522061576277 hsa-miR-769-5p AKT3 -0.10362464632991 0.793365222563107 -0.10604090651417 0.811944436836746 PITA;miRNATAP -0.188201328225218 0.000387633821142586 hsa-miR-508-3p PIK3R1 -0.000309617571689902 0.999135648467985 -0.161573746542345 0.805057044088694 PITA -0.0793279691478699 0.000380096225790872 hsa-miR-362-5p PRKACB 0.215268517371166 0.469421708227034 -0.0742837105484302 0.886731753016865 PITA -0.175108655019306 3.25359783331258e-06 hsa-let-7a-5p AIFM1 -0.0656092877172174 0.961124733677684 0.125157247739673 0.810026159590102 TargetScan;miRNATAP -0.196627166194514 1.22215321527312e-11 hsa-miR-17-5p AKT3 -0.0085894792332244 0.990927211793889 -0.10604090651417 0.811944436836746 TargetScan;miRNATAP -0.0978192612088338 0.00644441933410928 hsa-miR-17-5p CASP9 -0.0085894792332244 0.990927211793889 -0.0693081690352608 0.843810281844918 TargetScan -0.101631873053047 1.40876150138688e-14 hsa-let-7a-5p CHUK -0.0656092877172174 0.961124733677684 -0.00649042635415231 0.988335439566584 TargetScan -0.0710479768264423 0.00472464762527394 hsa-miR-200b-3p ENDOD1 -0.109983892590611 0.891357972128093 0.0942615531150564 0.862445027709995 TargetScan -0.0740541606577886 0.000460709238102638 hsa-let-7a-5p FAS -0.0656092877172174 0.961124733677684 -0.0598268469538907 0.867543041079802 TargetScan -0.147010045095826 0.00234531576557678 hsa-let-7a-5p FASLG -0.0656092877172174 0.961124733677684 -0.202775932032809 0.329163605225123 TargetScan;miRNATAP -0.254557236142898 0.0033640838487851 hsa-miR-96-5p PIK3CA -0.153312892459014 0.726115467443483 -0.12406162045663 0.780349649174885 TargetScan -0.158039482109614 1.06514304964241e-18 hsa-miR-200b-3p PIK3CA -0.109983892590611 0.891357972128093 -0.12406162045663 0.780349649174885 TargetScan -0.164394431071602 1.25931440199374e-17 hsa-miR-96-5p PIK3R1 -0.153312892459014 0.726115467443483 -0.161573746542345 0.805057044088694 TargetScan;miRNATAP -0.245653154038236 3.77424010710224e-23 hsa-miR-96-5p PPP3CA -0.153312892459014 0.726115467443483 -0.078895894384611 0.886413963353503 TargetScan -0.0887843307683919 1.70141567871087e-06 hsa-miR-17-5p PRKACB -0.0085894792332244 0.990927211793889 -0.0742837105484302 0.886731753016865 TargetScan -0.167470485926017 1.11326049159611e-05 hsa-miR-141-3p PRKAR1A -0.179420502124191 0.83354105481228 0.0481949802694981 0.9487025470248 TargetScan -0.0760644988397832 6.19736389532931e-08 hsa-miR-200b-3p PRKAR1A -0.109983892590611 0.891357972128093 0.0481949802694981 0.9487025470248 TargetScan -0.0947208174396913 5.87382968563215e-10 hsa-miR-200b-3p PRKAR2B -0.109983892590611 0.891357972128093 -0.0554605800632748 0.917605527457847 TargetScan -0.280997010338504 3.04124526480141e-15 hsa-miR-28-5p IKBKB -0.212713060051394 0.714914931441106 0.0975605327133957 0.86231928668593 miRanda -0.249159305195741 4.36298401628208e-09 hsa-miR-28-5p PIK3R3 -0.212713060051394 0.714914931441106 -0.219842654525774 0.727127805779104 miRanda -0.112036735701901 0.0141687305542462 hsa-miR-28-5p FADD -0.212713060051394 0.714914931441106 0.0857513186223438 0.854367424974715 miRanda -0.091580560756157 0.037502092834723 hsa-miR-28-5p PIK3R2 -0.212713060051394 0.714914931441106 0.0188890891833005 0.974660326807292 miRanda -0.170225138245223 4.06181677270291e-06 hsa-miR-107 PRKAR1A -0.00374429919903285 0.994322461958742 0.0481949802694981 0.9487025470248 miRanda -0.119959831304595 5.27363924798668e-05 hsa-miR-107 CAPN2 -0.00374429919903285 0.994322461958742 -0.0121103561755236 0.986646615645318 miRanda -0.176020877270818 2.30390840431672e-06 hsa-miR-107 IL1RAP -0.00374429919903285 0.994322461958742 -0.142375836605543 0.647003549805492 miRanda -0.354516667427086 5.43471185449583e-14 hsa-miR-107 PPP3CB -0.00374429919903285 0.994322461958742 0.0212980346837259 0.969289216388387 miRanda -0.128823034238509 4.39638835494672e-08 hsa-miR-107 CFLAR -0.00374429919903285 0.994322461958742 -0.0998206949739258 0.836577226313814 miRanda -0.135455220994877 0.000154859383776607 hsa-miR-107 PRKAR2B -0.00374429919903285 0.994322461958742 -0.0554605800632748 0.917605527457847 miRanda -0.229588564142726 0.000988045506014625 hsa-miR-107 CASP8 -0.00374429919903285 0.994322461958742 -0.149211527811264 0.731733266717747 miRanda -0.0812431363835575 0.00319234743054111 hsa-miR-199a-5p BID -0.0114843373708311 0.9900489817393 0.0152948145721421 0.97035763280396 miRanda -0.0781286750613544 0.000482257656097344 hsa-miR-199a-5p DFFB -0.0114843373708311 0.9900489817393 -0.0139931772031483 0.954936566867076 miRanda -0.0747842936223324 1.51654228012703e-05 hsa-miR-199a-5p AIFM1 -0.0114843373708311 0.9900489817393 0.125157247739673 0.810026159590102 miRanda -0.139410895318402 7.90792762480272e-14 hsa-miR-139-5p CASP3 0.00543145985495741 0.991591290852214 -0.00895575799140413 0.985101397582454 miRanda -0.133754697836399 1.82907069570434e-29 24885920 Ectopic expression of miR-139-5p in colon cancer cell lines significantly suppressed cell growth as evidenced by cell viability assay P < 0.001 and colony formation assay P < 0.01 and in xenograft tumor growth in nude mice P < 0.01 miR-139-5p induced apoptosis P < 0.01 concomitantly with up-regulation of key apoptosis genes including cleaved caspase-8 caspase-3 caspase-7 and PARP miR-139-5p also caused cell cycle arrest in G0/G1 phase P < 0.01 with upregulation of key G0/G1 phase regulators p21Cip1/Waf1 and p27Kip1 colorectal cancer hsa-miR-139-5p CYCS 0.00543145985495741 0.991591290852214 -0.018529217621003 0.976027349211284 miRanda -0.138771276194956 1.91475094017139e-21 hsa-miR-199b-5p BID -0.0420618710265854 0.953083764782006 0.0152948145721421 0.97035763280396 miRanda -0.0549512056964076 0.0066764617410712 hsa-miR-199b-5p DFFB -0.0420618710265854 0.953083764782006 -0.0139931772031483 0.954936566867076 miRanda -0.0640104670051696 4.22070997471132e-05 hsa-miR-140-5p CASP9 -0.310979285894735 0.512489148244786 -0.0693081690352608 0.843810281844918 miRanda -0.0877815995870104 7.7092915128073e-07 hsa-miR-140-5p IKBKG -0.310979285894735 0.512489148244786 0.0919116777306526 0.81175458483407 