miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-101-3p AKT3 0.522819989585461 0.00375627731618038 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.334857831597034 0.000597756240419548 NA NA NA hsa-miR-106a-5p AKT3 2.48882002962836 1.99757727374521e-12 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.236478824223264 6.56988295029948e-07 NA NA NA hsa-miR-106b-5p AKT3 2.46782146831112 1.36171495805632e-23 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.521755012930227 1.0756262414999e-15 NA NA NA hsa-miR-107 AKT3 1.30977326593435 1.30372468603965e-11 -1.94162990884529 4.54380296394505e-08 PITA;miRanda -0.438321009170574 6.41595199298462e-07 NA NA NA hsa-miR-15a-5p AKT3 2.34669284378787 1.69544424500258e-23 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.653282073492048 2.38693369892811e-22 NA NA NA hsa-miR-15b-5p AKT3 1.57112623124278 9.14247846750597e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.4862313443712 1.80429141906685e-10 NA NA NA hsa-miR-16-5p AKT3 1.75824877145857 1.68592440033108e-16 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.527819854451446 1.06852141480407e-11 NA NA NA hsa-miR-17-3p AKT3 2.2704817679209 1.1667437320211e-22 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.393678889428456 2.72155279297878e-08 NA NA NA hsa-miR-17-5p AKT3 3.2710598467455 9.93128340539455e-27 -1.94162990884529 4.54380296394505e-08 TargetScan;miRNATAP -0.385876321416217 1.42856705542315e-13 NA NA NA hsa-miR-181a-5p AKT3 2.29556023480783 1.8138457900616e-21 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.283343247743329 3.77571043690309e-05 NA NA NA hsa-miR-181b-5p AKT3 2.49307679431293 3.92829250217627e-20 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.273550202394616 7.65012329836386e-06 NA NA NA hsa-miR-181c-5p AKT3 1.58587920618301 1.57506918816933e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.234902996176996 0.000670085449584041 NA NA NA hsa-miR-20a-5p AKT3 3.15577933619191 4.19753346442454e-25 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.397380097014522 3.56434655429537e-14 NA NA NA hsa-miR-20b-5p AKT3 2.07706563022469 1.10107236083433e-05 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.159136097484426 1.15057100055016e-05 NA NA NA hsa-miR-22-3p AKT3 1.21545661147757 1.61670170137775e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.356198759053997 0.000637369773108939 NA NA NA hsa-miR-29b-2-5p AKT3 0.910668640983475 0.00666655585493488 -1.94162990884529 4.54380296394505e-08 mirMAP -0.413342005890553 1.74596670459023e-16 NA NA NA hsa-miR-29b-3p AKT3 1.65828197923813 1.02676780888141e-09 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.328715384299769 1.41956551647306e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-29c-3p AKT3 -0.00968972577705429 0.97099586346872 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRNATAP -0.256484648428124 9.16722320814547e-05 NA NA NA hsa-miR-3065-5p AKT3 2.74629919868982 1.86846589298284e-08 -1.94162990884529 4.54380296394505e-08 mirMAP -0.196776388311872 4.09483787014971e-06 NA NA NA hsa-miR-32-3p AKT3 2.02436999565685 5.94091197945307e-09 -1.94162990884529 4.54380296394505e-08 mirMAP -0.274043726011417 8.75730973684685e-07 NA NA NA hsa-miR-320a AKT3 0.438165828017084 0.0390159073347133 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.539139659729602 3.01448987258332e-11 NA NA NA hsa-miR-320b AKT3 1.55692969039548 1.41071034251915e-08 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.376164976249955 1.04134326075959e-09 NA NA NA hsa-miR-335-3p AKT3 3.08791651139852 5.31309869723517e-12 -1.94162990884529 4.54380296394505e-08 mirMAP -0.222130607012057 2.63416728864213e-09 NA NA NA hsa-miR-33a-3p AKT3 1.72765312072219 1.51784443453521e-07 -1.94162990884529 4.54380296394505e-08 mirMAP -0.325733544419159 9.28241682908522e-09 NA NA NA hsa-miR-362-3p AKT3 2.0756816987665 3.89026064579331e-12 -1.94162990884529 4.54380296394505e-08 miRanda -0.16536843343699 0.0049777492806053 NA NA NA hsa-miR-362-5p AKT3 1.59303749908759 9.582675908797e-08 -1.94162990884529 4.54380296394505e-08 PITA;TargetScan;miRNATAP -0.201169258976553 0.000472996311050305 NA NA NA hsa-miR-374a-5p AKT3 0.484615721953736 0.0042981729815149 -1.94162990884529 4.54380296394505e-08 mirMAP -0.289501808595266 0.00547104114009117 NA NA NA hsa-miR-421 AKT3 1.17791565395543 6.78526676976629e-06 -1.94162990884529 4.54380296394505e-08 miRanda;mirMAP -0.270003673244585 4.40560995362011e-05 NA NA NA hsa-miR-501-3p AKT3 1.83132758513743 1.10971547702065e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.357094776714992 1.69773165528929e-09 NA NA NA hsa-miR-502-3p AKT3 1.50560877085049 1.2647489756373e-11 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.326505295822604 2.04961437337709e-05 NA NA NA hsa-miR-505-3p AKT3 1.45322244209148 8.86597629645867e-10 -1.94162990884529 4.54380296394505e-08 mirMAP -0.409352554521824 1.03207996907079e-08 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-769-5p AKT3 1.82023760596845 9.6815886564134e-14 -1.94162990884529 4.54380296394505e-08 PITA;miRNATAP -0.445071301297515 6.71512496875401e-11 NA NA NA hsa-miR-93-5p AKT3 3.03961860136032 1.11672209617395e-24 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.494281511913237 1.38435165024812e-20 NA NA NA hsa-miR-146b-5p BRAF 1.75587235896724 1.15724631266659e-07 -0.0380624164019494 0.839544086141468 miRanda -0.146633871679738 3.64395605099119e-08 21874046;26883911;20406109;21537871 Additionally the activation of thyroid most common oncogenes RET/PTC3 and BRAF in PCCL3 cells upregulated miR-146b-5p expression;miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells independently from their original mutation either BRAF or RET/PTC through a mechanism that involves the actin cytoskeleton but not an increased capacity of matrix degradation;The miR-146b expression levels in PTCs with BRAF mutation were significantly higher than those without this mutation p < 0.0001;Among BRAF-positive tumors overexpression of miR-146b was associated with aggressive behavior suggesting that it may further refine the prognostic importance of BRAF ;;; thyroid cancer;thyroid cancer;thyroid cancer;thyroid cancer hsa-miR-199a-5p BRAF 0.592984035153911 0.0674836634175293 -0.0380624164019494 0.839544086141468 miRanda -0.100551330747605 0.000311009640639109 NA NA NA hsa-miR-103a-3p CAB39 1.44083190496858 1.53799939616416e-13 -0.477158523544161 0.00138539746274052 MirTarget;miRNATAP -0.172743294933037 1.59792620328537e-06 NA NA NA hsa-miR-151a-3p CAB39 1.24018761527407 1.08839919675408e-07 -0.477158523544161 0.00138539746274052 MirTarget -0.108706219270977 0.000381713653378672 NA NA NA hsa-miR-320a CAB39 0.438165828017084 0.0390159073347133 -0.477158523544161 0.00138539746274052 MirTarget;PITA;miRanda;miRNATAP -0.143026874546394 2.76474182066111e-05 NA NA NA hsa-miR-425-5p CAB39 3.07071373939774 4.02947460586085e-25 -0.477158523544161 0.00138539746274052 MirTarget -0.113641248897846 5.96290649580998e-07 NA NA NA hsa-miR-155-5p CAB39L 1.20164021433135 0.00086170622431261 -1.32713099101099 0.0016286153077432 miRNAWalker2_validate -0.465068952849233 1.19895211489865e-17 NA NA NA hsa-miR-214-5p CAB39L 0.962365243662358 0.0069147776948866 -1.32713099101099 0.0016286153077432 MirTarget -0.199486122647592 0.000482891477634037 NA NA NA hsa-miR-342-3p CAB39L 1.49115144672245 1.43879249744621e-07 -1.32713099101099 0.0016286153077432 miRanda -0.345811625519967 9.98604734821319e-07 NA NA NA hsa-miR-362-3p CAB39L 2.0756816987665 