miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-3p APC 0.0530563276543763 0.370749834463566 -0.147586350639612 0.0226929526202108 mirMAP -0.209043222673541 5.13926171681088e-07 NA NA NA hsa-miR-106b-5p APC 0.167096183547615 0.0497544396383451 -0.147586350639612 0.0226929526202108 miRNAWalker2_validate;miRTarBase -0.114524224223111 0.000101236641222059 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells liver cancer hsa-miR-320a APC 0.092135599636725 0.243028758989929 -0.147586350639612 0.0226929526202108 miRanda -0.163258126777036 3.07643781773329e-06 NA NA NA hsa-miR-590-3p APC 0.312951515438396 0.000480455423843996 -0.147586350639612 0.0226929526202108 PITA;miRanda;mirMAP;miRNATAP -0.111046172826835 6.34158277218567e-06 NA NA NA hsa-miR-1226-3p APC2 -0.098618802853881 0.346683714981524 -0.236175351073451 0.00192842503683438 mirMAP -0.206555240277595 7.13818871835793e-18 NA NA NA hsa-miR-125a-5p APC2 -0.0833349424517387 0.325440200253607 -0.236175351073451 0.00192842503683438 mirMAP -0.230876250834094 4.79197726931088e-10 NA NA NA hsa-miR-125b-5p APC2 -0.0119698382910496 0.890233923197358 -0.236175351073451 0.00192842503683438 mirMAP -0.18537052701664 3.74100180140819e-05 NA NA NA hsa-miR-1306-3p APC2 0.00176275623326516 0.98648095764438 -0.236175351073451 0.00192842503683438 mirMAP -0.192419354772092 1.00199138701415e-14 NA NA NA hsa-miR-185-3p APC2 -0.133219014400353 0.255713818728239 -0.236175351073451 0.00192842503683438 MirTarget -0.134382430533834 5.86994627492573e-10 NA NA NA hsa-miR-185-5p APC2 -0.0767432095218297 0.404113540276816 -0.236175351073451 0.00192842503683438 miRNATAP -0.239905026592726 9.42057405034032e-17 NA NA NA hsa-miR-199a-5p APC2 0.174889610847968 0.0900027418912454 -0.236175351073451 0.00192842503683438 mirMAP -0.240642418774449 4.75833740978397e-23 NA NA NA hsa-miR-20a-3p APC2 0.102743778777997 0.19677865359751 -0.236175351073451 0.00192842503683438 mirMAP -0.115679108023319 0.000423255328027058 NA NA NA hsa-miR-2355-5p APC2 0.00808596988211185 0.916165501155096 -0.236175351073451 0.00192842503683438 mirMAP -0.363578220663697 3.46652492136815e-27 NA NA NA hsa-miR-27a-5p APC2 0.588526581446 1.44259383783551e-07 -0.236175351073451 0.00192842503683438 mirMAP -0.132633070274358 5.14226615608852e-09 NA NA NA hsa-miR-28-5p APC2 0.104003572105781 0.153594705579534 -0.236175351073451 0.00192842503683438 mirMAP -0.293866982134949 3.17571848444092e-15 NA NA NA hsa-miR-324-3p APC2 -0.0103367134443655 0.904494071318044 -0.236175351073451 0.00192842503683438 mirMAP -0.294058405876126 8.81266575441715e-23 NA NA NA hsa-miR-340-3p APC2 -0.107892544857248 0.133625392070518 -0.236175351073451 0.00192842503683438 mirMAP -0.261278683722307 3.2516787620797e-12 NA NA NA hsa-miR-345-5p APC2 0.0352125534663932 0.724232171311864 -0.236175351073451 0.00192842503683438 mirMAP -0.205969262053811 5.98644937704124e-16 NA NA NA hsa-miR-361-3p APC2 -0.0798653643614555 0.271064714084553 -0.236175351073451 0.00192842503683438 mirMAP -0.316171343395539 1.97778199774211e-15 NA NA NA hsa-miR-484 APC2 -0.0190828819137732 0.802298900989652 -0.236175351073451 0.00192842503683438 mirMAP -0.306242827213748 3.981128624185e-18 NA NA NA hsa-miR-500a-3p APC2 0.0479457078972052 0.49420307623914 -0.236175351073451 0.00192842503683438 mirMAP -0.235605753688155 4.05722939524601e-08 NA NA NA hsa-miR-505-5p APC2 0.0973008785018434 0.183209581426791 -0.236175351073451 0.00192842503683438 mirMAP -0.200736124664729 1.51415660726357e-08 NA NA NA hsa-miR-625-5p APC2 -0.0264137834407145 0.802098211251158 -0.236175351073451 0.00192842503683438 mirMAP -0.143347643362362 3.76618634877325e-09 NA NA NA hsa-miR-708-5p APC2 -0.00936519718301376 0.919857671524527 -0.236175351073451 0.00192842503683438 mirMAP -0.102730587696755 0.00068705065617623 NA NA NA hsa-miR-940 APC2 -0.0183807673806575 0.881747775878136 -0.236175351073451 0.00192842503683438 MirTarget -0.181101825816814 2.57838035085502e-19 NA NA NA hsa-miR-126-5p AXIN1 0.177332403948664 0.0711675116243123 0.0531060862017183 0.244111793554156 miRNATAP -0.102646807414393 4.20473409646464e-11 NA NA NA hsa-miR-484 AXIN1 -0.0190828819137732 0.802298900989652 0.0531060862017183 0.244111793554156 miRNAWalker2_validate -0.109700210099152 1.19783484748919e-07 NA NA NA hsa-miR-769-3p AXIN1 -0.287263649023213 0.018145224330845 0.0531060862017183 0.244111793554156 miRNAWalker2_validate -0.12273723551735 4.10319562530541e-26 NA NA NA hsa-miR-15a-5p AXIN2 0.142658985373611 0.0536219185009004 -0.247224354694479 5.12016197774521e-05 MirTarget;miRNATAP -0.21577120923868 2.97936480118856e-08 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-15b-5p AXIN2 0.592863156692837 1.41971517354055e-10 -0.247224354694479 5.12016197774521e-05 miRTarBase;MirTarget;miRNATAP -0.166519145789269 6.08522213435711e-10 NA NA NA hsa-miR-16-5p AXIN2 0.246024668671282 0.00346042804503716 -0.247224354694479 5.12016197774521e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.178257323703335 9.65209503309727e-08 NA NA NA hsa-miR-424-5p AXIN2 0.25140374049676 0.00709934939774983 -0.247224354694479 5.12016197774521e-05 MirTarget;miRNATAP -0.146811872399928 3.61794564299052e-08 NA NA NA hsa-miR-590-3p AXIN2 0.312951515438396 0.000480455423843996 -0.247224354694479 5.12016197774521e-05 MirTarget;PITA;miRanda;miRNATAP -0.113828393990003 1.95398520001851e-05 NA NA NA hsa-miR-130b-3p BTRC 0.503911467685709 9.46590588950823e-08 -0.316428267869541 1.32837645909608e-08 mirMAP -0.104243891156098 1.4826389515275e-06 NA NA NA hsa-miR-15a-5p BTRC 0.142658985373611 0.0536219185009004 -0.316428267869541 1.32837645909608e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.201204400341484 8.00040793919774e-10 NA NA NA hsa-miR-15b-5p BTRC 0.592863156692837 1.41971517354055e-10 -0.316428267869541 1.32837645909608e-08 MirTarget;miRNATAP -0.208639851908834 5.15087327755483e-21 NA NA NA hsa-miR-16-1-3p BTRC 0.346674816118499 1.86447850167636e-05 -0.316428267869541 1.32837645909608e-08 mirMAP -0.11487582004524 4.39685292232459e-06 NA NA NA hsa-miR-16-5p BTRC 0.246024668671282 0.00346042804503716 -0.316428267869541 1.32837645909608e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.12080074368995 2.0271619043445e-05 NA NA NA hsa-miR-200c-3p BTRC 0.413752622631695 8.6936333715621e-06 -0.316428267869541 1.32837645909608e-08 mirMAP -0.123386018168531 9.16758160713923e-09 NA NA NA hsa-miR-320a BTRC 0.092135599636725 0.243028758989929 -0.316428267869541 1.32837645909608e-08 miRNAWalker2_validate;PITA -0.151655455781543 2.08156638100644e-06 NA NA NA hsa-miR-320b BTRC 0.283477746304177 0.0005953763020907 -0.316428267869541 1.32837645909608e-08 PITA -0.127026223619101 1.6807185042244e-07 NA NA NA hsa-miR-320c BTRC 0.343259124189966 0.000248338401291051 -0.316428267869541 1.32837645909608e-08 PITA;mirMAP -0.15675209017671 5.99889323999288e-13 NA NA NA hsa-miR-339-5p BTRC 0.273253751377152 0.0185300170790638 -0.316428267869541 1.32837645909608e-08 MirTarget;miRanda -0.123980890139708 4.29087303040382e-13 NA NA NA hsa-miR-3913-5p BTRC 0.276883251911602 0.00186113779811511 -0.316428267869541 1.32837645909608e-08 mirMAP -0.14030086026663 4.23427782985035e-10 NA NA NA hsa-miR-501-5p BTRC 0.0878951859817452 0.309663377222443 -0.316428267869541 1.32837645909608e-08 mirMAP -0.105268960652687 7.00797287103198e-06 NA NA NA hsa-miR-576-5p BTRC 0.106482276040047 0.194379152564166 -0.316428267869541 1.32837645909608e-08 mirMAP -0.113442612716801 5.31024992254411e-06 NA NA NA hsa-miR-590-3p BTRC 0.312951515438396 0.000480455423843996 -0.316428267869541 1.32837645909608e-08 mirMAP -0.132299349156721 3.06021995554098e-09 NA NA NA hsa-miR-629-5p BTRC 0.100422082714475 0.214291160007531 -0.316428267869541 1.32837645909608e-08 mirMAP -0.111625784957241 4.01206568195589e-05 NA NA NA hsa-miR-10a-5p CAMK2A 1.10332501906319 5.3831631561183e-08 -1.05483486466104 1.50460233407786e-05 mirMAP -0.153661642035624 0.00325738191077055 NA NA NA hsa-miR-10b-5p CAMK2A 1.54586540986745 2.64595843546465e-08 -1.05483486466104 1.50460233407786e-05 mirMAP -0.180135301414051 2.43309049480753e-06 NA NA NA hsa-miR-1262 CAMK2A 0.276259331706731 0.0259799942226561 -1.05483486466104 1.50460233407786e-05 mirMAP -0.485556313094844 2.33960726797583e-08 NA NA NA hsa-miR-130b-5p CAMK2A 0.413070888963592 1.98866876365509e-06 -1.05483486466104 1.50460233407786e-05 mirMAP -0.553510970199575 1.17559467227697e-05 NA NA NA hsa-miR-21-3p CAMK2A 1.3484283943822 2.0036022227401e-17 -1.05483486466104 1.50460233407786e-05 MirTarget -0.516975229672593 1.3585319454321e-15 NA NA NA hsa-miR-27a-3p CAMK2A 0.303760032895792 0.00457375391189806 -1.05483486466104 1.50460233407786e-05 mirMAP;miRNATAP -0.465649035581147 1.48988517267184e-05 NA NA NA hsa-miR-320c CAMK2A 0.343259124189966 0.000248338401291051 -1.05483486466104 1.50460233407786e-05 mirMAP -0.605234080939353 1.94595914787861e-07 NA NA NA hsa-miR-3913-5p CAMK2A 0.276883251911602 0.00186113779811511 -1.05483486466104 1.50460233407786e-05 mirMAP -0.596986165573949 5.7426359514171e-07 NA NA NA hsa-miR-10b-5p CAMK2B 1.54586540986745 2.64595843546465e-08 -0.332377348457309 0.0229717947145306 miRNATAP -0.101099127341402 7.37864929638483e-06 NA NA NA hsa-miR-186-5p CAMK2B 0.0606381894130505 0.514217717592464 -0.332377348457309 0.0229717947145306 miRNAWalker2_validate;miRNATAP -0.19329454197859 0.00994027009813768 NA NA NA hsa-miR-296-5p CAMK2B -0.0192165981442809 0.870822664524408 -0.332377348457309 0.0229717947145306 mirMAP -0.182193772915921 0.000656325585269752 NA NA NA hsa-miR-3065-3p CAMK2B -0.261348288537884 0.0343753235107924 -0.332377348457309 0.0229717947145306 mirMAP -0.29523699728451 2.41607851424247e-08 NA NA NA hsa-miR-3913-5p CAMK2B 0.276883251911602 0.00186113779811511 -0.332377348457309 0.0229717947145306 mirMAP -0.347606875166861 7.96991997414697e-07 NA NA NA hsa-miR-589-3p CAMK2B 0.00739371736361305 0.927768051649329 -0.332377348457309 0.0229717947145306 MirTarget -0.25750012459456 0.000983238686278576 NA NA NA hsa-miR-1262 CAMK2G 0.276259331706731 0.0259799942226561 -0.592625256157559 9.94215138360615e-14 miRNATAP -0.128521695838084 5.90430363247061e-07 NA NA NA hsa-miR-16-2-3p CAMK2G 0.468816222075619 7.04377763166292e-05 -0.592625256157559 9.94215138360615e-14 mirMAP -0.136855591611257 1.87352003186792e-07 NA NA NA hsa-miR-16-5p CAMK2G 0.246024668671282 0.00346042804503716 -0.592625256157559 9.94215138360615e-14 miRNAWalker2_validate -0.244521990030007 2.54193296329551e-08 NA NA NA hsa-miR-17-3p CAMK2G 0.0217768908350733 0.801140991374649 -0.592625256157559 9.94215138360615e-14 miRNATAP -0.188841817372218 6.04260142415985e-06 NA NA NA hsa-miR-195-3p CAMK2G 0.100105455903079 0.133362389112338 -0.592625256157559 9.94215138360615e-14 mirMAP -0.146748048719832 0.00265195357936532 NA NA NA hsa-miR-320a CAMK2G 0.092135599636725 0.243028758989929 -0.592625256157559 9.94215138360615e-14 miRanda -0.278300407311666 1.99407406141252e-08 NA NA NA hsa-miR-320b CAMK2G 0.283477746304177 0.0005953763020907 -0.592625256157559 9.94215138360615e-14 miRanda -0.243200781595863 9.64075754270534e-11 NA NA NA hsa-miR-320c CAMK2G 0.343259124189966 0.000248338401291051 -0.592625256157559 9.94215138360615e-14 miRanda -0.157480923510824 4.75363464546174e-06 NA NA NA hsa-miR-452-5p CAMK2G 0.599327068454211 1.02031931068531e-05 -0.592625256157559 9.94215138360615e-14 miRNATAP -0.153517284483997 1.14775677420335e-11 NA NA NA hsa-miR-590-3p CAMK2G 0.312951515438396 0.000480455423843996 -0.592625256157559 9.94215138360615e-14 miRanda -0.166410256925174 1.96090395524884e-06 NA NA NA hsa-let-7e-5p CCND1 0.0471189209570344 0.657255455444655 0.517304800763483 1.04046594178888e-06 miRTarBase;miRNATAP -0.228941875441154 1.78800254985128e-06 NA NA NA hsa-let-7i-5p CCND1 0.0952853587923244 0.192120688957249 0.517304800763483 1.04046594178888e-06 miRNATAP -0.236343082962889 0.00183350614645 NA NA NA hsa-miR-1266-5p CCND1 0.313515127917259 0.0138664194727392 0.517304800763483 1.04046594178888e-06 MirTarget -0.112027246009442 0.00108554865163972 NA NA NA hsa-miR-135a-5p CCND1 -0.122734612943241 0.196985964641886 0.517304800763483 1.04046594178888e-06 mirMAP -0.247492714890572 1.3238406350361e-07 NA NA NA hsa-miR-23b-3p CCND1 0.0476610245860094 0.630277683372344 0.517304800763483 1.04046594178888e-06 miRNATAP -0.279243855267394 9.57342364736838e-09 NA NA NA hsa-miR-26b-5p CCND1 -0.0984536538762768 0.231803769574623 0.517304800763483 1.04046594178888e-06 miRNAWalker2_validate -0.171067179820866 0.00692173397836684 NA NA NA hsa-miR-29a-3p CCND1 -0.224140851576083 0.0349516103550236 0.517304800763483 1.04046594178888e-06 mirMAP -0.23358540897967 1.12603356998685e-05 NA NA NA hsa-miR-29b-3p CCND1 -0.178522712044497 0.0856106432165465 0.517304800763483 1.04046594178888e-06 mirMAP -0.30608004962895 3.25721913642118e-11 NA NA NA hsa-miR-29c-3p CCND1 -0.372180390387259 0.00202634431973208 0.517304800763483 1.04046594178888e-06 mirMAP -0.263497298429692 1.34805822955252e-11 NA NA NA hsa-miR-3065-5p CCND1 -0.262608140481507 0.0414570974148034 0.517304800763483 1.04046594178888e-06 mirMAP -0.105747126080182 0.00178155205723976 NA NA NA hsa-miR-330-3p CCND1 -0.427388106938151 0.00300489284414266 0.517304800763483 1.04046594178888e-06 mirMAP -0.156757729272097 1.33987981854083e-07 NA NA NA hsa-miR-338-3p CCND1 -0.39963704679384 0.0034410643220691 0.517304800763483 1.04046594178888e-06 miRNAWalker2_validate;miRTarBase;miRanda -0.138060683824931 7.24806702911648e-05 NA NA NA hsa-miR-34a-5p CCND1 0.143472919835524 0.211283228567057 0.517304800763483 1.04046594178888e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.176667405034615 4.78965946188406e-06 25792709;21399894 This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a ; liver cancer;breast cancer hsa-miR-365a-3p CCND1 -0.184222766207919 0.0292663235724171 0.517304800763483 1.04046594178888e-06 miRNAWalker2_validate;miRTarBase -0.195991913128339 0.000198680829195249 NA NA NA hsa-miR-425-5p CCND1 -0.0412837711174561 0.682284485592858 0.517304800763483 1.04046594178888e-06 miRNAWalker2_validate -0.134644465621285 0.00325561137510874 NA NA NA hsa-miR-490-3p CCND1 -0.834268051506884 5.26203010743215e-06 0.517304800763483 1.04046594178888e-06 miRanda -0.131117175699242 2.90415525218072e-08 24440705 MicroRNA 490 3p inhibits proliferation of A549 lung cancer cells by targeting CCND1; We also found that forced expression of miR-490-3P decreased both mRNA and protein levels of CCND1 which plays a key role in G1/S phase transition; In addition the dual-luciferase reporter assays indicated that miR-490-3P directly targets CCND1 through binding its 3'UTR lung cancer hsa-miR-495-3p CCND1 -0.421982588962504 0.00504424038526901 0.517304800763483 1.04046594178888e-06 MirTarget -0.136090131725584 2.1911780731285e-06 NA NA NA hsa-miR-7-1-3p CCND1 -0.0894475316162393 0.37322359785108 0.517304800763483 1.04046594178888e-06 mirMAP -0.241924898170475 2.08913227927897e-08 NA NA NA hsa-miR-769-3p CCND1 -0.287263649023213 0.018145224330845 0.517304800763483 1.04046594178888e-06 mirMAP -0.276564457533319 1.97356475814615e-15 NA NA NA hsa-miR-885-5p CCND1 -0.423614695846868 1.14213289528402e-05 0.517304800763483 1.04046594178888e-06 miRNATAP -0.292419966156513 1.08197956283879e-10 NA NA NA hsa-let-7b-3p CCND2 -0.00495618733298731 0.952288980686967 0.278072058804804 0.00230941164668614 mirMAP -0.124812140552693 0.00599796857804289 NA NA NA hsa-let-7f-1-3p CCND2 0.110713086694053 0.21484524300518 0.278072058804804 0.00230941164668614 mirMAP -0.122537465829283 0.00233902672067921 NA NA NA hsa-let-7g-5p CCND2 -0.0253396334608382 0.742556489443668 0.278072058804804 0.00230941164668614 miRNATAP -0.196434601966773 0.0012996932102575 NA NA NA hsa-let-7i-5p CCND2 0.0952853587923244 0.192120688957249 0.278072058804804 0.00230941164668614 miRNATAP -0.162156277541767 0.00988534673137717 NA NA NA hsa-miR-129-5p CCND2 -0.567133990117126 0.00116152215679936 0.278072058804804 0.00230941164668614 mirMAP -0.105272286982926 4.44505393807218e-07 NA NA NA hsa-miR-145-3p CCND2 0.110543172922298 0.294150620210019 0.278072058804804 0.00230941164668614 mirMAP -0.149944712694934 9.82587587919985e-06 NA NA NA hsa-miR-145-5p CCND2 0.108948399943015 0.310032352776693 0.278072058804804 0.00230941164668614 miRNATAP -0.155654659327631 1.04593167784463e-05 NA NA NA hsa-miR-146b-3p CCND2 0.283486177568242 0.0118918188864879 0.278072058804804 0.00230941164668614 MirTarget;PITA;miRNATAP -0.117766891479947 0.000283548163350027 NA NA NA hsa-miR-150-5p CCND2 0.0645271721519611 0.513295658828718 0.278072058804804 0.00230941164668614 mirMAP -0.149451068560082 7.57763104304709e-05 NA NA NA hsa-miR-151a-3p CCND2 0.0336074122085215 0.726834677736803 0.278072058804804 0.00230941164668614 mirMAP -0.12420907434582 0.00497911559673839 NA NA NA hsa-miR-185-5p CCND2 -0.0767432095218297 0.404113540276816 0.278072058804804 0.00230941164668614 MirTarget;miRNATAP -0.183398276514872 8.3630357382723e-06 NA NA NA hsa-miR-186-5p CCND2 0.0606381894130505 0.514217717592464 0.278072058804804 0.00230941164668614 mirMAP;miRNATAP -0.133720175872038 0.00173369326890833 NA NA NA hsa-miR-191-5p CCND2 0.0973986771912738 0.220078671774056 0.278072058804804 0.00230941164668614 MirTarget -0.20451499794437 0.00023723661594718 NA NA NA hsa-miR-26a-5p CCND2 0.033823776747294 0.726610414342369 0.278072058804804 0.00230941164668614 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.122521188171157 0.00669669430395561 NA NA NA hsa-miR-26b-5p CCND2 -0.0984536538762768 0.231803769574623 0.278072058804804 0.00230941164668614 mirMAP;miRNATAP -0.21765809461179 3.01296451472833e-05 NA NA NA hsa-miR-28-5p CCND2 0.104003572105781 0.153594705579534 0.278072058804804 0.00230941164668614 miRanda -0.151040812510917 0.00458703218164268 NA NA NA hsa-miR-29a-3p CCND2 -0.224140851576083 0.0349516103550236 0.278072058804804 0.00230941164668614 MirTarget;miRNATAP -0.199711571525784 5.61968185759315e-06 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-29a-5p CCND2 -0.0697727833812678 0.350621682973119 0.278072058804804 0.00230941164668614 mirMAP -0.166759307844904 0.000688470083956136 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-29b-3p CCND2 -0.178522712044497 0.0856106432165465 0.278072058804804 0.00230941164668614 MirTarget;miRNATAP -0.202303651104096 1.45292987304036e-07 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-29c-3p CCND2 -0.372180390387259 0.00202634431973208 0.278072058804804 0.00230941164668614 MirTarget;miRNATAP -0.239386359038839 8.64180673949139e-14 NA NA NA hsa-miR-30d-3p CCND2 0.0854049347792898 0.20691254801121 0.278072058804804 0.00230941164668614 mirMAP -0.155355754639963 0.00382748112364014 NA NA NA hsa-miR-30e-3p CCND2 0.00173769765874887 0.984965501547409 0.278072058804804 0.00230941164668614 mirMAP -0.268522462794922 4.02496537819957e-07 NA NA NA hsa-miR-324-3p CCND2 -0.0103367134443655 0.904494071318044 0.278072058804804 0.00230941164668614 miRNAWalker2_validate -0.184828101121747 1.93642919504512e-05 NA NA NA hsa-miR-331-5p CCND2 0.00538076980695534 0.942833685963252 0.278072058804804 0.00230941164668614 miRNATAP -0.168360380366874 0.000470859110297375 NA NA NA hsa-miR-33a-3p CCND2 -0.158366376619191 0.0991512910387226 0.278072058804804 