miRanda -0.125852887257061 2.14634764656029e-07 hsa-miR-140-5p CAPN1 -0.310979285894735 0.512489148244786 0.0407399138950622 0.952913838605964 miRanda;miRNATAP -0.124957501799464 4.3750761760043e-09 hsa-miR-142-3p BCL2 -0.419981832465888 0.660228548488659 -0.330211405493396 0.555031371665433 miRanda -0.1459796770776 3.09176521823541e-06 24895601 We identified three significantly associated mRNA-miRNA pairs: BCL2 was positively associated with miR-16 and SMAD4 was positively associated with miR-567 in the CRC tissue while MSH6 was positively associated with miR-142-5p in the normal tissue colorectal cancer hsa-miR-125a-5p IKBKG 0.00741438556537055 0.993308396064258 0.0919116777306526 0.81175458483407 miRanda -0.228007302003838 2.38576015741085e-19 hsa-miR-125a-5p CSF2RB 0.00741438556537055 0.993308396064258 -0.16285175934955 0.64748767357227 miRanda -0.342738630342494 5.64330349125e-13 hsa-miR-125a-5p AIFM1 0.00741438556537055 0.993308396064258 0.125157247739673 0.810026159590102 miRanda -0.0693217145644154 0.00326259910982751 hsa-miR-125a-3p CASP9 -0.0516703286850553 0.806463674361179 -0.0693081690352608 0.843810281844918 miRanda -0.0551989553795527 0.00125957597935056 hsa-miR-125a-3p IKBKB -0.0516703286850553 0.806463674361179 0.0975605327133957 0.86231928668593 miRanda -0.0739638500848602 0.0101797799615673 hsa-miR-125a-3p CASP6 -0.0516703286850553 0.806463674361179 -0.120407551207107 0.772118983668949 miRanda -0.0950391896779989 4.03043600976934e-05 hsa-miR-125a-3p ATM -0.0516703286850553 0.806463674361179 -0.14578960482531 0.7778082923952 miRanda -0.0746640426980332 0.00915936159355564 hsa-miR-125a-3p PIK3R2 -0.0516703286850553 0.806463674361179 0.0188890891833005 0.974660326807292 miRanda -0.078879458536794 0.00155335066312482 hsa-miR-127-3p BAD -0.160871868356278 0.844099901966483 0.125645252917708 0.78981599240697 miRanda;miRNATAP -0.12231920555334 5.77371456889348e-07 hsa-miR-193a-3p TNFRSF10C -0.0143163678163178 0.969244019090322 0.0859008622054023 0.624301627546532 miRanda -0.195687289553461 3.89035100008298e-05 hsa-miR-320a PRKAR1A 0.0425274543382255 0.958191670788918 0.0481949802694981 0.9487025470248 miRanda -0.0785393696029371 0.0046420228600667 hsa-miR-320a CASP7 0.0425274543382255 0.958191670788918 -0.119800196514739 0.803638561820115 miRanda -0.0656621524939966 0.01676540056397 hsa-miR-320a PIK3R2 0.0425274543382255 0.958191670788918 0.0188890891833005 0.974660326807292 miRanda -0.151022063052727 3.16338469232646e-07 hsa-miR-34c-5p PPP3R1 0.0263265725823381 0.923214932412527 -0.0271826487262787 0.962679518571233 miRanda -0.093920369071247 4.84069239951161e-14 hsa-miR-34c-5p DFFA 0.0263265725823381 0.923214932412527 -0.00803186454841942 0.98442469177585 miRanda -0.0528661287547162 3.5725154981475e-05 hsa-miR-34c-5p CYCS 0.0263265725823381 0.923214932412527 -0.018529217621003 0.976027349211284 miRanda -0.106641084379626 4.91599767479111e-11 hsa-miR-34c-5p CFLAR 0.0263265725823381 0.923214932412527 -0.0998206949739258 0.836577226313814 miRanda -0.0660712806115081 0.000839478658261615 hsa-miR-361-5p IL1RAP 0.0775639231585332 0.909963521897996 -0.142375836605543 0.647003549805492 miRanda -0.13779740341553 0.0436226151133564 hsa-miR-361-5p TNFSF10 0.0775639231585332 0.909963521897996 -0.197812618297202 0.765914684971228 miRanda -0.460395837819847 1.02300973229871e-08 hsa-miR-361-5p XIAP 0.0775639231585332 0.909963521897996 -0.0212306078731803 0.970140712022331 miRanda -0.23192032963789 1.40068436460593e-11 hsa-miR-361-5p PPP3CA 0.0775639231585332 0.909963521897996 -0.078895894384611 0.886413963353503 miRanda -0.244052441662145 8.38230854446672e-06 hsa-miR-361-5p PPP3CB 0.0775639231585332 0.909963521897996 0.0212980346837259 0.969289216388387 miRanda -0.218861370922051 6.00579314883281e-11 hsa-miR-361-5p PRKAR2A 0.0775639231585332 0.909963521897996 -0.149339211195881 0.695378435991995 miRanda -0.7784380971036 6.37302709255488e-21 hsa-miR-361-5p PRKACB 0.0775639231585332 0.909963521897996 -0.0742837105484302 0.886731753016865 miRanda -0.31917046064862 0.000326749716630808 hsa-miR-330-5p IRAK3 -0.0582594636115701 0.896794748650637 -0.269594472929764 0.440968215803154 miRanda -0.20802901259839 7.14318546182645e-05 hsa-miR-330-5p IKBKB -0.0582594636115701 0.896794748650637 0.0975605327133957 0.86231928668593 miRanda -0.115452535316074 6.19261343388698e-05 hsa-miR-330-5p TNFRSF10C -0.0582594636115701 0.896794748650637 0.0859008622054023 0.624301627546532 miRanda -0.11546683711462 0.0189927538388668 hsa-miR-342-3p PIK3CD -0.244092268513731 0.741215180994683 -0.147433448424908 0.694309739932742 miRanda -0.0605371415556833 0.0277825923518098 hsa-miR-342-3p TRADD -0.244092268513731 0.741215180994683 0.125409014371577 0.7338485707446 miRanda -0.0534091610915603 0.0233119082047102 hsa-miR-342-3p TNFRSF1A -0.244092268513731 0.741215180994683 0.0501674719580505 0.935452447515846 miRanda -0.0786703223872156 1.01346697256229e-09 hsa-miR-326 IKBKB -0.134657725127161 0.690379143543161 0.0975605327133957 0.86231928668593 miRanda -0.0683712153154769 4.25003865906222e-05 hsa-miR-326 BAD -0.134657725127161 0.690379143543161 0.125645252917708 0.78981599240697 miRanda -0.162992963378128 2.73003852781454e-21 hsa-miR-326 TNFRSF10C -0.134657725127161 0.690379143543161 0.0859008622054023 0.624301627546532 miRanda -0.0987723731295568 0.00052290639909179 hsa-miR-324-5p IKBKB -0.166270923976542 0.685489008903759 0.0975605327133957 0.86231928668593 miRanda -0.118429787871439 3.07201825932054e-08 hsa-miR-324-5p IRAK3 -0.166270923976542 0.685489008903759 -0.269594472929764 0.440968215803154 miRanda -0.179294712941118 4.21304683087341e-06 hsa-miR-338-3p FAS -0.00932885158849928 0.989745642009026 -0.0598268469538907 0.867543041079802 miRanda -0.16768795837118 1.3473835302647e-10 hsa-miR-338-3p CASP10 -0.00932885158849928 0.989745642009026 0.137538027972401 0.674204872280143 miRanda -0.135288528791404 8.56458851996976e-07 hsa-miR-338-3p CFLAR -0.00932885158849928 0.989745642009026 -0.0998206949739258 0.836577226313814 miRanda;mirMAP -0.121412509761298 