3.89026064579331e-12 -1.32713099101099 0.0016286153077432 miRanda -0.233526737377569 0.000701131740966757 NA NA NA hsa-miR-539-5p CAB39L 0.95216780650456 0.00284373332122135 -1.32713099101099 0.0016286153077432 mirMAP -0.156191725914134 0.0154148730579171 NA NA NA hsa-miR-590-3p CAB39L 2.59289455139753 1.03200520972022e-21 -1.32713099101099 0.0016286153077432 miRanda -0.271432757362025 0.000233995683821118 NA NA NA hsa-miR-590-5p CAB39L 3.18300989862077 2.06813568597893e-26 -1.32713099101099 0.0016286153077432 miRanda -0.216240907453537 0.00104450011172972 NA NA NA hsa-miR-7-1-3p CAB39L 1.84950311431067 1.25300363397654e-13 -1.32713099101099 0.0016286153077432 mirMAP -0.346297894182823 1.3001850315113e-05 NA NA NA hsa-miR-101-3p DDIT4 0.522819989585461 0.00375627731618038 0.717938757137077 0.0430461225180125 miRNAWalker2_validate;MirTarget;miRNATAP -0.355155844720243 0.00021315858646136 NA NA NA hsa-miR-181c-5p DDIT4 1.58587920618301 1.57506918816933e-10 0.717938757137077 0.0430461225180125 MirTarget -0.145077871296069 0.0335547857337937 NA NA NA hsa-miR-181d-5p DDIT4 1.52204912185579 9.2693319057748e-08 0.717938757137077 0.0430461225180125 MirTarget -0.127310279952917 0.0330653294977689 NA NA NA hsa-miR-30b-5p DDIT4 0.800822374912712 0.000133601914525413 0.717938757137077 0.0430461225180125 MirTarget -0.231516620607933 0.00481015325205432 NA NA NA hsa-miR-30c-5p DDIT4 0.778774633108 0.000285599212429136 0.717938757137077 0.0430461225180125 MirTarget;miRNATAP -0.189580566588003 0.0182756104343371 NA NA NA hsa-miR-30d-5p DDIT4 0.675423997639582 0.00270618816039773 0.717938757137077 0.0430461225180125 MirTarget;miRNATAP -0.233442309312649 0.00227699320721357 NA NA NA hsa-miR-30e-5p DDIT4 1.23904909539663 1.35561917122157e-09 0.717938757137077 0.0430461225180125 MirTarget -0.279318696597116 0.000764635783021267 NA NA NA hsa-miR-32-5p DDIT4 2.34056473219422 6.24134585974322e-20 0.717938757137077 0.0430461225180125 miRNATAP -0.250841298923405 8.90809727205639e-05 NA NA NA hsa-miR-103a-3p EIF4B 1.44083190496858 1.53799939616416e-13 -0.83546386425099 1.60081741236658e-10 MirTarget;miRNATAP -0.12384012181884 0.000120527401673825 NA NA NA hsa-miR-107 EIF4B 1.30977326593435 1.30372468603965e-11 -0.83546386425099 1.60081741236658e-10 MirTarget;PITA;miRanda;miRNATAP -0.116267081967539 0.000376104753401664 NA NA NA hsa-miR-15a-5p EIF4B 2.34669284378787 1.69544424500258e-23 -0.83546386425099 1.60081741236658e-10 miRNATAP -0.115102898094679 8.58712735181583e-06 NA NA NA hsa-miR-15b-5p EIF4B 1.57112623124278 9.14247846750597e-13 -0.83546386425099 1.60081741236658e-10 miRNATAP -0.108417564399088 0.000145863770523161 NA NA NA hsa-miR-16-5p EIF4B 1.75824877145857 1.68592440033108e-16 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.116626867681087 6.27326636466319e-05 NA NA NA hsa-miR-185-5p EIF4B 2.34016206907488 1.17481626642022e-26 -0.83546386425099 1.60081741236658e-10 MirTarget -0.163628340278415 2.05665506314812e-09 NA NA NA hsa-miR-193a-3p EIF4B 1.60460546928078 2.86169793322984e-07 -0.83546386425099 1.60081741236658e-10 miRanda -0.129748653727289 7.39065685686338e-11 NA NA NA hsa-miR-193b-3p EIF4B 2.25711804611899 4.1940744806631e-14 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.131575191324763 1.39505544343809e-10 NA NA NA hsa-miR-25-3p EIF4B 1.36472605225697 4.83790725935681e-11 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.106392733880944 0.000481532722887453 NA NA NA hsa-miR-342-3p EIF4B 1.49115144672245 1.43879249744621e-07 -0.83546386425099 1.60081741236658e-10 miRanda -0.126332356229928 1.1049251414087e-08 NA NA NA hsa-miR-362-3p EIF4B 2.0756816987665 3.89026064579331e-12 -0.83546386425099 1.60081741236658e-10 miRanda -0.161499044149002 1.7968030077065e-14 NA NA NA hsa-miR-423-3p EIF4B 2.57855385753676 9.19765570228097e-24 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.131931378309889 1.88384562098769e-08 NA NA NA hsa-miR-424-5p EIF4B 1.61930224569578 1.89642549274994e-10 -0.83546386425099 1.60081741236658e-10 miRNATAP -0.129745405637866 1.30304622694912e-07 NA NA NA hsa-miR-484 EIF4B 1.81844463411787 1.82951571230938e-15 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.115522506643854 2.13739109619376e-05 NA NA NA hsa-miR-532-3p EIF4B 1.96631878320218 4.53421954361695e-13 -0.83546386425099 1.60081741236658e-10 miRNATAP -0.138783439415054 9.6358571664864e-10 NA NA NA hsa-miR-590-3p EIF4B 2.59289455139753 1.03200520972022e-21 -0.83546386425099 1.60081741236658e-10 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.10810967510776 2.80808517421654e-06 NA NA NA hsa-miR-106b-3p HIF1A 1.74115042407425 7.96524575137272e-14 -0.0887083952652183 0.694448347585856 miRNAWalker2_validate -0.115876573349366 0.01114041942823 NA NA NA hsa-miR-106b-5p HIF1A 2.46782146831112 1.36171495805632e-23 -0.0887083952652183 0.694448347585856 MirTarget -0.22506470406352 5.67731754915871e-08 NA NA NA hsa-miR-107 HIF1A 1.30977326593435 1.30372468603965e-11 -0.0887083952652183 0.694448347585856 miRNAWalker2_validate;miRTarBase;miRanda -0.123422589068387 0.0264755744668062 NA NA NA hsa-miR-151a-3p HIF1A 1.24018761527407 1.08839919675408e-07 -0.0887083952652183 0.694448347585856 MirTarget -0.16533909856988 0.000338305910074446 NA NA NA hsa-miR-20a-5p HIF1A 3.15577933619191 4.19753346442454e-25 -0.0887083952652183 0.694448347585856 miRNAWalker2_validate;miRTarBase;MirTarget -0.115406855575695 0.000600547799598935 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-28-5p HIF1A 0.230152919654905 0.0742909586754846 -0.0887083952652183 0.694448347585856 miRanda -0.410823482574077 2.0450455286232e-06 NA NA NA hsa-miR-330-3p HIF1A 0.876747334239085 0.00073709016089703 -0.0887083952652183 0.694448347585856 MirTarget;PITA -0.100136266436928 0.0170482873133228 NA NA NA hsa-miR-361-5p HIF1A 0.971859117235239 5.30236555707088e-09 -0.0887083952652183 0.694448347585856 miRanda -0.240248110278126 0.00022502129165918 NA NA NA hsa-miR-660-5p HIF1A 1.82692095272076 1.92040083607196e-13 -0.0887083952652183 0.694448347585856 MirTarget -0.138381785632354 0.00119715434144136 NA NA NA hsa-miR-93-5p HIF1A 3.03961860136032 1.11672209617395e-24 -0.0887083952652183 0.694448347585856 MirTarget -0.194707893705988 1.28811205175096e-08 NA NA NA hsa-let-7a-3p IGF1 1.42015538786275 7.03375209382654e-13 -3.75951127345565 1.26264890381366e-10 mirMAP -0.92426917804667 5.0725450948492e-11 NA NA NA hsa-let-7a-5p IGF1 0.618599506841644 2.76973453058748e-05 -3.75951127345565 1.26264890381366e-10 TargetScan -1.35484578107079 3.03432417502265e-12 NA NA NA hsa-let-7b-3p IGF1 0.868207752019623 1.30460056774366e-05 -3.75951127345565 1.26264890381366e-10 mirMAP -0.806527950481254 1.86996353532323e-08 NA NA NA hsa-let-7f-1-3p IGF1 1.55054488387679 7.31326775537952e-11 -3.75951127345565 1.26264890381366e-10 mirMAP -0.53583367534408 1.14955943868674e-05 NA NA NA hsa-miR-103a-2-5p IGF1 2.47599305985086 7.933028987326e-11 -3.75951127345565 1.26264890381366e-10 mirMAP -0.672288935268143 1.21134250789966e-16 NA NA NA hsa-miR-129-5p IGF1 -0.524170159980738 0.222582956006346 -3.75951127345565 1.26264890381366e-10 MirTarget;PITA;miRanda -0.24872412851026 0.000279350666200339 NA NA NA hsa-miR-130a-3p IGF1 2.02021855058359 1.26427102520415e-11 -3.75951127345565 1.26264890381366e-10 MirTarget -0.315325422858442 0.000861190344159203 NA NA NA hsa-miR-130b-3p IGF1 3.5350292994509 1.73934183852569e-27 -3.75951127345565 1.26264890381366e-10 MirTarget -0.781941096991651 4.63853079450254e-23 NA NA NA hsa-miR-148a-5p IGF1 1.16173838132242 