0.00230941164668614 MirTarget -0.10197096016646 0.00681801603426165 NA NA NA hsa-miR-3622a-3p CCND2 0.0389203848593471 0.75605812962459 0.278072058804804 0.00230941164668614 mirMAP -0.125163354365051 1.78891207109425e-05 NA NA NA hsa-miR-488-3p CCND2 -0.257955761012568 0.00280795162806256 0.278072058804804 0.00230941164668614 mirMAP -0.183392273105331 1.52514393662224e-05 NA NA NA hsa-miR-488-5p CCND2 -0.385755602369049 7.99431673275965e-08 0.278072058804804 0.00230941164668614 mirMAP -0.153852506035559 0.00315722783501446 NA NA NA hsa-miR-500a-5p CCND2 0.0634452729978863 0.396072382601677 0.278072058804804 0.00230941164668614 mirMAP -0.155381019814906 0.0013241335866013 NA NA NA hsa-miR-501-5p CCND2 0.0878951859817452 0.309663377222443 0.278072058804804 0.00230941164668614 PITA;mirMAP;miRNATAP -0.110941849752897 0.00801840144207187 NA NA NA hsa-miR-660-5p CCND2 -0.138989893523975 0.0945491063873448 0.278072058804804 0.00230941164668614 mirMAP -0.238701834193771 2.94573193719288e-07 NA NA NA hsa-miR-7-1-3p CCND2 -0.0894475316162393 0.37322359785108 0.278072058804804 0.00230941164668614 mirMAP -0.150925481137646 2.69591030726187e-05 NA NA NA hsa-miR-155-5p CHD8 0.969837380981085 5.86551495710056e-15 -0.0724972430040607 0.164913657377879 miRNATAP -0.118819659835116 2.5878707761315e-25 NA NA NA hsa-miR-221-3p CHD8 -0.0109507285071775 0.936440693394519 -0.0724972430040607 0.164913657377879 MirTarget;miRNATAP -0.101710506305759 5.97062661724688e-21 NA NA NA hsa-miR-222-3p CHD8 0.107117065575197 0.423818119725697 -0.0724972430040607 0.164913657377879 MirTarget;miRNATAP -0.104867165539355 7.74612296403587e-22 NA NA NA hsa-miR-2355-5p CHD8 0.00808596988211185 0.916165501155096 -0.0724972430040607 0.164913657377879 MirTarget;miRNATAP -0.148403951744356 4.6518595917021e-13 NA NA NA hsa-miR-365a-3p CHD8 -0.184222766207919 0.0292663235724171 -0.0724972430040607 0.164913657377879 miRNATAP -0.14480140470638 1.09017440141414e-15 NA NA NA hsa-miR-484 CHD8 -0.0190828819137732 0.802298900989652 -0.0724972430040607 0.164913657377879 PITA;miRNATAP -0.104782884992638 9.46520785797311e-07 NA NA NA hsa-let-7e-5p CREBBP 0.0471189209570344 0.657255455444655 -0.047978601693571 0.404366818323115 miRNAWalker2_validate -0.117826371466181 2.40828040481683e-09 NA NA NA hsa-miR-1301-3p CREBBP -0.105695714210758 0.152249184194132 -0.047978601693571 0.404366818323115 miRNAWalker2_validate -0.145041633909724 7.95662975669671e-09 NA NA NA hsa-miR-142-5p CREBBP 0.434884875454107 0.000575570345702788 -0.047978601693571 0.404366818323115 mirMAP -0.106025113337559 1.85000672571322e-14 NA NA NA hsa-miR-186-5p CREBBP 0.0606381894130505 0.514217717592464 -0.047978601693571 0.404366818323115 mirMAP;miRNATAP -0.147890785462563 1.79437968717686e-12 NA NA NA hsa-miR-200b-3p CREBBP 0.245768526504511 0.0580744465744737 -0.047978601693571 0.404366818323115 mirMAP -0.123048999824309 2.44260177280472e-19 NA NA NA hsa-miR-200c-3p CREBBP 0.413752622631695 8.6936333715621e-06 -0.047978601693571 0.404366818323115 mirMAP -0.133825633175237 1.58816104033339e-12 NA NA NA hsa-miR-26a-5p CREBBP 0.033823776747294 0.726610414342369 -0.047978601693571 0.404366818323115 miRNATAP -0.116054995750247 2.26207553528174e-07 NA NA NA hsa-miR-26b-5p CREBBP -0.0984536538762768 0.231803769574623 -0.047978601693571 0.404366818323115 miRNATAP -0.164373734995276 2.00260444141814e-10 NA NA NA hsa-miR-30a-3p CREBBP 0.0655410309550977 0.509541256241954 -0.047978601693571 0.404366818323115 MirTarget;miRNATAP -0.118406533193908 4.53827599405547e-07 NA NA NA hsa-miR-30e-3p CREBBP 0.00173769765874887 0.984965501547409 -0.047978601693571 0.404366818323115 MirTarget -0.140461173361411 1.16147592773995e-07 NA NA NA hsa-miR-361-5p CREBBP 0.0107519600643302 0.882230614095565 -0.047978601693571 0.404366818323115 PITA;miRanda;miRNATAP -0.20977112720493 4.42799460550161e-12 NA NA NA hsa-miR-374a-3p CREBBP 0.176226170437625 0.0343958848425446 -0.047978601693571 0.404366818323115 miRNATAP -0.166006934673094 4.57407449473457e-10 NA NA NA hsa-miR-548b-3p CREBBP 0.340474544210108 0.00224491592019745 -0.047978601693571 0.404366818323115 miRNATAP -0.122339265277455 1.92040117401605e-14 NA NA NA hsa-miR-590-3p CREBBP 0.312951515438396 0.000480455423843996 -0.047978601693571 0.404366818323115 PITA;miRanda;mirMAP;miRNATAP -0.145167352998136 1.52352483162506e-13 NA NA NA hsa-miR-628-3p CREBBP -0.243661425878074 0.0594758496279051 -0.047978601693571 0.404366818323115 PITA -0.103726817505493 6.28819709328743e-14 NA NA NA hsa-miR-30b-5p CSNK1A1 -0.0858101016322106 0.263243418521854 0.0336954895203005 0.48195201763547 MirTarget;mirMAP;miRNATAP -0.102687707950832 7.00746484921216e-12 NA NA NA hsa-miR-125a-3p CSNK1E 0.183834985432376 0.106230647107917 -0.146354129749598 0.0307632357387562 miRanda -0.15961978903297 4.01558528014413e-17 NA NA NA hsa-miR-140-5p CSNK1E 0.065063507103468 0.380452509211773 -0.146354129749598 0.0307632357387562 miRanda -0.142693673489977 8.37451948951825e-06 NA NA NA hsa-miR-149-5p CSNK1E -0.0535821592029952 0.657713892012548 -0.146354129749598 0.0307632357387562 miRNAWalker2_validate -0.173703033156197 1.99700568380504e-22 NA NA NA hsa-miR-22-5p CSNK1E 0.0437233965539527 0.639996108995995 -0.146354129749598 0.0307632357387562 miRNATAP -0.304774400755045 5.94523476875606e-44 NA NA NA hsa-miR-30a-3p CSNK1E 0.0655410309550977 0.509541256241954 -0.146354129749598 0.0307632357387562 miRNATAP -0.305267422461947 5.74087627339189e-29 NA NA NA hsa-miR-30c-5p CSNK1E -0.0469114469943097 0.565934557464627 -0.146354129749598 0.0307632357387562 miRNAWalker2_validate -0.296010343904598 1.30193544783009e-18 NA NA NA hsa-miR-30d-3p CSNK1E 0.0854049347792898 0.20691254801121 -0.146354129749598 0.0307632357387562 miRNATAP -0.202863679086823 3.50537302214817e-10 NA NA NA hsa-miR-320c CSNK1E 0.343259124189966 0.000248338401291051 -0.146354129749598 0.0307632357387562 miRanda;miRNATAP -0.111144011611044 3.44280358053022e-06 NA NA NA hsa-miR-362-3p CSNK1E 0.032375035235532 0.736465332563774 -0.146354129749598 0.0307632357387562 miRanda -0.162043640196434 5.14773042428326e-13 NA NA NA hsa-miR-375 CSNK1E -0.0268401141324031 0.858358101444697 -0.146354129749598 0.0307632357387562 miRanda -0.102585183906355 5.91855517798681e-13 NA NA NA hsa-miR-590-3p CSNK1E 0.312951515438396 0.000480455423843996 -0.146354129749598 0.0307632357387562 miRanda -0.164422125892365 8.30551781892932e-12 NA NA NA hsa-miR-125a-5p CSNK2A1 -0.0833349424517387 0.325440200253607 0.0198775240211866 0.674286059482808 MirTarget;PITA;miRanda -0.115125762662118 1.14856769250436e-08 NA NA NA hsa-miR-186-5p CSNK2A1 0.0606381894130505 0.514217717592464 0.0198775240211866 0.674286059482808 miRNAWalker2_validate;mirMAP;miRNATAP -0.104450848571426 1.78690585033463e-10 NA NA NA hsa-miR-22-3p CSNK2A1 0.0277287593466351 0.809325106832648 0.0198775240211866 0.674286059482808 miRNAWalker2_validate -0.103111897698292 6.07931470086042e-10 NA NA NA hsa-miR-26b-5p CSNK2A1 -0.0984536538762768 0.231803769574623 0.0198775240211866 0.674286059482808 mirMAP -0.114571306404055 1.32771587467342e-08 NA NA NA hsa-miR-488-3p CSNK2B -0.257955761012568 0.00280795162806256 0.036955235096654 0.458986884078576 miRNATAP -0.108167004743662 1.34808391194492e-10 NA NA NA hsa-let-7f-1-3p CTBP2 0.110713086694053 0.21484524300518 -0.200717956151272 9.39078162124122e-05 mirMAP -0.123635033524006 2.81525053869263e-11 NA NA NA hsa-miR-146b-5p CTBP2 0.441078059667297 0.000237619929889385 -0.200717956151272 9.39078162124122e-05 miRanda -0.172671943665044 2.98027985474638e-36 NA NA NA hsa-miR-200b-3p CTBP2 0.245768526504511 0.0580744465744737 -0.200717956151272 9.39078162124122e-05 TargetScan -0.100189482289038 9.93585528445471e-15 NA NA NA hsa-miR-590-3p CTBP2 0.312951515438396 0.000480455423843996 -0.200717956151272 9.39078162124122e-05 PITA;miRanda -0.123841792236004 2.14669915677024e-11 NA NA NA hsa-let-7a-3p CTNNB1 0.0530563276543763 0.370749834463566 0.0357918808324289 0.517099644291201 MirTarget;miRNATAP -0.100275934552221 7.48576342515523e-05 NA NA NA hsa-let-7a-2-3p CXXC4 0.295235553592458 0.00290654476250609 -0.279307540200037 0.0150265027423186 MirTarget -0.161853991504063 0.00159426190925631 NA NA NA hsa-let-7f-1-3p CXXC4 0.110713086694053 0.21484524300518 -0.279307540200037 0.0150265027423186 mirMAP -0.184690288611523 0.000990592287568255 NA NA NA hsa-miR-141-3p CXXC4 0.41120561991992 0.000393344390969055 -0.279307540200037 0.0150265027423186 TargetScan -0.33450778308078 6.10837963938262e-15 NA NA NA hsa-miR-146a-5p CXXC4 0.148942451196282 0.114229072828724 -0.279307540200037 0.0150265027423186 MirTarget -0.163013657305209 0.00248012883346096 NA NA NA hsa-miR-146b-5p CXXC4 0.441078059667297 0.000237619929889385 -0.279307540200037 0.0150265027423186 MirTarget;miRNATAP -0.447633101286159 5.45901236111102e-27 NA NA NA hsa-miR-148a-3p CXXC4 0.306821592493439 0.0392356958885949 -0.279307540200037 0.0150265027423186 miRNATAP -0.310555862111421 1.43494399587627e-19 NA NA NA hsa-miR-186-5p CXXC4 0.0606381894130505 0.514217717592464 -0.279307540200037 0.0150265027423186 mirMAP -0.352029386383273 2.10671579685667e-09 NA NA NA hsa-miR-190a-5p CXXC4 -0.0574993923869409 0.534047621516133 -0.279307540200037 0.0150265027423186 MirTarget -0.28768356810441 9.17252423844435e-08 NA NA NA hsa-miR-21-5p CXXC4 1.0504925175311 2.58081295984106e-11 -0.279307540200037 0.0150265027423186 mirMAP -0.310894888079927 2.44175551744163e-19 NA NA NA hsa-miR-223-3p CXXC4 -0.0272428307560952 0.814395950305568 -0.279307540200037 0.0150265027423186 MirTarget -0.327462570329511 6.57853145193245e-14 NA NA NA hsa-miR-30a-3p CXXC4 0.0655410309550977 0.509541256241954 -0.279307540200037 0.0150265027423186 mirMAP -0.321200046577963 8.94829559163848e-07 NA NA NA hsa-miR-30e-3p CXXC4 0.00173769765874887 0.984965501547409 -0.279307540200037 0.0150265027423186 mirMAP -0.382326246419727 2.22924952346355e-07 NA NA NA hsa-miR-452-5p CXXC4 0.599327068454211 1.02031931068531e-05 -0.279307540200037 0.0150265027423186 miRNATAP -0.265401929291625 1.17124552820386e-13 NA NA NA hsa-miR-501-5p CXXC4 0.0878951859817452 0.309663377222443 -0.279307540200037 0.0150265027423186 mirMAP -0.430587093454725 4.06268130505246e-14 NA NA NA hsa-miR-532-5p CXXC4 0.0263466708637097 0.75763006039876 -0.279307540200037 0.0150265027423186 MirTarget;PITA;miRNATAP -0.332330788687575 3.19740272344971e-06 NA NA NA hsa-miR-576-5p CXXC4 0.106482276040047 0.194379152564166 -0.279307540200037 0.0150265027423186 mirMAP -0.395851063993138 8.87751832403513e-11 NA NA NA hsa-miR-589-5p CXXC4 -0.0382528919634639 0.5844074434222 -0.279307540200037 0.0150265027423186 MirTarget;miRNATAP -0.423347706790244 3.23327588382336e-07 NA NA NA hsa-miR-590-3p CXXC4 0.312951515438396 0.000480455423843996 -0.279307540200037 0.0150265027423186 mirMAP -0.357177479223387 8.58690672447855e-11 NA NA NA hsa-miR-590-5p CXXC4 0.16946027035949 0.0386004382081678 -0.279307540200037 0.0150265027423186 mirMAP -0.31683539100664 2.50824083457224e-07 NA NA NA hsa-miR-660-5p CXXC4 -0.138989893523975 0.0945491063873448 -0.279307540200037 0.0150265027423186 miRNATAP -0.378707321313216 4.70309114700533e-09 NA NA NA hsa-miR-664a-3p CXXC4 0.0413918462467198 0.611334357897022 -0.279307540200037 0.0150265027423186 mirMAP -0.586810542711044 5.42508051920587e-22 NA NA NA hsa-miR-7-1-3p CXXC4 -0.0894475316162393 0.37322359785108 -0.279307540200037 0.0150265027423186 mirMAP -0.143159441184782 0.00446198704934396 NA NA NA hsa-miR-708-3p CXXC4 0.00458267260363954 0.962455132950708 -0.279307540200037 0.0150265027423186 MirTarget -0.232298098697753 5.16261420879115e-05 NA NA NA hsa-miR-19a-3p DAAM1 0.0466707843731911 0.576818938277755 -0.0438780352762951 0.599941296999868 miRNATAP -0.180362885546849 4.54949709843923e-05 NA NA NA hsa-miR-19b-3p DAAM1 -0.0138427450847924 0.856506310673067 -0.0438780352762951 0.599941296999868 miRNATAP -0.279698756569986 9.53952715327351e-08 NA NA NA hsa-miR-144-5p DAAM2 0.0784834905249552 0.620720209395281 -1.01407163086171 1.52082347806246e-13 mirMAP -0.119549411510886 0.00131802705225922 NA NA NA hsa-miR-146b-5p DAAM2 0.441078059667297 0.000237619929889385 -1.01407163086171 1.52082347806246e-13 miRanda -0.337092097728105 1.33275166613546e-11 NA NA NA hsa-miR-18a-5p DAAM2 0.175320895022849 0.0732549187136286 -1.01407163086171 1.52082347806246e-13 miRNAWalker2_validate -0.238990480975567 5.12254314367303e-05 NA NA NA hsa-miR-193a-3p DAAM2 0.395602305834739 0.00182611787714301 -1.01407163086171 1.52082347806246e-13 miRanda -0.130506579697435 0.00524552444975825 NA NA NA hsa-miR-19b-3p DAAM2 -0.0138427450847924 0.856506310673067 -1.01407163086171 1.52082347806246e-13 miRNAWalker2_validate -0.456444852014757 1.15003250244742e-07 NA NA NA hsa-miR-590-3p DAAM2 0.312951515438396 0.000480455423843996 -1.01407163086171 1.52082347806246e-13 miRanda;mirMAP -0.192212932655571 0.00301832193921066 NA NA NA hsa-miR-592 DAAM2 0.0170005651576508 0.876633091134809 -1.01407163086171 1.52082347806246e-13 mirMAP -0.366032187107652 2.36950665868795e-12 NA NA NA hsa-miR-125a-5p DVL2 -0.0833349424517387 0.325440200253607 0.0902324037547402 0.0682410453231654 miRanda -0.250053970863593 4.38364779426917e-27 NA NA NA hsa-miR-221-3p DVL2 -0.0109507285071775 0.936440693394519 0.0902324037547402 0.0682410453231654 miRNAWalker2_validate -0.163493026730553 5.15035042493694e-48 21487968 MiR 221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2; We also suggest that miR-221 may control the migration of AIPC cells through DVL2 working as a key regulator in advanced CaP staging prostate cancer hsa-miR-27a-3p DVL2 0.303760032895792 0.00457375391189806 0.0902324037547402 0.0682410453231654 miRNATAP -0.110653456750655 2.82256030954912e-11 NA NA NA hsa-miR-27b-3p DVL2 -0.0599187745243146 0.58208143475992 0.0902324037547402 0.0682410453231654 miRNATAP -0.172378042250817 1.97856606604285e-26 NA NA NA hsa-miR-28-5p DVL2 0.104003572105781 0.153594705579534 0.0902324037547402 0.0682410453231654 miRanda -0.138180149807161 1.75779834392017e-08 NA NA NA hsa-miR-324-3p DVL2 -0.0103367134443655 0.904494071318044 0.0902324037547402 0.0682410453231654 miRNAWalker2_validate -0.196439931572551 3.33370675639798e-24 NA NA NA hsa-miR-484 DVL2 -0.0190828819137732 0.802298900989652 0.0902324037547402 0.0682410453231654 miRNAWalker2_validate -0.208315082621615 6.40977890057117e-20 NA NA NA hsa-miR-590-5p DVL2 0.16946027035949 0.0386004382081678 0.0902324037547402 0.0682410453231654 miRanda -0.110742788759619 6.49339363263657e-08 NA NA NA hsa-miR-125a-5p DVL3 -0.0833349424517387 0.325440200253607 0.00939128799229039 0.857704514389324 PITA -0.204674238146054 1.44001112830151e-25 NA NA NA hsa-miR-146b-3p DVL3 0.283486177568242 0.0118918188864879 0.00939128799229039 0.857704514389324 MirTarget -0.140794980429694 7.5789655726664e-32 NA NA NA hsa-miR-150-5p DVL3 0.0645271721519611 0.513295658828718 0.00939128799229039 0.857704514389324 MirTarget -0.112833710820738 6.55890443518558e-15 NA NA NA hsa-miR-24-3p DVL3 0.133257261462871 0.212960921400853 0.00939128799229039 0.857704514389324 MirTarget -0.12563498092013 7.08723079700699e-19 NA NA NA hsa-miR-26b-5p DVL3 -0.0984536538762768 0.231803769574623 0.00939128799229039 0.857704514389324 miRNAWalker2_validate -0.136713834505188 1.17845971341915e-11 NA NA NA hsa-miR-29b-2-5p DVL3 -0.26834261955727 0.00453760540520233 0.00939128799229039 0.857704514389324 MirTarget -0.214484906185934 8.22295585996424e-56 NA NA NA hsa-miR-30a-3p DVL3 0.0655410309550977 0.509541256241954 0.00939128799229039 0.857704514389324 MirTarget -0.10131636262252 3.14407615402404e-08 NA NA NA hsa-miR-30e-3p DVL3 0.00173769765874887 0.984965501547409 0.00939128799229039 0.857704514389324 MirTarget -0.197182284592209 9.03229480303599e-23 NA NA NA hsa-miR-330-5p DVL3 -0.262932095995605 0.0465226565966658 0.00939128799229039 0.857704514389324 miRNATAP -0.110031511252826 2.03459869563188e-27 NA NA NA hsa-miR-331-5p DVL3 0.00538076980695534 0.942833685963252 0.00939128799229039 0.857704514389324 PITA;miRNATAP -0.13859874287227 6.14771531743775e-14 NA NA NA hsa-miR-590-5p DVL3 0.16946027035949 0.0386004382081678 0.00939128799229039 0.857704514389324 mirMAP -0.12398843317908 3.52514817672704e-13 NA NA NA hsa-miR-671-5p DVL3 0.379677704170736 0.000129391032677459 0.00939128799229039 0.857704514389324 MirTarget;PITA;miRNATAP -0.110557554277412 7.27891622463238e-16 NA NA NA hsa-miR-149-5p EP300 -0.0535821592029952 0.657713892012548 -0.0809024456519438 0.228129652996621 miRNAWalker2_validate -0.118369420853507 3.40308138671425e-09 NA NA NA hsa-miR-186-5p EP300 0.0606381894130505 0.514217717592464 -0.0809024456519438 0.228129652996621 miRNATAP -0.120697160730751 2.08389735806641e-05 NA NA NA hsa-miR-200b-3p EP300 0.245768526504511 0.0580744465744737 -0.0809024456519438 0.228129652996621 miRNAWalker2_validate;TargetScan -0.113063865997244 1.22732110177343e-09 NA NA NA hsa-miR-200c-3p EP300 0.413752622631695 8.6936333715621e-06 -0.0809024456519438 0.228129652996621 miRNAWalker2_validate;miRNATAP -0.154403328800266 1.16945030241261e-09 NA NA NA hsa-miR-22-3p EP300 0.0277287593466351 0.809325106832648 -0.0809024456519438 0.228129652996621 MirTarget;miRNATAP -0.129040932214718 7.43865109883095e-06 NA NA NA hsa-miR-2355-3p EP300 0.186207523505296 0.0525918026993012 -0.0809024456519438 0.228129652996621 MirTarget;miRNATAP -0.10892387366383 1.09126064579299e-05 NA NA NA hsa-miR-26b-5p EP300 -0.0984536538762768 0.231803769574623 -0.0809024456519438 0.228129652996621 miRNAWalker2_validate;miRNATAP -0.146408928599053 2.57076047853747e-05 NA NA NA hsa-miR-29b-1-5p EP300 0.191335428755774 0.00846436454790702 -0.0809024456519438 0.228129652996621 MirTarget -0.110260412848281 0.000822430640380143 NA NA NA hsa-miR-30c-5p EP300 -0.0469114469943097 0.565934557464627 -0.0809024456519438 0.228129652996621 miRNAWalker2_validate -0.312468973887759 2.06637782937568e-17 NA NA NA hsa-miR-339-5p EP300 0.273253751377152 0.0185300170790638 -0.0809024456519438 0.228129652996621 miRanda -0.139872022902314 5.63823302029633e-12 NA NA NA hsa-miR-342-3p EP300 -0.125683829770877 0.105810751640137 -0.0809024456519438 0.228129652996621 MirTarget;PITA;miRanda;miRNATAP -0.186971239869884 5.16619501373405e-08 NA NA NA hsa-miR-361-3p EP300 -0.0798653643614555 0.271064714084553 -0.0809024456519438 0.228129652996621 PITA -0.179432283394391 1.94960435203698e-06 NA NA NA hsa-miR-574-3p EP300 0.254057161073935 0.0219522676746007 -0.0809024456519438 0.228129652996621 PITA -0.118613580916583 3.76846499771262e-08 NA NA NA hsa-miR-590-3p EP300 0.312951515438396 0.000480455423843996 -0.0809024456519438 0.228129652996621 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.112448802446131 2.42909707997915e-05 NA NA NA hsa-miR-200c-3p FBXW11 0.413752622631695 8.6936333715621e-06 -0.209443489586462 3.82268852067728e-05 MirTarget;miRNATAP -0.124772244040868 5.05927874520419e-17 NA NA NA hsa-miR-320a FBXW11 0.092135599636725 0.243028758989929 -0.209443489586462 3.82268852067728e-05 PITA;miRanda -0.115403583004013 2.89270418758212e-07 NA NA NA hsa-miR-93-5p FBXW11 0.139766237971122 0.101057320076629 -0.209443489586462 3.82268852067728e-05 miRNATAP -0.188583431461378 9.68623062711781e-14 NA NA NA hsa-miR-138-5p FOSL1 -0.616087649920851 1.35200027885729e-05 1.03487462222003 4.87762882989878e-12 miRTarBase -0.284692328939477 1.19315764301941e-09 NA NA NA hsa-miR-326 FOSL1 -0.631050656251074 8.83643450601471e-05 1.03487462222003 4.87762882989878e-12 miRanda -0.177104671863143 1.59140366007354e-05 NA NA NA hsa-miR-199b-5p FRAT1 0.436298593972862 0.00200225454383871 -0.236979132752767 0.00251960460487315 miRanda -0.114402025436554 8.68929862472988e-07 NA NA NA hsa-miR-23b-3p FRAT1 0.0476610245860094 0.630277683372344 -0.236979132752767 0.00251960460487315 miRNATAP -0.194610660179166 1.88629275580684e-07 NA NA NA hsa-miR-30a-3p FRAT1 0.0655410309550977 0.509541256241954 -0.236979132752767 0.00251960460487315 miRNATAP -0.260511174929853 1.53612197048921e-09 NA NA NA hsa-miR-30d-3p FRAT1 0.0854049347792898 0.20691254801121 -0.236979132752767 0.00251960460487315 miRNATAP -0.164786957447491 0.000898598712260742 NA NA NA hsa-miR-150-5p FRAT2 0.0645271721519611 0.513295658828718 -0.124005270786558 0.0151727061914524 miRNATAP -0.121685780548545 6.20196105937046e-09 NA NA NA hsa-miR-22-3p FRAT2 0.0277287593466351 0.809325106832648 -0.124005270786558 0.0151727061914524 miRNAWalker2_validate;MirTarget;miRNATAP -0.172216569406783 4.42709233584143e-13 NA NA NA hsa-miR-222-3p FRAT2 0.107117065575197 0.423818119725697 -0.124005270786558 0.0151727061914524 miRNATAP -0.1054338415541 6.5118809505275e-13 NA NA NA hsa-miR-23a-3p FRAT2 0.334693010651106 0.00144448147063433 -0.124005270786558 0.0151727061914524 miRNATAP -0.112365725274631 2.00637861973609e-07 NA NA NA hsa-miR-23b-3p FRAT2 0.0476610245860094 0.630277683372344 -0.124005270786558 0.0151727061914524 miRNATAP -0.146726782717359 5.92040741969567e-11 NA NA NA hsa-miR-26a-5p FRAT2 0.033823776747294 0.726610414342369 -0.124005270786558 0.0151727061914524 miRNATAP -0.102997974101647 4.23554767841652e-05 NA NA NA hsa-miR-532-3p FRAT2 0.150624483952741 0.0599635132177191 -0.124005270786558 0.0151727061914524 miRNATAP -0.106739041033202 3.98163948216139e-05 NA NA NA hsa-miR-885-5p FZD10 -0.423614695846868 1.14213289528402e-05 0.417962484057116 2.71159524221683e-05 miRNATAP -0.176008636626402 0.000146213618242937 NA NA NA hsa-miR-92b-3p FZD10 -0.213968504161963 0.0523921855715716 0.417962484057116 2.71159524221683e-05 miRNATAP -0.224562819944926 1.07680006304021e-06 NA NA NA hsa-let-7a-3p FZD3 0.0530563276543763 0.370749834463566 0.0381563660178239 0.555379368586633 MirTarget;miRNATAP -0.316955234728556 5.20384316329794e-10 NA NA NA hsa-miR-19a-3p FZD3 0.0466707843731911 0.576818938277755 0.0381563660178239 0.555379368586633 mirMAP -0.114296703890047 0.000852808934936181 NA NA NA hsa-miR-19b-3p FZD3 -0.0138427450847924 0.856506310673067 0.0381563660178239 0.555379368586633 mirMAP -0.255395893701152 2.31053011826599e-10 NA NA NA hsa-miR-20a-5p FZD3 -0.0115865752288853 0.887069448776018 0.0381563660178239 0.555379368586633 MirTarget;mirMAP;miRNATAP -0.11981691497988 0.00298311168929979 NA NA NA hsa-miR-30b-5p FZD3 -0.0858101016322106 0.263243418521854 0.0381563660178239 0.555379368586633 MirTarget -0.226160629040013 1.15032655004707e-07 NA NA NA hsa-miR-454-3p FZD3 0.177318549827649 0.0120865170334418 0.0381563660178239 0.555379368586633 mirMAP -0.123263236420706 0.0023033717800418 NA NA NA hsa-miR-9-3p FZD3 -0.184945845984695 0.0290051908009009 0.0381563660178239 0.555379368586633 mirMAP -0.28682073868722 3.25426992144764e-11 NA NA NA hsa-miR-454-3p FZD4 0.177318549827649 0.0120865170334418 0.0863652748594239 0.124438370849895 mirMAP -0.100478780737487 0.00174340730785198 NA NA NA hsa-miR-508-3p FZD5 -0.292045725850845 0.0158994578296519 0.263265623395583 0.0001553303065478 miRNATAP -0.123981883174627 4.02919043561776e-07 NA NA NA hsa-miR-767-5p FZD5 -0.551653504513145 2.61109058244854e-05 0.263265623395583 0.0001553303065478 miRNATAP -0.216872483247104 1.96380778787551e-22 NA NA NA hsa-miR-9-5p FZD5 -0.125377971246422 0.269896477802284 0.263265623395583 0.0001553303065478 MirTarget -0.607507416412689 8.47607042792454e-22 NA NA NA hsa-miR-1-3p FZD7 -0.218035884810576 0.125196862509753 -0.143353841507968 0.287910445488918 MirTarget -0.142875571015404 0.000408094268281321 NA NA NA hsa-miR-105-5p FZD7 -0.567459149851677 8.20858944634795e-06 -0.143353841507968 0.287910445488918 miRNATAP -0.377936140040983 4.54850905247271e-17 NA NA NA hsa-miR-130b-5p FZD7 0.413070888963592 1.98866876365509e-06 -0.143353841507968 0.287910445488918 mirMAP -0.209135471980149 0.00236449443329202 NA NA NA hsa-miR-145-5p FZD7 0.108948399943015 0.310032352776693 -0.143353841507968 0.287910445488918 miRNAWalker2_validate;MirTarget;miRNATAP -0.197107076335715 0.000562270932866465 NA NA NA hsa-miR-192-5p FZD7 -0.0426540615456616 0.621616927627554 -0.143353841507968 0.287910445488918 miRNAWalker2_validate -0.212566611926992 0.00665974318465403 NA NA NA hsa-miR-20a-5p FZD7 -0.0115865752288853 0.887069448776018 -0.143353841507968 0.287910445488918 miRNATAP -0.296665272480083 0.000515124824009724 NA NA NA hsa-miR-338-3p FZD7 -0.39963704679384 0.0034410643220691 -0.143353841507968 0.287910445488918 miRanda -0.137166244355571 0.00323076033200257 NA NA NA hsa-miR-135a-5p GSK3B -0.122734612943241 0.196985964641886 -0.00812669327682514 0.891858643750953 miRNATAP -0.155009045241408 4.27981971726539e-12 NA NA NA hsa-miR-23a-3p GSK3B 0.334693010651106 0.00144448147063433 -0.00812669327682514 0.891858643750953 mirMAP;miRNATAP -0.109796590797861 1.08992592703854e-06 NA NA NA hsa-miR-26a-5p GSK3B 0.033823776747294 0.726610414342369 -0.00812669327682514 0.891858643750953 miRNAWalker2_validate;miRNATAP -0.124162553965791 1.9677050059957e-06 NA NA NA hsa-miR-26b-5p GSK3B -0.0984536538762768 0.231803769574623 -0.00812669327682514 0.891858643750953 miRNATAP -0.242462216035707 2.93659997949065e-16 NA NA NA hsa-miR-27a-3p GSK3B 0.303760032895792 0.00457375391189806 -0.00812669327682514 0.891858643750953 miRNATAP -0.117289047610676 2.03194827601435e-08 NA NA NA hsa-miR-28-5p GSK3B 0.104003572105781 0.153594705579534 -0.00812669327682514 0.891858643750953 miRanda;miRNATAP -0.153581288033644 5.93445649657903e-07 NA NA NA hsa-miR-29b-3p GSK3B -0.178522712044497 0.0856106432165465 -0.00812669327682514 0.891858643750953 miRTarBase;miRNATAP -0.103024519445492 4.4831296698937e-06 NA NA NA hsa-miR-30a-3p GSK3B 0.0655410309550977 0.509541256241954 -0.00812669327682514 0.891858643750953 miRNATAP -0.169749215445873 3.72672045563906e-10 NA NA NA hsa-miR-320a GSK3B 0.092135599636725 0.243028758989929 -0.00812669327682514 0.891858643750953 miRanda;mirMAP -0.157366520986088 1.86207365140069e-06 NA NA NA hsa-miR-320c GSK3B 0.343259124189966 0.000248338401291051 -0.00812669327682514 0.891858643750953 miRanda;mirMAP -0.105871202268296 3.45649295394405e-06 NA NA NA hsa-miR-362-5p GSK3B -0.0730185557229279 0.425572997292224 -0.00812669327682514 0.891858643750953 miRNATAP -0.14675268746991 1.54588705430119e-10 NA NA NA hsa-miR-374b-5p GSK3B -0.210113949579608 0.0056866083818614 -0.00812669327682514 0.891858643750953 mirMAP -0.110240926558385 0.000413708905199806 NA NA NA hsa-miR-590-3p GSK3B 0.312951515438396 0.000480455423843996 -0.00812669327682514 0.891858643750953 miRanda;miRNATAP -0.123129209082978 1.01101816997511e-07 NA NA NA hsa-miR-664a-3p GSK3B 0.0413918462467198 0.611334357897022 -0.00812669327682514 0.891858643750953 mirMAP -0.156185915215911 2.17302109400583e-09 NA NA NA hsa-miR-708-5p GSK3B -0.00936519718301376 0.919857671524527 -0.00812669327682514 0.891858643750953 miRNATAP -0.121813780965153 5.84337104157163e-07 NA NA NA hsa-miR-99a-3p GSK3B -0.122217114840767 0.0886582098510828 -0.00812669327682514 0.891858643750953 miRNATAP -0.17367661337822 1.70824739875318e-08 NA NA NA hsa-miR-139-5p JUN -0.647754756897633 2.15378307237163e-06 0.37954584650033 7.46220464317962e-05 MirTarget;PITA;miRanda;miRNATAP -0.185022658773887 2.83059205114288e-11 25499265 In this study we report the identification of a novel negative feedback loop formed between miR-139 and its oncogenic target Jun; In this loop miR-139 could inhibit Jun expression by targeting a conserved site on its 3'-UTR whereas Jun could induce miR-139 expression in a dose dependent manner through a distant upstream regulatory element; Interestingly aberration in this loop was found in human gastric cancer where miR-139 was down-regulated and inversely correlated with Jun expression; Further functional analysis showed that restored expression of miR-139 in gastric cancer cells significantly induces apoptosis and inhibits cell migration and proliferation as well as tumour growth through targeting Jun; Given that miR-139 and Jun are deregulated in many cancers our findings here might have broader implication in other types of human cancers cell migration gastric cancer hsa-miR-3065-3p LEF1 -0.261348288537884 0.0343753235107924 0.349249191099076 1.77383475142338e-06 miRNATAP -0.100710465302502 0.000109595604303436 NA NA NA hsa-let-7g-3p LRP5 0.00917503654783935 0.92786975338911 0.123563044267433 0.0468589649783651 miRNATAP -0.104754196273409 8.61431973536015e-06 NA NA NA hsa-miR-23b-3p LRP5 0.0476610245860094 0.630277683372344 0.123563044267433 0.0468589649783651 MirTarget;miRNATAP -0.237982034409682 4.50793353260598e-21 NA NA NA hsa-miR-375 LRP5 -0.0268401141324031 0.858358101444697 0.123563044267433 0.0468589649783651 miRanda;miRNATAP -0.13413046419313 1.32284192491957e-19 NA NA NA hsa-miR-106a-5p LRP6 0.110074064773897 0.13045815990621 -0.0635985031970421 0.303319357391102 mirMAP -0.125980068328227 0.00014580412557657 NA NA NA hsa-miR-15a-5p LRP6 0.142658985373611 0.0536219185009004 -0.0635985031970421 0.303319357391102 miRNATAP -0.111003845046766 0.00298186372916473 NA NA NA hsa-miR-221-3p LRP6 -0.0109507285071775 0.936440693394519 -0.0635985031970421 0.303319357391102 miRNAWalker2_validate -0.130523906664186 1.59811064011306e-15 NA NA NA hsa-miR-29a-3p LRP6 -0.224140851576083 0.0349516103550236 -0.0635985031970421 0.303319357391102 miRNATAP -0.141805934166981 3.49567757024655e-07 NA NA NA hsa-miR-29b-3p LRP6 -0.178522712044497 0.0856106432165465 -0.0635985031970421 0.303319357391102 miRNATAP -0.151746485432759 4.07659481720806e-10 NA NA NA hsa-miR-29c-3p LRP6 -0.372180390387259 0.00202634431973208 -0.0635985031970421 0.303319357391102 miRNATAP -0.110740614136909 7.80063936730743e-08 NA NA NA hsa-miR-30a-5p LRP6 -0.062942936611238 0.513851954700252 -0.0635985031970421 0.303319357391102 miRNATAP -0.229464700697363 2.97201844233808e-09 NA NA NA hsa-miR-30b-5p LRP6 -0.0858101016322106 0.263243418521854 -0.0635985031970421 0.303319357391102 miRNATAP -0.160632783947865 6.91908466338113e-06 NA NA NA hsa-miR-30c-5p LRP6 -0.0469114469943097 0.565934557464627 -0.0635985031970421 0.303319357391102 miRNATAP -0.112376443958817 0.00182554111199023 NA NA NA hsa-miR-362-5p LRP6 -0.0730185557229279 0.425572997292224 -0.0635985031970421 0.303319357391102 PITA;TargetScan;miRNATAP -0.103863338749494 3.98926398562262e-05 NA NA NA hsa-miR-671-5p LRP6 0.379677704170736 0.000129391032677459 -0.0635985031970421 0.303319357391102 PITA -0.103484233361853 5.00125005739433e-06 NA NA NA hsa-miR-7-1-3p LRP6 -0.0894475316162393 0.37322359785108 -0.0635985031970421 0.303319357391102 mirMAP -0.11219427543969 8.03295650151764e-07 NA NA NA hsa-miR-130a-3p MAPK10 0.163798739071237 0.031259491216363 -0.537388523547939 4.2393247633847e-14 miRNATAP -0.146227150931435 0.000409098979829322 NA NA NA hsa-miR-130b-3p MAPK10 0.503911467685709 9.46590588950823e-08 -0.537388523547939 4.2393247633847e-14 miRNATAP -0.240966176239797 3.00288673974579e-16 NA NA NA hsa-miR-19a-3p MAPK10 0.0466707843731911 0.576818938277755 -0.537388523547939 4.2393247633847e-14 miRNATAP -0.160174316971582 5.10852507077659e-06 NA NA NA hsa-miR-19b-3p MAPK10 -0.0138427450847924 0.856506310673067 -0.537388523547939 4.2393247633847e-14 miRNATAP -0.155216608611893 0.000219766758516242 NA NA NA hsa-miR-450b-5p MAPK10 0.270544879013992 0.00801537838499562 -0.537388523547939 4.2393247633847e-14 mirMAP -0.191975437167481 2.95244540267408e-12 NA NA NA hsa-miR-454-3p MAPK10 0.177318549827649 0.0120865170334418 -0.537388523547939 4.2393247633847e-14 miRNATAP -0.177198825931711 1.91997293458149e-05 NA NA NA hsa-miR-590-3p MAPK10 0.312951515438396 0.000480455423843996 -0.537388523547939 4.2393247633847e-14 miRanda;mirMAP -0.166335972989874 8.93923250001752e-08 NA NA NA hsa-miR-590-5p MAPK10 0.16946027035949 0.0386004382081678 -0.537388523547939 4.2393247633847e-14 PITA;miRanda;miRNATAP -0.145955971255782 2.52817190707301e-05 NA NA NA hsa-miR-10a-5p MAPK8 1.10332501906319 5.3831631561183e-08 -0.302931149567583 0.000188583880708274 miRNAWalker2_validate -0.120186654516686 3.43413005950355e-13 NA NA NA hsa-miR-16-2-3p MAPK8 0.468816222075619 7.04377763166292e-05 -0.302931149567583 0.000188583880708274 mirMAP -0.102102855430457 0.000418952571359225 NA NA NA hsa-miR-22-5p MAPK8 0.0437233965539527 0.639996108995995 -0.302931149567583 0.000188583880708274 mirMAP -0.175094083929253 2.69922381021858e-06 NA NA NA hsa-miR-30a-5p MAPK8 -0.062942936611238 0.513851954700252 -0.302931149567583 0.000188583880708274 mirMAP -0.407693291423913 2.44429012802795e-12 NA NA NA hsa-miR-30b-5p MAPK8 -0.0858101016322106 0.263243418521854 -0.302931149567583 0.000188583880708274 mirMAP -0.161604562972212 0.00297088085323934 NA NA NA hsa-miR-30c-5p MAPK8 -0.0469114469943097 0.565934557464627 -0.302931149567583 0.000188583880708274 mirMAP -0.352021480256678 5.75202015716757e-11 NA NA NA hsa-miR-374a-3p MAPK8 0.176226170437625 0.0343958848425446 -0.302931149567583 0.000188583880708274 mirMAP -0.233850674687013 5.69445641069691e-06 NA NA NA hsa-miR-590-3p MAPK8 0.312951515438396 0.000480455423843996 -0.302931149567583 0.000188583880708274 miRNATAP -0.178854419631098 3.01021919217562e-06 NA NA NA hsa-let-7i-5p MAPK9 0.0952853587923244 0.192120688957249 -0.250992535130042 2.41271995485752e-05 miRNATAP -0.111926815056819 0.00309462880153316 NA NA NA hsa-miR-106b-5p MAPK9 0.167096183547615 0.0497544396383451 -0.250992535130042 2.41271995485752e-05 miRNAWalker2_validate;miRNATAP -0.10590505262462 0.000236784602878243 NA NA NA hsa-miR-320a MAPK9 0.092135599636725 0.243028758989929 -0.250992535130042 2.41271995485752e-05 miRanda;miRNATAP -0.209587243417478 6.52556108505869e-10 NA NA NA hsa-miR-320b MAPK9 0.283477746304177 0.0005953763020907 -0.250992535130042 2.41271995485752e-05 miRanda;miRNATAP -0.150322035936768 6.40324029911169e-09 NA NA NA hsa-miR-320c MAPK9 0.343259124189966 0.000248338401291051 -0.250992535130042 2.41271995485752e-05 miRanda;miRNATAP -0.160739998379643 5.6021711014594e-12 NA NA NA hsa-miR-542-3p MAPK9 0.0835995677900829 0.403838744494071 -0.250992535130042 2.41271995485752e-05 miRanda -0.120047809070845 4.59691685311462e-07 NA NA NA hsa-miR-93-5p MAPK9 0.139766237971122 0.101057320076629 -0.250992535130042 2.41271995485752e-05 miRNAWalker2_validate;miRNATAP -0.21497342781919 3.19876665049407e-08 NA NA NA hsa-miR-126-3p MMP7 0.283844173647452 0.0045313860754322 0.697543155810088 0.00324788941211708 miRNAWalker2_validate -0.3502501519074 0.0033763039665017 NA NA NA hsa-miR-129-5p MMP7 -0.567133990117126 0.00116152215679936 0.697543155810088 0.00324788941211708 miRanda -0.25155384306286 3.16357442904307e-05 NA NA NA hsa-miR-137 MMP7 -0.924849266740909 1.546832202049e-06 0.697543155810088 0.00324788941211708 miRanda -0.347040422614271 3.38225239435272e-11 NA NA NA hsa-miR-346 MMP7 -0.577786425963268 2.10883270131593e-09 0.697543155810088 0.00324788941211708 miRanda -0.499274110585366 2.56008929117828e-06 NA NA NA hsa-miR-496 MMP7 -0.139833482232877 0.39597541862532 0.697543155810088 0.00324788941211708 miRanda -0.257071483382742 5.38213850385967e-05 NA NA NA hsa-let-7c-5p MYC -0.04295851886768 0.676052842748691 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.187493318710893 0.00114816000552179 22128178 MicroRNA let 7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells prostate cancer hsa-let-7f-5p MYC 0.0508269185845673 0.62677515045793 0.0342990533418108 0.742963156666191 miRNAWalker2_validate -0.234906036376788 1.38501616912732e-05 NA NA NA hsa-let-7g-5p MYC -0.0253396334608382 0.742556489443668 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.402035322238661 2.54889860814805e-08 NA NA NA hsa-miR-145-5p MYC 0.108948399943015 0.310032352776693 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.26620175812587 1.77011092539307e-10 23919393;21836381;23499891;24356567;21092188;21690566;21723890;27482839 MicroRNA 145 function as a cell growth repressor by directly targeting c Myc in human ovarian cancer; We show that miR-145 directly target the c-Myc 3'-UTR; Moreover ectopic expression of c-Myc reduces the inhibition of cell proliferation caused by miR-145 transfection; Cell cycle assay showed that up-regulation of miR-145 reduces S phase population and restoration of c-Myc can rescue this reduction; These findings indicate that miR-145 inhibits cell proliferation and promotes cell apoptosis by targeting c-Myc 3'-UTR;The ectopic expression of miR-145 showed a significant growth inhibition in both canine and human melanoma cells tested and the effect was achieved partly by suppressing c-MYC in canine melanoma LMeC and in human melanoma A2058 and Mewo cells;The ectopic expression of miR-145 inhibited the growth of DLD-1 cells by disturbing β-catenin translocation into the nucleus thereby leading to the down-regulation of LEF/TCF transcriptional target genes c-Myc and CyclinD1;miR 145 inhibits proliferation and invasion of esophageal squamous cell carcinoma in part by targeting c Myc; The impact of overexpression of miR-145 on putative target c-Myc was subsequently confirmed via Western blot; Overexpression of miR-145 significantly decreased p < 0.05 the protein level of c-Myc which has previously been identified as a direct target of miR-145; Our results demonstrate that overexpression of miR-145 inhibits tumor growth in part by targeting c-Myc;In colon cancer cells c-Myc is a confirmed direct target for miR-145; The aim of this work was to investigate the effect of miR-145 and c-Myc on proliferation of NSCLC cells using the NSCLC cell lines A549 and H23 as models; We further showed that c-Myc was a direct target for miR-145; Taken together our study results demonstrate that miR-145 inhibits proliferation of NSCLC cells through c-Myc;miR-145 delivery reduced tumor proliferation and increased apoptosis with concomitant repression of c-Myc and ERK5 as novel regulatory target of miR-145;We found a reverse-correlation between the expression of miR-145 and its target genes such as fascin-1 c-myc SMAD2/3 and IGF-1R in breast cancer cell lines and breast cancer patient tissues;Consequently the increased miR-145 induced G1 cell cycle arrest reduced tumor proliferation and increased apoptosis inhibited HCT-116 cell migration and suppressed c-MYC expressions a regulatory target of miR-145 ;;;;;;;cell migration ovarian cancer;melanoma;colon cancer;esophageal cancer;lung squamous cell cancer;colon cancer;breast cancer;colon cancer hsa-miR-24-3p MYC 0.133257261462871 0.212960921400853 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.297311537056991 1.14667789168757e-11 NA NA NA hsa-miR-26a-5p MYC 0.033823776747294 0.726610414342369 