miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-139-5p AKT3 -1.46099200329485 7.85040381494472e-22 0.757395805826156 5.24354425444781e-05 PITA;miRanda -0.204988506808972 7.26517518198736e-05 NA NA NA hsa-miR-15a-5p AKT3 0.783550182002274 2.60699595655907e-11 0.757395805826156 5.24354425444781e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265716982670402 0.000109391971495535 NA NA NA hsa-miR-17-5p AKT3 1.41924888736771 2.75805544953758e-18 0.757395805826156 5.24354425444781e-05 TargetScan;miRNATAP -0.210478431167346 1.46778910374435e-05 NA NA NA hsa-miR-205-3p AKT3 1.2960640797621 5.80786479909147e-11 0.757395805826156 5.24354425444781e-05 mirMAP -0.248708307357298 5.71786142986847e-10 NA NA NA hsa-miR-20a-5p AKT3 1.1531986665452 1.02385132917958e-11 0.757395805826156 5.24354425444781e-05 miRNATAP -0.244010493055021 2.19437052623105e-07 NA NA NA hsa-miR-29b-3p AKT3 -0.110721443686039 0.511264554091106 0.757395805826156 5.24354425444781e-05 miRNATAP -0.255169036216248 1.32894370465011e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-362-3p AKT3 -0.697212068252854 2.61718493418184e-06 0.757395805826156 5.24354425444781e-05 miRanda -0.198442787422331 0.000314248564221821 NA NA NA hsa-miR-362-5p AKT3 0.41089772861323 0.0404254902071382 0.757395805826156 5.24354425444781e-05 PITA;TargetScan;miRNATAP -0.156881795440952 0.000120211641903581 NA NA NA hsa-miR-429 ANGPT1 0.559451508722375 0.00563641638673083 -0.994659806908684 0.000102297444730898 miRanda -0.2797916675188 3.51642052342136e-07 NA NA NA hsa-miR-590-3p ANGPT1 0.221436901462551 0.0965904764063157 -0.994659806908684 0.000102297444730898 PITA;miRanda;mirMAP -0.260652523349808 0.00203849703312725 NA NA NA hsa-miR-944 ANGPT1 1.47323925060177 2.61626403984929e-13 -0.994659806908684 0.000102297444730898 PITA;mirMAP -0.323166948397416 1.72218448279528e-09 NA NA NA hsa-miR-148a-5p ANGPT2 -1.00478606532747 1.38045244999229e-07 1.60682659917739 3.22512104906665e-21 mirMAP -0.111398410451088 0.00531513825463852 NA NA NA hsa-miR-19b-3p ANGPT2 0.538732279378089 0.000622008277870679 1.60682659917739 3.22512104906665e-21 MirTarget -0.142908635743858 0.00344056723294101 NA NA NA hsa-miR-374a-5p ANGPT2 -0.621903385111545 6.61791773205282e-12 1.60682659917739 3.22512104906665e-21 mirMAP -0.411120960907931 9.09637924296375e-07 NA NA NA hsa-miR-374b-5p ANGPT2 -0.288413933608091 0.0041474558664058 1.60682659917739 3.22512104906665e-21 mirMAP -0.368289519242387 1.53606293531056e-06 NA NA NA hsa-miR-429 ANGPT2 0.559451508722375 0.00563641638673083 1.60682659917739 3.22512104906665e-21 miRanda -0.188271200316882 6.15570379949398e-07 NA NA NA hsa-miR-582-5p ANGPT2 -0.0366995972742474 0.821827119138923 1.60682659917739 3.22512104906665e-21 mirMAP -0.168812520671104 0.000363324472297187 NA NA NA hsa-miR-664a-3p ANGPT2 -0.256108763664991 0.0513188660751664 1.60682659917739 3.22512104906665e-21 mirMAP -0.314343374722018 6.99960306928084e-08 NA NA NA hsa-let-7a-3p ATF2 0.0966652362351867 0.423761916840503 0.104371396863857 0.473734669024994 MirTarget;mirMAP;miRNATAP -0.203264433681785 0.000111795870563359 NA NA NA hsa-miR-10b-5p ATF2 -0.582989331935508 4.56688330655626e-06 0.104371396863857 0.473734669024994 MirTarget;miRNATAP -0.273722697904369 2.44697310743771e-08 NA NA NA hsa-miR-15a-5p ATF2 0.783550182002274 2.60699595655907e-11 0.104371396863857 0.473734669024994 miRNAWalker2_validate -0.445586009471093 5.23484994441582e-18 NA NA NA hsa-miR-181a-5p ATF2 0.819060835827404 1.38616688310277e-13 0.104371396863857 0.473734669024994 mirMAP;miRNATAP -0.20096756561152 0.000341029724542025 NA NA NA hsa-miR-181b-5p ATF2 0.974255518824355 2.64876280203475e-16 0.104371396863857 0.473734669024994 mirMAP;miRNATAP -0.143240188988564 0.00584341108166169 NA NA NA hsa-miR-19a-3p ATF2 1.35800152353624 2.80940447111944e-12 0.104371396863857 0.473734669024994 MirTarget;miRNATAP -0.265805757469969 8.34429353177816e-18 NA NA NA hsa-miR-19b-3p ATF2 0.538732279378089 0.000622008277870679 0.104371396863857 0.473734669024994 miRNAWalker2_validate;MirTarget;miRNATAP -0.362231701788782 7.48771210013745e-21 NA NA NA hsa-miR-222-3p ATF2 1.08197052578759 2.32604040301699e-14 0.104371396863857 0.473734669024994 MirTarget -0.176026243848901 5.18693517108327e-05 NA NA NA hsa-miR-26b-5p ATF2 -0.254478038884324 0.0285227763044636 0.104371396863857 0.473734669024994 MirTarget;miRNATAP -0.38217827412852 1.1347354511156e-12 21901137 Coordinated regulation of ATF2 by miR 26b in γ irradiated lung cancer cells; Concurrent analysis of time-series mRNA and microRNA profiles uncovered that expression of miR-26b was down regulated and its target activating transcription factor 2 ATF2 mRNA was up regulated in γ-irradiated H1299 cells; IR in miR-26b overexpressed H1299 cells could not induce expression of ATF2; From these results we concluded that IR-induced up-regulation of ATF2 was coordinately enhanced by suppression of miR-26b in lung cancer cells which may enhance the effect of IR in the MAPK signaling pathway lung cancer hsa-miR-29a-5p ATF2 0.323252792625584 0.0370417231222825 0.104371396863857 0.473734669024994 MirTarget;miRNATAP -0.216551920000306 9.1806205494168e-08 NA NA NA hsa-miR-30a-5p ATF2 -1.79779915425811 1.93360169837799e-26 0.104371396863857 0.473734669024994 mirMAP -0.119397648903742 0.000797054500428221 NA NA NA hsa-miR-30b-5p ATF2 -0.400238605368173 0.00346540992719245 0.104371396863857 0.473734669024994 mirMAP -0.323789672145047 9.74767489864219e-13 NA NA NA hsa-miR-30c-5p ATF2 0.021222006155897 0.886366656528128 0.104371396863857 0.473734669024994 mirMAP -0.357138874601189 7.87667906491707e-18 NA NA NA hsa-miR-320a ATF2 0.801356001806321 4.91397101474502e-09 0.104371396863857 0.473734669024994 miRanda -0.153624053512537 0.000767519462097854 NA NA NA hsa-miR-338-3p ATF2 -0.948755228846395 8.99167125682392e-08 0.104371396863857 0.473734669024994 miRanda -0.309897140896372 9.53284637253794e-20 NA NA NA hsa-miR-3607-3p ATF2 1.01377165357363 9.13355519701165e-05 0.104371396863857 0.473734669024994 mirMAP -0.126287135739983 1.5652976223426e-07 NA NA NA hsa-miR-374b-5p ATF2 -0.288413933608091 0.0041474558664058 0.104371396863857 0.473734669024994 miRNAWalker2_validate;mirMAP;miRNATAP -0.238849509375957 0.000158559195775339 NA NA NA hsa-miR-582-5p ATF2 -0.0366995972742474 0.821827119138923 0.104371396863857 0.473734669024994 MirTarget;miRNATAP -0.16855808035157 1.39388138974067e-05 NA NA NA hsa-miR-590-3p ATF2 0.221436901462551 0.0965904764063157 0.104371396863857 0.473734669024994 MirTarget;miRanda;mirMAP;miRNATAP -0.123694465854944 0.00961729064449703 NA NA NA hsa-miR-127-3p BAD -1.47175957435172 9.8707469067377e-14 0.232698220027489 0.0410974615650229 miRanda;miRNATAP -0.109748766939369 6.41360405115286e-06 NA NA NA hsa-miR-326 BAD -0.425943992128769 0.0415010315530797 0.232698220027489 0.0410974615650229 miRanda -0.161061952496571 5.50625637973764e-12 NA NA NA hsa-miR-17-5p BCL2 1.41924888736771 2.75805544953758e-18 -0.910322309161486 1.41820798645135e-05 miRNAWalker2_validate;miRTarBase -0.286055141796067 1.32806406578446e-07 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-181b-5p BCL2 0.974255518824355 2.64876280203475e-16 -0.910322309161486 1.41820798645135e-05 miRNAWalker2_validate;miRTarBase -0.373058996674441 6.31834441315239e-07 25524579 Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression lung squamous cell cancer hsa-miR-205-3p BCL2 1.2960640797621 5.80786479909147e-11 -0.910322309161486 1.41820798645135e-05 mirMAP -0.227937256601493 4.79177139227398e-07 23612742 MicroRNA 205 a novel regulator of the anti apoptotic protein Bcl2 is downregulated in prostate cancer; In addition we describe the anti-apoptotic protein BCL2 as a target of miR-205 relevant for prostate cancer due to its role in prognosis of primary tumours and in the appearance of androgen independence; The repression of BCL2 by miR-205 was confirmed using reporter assays and western blotting; Consistent with its anti-apoptotic target BCL2 miR-205 promoted apoptosis in prostate cancer cells in response to DNA damage by cisplatin and doxorubicin in the prostate cancer cell lines PC3 and LnCap worse prognosis;drug resistance prostate cancer hsa-miR-20a-3p BCL2 1.34885093664027 2.07697464119202e-12 -0.910322309161486 1.41820798645135e-05 mirMAP -0.210143759838025 6.72382138476575e-06 NA NA NA hsa-miR-20a-5p BCL2 1.1531986665452 1.02385132917958e-11 -0.910322309161486 1.41820798645135e-05 miRNAWalker2_validate;miRTarBase -0.210135069736519 7.53662123683259e-05 NA NA NA hsa-miR-21-5p BCL2 1.62465922021121 3.44191300985109e-58 -0.910322309161486 1.41820798645135e-05 miRNAWalker2_validate;miRTarBase -0.44340837518524 4.13326577253647e-08 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-224-3p BCL2 0.502645536188015 0.0081142387260641 -0.910322309161486 1.41820798645135e-05 mirMAP -0.149838612967231 0.00210796622480369 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-224-5p BCL2 1.94534596857416 1.88348779207332e-19 -0.910322309161486 1.41820798645135e-05 mirMAP -0.353815516939307 5.70417527374627e-19 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-24-2-5p BCL2 1.27293931700635 4.48240091510596e-15 -0.910322309161486 1.41820798645135e-05 miRNAWalker2_validate;miRTarBase -0.493507075193325 1.92280534065188e-20 NA NA NA hsa-miR-29a-5p BCL2 0.323252792625584 0.0370417231222825 -0.910322309161486 1.41820798645135e-05 mirMAP -0.155079084813299 0.00916942782727535 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-365a-3p BCL2 0.446833934952926 0.00233857759218299 -0.910322309161486 1.41820798645135e-05 miRNAWalker2_validate;miRTarBase -0.618758400072067 4.65430504458955e-25 NA NA NA hsa-miR-450b-5p BCL2 1.25529820885833 1.18847120528666e-15 -0.910322309161486 1.41820798645135e-05 mirMAP -0.302976225522567 8.63706453164136e-08 NA NA NA hsa-miR-452-5p BCL2 0.373288744398455 0.0348485937209964 -0.910322309161486 1.41820798645135e-05 mirMAP -0.294458928135025 1.04088708041247e-08 NA NA NA hsa-miR-455-5p BCL2 1.408595672323 5.52039116456697e-22 -0.910322309161486 1.41820798645135e-05 mirMAP -0.672065921862735 3.74015168127993e-32 NA NA NA hsa-miR-542-3p BCL2 0.643308814904977 8.81635403230104e-07 -0.910322309161486 1.41820798645135e-05 mirMAP -0.295630720394228 2.17157389286201e-05 NA NA NA hsa-miR-590-5p BCL2 0.763025362395968 3.65305892505623e-09 -0.910322309161486 1.41820798645135e-05 miRanda -0.212747360248047 0.00250525422232118 NA NA NA hsa-miR-7-5p BCL2 1.55674721532755 2.41989824363914e-11 -0.910322309161486 1.41820798645135e-05 miRNAWalker2_validate;miRTarBase;mirMAP -0.241358237325723 1.79388200062243e-09 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-miR-369-3p BCL2L11 -1.2344419076994 2.66882944171146e-10 0.430059152882317 2.11829661342833e-05 mirMAP -0.127309368658961 8.08113305889039e-09 NA NA NA hsa-miR-495-3p BCL2L11 -1.47803501311999 6.88839745293927e-13 0.430059152882317 2.11829661342833e-05 mirMAP -0.12819693249489 7.03321810523906e-10 26375442 Combination of miR-130a and miR-495 significantly decreased apoptosis determined by Annexin V-FITC/propidium iodide staining and flow cytometric analysis and the expression of Bim in SNU484 gastric cancer cells; In addition p21 and Bim RUNX3 target genes were completely downregulated by the combination of miR-130a and miR-495 gastric cancer hsa-let-7b-3p BDNF 0.120166961637302 0.299224004314356 0.0408778714112631 0.883450816679916 MirTarget;miRNATAP -0.485153955582307 3.78595524866656e-06 NA NA NA hsa-miR-142-5p BDNF 0.288897753038094 0.0900009317815725 0.0408778714112631 0.883450816679916 mirMAP -0.308543354723933 1.36682819592341e-05 NA NA NA hsa-miR-146b-5p BDNF 0.917975986853978 3.33749259316025e-09 0.0408778714112631 0.883450816679916 miRanda -0.295426001779662 0.000122805573761243 NA NA NA hsa-miR-155-5p BDNF 0.533437622040649 0.00248671179205372 0.0408778714112631 0.883450816679916 miRNATAP -0.22678558150571 0.000944767256917019 NA NA NA hsa-miR-22-3p BDNF 0.00776313533473072 0.926356548861307 0.0408778714112631 0.883450816679916 miRNAWalker2_validate;miRTarBase -0.427506450899018 0.00361347435585047 NA NA NA hsa-miR-29b-1-5p BDNF 1.39669186711325 4.36960953138935e-11 0.0408778714112631 0.883450816679916 mirMAP -0.226952768941406 5.14949172622145e-05 NA NA NA hsa-miR-338-5p BDNF -1.71946558699173 2.62649071488641e-23 0.0408778714112631 0.883450816679916 miRNATAP -0.232361738096582 0.000529367225285524 NA NA NA hsa-miR-365a-3p BDNF 0.446833934952926 0.00233857759218299 0.0408778714112631 0.883450816679916 miRNATAP -0.31502366808888 0.000131395532237701 NA NA NA hsa-miR-424-5p BDNF 1.48125289532143 9.10372985713165e-19 0.0408778714112631 0.883450816679916 MirTarget;miRNATAP -0.283162731321444 4.92699422656507e-05 NA NA NA hsa-miR-199a-5p BRCA1 -0.364835768178638 0.0435119211101981 1.08313397059632 2.93590901543702e-18 miRanda -0.212781521204852 2.53770827236802e-12 NA NA NA hsa-miR-199b-5p BRCA1 -1.08432682485992 7.68241801134089e-10 1.08313397059632 2.93590901543702e-18 miRanda -0.238487675275486 5.25859993043599e-15 NA NA NA hsa-miR-493-5p BRCA1 -0.471586962917071 0.0221327433064002 1.08313397059632 2.93590901543702e-18 MirTarget -0.130662919015014 1.2917318436997e-06 NA NA NA hsa-miR-193b-3p CASP9 1.72788400801602 3.0722151264559e-21 -0.463384781945098 2.35696508685012e-06 miRNAWalker2_validate -0.154521744765018 3.59150879724078e-12 NA NA NA hsa-miR-424-5p CASP9 1.48125289532143 9.10372985713165e-19 -0.463384781945098 2.35696508685012e-06 mirMAP -0.139144406558183 1.49418335447692e-08 NA NA NA hsa-miR-7-5p CASP9 1.55674721532755 2.41989824363914e-11 -0.463384781945098 2.35696508685012e-06 miRNAWalker2_validate -0.103910716853992 3.37252845720189e-08 NA NA NA hsa-let-7g-5p CCND1 -0.250780249469264 0.00939610188330072 -0.0109881197784345 0.959465409721582 miRNATAP -0.424829740163156 1.3974509451707e-05 NA NA NA hsa-miR-106a-5p CCND1 0.67978010057847 0.00221925869726092 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.290355514799433 2.22440819238953e-12 NA NA NA hsa-miR-1266-5p CCND1 -0.595481713934774 0.0201336437562675 -0.0109881197784345 0.959465409721582 MirTarget -0.139245086566564 0.000186104290921039 NA NA NA hsa-miR-142-3p CCND1 1.12754191614028 1.68798138028946e-08 -0.0109881197784345 0.959465409721582 miRanda -0.212388247517233 4.15485864028608e-06 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-142-5p CCND1 0.288897753038094 0.0900009317815725 -0.0109881197784345 0.959465409721582 PITA -0.191106128320911 0.000532572974747186 NA NA NA hsa-miR-150-5p CCND1 -0.243749814009231 0.331546276920338 -0.0109881197784345 0.959465409721582 mirMAP -0.180131286994855 1.27780213542857e-06 NA NA NA hsa-miR-155-5p CCND1 0.533437622040649 0.00248671179205372 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.205881873012998 0.000104382699617692 26955820 MicroRNA 155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastric cancer cell growth by targeting cyclin D1 staging gastric cancer hsa-miR-15a-5p CCND1 0.783550182002274 2.60699595655907e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.320464086146859 4.59241835770022e-05 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 0.85315666454713 3.79816274836297e-12 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.196519284459032 0.00913339894150689 NA NA NA hsa-miR-16-1-3p CCND1 0.955017760172879 5.95379292601146e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase -0.299307340787817 2.12501301813106e-06 22922827;18483394 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ; sarcoma;lymphoma hsa-miR-16-5p CCND1 0.521122945828175 1.40561786410572e-06 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.36160545188711 2.92815156758109e-05 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-19a-3p CCND1 1.35800152353624 2.80940447111944e-12 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;miRNATAP -0.12556465980021 0.0080645437414565 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 0.757034032029085 2.99828133413343e-07 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase -0.202417906859997 0.00132907107963613 NA NA NA hsa-miR-19b-3p CCND1 0.538732279378089 0.000622008277870679 -0.0109881197784345 0.959465409721582 miRNATAP -0.231848363677157 9.5371115518645e-05 NA NA NA hsa-miR-20a-5p CCND1 1.1531986665452 1.02385132917958e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.150528956777027 0.00569825749150082 NA NA NA hsa-miR-20b-5p CCND1 0.345967670847176 0.232014828043601 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.250103392191291 2.8858693936891e-15 NA NA NA hsa-miR-29b-3p CCND1 -0.110721443686039 0.511264554091106 -0.0109881197784345 0.959465409721582 mirMAP -0.182509877041615 0.00109069300418897 NA NA NA hsa-miR-29c-3p CCND1 -2.08166260448948 8.3238369390898e-24 -0.0109881197784345 0.959465409721582 mirMAP -0.163903476961256 0.000152217345834049 NA NA NA hsa-miR-33a-3p CCND1 0.20371038027126 0.212335697664505 -0.0109881197784345 0.959465409721582 MirTarget -0.204409670414224 0.000471939794699908 NA NA NA hsa-miR-34a-5p CCND1 -0.117372471043915 0.364001947180738 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309736660444851 2.09961171943065e-05 25792709;21399894 This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a ; liver cancer;breast cancer hsa-miR-425-5p CCND1 0.931027421598738 6.46235724408844e-08 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.149225802492201 0.00573052989307961 NA NA NA hsa-miR-497-5p CCND1 -0.966244470847844 5.26505649147857e-12 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.266892367444044 4.86480308910068e-05 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-590-3p CCND1 0.221436901462551 0.0965904764063157 -0.0109881197784345 0.959465409721582 mirMAP -0.238086291527056 0.000767975801470639 NA NA NA hsa-miR-7-1-3p CCND1 1.13646121619622 1.49823237535933e-14 -0.0109881197784345 0.959465409721582 mirMAP -0.221180507811752 0.000359772635429063 NA NA NA hsa-miR-9-5p CCND1 1.65694862043766 2.08325802567323e-05 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.135043708232949 1.13694784335034e-08 NA NA NA hsa-miR-92a-3p CCND1 0.994679542307232 1.32587679156217e-16 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.235491439560111 0.00199944237198536 NA NA NA hsa-miR-942-5p CCND1 0.678652135586536 2.58063518495056e-07 -0.0109881197784345 0.959465409721582 MirTarget -0.230928848103094 0.0011113987419772 NA NA NA hsa-miR-224-3p CCND2 0.502645536188015 0.0081142387260641 0.148711904010299 0.532420631377314 mirMAP -0.312870902501466 8.12446049333883e-09 NA NA NA hsa-miR-27b-3p CCND3 -0.732682718863563 2.26896143573324e-09 -0.048043868607146 0.631560985924681 miRNAWalker2_validate -0.132150579088403 0.000160876577060277 NA NA NA hsa-miR-125b-5p CCNE1 -0.993460109818276 5.07736727659894e-12 1.47144541933057 8.39227402888879e-27 miRNAWalker2_validate -0.277374392819013 5.31956215938705e-11 NA NA NA hsa-miR-151a-3p CCNE1 0.131002217498676 0.295273522160941 1.47144541933057 8.39227402888879e-27 miRNAWalker2_validate -0.150265962772684 0.00298585050443392 NA NA NA hsa-miR-195-5p CCNE1 -1.8367376818177 6.9944883988895e-31 1.47144541933057 8.39227402888879e-27 miRNAWalker2_validate;MirTarget;miRNATAP -0.309888398159948 1.15906313064363e-17 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-215-5p CCNE1 -0.757663683237828 5.72998183244808e-05 1.47144541933057 8.39227402888879e-27 miRNAWalker2_validate -0.129994430039298 9.70603819621136e-05 NA NA NA hsa-miR-26a-5p CCNE1 -1.09269574587169 1.24020612216319e-22 1.47144541933057 8.39227402888879e-27 miRNAWalker2_validate;miRTarBase;miRNATAP -0.491075252836977 6.85651906736478e-21 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-497-5p CCNE1 -0.966244470847844 5.26505649147857e-12 1.47144541933057 8.39227402888879e-27 MirTarget;miRNATAP -0.164722219234429 0.000184434596017171 24112607;25909221;24909281 Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells;miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1 ;; breast cancer;lung cancer;cervical and endocervical cancer hsa-miR-30a-5p CCNE2 -1.79779915425811 1.93360169837799e-26 1.23951713462192 5.15429419774609e-15 miRNATAP -0.160843483864371 5.22163952330061e-05 NA NA NA hsa-miR-369-3p CCNE2 -1.2344419076994 2.66882944171146e-10 1.23951713462192 5.15429419774609e-15 PITA -0.244374203286038 3.35442431580483e-12 NA NA NA hsa-miR-330-3p CDC37 -0.0524949332825773 0.719856123539461 0.153149814038288 0.0510729437063672 PITA;miRNATAP -0.143855603414028 4.45492680559714e-10 NA NA NA hsa-miR-10b-5p CDK2 -0.582989331935508 4.56688330655626e-06 0.825648307855554 1.29874808659333e-17 miRNAWalker2_validate -0.159909593508401 2.19683871071865e-06 NA NA NA hsa-miR-495-3p CDK2 -1.47803501311999 6.88839745293927e-13 0.825648307855554 1.29874808659333e-17 mirMAP -0.121067515894841 3.00810482531006e-09 NA NA NA hsa-miR-101-3p CDK6 -1.91263766544878 1.50270129259053e-39 0.943799976100438 3.26010908820164e-07 mirMAP -0.330251321821837 9.84955273894382e-11 NA NA NA hsa-miR-106a-5p CDK6 0.67978010057847 0.00221925869726092 0.943799976100438 3.26010908820164e-07 mirMAP -0.270806778075969 3.01546103688573e-14 NA NA NA hsa-miR-140-3p CDK6 -0.967453553824782 7.6999446305445e-23 0.943799976100438 3.26010908820164e-07 miRNATAP -0.274830984983389 0.000572898612660903 NA NA NA hsa-miR-141-3p CDK6 0.730011517758706 0.000120338355004032 0.943799976100438 3.26010908820164e-07 TargetScan;miRNATAP -0.144552658761934 0.000685853549803452 NA NA NA hsa-miR-142-5p CDK6 0.288897753038094 0.0900009317815725 0.943799976100438 3.26010908820164e-07 PITA -0.139817988293101 0.00345142119103429 NA NA NA hsa-miR-146a-5p CDK6 -0.0201236699646614 0.905882759106561 0.943799976100438 3.26010908820164e-07 mirMAP -0.215910726342031 5.89162734992982e-06 NA NA NA hsa-miR-148a-3p CDK6 -0.428944290834563 0.00954246923521465 0.943799976100438 3.26010908820164e-07 mirMAP -0.352194126420792 2.47922792703682e-13 NA NA NA hsa-miR-148a-5p CDK6 -1.00478606532747 1.38045244999229e-07 0.943799976100438 3.26010908820164e-07 mirMAP -0.168311831982054 6.19585640247235e-05 NA NA NA hsa-miR-15a-5p CDK6 0.783550182002274 2.60699595655907e-11 0.943799976100438 3.26010908820164e-07 miRNATAP -0.285921263186907 2.61019491684346e-05 NA NA NA hsa-miR-16-1-3p CDK6 0.955017760172879 5.95379292601146e-11 0.943799976100438 3.26010908820164e-07 mirMAP -0.191844024126834 0.000473356615206941 NA NA NA hsa-miR-16-5p CDK6 0.521122945828175 1.40561786410572e-06 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase -0.390172822616052 1.63474102862122e-07 NA NA NA hsa-miR-191-5p CDK6 0.648528205617075 5.59342922179914e-07 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase -0.304048292825889 9.20052672769938e-07 NA NA NA hsa-miR-195-5p CDK6 -1.8367376818177 6.9944883988895e-31 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase -0.147548431452902 0.00221639504281517 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-200a-3p CDK6 0.607140814457753 0.00289840524858752 0.943799976100438 3.26010908820164e-07 miRNATAP -0.141449889886458 0.00036916846884784 24009066 microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6 liver cancer hsa-miR-200b-3p CDK6 0.0717138787925347 0.682858087587209 0.943799976100438 3.26010908820164e-07 mirMAP -0.172143765246203 0.000203839288085545 NA NA NA hsa-miR-20b-5p CDK6 0.345967670847176 0.232014828043601 0.943799976100438 3.26010908820164e-07 mirMAP -0.319548642762033 7.55584014107553e-34 26166554 The transfection of miR-20b into EJ cells induced G1 phase cell cycle arrest via the decreased expression of cyclin D1 CDK2 and CDK6 without affecting another G1 phase cell cycle regulator cyclin E bladder cancer hsa-miR-217 CDK6 -1.35391381055929 2.42394951427902e-09 0.943799976100438 3.26010908820164e-07 mirMAP -0.101972431424956 0.00385414956789609 NA NA NA hsa-miR-218-5p CDK6 -1.0725338636959 3.61493686604269e-09 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate -0.157173497673979 0.000358234774549337 23996750 Ectopic expression of miR-218 in HepG2 cells resulted in suppressed cell proliferation and enhanced cell apoptosis as well as the down-regulation of Bmi-1 and CDK6 mRNA and protein expressions P<0.05; The low-expression of miR-218 is correlated with malignant clinicopathological characteristics of HCC and miR-218 may inhibit cell proliferation and promote cell apoptosis by down-regulating Bmi-1 and CDK6 in HCC malignant trasformation liver cancer hsa-miR-23b-3p CDK6 -0.497563803223134 3.31483353357535e-05 0.943799976100438 3.26010908820164e-07 mirMAP -0.187559518282179 0.00569215928221825 NA NA NA hsa-miR-26a-5p CDK6 -1.09269574587169 1.24020612216319e-22 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.299394118060181 1.85556297732571e-05 26314438 Maxvision immunohistochemistry technique was used to detect the expression level of CDK6 and miR-26a in tissue of 20 ENKTCL cases 10 cases of proliferative lymphadenitis and 10 samples of normal lymph node respectively; The possible role of miR-26a and its target gene CDK6 in genesis and development of ENKTCL were analyzed according to the clinical features of ENKTCL patients; Correlation analysis showed that there was significant negative correlation between miR-26a expression and CDK6 expression r = -0.54 P = 0.04 lymphoma hsa-miR-26b-5p CDK6 -0.254478038884324 0.0285227763044636 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.366507052753924 1.49769255271943e-07 NA NA NA hsa-miR-27b-3p CDK6 -0.732682718863563 2.26896143573324e-09 0.943799976100438 3.26010908820164e-07 mirMAP -0.25498599690856 9.88663275746304e-05 NA NA NA hsa-miR-27b-5p CDK6 0.580870079022649 0.000181529223377382 0.943799976100438 3.26010908820164e-07 mirMAP -0.136352328908371 0.00915378846518187 NA NA NA hsa-miR-29b-3p CDK6 -0.110721443686039 0.511264554091106 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.231353291571021 1.47948165135711e-06 23245396;25472644;26180082;23591808;27230400;20086245 The IFN-γ-induced G1-arrest of melanoma cells involves down-regulation of CDK6 which we proved to be a direct target of miR-29 in these cells;Moreover miR-29b inhibited the expression of MCL1 and CDK6;Knockdown of NTSR1 increased the expression of miR-29b-1 and miR-129-3p which were responsible for the decreased CDK6 expression;Here we have identified the oncogene cyclin-dependent protein kinase 6 CDK6 as a direct target of miR-29b in lung cancer;MiR 29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6; In this study we investigated the role of miR-29b as a novel regulator of CDK6 using bioinformatics methods; We demonstrated that CDK6 can be downregulated by miR-29b via binding to the 3'-UTR region in osteosarcoma cells; Furthermore we identified an inverse correlation between miR-29b and CDK6 protein levels in osteosarcoma tissues; The results revealed that miR-29b acts as a tumor suppressor of osteosarcoma by targeting CDK6 in the proliferation and migration processes;microRNA expression profile and identification of miR 29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma; Furthermore we demonstrate miR-29 inhibition of CDK6 protein and mRNA levels by direct binding to 3'-untranslated region; Inverse correlation between miR-29 and CDK6 was observed in MCL ;;;;; melanoma;colorectal cancer;glioblastoma;lung cancer;sarcoma;lymphoma hsa-miR-29c-3p CDK6 -2.08166260448948 8.3238369390898e-24 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.263284323247694 8.29389379067708e-13 26396669 Furthermore through qPCR and Western blot assays confirmed that overexpression of miR-29c reduced CDK6 mRNA and protein levels; miR-29c could inhibit the proliferation migration and invasion of bladder cancer cells via regulating CDK6 bladder cancer hsa-miR-30a-3p CDK6 -2.26144364746452 8.12421214153823e-31 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;mirMAP -0.140198240628917 0.000324956485864008 NA NA NA hsa-miR-30a-5p CDK6 -1.79779915425811 1.93360169837799e-26 0.943799976100438 3.26010908820164e-07 mirMAP -0.244091558945119 7.330875395431e-08 NA NA NA hsa-miR-30b-5p CDK6 -0.400238605368173 0.00346540992719245 0.943799976100438 3.26010908820164e-07 mirMAP -0.434806721700384 7.69264513504911e-14 NA NA NA hsa-miR-30c-5p CDK6 0.021222006155897 0.886366656528128 0.943799976100438 3.26010908820164e-07 mirMAP -0.3418227405519 2.85445288861842e-10 NA NA NA hsa-miR-30d-3p CDK6 -0.577371911152798 2.02950840095287e-06 0.943799976100438 3.26010908820164e-07 mirMAP -0.503232545055278 1.21266173811556e-14 NA NA NA hsa-miR-30d-5p CDK6 -0.38399848121878 0.000171129616944749 0.943799976100438 3.26010908820164e-07 mirMAP -0.478956981188774 1.25587674803108e-09 NA NA NA hsa-miR-30e-3p CDK6 -0.890635378639789 1.65740480611339e-16 0.943799976100438 3.26010908820164e-07 mirMAP -0.493162425301019 8.88393527920392e-12 NA NA NA hsa-miR-30e-5p CDK6 -1.02114836019762 6.81961221797866e-17 0.943799976100438 3.26010908820164e-07 mirMAP -0.527037067797998 5.6019097407655e-17 NA NA NA hsa-miR-32-5p CDK6 -0.317310201890053 0.0102525324475293 0.943799976100438 3.26010908820164e-07 miRNATAP -0.343788737898722 1.50852274763283e-07 NA NA NA hsa-miR-320a CDK6 0.801356001806321 4.91397101474502e-09 0.943799976100438 3.26010908820164e-07 PITA;miRNATAP -0.215899862858631 0.000228990035954073 NA NA NA hsa-miR-335-3p CDK6 0.336785882180547 0.0542446207938138 0.943799976100438 3.26010908820164e-07 mirMAP -0.134100857118668 0.00395950799932265 NA NA NA hsa-miR-335-5p CDK6 -1.17227779671552 1.49282618530733e-10 0.943799976100438 3.26010908820164e-07 mirMAP -0.17718916608193 4.69104859301016e-05 NA NA NA hsa-miR-340-5p CDK6 -0.608415693437977 4.44345153563513e-05 0.943799976100438 3.26010908820164e-07 mirMAP -0.17760804422206 0.00108030432977789 NA NA NA hsa-miR-34a-5p CDK6 -0.117372471043915 0.364001947180738 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.474044531250989 1.69147353058574e-14 21702042;26104764 Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004 ; bladder cancer;lung cancer hsa-miR-362-5p CDK6 0.41089772861323 0.0404254902071382 0.943799976100438 3.26010908820164e-07 mirMAP -0.260229145155647 7.00102306080077e-11 NA NA NA hsa-miR-374a-3p CDK6 -0.299190081500425 0.00682975596757891 0.943799976100438 3.26010908820164e-07 mirMAP -0.380845410382319 2.04485987693411e-07 NA NA NA hsa-miR-374a-5p CDK6 -0.621903385111545 6.61791773205282e-12 0.943799976100438 3.26010908820164e-07 mirMAP -0.405061325584562 4.73802604337785e-06 NA NA NA hsa-miR-374b-5p CDK6 -0.288413933608091 0.0041474558664058 0.943799976100438 3.26010908820164e-07 mirMAP -0.474069124376016 3.78110860368437e-09 NA NA NA hsa-miR-378a-3p CDK6 -1.50453783521372 9.41694954361173e-17 0.943799976100438 3.26010908820164e-07 mirMAP -0.209704195412153 1.273508200611e-06 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-429 CDK6 0.559451508722375 0.00563641638673083 0.943799976100438 3.26010908820164e-07 mirMAP;miRNATAP -0.106003536253203 0.0083665250305265 NA NA NA hsa-miR-497-5p CDK6 -0.966244470847844 5.26505649147857e-12 0.943799976100438 3.26010908820164e-07 miRNATAP -0.336887999296509 2.21691851621954e-09 NA NA NA hsa-miR-500a-5p CDK6 0.675401699376111 8.24389004707854e-05 0.943799976100438 3.26010908820164e-07 mirMAP -0.136463332134803 0.0038451740739746 NA NA NA hsa-miR-502-3p CDK6 -0.165138869760313 0.106881047403914 0.943799976100438 3.26010908820164e-07 PITA;miRNATAP -0.296409566969119 0.000210944839114926 NA NA NA hsa-miR-582-5p CDK6 -0.0366995972742474 0.821827119138923 0.943799976100438 3.26010908820164e-07 miRNATAP -0.222480119114911 7.9439037894028e-06 NA NA NA hsa-miR-590-3p CDK6 0.221436901462551 0.0965904764063157 0.943799976100438 3.26010908820164e-07 mirMAP;miRNATAP -0.167194733039206 0.00641945407308449 NA NA NA hsa-miR-660-5p CDK6 -0.202705992887645 0.101093376073573 0.943799976100438 3.26010908820164e-07 mirMAP -0.39601322603476 1.31183015377543e-09 NA NA NA hsa-miR-664a-3p CDK6 -0.256108763664991 0.0513188660751664 0.943799976100438 3.26010908820164e-07 mirMAP -0.32103643789594 1.87674231980515e-07 NA NA NA hsa-miR-7-1-3p CDK6 1.13646121619622 1.49823237535933e-14 0.943799976100438 3.26010908820164e-07 mirMAP -0.167417347789213 0.0018262424002125 NA NA NA hsa-miR-9-5p CDK6 1.65694862043766 2.08325802567323e-05 0.943799976100438 3.26010908820164e-07 mirMAP -0.168540643433085 5.15188603206423e-17 NA NA NA hsa-let-7a-5p CDKN1A -0.439381775414001 3.1119785480023e-05 0.127907055720529 0.358633438275103 miRNAWalker2_validate;MirTarget;TargetScan -0.157887314863044 0.00607392500892242 NA NA NA hsa-let-7c-5p CDKN1A -2.07953368242668 3.46048888391218e-23 0.127907055720529 0.358633438275103 MirTarget -0.154966489020611 1.40043705353072e-08 NA NA NA hsa-let-7d-5p CDKN1A 0.481757661442508 3.66030810124939e-07 0.127907055720529 0.358633438275103 MirTarget -0.318303233510587 5.28719683231192e-07 NA NA NA hsa-let-7f-5p CDKN1A -0.441845198213823 0.00242957484218694 0.127907055720529 0.358633438275103 miRNAWalker2_validate;MirTarget -0.182282405867162 1.04368032915846e-05 NA NA NA hsa-let-7g-5p CDKN1A -0.250780249469264 0.00939610188330072 0.127907055720529 0.358633438275103 MirTarget -0.398859680782031 1.57079778109355e-10 NA NA NA hsa-let-7i-5p CDKN1A 0.249440992451337 0.00426823922424972 0.127907055720529 0.358633438275103 MirTarget -0.294915458886481 2.44467484945999e-05 NA NA NA hsa-miR-101-3p CDKN1A -1.91263766544878 1.50270129259053e-39 0.127907055720529 0.358633438275103 MirTarget -0.258645074781103 9.13055424902711e-12 NA NA NA hsa-miR-106a-5p CDKN1A 0.67978010057847 0.00221925869726092 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.127737584115643 2.20859465651693e-06 25510666 After prediction with online software we further used dual-luciferase reporter gene assay to ensure that TP53INP1 and CDKN1A might be the direct targets of miR-106a liver cancer hsa-miR-106b-5p CDKN1A 0.50378717276868 1.45412404526866e-05 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.395677807466644 6.77429329572222e-15 NA NA NA hsa-miR-20b-5p CDKN1A 0.345967670847176 0.232014828043601 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.104762985609593 4.52354521296224e-07 NA NA NA hsa-miR-28-5p CDKN1A -0.026996999089909 0.733047113251652 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.739238141393868 4.97263373683604e-23 NA NA NA hsa-miR-30b-3p CDKN1A -0.338530747940815 0.0223424741180399 0.127907055720529 0.358633438275103 MirTarget -0.214381215718527 1.34523563618692e-07 NA NA NA hsa-miR-335-5p CDKN1A -1.17227779671552 1.49282618530733e-10 0.127907055720529 0.358633438275103 miRNAWalker2_validate -0.233668033663431 2.16898184164444e-13 NA NA NA hsa-miR-345-5p CDKN1A 0.882162580294938 2.95895678052434e-07 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget -0.22316248649142 7.71072127808706e-11 NA NA NA hsa-miR-363-3p CDKN1A -0.608157508016978 0.0186109501272176 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase -0.113214661296052 1.07835696522481e-06 NA NA NA hsa-miR-423-5p CDKN1A 0.60141781325829 1.62940950644999e-07 0.127907055720529 0.358633438275103 MirTarget -0.249258805343378 1.73973574563061e-06 NA NA NA hsa-miR-429 CDKN1A 0.559451508722375 0.00563641638673083 0.127907055720529 0.358633438275103 miRNATAP -0.109329855441573 0.000248387440193944 NA NA NA hsa-miR-491-5p CDKN1A -0.541680329196715 0.00135829217561865 0.127907055720529 0.358633438275103 miRanda -0.113024010321719 0.00252753472048722 NA NA NA hsa-miR-582-5p CDKN1A -0.0366995972742474 0.821827119138923 0.127907055720529 0.358633438275103 miRNATAP -0.162063113723445 1.25361670221294e-05 NA NA NA hsa-miR-654-3p CDKN1A -1.77960431554497 1.76486415439529e-14 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase -0.117614114313009 3.17265104059811e-06 NA NA NA hsa-miR-93-5p CDKN1A 1.61042951896619 5.1280369606967e-24 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.131898490796649 0.000276995054107702 25633810 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC liver cancer hsa-miR-98-5p CDKN1A 0.0176698653376732 0.858271091070735 0.127907055720529 0.358633438275103 miRNAWalker2_validate;MirTarget -0.236406574284277 0.000129077758881236 NA NA NA hsa-miR-221-3p CDKN1B 0.410625614724387 0.000741090075261272 -0.21524734266819 0.0145768962530629 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.150679309763823 1.4952160991175e-06 23637992;19953484;23939688;19126397;20146005;23967190;17569667;22992757;17721077;20461750 miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression progression;;;;staging;tumorigenesis;;;;;poor survival breast cancer;glioblastoma;breast cancer;melanoma;liver cancer;pancreatic cancer;prostate cancer;breast cancer;glioblastoma;ovarian cancer hsa-miR-222-3p CDKN1B 1.08197052578759 2.32604040301699e-14 -0.21524734266819 0.0145768962530629 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.149040440792648 1.14434324825478e-08 19953484;26912358;24895988;24137356;17569667;27282281;20461750 Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;Besides microvesicle marker characterization we evidenced that miR-222 exosomal expression mostly reflected its abundance in the cells of origin correctly paralleled by repression of its target genes such as p27Kip1 and induction of the PI3K/AKT pathway thus confirming its functional implication in cancer;MiR-222 plays an important role in the tumorigenesis of CC possibly by specifically down-regulating p27Kip1 and PTEN;miR 222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1; miR-222 upregulation induced an enhancement of ovarian cancer cell proliferation potential possibly by downregulating its target P27Kip1; A bioinformatic analysis showed that the 3'-UTR of the P27Kip1 mRNA contained a highly-conserved putative miR-222 binding site; Luciferase reporter assays demonstrated that P27Kip1 was a direct target of miR-222; Consistently there was an inverse correlation between the P27Kip1 and miR-222 expression levels in the ovarian cancer cell lines and tissues;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;miR 222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27kip1 expression; Immunofluorescence showed that miR-222 altered the subcellular location of p27kip1 in nucleus; The results showed that downregulation of miR-222 in MCF-7/Adr increased sensitivity to Adr and Adr-induced apoptosis and arrested the cells in G1 phase accompanied by more expressions of p27kip1 especially in nucleus; Taken together the results found that miR-222 induced Adr-resistance at least in part via suppressing p27kip1 expression and altering its subcellular localization and miR-222 inhibitors could reverse Adr-resistance of breast cancer cells;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression ;;tumorigenesis;;;drug resistance;poor survival glioblastoma;melanoma;cervical and endocervical cancer;ovarian cancer;prostate cancer;breast cancer;ovarian cancer hsa-miR-455-5p CDKN1B 1.408595672323 5.52039116456697e-22 -0.21524734266819 0.0145768962530629 miRanda;miRNATAP -0.182727098870007 1.24516427073226e-13 NA NA NA hsa-miR-222-5p CHAD -0.100210968274912 0.597652996754512 -3.01863679871828 1.46902873833321e-20 MirTarget -0.22910768800967 0.00316983835033369 NA NA NA hsa-miR-330-5p CHRM1 0.944693925383906 5.04972895657346e-13 -3.191066032775 1.42076807915437e-15 MirTarget;miRanda;miRNATAP -0.476404378800541 0.000386537940496403 NA NA NA hsa-miR-342-3p CHRM1 0.99756868977753 9.28499866272332e-10 -3.191066032775 1.42076807915437e-15 miRanda -0.445503318650878 3.67988685091958e-05 NA NA NA hsa-let-7g-5p COL1A1 -0.250780249469264 0.00939610188330072 3.60845872085475 1.44319508672333e-31 miRNATAP -0.48707193020329 0.00111943678913819 NA NA NA hsa-miR-106a-5p COL1A1 0.67978010057847 0.00221925869726092 3.60845872085475 1.44319508672333e-31 mirMAP -0.378624701554961 2.31668674743769e-09 NA NA NA hsa-miR-106b-5p COL1A1 0.50378717276868 1.45412404526866e-05 3.60845872085475 1.44319508672333e-31 mirMAP -0.355915743624106 0.00383148368810334 NA NA NA hsa-miR-126-5p COL1A1 -0.953529188793816 7.91719143295591e-16 3.60845872085475 1.44319508672333e-31 miRNATAP -0.738305464530461 2.2420465965451e-10 NA NA NA hsa-miR-150-5p COL1A1 -0.243749814009231 0.331546276920338 3.60845872085475 1.44319508672333e-31 miRNATAP -0.217456444922139 0.000131201787929862 NA NA NA hsa-miR-17-5p COL1A1 1.41924888736771 2.75805544953758e-18 3.60845872085475 1.44319508672333e-31 mirMAP -0.261608419386794 0.00211205802512542 NA NA NA hsa-miR-20a-5p COL1A1 1.1531986665452 1.02385132917958e-11 3.60845872085475 1.44319508672333e-31 mirMAP -0.337744431652592 4.27390599981122e-05 NA NA NA hsa-miR-20b-5p COL1A1 0.345967670847176 0.232014828043601 3.60845872085475 1.44319508672333e-31 mirMAP -0.324354003057995 2.56729400239008e-11 NA NA NA hsa-miR-23b-5p COL1A1 0.141208007066527 0.420202986869364 3.60845872085475 1.44319508672333e-31 mirMAP -0.454135610386432 5.61640352079574e-08 NA NA NA hsa-miR-29a-3p COL1A1 -1.26881270980079 2.82496991513463e-22 3.60845872085475 1.44319508672333e-31 miRNATAP -0.755516505509511 2.37766075876678e-13 NA NA NA hsa-miR-29b-3p COL1A1 -0.110721443686039 0.511264554091106 3.60845872085475 1.44319508672333e-31 miRNAWalker2_validate;miRTarBase;miRNATAP -0.693661041987726 4.99341901437697e-17 NA NA NA hsa-miR-29c-3p COL1A1 -2.08166260448948 8.3238369390898e-24 3.60845872085475 1.44319508672333e-31 miRNAWalker2_validate;miRTarBase;miRNATAP -0.614769445875042 3.42494446797044e-22 NA NA NA hsa-miR-30a-3p COL1A1 -2.26144364746452 8.12421214153823e-31 3.60845872085475 1.44319508672333e-31 mirMAP -0.307035022599355 7.16091653614776e-06 NA NA NA hsa-miR-30b-3p COL1A1 -0.338530747940815 0.0223424741180399 3.60845872085475 1.44319508672333e-31 miRNATAP -0.563073741013859 4.14464482407918e-09 NA NA NA hsa-miR-30d-3p COL1A1 -0.577371911152798 2.02950840095287e-06 3.60845872085475 1.44319508672333e-31 mirMAP -1.01274432312451 5.34689254881346e-19 NA NA NA hsa-miR-30e-3p COL1A1 -0.890635378639789 1.65740480611339e-16 3.60845872085475 1.44319508672333e-31 mirMAP -0.918604723901982 4.3967834429653e-13 NA NA NA hsa-miR-338-3p COL1A1 -0.948755228846395 8.99167125682392e-08 3.60845872085475 1.44319508672333e-31 miRanda;miRNATAP -0.504275000046221 1.36172634799256e-10 NA NA NA hsa-miR-361-3p COL1A1 0.272298288982435 0.0147874880476998 3.60845872085475 1.44319508672333e-31 PITA -0.461502009370834 0.000334039259550113 NA NA NA hsa-miR-590-3p COL1A1 0.221436901462551 0.0965904764063157 3.60845872085475 1.44319508672333e-31 miRanda -0.469005029407127 1.24860032120008e-05 NA NA NA hsa-miR-92a-1-5p COL1A1 1.41314158431819 2.67965667765933e-11 3.60845872085475 1.44319508672333e-31 MirTarget -0.273853190960453 3.43626577630272e-05 NA NA NA hsa-let-7a-3p COL1A2 0.0966652362351867 0.423761916840503 2.67440414460036 8.77041031170282e-20 MirTarget -0.313413654613553 0.00466605707314106 NA NA NA hsa-let-7g-5p COL1A2 -0.250780249469264 0.00939610188330072 2.67440414460036 8.77041031170282e-20 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.364074886804212 0.00881990633021969 NA NA NA hsa-miR-19a-3p COL1A2 1.35800152353624 2.80940447111944e-12 2.67440414460036 8.77041031170282e-20 MirTarget -0.332207431257499 5.67543084282414e-07 NA NA NA hsa-miR-19b-3p COL1A2 0.538732279378089 0.000622008277870679 2.67440414460036 8.77041031170282e-20 MirTarget -0.59226982751577 7.2435926421866e-13 NA NA NA hsa-miR-25-3p COL1A2 0.76549796417801 3.32282098247097e-11 2.67440414460036 8.77041031170282e-20 MirTarget;miRNATAP -0.347517525858949 0.00222151263145703 NA NA NA hsa-miR-26a-5p COL1A2 -1.09269574587169 1.24020612216319e-22 2.67440414460036 8.77041031170282e-20 MirTarget;miRNATAP -0.367832009718336 0.00133894105701387 NA NA NA hsa-miR-26b-5p COL1A2 -0.254478038884324 0.0285227763044636 2.67440414460036 8.77041031170282e-20 MirTarget;miRNATAP -0.718116378418528 2.33518730766038e-10 NA NA NA hsa-miR-29a-3p COL1A2 -1.26881270980079 2.82496991513463e-22 2.67440414460036 8.77041031170282e-20 miRNATAP -0.621365355705265 1.09712817620421e-10 NA NA NA hsa-miR-29b-3p COL1A2 -0.110721443686039 0.511264554091106 2.67440414460036 8.77041031170282e-20 miRNATAP -0.662281324528488 5.48526034135374e-18 NA NA NA hsa-miR-29c-3p COL1A2 -2.08166260448948 8.3238369390898e-24 2.67440414460036 8.77041031170282e-20 miRNAWalker2_validate;miRTarBase;miRNATAP -0.501355865703863 3.80993079719404e-17 NA NA NA hsa-miR-30a-3p COL1A2 -2.26144364746452 8.12421214153823e-31 2.67440414460036 8.77041031170282e-20 MirTarget -0.192543066949851 0.00255976744747418 NA NA NA hsa-miR-30d-3p COL1A2 -0.577371911152798 2.02950840095287e-06 2.67440414460036 8.77041031170282e-20 MirTarget -0.910264089366439 7.99447576004809e-18 NA NA NA hsa-miR-30e-3p COL1A2 -0.890635378639789 1.65740480611339e-16 2.67440414460036 8.77041031170282e-20 MirTarget -0.711518998980638 2.02501901497149e-09 NA NA NA hsa-miR-32-5p COL1A2 -0.317310201890053 0.0102525324475293 2.67440414460036 8.77041031170282e-20 MirTarget;miRNATAP -0.727915936212518 6.43832518085866e-12 NA NA NA hsa-miR-33a-3p COL1A2 0.20371038027126 0.212335697664505 2.67440414460036 8.77041031170282e-20 MirTarget -0.512792781647199 3.24945943808124e-10 NA NA NA hsa-miR-363-3p COL1A2 -0.608157508016978 0.0186109501272176 2.67440414460036 8.77041031170282e-20 MirTarget -0.359029150456871 9.34526691915003e-13 NA NA NA hsa-miR-590-3p COL1A2 0.221436901462551 0.0965904764063157 2.67440414460036 8.77041031170282e-20 miRanda -0.497732708770646 5.48581795793823e-07 NA NA NA hsa-miR-7-1-3p COL1A2 1.13646121619622 1.49823237535933e-14 2.67440414460036 8.77041031170282e-20 mirMAP -0.479173395898502 3.48645475540795e-08 NA NA NA hsa-miR-92a-3p COL1A2 0.994679542307232 1.32587679156217e-16 2.67440414460036 8.77041031170282e-20 MirTarget;miRNATAP -0.534139883289929 5.86060358609946e-07 NA NA NA hsa-miR-106a-5p COL2A1 0.67978010057847 0.00221925869726092 3.29753960746886 3.63764825689287e-19 miRNAWalker2_validate -0.24221001544402 0.00116953678091816 NA NA NA hsa-miR-148a-3p COL2A1 -0.428944290834563 0.00954246923521465 3.29753960746886 3.63764825689287e-19 MirTarget;miRNATAP -0.442222167115675 9.95345354795032e-06 NA NA NA hsa-miR-29a-3p COL2A1 -1.26881270980079 2.82496991513463e-22 3.29753960746886 3.63764825689287e-19 MirTarget;miRNATAP -0.720334849200765 2.63429660142174e-09 NA NA NA hsa-miR-29b-3p COL2A1 -0.110721443686039 0.511264554091106 