0.000148929299881612 -3.75951127345565 1.26264890381366e-10 mirMAP -0.212992981754178 0.0236997428556886 NA NA NA hsa-miR-15b-3p IGF1 2.33847028227712 4.29662877950836e-19 -3.75951127345565 1.26264890381366e-10 mirMAP -1.14217010288885 5.28861971423639e-31 NA NA NA hsa-miR-16-1-3p IGF1 2.56983217111073 3.02262181237943e-20 -3.75951127345565 1.26264890381366e-10 mirMAP -0.921958602704484 2.5787665170735e-21 NA NA NA hsa-miR-181a-5p IGF1 2.29556023480783 1.8138457900616e-21 -3.75951127345565 1.26264890381366e-10 mirMAP -0.642043297035051 1.32592036628183e-08 NA NA NA hsa-miR-181b-5p IGF1 2.49307679431293 3.92829250217627e-20 -3.75951127345565 1.26264890381366e-10 mirMAP -0.697159274066391 2.64064192584975e-12 NA NA NA hsa-miR-181c-5p IGF1 1.58587920618301 1.57506918816933e-10 -3.75951127345565 1.26264890381366e-10 mirMAP -0.418006737238249 0.00025755851863695 NA NA NA hsa-miR-186-5p IGF1 1.47445398888668 3.0781726595413e-15 -3.75951127345565 1.26264890381366e-10 mirMAP -1.20504446214237 1.61828209547411e-16 NA NA NA hsa-miR-19a-3p IGF1 3.42309334186656 3.02671914353412e-28 -3.75951127345565 1.26264890381366e-10 MirTarget -0.788529625251502 2.31580352219079e-21 NA NA NA hsa-miR-19b-1-5p IGF1 2.57951428759379 4.31576118703427e-20 -3.75951127345565 1.26264890381366e-10 mirMAP -0.995592930242643 1.89907484758614e-25 NA NA NA hsa-miR-19b-3p IGF1 2.49529833021187 1.57028265846699e-23 -3.75951127345565 1.26264890381366e-10 MirTarget -1.0369004238185 3.24569264936101e-23 NA NA NA hsa-miR-20a-3p IGF1 2.92621109947706 2.49504904635375e-17 -3.75951127345565 1.26264890381366e-10 mirMAP -0.809636638775284 3.3899709447565e-25 NA NA NA hsa-miR-224-3p IGF1 1.87536386559317 6.15140969394846e-05 -3.75951127345565 1.26264890381366e-10 mirMAP -0.362328718988192 1.01049263740062e-08 NA NA NA hsa-miR-26b-5p IGF1 0.885393662798425 3.2116297961629e-06 -3.75951127345565 1.26264890381366e-10 mirMAP -0.940665920848216 3.14292070875382e-10 NA NA NA hsa-miR-27a-3p IGF1 1.66542180327138 4.93775737894805e-13 -3.75951127345565 1.26264890381366e-10 miRNAWalker2_validate;miRTarBase -0.651692554274928 7.73576562076687e-08 NA NA NA hsa-miR-29b-3p IGF1 1.65828197923813 1.02676780888141e-09 -3.75951127345565 1.26264890381366e-10 MirTarget -0.519110555190393 5.59140789276621e-07 25592039 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 IGF1 3' untranslated region 3'UTR; IGF1 an activator of PI3K/Akt signaling was confirmed as a novel target of miR-29b colorectal cancer hsa-miR-301a-3p IGF1 2.81024345929638 2.29784847962242e-17 -3.75951127345565 1.26264890381366e-10 MirTarget -0.801898835472881 2.70419582744703e-21 NA NA NA hsa-miR-3065-5p IGF1 2.74629919868982 1.86846589298284e-08 -3.75951127345565 1.26264890381366e-10 mirMAP -0.340906479396581 1.44245852597366e-06 NA NA NA hsa-miR-32-3p IGF1 2.02436999565685 5.94091197945307e-09 -3.75951127345565 1.26264890381366e-10 mirMAP -0.670318737511073 1.52748719371215e-13 NA NA NA hsa-miR-320a IGF1 0.438165828017084 0.0390159073347133 -3.75951127345565 1.26264890381366e-10 miRNATAP -0.87110280497324 9.95766777508728e-11 NA NA NA hsa-miR-320b IGF1 1.55692969039548 1.41071034251915e-08 -3.75951127345565 1.26264890381366e-10 miRNATAP -0.993279990978514 6.22780218264885e-24 NA NA NA hsa-miR-33a-3p IGF1 1.72765312072219 1.51784443453521e-07 -3.75951127345565 1.26264890381366e-10 MirTarget -0.862622681654972 2.52525229105421e-21 NA NA NA hsa-miR-3607-3p IGF1 2.68532138541128 5.66716351955047e-14 -3.75951127345565 1.26264890381366e-10 mirMAP -0.646493669321152 1.00233762873621e-16 NA NA NA hsa-miR-361-5p IGF1 0.971859117235239 5.30236555707088e-09 -3.75951127345565 1.26264890381366e-10 PITA;mirMAP -1.48168691679158 5.53863901928066e-19 NA NA NA hsa-miR-374b-3p IGF1 0.930487774873495 2.74420094310516e-05 -3.75951127345565 1.26264890381366e-10 mirMAP -0.498455115159369 0.000129551554566347 NA NA NA hsa-miR-3913-5p IGF1 2.44353493655328 8.95279496632448e-15 -3.75951127345565 1.26264890381366e-10 mirMAP -0.584661382885468 7.3573353974355e-11 NA NA NA hsa-miR-421 IGF1 1.17791565395543 6.78526676976629e-06 -3.75951127345565 1.26264890381366e-10 PITA -0.696572691037999 1.11839961387445e-10 NA NA NA hsa-miR-452-5p IGF1 1.37180058737183 0.00171494843537772 -3.75951127345565 1.26264890381366e-10 MirTarget;mirMAP -0.239891308263067 0.000253591244736158 NA NA NA hsa-miR-454-3p IGF1 2.47234127820054 1.12878018736016e-21 -3.75951127345565 1.26264890381366e-10 MirTarget -0.897384141255581 2.08224455125487e-17 NA NA NA hsa-miR-486-5p IGF1 -0.194913133034028 0.607377798807705 -3.75951127345565 1.26264890381366e-10 PITA;miRNATAP -0.336416232300254 9.17459110593128e-06 NA NA NA hsa-miR-576-5p IGF1 2.20467023993664 3.4053475193793e-19 -3.75951127345565 1.26264890381366e-10 PITA;mirMAP;miRNATAP -1.00551072603292 1.14064166854676e-20 NA NA NA hsa-miR-590-3p IGF1 2.59289455139753 1.03200520972022e-21 -3.75951127345565 1.26264890381366e-10 MirTarget;miRanda;mirMAP;miRNATAP -0.845684857318828 5.27514597787573e-17 NA NA NA hsa-miR-592 IGF1 1.51765968871077 0.000636335248013204 -3.75951127345565 1.26264890381366e-10 mirMAP -0.450455314337535 2.70073065710591e-12 NA NA NA hsa-miR-629-5p IGF1 2.10182419359635 1.51788571125757e-15 -3.75951127345565 1.26264890381366e-10 mirMAP -0.693559501922869 2.74994850835533e-11 NA NA NA hsa-miR-664a-3p IGF1 0.634721925861133 0.00520070178640421 -3.75951127345565 1.26264890381366e-10 mirMAP -0.350873716989665 0.00610206128936229 NA NA NA hsa-miR-940 IGF1 3.21011374578759 2.7923171128495e-14 -3.75951127345565 1.26264890381366e-10 MirTarget;PITA;miRNATAP -0.715084793572266 1.27978685880086e-25 NA NA NA hsa-miR-140-3p MAPK1 0.0608890720479334 0.727716871248724 -0.300413846088826 0.0202503240217449 PITA;miRNATAP -0.126850675206772 0.000457308593536618 NA NA NA hsa-miR-30c-5p MAPK1 0.778774633108 0.000285599212429136 -0.300413846088826 0.0202503240217449 mirMAP -0.161696427374548 1.83237959021178e-08 NA NA NA hsa-miR-30e-5p MAPK1 1.23904909539663 1.35561917122157e-09 -0.300413846088826 0.0202503240217449 mirMAP -0.123981973754552 3.68994437193015e-05 NA NA NA hsa-miR-34a-5p MAPK1 1.9016323452565 1.43092834643601e-14 -0.300413846088826 0.0202503240217449 mirMAP -0.113934200811126 2.89029232507908e-06 NA NA NA hsa-miR-186-5p PDPK1 1.47445398888668 3.0781726595413e-15 -0.446682027133002 0.00835125010618968 mirMAP -0.125708876159213 0.00333632806915964 NA NA NA hsa-miR-22-5p PDPK1 1.88011544159252 1.63978222572222e-16 -0.446682027133002 0.00835125010618968 miRNATAP -0.181020438712566 1.45237356289081e-07 NA NA NA hsa-miR-29b-3p PDPK1 1.65828197923813 1.02676780888141e-09 -0.446682027133002 0.00835125010618968 mirMAP -0.109518325633884 0.000211964623360266 NA NA NA hsa-miR-342-3p PDPK1 1.49115144672245 1.43879249744621e-07 -0.446682027133002 0.00835125010618968 mirMAP -0.109793629457974 0.000113758361154384 NA NA NA hsa-miR-374a-3p PDPK1 0.533309330504947 0.00192918429705142 -0.446682027133002 0.00835125010618968 mirMAP -0.118308754113252 0.0142261349514195 NA NA NA hsa-miR-326 PGF 0.715313016136042 0.0610265683213359 0.82580882918736 0.0169544692696931 mirMAP -0.162219493325868 0.000221458535925083 NA NA NA hsa-miR-421 PGF 1.17791565395543 6.78526676976629e-06 0.82580882918736 0.0169544692696931 miRanda -0.141102218221589 0.0272665155908835 NA NA NA hsa-miR-126-5p PIK3CA 0.895338176458417 2.33372756450713e-05 -0.151828236462886 0.321284398928338 mirMAP -0.103377544898631 0.00298975306098663 NA NA NA hsa-miR-186-5p PIK3CA 1.47445398888668 3.0781726595413e-15 -0.151828236462886 