0.0342990533418108 0.742963156666191 miRNAWalker2_validate -0.349840372726607 4.11115213986892e-11 21901171 Our results identify new molecular targets of c-Myc in AML and highlight miR-26a attractiveness as a therapeutic target in leukemia acute myeloid leukemia hsa-miR-335-5p MYC 0.0938511632756978 0.336889056387694 0.0342990533418108 0.742963156666191 miRNAWalker2_validate -0.221233805698315 6.63171764745164e-07 NA NA NA hsa-miR-34a-5p MYC 0.143472919835524 0.211283228567057 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.469833736893329 6.08752675410229e-40 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-34c-5p MYC 0.181931113688093 0.257266965617363 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase;miRanda -0.212118906251778 1.73484497587865e-16 NA NA NA hsa-miR-377-5p MYC -0.254102489855821 0.081507589808783 0.0342990533418108 0.742963156666191 miRNATAP -0.197215758202484 1.41992056070433e-11 NA NA NA hsa-miR-378a-3p MYC 0.251965146196782 0.0137483824840962 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.135286330402019 0.00204077080845563 NA NA NA hsa-miR-590-3p MYC 0.312951515438396 0.000480455423843996 0.0342990533418108 0.742963156666191 miRanda -0.223628987104378 2.58191493375387e-06 24200043 We identified important regulators MYC NFKB1 miR-590 and miR-570 and significant miRNA-TF synergistic regulatory motifs by random simulations lung squamous cell cancer hsa-miR-744-5p MYC -0.31868579180387 0.000969037378618306 0.0342990533418108 0.742963156666191 miRNAWalker2_validate -0.208939879123018 7.28554627025748e-06 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-miR-98-5p MYC -0.0806971683871618 0.251777941211683 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.482234879670646 1.25183084383233e-12 NA NA NA hsa-miR-137 NFATC1 -0.924849266740909 1.546832202049e-06 0.204786711368586 0.0511949488637229 miRanda;miRNATAP -0.107798622041435 3.4819034015331e-06 NA NA NA hsa-miR-139-5p NFATC1 -0.647754756897633 2.15378307237163e-06 0.204786711368586 0.0511949488637229 miRanda -0.256587875136984 2.02892529769674e-14 NA NA NA hsa-miR-133a-3p NFATC2 -0.335058908302964 0.0180402783121034 0.373288538309896 0.0141934989113001 MirTarget -0.126883299764603 0.00682609791314944 NA NA NA hsa-miR-137 NFATC2 -0.924849266740909 1.546832202049e-06 0.373288538309896 0.0141934989113001 MirTarget -0.159446756645839 2.79388179466433e-06 NA NA NA hsa-miR-19a-3p NFATC2 0.0466707843731911 0.576818938277755 0.373288538309896 0.0141934989113001 mirMAP -0.236809111690551 0.00474447094856751 NA NA NA hsa-miR-19b-3p NFATC2 -0.0138427450847924 0.856506310673067 0.373288538309896 0.0141934989113001 mirMAP -0.335169271204236 0.000783248779037379 NA NA NA hsa-miR-767-3p NFATC2 -0.429854368420513 0.000821445291167688 0.373288538309896 0.0141934989113001 mirMAP -0.151337879902996 0.0044563221543633 NA NA NA hsa-miR-9-5p NFATC2 -0.125377971246422 0.269896477802284 0.373288538309896 0.0141934989113001 MirTarget -1.15506700903417 6.16080043646465e-16 NA NA NA hsa-miR-9-5p NFATC3 -0.125377971246422 0.269896477802284 0.243130574740432 4.77137503381453e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.264692712043712 4.40776113604208e-13 NA NA NA hsa-miR-105-5p NFATC4 -0.567459149851677 8.20858944634795e-06 -0.081124592384517 0.381792074940761 mirMAP -0.233035161096435 4.65846890944727e-14 NA NA NA hsa-miR-181a-2-3p NFATC4 -0.0630409614874416 0.473088318215936 -0.081124592384517 0.381792074940761 mirMAP -0.280233830341353 9.31458848849117e-06 NA NA NA hsa-miR-3607-3p NFATC4 -0.0118040987013632 0.907228689257085 -0.081124592384517 0.381792074940761 miRNATAP -0.166177847132163 2.36930087506819e-05 NA NA NA hsa-miR-125a-5p NKD1 -0.0833349424517387 0.325440200253607 -0.0915570732498647 0.331718005040373 miRanda -0.451115517659672 1.5368924178677e-15 NA NA NA hsa-miR-200b-3p NKD1 0.245768526504511 0.0580744465744737 -0.0915570732498647 0.331718005040373 TargetScan -0.303490431896851 4.1741432749643e-24 NA NA NA hsa-miR-21-5p NKD1 1.0504925175311 2.58081295984106e-11 -0.0915570732498647 0.331718005040373 mirMAP -0.21908671085636 2.66527031428981e-15 NA NA NA hsa-miR-24-3p NKD1 0.133257261462871 0.212960921400853 -0.0915570732498647 0.331718005040373 miRNAWalker2_validate -0.275124372813364 1.3307969599146e-11 NA NA NA hsa-miR-330-5p NKD1 -0.262932095995605 0.0465226565966658 -0.0915570732498647 0.331718005040373 miRanda;miRNATAP -0.12931550105749 1.67983789674822e-05 NA NA NA hsa-miR-361-5p NKD1 0.0107519600643302 0.882230614095565 -0.0915570732498647 0.331718005040373 miRanda -0.416263214368694 6.31521704396371e-10 NA NA NA hsa-miR-365a-3p NKD1 -0.184222766207919 0.0292663235724171 -0.0915570732498647 0.331718005040373 miRNATAP -0.304461600393138 1.69505981702138e-10 NA NA NA hsa-miR-369-3p NKD1 -0.153496605399658 0.296055925448078 -0.0915570732498647 0.331718005040373 PITA;miRNATAP -0.174524831197603 7.06239985105493e-11 NA NA NA hsa-miR-376a-5p NKD1 -0.0877544252790136 0.551096721204598 -0.0915570732498647 0.331718005040373 mirMAP -0.176244244905665 8.83679007206109e-11 NA NA NA hsa-miR-421 NKD1 -0.171573235029879 0.0518112933651029 -0.0915570732498647 0.331718005040373 mirMAP -0.119894770232346 0.00829384681953355 NA NA NA hsa-miR-455-3p NKD1 0.512701816402104 0.000459755983280155 -0.0915570732498647 0.331718005040373 miRNATAP -0.215845455433435 6.15042990308966e-16 NA NA NA hsa-miR-455-5p NKD1 0.332224239762 0.0106491358056238 -0.0915570732498647 0.331718005040373 miRanda -0.288932246848287 8.76662920338515e-23 NA NA NA hsa-miR-491-3p NKD1 -0.523374665885358 1.93479565404951e-05 -0.0915570732498647 0.331718005040373 PITA -0.13574336905197 2.48584952872278e-05 NA NA NA hsa-miR-496 NKD1 -0.139833482232877 0.39597541862532 -0.0915570732498647 0.331718005040373 miRanda -0.138557661871477 1.07088700008146e-08 NA NA NA hsa-miR-501-5p NKD1 0.0878951859817452 0.309663377222443 -0.0915570732498647 0.331718005040373 mirMAP -0.265554793517043 6.54886795198399e-09 NA NA NA hsa-miR-532-5p NKD1 0.0263466708637097 0.75763006039876 -0.0915570732498647 0.331718005040373 PITA;miRNATAP -0.252633919322512 8.51535017530622e-06 NA NA NA hsa-miR-195-3p NLK 0.100105455903079 0.133362389112338 -0.134361431213828 0.0181559794912115 mirMAP -0.146201038430761 1.34424900039389e-05 NA NA NA hsa-miR-320c NLK 0.343259124189966 0.000248338401291051 -0.134361431213828 0.0181559794912115 miRanda -0.113293155197013 1.87419575521197e-06 NA NA NA hsa-miR-106b-5p PLCB1 0.167096183547615 0.0497544396383451 -0.754503694742342 7.80713033371919e-15 miRNATAP -0.355619226188626 2.40002082811068e-11 NA NA NA hsa-miR-130a-3p PLCB1 0.163798739071237 0.031259491216363 -0.754503694742342 7.80713033371919e-15 miRNATAP -0.201987912883643 0.000724236719747379 NA NA NA hsa-miR-130b-3p PLCB1 0.503911467685709 9.46590588950823e-08 -0.754503694742342 7.80713033371919e-15 miRNATAP -0.280680344610094 7.00485340099889e-11 NA NA NA hsa-miR-142-3p PLCB1 0.558908907203977 1.37828834702416e-05 -0.754503694742342 7.80713033371919e-15 PITA;miRanda;miRNATAP -0.198344624318732 6.10123568774459e-10 NA NA NA hsa-miR-16-2-3p PLCB1 0.468816222075619 7.04377763166292e-05 -0.754503694742342 7.80713033371919e-15 mirMAP -0.254360940421697 2.25584813763924e-14 NA NA NA hsa-miR-195-3p PLCB1 0.100105455903079 0.133362389112338 -0.754503694742342 7.80713033371919e-15 mirMAP -0.163651839185901 0.00930416476700517 NA NA NA hsa-miR-199a-3p PLCB1 0.41226331871076 0.000497136154474528 -0.754503694742342 7.80713033371919e-15 PITA -0.185447179677909 7.28705075319753e-08 NA NA NA hsa-miR-199b-3p PLCB1 0.411848361704393 0.000517815011892379 -0.754503694742342 7.80713033371919e-15 PITA;miRNATAP -0.18464021088506 7.77115785139915e-08 NA NA NA hsa-miR-19a-3p PLCB1 0.0466707843731911 0.576818938277755 -0.754503694742342 7.80713033371919e-15 miRNATAP -0.146711749045979 0.00402119285553347 NA NA NA hsa-miR-19b-3p PLCB1 -0.0138427450847924 0.856506310673067 -0.754503694742342 7.80713033371919e-15 miRNATAP -0.165435851838661 0.00652254325256773 NA NA NA hsa-miR-26a-2-3p PLCB1 0.26597501648608 0.000796444054340143 -0.754503694742342 7.80713033371919e-15 mirMAP -0.327871555984431 8.34907198082641e-11 NA NA NA hsa-miR-26a-5p PLCB1 0.033823776747294 0.726610414342369 -0.754503694742342 7.80713033371919e-15 miRNATAP -0.214574434093412 2.40919628662661e-05 NA NA NA hsa-miR-26b-5p PLCB1 -0.0984536538762768 0.231803769574623 -0.754503694742342 7.80713033371919e-15 miRNATAP -0.160154844449247 0.00685742327404446 NA NA NA hsa-miR-320a PLCB1 0.092135599636725 0.243028758989929 -0.754503694742342 7.80713033371919e-15 miRanda -0.315530375044611 8.39247685795945e-07 NA NA NA hsa-miR-320b PLCB1 0.283477746304177 0.0005953763020907 -0.754503694742342 7.80713033371919e-15 miRanda -0.303568401342425 3.65787286735261e-10 NA NA NA hsa-miR-320c PLCB1 0.343259124189966 0.000248338401291051 -0.754503694742342 7.80713033371919e-15 miRanda -0.262967630509731 2.28153065995034e-09 NA NA NA hsa-miR-335-3p PLCB1 0.34540584335595 0.00043848660222294 -0.754503694742342 7.80713033371919e-15 mirMAP -0.263243206465081 4.68142339865433e-10 NA NA NA hsa-miR-34a-5p PLCB1 0.143472919835524 0.211283228567057 -0.754503694742342 7.80713033371919e-15 miRNATAP -0.237090403998632 3.22466889297104e-11 NA NA NA hsa-miR-34c-5p PLCB1 0.181931113688093 0.257266965617363 -0.754503694742342 7.80713033371919e-15 miRanda;miRNATAP -0.161067199419796 6.63347287121138e-11 NA NA NA hsa-miR-361-5p PLCB1 0.0107519600643302 0.882230614095565 -0.754503694742342 7.80713033371919e-15 PITA;miRanda -0.204401203769615 0.00334503305896512 NA NA NA hsa-miR-423-5p PLCB1 0.0965587900813789 0.148039180704338 -0.754503694742342 7.80713033371919e-15 miRNAWalker2_validate;PITA;miRNATAP -0.385448533149312 1.41648029257115e-08 NA NA NA hsa-miR-452-5p PLCB1 0.599327068454211 1.02031931068531e-05 -0.754503694742342 7.80713033371919e-15 mirMAP -0.227290137432953 3.74896844715825e-15 NA NA NA hsa-miR-548b-3p PLCB1 0.340474544210108 0.00224491592019745 -0.754503694742342 7.80713033371919e-15 PITA -0.287411734587567 1.35204120334276e-15 NA NA NA hsa-miR-590-3p PLCB1 0.312951515438396 0.000480455423843996 -0.754503694742342 7.80713033371919e-15 PITA;miRanda;mirMAP -0.335986363085496 3.32410773030187e-14 NA NA NA hsa-miR-590-5p PLCB1 0.16946027035949 0.0386004382081678 -0.754503694742342 7.80713033371919e-15 PITA;miRanda -0.291223950235122 4.39230424162124e-09 NA NA NA hsa-miR-93-5p PLCB1 0.139766237971122 0.101057320076629 -0.754503694742342 7.80713033371919e-15 miRNATAP -0.575303170431998 1.08275280407868e-15 NA NA NA hsa-miR-125a-5p PLCB3 -0.0833349424517387 0.325440200253607 0.104299977491075 0.0654928638566662 miRanda -0.268290047376249 2.36229399621088e-19 NA NA NA hsa-miR-197-3p PLCB3 -0.176796295244328 0.0837698554789217 0.104299977491075 0.0654928638566662 miRNAWalker2_validate -0.13108266766771 1.99588200154712e-08 NA NA NA hsa-miR-23a-3p PLCB4 0.334693010651106 0.00144448147063433 -0.320804796488082 6.54225627063888e-05 miRNATAP -0.185426712803235 5.50306083305118e-07 NA NA NA hsa-miR-30a-5p PLCB4 -0.062942936611238 0.513851954700252 -0.320804796488082 6.54225627063888e-05 miRNATAP -0.297949809526295 3.70603372945578e-07 NA NA NA hsa-miR-450b-5p PLCB4 0.270544879013992 0.00801537838499562 -0.320804796488082 6.54225627063888e-05 PITA;mirMAP -0.163209762534827 1.62663164780636e-06 NA NA NA hsa-miR-455-5p PLCB4 0.332224239762 0.0106491358056238 -0.320804796488082 6.54225627063888e-05 PITA;miRanda -0.107015735958755 4.98916092048072e-05 NA NA NA hsa-miR-708-3p PLCB4 0.00458267260363954 0.962455132950708 -0.320804796488082 6.54225627063888e-05 miRNATAP -0.135953888463738 0.000575517640535993 NA NA NA hsa-miR-107 PPP2R5A -0.121070851008387 0.198381281894242 -0.560968743573282 1.28924141102638e-12 miRanda -0.137312868546319 0.000101059157362503 NA NA NA hsa-miR-299-5p PPP2R5A -0.0814737109317336 0.57620244226785 -0.560968743573282 1.28924141102638e-12 PITA;miRNATAP -0.102718337044819 2.18651702505648e-06 NA NA NA hsa-miR-335-5p PPP2R5A 0.0938511632756978 0.336889056387694 -0.560968743573282 1.28924141102638e-12 miRNAWalker2_validate -0.173366581478925 9.81646000324009e-08 NA NA NA hsa-miR-34a-5p PPP2R5A 0.143472919835524 0.211283228567057 -0.560968743573282 1.28924141102638e-12 MirTarget;miRNATAP -0.183627035968764 2.98949511678076e-11 NA NA NA hsa-miR-34c-5p PPP2R5A 0.181931113688093 0.257266965617363 -0.560968743573282 1.28924141102638e-12 MirTarget;PITA;miRanda;miRNATAP -0.122979122974169 1.16976245363982e-10 NA NA NA hsa-miR-582-5p PPP2R5A -0.215764335500665 0.0760892640434509 -0.560968743573282 1.28924141102638e-12 PITA;miRNATAP -0.110269895061871 1.57160284780262e-05 NA NA NA hsa-miR-590-3p PPP2R5A 0.312951515438396 0.000480455423843996 -0.560968743573282 1.28924141102638e-12 miRNAWalker2_validate -0.109469467724205 0.00178010792298095 NA NA NA hsa-miR-146b-5p PPP2R5C 0.441078059667297 0.000237619929889385 -0.254272948072342 1.69001734328025e-06 miRanda -0.104636941944054 6.44013765390368e-15 NA NA NA hsa-miR-15a-5p PPP2R5C 0.142658985373611 0.0536219185009004 -0.254272948072342 1.69001734328025e-06 miRNATAP -0.200156920569006 1.85098904717096e-15 NA NA NA hsa-miR-15b-5p PPP2R5C 0.592863156692837 1.41971517354055e-10 -0.254272948072342 1.69001734328025e-06 miRNATAP -0.205121300896824 2.364669413921e-34 NA NA NA hsa-miR-16-5p PPP2R5C 0.246024668671282 0.00346042804503716 -0.254272948072342 1.69001734328025e-06 miRNAWalker2_validate;miRNATAP -0.16388416042408 3.74945792569191e-14 NA NA NA hsa-miR-28-3p PPP2R5C 0.139444423971018 0.0811187936164314 -0.254272948072342 1.69001734328025e-06 PITA -0.115674445248112 5.47154420556708e-06 NA NA NA hsa-let-7a-3p PPP2R5E 0.0530563276543763 0.370749834463566 -0.00642086237028749 0.899053449389186 mirMAP -0.113525985389828 0.00166602460317483 NA NA NA hsa-miR-30a-5p PPP2R5E -0.062942936611238 0.513851954700252 -0.00642086237028749 0.899053449389186 mirMAP -0.194674812505274 1.76897834837535e-09 NA NA NA hsa-miR-30b-5p PPP2R5E -0.0858101016322106 0.263243418521854 -0.00642086237028749 0.899053449389186 mirMAP -0.182048118174176 8.27885941296834e-10 NA NA NA hsa-miR-30c-5p PPP2R5E -0.0469114469943097 0.565934557464627 -0.00642086237028749 0.899053449389186 mirMAP -0.213723164961204 4.89620491763908e-13 NA NA NA hsa-miR-361-5p PPP2R5E 0.0107519600643302 0.882230614095565 -0.00642086237028749 0.899053449389186 miRanda -0.101133170947133 0.00199076639213648 NA NA NA hsa-miR-365a-3p PPP2R5E -0.184222766207919 0.0292663235724171 -0.00642086237028749 0.899053449389186 miRNAWalker2_validate -0.10652573303036 3.84386723765993e-06 NA NA NA hsa-miR-374a-3p PPP2R5E 0.176226170437625 0.0343958848425446 -0.00642086237028749 0.899053449389186 MirTarget -0.120569813550011 2.35701836214203e-05 NA NA NA hsa-miR-500a-3p PPP2R5E 0.0479457078972052 0.49420307623914 -0.00642086237028749 0.899053449389186 MirTarget -0.1575021564293 7.55930237003387e-07 NA NA NA hsa-miR-502-3p PPP2R5E 0.0276791089364088 0.697605011368848 -0.00642086237028749 0.899053449389186 MirTarget;PITA;miRNATAP -0.102033264015188 0.000178779831614998 NA NA NA hsa-miR-9-3p PPP2R5E -0.184945845984695 0.0290051908009009 -0.00642086237028749 0.899053449389186 mirMAP -0.103118267073452 0.000768700677345424 NA NA NA hsa-miR-106b-5p PPP3CA 0.167096183547615 0.0497544396383451 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.156975600850481 8.08375589469546e-06 NA NA NA hsa-miR-17-5p PPP3CA 0.0975751369167082 0.20621110214601 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.156864057675735 0.000234156174021412 NA NA NA hsa-miR-20a-5p PPP3CA -0.0115865752288853 0.887069448776018 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.11299242225162 0.0039148602825986 NA NA NA hsa-miR-21-5p PPP3CA 1.0504925175311 2.58081295984106e-11 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.130424810796755 2.20070954535807e-12 NA NA NA hsa-miR-320a PPP3CA 0.092135599636725 0.243028758989929 -0.373235846566351 7.56900657293056e-08 miRanda -0.211827782030443 4.01920568101511e-07 NA NA NA hsa-miR-320b PPP3CA 0.283477746304177 0.0005953763020907 -0.373235846566351 7.56900657293056e-08 miRanda -0.144192030306541 6.21193412642773e-06 NA NA NA hsa-miR-320c PPP3CA 0.343259124189966 0.000248338401291051 -0.373235846566351 7.56900657293056e-08 miRanda -0.159502579873982 3.05354814536541e-08 NA NA NA hsa-miR-450b-5p PPP3CA 0.270544879013992 0.00801537838499562 -0.373235846566351 7.56900657293056e-08 PITA;mirMAP;miRNATAP -0.158857807775905 1.0971728867913e-09 NA NA NA hsa-miR-93-3p PPP3CA 0.0778767956494004 0.272224943247293 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.103322549875116 0.00846397616128606 NA NA NA hsa-miR-93-5p PPP3CA 0.139766237971122 0.101057320076629 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.294073353489622 5.63338473261847e-10 NA NA NA hsa-miR-15a-5p PPP3CB 0.142658985373611 0.0536219185009004 -0.433160664971454 7.64786199353402e-10 miRNATAP -0.154879727290926 0.000565344774724231 NA NA NA hsa-miR-15b-5p PPP3CB 0.592863156692837 1.41971517354055e-10 -0.433160664971454 7.64786199353402e-10 miRNATAP -0.237305735014458 6.56456884638479e-15 NA NA NA hsa-miR-30a-5p PPP3CB -0.062942936611238 0.513851954700252 -0.433160664971454 7.64786199353402e-10 miRNATAP -0.216347543291675 3.88335269674995e-06 NA NA NA hsa-miR-320a PPP3CB 0.092135599636725 0.243028758989929 -0.433160664971454 7.64786199353402e-10 miRanda -0.283610796821456 3.73775473194107e-11 NA NA NA hsa-miR-320b PPP3CB 0.283477746304177 0.0005953763020907 -0.433160664971454 7.64786199353402e-10 miRanda -0.214071216687752 5.61901615376464e-11 NA NA NA hsa-miR-320c PPP3CB 0.343259124189966 0.000248338401291051 -0.433160664971454 7.64786199353402e-10 miRanda -0.241503669878515 1.61057546698162e-16 NA NA NA hsa-miR-339-5p PPP3CB 0.273253751377152 0.0185300170790638 -0.433160664971454 7.64786199353402e-10 miRanda -0.14695495240965 2.98975197156432e-10 NA NA NA hsa-miR-424-5p PPP3CB 0.25140374049676 0.00709934939774983 -0.433160664971454 7.64786199353402e-10 miRNATAP -0.174803267163998 9.35958492728842e-09 NA NA NA hsa-miR-450b-5p PPP3CB 0.270544879013992 0.00801537838499562 -0.433160664971454 7.64786199353402e-10 MirTarget;PITA;miRNATAP -0.145409462742278 7.85383237188849e-08 NA NA NA hsa-miR-452-5p PPP3CB 0.599327068454211 1.02031931068531e-05 -0.433160664971454 7.64786199353402e-10 MirTarget;miRNATAP -0.100917826632377 3.76376326737129e-07 NA NA NA hsa-miR-501-5p PPP3CB 0.0878951859817452 0.309663377222443 -0.433160664971454 7.64786199353402e-10 PITA;miRNATAP -0.110974250509852 0.000497821238894801 NA NA NA hsa-miR-590-3p PPP3CB 0.312951515438396 0.000480455423843996 -0.433160664971454 7.64786199353402e-10 miRanda -0.13889306492083 5.08331239857392e-06 NA NA NA hsa-miR-500a-3p PPP3CC 0.0479457078972052 0.49420307623914 -0.0407919825674279 0.323390220477665 MirTarget;miRNATAP -0.107532400267747 7.33877743778064e-06 NA NA NA hsa-miR-27a-3p PPP3R1 0.303760032895792 0.00457375391189806 -0.284481378057962 3.41822765696265e-05 miRNATAP -0.102375961650782 9.77727749562009e-05 NA NA NA hsa-miR-320a PPP3R1 0.092135599636725 0.243028758989929 -0.284481378057962 3.41822765696265e-05 PITA;miRanda -0.228132769092911 2.62987783565586e-08 NA NA NA hsa-miR-320b PPP3R1 