3.29753960746886 3.63764825689287e-19 MirTarget;miRNATAP -0.268994368979971 0.00665149360805195 NA NA NA hsa-miR-29c-3p COL2A1 -2.08166260448948 8.3238369390898e-24 3.29753960746886 3.63764825689287e-19 MirTarget;miRNATAP -0.601144534851503 9.56786193750431e-16 NA NA NA hsa-miR-100-5p COL4A1 -1.85857794619369 1.248973638996e-25 2.83937959905908 7.34135834575235e-47 miRNAWalker2_validate -0.17528260776814 0.000530599939471027 NA NA NA hsa-miR-148a-3p COL4A1 -0.428944290834563 0.00954246923521465 2.83937959905908 7.34135834575235e-47 miRNATAP -0.286681398841711 4.15638136662523e-07 NA NA NA hsa-miR-29a-3p COL4A1 -1.26881270980079 2.82496991513463e-22 2.83937959905908 7.34135834575235e-47 miRNAWalker2_validate;miRTarBase;miRNATAP -0.458043675150706 2.0846229509702e-11 NA NA NA hsa-miR-29b-3p COL4A1 -0.110721443686039 0.511264554091106 2.83937959905908 7.34135834575235e-47 miRNAWalker2_validate;miRTarBase;miRNATAP -0.392743814870725 1.02245016183976e-12 NA NA NA hsa-miR-29c-3p COL4A1 -2.08166260448948 8.3238369390898e-24 2.83937959905908 7.34135834575235e-47 miRNAWalker2_validate;miRTarBase;miRNATAP -0.393329554134978 7.86673995187341e-21 NA NA NA hsa-miR-362-3p COL4A1 -0.697212068252854 2.61718493418184e-06 2.83937959905908 7.34135834575235e-47 miRanda -0.331300898192448 1.43501501024564e-07 NA NA NA hsa-miR-429 COL4A1 0.559451508722375 0.00563641638673083 2.83937959905908 7.34135834575235e-47 miRanda;miRNATAP -0.269582298220837 4.97271679157673e-09 NA NA NA hsa-miR-590-3p COL4A1 0.221436901462551 0.0965904764063157 2.83937959905908 7.34135834575235e-47 miRanda -0.189613239353297 0.00780601536972556 NA NA NA hsa-miR-628-5p COL4A1 -0.554239048796013 4.92386883216087e-05 2.83937959905908 7.34135834575235e-47 PITA;miRNATAP -0.212468502409852 0.00207735055800124 NA NA NA hsa-miR-99a-5p COL4A1 -2.344442285007 7.11841214134739e-24 2.83937959905908 7.34135834575235e-47 miRNAWalker2_validate -0.304245005031332 7.45376710248459e-16 NA NA NA hsa-miR-10a-5p COL4A2 -0.316491613573591 0.148093857656453 2.58872062468549 1.03105600926525e-43 miRNAWalker2_validate -0.112103186643999 0.00573612050062258 NA NA NA hsa-miR-1266-5p COL4A2 -0.595481713934774 0.0201336437562675 2.58872062468549 1.03105600926525e-43 MirTarget -0.159451882030184 5.40322182963185e-06 NA NA NA hsa-miR-26b-5p COL4A2 -0.254478038884324 0.0285227763044636 2.58872062468549 1.03105600926525e-43 miRNAWalker2_validate -0.365751393315261 1.63261727959989e-06 NA NA NA hsa-miR-29a-3p COL4A2 -1.26881270980079 2.82496991513463e-22 2.58872062468549 1.03105600926525e-43 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.397776975185521 6.58826142516059e-10 NA NA NA hsa-miR-29b-3p COL4A2 -0.110721443686039 0.511264554091106 2.58872062468549 1.03105600926525e-43 miRTarBase;MirTarget;miRNATAP -0.297124758156548 1.25722392484829e-08 NA NA NA hsa-miR-29c-3p COL4A2 -2.08166260448948 8.3238369390898e-24 2.58872062468549 1.03105600926525e-43 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.360294864916402 8.15214180862851e-20 NA NA NA hsa-miR-135b-5p COL4A3 1.5570143078477 4.60753610971455e-13 -0.782054509077127 0.02643023965868 MirTarget -0.294568538391922 2.21068235211477e-05 NA NA NA hsa-miR-15b-3p COL4A3 1.05020782493504 6.38723677324836e-14 -0.782054509077127 0.02643023965868 mirMAP -0.302748826283572 0.00481646275778777 NA NA NA hsa-miR-17-5p COL4A3 1.41924888736771 2.75805544953758e-18 -0.782054509077127 0.02643023965868 MirTarget;TargetScan;miRNATAP -0.474994807375516 1.56035261597968e-07 NA NA NA hsa-miR-193a-3p COL4A3 0.22120710726779 0.111827069464729 -0.782054509077127 0.02643023965868 miRanda -0.31606072415711 0.00436979800688799 NA NA NA hsa-miR-200b-3p COL4A3 0.0717138787925347 0.682858087587209 -0.782054509077127 0.02643023965868 TargetScan -0.272464503566359 0.0018935881077338 NA NA NA hsa-miR-200c-3p COL4A3 0.630251054099546 0.000131975031451555 -0.782054509077127 0.02643023965868 miRNATAP -0.415816304412086 6.66595301037672e-06 NA NA NA hsa-miR-20a-5p COL4A3 1.1531986665452 1.02385132917958e-11 -0.782054509077127 0.02643023965868 MirTarget;miRNATAP -0.392768800784149 8.98690191829031e-06 NA NA NA hsa-miR-3065-3p COL4A3 -0.543069092777161 0.0213164885178151 -0.782054509077127 0.02643023965868 miRNATAP -0.238070711384903 0.000242525178241011 NA NA NA hsa-miR-429 COL4A3 0.559451508722375 0.00563641638673083 -0.782054509077127 0.02643023965868 miRanda;miRNATAP -0.280750091585043 0.000207463244000149 NA NA NA hsa-miR-93-5p COL4A3 1.61042951896619 5.1280369606967e-24 -0.782054509077127 0.02643023965868 MirTarget;miRNATAP -0.242410348793794 0.00862932993111204 NA NA NA hsa-miR-944 COL4A3 1.47323925060177 2.61626403984929e-13 -0.782054509077127 0.02643023965868 mirMAP -0.478690604365538 6.48149314258799e-11 NA NA NA hsa-let-7a-3p COL4A4 0.0966652362351867 0.423761916840503 -0.708088617940005 0.024215074145821 mirMAP -0.496661846944635 1.23290886540123e-05 NA NA NA hsa-miR-130a-3p COL4A4 0.67051191119964 4.89747518735144e-06 -0.708088617940005 0.024215074145821 mirMAP -0.550300775161876 1.91951381674278e-09 NA NA NA hsa-miR-203a-3p COL4A4 0.0441399794719697 0.880456392176704 -0.708088617940005 0.024215074145821 MirTarget -0.301669978597768 5.0490279352704e-11 NA NA NA hsa-miR-224-3p COL4A4 0.502645536188015 0.0081142387260641 -0.708088617940005 0.024215074145821 mirMAP -0.267911813544384 0.000216111569320756 NA NA NA hsa-miR-301a-3p COL4A4 2.14132004241926 4.46255413526808e-25 -0.708088617940005 0.024215074145821 mirMAP -0.213497182785423 0.000695791301492209 NA NA NA hsa-miR-429 COL4A4 0.559451508722375 0.00563641638673083 -0.708088617940005 0.024215074145821 miRNATAP -0.192455771165725 0.0044579424247129 NA NA NA hsa-miR-454-3p COL4A4 1.54137391927201 4.15861570449376e-20 -0.708088617940005 0.024215074145821 mirMAP -0.229885964813059 0.00348634494695519 NA NA NA hsa-miR-576-5p COL4A4 0.940432050128373 6.90227595663302e-12 -0.708088617940005 0.024215074145821 PITA -0.366430556215845 0.000184558130658636 NA NA NA hsa-miR-589-3p COL4A4 1.59559692667315 6.2886410639161e-15 -0.708088617940005 0.024215074145821 mirMAP -0.317971970531176 2.44824926370596e-06 NA NA NA hsa-miR-944 COL4A4 1.47323925060177 2.61626403984929e-13 -0.708088617940005 0.024215074145821 PITA;mirMAP;miRNATAP -0.452488372581352 3.87495267666885e-12 NA NA NA hsa-let-7g-5p COL4A5 -0.250780249469264 0.00939610188330072 2.09669254192623 4.08340113795531e-24 miRNATAP -0.343418980303274 0.000493512224578597 NA NA NA hsa-miR-217 COL4A5 -1.35391381055929 2.42394951427902e-09 2.09669254192623 4.08340113795531e-24 PITA;miRanda -0.158455203159578 0.000104719539687772 NA NA NA hsa-miR-29a-3p COL4A5 -1.26881270980079 2.82496991513463e-22 2.09669254192623 4.08340113795531e-24 miRNATAP -0.236900337209868 0.000644424930953159 NA NA NA hsa-miR-29b-3p COL4A5 -0.110721443686039 0.511264554091106 2.09669254192623 4.08340113795531e-24 miRNATAP -0.195351613391744 0.000497640625861932 NA NA NA hsa-miR-29c-3p COL4A5 -2.08166260448948 8.3238369390898e-24 2.09669254192623 4.08340113795531e-24 miRNATAP -0.259030194918999 1.74240269957526e-09 NA NA NA hsa-miR-338-5p COL4A5 -1.71946558699173 2.62649071488641e-23 2.09669254192623 4.08340113795531e-24 PITA;miRNATAP -0.171549050426824 0.001025344396586 NA NA NA hsa-miR-29b-3p COL4A6 -0.110721443686039 0.511264554091106 2.3277089689906 1.54878916225774e-09 miRNATAP -0.318336873677959 0.00170141834113974 NA NA NA hsa-miR-29c-3p COL4A6 -2.08166260448948 8.3238369390898e-24 2.3277089689906 1.54878916225774e-09 miRNATAP -0.525713514308252 1.07416710882765e-11 NA NA NA hsa-miR-342-3p COL4A6 0.99756868977753 9.28499866272332e-10 2.3277089689906 1.54878916225774e-09 miRanda -0.333367770641426 0.00122292162583202 NA NA NA hsa-miR-582-3p COL4A6 -0.248056267546012 0.143798829508405 2.3277089689906 1.54878916225774e-09 PITA -0.54700337326178 4.11916730597093e-08 NA NA NA hsa-miR-335-5p COL6A1 -1.17227779671552 1.49282618530733e-10 2.06404004912108 5.05689222523976e-19 miRNAWalker2_validate -0.217929547316827 9.97687424594801e-05 NA NA NA hsa-miR-10b-5p COL6A2 -0.582989331935508 4.56688330655626e-06 1.83065662029131 3.89479005128054e-15 miRNAWalker2_validate -0.302378140664072 0.000208192107867274 NA NA NA hsa-miR-29a-3p COL6A3 -1.26881270980079 2.82496991513463e-22 2.57622836239592 8.76789052806367e-21 MirTarget;miRNATAP -0.447818965900922 9.22881745164829e-07 NA NA NA hsa-miR-29b-3p COL6A3 -0.110721443686039 0.511264554091106 2.57622836239592 8.76789052806367e-21 MirTarget;miRNATAP -0.574756207734078 2.06681631428782e-15 NA NA NA hsa-miR-29c-3p COL6A3 -2.08166260448948 8.3238369390898e-24 2.57622836239592 8.76789052806367e-21 MirTarget;miRNATAP -0.36706530930726 9.84203432236703e-11 NA NA NA hsa-miR-362-3p COL6A3 -0.697212068252854 2.61718493418184e-06 2.57622836239592 8.76789052806367e-21 miRanda -0.441634367480162 1.11407246570406e-07 NA NA NA hsa-miR-429 COL6A3 0.559451508722375 0.00563641638673083 2.57622836239592 8.76789052806367e-21 miRNATAP -0.490897878485218 2.77756213823698e-16 NA NA NA hsa-miR-590-3p COL6A3 0.221436901462551 0.0965904764063157 2.57622836239592 8.76789052806367e-21 miRanda -0.382958054737009 4.4275543696127e-05 NA NA NA hsa-miR-103a-2-5p COL6A6 1.37988337975616 6.74852943995612e-08 -0.297689582719371 0.395680054810934 mirMAP -0.297120327191513 3.22153907883898e-06 NA NA NA hsa-miR-429 COL6A6 0.559451508722375 0.00563641638673083 -0.297689582719371 0.395680054810934 miRanda -0.198170085653646 0.00856831565984871 NA NA NA hsa-miR-576-5p COL6A6 0.940432050128373 6.90227595663302e-12 -0.297689582719371 0.395680054810934 mirMAP -0.391308524060286 0.000337195638510439 NA NA NA hsa-miR-590-5p COL6A6 0.763025362395968 3.65305892505623e-09 -0.297689582719371 0.395680054810934 miRanda -0.501194245322086 1.59457898655918e-05 NA NA NA hsa-miR-944 COL6A6 1.47323925060177 2.61626403984929e-13 -0.297689582719371 0.395680054810934 mirMAP -0.414553379688615 1.43295028042986e-08 NA NA NA hsa-miR-27a-5p COL9A3 0.480723189397622 0.00422876220095238 -0.399600529734866 0.132479815892479 MirTarget -0.180331598761206 0.00878908988900374 NA NA NA hsa-miR-140-5p CREB1 -0.412389003031485 0.000136051708543369 0.0833634892181836 0.210150029095152 miRanda -0.111178354081858 2.87674635694907e-05 NA NA NA hsa-miR-26b-5p CREB1 -0.254478038884324 0.0285227763044636 0.0833634892181836 0.210150029095152 MirTarget;mirMAP -0.112084067832227 6.02971181686137e-06 NA NA NA hsa-miR-30b-5p CREB1 -0.400238605368173 0.00346540992719245 0.0833634892181836 0.210150029095152 MirTarget;mirMAP -0.141218452799686 8.31068761673779e-12 NA NA NA hsa-miR-30c-5p CREB1 0.021222006155897 0.886366656528128 0.0833634892181836 0.210150029095152 MirTarget;mirMAP -0.123938604567463 9.81680809765768e-11 NA NA NA hsa-miR-362-5p CREB1 0.41089772861323 0.0404254902071382 0.0833634892181836 0.210150029095152 TargetScan -0.109972966997688 3.83737186201929e-15 NA NA NA hsa-miR-374a-3p CREB1 -0.299190081500425 0.00682975596757891 0.0833634892181836 0.210150029095152 mirMAP -0.119250473722041 4.53804189231396e-06 NA NA NA hsa-miR-374b-5p CREB1 -0.288413933608091 0.0041474558664058 0.0833634892181836 0.210150029095152 mirMAP -0.192540323320925 1.0256241932352e-11 NA NA NA hsa-miR-664a-3p CREB1 -0.256108763664991 0.0513188660751664 0.0833634892181836 0.210150029095152 mirMAP -0.1478089270742 7.62549569686349e-12 NA NA NA hsa-let-7d-5p CREB3L2 0.481757661442508 3.66030810124939e-07 -0.271141217119928 0.0350916204915881 mirMAP -0.267617589957382 5.35790666128689e-06 NA NA NA hsa-miR-106a-5p CREB3L2 0.67978010057847 0.00221925869726092 -0.271141217119928 0.0350916204915881 mirMAP -0.110339014198738 1.00981611149023e-05 NA NA NA hsa-miR-106b-5p CREB3L2 0.50378717276868 1.45412404526866e-05 -0.271141217119928 0.0350916204915881 mirMAP -0.218741148464824 4.89734926741099e-06 NA NA NA hsa-miR-141-3p CREB3L2 0.730011517758706 0.000120338355004032 -0.271141217119928 0.0350916204915881 MirTarget -0.215237262731005 6.42297011050032e-14 NA NA NA hsa-miR-146b-5p CREB3L2 0.917975986853978 3.33749259316025e-09 -0.271141217119928 0.0350916204915881 miRanda;mirMAP -0.183965260141888 1.89093279019249e-07 NA NA NA hsa-miR-16-2-3p CREB3L2 1.1567130855258 1.01867256952189e-14 -0.271141217119928 0.0350916204915881 mirMAP -0.336866431976439 9.67110978139277e-22 NA NA NA hsa-miR-16-5p CREB3L2 0.521122945828175 1.40561786410572e-06 -0.271141217119928 0.0350916204915881 miRNAWalker2_validate -0.266203771420885 2.13122087394858e-07 NA NA NA hsa-miR-17-5p CREB3L2 1.41924888736771 2.75805544953758e-18 -0.271141217119928 0.0350916204915881 mirMAP -0.296383853182551 2.86158585917623e-20 NA NA NA hsa-miR-181b-5p CREB3L2 0.974255518824355 2.64876280203475e-16 -0.271141217119928 0.0350916204915881 mirMAP -0.135480285275103 0.00318709034633111 NA NA NA hsa-miR-186-5p CREB3L2 0.353452958261612 0.000145058448579496 -0.271141217119928 0.0350916204915881 MirTarget -0.318681061725447 1.10795673755907e-07 NA NA NA hsa-miR-18a-3p CREB3L2 1.82583720936229 7.51297960972179e-19 -0.271141217119928 0.0350916204915881 MirTarget -0.172609429857194 7.91488021904338e-11 NA NA NA hsa-miR-1976 CREB3L2 0.638808083289405 2.94840228896364e-07 -0.271141217119928 0.0350916204915881 MirTarget -0.187775876224769 2.44148081301048e-05 NA NA NA hsa-miR-19b-3p CREB3L2 0.538732279378089 0.000622008277870679 -0.271141217119928 0.0350916204915881 miRNAWalker2_validate -0.354426560067166 1.22369932435494e-25 NA NA NA hsa-miR-200a-3p CREB3L2 0.607140814457753 0.00289840524858752 -0.271141217119928 0.0350916204915881 MirTarget -0.215165888663547 7.34696600445406e-16 NA NA NA hsa-miR-205-3p CREB3L2 1.2960640797621 5.80786479909147e-11 -0.271141217119928 0.0350916204915881 mirMAP -0.195610931348261 6.63520293615741e-13 NA NA NA hsa-miR-20a-5p CREB3L2 1.1531986665452 1.02385132917958e-11 -0.271141217119928 0.0350916204915881 mirMAP -0.315613096985859 2.42473528330655e-24 NA NA NA hsa-miR-2355-3p CREB3L2 1.58434563546762 4.06578912176206e-18 -0.271141217119928 0.0350916204915881 mirMAP -0.106372287743268 0.000328099586860481 NA NA NA hsa-miR-2355-5p CREB3L2 1.47205546931107 8.65192179636668e-19 -0.271141217119928 0.0350916204915881 MirTarget -0.145541602846885 6.95226496521831e-06 NA NA NA hsa-miR-25-3p CREB3L2 0.76549796417801 3.32282098247097e-11 -0.271141217119928 0.0350916204915881 MirTarget;miRNATAP -0.339761408161708 4.41189489982582e-13 NA NA NA hsa-miR-29b-1-5p CREB3L2 1.39669186711325 4.36960953138935e-11 -0.271141217119928 0.0350916204915881 mirMAP -0.170128744614202 2.72709617822882e-11 NA NA NA hsa-miR-29b-2-5p CREB3L2 -0.502720326849742 0.000730448246894952 -0.271141217119928 0.0350916204915881 mirMAP -0.147968538668065 7.8345865107691e-05 NA NA NA hsa-miR-32-5p CREB3L2 -0.317310201890053 0.0102525324475293 -0.271141217119928 0.0350916204915881 MirTarget;miRNATAP -0.206564420621531 4.9275548559019e-06 NA NA NA hsa-miR-362-5p CREB3L2 0.41089772861323 0.0404254902071382 -0.271141217119928 0.0350916204915881 mirMAP -0.246469401614843 6.02436141546449e-20 NA NA NA hsa-miR-374b-5p CREB3L2 -0.288413933608091 0.0041474558664058 -0.271141217119928 0.0350916204915881 mirMAP -0.246598276244982 9.86428737439978e-06 NA NA NA hsa-miR-429 CREB3L2 0.559451508722375 0.00563641638673083 -0.271141217119928 0.0350916204915881 miRNATAP -0.180212531980411 3.45273083139505e-11 NA NA NA hsa-miR-501-5p CREB3L2 1.02806906860218 1.63456814370548e-09 -0.271141217119928 0.0350916204915881 mirMAP -0.186929798978841 8.35744728545612e-09 NA NA NA hsa-miR-590-3p CREB3L2 0.221436901462551 0.0965904764063157 -0.271141217119928 0.0350916204915881 miRanda;miRNATAP -0.175031387414718 3.13491853544304e-05 NA NA NA hsa-miR-671-5p CREB3L2 1.90920358947989 6.8158317757852e-31 -0.271141217119928 0.0350916204915881 MirTarget -0.165740218852093 1.66063545297766e-07 NA NA NA hsa-miR-7-1-3p CREB3L2 1.13646121619622 1.49823237535933e-14 -0.271141217119928 0.0350916204915881 mirMAP -0.255377389561279 1.96222448744689e-12 NA NA NA hsa-miR-92a-1-5p CREB3L2 1.41314158431819 2.67965667765933e-11 -0.271141217119928 0.0350916204915881 MirTarget -0.249167865228589 1.28662190018179e-23 NA NA NA hsa-miR-92a-3p CREB3L2 0.994679542307232 1.32587679156217e-16 -0.271141217119928 0.0350916204915881 miRNAWalker2_validate;MirTarget;miRNATAP -0.374647618650866 1.87102879653103e-17 NA NA NA hsa-miR-106a-5p CREB5 0.67978010057847 0.00221925869726092 -0.0622124382278488 0.779123556495118 MirTarget;miRNATAP -0.246594409032704 8.10636265748701e-09 NA NA NA hsa-miR-141-3p CREB5 0.730011517758706 0.000120338355004032 -0.0622124382278488 0.779123556495118 mirMAP -0.270933024656731 6.26578645822296e-08 NA NA NA hsa-miR-142-3p CREB5 1.12754191614028 1.68798138028946e-08 -0.0622124382278488 0.779123556495118 miRNATAP -0.17295161819055 0.000273073698895741 NA NA NA hsa-miR-15a-5p CREB5 0.783550182002274 2.60699595655907e-11 -0.0622124382278488 0.779123556495118 miRNATAP -0.351252888011221 1.31011343239809e-05 NA NA NA hsa-miR-15b-5p CREB5 0.85315666454713 3.79816274836297e-12 -0.0622124382278488 0.779123556495118 miRNATAP -0.251342129504508 0.00113213000879034 NA NA NA hsa-miR-16-2-3p CREB5 1.1567130855258 1.01867256952189e-14 -0.0622124382278488 0.779123556495118 mirMAP -0.267701187432022 1.958119369564e-05 NA NA NA hsa-miR-16-5p CREB5 0.521122945828175 1.40561786410572e-06 -0.0622124382278488 0.779123556495118 miRNATAP -0.257929869703282 0.00382233647877738 NA NA NA hsa-miR-17-5p CREB5 1.41924888736771 2.75805544953758e-18 -0.0622124382278488 0.779123556495118 MirTarget;TargetScan;miRNATAP -0.217528469999021 0.000143748065927672 NA NA NA hsa-miR-19a-3p CREB5 1.35800152353624 2.80940447111944e-12 -0.0622124382278488 0.779123556495118 mirMAP -0.199504050317685 3.75564129180557e-05 NA NA NA hsa-miR-19b-3p CREB5 0.538732279378089 0.000622008277870679 -0.0622124382278488 0.779123556495118 mirMAP -0.276299533223944 5.52718202859554e-06 NA NA NA hsa-miR-200a-3p CREB5 0.607140814457753 0.00289840524858752 -0.0622124382278488 0.779123556495118 mirMAP -0.282229951927395 1.36103726698795e-09 NA NA NA hsa-miR-200b-3p CREB5 0.0717138787925347 0.682858087587209 -0.0622124382278488 0.779123556495118 TargetScan -0.324440035622686 2.46539262435445e-09 NA NA NA hsa-miR-200c-3p CREB5 0.630251054099546 0.000131975031451555 -0.0622124382278488 0.779123556495118 miRNATAP -0.256951501927802 9.38264007890872e-06 NA NA NA hsa-miR-20a-5p CREB5 1.1531986665452 1.02385132917958e-11 -0.0622124382278488 0.779123556495118 MirTarget;miRNATAP -0.261123214871147 2.52110324703726e-06 NA NA NA hsa-miR-20b-5p CREB5 0.345967670847176 0.232014828043601 -0.0622124382278488 0.779123556495118 MirTarget;miRNATAP -0.199185436741341 1.40777605577776e-09 NA NA NA hsa-miR-26b-3p CREB5 0.421575313079363 0.00223298166810883 -0.0622124382278488 0.779123556495118 MirTarget -0.185082597800233 0.00826097652491109 NA NA NA hsa-miR-29b-3p CREB5 -0.110721443686039 0.511264554091106 -0.0622124382278488 0.779123556495118 MirTarget;miRNATAP -0.210480533282757 0.000237104361336078 NA NA NA hsa-miR-30b-3p CREB5 -0.338530747940815 0.0223424741180399 -0.0622124382278488 0.779123556495118 MirTarget -0.198680350859329 0.0023603559642065 NA NA NA hsa-miR-34a-5p CREB5 -0.117372471043915 0.364001947180738 -0.0622124382278488 0.779123556495118 miRNATAP -0.26162376298661 0.000479353719352826 NA NA NA hsa-miR-3607-3p CREB5 1.01377165357363 9.13355519701165e-05 -0.0622124382278488 0.779123556495118 mirMAP -0.100903052269319 0.00644211001016315 NA NA NA hsa-miR-362-5p CREB5 0.41089772861323 0.0404254902071382 -0.0622124382278488 0.779123556495118 PITA -0.213589499894473 8.02721963516431e-06 NA NA NA hsa-miR-429 CREB5 0.559451508722375 0.00563641638673083 -0.0622124382278488 0.779123556495118 PITA;miRanda;miRNATAP -0.245658970119584 1.9699435486279e-07 NA NA NA hsa-miR-454-3p CREB5 1.54137391927201 4.15861570449376e-20 -0.0622124382278488 0.779123556495118 miRNATAP -0.201367170622891 0.000270173559774119 NA NA NA hsa-miR-532-3p CREB5 0.80240056676907 1.08989551712617e-09 -0.0622124382278488 0.779123556495118 miRNATAP -0.217134968687798 0.00271297004367782 NA NA NA hsa-miR-582-3p CREB5 -0.248056267546012 0.143798829508405 -0.0622124382278488 0.779123556495118 MirTarget;PITA;miRNATAP -0.17745415892993 0.00182722959168248 NA NA NA hsa-miR-590-5p CREB5 0.763025362395968 3.65305892505623e-09 -0.0622124382278488 0.779123556495118 miRNATAP -0.205518514085438 0.00538236681372144 NA NA NA hsa-miR-7-1-3p CREB5 1.13646121619622 1.49823237535933e-14 -0.0622124382278488 0.779123556495118 mirMAP -0.207201014092825 0.00113731238853466 NA NA NA hsa-miR-9-5p CREB5 1.65694862043766 2.08325802567323e-05 -0.0622124382278488 0.779123556495118 miRNATAP -0.148253821668212 9.22760236616224e-10 NA NA NA hsa-miR-93-5p CREB5 1.61042951896619 5.1280369606967e-24 -0.0622124382278488 0.779123556495118 MirTarget;miRNATAP -0.23584917318052 4.34334690290381e-05 NA NA NA hsa-miR-106b-5p CSF1 0.50378717276868 1.45412404526866e-05 -0.395344296512344 0.0366179306088304 miRNATAP -0.213141559996663 0.00262457932581044 NA NA NA hsa-miR-125a-5p CSF1 0.215366061934933 0.119550904549401 -0.395344296512344 0.0366179306088304 mirMAP -0.162177183821337 0.00673489115062628 NA NA NA hsa-miR-130a-3p CSF1 0.67051191119964 4.89747518735144e-06 -0.395344296512344 0.0366179306088304 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.338819425385429 7.70001056624161e-10 18823650 Finally downstream target validation was proven for the miR-130a whose downregulation was linked to the translational activation of the M-CSF gene a known resistance factor for ovarian cancer drug resistance ovarian cancer hsa-miR-130b-3p CSF1 1.44628430084411 9.13980959861273e-24 -0.395344296512344 0.0366179306088304 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.262150708520788 1.49996229073617e-06 22005523 CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system; CSF-1 expression was negatively associated with miR-130b level in ovarian tissues and cell lines; Luciferase assay validated CSF-1 is a direct target of miR-130b; Knock-down of CSF-1 sensitized ovarian cancer cells to anticancer drugs and could partially attenuate the resistance inducing effect of miR-130b inhibitors; Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1 and the silencing of miR-130b may be mediated by DNA methylation drug resistance ovarian cancer hsa-miR-149-5p CSF1 0.443278770827687 0.0642022866136881 -0.395344296512344 0.0366179306088304 MirTarget -0.346860531103734 3.22776460234644e-26 NA NA NA hsa-miR-15a-5p CSF1 0.783550182002274 2.60699595655907e-11 -0.395344296512344 0.0366179306088304 miRNATAP -0.338761477235692 8.10890401435535e-07 NA NA NA hsa-miR-17-5p CSF1 1.41924888736771 2.75805544953758e-18 -0.395344296512344 0.0366179306088304 TargetScan;miRNATAP -0.479743735078695 1.30867254370933e-24 NA NA NA hsa-miR-197-3p CSF1 0.878693269130833 3.84847526014135e-15 -0.395344296512344 0.0366179306088304 MirTarget -0.291321943129489 5.13467155279589e-05 NA NA NA hsa-miR-205-5p CSF1 1.50759485376634 2.0003886738248e-16 -0.395344296512344 0.0366179306088304 MirTarget -0.371318300807809 1.49636449226668e-18 NA NA NA hsa-miR-20a-5p CSF1 1.1531986665452 1.02385132917958e-11 -0.395344296512344 0.0366179306088304 miRNATAP -0.455232782593005 2.31942812972796e-23 NA NA NA hsa-miR-23a-5p CSF1 1.662156284689 7.34844237202118e-15 -0.395344296512344 0.0366179306088304 MirTarget -0.163568116201254 1.58835594610855e-05 NA NA NA hsa-miR-27a-3p CSF1 0.348456440505425 0.00126682892514312 -0.395344296512344 0.0366179306088304 MirTarget;miRNATAP -0.286646955208082 0.000175122490939345 NA NA NA hsa-miR-27b-3p CSF1 -0.732682718863563 2.26896143573324e-09 -0.395344296512344 0.0366179306088304 MirTarget;miRNATAP -0.183831160959538 0.00577489813734823 NA NA NA hsa-miR-301a-3p CSF1 2.14132004241926 4.46255413526808e-25 -0.395344296512344 0.0366179306088304 MirTarget;miRNATAP -0.290406683339765 4.06439220558199e-15 NA NA NA hsa-miR-30b-5p CSF1 -0.400238605368173 0.00346540992719245 -0.395344296512344 0.0366179306088304 miRNAWalker2_validate -0.291306091269383 1.12618459192728e-06 NA NA NA hsa-miR-30c-5p CSF1 0.021222006155897 0.886366656528128 -0.395344296512344 0.0366179306088304 miRNAWalker2_validate -0.294764158216072 9.36341876918087e-08 NA NA NA hsa-miR-429 CSF1 0.559451508722375 0.00563641638673083 -0.395344296512344 0.0366179306088304 PITA;miRanda;miRNATAP -0.412211261861765 1.97214914555001e-26 NA NA NA hsa-miR-454-3p CSF1 1.54137391927201 4.15861570449376e-20 -0.395344296512344 0.0366179306088304 MirTarget;miRNATAP -0.294100408482872 2.86733710923803e-10 NA NA NA hsa-miR-505-3p CSF1 0.912823669571645 4.0549774967148e-13 -0.395344296512344 0.0366179306088304 miRNAWalker2_validate -0.285574950736628 7.9792173361443e-06 NA NA NA hsa-miR-532-3p CSF1 0.80240056676907 1.08989551712617e-09 -0.395344296512344 0.0366179306088304 MirTarget;PITA -0.324635622209122 1.18763671452161e-07 NA NA NA hsa-miR-532-5p CSF1 -0.021857649390892 0.830992272120134 -0.395344296512344 0.0366179306088304 miRNATAP -0.451253318869355 2.05420161227854e-08 NA NA NA hsa-miR-708-5p CSF1 1.54207894190626 2.2887257992285e-19 -0.395344296512344 0.0366179306088304 miRNATAP -0.29285378224165 1.4910271560831e-10 NA NA NA hsa-miR-93-5p CSF1 1.61042951896619 5.1280369606967e-24 -0.395344296512344 0.0366179306088304 miRNATAP -0.421825156681646 1.26406597070088e-18 NA NA NA hsa-miR-940 CSF1 1.25303020594374 1.3005368359451e-10 -0.395344296512344 0.0366179306088304 MirTarget;PITA;miRNATAP -0.164486429826726 8.71705336652414e-05 NA NA NA hsa-miR-96-5p CSF1 1.42326703011157 4.39736150032373e-14 -0.395344296512344 0.0366179306088304 miRNATAP -0.451408210420024 5.06847835877813e-29 NA NA NA hsa-miR-339-5p CSF1R 1.07771430326938 2.45772601859307e-09 -0.158717133634124 0.439054074137574 miRanda -0.325967760517482 9.12881252755359e-12 NA NA NA hsa-miR-34c-5p CSF1R 0.565896455062849 0.0224052732281715 -0.158717133634124 0.439054074137574 MirTarget;miRanda;miRNATAP -0.139899378360785 9.55471978270924e-05 NA NA NA hsa-miR-361-5p CSF3R 0.0803683277369505 0.314043140368058 0.718899439132889 0.00193557981840307 miRanda -0.503779960182056 9.28501921314817e-05 NA NA NA hsa-miR-429 CSF3R 0.559451508722375 0.00563641638673083 0.718899439132889 0.00193557981840307 miRanda -0.195207618122359 9.08134219311384e-05 NA NA NA hsa-miR-101-3p DDIT4 -1.91263766544878 1.50270129259053e-39 0.970744345695446 1.21158401060779e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.342380259239773 5.91047029457662e-10 NA NA NA hsa-miR-139-5p DDIT4 -1.46099200329485 7.85040381494472e-22 0.970744345695446 1.21158401060779e-06 MirTarget;miRanda;miRNATAP -0.327281605694535 2.42764419386966e-09 NA NA NA hsa-miR-181c-5p DDIT4 -0.168991199007857 0.196949106150297 0.970744345695446 1.21158401060779e-06 MirTarget -0.257540521853273 0.000130092784283203 NA NA NA hsa-miR-217 DDIT4 -1.35391381055929 2.42394951427902e-09 0.970744345695446 1.21158401060779e-06 miRanda -0.153215259980346 5.55175086608736e-05 NA NA NA hsa-miR-30a-5p DDIT4 -1.79779915425811 1.93360169837799e-26 0.970744345695446 1.21158401060779e-06 MirTarget;miRNATAP -0.154401827902412 0.00180557215482945 NA NA NA hsa-miR-30e-5p DDIT4 -1.02114836019762 6.81961221797866e-17 0.970744345695446 1.21158401060779e-06 MirTarget -0.379303698849891 4.53009508603041e-08 NA NA NA hsa-miR-30c-2-3p EFNA1 -1.82791447399693 2.41509888037865e-21 0.457367123980915 0.000509296121229094 MirTarget -0.166775455540874 3.79223687167938e-09 NA NA NA hsa-miR-326 EFNA1 -0.425943992128769 0.0415010315530797 0.457367123980915 0.000509296121229094 miRanda -0.145744922348379 9.95109469024053e-08 NA NA NA hsa-miR-486-5p EFNA1 -1.70341092285685 6.64232609099498e-14 0.457367123980915 0.000509296121229094 miRanda -0.109691489140236 7.72682845452763e-06 NA NA NA hsa-miR-2110 EFNA3 -0.097378294887309 0.534549425629295 -0.111220394827782 0.566844855883492 miRNATAP -0.206476937571905 0.000198360023193457 NA NA NA hsa-miR-30a-5p EFNA3 -1.79779915425811 1.93360169837799e-26 -0.111220394827782 0.566844855883492 MirTarget;mirMAP;miRNATAP -0.197379638816703 3.05633349594278e-05 NA NA NA hsa-miR-30d-5p EFNA3 -0.38399848121878 0.000171129616944749 -0.111220394827782 0.566844855883492 MirTarget;mirMAP;miRNATAP -0.224956414341343 0.00675214826558602 NA NA NA hsa-miR-30e-5p EFNA3 -1.02114836019762 6.81961221797866e-17 -0.111220394827782 0.566844855883492 MirTarget;mirMAP -0.321139349547888 1.53887283953078e-06 NA NA NA hsa-miR-326 EFNA3 -0.425943992128769 0.0415010315530797 -0.111220394827782 0.566844855883492 MirTarget;miRanda;miRNATAP -0.204598953828051 3.67018388138734e-07 NA NA NA hsa-miR-330-3p EFNA3 -0.0524949332825773 0.719856123539461 -0.111220394827782 0.566844855883492 PITA;miRNATAP -0.165081158771636 0.00444695403014315 NA NA NA hsa-miR-330-5p EFNA3 0.944693925383906 5.04972895657346e-13 -0.111220394827782 0.566844855883492 MirTarget;miRanda;miRNATAP -0.217813234348746 0.000577123937543295 NA NA NA hsa-miR-342-5p EFNA3 0.862385578881784 1.60007936373305e-08 -0.111220394827782 0.566844855883492 miRNATAP -0.183275894973583 0.000797872924763551 NA NA NA hsa-miR-361-3p EFNA3 0.272298288982435 0.0147874880476998 -0.111220394827782 0.566844855883492 MirTarget;miRNATAP -0.400801837123043 1.0410817796917e-07 NA NA NA hsa-miR-423-5p EFNA3 0.60141781325829 1.62940950644999e-07 -0.111220394827782 0.566844855883492 MirTarget;PITA;miRNATAP -0.36640935128474 4.49153292025969e-07 NA NA NA hsa-miR-491-5p EFNA3 -0.541680329196715 0.00135829217561865 -0.111220394827782 0.566844855883492 PITA;miRanda;miRNATAP -0.182445268929087 0.000463080296519282 NA NA NA hsa-miR-103a-2-5p EFNA5 1.37988337975616 6.74852943995612e-08 -1.22199137148167 6.86022378355376e-09 MirTarget -0.129179480031755 0.000978956647827604 NA NA NA hsa-miR-15b-3p EFNA5 1.05020782493504 6.38723677324836e-14 -1.22199137148167 6.86022378355376e-09 mirMAP -0.252313213888087 0.000101657831620038 NA NA NA hsa-miR-186-5p EFNA5 0.353452958261612 0.000145058448579496 -1.22199137148167 6.86022378355376e-09 mirMAP -0.292828668890667 0.00368270694047647 NA NA NA hsa-miR-19a-3p EFNA5 1.35800152353624 2.80940447111944e-12 -1.22199137148167 6.86022378355376e-09 miRNATAP -0.173259760034209 0.000215458020093004 NA NA NA hsa-miR-200c-3p EFNA5 0.630251054099546 0.000131975031451555 -1.22199137148167 6.86022378355376e-09 miRNATAP -0.153866238298602 0.00631541570613121 NA NA NA hsa-miR-20a-3p EFNA5 1.34885093664027 2.07697464119202e-12 -1.22199137148167 6.86022378355376e-09 mirMAP -0.144555053766916 0.00234983429033761 NA NA NA hsa-miR-21-3p EFNA5 1.25126438776674 2.4124216716282e-17 -1.22199137148167 6.86022378355376e-09 mirMAP -0.212067504812099 0.00052479558203858 NA NA NA hsa-miR-29b-3p EFNA5 -0.110721443686039 0.511264554091106 -1.22199137148167 6.86022378355376e-09 miRNATAP -0.211686837406341 0.000128497934345782 NA NA NA hsa-miR-335-3p EFNA5 0.336785882180547 0.0542446207938138 -1.22199137148167 6.86022378355376e-09 mirMAP -0.150919557175587 0.00465235729404315 NA NA NA hsa-miR-342-3p EFNA5 0.99756868977753 9.28499866272332e-10 -1.22199137148167 6.86022378355376e-09 miRNATAP -0.159591124129106 0.00464216956209919 NA NA NA hsa-miR-421 EFNA5 0.945488088619653 2.35762398527362e-09 -1.22199137148167 6.86022378355376e-09 mirMAP -0.160644495427995 0.00584038318557551 NA NA NA hsa-miR-429 EFNA5 0.559451508722375 0.00563641638673083 -1.22199137148167 6.86022378355376e-09 miRNATAP -0.122314534852078 0.00790652775501798 NA NA NA hsa-miR-450b-5p EFNA5 1.25529820885833 1.18847120528666e-15 -1.22199137148167 6.86022378355376e-09 mirMAP -0.166416099398179 0.00403604528451531 NA NA NA hsa-miR-501-5p EFNA5 1.02806906860218 1.63456814370548e-09 -1.22199137148167 6.86022378355376e-09 mirMAP -0.167180585616505 0.00219909263230495 NA NA NA hsa-miR-590-3p EFNA5 0.221436901462551 0.0965904764063157 -1.22199137148167 6.86022378355376e-09 miRanda;mirMAP -0.245530633460186 0.000461995983518845 NA NA NA hsa-miR-7-1-3p EFNA5 1.13646121619622 1.49823237535933e-14 -1.22199137148167 6.86022378355376e-09 mirMAP -0.312382585886428 3.10545686694962e-07 NA NA NA hsa-miR-92a-3p EFNA5 0.994679542307232 1.32587679156217e-16 -1.22199137148167 6.86022378355376e-09 miRNAWalker2_validate -0.252250236327487 0.00083049459351438 NA NA NA hsa-miR-944 EFNA5 1.47323925060177 2.61626403984929e-13 -1.22199137148167 6.86022378355376e-09 mirMAP -0.124709385029952 0.0057940911309002 NA NA NA hsa-miR-96-5p EFNA5 1.42326703011157 4.39736150032373e-14 -1.22199137148167 6.86022378355376e-09 TargetScan -0.163995701344485 0.00065815164886802 NA NA NA hsa-miR-590-3p EGF 0.221436901462551 0.0965904764063157 -2.10075991194281 5.08275628156253e-09 miRanda -0.330881763767121 0.00576591126865384 NA NA NA hsa-miR-629-3p EGF 1.43262037314105 2.37092217984413e-19 -2.10075991194281 5.08275628156253e-09 miRNATAP -0.795198092528241 2.00645853141744e-17 NA NA NA hsa-miR-125a-5p EGFR 0.215366061934933 0.119550904549401 0.421988255273135 0.0732089026211386 mirMAP -0.438449046612586 2.45858610383153e-09 19881956;27094723;24484870 We report that EGFR signaling leads to transcriptional repression of the miRNA miR-125a through the ETS family transcription factor PEA3;Suppression of microRNA 125a 5p upregulates the TAZ EGFR signaling pathway and promotes retinoblastoma proliferation; Moreover the overexpression of miR-125a-5p led to a decrease in TAZ expression and downstream EGFR signaling pathway activation both in vitro and vivo; Finally TAZ overexpression in retinoblastoma cells overexpressing miR-125a-5p restored retinoblastoma cell proliferation and EGFR pathway activation; Taken together our data demonstrated that miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma;miR 125a regulates cell cycle proliferation and apoptosis by targeting the ErbB pathway in acute myeloid leukemia; Profiling revealed the ErbB pathway as significantly decreased with ectopic miR-125a; Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic agents for treating miR-125a-low AML ;progression;progression ovarian cancer;retinoblastoma;acute myeloid leukemia hsa-miR-140-5p EGFR -0.412389003031485 0.000136051708543369 0.421988255273135 0.0732089026211386 miRanda -0.396347951906697 2.8829446407085e-05 NA NA NA hsa-miR-141-3p EGFR 0.730011517758706 0.000120338355004032 0.421988255273135 0.0732089026211386 MirTarget -0.172797280203478 0.00130092154204067 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-142-3p EGFR 1.12754191614028 1.68798138028946e-08 0.421988255273135 0.0732089026211386 miRanda -0.211213785673619 2.81655424599246e-05 NA NA NA hsa-miR-146a-5p EGFR -0.0201236699646614 0.905882759106561 0.421988255273135 0.0732089026211386 miRNAWalker2_validate -0.160035522858436 0.00817015681506167 25242818;22161865;25596948;24895573;25417703;23555954;24839931;21632853 Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;MiR 146a suppresses tumor growth and progression by targeting EGFR pathway and in a p ERK dependent manner in castration resistant prostate cancer; Mechanistic studies revealed that miR-146a repressed the expression of EGFR through binding to its 3'-untranslated region; Our findings suggest that ubiquitous loss of miR-146a is a critical mechanism for overexpression of EGFR in CRPC which is crucial to better understanding the pathogenesis of CRPC;Furthermore the expressions of bax and cleaved-caspase-3 mainly were increased in control and overexpression miR-146a groups however the expression of EGFR was inverse; All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells which was performed by up-regulating miR-146a expression then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways and inhibiting invasion through down-regulating the expression of EGFR;Furthermore western blot showed that miR-146a mimic downregulated EGFR ERK1/2 and stat5 signalings; These effects were less potent compared to that of a siRNA targeting EGFR a known target gene of miR-146a; Moreover miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents;Here we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a; We show that BRCA1 binds to MIR146A promoter and activates transcription which in turn attenuates EGFR expression;In functional experiments miR-146a suppressed cell growth induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines H358 H1650 H1975 HCC827 and H292 miR-146a also inhibited the migratory capacity of these NSCLC cells; On the other hand miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR including both TKIs gefitinib erlotinib and afatinib and a monoclonal antibody cetuximab; Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling;Deregulation of miR 146a expression in a mouse model of pancreatic cancer affecting EGFR signaling; Treatment of PC cells with CDF a novel synthetic compound led to re-expression of miR-146a resulting in the down-regulation of EGFR expression; Further knock-down of miR-146a in AsPC-1 cells led to the up-regulation of EGFR expression and showed increased clonogenic growth; In addition knock-down of EGFR by EGFR siRNA transfection of parental AsPC-1 cells and AsPC-1 cells stably transfected with pre-miR-146a resulted in decreased invasive capacity which was further confirmed by reduced luciferase activity in cells transfected with pMIR-Luc reporter vector containing miR-146a binding site; Collectively these results suggest that the loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling and that re-expression of miR-146a by CDF treatment could be useful in designing personalized strategy for the treatment of human PC;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;progression;;;;;; pancreatic cancer;prostate cancer;breast cancer;liver cancer;breast cancer;lung squamous cell cancer;pancreatic cancer;gastric cancer hsa-miR-146b-5p EGFR 0.917975986853978 3.33749259316025e-09 0.421988255273135 0.0732089026211386 miRNATAP -0.204870248909093 0.00168265901828329 NA NA NA hsa-miR-148b-5p EGFR 1.1533193737265 7.26420964688337e-13 0.421988255273135 0.0732089026211386 mirMAP -0.286420865380633 5.32215159627121e-06 NA NA NA hsa-miR-155-5p EGFR 0.533437622040649 0.00248671179205372 0.421988255273135 0.0732089026211386 miRNAWalker2_validate;MirTarget -0.315457381088104 4.08354886790646e-08 NA NA NA hsa-miR-16-2-3p EGFR 1.1567130855258 1.01867256952189e-14 0.421988255273135 0.0732089026211386 mirMAP -0.358641825525018 6.42478479617906e-08 NA NA NA hsa-miR-16-5p EGFR 0.521122945828175 1.40561786410572e-06 0.421988255273135 0.0732089026211386 miRNAWalker2_validate -0.328580412453127 0.000519061828104517 NA NA NA hsa-miR-17-5p EGFR 1.41924888736771 2.75805544953758e-18 0.421988255273135 0.0732089026211386 TargetScan -0.226636907400546 0.000196756202717447 NA NA NA hsa-miR-186-5p EGFR 0.353452958261612 0.000145058448579496 0.421988255273135 0.0732089026211386 mirMAP -0.576889529374807 1.57349391573345e-07 NA NA NA hsa-miR-188-5p EGFR 0.559328953885106 0.000430338888594543 0.421988255273135 0.0732089026211386 mirMAP -0.24946956675347 0.000110017792853201 NA NA NA hsa-miR-192-5p EGFR 0.380924502586635 0.00986961967409205 0.421988255273135 0.0732089026211386 mirMAP -0.285652307836721 3.76566486689093e-05 NA NA NA hsa-miR-194-3p EGFR 0.735945243226384 8.65425299041628e-05 0.421988255273135 0.0732089026211386 MirTarget -0.203346613744587 0.000253896402950562 NA NA NA hsa-miR-195-3p EGFR -0.624259620429699 0.000164279659144497 0.421988255273135 0.0732089026211386 mirMAP -0.19497730351888 0.00166149772991568 24282590 Plasma levels of miR-195 and miR-122 expression were also associated with overall survival in the patients especially in those with advanced stage HR=0.23 95%CI:0.07-0.84; and HR=0.22 95%CI:0.06-0.77 and EGFR mutation HR=0.27 95%CI:0.08-0.96; and HR=0.23 95%CI=0.06-0.81; Circulating miR-195 and miR-122 may have prognostic values in predicting the overall survival as well as predicting EGFR mutation status in non-smoking female patients with lung adenocarcinoma; Measuring plasma levels of miR-195 and miR-122 may especially be useful in EGFR mutant patients with lung adenocarcinoma staging;poor survival lung cancer hsa-miR-19b-1-5p EGFR 0.757034032029085 2.99828133413343e-07 0.421988255273135 0.0732089026211386 MirTarget;mirMAP -0.264619317805959 0.000116525502311464 NA NA NA hsa-miR-200a-3p EGFR 0.607140814457753 0.00289840524858752 0.421988255273135 0.0732089026211386 MirTarget -0.185851016039293 0.0002060718259245 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-29a-5p EGFR 0.323252792625584 0.0370417231222825 0.421988255273135 0.0732089026211386 mirMAP -0.315796770084768 1.62274156486412e-06 27477273 Feedback Loop Regulation of SCAP/SREBP 1 by miR 29 Modulates EGFR Signaling Driven Glioblastoma Growth glioblastoma hsa-miR-29b-1-5p EGFR 1.39669186711325 4.36960953138935e-11 0.421988255273135 0.0732089026211386 mirMAP -0.139979215565319 0.00326868198559164 NA NA NA hsa-miR-29b-2-5p EGFR -0.502720326849742 0.000730448246894952 0.421988255273135 0.0732089026211386 mirMAP -0.497369532233757 1.56245540377723e-13 NA NA NA hsa-miR-30a-5p EGFR -1.79779915425811 1.93360169837799e-26 0.421988255273135 0.0732089026211386 miRNAWalker2_validate -0.306757641684714 8.20602294984162e-08 NA NA NA hsa-miR-30d-3p EGFR -0.577371911152798 2.02950840095287e-06 0.421988255273135 0.0732089026211386 mirMAP -0.55614047964665 1.90273921147636e-11 NA NA NA hsa-miR-320a EGFR 0.801356001806321 4.91397101474502e-09 0.421988255273135 0.0732089026211386 miRanda;mirMAP -0.4112815999507 1.99503458536141e-08 NA NA NA hsa-miR-339-5p EGFR 1.07771430326938 2.45772601859307e-09 0.421988255273135 0.0732089026211386 miRanda -0.301182089829907 5.46692321863833e-08 NA NA NA hsa-miR-342-3p EGFR 0.99756868977753 9.28499866272332e-10 0.421988255273135 0.0732089026211386 miRanda -0.470164440540375 8.18136541285207e-15 NA NA NA hsa-miR-362-5p EGFR 0.41089772861323 0.0404254902071382 0.421988255273135 0.0732089026211386 mirMAP -0.490166529371809 1.47272058402061e-23 NA NA NA hsa-miR-374a-3p EGFR -0.299190081500425 0.00682975596757891 0.421988255273135 0.0732089026211386 mirMAP -0.471337447459554 3.48991327357632e-07 NA NA NA hsa-miR-491-5p EGFR -0.541680329196715 0.00135829217561865 0.421988255273135 0.0732089026211386 miRanda -0.223393265101076 0.000416870423604875 25299770 This latter effect is due to direct targeting of epidermal growth factor receptor EGFR by miR-491-5p and consequent inhibition of downstream AKT and MAPK signalling pathways; Induction of apoptosis by miR-491-5p in this cell line is mimicked by a combination of EGFR inhibition together with a BH3-mimetic molecule ovarian cancer hsa-miR-501-5p EGFR 1.02806906860218 1.63456814370548e-09 0.421988255273135 0.0732089026211386 mirMAP -0.286508470352779 1.61039937416558e-06 NA NA NA hsa-miR-590-3p EGFR 0.221436901462551 0.0965904764063157 0.421988255273135 0.0732089026211386 mirMAP -0.316063504281599 4.07580543518307e-05 NA NA NA hsa-miR-590-5p EGFR 0.763025362395968 3.65305892505623e-09 0.421988255273135 0.0732089026211386 miRanda;mirMAP -0.335383582937528 1.76757509066129e-05 NA NA NA hsa-miR-7-1-3p EGFR 1.13646121619622 1.49823237535933e-14 0.421988255273135 0.0732089026211386 mirMAP -0.275683965863029 4.44815829786658e-05 NA NA NA hsa-miR-9-5p EGFR 1.65694862043766 2.08325802567323e-05 0.421988255273135 0.0732089026211386 mirMAP -0.148975590966979 7.78083247312223e-09 23365639 We elected to validate our model in vitro by testing the effects of EGFR inhibition on downstream MYC miR-9 and let-7a expression; Our mathematical model explains the signaling link among EGFR MYC and miR-9 but not let-7 lung cancer hsa-miR-103a-3p EIF4B 0.556219385347418 1.55815736455067e-09 -0.62641897565296 1.23387091054055e-17 MirTarget;miRNATAP -0.117931433458342 0.000882954422210039 NA NA NA hsa-miR-15a-5p EIF4B 0.783550182002274 2.60699595655907e-11 -0.62641897565296 1.23387091054055e-17 miRNATAP -0.122377717206467 8.05532422543555e-06 NA NA NA hsa-miR-330-5p EIF4B 0.944693925383906 5.04972895657346e-13 -0.62641897565296 1.23387091054055e-17 miRNATAP -0.114130410687731 3.14202972751022e-06 NA NA NA hsa-miR-342-3p EIF4B 0.99756868977753 9.28499866272332e-10 -0.62641897565296 1.23387091054055e-17 miRanda -0.115015800194979 4.52869018419104e-09 NA NA NA hsa-miR-423-3p EIF4B 1.20230884409188 2.57129723627633e-23 -0.62641897565296 1.23387091054055e-17 miRNAWalker2_validate -0.123647038118901 1.86691163614015e-06 NA NA NA hsa-miR-25-3p EIF4E 0.76549796417801 3.32282098247097e-11 -0.262933625196079 0.00112545782482932 mirMAP -0.13676892354679 4.72116978925783e-06 NA NA NA hsa-miR-28-3p EIF4E 0.459875450032895 3.47095927872566e-07 -0.262933625196079 0.00112545782482932 mirMAP -0.15736763735348 5.16597820364993e-05 NA NA NA hsa-miR-30e-3p EIF4E -0.890635378639789 1.65740480611339e-16 -0.262933625196079 0.00112545782482932 mirMAP -0.131874726474787 3.12004490511946e-05 NA NA NA hsa-miR-340-5p EIF4E -0.608415693437977 4.44345153563513e-05 -0.262933625196079 0.00112545782482932 mirMAP -0.126944928816917 4.86525017462016e-08 NA NA NA hsa-miR-107 EIF4E2 -0.0447040564279497 0.671618791096755 -0.0413779426413807 0.591787741861913 miRanda -0.153727110860332 1.32120346723983e-06 NA NA NA hsa-miR-98-5p EIF4E2 0.0176698653376732 0.858271091070735 -0.0413779426413807 0.591787741861913 miRNAWalker2_validate -0.100046147489821 0.00341364300236721 NA NA NA hsa-miR-125b-5p EIF4EBP1 -0.993460109818276 5.07736727659894e-12 0.639128163333169 3.30033718127171e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.246150133132689 6.70763452586795e-08 17891175;26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ; prostate cancer;ovarian cancer hsa-miR-328-3p EIF4EBP1 0.153404163477345 0.292356842798574 0.639128163333169 3.30033718127171e-05 MirTarget -0.122043464998929 0.0087183508792019 NA NA NA hsa-miR-125a-5p EPHA2 0.215366061934933 0.119550904549401 -0.89230286460788 3.16570714720682e-07 miRanda -0.210671640733579 0.000151019599935608 NA NA NA hsa-miR-708-3p EPHA2 1.32647174389322 4.87465491977979e-16 -0.89230286460788 3.16570714720682e-07 MirTarget -0.145771609712637 0.00141205535253872 NA NA NA hsa-miR-326 EPO -0.425943992128769 0.0415010315530797 0.948511135768718 0.00514835311333976 miRanda -0.378848774524137 7.47414119649195e-08 NA NA NA hsa-miR-16-2-3p F2R 1.1567130855258 1.01867256952189e-14 1.12622975950636 1.11595926947831e-10 mirMAP -0.371206436651533 5.81690891491851e-14 NA NA NA hsa-miR-205-3p F2R 