6.80132044970643e-09 hsa-miR-339-5p TNFRSF10D -0.119339443611091 0.808593831380581 -0.162621844415897 0.456246821319228 miRanda -0.107235749860043 0.0251186801186918 hsa-miR-429 NGF -0.142589289838583 0.802317907773415 0.0421653122976033 0.823871342075226 miRanda -0.12206490353919 1.36541405382157e-05 hsa-miR-429 PPP3CB -0.142589289838583 0.802317907773415 0.0212980346837259 0.969289216388387 miRanda -0.0818697708421961 3.72837740995173e-14 hsa-miR-429 IRAK3 -0.142589289838583 0.802317907773415 -0.269594472929764 0.440968215803154 miRanda -0.334670000939921 3.85801572773716e-29 hsa-miR-429 ENDOD1 -0.142589289838583 0.802317907773415 0.0942615531150564 0.862445027709995 miRanda;miRNATAP -0.0797821568782325 2.30721578744705e-05 hsa-miR-486-5p BCL2L1 0.00521803679905908 0.992702666093128 0.150447773019176 0.810155517148199 miRanda -0.0645921907270345 8.04100841261354e-13 hsa-miR-491-5p CAPN1 -0.423577120749209 0.0220584227099558 0.0407399138950622 0.952913838605964 miRanda -0.0824977452943085 7.60009573040895e-07 hsa-miR-491-5p PRKAR1B -0.423577120749209 0.0220584227099558 0.112247181774356 0.731436264308265 miRanda -0.157141338101157 3.59668087391003e-09 hsa-miR-491-5p PIK3R2 -0.423577120749209 0.0220584227099558 0.0188890891833005 0.974660326807292 miRanda -0.116485616092769 7.44579853361516e-09 hsa-miR-491-5p IKBKB -0.423577120749209 0.0220584227099558 0.0975605327133957 0.86231928668593 miRanda -0.0669106572529719 0.00427687466737305 hsa-miR-146b-5p IKBKB 0.00834882458611474 0.991577009242932 0.0975605327133957 0.86231928668593 miRanda -0.152908526927625 4.45729055656516e-09 hsa-miR-146b-5p PPP3CB 0.00834882458611474 0.991577009242932 0.0212980346837259 0.969289216388387 miRanda -0.171198371090796 2.36585494803099e-25 hsa-miR-146b-5p PRKAR2A 0.00834882458611474 0.991577009242932 -0.149339211195881 0.695378435991995 miRanda -0.273919400111088 8.1738277985017e-11 hsa-miR-455-5p ATM -0.196032525410701 0.627038966906064 -0.14578960482531 0.7778082923952 miRanda -0.0885803347564059 8.80467476133545e-05 hsa-miR-455-5p TNFSF10 -0.196032525410701 0.627038966906064 -0.197812618297202 0.765914684971228 miRanda -0.163295270434549 3.10292271839683e-06 hsa-miR-455-5p CASP8 -0.196032525410701 0.627038966906064 -0.149211527811264 0.731733266717747 miRanda -0.0712574742724173 2.82999798260657e-05 hsa-miR-590-5p PRKAR1A -0.131787544750195 0.684613701486826 0.0481949802694981 0.9487025470248 miRanda -0.0717152792567287 0.000169558335712392 hsa-miR-590-5p BCL2 -0.131787544750195 0.684613701486826 -0.330211405493396 0.555031371665433 miRanda -0.432407489499855 2.16078449133157e-23 hsa-miR-590-5p TNFRSF10D -0.131787544750195 0.684613701486826 -0.162621844415897 0.456246821319228 miRanda -0.146941086633069 0.000532817357731842 hsa-miR-590-3p PRKAR1A -0.133358268237272 0.535686159072243 0.0481949802694981 0.9487025470248 miRanda;mirMAP -0.0770812782570997 0.000111795871636507 hsa-miR-590-3p IKBKB -0.133358268237272 0.535686159072243 0.0975605327133957 0.86231928668593 miRanda;mirMAP -0.100127823485223 4.7662908944255e-05 hsa-miR-590-3p BCL2 -0.133358268237272 0.535686159072243 -0.330211405493396 0.555031371665433 miRanda;mirMAP -0.386064412166968 3.36735476522038e-17 hsa-miR-590-3p PIK3R1 -0.133358268237272 0.535686159072243 -0.161573746542345 0.805057044088694 miRanda;mirMAP -0.239713681587516 7.2007499793076e-12 hsa-miR-590-3p IL1R1 -0.133358268237272 0.535686159072243 -0.0897068964064003 0.872943387530182 miRanda;miRNATAP -0.200131921987377 7.85936325921516e-08 hsa-miR-590-3p PPP3CB -0.133358268237272 0.535686159072243 0.0212980346837259 0.969289216388387 miRanda -0.0821026738846212 2.15159070834418e-07 hsa-miR-590-3p IRAK3 -0.133358268237272 0.535686159072243 -0.269594472929764 0.440968215803154 miRanda;mirMAP -0.296371249555745 2.39675147488628e-11 hsa-miR-590-3p TNFRSF10D -0.133358268237272 0.535686159072243 -0.162621844415897 0.456246821319228 miRanda -0.26076122341674 3.34240440642948e-09 hsa-miR-542-3p CASP8 0.11706603007597 0.867078497673182 -0.149211527811264 0.731733266717747 miRanda -0.0576942943651073 0.00377056883635573 hsa-miR-542-3p ATM 0.11706603007597 0.867078497673182 -0.14578960482531 0.7778082923952 miRanda -0.0838991311650017 0.00148551942126324 hsa-miR-320b CASP7 -0.0203395214664157 0.930562048282019 -0.119800196514739 0.803638561820115 miRanda -0.0677457252123518 0.000516591467790574 hsa-miR-320b CASP10 -0.0203395214664157 0.930562048282019 0.137538027972401 0.674204872280143 miRanda -0.0624999098138181 0.045246997728814 hsa-miR-320b PPP3CB -0.0203395214664157 0.930562048282019 0.0212980346837259 0.969289216388387 miRanda -0.0583923552164271 0.000200849550100936 hsa-miR-320b IRAK3 -0.0203395214664157 0.930562048282019 -0.269594472929764 0.440968215803154 miRanda -0.170503311378059 0.000115799815404031 hsa-miR-125a-5p CASP10 0.00741438556537055 0.993308396064258 0.137538027972401 0.674204872280143 mirMAP -0.177820442824944 1.14974523663095e-05 hsa-miR-181a-5p CASP10 0.0637093750406734 0.945876131429707 0.137538027972401 0.674204872280143 mirMAP -0.167506455297156 2.81512484479157e-05 hsa-miR-181b-5p CASP10 0.0375130667115933 0.959555096276237 0.137538027972401 0.674204872280143 mirMAP -0.167102695297352 7.08258362002032e-07 hsa-miR-181c-5p CASP10 -0.18121298802215 0.718350072627076 0.137538027972401 0.674204872280143 mirMAP -0.286608402089331 2.10718338906629e-17 hsa-miR-19b-1-5p CASP10 -0.126966953724701 0.619571308879527 0.137538027972401 0.674204872280143 mirMAP -0.145110342832673 2.51939892977316e-06 hsa-miR-21-5p CASP10 0.0148493782366828 0.992419670576308 0.137538027972401 0.674204872280143 mirMAP -0.182489722562965 2.9340743714182e-07 hsa-miR-125a-3p CASP10 -0.0516703286850553 0.806463674361179 0.137538027972401 0.674204872280143 mirMAP -0.0755805503028166 0.0400845221357132 hsa-miR-200b-3p CASP10 -0.109983892590611 0.891357972128093 0.137538027972401 0.674204872280143 mirMAP -0.239445518155442 5.07791301456485e-24 hsa-miR-200c-3p CASP10 -0.0449560636499466 0.969433069399071 0.137538027972401 0.674204872280143 