0.283477746304177 0.0005953763020907 -0.284481378057962 3.41822765696265e-05 PITA;miRanda -0.139121452927635 9.32245529079262e-06 NA NA NA hsa-miR-320c PPP3R1 0.343259124189966 0.000248338401291051 -0.284481378057962 3.41822765696265e-05 PITA;miRanda -0.155051607654631 4.4227147992575e-08 NA NA NA hsa-miR-93-5p PPP3R1 0.139766237971122 0.101057320076629 -0.284481378057962 3.41822765696265e-05 MirTarget;miRNATAP -0.159907992777141 0.000711555619167879 NA NA NA hsa-miR-141-3p PRICKLE1 0.41120561991992 0.000393344390969055 -0.148143892558501 0.125292853289822 TargetScan -0.105602907175083 0.00294584254377793 NA NA NA hsa-miR-3065-5p PRICKLE1 -0.262608140481507 0.0414570974148034 -0.148143892558501 0.125292853289822 mirMAP -0.119250283702284 0.000152161568156932 NA NA NA hsa-miR-30a-5p PRICKLE1 -0.062942936611238 0.513851954700252 -0.148143892558501 0.125292853289822 miRNATAP -0.408799224673342 2.64163826090125e-09 NA NA NA hsa-miR-30c-5p PRICKLE1 -0.0469114469943097 0.565934557464627 -0.148143892558501 0.125292853289822 miRNATAP -0.279579017606741 1.15093653150994e-05 NA NA NA hsa-let-7a-3p PRICKLE2 0.0530563276543763 0.370749834463566 -0.423685061162764 1.07449975613235e-11 mirMAP -0.253035655753344 1.37866756418783e-08 NA NA NA hsa-miR-130b-5p PRICKLE2 0.413070888963592 1.98866876365509e-06 -0.423685061162764 1.07449975613235e-11 mirMAP -0.196830927417994 1.23758718152679e-12 NA NA NA hsa-miR-18a-5p PRICKLE2 0.175320895022849 0.0732549187136286 -0.423685061162764 1.07449975613235e-11 MirTarget -0.130828078444816 5.28404619668125e-08 NA NA NA hsa-miR-19a-3p PRICKLE2 0.0466707843731911 0.576818938277755 -0.423685061162764 1.07449975613235e-11 MirTarget;miRNATAP -0.201458575078818 6.73132204617389e-12 NA NA NA hsa-miR-19b-3p PRICKLE2 -0.0138427450847924 0.856506310673067 -0.423685061162764 1.07449975613235e-11 MirTarget;miRNATAP -0.252840323406936 4.3140725028971e-13 NA NA NA hsa-miR-26a-2-3p PRICKLE2 0.26597501648608 0.000796444054340143 -0.423685061162764 1.07449975613235e-11 mirMAP -0.12752089896451 2.04267293020011e-05 NA NA NA hsa-miR-320a PRICKLE2 0.092135599636725 0.243028758989929 -0.423685061162764 1.07449975613235e-11 mirMAP -0.209890706667529 2.03452232187e-08 NA NA NA hsa-miR-320b PRICKLE2 0.283477746304177 0.0005953763020907 -0.423685061162764 1.07449975613235e-11 mirMAP -0.154007986440008 6.71005388212479e-08 NA NA NA hsa-miR-320c PRICKLE2 0.343259124189966 0.000248338401291051 -0.423685061162764 1.07449975613235e-11 mirMAP -0.136065777565419 1.47925424994856e-07 NA NA NA hsa-miR-374a-3p PRICKLE2 0.176226170437625 0.0343958848425446 -0.423685061162764 1.07449975613235e-11 MirTarget;miRNATAP -0.173379378441762 1.02640946911306e-06 NA NA NA hsa-miR-500a-5p PRICKLE2 0.0634452729978863 0.396072382601677 -0.423685061162764 1.07449975613235e-11 mirMAP -0.151249035671304 2.08254978586848e-06 NA NA NA hsa-miR-576-5p PRICKLE2 0.106482276040047 0.194379152564166 -0.423685061162764 1.07449975613235e-11 mirMAP -0.146463390843431 5.48345983727012e-07 NA NA NA hsa-miR-590-3p PRICKLE2 0.312951515438396 0.000480455423843996 -0.423685061162764 1.07449975613235e-11 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.155254748165202 3.29620132146779e-09 NA NA NA hsa-miR-590-5p PRICKLE2 0.16946027035949 0.0386004382081678 -0.423685061162764 1.07449975613235e-11 MirTarget;PITA;miRanda -0.124763632712319 2.08078838014272e-05 NA NA NA hsa-miR-195-3p PRKACB 0.100105455903079 0.133362389112338 -0.220744787859509 0.000769904555544923 mirMAP -0.108467815706043 0.00216235374196591 NA NA NA hsa-miR-19b-3p PRKACB -0.0138427450847924 0.856506310673067 -0.220744787859509 0.000769904555544923 miRNAWalker2_validate;MirTarget;miRNATAP -0.139345436156152 4.31724651745926e-05 NA NA NA hsa-miR-93-5p PRKACB 0.139766237971122 0.101057320076629 -0.220744787859509 0.000769904555544923 miRNAWalker2_validate -0.173086797632099 2.75308372550666e-05 NA NA NA hsa-miR-146b-5p PRKCA 0.441078059667297 0.000237619929889385 -0.289954367502515 3.07027667899011e-05 mirMAP -0.14319708794989 9.06517098676715e-13 NA NA NA hsa-miR-186-5p PRKCA 0.0606381894130505 0.514217717592464 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.150359410939945 4.84077626913968e-08 NA NA NA hsa-miR-1976 PRKCA 0.127074435034705 0.277235601775457 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.108813705938178 3.46283535790712e-08 NA NA NA hsa-miR-200c-3p PRKCA 0.413752622631695 8.6936333715621e-06 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.178242109766722 4.41123343449352e-13 NA NA NA hsa-miR-22-5p PRKCA 0.0437233965539527 0.639996108995995 -0.289954367502515 3.07027667899011e-05 mirMAP -0.109722618118012 1.49794234596401e-05 NA NA NA hsa-miR-24-2-5p PRKCA 0.285455874963858 0.00610163594056254 -0.289954367502515 3.07027667899011e-05 miRNAWalker2_validate -0.126181943667759 1.61489847928406e-08 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-27b-5p PRKCA 0.224282840351546 0.00630787296051719 -0.289954367502515 3.07027667899011e-05 mirMAP -0.177695243384062 3.0717917979023e-10 NA NA NA hsa-miR-339-5p PRKCA 0.273253751377152 0.0185300170790638 -0.289954367502515 3.07027667899011e-05 mirMAP -0.144247762214447 3.06350803308541e-13 NA NA NA hsa-miR-374a-3p PRKCA 0.176226170437625 0.0343958848425446 -0.289954367502515 3.07027667899011e-05 mirMAP -0.183155883331884 1.46022453353189e-07 NA NA NA hsa-miR-452-5p PRKCA 0.599327068454211 1.02031931068531e-05 -0.289954367502515 3.07027667899011e-05 mirMAP -0.107144316873697 1.95734554580544e-10 NA NA NA hsa-miR-500a-5p PRKCA 0.0634452729978863 0.396072382601677 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.184254955997398 3.38268451218896e-09 NA NA NA hsa-miR-501-5p PRKCA 0.0878951859817452 0.309663377222443 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.110873198819 4.40374990873549e-05 NA NA NA hsa-miR-505-3p PRKCA 0.115486008167472 0.109833720698312 -0.289954367502515 3.07027667899011e-05 miRNAWalker2_validate -0.183149886354061 7.20630466764891e-08 NA NA NA hsa-miR-505-5p PRKCA 0.0973008785018434 0.183209581426791 -0.289954367502515 3.07027667899011e-05 mirMAP -0.102672793703942 0.00160299774148607 NA NA NA hsa-miR-548b-3p PRKCA 0.340474544210108 0.00224491592019745 -0.289954367502515 3.07027667899011e-05 PITA;miRNATAP -0.107410539931332 3.63814329290144e-07 NA NA NA hsa-miR-550a-3p PRKCA 0.311518294008363 0.0015285640451888 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.135787662750574 7.76840887594873e-09 NA NA NA hsa-miR-590-3p PRKCA 0.312951515438396 0.000480455423843996 -0.289954367502515 3.07027667899011e-05 PITA;miRanda;mirMAP;miRNATAP -0.152536946782924 3.436144371863e-09 NA NA NA hsa-miR-93-3p PRKCA 0.0778767956494004 0.272224943247293 -0.289954367502515 3.07027667899011e-05 mirMAP -0.146551656012825 2.11995627214635e-05 NA NA NA hsa-miR-155-5p PRKCB 0.969837380981085 5.86551495710056e-15 -0.682239380816002 3.52750339218814e-07 mirMAP -0.235836634520576 1.53174038755186e-07 NA NA NA hsa-miR-195-3p PRKCB 0.100105455903079 0.133362389112338 -0.682239380816002 3.52750339218814e-07 mirMAP -0.359971667645682 5.30224329291627e-05 NA NA NA hsa-miR-200c-3p PRKCB 0.413752622631695 8.6936333715621e-06 -0.682239380816002 3.52750339218814e-07 MirTarget;miRNATAP -0.208521490107408 0.000752162039048593 NA NA NA hsa-miR-23a-3p PRKCB 0.334693010651106 0.00144448147063433 -0.682239380816002 3.52750339218814e-07 mirMAP -0.27145045765466 1.33239615330638e-05 NA NA NA hsa-miR-27a-3p PRKCB 0.303760032895792 0.00457375391189806 -0.682239380816002 3.52750339218814e-07 MirTarget;miRNATAP -0.215141700970757 0.000219945845412233 NA NA NA hsa-miR-450b-5p PRKCB 0.270544879013992 0.00801537838499562 -0.682239380816002 3.52750339218814e-07 miRNATAP -0.161638000758075 0.00497309309812017 NA NA NA hsa-miR-590-3p PRKCB 0.312951515438396 0.000480455423843996 -0.682239380816002 3.52750339218814e-07 mirMAP -0.223842383414072 0.000503630468502308 NA NA NA hsa-miR-320a PRKCG 0.092135599636725 0.243028758989929 -1.05900738460984 1.8225118256495e-06 MirTarget;miRanda -0.531753093228863 0.000615460761538157 NA NA NA hsa-miR-320b PRKCG 0.283477746304177 0.0005953763020907 -1.05900738460984 1.8225118256495e-06 MirTarget;miRanda -0.367797376788092 0.00188611730145367 NA NA NA hsa-miR-320c PRKCG 0.343259124189966 0.000248338401291051 -1.05900738460984 1.8225118256495e-06 MirTarget;miRanda -0.485123776133657 5.54850190547458e-06 NA NA NA hsa-miR-532-3p PRKCG 0.150624483952741 0.0599635132177191 -1.05900738460984 1.8225118256495e-06 miRNATAP -0.329482037092211 0.00954229687515554 NA NA NA hsa-miR-103a-2-5p PRKX -0.0677071239234235 0.496202425310213 -0.234656702391627 0.00431000884646852 mirMAP -0.185614107823291 3.00149445409194e-08 NA NA NA hsa-miR-126-5p PRKX 0.177332403948664 0.0711675116243123 -0.234656702391627 0.00431000884646852 MirTarget;miRNATAP -0.187301575968566 1.30428005782524e-07 NA NA NA hsa-miR-139-5p PRKX -0.647754756897633 2.15378307237163e-06 -0.234656702391627 0.00431000884646852 MirTarget -0.111049071581413 1.00400340749505e-05 NA NA NA hsa-miR-140-3p PRKX -0.123864258867705 0.14796686619449 -0.234656702391627 0.00431000884646852 mirMAP -0.188792670005692 0.000271546600802212 NA NA NA hsa-miR-143-5p PRKX 0.460068066898162 0.000603073392139956 -0.234656702391627 0.00431000884646852 miRNATAP -0.143226065795783 5.12157339907867e-09 NA NA NA hsa-miR-145-5p PRKX 0.108948399943015 0.310032352776693 -0.234656702391627 0.00431000884646852 MirTarget;miRNATAP -0.222996299939014 7.11591241346387e-12 NA NA NA hsa-miR-148a-3p PRKX 0.306821592493439 0.0392356958885949 -0.234656702391627 0.00431000884646852 MirTarget -0.107273294595938 5.70709078555767e-06 NA NA NA hsa-miR-148b-3p PRKX 0.0710353380371513 0.322794068460232 -0.234656702391627 0.00431000884646852 MirTarget -0.256323857849908 1.74249911988869e-06 NA NA NA hsa-miR-148b-5p PRKX 0.127111784487801 0.188731110216917 -0.234656702391627 0.00431000884646852 mirMAP -0.119235002449208 0.000703942471696724 NA NA NA hsa-miR-16-1-3p PRKX 0.346674816118499 1.86447850167636e-05 -0.234656702391627 0.00431000884646852 MirTarget -0.185074407382809 8.05451956693482e-06 NA NA NA hsa-miR-16-2-3p PRKX 0.468816222075619 7.04377763166292e-05 -0.234656702391627 0.00431000884646852 MirTarget;mirMAP -0.198629542094723 6.08018799340144e-13 NA NA NA hsa-miR-181a-5p PRKX -0.178215604431845 0.0700010802255601 -0.234656702391627 0.00431000884646852 mirMAP -0.15106825040288 0.00123868308466424 NA NA NA hsa-miR-181b-5p PRKX 0.0260899284211646 0.768941836912518 -0.234656702391627 0.00431000884646852 mirMAP -0.279522155835593 2.18438847332363e-09 NA NA NA hsa-miR-19a-3p PRKX 0.0466707843731911 0.576818938277755 -0.234656702391627 0.00431000884646852 miRNATAP -0.124806422804607 0.00303499773107959 NA NA NA hsa-miR-19b-3p PRKX -0.0138427450847924 0.856506310673067 -0.234656702391627 0.00431000884646852 miRNATAP -0.176601983702423 0.000423189660787107 NA NA NA hsa-miR-218-5p PRKX -0.534287404275829 0.00308322441944796 -0.234656702391627 0.00431000884646852 miRNATAP -0.149237768038395 7.9885738260038e-17 NA NA NA hsa-miR-23b-3p PRKX 0.0476610245860094 0.630277683372344 -0.234656702391627 0.00431000884646852 mirMAP -0.19980057428488 1.12685512772789e-07 NA NA NA hsa-miR-26a-2-3p PRKX 0.26597501648608 0.000796444054340143 -0.234656702391627 0.00431000884646852 mirMAP -0.134802899007735 0.00144817261413182 NA NA NA hsa-miR-27b-3p PRKX -0.0599187745243146 0.58208143475992 -0.234656702391627 0.00431000884646852 MirTarget;miRNATAP -0.131368529715051 0.000112253562391766 NA NA NA hsa-miR-29a-3p PRKX -0.224140851576083 0.0349516103550236 -0.234656702391627 0.00431000884646852 mirMAP -0.123863087459517 0.00269106286247111 NA NA NA hsa-miR-29b-3p PRKX -0.178522712044497 0.0856106432165465 -0.234656702391627 0.00431000884646852 mirMAP -0.173413136803338 1.43367881926089e-06 NA NA NA hsa-miR-29c-3p PRKX -0.372180390387259 0.00202634431973208 -0.234656702391627 0.00431000884646852 mirMAP -0.117968228195243 0.000111258392242527 NA NA NA hsa-miR-323b-3p PRKX -0.254474308066903 0.15651329633719 -0.234656702391627 0.00431000884646852 mirMAP -0.121471311882467 3.96651880271252e-11 NA NA NA hsa-miR-335-3p PRKX 0.34540584335595 0.00043848660222294 -0.234656702391627 0.00431000884646852 mirMAP -0.251127596351802 4.37732142750105e-13 NA NA NA hsa-miR-33a-5p PRKX 0.0197996465877179 0.86830656038963 -0.234656702391627 0.00431000884646852 mirMAP -0.10391806415594 0.000224291426001427 NA NA NA hsa-miR-375 PRKX -0.0268401141324031 0.858358101444697 -0.234656702391627 0.00431000884646852 miRNAWalker2_validate;miRanda -0.115694809758222 1.47169050286958e-07 NA NA NA hsa-miR-409-3p PRKX 0.00456692516634361 0.974143243758506 -0.234656702391627 0.00431000884646852 mirMAP -0.224291050887867 1.11264823229881e-22 NA NA NA hsa-miR-432-5p PRKX -0.214242438141977 0.166186087759946 -0.234656702391627 0.00431000884646852 miRNATAP -0.167538839875961 1.88486920036252e-15 NA NA NA hsa-miR-450b-5p PRKX 0.270544879013992 0.00801537838499562 -0.234656702391627 0.00431000884646852 mirMAP -0.102960665807675 0.00204956194458089 NA NA NA hsa-miR-495-3p PRKX -0.421982588962504 0.00504424038526901 -0.234656702391627 0.00431000884646852 MirTarget -0.178449482518289 2.15988126863328e-16 NA NA NA hsa-miR-539-5p PRKX -0.326485413953598 0.0554453076411246 -0.234656702391627 0.00431000884646852 mirMAP -0.144010574364934 5.81971773063992e-14 NA NA NA hsa-miR-542-3p PRKX 0.0835995677900829 0.403838744494071 -0.234656702391627 0.00431000884646852 mirMAP -0.154230342664725 3.08460179424332e-05 NA NA NA hsa-miR-590-3p PRKX 0.312951515438396 0.000480455423843996 -0.234656702391627 0.00431000884646852 mirMAP -0.149486589624489 6.13061408540306e-05 NA NA NA hsa-miR-625-3p PRKX -0.0638840950852737 0.547354471747105 -0.234656702391627 0.00431000884646852 mirMAP -0.214773811263468 1.78365907489191e-11 NA NA NA hsa-miR-935 PRKX -0.277848050075718 0.02166231531395 -0.234656702391627 0.00431000884646852 mirMAP -0.134302509100497 1.78644955549975e-06 NA NA NA hsa-miR-124-3p RAC2 -0.506026514549291 0.0078056370358648 0.543102090563642 6.32748728882766e-07 mirMAP -0.16328824721264 5.64768337601236e-11 NA NA NA hsa-miR-129-5p RAC2 -0.567133990117126 0.00116152215679936 0.543102090563642 6.32748728882766e-07 miRanda -0.163216019318866 3.88418743152648e-09 NA NA NA hsa-miR-491-5p RAC2 -0.749881113074983 8.22859263179194e-09 0.543102090563642 6.32748728882766e-07 miRanda -0.143477171929978 6.8541464600559e-05 NA NA NA hsa-miR-125a-5p RAC3 -0.0833349424517387 0.325440200253607 -0.0694477011024395 0.398923087359439 PITA -0.255720823416584 1.87026446294698e-07 NA NA NA hsa-miR-30c-2-3p RAC3 -0.18630560418806 0.0313113706136533 -0.0694477011024395 0.398923087359439 miRNAWalker2_validate -0.340394704089941 3.11880878701484e-16 NA NA NA hsa-miR-590-3p RAC3 0.312951515438396 0.000480455423843996 -0.0694477011024395 0.398923087359439 miRanda -0.139701651516001 0.000218392196649336 NA NA NA hsa-miR-671-5p RAC3 0.379677704170736 0.000129391032677459 -0.0694477011024395 0.398923087359439 miRNATAP -0.228245307641295 7.53346315814315e-12 NA NA NA hsa-miR-592 RHOA 0.0170005651576508 0.876633091134809 0.0216749062113539 0.702384833178432 PITA -0.113898466932858 4.37696740723643e-26 NA NA NA hsa-miR-139-5p ROCK1 -0.647754756897633 2.15378307237163e-06 -0.015856028186529 0.800759474576457 PITA;miRanda -0.121585507119699 1.65803025551636e-12 20951699 The microRNA miR 139 suppresses metastasis and progression of hepatocellular carcinoma by down regulating Rho kinase 2 metastasis;progression liver cancer hsa-miR-146a-5p ROCK1 0.148942451196282 0.114229072828724 -0.015856028186529 0.800759474576457 miRNAWalker2_validate;miRTarBase -0.12114331650405 1.12457470933559e-06 26306811;18174313 In mechanic analyses we found that miR-146a inhibited the basal level of Rho-associated coiled-coil containing protein kinase 1 ROCK1 expression by targeting its 3'UTR and an inverse correlation of expression between miR-146a and ROCK1 was observed;Transfection of mir-146a which perpetually express the miRNA suppressed >82% of the expression of the targeted protein-coding gene ROCK1 in androgen-independent PC3 cells consequently markedly reducing cell proliferation invasion and metastasis to human bone marrow endothelial cell monolayers; Given that ROCK1 is one of the key kinases for the activation of hyaluronan HA-mediated HRPC transformation in vivo and in PC3 cells mir-146a may function as a tumor-suppressor gene in modulating HA/ROCK1-mediated tumorigenecity in androgen-dependent prostate cancer ;metastasis prostate cancer;prostate cancer hsa-miR-153-3p ROCK1 -0.173449510253619 0.0654368045743418 -0.015856028186529 0.800759474576457 MirTarget -0.115404035009362 6.9760181615191e-06 NA NA NA hsa-miR-582-5p ROCK1 -0.215764335500665 0.0760892640434509 -0.015856028186529 0.800759474576457 PITA -0.155407355121203 4.19917688202289e-17 NA NA NA hsa-miR-592 ROCK1 0.0170005651576508 0.876633091134809 -0.015856028186529 0.800759474576457 MirTarget;PITA -0.177547536366214 1.00893957197203e-17 NA NA NA hsa-miR-664a-3p ROCK1 0.0413918462467198 0.611334357897022 -0.015856028186529 0.800759474576457 mirMAP -0.15524503484369 1.03651332518006e-07 NA NA NA hsa-let-7a-3p ROCK2 0.0530563276543763 0.370749834463566 -0.0374555407529682 0.649956607700197 mirMAP -0.198208326654429 0.00192274343048344 NA NA NA hsa-miR-500a-5p ROCK2 0.0634452729978863 0.396072382601677 -0.0374555407529682 0.649956607700197 mirMAP -0.18007912239615 7.14611706912205e-05 NA NA NA hsa-miR-346 RUVBL1 -0.577786425963268 2.10883270131593e-09 0.152054509008694 0.0015236002167294 miRanda -0.133919799728295 3.65422570730331e-17 NA NA NA hsa-miR-195-3p SFRP2 0.100105455903079 0.133362389112338 -2.34883190639562 2.46356548815388e-21 miRNATAP -0.502555072760763 0.00396569500679316 NA NA NA hsa-miR-199a-5p SFRP2 0.174889610847968 0.0900027418912454 -2.34883190639562 2.46356548815388e-21 miRanda -0.34944218926732 0.0016121598292507 NA NA NA hsa-miR-199b-5p SFRP2 0.436298593972862 0.00200225454383871 -2.34883190639562 2.46356548815388e-21 miRanda -0.415923442275379 1.24943887023382e-07 NA NA NA hsa-miR-450b-5p SFRP2 0.270544879013992 0.00801537838499562 -2.34883190639562 2.46356548815388e-21 PITA;miRNATAP -0.418121540223271 0.000188212630364817 27494869 Furthermore we demonstrated that miR-450b-5p directly bound the 3'-UTRs of SFRP2 and SIAH1 and activated Wnt/β-Catenin signaling colorectal cancer hsa-miR-455-5p SFRP2 0.332224239762 0.0106491358056238 -2.34883190639562 2.46356548815388e-21 miRanda -0.32559364849315 0.000167500325130147 NA NA NA hsa-miR-590-3p SFRP2 0.312951515438396 0.000480455423843996 -2.34883190639562 2.46356548815388e-21 miRanda -0.761347125461889 8.36160870715061e-10 NA NA NA hsa-miR-129-5p SFRP4 -0.567133990117126 0.00116152215679936 0.837599072525803 4.88438094021192e-08 miRanda -0.175321879354888 9.76199357711033e-06 NA NA NA hsa-miR-346 SFRP4 -0.577786425963268 2.10883270131593e-09 0.837599072525803 4.88438094021192e-08 miRanda;miRNATAP -0.391247031336864 1.70313037083912e-08 NA NA NA hsa-miR-193b-3p SIAH1 0.0766333116224072 0.324723824453143 0.00581809385550081 0.890923204236709 miRNATAP -0.135133349463128 3.54935240682215e-14 NA NA NA hsa-miR-200b-3p SIAH1 0.245768526504511 