0.321284398928338 mirMAP -0.101671973753504 0.00842161241015832 NA NA NA hsa-miR-320a PIK3CA 0.438165828017084 0.0390159073347133 -0.151828236462886 0.321284398928338 miRanda -0.153857910084833 9.6763748473785e-06 NA NA NA hsa-miR-10b-5p PIK3CD -0.155951595811628 0.555006386998027 -0.775351667927902 0.021645534884375 miRNAWalker2_validate -0.175760207889201 0.004748835358114 NA NA NA hsa-miR-1468-5p PIK3CD 0.0469536064343461 0.881810795145912 -0.775351667927902 0.021645534884375 MirTarget -0.223784917601258 1.49208556354691e-05 NA NA NA hsa-miR-29c-3p PIK3CD -0.00968972577705429 0.97099586346872 -0.775351667927902 0.021645534884375 mirMAP -0.250794863940076 4.41169066967662e-05 NA NA NA hsa-miR-30b-3p PIK3CD 0.834142820354026 0.000972582820878813 -0.775351667927902 0.021645534884375 MirTarget -0.531045557079738 2.22640594160628e-17 NA NA NA hsa-miR-30b-5p PIK3CD 0.800822374912712 0.000133601914525413 -0.775351667927902 0.021645534884375 MirTarget -0.411457344396036 9.99002635635066e-08 NA NA NA hsa-miR-30c-5p PIK3CD 0.778774633108 0.000285599212429136 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.461850084291099 7.5210996634642e-10 NA NA NA hsa-miR-30d-5p PIK3CD 0.675423997639582 0.00270618816039773 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.733785480070449 9.30689014359708e-27 NA NA NA hsa-miR-30e-5p PIK3CD 1.23904909539663 1.35561917122157e-09 -0.775351667927902 0.021645534884375 MirTarget -0.597650735147178 7.00788139486401e-15 NA NA NA hsa-miR-320a PIK3CD 0.438165828017084 0.0390159073347133 -0.775351667927902 0.021645534884375 miRanda -0.437629854617933 1.07773535518864e-08 NA NA NA hsa-miR-320b PIK3CD 1.55692969039548 1.41071034251915e-08 -0.775351667927902 0.021645534884375 miRanda -0.282783919094812 1.19379715607107e-06 NA NA NA hsa-miR-324-5p PIK3CD 2.95683728155095 1.32960514360912e-20 -0.775351667927902 0.021645534884375 miRanda -0.265511883710764 4.30342749668002e-08 NA NA NA hsa-miR-3913-5p PIK3CD 2.44353493655328 8.95279496632448e-15 -0.775351667927902 0.021645534884375 mirMAP -0.395313104822511 3.24743386923115e-15 NA NA NA hsa-miR-421 PIK3CD 1.17791565395543 6.78526676976629e-06 -0.775351667927902 0.021645534884375 miRanda -0.235490163150307 0.000146542275873157 NA NA NA hsa-miR-484 PIK3CD 1.81844463411787 1.82951571230938e-15 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.387158078139352 1.61214627982237e-08 NA NA NA hsa-miR-148b-3p PIK3CG 1.97815018171325 6.07715327281595e-26 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.598035215538084 7.05982657783629e-10 NA NA NA hsa-miR-26b-5p PIK3CG 0.885393662798425 3.2116297961629e-06 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.252635166842034 0.0140326902426817 NA NA NA hsa-miR-335-3p PIK3CG 3.08791651139852 5.31309869723517e-12 -1.04493260087656 0.00941484120426313 mirMAP -0.182751911295676 1.44284270796844e-05 NA NA NA hsa-miR-3607-3p PIK3CG 2.68532138541128 5.66716351955047e-14 -1.04493260087656 0.00941484120426313 mirMAP -0.166734433414221 0.00216182223501734 NA NA NA hsa-miR-421 PIK3CG 1.17791565395543 6.78526676976629e-06 -1.04493260087656 0.00941484120426313 miRanda -0.208294811185602 0.00505346682917229 NA NA NA hsa-miR-590-3p PIK3CG 2.59289455139753 1.03200520972022e-21 -1.04493260087656 0.00941484120426313 miRanda -0.160421801003692 0.0232620908281926 NA NA NA hsa-miR-101-5p PIK3R1 0.782067874775122 0.00443725251526842 -1.16357283690918 1.63774086027679e-06 MirTarget -0.115568250605295 0.00948870207662742 NA NA NA hsa-miR-103a-3p PIK3R1 1.44083190496858 1.53799939616416e-13 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.175702483843164 0.00322284399016944 NA NA NA hsa-miR-106b-5p PIK3R1 2.46782146831112 1.36171495805632e-23 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.24930934707311 3.35624085651532e-08 NA NA NA hsa-miR-107 PIK3R1 1.30977326593435 1.30372468603965e-11 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.201353514049413 0.000854368494298006 NA NA NA hsa-miR-127-5p PIK3R1 1.19850695520181 4.10976607177645e-05 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.164276045731973 4.35688271416755e-05 24004856 Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR 127 in human bladder cancer; These findings provide new insights into the role of miRNAs in the pathway of cancer and give us a hypothesis that miR-127 might play a similar role in regulation and control of PIK3R1 bladder cancer hsa-miR-128-3p PIK3R1 1.63756041666078 6.79626586407187e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.134770050316621 0.0111594593028352 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 2.54959518791507 5.26618591274892e-18 -1.16357283690918 1.63774086027679e-06 MirTarget -0.146009716288673 0.000153002833756534 NA NA NA hsa-miR-132-3p PIK3R1 0.156276992635384 0.408190812100704 -1.16357283690918 1.63774086027679e-06 MirTarget -0.197496588157407 0.00191277589406782 NA NA NA hsa-miR-15a-5p PIK3R1 2.34669284378787 1.69544424500258e-23 -1.16357283690918 1.63774086027679e-06 MirTarget -0.142181030175195 0.00308171212654804 NA NA NA hsa-miR-15b-5p PIK3R1 1.57112623124278 9.14247846750597e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203388250610072 0.000112366544945594 NA NA NA hsa-miR-16-2-3p PIK3R1 2.31623086727196 4.29838149388188e-20 -1.16357283690918 1.63774086027679e-06 MirTarget -0.207543782293348 3.49270114018875e-06 NA NA NA hsa-miR-16-5p PIK3R1 1.75824877145857 1.68592440033108e-16 -1.16357283690918 1.63774086027679e-06 MirTarget -0.20266090985161 0.000166722510489398 NA NA NA hsa-miR-17-5p PIK3R1 3.2710598467455 9.93128340539455e-27 -1.16357283690918 1.63774086027679e-06 MirTarget;TargetScan;miRNATAP -0.194269031204595 7.03363082546611e-08 NA NA NA hsa-miR-185-5p PIK3R1 2.34016206907488 1.17481626642022e-26 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.305558512858305 1.29388513669652e-09 NA NA NA hsa-miR-186-5p PIK3R1 1.47445398888668 3.0781726595413e-15 -1.16357283690918 1.63774086027679e-06 mirMAP -0.274872917366815 8.27585129634137e-06 NA NA NA hsa-miR-188-5p PIK3R1 2.52825126596644 6.78099435999778e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.185661747772095 2.50402606338374e-07 NA NA NA hsa-miR-199a-3p PIK3R1 0.640600337515787 0.0380326905134914 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.156998919927599 4.11373421997523e-05 NA NA NA hsa-miR-199b-3p PIK3R1 0.643923492750702 0.0371742251925406 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.157124307871095 4.00275047495595e-05 NA NA NA hsa-miR-20a-5p PIK3R1 3.15577933619191 4.19753346442454e-25 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.184775072209508 3.70396511881761e-07 NA NA NA hsa-miR-21-5p PIK3R1 2.73773305747971 1.38864982139576e-43 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.344443286817705 1.08270725892964e-10 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.357878936470387 0.232446214501331 -1.16357283690918 1.63774086027679e-06 MirTarget -0.126995222417611 0.00147059810557586 NA NA NA hsa-miR-22-5p PIK3R1 1.88011544159252 1.63978222572222e-16 -1.16357283690918 1.63774086027679e-06 mirMAP -0.292552038138818 3.89552165607854e-09 NA NA NA hsa-miR-221-3p PIK3R1 0.451556679024397 0.0909808299917811 -1.16357283690918 1.63774086027679e-06 MirTarget -0.108240747635063 0.015387314456947 NA NA NA hsa-miR-222-3p PIK3R1 0.851783756239071 0.00266783568486918 -1.16357283690918 1.63774086027679e-06 MirTarget -0.122260306324505 0.00346350093932025 NA NA NA hsa-miR-29a-3p PIK3R1 -0.35074463683376 0.161238718982428 