1.2960640797621 5.80786479909147e-11 1.12622975950636 1.11595926947831e-10 mirMAP -0.20763409206248 4.70329886636776e-08 NA NA NA hsa-miR-20a-3p F2R 1.34885093664027 2.07697464119202e-12 1.12622975950636 1.11595926947831e-10 MirTarget -0.180058149012431 4.50621665362598e-06 NA NA NA hsa-miR-23b-3p F2R -0.497563803223134 3.31483353357535e-05 1.12622975950636 1.11595926947831e-10 MirTarget -0.23183272414052 0.000318284968808056 NA NA NA hsa-miR-29a-5p F2R 0.323252792625584 0.0370417231222825 1.12622975950636 1.11595926947831e-10 MirTarget -0.155011671617631 0.00193722177546245 NA NA NA hsa-miR-361-5p F2R 0.0803683277369505 0.314043140368058 1.12622975950636 1.11595926947831e-10 miRanda -0.303827125319043 0.00209462003565266 NA NA NA hsa-miR-429 F2R 0.559451508722375 0.00563641638673083 1.12622975950636 1.11595926947831e-10 miRanda -0.305314651934967 2.18299471915816e-16 NA NA NA hsa-miR-582-5p F2R -0.0366995972742474 0.821827119138923 1.12622975950636 1.11595926947831e-10 MirTarget -0.314243991547348 1.97513330626638e-11 NA NA NA hsa-miR-589-3p F2R 1.59559692667315 6.2886410639161e-15 1.12622975950636 1.11595926947831e-10 MirTarget -0.116476603428049 0.00239727505856568 NA NA NA hsa-miR-590-3p F2R 0.221436901462551 0.0965904764063157 1.12622975950636 1.11595926947831e-10 miRanda;mirMAP;miRNATAP -0.159943803836499 0.00615274044164399 NA NA NA hsa-miR-590-5p F2R 0.763025362395968 3.65305892505623e-09 1.12622975950636 1.11595926947831e-10 miRanda -0.334822127892064 1.0798543357215e-08 NA NA NA hsa-miR-664a-3p F2R -0.256108763664991 0.0513188660751664 1.12622975950636 1.11595926947831e-10 mirMAP -0.226023273214804 0.000127160013439995 NA NA NA hsa-let-7e-5p FASLG 0.0857356192778891 0.512869729833211 0.394703525705912 0.21882393973136 miRNATAP -0.353388568642215 0.000974735688504158 NA NA NA hsa-miR-199a-5p FASLG -0.364835768178638 0.0435119211101981 0.394703525705912 0.21882393973136 miRanda -0.273318512204072 0.000400614015733864 NA NA NA hsa-miR-452-3p FASLG 1.09618110917892 2.21867884261816e-07 0.394703525705912 0.21882393973136 mirMAP -0.298192608882689 4.3334365675638e-06 NA NA NA hsa-miR-18a-5p FGF1 1.65455873230328 3.76457892277775e-20 -0.258011343667108 0.26760431731263 MirTarget -0.277496437672487 2.43959718026235e-07 NA NA NA hsa-miR-193a-3p FGF1 0.22120710726779 0.111827069464729 -0.258011343667108 0.26760431731263 PITA -0.202240172681954 0.00567870004542482 NA NA NA hsa-miR-205-5p FGF1 1.50759485376634 2.0003886738248e-16 -0.258011343667108 0.26760431731263 mirMAP -0.198163178508369 0.000211883664826537 NA NA NA hsa-miR-2355-5p FGF1 1.47205546931107 8.65192179636668e-19 -0.258011343667108 0.26760431731263 MirTarget -0.185602955162296 0.00160680328845676 NA NA NA hsa-miR-484 FGF1 0.918280909791707 1.39168306854263e-14 -0.258011343667108 0.26760431731263 MirTarget;PITA;miRNATAP -0.389291918702885 2.4520525029842e-06 NA NA NA hsa-miR-532-3p FGF1 0.80240056676907 1.08989551712617e-09 -0.258011343667108 0.26760431731263 miRNATAP -0.216024621372653 0.004507077796501 NA NA NA hsa-miR-576-5p FGF1 0.940432050128373 6.90227595663302e-12 -0.258011343667108 0.26760431731263 PITA;mirMAP -0.292914912309583 5.16069042343911e-05 NA NA NA hsa-miR-590-5p FGF1 0.763025362395968 3.65305892505623e-09 -0.258011343667108 0.26760431731263 MirTarget;miRanda;miRNATAP -0.317241137495249 3.95390401682399e-05 NA NA NA hsa-miR-629-5p FGF1 0.461215538037447 8.95262667860215e-06 -0.258011343667108 0.26760431731263 MirTarget -0.658892526979509 6.2109593316048e-12 NA NA NA hsa-miR-944 FGF1 1.47323925060177 2.61626403984929e-13 -0.258011343667108 0.26760431731263 mirMAP -0.319683604411362 3.57117911228316e-11 NA NA NA hsa-let-7f-5p FGF11 -0.441845198213823 0.00242957484218694 0.817619191220799 0.000125130498795574 mirMAP;miRNATAP -0.252953039973085 7.44143657639289e-05 NA NA NA hsa-let-7g-5p FGF11 -0.250780249469264 0.00939610188330072 0.817619191220799 0.000125130498795574 mirMAP;miRNATAP -0.370971716833525 0.000137291311349804 NA NA NA hsa-miR-125b-5p FGF11 -0.993460109818276 5.07736727659894e-12 0.817619191220799 0.000125130498795574 mirMAP -0.24169989978906 0.000142160166852154 NA NA NA hsa-miR-181c-5p FGF11 -0.168991199007857 0.196949106150297 0.817619191220799 0.000125130498795574 mirMAP -0.20614633962775 0.00401693406111408 NA NA NA hsa-miR-195-5p FGF11 -1.8367376818177 6.9944883988895e-31 0.817619191220799 0.000125130498795574 mirMAP -0.198302055931528 0.000331638911045397 NA NA NA hsa-miR-217 FGF11 -1.35391381055929 2.42394951427902e-09 0.817619191220799 0.000125130498795574 PITA;miRanda -0.10449304001688 0.0099270377926623 NA NA NA hsa-miR-221-5p FGF11 -0.53190793287441 0.0379158336541952 0.817619191220799 0.000125130498795574 miRNATAP -0.119704813324824 0.000984850545712735 NA NA NA hsa-miR-28-5p FGF11 -0.026996999089909 0.733047113251652 0.817619191220799 0.000125130498795574 miRanda -0.404088723713172 0.000764907597908066 NA NA NA hsa-miR-326 FGF11 -0.425943992128769 0.0415010315530797 0.817619191220799 0.000125130498795574 MirTarget;PITA;miRanda;miRNATAP -0.205709585070413 3.91411336469149e-06 NA NA NA hsa-miR-628-5p FGF11 -0.554239048796013 4.92386883216087e-05 0.817619191220799 0.000125130498795574 miRNATAP -0.361198975570433 8.93992785542876e-08 NA NA NA hsa-miR-142-5p FGF12 0.288897753038094 0.0900009317815725 -0.582614717688515 0.0551727720869136 miRNATAP -0.329957050688491 2.05218174125255e-05 NA NA NA hsa-miR-205-3p FGF12 1.2960640797621 5.80786479909147e-11 -0.582614717688515 0.0551727720869136 MirTarget -0.272629135698617 3.0622926253504e-05 NA NA NA hsa-miR-2355-3p FGF12 1.58434563546762 4.06578912176206e-18 -0.582614717688515 0.0551727720869136 MirTarget;miRNATAP -0.38448285919751 3.04446467725463e-08 NA NA NA hsa-miR-29a-5p FGF12 0.323252792625584 0.0370417231222825 -0.582614717688515 0.0551727720869136 MirTarget -0.38111533263344 7.52153613120094e-06 NA NA NA hsa-miR-342-3p FGF12 0.99756868977753 9.28499866272332e-10 -0.582614717688515 0.0551727720869136 miRanda -0.340856513705552 1.90111712777334e-05 NA NA NA hsa-miR-450b-5p FGF12 1.25529820885833 1.18847120528666e-15 -0.582614717688515 0.0551727720869136 miRNATAP -0.237099192523695 0.00393637076050291 NA NA NA hsa-miR-455-5p FGF12 1.408595672323 5.52039116456697e-22 -0.582614717688515 0.0551727720869136 miRanda -0.551210175951459 1.29665519180675e-10 NA NA NA hsa-miR-511-5p FGF12 0.214339847118675 0.232372953100021 -0.582614717688515 0.0551727720869136 MirTarget -0.232230880342727 0.00166625415209001 NA NA NA hsa-miR-542-3p FGF12 0.643308814904977 8.81635403230104e-07 -0.582614717688515 0.0551727720869136 miRanda -0.329632103105734 0.00104162237655472 NA NA NA hsa-miR-576-5p FGF12 0.940432050128373 6.90227595663302e-12 -0.582614717688515 0.0551727720869136 mirMAP -0.408242189119232 1.55698433321357e-05 NA NA NA hsa-let-7b-3p FGF13 0.120166961637302 0.299224004314356 -1.46301246813209 1.10281013324847e-05 MirTarget;miRNATAP -0.395582167462648 0.00186130582510831 NA NA NA hsa-let-7f-1-3p FGF13 0.700374242293247 8.65000484720084e-08 -1.46301246813209 1.10281013324847e-05 MirTarget -0.413328586300836 0.000184731392195485 NA NA NA hsa-miR-141-3p FGF13 0.730011517758706 0.000120338355004032 -1.46301246813209 1.10281013324847e-05 TargetScan -0.217008682104236 0.00461729582654458 NA NA NA hsa-miR-142-5p FGF13 0.288897753038094 0.0900009317815725 -1.46301246813209 1.10281013324847e-05 PITA -0.257065161129666 0.00275687664306998 NA NA NA hsa-miR-31-3p FGF13 2.10124531535908 1.70135756565194e-08 -1.46301246813209 1.10281013324847e-05 miRNATAP -0.318757205751666 1.9138000549862e-17 NA NA NA hsa-miR-3682-3p FGF13 0.707626231028898 1.50609185515014e-05 -1.46301246813209 1.10281013324847e-05 MirTarget -0.251232120368971 0.00488545679786259 NA NA NA hsa-miR-455-5p FGF13 1.408595672323 5.52039116456697e-22 -1.46301246813209 1.10281013324847e-05 PITA;miRanda -0.744922261520023 1.82247837214577e-15 NA NA NA hsa-miR-7-1-3p FGF13 1.13646121619622 1.49823237535933e-14 -1.46301246813209 1.10281013324847e-05 MirTarget;mirMAP -0.347115115224032 0.000314178039831248 NA NA NA hsa-miR-193a-5p FGF14 0.351460703308937 0.00347717541215117 -1.62704249037492 1.3148897101317e-07 TargetScan -0.406581901327017 0.0003265222795513 NA NA NA hsa-miR-590-3p FGF14 0.221436901462551 0.0965904764063157 -1.62704249037492 1.3148897101317e-07 miRanda -0.42830851823148 2.68300448941013e-05 NA NA NA hsa-miR-96-5p FGF14 1.42326703011157 4.39736150032373e-14 -1.62704249037492 1.3148897101317e-07 TargetScan -0.337834021759798 1.31045376791808e-06 NA NA NA hsa-miR-103a-3p FGF18 0.556219385347418 1.55815736455067e-09 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.496370794423683 0.000332281911081466 NA NA NA hsa-miR-15a-5p FGF18 0.783550182002274 2.60699595655907e-11 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.702693009108968 3.09754498733063e-11 NA NA NA hsa-miR-15b-5p FGF18 0.85315666454713 3.79816274836297e-12 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.546279443338623 7.76425760723514e-08 NA NA NA hsa-miR-16-5p FGF18 0.521122945828175 1.40561786410572e-06 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.634380188554347 6.35545983795006e-08 NA NA NA hsa-miR-200b-3p FGF18 0.0717138787925347 0.682858087587209 -1.88786711762185 6.1965148779705e-11 TargetScan -0.338800867319404 3.20904303944546e-06 NA NA NA hsa-miR-200c-3p FGF18 0.630251054099546 0.000131975031451555 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.491042406920311 1.19246477608829e-10 NA NA NA hsa-miR-21-5p FGF18 1.62465922021121 3.44191300985109e-58 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.522565820217367 3.80501286581297e-06 NA NA NA hsa-miR-330-5p FGF18 0.944693925383906 5.04972895657346e-13 -1.88786711762185 6.1965148779705e-11 PITA;miRanda;miRNATAP -0.364911036381969 0.000141889829673744 NA NA NA hsa-miR-424-5p FGF18 1.48125289532143 9.10372985713165e-19 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.411226086316741 1.91859919749703e-08 NA NA NA hsa-miR-429 FGF18 0.559451508722375 0.00563641638673083 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.383425444613611 8.10623231086834e-10 NA NA NA hsa-miR-505-3p FGF18 0.912823669571645 4.0549774967148e-13 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.45816431477501 4.02225324767235e-06 NA NA NA hsa-miR-590-5p FGF18 0.763025362395968 3.65305892505623e-09 -1.88786711762185 6.1965148779705e-11 miRanda;miRNATAP -0.628733840517059 7.22877221668898e-11 NA NA NA hsa-miR-193a-3p FGF19 0.22120710726779 0.111827069464729 1.92934227956647 8.15438676803874e-05 miRanda -0.541295534008293 0.000464328018223873 NA NA NA hsa-let-7a-3p FGF2 0.0966652362351867 0.423761916840503 -0.873895268607156 0.000749629544409884 mirMAP -0.346697326213815 0.000235155196874588 NA NA NA hsa-miR-15a-5p FGF2 0.783550182002274 2.60699595655907e-11 -0.873895268607156 0.000749629544409884 MirTarget;miRNATAP -0.337568241456238 0.000380629759701841 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 0.955017760172879 5.95379292601146e-11 -0.873895268607156 0.000749629544409884 mirMAP -0.216053774665656 0.00482669676692554 NA NA NA hsa-miR-19b-1-5p FGF2 0.757034032029085 2.99828133413343e-07 -0.873895268607156 0.000749629544409884 mirMAP -0.299411866060348 7.91846938731196e-05 NA NA NA hsa-miR-20a-3p FGF2 1.34885093664027 2.07697464119202e-12 -0.873895268607156 0.000749629544409884 mirMAP -0.254686140332496 9.5611184793422e-06 NA NA NA hsa-miR-21-3p FGF2 1.25126438776674 2.4124216716282e-17 -0.873895268607156 0.000749629544409884 mirMAP -0.32497551048351 1.17275178306699e-05 NA NA NA hsa-miR-21-5p FGF2 1.62465922021121 3.44191300985109e-58 -0.873895268607156 0.000749629544409884 mirMAP -0.383531284677615 0.000132348473852467 NA NA NA hsa-miR-221-3p FGF2 0.410625614724387 0.000741090075261272 -0.873895268607156 0.000749629544409884 mirMAP -0.449825295563516 1.20603425503909e-06 NA NA NA hsa-miR-222-3p FGF2 1.08197052578759 2.32604040301699e-14 -0.873895268607156 0.000749629544409884 mirMAP -0.480077702405072 4.64663204454521e-10 NA NA NA hsa-miR-424-5p FGF2 1.48125289532143 9.10372985713165e-19 -0.873895268607156 0.000749629544409884 MirTarget;miRNATAP -0.246395124820535 0.000160269078978561 NA NA NA hsa-miR-429 FGF2 0.559451508722375 0.00563641638673083 -0.873895268607156 0.000749629544409884 mirMAP -0.179751399599829 0.00131313676812878 NA NA NA hsa-miR-450b-5p FGF2 1.25529820885833 1.18847120528666e-15 -0.873895268607156 0.000749629544409884 mirMAP -0.227108898055622 0.001244749731088 NA NA NA hsa-miR-452-5p FGF2 0.373288744398455 0.0348485937209964 -0.873895268607156 0.000749629544409884 mirMAP -0.346192872192568 4.93639730457593e-08 NA NA NA hsa-miR-503-5p FGF2 2.85210590411715 1.27298190263569e-35 -0.873895268607156 0.000749629544409884 miRNAWalker2_validate -0.222158187558667 3.87633414352609e-06 NA NA NA hsa-miR-589-3p FGF2 1.59559692667315 6.2886410639161e-15 -0.873895268607156 0.000749629544409884 mirMAP -0.162744204065903 0.00378641086950463 NA NA NA hsa-miR-590-5p FGF2 0.763025362395968 3.65305892505623e-09 -0.873895268607156 0.000749629544409884 miRanda;mirMAP -0.362188154730295 2.75175904757516e-05 NA NA NA hsa-miR-92a-3p FGF2 0.994679542307232 1.32587679156217e-16 -0.873895268607156 0.000749629544409884 miRNAWalker2_validate -0.350572454919679 0.000131198641822221 NA NA NA hsa-miR-944 FGF2 1.47323925060177 2.61626403984929e-13 -0.873895268607156 0.000749629544409884 MirTarget -0.297247292575655 4.68482644368958e-08 NA NA NA hsa-miR-155-5p FGF5 0.533437622040649 0.00248671179205372 2.03532963351149 1.96791908743617e-07 mirMAP -0.31284053064953 0.00133764239981059 NA NA NA hsa-miR-15b-5p FGF5 0.85315666454713 3.79816274836297e-12 2.03532963351149 1.96791908743617e-07 miRNAWalker2_validate -0.539510689376273 8.89932041304568e-05 NA NA NA hsa-miR-16-1-3p FGF5 0.955017760172879 5.95379292601146e-11 2.03532963351149 1.96791908743617e-07 mirMAP -0.435673839937129 0.000178123016562154 NA NA NA hsa-miR-30b-5p FGF5 -0.400238605368173 0.00346540992719245 2.03532963351149 1.96791908743617e-07 mirMAP -0.584264957941181 3.11677593098393e-06 NA NA NA hsa-miR-30c-5p FGF5 0.021222006155897 0.886366656528128 2.03532963351149 1.96791908743617e-07 mirMAP -0.414523178107725 0.000368274960248606 NA NA NA hsa-miR-30d-5p FGF5 -0.38399848121878 0.000171129616944749 2.03532963351149 1.96791908743617e-07 mirMAP -0.830892592830511 7.77553120763636e-07 NA NA NA hsa-miR-30e-5p FGF5 -1.02114836019762 6.81961221797866e-17 2.03532963351149 1.96791908743617e-07 mirMAP -1.010076240996 5.35877622269213e-14 NA NA NA hsa-miR-33a-3p FGF5 0.20371038027126 0.212335697664505 2.03532963351149 1.96791908743617e-07 mirMAP -0.564415390474596 1.13151442887737e-07 NA NA NA hsa-miR-3607-3p FGF5 1.01377165357363 9.13355519701165e-05 2.03532963351149 1.96791908743617e-07 miRNATAP -0.243752423074476 0.000221294949256888 NA NA NA hsa-miR-374a-5p FGF5 -0.621903385111545 6.61791773205282e-12 2.03532963351149 1.96791908743617e-07 mirMAP -0.578953744206145 0.00214972210165144 NA NA NA hsa-miR-374b-5p FGF5 -0.288413933608091 0.0041474558664058 2.03532963351149 1.96791908743617e-07 mirMAP -0.460448246804867 0.00769448722291093 NA NA NA hsa-miR-582-5p FGF5 -0.0366995972742474 0.821827119138923 2.03532963351149 1.96791908743617e-07 mirMAP -0.438895718657925 3.30028681894977e-05 NA NA NA hsa-miR-7-1-3p FGF5 1.13646121619622 1.49823237535933e-14 2.03532963351149 1.96791908743617e-07 mirMAP -0.491319043524203 1.46162304642574e-05 NA NA NA hsa-miR-9-5p FGF5 1.65694862043766 2.08325802567323e-05 2.03532963351149 1.96791908743617e-07 mirMAP;miRNATAP -0.319095858366486 1.04359689832769e-13 NA NA NA hsa-let-7a-3p FGF7 0.0966652362351867 0.423761916840503 -2.01548136096491 3.47916106415079e-16 MirTarget;miRNATAP -0.407412421508281 9.39576644959233e-06 NA NA NA hsa-miR-15a-5p FGF7 0.783550182002274 2.60699595655907e-11 -2.01548136096491 3.47916106415079e-16 miRTarBase;miRNATAP -0.758176143394721 5.17214837920814e-17 NA NA NA hsa-miR-15b-5p FGF7 0.85315666454713 3.79816274836297e-12 -2.01548136096491 3.47916106415079e-16 miRNATAP -0.568341530637 8.06625251176299e-11 NA NA NA hsa-miR-16-1-3p FGF7 0.955017760172879 5.95379292601146e-11 -2.01548136096491 3.47916106415079e-16 mirMAP -0.582550949106155 1.52037236233235e-15 NA NA NA hsa-miR-16-2-3p FGF7 1.1567130855258 1.01867256952189e-14 -2.01548136096491 3.47916106415079e-16 mirMAP -0.662388065162359 1.98377986171799e-21 NA NA NA hsa-miR-16-5p FGF7 0.521122945828175 1.40561786410572e-06 -2.01548136096491 3.47916106415079e-16 miRNATAP -0.528266917563882 2.01078150816863e-07 NA NA NA hsa-miR-18a-3p FGF7 1.82583720936229 7.51297960972179e-19 -2.01548136096491 3.47916106415079e-16 MirTarget -0.46844558781355 1.08349793094373e-19 NA NA NA hsa-miR-205-3p FGF7 1.2960640797621 5.80786479909147e-11 -2.01548136096491 3.47916106415079e-16 mirMAP -0.547481712642976 1.77873769265097e-25 NA NA NA hsa-miR-20a-5p FGF7 1.1531986665452 1.02385132917958e-11 -2.01548136096491 3.47916106415079e-16 miRNAWalker2_validate -0.613419630660297 2.02970970138624e-23 NA NA NA hsa-miR-27a-3p FGF7 0.348456440505425 0.00126682892514312 -2.01548136096491 3.47916106415079e-16 MirTarget -0.485890878724566 2.08331319035218e-06 NA NA NA hsa-miR-31-5p FGF7 2.79079137807505 1.72181058015659e-13 -2.01548136096491 3.47916106415079e-16 MirTarget -0.251497031870126 2.0735964251059e-19 NA NA NA hsa-miR-320a FGF7 0.801356001806321 4.91397101474502e-09 -2.01548136096491 3.47916106415079e-16 miRanda -0.344732081653175 1.52541649148947e-05 NA NA NA hsa-miR-320b FGF7 1.23473838180754 3.04337566045537e-14 -2.01548136096491 3.47916106415079e-16 miRanda -0.306922120859187 3.56854180676285e-06 NA NA NA hsa-miR-33a-3p FGF7 0.20371038027126 0.212335697664505 -2.01548136096491 3.47916106415079e-16 mirMAP -0.267156731589519 0.000105178848642306 NA NA NA hsa-miR-3607-3p FGF7 1.01377165357363 9.13355519701165e-05 -2.01548136096491 3.47916106415079e-16 mirMAP -0.231628164127034 3.82613094762849e-08 NA NA NA hsa-miR-424-5p FGF7 1.48125289532143 9.10372985713165e-19 -2.01548136096491 3.47916106415079e-16 miRNATAP -0.320726779959208 4.43814875864373e-07 NA NA NA hsa-miR-429 FGF7 0.559451508722375 0.00563641638673083 -2.01548136096491 3.47916106415079e-16 miRNATAP -0.456460483342231 8.35745432718304e-18 NA NA NA hsa-miR-452-5p FGF7 0.373288744398455 0.0348485937209964 -2.01548136096491 3.47916106415079e-16 mirMAP -0.295494838128618 2.11954883967322e-06 NA NA NA hsa-miR-455-3p FGF7 2.68574446868387 4.28975903022818e-42 -2.01548136096491 3.47916106415079e-16 PITA;miRNATAP -0.510499869886505 3.92708976432283e-25 NA NA NA hsa-miR-484 FGF7 0.918280909791707 1.39168306854263e-14 -2.01548136096491 3.47916106415079e-16 PITA -0.553887894998084 6.92443925890007e-10 NA NA NA hsa-miR-501-5p FGF7 1.02806906860218 1.63456814370548e-09 -2.01548136096491 3.47916106415079e-16 PITA;mirMAP -0.268272897559334 3.42494201805503e-05 NA NA NA hsa-miR-590-3p FGF7 0.221436901462551 0.0965904764063157 -2.01548136096491 3.47916106415079e-16 PITA;miRanda;mirMAP;miRNATAP -0.27812954133398 0.000866348391234384 NA NA NA hsa-miR-590-5p FGF7 0.763025362395968 3.65305892505623e-09 -2.01548136096491 3.47916106415079e-16 PITA;miRanda -0.701558117453836 1.5867556887698e-17 NA NA NA hsa-miR-7-1-3p FGF7 1.13646121619622 1.49823237535933e-14 -2.01548136096491 3.47916106415079e-16 mirMAP -0.458342824311289 2.15620787170561e-10 NA NA NA hsa-miR-708-3p FGF7 1.32647174389322 4.87465491977979e-16 -2.01548136096491 3.47916106415079e-16 mirMAP -0.437698752984361 1.47737195240182e-11 NA NA NA hsa-miR-944 FGF7 1.47323925060177 2.61626403984929e-13 -2.01548136096491 3.47916106415079e-16 mirMAP -0.37225697445087 1.67116584248206e-12 NA NA NA hsa-miR-142-3p FGF9 1.12754191614028 1.68798138028946e-08 -1.38200824505352 9.05347102190895e-06 miRanda -0.259765933502149 0.000113295496265394 NA NA NA hsa-miR-15a-5p FGF9 0.783550182002274 2.60699595655907e-11 -1.38200824505352 9.05347102190895e-06 miRNATAP -0.357865605085935 0.0018124991757053 NA NA NA hsa-miR-16-2-3p FGF9 1.1567130855258 1.01867256952189e-14 -1.38200824505352 9.05347102190895e-06 mirMAP -0.375706331819685 2.36450540389056e-05 NA NA NA hsa-miR-205-5p FGF9 1.50759485376634 2.0003886738248e-16 -1.38200824505352 9.05347102190895e-06 miRNATAP -0.416585862637498 5.72993182011151e-09 NA NA NA hsa-miR-330-5p FGF9 0.944693925383906 5.04972895657346e-13 -1.38200824505352 9.05347102190895e-06 miRanda;miRNATAP -0.282467140589527 0.00592832027325082 NA NA NA hsa-miR-455-5p FGF9 1.408595672323 5.52039116456697e-22 -1.38200824505352 9.05347102190895e-06 miRanda -0.519010790529783 5.18865705861902e-09 NA NA NA hsa-miR-590-5p FGF9 0.763025362395968 3.65305892505623e-09 -1.38200824505352 9.05347102190895e-06 miRanda -0.334500927773077 0.00137367059889734 NA NA NA hsa-miR-744-3p FGF9 1.18973028739247 4.23716909078104e-10 -1.38200824505352 9.05347102190895e-06 miRNATAP -0.209668103890808 0.00297574939478547 NA NA NA hsa-miR-944 FGF9 1.47323925060177 2.61626403984929e-13 -1.38200824505352 9.05347102190895e-06 mirMAP -0.244896095804246 0.000212430618962972 NA NA NA hsa-miR-96-5p FGF9 1.42326703011157 4.39736150032373e-14 -1.38200824505352 9.05347102190895e-06 TargetScan;miRNATAP -0.191745648143166 0.00674766951778037 NA NA NA hsa-miR-106a-5p FGFR1 0.67978010057847 0.00221925869726092 -0.285304743310302 0.171119486865196 mirMAP -0.129847841479432 0.00140745214014729 NA NA NA hsa-miR-135b-5p FGFR1 1.5570143078477 4.60753610971455e-13 -0.285304743310302 0.171119486865196 mirMAP -0.281548954961466 3.25890310081625e-12 NA NA NA hsa-miR-15a-5p FGFR1 0.783550182002274 2.60699595655907e-11 -0.285304743310302 0.171119486865196 miRNATAP -0.403658939025052 8.79750014830109e-08 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGFR1 0.85315666454713 3.79816274836297e-12 -0.285304743310302 0.171119486865196 miRNATAP -0.214437670759984 0.00317282993888603 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 0.521122945828175 1.40561786410572e-06 -0.285304743310302 0.171119486865196 miRTarBase;miRNATAP -0.38922203488893 3.0006114587061e-06 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 1.41924888736771 2.75805544953758e-18 -0.285304743310302 0.171119486865196 mirMAP -0.338598823690165 1.88464331446601e-10 NA NA NA hsa-miR-200a-5p FGFR1 0.701063526850019 0.000188402923774663 -0.285304743310302 0.171119486865196 mirMAP -0.347565186416522 1.54236670618255e-13 NA NA NA hsa-miR-200b-5p FGFR1 0.02621402664548 0.883725338810228 -0.285304743310302 0.171119486865196 mirMAP -0.319684954127201 1.58203496685162e-10 NA NA NA hsa-miR-20a-5p FGFR1 1.1531986665452 1.02385132917958e-11 -0.285304743310302 0.171119486865196 mirMAP -0.317108473561725 9.27549337118698e-10 NA NA NA hsa-miR-2355-5p FGFR1 1.47205546931107 8.65192179636668e-19 -0.285304743310302 0.171119486865196 mirMAP -0.299822634669823 8.84769794668989e-09 NA NA NA hsa-miR-301a-3p FGFR1 2.14132004241926 4.46255413526808e-25 -0.285304743310302 0.171119486865196 mirMAP -0.169994723601377 4.35783491979539e-05 NA NA NA hsa-miR-455-5p FGFR1 1.408595672323 5.52039116456697e-22 -0.285304743310302 0.171119486865196 miRanda -0.313824859592463 1.11413040800983e-07 NA NA NA hsa-miR-590-3p FGFR1 0.221436901462551 0.0965904764063157 -0.285304743310302 0.171119486865196 miRanda;mirMAP -0.267304203534255 8.80534628406325e-05 NA NA NA hsa-miR-93-5p FGFR1 1.61042951896619 5.1280369606967e-24 -0.285304743310302 0.171119486865196 mirMAP -0.169176457028053 0.00188566230333975 NA NA NA hsa-let-7a-3p FGFR2 0.0966652362351867 0.423761916840503 -0.689192404124544 0.00027530593494015 miRNATAP -0.193564939031614 0.00509899325895667 NA NA NA hsa-miR-146b-5p FGFR2 0.917975986853978 3.33749259316025e-09 -0.689192404124544 0.00027530593494015 miRanda -0.315268061524928 1.36606510703905e-09 NA NA NA hsa-miR-186-5p FGFR2 0.353452958261612 0.000145058448579496 -0.689192404124544 0.00027530593494015 miRNAWalker2_validate -0.392401143571198 1.09634780638378e-05 NA NA NA hsa-miR-193a-3p FGFR2 0.22120710726779 0.111827069464729 -0.689192404124544 0.00027530593494015 miRanda -0.357501509299468 1.39512863622931e-09 NA NA NA hsa-miR-330-5p FGFR2 0.944693925383906 5.04972895657346e-13 -0.689192404124544 0.00027530593494015 miRanda -0.214084238420235 0.000567628023207746 NA NA NA hsa-miR-338-3p FGFR2 -0.948755228846395 8.99167125682392e-08 -0.689192404124544 0.00027530593494015 miRanda;miRNATAP -0.175050696307873 0.000145068088792403 NA NA NA hsa-miR-542-3p FGFR2 0.643308814904977 8.81635403230104e-07 -0.689192404124544 0.00027530593494015 miRanda -0.356945364566282 9.9855269919112e-09 NA NA NA hsa-miR-100-5p FGFR3 -1.85857794619369 1.248973638996e-25 0.0735667865321687 0.750912348559634 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.177527076547578 0.00100959147184781 25344675;26604796;26018508;23778527 MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3;Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress ;;;poor survival pancreatic cancer;glioblastoma;sarcoma;bladder cancer hsa-miR-337-3p FGFR3 -1.70091836051933 1.39844536073221e-13 0.0735667865321687 0.750912348559634 MirTarget -0.158736976879148 0.000197575798793529 NA NA NA hsa-miR-99b-5p FGFR3 0.44137573438014 9.0939587647735e-05 0.0735667865321687 0.750912348559634 MirTarget;miRNATAP -0.313791397643478 0.000443612699243026 22969861 miR-99b was downregulated and FGFR3 was upregulated in lung cancer patients; We demonstrated that the overexpression of miR-99b induced a reduction in FGFR3 expression and confirmed the target specificity between miR-99b and the FGFR3 3'-untranslated region by luciferase reporter assay; Taken together these results suggest that miR-99b may be a tumor suppressor through the downregulation of FGFR3 miR-99b may be a potent tumor suppressor and may be a potential therapeutic tool for patients with lung cancer lung squamous cell cancer hsa-miR-10b-5p FLT1 -0.582989331935508 4.56688330655626e-06 0.739056195142607 2.68348183147666e-07 miRNATAP -0.192188128519245 9.91761533013577e-05 NA NA NA hsa-miR-139-5p FLT1 -1.46099200329485 7.85040381494472e-22 0.739056195142607 2.68348183147666e-07 miRanda -0.11787062655249 0.00316478819500311 NA NA NA hsa-miR-155-5p FLT1 0.533437622040649 0.00248671179205372 0.739056195142607 2.68348183147666e-07 miRNAWalker2_validate;mirMAP -0.110593121592625 0.00199016890826031 NA NA NA hsa-miR-17-5p FLT1 1.41924888736771 2.75805544953758e-18 0.739056195142607 2.68348183147666e-07 MirTarget;TargetScan;miRNATAP -0.162121991393848 1.47356802980238e-05 NA NA NA hsa-miR-19a-3p FLT1 1.35800152353624 2.80940447111944e-12 0.739056195142607 2.68348183147666e-07 MirTarget -0.201798812780327 1.21924202721184e-10 NA NA NA hsa-miR-19b-3p FLT1 0.538732279378089 0.000622008277870679 0.739056195142607 2.68348183147666e-07 MirTarget -0.317725439140663 3.71017620829984e-16 NA NA NA hsa-miR-200b-3p FLT1 0.0717138787925347 0.682858087587209 0.739056195142607 2.68348183147666e-07 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.21472836717083 1.68717821914887e-09 21115742 Forced miR-200 expression suppressed Flt1 levels in metastasis-prone lung adenocarcinoma cells derived from K-ras/p53-mutant mice and negatively regulated the Flt1 3'-UTR in reporter assays; We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1 metastasis;tumorigenesis lung cancer hsa-miR-200c-3p FLT1 0.630251054099546 0.000131975031451555 0.739056195142607 2.68348183147666e-07 miRNAWalker2_validate;miRTarBase;MirTarget -0.155166327420166 4.55528929071695e-05 NA NA NA hsa-miR-20a-5p FLT1 1.1531986665452 1.02385132917958e-11 0.739056195142607 2.68348183147666e-07 MirTarget;miRNATAP -0.2101141978095 6.20723911885894e-09 NA NA NA hsa-miR-22-5p FLT1 0.706731861922839 3.44318705980007e-07 0.739056195142607 2.68348183147666e-07 MirTarget -0.128868934444222 0.00442712563484919 NA NA NA hsa-miR-29a-5p FLT1 0.323252792625584 0.0370417231222825 0.739056195142607 2.68348183147666e-07 MirTarget -0.196605828184586 1.25614350546622e-06 NA NA NA hsa-miR-338-3p FLT1 -0.948755228846395 8.99167125682392e-08 0.739056195142607 2.68348183147666e-07 miRanda -0.23083752446508 2.65782382187301e-11 NA NA NA hsa-miR-339-5p FLT1 1.07771430326938 2.45772601859307e-09 0.739056195142607 2.68348183147666e-07 miRanda -0.210575720734462 5.88314950670275e-10 NA NA NA hsa-miR-429 FLT1 0.559451508722375 0.00563641638673083 0.739056195142607 2.68348183147666e-07 MirTarget;miRanda;miRNATAP -0.197816271100719 1.22507430866117e-10 NA NA NA hsa-miR-576-5p FLT1 0.940432050128373 6.90227595663302e-12 0.739056195142607 2.68348183147666e-07 mirMAP -0.138330160162659 0.00226939258205763 NA NA NA hsa-miR-590-3p FLT1 0.221436901462551 0.0965904764063157 0.739056195142607 2.68348183147666e-07 miRanda -0.175486366281917 0.000222722325309575 NA NA NA hsa-miR-93-5p FLT1 1.61042951896619 5.1280369606967e-24 0.739056195142607 2.68348183147666e-07 MirTarget;miRNATAP -0.100635677473224 0.00805288617306077 NA NA NA hsa-miR-429 FLT4 0.559451508722375 0.00563641638673083 0.430026618879815 0.0189031619744705 miRanda;miRNATAP -0.322758344483548 3.44738607527909e-17 NA NA NA hsa-miR-139-5p FN1 -1.46099200329485 7.85040381494472e-22 2.78343880028279 3.22101829842294e-17 miRanda -0.397624297619191 2.04335587806596e-05 NA NA NA hsa-miR-16-1-3p FN1 0.955017760172879 5.95379292601146e-11 2.78343880028279 3.22101829842294e-17 mirMAP -0.344687687792994 0.000578388427387105 NA NA NA hsa-miR-200b-3p FN1 0.0717138787925347 0.682858087587209 2.78343880028279 3.22101829842294e-17 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.85508565290465 3.30241914054747e-26 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-200c-3p FN1 0.630251054099546 0.000131975031451555 2.78343880028279 3.22101829842294e-17 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.52616655899907 2.8116818593274e-09 NA NA NA hsa-miR-26b-5p FN1 -0.254478038884324 0.0285227763044636 2.78343880028279 3.22101829842294e-17 miRNAWalker2_validate -0.698406314760611 3.95140817452624e-08 NA NA NA hsa-miR-27b-3p FN1 -0.732682718863563 2.26896143573324e-09 2.78343880028279 3.22101829842294e-17 MirTarget -0.929284565080484 1.77191082805626e-15 NA NA NA hsa-miR-33a-3p FN1 0.20371038027126 0.212335697664505 2.78343880028279 3.22101829842294e-17 mirMAP -0.50582053448796 3.22008559767904e-08 NA NA NA hsa-miR-429 FN1 0.559451508722375 0.00563641638673083 2.78343880028279 3.22101829842294e-17 MirTarget;PITA;miRanda;miRNATAP -0.586018949436659 1.98632253495529e-16 NA NA NA hsa-miR-590-3p FN1 0.221436901462551 0.0965904764063157 2.78343880028279 3.22101829842294e-17 miRanda;mirMAP -0.413484695477004 0.000210904650356996 NA NA NA hsa-miR-96-5p FN1 1.42326703011157 4.39736150032373e-14 2.78343880028279 3.22101829842294e-17 MirTarget;TargetScan -0.278728253380574 0.000274554771793394 NA NA NA hsa-let-7a-3p FOXO3 0.0966652362351867 0.423761916840503 -0.326231432881512 0.00103053272543976 mirMAP;miRNATAP -0.200531082947721 2.00089307431163e-08 NA NA NA hsa-miR-130a-3p FOXO3 0.67051191119964 4.89747518735144e-06 -0.326231432881512 0.00103053272543976 mirMAP -0.168872324769289 5.96037012129511e-09 NA NA NA hsa-miR-155-5p FOXO3 0.533437622040649 0.00248671179205372 -0.326231432881512 0.00103053272543976 miRNAWalker2_validate;miRTarBase -0.117539461363734 1.41050306563265e-06 27596294;25480585;20371610;26398931;22027557;27107135 MiR-155 targets 3´UTR region of multiple components of the pro-oncogenic signaling cascades including FOXO3a tumor suppressor and RUNX2 transcription factor regulating metastatic potential in BC;The effect of miRNA155 on FOXO3a expression was examined by Western blotting; FOXO3a was found to be a possible target of miRNA155 as suggested by Targetscan website;MicroRNA 155 regulates cell survival growth and chemosensitivity by targeting FOXO3a in breast cancer; In this study we demonstrate the critical role of miR-155 in regulation of cell survival and chemosensitivity through down-regulation of FOXO3a in breast cancer; Further we identified FOXO3a as a direct target of miR-155; Sustained overexpression of miR-155 resulted in repression of FOXO3a protein without changing mRNA levels and knockdown of miR-155 increases FOXO3a; Finally inverse correlation between miR-155 and FOXO3a levels were observed in a panel of breast cancer cell lines and tumors; In conclusion our study reveals a molecular link between miR-155 and FOXO3a and presents evidence that miR-155 is a critical therapeutic target in breast cancer;In contrast downregulation of miR-155-5p increased sensitivity to bufalin and upregulated the expression of FOXO3A;Here we show that hypoxic conditions induce miR-155 expression in lung cancer cells and trigger a corresponding decrease in a validated target FOXO3A;Our results further revealed that forkhead box O3a FoxO3a was a miR-155 target in the heart; And miR-155 directly repressed FoxO3a whose expression was mitigated in miR-155 agomir and mimic treatment in vivo and in vitro ;;poor survival;;; breast cancer;lymphoma;breast cancer;breast cancer;lung cancer;breast cancer hsa-miR-222-3p FOXO3 1.08197052578759 2.32604040301699e-14 -0.326231432881512 0.00103053272543976 miRNAWalker2_validate;miRTarBase -0.10865194330018 0.000268712206928037 NA NA NA hsa-miR-29a-5p FOXO3 0.323252792625584 0.0370417231222825 -0.326231432881512 0.00103053272543976 mirMAP -0.192673250476205 2.35660686025332e-12 NA NA NA hsa-miR-29b-3p FOXO3 -0.110721443686039 0.511264554091106 -0.326231432881512 0.00103053272543976 miRNATAP -0.187934449867497 9.24714733778604e-14 NA NA NA hsa-miR-301a-3p FOXO3 2.14132004241926 4.46255413526808e-25 -0.326231432881512 0.00103053272543976 mirMAP -0.111966726503781 1.37013511404602e-08 NA NA NA hsa-miR-30c-5p FOXO3 0.021222006155897 0.886366656528128 -0.326231432881512 0.00103053272543976 miRNATAP -0.135924055762606 3.07635840214369e-06 NA NA NA hsa-miR-320a FOXO3 0.801356001806321 4.91397101474502e-09 -0.326231432881512 0.00103053272543976 miRNATAP -0.133376898343357 1.85982283161019e-05 NA NA NA hsa-miR-361-3p FOXO3 0.272298288982435 0.0147874880476998 -0.326231432881512 0.00103053272543976 miRNATAP -0.18848558150996 1.15614415255826e-06 NA NA NA hsa-miR-362-3p FOXO3 -0.697212068252854 2.61718493418184e-06 -0.326231432881512 0.00103053272543976 miRanda -0.104960859577398 0.000308756863810835 NA NA NA hsa-miR-450b-5p FOXO3 1.25529820885833 1.18847120528666e-15 -0.326231432881512 0.00103053272543976 miRNATAP -0.127591604987493 1.82392930732045e-06 NA NA NA hsa-miR-454-3p FOXO3 1.54137391927201 4.15861570449376e-20 -0.326231432881512 0.00103053272543976 mirMAP -0.166706717178168 9.26408933102215e-12 NA NA NA hsa-miR-542-3p FOXO3 0.643308814904977 8.81635403230104e-07 -0.326231432881512 0.00103053272543976 miRNATAP -0.137728337291912 2.68599987168984e-05 NA NA NA hsa-miR-576-5p FOXO3 0.940432050128373 6.90227595663302e-12 -0.326231432881512 0.00103053272543976 mirMAP -0.164933244160963 8.45615909924079e-08 NA NA NA hsa-miR-582-3p FOXO3 -0.248056267546012 0.143798829508405 -0.326231432881512 0.00103053272543976 PITA;miRNATAP -0.105758243064885 3.33901203538729e-05 NA NA NA hsa-miR-590-3p FOXO3 0.221436901462551 0.0965904764063157 -0.326231432881512 0.00103053272543976 PITA;miRanda;mirMAP;miRNATAP -0.160388762959494 7.56538519046171e-07 NA NA NA hsa-miR-590-5p FOXO3 0.763025362395968 3.65305892505623e-09 -0.326231432881512 0.00103053272543976 miRanda -0.153552738820751 3.18018267930044e-06 NA NA NA hsa-miR-664a-3p FOXO3 -0.256108763664991 0.0513188660751664 -0.326231432881512 0.00103053272543976 mirMAP -0.112602215558526 0.00066297696648861 NA NA NA hsa-miR-708-3p FOXO3 1.32647174389322 4.87465491977979e-16 -0.326231432881512 0.00103053272543976 miRNATAP -0.10041170901648 9.3883681975074e-05 NA NA NA hsa-miR-92a-3p FOXO3 0.994679542307232 1.32587679156217e-16 -0.326231432881512 0.00103053272543976 mirMAP -0.138744398056445 7.47541690221746e-05 NA NA NA hsa-miR-142-3p GHR 1.12754191614028 1.68798138028946e-08 -1.22528587755802 3.47302730555662e-06 MirTarget;PITA;miRanda;miRNATAP -0.297046937673111 1.67230931014283e-07 NA NA NA hsa-miR-15a-5p GHR 0.783550182002274 2.60699595655907e-11 -1.22528587755802 3.47302730555662e-06 MirTarget;miRNATAP -0.634531635641298 3.49495059386986e-11 NA NA NA hsa-miR-15b-5p GHR 0.85315666454713 3.79816274836297e-12 -1.22528587755802 3.47302730555662e-06 MirTarget;miRNATAP -0.384862680839798 3.21223863081852e-05 NA NA NA hsa-miR-16-2-3p GHR 1.1567130855258 1.01867256952189e-14 -1.22528587755802 3.47302730555662e-06 mirMAP -0.487914008383871 5.90046691387845e-11 NA NA NA hsa-miR-16-5p GHR 0.521122945828175 1.40561786410572e-06 -1.22528587755802 3.47302730555662e-06 MirTarget;miRNATAP -0.713465056923056 1.27093052279277e-11 NA NA NA hsa-miR-29a-5p GHR 0.323252792625584 0.0370417231222825 -1.22528587755802 3.47302730555662e-06 mirMAP;miRNATAP -0.334024001831373 7.4993228650486e-06 NA NA NA hsa-miR-3607-3p GHR 1.01377165357363 9.13355519701165e-05 -1.22528587755802 3.47302730555662e-06 mirMAP -0.190894420478056 1.64555470716258e-05 NA NA NA hsa-miR-424-5p GHR 1.48125289532143 9.10372985713165e-19 -1.22528587755802 3.47302730555662e-06 MirTarget;miRNATAP -0.279242524167786 2.83098480468168e-05 NA NA NA hsa-miR-429 GHR 0.559451508722375 0.00563641638673083 -1.22528587755802 3.47302730555662e-06 miRanda;miRNATAP -0.218676579937026 0.000129437279275675 NA NA NA hsa-miR-455-5p GHR 1.408595672323 5.52039116456697e-22 -1.22528587755802 3.47302730555662e-06 miRanda -0.263393172143474 0.000547678735223907 NA NA NA hsa-miR-590-3p GHR 0.221436901462551 0.0965904764063157 -1.22528587755802 3.47302730555662e-06 mirMAP -0.442773746054236 3.30359260287333e-07 NA NA NA hsa-miR-7-1-3p GHR 1.13646121619622 1.49823237535933e-14 -1.22528587755802 3.47302730555662e-06 MirTarget;mirMAP -0.40827457941604 7.52969488687425e-08 NA NA NA hsa-miR-101-3p GNB1 -1.91263766544878 1.50270129259053e-39 0.466100662558098 1.66131410872152e-13 miRNAWalker2_validate;MirTarget;miRNATAP -0.149843226273743 5.04613289999851e-18 NA NA NA hsa-miR-29b-2-5p GNB1 -0.502720326849742 0.000730448246894952 0.466100662558098 1.66131410872152e-13 MirTarget -0.111723664189568 1.7652356299577e-09 NA NA NA hsa-miR-331-3p GNB2 0.906385914819361 4.27653809739414e-11 -0.0468779773646908 0.580461880163829 miRNAWalker2_validate;MirTarget;PITA;miRNATAP -0.118882323574846 5.62695706398967e-06 NA NA NA hsa-miR-103a-2-5p GNB4 1.37988337975616 6.74852943995612e-08 0.434625394424438 0.00248777724987897 MirTarget -0.105234672923841 6.32453058987173e-05 NA NA NA hsa-miR-27b-3p GNB4 -0.732682718863563 2.26896143573324e-09 0.434625394424438 0.00248777724987897 miRNAWalker2_validate -0.152820931997841 0.00254495405670561 NA NA NA hsa-miR-29b-3p GNB4 -0.110721443686039 0.511264554091106 0.434625394424438 0.00248777724987897 MirTarget -0.148515606956927 6.47781002960341e-05 NA NA NA hsa-miR-361-5p GNB4 0.0803683277369505 0.314043140368058 0.434625394424438 0.00248777724987897 miRanda;miRNATAP -0.222317805979136 0.00548893142743628 NA NA NA hsa-miR-429 GNB4 0.559451508722375 0.00563641638673083 0.434625394424438 0.00248777724987897 miRanda -0.223803606524415 1.50861510159643e-13 NA NA NA hsa-miR-501-5p GNB4 1.02806906860218 1.63456814370548e-09 0.434625394424438 0.00248777724987897 mirMAP -0.142222550410317 0.000103910520130719 NA NA NA hsa-miR-93-5p GNB4 1.61042951896619 5.1280369606967e-24 0.434625394424438 0.00248777724987897 miRNAWalker2_validate -0.129799245257303 0.000553281290256018 NA NA NA hsa-miR-96-5p GNB4 1.42326703011157 4.39736150032373e-14 0.434625394424438 0.00248777724987897 MirTarget -0.222144687343025 2.98066618172876e-12 NA NA NA hsa-miR-128-3p GNB5 -0.170677254601174 0.20412808476528 0.917717395197355 1.50483049166727e-23 miRNAWalker2_validate -0.118666358355235 0.000135984838965614 NA NA NA hsa-miR-148a-3p GNB5 -0.428944290834563 0.00954246923521465 0.917717395197355 1.50483049166727e-23 miRNAWalker2_validate -0.116270378338527 3.46989962142575e-06 NA NA NA hsa-miR-217 GNB5 -1.35391381055929 2.42394951427902e-09 0.917717395197355 1.50483049166727e-23 miRanda -0.117399191669208 4.21140262907369e-11 NA NA NA hsa-miR-26b-5p GNB5 -0.254478038884324 0.0285227763044636 0.917717395197355 1.50483049166727e-23 miRNAWalker2_validate -0.173781332534163 1.25446729769197e-06 NA NA NA hsa-miR-338-3p GNB5 -0.948755228846395 8.99167125682392e-08 0.917717395197355 1.50483049166727e-23 miRanda -0.106355732896138 4.18448677150113e-06 NA NA NA hsa-miR-320b GNG11 1.23473838180754 3.04337566045537e-14 -0.457273781294273 0.00183160907075037 miRanda -0.224274401224359 3.59907165774881e-09 NA NA NA hsa-miR-140-5p GNG12 -0.412389003031485 0.000136051708543369 -0.229202139720909 0.0250475379704555 PITA;miRanda -0.134715839462402 0.0010850909223448 NA NA NA hsa-miR-28-5p GNG12 -0.026996999089909 0.733047113251652 -0.229202139720909 0.0250475379704555 PITA;miRanda -0.240049752558578 2.59100377532133e-05 NA NA NA hsa-miR-30d-3p GNG12 -0.577371911152798 2.02950840095287e-06 -0.229202139720909 0.0250475379704555 mirMAP -0.218992490146666 1.26213229239791e-09 NA NA NA hsa-miR-374a-5p GNG12 -0.621903385111545 6.61791773205282e-12 -0.229202139720909 0.0250475379704555 mirMAP -0.142652973262067 0.00340230327070474 NA NA NA hsa-miR-374b-5p GNG12 -0.288413933608091 0.0041474558664058 -0.229202139720909 0.0250475379704555 mirMAP -0.335371886812206 1.24401033850306e-14 NA NA NA hsa-miR-409-5p GNG12 0.491285368786351 0.0165413843067426 -0.229202139720909 0.0250475379704555 PITA -0.112255441775039 1.86101629997431e-07 NA NA NA hsa-miR-423-5p GNG12 0.60141781325829 1.62940950644999e-07 -0.229202139720909 0.0250475379704555 miRNAWalker2_validate -0.15452866245864 5.76708984314237e-05 NA NA NA hsa-miR-590-3p GNG12 0.221436901462551 0.0965904764063157 -0.229202139720909 0.0250475379704555 miRanda;mirMAP -0.109436768392884 0.00108913938845348 NA NA NA hsa-miR-590-5p GNG12 0.763025362395968 3.65305892505623e-09 -0.229202139720909 0.0250475379704555 PITA -0.162980782845926 1.42844920041051e-06 NA NA NA hsa-miR-96-5p GNG12 1.42326703011157 4.39736150032373e-14 -0.229202139720909 0.0250475379704555 TargetScan -0.119950329982978 1.45488060901013e-07 NA NA NA hsa-miR-30d-3p GNG2 -0.577371911152798 2.02950840095287e-06 0.153164603004257 0.379559786922516 mirMAP -0.16417366531823 0.00843494522705093 NA NA NA hsa-miR-324-5p GNG2 1.66709479707179 1.45961450445769e-23 0.153164603004257 0.379559786922516 miRanda -0.211723589048679 9.62118376757002e-07 NA NA NA hsa-miR-335-3p GNG2 0.336785882180547 0.0542446207938138 0.153164603004257 0.379559786922516 mirMAP -0.168959087446873 9.28594859552728e-05 NA NA NA hsa-miR-429 GNG2 0.559451508722375 0.00563641638673083 0.153164603004257 0.379559786922516 miRanda;miRNATAP -0.327211887971511 1.44221421172785e-19 NA NA NA hsa-miR-500a-5p GNG2 0.675401699376111 8.24389004707854e-05 0.153164603004257 0.379559786922516 mirMAP -0.136091490166989 0.00196751897553701 NA NA NA hsa-miR-590-5p GNG2 0.763025362395968 3.65305892505623e-09 0.153164603004257 0.379559786922516 miRanda;miRNATAP -0.312765363069043 5.12230023330908e-08 NA NA NA hsa-miR-944 GNG2 1.47323925060177 2.61626403984929e-13 0.153164603004257 0.379559786922516 mirMAP -0.232457598856729 1.32271495551851e-10 NA NA NA hsa-miR-142-5p GNG4 0.288897753038094 0.0900009317815725 -0.598998895927056 0.0295751028233577 mirMAP -0.270535796041951 0.000119973919699869 NA NA NA hsa-miR-342-3p GNG4 0.99756868977753 9.28499866272332e-10 -0.598998895927056 0.0295751028233577 mirMAP -0.195731240735478 0.00704735321746139 NA NA NA hsa-let-7a-5p GNG5 -0.439381775414001 3.1119785480023e-05 -0.0139855857337396 0.855320565842147 MirTarget;TargetScan;miRNATAP -0.169708149988811 5.48111263103411e-08 NA NA NA hsa-let-7b-5p GNG5 -0.2489842756826 0.0211384499461719 -0.0139855857337396 0.855320565842147 MirTarget;miRNATAP -0.135616252393189 1.07488334800303e-05 NA NA NA hsa-let-7e-5p GNG5 0.0857356192778891 0.512869729833211 -0.0139855857337396 0.855320565842147 miRNAWalker2_validate;MirTarget;miRNATAP -0.100445000782102 7.72458109567202e-05 NA NA NA hsa-miR-1271-5p GNG7 0.564681884899804 0.000425257395055278 -1.96928829336781 3.56688408795345e-19 mirMAP -0.192381861511945 0.00188423508760484 NA NA NA hsa-miR-141-3p GNG7 0.730011517758706 0.000120338355004032 -1.96928829336781 3.56688408795345e-19 MirTarget;TargetScan;miRNATAP -0.279002053512395 6.33254756334346e-08 NA NA NA hsa-miR-17-3p GNG7 -0.0127974722290336 0.909559935689875 -1.96928829336781 3.56688408795345e-19 mirMAP -0.306981069928375 0.000549461084972192 NA NA NA hsa-miR-181a-2-3p GNG7 0.562132917934234 4.79313448225408e-05 -1.96928829336781 3.56688408795345e-19 mirMAP -0.201681248291272 0.0049142002731587 NA NA NA hsa-miR-182-5p GNG7 1.15060905311096 6.25565852529946e-10 -1.96928829336781 3.56688408795345e-19 mirMAP -0.210592536921466 5.80269928123739e-05 NA NA NA hsa-miR-185-3p GNG7 0.653637407906201 6.54212996668668e-05 -1.96928829336781 3.56688408795345e-19 mirMAP -0.205880658285681 0.000654940753508538 NA NA NA hsa-miR-18a-3p GNG7 1.82583720936229 7.51297960972179e-19 -1.96928829336781 3.56688408795345e-19 mirMAP -0.393344501121379 2.50894162089134e-17 NA NA NA hsa-miR-18a-5p GNG7 1.65455873230328 3.76457892277775e-20 -1.96928829336781 3.56688408795345e-19 mirMAP -0.473993477190813 2.50553479714032e-20 NA NA NA hsa-miR-193b-5p GNG7 1.10486595354104 6.41489920661805e-11 -1.96928829336781 3.56688408795345e-19 mirMAP -0.442850003718459 3.76350255190172e-15 NA NA NA hsa-miR-200a-3p GNG7 0.607140814457753 0.00289840524858752 -1.96928829336781 3.56688408795345e-19 MirTarget;miRNATAP -0.130969832945733 0.00710530058072902 NA NA NA hsa-miR-22-5p GNG7 0.706731861922839 3.44318705980007e-07 -1.96928829336781 3.56688408795345e-19 mirMAP -0.377843403610421 8.29139480235812e-08 NA NA NA hsa-miR-224-5p GNG7 1.94534596857416 1.88348779207332e-19 -1.96928829336781 3.56688408795345e-19 mirMAP -0.415294565777656 2.01955887857522e-22 NA NA NA hsa-miR-23a-3p GNG7 0.348231698801568 6.4911858506572e-05 -1.96928829336781 3.56688408795345e-19 mirMAP -0.603865353508548 1.12455740362181e-07 NA NA NA hsa-miR-31-3p GNG7 2.10124531535908 1.70135756565194e-08 -1.96928829336781 3.56688408795345e-19 mirMAP -0.260502892268356 2.95714676798468e-25 NA NA NA hsa-miR-31-5p GNG7 2.79079137807505 1.72181058015659e-13 -1.96928829336781 3.56688408795345e-19 mirMAP -0.27004057657821 3.8876877168793e-28 NA NA NA hsa-miR-330-5p GNG7 