0.0580744465744737 0.00581809385550081 0.890923204236709 TargetScan -0.116917198908622 9.27165175527678e-32 NA NA NA hsa-miR-30a-3p SIAH1 0.0655410309550977 0.509541256241954 0.00581809385550081 0.890923204236709 miRNATAP -0.201715217879709 4.71664770108326e-34 NA NA NA hsa-miR-421 SIAH1 -0.171573235029879 0.0518112933651029 0.00581809385550081 0.890923204236709 miRanda -0.11373692685153 3.28392408036691e-14 NA NA NA hsa-miR-488-5p SIAH1 -0.385755602369049 7.99431673275965e-08 0.00581809385550081 0.890923204236709 miRNATAP -0.102522963028622 1.14924955661141e-07 NA NA NA hsa-miR-532-5p SIAH1 0.0263466708637097 0.75763006039876 0.00581809385550081 0.890923204236709 PITA;miRNATAP -0.127320129384503 1.86784904104102e-11 NA NA NA hsa-miR-130b-3p SKP1 0.503911467685709 9.46590588950823e-08 -0.190804442552597 0.000494555589918693 MirTarget -0.122601330293596 1.00997929262659e-19 NA NA NA hsa-miR-15a-5p SMAD3 0.142658985373611 0.0536219185009004 -0.0461774445110805 0.498736701509296 MirTarget -0.137331699251882 0.000744677232811907 NA NA NA hsa-let-7f-1-3p SMAD4 0.110713086694053 0.21484524300518 -0.0480651463186925 0.333853878951855 mirMAP -0.112094816748955 3.72889244611741e-12 NA NA NA hsa-miR-106a-5p SMAD4 0.110074064773897 0.13045815990621 -0.0480651463186925 0.333853878951855 mirMAP;miRNATAP -0.104621077552926 8.44868166811478e-07 NA NA NA hsa-miR-125a-5p SMAD4 -0.0833349424517387 0.325440200253607 -0.0480651463186925 0.333853878951855 miRTarBase -0.108065804207878 3.53979250363128e-07 NA NA NA hsa-miR-126-5p SMAD4 0.177332403948664 0.0711675116243123 -0.0480651463186925 0.333853878951855 mirMAP -0.108936745818454 1.3197797103689e-12 NA NA NA hsa-miR-146a-5p SMAD4 0.148942451196282 0.114229072828724 -0.0480651463186925 0.333853878951855 miRNAWalker2_validate;miRTarBase -0.12304740941773 1.20646297394653e-15 21982769;27438138;22020746 The results indicated that miR-146a regulated the sensitivity of HCC cells to the cytotoxic effects of IFN-α through SMAD4 suggesting that this miRNA could be suitable for prediction of the clinical response and potential therapeutic target in HCC patients on IFN-based therapy;SMAD4 was identified as a miR-146a target and was downregulated in BARF1-expressing cells whereas SMAD4 expression was restored by anti-miR-146a; Knockdown of BARF1 in YCCEL1 cells upregulated SMAD4 and this effect was reversed by miR-146a overexpression; In stomach cancer tissues miR-146a was expressed at higher levels and more frequent NFκB nuclear positivity immunohistochemically but not of SMAD4 nuclear loss was found in the EBV-positive group compared with the EBV-negative group; In conclusion EBV-encoded BARF1 promotes cell proliferation in stomach cancer by upregulating NFκB and miR-146a and downregulating SMAD4 thereby contributing to EBV-induced stomach cancer progression;Increased miR 146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis; Using target prediction algorithms luciferase reporter assay and Western blot assay SMAD family member 4 SMAD4 was identified as a target gene of miR-146a in gastric cancer; Moreover an inverse correlation was observed between the expression of SMAD4 mRNA and miR-146a in gastric cancer tissues R=-0.731 P=0.039 Pearson's correlation; Taken together our results provide important evidence that miR-146a can directly target SMAD4 and suggest that miR-146a may play a role in the development of gastric cancer by modulating cell proliferation and apoptosis drug resistance;progression; liver cancer;gastric cancer;gastric cancer hsa-miR-146b-5p SMAD4 0.441078059667297 0.000237619929889385 -0.0480651463186925 0.333853878951855 PITA;miRanda;miRNATAP -0.147840875731319 5.77711341775598e-35 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-150-5p SMAD4 0.0645271721519611 0.513295658828718 -0.0480651463186925 0.333853878951855 mirMAP -0.140099817794943 5.26740000263147e-21 NA NA NA hsa-miR-155-5p SMAD4 0.969837380981085 5.86551495710056e-15 -0.0480651463186925 0.333853878951855 miRNAWalker2_validate -0.118153900154786 3.91770964859782e-27 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-199a-5p SMAD4 0.174889610847968 0.0900027418912454 -0.0480651463186925 0.333853878951855 miRNAWalker2_validate;miRTarBase;miRanda -0.100954911386107 9.72901116309968e-13 NA NA NA hsa-miR-2355-5p SMAD4 0.00808596988211185 0.916165501155096 -0.0480651463186925 0.333853878951855 MirTarget -0.138601553013193 2.31055516575799e-12 NA NA NA hsa-miR-27b-3p SMAD4 -0.0599187745243146 0.58208143475992 -0.0480651463186925 0.333853878951855 MirTarget -0.109946664636984 4.80354118087017e-14 NA NA NA hsa-miR-28-3p SMAD4 0.139444423971018 0.0811187936164314 -0.0480651463186925 0.333853878951855 mirMAP -0.156323645997406 2.52937793682202e-11 NA NA NA hsa-miR-28-5p SMAD4 0.104003572105781 0.153594705579534 -0.0480651463186925 0.333853878951855 miRanda;miRNATAP -0.108665505252487 4.7241141004314e-07 NA NA NA hsa-miR-29b-2-5p SMAD4 -0.26834261955727 0.00453760540520233 -0.0480651463186925 0.333853878951855 MirTarget -0.124752999421755 6.21375734890817e-16 NA NA NA hsa-miR-30a-5p SMAD4 -0.062942936611238 0.513851954700252 -0.0480651463186925 0.333853878951855 mirMAP -0.197157226879658 9.57330245001194e-16 NA NA NA hsa-miR-30c-5p SMAD4 -0.0469114469943097 0.565934557464627 -0.0480651463186925 0.333853878951855 mirMAP -0.106012380191749 4.33019792404505e-06 NA NA NA hsa-miR-30d-5p SMAD4 -0.0607010868720046 0.471410043548794 -0.0480651463186925 0.333853878951855 mirMAP -0.103563321543632 8.62191088751512e-05 NA NA NA hsa-miR-335-3p SMAD4 0.34540584335595 0.00043848660222294 -0.0480651463186925 0.333853878951855 mirMAP -0.114385410785847 4.0809889989156e-14 NA NA NA hsa-miR-34a-5p SMAD4 0.143472919835524 0.211283228567057 -0.0480651463186925 0.333853878951855 miRNATAP -0.161359767712972 2.62012161311457e-40 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-361-5p SMAD4 0.0107519600643302 0.882230614095565 -0.0480651463186925 0.333853878951855 mirMAP -0.199229708620127 4.10990421373243e-16 NA NA NA hsa-miR-425-5p SMAD4 -0.0412837711174561 0.682284485592858 -0.0480651463186925 0.333853878951855 mirMAP -0.109670741700584 4.36243779451545e-13 NA NA NA hsa-miR-589-5p SMAD4 -0.0382528919634639 0.5844074434222 -0.0480651463186925 0.333853878951855 miRNATAP -0.113352850721085 3.13434103908252e-06 NA NA NA hsa-miR-664a-3p SMAD4 0.0413918462467198 0.611334357897022 -0.0480651463186925 0.333853878951855 MirTarget -0.176780902353316 2.67661742767344e-23 NA NA NA hsa-miR-664a-5p SMAD4 0.0825994937558296 0.264421724444089 -0.0480651463186925 0.333853878951855 mirMAP -0.144950554671858 1.05670261458917e-13 NA NA NA hsa-miR-7-1-3p SMAD4 -0.0894475316162393 0.37322359785108 -0.0480651463186925 0.333853878951855 mirMAP -0.107525661059734 8.73423192056203e-14 NA NA NA hsa-miR-30a-3p TBL1XR1 0.0655410309550977 0.509541256241954 -0.0347687857586667 0.458932257066051 mirMAP -0.110180124417564 9.6046637919592e-13 NA NA NA hsa-miR-133a-3p TCF7 -0.335058908302964 0.0180402783121034 0.537678341711831 2.21206848061359e-08 MirTarget -0.133465626682229 6.46479900533426e-06 NA NA NA hsa-miR-491-5p TCF7 -0.749881113074983 8.22859263179194e-09 0.537678341711831 2.21206848061359e-08 MirTarget;PITA;miRanda;miRNATAP -0.12657748033719 7.00877151348223e-05 NA NA NA hsa-miR-9-5p TCF7 -0.125377971246422 0.269896477802284 0.537678341711831 2.21206848061359e-08 miRNATAP -0.924544853027554 2.458116497836e-25 NA NA NA hsa-miR-106a-5p TCF7L1 0.110074064773897 0.13045815990621 0.0471428239639451 0.548536470142762 MirTarget -0.174727568301223 0.000129196036094053 NA NA NA hsa-miR-129-5p TCF7L1 -0.567133990117126 0.00116152215679936 0.0471428239639451 0.548536470142762 miRanda -0.103152195739639 1.31187865675028e-08 NA NA NA hsa-miR-132-3p TCF7L1 -0.178379362833856 0.13335200877129 0.0471428239639451 0.548536470142762 MirTarget;miRNATAP -0.265755545805364 4.23721027854548e-23 NA NA NA hsa-miR-142-5p TCF7L1 0.434884875454107 0.000575570345702788 0.0471428239639451 0.548536470142762 PITA -0.131858426628803 7.09338535901759e-08 NA NA NA hsa-miR-15b-3p TCF7L1 0.690804403863844 8.48784755123775e-09 0.0471428239639451 0.548536470142762 miRNATAP -0.13659993264046 8.20161812269724e-08 NA NA NA hsa-miR-185-3p TCF7L1 -0.133219014400353 0.255713818728239 0.0471428239639451 0.548536470142762 MirTarget -0.148346187958029 2.12162137870587e-08 NA NA NA hsa-miR-200b-3p TCF7L1 0.245768526504511 0.0580744465744737 0.0471428239639451 0.548536470142762 miRNAWalker2_validate -0.153132836949329 3.06712096063221e-10 NA NA NA hsa-miR-204-5p TCF7L1 -0.288588537398065 0.113371226435822 0.0471428239639451 0.548536470142762 MirTarget;miRNATAP -0.108337925401206 1.98969729288253e-10 NA NA NA hsa-miR-20b-5p TCF7L1 0.144541062989476 0.0992042333556543 0.0471428239639451 0.548536470142762 MirTarget -0.157777488163339 4.16081830129186e-05 NA NA NA hsa-miR-212-3p TCF7L1 -0.014112941209349 0.918360379512974 0.0471428239639451 0.548536470142762 MirTarget;miRNATAP -0.216717600867473 3.825080351515e-23 NA NA NA hsa-miR-30a-3p TCF7L1 0.0655410309550977 0.509541256241954 0.0471428239639451 0.548536470142762 miRNATAP -0.210987716286969 2.48336971812046e-07 NA NA NA hsa-miR-326 TCF7L1 -0.631050656251074 8.83643450601471e-05 0.0471428239639451 0.548536470142762 miRanda -0.111009344906461 6.06787029510024e-09 NA NA NA hsa-miR-330-5p TCF7L1 -0.262932095995605 0.0465226565966658 0.0471428239639451 0.548536470142762 miRanda -0.230652687470906 4.06495126751103e-24 NA NA NA hsa-miR-107 TCF7L2 -0.121070851008387 0.198381281894242 -0.169493690259988 0.00235870535897673 miRanda -0.126445676902046 4.16352845674498e-08 NA NA NA hsa-miR-132-3p TCF7L2 -0.178379362833856 0.13335200877129 -0.169493690259988 0.00235870535897673 miRNATAP -0.107689300812064 3.26074128955906e-09 NA NA NA hsa-miR-148b-3p TCF7L2 0.0710353380371513 0.322794068460232 -0.169493690259988 0.00235870535897673 miRNAWalker2_validate -0.154144567529488 3.05499339886011e-06 NA NA NA hsa-miR-155-5p TCF7L2 0.969837380981085 5.86551495710056e-15 -0.169493690259988 0.00235870535897673 MirTarget;miRNATAP -0.147494312061351 3.43788863371807e-21 NA NA NA hsa-miR-15b-3p TCF7L2 0.690804403863844 8.48784755123775e-09 -0.169493690259988 0.00235870535897673 miRNATAP -0.136471313034686 1.07965482820021e-16 NA NA NA hsa-miR-181b-5p TCF7L2 0.0260899284211646 0.768941836912518 -0.169493690259988 0.00235870535897673 MirTarget;miRNATAP -0.147871033726242 3.10025609003929e-07 NA NA NA hsa-miR-24-1-5p TCF7L2 0.0305643742115347 0.759111089471876 -0.169493690259988 0.00235870535897673 MirTarget -0.109773333016932 9.33796108723918e-08 NA NA NA hsa-miR-26a-5p TCF7L2 0.033823776747294 0.726610414342369 -0.169493690259988 0.00235870535897673 miRNATAP -0.106428140822691 3.82168973799068e-05 NA NA NA hsa-miR-664a-3p TCF7L2 0.0413918462467198 0.611334357897022 -0.169493690259988 0.00235870535897673 MirTarget -0.17509844136631 8.55511209304056e-12 NA NA NA hsa-miR-942-5p TCF7L2 0.331570745524138 0.00475398014468334 -0.169493690259988 0.00235870535897673 MirTarget -0.11337016754409 1.02099474466474e-10 NA NA NA hsa-miR-99b-3p TCF7L2 0.0339709556778862 0.745836688043877 -0.169493690259988 0.00235870535897673 MirTarget;miRNATAP -0.12950590512435 1.24987871478962e-10 NA NA NA hsa-miR-125a-5p TP53 -0.0833349424517387 0.325440200253607 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate;miRTarBase;miRanda -0.375445863722298 1.2184854773952e-16 26389681;21777146;23079745 Mechanistically inactivation of miR-125a during cervical carcinogenesis was caused by HPV suppression of p53 expression;In addition wild-type p53 mRNA and protein expression was increased by hsa-miR-125a-5p overexpression; Moreover blocking wild-type p53 attenuated the effect of hsa-miR-125a-5p on apoptosis; In loss-of-function experiments wild-type p53 mRNA and protein expression was decreased by blocking hsa-miR-125a-5p; The effect of hsa-miR-125a-5p inhibitor on apoptosis was also weakened by blocking wild-type p53;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity tumorigenesis;; cervical and endocervical cancer;lung cancer;liver cancer hsa-miR-125b-5p TP53 -0.0119698382910496 0.890233923197358 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate;miRTarBase -0.294628443669371 1.07324994036762e-07 24169356;24846940;26335100;24137477;26686386;24402874;21399871;23585871;24762088;23079745 MiR 125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK independent pathways; Further studies reveal that p53 is regulated by miR-125b; However downregulation of the endogenous miR-125b also results in p53-independent apoptotic pathway leading to apoptosis in p53 mutated U251 cells and p53 knockdown U87 cells;The results revealed that hsa-miR-125b may regulate multiple biological processes and signal transduction pathways and drug-resistant occurrence is associated with cell proliferation cell apoptosis cell cycle and signaling pathways including MAPK Wnt and p53;The carboxy terminal domain of connexin 43 CT Cx43 modulates the expression of p53 by altering miR 125b expression in low grade human breast cancers; In addition CT-Cx43 was exogenously expressed in the breast cancer-derived cell line MCF-7 and its effect on the expression of miR-125b and its downstream target p53 were evaluated as well as its effect on cellular proliferation and death using MTT and LDH assays respectively; Interestingly we found that miR-125b a negative regulator of p53 exhibited an inverse expression relationship with CT-Cx43 in the breast cancer samples tested;TP53 and hsa-miR-125b were observed to form a self-adaptation association;In this study we have investigated the delivery and transfection of wild-type wt- p53 and microRNA-125b miR-125b expressing plasmid DNA in SK-LU-1 human lung adenocarcinoma cells as well as in KrasG12D/p53fl/fl KP genetically engineered mouse model of lung cancer;miR-34a is directly regulated by p53 and acts as tumor suppressor while miR-125b plays a significant role in immune response and apoptosis;In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of p53 protein in human colorectal cancer cells;In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b;A stable overexpression of miR-125b in human melanoma cell line Mel-Juso resulted in a G0/G1 cell cycle block and emergence of large cells expressing senescence markers: senescence-associated beta-galactosidase p21 p27 and p53;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity; To show the clinical significance of these findings mutations in the DNA binding domain of p53 and promoter methylation of miR-125b were investigated; Four out of nine patients with induced SIRT7 carried mutations in the p53 gene and one patient showed hypermethylation of the miR-125b promoter region ;;;;;immune resistance;;;; glioblastoma;gastric cancer;breast cancer;pancreatic cancer;lung cancer;cervical and endocervical cancer;colorectal cancer;prostate cancer;melanoma;liver cancer hsa-miR-150-5p TP53 0.0645271721519611 0.513295658828718 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate -0.156281214913021 3.09404029899862e-06 23747308;23228962 miR 150 promotes the proliferation of lung cancer cells by targeting P53; Here we demonstrate that miR-150 is aberrantly upregulated in lung cancer tissue and negatively correlates with the expression of the proapoptotic gene p53 but not EGR2; We show that miR-150 specifically targets the 3'-UTR of p53 and regulates its expression; Inhibition of miR-150 effectively delays cell proliferation and promotes apoptosis accompanied by increased p53 protein expression;miR-150 and miR-3940-5p were found to be significantly downregulated in p53 IHC-positive NSCLC cases and were negatively correlated with p53 mRNA; miR-150 and miR-3940-5p may affect p53 expression through a direct or indirect pathway ; lung cancer;lung squamous cell cancer hsa-miR-221-3p TP53 -0.0109507285071775 0.936440693394519 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate -0.143405645468124 6.89189438710031e-10 20880178;24324033 Circulating miR 221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression; The correlation between miR-221 levels and protein levels of p53 CEA ER and PR clinicopathological features or overall survival was analyzed; The immunohistochemistry analysis demonstrates a significant correlation between plasma miR-221 level and p53 expression; The direct amplification of plasma miR-221 can be used as a potential noninvasive molecular marker for diagnosis and prognosis of CRC and is correlated with p53 expression;Interestingly miR-221 can activate the p53/mdm2 axis by inhibiting MDM2 and in turn p53 activation contributes to miR-221 enhanced expression; Moreover by modulating the p53 axis miR-221 impacts cell-cycle progression and apoptotic response to doxorubicin in hepatocellular carcinoma-derived cell lines; These data were confirmed in clinical specimens of hepatocellular carcinoma in which elevated miR-221 expression was associated with the simultaneous presence of wild-type p53 and DNA hypomethylation poor survival;worse prognosis;progression;drug resistance colorectal cancer;liver cancer hsa-miR-222-3p TP53 0.107117065575197 0.423818119725697 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate -0.142653482163308 1.2671214916531e-09 NA NA NA hsa-miR-30d-5p TP53 -0.0607010868720046 0.471410043548794 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate -0.336903694979927 3.32137008004591e-09 NA NA NA hsa-miR-324-5p TP53 0.0183370482495953 0.842996782677271 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate -0.170645382602635 1.21583558752455e-06 NA NA NA hsa-miR-338-3p TP53 -0.39963704679384 0.0034410643220691 0.346312114104146 1.42081328137217e-05 miRanda -0.117560999445537 4.2049029410775e-06 NA NA NA hsa-miR-34a-5p TP53 0.143472919835524 0.211283228567057 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate -0.127236433475415 7.74576992902642e-06 23155233;19773441;25572695;25123132;22438124;21702042;22292433;21383543;25982144;19443717;26790955;24642471;22198213;25362853;23036084;19421141;24444609;20186752;22457788;27186405;21731696;19736307;26879132;23569431;25771001;23292869;24209638;24957404;21240262;24503183;22102859;18803879;24630988;25895459;25894979;19714243;26944831;19921694;21909380;25789847;23450486;24402874;24337371;18497571;25490093;22593438;24528540;20145172;23349340;25038915;21321636;23632240;23624843;19029026;20309940;22810507;23862748;25932212;18834855;21225432 The high miR-34a expression level in the cells after irradiation at 60 Gy reduced the p53 expression level;MicroRNA-34a miR-34a is a transcriptional target of p53 that is down-regulated in some cancer cell lines; Analysis of human specimens showed that miR-34a expression is down-regulated in glioblastoma tissues as compared with normal brain and in mutant p53 gliomas as compared with wild-type p53 gliomas;For this purpose cell viability assay Realtime quantitative PCR for mRNA quantification western blot for essential protein expression p53 silencing by shRNA and miR-34a knockdown were performed in the present study; PRE also elevated p53 protein and triggered miR-34a expression;As expected p53 loss caused downregulation of established p53 targets e.g p21 