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.197768036084372 3.04095884680599e-05 NA NA NA hsa-miR-29b-3p PIK3R1 1.65828197923813 1.02676780888141e-09 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.226570180742736 9.59427672061032e-08 NA NA NA hsa-miR-3065-5p PIK3R1 2.74629919868982 1.86846589298284e-08 -1.16357283690918 1.63774086027679e-06 MirTarget;mirMAP;miRNATAP -0.121456370441073 3.04699134862982e-05 NA NA NA hsa-miR-369-3p PIK3R1 0.946781510019564 0.00134850306966842 -1.16357283690918 1.63774086027679e-06 PITA -0.165045838001649 3.68847028364345e-05 NA NA NA hsa-miR-409-3p PIK3R1 0.877551657794358 0.00171210686733898 -1.16357283690918 1.63774086027679e-06 mirMAP -0.105859697586648 0.0126015776971144 NA NA NA hsa-miR-424-5p PIK3R1 1.61930224569578 1.89642549274994e-10 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203727044936863 7.79524954848401e-06 NA NA NA hsa-miR-450b-5p PIK3R1 1.69244418548325 1.68064054148881e-10 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.119371689321084 0.0066882062526509 NA NA NA hsa-miR-455-3p PIK3R1 3.06093594997644 3.54590649799868e-16 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.151223028806072 5.34851043578223e-07 NA NA NA hsa-miR-485-3p PIK3R1 0.442820096243914 0.166634696770945 -1.16357283690918 1.63774086027679e-06 mirMAP -0.104228852223792 0.00542492277409986 NA NA NA hsa-miR-493-5p PIK3R1 0.847772103665986 0.00528678068747754 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.141629319654 0.000286613564823519 NA NA NA hsa-miR-532-3p PIK3R1 1.96631878320218 4.53421954361695e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.183574493282594 1.45132602336302e-05 NA NA NA hsa-miR-584-5p PIK3R1 2.7326672683732 9.92677936962233e-12 -1.16357283690918 1.63774086027679e-06 mirMAP -0.136506526285572 1.76178566940588e-06 NA NA NA hsa-miR-589-3p PIK3R1 2.51971841868825 2.39125940264107e-11 -1.16357283690918 1.63774086027679e-06 mirMAP -0.146863008859422 2.43953052082368e-05 NA NA NA hsa-miR-590-3p PIK3R1 2.59289455139753 1.03200520972022e-21 -1.16357283690918 1.63774086027679e-06 miRanda;mirMAP -0.251414695908109 2.6774008322444e-09 NA NA NA hsa-miR-590-5p PIK3R1 3.18300989862077 2.06813568597893e-26 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.233958943001206 5.13569363038349e-10 NA NA NA hsa-miR-629-3p PIK3R1 2.36570947321815 1.33458201201618e-11 -1.16357283690918 1.63774086027679e-06 MirTarget -0.157530213698435 2.37486100403133e-05 NA NA NA hsa-miR-93-5p PIK3R1 3.03961860136032 1.11672209617395e-24 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.155676924698248 3.5347453293642e-05 NA NA NA hsa-miR-96-5p PIK3R1 4.89433085814374 1.92000659886961e-31 -1.16357283690918 1.63774086027679e-06 TargetScan;miRNATAP -0.102966561567807 0.000122371084822612 NA NA NA hsa-miR-1271-5p PIK3R3 0.970418832993172 0.000609742584380688 -0.627704444396048 0.00578594022892978 mirMAP -0.151257171385516 9.56593049733625e-05 NA NA NA hsa-miR-181a-5p PIK3R3 2.29556023480783 1.8138457900616e-21 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.108906602043709 0.0127134423930606 NA NA NA hsa-miR-18a-3p PIK3R3 2.14813400940323 2.23460809936028e-06 -0.627704444396048 0.00578594022892978 miRNAWalker2_validate -0.10342220794232 0.000634896497880219 NA NA NA hsa-miR-19a-3p PIK3R3 3.42309334186656 3.02671914353412e-28 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.120784849374387 0.0002630092907536 NA NA NA hsa-miR-19b-3p PIK3R3 2.49529833021187 1.57028265846699e-23 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.146052627292238 0.000482454548266062 NA NA NA hsa-miR-222-5p PIK3R3 1.25632771414778 0.000138653440511922 -0.627704444396048 0.00578594022892978 mirMAP -0.146201383530692 9.47483044017924e-06 NA NA NA hsa-miR-26b-5p PIK3R3 0.885393662798425 3.2116297961629e-06 -0.627704444396048 0.00578594022892978 miRNATAP -0.184498425433638 0.00145436639404193 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.55384379072167 4.76870585070176e-05 -0.627704444396048 0.00578594022892978 mirMAP -0.182944374912975 8.7655907053222e-10 NA NA NA hsa-miR-365a-3p PIK3R3 -0.0388985816963467 0.859114494267351 -0.627704444396048 0.00578594022892978 MirTarget -0.222976439335601 9.85809729911043e-06 NA NA NA hsa-miR-511-5p PIK3R3 1.04499312543772 0.00234126154508174 -0.627704444396048 0.00578594022892978 MirTarget -0.132527709680848 3.18921565069019e-05 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-92a-3p PIK3R3 2.06460102658973 1.44784291084757e-19 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.185970971603602 5.73870254874264e-05 NA NA NA hsa-miR-107 PIK3R5 1.30977326593435 1.30372468603965e-11 -0.990769658200862 0.00792713202187119 miRanda -0.533513362792699 4.18278914923372e-09 NA NA NA hsa-miR-125a-3p PIK3R5 1.24490295132072 5.26925231010328e-06 -0.990769658200862 0.00792713202187119 miRanda -0.135508023882326 0.0399369211652034 NA NA NA hsa-miR-125a-5p PIK3R5 0.599529391575274 0.0102300147180307 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.398754902125041 2.22481895610409e-07 NA NA NA hsa-miR-182-5p PIK3R5 3.53923166221814 5.07781258121574e-21 -0.990769658200862 0.00792713202187119 MirTarget -0.391730270801049 4.50362857100536e-19 NA NA NA hsa-miR-185-5p PIK3R5 2.34016206907488 1.17481626642022e-26 -0.990769658200862 0.00792713202187119 MirTarget -0.277336834855249 0.000367374066791577 NA NA NA hsa-miR-18a-3p PIK3R5 2.14813400940323 2.23460809936028e-06 -0.990769658200862 0.00792713202187119 MirTarget -0.132688083528877 0.0077571943603639 NA NA NA hsa-miR-330-5p PIK3R5 1.15100069700871 4.85551805046014e-07 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.220865262481851 0.00496435762424894 NA NA NA hsa-miR-944 PIK3R5 2.91186649218281 1.31574753528144e-06 -0.990769658200862 0.00792713202187119 mirMAP -0.201291119960673 1.82909637448261e-11 NA NA NA hsa-let-7a-3p PRKAA2 1.42015538786275 7.03375209382654e-13 -3.1651157275578 4.06046613880045e-09 mirMAP -0.368546290584595 0.00514409913387135 NA NA NA hsa-let-7b-3p PRKAA2 0.868207752019623 1.30460056774366e-05 -3.1651157275578 4.06046613880045e-09 mirMAP -0.262674016711226 0.0494116538292108 NA NA NA hsa-let-7d-5p PRKAA2 1.33236798905207 1.1741085658466e-13 -3.1651157275578 4.06046613880045e-09 MirTarget -0.722750408548456 4.99138878435736e-07 NA NA NA hsa-let-7f-1-3p PRKAA2 1.55054488387679 7.31326775537952e-11 -3.1651157275578 4.06046613880045e-09 mirMAP -0.46638995733722 3.18954726371122e-05 NA NA NA hsa-let-7f-5p PRKAA2 0.495648727272215 0.00355972741198794 -3.1651157275578 4.06046613880045e-09 MirTarget -0.311815532548627 0.0490723533883445 NA NA NA hsa-let-7g-5p PRKAA2 1.20061455355116 1.50237505511483e-12 -3.1651157275578 4.06046613880045e-09 MirTarget -0.829014454032662 5.47891741707445e-08 NA NA NA hsa-let-7i-5p PRKAA2 0.412877696970403 0.00622731051981756 -3.1651157275578 4.06046613880045e-09 MirTarget -0.607502181924338 0.000681606877218508 NA NA NA hsa-miR-103a-2-5p PRKAA2 2.47599305985086 7.933028987326e-11 -3.1651157275578 4.06046613880045e-09 mirMAP -0.273304170202619 0.000379680069074106 NA NA NA hsa-miR-106b-5p PRKAA2 2.46782146831112 1.36171495805632e-23 -3.1651157275578 4.06046613880045e-09 mirMAP -0.449758621112524 9.45695175297387e-06 NA NA NA hsa-miR-125a-5p PRKAA2 0.599529391575274 0.0102300147180307 -3.1651157275578 4.06046613880045e-09 PITA -0.365087293868699 0.00135901058962619 NA NA NA hsa-miR-126-5p PRKAA2 0.895338176458417 2.33372756450713e-05 -3.1651157275578 4.06046613880045e-09 mirMAP -0.499415855416577 6.2491772215473e-05 