0.944693925383906 5.04972895657346e-13 -1.96928829336781 3.56688408795345e-19 mirMAP -0.201234300748704 0.00700393165048644 NA NA NA hsa-miR-3614-5p GNG7 0.955957969488529 2.95347675446694e-05 -1.96928829336781 3.56688408795345e-19 mirMAP -0.131175927688257 0.00235872683316611 NA NA NA hsa-miR-3615 GNG7 0.761416334979744 9.83072409815373e-09 -1.96928829336781 3.56688408795345e-19 mirMAP -0.258176057685396 0.000482601354399127 NA NA NA hsa-miR-671-5p GNG7 1.90920358947989 6.8158317757852e-31 -1.96928829336781 3.56688408795345e-19 mirMAP -0.419016918070274 3.92972470656425e-14 NA NA NA hsa-miR-92a-3p GNG7 0.994679542307232 1.32587679156217e-16 -1.96928829336781 3.56688408795345e-19 miRNAWalker2_validate -0.587398977704882 9.08481842165774e-14 NA NA NA hsa-miR-939-5p GNG7 1.00479167005165 2.93105661166695e-09 -1.96928829336781 3.56688408795345e-19 mirMAP -0.291763330715998 1.45707229488921e-06 NA NA NA hsa-miR-940 GNG7 1.25303020594374 1.3005368359451e-10 -1.96928829336781 3.56688408795345e-19 MirTarget -0.226445914826704 7.12097382175534e-06 NA NA NA hsa-miR-96-5p GNG7 1.42326703011157 4.39736150032373e-14 -1.96928829336781 3.56688408795345e-19 mirMAP -0.3277424570507 9.4044996581757e-11 NA NA NA hsa-miR-219a-1-3p GNGT2 0.54812960890496 0.000643480374673536 0.32070763940756 0.0862832347649647 MirTarget -0.21755454573517 1.57683627840316e-05 NA NA NA hsa-miR-146b-5p GSK3B 0.917975986853978 3.33749259316025e-09 0.343238217842623 0.000162620715851218 miRanda -0.132473733778903 1.22425435698654e-07 NA NA NA hsa-miR-155-5p GSK3B 0.533437622040649 0.00248671179205372 0.343238217842623 0.000162620715851218 miRNAWalker2_validate;miRNATAP -0.129703405382586 5.34297193283262e-09 NA NA NA hsa-miR-181a-5p GSK3B 0.819060835827404 1.38616688310277e-13 0.343238217842623 0.000162620715851218 mirMAP -0.129983989338606 0.00022139654686707 NA NA NA hsa-miR-181c-5p GSK3B -0.168991199007857 0.196949106150297 0.343238217842623 0.000162620715851218 mirMAP -0.100996413243857 0.000916035275097975 NA NA NA hsa-miR-19b-3p GSK3B 0.538732279378089 0.000622008277870679 0.343238217842623 0.000162620715851218 mirMAP -0.150537422390616 1.39629849063498e-09 NA NA NA hsa-miR-26b-5p GSK3B -0.254478038884324 0.0285227763044636 0.343238217842623 0.000162620715851218 miRNATAP -0.183171373213342 7.56842885965509e-08 NA NA NA hsa-miR-29b-3p GSK3B -0.110721443686039 0.511264554091106 0.343238217842623 0.000162620715851218 miRTarBase;miRNATAP -0.15553953034104 2.18389788804596e-11 NA NA NA hsa-miR-30d-3p GSK3B -0.577371911152798 2.02950840095287e-06 0.343238217842623 0.000162620715851218 miRNATAP -0.131426620771029 5.32900605744827e-05 NA NA NA hsa-miR-320a GSK3B 0.801356001806321 4.91397101474502e-09 0.343238217842623 0.000162620715851218 miRanda;mirMAP -0.118878412659656 3.17737768709188e-05 NA NA NA hsa-miR-342-3p GSK3B 0.99756868977753 9.28499866272332e-10 0.343238217842623 0.000162620715851218 miRanda -0.148362741070108 3.75779017463144e-10 NA NA NA hsa-miR-362-5p GSK3B 0.41089772861323 0.0404254902071382 0.343238217842623 0.000162620715851218 miRNATAP -0.127816847863223 5.47709912360141e-11 NA NA NA hsa-miR-374a-5p GSK3B -0.621903385111545 6.61791773205282e-12 0.343238217842623 0.000162620715851218 mirMAP -0.147719372342419 0.000672011632138884 NA NA NA hsa-miR-374b-5p GSK3B -0.288413933608091 0.0041474558664058 0.343238217842623 0.000162620715851218 mirMAP -0.228003781574329 6.67084161350237e-09 NA NA NA hsa-miR-664a-3p GSK3B -0.256108763664991 0.0513188660751664 0.343238217842623 0.000162620715851218 mirMAP -0.163651290979419 5.20958641528547e-08 NA NA NA hsa-miR-320b GYS1 1.23473838180754 3.04337566045537e-14 -0.301813299026298 0.00135710535152544 miRanda -0.109327375343448 8.3277198854826e-06 NA NA NA hsa-miR-423-5p GYS1 0.60141781325829 1.62940950644999e-07 -0.301813299026298 0.00135710535152544 MirTarget -0.114872467983221 0.0012333195331769 NA NA NA hsa-miR-429 GYS1 0.559451508722375 0.00563641638673083 -0.301813299026298 0.00135710535152544 miRNATAP -0.1032255956185 2.83630083749495e-07 NA NA NA hsa-miR-146b-5p GYS2 0.917975986853978 3.33749259316025e-09 -4.56795349756871 8.46213143375979e-36 miRanda -0.410752065478478 0.000153983102283324 NA NA NA hsa-miR-542-3p GYS2 0.643308814904977 8.81635403230104e-07 -4.56795349756871 8.46213143375979e-36 miRanda -0.448895526166825 0.000545217771025678 NA NA NA hsa-miR-625-5p GYS2 0.346770617079364 0.02860843739549 -4.56795349756871 8.46213143375979e-36 MirTarget -0.34699131961467 0.00141870801124911 NA NA NA hsa-let-7a-3p HGF 0.0966652362351867 0.423761916840503 -0.628808099278418 0.0248850412356301 mirMAP -0.678925182790585 1.16230629525026e-11 NA NA NA hsa-miR-141-3p HGF 0.730011517758706 0.000120338355004032 -0.628808099278418 0.0248850412356301 MirTarget;TargetScan -0.561125900874801 1.20618910138091e-19 NA NA NA hsa-miR-200a-3p HGF 0.607140814457753 0.00289840524858752 -0.628808099278418 0.0248850412356301 MirTarget -0.46418885165035 1.63121170062695e-15 NA NA NA hsa-miR-203a-3p HGF 0.0441399794719697 0.880456392176704 -0.628808099278418 0.0248850412356301 MirTarget -0.321186869823737 2.52059425443943e-15 NA NA NA hsa-miR-224-3p HGF 0.502645536188015 0.0081142387260641 -0.628808099278418 0.0248850412356301 mirMAP -0.382701156821044 2.14724084930058e-09 NA NA NA hsa-miR-26b-5p HGF -0.254478038884324 0.0285227763044636 -0.628808099278418 0.0248850412356301 MirTarget;miRNATAP -0.293463586038775 0.00556150652071372 NA NA NA hsa-miR-29a-5p HGF 0.323252792625584 0.0370417231222825 -0.628808099278418 0.0248850412356301 mirMAP -0.33517175543393 2.02072168292234e-05 NA NA NA hsa-miR-30b-5p HGF -0.400238605368173 0.00346540992719245 -0.628808099278418 0.0248850412356301 mirMAP -0.339568782547391 0.000139133814424322 NA NA NA hsa-miR-30c-5p HGF 0.021222006155897 0.886366656528128 -0.628808099278418 0.0248850412356301 mirMAP -0.364505623339003 9.30153464059718e-06 NA NA NA hsa-miR-33a-3p HGF 0.20371038027126 0.212335697664505 -0.628808099278418 0.0248850412356301 mirMAP -0.245106862650746 0.0012734452978666 NA NA NA hsa-miR-429 HGF 0.559451508722375 0.00563641638673083 -0.628808099278418 0.0248850412356301 miRanda -0.406558130985217 6.89356985764421e-12 NA NA NA hsa-miR-590-5p HGF 0.763025362395968 3.65305892505623e-09 -0.628808099278418 0.0248850412356301 miRanda -0.578847824892088 3.36079943237795e-10 NA NA NA hsa-miR-651-5p HGF 0.504713329111777 0.00155970216047171 -0.628808099278418 0.0248850412356301 MirTarget -0.32162676958462 2.46985420767702e-05 NA NA NA hsa-miR-7-1-3p HGF 1.13646121619622 1.49823237535933e-14 -0.628808099278418 0.0248850412356301 mirMAP -0.279818488965689 0.000518564555493889 NA NA NA hsa-miR-944 HGF 1.47323925060177 2.61626403984929e-13 -0.628808099278418 0.0248850412356301 mirMAP -0.331250406167246 1.57938016792516e-08 NA NA NA hsa-let-7a-5p HRAS -0.439381775414001 3.1119785480023e-05 0.26280245681614 0.0556242904507885 miRNAWalker2_validate;miRTarBase -0.301645525492195 8.02100955354543e-08 20607356;23134218;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;;progression glioblastoma;lung squamous cell cancer;lung cancer;lung cancer;pancreatic cancer hsa-let-7b-5p HRAS -0.2489842756826 0.0211384499461719 0.26280245681614 0.0556242904507885 miRTarBase -0.216577181164546 9.6758212516064e-05 20607356;20881268;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;On the basis of these data we suggest that the downregulation of let-7b and let-7e targeting K-ras and the upregulation of miR-17* a CRC marker could be considered as candidate molecular markers of cetuximab resistance;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;drug resistance;;;progression glioblastoma;colorectal cancer;lung cancer;lung cancer;pancreatic cancer hsa-miR-143-3p HRAS -1.33760181792708 4.15335119989612e-12 0.26280245681614 0.0556242904507885 miRNAWalker2_validate;miRTarBase -0.249594509349032 2.27678793354297e-17 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-181d-5p HRAS 0.367649966373544 0.00537300571455306 0.26280245681614 0.0556242904507885 miRNAWalker2_validate;miRTarBase -0.122856153096347 0.00677992276763114 NA NA NA hsa-miR-30e-5p HSP90AA1 -1.02114836019762 6.81961221797866e-17 0.409133961897396 4.56120389131578e-06 miRNAWalker2_validate -0.201709935581509 4.52870506024666e-11 NA NA NA hsa-miR-139-5p IBSP -1.46099200329485 7.85040381494472e-22 3.99296450803786 2.88953064495749e-28 miRanda -0.679846719727307 5.45959597060094e-11 NA NA NA hsa-miR-26b-5p IBSP -0.254478038884324 0.0285227763044636 3.99296450803786 2.88953064495749e-28 miRNAWalker2_validate -0.605240365839627 2.54783529446726e-05 NA NA NA hsa-miR-141-3p IFNAR2 0.730011517758706 0.000120338355004032 0.421649896532006 6.88352600382185e-06 mirMAP -0.104709037647682 9.5153496516924e-07 NA NA NA hsa-let-7a-3p IGF1 0.0966652362351867 0.423761916840503 -1.83606554417213 4.89445874007951e-10 mirMAP -0.628414381189287 5.27761426031282e-09 NA NA NA hsa-miR-103a-2-5p IGF1 1.37988337975616 6.74852943995612e-08 -1.83606554417213 4.89445874007951e-10 mirMAP -0.45438875584609 1.7540230331713e-17 NA NA NA hsa-miR-130a-3p IGF1 0.67051191119964 4.89747518735144e-06 -1.83606554417213 4.89445874007951e-10 MirTarget -0.700417159997035 4.55001564446877e-16 NA NA NA hsa-miR-130b-3p IGF1 1.44628430084411 9.13980959861273e-24 -1.83606554417213 4.89445874007951e-10 MirTarget -0.381225145442848 1.06880616791146e-05 NA NA NA hsa-miR-15b-3p IGF1 1.05020782493504 6.38723677324836e-14 -1.83606554417213 4.89445874007951e-10 mirMAP -0.600110692355124 2.35788363622271e-11 NA NA NA hsa-miR-16-1-3p IGF1 0.955017760172879 5.95379292601146e-11 -1.83606554417213 4.89445874007951e-10 mirMAP -0.654262965462375 3.52738431783344e-14 NA NA NA hsa-miR-186-5p IGF1 0.353452958261612 0.000145058448579496 -1.83606554417213 4.89445874007951e-10 mirMAP -0.366692143669484 0.00959838552779203 NA NA NA hsa-miR-19a-3p IGF1 1.35800152353624 2.80940447111944e-12 -1.83606554417213 4.89445874007951e-10 MirTarget -0.675360942734142 3.91550460498543e-27 NA NA NA hsa-miR-19b-1-5p IGF1 0.757034032029085 2.99828133413343e-07 -1.83606554417213 4.89445874007951e-10 mirMAP -0.699245326551041 2.59396405008731e-16 NA NA NA hsa-miR-19b-3p IGF1 0.538732279378089 0.000622008277870679 -1.83606554417213 4.89445874007951e-10 MirTarget -0.750279055807441 5.4834038782256e-21 NA NA NA hsa-miR-205-3p IGF1 1.2960640797621 5.80786479909147e-11 -1.83606554417213 4.89445874007951e-10 mirMAP -0.600295652502196 5.84026535331867e-22 NA NA NA hsa-miR-20a-3p IGF1 1.34885093664027 2.07697464119202e-12 -1.83606554417213 4.89445874007951e-10 mirMAP -0.573755673684406 5.83753051386334e-19 NA NA NA hsa-miR-224-3p IGF1 0.502645536188015 0.0081142387260641 -1.83606554417213 4.89445874007951e-10 mirMAP -0.397083320323672 6.59448390538765e-09 NA NA NA hsa-miR-27a-3p IGF1 0.348456440505425 0.00126682892514312 -1.83606554417213 4.89445874007951e-10 miRNAWalker2_validate;miRTarBase -0.630796790452773 1.61575924809895e-07 NA NA NA hsa-miR-301a-3p IGF1 2.14132004241926 4.46255413526808e-25 -1.83606554417213 4.89445874007951e-10 MirTarget -0.542962161756586 7.28279283702467e-21 NA NA NA hsa-miR-320a IGF1 0.801356001806321 4.91397101474502e-09 -1.83606554417213 4.89445874007951e-10 miRNATAP -0.471166482627833 4.87790750232857e-07 NA NA NA hsa-miR-320b IGF1 1.23473838180754 3.04337566045537e-14 -1.83606554417213 4.89445874007951e-10 miRNATAP -0.435970586012069 1.99260325159595e-08 NA NA NA hsa-miR-33a-3p IGF1 0.20371038027126 0.212335697664505 -1.83606554417213 4.89445874007951e-10 MirTarget -0.301086727433913 0.000210494168325812 NA NA NA hsa-miR-3607-3p IGF1 1.01377165357363 9.13355519701165e-05 -1.83606554417213 4.89445874007951e-10 mirMAP -0.279152595145872 1.84181237021726e-08 NA NA NA hsa-miR-362-5p IGF1 0.41089772861323 0.0404254902071382 -1.83606554417213 4.89445874007951e-10 mirMAP -0.266319117984938 4.10437106471054e-05 NA NA NA hsa-miR-450b-5p IGF1 1.25529820885833 1.18847120528666e-15 -1.83606554417213 4.89445874007951e-10 MirTarget;PITA;mirMAP;miRNATAP -0.248366118573042 0.00221127559765416 NA NA NA hsa-miR-452-5p IGF1 0.373288744398455 0.0348485937209964 -1.83606554417213 4.89445874007951e-10 MirTarget;mirMAP -0.266246297258034 0.000308015705405959 NA NA NA hsa-miR-454-3p IGF1 1.54137391927201 4.15861570449376e-20 -1.83606554417213 4.89445874007951e-10 MirTarget -0.626033221014056 8.04576753877952e-18 NA NA NA hsa-miR-576-5p IGF1 0.940432050128373 6.90227595663302e-12 -1.83606554417213 4.89445874007951e-10 PITA;mirMAP;miRNATAP -0.73695380930135 6.7749669820951e-16 NA NA NA hsa-miR-590-3p IGF1 0.221436901462551 0.0965904764063157 -1.83606554417213 4.89445874007951e-10 MirTarget;miRanda;mirMAP;miRNATAP -0.293536383987437 0.00288981376091861 NA NA NA hsa-miR-629-5p IGF1 0.461215538037447 8.95262667860215e-06 -1.83606554417213 4.89445874007951e-10 mirMAP -0.473288980212107 0.00016595454212857 NA NA NA hsa-miR-940 IGF1 1.25303020594374 1.3005368359451e-10 -1.83606554417213 4.89445874007951e-10 MirTarget;PITA;miRNATAP -0.179832112337034 0.00706374566547861 NA NA NA hsa-let-7g-5p IGF1R -0.250780249469264 0.00939610188330072 0.658946603715235 3.61776569897156e-07 MirTarget;miRNATAP -0.155732549646198 0.00895625538301226 NA NA NA hsa-miR-125a-5p IGF1R 0.215366061934933 0.119550904549401 0.658946603715235 3.61776569897156e-07 mirMAP -0.122652006063788 0.00300283808252089 NA NA NA hsa-miR-125b-5p IGF1R -0.993460109818276 5.07736727659894e-12 0.658946603715235 3.61776569897156e-07 mirMAP -0.115202680031871 0.00303906338889069 NA NA NA hsa-miR-139-5p IGF1R -1.46099200329485 7.85040381494472e-22 0.658946603715235 3.61776569897156e-07 miRNAWalker2_validate;miRTarBase;MirTarget;PITA -0.147245183735145 3.99004378002884e-05 26097570 Furthermore we identified insulin-like growth factor 1 receptor IGF1R as a target of miR-139-5p and miR-139-5p function as a tumor suppressor via targeting IGF1R in NSCLC; Our results indicated that miR-139-5p acts as a tumor suppressor in NSCLC partially via down-regulating IGF1R expression lung squamous cell cancer hsa-miR-140-3p IGF1R -0.967453553824782 7.6999446305445e-23 0.658946603715235 3.61776569897156e-07 mirMAP -0.196835213061393 0.000425535569554514 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-140-5p IGF1R -0.412389003031485 0.000136051708543369 0.658946603715235 3.61776569897156e-07 PITA;miRNATAP -0.223557474307117 2.1291855472217e-05 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-146b-5p IGF1R 0.917975986853978 3.33749259316025e-09 0.658946603715235 3.61776569897156e-07 miRanda -0.122104654410604 0.00073816915030413 NA NA NA hsa-miR-150-5p IGF1R -0.243749814009231 0.331546276920338 0.658946603715235 3.61776569897156e-07 mirMAP -0.142756661920241 1.67670626260167e-10 NA NA NA hsa-miR-155-5p IGF1R 0.533437622040649 0.00248671179205372 0.658946603715235 3.61776569897156e-07 mirMAP -0.224562941255931 1.20598024492178e-12 NA NA NA hsa-miR-15a-5p IGF1R 0.783550182002274 2.60699595655907e-11 0.658946603715235 3.61776569897156e-07 miRNATAP -0.237899859491516 5.31568322470779e-07 NA NA NA hsa-miR-16-1-3p IGF1R 0.955017760172879 5.95379292601146e-11 0.658946603715235 3.61776569897156e-07 mirMAP -0.116704120509115 0.00242672527225861 NA NA NA hsa-miR-186-5p IGF1R 0.353452958261612 0.000145058448579496 0.658946603715235 3.61776569897156e-07 mirMAP -0.20597527734222 0.000818139228888561 NA NA NA hsa-miR-19a-3p IGF1R 1.35800152353624 2.80940447111944e-12 0.658946603715235 3.61776569897156e-07 mirMAP -0.112424087845666 8.44172640684963e-05 NA NA NA hsa-miR-29a-5p IGF1R 0.323252792625584 0.0370417231222825 0.658946603715235 3.61776569897156e-07 miRNATAP -0.137318447004994 0.000183839216350161 NA NA NA hsa-miR-29b-2-5p IGF1R -0.502720326849742 0.000730448246894952 0.658946603715235 3.61776569897156e-07 mirMAP -0.264948480596983 1.56682091635764e-12 NA NA NA hsa-miR-29b-3p IGF1R -0.110721443686039 0.511264554091106 0.658946603715235 3.61776569897156e-07 mirMAP -0.254632632247586 1.39236690585097e-14 NA NA NA hsa-miR-29c-3p IGF1R -2.08166260448948 8.3238369390898e-24 0.658946603715235 3.61776569897156e-07 mirMAP -0.111585311418395 2.00656321961855e-05 NA NA NA hsa-miR-30a-5p IGF1R -1.79779915425811 1.93360169837799e-26 0.658946603715235 3.61776569897156e-07 miRNAWalker2_validate;mirMAP;miRNATAP -0.183683218204462 6.72293627860893e-09 26025408 MiR 30a suppresses non small cell lung cancer progression through AKT signaling pathway by targeting IGF1R progression lung squamous cell cancer hsa-miR-30b-5p IGF1R -0.400238605368173 0.00346540992719245 0.658946603715235 3.61776569897156e-07 mirMAP -0.25107831096127 9.89527887529752e-10 NA NA NA hsa-miR-30c-5p IGF1R 0.021222006155897 0.886366656528128 0.658946603715235 3.61776569897156e-07 mirMAP;miRNATAP -0.244015878253709 1.23951540420282e-10 NA NA NA hsa-miR-30d-5p IGF1R -0.38399848121878 0.000171129616944749 0.658946603715235 3.61776569897156e-07 mirMAP;miRNATAP -0.201059970637282 0.000318689995409976 NA NA NA hsa-miR-30e-5p IGF1R -1.02114836019762 6.81961221797866e-17 0.658946603715235 3.61776569897156e-07 mirMAP -0.286483274229708 1.43613898306972e-10 NA NA NA hsa-miR-320a IGF1R 0.801356001806321 4.91397101474502e-09 0.658946603715235 3.61776569897156e-07 miRNAWalker2_validate;PITA;mirMAP;miRNATAP -0.12353574596143 0.0026605822492909 NA NA NA hsa-miR-342-3p IGF1R 0.99756868977753 9.28499866272332e-10 0.658946603715235 3.61776569897156e-07 mirMAP -0.23145563539146 7.79737236924884e-12 NA NA NA hsa-miR-342-5p IGF1R 0.862385578881784 1.60007936373305e-08 0.658946603715235 3.61776569897156e-07 mirMAP -0.202277416833612 3.0388946126467e-08 NA NA NA hsa-miR-34a-5p IGF1R -0.117372471043915 0.364001947180738 0.658946603715235 3.61776569897156e-07 miRNAWalker2_validate -0.311787067279754 6.87826334266983e-13 NA NA NA hsa-miR-362-3p IGF1R -0.697212068252854 2.61718493418184e-06 0.658946603715235 3.61776569897156e-07 PITA -0.168307563103232 1.00229822371416e-05 NA NA NA hsa-miR-374a-5p IGF1R -0.621903385111545 6.61791773205282e-12 0.658946603715235 3.61776569897156e-07 mirMAP -0.16988335502384 0.0064642031028813 NA NA NA hsa-miR-374b-5p IGF1R -0.288413933608091 0.0041474558664058 0.658946603715235 3.61776569897156e-07 mirMAP -0.222283776754656 9.22433274038686e-05 NA NA NA hsa-miR-497-5p IGF1R -0.966244470847844 5.26505649147857e-12 0.658946603715235 3.61776569897156e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.132785924595479 0.000876505984752571 NA NA NA hsa-miR-500a-3p IGF1R 0.457959128173392 0.000691656736597067 0.658946603715235 3.61776569897156e-07 mirMAP -0.289000053170829 2.94945339306885e-12 NA NA NA hsa-miR-532-5p IGF1R -0.021857649390892 0.830992272120134 0.658946603715235 3.61776569897156e-07 miRNATAP -0.200326248020098 0.000356759068484248 NA NA NA hsa-miR-130a-3p IGF2 0.67051191119964 4.89747518735144e-06 0.130732308478005 0.606612547963814 mirMAP -0.324538284523359 1.3160813634391e-05 NA NA NA hsa-miR-141-3p IGF2 0.730011517758706 0.000120338355004032 0.130732308478005 0.606612547963814 MirTarget;TargetScan -0.430572541444147 2.6570976244206e-14 NA NA NA hsa-miR-148a-3p IGF2 -0.428944290834563 0.00954246923521465 0.130732308478005 0.606612547963814 mirMAP -0.247562333397005 0.00020022997586927 NA NA NA hsa-miR-148b-3p IGF2 0.386859166050437 4.6728211830726e-06 0.130732308478005 0.606612547963814 mirMAP -0.815373978565952 3.20305506500657e-10 NA NA NA hsa-miR-150-5p IGF2 -0.243749814009231 0.331546276920338 0.130732308478005 0.606612547963814 miRNAWalker2_validate -0.13360557433827 0.00238685938902513 NA NA NA hsa-miR-192-5p IGF2 0.380924502586635 0.00986961967409205 0.130732308478005 0.606612547963814 mirMAP -0.474719611528428 1.21693916595116e-10 NA NA NA hsa-miR-193a-3p IGF2 0.22120710726779 0.111827069464729 0.130732308478005 0.606612547963814 mirMAP -0.235190560615962 0.00316740702451148 NA NA NA hsa-miR-19a-3p IGF2 1.35800152353624 2.80940447111944e-12 0.130732308478005 0.606612547963814 mirMAP -0.307472958113455 2.3133912535587e-08 NA NA NA hsa-miR-19b-3p IGF2 0.538732279378089 0.000622008277870679 0.130732308478005 0.606612547963814 mirMAP -0.429363302728369 4.95114367701055e-10 NA NA NA hsa-miR-200a-3p IGF2 0.607140814457753 0.00289840524858752 0.130732308478005 0.606612547963814 MirTarget -0.376609229788577 1.16212138455988e-12 NA NA NA hsa-miR-210-3p IGF2 3.16015094635767 4.37095019705785e-31 0.130732308478005 0.606612547963814 MirTarget -0.218127501529348 6.72778440957983e-09 NA NA NA hsa-miR-224-3p IGF2 0.502645536188015 0.0081142387260641 0.130732308478005 0.606612547963814 mirMAP -0.18239543191048 0.00181791082798036 NA NA NA hsa-miR-23a-5p IGF2 1.662156284689 7.34844237202118e-15 0.130732308478005 0.606612547963814 MirTarget -0.24283012664811 1.65622668182056e-06 NA NA NA hsa-miR-23b-5p IGF2 0.141208007066527 0.420202986869364 0.130732308478005 0.606612547963814 MirTarget -0.337179225699117 1.78808920024544e-07 NA NA NA hsa-miR-301a-3p IGF2 2.14132004241926 4.46255413526808e-25 0.130732308478005 0.606612547963814 mirMAP -0.190498569164423 0.000170950020883423 NA NA NA hsa-miR-31-5p IGF2 2.79079137807505 1.72181058015659e-13 0.130732308478005 0.606612547963814 mirMAP -0.125119744160946 1.23317042063549e-05 NA NA NA hsa-miR-339-5p IGF2 1.07771430326938 2.45772601859307e-09 0.130732308478005 0.606612547963814 mirMAP -0.332729784750595 2.36920833741934e-08 NA NA NA hsa-miR-342-5p IGF2 0.862385578881784 1.60007936373305e-08 0.130732308478005 0.606612547963814 MirTarget;mirMAP;miRNATAP -0.315934392774269 9.06374793058564e-06 NA NA NA hsa-miR-34a-5p IGF2 -0.117372471043915 0.364001947180738 0.130732308478005 0.606612547963814 mirMAP -0.347400380241615 4.93699500037352e-05 NA NA NA hsa-miR-361-3p IGF2 0.272298288982435 0.0147874880476998 0.130732308478005 0.606612547963814 mirMAP -0.460050658130368 3.2519479752365e-06 NA NA NA hsa-miR-454-3p IGF2 1.54137391927201 4.15861570449376e-20 0.130732308478005 0.606612547963814 mirMAP -0.341063238529512 5.62028286180104e-08 NA NA NA hsa-miR-93-5p IGF2 1.61042951896619 5.1280369606967e-24 0.130732308478005 0.606612547963814 miRNAWalker2_validate -0.26769917639849 5.05900818706672e-05 NA NA NA hsa-miR-125a-3p IKBKB 0.116035800853173 0.444825559956959 -0.396740795566287 2.1815201064403e-05 miRanda -0.108503103251697 5.57509033653017e-05 NA NA NA hsa-miR-151a-3p IKBKB 0.131002217498676 0.295273522160941 -0.396740795566287 2.1815201064403e-05 miRNAWalker2_validate -0.104928278750609 0.00139735412928447 NA NA NA hsa-miR-542-3p IKBKB 0.643308814904977 8.81635403230104e-07 -0.396740795566287 2.1815201064403e-05 miRanda -0.164952079150207 8.30758678680247e-08 NA NA NA hsa-miR-107 IKBKG -0.0447040564279497 0.671618791096755 0.570547337190534 1.55778741154943e-10 miRanda -0.193473702960341 2.35749871093699e-07 NA NA NA hsa-miR-143-3p IKBKG -1.33760181792708 4.15335119989612e-12 0.570547337190534 1.55778741154943e-10 mirMAP -0.136024640433278 4.28001868046101e-12 NA NA NA hsa-miR-338-5p IKBKG -1.71946558699173 2.62649071488641e-23 0.570547337190534 1.55778741154943e-10 mirMAP -0.122404174241048 1.41142850944174e-08 NA NA NA hsa-miR-199b-5p IL2RA -1.08432682485992 7.68241801134089e-10 1.64995620609536 3.01415367709319e-13 miRanda -0.224399122351766 6.46576537902014e-05 NA NA NA hsa-miR-224-3p IL2RA 0.502645536188015 0.0081142387260641 1.64995620609536 3.01415367709319e-13 MirTarget -0.19680158896281 0.000224088346292478 NA NA NA hsa-miR-3065-3p IL2RA -0.543069092777161 0.0213164885178151 1.64995620609536 3.01415367709319e-13 MirTarget -0.306455409147719 2.26068282981825e-13 NA NA NA hsa-miR-375 IL2RA -4.24070205340868 7.48368361454041e-28 1.64995620609536 3.01415367709319e-13 miRanda -0.178954859476608 1.02371510725154e-13 NA NA NA hsa-miR-125a-5p IL2RB 0.215366061934933 0.119550904549401 0.46694737201397 0.0313292505714046 miRanda -0.22311321687513 0.00113345274921199 NA NA NA hsa-miR-145-5p IL2RB -0.46917511594055 0.000685297625493134 0.46694737201397 0.0313292505714046 mirMAP -0.263756357761351 0.000109679838824784 NA NA NA hsa-miR-299-5p IL2RB -1.92445654064493 1.52402531359074e-16 0.46694737201397 0.0313292505714046 mirMAP -0.128864808127416 0.00107831713995579 NA NA NA hsa-miR-199a-5p IL4R -0.364835768178638 0.0435119211101981 0.235292415840093 0.0918561844265687 miRNATAP -0.10472059568867 0.00183087225916112 NA NA NA hsa-miR-217 IL4R -1.35391381055929 2.42394951427902e-09 0.235292415840093 0.0918561844265687 miRanda -0.135326204754466 2.19312199549138e-07 NA NA NA hsa-miR-491-5p IL4R -0.541680329196715 0.00135829217561865 0.235292415840093 0.0918561844265687 miRanda -0.173123087941089 3.47228894406629e-06 NA NA NA hsa-miR-361-5p IL6 0.0803683277369505 0.314043140368058 -1.04839267298997 0.0016427378053848 miRanda -0.543676267944881 0.00342457947633898 NA NA NA hsa-miR-429 IL6 0.559451508722375 0.00563641638673083 -1.04839267298997 0.0016427378053848 miRanda -0.394149454338654 2.99901296473304e-08 NA NA NA hsa-miR-103a-2-5p IL6R 1.37988337975616 6.74852943995612e-08 -0.0486500175487801 0.809389037083792 mirMAP -0.210431778055292 8.07930168735818e-09 NA NA NA hsa-miR-106a-5p IL6R 0.67978010057847 0.00221925869726092 -0.0486500175487801 0.809389037083792 mirMAP -0.207404631611843 1.0249352303409e-07 NA NA NA hsa-miR-125a-5p IL6R 0.215366061934933 0.119550904549401 -0.0486500175487801 0.809389037083792 MirTarget;miRanda -0.402717109339623 1.30969889036748e-10 NA NA NA hsa-miR-125b-5p IL6R -0.993460109818276 5.07736727659894e-12 -0.0486500175487801 0.809389037083792 miRTarBase;MirTarget -0.224605478876623 0.000168441856363728 22942733 The ectopic expression of miR-125b reduced the cellular proliferation and cell cycle progression of HCC cells by targeting Mcl-1 and IL6R progression liver cancer hsa-miR-130a-3p IL6R 0.67051191119964 4.89747518735144e-06 -0.0486500175487801 0.809389037083792 mirMAP -0.291535575619973 7.73164538793701e-07 NA NA NA hsa-miR-135b-5p IL6R 1.5570143078477 4.60753610971455e-13 -0.0486500175487801 0.809389037083792 mirMAP -0.106216670329152 0.00768110389353497 NA NA NA hsa-miR-141-3p IL6R 0.730011517758706 0.000120338355004032 -0.0486500175487801 0.809389037083792 MirTarget -0.207689091678661 5.52124490800715e-06 NA NA NA hsa-miR-146b-5p IL6R 0.917975986853978 3.33749259316025e-09 -0.0486500175487801 0.809389037083792 miRanda -0.157850889636848 0.00467164876145446 NA NA NA hsa-miR-155-5p IL6R 0.533437622040649 0.00248671179205372 -0.0486500175487801 0.809389037083792 MirTarget -0.15237980071983 0.00213783871461113 NA NA NA hsa-miR-17-5p IL6R 1.41924888736771 2.75805544953758e-18 -0.0486500175487801 0.809389037083792 mirMAP -0.226751100466577 1.25028986887258e-05 NA NA NA hsa-miR-182-5p IL6R 1.15060905311096 6.25565852529946e-10 -0.0486500175487801 0.809389037083792 mirMAP -0.143065481809668 0.00203379307788197 NA NA NA hsa-miR-186-5p IL6R 0.353452958261612 0.000145058448579496 -0.0486500175487801 0.809389037083792 mirMAP -0.406198626543001 1.70086573072698e-05 NA NA NA hsa-miR-192-5p IL6R 0.380924502586635 0.00986961967409205 -0.0486500175487801 0.809389037083792 mirMAP -0.206425553709301 0.000508804045128702 NA NA NA hsa-miR-197-3p IL6R 0.878693269130833 3.84847526014135e-15 -0.0486500175487801 0.809389037083792 MirTarget -0.205600134792494 0.00750031892225504 NA NA NA hsa-miR-200a-3p IL6R 0.607140814457753 0.00289840524858752 -0.0486500175487801 0.809389037083792 MirTarget -0.211507618263558 6.79944513522847e-07 NA NA NA hsa-miR-20a-5p IL6R 1.1531986665452 1.02385132917958e-11 -0.0486500175487801 0.809389037083792 mirMAP -0.292895025834035 5.22283508164814e-09 NA NA NA hsa-miR-20b-5p IL6R 0.345967670847176 0.232014828043601 -0.0486500175487801 0.809389037083792 mirMAP -0.231547507176398 4.77534103525254e-15 NA NA NA hsa-miR-29a-5p IL6R 0.323252792625584 0.0370417231222825 -0.0486500175487801 0.809389037083792 mirMAP -0.236572190147455 2.76738607194933e-05 NA NA NA hsa-miR-301a-3p IL6R 2.14132004241926 4.46255413526808e-25 -0.0486500175487801 0.809389037083792 mirMAP -0.179160081092364 8.05822285018416e-06 NA NA NA hsa-miR-30a-5p IL6R -1.79779915425811 1.93360169837799e-26 -0.0486500175487801 0.809389037083792 mirMAP -0.240383543244608 9.339773290795e-07 NA NA NA hsa-miR-30b-5p IL6R -0.400238605368173 0.00346540992719245 -0.0486500175487801 0.809389037083792 mirMAP -0.389384992570436 7.44134431805409e-10 NA NA NA hsa-miR-30c-5p IL6R 0.021222006155897 0.886366656528128 -0.0486500175487801 0.809389037083792 mirMAP -0.413354869962516 1.1682658103537e-12 NA NA NA hsa-miR-320a IL6R 0.801356001806321 4.91397101474502e-09 -0.0486500175487801 0.809389037083792 miRanda;miRNATAP -0.362518536672091 6.91550938771451e-09 NA NA NA hsa-miR-34a-5p IL6R -0.117372471043915 0.364001947180738 -0.0486500175487801 0.809389037083792 MirTarget -0.630509408577177 6.97948912426972e-22 NA NA NA hsa-miR-361-3p IL6R 0.272298288982435 0.0147874880476998 -0.0486500175487801 0.809389037083792 MirTarget -0.389865552116126 6.55313745503612e-07 NA NA NA hsa-miR-454-3p IL6R 1.54137391927201 4.15861570449376e-20 -0.0486500175487801 0.809389037083792 mirMAP -0.336428933853486 1.05104072133221e-11 NA NA NA hsa-miR-501-5p IL6R 1.02806906860218 1.63456814370548e-09 -0.0486500175487801 0.809389037083792 miRNATAP -0.213835594012355 2.94955017701203e-05 NA NA NA hsa-miR-576-5p IL6R 0.940432050128373 6.90227595663302e-12 -0.0486500175487801 0.809389037083792 mirMAP -0.267701577746119 1.89976637762979e-05 NA NA NA hsa-miR-590-5p IL6R 0.763025362395968 3.65305892505623e-09 -0.0486500175487801 0.809389037083792 MirTarget;miRNATAP -0.238788817871458 0.000363136188095853 NA NA NA hsa-miR-93-5p IL6R 1.61042951896619 5.1280369606967e-24 -0.0486500175487801 0.809389037083792 mirMAP -0.320039043904434 7.06946338442526e-10 NA NA NA hsa-miR-129-5p IL7 -0.246329588499478 0.436451191224681 -0.629592654937052 0.00492986022645087 miRanda -0.10970529345841 0.000457314825869968 NA NA NA hsa-miR-335-3p IL7 0.336785882180547 0.0542446207938138 -0.629592654937052 0.00492986022645087 mirMAP -0.206361525279965 0.000216397820750568 NA NA NA hsa-miR-429 IL7 0.559451508722375 0.00563641638673083 -0.629592654937052 0.00492986022645087 miRanda -0.155273544396255 0.0012851075934239 NA NA NA hsa-miR-542-3p IL7 0.643308814904977 8.81635403230104e-07 -0.629592654937052 0.00492986022645087 miRanda -0.326534071162481 9.95714087036144e-06 NA NA NA hsa-miR-944 IL7 1.47323925060177 2.61626403984929e-13 -0.629592654937052 0.00492986022645087 mirMAP -0.200670712484546 2.10309547998525e-05 NA NA NA hsa-miR-125a-5p IL7R 0.215366061934933 0.119550904549401 0.946577743770938 0.00163962349331115 miRanda -0.369240270457518 0.000102693857245887 NA NA NA hsa-miR-199b-5p IL7R -1.08432682485992 7.68241801134089e-10 0.946577743770938 0.00163962349331115 miRanda -0.248813946329483 0.000687924969149623 NA NA NA hsa-miR-26b-5p IL7R -0.254478038884324 0.0285227763044636 0.946577743770938 0.00163962349331115 miRNAWalker2_validate -0.557748325284492 7.76166793562327e-07 NA NA NA hsa-miR-335-3p IL7R 0.336785882180547 0.0542446207938138 0.946577743770938 0.00163962349331115 mirMAP -0.254649741413612 0.000692573966156646 NA NA NA hsa-miR-501-5p IL7R 1.02806906860218 1.63456814370548e-09 0.946577743770938 0.00163962349331115 mirMAP -0.31997471243968 3.01541280296403e-05 NA NA NA hsa-miR-508-3p IL7R -1.16967833934103 0.00223596380485201 0.946577743770938 0.00163962349331115 mirMAP -0.122345045728517 0.00039549353993727 NA NA NA hsa-miR-576-5p IL7R 0.940432050128373 6.90227595663302e-12 0.946577743770938 0.00163962349331115 mirMAP -0.27454676626619 0.00357071376155502 NA NA NA hsa-let-7a-3p INSR 0.0966652362351867 0.423761916840503 -0.194107437746236 0.136686106038653 mirMAP -0.213874804767624 5.33683701331108e-06 NA NA NA hsa-miR-103a-2-5p INSR 1.37988337975616 6.74852943995612e-08 -0.194107437746236 0.136686106038653 mirMAP -0.185176304169939 1.72917381583809e-15 NA NA NA hsa-miR-141-3p INSR 0.730011517758706 0.000120338355004032 -0.194107437746236 0.136686106038653 mirMAP -0.164089082653693 2.41794279301179e-08 27186273 microRNA 141 inhibits thyroid cancer cell growth and metastasis by targeting insulin receptor substrate 2 metastasis thyroid cancer hsa-miR-15a-5p INSR 0.783550182002274 2.60699595655907e-11 -0.194107437746236 0.136686106038653 miRNATAP -0.330613162911114 1.4258873973789e-12 NA NA NA hsa-miR-15b-3p INSR 1.05020782493504 6.38723677324836e-14 -0.194107437746236 0.136686106038653 mirMAP -0.110818903933092 0.00519177233341178 NA NA NA hsa-miR-181b-5p INSR 0.974255518824355 2.64876280203475e-16 -0.194107437746236 0.136686106038653 mirMAP -0.161793140106989 0.000494697978258431 NA NA NA hsa-miR-205-5p INSR 1.50759485376634 2.0003886738248e-16 -0.194107437746236 0.136686106038653 mirMAP -0.249199158776933 1.17022684270028e-17 NA NA NA hsa-miR-21-5p INSR 1.62465922021121 3.44191300985109e-58 -0.194107437746236 0.136686106038653 mirMAP -0.203247220767756 5.06929122356756e-05 24804226;27220494;21618027 Downregulation of miR-21 in radioresistant NSCLC A549 cells inhibited the colony-forming ability and proliferation of A549 cells after IR; Moreover silencing miR-21 enhanced apoptosis of A549 cells induced by IR accompanied by decreased phosphorylated-Akt protein level; However PI3K activator IGF-1 reversed suppression of phosphorylated-Akt protein level and promotion of apoptosis of A549 cells after IR caused by miR-21 knockdown; Silencing miR-21 in radioresistant NSCLC A549 cells sensitized them to IR by inhibiting cell proliferation and enhancing cell apoptosis through inhibition of PI3K/Akt signaling pathway;In addition we also demonstrated that miR-21 confers decreased autophagy in cervical cancer cells after IR via the Akt-mTOR signaling pathway;In this study we found that miR-21 expression was upregulated in response to ionizing radiation IR in U251 cells which suggested that miR-21 could be involved in the response of U251 cells to radiation; We showed that a miR-21 inhibitor enhanced IR-induced glioblastoma cell growth arrest and increased the level of apoptosis which was probably caused by abrogation of the G2-M arrest induced by IR ;;drug resistance lung squamous cell cancer;cervical and endocervical cancer;glioblastoma hsa-miR-27a-3p INSR 0.348456440505425 0.00126682892514312 -0.194107437746236 0.136686106038653 miRNATAP -0.164835039787237 0.00175308822183204 NA NA NA hsa-miR-342-3p INSR 0.99756868977753 9.28499866272332e-10 -0.194107437746236 0.136686106038653 miRanda -0.185126993913913 4.99791756945346e-08 NA NA NA hsa-miR-424-5p INSR 1.48125289532143 9.10372985713165e-19 -0.194107437746236 0.136686106038653 miRNATAP -0.103497110418724 0.00156134280325816 NA NA NA hsa-miR-590-3p INSR 0.221436901462551 0.0965904764063157 -0.194107437746236 0.136686106038653 PITA;miRanda;mirMAP;miRNATAP -0.14436872279385 0.000720483868151073 NA NA NA hsa-miR-590-5p INSR 0.763025362395968 3.65305892505623e-09 -0.194107437746236 0.136686106038653 mirMAP -0.223670217758919 1.99577474916714e-07 NA NA NA hsa-miR-7-1-3p INSR 1.13646121619622 1.49823237535933e-14 -0.194107437746236 0.136686106038653 mirMAP -0.181175997957957 1.11474960466591e-06 NA NA NA hsa-miR-126-3p IRS1 0.0487843863772834 0.730130847436008 0.368700428225394 0.0670438573223234 miRNAWalker2_validate;miRTarBase;miRNATAP -0.191131636733423 0.00214861018537744 24312276;23981989;26893720 Down regulation of miR 126 is associated with colorectal cancer cells proliferation migration and invasion by targeting IRS 1 via the AKT and ERK1/2 signaling pathways; In this study we identified the potential effects of miR-126 on some important biological properties of CRC cells and clarified the regulation of insulin receptor substrate 1 IRS-1 and its possible signaling pathway by miR-126; The 3'-untranslated region 3'-UTR of IRS-1 regulated by miR-126 was analyzed by using a dual-luciferase reporter assay; We found that IRS-1 is the functional downstream target of miR-126 by directly targeting the 3'-UTR of IRS-1; Endogenous miR-126 and exogenous miR-126 mimic inhibited IRS-1 expression; Furthermore gain-of-function or loss-of-function studies showed that over-expression of miR-126 down-regulated IRS-1 suppressed AKT and ERK1/2 activation CRC cells proliferation migration invasion and caused cell cycle arrest but had no effect on cell apoptosis; Knockdown of miR-126 promoted these processes in HCT-116 cells and promoted AKT and ERK1/2 activation by up-regulating the expression of the IRS-1 protein; MiR-126 may play roles in regulation of the biological behavior of CRC cells at least in part by targeting IRS-1 via AKT and ERK1/2 signaling pathways;It has been shown that IRS1 SLC75A and TOM1 were the potential target genes of miR-126 in colon cancer;Molecular mechanism investigation established that insulin receptor substrate 1 IRS1 functioned as a direct miR-126 target and its expression was negatively regulated by miR-126 at a post-transcriptional level in the SKOV3 cells; Additionally the overexpression of IRS1 reversed the inhibitory effect of miR-126 overexpression on SKOV3 cell migration and invasion; In conclusion the current study demonstrated that miR-126 inhibited EC cell migration and invasion at least partially through the direct targeting of IRS1 suggesting that miR-126 may aid the treatment of EC metastasis ;;cell migration;metastasis colorectal cancer;colon cancer;endometrial cancer hsa-miR-142-5p IRS1 0.288897753038094 0.0900009317815725 0.368700428225394 0.0670438573223234 MirTarget;PITA -0.162025091533251 0.0016564617970589 NA NA NA hsa-miR-148a-3p IRS1 -0.428944290834563 0.00954246923521465 0.368700428225394 0.0670438573223234 miRNAWalker2_validate;miRTarBase -0.353601277678189 1.09149680278196e-11 NA NA NA hsa-miR-16-1-3p IRS1 0.955017760172879 5.95379292601146e-11 0.368700428225394 0.0670438573223234 MirTarget -0.343013449931184 4.65609541925474e-09 NA NA NA hsa-miR-17-3p IRS1 -0.0127974722290336 0.909559935689875 0.368700428225394 0.0670438573223234 MirTarget -0.210586743641699 0.0073520244664663 NA NA NA hsa-miR-200b-3p IRS1 0.0717138787925347 0.682858087587209 0.368700428225394 0.0670438573223234 TargetScan -0.328876371023069 2.39302426876653e-11 26314828 Taken together our results suggest that miR-200 may activate AKT in lung adenocarcinoma cells through a FOG2-independent mechanism involving IRS-1 lung cancer hsa-miR-200c-3p IRS1 0.630251054099546 0.000131975031451555 0.368700428225394 0.0670438573223234 miRNATAP -0.219124428743904 3.28651492645702e-05 NA NA NA hsa-miR-27b-3p IRS1 -0.732682718863563 2.26896143573324e-09 0.368700428225394 0.0670438573223234 MirTarget;miRNATAP -0.37553742543542 8.62033668289833e-08 NA NA NA hsa-miR-30a-5p IRS1 -1.79779915425811 1.93360169837799e-26 0.368700428225394 0.0670438573223234 MirTarget;miRNATAP -0.185934232685065 0.000158575656242886 NA NA NA hsa-miR-30b-5p IRS1 -0.400238605368173 0.00346540992719245 0.368700428225394 0.0670438573223234 MirTarget -0.442575958175948 1.95567373162078e-12 NA NA NA hsa-miR-30c-5p IRS1 0.021222006155897 0.886366656528128 0.368700428225394 0.0670438573223234 MirTarget;miRNATAP -0.36533788069298 4.08454834477465e-10 NA NA NA hsa-miR-30d-5p IRS1 -0.38399848121878 0.000171129616944749 0.368700428225394 0.0670438573223234 MirTarget;miRNATAP -0.454426606410707 1.0175433558208e-07 NA NA NA hsa-miR-30e-5p IRS1 -1.02114836019762 6.81961221797866e-17 0.368700428225394 0.0670438573223234 MirTarget -0.51625461963964 3.9456214828828e-14 NA NA NA hsa-miR-335-3p IRS1 0.336785882180547 0.0542446207938138 0.368700428225394 0.0670438573223234 MirTarget -0.283095257336078 1.13998983094014e-08 NA NA NA hsa-miR-33a-5p IRS1 1.12988965056352 3.35742517382153e-07 0.368700428225394 0.0670438573223234 MirTarget -0.227903611854945 3.77495546767899e-09 NA NA NA hsa-miR-33b-5p IRS1 0.681845193600723 0.00407790722487864 0.368700428225394 0.0670438573223234 MirTarget -0.211666214886333 1.72554364723835e-08 NA NA NA hsa-miR-429 IRS1 0.559451508722375 0.00563641638673083 0.368700428225394 0.0670438573223234 miRanda;miRNATAP -0.251038467654472 4.37198601687589e-09 NA NA NA hsa-miR-590-3p IRS1 0.221436901462551 0.0965904764063157 0.368700428225394 0.0670438573223234 PITA;miRanda;miRNATAP -0.295708733720115 6.81670543594644e-06 NA NA NA hsa-miR-628-5p IRS1 -0.554239048796013 4.92386883216087e-05 0.368700428225394 0.0670438573223234 miRNATAP -0.269061331450409 2.45832830205658e-05 NA NA NA hsa-miR-660-5p IRS1 -0.202705992887645 0.101093376073573 0.368700428225394 0.0670438573223234 MirTarget;miRNATAP -0.468299253304393 2.40522902870603e-11 NA NA NA hsa-miR-96-5p IRS1 1.42326703011157 4.39736150032373e-14 0.368700428225394 0.0670438573223234 MirTarget;TargetScan;miRNATAP -0.239555892208113 9.77971075435514e-08 21993544 hsa miR 96 up regulates MAP4K1 and IRS1 and may function as a promising diagnostic marker in human bladder urothelial carcinomas; Altogether these results suggest that hsa-miR-96 may affect the growth of bladder cancer cells by up-regulating IRS1 and MAP4K1 levels functioning as a promising diagnostic marker in human bladder urothelial carcinomas bladder cancer hsa-miR-126-5p ITGA1 -0.953529188793816 7.91719143295591e-16 1.67341801792518 4.50395973838986e-18 mirMAP -0.232491607374117 0.00119310918873316 NA NA NA hsa-miR-141-5p ITGA1 0.623874471326586 0.0018690552472983 1.67341801792518 4.50395973838986e-18 MirTarget -0.213103535798224 6.85812629505796e-07 NA NA NA hsa-miR-193a-3p ITGA1 0.22120710726779 0.111827069464729 1.67341801792518 4.50395973838986e-18 miRanda -0.202685010647772 0.0012331347597835 NA NA NA hsa-miR-200a-5p ITGA1 0.701063526850019 0.000188402923774663 1.67341801792518 4.50395973838986e-18 mirMAP -0.319342249679662 1.67403159333903e-12 NA NA NA hsa-miR-200b-3p ITGA1 0.0717138787925347 0.682858087587209 1.67341801792518 4.50395973838986e-18 MirTarget -0.409214755957358 2.15156747518831e-17 NA NA NA hsa-miR-200b-5p ITGA1 0.02621402664548 0.883725338810228 1.67341801792518 4.50395973838986e-18 mirMAP -0.325178240994021 1.02120967262767e-11 NA NA NA hsa-miR-200c-3p ITGA1 0.630251054099546 0.000131975031451555 1.67341801792518 4.50395973838986e-18 MirTarget -0.235631195040831 6.57308022952092e-06 NA NA NA hsa-miR-30d-3p ITGA1 -0.577371911152798 2.02950840095287e-06 1.67341801792518 4.50395973838986e-18 MirTarget -0.435823608646342 6.23912586959594e-10 NA NA NA hsa-miR-30e-3p ITGA1 -0.890635378639789 1.65740480611339e-16 1.67341801792518 4.50395973838986e-18 MirTarget -0.274296626376993 0.000481424189481653 NA NA NA hsa-miR-335-5p ITGA1 -1.17227779671552 1.49282618530733e-10 1.67341801792518 4.50395973838986e-18 miRNAWalker2_validate -0.155344655266421 0.00087537570987604 NA NA NA hsa-miR-3607-3p ITGA1 1.01377165357363 9.13355519701165e-05 1.67341801792518 4.50395973838986e-18 MirTarget -0.139476952962332 2.71438663907362e-05 NA NA NA hsa-miR-362-3p ITGA1 -0.697212068252854 2.61718493418184e-06 1.67341801792518 4.50395973838986e-18 miRanda -0.289337760307752 6.25124928994218e-07 NA NA NA hsa-miR-374a-5p ITGA1 -0.621903385111545 6.61791773205282e-12 1.67341801792518 4.50395973838986e-18 mirMAP -0.3735105009491 8.32372863950503e-05 NA NA NA hsa-miR-374b-5p ITGA1 -0.288413933608091 0.0041474558664058 1.67341801792518 4.50395973838986e-18 mirMAP -0.389722968000046 6.83846638352546e-06 NA NA NA hsa-miR-429 ITGA1 0.559451508722375 0.00563641638673083 1.67341801792518 4.50395973838986e-18 MirTarget;miRanda -0.324105960350094 1.08399585463219e-14 NA NA NA hsa-miR-576-5p ITGA1 0.940432050128373 6.90227595663302e-12 1.67341801792518 4.50395973838986e-18 mirMAP -0.184773820350032 0.00305652032254665 NA NA NA hsa-miR-590-5p ITGA1 0.763025362395968 3.65305892505623e-09 1.67341801792518 4.50395973838986e-18 miRanda;mirMAP -0.333054163828861 4.56568459437063e-07 NA NA NA hsa-miR-664a-3p ITGA1 -0.256108763664991 0.0513188660751664 1.67341801792518 4.50395973838986e-18 mirMAP -0.348512561924805 1.21481274336114e-07 NA NA NA hsa-miR-7-1-3p ITGA1 1.13646121619622 1.49823237535933e-14 1.67341801792518 4.50395973838986e-18 mirMAP -0.175490988146662 0.00225567042174286 NA NA NA hsa-let-7g-3p ITGA10 0.637019243992294 0.000204623048574065 -0.616576333493808 0.00117238859781515 MirTarget;miRNATAP -0.133547059423523 0.00562857771117045 NA NA NA hsa-miR-107 ITGA10 -0.0447040564279497 0.671618791096755 -0.616576333493808 0.00117238859781515 miRanda -0.244186500494741 0.00212750947071973 NA NA NA hsa-miR-15a-5p ITGA10 0.783550182002274 2.60699595655907e-11 -0.616576333493808 0.00117238859781515 MirTarget -0.197792265059081 0.00455247556374605 NA NA NA hsa-miR-15b-5p ITGA10 0.85315666454713 3.79816274836297e-12 -0.616576333493808 0.00117238859781515 MirTarget -0.395911066399416 1.61386272794139e-09 NA NA NA hsa-miR-16-5p ITGA10 0.521122945828175 1.40561786410572e-06 -0.616576333493808 0.00117238859781515 MirTarget -0.414761526171696 4.74827365376574e-08 NA NA NA hsa-miR-320b ITGA10 1.23473838180754 3.04337566045537e-14 -0.616576333493808 0.00117238859781515 miRanda -0.186113923975699 0.000182576968534464 NA NA NA hsa-miR-324-5p ITGA10 1.66709479707179 1.45961450445769e-23 -0.616576333493808 0.00117238859781515 miRanda;miRNATAP -0.182502533171657 0.000123476810915701 NA NA NA hsa-miR-424-5p ITGA10 1.48125289532143 9.10372985713165e-19 -0.616576333493808 0.00117238859781515 MirTarget -0.143356252911365 0.00277429593872826 NA NA NA hsa-miR-429 ITGA10 0.559451508722375 0.00563641638673083 -0.616576333493808 0.00117238859781515 miRanda;miRNATAP -0.250180968335665 6.03889317188334e-10 NA NA NA hsa-miR-484 ITGA10 0.918280909791707 1.39168306854263e-14 -0.616576333493808 0.00117238859781515 miRNATAP -0.217561886451906 0.00140137021544575 NA NA NA hsa-miR-940 ITGA10 1.25303020594374 1.3005368359451e-10 -0.616576333493808 0.00117238859781515 MirTarget;miRNATAP -0.201632646107501 1.64845056821795e-06 NA NA NA hsa-miR-29a-3p ITGA11 -1.26881270980079 2.82496991513463e-22 2.27955019437841 3.30117816539988e-13 miRNAWalker2_validate;miRTarBase -0.566512227095331 2.54252574944714e-08 NA NA NA hsa-miR-429 ITGA11 0.559451508722375 0.00563641638673083 2.27955019437841 3.30117816539988e-13 miRNATAP -0.45535251176264 1.83535410012877e-11 NA NA NA hsa-miR-532-5p ITGA11 -0.021857649390892 0.830992272120134 2.27955019437841 3.30117816539988e-13 miRNATAP -0.430832923369029 0.001765380731441 NA NA NA hsa-miR-103a-3p ITGA2 0.556219385347418 1.55815736455067e-09 0.346311971701161 0.0557914662203759 miRNAWalker2_validate;MirTarget;miRNATAP -0.263221912739454 0.0020146102943405 NA