and miR-34 family and increased proliferation in both luminal and basal-like cell lines;Moreover re-expression of miR-34a by transfection in NSCLC cells resulted in inhibition of cell growth and invasiveness induction of apoptosis and enhanced p53 activity;MiR 34a chemosensitizes bladder cancer cells to cisplatin treatment regardless of p53 Rb pathway status; MiR-34a is a downstream effector of p53 that has been shown to target several molecules associated with cell cycle and cell survival pathways; As alterations in these pathways are frequent in muscle invasive transitional cell carcinoma of the bladder MI-TCC for example mutation or loss of p53 and Rb the goal of this study was to determine whether manipulation of miR-34a expression levels could abrogate the effect of these alterations and sensitize bladder cancer cells to chemotherapy;Reporter assay further showed that NF-kappaB-induced miR-34a transcriptional activity was reduced by p53 impairment; And wildtype p53 is responsible for NF-kappaB-mediated miR-34a transcriptional activity but not for NF-kappaB binding;Recently miR-34 family has been shown to be part of the p53 pathway which is frequently involved in lung cancer and the expression of miR-34 has been reported to be regulated by DNA methylation;5 Aminolevulinic acid mediated sonodynamic therapy induces anti tumor effects in malignant melanoma via p53 miR 34a Sirt1 axis; Therefore the p53 miR-34a and SIRT1 constituted a positive feedback loop;miR-34a expression could be increased in Y79 cells but not Weri-Rb1 cells after p53 activation; This differential regulation was not caused by genomic alterations at the miR-34a p53 binding site or mature gene;Conversely kallistatin stimulated expression of the tumorigenic suppressors miR-34a and p53;Members of the miR-34 family are induced by the tumor suppressor p53 and are known to inhibit epithelial-to-mesenchymal transition EMT and therefore presumably suppress the early phases of metastasis;MicroRNA-34a miR-34a a transcriptional target of p53 is a well-known tumor suppressor gene; Moreover we found that miR-34a was downregulated in 25 of 40 62.5% colon cancer tissues as compared with the adjacent normal colon tissues and that the expression of miR-34a was correlated with the DNA-binding activity of p53;Ectopic expression of miR-34a-5p in p53 wild-type colon cancer cell HCT116 significantly inhibited cell growth migration invasion and metastasis; miR-34a-5p induced cell apoptosis cell cycle arrest at G1 phase and p53 transcription activity in HCT116 cells but not in the HCT116 p53 knockout p53-/- cells; miR-34a-5p significantly suppressed the HCT116 growth in vivo whereas it showed no effect on the HCT116 p53-/- xenograft indicating that the growth-inhibiting effect by miR-34a-5p was dependent on p53;microRNA 34a sensitizes lung cancer cell lines to DDP treatment independent of p53 status; However the precise biological role of miR-34a in p53 deficient lung cancer cell lines remains largely elusive; Overall in this study we found the proliferation inhibition function of miR-34a in vitro in lung cancer cell lines is p53 independent and also demonstrated the combination therapeutic potential of miR-34a and DDP in lung cancer cell lines;In particular mammalian miR-34 is upregulated by p53 in response to radiation but little is known about the role of this miRNA in vivo; These findings show a role for mir-34 in both apoptotic and non-apoptotic cell death in vivo much like that of cep-1 the C elegans p53 homolog;Tumor-suppressive miR-34a a direct target of p53 has been shown to target several molecules of cell survival pathways; Here we show that capsaicin-induced oxidative DNA damage culminates in p53 activation to up-regulate expression of miR-34a in non-small cell lung carcinoma NSCLC cells;Accumulating evidence suggests that miR-34a as a key mediator of p53 tumor suppression is aberrantly expressed in human cancers; Bioinformatics analysis produced a protein-protein interaction network which revealed that the p53 signaling pathway and cell cycle pathway were two major hubs containing most of the proteins regulated by miR-34a;Studies have demonstrated that miR-34a which is a direct target of the p53 tumor suppressor gene functions as a tumor suppressor and is associated with the tumor growth and metastasis of various human malignances;Knockdown of oncoprotein E6 expression of human papillomavirus in SiHa and HeLa cells by siRNAs lead to an increased protein level of p53 decreased level of miR-34a as well as reduced Warburg effect;miR-34a is known as a p53 regulated tumor suppressor microRNA in many cancer types;In addition in patients with sufficient tumor tissue we assessed p53 mutations and the methylation status of the MIRN34A gene promoter region and correlated these findings with miR-34a expression; Patients with both p53 mutations and low miR-34a levels had the highest probability of relapse P = 0.001;Particularly miR-34a has been revealed to be a direct transcriptional target of p53 which is frequently mutated in epithelial ovarian carcinomas especially in high grade serous cancer; The aim of this study was to investigate the clinical relevance of mir34a as well as its promoter methylation in a subset of 133 ovarian cancers with a special focus on the p53 mutation status the dualistic type I and type II ovarian cancer model and the different histotypes; The expression of miR-34a was found lower in type II than in type I cancers p = 0.037 in p53 mutated as compared to p53 wild type cancers p = 0.003 and in high grade compared to in low grade cancers p = 0.028; The inverse association between miR-34a expression and grading p53 mutation status and dualistic tumor type classification together with its prognostic relevance may underline the tumor-suppressive character of miR-34a in ovarian cancer;As a direct target gene of p53 miR-34a has been suggested to mediate the tumor suppressor function of p53;Further studies indicated that PEG4000-TQ-Nps could significantly increase the expression of miR-34a through p53;Downregulation of miR 34a in breast tumors is not associated with either p53 mutations or promoter hypermethylation while it correlates with metastasis; Recent studies have shown that p53 upregulates miR-34 family leading to direct repression of several key oncogenes; In this study expression of mature miR-34a in breast tumors with wild-type p53 was investigated in order to find any correlation between dysregulation of miR-34a expression and breast cancer; In about 40 % of the wild-type p53 samples miR-34a was significantly downregulated; This study has provided evidence that miR-34a expression can be affected in a significant proportion of breast tumors independent of p53; Knowledge of miR-34a status may provide additional useful information regarding the nature of breast tumors especially when p53 testing does not show any aberration;Among these we found well studied molecules such as the miR-17-92 cluster comprising potent oncogenic microRNA and miR-34 recently found to interact with p53;The results demonstrated that miR-199a and miR-34a could induce the apoptosis of human osteosarcoma cells via p53 signalling pathway;Here we show through expression analysis that miR-34a a p53 target was underexpressed in CD44+ prostate cancer cells purified from xenograft and primary tumors;Members of the miR-34 family have been shown to be transcriptional targets of the tumour suppressor gene P53;Functional genomic analysis highlighted a novel regulatory role of the transcription factor MAZ apart from the known control by p53 on the expression of miR-34a and a number of miR-34a targets; Our analysis for regulatory loops suggest that MAZ and p53 transcription factors co-operate in modulating miR-34a as well as miR-34a targets involved in several cellular pathways;Restoration of tumor suppressor miR 34 inhibits human p53 mutant gastric cancer tumorspheres; MicroRNA miR-34 was recently found to be a direct target of p53 functioning downstream of the p53 pathway as a tumor suppressor; Our results demonstrate that in p53-deficient human gastric cancer cells restoration of functional miR-34 inhibits cell growth and induces chemosensitization and apoptosis indicating that miR-34 may restore p53 function;miR 34 cooperates with p53 in suppression of prostate cancer by joint regulation of stem cell compartment; The miR-34 family was originally found to be a direct target of p53 and is a group of putative tumor suppressors; Here we report that mice with prostate epithelium-specific inactivation of mir-34 and p53 show expansion of the prostate stem cell compartment and develop early invasive adenocarcinomas and high-grade prostatic intraepithelial neoplasia whereas no such lesions are observed after inactivation of either the mir-34 or p53 genes alone by 15 months of age; Consistently combined deficiency of p53 and miR-34 leads to acceleration of MET-dependent growth self-renewal and motility of prostate stem/progenitor cells; Our study provides direct genetic evidence that mir-34 genes are bona fide tumor suppressors and identifies joint control of MET expression by p53 and miR-34 as a key component of prostate stem cell compartment regulation aberrations in which may lead to cancer;The miR-34 family is directly transactivated by tumor suppressor p53 which is frequently mutated in various cancers; however the effect of miR-34a on the ovarian cancer cells remains unclear;The microRNA-34 family miR-34a -34b and -34c have been reported to be tumor suppressor microRNAs miRNAs that are regulated by the TP53 and DNA hypermethylation; To elucidate the roles of miR-34 family in colon carcinogenesis miR-34a/b/c were measured in tumors and adjacent noncancerous tissues from 159 American and 113 Chinese colon cancer patients using quantitative RT-PCR and we examined associations between miR-34a/b/c expression with TNM staging cancer-specific mortality TP53 mutation status and Affymetrix microarray data;Transcription of the three miRNA miR-34 family members was recently found to be directly regulated by p53; Our results demonstrate that miR-34 may restore at least in part the tumor suppressing function of the p53 in p53-deficient human pancreatic cancer cells;p53 status was not correlated with miR-34a;The above results suggest that microRNA-34a is one of the important components of PRIMA-1-induced apoptotic network in the cancer cells harboring mutant p53;MicroRNA-34a miR-34a is a transcriptional target of p53 and is down-regulated in pancreatic cancer;Phytochemical regulation of the tumor suppressive microRNA miR 34a by p53 dependent and independent responses in human breast cancer cells; The tumor suppressive microRNA miR-34a is transcriptionally regulated by p53 and shown to inhibit breast cancer cell proliferation as well as being a marker of increased disease free survival; Human breast cancer cells expressing wild-type MCF-7 or mutant p53 T47D were treated with a concentration range and time course of each phytochemical under conditions of cell cycle arrest as detected by flow cytometry to examine the potential connection between miR-34a expression and their anti-proliferative responses; Our results suggest that miR-34a is an essential component of the anti-proliferative activities of I3C artemisinin and artesunate and demonstrate that both wild-type p53 dependent and independent pathways are responsible for miR-34a induction;Compared with p53 normal group the expression level of miR-34a was significantly lower in p53 deletion group;miR-34a is directly regulated by p53 and acts as tumor suppressor while miR-125b plays a significant role in immune response and apoptosis;The microRNA miR-34 family is a direct transcriptional target of tumor-suppressor TP53 and loss of miR-34 function may impair TP53-mediated cell cycle arrest and apoptosis;It appears that AR-dependent inhibition of p53 resulted in suppression of miR-34a and -34c expression;In this study we evaluated the cascade of events determined by etoposide-induced DNA damage in OS cell lines with different p53 status focusing on methylation status and expression of miR-34a that modulate tumor cell growth and cell cycle progression; Our results suggest that the open and unmethylated conformation of the miR-34a gene may be regulated by p53 able to bind the gene promoter;The miR-34 family under-expressed in-non small cell lung cancers NSCLCs are effectors of p53 activation upon irradiation of cells;MiR-34a a direct p53 target gene possesses tumor-suppressive properties as they mediate apoptosis cell cycle arrest and senescence;The miR-34 family is directly transactivated by tumor suppressor p53 which is frequently mutated in human epithelial ovarian cancer EOC; miR-34a expression is decreased in 100% and miR-34b*/c in 72% of EOC with p53 mutation whereas miR-34a is also downregulated in 93% of tumors with wild-type p53; Finally miR-34 reconstitution experiments in p53 mutant EOC cells resulted in reduced proliferation motility and invasion the latter of which was dependent on MET expression;miR-34a is transcriptionally induced by the tumor suppressor gene p53 which is often downregulated in non-small cell lung cancer NSCLC;In conclusion overexpression of PEBP4 reduced the sensitivity of A549 cells to DDP-induced cytotoxicity mainly through the altered expression of the p53 protein or the modulation of miR-34a;To investigate the effects of miR-449 and miR-34 on cell growth cell cycle and target gene expression based on these miRNA different expressions in ovarian cancer cell lines SKOV3 and SKOV3-ipl both with mutation of p53;Numerous studies have focused on the association between miR-34 family members which are direct p53 targets and carcinogenesis of many cancers including hepatocellular carcinoma HCC;p53 regulates nuclear GSK 3 levels through miR 34 mediated Axin2 suppression in colorectal cancer cells;MicroRNA-34a miR-34a a potential key effector of the p53 tumor-suppressor gene was studied as a potential tumor suppressor in uveal melanoma;The miR-34 family members are direct transcriptional targets of tumor suppressor p53 and loss of miR-34 function can impair p53-mediated cell cycle arrest and apoptosis;Profiling microRNA miRNA expression delineated TP53 alteration-associated miRNA profiles and identified miR-34a and miR-100 as the most significantly down- and upregulated miRNA respectively; Clinically low miR-34a expression and TP53 alterations predicted for chemotherapy resistance and inferior outcome; Thus detailed molecular profiling links impaired p53 to decreased miR-34a expression but also identifies p53-independent miR-34a induction mechanisms as shown in TP53biallelic altered cell lines treated with 15-deoxy-Δ1214-prostaglandin;MiR-34a a direct target of p53 has been shown to target several molecules associated with the cell cycle and cell survival pathways and its dysregulation is implicated in cancer drug resistance or sensitivity in several human cancers;MicroRNA-34a miR-34a is a direct transcriptional target of p53 and links tumor suppressor function and the oncogenic pathways in some cancers;Tumor suppressor p53 transcriptionally regulates expression of microRNA-34a which confers translational inhibition and mRNA degradation of genes involved in cell cycle control and apoptosis; MiR-34a expression was markedly reduced in p53-null PC3 cells and p53-mutated DU145 cells compared with LNCaP cells expressing wild-type p53;The microRNA encoding genes miR-34a and miR-34b/c represent direct p53 target genes and possess tumor suppressive properties as they mediate apoptosis cell cycle arrest and senescence; In the colorectal cancer samples a statistically significant correlation of miR-34a methylation and the absence of p53 mutation was detected; The mutual exclusiveness of miR-34a methylation and p53 mutation indicates that miR-34a inactivation may substitute for loss of p53 function in cancer ;;;;;poor survival;;;malignant trasformation;;;metastasis;;metastasis;;drug resistance;poor survival;;metastasis;;;;;;;metastasis;;;;;;;motility;;staging;tumorigenesis;;;;;drug resistance;poor survival;;immune resistance;;;progression;;;motility;;;;tumorigenesis;;;;drug resistance;poor survival;drug resistance;;; glioblastoma;glioblastoma;bladder cancer;breast cancer;lung squamous cell cancer;bladder cancer;esophageal cancer;lung squamous cell cancer;melanoma;retinoblastoma;breast cancer;colorectal cancer;colon cancer;colorectal cancer;lung cancer;breast cancer;lung squamous cell cancer;liver cancer;sarcoma;cervical and endocervical cancer;lung squamous cell cancer;lung squamous cell cancer;ovarian cancer;sarcoma;breast cancer;breast cancer;head and neck cancer;sarcoma;prostate cancer;kidney renal cell cancer;breast cancer;gastric cancer;prostate cancer;ovarian cancer;colon cancer;pancreatic cancer;esophageal cancer;lung cancer;pancreatic cancer;breast cancer;B cell lymphoma;cervical and endocervical cancer;colorectal cancer;prostate cancer;sarcoma;lung squamous cell cancer;esophageal cancer;ovarian cancer;lung squamous cell cancer;lung cancer;ovarian cancer;liver cancer;colorectal cancer;melanoma;liver cancer;acute myeloid leukemia;liver cancer;gastric cancer;prostate cancer;sarcoma hsa-miR-380-5p TP53 -0.356387125389103 0.0163515117264043 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate -0.130032370502874 2.53621800466177e-09 NA NA NA hsa-miR-381-3p TP53 -0.192118086401438 0.203198554750071 0.346312114104146 1.42081328137217e-05 MirTarget -0.10958470195975 2.36383687034549e-07 NA NA NA hsa-miR-421 TP53 -0.171573235029879 0.0518112933651029 0.346312114104146 1.42081328137217e-05 miRanda -0.12756767272718 0.000455424352559313 NA NA NA hsa-miR-491-5p TP53 -0.749881113074983 8.22859263179194e-09 0.346312114104146 1.42081328137217e-05 MirTarget;miRanda -0.210461133541589 1.59624493209635e-19 23519249 Targeted site prediction indicated that both Bcl-XL and TP53 contain miR-491-5p recognizing sites in their 3' UTRs; Overexpression of miR-491-5p in the pancreatic cancer cell line SW1990 effectively inhibited both endogenous Bcl-XL and TP53 gene expressions pancreatic cancer hsa-miR-504-5p TP53 -0.510726779625117 6.12122269907368e-05 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate;MirTarget -0.175599590135581 1.78517568542536e-12 25015107 TFF1 activates p53 through down regulation of miR 504 in gastric cancer; Alternatively we found that the reconstitution of TFF1 down-regulates miR-504 a negative regulator of p53; Western blot analysis data demonstrated that miR-504 abrogates TFF1-induced p53 protein expression and activity; In conclusion the in vitro and in vivo data demonstrate for the first time a novel mechanism by which the tumor suppressor functions of TFF1 involve activation of p53 through down-regulation of miR-504 gastric cancer hsa-miR-139-5p VANGL1 -0.647754756897633 2.15378307237163e-06 0.393332765138505 4.8929358405166e-07 miRanda -0.221487304140591 1.63219264969646e-19 NA NA NA hsa-miR-365a-3p VANGL1 -0.184222766207919 0.0292663235724171 0.393332765138505 4.8929358405166e-07 miRNAWalker2_validate -0.138007997840548 0.000734564534487376 