NA NA NA hsa-miR-130b-3p PRKAA2 3.5350292994509 1.73934183852569e-27 -3.1651157275578 4.06046613880045e-09 MirTarget -0.30993060839259 4.53844629194696e-05 NA NA NA hsa-miR-141-3p PRKAA2 5.02396127982626 2.19224509139725e-24 -3.1651157275578 4.06046613880045e-09 mirMAP -0.311674641790567 3.76173236669185e-10 NA NA NA hsa-miR-142-5p PRKAA2 1.17581605694506 0.0018174701991234 -3.1651157275578 4.06046613880045e-09 mirMAP -0.307256732153854 1.00914367535293e-05 NA NA NA hsa-miR-146a-5p PRKAA2 1.19829319599115 0.00157081974524452 -3.1651157275578 4.06046613880045e-09 MirTarget -0.298359820970352 1.6416322978257e-05 NA NA NA hsa-miR-146b-5p PRKAA2 1.75587235896724 1.15724631266659e-07 -3.1651157275578 4.06046613880045e-09 MirTarget -0.311641849597315 7.38240690301751e-05 NA NA NA hsa-miR-15b-3p PRKAA2 2.33847028227712 4.29662877950836e-19 -3.1651157275578 4.06046613880045e-09 mirMAP -0.477684703528837 7.08126425805273e-07 NA NA NA hsa-miR-16-2-3p PRKAA2 2.31623086727196 4.29838149388188e-20 -3.1651157275578 4.06046613880045e-09 mirMAP -0.627940578646649 2.13766832392934e-10 NA NA NA hsa-miR-17-5p PRKAA2 3.2710598467455 9.93128340539455e-27 -3.1651157275578 4.06046613880045e-09 mirMAP -0.365611825057462 6.28601305540822e-06 NA NA NA hsa-miR-181a-2-3p PRKAA2 2.19062681262366 3.81790102612782e-13 -3.1651157275578 4.06046613880045e-09 mirMAP -0.446762077174767 1.28755345125413e-07 NA NA NA hsa-miR-181a-5p PRKAA2 2.29556023480783 1.8138457900616e-21 -3.1651157275578 4.06046613880045e-09 mirMAP -0.652763486781636 2.45814293770857e-10 NA NA NA hsa-miR-181b-5p PRKAA2 2.49307679431293 3.92829250217627e-20 -3.1651157275578 4.06046613880045e-09 mirMAP -0.553820083358037 1.79038809431955e-09 NA NA NA hsa-miR-182-5p PRKAA2 3.53923166221814 5.07781258121574e-21 -3.1651157275578 4.06046613880045e-09 miRNAWalker2_validate;MirTarget;mirMAP -0.331706760870251 5.94483360132956e-07 NA NA NA hsa-miR-186-5p PRKAA2 1.47445398888668 3.0781726595413e-15 -3.1651157275578 4.06046613880045e-09 MirTarget -0.526806950486461 0.000138268992490229 NA NA NA hsa-miR-192-5p PRKAA2 2.69002528723195 1.22990188194432e-16 -3.1651157275578 4.06046613880045e-09 miRNAWalker2_validate -0.161378715666907 0.0407539432354523 NA NA NA hsa-miR-19a-3p PRKAA2 3.42309334186656 3.02671914353412e-28 -3.1651157275578 4.06046613880045e-09 mirMAP -0.379428611341206 1.66931323472125e-06 NA NA NA hsa-miR-19b-3p PRKAA2 2.49529833021187 1.57028265846699e-23 -3.1651157275578 4.06046613880045e-09 mirMAP -0.447494148517396 8.06927629243583e-06 NA NA NA hsa-miR-200a-3p PRKAA2 4.59434485520731 6.38952518573476e-18 -3.1651157275578 4.06046613880045e-09 mirMAP -0.252415609716866 8.38336062600942e-08 NA NA NA hsa-miR-200b-3p PRKAA2 3.78235093249346 3.18343003239465e-14 -3.1651157275578 4.06046613880045e-09 MirTarget -0.261801092835381 2.7256487514151e-07 NA NA NA hsa-miR-200c-3p PRKAA2 3.50132673580082 2.42716349086937e-15 -3.1651157275578 4.06046613880045e-09 MirTarget -0.3165574137351 2.9537182424848e-08 NA NA NA hsa-miR-203a-3p PRKAA2 3.12352008343999 9.49391438647189e-07 -3.1651157275578 4.06046613880045e-09 MirTarget -0.114021445045374 0.00543014379350566 NA NA NA hsa-miR-20a-5p PRKAA2 3.15577933619191 4.19753346442454e-25 -3.1651157275578 4.06046613880045e-09 mirMAP -0.371335239957246 5.16233816597501e-06 NA NA NA hsa-miR-21-3p PRKAA2 2.19296355304364 4.63665722759779e-15 -3.1651157275578 4.06046613880045e-09 mirMAP -0.424686931257561 3.18678833497258e-06 NA NA NA hsa-miR-22-5p PRKAA2 1.88011544159252 1.63978222572222e-16 -3.1651157275578 4.06046613880045e-09 mirMAP -0.640613793079929 8.15181736251034e-09 NA NA NA hsa-miR-23a-3p PRKAA2 1.00493340843378 2.55313889288924e-08 -3.1651157275578 4.06046613880045e-09 mirMAP -0.717245625409375 7.83285299814301e-07 NA NA NA hsa-miR-26a-2-3p PRKAA2 0.823520019989974 0.00017092160823769 -3.1651157275578 4.06046613880045e-09 mirMAP -0.408717713181205 0.000788807753650383 NA NA NA hsa-miR-26a-5p PRKAA2 0.0464832722967259 0.752628386912329 -3.1651157275578 4.06046613880045e-09 mirMAP -0.397860835240243 0.0313650980967207 NA NA NA hsa-miR-26b-5p PRKAA2 0.885393662798425 3.2116297961629e-06 -3.1651157275578 4.06046613880045e-09 mirMAP -0.764962785810813 2.83597630191631e-08 NA NA NA hsa-miR-27b-5p PRKAA2 0.393316367667332 0.051702301924024 -3.1651157275578 4.06046613880045e-09 MirTarget;miRNATAP -0.383639737600614 0.0037825291986155 NA NA NA hsa-miR-29b-2-5p PRKAA2 0.910668640983475 0.00666655585493488 -3.1651157275578 4.06046613880045e-09 mirMAP -0.279808749959182 0.00038252900575232 NA NA NA hsa-miR-301a-3p PRKAA2 2.81024345929638 2.29784847962242e-17 -3.1651157275578 4.06046613880045e-09 MirTarget -0.231119799911066 0.0045176787682093 NA NA NA hsa-miR-30b-5p PRKAA2 0.800822374912712 0.000133601914525413 -3.1651157275578 4.06046613880045e-09 MirTarget -0.288057119153475 0.0233572155059335 NA NA NA hsa-miR-30c-5p PRKAA2 0.778774633108 0.000285599212429136 -3.1651157275578 4.06046613880045e-09 MirTarget -0.356922096763827 0.00395922355020181 NA NA NA hsa-miR-30d-3p PRKAA2 0.977747550180601 4.3048212205381e-05 -3.1651157275578 4.06046613880045e-09 MirTarget;miRNATAP -0.240071186464927 0.0307082267542837 NA NA NA hsa-miR-30d-5p PRKAA2 0.675423997639582 0.00270618816039773 -3.1651157275578 4.06046613880045e-09 MirTarget -0.271897797341097 0.0216937703176945 NA NA NA hsa-miR-30e-5p PRKAA2 1.23904909539663 1.35561917122157e-09 -3.1651157275578 4.06046613880045e-09 MirTarget -0.575531898888406 6.37486734638196e-06 NA NA NA hsa-miR-31-5p PRKAA2 3.59165123035072 2.27423212057482e-07 -3.1651157275578 4.06046613880045e-09 MirTarget -0.151730039535611 0.000135936484549104 NA NA NA hsa-miR-32-3p PRKAA2 2.02436999565685 5.94091197945307e-09 -3.1651157275578 4.06046613880045e-09 MirTarget -0.205177944089292 0.0165918636397811 NA NA NA hsa-miR-330-3p PRKAA2 0.876747334239085 0.00073709016089703 -3.1651157275578 4.06046613880045e-09 MirTarget -0.286102780581204 0.00506815071493037 NA NA NA hsa-miR-331-3p PRKAA2 2.28379581858927 1.99663919173155e-18 -3.1651157275578 4.06046613880045e-09 MirTarget -0.364561950555569 0.000185201672784168 NA NA NA hsa-miR-335-3p PRKAA2 3.08791651139852 5.31309869723517e-12 -3.1651157275578 4.06046613880045e-09 MirTarget -0.217607069917347 0.000151452265177902 NA NA NA hsa-miR-335-5p PRKAA2 1.77247705492746 2.22457658872091e-06 -3.1651157275578 4.06046613880045e-09 MirTarget;miRNATAP -0.189757321047362 0.00673896582128403 NA NA NA hsa-miR-33a-3p PRKAA2 1.72765312072219 1.51784443453521e-07 -3.1651157275578 4.06046613880045e-09 mirMAP -0.197716151311991 0.0240888641750769 NA NA NA hsa-miR-342-3p PRKAA2 1.49115144672245 1.43879249744621e-07 -3.1651157275578 4.06046613880045e-09 PITA -0.365301673219482 7.27987168209179e-05 NA NA NA hsa-miR-34a-5p PRKAA2 1.9016323452565 1.43092834643601e-14 -3.1651157275578 4.06046613880045e-09 miRNATAP -0.697992393841294 7.93258270698692e-12 NA NA NA hsa-miR-374a-3p PRKAA2 0.533309330504947 0.00192918429705142 -3.1651157275578 4.06046613880045e-09 mirMAP -0.468265324710388 0.0026860278599259 NA NA NA hsa-miR-429 PRKAA2 4.48815175680773 2.44117492218206e-17 -3.1651157275578 4.06046613880045e-09 MirTarget;miRNATAP -0.234368381119893 8.26598458529829e-07 NA NA NA hsa-miR-454-3p PRKAA2 2.47234127820054 1.12878018736016e-21 -3.1651157275578 4.06046613880045e-09 MirTarget -0.516124002344748 2.14118798191959e-07 NA NA NA hsa-miR-500a-5p PRKAA2 1.72110365584658 3.0807246212659e-10 -3.1651157275578 4.06046613880045e-09 mirMAP -0.291639409971857 0.00221883780805263 NA NA NA