NA NA hsa-miR-130a-3p ITGA2 0.67051191119964 4.89747518735144e-06 0.346311971701161 0.0557914662203759 mirMAP -0.167229255007144 0.00174241573906955 NA NA NA hsa-miR-139-5p ITGA2 -1.46099200329485 7.85040381494472e-22 0.346311971701161 0.0557914662203759 PITA;miRanda -0.179977342422204 0.00029435564534397 NA NA NA hsa-miR-15a-5p ITGA2 0.783550182002274 2.60699595655907e-11 0.346311971701161 0.0557914662203759 MirTarget;miRNATAP -0.295271652959175 7.30567926728194e-06 NA NA NA hsa-miR-186-5p ITGA2 0.353452958261612 0.000145058448579496 0.346311971701161 0.0557914662203759 mirMAP -0.366781194007422 1.56320367087872e-05 NA NA NA hsa-miR-18a-5p ITGA2 1.65455873230328 3.76457892277775e-20 0.346311971701161 0.0557914662203759 MirTarget -0.155120230894284 0.000230282139110839 NA NA NA hsa-miR-199a-5p ITGA2 -0.364835768178638 0.0435119211101981 0.346311971701161 0.0557914662203759 miRanda -0.138525415191616 0.00149655053123041 NA NA NA hsa-miR-199b-5p ITGA2 -1.08432682485992 7.68241801134089e-10 0.346311971701161 0.0557914662203759 miRanda -0.125699731513756 0.00433622030989088 NA NA NA hsa-miR-19a-3p ITGA2 1.35800152353624 2.80940447111944e-12 0.346311971701161 0.0557914662203759 MirTarget -0.224082677864399 1.15550463555285e-08 NA NA NA hsa-miR-19b-3p ITGA2 0.538732279378089 0.000622008277870679 0.346311971701161 0.0557914662203759 MirTarget -0.316307052598501 1.30777814836052e-10 NA NA NA hsa-miR-26b-5p ITGA2 -0.254478038884324 0.0285227763044636 0.346311971701161 0.0557914662203759 mirMAP -0.265344476520545 9.63042196397978e-05 NA NA NA hsa-miR-301a-3p ITGA2 2.14132004241926 4.46255413526808e-25 0.346311971701161 0.0557914662203759 mirMAP -0.12632763206279 0.000487530065268887 NA NA NA hsa-miR-30a-5p ITGA2 -1.79779915425811 1.93360169837799e-26 0.346311971701161 0.0557914662203759 miRNAWalker2_validate;mirMAP -0.126199425147886 0.00447937148121829 NA NA NA hsa-miR-30b-5p ITGA2 -0.400238605368173 0.00346540992719245 0.346311971701161 0.0557914662203759 mirMAP -0.219969877332466 0.000130518036619771 NA NA NA hsa-miR-30c-5p ITGA2 0.021222006155897 0.886366656528128 0.346311971701161 0.0557914662203759 mirMAP -0.332986480926492 2.32422656718908e-10 NA NA NA hsa-miR-324-5p ITGA2 1.66709479707179 1.45961450445769e-23 0.346311971701161 0.0557914662203759 miRanda -0.142938749031708 0.00158671999795899 NA NA NA hsa-miR-374b-5p ITGA2 -0.288413933608091 0.0041474558664058 0.346311971701161 0.0557914662203759 MirTarget -0.297780075060814 0.000155810387599993 NA NA NA hsa-miR-454-3p ITGA2 1.54137391927201 4.15861570449376e-20 0.346311971701161 0.0557914662203759 mirMAP -0.191757239033812 2.10849293345859e-05 NA NA NA hsa-miR-495-3p ITGA2 -1.47803501311999 6.88839745293927e-13 0.346311971701161 0.0557914662203759 mirMAP -0.120499026146334 0.00132477071990231 NA NA NA hsa-miR-532-5p ITGA2 -0.021857649390892 0.830992272120134 0.346311971701161 0.0557914662203759 MirTarget -0.286013181143453 0.000230449758178618 NA NA NA hsa-miR-590-5p ITGA2 0.763025362395968 3.65305892505623e-09 0.346311971701161 0.0557914662203759 miRanda -0.16147059329483 0.00748626516135886 NA NA NA hsa-miR-664a-3p ITGA2 -0.256108763664991 0.0513188660751664 0.346311971701161 0.0557914662203759 MirTarget;mirMAP -0.3135544144911 1.51188551081592e-07 NA NA NA hsa-miR-129-5p ITGA3 -0.246329588499478 0.436451191224681 1.42521574039313 1.3762201197134e-11 MirTarget -0.133334049296482 8.17819400855713e-06 NA NA NA hsa-miR-181c-5p ITGA3 -0.168991199007857 0.196949106150297 1.42521574039313 1.3762201197134e-11 miRNATAP -0.505417536328942 7.33010514657585e-13 NA NA NA hsa-miR-199a-5p ITGA3 -0.364835768178638 0.0435119211101981 1.42521574039313 1.3762201197134e-11 MirTarget;PITA;miRanda;miRNATAP -0.202715698601488 8.8151098322191e-05 NA NA NA hsa-miR-199b-5p ITGA3 -1.08432682485992 7.68241801134089e-10 1.42521574039313 1.3762201197134e-11 MirTarget;PITA;miRanda;miRNATAP -0.240706213072019 3.70903821296021e-06 NA NA NA hsa-miR-28-5p ITGA3 -0.026996999089909 0.733047113251652 1.42521574039313 1.3762201197134e-11 miRanda -0.786041964807899 3.49902711558731e-11 NA NA NA hsa-miR-296-5p ITGA3 -0.425442682383961 0.0948240114267711 1.42521574039313 1.3762201197134e-11 MirTarget -0.149220507438288 6.98622347332687e-05 NA NA NA hsa-miR-139-5p ITGA4 -1.46099200329485 7.85040381494472e-22 0.708436253735582 0.00117066563281147 miRanda -0.158121609772204 0.0087563678277089 NA NA NA hsa-miR-17-5p ITGA4 1.41924888736771 2.75805544953758e-18 0.708436253735582 0.00117066563281147 TargetScan -0.390972895875394 2.13265911736241e-12 NA NA NA hsa-miR-30c-5p ITGA4 0.021222006155897 0.886366656528128 0.708436253735582 0.00117066563281147 miRNAWalker2_validate -0.417142987499932 4.92681506128234e-11 NA NA NA hsa-miR-339-5p ITGA4 1.07771430326938 2.45772601859307e-09 0.708436253735582 0.00117066563281147 miRanda -0.291101152542942 1.53992182812124e-08 NA NA NA hsa-miR-455-5p ITGA4 1.408595672323 5.52039116456697e-22 0.708436253735582 0.00117066563281147 miRanda -0.196576036030685 0.00172239672065622 NA NA NA hsa-miR-148a-3p ITGA5 -0.428944290834563 0.00954246923521465 2.26391898266591 1.00857076132898e-26 miRNATAP -0.460739953170076 7.20573535736267e-16 NA NA NA hsa-miR-25-3p ITGA5 0.76549796417801 3.32282098247097e-11 2.26391898266591 1.00857076132898e-26 miRNATAP -0.311424655866672 0.000169315670080004 NA NA NA hsa-miR-26a-5p ITGA5 -1.09269574587169 1.24020612216319e-22 2.26391898266591 1.00857076132898e-26 miRNATAP -0.544702822636276 3.95778079261406e-11 25537511 Furthermore we provide experimental evidence to confirm that ITGA5 is a bona fide target of miR-26a liver cancer hsa-miR-26b-5p ITGA5 -0.254478038884324 0.0285227763044636 2.26391898266591 1.00857076132898e-26 miRNATAP -0.460487885590726 3.06199193929785e-08 NA NA NA hsa-miR-27b-3p ITGA5 -0.732682718863563 2.26896143573324e-09 2.26391898266591 1.00857076132898e-26 miRNATAP -0.702938145205959 1.39500552222077e-20 NA NA NA hsa-miR-3065-3p ITGA5 -0.543069092777161 0.0213164885178151 2.26391898266591 1.00857076132898e-26 miRNATAP -0.197509312452116 1.29049230874317e-06 NA NA NA hsa-miR-30a-5p ITGA5 -1.79779915425811 1.93360169837799e-26 2.26391898266591 1.00857076132898e-26 miRNATAP -0.353113981398324 5.08086526872968e-11 NA NA NA hsa-miR-30c-5p ITGA5 0.021222006155897 0.886366656528128 2.26391898266591 1.00857076132898e-26 miRNATAP -0.360580446789248 2.85115027057481e-08 NA NA NA hsa-miR-30d-5p ITGA5 -0.38399848121878 0.000171129616944749 2.26391898266591 1.00857076132898e-26 miRNATAP -0.786437445032788 1.97955295381766e-17 NA NA NA hsa-miR-32-5p ITGA5 -0.317310201890053 0.0102525324475293 2.26391898266591 1.00857076132898e-26 miRNATAP -0.467609983986132 1.86514636190523e-09 NA NA NA hsa-miR-338-3p ITGA5 -0.948755228846395 8.99167125682392e-08 2.26391898266591 1.00857076132898e-26 miRanda -0.178057647560196 0.000985832440085101 NA NA NA hsa-miR-429 ITGA5 0.559451508722375 0.00563641638673083 2.26391898266591 1.00857076132898e-26 miRNATAP -0.323621086900322 6.17229059702819e-12 NA NA NA hsa-miR-92a-3p ITGA5 0.994679542307232 1.32587679156217e-16 2.26391898266591 1.00857076132898e-26 miRNAWalker2_validate;miRTarBase;miRNATAP -0.240966436799812 0.00219729113638704 23499550 The level of miR-92a expression was significantly inversely correlated with ITGA5 expression in various cancer cells; miR-92a overexpression reduced the luciferase activity of the ITGA5 3'-untranslated region suggesting that ITGA5 mRNA is a direct target of miR-92a ovarian cancer hsa-miR-125b-2-3p ITGA6 -1.87765459914049 1.24704155651697e-13 1.64611930993808 4.50484535118728e-16 mirMAP -0.255382848482671 8.29268917678958e-14 NA NA NA hsa-miR-217 ITGA6 -1.35391381055929 2.42394951427902e-09 1.64611930993808 4.50484535118728e-16 miRanda -0.203968291402068 1.79650320738051e-07 NA NA NA hsa-miR-30a-5p ITGA6 -1.79779915425811 1.93360169837799e-26 1.64611930993808 4.50484535118728e-16 miRNAWalker2_validate -0.396304205077658 1.89908587847505e-15 NA NA NA hsa-miR-32-5p ITGA6 -0.317310201890053 0.0102525324475293 1.64611930993808 4.50484535118728e-16 miRNAWalker2_validate -0.263016113744254 0.000357219730173333 NA NA NA hsa-miR-335-3p ITGA6 0.336785882180547 0.0542446207938138 1.64611930993808 4.50484535118728e-16 mirMAP -0.190433704095508 0.00024208062197396 NA NA NA hsa-miR-342-3p ITGA6 0.99756868977753 9.28499866272332e-10 1.64611930993808 4.50484535118728e-16 miRanda -0.150922457530857 0.00607415898846759 NA NA NA hsa-miR-34a-5p ITGA6 -0.117372471043915 0.364001947180738 1.64611930993808 4.50484535118728e-16 miRNAWalker2_validate -0.605590436287524 8.6879407505893e-19 NA NA NA hsa-miR-330-5p ITGA7 0.944693925383906 5.04972895657346e-13 -0.891039510966107 0.000540872218469012 miRanda -0.267233423437299 0.00156205590487152 NA NA NA hsa-miR-339-5p ITGA7 1.07771430326938 2.45772601859307e-09 -0.891039510966107 0.000540872218469012 miRanda -0.220921963567891 0.0003154321997699 NA NA NA hsa-miR-34c-3p ITGA7 0.637366654488255 0.0071580891372093 -0.891039510966107 0.000540872218469012 miRNATAP -0.136983887300611 0.00386786310208693 NA NA NA hsa-miR-130a-3p ITGA8 0.67051191119964 4.89747518735144e-06 -0.746675246206148 0.0153267795836345 mirMAP -0.891936958959985 1.16316666012532e-24 NA NA NA hsa-miR-130b-3p ITGA8 1.44628430084411 9.13980959861273e-24 -0.746675246206148 0.0153267795836345 mirMAP -0.2473534831751 0.00570185251573659 NA NA NA hsa-miR-16-1-3p ITGA8 0.955017760172879 5.95379292601146e-11 -0.746675246206148 0.0153267795836345 mirMAP -0.629999196017991 1.48479230636902e-12 NA NA NA hsa-miR-183-5p ITGA8 1.4313129319945 6.25230916431996e-14 -0.746675246206148 0.0153267795836345 miRNAWalker2_validate -0.288682557922511 2.44422164750369e-05 NA NA NA hsa-miR-19b-1-5p ITGA8 0.757034032029085 2.99828133413343e-07 -0.746675246206148 0.0153267795836345 mirMAP -0.715618778930715 3.48071121695928e-16 NA NA NA hsa-miR-205-3p ITGA8 1.2960640797621 5.80786479909147e-11 -0.746675246206148 0.0153267795836345 mirMAP -0.484316556088504 1.07889529066419e-13 NA NA NA hsa-miR-21-5p ITGA8 1.62465922021121 3.44191300985109e-58 -0.746675246206148 0.0153267795836345 mirMAP -0.612103563112586 2.24327077404048e-07 NA NA NA hsa-miR-301a-3p ITGA8 2.14132004241926 4.46255413526808e-25 -0.746675246206148 0.0153267795836345 mirMAP -0.521301470283365 3.16600301470295e-18 NA NA NA hsa-miR-30b-5p ITGA8 -0.400238605368173 0.00346540992719245 -0.746675246206148 0.0153267795836345 mirMAP -0.611196843392497 2.71236042820306e-10 NA NA NA hsa-miR-30c-5p ITGA8 0.021222006155897 0.886366656528128 -0.746675246206148 0.0153267795836345 mirMAP -0.633859906700725 1.10219654385172e-12 NA NA NA hsa-miR-33a-5p ITGA8 1.12988965056352 3.35742517382153e-07 -0.746675246206148 0.0153267795836345 mirMAP -0.30486052080971 2.97595730791107e-07 NA NA NA hsa-miR-454-3p ITGA8 1.54137391927201 4.15861570449376e-20 -0.746675246206148 0.0153267795836345 mirMAP -0.735711249952109 2.52986240198362e-23 NA NA NA hsa-miR-590-5p ITGA8 0.763025362395968 3.65305892505623e-09 -0.746675246206148 0.0153267795836345 mirMAP -0.821731208881961 2.02158619602798e-16 NA NA NA hsa-miR-7-1-3p ITGA8 1.13646121619622 1.49823237535933e-14 -0.746675246206148 0.0153267795836345 mirMAP -0.492805042753509 1.98365293400317e-08 NA NA NA hsa-miR-944 ITGA8 1.47323925060177 2.61626403984929e-13 -0.746675246206148 0.0153267795836345 mirMAP -0.213541097882174 0.00103031475275809 NA NA NA hsa-miR-103a-2-5p ITGA9 1.37988337975616 6.74852943995612e-08 -1.02151955404317 7.40405441084336e-06 mirMAP -0.411532816827126 1.63875813029552e-24 NA NA NA hsa-miR-125a-5p ITGA9 0.215366061934933 0.119550904549401 -1.02151955404317 7.40405441084336e-06 MirTarget;PITA;miRanda -0.217454136284835 0.00275040745328883 NA NA NA hsa-miR-141-5p ITGA9 0.623874471326586 0.0018690552472983 -1.02151955404317 7.40405441084336e-06 MirTarget -0.229489651724265 3.4600311699056e-06 NA NA NA hsa-miR-200b-3p ITGA9 0.0717138787925347 0.682858087587209 -1.02151955404317 7.40405441084336e-06 mirMAP -0.363311575337102 1.07432004375791e-10 24518294;26334393 β1 integrin inhibition elicits a prometastatic switch through the TGFβ miR 200 ZEB network in E cadherin positive triple negative breast cancer;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ; breast cancer;esophageal cancer hsa-miR-205-3p ITGA9 1.2960640797621 5.80786479909147e-11 -1.02151955404317 7.40405441084336e-06 mirMAP -0.437849502554817 6.34372502736728e-20 NA NA NA hsa-miR-20a-3p ITGA9 1.34885093664027 2.07697464119202e-12 -1.02151955404317 7.40405441084336e-06 mirMAP -0.442815855290551 2.86026884094689e-19 NA NA NA hsa-miR-29a-5p ITGA9 0.323252792625584 0.0370417231222825 -1.02151955404317 7.40405441084336e-06 mirMAP -0.333305623261834 2.0058419375687e-07 26903137 We found that the up-regulation of hTERT in gastric cancer cells could inhibit the expression of miR-29a and enhance the expression of Integrin β1 ITGB1 gastric cancer hsa-miR-29b-1-5p ITGA9 1.39669186711325 4.36960953138935e-11 -1.02151955404317 7.40405441084336e-06 mirMAP -0.322061925725423 1.48953825281059e-12 NA NA NA hsa-miR-324-5p ITGA9 1.66709479707179 1.45961450445769e-23 -1.02151955404317 7.40405441084336e-06 miRanda -0.463793601080557 1.01339448411771e-16 NA NA NA hsa-miR-33a-3p ITGA9 0.20371038027126 0.212335697664505 -1.02151955404317 7.40405441084336e-06 mirMAP -0.222587693393635 0.00034687020499245 NA NA NA hsa-miR-33a-5p ITGA9 1.12988965056352 3.35742517382153e-07 -1.02151955404317 7.40405441084336e-06 mirMAP -0.364953497775282 4.08818749536791e-17 NA NA NA hsa-miR-33b-5p ITGA9 0.681845193600723 0.00407790722487864 -1.02151955404317 7.40405441084336e-06 mirMAP -0.184231274054894 1.94285021744494e-05 NA NA NA hsa-miR-429 ITGA9 0.559451508722375 0.00563641638673083 -1.02151955404317 7.40405441084336e-06 miRanda -0.409332685525983 1.36260216929988e-17 NA NA NA hsa-miR-452-3p ITGA9 1.09618110917892 2.21867884261816e-07 -1.02151955404317 7.40405441084336e-06 MirTarget -0.334042657395678 2.94457826406314e-13 NA NA NA hsa-miR-484 ITGA9 0.918280909791707 1.39168306854263e-14 -1.02151955404317 7.40405441084336e-06 miRNAWalker2_validate -0.339150502433451 3.40690170654556e-05 NA NA NA hsa-miR-501-5p ITGA9 1.02806906860218 1.63456814370548e-09 -1.02151955404317 7.40405441084336e-06 MirTarget -0.308513971045604 1.10479792709253e-07 NA NA NA hsa-miR-576-5p ITGA9 0.940432050128373 6.90227595663302e-12 -1.02151955404317 7.40405441084336e-06 mirMAP -0.52677510787811 5.98161710263162e-14 NA NA NA hsa-miR-589-3p ITGA9 1.59559692667315 6.2886410639161e-15 -1.02151955404317 7.40405441084336e-06 mirMAP -0.364577748649773 5.56257203431632e-14 NA NA NA hsa-miR-590-3p ITGA9 0.221436901462551 0.0965904764063157 -1.02151955404317 7.40405441084336e-06 miRanda -0.202580852354834 0.0072798938692014 NA NA NA hsa-miR-590-5p ITGA9 0.763025362395968 3.65305892505623e-09 -1.02151955404317 7.40405441084336e-06 miRanda -0.657489558151967 6.92514726534168e-19 NA NA NA hsa-miR-664a-3p ITGA9 -0.256108763664991 0.0513188660751664 -1.02151955404317 7.40405441084336e-06 MirTarget -0.200570552441418 0.00877673205950158 NA NA NA hsa-miR-877-5p ITGA9 1.97571572671705 2.0032239372269e-19 -1.02151955404317 7.40405441084336e-06 mirMAP -0.215549770824646 5.06357138528098e-06 NA NA NA hsa-miR-141-3p ITGAV 0.730011517758706 0.000120338355004032 0.843072722413884 7.35174048685618e-08 MirTarget -0.151504816364048 2.60191957759186e-05 NA NA NA hsa-miR-16-2-3p ITGAV 1.1567130855258 1.01867256952189e-14 0.843072722413884 7.35174048685618e-08 mirMAP -0.152931882097527 0.000678344169413549 NA NA NA hsa-miR-186-5p ITGAV 0.353452958261612 0.000145058448579496 0.843072722413884 7.35174048685618e-08 mirMAP -0.230636718119961 0.00200394016614757 NA NA NA hsa-miR-192-5p ITGAV 0.380924502586635 0.00986961967409205 0.843072722413884 7.35174048685618e-08 miRNAWalker2_validate;MirTarget -0.152317641817068 0.0011270082266526 NA NA NA hsa-miR-200a-3p ITGAV 0.607140814457753 0.00289840524858752 0.843072722413884 7.35174048685618e-08 MirTarget -0.174691571767693 1.79937598096872e-07 NA NA NA hsa-miR-25-3p ITGAV 0.76549796417801 3.32282098247097e-11 0.843072722413884 7.35174048685618e-08 MirTarget;miRNATAP -0.164460172212238 0.00535528447967496 NA NA NA hsa-miR-30e-3p ITGAV -0.890635378639789 1.65740480611339e-16 0.843072722413884 7.35174048685618e-08 mirMAP -0.211364972082851 0.000700463251854875 NA NA NA hsa-miR-32-5p ITGAV -0.317310201890053 0.0102525324475293 0.843072722413884 7.35174048685618e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.24892714346461 8.01816213102812e-06 NA NA NA hsa-miR-374a-5p ITGAV -0.621903385111545 6.61791773205282e-12 0.843072722413884 7.35174048685618e-08 mirMAP -0.259763716770641 0.000574661060601618 NA NA NA hsa-miR-374b-5p ITGAV -0.288413933608091 0.0041474558664058 0.843072722413884 7.35174048685618e-08 mirMAP -0.245676898462992 0.000368592536528629 NA NA NA hsa-miR-429 ITGAV 0.559451508722375 0.00563641638673083 0.843072722413884 7.35174048685618e-08 miRanda -0.159111405061634 2.6267798345519e-06 NA NA NA hsa-miR-576-5p ITGAV 0.940432050128373 6.90227595663302e-12 0.843072722413884 7.35174048685618e-08 PITA;mirMAP -0.142840628980598 0.00390783146519895 NA NA NA hsa-miR-582-3p ITGAV -0.248056267546012 0.143798829508405 0.843072722413884 7.35174048685618e-08 MirTarget -0.142674970515395 0.000453336261663201 NA NA NA hsa-miR-590-3p ITGAV 0.221436901462551 0.0965904764063157 0.843072722413884 7.35174048685618e-08 MirTarget;PITA;miRanda -0.154785375083429 0.00292484991114091 NA NA NA hsa-miR-7-1-3p ITGAV 1.13646121619622 1.49823237535933e-14 0.843072722413884 7.35174048685618e-08 mirMAP -0.189945721818657 2.8749953057338e-05 NA NA NA hsa-miR-92a-3p ITGAV 0.994679542307232 1.32587679156217e-16 0.843072722413884 7.35174048685618e-08 MirTarget;miRNATAP -0.186272222116105 0.000862110121080062 NA NA NA hsa-miR-140-3p ITGB1 -0.967453553824782 7.6999446305445e-23 0.635785538137535 3.67317452336206e-07 PITA -0.195418357895355 0.000288399163621207 NA NA NA hsa-miR-16-2-3p ITGB1 1.1567130855258 1.01867256952189e-14 0.635785538137535 3.67317452336206e-07 mirMAP -0.144153039723106 5.56490175975503e-05 NA NA NA hsa-miR-192-5p ITGB1 0.380924502586635 0.00986961967409205 0.635785538137535 3.67317452336206e-07 miRNAWalker2_validate -0.136984076544862 0.000231042554247732 NA NA NA hsa-miR-25-3p ITGB1 0.76549796417801 3.32282098247097e-11 0.635785538137535 3.67317452336206e-07 miRNAWalker2_validate -0.274217740525674 3.51439241030681e-09 NA NA NA hsa-miR-29b-3p ITGB1 -0.110721443686039 0.511264554091106 0.635785538137535 3.67317452336206e-07 MirTarget;miRNATAP -0.134604906339132 3.59761294597943e-05 NA NA NA hsa-miR-29c-3p ITGB1 -2.08166260448948 8.3238369390898e-24 0.635785538137535 3.67317452336206e-07 MirTarget;miRNATAP -0.184472776604945 1.06513669365178e-13 26766915 MiR 29c inhibits cell growth invasion and migration of pancreatic cancer by targeting ITGB1; Further analysis revealed that ITGB1 is one of the functional target genes of miR-29c and knockdown of ITGB1 inhibited the proliferation migration and invasion of PC cells which was similar to the effects of overexpression of miR-29c pancreatic cancer hsa-miR-429 ITGB1 0.559451508722375 0.00563641638673083 0.635785538137535 3.67317452336206e-07 miRanda -0.171979753608087 1.24153744115791e-10 NA NA NA hsa-miR-590-5p ITGB1 0.763025362395968 3.65305892505623e-09 0.635785538137535 3.67317452336206e-07 miRanda -0.110128606424978 0.0088994754623262 NA NA NA hsa-miR-7-1-3p ITGB1 1.13646121619622 1.49823237535933e-14 0.635785538137535 3.67317452336206e-07 MirTarget;mirMAP -0.130644713719968 0.000312721057462282 NA NA NA hsa-miR-769-5p ITGB1 0.0865819375213306 0.445395188017017 0.635785538137535 3.67317452336206e-07 miRNAWalker2_validate -0.162929805187605 0.000841672355138162 NA NA NA hsa-miR-186-5p ITGB3 0.353452958261612 0.000145058448579496 -0.160351074378419 0.548393025862139 mirMAP -0.409952109573956 0.00110247553027533 NA NA NA hsa-miR-18a-3p ITGB3 1.82583720936229 7.51297960972179e-19 -0.160351074378419 0.548393025862139 miRNATAP -0.259516675356121 3.08448216684668e-06 NA NA NA hsa-miR-221-3p ITGB3 0.410625614724387 0.000741090075261272 -0.160351074378419 0.548393025862139 MirTarget -0.282080665929398 0.00319271262689055 NA NA NA hsa-miR-222-3p ITGB3 1.08197052578759 2.32604040301699e-14 -0.160351074378419 0.548393025862139 MirTarget -0.473449166470346 2.16153769866078e-09 NA NA NA hsa-miR-30b-5p ITGB3 -0.400238605368173 0.00346540992719245 -0.160351074378419 0.548393025862139 mirMAP -0.439196050030113 1.85889909589552e-07 20498642 Enforced constitutive expression of mir-30 in BT-ICs inhibits their self-renewal capacity by reducing Ubc9 and induces apoptosis through silencing ITGB3 breast cancer hsa-miR-30c-5p ITGB3 0.021222006155897 0.886366656528128 -0.160351074378419 0.548393025862139 miRNAWalker2_validate;mirMAP;miRNATAP -0.499943731212163 1.04099519567829e-10 NA NA NA hsa-miR-320a ITGB3 0.801356001806321 4.91397101474502e-09 -0.160351074378419 0.548393025862139 miRanda -0.292607339798222 0.000478682947028315 NA NA NA hsa-miR-320b ITGB3 1.23473838180754 3.04337566045537e-14 -0.160351074378419 0.548393025862139 miRanda -0.186523382896149 0.00759095927031934 NA NA NA hsa-miR-338-3p ITGB3 -0.948755228846395 8.99167125682392e-08 -0.160351074378419 0.548393025862139 miRanda -0.269374488899585 2.96719583268045e-05 27431198 Furthermore we also identified a metastasis related protein integrin β3 ITGB3 as a novel target gene of miR-338 metastasis lung cancer hsa-miR-3607-3p ITGB3 1.01377165357363 9.13355519701165e-05 -0.160351074378419 0.548393025862139 MirTarget;mirMAP;miRNATAP -0.281177274077181 1.52872886261478e-10 NA NA NA hsa-miR-425-5p ITGB3 0.931027421598738 6.46235724408844e-08 -0.160351074378419 0.548393025862139 MirTarget -0.335317307647083 4.0835844633639e-07 NA NA NA hsa-miR-429 ITGB3 0.559451508722375 0.00563641638673083 -0.160351074378419 0.548393025862139 miRanda -0.515402242943674 1.19619261182414e-20 NA NA NA hsa-miR-590-3p ITGB3 0.221436901462551 0.0965904764063157 -0.160351074378419 0.548393025862139 PITA;miRanda -0.348435299961168 6.57594087130611e-05 NA NA NA hsa-miR-590-5p ITGB3 0.763025362395968 3.65305892505623e-09 -0.160351074378419 0.548393025862139 miRanda -0.64659197439604 1.05858058473004e-13 NA NA NA hsa-miR-30a-5p ITGB4 -1.79779915425811 1.93360169837799e-26 1.23080110172502 2.63931625007492e-12 miRNAWalker2_validate -0.281754609360929 8.20641992782776e-11 NA NA NA hsa-miR-335-5p ITGB4 -1.17227779671552 1.49282618530733e-10 1.23080110172502 2.63931625007492e-12 miRNAWalker2_validate -0.160974889159495 0.000123475255786919 NA NA NA hsa-miR-532-5p ITGB4 -0.021857649390892 0.830992272120134 1.23080110172502 2.63931625007492e-12 miRNATAP -0.52724763155565 3.57403870022886e-12 NA NA NA hsa-miR-155-5p ITGB5 0.533437622040649 0.00248671179205372 0.447092111973153 0.000319722883344347 miRNAWalker2_validate -0.220467292668732 2.32926315568984e-13 NA NA NA hsa-miR-374a-3p ITGB5 -0.299190081500425 0.00682975596757891 0.447092111973153 0.000319722883344347 MirTarget -0.16897820610897 0.000607021987860573 NA NA NA hsa-miR-378a-5p ITGB5 -1.31095692407946 2.375328908085e-15 0.447092111973153 0.000319722883344347 MirTarget -0.22348012783256 9.44452507253743e-13 NA NA NA hsa-miR-23b-3p ITGB6 -0.497563803223134 3.31483353357535e-05 0.7968558359466 0.0020929860969817 MirTarget -0.328007376816465 0.000495430802849198 NA NA NA hsa-miR-335-5p ITGB6 -1.17227779671552 1.49282618530733e-10 0.7968558359466 0.0020929860969817 miRNAWalker2_validate -0.244862728552586 5.27879207833846e-05 NA NA NA hsa-miR-33a-3p ITGB6 0.20371038027126 0.212335697664505 0.7968558359466 0.0020929860969817 mirMAP -0.203634845466979 0.00387224030784476 NA NA NA hsa-miR-130a-3p ITGB8 0.67051191119964 4.89747518735144e-06 0.347878744029529 0.045084889788209 MirTarget;miRNATAP -0.243413977235905 1.73216601824886e-06 NA NA NA hsa-miR-139-5p ITGB8 -1.46099200329485 7.85040381494472e-22 0.347878744029529 0.045084889788209 PITA;miRanda;miRNATAP -0.275669651621227 5.1932167866457e-09 NA NA NA hsa-miR-17-5p ITGB8 1.41924888736771 2.75805544953758e-18 0.347878744029529 0.045084889788209 MirTarget;TargetScan;miRNATAP -0.162968457903736 0.000281783476637908 NA NA NA hsa-miR-181a-5p ITGB8 0.819060835827404 1.38616688310277e-13 0.347878744029529 0.045084889788209 miRNATAP -0.234173101094207 0.00047539165298388 NA NA NA hsa-miR-181b-5p ITGB8 0.974255518824355 2.64876280203475e-16 0.347878744029529 0.045084889788209 miRNATAP -0.247545102022778 6.19230996570404e-05 NA NA NA hsa-miR-19a-3p ITGB8 1.35800152353624 2.80940447111944e-12 0.347878744029529 0.045084889788209 MirTarget -0.197754983016789 1.61559999980314e-07 NA NA NA hsa-miR-19b-1-5p ITGB8 0.757034032029085 2.99828133413343e-07 0.347878744029529 0.045084889788209 miRNAWalker2_validate -0.134561260545455 0.0080775211801787 NA NA NA hsa-miR-19b-3p ITGB8 0.538732279378089 0.000622008277870679 0.347878744029529 0.045084889788209 MirTarget -0.270563913214854 1.13662404651336e-08 NA NA NA hsa-miR-20a-5p ITGB8 1.1531986665452 1.02385132917958e-11 0.347878744029529 0.045084889788209 MirTarget;miRNATAP -0.189630994654227 1.33702355640501e-05 NA NA NA hsa-miR-26b-5p ITGB8 -0.254478038884324 0.0285227763044636 0.347878744029529 0.045084889788209 MirTarget -0.288124179622019 9.63289342658396e-06 NA NA NA hsa-miR-299-5p ITGB8 -1.92445654064493 1.52402531359074e-16 0.347878744029529 0.045084889788209 PITA -0.132749927222291 2.391813469637e-05 NA NA NA hsa-miR-338-3p ITGB8 -0.948755228846395 8.99167125682392e-08 0.347878744029529 0.045084889788209 miRanda -0.27632456815632 2.5596455938424e-11 NA NA NA hsa-miR-340-3p ITGB8 0.289340144425255 0.0371281333347226 0.347878744029529 0.045084889788209 MirTarget -0.265803082498006 9.56780961125439e-07 NA NA NA hsa-miR-454-3p ITGB8 1.54137391927201 4.15861570449376e-20 0.347878744029529 0.045084889788209 MirTarget -0.197511859156941 4.76922920654371e-06 NA NA NA hsa-miR-542-3p ITGB8 0.643308814904977 8.81635403230104e-07 0.347878744029529 0.045084889788209 miRNATAP -0.317007847602949 2.46724040564087e-08 NA NA NA hsa-miR-576-5p ITGB8 0.940432050128373 6.90227595663302e-12 0.347878744029529 0.045084889788209 PITA -0.225508074510251 2.95956418403811e-05 NA NA NA hsa-miR-106a-5p JAK1 0.67978010057847 0.00221925869726092 -0.0679663395743342 0.461199949404594 MirTarget -0.100854682707181 1.31534376232975e-08 NA NA NA hsa-miR-106b-5p JAK1 0.50378717276868 1.45412404526866e-05 -0.0679663395743342 0.461199949404594 miRNAWalker2_validate;MirTarget -0.206914131837235 1.07605898502248e-09 NA NA NA hsa-miR-15b-5p JAK1 0.85315666454713 3.79816274836297e-12 -0.0679663395743342 0.461199949404594 miRNAWalker2_validate -0.203953135581548 1.01329642270345e-10 NA NA NA hsa-miR-17-5p JAK1 1.41924888736771 2.75805544953758e-18 -0.0679663395743342 0.461199949404594 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.23065214909774 3.99849330265778e-24 NA NA NA hsa-miR-20a-5p JAK1 1.1531986665452 1.02385132917958e-11 -0.0679663395743342 0.461199949404594 MirTarget -0.237250688217439 4.49970281277884e-27 NA NA NA hsa-miR-30b-5p JAK1 -0.400238605368173 0.00346540992719245 -0.0679663395743342 0.461199949404594 MirTarget -0.229823726204053 7.13348406434614e-16 NA NA NA hsa-miR-30c-5p JAK1 0.021222006155897 0.886366656528128 -0.0679663395743342 0.461199949404594 MirTarget -0.166665533010139 4.1183118110881e-10 NA NA NA hsa-miR-30d-5p JAK1 -0.38399848121878 0.000171129616944749 -0.0679663395743342 0.461199949404594 MirTarget -0.123392944276968 0.00168790112521357 NA NA NA hsa-miR-93-5p JAK1 1.61042951896619 5.1280369606967e-24 -0.0679663395743342 0.461199949404594 MirTarget;miRNATAP -0.237852807446343 3.18210459724217e-25 NA NA NA hsa-let-7a-3p JAK2 0.0966652362351867 0.423761916840503 -0.532127619081815 0.00142357520604873 mirMAP;miRNATAP -0.194508661520551 0.00134779157331669 NA NA NA hsa-miR-337-3p JAK2 -1.70091836051933 1.39844536073221e-13 -0.532127619081815 0.00142357520604873 PITA -0.145243586812907 2.24321528756252e-06 NA NA NA hsa-miR-495-3p JAK2 -1.47803501311999 6.88839745293927e-13 -0.532127619081815 0.00142357520604873 mirMAP -0.108487951118978 0.00176426227457955 NA NA NA hsa-miR-149-5p KDR 0.443278770827687 0.0642022866136881 -0.0640531132877142 0.723023281947347 miRNATAP -0.163475530932982 4.97964788050635e-07 NA NA NA hsa-miR-15a-5p KDR 0.783550182002274 2.60699595655907e-11 -0.0640531132877142 0.723023281947347 miRNATAP -0.538223224088053 4.40254709356056e-17 NA NA NA hsa-miR-15b-5p KDR 0.85315666454713 3.79816274836297e-12 -0.0640531132877142 0.723023281947347 miRNATAP -0.23138999639968 0.00022888704644937 NA NA NA hsa-miR-16-5p KDR 0.521122945828175 1.40561786410572e-06 -0.0640531132877142 0.723023281947347 miRTarBase;miRNATAP -0.251278763057448 0.000528972295280267 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2 colorectal cancer hsa-miR-19b-1-5p KDR 0.757034032029085 2.99828133413343e-07 -0.0640531132877142 0.723023281947347 miRNAWalker2_validate -0.39505187814695 1.72509350482592e-14 NA NA NA hsa-miR-200b-3p KDR 0.0717138787925347 0.682858087587209 -0.0640531132877142 0.723023281947347 miRNAWalker2_validate;miRTarBase;TargetScan -0.263698570555775 2.67079529834483e-09 NA NA NA hsa-miR-200c-3p KDR 0.630251054099546 0.000131975031451555 -0.0640531132877142 0.723023281947347 miRNATAP -0.263590197962967 1.99844049333072e-08 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-338-3p KDR -0.948755228846395 8.99167125682392e-08 -0.0640531132877142 0.723023281947347 PITA;miRanda -0.198788405113943 4.97145669026782e-06 NA NA NA hsa-miR-429 KDR 0.559451508722375 0.00563641638673083 -0.0640531132877142 0.723023281947347 PITA;miRanda;miRNATAP -0.27245086358 7.76028904884939e-13 NA NA NA hsa-miR-455-5p KDR 1.408595672323 5.52039116456697e-22 -0.0640531132877142 0.723023281947347 PITA;miRanda;miRNATAP -0.275124811982307 7.69432624809677e-08 NA NA NA hsa-miR-590-3p KDR 0.221436901462551 0.0965904764063157 -0.0640531132877142 0.723023281947347 miRanda -0.170021217673703 0.00410155035555196 NA NA NA hsa-miR-590-5p KDR 0.763025362395968 3.65305892505623e-09 -0.0640531132877142 0.723023281947347 miRanda -0.418670351317141 1.21463513458081e-12 NA NA NA hsa-miR-664a-3p KDR -0.256108763664991 0.0513188660751664 -0.0640531132877142 0.723023281947347 mirMAP -0.192278642957014 0.00135050007055888 NA NA NA hsa-let-7a-3p KIT 0.0966652362351867 0.423761916840503 -1.94230272598042 7.66343751572674e-14 mirMAP -0.530805648762314 2.89869715124166e-08 NA NA NA hsa-miR-130a-3p KIT 0.67051191119964 4.89747518735144e-06 -1.94230272598042 7.66343751572674e-14 miRNATAP -0.667167856595389 1.92070178758509e-18 NA NA NA hsa-miR-130b-3p KIT 1.44628430084411 9.13980959861273e-24 -1.94230272598042 7.66343751572674e-14 miRNATAP -0.265039779940693 0.000589665049470454 NA NA NA hsa-miR-186-5p KIT 0.353452958261612 0.000145058448579496 -1.94230272598042 7.66343751572674e-14 miRNAWalker2_validate -0.467293501801696 0.000190301989939115 NA NA NA hsa-miR-193a-3p KIT 0.22120710726779 0.111827069464729 -1.94230272598042 7.66343751572674e-14 MirTarget;PITA;miRanda;miRNATAP -0.487739386439134 3.68695555599671e-09 NA NA NA hsa-miR-193b-3p KIT 1.72788400801602 3.0722151264559e-21 -1.94230272598042 7.66343751572674e-14 MirTarget;miRNATAP -0.692658869899421 1.05433951210173e-33 NA NA NA hsa-miR-19a-3p KIT 1.35800152353624 2.80940447111944e-12 -1.94230272598042 7.66343751572674e-14 miRTarBase;miRNATAP -0.571419846362028 1.47751427980055e-24 NA NA NA hsa-miR-19b-3p KIT 0.538732279378089 0.000622008277870679 -1.94230272598042 7.66343751572674e-14 miRNATAP -0.570970952645054 1.63739914897172e-15 NA NA NA hsa-miR-205-5p KIT 1.50759485376634 2.0003886738248e-16 -1.94230272598042 7.66343751572674e-14 miRNATAP -0.587985493295641 1.67469371567818e-23 NA NA NA hsa-miR-20a-5p KIT 1.1531986665452 1.02385132917958e-11 -1.94230272598042 7.66343751572674e-14 miRTarBase -0.594280707742389 4.7786339259645e-20 NA NA NA hsa-miR-221-3p KIT 0.410625614724387 0.000741090075261272 -1.94230272598042 7.66343751572674e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.477829275715389 4.5760842543397e-07 NA NA NA hsa-miR-222-3p KIT 1.08197052578759 2.32604040301699e-14 -1.94230272598042 7.66343751572674e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.652707534774401 4.39260036600639e-17 NA NA NA hsa-miR-301a-3p KIT 2.14132004241926 4.46255413526808e-25 -1.94230272598042 7.66343751572674e-14 miRNATAP -0.480331192828765 9.97800204508617e-21 NA NA NA hsa-miR-338-3p KIT -0.948755228846395 8.99167125682392e-08 -1.94230272598042 7.66343751572674e-14 miRanda -0.171133051059791 0.0081865504749672 NA NA NA hsa-miR-429 KIT 0.559451508722375 0.00563641638673083 -1.94230272598042 7.66343751572674e-14 miRNATAP -0.228014205545458 6.51900324316195e-05 NA NA NA hsa-miR-450b-5p KIT 1.25529820885833 1.18847120528666e-15 -1.94230272598042 7.66343751572674e-14 MirTarget -0.291115708652542 5.00922351814219e-05 NA NA NA hsa-miR-454-3p KIT 1.54137391927201 4.15861570449376e-20 -1.94230272598042 7.66343751572674e-14 miRNATAP -0.517228407790827 1.64848588897275e-15 NA NA NA hsa-miR-501-5p KIT 1.02806906860218 1.63456814370548e-09 -1.94230272598042 7.66343751572674e-14 miRNATAP -0.326946873571749 1.29019266854981e-06 NA NA NA hsa-miR-505-3p KIT 0.912823669571645 4.0549774967148e-13 -1.94230272598042 7.66343751572674e-14 MirTarget;miRNATAP -0.54950302247173 7.47869762736026e-10 NA NA NA hsa-miR-671-5p KIT 1.90920358947989 6.8158317757852e-31 -1.94230272598042 7.66343751572674e-14 MirTarget -0.56193165932573 1.82858025190679e-18 NA NA NA hsa-miR-181b-5p KITLG 0.974255518824355 2.64876280203475e-16 -0.0193319950817896 0.910440302136666 MirTarget -0.205934809929244 0.000766216163444943 NA NA NA hsa-miR-186-5p KITLG 0.353452958261612 0.000145058448579496 -0.0193319950817896 0.910440302136666 mirMAP -0.274912026680401 0.000659953994959615 NA NA NA hsa-miR-19a-3p KITLG 1.35800152353624 2.80940447111944e-12 -0.0193319950817896 0.910440302136666 mirMAP -0.236370729566127 1.80207686104105e-10 NA NA NA hsa-miR-19b-3p KITLG 0.538732279378089 0.000622008277870679 -0.0193319950817896 0.910440302136666 mirMAP -0.270985426975178 7.06299179865195e-09 NA NA NA hsa-miR-205-5p KITLG 1.50759485376634 2.0003886738248e-16 -0.0193319950817896 0.910440302136666 mirMAP -0.103484329118169 0.0089552595904125 NA NA NA hsa-miR-22-5p KITLG 0.706731861922839 3.44318705980007e-07 -0.0193319950817896 0.910440302136666 MirTarget -0.208566379800274 9.19862339042177e-05 NA NA NA hsa-miR-26b-5p KITLG -0.254478038884324 0.0285227763044636 -0.0193319950817896 0.910440302136666 mirMAP -0.227552705417535 0.000423360021058634 NA NA NA hsa-miR-30b-5p KITLG -0.400238605368173 0.00346540992719245 -0.0193319950817896 0.910440302136666 mirMAP -0.149150982860689 0.00636561554116263 NA NA NA hsa-miR-30c-5p KITLG 0.021222006155897 0.886366656528128 -0.0193319950817896 0.910440302136666 mirMAP -0.201995543331669 6.02216856080911e-05 NA NA NA hsa-miR-452-3p KITLG 1.09618110917892 2.21867884261816e-07 -0.0193319950817896 0.910440302136666 mirMAP -0.117729504729521 0.000732390290750137 NA NA NA hsa-miR-501-5p KITLG 1.02806906860218 1.63456814370548e-09 -0.0193319950817896 0.910440302136666 PITA;mirMAP -0.220077381752313 4.0509381785104e-07 NA NA NA hsa-miR-589-3p KITLG 1.59559692667315 6.2886410639161e-15 -0.0193319950817896 0.910440302136666 mirMAP -0.127790628440224 0.000548131008223528 NA NA NA hsa-miR-664a-3p KITLG -0.256108763664991 0.0513188660751664 -0.0193319950817896 0.910440302136666 mirMAP -0.215610172367544 0.000152396947394066 NA NA NA hsa-let-7a-3p KRAS 0.0966652362351867 0.423761916840503 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.136931356508913 0.000135436448739821 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-miR-126-3p KRAS 0.0487843863772834 0.730130847436008 -0.0421192166497262 0.67210141138451 miRNAWalker2_validate;miRTarBase -0.115990819317181 0.0001500081257996 22845403 miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK pancreatic cancer hsa-miR-155-5p KRAS 0.533437622040649 0.00248671179205372 -0.0421192166497262 0.67210141138451 miRNAWalker2_validate;miRNATAP -0.106787251340147 1.12687232356945e-05 NA NA NA hsa-miR-181a-5p KRAS 0.819060835827404 1.38616688310277e-13 -0.0421192166497262 0.67210141138451 miRNAWalker2_validate -0.206488916827338 5.30264645500736e-08 24098024;27517749;26124189 The KRAS mutational status was determined by pyrosequencing and miR-181a expression was measured by quantitative RT-PCR in CRC tumour tissue and corresponding non-neoplastic colon tissue;Here we report that miR-181a directly binds to 3'-untranslated regions UTRs; downregulates KRAS NRAS and MAPK1; and decreases AML growth; The delivery of miR-181a mimics to target AML cells using transferrin-targeting lipopolyplex nanoparticles NP increased mature miR-181a; downregulated KRAS NRAS and MAPK1; and resulted in decreased phosphorylation of the downstream RAS effectors;MiR 181a 5p inhibits cell proliferation and migration by targeting Kras in non small cell lung cancer A549 cells; Luciferase activity assay results demonstrated that two binding sites of Kras could be directly targeted by miR-181a-5p; Furthermore Kras was down-regulated by miR-181a-5p at both transcriptional and translational levels; SiRNA-mediated Kras down-regulation could mimic the effects of miR-181a-5p mimic in A549 cells; Our findings suggest that miR-181a-5p plays a potential role in tumor suppression by partially targeting Kras and has the potential therapeutic application in NSCLC patients ;; colorectal cancer;acute myeloid leukemia;lung squamous cell cancer hsa-miR-186-5p KRAS 0.353452958261612 0.000145058448579496 -0.0421192166497262 0.67210141138451 mirMAP -0.20957782293178 6.43868544074746e-06 NA NA NA hsa-miR-30a-5p KRAS -1.79779915425811 1.93360169837799e-26 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.109380981252874 6.01372957790632e-06 NA NA NA hsa-miR-30b-5p KRAS -0.400238605368173 0.00346540992719245 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.14630304008033 3.12182870258392e-06 NA NA NA hsa-miR-30c-5p KRAS 0.021222006155897 0.886366656528128 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.160986192000454 2.5135861758379e-08 22701724 Deregulated miRNAs in hereditary breast cancer revealed a role for miR 30c in regulating KRAS oncogene; In particular we experimentally validated KRAS as a miR-30c target; Luciferase assays confirmed that miR-30c binds the 3'UTR of KRAS transcripts and expression of pre-miR-30c down-regulated KRAS mRNA and protein; In addition we provide evidence that KRAS is a target of miR-30c and that this miRNA suppresses breast cancer cell growth potentially through inhibition of KRAS signaling breast cancer hsa-miR-501-3p KRAS 0.820141346319976 1.74562930463389e-08 -0.0421192166497262 0.67210141138451 MirTarget;PITA;TargetScan;miRNATAP -0.107029284719557 0.000261941382230982 NA NA NA hsa-miR-542-3p KRAS 0.643308814904977 8.81635403230104e-07 -0.0421192166497262 0.67210141138451 miRanda -0.137689698022332 2.50585208964673e-05 NA NA NA hsa-miR-590-3p LAMA2 0.221436901462551 0.0965904764063157 -0.668763906211971 0.0074979937909837 miRanda -0.486315219619538 2.12271598666422e-09 NA NA NA hsa-miR-217 LAMA3 -1.35391381055929 2.42394951427902e-09 2.29750257159021 3.13418480482589e-17 PITA;miRanda -0.2315655688482 1.17411713415295e-05 NA NA NA hsa-miR-26b-5p LAMA3 -0.254478038884324 0.0285227763044636 2.29750257159021 3.13418480482589e-17 miRNAWalker2_validate -0.406479205328374 0.000119702131075166 NA NA NA hsa-miR-205-3p LAMA4 1.2960640797621 5.80786479909147e-11 1.17672500600721 8.05537530181132e-10 MirTarget -0.329574668499717 8.37601864149503e-16 NA NA NA hsa-miR-338-3p LAMA4 -0.948755228846395 8.99167125682392e-08 1.17672500600721 8.05537530181132e-10 miRanda -0.209572674978874 8.22697757772659e-06 NA NA NA hsa-miR-429 LAMA4 0.559451508722375 0.00563641638673083 1.17672500600721 8.05537530181132e-10 miRanda -0.382858387938588 2.02438293898391e-21 NA NA NA hsa-miR-590-3p LAMA4 0.221436901462551 0.0965904764063157 1.17672500600721 8.05537530181132e-10 miRanda -0.269895657002519 2.21135332859435e-05 NA NA NA hsa-miR-590-5p LAMA4 0.763025362395968 3.65305892505623e-09 1.17672500600721 8.05537530181132e-10 MirTarget;miRanda -0.389263439966944 1.18473514139386e-09 NA NA NA hsa-miR-93-3p LAMA4 1.69225547123293 1.50964095575087e-25 1.17672500600721 8.05537530181132e-10 miRNAWalker2_validate -0.146383776093693 0.00334756234884182 NA NA NA hsa-miR-16-5p LAMB1 0.521122945828175 1.40561786410572e-06 1.34688018886223 5.40790324078751e-20 miRNAWalker2_validate -0.18324778697546 0.00286887928260106 NA NA NA hsa-miR-375 LAMB1 -4.24070205340868 7.48368361454041e-28 1.34688018886223 5.40790324078751e-20 miRanda -0.136418902317529 3.87557184995071e-18 NA NA NA hsa-miR-500a-3p LAMB1 0.457959128173392 0.000691656736597067 1.34688018886223 5.40790324078751e-20 miRNAWalker2_validate -0.138882581073231 0.0048410553482472 NA NA NA hsa-miR-196b-5p LAMB2 3.78958266598891 1.12771732893771e-44 -0.537879784295788 0.000123578600325887 miRNAWalker2_validate -0.118189148378517 7.95079830860775e-09 NA NA NA hsa-miR-29b-1-5p LAMB2 1.39669186711325 4.36960953138935e-11 -0.537879784295788 0.000123578600325887 MirTarget -0.145888042411353 2.2846064934896e-07 NA NA NA hsa-miR-484 LAMB2 0.918280909791707 1.39168306854263e-14 -0.537879784295788 0.000123578600325887 miRNAWalker2_validate -0.284882736058328 1.03350604550811e-08 NA NA NA hsa-miR-218-5p LAMB3 -1.0725338636959 3.61493686604269e-09 1.73708758929963 3.47882028770406e-18 miRNAWalker2_validate;miRTarBase -0.226499695739234 3.05711846830132e-06 23159910;25337271;20163849;23320911;17998940 Furthermore we focused on LAMB3 which has a miR-218 target site and gene expression studies and luciferase reporter assays showed that LAMB3 was directly regulated by miR-218;The aim of this study was to investigate whether polymorphisms in miR-218 LAMB3 pathway were associated with the risk and prognosis of esophageal squamous cell carcinoma ESCC;Polymorphisms involved in the miR 218 LAMB3 pathway and susceptibility of cervical cancer a case control study in Chinese women; MicroRNA-218 miR-218 can target laminin-5 beta3 LAMB3 but suppressed by HPV-16 E6 protein;However this association was not observed for the miR-218 binding site SNP rs2566 on LAMB3;We also demonstrate that the epithelial cell-specific marker LAMB3 is a target of miR-218; We also show that LAMB3 expression is increased in the presence of the HPV-16 E6 oncogene and this effect is mediated through miR-218 ;worse prognosis;;; head and neck cancer;esophageal cancer;cervical and endocervical cancer;cervical and endocervical cancer;cervical and endocervical cancer hsa-miR-362-3p LAMB3 -0.697212068252854 2.61718493418184e-06 1.73708758929963 3.47882028770406e-18 MirTarget;miRanda -0.20613930484956 0.000651296072390836 NA NA NA hsa-miR-421 LAMB4 0.945488088619653 2.35762398527362e-09 -3.13015848139761 1.2200271923016e-16 miRanda -0.331524387805154 0.00178323840461916 NA NA NA hsa-miR-590-3p LAMB4 0.221436901462551 0.0965904764063157 -3.13015848139761 1.2200271923016e-16 miRanda -0.368445842927742 0.00400978761515059 NA NA NA hsa-miR-10b-5p LAMC1 -0.582989331935508 4.56688330655626e-06 1.05890878482494 2.257399205376e-15 miRNAWalker2_validate -0.293028300160824 2.14537995945773e-10 NA NA NA hsa-miR-126-5p LAMC1 -0.953529188793816 7.91719143295591e-16 1.05890878482494 2.257399205376e-15 mirMAP -0.146250052814606 0.00304041572203498 NA NA NA hsa-miR-139-5p LAMC1 -1.46099200329485 7.85040381494472e-22 1.05890878482494 2.257399205376e-15 miRanda -0.134197539899556 0.000371884753681707 NA NA NA hsa-miR-140-5p LAMC1 -0.412389003031485 0.000136051708543369 1.05890878482494 2.257399205376e-15 MirTarget;PITA;miRanda;miRNATAP -0.148367508622965 0.00750948779648523 NA NA NA hsa-miR-15a-5p LAMC1 0.783550182002274 2.60699595655907e-11 1.05890878482494 2.257399205376e-15 MirTarget -0.210957811494347 2.43262257168465e-05 NA NA NA hsa-miR-200b-3p LAMC1 0.0717138787925347 0.682858087587209 1.05890878482494 2.257399205376e-15 MirTarget;TargetScan -0.239636688992121 8.06816514307707e-13 NA NA NA hsa-miR-200c-3p LAMC1 0.630251054099546 0.000131975031451555 1.05890878482494 2.257399205376e-15 MirTarget;miRNATAP -0.117449801210543 0.0011392486115475 NA NA NA hsa-miR-29a-3p LAMC1 -1.26881270980079 2.82496991513463e-22 1.05890878482494 2.257399205376e-15 MirTarget;miRNATAP -0.182182481655805 3.23106325370556e-05 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29b-3p LAMC1 -0.110721443686039 0.511264554091106 1.05890878482494 2.257399205376e-15 MirTarget;miRNATAP -0.289523360544155 5.30899601654208e-17 NA NA NA hsa-miR-29c-3p LAMC1 -2.08166260448948 8.3238369390898e-24 1.05890878482494 2.257399205376e-15 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.171537215865158 2.81451371739003e-10 NA NA NA hsa-miR-338-3p LAMC1 -0.948755228846395 8.99167125682392e-08 1.05890878482494 2.257399205376e-15 MirTarget;miRanda -0.213129405573725 8.08868846269364e-11 NA NA NA hsa-miR-33a-3p LAMC1 0.20371038027126 0.212335697664505 1.05890878482494 2.257399205376e-15 mirMAP -0.125694932486404 0.000726962280381846 NA NA NA hsa-miR-362-3p LAMC1 -0.697212068252854 2.61718493418184e-06 1.05890878482494 2.257399205376e-15 miRanda -0.210874854741665 1.20601271487835e-07 NA NA NA hsa-miR-374a-5p LAMC1 -0.621903385111545 6.61791773205282e-12 1.05890878482494 2.257399205376e-15 mirMAP -0.185117068177564 0.00469178058840229 NA NA NA hsa-miR-374b-5p LAMC1 -0.288413933608091 0.0041474558664058 1.05890878482494 2.257399205376e-15 mirMAP -0.175788655418089 0.00332261346105154 NA NA NA hsa-miR-429 LAMC1 0.559451508722375 0.00563641638673083 1.05890878482494 2.257399205376e-15 MirTarget;PITA;miRanda;miRNATAP -0.178841287498999 8.18111533845926e-10 NA NA NA hsa-miR-497-5p LAMC1 -0.966244470847844 5.26505649147857e-12 1.05890878482494 2.257399205376e-15 MirTarget;miRNATAP -0.154410114008189 0.000224045134149072 NA NA NA hsa-miR-590-3p LAMC1 0.221436901462551 0.0965904764063157 1.05890878482494 2.257399205376e-15 PITA;miRanda;mirMAP -0.163782871528416 0.000270224421784628 NA NA NA hsa-miR-7-1-3p LAMC1 1.13646121619622 1.49823237535933e-14 1.05890878482494 2.257399205376e-15 mirMAP -0.147394482197662 0.000183304189980798 NA NA NA hsa-miR-92a-3p LAMC1 0.994679542307232 