mirMAP -0.273509969637675 6.53447298083599e-26 hsa-miR-429 CASP10 -0.142589289838583 0.802317907773415 0.137538027972401 0.674204872280143 mirMAP;miRNATAP -0.212886532614725 8.1773549392356e-24 hsa-miR-454-3p CFLAR -0.0807547300787816 0.779337172929459 -0.0998206949739258 0.836577226313814 mirMAP -0.0853959126857351 7.54285789154826e-05 hsa-let-7a-3p PRKAR2B -0.130729276906521 0.779692030572974 -0.0554605800632748 0.917605527457847 mirMAP -0.136763621754375 0.0318102271263184 hsa-let-7f-1-3p PRKAR2B -0.222769653030984 0.176243975299018 -0.0554605800632748 0.917605527457847 mirMAP -0.146699506826546 0.0033120259534399 hsa-miR-450b-5p PRKAR2B 0.140781738083346 0.700777724167455 -0.0554605800632748 0.917605527457847 mirMAP;miRNATAP -0.15718172389387 0.00131925936989063 hsa-miR-664a-3p BIRC3 0.0260321839026805 0.956434140422838 -0.351018966497297 0.384034819284766 mirMAP -0.161690203472487 0.00216600443131899 hsa-miR-148b-3p IKBKG -0.121415535518017 0.85232232285121 0.0919116777306526 0.81175458483407 mirMAP -0.0677298609530004 0.00911616230340407 hsa-miR-335-5p IKBKG -0.0216107337976461 0.95157247156319 0.0919116777306526 0.81175458483407 mirMAP -0.087449683262756 7.80491191394984e-11 hsa-miR-3607-3p IKBKG -0.410705558355355 0.442005238257379 0.0919116777306526 0.81175458483407 mirMAP -0.123479124494569 5.75170407705992e-24 hsa-miR-141-3p IRAK3 -0.179420502124191 0.83354105481228 -0.269594472929764 0.440968215803154 mirMAP -0.395371091533372 5.07583894364656e-39 hsa-miR-16-1-3p IRAK3 -0.172993537212073 0.391863504419512 -0.269594472929764 0.440968215803154 mirMAP -0.317549883095679 9.31936816646031e-11 hsa-miR-16-2-3p IRAK3 -0.107555719075227 0.702302679752719 -0.269594472929764 0.440968215803154 mirMAP -0.204410225746941 2.94894686008826e-06 hsa-miR-200a-3p IRAK3 -0.192839143060886 0.77994979695622 -0.269594472929764 0.440968215803154 mirMAP -0.318261128528154 5.73130945956319e-26 hsa-miR-21-5p IRAK3 0.0148493782366828 0.992419670576308 -0.269594472929764 0.440968215803154 mirMAP -0.432949994242884 3.91318586050703e-18 hsa-miR-25-3p IRAK3 0.0550592306329012 0.962829613775088 -0.269594472929764 0.440968215803154 mirMAP -0.152116924877084 0.0360737139831497 hsa-miR-32-5p IRAK3 -0.218686304292785 0.59094441655546 -0.269594472929764 0.440968215803154 mirMAP -0.340329221828206 3.39112214525709e-13 hsa-miR-330-3p IRAK3 -0.00366157141494194 0.98416704678615 -0.269594472929764 0.440968215803154 mirMAP -0.131278534076491 0.00452992739410884 hsa-miR-33a-5p IRAK3 -0.215117012664838 0.532123464324836 -0.269594472929764 0.440968215803154 mirMAP -0.156967006595365 2.52311898361291e-08 hsa-miR-340-5p IRAK3 0.0820090452273905 0.816484190854532 -0.269594472929764 0.440968215803154 mirMAP -0.221921373949816 1.17405342424141e-05 hsa-miR-590-5p IRAK3 -0.131787544750195 0.684613701486826 -0.269594472929764 0.440968215803154 mirMAP -0.272908984767146 1.27456596403924e-10 hsa-miR-660-5p IRAK3 0.0681681272574144 0.880554662781555 -0.269594472929764 0.440968215803154 mirMAP -0.190008554834879 0.000251329156707178 hsa-miR-7-1-3p IRAK3 -0.0332815306858167 0.935725386085843 -0.269594472929764 0.440968215803154 mirMAP -0.242971494797642 1.1381655944653e-08 hsa-miR-92b-3p IRAK3 -0.0975289498867111 0.871999313512183 -0.269594472929764 0.440968215803154 mirMAP -0.192303735024889 6.79786003585688e-06 hsa-miR-125b-2-3p XIAP -0.19521949049782 0.618072714328679 -0.0212306078731803 0.970140712022331 mirMAP -0.056161556432256 1.69458645598678e-05 hsa-miR-140-3p XIAP -0.0813609197213889 0.923953795876038 -0.0212306078731803 0.970140712022331 mirMAP -0.175849683596678 4.89061522526325e-22 hsa-miR-142-5p XIAP -0.35195621065247 0.488286772825655 -0.0212306078731803 0.970140712022331 mirMAP;miRNATAP -0.0614158965485318 1.13382862136084e-06 hsa-miR-146a-5p XIAP -0.362125606043493 0.545323292976414 -0.0212306078731803 0.970140712022331 mirMAP -0.0761188555616922 3.2353968357798e-08 hsa-miR-146b-5p XIAP 0.00834882458611474 0.991577009242932 -0.0212306078731803 0.970140712022331 mirMAP;miRNATAP -0.159991507133537 4.74881632481789e-21 hsa-miR-16-1-3p XIAP -0.172993537212073 0.391863504419512 -0.0212306078731803 0.970140712022331 mirMAP -0.0657364766640783 0.000264696155378108 hsa-miR-16-2-3p XIAP -0.107555719075227 0.702302679752719 -0.0212306078731803 0.970140712022331 mirMAP -0.0525851722505888 0.00100906480808771 hsa-miR-181a-2-3p XIAP -0.129301605775352 0.87844748146472 -0.0212306078731803 0.970140712022331 mirMAP -0.0708490593086054 0.00199973027146465 hsa-miR-181c-5p XIAP -0.18121298802215 0.718350072627076 -0.0212306078731803 0.970140712022331 mirMAP -0.0947822705748445 8.8973390255929e-08 hsa-miR-19a-3p XIAP -0.00951638786771092 0.980991306004163 -0.0212306078731803 0.970140712022331 mirMAP -0.103112921623755 1.53894494824873e-14 hsa-miR-19b-3p XIAP -0.0314903804749491 0.95913844863355 -0.0212306078731803 0.970140712022331 mirMAP -0.098104091532541 3.21935960716837e-09 hsa-miR-25-3p XIAP 0.0550592306329012 0.962829613775088 -0.0212306078731803 0.970140712022331 mirMAP -0.178365306123466 8.69234553825738e-12 hsa-miR-32-5p XIAP -0.218686304292785 0.59094441655546 -0.0212306078731803 0.970140712022331 mirMAP -0.0515352461126279 0.0028422696253826 hsa-miR-340-5p XIAP 0.0820090452273905 0.816484190854532 -0.0212306078731803 0.970140712022331 mirMAP;miRNATAP -0.127382401281156 3.40040901491278e-12 hsa-miR-361-3p XIAP -0.0127254134873924 0.984476698818773 -0.0212306078731803 0.970140712022331 mirMAP -0.168890865663792 3.66560347189809e-10 hsa-miR-374a-3p XIAP -0.0781632437076389 0.926379383884834 -0.0212306078731803 0.970140712022331 mirMAP -0.0927927258817931 0.00025351020383903 hsa-miR-500a-5p XIAP 0.0097790305601746 0.958449089566593 -0.0212306078731803 0.970140712022331 mirMAP;miRNATAP -0.129892682453372 7.13179467986375e-18 hsa-miR-532-5p XIAP 0.0193679288578856 0.981424049788362 -0.0212306078731803 0.970140712022331 mirMAP -0.163157908700779 2.48323565162108e-14 hsa-miR-708-3p XIAP -0.0786820348913011 0.88886515820271 -0.0212306078731803 0.970140712022331 