hsa-miR-576-5p PRKAA2 2.20467023993664 3.4053475193793e-19 -3.1651157275578 4.06046613880045e-09 mirMAP -0.576206223473929 1.6711936398277e-08 NA NA NA hsa-miR-582-5p PRKAA2 0.609226359812689 0.032988717891497 -3.1651157275578 4.06046613880045e-09 mirMAP -0.270459108094453 0.00363606827304358 NA NA NA hsa-miR-589-5p PRKAA2 1.71990116752371 8.310889042056e-14 -3.1651157275578 4.06046613880045e-09 MirTarget -0.376078241087496 0.00080032835281227 NA NA NA hsa-miR-590-3p PRKAA2 2.59289455139753 1.03200520972022e-21 -3.1651157275578 4.06046613880045e-09 mirMAP;miRNATAP -0.430999919941564 6.04499840743536e-06 NA NA NA hsa-miR-664a-3p PRKAA2 0.634721925861133 0.00520070178640421 -3.1651157275578 4.06046613880045e-09 MirTarget -0.510084786462165 1.19979296115228e-05 NA NA NA hsa-miR-7-1-3p PRKAA2 1.84950311431067 1.25300363397654e-13 -3.1651157275578 4.06046613880045e-09 MirTarget;mirMAP -0.360511833799086 0.000488208563484811 NA NA NA hsa-miR-93-5p PRKAA2 3.03961860136032 1.11672209617395e-24 -3.1651157275578 4.06046613880045e-09 mirMAP -0.360317996321163 1.81157969199634e-05 NA NA NA hsa-miR-944 PRKAA2 2.91186649218281 1.31574753528144e-06 -3.1651157275578 4.06046613880045e-09 mirMAP -0.304599294327695 3.71005202161829e-12 NA NA NA hsa-miR-96-5p PRKAA2 4.89433085814374 1.92000659886961e-31 -3.1651157275578 4.06046613880045e-09 TargetScan -0.301126902372243 4.20848274807667e-07 NA NA NA hsa-miR-98-5p PRKAA2 1.11154309866014 1.24143909012085e-08 -3.1651157275578 4.06046613880045e-09 miRNAWalker2_validate;MirTarget -0.364025165304353 0.00705071490635534 NA NA NA hsa-let-7i-5p RICTOR 0.412877696970403 0.00622731051981756 -0.0636558558251128 0.690801456304219 MirTarget;miRNATAP -0.181498389332032 0.000474512978277903 NA NA NA hsa-miR-139-5p RICTOR -1.52606598644743 1.20474151350665e-08 -0.0636558558251128 0.690801456304219 MirTarget;PITA;miRanda -0.117309140283128 3.26793845059091e-05 NA NA NA hsa-miR-140-3p RICTOR 0.0608890720479334 0.727716871248724 -0.0636558558251128 0.690801456304219 MirTarget;PITA;miRNATAP -0.139944872162773 0.00177546724259963 NA NA NA hsa-miR-218-5p RICTOR -0.573801507392184 0.0551983860126703 -0.0636558558251128 0.690801456304219 miRNAWalker2_validate;miRTarBase;miRNATAP -0.128099349308607 5.27766413859692e-07 NA NA NA hsa-miR-495-3p RICTOR -0.0847115949846082 0.763475496144456 -0.0636558558251128 0.690801456304219 MirTarget -0.143309782555465 1.46249599436837e-07 NA NA NA hsa-miR-497-5p RICTOR 0.0257087130056286 0.918145413833358 -0.0636558558251128 0.690801456304219 MirTarget;miRNATAP -0.107838893771902 0.000492230040753755 NA NA NA hsa-miR-660-5p RICTOR 1.82692095272076 1.92040083607196e-13 -0.0636558558251128 0.690801456304219 MirTarget -0.125254027693193 3.16011915894253e-05 NA NA NA hsa-miR-125b-5p RPS6KA1 -1.16462950151259 0.000288900271798384 1.34988540411024 1.15370611659724e-11 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.13692356644705 6.2422468067932e-06 NA NA NA hsa-miR-139-5p RPS6KA1 -1.52606598644743 1.20474151350665e-08 1.34988540411024 1.15370611659724e-11 miRanda -0.104159748301514 0.00411281450359946 NA NA NA hsa-let-7g-3p RPS6KA2 3.26398061402445 3.96263126107645e-25 -1.89918037721253 3.87074381310148e-13 MirTarget -0.246721753553459 3.41630640648566e-10 NA NA NA hsa-miR-1271-5p RPS6KA2 0.970418832993172 0.000609742584380688 -1.89918037721253 3.87074381310148e-13 mirMAP -0.20251993530887 9.27638787048565e-06 NA NA NA hsa-miR-130b-5p RPS6KA2 2.9963110846538 1.98883029416455e-18 -1.89918037721253 3.87074381310148e-13 mirMAP -0.235363829031829 1.54980286279085e-10 NA NA NA hsa-miR-17-5p RPS6KA2 3.2710598467455 9.93128340539455e-27 -1.89918037721253 3.87074381310148e-13 TargetScan -0.308938986160142 1.53086675306477e-15 NA NA NA hsa-miR-181a-2-3p RPS6KA2 2.19062681262366 3.81790102612782e-13 -1.89918037721253 3.87074381310148e-13 mirMAP -0.185814296672575 8.43603766197703e-06 NA NA NA hsa-miR-185-3p RPS6KA2 2.3922478518806 1.3373426768452e-14 -1.89918037721253 3.87074381310148e-13 MirTarget -0.23896304263491 2.26811072773796e-09 NA NA NA hsa-miR-193a-3p RPS6KA2 1.60460546928078 2.86169793322984e-07 -1.89918037721253 3.87074381310148e-13 mirMAP -0.182027317307988 8.38861562840483e-06 NA NA NA hsa-miR-193b-3p RPS6KA2 2.25711804611899 4.1940744806631e-14 -1.89918037721253 3.87074381310148e-13 mirMAP -0.311500359089077 3.53991075205589e-14 NA NA NA hsa-miR-19a-3p RPS6KA2 3.42309334186656 3.02671914353412e-28 -1.89918037721253 3.87074381310148e-13 MirTarget -0.274673751333933 6.75653405295878e-13 NA NA NA hsa-miR-19b-3p RPS6KA2 2.49529833021187 1.57028265846699e-23 -1.89918037721253 3.87074381310148e-13 MirTarget -0.319321802710713 4.74464788644084e-11 NA NA NA hsa-miR-200c-3p RPS6KA2 3.50132673580082 2.42716349086937e-15 -1.89918037721253 3.87074381310148e-13 miRNATAP -0.129334089352011 4.4517289901593e-06 NA NA NA hsa-miR-21-3p RPS6KA2 2.19296355304364 4.63665722759779e-15 -1.89918037721253 3.87074381310148e-13 MirTarget -0.272784541769791 7.52288789174635e-10 NA NA NA hsa-miR-26b-5p RPS6KA2 0.885393662798425 3.2116297961629e-06 -1.89918037721253 3.87074381310148e-13 miRNATAP -0.227177310507267 0.000899668091721707 NA NA NA hsa-miR-3065-5p RPS6KA2 2.74629919868982 1.86846589298284e-08 -1.89918037721253 3.87074381310148e-13 mirMAP -0.129392772331137 5.16506987695122e-05 NA NA NA hsa-miR-30e-5p RPS6KA2 1.23904909539663 1.35561917122157e-09 -1.89918037721253 3.87074381310148e-13 MirTarget -0.167397027801108 0.00795729353132801 NA NA NA hsa-miR-3127-5p RPS6KA2 1.51846438737133 3.59571251672767e-07 -1.89918037721253 3.87074381310148e-13 mirMAP -0.13587142025251 0.00161943122406181 NA NA NA hsa-miR-532-3p RPS6KA2 1.96631878320218 4.53421954361695e-13 -1.89918037721253 3.87074381310148e-13 MirTarget;mirMAP -0.217249391578203 2.76835498444362e-06 NA NA NA hsa-miR-589-5p RPS6KA2 1.71990116752371 8.310889042056e-14 -1.89918037721253 3.87074381310148e-13 mirMAP -0.333681503852927 7.42768576140755e-10 NA NA NA hsa-miR-93-3p RPS6KA2 2.85383869771942 5.64481766902125e-23 -1.89918037721253 3.87074381310148e-13 MirTarget -0.236183258286661 2.11710105875058e-08 NA NA NA hsa-let-7d-5p RPS6KA3 1.33236798905207 1.1741085658466e-13 -0.370806818018999 0.0220707753218686 miRNATAP -0.114489938702704 0.00756705340948625 NA NA NA hsa-miR-136-5p RPS6KA3 2.09637138292451 1.50140005592201e-10 -0.370806818018999 0.0220707753218686 mirMAP -0.117791568961288 3.67256904611671e-07 NA NA NA hsa-miR-181a-5p RPS6KA3 2.29556023480783 1.8138457900616e-21 -0.370806818018999 0.0220707753218686 MirTarget;mirMAP;miRNATAP -0.121039283729606 8.78983023529811e-05 NA NA NA hsa-miR-181c-5p RPS6KA3 1.58587920618301 1.57506918816933e-10 -0.370806818018999 0.0220707753218686 MirTarget;mirMAP;miRNATAP -0.137925322197845 7.60328156936309e-06 NA NA NA hsa-miR-186-5p RPS6KA3 1.47445398888668 3.0781726595413e-15 -0.370806818018999 0.0220707753218686 MirTarget;mirMAP;miRNATAP -0.111734638474146 0.00635139835787659 NA NA NA hsa-miR-21-5p RPS6KA3 2.73773305747971 1.38864982139576e-43 -0.370806818018999 0.0220707753218686 miRNAWalker2_validate;mirMAP;miRNATAP -0.115651579127679 0.00124546897217506 NA NA NA hsa-miR-320a RPS6KA3 0.438165828017084 0.0390159073347133 -0.370806818018999 0.0220707753218686 miRNAWalker2_validate;miRanda -0.105734074591902 0.00443346974555563 NA NA NA hsa-miR-1271-5p RPS6KA6 0.970418832993172 0.000609742584380688 -0.643070571271251 0.264542356112038 MirTarget -0.28783551839478 0.00344430588607334 NA NA NA hsa-miR-199a-3p RPS6KA6 0.640600337515787 0.0380326905134914 -0.643070571271251 