1.32587679156217e-16 1.05890878482494 2.257399205376e-15 miRNAWalker2_validate -0.12901393383078 0.00783731501892839 NA NA NA hsa-miR-942-5p LAMC1 0.678652135586536 2.58063518495056e-07 1.05890878482494 2.257399205376e-15 MirTarget -0.165843346056552 0.000226606398377497 NA NA NA hsa-miR-125b-5p LAMC2 -0.993460109818276 5.07736727659894e-12 3.46594419371739 1.64686476935167e-33 MirTarget -0.673661055907174 4.33755898576263e-14 NA NA NA hsa-miR-199b-5p LAMC2 -1.08432682485992 7.68241801134089e-10 3.46594419371739 1.64686476935167e-33 miRNAWalker2_validate;miRTarBase -0.25630394416789 0.000592410256289566 NA NA NA hsa-miR-338-3p LAMC2 -0.948755228846395 8.99167125682392e-08 3.46594419371739 1.64686476935167e-33 miRanda -0.211309253532861 0.004599363635615 NA NA NA hsa-miR-375 LAMC2 -4.24070205340868 7.48368361454041e-28 3.46594419371739 1.64686476935167e-33 miRanda -0.234032255031293 2.27735611964486e-13 NA NA NA hsa-miR-660-5p LAMC2 -0.202705992887645 0.101093376073573 3.46594419371739 1.64686476935167e-33 MirTarget -0.677538343077072 2.60620388289144e-10 NA NA NA hsa-miR-30b-5p LAMC3 -0.400238605368173 0.00346540992719245 0.194810037729386 0.457655830002623 mirMAP -0.251284090873704 0.00259776870360324 NA NA NA hsa-miR-16-2-3p LPAR1 1.1567130855258 1.01867256952189e-14 -0.678830468106056 0.000292828835086657 MirTarget;mirMAP -0.357437231323386 1.07726424991718e-11 NA NA NA hsa-miR-188-5p LPAR1 0.559328953885106 0.000430338888594543 -0.678830468106056 0.000292828835086657 MirTarget -0.15802552660059 0.00223786602488005 NA NA NA hsa-miR-200b-3p LPAR1 0.0717138787925347 0.682858087587209 -0.678830468106056 0.000292828835086657 MirTarget;TargetScan -0.221508072718552 1.93118413495274e-06 NA NA NA hsa-miR-200c-3p LPAR1 0.630251054099546 0.000131975031451555 -0.678830468106056 0.000292828835086657 miRNAWalker2_validate;MirTarget;miRNATAP -0.212350519116888 1.66702710602824e-05 NA NA NA hsa-miR-205-5p LPAR1 1.50759485376634 2.0003886738248e-16 -0.678830468106056 0.000292828835086657 MirTarget -0.422319319007927 2.69201263727507e-24 NA NA NA hsa-miR-20a-3p LPAR1 1.34885093664027 2.07697464119202e-12 -0.678830468106056 0.000292828835086657 MirTarget -0.254252105496302 7.11655927693536e-10 NA NA NA hsa-miR-26b-5p LPAR1 -0.254478038884324 0.0285227763044636 -0.678830468106056 0.000292828835086657 miRNATAP -0.233004550169032 0.00101662092198882 NA NA NA hsa-miR-324-5p LPAR1 1.66709479707179 1.45961450445769e-23 -0.678830468106056 0.000292828835086657 miRanda -0.262948184676438 1.64898946080563e-08 NA NA NA hsa-miR-339-5p LPAR1 1.07771430326938 2.45772601859307e-09 -0.678830468106056 0.000292828835086657 miRanda -0.250555840633037 1.47879064388153e-08 NA NA NA hsa-miR-342-3p LPAR1 0.99756868977753 9.28499866272332e-10 -0.678830468106056 0.000292828835086657 miRanda -0.19712198681372 6.65815444828478e-05 NA NA NA hsa-miR-429 LPAR1 0.559451508722375 0.00563641638673083 -0.678830468106056 0.000292828835086657 MirTarget;miRanda;miRNATAP -0.238325504620314 2.50943397179062e-09 NA NA NA hsa-miR-501-5p LPAR1 1.02806906860218 1.63456814370548e-09 -0.678830468106056 0.000292828835086657 MirTarget;miRNATAP -0.177328967583593 0.000217252173354834 NA NA NA hsa-miR-576-5p LPAR1 0.940432050128373 6.90227595663302e-12 -0.678830468106056 0.000292828835086657 mirMAP -0.306057748474417 1.50647027599142e-07 NA NA NA hsa-miR-671-5p LPAR1 1.90920358947989 6.8158317757852e-31 -0.678830468106056 0.000292828835086657 MirTarget -0.170632305478854 0.000256658801802622 NA NA NA hsa-miR-7-1-3p LPAR1 1.13646121619622 1.49823237535933e-14 -0.678830468106056 0.000292828835086657 MirTarget -0.241255166927089 7.55681304560539e-06 NA NA NA hsa-miR-143-3p LPAR2 -1.33760181792708 4.15335119989612e-12 0.761430727609144 5.57469048431547e-13 miRNATAP -0.174228363156917 7.88116575012544e-14 NA NA NA hsa-miR-299-5p LPAR2 -1.92445654064493 1.52402531359074e-16 0.761430727609144 5.57469048431547e-13 miRNATAP -0.130320334930474 1.33726742387888e-11 NA NA NA hsa-miR-654-3p LPAR2 -1.77960431554497 1.76486415439529e-14 0.761430727609144 5.57469048431547e-13 MirTarget -0.108115135736907 2.93268553052712e-08 NA NA NA hsa-miR-106b-5p LPAR3 0.50378717276868 1.45412404526866e-05 0.714067632418426 0.00346033982939574 mirMAP -0.28010847887657 0.00224706554893022 NA NA NA hsa-miR-28-5p LPAR3 -0.026996999089909 0.733047113251652 0.714067632418426 0.00346033982939574 miRanda -0.550510015070356 5.78542868319031e-05 NA NA NA hsa-miR-186-5p LPAR5 0.353452958261612 0.000145058448579496 -0.0320988428851399 0.839238270413524 MirTarget -0.357405220206812 1.31626817932938e-06 NA NA NA hsa-miR-24-3p LPAR6 0.13115428390042 0.203891651275156 -1.14627883397791 6.23352662308395e-11 MirTarget -0.385834716159582 3.1782572468028e-07 NA NA NA hsa-miR-30c-5p MAP2K1 0.021222006155897 0.886366656528128 0.142764606305617 0.0590440739007102 miRNAWalker2_validate -0.10505314483532 1.85439886243956e-06 NA NA NA hsa-miR-34a-5p MAP2K1 -0.117372471043915 0.364001947180738 0.142764606305617 0.0590440739007102 miRNAWalker2_validate;miRTarBase -0.123625149360131 1.05490001381872e-06 NA NA NA hsa-let-7b-5p MAP2K2 -0.2489842756826 0.0211384499461719 -0.140639001206001 0.11730805163915 miRNAWalker2_validate -0.227132527741912 2.24643017568319e-10 NA NA NA hsa-miR-130a-3p MAPK1 0.67051191119964 4.89747518735144e-06 -0.0253189255173565 0.755655647597946 mirMAP -0.119879003954416 4.21355197025158e-07 NA NA NA hsa-miR-140-5p MAPK1 -0.412389003031485 0.000136051708543369 -0.0253189255173565 0.755655647597946 miRanda -0.106820947603036 0.00107357303022432 NA NA NA hsa-miR-16-2-3p MAPK1 1.1567130855258 1.01867256952189e-14 -0.0253189255173565 0.755655647597946 mirMAP -0.118882902026294 1.87389146405289e-07 NA NA NA hsa-miR-19a-3p MAPK1 1.35800152353624 2.80940447111944e-12 -0.0253189255173565 0.755655647597946 mirMAP -0.108060075233242 6.73894767696324e-10 NA NA NA hsa-miR-19b-3p MAPK1 0.538732279378089 0.000622008277870679 -0.0253189255173565 0.755655647597946 mirMAP -0.153151975431285 2.83628955522989e-12 NA NA NA hsa-miR-24-1-5p MAPK1 -0.0503110566834755 0.742860080224713 -0.0253189255173565 0.755655647597946 mirMAP -0.116961525723256 3.20301669196585e-07 NA NA NA hsa-miR-29a-5p MAPK1 0.323252792625584 0.0370417231222825 -0.0253189255173565 0.755655647597946 mirMAP -0.100820598289556 8.60387631678624e-06 NA NA NA hsa-miR-29b-2-5p MAPK1 -0.502720326849742 0.000730448246894952 -0.0253189255173565 0.755655647597946 mirMAP -0.143966940664653 6.76991395724673e-10 NA NA NA hsa-miR-29b-3p MAPK1 -0.110721443686039 0.511264554091106 -0.0253189255173565 0.755655647597946 mirMAP -0.155562785937532 3.13794270245465e-14 NA NA NA hsa-miR-30b-5p MAPK1 -0.400238605368173 0.00346540992719245 -0.0253189255173565 0.755655647597946 mirMAP -0.174014396815711 6.15963591886978e-12 NA NA NA hsa-miR-30c-5p MAPK1 0.021222006155897 0.886366656528128 -0.0253189255173565 0.755655647597946 mirMAP -0.16816380351527 6.00043626518046e-13 NA NA NA hsa-miR-30d-3p MAPK1 -0.577371911152798 2.02950840095287e-06 -0.0253189255173565 0.755655647597946 mirMAP -0.122142266216853 2.26778585246636e-05 NA NA NA hsa-miR-32-5p MAPK1 -0.317310201890053 0.0102525324475293 -0.0253189255173565 0.755655647597946 mirMAP -0.118206616474112 3.38014161673994e-05 NA NA NA hsa-miR-320a MAPK1 0.801356001806321 4.91397101474502e-09 -0.0253189255173565 0.755655647597946 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.125451646590753 6.80368047080733e-07 NA NA NA hsa-miR-338-3p MAPK1 -0.948755228846395 8.99167125682392e-08 -0.0253189255173565 0.755655647597946 miRanda -0.129835880343114 1.75257870680844e-11 NA NA NA hsa-miR-342-3p MAPK1 0.99756868977753 9.28499866272332e-10 -0.0253189255173565 0.755655647597946 miRanda;mirMAP -0.169189955454587 3.43413416819006e-16 NA NA NA hsa-miR-34a-5p MAPK1 -0.117372471043915 0.364001947180738 -0.0253189255173565 0.755655647597946 mirMAP -0.233668876576953 1.32503113597025e-18 NA NA NA hsa-miR-362-3p MAPK1 -0.697212068252854 2.61718493418184e-06 -0.0253189255173565 0.755655647597946 mirMAP -0.110141441408008 2.93292282524057e-06 NA NA NA hsa-miR-362-5p MAPK1 0.41089772861323 0.0404254902071382 -0.0253189255173565 0.755655647597946 mirMAP -0.144103835470426 3.00694449777536e-17 NA NA NA hsa-miR-374a-3p MAPK1 -0.299190081500425 0.00682975596757891 -0.0253189255173565 0.755655647597946 mirMAP -0.110281311853038 0.000567634401408648 NA NA NA hsa-miR-374b-5p MAPK1 -0.288413933608091 0.0041474558664058 -0.0253189255173565 0.755655647597946 mirMAP -0.193539977082972 2.99670270207311e-08 NA NA NA hsa-miR-454-3p MAPK1 1.54137391927201 4.15861570449376e-20 -0.0253189255173565 0.755655647597946 mirMAP -0.134566799939584 1.33034028771569e-11 NA NA NA hsa-miR-500a-3p MAPK1 0.457959128173392 0.000691656736597067 -0.0253189255173565 0.755655647597946 mirMAP -0.181280312300052 1.44783347897454e-12 NA NA NA hsa-miR-501-3p MAPK1 0.820141346319976 1.74562930463389e-08 -0.0253189255173565 0.755655647597946 mirMAP -0.113690992046206 1.83281067549205e-06 NA NA NA hsa-miR-501-5p MAPK1 1.02806906860218 1.63456814370548e-09 -0.0253189255173565 0.755655647597946 mirMAP -0.102516454465174 5.70704874257852e-07 NA NA NA hsa-miR-502-3p MAPK1 -0.165138869760313 0.106881047403914 -0.0253189255173565 0.755655647597946 mirMAP -0.118442041096273 0.000641376645364786 NA NA NA hsa-miR-505-3p MAPK1 0.912823669571645 4.0549774967148e-13 -0.0253189255173565 0.755655647597946 mirMAP -0.112388892923579 4.07425901957411e-05 NA NA NA hsa-miR-660-5p MAPK1 -0.202705992887645 0.101093376073573 -0.0253189255173565 0.755655647597946 mirMAP -0.195287313401534 3.91978206929352e-12 NA NA NA hsa-miR-320b MAPK3 1.23473838180754 3.04337566045537e-14 -0.858383500175909 4.87731698141196e-21 miRNAWalker2_validate -0.150409382751881 7.4168687441981e-10 NA NA NA hsa-miR-34a-5p MAPK3 -0.117372471043915 0.364001947180738 -0.858383500175909 4.87731698141196e-21 miRNAWalker2_validate -0.142473103912921 8.01686085043296e-06 NA NA NA hsa-miR-423-3p MAPK3 1.20230884409188 2.57129723627633e-23 -0.858383500175909 4.87731698141196e-21 miRNAWalker2_validate -0.111095021124406 0.000694439178470412 NA NA NA hsa-miR-423-5p MAPK3 0.60141781325829 1.62940950644999e-07 -0.858383500175909 4.87731698141196e-21 miRNATAP -0.162814696094577 4.59419685322422e-06 NA NA NA hsa-miR-542-3p MAPK3 0.643308814904977 8.81635403230104e-07 -0.858383500175909 4.87731698141196e-21 miRanda -0.109224164762627 0.000481993746155519 NA NA NA hsa-miR-106b-5p MCL1 0.50378717276868 1.45412404526866e-05 -0.138607194358428 0.0880409496909249 MirTarget;miRNATAP -0.106903933422902 0.000409424231647594 NA NA NA hsa-miR-125b-5p MCL1 -0.993460109818276 5.07736727659894e-12 -0.138607194358428 0.0880409496909249 miRTarBase;MirTarget;miRNATAP -0.114461237778782 1.66633603365683e-06 22942733;25894378;26504803 The ectopic expression of miR-125b reduced the cellular proliferation and cell cycle progression of HCC cells by targeting Mcl-1 and IL6R;However the overexpression of miR-125b did not influence the doxorubicin accumulation but downregulated the myeloid cell leukemia-1 Mcl-1 levels which may be the mechanism of apoptosis induction caused by doxorubicin combining with miR-125b in MCF-7/DR cells; Furthermore luciferase reporter assay proved that Mcl-1 is the target of miR-125b;miR 125b Suppresses Proliferation and Invasion by Targeting MCL1 in Gastric Cancer; miR-125b elicits these responses by directly targeting MCL1 myeloid cell leukemia 1 which results in a marked reduction in MCL1 expression progression;;drug resistance liver cancer;breast cancer;gastric cancer hsa-miR-361-5p MCL1 0.0803683277369505 0.314043140368058 -0.138607194358428 0.0880409496909249 miRanda -0.169522694821961 0.000157656692879564 NA NA NA hsa-miR-145-5p MDM2 -0.46917511594055 0.000685297625493134 -0.187608646962063 0.0757851997933277 miRNAWalker2_validate -0.120282167205982 0.000285646785971262 NA NA NA hsa-miR-181a-2-3p MDM2 0.562132917934234 4.79313448225408e-05 -0.187608646962063 0.0757851997933277 mirMAP -0.183010150101776 2.34295977089442e-08 NA NA NA hsa-miR-450a-5p MDM2 1.74695686398479 4.62583996044297e-22 -0.187608646962063 0.0757851997933277 mirMAP -0.133291140860781 3.19028333188365e-08 NA NA NA hsa-miR-139-5p MET -1.46099200329485 7.85040381494472e-22 1.10982494733612 1.35440527522278e-11 miRanda -0.137911326125565 0.00274646767783672 NA NA NA hsa-miR-217 MET -1.35391381055929 2.42394951427902e-09 1.10982494733612 1.35440527522278e-11 miRanda -0.118418579913743 0.000173493783908158 NA NA NA hsa-miR-23b-3p MET -0.497563803223134 3.31483353357535e-05 1.10982494733612 1.35440527522278e-11 miRNAWalker2_validate;miRTarBase -0.346144586318372 8.24079659186336e-09 19490101 MicroRNA 23b mediates urokinase and c met downmodulation and a decreased migration of human hepatocellular carcinoma cells; In the present study to understand whether the expression of these genes might be coregulated by specific microRNAs miRs in human cells we predicted that Homo sapiens microRNA-23b could recognize two sites in the 3'-UTR of uPA and four sites in the c-met 3'-UTR by the algorithm pictar; The evidence obtained shows that overexpression of miR-23b leads to uPA and c-met downregulation and to decreased migration and proliferation abilities of HCC cells liver cancer hsa-miR-30a-3p MET -2.26144364746452 8.12421214153823e-31 1.10982494733612 1.35440527522278e-11 mirMAP -0.16920735224763 1.1418377506011e-06 NA NA NA hsa-miR-30a-5p MET -1.79779915425811 1.93360169837799e-26 1.10982494733612 1.35440527522278e-11 miRNAWalker2_validate -0.270438642104152 2.01456359758425e-11 NA NA NA hsa-miR-30d-3p MET -0.577371911152798 2.02950840095287e-06 1.10982494733612 1.35440527522278e-11 mirMAP -0.362108862532689 8.77989123375445e-10 NA NA NA hsa-miR-30e-3p MET -0.890635378639789 1.65740480611339e-16 1.10982494733612 1.35440527522278e-11 mirMAP -0.354613109014861 5.61950974192057e-08 NA NA NA hsa-miR-320a MET 0.801356001806321 4.91397101474502e-09 1.10982494733612 1.35440527522278e-11 miRNAWalker2_validate -0.147408399040599 0.00512060005516367 NA NA NA hsa-miR-34a-5p MET -0.117372471043915 0.364001947180738 1.10982494733612 1.35440527522278e-11 miRNAWalker2_validate;miRTarBase -0.431568259408799 6.1582474498291e-15 23243217;26104764;22457788;23593387;19006648;19773441;19029026 Detection of miR 34a promoter methylation in combination with elevated expression of c Met and β catenin predicts distant metastasis of colon cancer; Using a case-control study design of 94 primary colon cancer samples with and without liver metastases we determined CpG methylation frequencies of miR-34a and miR-34b/c promoters expression of miR-34a and its targets c-Met Snail and β-catenin and their prognostic value; Decreased miR-34a expression was associated with upregulation of c-Met Snail and β-catenin protein levels P = 0.031 0.132 and 0.004 which were associated with distant metastases P = 0.001 0.017 and 0.005; In a confounder-adjusted multivariate regression model miR-34a methylation high c-Met and β-catenin levels provided the most significant prognostic information about metastases to the liver P = 0.014 0.031 and 0.058 and matched pairs showed a higher prevalence of these risk factors in the samples with distant spread P = 0.029; Silencing of miR-34a and upregulation of c-Met Snail and β-catenin expression is associated with liver metastases of colon cancer; Detection of miR-34a silencing in resected primary colon cancer may be of prognostic value especially in combination with detection of c-Met and β-catenin expression;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004;c-Met is a target of miR-34a and regulates the migration and invasion of osteosarcoma cells; Osteosarcoma cells over-expressing miR-34a exhibited a significant decrease in the expression levels of c-Met mRNA and protein simultaneously; The results presented in this study demonstrated that over-expression of miR-34a could inhibit the tumor growth and metastasis of osteosarcoma probably through down regulating c-Met; And there are other putative miR-34a target genes beside c-Met which could potentially be key players in the development of osteosarcoma;Underexpression of miR 34a in hepatocellular carcinoma and its contribution towards enhancement of proliferating inhibitory effects of agents targeting c MET; In addition miR-34a mimic enhanced the effect of cell proliferation inhibition and caspase activity induction of agents targeting c-MET siRNAs and small molecular inhibitor su11274;miR 34a inhibits migration and invasion by down regulation of c Met expression in human hepatocellular carcinoma cells; miR-34a directly targeted c-Met and reduced both mRNA and protein levels of c-Met; thus decreased c-Met-induced phosphorylation of extracellular signal-regulated kinases 1 and 2 ERK1/2; Taken together these results provide evidence to show the suppression role of miR-34a in tumor migration and invasion through modulation of the c-Met signaling pathway;miR-34a levels in human gliomas inversely correlated to c-Met levels measured in the same tumors; Forced expression of c-Met or Notch-1/Notch-2 transcripts lacking the 3'-untranslated region sequences partially reversed the effects of miR-34a on cell cycle arrest and cell death in glioma cells and stem cells respectively; They show that miR-34a suppresses brain tumor growth by targeting c-Met and Notch;MicroRNA 34a inhibits uveal melanoma cell proliferation and migration through downregulation of c Met; In addition expression of c-Met and cell cycle-related proteins was determined by Western blotting and immunofluorescence after the introduction of miR-34a miR-34a is actively expressed in melanocytes but not in uveal melanoma cells based on Northern blot analysis; After identification of two putative miR-34a binding sites within the 3' UTR of the human c-Met mRNA miR-34a was shown to suppress luciferase activity using HEK293 cells with a luciferase reporter construct containing the binding sites; miR-34a was confirmed to downregulate the expression of c-Met protein by Western blotting and immunofluorescence; These results demonstrate that miR-34a acts as a tumor suppressor in uveal melanoma cell proliferation and migration through the downregulation of c-Met metastasis;;metastasis;;;; colon cancer;lung cancer;sarcoma;liver cancer;liver cancer;glioblastoma;melanoma hsa-miR-362-3p MET -0.697212068252854 2.61718493418184e-06 1.10982494733612 1.35440527522278e-11 miRanda -0.143259339177905 0.00348019977924639 NA NA NA hsa-miR-374a-5p MET -0.621903385111545 6.61791773205282e-12 1.10982494733612 1.35440527522278e-11 mirMAP -0.289612089463004 0.000275595796848531 NA NA NA hsa-miR-374b-5p MET -0.288413933608091 0.0041474558664058 1.10982494733612 1.35440527522278e-11 mirMAP -0.288822027493138 7.17864715731861e-05 NA NA NA hsa-miR-664a-3p MET -0.256108763664991 0.0513188660751664 1.10982494733612 1.35440527522278e-11 mirMAP -0.215038037480857 0.000107858694717852 NA NA NA hsa-miR-29b-2-5p MTOR -0.502720326849742 0.000730448246894952 -0.0410123345203521 0.614695102067527 MirTarget -0.103017109775977 1.24283506305444e-05 NA NA NA hsa-miR-30d-3p MTOR -0.577371911152798 2.02950840095287e-06 -0.0410123345203521 0.614695102067527 MirTarget -0.124450067301075 1.61925552977468e-05 NA NA NA hsa-miR-96-5p MTOR 1.42326703011157 4.39736150032373e-14 -0.0410123345203521 0.614695102067527 MirTarget;TargetScan;miRNATAP -0.115731720644867 1.22282664743637e-10 25333253 We report here hypoxia increased the expression of miR-96 in prostate cancer cells and miR-96 stimulated autophagy by suppressing MTOR; These data demonstrate hypoxia-induced autophagy is at least partially regulated by miR-96; miR-96 can promote or inhibit autophagy by principally inhibiting MTOR or ATG7 depending on the expression levels of miR-96 prostate cancer hsa-miR-127-3p MYB -1.47175957435172 9.8707469067377e-14 -0.928190773944983 0.00182497899993375 miRanda -0.182500209651974 0.0044950268850756 NA NA NA hsa-miR-193a-3p MYB 0.22120710726779 0.111827069464729 -0.928190773944983 0.00182497899993375 miRanda -0.601744891672982 7.42440064138269e-11 NA NA NA hsa-miR-193b-3p MYB 1.72788400801602 3.0722151264559e-21 -0.928190773944983 0.00182497899993375 miRNAWalker2_validate -0.837877234987241 6.55910178305708e-40 NA NA NA hsa-miR-206 MYB -2.75569967746838 5.1299828721187e-05 -0.928190773944983 0.00182497899993375 miRanda -0.11111513545816 2.99864450658873e-09 NA NA NA hsa-miR-424-5p MYB 1.48125289532143 9.10372985713165e-19 -0.928190773944983 0.00182497899993375 miRNAWalker2_validate;miRTarBase;miRNATAP -0.547252173806217 9.41591891278306e-14 24675898 MicroRNA 424 is down regulated in hepatocellular carcinoma and suppresses cell migration and invasion through c Myb; In addition we further identified c-Myb as a functional downstream target of miR-424 by directly targeting the 3'UTR of c-Myb; Our results demonstrated that miR-424 was involved in tumorigenesis of HCC at least in part by suppression of c-Myb cell migration;tumorigenesis liver cancer hsa-miR-455-5p MYB 1.408595672323 5.52039116456697e-22 -0.928190773944983 0.00182497899993375 miRanda -0.830302431260387 3.68731941757979e-24 NA NA NA hsa-miR-542-3p MYB 0.643308814904977 8.81635403230104e-07 -0.928190773944983 0.00182497899993375 miRanda -0.503458387835945 2.83680000934475e-07 NA NA NA hsa-let-7c-5p MYC -2.07953368242668 3.46048888391218e-23 -0.32772106147221 0.0189770115533449 miRNAWalker2_validate;miRTarBase -0.107421906050131 0.000103545158346461 22128178 MicroRNA let 7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells prostate cancer hsa-miR-34a-5p MYC -0.117372471043915 0.364001947180738 -0.32772106147221 0.0189770115533449 miRNAWalker2_validate;miRTarBase -0.157674637324898 0.000854501792660625 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-15a-5p NFKB1 0.783550182002274 2.60699595655907e-11 -0.0586166405595643 0.532939439102198 miRNAWalker2_validate -0.100524054629175 0.00332260332322556 NA NA NA hsa-let-7c-5p NGF -2.07953368242668 3.46048888391218e-23 1.08938604562817 0.00258107261776762 MirTarget -0.474331709252181 2.09923806999807e-11 NA NA NA hsa-let-7d-5p NGF 0.481757661442508 3.66030810124939e-07 1.08938604562817 0.00258107261776762 MirTarget -0.66981065797809 5.57819243832775e-05 NA NA NA hsa-let-7g-5p NGF -0.250780249469264 0.00939610188330072 1.08938604562817 0.00258107261776762 MirTarget -1.0538459376691 8.8206138464407e-11 NA NA NA hsa-miR-320a NGF 0.801356001806321 4.91397101474502e-09 1.08938604562817 0.00258107261776762 miRanda -0.394376196453096 0.000532905541066623 NA NA NA hsa-miR-320b NGF 1.23473838180754 3.04337566045537e-14 1.08938604562817 0.00258107261776762 miRanda -0.4625048476379 9.04690456635774e-07 NA NA NA hsa-miR-423-5p NGF 0.60141781325829 1.62940950644999e-07 1.08938604562817 0.00258107261776762 MirTarget;miRNATAP -0.412248193811393 0.00259074860264355 NA NA NA hsa-miR-429 NGF 0.559451508722375 0.00563641638673083 1.08938604562817 0.00258107261776762 miRanda -0.479244868905427 4.56216629494526e-10 NA NA NA hsa-miR-429 NOS3 0.559451508722375 0.00563641638673083 0.298346303074626 0.0796702739110418 miRanda -0.149004334883291 4.36466168709426e-05 NA NA NA hsa-miR-324-5p NR4A1 1.66709479707179 1.45961450445769e-23 -1.47482767400841 6.55750227177689e-10 miRanda -0.163367847815031 0.00718489179540941 NA NA NA hsa-miR-145-5p NRAS -0.46917511594055 0.000685297625493134 0.398384760345124 2.73206950817875e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.127512559718541 2.02648627117484e-05 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-195-3p NRAS -0.624259620429699 0.000164279659144497 0.398384760345124 2.73206950817875e-05 mirMAP -0.105599176842807 2.41335123569666e-05 NA NA NA hsa-miR-26b-5p NRAS -0.254478038884324 0.0285227763044636 0.398384760345124 2.73206950817875e-05 mirMAP;miRNATAP -0.118342937472199 0.000985220833353607 NA NA NA hsa-miR-29b-3p NRAS -0.110721443686039 0.511264554091106 0.398384760345124 2.73206950817875e-05 miRNATAP -0.115340209430372 2.64204854445589e-06 NA NA NA hsa-miR-30e-3p NRAS -0.890635378639789 1.65740480611339e-16 0.398384760345124 2.73206950817875e-05 mirMAP -0.108551838334895 0.00387728250241298 NA NA NA hsa-miR-374a-3p NRAS -0.299190081500425 0.00682975596757891 0.398384760345124 2.73206950817875e-05 miRNATAP -0.154068780755208 4.21664914129326e-05 NA NA NA hsa-miR-374a-5p NRAS -0.621903385111545 6.61791773205282e-12 0.398384760345124 2.73206950817875e-05 mirMAP -0.130523090756999 0.00410722859636246 NA NA NA hsa-miR-374b-5p NRAS -0.288413933608091 0.0041474558664058 0.398384760345124 2.73206950817875e-05 mirMAP -0.269889320734344 4.1936925860835e-11 NA NA NA hsa-miR-664a-3p NRAS -0.256108763664991 0.0513188660751664 0.398384760345124 2.73206950817875e-05 MirTarget -0.25886236854543 4.55022879480367e-17 NA NA NA hsa-miR-142-3p NTF3 1.12754191614028 1.68798138028946e-08 -2.59170390715855 6.01062258777627e-15 miRanda -0.322747576045281 9.89154762280905e-06 NA NA NA hsa-miR-21-5p NTF3 1.62465922021121 3.44191300985109e-58 -2.59170390715855 6.01062258777627e-15 miRTarBase;miRNATAP -0.943998281374355 2.75568921736203e-13 NA NA NA hsa-miR-221-3p NTF3 0.410625614724387 0.000741090075261272 -2.59170390715855 6.01062258777627e-15 miRNATAP -0.452111562225564 0.000213183149722111 NA NA NA hsa-miR-222-3p NTF3 1.08197052578759 2.32604040301699e-14 -2.59170390715855 6.01062258777627e-15 miRNATAP -0.597619929003425 3.57843462941801e-09 NA NA NA hsa-miR-590-3p NTF3 0.221436901462551 0.0965904764063157 -2.59170390715855 6.01062258777627e-15 miRanda -0.321635739216939 0.00411542175857866 NA NA NA hsa-miR-590-5p NTF3 0.763025362395968 3.65305892505623e-09 -2.59170390715855 6.01062258777627e-15 PITA;miRanda;miRNATAP -0.359406854483493 0.0015720105948893 NA NA NA hsa-miR-125a-3p NTRK2 0.116035800853173 0.444825559956959 -1.11513528054371 0.0139689274900379 miRanda -0.441990373389826 0.000718256641505087 NA NA NA hsa-miR-142-3p NTRK2 1.12754191614028 1.68798138028946e-08 -1.11513528054371 0.0139689274900379 miRanda -0.287360686025783 0.00327565677298023 NA NA NA hsa-miR-142-5p NTRK2 0.288897753038094 0.0900009317815725 -1.11513528054371 0.0139689274900379 mirMAP -0.325271731506136 0.005197294312762 NA NA NA hsa-miR-146b-5p NTRK2 0.917975986853978 3.33749259316025e-09 -1.11513528054371 0.0139689274900379 PITA;miRanda -0.608432796014462 1.1319364914014e-06 NA NA NA hsa-miR-155-5p NTRK2 0.533437622040649 0.00248671179205372 -1.11513528054371 0.0139689274900379 mirMAP -0.290455272050116 0.00960861019429555 NA NA NA hsa-miR-181a-5p NTRK2 0.819060835827404 1.38616688310277e-13 -1.11513528054371 0.0139689274900379 mirMAP -0.631050089356719 0.000320478592136622 NA NA NA hsa-miR-181b-5p NTRK2 0.974255518824355 2.64876280203475e-16 -1.11513528054371 0.0139689274900379 mirMAP -0.988904775119714 6.54840711161066e-10 NA NA NA hsa-miR-186-5p NTRK2 0.353452958261612 0.000145058448579496 -1.11513528054371 0.0139689274900379 mirMAP -1.12885798594687 1.03540888238188e-07 NA NA NA hsa-miR-20a-3p NTRK2 1.34885093664027 2.07697464119202e-12 -1.11513528054371 0.0139689274900379 mirMAP -0.33556158712966 0.000877491532664743 NA NA NA hsa-miR-21-5p NTRK2 1.62465922021121 3.44191300985109e-58 -1.11513528054371 0.0139689274900379 mirMAP -0.5370106860942 0.00223232244493603 NA NA NA hsa-miR-22-3p NTRK2 0.00776313533473072 0.926356548861307 -1.11513528054371 0.0139689274900379 miRNATAP -0.764914528907096 0.00140748708480897 27662840 NTRK2 is an oncogene and associated with microRNA 22 regulation in human gastric cancer cell lines; The upstream regulator of NTRK2 microRNA-22 miR-22 was evaluated by dual-luciferase assay; In miR-22-upregulated MKN-28 and SNU-719 cells NTRK2 was further overexpressed to evaluate functional interaction between miR-22 and NTRK2 in GC; MiR-22 was verified to be an inverse upstream regulator of NTRK2; NTRK2 is an oncogene and reversely associated with miR-22 in regulating in vitro cancer development in GC gastric cancer hsa-miR-299-5p NTRK2 -1.92445654064493 1.52402531359074e-16 -1.11513528054371 0.0139689274900379 PITA -0.280431233884042 0.000676602024362476 NA NA NA hsa-miR-29a-5p NTRK2 0.323252792625584 0.0370417231222825 -1.11513528054371 0.0139689274900379 mirMAP -0.622411811466971 9.52438364565386e-07 NA NA NA hsa-miR-301a-3p NTRK2 2.14132004241926 4.46255413526808e-25 -1.11513528054371 0.0139689274900379 mirMAP -0.41370094338822 4.90974280092853e-06 NA NA NA hsa-miR-330-5p NTRK2 0.944693925383906 5.04972895657346e-13 -1.11513528054371 0.0139689274900379 miRanda -0.737054805452755 5.71327871260934e-07 NA NA NA hsa-miR-338-3p NTRK2 -0.948755228846395 8.99167125682392e-08 -1.11513528054371 0.0139689274900379 miRanda -0.533792504538669 1.09591550522627e-06 NA NA NA hsa-miR-339-5p NTRK2 1.07771430326938 2.45772601859307e-09 -1.11513528054371 0.0139689274900379 miRanda -0.278714184510507 0.00991541876007542 NA NA NA hsa-miR-342-3p NTRK2 0.99756868977753 9.28499866272332e-10 -1.11513528054371 0.0139689274900379 miRanda -0.532338738427602 7.79883630091174e-06 NA NA NA hsa-miR-452-3p NTRK2 1.09618110917892 2.21867884261816e-07 -1.11513528054371 0.0139689274900379 mirMAP -0.260313701493982 0.00489780827399834 NA NA NA hsa-miR-454-3p NTRK2 1.54137391927201 4.15861570449376e-20 -1.11513528054371 0.0139689274900379 mirMAP -0.504437015123473 8.16691472054223e-06 NA NA NA hsa-miR-455-3p NTRK2 2.68574446868387 4.28975903022818e-42 -1.11513528054371 0.0139689274900379 mirMAP -0.525066893090797 8.16274777713328e-09 NA NA NA hsa-miR-501-5p NTRK2 1.02806906860218 1.63456814370548e-09 -1.11513528054371 0.0139689274900379 mirMAP -0.378256345060406 0.00110146255037686 NA NA NA hsa-miR-576-5p NTRK2 0.940432050128373 6.90227595663302e-12 -1.11513528054371 0.0139689274900379 PITA;mirMAP -1.01793683008079 2.36682358426359e-13 NA NA NA hsa-miR-590-3p NTRK2 0.221436901462551 0.0965904764063157 -1.11513528054371 0.0139689274900379 PITA;miRanda;mirMAP -0.390843032150866 0.00886155311856371 NA NA NA hsa-miR-139-5p OSMR -1.46099200329485 7.85040381494472e-22 0.439137012220466 0.0175237971977372 miRanda -0.136006703230251 0.00760082728029919 NA NA NA hsa-miR-200b-3p OSMR 0.0717138787925347 0.682858087587209 0.439137012220466 0.0175237971977372 TargetScan -0.196859758190871 1.73370356000614e-05 NA NA NA hsa-miR-335-5p OSMR -1.17227779671552 1.49282618530733e-10 0.439137012220466 0.0175237971977372 miRNAWalker2_validate -0.13269130640974 0.0021678691879024 NA NA NA hsa-miR-362-3p OSMR -0.697212068252854 2.61718493418184e-06 0.439137012220466 0.0175237971977372 miRanda -0.211575946960926 8.99717303090219e-05 NA NA NA hsa-miR-374a-5p OSMR -0.621903385111545 6.61791773205282e-12 0.439137012220466 0.0175237971977372 mirMAP -0.297593268699733 0.000730239600726995 NA NA NA hsa-miR-374b-5p OSMR -0.288413933608091 0.0041474558664058 0.439137012220466 0.0175237971977372 mirMAP -0.384562031028341 1.59752732401194e-06 NA NA NA hsa-miR-429 OSMR 0.559451508722375 0.00563641638673083 0.439137012220466 0.0175237971977372 miRanda;miRNATAP -0.193727874388202 9.39401488930102e-07 NA NA NA hsa-miR-495-3p OSMR -1.47803501311999 6.88839745293927e-13 0.439137012220466 0.0175237971977372 mirMAP -0.110934217419729 0.00385889172384574 NA NA NA hsa-miR-26b-5p PDGFB -0.254478038884324 0.0285227763044636 0.845464958577077 8.67485169100214e-08 miRNAWalker2_validate -0.172324630804419 0.00423712529201602 NA NA NA hsa-miR-29b-2-5p PDGFB -0.502720326849742 0.000730448246894952 0.845464958577077 8.67485169100214e-08 mirMAP -0.266903581406135 7.38754988734083e-09 NA NA NA hsa-miR-29b-3p PDGFB -0.110721443686039 0.511264554091106 0.845464958577077 8.67485169100214e-08 MirTarget;miRNATAP -0.160863843240162 9.73115177806472e-05 NA NA NA hsa-miR-29c-3p PDGFB -2.08166260448948 8.3238369390898e-24 0.845464958577077 8.67485169100214e-08 MirTarget;miRNATAP -0.164724591746529 2.30913539327549e-07 NA NA NA hsa-miR-342-3p PDGFB 0.99756868977753 9.28499866272332e-10 0.845464958577077 8.67485169100214e-08 miRanda -0.177362693333945 2.31239920349643e-05 NA NA NA hsa-miR-142-5p PDGFC 0.288897753038094 0.0900009317815725 -0.00261703252197343 0.990199267236464 PITA -0.18457759676812 0.000688250372045889 NA NA NA hsa-miR-16-2-3p PDGFC 1.1567130855258 1.01867256952189e-14 -0.00261703252197343 0.990199267236464 mirMAP -0.474176996283446 8.26018149592353e-16 NA NA NA hsa-miR-205-3p PDGFC 1.2960640797621 5.80786479909147e-11 -0.00261703252197343 0.990199267236464 mirMAP -0.27101775517427 2.31136634094134e-09 NA NA NA hsa-miR-335-3p PDGFC 0.336785882180547 0.0542446207938138 -0.00261703252197343 0.990199267236464 mirMAP -0.230464396095882 1.24238770167534e-05 NA NA NA hsa-miR-3607-3p PDGFC 1.01377165357363 9.13355519701165e-05 -0.00261703252197343 0.990199267236464 mirMAP -0.186371529607517 1.21414800298297e-07 NA NA NA hsa-miR-361-5p PDGFC 0.0803683277369505 0.314043140368058 -0.00261703252197343 0.990199267236464 miRanda -0.319526055516819 0.00691691231730144 NA NA NA hsa-miR-374a-3p PDGFC -0.299190081500425 0.00682975596757891 -0.00261703252197343 0.990199267236464 mirMAP -0.245258524939923 0.00359679502310855 NA NA NA hsa-miR-582-3p PDGFC -0.248056267546012 0.143798829508405 -0.00261703252197343 0.990199267236464 PITA -0.254113689314753 2.94427514642266e-06 NA NA NA hsa-miR-590-3p PDGFC 0.221436901462551 0.0965904764063157 -0.00261703252197343 0.990199267236464 PITA;miRanda;mirMAP -0.212685095241742 0.00231382570189075 NA NA NA hsa-miR-7-1-3p PDGFC 1.13646121619622 1.49823237535933e-14 -0.00261703252197343 0.990199267236464 mirMAP -0.382435034916375 2.25465436289282e-10 NA NA NA hsa-miR-19b-1-5p PDGFD 0.757034032029085 2.99828133413343e-07 -1.46202391708138 4.2355844030761e-11 MirTarget -0.511985051973844 1.82114576561545e-15 NA NA NA hsa-miR-203a-3p PDGFD 0.0441399794719697 0.880456392176704 -1.46202391708138 4.2355844030761e-11 MirTarget -0.231723998876994 1.82675481111625e-12 NA NA NA hsa-miR-21-5p PDGFD 1.62465922021121 3.44191300985109e-58 -1.46202391708138 4.2355844030761e-11 miRNAWalker2_validate -0.589602693801609 6.1971280888613e-12 NA NA NA hsa-miR-320a PDGFD 0.801356001806321 4.91397101474502e-09 -1.46202391708138 4.2355844030761e-11 miRanda -0.246731728430742 0.000505172675992749 NA NA NA hsa-miR-331-5p PDGFD 0.851618030062133 1.42670149420057e-14 -1.46202391708138 4.2355844030761e-11 MirTarget -0.585766842115598 7.9439593514765e-12 NA NA NA hsa-miR-450b-5p PDGFD 1.25529820885833 1.18847120528666e-15 -1.46202391708138 4.2355844030761e-11 mirMAP -0.171978679422097 0.00490540772794391 NA NA NA hsa-miR-590-3p PDGFD 0.221436901462551 0.0965904764063157 -1.46202391708138 4.2355844030761e-11 miRanda;mirMAP;miRNATAP -0.336744458887879 4.96058821646432e-06 NA NA NA hsa-miR-590-5p PDGFD 0.763025362395968 3.65305892505623e-09 -1.46202391708138 4.2355844030761e-11 miRanda -0.61987493834665 2.19312836316757e-17 NA NA NA hsa-miR-7-1-3p PDGFD 1.13646121619622 1.49823237535933e-14 -1.46202391708138 4.2355844030761e-11 mirMAP -0.457779796600521 6.64557064170379e-13 NA NA NA hsa-miR-944 PDGFD 1.47323925060177 2.61626403984929e-13 -1.46202391708138 4.2355844030761e-11 MirTarget;mirMAP -0.375455715589598 6.26282968164067e-16 NA NA NA hsa-let-7a-3p PDGFRA 0.0966652362351867 0.423761916840503 -0.463142743937045 0.04817832252781 mirMAP -0.529669602176716 2.68390850522982e-10 NA NA NA hsa-let-7f-1-3p PDGFRA 0.700374242293247 8.65000484720084e-08 -0.463142743937045 0.04817832252781 mirMAP -0.203048287649371 0.00882303668338635 NA NA NA hsa-let-7g-3p PDGFRA 0.637019243992294 0.000204623048574065 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.242214636780195 4.14305980343687e-05 NA NA NA hsa-miR-106a-5p PDGFRA 0.67978010057847 0.00221925869726092 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.187108191561856 4.125997505122e-05 NA NA NA hsa-miR-106b-5p PDGFRA 0.50378717276868 1.45412404526866e-05 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.279116396967218 0.00146889907846801 NA NA NA hsa-miR-130a-3p PDGFRA 0.67051191119964 4.89747518735144e-06 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.515723307874652 2.38971422139082e-14 NA NA NA hsa-miR-141-3p PDGFRA 0.730011517758706 0.000120338355004032 -0.463142743937045 0.04817832252781 MirTarget -0.505767490532425 6.91381154503213e-23 NA NA NA hsa-miR-149-5p PDGFRA 0.443278770827687 0.0642022866136881 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.173776938709491 4.23057230524602e-05 NA NA NA hsa-miR-16-1-3p PDGFRA 0.955017760172879 5.95379292601146e-11 -0.463142743937045 0.04817832252781 MirTarget -0.394960139372927 7.06855621054673e-09 NA NA NA hsa-miR-17-5p PDGFRA 1.41924888736771 2.75805544953758e-18 -0.463142743937045 0.04817832252781 MirTarget;TargetScan;miRNATAP -0.486966289383704 1.65975367184753e-16 NA NA NA hsa-miR-182-5p PDGFRA 1.15060905311096 6.25565852529946e-10 -0.463142743937045 0.04817832252781 miRNATAP -0.251226400702905 2.8736296191221e-06 NA NA NA hsa-miR-186-5p PDGFRA 0.353452958261612 0.000145058448579496 -0.463142743937045 0.04817832252781 MirTarget -0.430638628510272 9.25678657223338e-05 NA NA NA hsa-miR-193a-3p PDGFRA 0.22120710726779 0.111827069464729 -0.463142743937045 0.04817832252781 miRanda -0.385360637474971 1.31801900899795e-07 NA NA NA hsa-miR-196b-5p PDGFRA 3.78958266598891 1.12771732893771e-44 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.141611620840498 3.83240889487933e-05 NA NA NA hsa-miR-200a-3p PDGFRA 0.607140814457753 0.00289840524858752 -0.463142743937045 0.04817832252781 MirTarget -0.418556109432712 5.5401611171402e-18 NA NA NA hsa-miR-20a-5p PDGFRA 1.1531986665452 1.02385132917958e-11 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.459634108198747 1.4648906334426e-15 NA NA NA hsa-miR-224-5p PDGFRA 1.94534596857416 1.88348779207332e-19 -0.463142743937045 0.04817832252781 MirTarget -0.291603637702123 8.45665637241549e-11 NA NA NA hsa-miR-26b-5p PDGFRA -0.254478038884324 0.0285227763044636 -0.463142743937045 0.04817832252781 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.29571434460346 0.000811001382839524 NA NA NA hsa-miR-27a-3p PDGFRA 0.348456440505425 0.00126682892514312 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.399431408470765 2.36940280836809e-05 NA NA NA hsa-miR-29b-1-5p PDGFRA 1.39669186711325 4.36960953138935e-11 -0.463142743937045 0.04817832252781 mirMAP -0.310505328638843 2.6214579770892e-11 NA NA NA hsa-miR-29b-3p PDGFRA -0.110721443686039 0.511264554091106 -0.463142743937045 0.04817832252781 MirTarget -0.309199593590445 2.87491088364754e-07 NA NA NA hsa-miR-301a-3p PDGFRA 2.14132004241926 4.46255413526808e-25 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.30716680230266 2.9839566707638e-11 NA NA NA hsa-miR-320a PDGFRA 0.801356001806321 4.91397101474502e-09 -0.463142743937045 0.04817832252781 miRanda -0.256088551213152 0.000504831123583266 NA NA NA hsa-miR-320b PDGFRA 1.23473838180754 3.04337566045537e-14 -0.463142743937045 0.04817832252781 miRanda -0.236668681167249 0.000109090155715803 NA NA NA hsa-miR-330-5p PDGFRA 0.944693925383906 5.04972895657346e-13 -0.463142743937045 0.04817832252781 miRanda -0.214351710717381 0.00518115566688398 NA NA NA hsa-miR-338-3p PDGFRA -0.948755228846395 8.99167125682392e-08 -0.463142743937045 0.04817832252781 miRanda -0.159079633123343 0.00521295319497949 NA NA NA hsa-miR-339-5p PDGFRA 1.07771430326938 2.45772601859307e-09 -0.463142743937045 0.04817832252781 miRanda -0.412211810143285 3.68470566893721e-14 NA NA NA hsa-miR-33a-5p PDGFRA 1.12988965056352 3.35742517382153e-07 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.295170225755906 4.71759962730372e-11 NA NA NA hsa-miR-33b-5p PDGFRA 0.681845193600723 0.00407790722487864 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.237387453331384 5.90803903406106e-08 NA NA NA hsa-miR-342-3p PDGFRA 0.99756868977753 9.28499866272332e-10 -0.463142743937045 0.04817832252781 MirTarget;miRanda;miRNATAP -0.201117464069554 0.0011186847998832 NA NA NA hsa-miR-34a-5p PDGFRA -0.117372471043915 0.364001947180738 -0.463142743937045 0.04817832252781 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.279473416683797 0.000425575449508612 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-429 PDGFRA 0.559451508722375 0.00563641638673083 -0.463142743937045 0.04817832252781 miRanda;miRNATAP -0.3646603274658 1.47498623679927e-13 NA NA NA hsa-miR-454-3p PDGFRA 1.54137391927201 4.15861570449376e-20 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.406092239175468 1.67299803475594e-12 NA NA NA hsa-miR-455-5p PDGFRA 1.408595672323 5.52039116456697e-22 -0.463142743937045 0.04817832252781 MirTarget;PITA;miRanda -0.261429891373877 9.49351636713376e-05 NA NA NA hsa-miR-576-5p PDGFRA 0.940432050128373 6.90227595663302e-12 -0.463142743937045 0.04817832252781 mirMAP -0.48252244916662 2.04399434436523e-11 NA NA NA hsa-miR-589-3p PDGFRA 1.59559692667315 6.2886410639161e-15 -0.463142743937045 0.04817832252781 mirMAP -0.333031429734795 2.20227456353819e-11 NA NA NA hsa-miR-590-3p PDGFRA 0.221436901462551 0.0965904764063157 -0.463142743937045 0.04817832252781 miRanda;mirMAP -0.363428459817233 2.01021651672196e-06 NA NA NA hsa-miR-590-5p PDGFRA 0.763025362395968 3.65305892505623e-09 -0.463142743937045 0.04817832252781 miRanda -0.630471151401988 1.02894688811306e-16 NA NA NA hsa-miR-7-1-3p PDGFRA 1.13646121619622 1.49823237535933e-14 -0.463142743937045 0.04817832252781 mirMAP -0.470693839225208 1.10880684128766e-12 NA NA NA hsa-miR-93-5p PDGFRA 1.61042951896619 5.1280369606967e-24 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.345803927630158 1.16570780178394e-08 NA NA NA hsa-miR-944 PDGFRA 1.47323925060177 2.61626403984929e-13 -0.463142743937045 0.04817832252781 mirMAP -0.182467322614544 0.000220849656173125 NA NA NA hsa-miR-96-5p PDGFRA 1.42326703011157 4.39736150032373e-14 -0.463142743937045 0.04817832252781 TargetScan;miRNATAP -0.373700371207876 5.21978290236253e-13 NA NA NA hsa-miR-29a-3p PDGFRB -1.26881270980079 2.82496991513463e-22 1.61349776863339 3.00832890375111e-14 miRNATAP -0.252848924108258 0.0002864380072827 NA NA NA hsa-miR-29b-3p PDGFRB -0.110721443686039 0.511264554091106 1.61349776863339 3.00832890375111e-14 miRNATAP -0.381814573387718 5.66152644629818e-12 NA NA NA hsa-miR-29c-3p PDGFRB -2.08166260448948 8.3238369390898e-24 1.61349776863339 3.00832890375111e-14 miRNATAP -0.230825030507139 1.04275605654934e-07 NA NA NA hsa-miR-338-3p PDGFRB -0.948755228846395 8.99167125682392e-08 1.61349776863339 3.00832890375111e-14 miRanda -0.2824081657779 6.98566776548666e-08 NA NA NA hsa-miR-34a-5p PDGFRB -0.117372471043915 0.364001947180738 1.61349776863339 3.00832890375111e-14 MirTarget -0.416833898128444 1.12557808434585e-08 24837198 MicroRNA 34A inhibits the growth invasion and metastasis of gastric cancer by targeting PDGFR and MET expression; In this study our aim was to identify the miRNAs that target PDGFR-α/β and to study the functions of these miRNAs miR-34a was predicted to target PDGFR and luciferase reporter assays showed that miR-34a could directly target PDGFR; Moreover the cancer-associated cell signalling pathway was studied and we found that miR-34a could inhibit Akt PKB protein kinase B phosphorylation which was restored by the overexpression of both PDGFR and MET; In conclusion miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K phosphoinositide 3-kinase/Akt pathway metastasis gastric cancer hsa-miR-361-3p PDGFRB 0.272298288982435 0.0147874880476998 1.61349776863339 3.00832890375111e-14 MirTarget -0.245649935526185 0.00405851316554908 NA NA NA hsa-miR-664a-3p PDGFRB -0.256108763664991 0.0513188660751664 1.61349776863339 3.00832890375111e-14 MirTarget -0.201316703730783 0.00552266661901063 NA NA NA hsa-miR-9-5p PDGFRB 1.65694862043766 2.08325802567323e-05 1.61349776863339 3.00832890375111e-14 MirTarget;miRNATAP -0.101903933904259 2.25485460574598e-05 NA NA NA hsa-miR-103a-3p PDPK1 0.556219385347418 1.55815736455067e-09 -0.374841923318686 0.000672007355166274 mirMAP -0.29017497623463 1.7103988105315e-08 NA NA NA hsa-miR-125a-5p PDPK1 0.215366061934933 0.119550904549401 -0.374841923318686 0.000672007355166274 miRNAWalker2_validate;mirMAP -0.20458547523825 2.96393173254167e-09 NA NA NA hsa-miR-130b-5p PDPK1 1.77265255049999 1.43627774829684e-29 -0.374841923318686 0.000672007355166274 mirMAP -0.118592255898703 3.97903467320827e-05 NA NA NA hsa-miR-148b-5p PDPK1 1.1533193737265 7.26420964688337e-13 -0.374841923318686 0.000672007355166274 mirMAP -0.159957807676691 5.21685211952077e-08 NA NA NA hsa-miR-15a-5p PDPK1 0.783550182002274 2.60699595655907e-11 -0.374841923318686 0.000672007355166274 mirMAP -0.310907696179115 2.89097442842771e-15 NA NA NA hsa-miR-17-5p PDPK1 1.41924888736771 2.75805544953758e-18 -0.374841923318686 0.000672007355166274 miRNAWalker2_validate;mirMAP -0.188610500072922 2.00392592187993e-11 NA NA NA hsa-miR-186-5p PDPK1 0.353452958261612 0.000145058448579496 -0.374841923318686 0.000672007355166274 mirMAP -0.227196548230479 1.15125913292726e-05 NA NA NA hsa-miR-197-3p PDPK1 0.878693269130833 3.84847526014135e-15 -0.374841923318686 0.000672007355166274 mirMAP -0.143504954220919 0.000651631392166555 NA NA NA hsa-miR-20a-5p PDPK1 1.1531986665452 1.02385132917958e-11 -0.374841923318686 0.000672007355166274 mirMAP -0.196318407478492 6.24384965065394e-13 NA NA NA hsa-miR-22-5p PDPK1 0.706731861922839 3.44318705980007e-07 -0.374841923318686 0.000672007355166274 miRNATAP -0.195090596012909 1.0156148239318e-08 NA NA NA hsa-miR-2355-5p PDPK1 1.47205546931107 8.65192179636668e-19 -0.374841923318686 0.000672007355166274 mirMAP -0.141891966150004 3.11854262455652e-07 NA NA NA hsa-miR-29b-3p PDPK1 -0.110721443686039 0.511264554091106 -0.374841923318686 0.000672007355166274 mirMAP -0.153513947978287 6.08833428400365e-08 NA NA NA hsa-miR-320a PDPK1 0.801356001806321 4.91397101474502e-09 -0.374841923318686 0.000672007355166274 miRanda -0.182840502373476 1.08171028199283e-07 NA NA NA hsa-miR-338-3p PDPK1 -0.948755228846395 8.99167125682392e-08 -0.374841923318686 0.000672007355166274 mirMAP -0.129012328728478 1.2622962488162e-06 NA NA NA hsa-miR-342-3p PDPK1 0.99756868977753 9.28499866272332e-10 -0.374841923318686 0.000672007355166274 mirMAP -0.183826709476054 1.400623732691e-10 NA NA NA hsa-miR-374a-3p PDPK1 -0.299190081500425 0.00682975596757891 -0.374841923318686 0.000672007355166274 mirMAP -0.151744661636615 0.00051129283675243 NA NA NA