mirMAP -0.0520348791212327 0.00399553072517755 hsa-miR-92a-3p XIAP -0.0230307937945682 0.984317735692711 -0.0212306078731803 0.970140712022331 mirMAP -0.147544420242899 1.12077603559433e-13 hsa-miR-125b-5p AKT2 -0.0598851546678105 0.945288350565791 0.0504008323501575 0.936738544702785 mirMAP -0.0930859642207501 1.21084801483443e-08 hsa-miR-140-5p AKT2 -0.310979285894735 0.512489148244786 0.0504008323501575 0.936738544702785 mirMAP -0.0847901004525692 4.32835916630645e-05 hsa-miR-214-3p AKT2 -0.110449829460212 0.670567263185672 0.0504008323501575 0.936738544702785 mirMAP -0.0508273289887318 0.000790125135260176 hsa-miR-22-3p AKT2 -0.0230458302155654 0.987273023087919 0.0504008323501575 0.936738544702785 mirMAP -0.0643175793759184 0.0378951538762392 hsa-miR-2355-5p AKT2 -0.0815180829196089 0.870082450607981 0.0504008323501575 0.936738544702785 mirMAP -0.0864963541114231 7.90014184265494e-05 hsa-miR-24-3p AKT2 -0.156339520113363 0.865374272536865 0.0504008323501575 0.936738544702785 mirMAP -0.108581040434418 8.76204903485834e-07 hsa-miR-30e-3p AKT2 -0.159454066602024 0.887830180332455 0.0504008323501575 0.936738544702785 mirMAP -0.10769217628588 0.000202699653075448 hsa-miR-628-5p AKT2 -0.425043070183919 0.319271894365573 0.0504008323501575 0.936738544702785 mirMAP -0.0728541565846892 7.13448218834998e-11 hsa-miR-766-3p AKT2 -0.147271179662174 0.609930564272633 0.0504008323501575 0.936738544702785 mirMAP -0.0910081394290331 5.87027089463391e-08 hsa-miR-539-5p PIK3R2 -0.223963250948171 0.453655442416551 0.0188890891833005 0.974660326807292 mirMAP -0.0852212015594246 5.06614453952456e-08 hsa-miR-381-3p PRKAR1A -0.0215856799485721 0.961260144775191 0.0481949802694981 0.9487025470248 mirMAP -0.0656247625815646 0.000531330367549388 hsa-miR-30e-5p PRKAR1A -0.183864098532103 0.86939509445488 0.0481949802694981 0.9487025470248 mirMAP -0.135180536556767 8.0116702940993e-06 hsa-miR-142-5p PRKAR2A -0.35195621065247 0.488286772825655 -0.149339211195881 0.695378435991995 mirMAP -0.0792351806012059 0.0106915921539582 hsa-miR-148a-5p PRKAR2A -0.200917166615887 0.667057353234933 -0.149339211195881 0.695378435991995 mirMAP -0.172687337443351 2.57585400519544e-05 hsa-miR-182-5p PRKAR2A -0.101509746042318 0.939206381321837 -0.149339211195881 0.695378435991995 mirMAP -0.0946749598936538 0.00636303816330032 hsa-miR-21-5p PRKAR2A 0.0148493782366828 0.992419670576308 -0.149339211195881 0.695378435991995 mirMAP -0.342627756886755 1.81049457969324e-14 hsa-miR-25-3p PRKAR2A 0.0550592306329012 0.962829613775088 -0.149339211195881 0.695378435991995 mirMAP -0.285901092503133 9.17213733067375e-06 hsa-miR-26a-5p PRKAR2A -0.0558466394626773 0.953979749143751 -0.149339211195881 0.695378435991995 mirMAP -0.267807878494749 4.77261329832618e-05 hsa-miR-320a PRKAR2A 0.0425274543382255 0.958191670788918 -0.149339211195881 0.695378435991995 mirMAP -0.18245994665913 0.00100676430812175 hsa-miR-320b PRKAR2A -0.0203395214664157 0.930562048282019 -0.149339211195881 0.695378435991995 mirMAP -0.0993284275433938 0.0120452105629341 hsa-miR-32-5p PRKAR2A -0.218686304292785 0.59094441655546 -0.149339211195881 0.695378435991995 mirMAP -0.21153205232007 4.9203673053638e-07 hsa-miR-330-3p PRKAR2A -0.00366157141494194 0.98416704678615 -0.149339211195881 0.695378435991995 mirMAP -0.0896026949809388 0.0300373077251987 hsa-miR-3913-5p PRKAR2A -0.0522230839821796 0.748170987254748 -0.149339211195881 0.695378435991995 mirMAP -0.287042647112917 9.2693710730762e-09 hsa-miR-106b-5p PRKAR2A -0.0853499657102335 0.901700669947609 -0.149339211195881 0.695378435991995 mirMAP -0.406481597420149 4.72151259322544e-19 hsa-miR-17-5p PRKAR2A -0.0085894792332244 0.990927211793889 -0.149339211195881 0.695378435991995 mirMAP -0.142029585393759 9.67819842669458e-05 hsa-miR-20a-5p PRKAR2A 0.0648697217907399 0.924634007033878 -0.149339211195881 0.695378435991995 mirMAP -0.317770709661877 1.62622898454047e-17 hsa-miR-17-3p IL1R1 -0.00462206849027691 0.994608252674318 -0.0897068964064003 0.872943387530182 mirMAP -0.264058620225795 1.43612311566876e-11 hsa-miR-181b-5p IL1R1 0.0375130667115933 0.959555096276237 -0.0897068964064003 0.872943387530182 mirMAP -0.0962193418568757 0.0168811415302622 hsa-miR-30d-3p IL1R1 0.010689376681901 0.963707546423024 -0.0897068964064003 0.872943387530182 mirMAP -0.226015646684785 1.68705773637213e-06 hsa-miR-130b-5p IL1R1 -0.24592404944858 0.439156866715699 -0.0897068964064003 0.872943387530182 mirMAP -0.134792075843703 9.62989300771142e-06 hsa-miR-29b-2-5p AKT3 -0.0126563776248076 0.980563872976574 -0.10604090651417 0.811944436836746 mirMAP -0.174192327083419 4.9828909918003e-06 hsa-miR-340-5p AKT3 0.0820090452273905 0.816484190854532 -0.10604090651417 0.811944436836746 mirMAP -0.283834227072162 1.26866636163553e-10 hsa-miR-1271-5p PIK3R3 -0.212089092939039 0.308630501141543 -0.219842654525774 0.727127805779104 mirMAP -0.0507738302353108 0.0156365578539244 hsa-miR-335-3p PIK3R3 0.248840023734261 0.661533599343062 -0.219842654525774 0.727127805779104 mirMAP -0.0875220950865652 9.72728768340981e-06 hsa-miR-374a-5p PIK3R3 -0.0192159163584709 0.965315201402842 -0.219842654525774 0.727127805779104 mirMAP -0.121442827230575 0.0029020400924295 hsa-miR-374b-5p PIK3R3 -0.0341588728964348 0.947017013085837 -0.219842654525774 0.727127805779104 mirMAP -0.120196538768652 0.00271578207935794 hsa-miR-381-3p PIK3R3 -0.0215856799485721 0.961260144775191 -0.219842654525774 0.727127805779104 mirMAP -0.140767078074606 1.38941193259491e-08 hsa-miR-495-3p PIK3R3 -0.159204559213757 0.555240058524588 -0.219842654525774 0.727127805779104 mirMAP -0.0507393485926794 0.0281179941421916 hsa-miR-532-5p PIK3R3 0.0193679288578856 0.981424049788362 -0.219842654525774 0.727127805779104 mirMAP -0.140279487612118 5.85354025061255e-05 hsa-miR-374a-5p APAF1 -0.0192159163584709 0.965315201402842 -0.0751479999846154 0.860066851482364 mirMAP -0.0783165625829351 0.00537528778569007 hsa-miR-146b-5p PIK3CA 0.00834882458611474 0.991577009242932 -0.12406162045663 0.780349649174885 mirMAP -0.10172531442561 