NA NA NA hsa-miR-485-3p VANGL1 -0.530677478972593 0.00148549219838911 0.393332765138505 4.8929358405166e-07 mirMAP -0.110906513809924 2.18453031637113e-08 NA NA NA hsa-miR-582-3p VANGL1 -0.11807589183011 0.304077332003677 0.393332765138505 4.8929358405166e-07 mirMAP -0.193158474190292 6.60999525677353e-11 NA NA NA hsa-miR-582-5p VANGL1 -0.215764335500665 0.0760892640434509 0.393332765138505 4.8929358405166e-07 PITA;miRNATAP -0.166196098458238 8.96635918710152e-10 NA NA NA hsa-miR-767-5p VANGL1 -0.551653504513145 2.61109058244854e-05 0.393332765138505 4.8929358405166e-07 miRNATAP -0.149085716254215 6.86785697659207e-09 NA NA NA hsa-miR-9-3p VANGL1 -0.184945845984695 0.0290051908009009 0.393332765138505 4.8929358405166e-07 mirMAP -0.200261359828944 0.000209637057012779 NA NA NA hsa-miR-9-5p VANGL1 -0.125377971246422 0.269896477802284 0.393332765138505 4.8929358405166e-07 miRNATAP -0.425517379105293 5.82656022111352e-09 NA NA NA hsa-let-7d-5p VANGL2 0.111345229817909 0.0872634398336815 -0.0359057493022377 0.605188496685917 miRNATAP -0.499754581941064 4.37003349804556e-29 NA NA NA hsa-let-7e-5p VANGL2 0.0471189209570344 0.657255455444655 -0.0359057493022377 0.605188496685917 miRNATAP -0.187298561185776 3.45630174582343e-12 NA NA NA hsa-let-7f-5p VANGL2 0.0508269185845673 0.62677515045793 -0.0359057493022377 0.605188496685917 miRNATAP -0.114753681343738 0.000233826768042161 NA NA NA hsa-let-7g-3p VANGL2 0.00917503654783935 0.92786975338911 -0.0359057493022377 0.605188496685917 miRNATAP -0.118737730174105 2.20179373360798e-06 NA NA NA hsa-let-7g-5p VANGL2 -0.0253396334608382 0.742556489443668 -0.0359057493022377 0.605188496685917 miRNATAP -0.277589775522762 1.73736063621356e-11 NA NA NA hsa-let-7i-5p VANGL2 0.0952853587923244 0.192120688957249 -0.0359057493022377 0.605188496685917 miRNATAP -0.118260321069352 0.00614061543561553 NA NA NA hsa-miR-106a-5p VANGL2 0.110074064773897 0.13045815990621 -0.0359057493022377 0.605188496685917 mirMAP -0.26207350973845 1.00949932027566e-13 NA NA NA hsa-miR-107 VANGL2 -0.121070851008387 0.198381281894242 -0.0359057493022377 0.605188496685917 miRanda -0.279069657878178 7.64070884234208e-26 NA NA NA hsa-miR-125a-5p VANGL2 -0.0833349424517387 0.325440200253607 -0.0359057493022377 0.605188496685917 PITA;mirMAP -0.237895298599963 1.78232537097135e-11 NA NA NA hsa-miR-128-3p VANGL2 -0.781932174412672 7.1812756321342e-10 -0.0359057493022377 0.605188496685917 MirTarget -0.115710974894351 3.22374281445121e-08 NA NA NA hsa-miR-139-5p VANGL2 -0.647754756897633 2.15378307237163e-06 -0.0359057493022377 0.605188496685917 miRanda -0.165175847058755 3.53881829823352e-20 NA NA NA hsa-miR-140-3p VANGL2 -0.123864258867705 0.14796686619449 -0.0359057493022377 0.605188496685917 PITA;miRNATAP -0.258254888955175 6.1525832995835e-12 NA NA NA hsa-miR-143-3p VANGL2 0.289829963197683 0.0420892105534401 -0.0359057493022377 0.605188496685917 mirMAP -0.149758659768074 5.27791817345817e-15 NA NA NA hsa-miR-146b-3p VANGL2 0.283486177568242 0.0118918188864879 -0.0359057493022377 0.605188496685917 PITA -0.252942167074745 1.47277890162343e-33 NA NA NA hsa-miR-15b-3p VANGL2 0.690804403863844 8.48784755123775e-09 -0.0359057493022377 0.605188496685917 mirMAP -0.138723425485393 2.78475633051045e-12 NA NA NA hsa-miR-185-5p VANGL2 -0.0767432095218297 0.404113540276816 -0.0359057493022377 0.605188496685917 MirTarget -0.227732913871817 1.73626037502158e-16 NA NA NA hsa-miR-186-5p VANGL2 0.0606381894130505 0.514217717592464 -0.0359057493022377 0.605188496685917 mirMAP -0.135757187547072 3.22568932245191e-06 NA NA NA hsa-miR-20b-5p VANGL2 0.144541062989476 0.0992042333556543 -0.0359057493022377 0.605188496685917 mirMAP -0.182713896358135 1.12236043548289e-09 NA NA NA hsa-miR-24-3p VANGL2 0.133257261462871 0.212960921400853 -0.0359057493022377 0.605188496685917 MirTarget -0.184540476590466 2.04305614927047e-13 NA NA NA hsa-miR-26a-5p VANGL2 0.033823776747294 0.726610414342369 -0.0359057493022377 0.605188496685917 MirTarget -0.182755494813056 2.40574421960339e-09 NA NA NA hsa-miR-26b-5p VANGL2 -0.0984536538762768 0.231803769574623 -0.0359057493022377 0.605188496685917 miRNAWalker2_validate;MirTarget -0.148111656579076 3.58294797019281e-05 NA NA NA hsa-miR-27b-3p VANGL2 -0.0599187745243146 0.58208143475992 -0.0359057493022377 0.605188496685917 miRNATAP -0.175704900790756 9.42465281746495e-13 NA NA NA hsa-miR-30a-5p VANGL2 -0.062942936611238 0.513851954700252 -0.0359057493022377 0.605188496685917 mirMAP -0.175379477728483 3.28680429137561e-05 NA NA NA hsa-miR-30b-5p VANGL2 -0.0858101016322106 0.263243418521854 -0.0359057493022377 0.605188496685917 mirMAP -0.274513419553911 5.87435371811175e-13 NA NA NA hsa-miR-30c-5p VANGL2 -0.0469114469943097 0.565934557464627 -0.0359057493022377 0.605188496685917 mirMAP -0.212218063448294 4.02414819503596e-08 NA NA NA hsa-miR-30d-5p VANGL2 -0.0607010868720046 0.471410043548794 -0.0359057493022377 0.605188496685917 mirMAP -0.219813722798304 6.53414505198554e-07 NA NA NA hsa-miR-30e-5p VANGL2 0.0764521828640934 0.41904991629622 -0.0359057493022377 0.605188496685917 mirMAP -0.168936256140441 4.00048320269343e-06 NA NA NA hsa-miR-323b-3p VANGL2 -0.254474308066903 0.15651329633719 -0.0359057493022377 0.605188496685917 mirMAP -0.124495995890213 5.97528884964503e-21 NA NA NA hsa-miR-335-5p VANGL2 0.0938511632756978 0.336889056387694 -0.0359057493022377 0.605188496685917 miRNAWalker2_validate -0.103239266085002 5.95758231763514e-05 NA NA NA hsa-miR-33a-3p VANGL2 -0.158366376619191 0.0991512910387226 -0.0359057493022377 0.605188496685917 miRNATAP -0.133717361270953 1.84676669718063e-07 NA NA NA hsa-miR-378a-5p VANGL2 0.0868099877034774 0.389811538663121 -0.0359057493022377 0.605188496685917 MirTarget -0.247249246342788 1.73109590282775e-25 NA NA NA hsa-miR-409-3p VANGL2 0.00456692516634361 0.974143243758506 -0.0359057493022377 0.605188496685917 miRNATAP -0.204494285170165 1.00895845381566e-35 NA NA NA hsa-miR-485-3p VANGL2 -0.530677478972593 0.00148549219838911 -0.0359057493022377 0.605188496685917 mirMAP -0.152163530262258 1.06388272867884e-27 NA NA NA hsa-miR-495-3p VANGL2 -0.421982588962504 0.00504424038526901 -0.0359057493022377 0.605188496685917 mirMAP -0.187744698785243 3.71703218577001e-34 NA NA NA hsa-miR-501-5p VANGL2 0.0878951859817452 0.309663377222443 -0.0359057493022377 0.605188496685917 mirMAP -0.123494087959052 1.55768933058534e-05 NA NA NA hsa-miR-539-5p VANGL2 -0.326485413953598 0.0554453076411246 -0.0359057493022377 0.605188496685917 mirMAP -0.155535725892325 3.96726337452827e-30 NA NA NA hsa-miR-582-3p VANGL2 -0.11807589183011 0.304077332003677 -0.0359057493022377 0.605188496685917 mirMAP -0.256266584654552 1.56354016562525e-35 NA NA NA hsa-miR-582-5p VANGL2 -0.215764335500665 0.0760892640434509 -0.0359057493022377 0.605188496685917 PITA;miRNATAP -0.218658994096592 1.57998010484502e-30 NA NA NA hsa-miR-589-5p VANGL2 -0.0382528919634639 0.5844074434222 -0.0359057493022377 0.605188496685917 mirMAP -0.129349826944564 0.00166819986499161 NA NA NA hsa-miR-590-3p VANGL2 0.312951515438396 0.000480455423843996 -0.0359057493022377 0.605188496685917 miRanda -0.133897217330847 9.82732081037102e-07 NA NA NA hsa-miR-7-1-3p VANGL2 -0.0894475316162393 0.37322359785108 -0.0359057493022377 0.605188496685917 mirMAP -0.271680414506901 3.29072043223058e-31 NA NA NA hsa-miR-940 VANGL2 -0.0183807673806575 0.881747775878136 -0.0359057493022377 0.605188496685917 PITA;miRNATAP -0.169868231638032 1.47547997711848e-18 NA NA NA hsa-miR-320a WIF1 0.092135599636725 0.243028758989929 -0.973720854078464 0.00121740144674922 miRanda -0.790918816336441 0.000162475122964334 NA NA NA hsa-miR-320a WNT10B 0.092135599636725 0.243028758989929 -0.592908726076304 0.00261232446039008 miRanda -0.579593394103102 2.30772443901546e-05 NA NA NA hsa-miR-320b WNT10B 0.283477746304177 0.0005953763020907 -0.592908726076304 0.00261232446039008 miRanda -0.363931506705679 0.000500196920355503 NA NA NA hsa-miR-320c WNT10B 0.343259124189966 0.000248338401291051 -0.592908726076304 0.00261232446039008 miRanda -0.506024692638196 7.50377169165381e-08 NA NA NA hsa-miR-126-5p WNT3 0.177332403948664 0.0711675116243123 -0.309929888188502 1.17656991996691e-05 MirTarget -0.174369633593318 1.00872309355584e-07 NA NA NA hsa-miR-1301-3p WNT3 -0.105695714210758 0.152249184194132 -0.309929888188502 1.17656991996691e-05 miRNAWalker2_validate -0.114004766778928 0.00921972502155149 NA NA NA hsa-miR-146a-5p WNT3 0.148942451196282 0.114229072828724 -0.309929888188502 1.17656991996691e-05 MirTarget -0.206920765228713 2.8454487886984e-10 NA NA NA hsa-miR-146b-5p WNT3 0.441078059667297 0.000237619929889385 -0.309929888188502 1.17656991996691e-05 MirTarget;PITA;miRanda;miRNATAP -0.242814529002202 1.17336382735274e-20 NA NA NA hsa-miR-148b-5p WNT3 0.127111784487801 0.188731110216917 -0.309929888188502 1.17656991996691e-05 mirMAP -0.200103300112034 4.34461173494392e-10 NA NA NA hsa-miR-19a-3p WNT3 0.0466707843731911 0.576818938277755 -0.309929888188502 1.17656991996691e-05 MirTarget;miRNATAP -0.133156065168973 0.000600755834130786 NA NA NA hsa-miR-19b-3p WNT3 -0.0138427450847924 0.856506310673067 -0.309929888188502 1.17656991996691e-05 MirTarget;miRNATAP -0.186525616851386 5.31122852886452e-05 NA NA NA hsa-miR-215-5p WNT3 0.545674318352698 2.35150596237453e-05 -0.309929888188502 1.17656991996691e-05 miRNAWalker2_validate -0.101853003365689 3.07309323374689e-05 NA NA NA hsa-miR-361-5p WNT3 0.0107519600643302 0.882230614095565 -0.309929888188502 1.17656991996691e-05 MirTarget;PITA;miRanda;miRNATAP -0.247188999398098 2.79378886728125e-06 NA NA NA hsa-miR-362-3p WNT3 0.032375035235532 0.736465332563774 -0.309929888188502 1.17656991996691e-05 PITA;miRanda;miRNATAP -0.154309304703628 1.50748997836284e-06 NA NA NA hsa-miR-374a-3p WNT3 0.176226170437625 0.0343958848425446 -0.309929888188502 1.17656991996691e-05 MirTarget -0.191351205727516 3.55403056353316e-05 NA NA NA hsa-miR-374a-5p WNT3 0.0121037060909277 0.865417963345881 -0.309929888188502 1.17656991996691e-05 MirTarget -0.138046556143134 0.00322357743945585 NA NA NA hsa-miR-576-5p WNT3 0.106482276040047 0.194379152564166 -0.309929888188502 1.17656991996691e-05 mirMAP -0.2380802588046 2.8693747699609e-10 NA NA NA hsa-miR-589-3p WNT3 0.00739371736361305 0.927768051649329 -0.309929888188502 1.17656991996691e-05 mirMAP -0.112347930164554 0.00345092064510247 NA NA NA hsa-miR-671-5p WNT3 0.379677704170736 0.000129391032677459 -0.309929888188502 1.17656991996691e-05 MirTarget -0.242655520280922 8.34868492925196e-16 NA NA NA hsa-miR-126-5p WNT5A 0.177332403948664 0.0711675116243123 0.401727178109578 0.000135878679478885 mirMAP -0.197498035605205 2.92702569263705e-05 NA NA NA hsa-miR-127-5p WNT5A -0.128719168376827 0.401210814502785 0.401727178109578 0.000135878679478885 PITA;miRNATAP -0.148503710600712 5.58056138975753e-07 NA NA NA hsa-miR-129-5p WNT5A -0.567133990117126 0.00116152215679936 0.401727178109578 0.000135878679478885 PITA;miRanda;miRNATAP -0.122949419919608 1.9178703847978e-06 NA NA NA hsa-miR-140-3p WNT5A -0.123864258867705 0.14796686619449 0.401727178109578 0.000135878679478885 MirTarget;miRNATAP -0.304640564073949 8.7015213884132e-06 NA NA NA hsa-miR-154-5p WNT5A -0.226468848904462 0.107380908211261 0.401727178109578 0.000135878679478885 mirMAP;miRNATAP -0.133746849078689 2.20811690518715e-05 NA NA NA hsa-miR-182-5p WNT5A -0.146726537592027 0.389265298808118 0.401727178109578 0.000135878679478885 MirTarget -0.17706315884905 4.76584976388537e-11 NA NA NA hsa-miR-326 WNT5A -0.631050656251074 8.83643450601471e-05 0.401727178109578 0.000135878679478885 miRanda -0.121863379344651 7.54927535246161e-06 NA NA NA hsa-miR-330-5p WNT5A -0.262932095995605 0.0465226565966658 0.401727178109578 0.000135878679478885 miRanda -0.182269668340434 4.68881013813934e-08 NA NA NA hsa-miR-3607-3p WNT5A -0.0118040987013632 0.907228689257085 0.401727178109578 0.000135878679478885 mirMAP -0.158859120300375 0.00033593635970035 NA NA NA hsa-miR-369-3p WNT5A -0.153496605399658 0.296055925448078 0.401727178109578 0.000135878679478885 miRNATAP -0.109058905963049 0.000320216606169546 NA NA NA hsa-miR-409-3p WNT5A 0.00456692516634361 0.974143243758506 0.401727178109578 0.000135878679478885 mirMAP -0.110008292104967 0.000487794597719254 NA NA NA hsa-miR-491-3p WNT5A -0.523374665885358 1.93479565404951e-05 0.401727178109578 0.000135878679478885 mirMAP -0.148527988707063 3.61608334059833e-05 NA NA NA hsa-miR-539-5p WNT5A -0.326485413953598 0.0554453076411246 0.401727178109578 0.000135878679478885 mirMAP -0.161017969407705 3.21999166239326e-10 NA NA NA hsa-miR-582-5p WNT5A -0.215764335500665 0.0760892640434509 0.401727178109578 0.000135878679478885 miRNATAP -0.328837370224082 5.30150255364318e-21 NA NA NA hsa-miR-7-1-3p WNT5A -0.0894475316162393 0.37322359785108 0.401727178109578 0.000135878679478885 mirMAP -0.23358023082722 1.29867246418668e-07 NA NA NA hsa-miR-767-5p WNT5A -0.551653504513145 2.61109058244854e-05 0.401727178109578 0.000135878679478885 PITA;miRNATAP -0.21156019312404 4.27965570737888e-10 NA NA NA hsa-miR-885-5p WNT5A -0.423614695846868 1.14213289528402e-05 0.401727178109578 0.000135878679478885 MirTarget;PITA -0.286582466253295 6.75804778438008e-10 NA NA NA hsa-miR-9-5p WNT6 -0.125377971246422 0.269896477802284 0.438305948269952 0.000160590816729552 miRNAWalker2_validate -0.293232476596186 0.00869219444847102 NA NA NA hsa-miR-15a-5p WNT7A 0.142658985373611 0.0536219185009004 -0.427111937724664 0.000609167282421501 MirTarget -0.302514162115996 0.000721878677507473 NA NA NA hsa-miR-15b-5p WNT7A 0.592863156692837 1.41971517354055e-10 -0.427111937724664 0.000609167282421501 MirTarget -0.262266101310129 2.2483257995866e-05 27195958 WNT7A Regulation by miR 15b in Ovarian Cancer; In the present study we report that WNT7A is a direct target of miR-15b in ovarian cancer; We showed that a luciferase reporter containing the putative binding site of miR-15b in the WNT7A 3'-UTR was significantly repressed by miR-15b; Mutation of the putative binding site of miR-15b in the WNT7A 3'-UTR restored luciferase activity; Furthermore miR-15b was able to repress increased levels of TOPFLASH activity by WNT7A but not those induced by S33Y; Additionally miR-15b dose-dependently decreased WNT7A expression; When we evaluated the prognostic impact of WNT7A and miR-15b expression using TCGA datasets a significant inverse correlation in which high-expression of WNT7A and low-expression of miR-15b was associated with reduced survival rates of ovarian cancer patients; These results suggest that WNT7A is post-transcriptionally regulated by miR-15b which could be down-regulated by promoter hypermethylation potentially via DNMT1 in ovarian cancer poor survival ovarian cancer hsa-miR-16-5p WNT7A 0.246024668671282 0.00346042804503716 -0.427111937724664 0.000609167282421501 MirTarget -0.297241450931029 0.000104364357316878 NA NA NA hsa-miR-3065-5p WNT7A -0.262608140481507 0.0414570974148034 -0.427111937724664 0.000609167282421501 mirMAP -0.132174618677981 0.00190951741985067 NA NA NA hsa-miR-374a-3p WNT7A 0.176226170437625 0.0343958848425446 -0.427111937724664 0.000609167282421501 MirTarget -0.505943339864985 3.89373680861855e-10 NA NA NA hsa-miR-3913-5p WNT7A 0.276883251911602 0.00186113779811511 -0.427111937724664 0.000609167282421501 mirMAP -0.345868894391628 1.29286851121382e-08 NA NA NA hsa-miR-424-5p WNT7A 0.25140374049676 0.00709934939774983 -0.427111937724664 0.000609167282421501 MirTarget -0.194909899316808 0.00146972480587374 NA NA NA hsa-miR-590-3p WNT7A 0.312951515438396 0.000480455423843996 -0.427111937724664 0.000609167282421501 miRanda -0.358425076665779 2.64327874280996e-09 NA NA NA hsa-miR-106b-5p WNT7B 0.167096183547615 0.0497544396383451 -0.918830041961131 3.77517210098989e-07 mirMAP -0.506885417748126 1.32365569542327e-06 NA NA NA hsa-miR-10a-5p WNT7B 1.10332501906319 5.3831631561183e-08 -0.918830041961131 3.77517210098989e-07 mirMAP -0.359302972713279 4.05507969998456e-22 NA NA NA hsa-miR-10b-5p WNT7B 1.54586540986745 2.64595843546465e-08 -0.918830041961131 3.77517210098989e-07 mirMAP -0.139168120977542 8.52477478967833e-07 NA NA NA hsa-miR-1226-3p WNT7B -0.098618802853881 0.346683714981524 -0.918830041961131 3.77517210098989e-07 mirMAP -0.523641271989431 2.02706679849717e-12 NA NA NA hsa-miR-149-5p WNT7B -0.0535821592029952 0.657713892012548 -0.918830041961131 3.77517210098989e-07 mirMAP -0.229135194771077 0.000609962251335446 NA NA NA hsa-miR-199a-5p WNT7B 0.174889610847968 0.0900027418912454 -0.918830041961131 3.77517210098989e-07 miRanda;miRNATAP -0.270900402870767 0.000494454398849817 NA NA NA hsa-miR-199b-5p WNT7B 0.436298593972862 0.00200225454383871 -0.918830041961131 3.77517210098989e-07 miRanda;miRNATAP -0.353386738832987 1.24404529725684e-10 NA NA NA hsa-miR-24-3p WNT7B 0.133257261462871 0.212960921400853 -0.918830041961131 3.77517210098989e-07 mirMAP -0.659473787718644 1.71220984196383e-16 NA NA NA hsa-miR-296-5p WNT7B -0.0192165981442809 0.870822664524408 -0.918830041961131 3.77517210098989e-07 MirTarget;miRNATAP -0.318175253687426 1.90749505435342e-06 NA NA NA hsa-miR-30a-5p WNT7B -0.062942936611238 0.513851954700252 -0.918830041961131 3.77517210098989e-07 miRNATAP -1.09963803283229 8.67989045414658e-17 NA NA NA hsa-miR-30c-5p WNT7B -0.0469114469943097 0.565934557464627 -0.918830041961131 3.77517210098989e-07 miRNATAP -0.962233685285233 3.25761316479734e-15 NA NA NA hsa-miR-331-3p WNT7B 0.0126984726684189 0.905175053956974 -0.918830041961131 3.77517210098989e-07 mirMAP -0.272848103574899 0.00028542137228072 NA NA NA hsa-miR-34a-5p WNT7B 0.143472919835524 0.211283228567057 -0.918830041961131 3.77517210098989e-07 mirMAP -0.57535220339094 6.07927296391889e-17 NA NA NA hsa-miR-34c-5p WNT7B 0.181931113688093 0.257266965617363 -0.918830041961131 3.77517210098989e-07 mirMAP -0.220337265594989 5.76042798885719e-06 NA NA NA hsa-miR-505-3p WNT7B 0.115486008167472 0.109833720698312 -0.918830041961131 3.77517210098989e-07 miRNATAP -0.717613701322711 3.52607407733017e-10 NA NA NA hsa-miR-625-5p WNT7B -0.0264137834407145 0.802098211251158 -0.918830041961131 3.77517210098989e-07 mirMAP -0.251076445542322 0.000879882648590086 NA NA NA hsa-miR-664a-5p WNT7B 0.0825994937558296 0.264421724444089 -0.918830041961131 3.77517210098989e-07 MirTarget -0.366174471226252 0.000650900354168328 NA NA NA hsa-miR-1226-3p WNT9A -0.098618802853881 0.346683714981524 0.137227170443756 0.352868874075173 mirMAP -0.325837101305464 9.51310232305054e-08 NA NA NA hsa-miR-1271-5p WNT9A 0.101224150198862 0.215169362708611 0.137227170443756 0.352868874075173 mirMAP -0.224936015797023 0.00503150895427495 NA NA NA hsa-miR-148a-3p WNT9A 0.306821592493439 0.0392356958885949 0.137227170443756 0.352868874075173 mirMAP -0.196920963605196 1.41392486082418e-05 NA NA NA hsa-miR-193a-3p WNT9A 0.395602305834739 0.00182611787714301 0.137227170443756 0.352868874075173 mirMAP -0.151995273360832 0.00330029714433925 NA NA NA hsa-miR-589-3p WNT9A 0.00739371736361305 0.927768051649329 0.137227170443756 0.352868874075173 mirMAP -0.384061717193507 1.24427808512787e-06 NA NA NA hsa-miR-708-5p WNT9A -0.00936519718301376 0.919857671524527 0.137227170443756 0.352868874075173 mirMAP -0.53397673410074 5.30249659386835e-13 NA NA NA