hsa-miR-374b-5p PDPK1 -0.288413933608091 0.0041474558664058 -0.374841923318686 0.000672007355166274 miRNATAP -0.205234606123058 1.86947415786769e-05 NA NA NA hsa-miR-505-3p PDPK1 0.912823669571645 4.0549774967148e-13 -0.374841923318686 0.000672007355166274 mirMAP -0.201857415938712 5.57828239099272e-08 NA NA NA hsa-miR-542-3p PDPK1 0.643308814904977 8.81635403230104e-07 -0.374841923318686 0.000672007355166274 mirMAP -0.12781199559745 0.000462839050750517 NA NA NA hsa-miR-589-3p PDPK1 1.59559692667315 6.2886410639161e-15 -0.374841923318686 0.000672007355166274 mirMAP -0.128382873058573 5.41604824914142e-08 NA NA NA hsa-miR-590-5p PDPK1 0.763025362395968 3.65305892505623e-09 -0.374841923318686 0.000672007355166274 miRanda -0.162196982236768 9.45496024959358e-06 NA NA NA hsa-miR-708-3p PDPK1 1.32647174389322 4.87465491977979e-16 -0.374841923318686 0.000672007355166274 miRNATAP -0.14419428661467 3.79731361528411e-07 NA NA NA hsa-miR-93-3p PDPK1 1.69225547123293 1.50964095575087e-25 -0.374841923318686 0.000672007355166274 miRNATAP -0.114935719417259 4.60395655478685e-05 NA NA NA hsa-miR-93-5p PDPK1 1.61042951896619 5.1280369606967e-24 -0.374841923318686 0.000672007355166274 mirMAP -0.193660133494057 8.64542566364151e-12 NA NA NA hsa-miR-326 PGF -0.425943992128769 0.0415010315530797 1.7894778619937 1.67156328544061e-17 mirMAP -0.157120759961536 0.000531643956578871 NA NA NA hsa-miR-335-5p PGF -1.17227779671552 1.49282618530733e-10 1.7894778619937 1.67156328544061e-17 miRNATAP -0.285425943985743 1.33410478539352e-08 NA NA NA hsa-miR-34a-5p PGF -0.117372471043915 0.364001947180738 1.7894778619937 1.67156328544061e-17 miRNATAP -0.207393986339531 0.00483382962070574 NA NA NA hsa-miR-29b-1-5p PHLPP1 1.39669186711325 4.36960953138935e-11 -0.535936931776051 4.46725992473767e-06 MirTarget -0.145811069944723 4.83091074687687e-10 NA NA NA hsa-miR-589-5p PHLPP1 0.807877250867909 4.12262850391353e-14 -0.535936931776051 4.46725992473767e-06 MirTarget -0.126806814659827 0.00711872158278485 NA NA NA hsa-miR-19b-3p PHLPP2 0.538732279378089 0.000622008277870679 0.547833360760628 2.67718233419301e-07 mirMAP -0.119156432504051 5.56637040731178e-05 NA NA NA hsa-miR-27b-3p PHLPP2 -0.732682718863563 2.26896143573324e-09 0.547833360760628 2.67718233419301e-07 MirTarget;miRNATAP -0.165769629879923 1.04398198445206e-05 NA NA NA hsa-miR-139-5p PIK3AP1 -1.46099200329485 7.85040381494472e-22 0.10595580595967 0.651348908604332 miRanda -0.247746669887235 0.000115046687872818 NA NA NA hsa-miR-29a-5p PIK3AP1 0.323252792625584 0.0370417231222825 0.10595580595967 0.651348908604332 mirMAP -0.227985844982495 0.000530797782944209 NA NA NA hsa-miR-29b-1-5p PIK3AP1 1.39669186711325 4.36960953138935e-11 0.10595580595967 0.651348908604332 mirMAP -0.245186676192142 1.7009674348277e-07 NA NA NA hsa-miR-455-5p PIK3AP1 1.408595672323 5.52039116456697e-22 0.10595580595967 0.651348908604332 miRanda;miRNATAP -0.56100122581353 6.34047210270113e-18 NA NA NA hsa-miR-501-5p PIK3AP1 1.02806906860218 1.63456814370548e-09 0.10595580595967 0.651348908604332 miRNATAP -0.1778433896506 0.00292583734265649 NA NA NA hsa-miR-92a-3p PIK3AP1 0.994679542307232 1.32587679156217e-16 0.10595580595967 0.651348908604332 MirTarget -0.281184740699784 0.0006616106000207 NA NA NA hsa-miR-146b-5p PIK3CA 0.917975986853978 3.33749259316025e-09 0.474083948253385 0.000138354293457267 mirMAP -0.148623698754488 1.59224953432472e-05 NA NA NA hsa-miR-17-5p PIK3CA 1.41924888736771 2.75805544953758e-18 0.474083948253385 0.000138354293457267 miRNAWalker2_validate -0.121128691188414 0.000174670602072176 NA NA NA hsa-miR-186-5p PIK3CA 0.353452958261612 0.000145058448579496 0.474083948253385 0.000138354293457267 mirMAP -0.297473635549502 3.47602075640407e-07 NA NA NA hsa-miR-29b-1-5p PIK3CA 1.39669186711325 4.36960953138935e-11 0.474083948253385 0.000138354293457267 mirMAP -0.137606426566373 3.59722935161776e-08 NA NA NA hsa-miR-320a PIK3CA 0.801356001806321 4.91397101474502e-09 0.474083948253385 0.000138354293457267 miRanda -0.175899873415021 6.70887782534591e-06 NA NA NA hsa-miR-339-5p PIK3CA 1.07771430326938 2.45772601859307e-09 0.474083948253385 0.000138354293457267 miRanda -0.140087795917754 2.01352800438963e-06 NA NA NA hsa-miR-374b-5p PIK3CA -0.288413933608091 0.0041474558664058 0.474083948253385 0.000138354293457267 mirMAP -0.251699909641235 3.33151190183606e-06 NA NA NA hsa-miR-501-5p PIK3CA 1.02806906860218 1.63456814370548e-09 0.474083948253385 0.000138354293457267 mirMAP -0.119863788285527 0.00016396438241956 NA NA NA hsa-miR-576-5p PIK3CA 0.940432050128373 6.90227595663302e-12 0.474083948253385 0.000138354293457267 PITA -0.211172584428942 4.54724446596707e-08 NA NA NA hsa-miR-582-3p PIK3CA -0.248056267546012 0.143798829508405 0.474083948253385 0.000138354293457267 miRNATAP -0.112384075179319 0.000457171976884077 NA NA NA hsa-miR-590-3p PIK3CA 0.221436901462551 0.0965904764063157 0.474083948253385 0.000138354293457267 miRanda;mirMAP -0.123785866799948 0.00253231685417896 NA NA NA hsa-miR-590-5p PIK3CA 0.763025362395968 3.65305892505623e-09 0.474083948253385 0.000138354293457267 miRanda -0.137459565446424 0.000946581823458912 NA NA NA hsa-miR-130a-3p PIK3CB 0.67051191119964 4.89747518735144e-06 -0.0830016803916331 0.377605728994098 miRNATAP -0.116910694940516 2.17993945184649e-05 NA NA NA hsa-miR-455-5p PIK3CB 1.408595672323 5.52039116456697e-22 -0.0830016803916331 0.377605728994098 miRNATAP -0.112305249746916 2.65965267643942e-05 NA NA NA hsa-miR-1468-5p PIK3CD -1.11814152104975 9.8203170781489e-10 1.09936669850841 6.53933580961931e-14 MirTarget -0.190058878065479 5.39186071979921e-08 NA NA NA hsa-miR-199a-5p PIK3CD -0.364835768178638 0.0435119211101981 1.09936669850841 6.53933580961931e-14 MirTarget;PITA;miRanda;miRNATAP -0.10392905863127 0.00413232021656056 NA NA NA hsa-miR-199b-5p PIK3CD -1.08432682485992 7.68241801134089e-10 1.09936669850841 6.53933580961931e-14 MirTarget;PITA;miRanda;miRNATAP -0.174865940346935 1.46520648745166e-06 NA NA NA hsa-miR-29c-3p PIK3CD -2.08166260448948 8.3238369390898e-24 1.09936669850841 6.53933580961931e-14 mirMAP -0.123728555182124 3.91761687692399e-05 NA NA NA hsa-miR-30a-5p PIK3CD -1.79779915425811 1.93360169837799e-26 1.09936669850841 6.53933580961931e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.215181764255274 3.32715363881856e-09 23486085 miR 30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma; A luciferase reporter assay was performed to determine target association between miR-30a and phosphoinositide 3-kinase catalytic subunit delta PIK3CD miR-30a was significantly downregulated in highly metastatic CRC cell lines and metastatic tissues; Further studies revealed that PIK3CD is a direct target of miR-30a as miR-30a bounds directly to the 3'-UTR of PIK3CD subsequently reducing its expression; Similar to the restoring miR-30a expression PIK3CD downregulation inhibited cell migration and invasion whereas PIK3CD overexpression rescued the suppressive effect of miR-30a; Moreover significant downregulation of miR-30a in metastatic CRC tissues was found to be inversely correlated with PIK3CD expression; Mechanistic studies revealed that miR-30a down-regulated the expression of key components of the Akt/mTOR pathway whereas PIK3CD overexpression reversed this negative effect cell migration colorectal cancer hsa-miR-30b-3p PIK3CD -0.338530747940815 0.0223424741180399 1.09936669850841 6.53933580961931e-14 MirTarget -0.212653512510377 1.36776424072036e-06 NA NA NA hsa-miR-30b-5p PIK3CD -0.400238605368173 0.00346540992719245 1.09936669850841 6.53933580961931e-14 MirTarget -0.248889126985861 1.5426059915817e-07 NA NA NA hsa-miR-30d-5p PIK3CD -0.38399848121878 0.000171129616944749 1.09936669850841 6.53933580961931e-14 MirTarget;miRNATAP -0.328266173808776 2.63776877258142e-07 NA NA NA hsa-miR-30e-5p PIK3CD -1.02114836019762 6.81961221797866e-17 1.09936669850841 6.53933580961931e-14 MirTarget -0.209324939899388 5.5934958220938e-05 NA NA NA hsa-miR-126-3p PIK3CG 0.0487843863772834 0.730130847436008 0.00752271010659966 0.976960758681749 miRTarBase -0.269414114814437 0.000806379873030215 NA NA NA hsa-miR-26b-5p PIK3CG -0.254478038884324 0.0285227763044636 0.00752271010659966 0.976960758681749 miRNAWalker2_validate -0.345718989912845 0.00041292580999725 NA NA NA hsa-miR-335-3p PIK3CG 0.336785882180547 0.0542446207938138 0.00752271010659966 0.976960758681749 mirMAP -0.20863783184887 0.00127495716846541 NA NA NA hsa-miR-3607-3p PIK3CG 1.01377165357363 9.13355519701165e-05 0.00752271010659966 0.976960758681749 mirMAP -0.153979618634459 0.000387199003031277 NA NA NA hsa-miR-103a-3p PIK3R1 0.556219385347418 1.55815736455067e-09 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.399035342845615 3.61390305129075e-07 NA NA NA hsa-miR-1301-3p PIK3R1 2.13677668481885 6.11093268540831e-44 -1.21900359295309 1.01203266762174e-13 MirTarget -0.223004793710498 2.5912949051374e-07 NA NA NA hsa-miR-15a-5p PIK3R1 0.783550182002274 2.60699595655907e-11 -1.21900359295309 1.01203266762174e-13 MirTarget -0.385662977903284 1.7816116353762e-10 NA NA NA hsa-miR-15b-5p PIK3R1 0.85315666454713 3.79816274836297e-12 -1.21900359295309 1.01203266762174e-13 MirTarget -0.228618884263194 9.01523017331239e-05 NA NA NA hsa-miR-16-2-3p PIK3R1 1.1567130855258 1.01867256952189e-14 -1.21900359295309 1.01203266762174e-13 MirTarget -0.316425483424084 1.52783996282521e-11 NA NA NA hsa-miR-17-5p PIK3R1 1.41924888736771 2.75805544953758e-18 -1.21900359295309 1.01203266762174e-13 MirTarget;TargetScan;miRNATAP -0.463182517340129 2.13936557580788e-29 NA NA NA hsa-miR-182-5p PIK3R1 1.15060905311096 6.25565852529946e-10 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.244940881967473 1.25505363832818e-10 NA NA NA hsa-miR-185-5p PIK3R1 0.675225177054909 1.84953949190805e-13 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.284475955115523 0.000292942961891748 NA NA NA hsa-miR-186-5p PIK3R1 0.353452958261612 0.000145058448579496 -1.21900359295309 1.01203266762174e-13 mirMAP -0.319700116089251 4.98623038012755e-05 NA NA NA hsa-miR-188-5p PIK3R1 0.559328953885106 0.000430338888594543 -1.21900359295309 1.01203266762174e-13 MirTarget -0.160342440576419 0.000495444736297818 NA NA NA hsa-miR-200b-3p PIK3R1 0.0717138787925347 0.682858087587209 -1.21900359295309 1.01203266762174e-13 mirMAP -0.132316541375546 0.00152319590606084 NA NA NA hsa-miR-200c-3p PIK3R1 0.630251054099546 0.000131975031451555 -1.21900359295309 1.01203266762174e-13 mirMAP -0.165950070298812 0.000166005249225027 NA NA NA hsa-miR-20a-5p PIK3R1 1.1531986665452 1.02385132917958e-11 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.414035689070749 1.37700726304578e-24 NA NA NA hsa-miR-21-5p PIK3R1 1.62465922021121 3.44191300985109e-58 -1.21900359295309 1.01203266762174e-13 miRNAWalker2_validate;MirTarget;miRNATAP -0.347959293536401 6.14239978504788e-08 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 0.706731861922839 3.44318705980007e-07 -1.21900359295309 1.01203266762174e-13 mirMAP -0.186341013334501 0.000362689778770643 NA NA NA hsa-miR-222-3p PIK3R1 1.08197052578759 2.32604040301699e-14 -1.21900359295309 1.01203266762174e-13 MirTarget -0.324361920211689 6.16230355082933e-11 NA NA NA hsa-miR-224-3p PIK3R1 0.502645536188015 0.0081142387260641 -1.21900359295309 1.01203266762174e-13 mirMAP -0.120566945623901 0.00184832047796862 NA NA NA hsa-miR-29b-3p PIK3R1 -0.110721443686039 0.511264554091106 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.121645516169564 0.00518596779631768 NA NA NA hsa-miR-320a PIK3R1 0.801356001806321 4.91397101474502e-09 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.225199809648846 1.82460995490226e-05 NA NA NA hsa-miR-320b PIK3R1 1.23473838180754 3.04337566045537e-14 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.134920857869101 0.00211752860446172 NA NA NA hsa-miR-324-3p PIK3R1 0.867391246413545 3.63808540490361e-10 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRNATAP -0.177541714088148 0.000648957139596168 NA NA NA hsa-miR-424-5p PIK3R1 1.48125289532143 9.10372985713165e-19 -1.21900359295309 1.01203266762174e-13 MirTarget -0.194732317900543 3.45343462326547e-06 NA NA NA hsa-miR-429 PIK3R1 0.559451508722375 0.00563641638673083 -1.21900359295309 1.01203266762174e-13 mirMAP;miRNATAP -0.216477715044302 1.22729945836841e-09 NA NA NA hsa-miR-450b-5p PIK3R1 1.25529820885833 1.18847120528666e-15 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.182288230735551 5.59609717066614e-05 NA NA NA hsa-miR-455-3p PIK3R1 2.68574446868387 4.28975903022818e-42 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRNATAP -0.231037194203872 4.67534308068801e-12 NA NA NA hsa-miR-584-5p PIK3R1 0.458655788667031 0.0421764547676754 -1.21900359295309 1.01203266762174e-13 mirMAP -0.158511510137748 8.00515680759562e-07 NA NA NA hsa-miR-589-3p PIK3R1 1.59559692667315 6.2886410639161e-15 -1.21900359295309 1.01203266762174e-13 mirMAP -0.276889190811914 4.76785574986701e-15 NA NA NA hsa-miR-590-3p PIK3R1 0.221436901462551 0.0965904764063157 -1.21900359295309 1.01203266762174e-13 miRanda;mirMAP -0.158050349961081 0.00414021352655968 NA NA NA hsa-miR-590-5p PIK3R1 0.763025362395968 3.65305892505623e-09 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRanda;miRNATAP -0.424270969807281 7.70480985025408e-15 NA NA NA hsa-miR-629-3p PIK3R1 1.43262037314105 2.37092217984413e-19 -1.21900359295309 1.01203266762174e-13 MirTarget -0.192452582760208 1.31715256298262e-05 NA NA NA hsa-miR-93-5p PIK3R1 1.61042951896619 5.1280369606967e-24 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.348791344759735 3.1302460531533e-16 NA NA NA hsa-miR-96-5p PIK3R1 1.42326703011157 4.39736150032373e-14 -1.21900359295309 1.01203266762174e-13 TargetScan;miRNATAP -0.310953673912161 2.47412618125618e-17 NA NA NA hsa-miR-18a-3p PIK3R3 1.82583720936229 7.51297960972179e-19 -0.129019532966171 0.451055967559973 miRNAWalker2_validate -0.103240638013552 0.00398585116122596 NA NA NA hsa-miR-19a-3p PIK3R3 1.35800152353624 2.80940447111944e-12 -0.129019532966171 0.451055967559973 MirTarget;miRNATAP -0.153374017381767 4.01568767526052e-05 NA NA NA hsa-miR-19b-3p PIK3R3 0.538732279378089 0.000622008277870679 -0.129019532966171 0.451055967559973 MirTarget;miRNATAP -0.12996294371586 0.00591308278368021 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.39669186711325 4.36960953138935e-11 -0.129019532966171 0.451055967559973 mirMAP -0.137442753028623 6.48468495867568e-05 NA NA NA hsa-miR-365a-3p PIK3R3 0.446833934952926 0.00233857759218299 -0.129019532966171 0.451055967559973 MirTarget -0.431569400997508 1.46400297130903e-18 NA NA NA hsa-miR-369-3p PIK3R3 -1.2344419076994 2.66882944171146e-10 -0.129019532966171 0.451055967559973 PITA -0.105890967034452 0.00482950119317686 NA NA NA hsa-miR-589-3p PIK3R3 1.59559692667315 6.2886410639161e-15 -0.129019532966171 0.451055967559973 mirMAP -0.138465461387875 0.000168219132587265 NA NA NA hsa-miR-182-5p PIK3R5 1.15060905311096 6.25565852529946e-10 0.15902332125267 0.38685549407615 MirTarget -0.236115638976413 1.63099014479463e-08 NA NA NA hsa-miR-18a-3p PIK3R5 1.82583720936229 7.51297960972179e-19 0.15902332125267 0.38685549407615 MirTarget -0.160296162742907 2.89078394864452e-05 NA NA NA hsa-miR-944 PIK3R5 1.47323925060177 2.61626403984929e-13 0.15902332125267 0.38685549407615 mirMAP -0.211607874388069 3.42384043348289e-08 NA NA NA hsa-miR-149-5p PIK3R6 0.443278770827687 0.0642022866136881 0.45174160714722 0.011740975242753 MirTarget -0.215447740092848 1.78745846182987e-11 NA NA NA hsa-miR-939-5p PIK3R6 1.00479167005165 2.93105661166695e-09 0.45174160714722 0.011740975242753 MirTarget -0.137935647581229 0.00404805376238112 NA NA NA hsa-miR-140-5p PKN2 -0.412389003031485 0.000136051708543369 -0.114436217089763 0.199973357722777 MirTarget;miRanda -0.106799705494755 0.00295483450500518 NA NA NA hsa-miR-199a-5p PKN2 -0.364835768178638 0.0435119211101981 -0.114436217089763 0.199973357722777 miRNATAP -0.125449783674557 3.15686327406643e-09 NA NA NA hsa-miR-320a PKN2 0.801356001806321 4.91397101474502e-09 -0.114436217089763 0.199973357722777 miRanda -0.110731176897143 7.12883910817353e-05 NA NA NA hsa-miR-495-3p PKN2 -1.47803501311999 6.88839745293927e-13 -0.114436217089763 0.199973357722777 mirMAP -0.104739016319276 9.36676170653198e-09 NA NA NA hsa-miR-542-3p PKN2 0.643308814904977 8.81635403230104e-07 -0.114436217089763 0.199973357722777 miRanda -0.105841130545449 0.000315643575657166 NA NA NA hsa-miR-664a-3p PKN2 -0.256108763664991 0.0513188660751664 -0.114436217089763 0.199973357722777 MirTarget -0.170421112482247 5.64831929843825e-09 NA NA NA hsa-miR-193b-3p PKN3 1.72788400801602 3.0722151264559e-21 0.305250713194039 0.0233663292201292 miRNAWalker2_validate -0.12048959496249 8.91844837713023e-05 NA NA NA hsa-miR-664a-3p PPP2CA -0.256108763664991 0.0513188660751664 -0.157094072613604 0.0267322811415248 mirMAP -0.106852242976453 4.77000247252727e-06 NA NA NA hsa-miR-421 PPP2CB 0.945488088619653 2.35762398527362e-09 -0.476022792153769 4.06003367022085e-09 miRNAWalker2_validate;miRanda -0.112192501866666 3.84022796644551e-07 NA NA NA hsa-miR-15b-5p PPP2R1B 0.85315666454713 3.79816274836297e-12 -0.214632147370702 0.032287082704768 MirTarget -0.131544236138784 0.000158748224069463 NA NA NA hsa-miR-30b-5p PPP2R1B -0.400238605368173 0.00346540992719245 -0.214632147370702 0.032287082704768 miRNATAP -0.135040929585792 2.08942951526129e-05 NA NA NA hsa-miR-409-3p PPP2R2A -0.342347118512604 0.0538776384301546 -0.701426942627148 1.05994742317374e-13 PITA -0.103751074240992 1.06323112728475e-05 NA NA NA hsa-miR-450b-5p PPP2R2A 1.25529820885833 1.18847120528666e-15 -0.701426942627148 1.05994742317374e-13 PITA;mirMAP -0.15863049314045 7.04501375156165e-10 NA NA NA hsa-miR-192-5p PPP2R2C 0.380924502586635 0.00986961967409205 0.627078703832598 0.0593896690297092 mirMAP -0.648126510682995 1.97333354822272e-11 NA NA NA hsa-miR-194-5p PPP2R2C -0.0214221838459805 0.872940154118701 0.627078703832598 0.0593896690297092 miRNATAP -0.907089755050328 8.18992632359146e-18 NA NA NA hsa-miR-218-5p PPP2R2C -1.0725338636959 3.61493686604269e-09 0.627078703832598 0.0593896690297092 miRNATAP -0.43028514665884 3.20067951268789e-08 NA NA NA hsa-miR-320a PPP2R2C 0.801356001806321 4.91397101474502e-09 0.627078703832598 0.0593896690297092 MirTarget;PITA;miRanda;miRNATAP -0.550044064334242 1.12818840549332e-07 NA NA NA hsa-miR-320b PPP2R2C 1.23473838180754 3.04337566045537e-14 0.627078703832598 0.0593896690297092 MirTarget;PITA;miRanda;miRNATAP -0.417995504247863 1.33082038645399e-06 NA NA NA hsa-miR-374b-5p PPP2R2C -0.288413933608091 0.0041474558664058 0.627078703832598 0.0593896690297092 miRNATAP -0.817690113646295 1.20840421733783e-08 NA NA NA hsa-miR-502-3p PPP2R2C -0.165138869760313 0.106881047403914 0.627078703832598 0.0593896690297092 MirTarget;PITA;miRNATAP -0.476590393248363 0.000839374168886682 NA NA NA hsa-miR-590-3p PPP2R2C 0.221436901462551 0.0965904764063157 0.627078703832598 0.0593896690297092 miRanda -0.383550194744054 0.000436242415531753 NA NA NA hsa-miR-625-5p PPP2R2C 0.346770617079364 0.02860843739549 0.627078703832598 0.0593896690297092 MirTarget -0.767831126020108 8.73562906211157e-18 NA NA NA hsa-miR-140-3p PPP2R2D -0.967453553824782 7.6999446305445e-23 0.229961518994137 0.000399861225691009 mirMAP -0.144936617380545 1.35289109138347e-07 NA NA NA hsa-miR-106a-5p PPP2R3A 0.67978010057847 0.00221925869726092 -0.147488328623841 0.340577823361896 mirMAP -0.175886260720564 3.61607007894572e-09 NA NA NA hsa-miR-106b-5p PPP2R3A 0.50378717276868 1.45412404526866e-05 -0.147488328623841 0.340577823361896 mirMAP -0.380513721930438 2.21212565551135e-11 NA NA NA hsa-miR-125a-5p PPP2R3A 0.215366061934933 0.119550904549401 -0.147488328623841 0.340577823361896 miRanda -0.169218923983313 0.000519019456263103 NA NA NA hsa-miR-140-5p PPP2R3A -0.412389003031485 0.000136051708543369 -0.147488328623841 0.340577823361896 PITA;miRanda;miRNATAP -0.212094299931209 0.000666386682709331 NA NA NA hsa-miR-148b-3p PPP2R3A 0.386859166050437 4.6728211830726e-06 -0.147488328623841 0.340577823361896 miRNAWalker2_validate -0.438061215485892 3.35987425380875e-08 NA NA NA hsa-miR-17-5p PPP2R3A 1.41924888736771 2.75805544953758e-18 -0.147488328623841 0.340577823361896 mirMAP -0.246939749360929 3.83950618776005e-10 NA NA NA hsa-miR-181a-5p PPP2R3A 0.819060835827404 1.38616688310277e-13 -0.147488328623841 0.340577823361896 MirTarget -0.15570397883901 0.00921272191936763 NA NA NA hsa-miR-181b-5p PPP2R3A 0.974255518824355 2.64876280203475e-16 -0.147488328623841 0.340577823361896 MirTarget -0.144862834504928 0.00873062056454176 NA NA NA hsa-miR-181c-5p PPP2R3A -0.168991199007857 0.196949106150297 -0.147488328623841 0.340577823361896 MirTarget -0.192968491618968 0.000179692964521958 NA NA NA hsa-miR-181d-5p PPP2R3A 0.367649966373544 0.00537300571455306 -0.147488328623841 0.340577823361896 MirTarget -0.134530417438053 0.00847519550581697 NA NA NA hsa-miR-186-5p PPP2R3A 0.353452958261612 0.000145058448579496 -0.147488328623841 0.340577823361896 MirTarget;mirMAP -0.367740070204064 3.52497246842198e-07 NA NA NA hsa-miR-20a-5p PPP2R3A 1.1531986665452 1.02385132917958e-11 -0.147488328623841 0.340577823361896 mirMAP -0.247021556395536 1.17932074515681e-10 NA NA NA hsa-miR-20b-5p PPP2R3A 0.345967670847176 0.232014828043601 -0.147488328623841 0.340577823361896 mirMAP -0.130331754375923 1.44868087897326e-08 NA NA NA hsa-miR-26a-2-3p PPP2R3A -0.444498687388748 0.00325793861409413 -0.147488328623841 0.340577823361896 mirMAP -0.174045745377806 9.00450585280059e-05 NA NA NA hsa-miR-26b-5p PPP2R3A -0.254478038884324 0.0285227763044636 -0.147488328623841 0.340577823361896 miRNATAP -0.321583850866035 2.39323894425268e-08 NA NA NA hsa-miR-320a PPP2R3A 0.801356001806321 4.91397101474502e-09 -0.147488328623841 0.340577823361896 miRanda -0.373395918813958 3.20707710380516e-15 NA NA NA hsa-miR-320b PPP2R3A 1.23473838180754 3.04337566045537e-14 -0.147488328623841 0.340577823361896 miRanda -0.246332712253351 6.36545800207305e-10 NA NA NA hsa-miR-34a-5p PPP2R3A -0.117372471043915 0.364001947180738 -0.147488328623841 0.340577823361896 MirTarget;miRNATAP -0.391529530898388 1.87085809638401e-14 NA NA NA hsa-miR-429 PPP2R3A 0.559451508722375 0.00563641638673083 -0.147488328623841 0.340577823361896 miRanda -0.188364843345204 9.77488636672872e-09 NA NA NA hsa-miR-576-5p PPP2R3A 0.940432050128373 6.90227595663302e-12 -0.147488328623841 0.340577823361896 PITA;mirMAP -0.228554422931037 1.85394709405617e-06 NA NA NA hsa-miR-589-5p PPP2R3A 0.807877250867909 4.12262850391353e-14 -0.147488328623841 0.340577823361896 MirTarget -0.269178367046052 1.21901624544851e-05 NA NA NA hsa-miR-590-3p PPP2R3A 0.221436901462551 0.0965904764063157 -0.147488328623841 0.340577823361896 MirTarget;PITA;miRanda -0.214796101667019 2.09658722932518e-05 NA NA NA hsa-miR-93-5p PPP2R3A 1.61042951896619 5.1280369606967e-24 -0.147488328623841 0.340577823361896 mirMAP -0.27153574654299 7.6149761021663e-12 NA NA NA hsa-miR-140-3p PPP2R5C -0.967453553824782 7.6999446305445e-23 -0.079739932974138 0.203093758954289 MirTarget -0.101657239125858 0.000127153182619392 NA NA NA hsa-miR-15a-5p PPP2R5C 0.783550182002274 2.60699595655907e-11 -0.079739932974138 0.203093758954289 miRNATAP -0.107559980888303 1.90647832582209e-06 NA NA NA hsa-miR-16-5p PPP2R5C 0.521122945828175 1.40561786410572e-06 -0.079739932974138 0.203093758954289 miRNAWalker2_validate;miRNATAP -0.121127644841362 1.0886078966924e-06 NA NA NA hsa-miR-28-3p PPP2R5C 0.459875450032895 3.47095927872566e-07 -0.079739932974138 0.203093758954289 PITA -0.115066147891396 0.000123615638667382 NA NA NA hsa-miR-101-5p PPP2R5E -1.429324744941 4.00032662184937e-18 0.180603227918551 0.0767872681161267 MirTarget -0.121796110333379 2.58193270399917e-06 NA NA NA hsa-miR-125a-5p PPP2R5E 0.215366061934933 0.119550904549401 0.180603227918551 0.0767872681161267 miRNAWalker2_validate -0.258631240828125 1.39238827572283e-16 NA NA NA hsa-miR-148b-5p PPP2R5E 1.1533193737265 7.26420964688337e-13 0.180603227918551 0.0767872681161267 MirTarget -0.102040127003136 0.000184550061310154 NA NA NA hsa-miR-16-2-3p PPP2R5E 1.1567130855258 1.01867256952189e-14 0.180603227918551 0.0767872681161267 mirMAP -0.110374696166335 0.000132085105125086 NA NA NA hsa-miR-181a-5p PPP2R5E 0.819060835827404 1.38616688310277e-13 0.180603227918551 0.0767872681161267 MirTarget;mirMAP -0.191742076509132 9.31441848437386e-07 NA NA NA hsa-miR-181c-5p PPP2R5E -0.168991199007857 0.196949106150297 0.180603227918551 0.0767872681161267 MirTarget;mirMAP -0.193178023621354 9.4099630242982e-09 NA NA NA hsa-miR-181d-5p PPP2R5E 0.367649966373544 0.00537300571455306 0.180603227918551 0.0767872681161267 MirTarget -0.180930186940803 5.64550764686304e-08 NA NA NA hsa-miR-195-3p PPP2R5E -0.624259620429699 0.000164279659144497 0.180603227918551 0.0767872681161267 mirMAP -0.115521563097818 1.49951403071768e-05 NA NA NA hsa-miR-19b-3p PPP2R5E 0.538732279378089 0.000622008277870679 0.180603227918551 0.0767872681161267 miRTarBase;MirTarget -0.139966608931062 5.23560102756024e-07 NA NA NA hsa-miR-217 PPP2R5E -1.35391381055929 2.42394951427902e-09 0.180603227918551 0.0767872681161267 MirTarget -0.123549403585123 6.7106028097879e-11 NA NA NA hsa-miR-29b-2-5p PPP2R5E -0.502720326849742 0.000730448246894952 0.180603227918551 0.0767872681161267 mirMAP -0.205380874921333 1.99345183535714e-12 NA NA NA hsa-miR-30a-3p PPP2R5E -2.26144364746452 8.12421214153823e-31 0.180603227918551 0.0767872681161267 MirTarget -0.103965856060049 8.87868744300167e-07 NA NA NA hsa-miR-30a-5p PPP2R5E -1.79779915425811 1.93360169837799e-26 0.180603227918551 0.0767872681161267 mirMAP -0.194859137906426 1.11619503683474e-15 NA NA NA hsa-miR-30b-5p PPP2R5E -0.400238605368173 0.00346540992719245 0.180603227918551 0.0767872681161267 mirMAP -0.256215189780032 4.77958615637712e-16 NA NA NA hsa-miR-30c-5p PPP2R5E 0.021222006155897 0.886366656528128 0.180603227918551 0.0767872681161267 mirMAP -0.266598706364208 3.13527407356585e-20 NA NA NA hsa-miR-30d-3p PPP2R5E -0.577371911152798 2.02950840095287e-06 0.180603227918551 0.0767872681161267 MirTarget -0.197811183281792 4.13821558112978e-08 NA NA NA hsa-miR-30d-5p PPP2R5E -0.38399848121878 0.000171129616944749 0.180603227918551 0.0767872681161267 mirMAP -0.167248295974402 0.000118757063755921 NA NA NA hsa-miR-30e-3p PPP2R5E -0.890635378639789 1.65740480611339e-16 0.180603227918551 0.0767872681161267 MirTarget -0.145120561430267 0.000289423915946692 NA NA NA hsa-miR-30e-5p PPP2R5E -1.02114836019762 6.81961221797866e-17 0.180603227918551 0.0767872681161267 mirMAP -0.17573392444008 5.36051234374019e-07 NA NA NA hsa-miR-342-3p PPP2R5E 0.99756868977753 9.28499866272332e-10 0.180603227918551 0.0767872681161267 miRanda -0.129489960673769 1.16112498158637e-06 NA NA NA hsa-miR-374a-3p PPP2R5E -0.299190081500425 0.00682975596757891 0.180603227918551 0.0767872681161267 MirTarget -0.198591202168382 6.94641610547591e-07 NA NA NA hsa-miR-374a-5p PPP2R5E -0.621903385111545 6.61791773205282e-12 0.180603227918551 0.0767872681161267 mirMAP -0.162868168428917 0.000782217007253097 NA NA NA hsa-miR-374b-5p PPP2R5E -0.288413933608091 0.0041474558664058 0.180603227918551 0.0767872681161267 mirMAP -0.324006756379648 8.60024893350953e-14 NA NA NA hsa-miR-454-3p PPP2R5E 1.54137391927201 4.15861570449376e-20 0.180603227918551 0.0767872681161267 mirMAP -0.11845766102066 2.87024261453076e-06 NA NA NA hsa-miR-500a-3p PPP2R5E 0.457959128173392 0.000691656736597067 0.180603227918551 0.0767872681161267 MirTarget -0.235973100578834 2.18727093013293e-13 NA NA NA hsa-miR-501-3p PPP2R5E 0.820141346319976 1.74562930463389e-08 0.180603227918551 0.0767872681161267 MirTarget;PITA;TargetScan;miRNATAP -0.123011816760259 4.29572126578338e-05 NA NA NA hsa-miR-576-5p PPP2R5E 0.940432050128373 6.90227595663302e-12 0.180603227918551 0.0767872681161267 mirMAP -0.112573510913937 0.000390545146947586 NA NA NA hsa-miR-15a-5p PRKAA1 0.783550182002274 2.60699595655907e-11 -0.0448262168852596 0.617998429372707 MirTarget -0.156905436702793 1.37446799039965e-06 NA NA NA hsa-miR-19b-3p PRKAA1 0.538732279378089 0.000622008277870679 -0.0448262168852596 0.617998429372707 miRNAWalker2_validate;miRTarBase;miRNATAP -0.109545304680261 8.30801069525184e-06 NA NA NA hsa-miR-29b-3p PRKAA1 -0.110721443686039 0.511264554091106 -0.0448262168852596 0.617998429372707 miRNAWalker2_validate -0.100562103702332 1.31191826414042e-05 NA NA NA hsa-miR-374b-5p PRKAA1 -0.288413933608091 0.0041474558664058 -0.0448262168852596 0.617998429372707 mirMAP -0.103883367130632 0.00781775652081419 NA NA NA hsa-miR-454-3p PRKAA1 1.54137391927201 4.15861570449376e-20 -0.0448262168852596 0.617998429372707 MirTarget;miRNATAP -0.10247726605432 4.12003327060681e-06 NA NA NA hsa-let-7a-3p PRKAA2 0.0966652362351867 0.423761916840503 -3.3470784437381 8.23487674630099e-16 mirMAP -0.611119580423561 7.98502585532926e-05 NA NA NA hsa-let-7f-1-3p PRKAA2 0.700374242293247 8.65000484720084e-08 -3.3470784437381 8.23487674630099e-16 mirMAP -0.487259572982436 0.000560841653796392 NA NA NA hsa-miR-103a-2-5p PRKAA2 1.37988337975616 6.74852943995612e-08 -3.3470784437381 8.23487674630099e-16 mirMAP -0.539822929919598 2.40195295605549e-12 NA NA NA hsa-miR-130a-3p PRKAA2 0.67051191119964 4.89747518735144e-06 -3.3470784437381 8.23487674630099e-16 MirTarget -0.638055466500704 3.58629879630716e-07 NA NA NA hsa-miR-141-3p PRKAA2 0.730011517758706 0.000120338355004032 -3.3470784437381 8.23487674630099e-16 mirMAP -0.416178697461822 1.89540759330245e-05 NA NA NA hsa-miR-146b-5p PRKAA2 0.917975986853978 3.33749259316025e-09 -3.3470784437381 8.23487674630099e-16 MirTarget -0.519924766866759 1.05607879455206e-05 NA NA NA hsa-miR-15b-3p PRKAA2 1.05020782493504 6.38723677324836e-14 -3.3470784437381 8.23487674630099e-16 mirMAP -0.437017461939157 0.00078725458567671 NA NA NA hsa-miR-16-2-3p PRKAA2 1.1567130855258 1.01867256952189e-14 -3.3470784437381 8.23487674630099e-16 mirMAP -0.575199625135728 1.98337798840478e-06 NA NA NA hsa-miR-17-5p PRKAA2 1.41924888736771 2.75805544953758e-18 -3.3470784437381 8.23487674630099e-16 mirMAP -0.864308747211701 1.26060278442975e-15 NA NA NA hsa-miR-181a-5p PRKAA2 0.819060835827404 1.38616688310277e-13 -3.3470784437381 8.23487674630099e-16 mirMAP -0.742825872159103 6.4444540415514e-06 NA NA NA hsa-miR-181b-5p PRKAA2 0.974255518824355 2.64876280203475e-16 -3.3470784437381 8.23487674630099e-16 mirMAP -0.837014766578103 3.22472133301961e-08 NA NA NA hsa-miR-182-5p PRKAA2 1.15060905311096 6.25565852529946e-10 -3.3470784437381 8.23487674630099e-16 miRNAWalker2_validate;MirTarget;mirMAP -0.362449071929737 0.000230854210912145 NA NA NA hsa-miR-186-5p PRKAA2 0.353452958261612 0.000145058448579496 -3.3470784437381 8.23487674630099e-16 MirTarget -0.752276329421756 0.000185884264927097 NA NA NA hsa-miR-19a-3p PRKAA2 1.35800152353624 2.80940447111944e-12 -3.3470784437381 8.23487674630099e-16 mirMAP -0.73118499624708 1.35680433441337e-15 NA NA NA hsa-miR-19b-3p PRKAA2 0.538732279378089 0.000622008277870679 -3.3470784437381 8.23487674630099e-16 mirMAP -0.669616403260058 1.01112552995543e-08 NA NA NA hsa-miR-200a-3p PRKAA2 0.607140814457753 0.00289840524858752 -3.3470784437381 8.23487674630099e-16 mirMAP -0.379939777377135 2.8984541995274e-05 NA NA NA hsa-miR-200c-3p PRKAA2 0.630251054099546 0.000131975031451555 -3.3470784437381 8.23487674630099e-16 MirTarget -0.295905651999808 0.00870783514718382 NA NA NA hsa-miR-203a-3p PRKAA2 0.0441399794719697 0.880456392176704 -3.3470784437381 8.23487674630099e-16 MirTarget -0.40992158532276 5.48305444296988e-11 NA NA NA hsa-miR-20a-5p PRKAA2 1.1531986665452 1.02385132917958e-11 -3.3470784437381 8.23487674630099e-16 mirMAP -0.741150862622723 2.59756622536852e-12 NA NA NA hsa-miR-21-3p PRKAA2 1.25126438776674 2.4124216716282e-17 -3.3470784437381 8.23487674630099e-16 mirMAP -1.00906200551318 2.23214859170938e-17 NA NA NA hsa-miR-22-5p PRKAA2 0.706731861922839 3.44318705980007e-07 -3.3470784437381 8.23487674630099e-16 mirMAP -0.392957976851608 0.0032577569514928 NA NA NA hsa-miR-23a-3p PRKAA2 0.348231698801568 6.4911858506572e-05 -3.3470784437381 8.23487674630099e-16 mirMAP -0.702122647808233 0.00111605781813569 NA NA NA hsa-miR-27b-5p PRKAA2 0.580870079022649 0.000181529223377382 -3.3470784437381 8.23487674630099e-16 MirTarget;miRNATAP -0.436557866300137 0.000261655643298835 NA NA NA hsa-miR-301a-3p PRKAA2 2.14132004241926 4.46255413526808e-25 -3.3470784437381 8.23487674630099e-16 MirTarget -0.566247147035862 1.89997128006839e-11 NA NA NA hsa-miR-31-5p PRKAA2 2.79079137807505 1.72181058015659e-13 -3.3470784437381 8.23487674630099e-16 MirTarget -0.472854026119331 2.44026859889055e-24 NA NA NA hsa-miR-331-3p PRKAA2 0.906385914819361 4.27653809739414e-11 -3.3470784437381 8.23487674630099e-16 MirTarget -0.35963781665794 0.00714942766572411 NA NA NA hsa-miR-342-3p PRKAA2 0.99756868977753 9.28499866272332e-10 -3.3470784437381 8.23487674630099e-16 PITA -0.472020333235437 2.63832918178842e-05 NA NA NA hsa-miR-429 PRKAA2 0.559451508722375 0.00563641638673083 -3.3470784437381 8.23487674630099e-16 MirTarget;miRNATAP -0.238354734769169 0.00972265295199331 NA NA NA hsa-miR-452-3p PRKAA2 1.09618110917892 2.21867884261816e-07 -3.3470784437381 8.23487674630099e-16 mirMAP -0.376036025718865 1.44865050274686e-05 NA NA NA hsa-miR-454-3p PRKAA2 1.54137391927201 4.15861570449376e-20 -3.3470784437381 8.23487674630099e-16 MirTarget -0.769000443316249 2.22740451533364e-13 NA NA NA hsa-miR-500a-5p PRKAA2 0.675401699376111 8.24389004707854e-05 -3.3470784437381 8.23487674630099e-16 mirMAP -0.370089325264102 0.000616140983813196 NA NA NA hsa-miR-576-5p PRKAA2 0.940432050128373 6.90227595663302e-12 -3.3470784437381 8.23487674630099e-16 mirMAP -1.06364860334457 2.94950846997241e-16 NA NA NA hsa-miR-589-5p PRKAA2 0.807877250867909 4.12262850391353e-14 -3.3470784437381 8.23487674630099e-16 MirTarget -0.773044469338115 5.75330157138291e-06 NA NA NA hsa-miR-7-1-3p PRKAA2 1.13646121619622 1.49823237535933e-14 -3.3470784437381 8.23487674630099e-16 MirTarget;mirMAP -0.615777535046871 4.71256321695788e-07 NA NA NA hsa-miR-93-5p PRKAA2 1.61042951896619 5.1280369606967e-24 -3.3470784437381 8.23487674630099e-16 mirMAP -0.472036673630309 2.28625034490348e-05 NA NA NA hsa-miR-944 PRKAA2 1.47323925060177 2.61626403984929e-13 -3.3470784437381 8.23487674630099e-16 mirMAP -0.513120238556238 9.40471370250645e-09 NA NA NA hsa-miR-96-5p PRKAA2 1.42326703011157 4.39736150032373e-14 -3.3470784437381 8.23487674630099e-16 TargetScan -0.418320078480582 1.32057548932296e-05 NA NA NA hsa-miR-103a-2-5p PRKCA 1.37988337975616 6.74852943995612e-08 0.3178322857115 0.0462170958036427 mirMAP -0.117780407567177 5.24493745308123e-05 NA NA NA hsa-miR-150-5p PRKCA -0.243749814009231 0.331546276920338 0.3178322857115 0.0462170958036427 mirMAP -0.104022182991935 0.000162874861270433 NA NA NA hsa-miR-17-3p PRKCA -0.0127974722290336 0.909559935689875 0.3178322857115 0.0462170958036427 miRNAWalker2_validate -0.214761659225552 0.000540115676811066 NA NA NA hsa-miR-181c-5p PRKCA -0.168991199007857 0.196949106150297 0.3178322857115 0.0462170958036427 mirMAP -0.230481828890932 1.38543638100701e-05 NA NA NA hsa-miR-183-5p PRKCA 1.4313129319945 6.25230916431996e-14 0.3178322857115 0.0462170958036427 miRNATAP -0.123604672252822 0.000489233186271866 NA NA NA hsa-miR-186-5p PRKCA 0.353452958261612 0.000145058448579496 0.3178322857115 0.0462170958036427 miRNATAP -0.197395594611936 0.008653002308399 NA NA NA hsa-miR-1976 PRKCA 0.638808083289405 2.94840228896364e-07 0.3178322857115 0.0462170958036427 miRNATAP -0.216146135639291 9.07994360436659e-05 NA NA NA hsa-miR-19b-1-5p PRKCA 0.757034032029085 2.99828133413343e-07 0.3178322857115 0.0462170958036427 mirMAP -0.214408086876696 3.69042545103291e-06 NA NA NA hsa-miR-200b-3p PRKCA 0.0717138787925347 0.682858087587209 0.3178322857115 0.0462170958036427 TargetScan -0.341691724440131 5.17210999735547e-19 NA NA NA hsa-miR-200c-3p PRKCA 0.630251054099546 0.000131975031451555 0.3178322857115 0.0462170958036427 miRNATAP -0.258050454876613 4.38353493232271e-10 NA NA NA hsa-miR-24-2-5p PRKCA 1.27293931700635 4.48240091510596e-15 0.3178322857115 0.0462170958036427 miRNAWalker2_validate -0.121435567912037 0.00357611288622236 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-27b-5p PRKCA 0.580870079022649 0.000181529223377382 0.3178322857115 0.0462170958036427 mirMAP -0.227514723686497 2.70991772299128e-07 NA NA NA hsa-miR-29b-2-5p PRKCA -0.502720326849742 0.000730448246894952 0.3178322857115 0.0462170958036427 mirMAP -0.296683337612196 9.93635847649949e-11 NA NA NA hsa-miR-30d-3p PRKCA -0.577371911152798 2.02950840095287e-06 0.3178322857115 0.0462170958036427 mirMAP -0.332961077885486 3.40360771990262e-09 NA NA NA hsa-miR-30e-3p PRKCA -0.890635378639789 1.65740480611339e-16 0.3178322857115 0.0462170958036427 mirMAP -0.199675307499267 0.00146746163627339 NA NA NA hsa-miR-339-5p PRKCA 1.07771430326938 2.45772601859307e-09 0.3178322857115 0.0462170958036427 mirMAP -0.148559462896231 8.30706937469769e-05 NA NA NA hsa-miR-3607-3p PRKCA 1.01377165357363 9.13355519701165e-05 0.3178322857115 0.0462170958036427 mirMAP -0.133480273866349 4.39877789751401e-07 NA NA NA hsa-miR-362-5p PRKCA 0.41089772861323 0.0404254902071382 0.3178322857115 0.0462170958036427 TargetScan;miRNATAP -0.223333590994173 5.47462768229892e-11 NA NA NA hsa-miR-374a-5p PRKCA -0.621903385111545 6.61791773205282e-12 0.3178322857115 0.0462170958036427 mirMAP -0.205530215602705 0.00688190144820459 NA NA NA hsa-miR-429 PRKCA 0.559451508722375 0.00563641638673083 0.3178322857115 0.0462170958036427 miRanda;miRNATAP -0.266671632635371 1.42360916592268e-15 NA NA NA hsa-miR-500a-5p PRKCA 0.675401699376111 8.24389004707854e-05 0.3178322857115 0.0462170958036427 miRNATAP -0.174713694092824 1.31490069031191e-05 NA NA NA hsa-miR-501-5p PRKCA 1.02806906860218 1.63456814370548e-09 0.3178322857115 0.0462170958036427 miRNATAP -0.164099616970046 5.18294254195767e-05 NA NA NA hsa-miR-505-5p PRKCA 1.25888458076414 7.80089782306577e-13 0.3178322857115 0.0462170958036427 mirMAP -0.108990500629565 0.00483820175668253 NA NA NA hsa-miR-532-3p PRKCA 0.80240056676907 1.08989551712617e-09 0.3178322857115 0.0462170958036427 mirMAP;miRNATAP -0.201724862387695 0.000103690896052721 NA NA NA hsa-miR-590-3p PRKCA 0.221436901462551 0.0965904764063157 0.3178322857115 0.0462170958036427 PITA;miRanda;mirMAP;miRNATAP -0.159630241178647 0.00227859309388304 NA NA NA hsa-miR-92a-3p PRKCA 0.994679542307232 1.32587679156217e-16 0.3178322857115 0.0462170958036427 miRNAWalker2_validate -0.239077901540622 1.99085302915519e-05 NA NA NA hsa-miR-93-3p PRKCA 1.69225547123293 1.50964095575087e-25 0.3178322857115 0.0462170958036427 mirMAP -0.142996896050503 0.000455152507074917 NA NA NA hsa-let-7a-3p PRLR 0.0966652362351867 0.423761916840503 -1.30787264357825 0.000471474755219158 mirMAP -0.512701701055818 0.000164195588073901 NA NA NA hsa-let-7d-5p PRLR 0.481757661442508 3.66030810124939e-07 -1.30787264357825 0.000471474755219158 miRNATAP -0.480531634644174 0.00546237376205416 NA NA NA hsa-let-7f-1-3p PRLR 0.700374242293247 8.65000484720084e-08 -1.30787264357825 0.000471474755219158 mirMAP -0.433240907145624 0.000472931993455816 NA NA NA hsa-miR-103a-2-5p PRLR 1.37988337975616 6.74852943995612e-08 -1.30787264357825 0.000471474755219158 mirMAP -0.294265559991193 1.78344449895191e-05 NA NA NA hsa-miR-130a-3p PRLR 0.67051191119964 4.89747518735144e-06 -1.30787264357825 0.000471474755219158 mirMAP -0.524104230206842 1.97264872216105e-06 NA NA NA hsa-miR-130b-3p PRLR 1.44628430084411 9.13980959861273e-24 -1.30787264357825 0.000471474755219158 mirMAP -0.359905948871644 0.000944686290777868 NA NA NA hsa-miR-15b-3p PRLR 1.05020782493504 6.38723677324836e-14 -1.30787264357825 0.000471474755219158 mirMAP -0.399837324622169 0.000462570490348866 NA NA NA hsa-miR-16-1-3p PRLR 0.955017760172879 5.95379292601146e-11 -1.30787264357825 0.000471474755219158 mirMAP -0.336245037970807 0.0023652776899924 NA NA NA hsa-miR-182-5p PRLR 1.15060905311096 6.25565852529946e-10 -1.30787264357825 0.000471474755219158 miRNATAP -0.249382765635961 0.00397861414708402 NA NA NA hsa-miR-196b-5p PRLR 3.78958266598891 1.12771732893771e-44 -1.30787264357825 0.000471474755219158 miRNATAP -0.201137841350913 0.000269777553933088 NA NA NA hsa-miR-19b-1-5p PRLR 0.757034032029085 2.99828133413343e-07 -1.30787264357825 0.000471474755219158 mirMAP -0.600855059067166 3.28773829877233e-08 NA NA NA hsa-miR-20a-3p PRLR 1.34885093664027 2.07697464119202e-12 -1.30787264357825 0.000471474755219158 mirMAP -0.436935799896661 1.2825302457752e-07 NA NA NA hsa-miR-26a-2-3p PRLR -0.444498687388748 0.00325793861409413 -1.30787264357825 0.000471474755219158 mirMAP -0.319449331019102 0.00322643735843453 NA NA NA hsa-miR-29a-5p PRLR 0.323252792625584 0.0370417231222825 -1.30787264357825 0.000471474755219158 mirMAP -0.368627642456112 0.00048176748385086 NA NA NA hsa-miR-301a-3p PRLR 2.14132004241926 4.46255413526808e-25 -1.30787264357825 0.000471474755219158 mirMAP -0.263803774296363 0.000450204776519736 NA NA NA hsa-miR-320a PRLR 0.801356001806321 4.91397101474502e-09 -1.30787264357825 0.000471474755219158 miRanda -0.523459199972559 8.48081441802328e-06 NA NA NA hsa-miR-320b PRLR 1.23473838180754 3.04337566045537e-14 -1.30787264357825 0.000471474755219158 miRanda -0.334787456285682 0.000649581616061883 NA NA NA hsa-miR-374a-3p PRLR -0.299190081500425 0.00682975596757891 -1.30787264357825 0.000471474755219158 mirMAP -0.41433744454592 0.00538517607267949 NA NA NA hsa-miR-374b-3p PRLR 0.425603499218802 0.00146686864653282 -1.30787264357825 0.000471474755219158 mirMAP -0.518216948701422 2.30511112828655e-05 NA NA NA hsa-miR-454-3p PRLR 1.54137391927201 4.15861570449376e-20 -1.30787264357825 0.000471474755219158 mirMAP -0.413431991391847 9.84309936266268e-06 NA NA NA hsa-miR-501-5p PRLR 1.02806906860218 1.63456814370548e-09 -1.30787264357825 0.000471474755219158 mirMAP -0.263528034801935 0.00604534975627035 NA NA NA hsa-miR-576-5p PRLR 0.940432050128373 6.90227595663302e-12 -1.30787264357825 0.000471474755219158 mirMAP -0.477474519090289 4.43457828795712e-05 NA NA NA hsa-miR-582-5p PRLR -0.0366995972742474 0.821827119138923 -1.30787264357825 0.000471474755219158 PITA -0.398109988033518 7.37537201947536e-05 NA NA NA hsa-miR-589-3p PRLR 1.59559692667315 6.2886410639161e-15 -1.30787264357825 0.000471474755219158 mirMAP -0.338642940521925 2.77063739189816e-05 NA NA NA hsa-miR-7-1-3p PRLR 1.13646121619622 1.49823237535933e-14 -1.30787264357825 0.000471474755219158 mirMAP -0.60138070070372 1.88226549150637e-08 NA NA NA hsa-miR-9-5p PRLR 1.65694862043766 2.08325802567323e-05 -1.30787264357825 0.000471474755219158 miRNATAP -0.110968323939938 0.00776842585282018 NA NA NA hsa-miR-944 PRLR 1.47323925060177 2.61626403984929e-13 -1.30787264357825 0.000471474755219158 mirMAP -0.422976307830314 7.35863725072358e-08 NA NA NA hsa-miR-96-5p PRLR 1.42326703011157 4.39736150032373e-14 -1.30787264357825 0.000471474755219158 miRNATAP -0.32127974264967 0.000142163243405471 NA NA NA hsa-miR-103a-3p PTEN 0.556219385347418 1.55815736455067e-09 -0.105559265617794 0.259478904420102 miRNAWalker2_validate;miRTarBase -0.212301381039792 1.12994240930338e-06 26511107;24828205 LncRNA GAS5 induces PTEN expression through inhibiting miR 103 in endometrial cancer cells; To investigate the expression of GAS5 PTEN and miR-103 RT-PCR was performed; Finally we found that miR-103 mimic could decrease the mRNA and protein levels of PTEN through luciferase reporter assay and western blotting and GAS5 plasmid may reverse this regulation effect in endometrial cancer cells; Through inhibiting the expression of miR-103 GAS5 significantly enhanced the expression of PTEN to promote cancer cell apoptosis and thus could be an important mediator in the pathogenesis of endometrial cancer;Our data collectively demonstrate that miR-103 is an oncogene miRNA that promotes colorectal cancer proliferation and migration through down-regulation of the tumor suppressor genes DICER and PTEN ; endometrial cancer;colorectal cancer hsa-miR-106a-5p PTEN 0.67978010057847 0.00221925869726092 -0.105559265617794 0.259478904420102 miRNATAP -0.106146372576128 3.66470578195619e-09 26097565;26318586 miR 106a promotes growth and metastasis of non small cell lung cancer by targeting PTEN; Furthermore the presence of miR-106a was inversely correlated with PTEN in NSCLC tissues; Overall this study suggested that miR-106a inhibited the growth and metastasis of NSCLC cells by decreasing PTEN expression;Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo metastasis; lung squamous cell cancer;prostate cancer hsa-miR-106b-5p PTEN 0.50378717276868 1.45412404526866e-05 -0.105559265617794 0.259478904420102 miRNAWalker2_validate;miRTarBase;miRNATAP -0.174826094407509 4.51369872456834e-07 24842611;26238857;26722252 MicroRNA 106b in cancer associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN;We further identified PTEN and p21 as novel direct targets of miR-106b by using target prediction algorithms and a luciferase assay; Overexpression of miR-106b reduced the expression of PTEN and p21 and increased the expression of p-AKT which is a downstream of PTEN; Restoring the expression of PTEN or p21 in stably miR-106b-overexpressed cells could rescue the effect of miR-106b on cell radioresistance; These observations illustrated that miR-106b could induce cell radioresistance by directly targeting PTEN and p21 this process was accompanied by tumour-initiating cell capacity enhancement which is universally confirmed to be associated with radioresistance;Cantharidin modulates the E2F1/MCM7 miR 106b 93/p21 PTEN signaling axis in MCF 7 breast cancer cells cell migration;drug resistance; gastric cancer;colorectal cancer;breast cancer hsa-miR-130b-3p PTEN 1.44628430084411 9.13980959861273e-24 -0.105559265617794 0.259478904420102 MirTarget;miRNATAP -0.12763831354529 2.02162718248739e-06 26837847;25637514 The miR 130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN; In clinical bladder cancer specimens downregulation of PTEN was found to be closely correlated with miR-130 family expression levels;MiR 130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells; We confirmed that miR-130b interacted with the 3'-untranslated region of PTEN and that an increase in the expression