0.000163300940659646 hsa-miR-148a-5p PIK3CA -0.200917166615887 0.667057353234933 -0.12406162045663 0.780349649174885 mirMAP -0.111623090383025 1.82115916734019e-05 hsa-miR-361-5p PIK3CA 0.0775639231585332 0.909963521897996 -0.12406162045663 0.780349649174885 mirMAP -0.28523073173792 1.02307804662151e-07 hsa-miR-450b-5p PIK3CA 0.140781738083346 0.700777724167455 -0.12406162045663 0.780349649174885 mirMAP -0.0658260874488932 0.0131395739197979 hsa-miR-130b-5p CASP9 -0.24592404944858 0.439156866715699 -0.0693081690352608 0.843810281844918 mirMAP -0.06427483229084 6.6636771091185e-08 hsa-miR-16-5p CASP9 -0.131938295863899 0.869419037928521 -0.0693081690352608 0.843810281844918 mirMAP -0.0588478103623232 0.00155927742047269 hsa-miR-186-5p CASP9 -0.14779866926096 0.840248407765158 -0.0693081690352608 0.843810281844918 mirMAP -0.0906549399738287 1.48930756143294e-06 hsa-miR-199a-3p CASP9 -0.115440021652793 0.912942630248289 -0.0693081690352608 0.843810281844918 mirMAP -0.0693168390773851 7.80573183798492e-06 hsa-miR-199b-3p CASP9 -0.117157552965615 0.911609413213755 -0.0693081690352608 0.843810281844918 mirMAP -0.0693133595972469 7.30830726751583e-06 hsa-miR-222-5p CASP9 -0.42274874322057 0.0487796396911282 -0.0693081690352608 0.843810281844918 mirMAP -0.0686821187208886 8.64285338114226e-08 hsa-miR-374a-3p RIPK1 -0.0781632437076389 0.926379383884834 -0.00624459434673863 0.990346024302325 mirMAP -0.0606932576679978 0.000687693685190358 hsa-miR-340-5p PPP3CA 0.0820090452273905 0.816484190854532 -0.078895894384611 0.886413963353503 mirMAP -0.176067551771713 1.43168876315375e-09 hsa-miR-16-2-3p PRKACB -0.107555719075227 0.702302679752719 -0.0742837105484302 0.886731753016865 mirMAP -0.0941100915668049 0.0219233623396869 hsa-miR-30d-3p PRKACB 0.010689376681901 0.963707546423024 -0.0742837105484302 0.886731753016865 mirMAP -0.251818481172515 1.82407867076559e-06 hsa-miR-340-5p PRKACB 0.0820090452273905 0.816484190854532 -0.0742837105484302 0.886731753016865 mirMAP -0.151842813986032 0.001373090709035 hsa-miR-200b-3p PIK3R1 -0.109983892590611 0.891357972128093 -0.161573746542345 0.805057044088694 mirMAP -0.193888157381114 6.36921236487692e-13 hsa-miR-200c-3p PIK3R1 -0.0449560636499466 0.969433069399071 -0.161573746542345 0.805057044088694 mirMAP -0.257145031020416 2.3912254219973e-18 hsa-miR-429 PIK3R1 -0.142589289838583 0.802317907773415 -0.161573746542345 0.805057044088694 mirMAP;miRNATAP -0.22503499935046 3.34180951947627e-21 hsa-miR-589-3p PIK3R1 -0.0679748049633819 0.703146664597157 -0.161573746542345 0.805057044088694 mirMAP -0.0663066514868586 0.0215445178897342 hsa-miR-16-1-3p ENDOD1 -0.172993537212073 0.391863504419512 0.0942615531150564 0.862445027709995 mirMAP -0.0621476718056317 0.0403540715971897 hsa-miR-21-5p ATM 0.0148493782366828 0.992419670576308 -0.14578960482531 0.7778082923952 mirMAP -0.230974664847653 3.0596374789676e-17 hsa-miR-500a-5p ATM 0.0097790305601746 0.958449089566593 -0.14578960482531 0.7778082923952 mirMAP -0.0826527067882432 0.000341286701460457 hsa-miR-214-3p BCL2L1 -0.110449829460212 0.670567263185672 0.150447773019176 0.810155517148199 mirMAP -0.0576447541283191 7.91482275500326e-05 hsa-miR-361-3p BCL2L1 -0.0127254134873924 0.984476698818773 0.150447773019176 0.810155517148199 mirMAP -0.0574658366447505 0.0367960940686246 24491557 Signal transducer and activator of transcription-6 STAT6 a direct target of miR-361-5p enhances the expression of B-cell lymphoma-extra large Bcl-xL while miR-361-5p inhibits its expression through STAT6 prostate cancer hsa-miR-16-1-3p BCL2 -0.172993537212073 0.391863504419512 -0.330211405493396 0.555031371665433 mirMAP -0.226601532507069 1.00488294259221e-05 23867991;18931683 miR-15a and miR-16-1 are important tumor suppressors through modulating B cell lymphoma 2 Bcl-2 Cyclin D1 D2 and others;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2 ; lung cancer;prostate cancer hsa-miR-186-5p BCL2 -0.14779866926096 0.840248407765158 -0.330211405493396 0.555031371665433 mirMAP -0.348265462226792 5.09173882444383e-09 hsa-miR-542-3p BCL2 0.11706603007597 0.867078497673182 -0.330211405493396 0.555031371665433 mirMAP -0.198415663601992 7.32195879993002e-05 hsa-miR-130b-5p BCL2 -0.24592404944858 0.439156866715699 -0.330211405493396 0.555031371665433 mirMAP -0.298072526149562 1.58526199405774e-15 hsa-miR-15b-3p BCL2 -0.126451993800397 0.773147230209712 -0.330211405493396 0.555031371665433 mirMAP -0.310741788828047 6.78718604611496e-16 18449891;18449891;18449891 miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells;The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein;Enforced mir-15b or miR-16 expression reduced Bcl-2 protein level and the luciferase activity of a BCL2 3' untranslated region-based reporter construct in SGC7901/VCR cells suggesting that BCL2 is a direct target of miR-15b and miR-16 drug resistance;;; stomach cancer;stomach cancer;stomach cancer hsa-miR-16-2-3p BCL2 -0.107555719075227 0.702302679752719 -0.330211405493396 0.555031371665433 mirMAP -0.220617147018903 1.20839624748242e-06 hsa-miR-20a-3p BCL2 -0.267112043185936 0.342386318550293 -0.330211405493396 0.555031371665433 mirMAP -0.13906123260096 9.78039595655978e-05 hsa-miR-224-5p BCL2 -0.101100511980041 0.824356781792172 -0.330211405493396 0.555031371665433 mirMAP -0.241222882395465 2.18051025428057e-28 24796455;22989374;22989374 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01;The high-ranking genes CDC42 CDH1 PAK2 BCL-2 and MAPK1 were confirmed as important targets of miR-224 and involvement in hepatocarcinogenesis;Overexpression of miR-224 significantly in Hek293 and Huh7 cells altered the expression levels of CDC42 CDH1 PAK2 and BCL-2 at both mRNA and protein levels ;tumorigenesis;; stomach cancer;liver cancer;liver cancer hsa-miR-29a-5p BCL2 -0.242897712652954 0.339681975959217 -0.330211405493396 0.555031371665433 mirMAP -0.158728142208395 0.00138976145130829 hsa-miR-33a-5p BCL2 -0.215117012664838 0.532123464324836 -0.330211405493396 0.555031371665433 mirMAP -0.201771252418707 4.45169669138265e-12 