0.264542356112038 MirTarget -0.494218120175028 2.93790214049553e-08 NA NA NA hsa-miR-199b-3p RPS6KA6 0.643923492750702 0.0371742251925406 -0.643070571271251 0.264542356112038 MirTarget -0.493553319945077 2.99976098785352e-08 NA NA NA hsa-miR-217 RPS6KA6 0.608024397387488 0.199352491710517 -0.643070571271251 0.264542356112038 miRanda -0.218929391103907 0.000280286435780485 NA NA NA hsa-miR-338-5p RPS6KA6 -0.577691606146419 0.0472212680542825 -0.643070571271251 0.264542356112038 MirTarget -0.211094505598065 0.0294237857264803 NA NA NA hsa-miR-424-5p RPS6KA6 1.61930224569578 1.89642549274994e-10 -0.643070571271251 0.264542356112038 MirTarget -0.275006218909343 0.0107505875800356 NA NA NA hsa-miR-655-3p RPS6KA6 0.485339318272148 0.137014658258732 -0.643070571271251 0.264542356112038 MirTarget -0.294210829929277 0.000704709579255314 NA NA NA hsa-miR-708-3p RPS6KA6 2.80907765282502 3.07460722669281e-14 -0.643070571271251 0.264542356112038 MirTarget -0.173132616422874 0.017829398044062 NA NA NA hsa-miR-26a-5p ULK1 0.0464832722967259 0.752628386912329 0.168631118107132 0.26676283173824 miRNATAP -0.17543741443891 0.000545660569952753 NA NA NA hsa-miR-338-5p ULK1 -0.577691606146419 0.0472212680542825 0.168631118107132 0.26676283173824 PITA -0.136183558809384 5.60724774968058e-08 NA NA NA hsa-let-7d-5p ULK2 1.33236798905207 1.1741085658466e-13 -0.582426572411284 0.00379371000646104 MirTarget -0.111425190965775 0.0372609723503154 NA NA NA hsa-let-7e-5p ULK2 0.860104282510173 6.04758298373779e-05 -0.582426572411284 0.00379371000646104 MirTarget -0.106151678752928 0.0198281047608298 NA NA NA hsa-let-7f-1-3p ULK2 1.55054488387679 7.31326775537952e-11 -0.582426572411284 0.00379371000646104 MirTarget -0.125305835260512 0.00247463325840322 NA NA NA hsa-let-7g-5p ULK2 1.20061455355116 1.50237505511483e-12 -0.582426572411284 0.00379371000646104 MirTarget -0.165050528466831 0.00363550241375785 NA NA NA hsa-let-7i-5p ULK2 0.412877696970403 0.00622731051981756 -0.582426572411284 0.00379371000646104 MirTarget -0.172181963679009 0.00898713806249386 NA NA NA hsa-miR-140-5p ULK2 0.844753502512594 3.73722278438606e-05 -0.582426572411284 0.00379371000646104 miRanda -0.184727637468753 9.90523092823506e-05 NA NA NA hsa-miR-186-5p ULK2 1.47445398888668 3.0781726595413e-15 -0.582426572411284 0.00379371000646104 MirTarget -0.157734543365668 0.00196013457709713 NA NA NA hsa-miR-22-3p ULK2 1.21545661147757 1.61670170137775e-13 -0.582426572411284 0.00379371000646104 MirTarget -0.16192209246504 0.00556684151656764 NA NA NA hsa-miR-26a-5p ULK2 0.0464832722967259 0.752628386912329 -0.582426572411284 0.00379371000646104 MirTarget -0.137064696597495 0.0436845224449156 NA NA NA hsa-miR-26b-5p ULK2 0.885393662798425 3.2116297961629e-06 -0.582426572411284 0.00379371000646104 MirTarget -0.240421415650889 2.31215037237229e-06 26920049 MiR 26b inhibits autophagy by targeting ULK2 in prostate cancer cells; We found that miR-26b inhibited autophagy in PC-3 and C4-2 cells through down-regulation of ULK2 expression; Dual luciferase reporter assays showed that miR-26b binds the 3'UTR of ULK2 suggesting that ULK2 is a direct target of miR-26b; Real-time PCR and Western blot analysis confirmed that over-expression of miR-26b reduced ULK2 mRNA and protein levels; Taken together our findings indicate that mir-26b inhibits autophagy through targeting ULK2 which is up-regulated in PCa prostate cancer hsa-miR-361-5p ULK2 0.971859117235239 5.30236555707088e-09 -0.582426572411284 0.00379371000646104 miRanda;miRNATAP -0.119325589320004 0.0417407337553628 NA NA NA hsa-miR-362-3p ULK2 2.0756816987665 3.89026064579331e-12 -0.582426572411284 0.00379371000646104 miRNATAP -0.107486427614139 0.00106480930288894 NA NA NA hsa-miR-576-5p ULK2 2.20467023993664 3.4053475193793e-19 -0.582426572411284 0.00379371000646104 mirMAP -0.157539740944837 3.14539499378473e-05 NA NA NA hsa-miR-582-5p ULK2 0.609226359812689 0.032988717891497 -0.582426572411284 0.00379371000646104 miRNATAP -0.156069010259381 4.20782665050971e-06 NA NA NA hsa-miR-590-3p ULK2 2.59289455139753 1.03200520972022e-21 -0.582426572411284 0.00379371000646104 mirMAP -0.16610742386826 2.02217872445913e-06 NA NA NA hsa-miR-125b-5p ULK3 -1.16462950151259 0.000288900271798384 0.488619672684837 0.00278933779897925 miRNAWalker2_validate -0.134861810614726 2.44640037676076e-08 NA NA NA hsa-miR-1-3p VEGFA -3.48370702447685 1.98579484008516e-13 0.471653090802802 0.0989904385682923 MirTarget -0.202978528176548 1.57292170658149e-13 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-133a-3p VEGFA -3.38501431117712 1.32336729742128e-13 0.471653090802802 0.0989904385682923 miRNAWalker2_validate -0.190996958246616 2.70660605752725e-11 NA NA NA hsa-miR-134-5p VEGFA 0.141163006984518 0.655334296084178 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase;MirTarget -0.180227374251871 3.58435465670397e-05 NA NA NA hsa-miR-145-5p VEGFA -1.55259331973517 9.97889123247165e-07 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase -0.277645238248207 4.72205041776188e-11 24966896;24781864;22472569 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically ;metastasis; bladder cancer;thyroid cancer;sarcoma hsa-miR-150-5p VEGFA -0.105827294491332 0.799351458244375 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase -0.164137084593398 6.0374913950269e-07 NA NA NA hsa-miR-195-5p VEGFA -1.44753678070504 8.70594292149271e-09 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase;MirTarget -0.21863878149299 5.11037236008283e-05 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199a-5p VEGFA 0.592984035153911 0.0674836634175293 0.471653090802802 0.0989904385682923 miRanda;miRNATAP -0.205612739501636 1.1489897892283e-06 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA 0.218704279044827 0.519493319158441 0.471653090802802 0.0989904385682923 miRanda -0.175899050515122 1.43171320791549e-05 NA NA NA hsa-miR-29a-3p VEGFA -0.35074463683376 0.161238718982428 0.471653090802802 0.0989904385682923 MirTarget -0.313847513848792 9.68544057650496e-09 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-342-3p VEGFA 1.49115144672245 1.43879249744621e-07 0.471653090802802 0.0989904385682923 miRanda;miRNATAP -0.166390639835536 0.000539599594707828 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-374b-5p VEGFA 0.0654362503857184 0.722673188879465 0.471653090802802 0.0989904385682923 MirTarget -0.254824056474554 0.000792850845311603 NA NA NA hsa-miR-655-3p VEGFA 0.485339318272148 0.137014658258732 0.471653090802802 0.0989904385682923 MirTarget -0.164823030617487 0.000126415331270495 NA NA NA hsa-miR-128-3p VEGFC 1.63756041666078 6.79626586407187e-14 -0.457873556695705 0.178610332401836 miRNAWalker2_validate;MirTarget -0.377058704312277 2.16798927147771e-07 26722309;25001183 miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells;Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways metastasis; bladder cancer;lung squamous cell cancer hsa-miR-27b-3p VEGFC 0.196007704287769 0.295630157035388 -0.457873556695705 0.178610332401836 MirTarget -0.184894953706514 0.038219701457811 23593282 We identified vascular endothelial growth factor C VEGFC as a novel target gene of miR-27b and determined that miR-27b functioned as an inhibitor of tumor progression and angiogenesis through targeting VEGFC in CRC; In summary an anti-tumor role for miR-27b and its novel target VEGFC in vivo could lead to tumor necrosis and provide a rationale for developing miR-27b as a therapeutic agent progression colorectal cancer