hsa-miR-374a-5p BCL2 -0.0192159163584709 0.965315201402842 -0.330211405493396 0.555031371665433 mirMAP -0.330216657607334 4.44639283995132e-06 hsa-miR-374b-5p BCL2 -0.0341588728964348 0.947017013085837 -0.330211405493396 0.555031371665433 mirMAP -0.283877494124907 6.14149967949098e-05 hsa-miR-409-3p BCL2 -0.189095517827509 0.636954104687463 -0.330211405493396 0.555031371665433 mirMAP -0.140997687582626 0.00424621383085417 hsa-miR-450b-5p BCL2 0.140781738083346 0.700777724167455 -0.330211405493396 0.555031371665433 mirMAP -0.230258059009763 2.05822889351104e-06 hsa-miR-452-5p BCL2 -0.0590392811106577 0.906930362717493 -0.330211405493396 0.555031371665433 mirMAP -0.281160548783898 1.07099917549241e-26 hsa-miR-455-5p BCL2 -0.196032525410701 0.627038966906064 -0.330211405493396 0.555031371665433 mirMAP -0.409582744430861 1.37477678088678e-22 hsa-miR-34c-3p CYCS 0.130155071459505 0.516764839177917 -0.018529217621003 0.976027349211284 mirMAP -0.0632985151736425 0.000264228832902413 hsa-miR-495-3p CYCS -0.159204559213757 0.555240058524588 -0.018529217621003 0.976027349211284 mirMAP -0.103209359396361 2.73071281717473e-09 hsa-miR-340-5p TNFRSF10D 0.0820090452273905 0.816484190854532 -0.162621844415897 0.456246821319228 mirMAP -0.149104609865255 0.00305502578450019 hsa-miR-7-1-3p TNFRSF10D -0.0332815306858167 0.935725386085843 -0.162621844415897 0.456246821319228 mirMAP -0.366697147958665 1.25437324946942e-18 hsa-miR-182-5p PRKX -0.101509746042318 0.939206381321837 -0.16691261365817 0.713645814762555 mirMAP -0.175194994974604 2.67502751484288e-08 hsa-miR-29b-3p PRKX -0.147629200668355 0.855068431567557 -0.16691261365817 0.713645814762555 mirMAP -0.120330213613139 0.0037387071410825 hsa-miR-29c-3p PRKX -0.0526710652467877 0.956320854458284 -0.16691261365817 0.713645814762555 mirMAP -0.38827959473025 7.47361121556913e-23 hsa-miR-625-3p PRKX -0.00228224713043801 0.997356315686925 -0.16691261365817 0.713645814762555 mirMAP -0.146145038207053 0.00114969241015916 hsa-miR-96-5p PRKX -0.153312892459014 0.726115467443483 -0.16691261365817 0.713645814762555 mirMAP -0.0881547950946653 0.00079894964726611 hsa-miR-149-5p IRAK1 0.110896382194027 0.854013616827913 0.00183544026223181 0.997658765903688 mirMAP -0.101659491414051 7.46121484589551e-11 hsa-miR-625-5p PRKAR1B -0.121097781227008 0.486746151168725 0.112247181774356 0.731436264308265 mirMAP -0.108203525336462 5.55805043371063e-05 hsa-miR-342-3p PRKAR1B -0.244092268513731 0.741215180994683 0.112247181774356 0.731436264308265 mirMAP -0.112544514120357 7.06519559214984e-06 hsa-miR-16-1-3p IL1RAP -0.172993537212073 0.391863504419512 -0.142375836605543 0.647003549805492 mirMAP -0.1127844883818 0.00146965071147975 hsa-miR-374a-3p IRAK4 -0.0781632437076389 0.926379383884834 -0.0360699407716556 0.931282088348435 mirMAP -0.065574740235591 0.00144966565601487 hsa-miR-340-5p PPP3R1 0.0820090452273905 0.816484190854532 -0.0271826487262787 0.962679518571233 mirMAP -0.0619721457875075 0.00037248177045784 hsa-miR-32-5p PRKAR2B -0.218686304292785 0.59094441655546 -0.0554605800632748 0.917605527457847 miRNATAP -0.298798035399556 1.17712386857873e-09 hsa-let-7b-5p AIFM1 -0.199052001138817 0.878277241542979 0.125157247739673 0.810026159590102 miRNATAP -0.196110440452601 7.42233386438707e-19 hsa-let-7b-5p BCL2L1 -0.199052001138817 0.878277241542979 0.150447773019176 0.810155517148199 miRNATAP -0.0550286507867917 0.00702265788085669 hsa-let-7b-5p FASLG -0.199052001138817 0.878277241542979 -0.202775932032809 0.329163605225123 miRNATAP -0.244673453612857 0.000244706869361269 hsa-miR-30a-5p CASP3 -0.315304933842571 0.81611555406281 -0.00895575799140413 0.985101397582454 miRNATAP -0.146653827176832 2.4661703600601e-29 hsa-miR-96-5p PRKACB -0.153312892459014 0.726115467443483 -0.0742837105484302 0.886731753016865 miRNATAP -0.0911062171827352 0.00250648512206787 hsa-miR-20b-5p AKT3 -0.275771697228234 0.506979861341138 -0.10604090651417 0.811944436836746 miRNATAP -0.054292387071714 0.0268652636152707 hsa-miR-20b-5p PPP3CA -0.275771697228234 0.506979861341138 -0.078895894384611 0.886413963353503 miRNATAP -0.0563413508601391 0.000470296550304845 hsa-miR-106b-5p XIAP -0.0853499657102335 0.901700669947609 -0.0212306078731803 0.970140712022331 miRNATAP -0.164399803151626 1.10885313299606e-18 hsa-miR-106b-5p PPP3CA -0.0853499657102335 0.901700669947609 -0.078895894384611 0.886413963353503 miRNATAP -0.163746270795427 4.48730421523751e-08 hsa-miR-106b-5p AKT3 -0.0853499657102335 0.901700669947609 -0.10604090651417 0.811944436836746 miRNATAP -0.328917679851073 3.2761525214021e-13 hsa-miR-30b-5p PIK3R2 -0.126278303055191 0.871574517121767 0.0188890891833005 0.974660326807292 miRNATAP -0.111541133552651 3.5447180691879e-06 hsa-miR-93-5p AKT3 0.0554251653547535 0.959380932710413 -0.10604090651417 0.811944436836746 miRNATAP -0.358774978428685 5.45504344144073e-16 hsa-miR-93-5p PPP3CA 0.0554251653547535 0.959380932710413 -0.078895894384611 0.886413963353503 miRNATAP -0.162948227314112 3.15959129159339e-08 hsa-miR-200a-3p PPP3R1 -0.192839143060886 0.77994979695622 -0.0271826487262787 0.962679518571233 miRNATAP -0.0631015819573042 2.5955329177943e-09 hsa-miR-502-3p APAF1 -0.112324660408878 0.668115269202166 -0.0751479999846154 0.860066851482364 miRNATAP -0.0689058625183242 0.00142146567558828 hsa-miR-18a-5p PRKACB -0.060215066151506 0.836155187457355 -0.0742837105484302 0.886731753016865 miRNATAP -0.109828861303179 0.000270889162356874 hsa-miR-101-3p PPP3R1 -0.140525462772132 0.906382304639665 -0.0271826487262787 0.962679518571233 miRNATAP -0.187171459954337 1.17776284425277e-17 hsa-miR-3065-3p PPP3CA 0.22426467087409 0.627407590125411 -0.078895894384611 0.886413963353503 miRNATAP -0.0743114376451225 1.50224279542979e-05 hsa-miR-181b-5p AKT3 0.0375130667115933 0.959555096276237 -0.10604090651417 0.811944436836746 miRNATAP -0.228362092376509 5.2632904676588e-08 hsa-miR-29b-3p AKT3 -0.147629200668355 0.855068431567557 -0.10604090651417 0.811944436836746 miRNATAP -0.240095261108435 6.25012390753699e-08 hsa-miR-324-3p TRADD -0.0533960575545418 0.892365633037602 0.125409014371577 0.7338485707446 miRNATAP -0.176248272366902 1.15041896326237e-09 hsa-miR-26a-5p PIK3R3 -0.0558466394626773 0.953979749143751 -0.219842654525774 0.727127805779104 miRNATAP -0.28216506702381 5.37056936747542e-11 hsa-miR-214-3p PIK3CB -0.110449829460212 0.670567263185672 0.00273687598475192 0.995821179568198 miRNATAP -0.0925669237935847 1.20285804171532e-09 hsa-miR-21-5p PPP3CA 0.0148493782366828 0.992419670576308 -0.078895894384611 0.886413963353503 miRNATAP -0.171857455775929 3.70280677648987e-09 hsa-miR-145-5p AIFM1 -0.100454390360341 0.915532001568304 0.125157247739673 0.810026159590102 miRNATAP -0.134460530608588 6.48751185465965e-19 hsa-miR-30d-5p PIK3R2 0.00512174341017158 0.996390931509314 0.0188890891833005 0.974660326807292 miRNATAP -0.135541098242265 1.30568664423737e-05 hsa-miR-92b-3p PRKAR2B -0.0975289498867111 0.871999313512183 -0.0554605800632748 0.917605527457847 miRNATAP -0.28511576575796 1.35261141577019e-10 hsa-miR-92b-3p PRKAR1B -0.0975289498867111 0.871999313512183 0.112247181774356 0.731436264308265 miRNATAP -0.152761919500563 1.27937973337764e-08 hsa-miR-200c-3p PRKAR2B -0.0449560636499466 0.969433069399071 -0.0554605800632748 0.917605527457847 miRNATAP -0.292941274401131 8.32765818000856e-14 hsa-miR-17-3p AKT3 -0.00462206849027691 0.994608252674318 -0.10604090651417 0.811944436836746 miRNATAP -0.104678278354161 0.0116605571471321 hsa-miR-20a-5p XIAP 0.0648697217907399 0.924634007033878 -0.0212306078731803 0.970140712022331 miRNATAP -0.200905990933434 3.22421053196709e-42 hsa-miR-20a-5p PPP3CA 0.0648697217907399 0.924634007033878 -0.078895894384611 0.886413963353503 miRNATAP -0.110326267376209 6.81988772591416e-06 hsa-miR-20a-5p AKT3 0.0648697217907399 0.924634007033878 -0.10604090651417 0.811944436836746 miRNATAP -0.142287905559561 0.000137185408492637 hsa-let-7i-5p AIFM1 -0.0150044050672964 0.984758993703736 0.125157247739673 0.810026159590102 miRNATAP -0.263687322690925 2.18002823821379e-12 hsa-let-7i-5p BCL2L1 -0.0150044050672964 0.984758993703736 0.150447773019176 0.810155517148199 miRNATAP -0.321772345664847 8.06744439816135e-22 hsa-miR-654-3p TNF -0.187928566892617 0.631807992098329 -0.585975280957927 0.00235534467531092 miRNATAP -0.0898613497311195 0.032614161742769 hsa-miR-429 MAP3K14 -0.142589289838583 0.802317907773415 -0.12414810023034 0.758808723687369 miRNATAP -0.0516575810638598 0.00107724701894735 hsa-miR-15b-5p AKT3 0.0382341477298391 0.953925647243518 -0.10604090651417 0.811944436836746 miRNATAP -0.193152993862959 3.52162993117826e-06 hsa-let-7f-5p PPP3CA -0.052676842774197 0.963441505261455 -0.078895894384611 0.886413963353503 miRNATAP -0.102194254433793 0.00165189815382032 hsa-let-7d-5p BCL2L1 -0.176960380407253 0.795858406343421 0.150447773019176 0.810155517148199 miRNATAP -0.0988191911171127 1.26410841506125e-05 hsa-miR-340-5p NFKB1 0.0820090452273905 0.816484190854532 -0.182686900068147 0.740893021200228 miRNATAP -0.0970580036396175 2.31396408277229e-07 hsa-miR-181c-5p AKT3 -0.18121298802215 0.718350072627076 -0.10604090651417 0.811944436836746 miRNATAP -0.0918531283098773 0.0324898607977673 hsa-miR-369-3p IKBKB -0.0734607425694875 0.755351791463265 0.0975605327133957 0.86231928668593 miRNATAP -0.095146272328477 0.000105332463771023 hsa-miR-27a-3p XIAP -0.0713791016390708 0.936296470694396 -0.0212306078731803 0.970140712022331 miRNATAP -0.146521380961922 8.74015744954972e-11 hsa-miR-27a-3p APAF1 -0.0713791016390708 0.936296470694396 -0.0751479999846154 0.860066851482364 miRNATAP -0.119009261831353 2.41438306531375e-06 hsa-miR-185-5p PIK3R1 0.0659414824247602 0.896134370932431 -0.161573746542345 0.805057044088694 miRNATAP -0.576307293918371 1.92791131730155e-28 hsa-miR-9-5p PRKAR2B 0.513826958284847 0.574325590140814 -0.0554605800632748 0.917605527457847 miRNATAP -0.123752557077492 1.86061068432454e-07 hsa-miR-182-5p PRKAR1A -0.101509746042318 0.939206381321837 0.0481949802694981 0.9487025470248 miRNATAP -0.0516413454081783 0.00288284329912353 hsa-miR-182-5p PIK3R1 -0.101509746042318 0.939206381321837 -0.161573746542345 0.805057044088694 miRNATAP -0.209986504782115 4.31661758321545e-12 hsa-miR-30c-5p CASP3 -0.268052278300344 0.753220585849573 -0.00895575799140413 0.985101397582454 miRNATAP -0.111784978428745 4.21945016044375e-08 hsa-miR-455-5p PIK3CB -0.196032525410701 0.627038966906064 0.00273687598475192 0.995821179568198 miRNATAP -0.0975797797596625 7.16793379852956e-10 hsa-miR-29a-3p PIK3CB -0.173904473376583 0.873886834369773 0.00273687598475192 0.995821179568198 miRNATAP -0.081009719360675 0.00035572222630254 hsa-miR-15a-5p PPP3CB 0.027476192963463 0.965257307327948 0.0212980346837259 0.969289216388387 miRNATAP -0.126089090631579 8.14069089424982e-09 hsa-miR-125b-5p AIFM1 -0.0598851546678105 0.945288350565791 0.125157247739673 0.810026159590102 miRNATAP -0.202683534719948 3.65034871714343e-33 hsa-let-7e-5p FASLG 0.0357092208790988 0.968612511131967 -0.202775932032809 0.329163605225123 miRNATAP -0.337100053640702 2.69864596660333e-05 hsa-miR-181a-5p AKT3 0.0637093750406734 0.945876131429707 -0.10604090651417 0.811944436836746 miRNATAP -0.151700435123375 0.00241569058552761 hsa-miR-320b PIK3R1 -0.0203395214664157 0.930562048282019 -0.161573746542345 0.805057044088694 miRNATAP -0.140552558146201 5.57745902628767e-05 hsa-miR-505-5p BCL2L1 -0.119032738073989 0.680147623619206 0.150447773019176 0.810155517148199 miRNATAP -0.108734867438394 1.06030624737444e-14 hsa-miR-107 PPP3R1 -0.00374429919903285 0.994322461958742 -0.0271826487262787 0.962679518571233 miRNATAP -0.0636818082655454 0.00542700155076685 hsa-miR-27b-3p XIAP -0.113933322553999 0.889976675583125 -0.0212306078731803 0.970140712022331 miRNATAP -0.137918346860995 4.71201482825092e-11 hsa-miR-27b-3p APAF1 -0.113933322553999 0.889976675583125 -0.0751479999846154 0.860066851482364 miRNATAP -0.0910743930509787 0.000105078962254432 hsa-miR-1976 AKT2 -0.190354496295963 0.520771411809134 0.0504008323501575 0.936738544702785 miRNATAP -0.0509043763490527 0.0289757581203213