level of miR-130b negatively affected the protein level of PTEN; However the dysregulation of miR-130b had no obvious impact on PTEN mRNA; As Akt is a downstream effector of PTEN we explored if miR-130b affected Akt expression and found that miR-130b indirectly regulated the level of phosphorylated Akt while total Akt protein remained unchanged; The results indicate that miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation which would be helpful in developing miRNA-based treatments for ESCC cell migration; bladder cancer;esophageal cancer hsa-miR-141-3p PTEN 0.730011517758706 0.000120338355004032 -0.105559265617794 0.259478904420102 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.125754501440233 2.19301445533495e-09 27644195;24742567 Involvement of microRNA 141 3p in 5 fluorouracil and oxaliplatin chemo resistance in esophageal cancer cells via regulation of PTEN; Western blot exhibited altered protein levels of PTEN Akt and PI3k with miR-141-3p inhibitor; An inverse correlation between PTEN expression and miR-141-3p expression was also observed in tissue samples; Our study demonstrated that miR-141-3p contributed to an acquired chemo-resistance through PTEN modulation both in vitro and in vivo;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis drug resistance;tumorigenesis esophageal cancer;endometrial cancer hsa-miR-15b-3p PTEN 1.05020782493504 6.38723677324836e-14 -0.105559265617794 0.259478904420102 mirMAP -0.149806075215585 9.98966845863658e-08 NA NA NA hsa-miR-16-1-3p PTEN 0.955017760172879 5.95379292601146e-11 -0.105559265617794 0.259478904420102 MirTarget -0.101536030757984 0.000209771919825589 NA NA NA hsa-miR-16-2-3p PTEN 1.1567130855258 1.01867256952189e-14 -0.105559265617794 0.259478904420102 mirMAP -0.140201599486745 9.49304636851156e-08 NA NA NA hsa-miR-17-5p PTEN 1.41924888736771 2.75805544953758e-18 -0.105559265617794 0.259478904420102 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.140106850111196 4.3473859521156e-09 27400681;23391506;23133552;26629823;24462867;26318586;26215320;25634356;26500892;24912422;23418359 GFRα2 prompts cell growth and chemoresistance through down regulating tumor suppressor gene PTEN via Mir 17 5p in pancreatic cancer; Mechanically we discovered that high GFRα2 expression level leads to PTEN inactivation via enhancing Mir-17-5p level;We found that these phenotypes were the results of miR-17 targeting PTEN;PTEN mRNA correlated inversely with miR-92a and members of the miR-17 and miR-130/301 families;We hypothesized that knocking down the oncogenic microRNA oncomiR miR-17-5p might restore the expression levels of PDCD4 and PTEN tumor suppressor proteins illustrating a route to oligonucleotide therapy of TNBC; Contrary to conventional wisdom antisense knockdown of oncomiR miR-17-5p guide strand reduced PDCD4 and PTEN proteins by 1.8±0.3 fold in human TNBC cells instead of raising them; Bioinformatics analysis and folding energy calculations revealed that mRNA targets of miR-17-5p guide strand such as PDCD4 and PTEN could also be regulated by miR-17-3p passenger strand;miR 17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression; Expression of miR-17 was negatively correlated with PTEN in OS tissues;Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR 17 family in prostate cancer; Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo;In addition ERβ expression significantly increased in calycosin-treated HCT-116 cells followed by a decrease of miR-17 and up-regulation of PTEN; Our results indicate that calycosin has an inhibitory effect on CRC which might be obtained by ERβ-mediated regulation of miR-17 and PTEN expression;The High Expression of the microRNA 17 92 Cluster and its Paralogs and the Downregulation of the Target Gene PTEN Is Associated with Primary Cutaneous B Cell Lymphoma Progression;MicroRNA 17 5p induces drug resistance and invasion of ovarian carcinoma cells by targeting PTEN signaling; miR-17-5p activates AKT by downregulation of PTEN in ovarian cancer cells;MicroRNA 17 5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression; We found that PTEN was a target of miR-17-5p in the colon cancer cells and their context-specific interactions were responsible for multiple drug-resistance; Chemotherapy was found to increase the expression levels of miR-17-5p which further repressed PTEN levels contributing to the development of chemo-resistance; MiR-17-5p is a predictive factor for chemotherapy response and a prognostic factor for overall survival in CRC which is due to its regulation of PTEN expression;The mature miR-17-5p exerted this function by repressing the expression of PTEN drug resistance;;;;metastasis;;;progression;drug resistance;metastasis;drug resistance;poor survival; pancreatic cancer;glioblastoma;sarcoma;breast cancer;sarcoma;prostate cancer;colorectal cancer;B cell lymphoma;ovarian cancer;colorectal cancer;liver cancer hsa-miR-182-5p PTEN 1.15060905311096 6.25565852529946e-10 -0.105559265617794 0.259478904420102 mirMAP -0.129020080970652 1.15688418944506e-09 NA NA NA hsa-miR-186-5p PTEN 0.353452958261612 0.000145058448579496 -0.105559265617794 0.259478904420102 mirMAP;miRNATAP -0.157331259101545 0.000334733432007599 NA NA NA hsa-miR-188-5p PTEN 0.559328953885106 0.000430338888594543 -0.105559265617794 0.259478904420102 MirTarget;PITA;miRNATAP -0.116715312390083 4.58343088299575e-06 NA NA NA hsa-miR-19b-3p PTEN 0.538732279378089 0.000622008277870679 -0.105559265617794 0.259478904420102 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.141954274984075 2.53034214678501e-08 26098000;24831732;21853360;24681249 Moreover siRNA-mediated knockdown of PTEN a target of miR-19 also resulted in EMT migration and invasion of A549 and HCC827 cells suggesting that PTEN is involved in miR-19-induced EMT migration and invasion of lung cancer cells;Meanwhile BPA-induced upregulation of oncogenic miR-19a and miR-19b and the dysregulated expression of miR-19-related downstream proteins including PTEN p-AKT p-MDM2 p53 and proliferating cell nuclear antigen were reversed by curcumin;Regulation of miR 19 to breast cancer chemoresistance through targeting PTEN; Expression levels of miR-19 in MDR cells were inversely consistent with those of PTEN; Our findings demonstrate for the first time involvement of miR-19 in multidrug resistance through modulation of PTEN and suggest that miR-19 may be a potential target for preventing and reversing MDR in tumor cells;miR-19 in the context of the miR-17~92 cluster at medium levels promoted tumor metastasis through induction of Wnt/β-catenin-mediated epithelial-mesenchymal transition by targeting to the tumor-suppressor gene PTEN ;;drug resistance;metastasis lung cancer;breast cancer;breast cancer;colon cancer hsa-miR-200a-3p PTEN 0.607140814457753 0.00289840524858752 -0.105559265617794 0.259478904420102 miRNATAP -0.148111731349853 2.35958613974647e-14 22637745;24742567;21408027 Re expression of miR 200 by novel approaches regulates the expression of PTEN and MT1 MMP in pancreatic cancer; We initially compared the expression profile of miR-200 family PTEN and MT1-MMP expression in six pancreatic cancer PC cell lines by qRT-PCR and western blot analysis; We found loss of expression of miR-200a b and c in chemo-resistant PC cell lines which was correlated with loss of PTEN and over-expression of MT1-MMP; The expression of miR-200 family and PTEN was significantly re-expressed whereas the expression of MT1-MMP was down-regulated by CDF and BR-DIM treatment; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants ;tumorigenesis; pancreatic cancer;endometrial cancer;pancreatic cancer hsa-miR-200b-3p PTEN 0.0717138787925347 0.682858087587209 -0.105559265617794 0.259478904420102 TargetScan;mirMAP -0.171021772729679 4.66573539439015e-14 22637745;21408027 Re expression of miR 200 by novel approaches regulates the expression of PTEN and MT1 MMP in pancreatic cancer; We initially compared the expression profile of miR-200 family PTEN and MT1-MMP expression in six pancreatic cancer PC cell lines by qRT-PCR and western blot analysis; The expression of miR-200 family and PTEN was significantly re-expressed whereas the expression of MT1-MMP was down-regulated by CDF and BR-DIM treatment; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants ; pancreatic cancer;pancreatic cancer hsa-miR-200c-3p PTEN 0.630251054099546 0.000131975031451555 -0.105559265617794 0.259478904420102 mirMAP;miRNATAP -0.11197157521581 4.46533092344619e-06 24682933;22637745 In conclusion miR-200c functions as an oncogene in colon cancer cells through regulating tumor cell apoptosis survival invasion and metastasis as well as xenograft tumor growth through inhibition of PTEN expression and p53 phosphorylation;Forced over-expression or silencing of miR-200c followed by either CDF or BR-DIM treatment of MIAPaCa-2 cells altered the morphology of cells wound-healing capacity colony formation and the expression of MT1-MMP and PTEN; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment metastasis;poor survival; colon cancer;pancreatic cancer hsa-miR-20a-5p PTEN 1.1531986665452 1.02385132917958e-11 -0.105559265617794 0.259478904420102 miRNAWalker2_validate;miRTarBase;miRNATAP -0.146702630345827 2.40532820370931e-10 26031366 The expression of miR-20a and PTEN were detected in HCC cell lines and paired primary tissues by quantitative real-time polymerase chain reaction; MiR-20a levels were increased in HCC cell lines and tissues whereas PTEN was inversely correlated with it; PTEN was identified as a direct functional target of miR-20a for the induction of radioresistance drug resistance liver cancer hsa-miR-20b-5p PTEN 0.345967670847176 0.232014828043601 -0.105559265617794 0.259478904420102 miRNATAP -0.100046689111042 3.39404588539732e-13 23945289;24468585;27701465;25364498 In vitro RNA-pull down assays indicated that miR-20b targets numerous tumor suppressors including PTEN and BRCA1 which were downregulated in HCC1806; Conversely suppression of miR-20b increased PTEN and BRCA1 levels;Finally the impact of these up-regulated miRNAs on PTEN expression was tested by using dual-luciferase reporter assay system from which the results indicated that miR-20b -21 and -130b were involved in suppression of PTEN expression; These findings suggest that miR-20b -21 and -130b up-regulated in colorectal cancer through inhibiting the expression of PTEN result in B7-H1 over-expression in colorectal cancer;Additionally the 3'-untranslated region 3'-UTR of phosphatase and tensin homologue PTEN binding with miR-20b was analyzed by dual-luciferase reporter assays; The results indicated that miR-20b expression level in esophageal tumor tissues was significantly increased compared with their neighboring normal tissues but its expression was inverse with PTEN protein expression; Luciferase assays confirmed that the 3'-UTR of PTEN was a target of miR-20b in esophageal cancer cells; MiR-20b upregulation promoted cell proliferation migration invasiveness and tumor growth and decreased apoptosis and reduced PTEN protein level but not mRNA expression in Eca-109 cells; Conversely downregulation of miR-20b suppressed these processes in KYSE-150 cells and enhanced PTEN protein expression; These data indicate that miR-20b plays important roles in tumorigenesis of esophageal cancer possibly via regulation of PTEN expression and it may be a potential therapeutic target for esophageal cancer treatment;MicroRNA 20b promotes cell growth of breast cancer cells partly via targeting phosphatase and tensin homologue PTEN; We identified PTEN a well-known tumor suppressor as the functional downstream target of miR-20b; Luciferase assays confirmed that miR-20b could directly bind to the 3' untranslated regionUTR of PTEN and suppress translation; Alteration of miR-20b expression changed PTEN protein level but not mRNA expression in ZR-75-30 and MCF-7 breast cancer cells suggesting miR-20b regulates PTEN gene expression at the posttranscriptional level; Dysregulation of miR-20b plays critical roles in the breast cancer tumorigenesis at least in part via targeting the tumor suppressor PTEN ;;tumorigenesis;tumorigenesis breast cancer;colorectal cancer;esophageal cancer;breast cancer hsa-miR-25-3p PTEN 0.76549796417801 3.32282098247097e-11 -0.105559265617794 0.259478904420102 miRTarBase;MirTarget;miRNATAP -0.2479570822814 3.10997599301382e-13 NA NA NA hsa-miR-26b-5p PTEN -0.254478038884324 0.0285227763044636 -0.105559265617794 0.259478904420102 MirTarget;miRNATAP -0.119107310036174 0.000693884471580411 26068649 Down regulation of microRNA 26b modulates non small cell lung cancer cells chemoresistance and migration through the association of PTEN; It indicates that miR-26b may regulate NSCLC migration and chemosensitivity through the regulation of PTEN drug resistance lung squamous cell cancer hsa-miR-28-5p PTEN -0.026996999089909 0.733047113251652 -0.105559265617794 0.259478904420102 miRanda -0.148078581199056 0.00466758423516303 NA NA NA hsa-miR-29b-3p PTEN -0.110721443686039 0.511264554091106 -0.105559265617794 0.259478904420102 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.104140290718439 1.49268174826838e-05 26471361;23179556;26063204;21359530 Mechanistically ATDC exerted its oncogenic effects by suppressing miR-29 and subsequent upregulation of DNMT3A leading to DNA methylation and silencing of the tumor suppressor PTEN;Anticancer role of MUC1 aptamer miR 29b chimera in epithelial ovarian carcinoma cells through regulation of PTEN methylation; Our study indicated that Chi-29b chimera can effectively exert antitumor effect through specific delivery of miR-29b into OVCAR-3 tumor cells subsequently reexpressing PTEN gene and inducing cell apoptosis;Furthermore the dual-luciferase reporter assay demonstrated that miR-29b inhibited the expression of the luciferase gene containing the 3'-UTRs of MMP2 and PTEN mRNA;In contrast enhanced miR-29b expression by transfection with pre-miR-29b decreased the expression of PTEN and impaired apoptosis increasing tumor cell migration and invasion; Moreover PTEN was shown to be a direct target of miR-29b and was also shown to contribute to the miR-29b-mediated effects on cell invasion; Modulation of miR-29b altered the role of PTEN involved in cell migration and invasion; Aberrant expression of miR-29b which modulates PTEN expression can contribute to migration invasion and anti-apoptosis ;;;cell migration bladder cancer;ovarian cancer;lung squamous cell cancer;breast cancer hsa-miR-30b-5p PTEN -0.400238605368173 0.00346540992719245 -0.105559265617794 0.259478904420102 mirMAP -0.167292628386744 1.22945082617617e-08 NA NA NA hsa-miR-30c-5p PTEN 0.021222006155897 0.886366656528128 -0.105559265617794 0.259478904420102 mirMAP -0.156825954386916 7.65587626809304e-09 NA NA NA hsa-miR-30d-3p PTEN -0.577371911152798 2.02950840095287e-06 -0.105559265617794 0.259478904420102 MirTarget;miRNATAP -0.199701101668772 1.32292586130764e-09 NA NA NA hsa-miR-30d-5p PTEN -0.38399848121878 0.000171129616944749 -0.105559265617794 0.259478904420102 mirMAP -0.220188562855424 2.47717470197967e-08 NA NA NA hsa-miR-30e-5p PTEN -1.02114836019762 6.81961221797866e-17 -0.105559265617794 0.259478904420102 mirMAP -0.117105233149191 0.000287532519172905 NA NA NA hsa-miR-320a PTEN 0.801356001806321 4.91397101474502e-09 -0.105559265617794 0.259478904420102 MirTarget;PITA;miRanda;miRNATAP -0.141503454711623 1.18141156695628e-06 NA NA NA hsa-miR-335-3p PTEN 0.336785882180547 0.0542446207938138 -0.105559265617794 0.259478904420102 MirTarget -0.112677059847725 1.04070864873638e-06 NA NA NA hsa-miR-374b-5p PTEN -0.288413933608091 0.0041474558664058 -0.105559265617794 0.259478904420102 MirTarget;mirMAP;miRNATAP -0.16851732961829 3.18032198525689e-05 NA NA NA hsa-miR-429 PTEN 0.559451508722375 0.00563641638673083 -0.105559265617794 0.259478904420102 PITA;miRanda;mirMAP;miRNATAP -0.150523780429582 1.52917738778381e-14 NA NA NA hsa-miR-454-3p PTEN 1.54137391927201 4.15861570449376e-20 -0.105559265617794 0.259478904420102 MirTarget;miRNATAP -0.109685346766956 2.22248900040344e-06 26296312;27261580 MicroRNA 454 functions as an oncogene by regulating PTEN in uveal melanoma; Furthermore we identified PTEN as a direct target of miR-454; Our data revealed that ectopic expression of PTEN restored the effects of miR-454 on cell proliferation and invasion in uveal melanoma cells;MiR 454 promotes the progression of human non small cell lung cancer and directly targets PTEN; At last the potential regulatory function of miR-454 on PTEN expression was confirmed; Further PTEN was confirmed as a direct target of miR-454 by using Luciferase Reporter Assay ;progression melanoma;lung squamous cell cancer hsa-miR-532-5p PTEN -0.021857649390892 0.830992272120134 -0.105559265617794 0.259478904420102 PITA;mirMAP;miRNATAP -0.202965037131022 3.33044253297789e-07 NA NA NA hsa-miR-582-3p PTEN -0.248056267546012 0.143798829508405 -0.105559265617794 0.259478904420102 PITA -0.104272846654196 1.24824461296463e-05 NA NA NA hsa-miR-590-5p PTEN 0.763025362395968 3.65305892505623e-09 -0.105559265617794 0.259478904420102 mirMAP -0.14144429591082 4.70302286754264e-06 23803188 Targetscan predicted PDCD4 and PTEN as the potential target genes of miR-590-5p and miR-590-3p which was verified by luciferase reporter system and Western blotting liver cancer hsa-miR-7-1-3p PTEN 1.13646121619622 1.49823237535933e-14 -0.105559265617794 0.259478904420102 mirMAP -0.124388298964707 3.10112587036933e-06 NA NA NA hsa-miR-92a-3p PTEN 0.994679542307232 1.32587679156217e-16 -0.105559265617794 0.259478904420102 MirTarget;miRNATAP -0.200124132359 7.23918085276245e-10 26432332;25515201;24137349;23546593;23133552;24026406 Downregulation of PTEN could mimic the same effects of miR-92a mimic in NSCLC cells and rescue the effects on NSCLC cells induced by miR-92a inhibitor; Taken together these findings suggested that miR-92a could promote growth metastasis and chemoresistance in NSCLC cells at least partially by targeting PTEN;MiR 92a Promotes Cell Metastasis of Colorectal Cancer Through PTEN Mediated PI3K/AKT Pathway; The expression of miR-92a PTEN and E-cadherin was analyzed by real-time PCR; In addition there was a negative correlation between levels of miR-92a and the PTEN gene p < 0.0001; The association of levels of miR-92a and PTEN with tumor cell migration in CRC was also confirmed in CRC cell models;MicroRNA miR-92 is overexpressed in a number of tumors and has been proven to negatively regulate a number of tumor suppressor genes including phosphatase and tensin homologue PTEN; PTEN protein expression was decreased in the SiHa cells that were transfected with the miR-92 mimic; The data indicated that miR-92 may increase the migration and invasion of SiHa cells partially through the downregulation of PTEN protein expression;Expression and significance of PTEN and miR 92 in hepatocellular carcinoma; Immunohistochemistry streptavidin-peroxidase SP and quantitative reverse transcriptase-polymerase chain reaction qRT‑PCR were used to detect the expression of PTEN and miR-92 in 15 cases of HCC and the corresponding paracancerous tissues; The correlation between PTEN and miR-92 was analyzed; Additionally the mRNA levels of PTEN and miR-92 showed a significantly negative correlation with each other r=-0.858 P<0.05; In conclusion PTEN and miR-92 have different roles in the development of HCC; The combined detection of PTEN and miR-92 may provide critical clinical evidence for the early diagnosis and prognosis of HCC;PTEN mRNA correlated inversely with miR-92a and members of the miR-17 and miR-130/301 families;The expression levels of miR-92a and phosphatase and tensin homologue PTEN were detected by qRT-PCR and western blot; In addition the regulation of PTEN by miR-92a was evaluated by qRT-PCR western blot and luciferase reporter assays; There was an inverse correlation between the levels of miR-92a and PTEN in CRC tissues; The overexpression of miR-92a in CRC cells decreased PTEN expression at the translational level and decreased PTEN-driven luciferase-reporter activity; Our results demonstrated that miR-92a induced EMT and regulated cell growth migration and invasion in the SW480 cells at least partially via suppression of PTEN expression metastasis;drug resistance;metastasis;cell migration;;worse prognosis;; lung squamous cell cancer;colorectal cancer;cervical and endocervical cancer;liver cancer;sarcoma;colorectal cancer hsa-miR-93-5p PTEN 1.61042951896619 5.1280369606967e-24 -0.105559265617794 0.259478904420102 miRNAWalker2_validate;miRTarBase;miRNATAP -0.189369301529539 1.58326496608035e-15 25633810;26243299;22465665;26087719 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC;microRNA 93 promotes cell proliferation via targeting of PTEN in Osteosarcoma cells; An miRNA miR-93 was significantly up-regulated whereas phosphatase and tensin homologue PTEN expression was significantly down-regulated in all tested OS cells when compared with hMSCs; Ectopic expression of miR-93 decreased PTEN protein levels; Taking these observations together miR-93 can be seen to play a critical role in carcinogenesis through suppression of PTEN and may serve as a therapeutic target for the treatment of OS;Furthermore we found that miR-93 can directly target PTEN and participates in the regulation of the AKT signaling pathway; MiR-93 inversely correlates with PTEN expression in CDDP-resistant and sensitive human ovarian cancer tissues;Furthermore our study found berberine could inhibit miR-93 expression and function in ovarian cancer as shown by an increase of its target PTEN an important tumor suppressor in ovarian cancer; More importantly A2780 cells that were treated with PTEN siRNA had a survival pattern that is similar to cells with miR-93 overexpression ;tumorigenesis;;poor survival liver cancer;sarcoma;ovarian cancer;ovarian cancer hsa-miR-139-5p PTK2 -1.46099200329485 7.85040381494472e-22 0.712163037401015 4.63758818746064e-16 miRanda -0.157882233338886 9.67756748839253e-11 NA NA NA hsa-miR-140-5p PTK2 -0.412389003031485 0.000136051708543369 0.712163037401015 4.63758818746064e-16 miRanda -0.224034101429153 4.18323894722827e-10 NA NA NA hsa-miR-199b-5p PTK2 -1.08432682485992 7.68241801134089e-10 0.712163037401015 4.63758818746064e-16 miRanda -0.136803705433426 2.34749523384687e-10 NA NA NA hsa-miR-382-5p RAC1 -0.512675955239656 0.00311534081639733 0.060247613846359 0.436073210860324 MirTarget -0.110732405915093 6.53593148835981e-09 NA NA NA hsa-miR-17-5p RBL2 1.41924888736771 2.75805544953758e-18 -0.246969867748111 0.01592378348393 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.143700264319262 4.37673737340372e-08 NA NA NA hsa-miR-20a-5p RBL2 1.1531986665452 1.02385132917958e-11 -0.246969867748111 0.01592378348393 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.147438220726723 7.40385047142412e-09 NA NA NA hsa-miR-576-5p RBL2 0.940432050128373 6.90227595663302e-12 -0.246969867748111 0.01592378348393 MirTarget;PITA -0.178415823365207 1.66822901246308e-08 NA NA NA hsa-miR-93-5p RBL2 1.61042951896619 5.1280369606967e-24 -0.246969867748111 0.01592378348393 MirTarget;miRNATAP -0.128261961743392 1.38907217254418e-06 NA NA NA hsa-miR-28-5p RELA -0.026996999089909 0.733047113251652 0.0427844130929831 0.511167069149631 miRanda -0.158597396386128 1.09687495536614e-05 NA NA NA hsa-miR-769-5p RELA 0.0865819375213306 0.445395188017017 0.0427844130929831 0.511167069149631 miRNATAP -0.115778992525935 3.19828405030521e-06 NA NA NA hsa-miR-138-5p RELN 0.702468796115049 0.0082478986123581 -2.33929582246669 1.37967100308948e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.172568739933781 0.00500675933665039 NA NA NA hsa-miR-15a-5p RELN 0.783550182002274 2.60699595655907e-11 -2.33929582246669 1.37967100308948e-11 MirTarget;miRNATAP -0.974075068790958 1.10420092781901e-14 NA NA NA hsa-miR-15b-5p RELN 0.85315666454713 3.79816274836297e-12 -2.33929582246669 1.37967100308948e-11 MirTarget;miRNATAP -0.863691173634498 8.5970412816419e-13 NA NA NA hsa-miR-16-5p RELN 0.521122945828175 1.40561786410572e-06 -2.33929582246669 1.37967100308948e-11 MirTarget;miRNATAP -0.830776806171138 3.28437684047008e-09 NA NA NA hsa-miR-200b-3p RELN 0.0717138787925347 0.682858087587209 -2.33929582246669 1.37967100308948e-11 MirTarget;TargetScan -0.471372969282958 6.04839924355704e-08 NA NA NA hsa-miR-200c-3p RELN 0.630251054099546 0.000131975031451555 -2.33929582246669 1.37967100308948e-11 MirTarget -0.605842444869093 3.42100808851947e-11 NA NA NA hsa-miR-205-5p RELN 1.50759485376634 2.0003886738248e-16 -2.33929582246669 1.37967100308948e-11 miRNATAP -0.747321518737731 1.4536743384343e-21 NA NA NA hsa-miR-224-5p RELN 1.94534596857416 1.88348779207332e-19 -2.33929582246669 1.37967100308948e-11 MirTarget -0.405790981109284 2.23131679514484e-09 NA NA NA hsa-miR-331-5p RELN 0.851618030062133 1.42670149420057e-14 -2.33929582246669 1.37967100308948e-11 MirTarget;miRNATAP -0.629693167182616 3.36073820503987e-06 NA NA NA hsa-miR-34a-5p RELN -0.117372471043915 0.364001947180738 -2.33929582246669 1.37967100308948e-11 miRNATAP -0.669092052349922 1.57482148372158e-08 NA NA NA hsa-miR-34c-5p RELN 0.565896455062849 0.0224052732281715 -2.33929582246669 1.37967100308948e-11 miRanda;miRNATAP -0.163309328294485 0.0085166315220103 NA NA NA hsa-miR-429 RELN 0.559451508722375 0.00563641638673083 -2.33929582246669 1.37967100308948e-11 MirTarget;PITA;miRanda;miRNATAP -0.513607000525342 5.72278482129751e-12 NA NA NA hsa-miR-455-3p RELN 2.68574446868387 4.28975903022818e-42 -2.33929582246669 1.37967100308948e-11 PITA -0.335446398620196 2.42452174553051e-06 NA NA NA hsa-miR-582-5p RELN -0.0366995972742474 0.821827119138923 -2.33929582246669 1.37967100308948e-11 MirTarget;PITA -0.336495006944269 0.000371466893607874 NA NA NA hsa-miR-589-3p RELN 1.59559692667315 6.2886410639161e-15 -2.33929582246669 1.37967100308948e-11 MirTarget -0.463254446186769 7.26636276224856e-10 NA NA NA hsa-miR-590-3p RELN 0.221436901462551 0.0965904764063157 -2.33929582246669 1.37967100308948e-11 miRanda;miRNATAP -0.381375976229945 0.000993022665641581 NA NA NA hsa-miR-744-5p RHEB 0.436098372735845 0.000850400989351181 0.226319699277753 0.00269577315352952 miRNAWalker2_validate -0.100439624808417 5.93644077169242e-05 NA NA NA hsa-miR-744-5p RPS6 0.436098372735845 0.000850400989351181 -0.70252402039163 3.07494562257944e-08 miRNAWalker2_validate -0.177206027999288 3.22590949867249e-05 NA NA NA hsa-miR-181b-5p RPS6KB1 0.974255518824355 2.64876280203475e-16 -0.119108736560683 0.0926638906295523 MirTarget;miRNATAP -0.119633629536219 1.70396937286662e-06 NA NA NA hsa-miR-181d-5p RPS6KB1 0.367649966373544 0.00537300571455306 -0.119108736560683 0.0926638906295523 MirTarget -0.131213437312102 1.20102357516116e-08 NA NA NA hsa-miR-664a-3p RPS6KB1 -0.256108763664991 0.0513188660751664 -0.119108736560683 0.0926638906295523 MirTarget -0.124956709530079 7.38971405939269e-08 NA NA NA hsa-miR-331-3p RPS6KB2 0.906385914819361 4.27653809739414e-11 -0.178930142491454 0.154821414351084 miRNATAP -0.129866487266148 0.000903136770244418 NA NA NA hsa-miR-125a-5p RPTOR 0.215366061934933 0.119550904549401 0.279669551420384 0.00103945813594434 mirMAP -0.107786898931868 6.01583779791539e-05 NA NA NA hsa-miR-125b-5p RPTOR -0.993460109818276 5.07736727659894e-12 0.279669551420384 0.00103945813594434 mirMAP -0.162733773237415 6.90694772472337e-11 NA NA NA hsa-miR-148a-3p RPTOR -0.428944290834563 0.00954246923521465 0.279669551420384 0.00103945813594434 mirMAP -0.120890375295553 5.34398239202687e-08 NA NA NA hsa-miR-218-5p RPTOR -1.0725338636959 3.61493686604269e-09 0.279669551420384 0.00103945813594434 mirMAP -0.101636668930405 3.6726190433211e-07 NA NA NA hsa-miR-34a-5p RPTOR -0.117372471043915 0.364001947180738 0.279669551420384 0.00103945813594434 mirMAP -0.223645211804028 2.00459257846487e-15 NA NA NA hsa-miR-361-3p RPTOR 0.272298288982435 0.0147874880476998 0.279669551420384 0.00103945813594434 MirTarget -0.111031159863074 0.000891701036624779 NA NA NA hsa-miR-125a-3p SGK1 0.116035800853173 0.444825559956959 -0.248104796615564 0.0938017621792925 miRanda -0.22992574613999 4.93817776527835e-08 NA NA NA hsa-miR-299-5p SGK1 -1.92445654064493 1.52402531359074e-16 -0.248104796615564 0.0938017621792925 miRNATAP -0.120629508864858 6.4551660534263e-06 NA NA NA hsa-miR-542-3p SGK1 0.643308814904977 8.81635403230104e-07 -0.248104796615564 0.0938017621792925 miRanda -0.314779674122849 6.43146204615012e-11 NA NA NA hsa-miR-330-5p SGK2 0.944693925383906 5.04972895657346e-13 -1.46861232415014 4.31539756401983e-06 miRanda -0.346399750401988 0.000999426340998432 NA NA NA hsa-miR-542-3p SGK3 0.643308814904977 8.81635403230104e-07 0.0208714104128154 0.841645452965467 miRanda -0.109794562000995 0.001428733136147 NA NA NA hsa-miR-103a-2-5p SOS1 1.37988337975616 6.74852943995612e-08 -0.14430779210223 0.0788675470799712 MirTarget -0.107317494895258 2.70560419461077e-13 NA NA NA hsa-miR-17-5p SOS1 1.41924888736771 2.75805544953758e-18 -0.14430779210223 0.0788675470799712 MirTarget;TargetScan;miRNATAP -0.117731171602632 1.95189099419506e-08 NA NA NA hsa-miR-181a-5p SOS1 0.819060835827404 1.38616688310277e-13 -0.14430779210223 0.0788675470799712 MirTarget;miRNATAP -0.100672350932981 0.00144883651704136 NA NA NA hsa-miR-181b-5p SOS1 0.974255518824355 2.64876280203475e-16 -0.14430779210223 0.0788675470799712 MirTarget;miRNATAP -0.148558703111288 2.95988138178714e-07 NA NA NA hsa-miR-186-5p SOS1 0.353452958261612 0.000145058448579496 -0.14430779210223 0.0788675470799712 MirTarget;mirMAP -0.152552364062524 7.16812353278593e-05 NA NA NA hsa-miR-20a-5p SOS1 1.1531986665452 1.02385132917958e-11 -0.14430779210223 0.0788675470799712 MirTarget;miRNATAP -0.12022910939126 3.57951889599424e-09 NA NA NA hsa-miR-22-5p SOS1 0.706731861922839 3.44318705980007e-07 -0.14430779210223 0.0788675470799712 miRNATAP -0.158730685582191 2.71506892378126e-10 NA NA NA hsa-miR-30b-5p SOS1 -0.400238605368173 0.00346540992719245 -0.14430779210223 0.0788675470799712 mirMAP -0.126352161603185 1.03698542764349e-06 NA NA NA hsa-miR-30c-5p SOS1 0.021222006155897 0.886366656528128 -0.14430779210223 0.0788675470799712 mirMAP;miRNATAP -0.135903886215057 1.16781024741833e-08 NA NA NA hsa-miR-339-5p SOS1 1.07771430326938 2.45772601859307e-09 -0.14430779210223 0.0788675470799712 miRNATAP -0.128892301297403 1.48838832376727e-11 NA NA NA hsa-miR-365a-3p SOS1 0.446833934952926 0.00233857759218299 -0.14430779210223 0.0788675470799712 miRNATAP -0.1783566963117 5.57885493367077e-14 NA NA NA hsa-miR-576-5p SOS1 0.940432050128373 6.90227595663302e-12 -0.14430779210223 0.0788675470799712 mirMAP -0.137121069751198 5.95871216796928e-08 NA NA NA hsa-miR-590-5p SOS1 0.763025362395968 3.65305892505623e-09 -0.14430779210223 0.0788675470799712 miRanda -0.102087263279598 0.000173697009124336 NA NA NA hsa-miR-130a-3p SOS2 0.67051191119964 4.89747518735144e-06 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.142452400506012 9.1977279101434e-07 NA NA NA hsa-miR-130b-3p SOS2 1.44628430084411 9.13980959861273e-24 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.166141799618233 4.74896683998837e-09 NA NA NA hsa-miR-140-5p SOS2 -0.412389003031485 0.000136051708543369 -0.413855174319239 2.70724213132607e-05 miRanda -0.115984900471818 0.00375469960502604 NA NA NA hsa-miR-146b-5p SOS2 0.917975986853978 3.33749259316025e-09 -0.413855174319239 2.70724213132607e-05 miRanda -0.148988622111336 4.132997452968e-08 NA NA NA hsa-miR-15a-5p SOS2 0.783550182002274 2.60699595655907e-11 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.246192745452679 4.355188886614e-12 NA NA NA hsa-miR-15b-5p SOS2 0.85315666454713 3.79816274836297e-12 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.183474265512814 8.3295370014568e-08 NA NA NA hsa-miR-16-5p SOS2 0.521122945828175 1.40561786410572e-06 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.154096465704255 0.000106046501996405 NA NA NA hsa-miR-21-5p SOS2 1.62465922021121 3.44191300985109e-58 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.19831212276022 1.74180372845288e-07 NA NA NA hsa-miR-301a-3p SOS2 2.14132004241926 4.46255413526808e-25 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.120432560927103 7.67307961625067e-10 NA NA NA hsa-miR-320a SOS2 0.801356001806321 4.91397101474502e-09 -0.413855174319239 2.70724213132607e-05 miRanda;miRNATAP -0.180058190704833 4.89057631979479e-09 NA NA NA hsa-miR-454-3p SOS2 1.54137391927201 4.15861570449376e-20 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.189860305441434 3.92270128753751e-15 NA NA NA hsa-miR-590-3p SOS2 0.221436901462551 0.0965904764063157 -0.413855174319239 2.70724213132607e-05 miRanda;mirMAP -0.11728383435213 0.000301105591653965 NA NA NA hsa-miR-590-5p SOS2 0.763025362395968 3.65305892505623e-09 -0.413855174319239 2.70724213132607e-05 PITA;miRanda;miRNATAP -0.141487335002342 1.65802166639907e-05 NA NA NA hsa-miR-139-5p SPP1 -1.46099200329485 7.85040381494472e-22 3.13698287810329 2.52711273098143e-16 miRanda -0.982468197986807 5.945578026932e-21 NA NA NA hsa-miR-335-5p SPP1 -1.17227779671552 1.49282618530733e-10 3.13698287810329 2.52711273098143e-16 miRNAWalker2_validate -0.297441724953532 0.00126731967128808 NA NA NA hsa-miR-362-3p SPP1 -0.697212068252854 2.61718493418184e-06 3.13698287810329 2.52711273098143e-16 miRanda -0.503490269497998 1.20718234999541e-05 NA NA NA hsa-miR-127-5p SYK -0.605739525751187 0.000636065602565634 -0.0225396514105407 0.881756918918741 mirMAP -0.139876827835151 0.000151788262668687 NA NA NA hsa-miR-877-5p SYK 1.97571572671705 2.0032239372269e-19 -0.0225396514105407 0.881756918918741 mirMAP -0.121863987983432 9.25581262835513e-05 NA NA NA hsa-miR-99b-3p SYK 0.719990421486748 1.67776350671332e-07 -0.0225396514105407 0.881756918918741 miRNAWalker2_validate -0.269990835492604 8.79511410095149e-09 NA NA NA hsa-miR-455-5p TEK 1.408595672323 5.52039116456697e-22 -0.811440710527928 5.69194413665357e-05 miRanda -0.425414566026056 7.03195605940042e-14 NA NA NA hsa-miR-127-3p TGFA -1.47175957435172 9.8707469067377e-14 0.471727986880251 0.0113818927785784 miRanda -0.141382459165978 0.000414490089130158 NA NA NA hsa-miR-140-3p TGFA -0.967453553824782 7.6999446305445e-23 0.471727986880251 0.0113818927785784 miRNATAP -0.467811848334099 2.99965838244465e-09 NA NA NA hsa-miR-148a-3p TGFA -0.428944290834563 0.00954246923521465 0.471727986880251 0.0113818927785784 miRNATAP -0.295663414803172 1.05042629234724e-09 NA NA NA hsa-miR-181c-5p TGFA -0.168991199007857 0.196949106150297 0.471727986880251 0.0113818927785784 mirMAP -0.448953172504114 1.94673209653859e-13 NA NA NA hsa-miR-199a-5p TGFA -0.364835768178638 0.0435119211101981 0.471727986880251 0.0113818927785784 miRNATAP -0.227002907986154 3.66131696673185e-07 NA NA NA hsa-miR-199b-5p TGFA -1.08432682485992 7.68241801134089e-10 0.471727986880251 0.0113818927785784 miRNATAP -0.135537208331098 0.00283719224643909 NA NA NA hsa-miR-23b-3p TGFA -0.497563803223134 3.31483353357535e-05 0.471727986880251 0.0113818927785784 miRNATAP -0.223744977100315 0.000947483091760639 NA NA NA hsa-miR-28-5p TGFA -0.026996999089909 0.733047113251652 0.471727986880251 0.0113818927785784 miRanda -0.716739492778532 3.02236769253326e-12 NA NA NA hsa-miR-29b-2-5p TGFA -0.502720326849742 0.000730448246894952 0.471727986880251 0.0113818927785784 mirMAP -0.26552490768259 9.45493554660137e-07 NA NA NA hsa-miR-335-3p TGFA 0.336785882180547 0.0542446207938138 0.471727986880251 0.0113818927785784 mirMAP -0.151211914058655 0.00113553869536674 NA NA NA hsa-miR-342-3p TGFA 0.99756868977753 9.28499866272332e-10 0.471727986880251 0.0113818927785784 miRanda -0.155245570093664 0.00157925124207155 NA NA NA hsa-miR-491-5p TGFA -0.541680329196715 0.00135829217561865 0.471727986880251 0.0113818927785784 miRanda -0.270228376430328 5.5689748399773e-08 NA NA NA hsa-miR-495-3p TGFA -1.47803501311999 6.88839745293927e-13 0.471727986880251 0.0113818927785784 mirMAP -0.148801898062084 0.000116065245602931 NA NA NA hsa-let-7a-3p THBS1 0.0966652362351867 0.423761916840503 -0.0602688709574686 0.817102472377875 mirMAP -0.257626055880682 0.00641628779702676 NA NA NA hsa-miR-155-5p THBS1 0.533437622040649 0.00248671179205372 -0.0602688709574686 0.817102472377875 miRNAWalker2_validate;mirMAP -0.17476722608862 0.006488079922108 NA NA NA hsa-miR-16-1-3p THBS1 0.955017760172879 5.95379292601146e-11 -0.0602688709574686 0.817102472377875 MirTarget -0.500955283959431 2.92731476405759e-11 NA NA NA hsa-miR-17-5p THBS1 1.41924888736771 2.75805544953758e-18 -0.0602688709574686 0.817102472377875 miRNAWalker2_validate -0.381344928892176 1.05498288528831e-08 NA NA NA hsa-miR-181c-5p THBS1 -0.168991199007857 0.196949106150297 -0.0602688709574686 0.817102472377875 mirMAP -0.247983674823625 0.00437646006301906 NA NA NA hsa-miR-182-5p THBS1 1.15060905311096 6.25565852529946e-10 -0.0602688709574686 0.817102472377875 MirTarget -0.309873212711269 1.84640622484898e-07 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-18a-5p THBS1 1.65455873230328 3.76457892277775e-20 -0.0602688709574686 0.817102472377875 MirTarget -0.24726989244349 4.30044680655473e-05 NA NA NA hsa-miR-19a-3p THBS1 1.35800152353624 2.80940447111944e-12 -0.0602688709574686 0.817102472377875 MirTarget;mirMAP -0.414578771692538 1.14486667604464e-13 NA NA NA hsa-miR-19b-3p THBS1 0.538732279378089 0.000622008277870679 -0.0602688709574686 0.817102472377875 MirTarget;mirMAP -0.579635022619252 1.04471069287289e-16 NA NA NA hsa-miR-200a-5p THBS1 0.701063526850019 0.000188402923774663 -0.0602688709574686 0.817102472377875 MirTarget -0.493887203406803 2.53713541729748e-17 NA NA NA hsa-miR-200b-5p THBS1 0.02621402664548 0.883725338810228 -0.0602688709574686 0.817102472377875 MirTarget -0.429279995414032 5.28189107350755e-12 NA NA NA hsa-miR-20a-5p THBS1 1.1531986665452 1.02385132917958e-11 -0.0602688709574686 0.817102472377875 miRNAWalker2_validate -0.475131098210825 1.34284170648631e-13 NA NA NA hsa-miR-32-5p THBS1 -0.317310201890053 0.0102525324475293 -0.0602688709574686 0.817102472377875 mirMAP -0.348384610454154 0.00014766125359508 NA NA NA hsa-miR-33a-3p THBS1 0.20371038027126 0.212335697664505 -0.0602688709574686 0.817102472377875 MirTarget;mirMAP -0.397919916365233 1.19875077545057e-08 NA NA NA hsa-miR-500a-5p THBS1 0.675401699376111 8.24389004707854e-05 -0.0602688709574686 0.817102472377875 mirMAP -0.36725155536225 1.649731351533e-08 NA NA NA hsa-miR-576-5p THBS1 0.940432050128373 6.90227595663302e-12 -0.0602688709574686 0.817102472377875 mirMAP -0.255507850086054 0.00165862768717641 NA NA NA hsa-miR-589-3p THBS1 1.59559692667315 6.2886410639161e-15 -0.0602688709574686 0.817102472377875 mirMAP -0.170472312541131 0.0024064977779302 NA NA NA hsa-miR-590-5p THBS1 0.763025362395968 3.65305892505623e-09 -0.0602688709574686 0.817102472377875 miRanda;mirMAP -0.520750608832199 1.15560113303924e-09 NA NA NA hsa-miR-629-3p THBS1 1.43262037314105 2.37092217984413e-19 -0.0602688709574686 0.817102472377875 MirTarget -0.264076289477301 0.00011856285955883 NA NA NA hsa-miR-664a-3p THBS1 -0.256108763664991 0.0513188660751664 -0.0602688709574686 0.817102472377875 mirMAP -0.396960198069835 4.00846362134978e-06 NA NA NA hsa-miR-7-1-3p THBS1 1.13646121619622 1.49823237535933e-14 -0.0602688709574686 0.817102472377875 MirTarget;mirMAP -0.403917251404343 5.0859524726101e-08 NA NA NA hsa-miR-92a-3p THBS1 0.994679542307232 1.32587679156217e-16 -0.0602688709574686 0.817102472377875 miRNAWalker2_validate -0.672834298334846 7.04881253821255e-14 NA NA NA hsa-miR-106a-5p THBS2 0.67978010057847 0.00221925869726092 1.62618248595017 5.83385949124459e-09 MirTarget -0.498038651519378 1.0423338841424e-20 NA NA NA hsa-miR-106b-5p THBS2 0.50378717276868 1.45412404526866e-05 1.62618248595017 5.83385949124459e-09 MirTarget -0.520299545803915 7.89973482462783e-07 NA NA NA hsa-miR-142-5p THBS2 0.288897753038094 0.0900009317815725 1.62618248595017 5.83385949124459e-09 mirMAP -0.286021179500209 7.68382546528818e-05 NA NA NA hsa-miR-16-2-3p THBS2 1.1567130855258 1.01867256952189e-14 1.62618248595017 5.83385949124459e-09 mirMAP -0.695934931312402 4.38390463808463e-19 NA NA NA hsa-miR-17-5p THBS2 1.41924888736771 2.75805544953758e-18 1.62618248595017 5.83385949124459e-09 MirTarget;TargetScan -0.386282137212615 1.10388771192053e-07 NA NA NA hsa-miR-20a-5p THBS2 1.1531986665452 1.02385132917958e-11 1.62618248595017 5.83385949124459e-09 MirTarget -0.441807863444289 3.56122890496723e-10 NA NA NA hsa-miR-20b-5p THBS2 0.345967670847176 0.232014828043601 1.62618248595017 5.83385949124459e-09 MirTarget -0.386757637243133 4.89685171657703e-21 NA NA NA hsa-miR-29a-3p THBS2 -1.26881270980079 2.82496991513463e-22 1.62618248595017 5.83385949124459e-09 MirTarget -0.375971052620663 3.27406128446898e-05 NA NA NA hsa-miR-29b-3p THBS2 -0.110721443686039 0.511264554091106 1.62618248595017 5.83385949124459e-09 MirTarget -0.604035666487595 2.42231935501019e-17 NA NA NA hsa-miR-29c-3p THBS2 -2.08166260448948 8.3238369390898e-24 1.62618248595017 5.83385949124459e-09 MirTarget -0.383432822523996 7.31542489520432e-12 NA NA NA hsa-miR-320a THBS2 0.801356001806321 4.91397101474502e-09 1.62618248595017 5.83385949124459e-09 mirMAP -0.333738172381151 0.000174825842344476 NA NA NA hsa-miR-320b THBS2 1.23473838180754 3.04337566045537e-14 1.62618248595017 5.83385949124459e-09 mirMAP -0.253915498040408 0.000606797171209941 NA NA NA hsa-miR-335-3p THBS2 0.336785882180547 0.0542446207938138 1.62618248595017 5.83385949124459e-09 MirTarget;mirMAP -0.205075913442286 0.00369881790334179 NA NA NA hsa-miR-582-3p THBS2 -0.248056267546012 0.143798829508405 1.62618248595017 5.83385949124459e-09 miRNATAP -0.614582447701426 3.28736839956178e-18 NA NA NA hsa-miR-590-3p THBS2 0.221436901462551 0.0965904764063157 1.62618248595017 5.83385949124459e-09 miRanda;mirMAP -0.490631194415479 1.03044076631118e-07 NA NA NA hsa-miR-590-5p THBS2 0.763025362395968 3.65305892505623e-09 1.62618248595017 5.83385949124459e-09 miRanda -0.606004824335812 7.10608278095606e-11 NA NA NA hsa-miR-598-3p THBS2 -0.501551607314861 0.00273752172874978 1.62618248595017 5.83385949124459e-09 MirTarget -0.247403867800378 0.000771969489446281 NA NA NA hsa-miR-7-1-3p THBS2 1.13646121619622 1.49823237535933e-14 1.62618248595017 5.83385949124459e-09 MirTarget;mirMAP -0.49189242601595 9.78785576248441e-10 NA NA NA hsa-miR-9-5p THBS2 1.65694862043766 2.08325802567323e-05 1.62618248595017 5.83385949124459e-09 miRNATAP -0.189182675409391 1.04224055895548e-09 NA NA NA hsa-miR-93-5p THBS2 1.61042951896619 5.1280369606967e-24 1.62618248595017 5.83385949124459e-09 MirTarget -0.32493483850462 1.05176746904084e-05 NA NA NA hsa-miR-96-5p THBS2 1.42326703011157 4.39736150032373e-14 1.62618248595017 5.83385949124459e-09 TargetScan;miRNATAP -0.223958633163457 0.000445050719007805 NA NA NA hsa-miR-142-3p THBS4 1.12754191614028 1.68798138028946e-08 -1.40679456025273 0.00305436232912916 miRanda -0.264871491171797 0.00978426912368451 NA NA NA hsa-miR-320b THBS4 1.23473838180754 3.04337566045537e-14 -1.40679456025273 0.00305436232912916 miRanda -0.444842228904128 0.000348466198155946 NA NA NA hsa-miR-19b-3p TLR2 0.538732279378089 0.000622008277870679 0.680390591356542 8.79424129241448e-05 miRNAWalker2_validate;miRTarBase -0.144029181467728 0.00278386026993084 NA NA NA hsa-miR-335-5p TLR2 -1.17227779671552 1.49282618530733e-10 0.680390591356542 8.79424129241448e-05 miRNAWalker2_validate -0.135167875099107 0.000914790151895636 NA NA NA hsa-miR-17-5p TLR4 1.41924888736771 2.75805544953758e-18 -0.683404144500101 0.00115797658551998 TargetScan -0.58694776323337 6.77808927329476e-30 NA NA NA hsa-miR-331-5p TLR4 0.851618030062133 1.42670149420057e-14 -0.683404144500101 0.00115797658551998 MirTarget -0.400979411219465 7.06480819460915e-07 NA NA NA hsa-miR-34c-5p TLR4 0.565896455062849 0.0224052732281715 -0.683404144500101 0.00115797658551998 miRanda -0.113721373084139 0.00214419196950869 NA NA NA hsa-miR-590-5p TLR4 0.763025362395968 3.65305892505623e-09 -0.683404144500101 0.00115797658551998 miRanda -0.534348724226681 6.88133433226738e-15 NA NA NA hsa-miR-7-1-3p TLR4 1.13646121619622 1.49823237535933e-14 -0.683404144500101 0.00115797658551998 mirMAP -0.209742015287372 0.000542111591606728 NA NA NA hsa-miR-944 TLR4 1.47323925060177 2.61626403984929e-13 -0.683404144500101 0.00115797658551998 miRNATAP -0.255848440805719 6.25261406583618e-09 NA NA NA hsa-miR-126-5p TNC -0.953529188793816 7.91719143295591e-16 1.86114864094287 6.8600650455825e-11 miRNATAP -0.2840974784557 0.00659749428791764 NA NA NA hsa-miR-335-5p TNC -1.17227779671552 1.49282618530733e-10 1.86114864094287 6.8600650455825e-11 miRNAWalker2_validate;miRTarBase -0.206395559501656 0.00240544523157137 NA NA NA hsa-miR-9-5p TNC 1.65694862043766 2.08325802567323e-05 1.86114864094287 6.8600650455825e-11 MirTarget;miRNATAP -0.23822061428961 3.88765669970334e-14 NA NA NA hsa-miR-944 TNN 1.47323925060177 2.61626403984929e-13 0.11277408791798 0.731630447786543 miRNATAP -0.236526746646716 0.000636831455604959 NA NA NA hsa-miR-1301-3p TNXB 2.13677668481885 6.11093268540831e-44 -3.07772378362824 4.32929076766859e-27 miRNAWalker2_validate -0.588240725344388 1.44201344635281e-14 NA NA NA hsa-miR-3607-3p TNXB 1.01377165357363 9.13355519701165e-05 -3.07772378362824 4.32929076766859e-27 miRNATAP -0.222614345546366 8.70123576736694e-06 NA NA NA hsa-miR-27a-3p TP53 0.348456440505425 0.00126682892514312 -0.41755807197951 0.03001853518726 miRNAWalker2_validate -0.202518579356515 0.009421402460679 NA NA NA hsa-miR-101-3p VEGFA -1.91263766544878 1.50270129259053e-39 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate -0.281477062331858 8.81075776241686e-11 NA NA NA hsa-miR-134-5p VEGFA -0.598302069876985 0.00124773585997939 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.114375387301794 0.00210306889630562 NA NA NA hsa-miR-140-5p VEGFA -0.412389003031485 0.000136051708543369 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.268410061738275 2.63838447575462e-05 26402430 MicroRNA 140 5p inhibits the progression of colorectal cancer by targeting VEGFA; The direct regulation of VEGFA by miR-140-5p was identified using luciferase reporter assay; Integrated analysis identified VEGFA as a direct and functional target gene of miR-140-5p; Silencing VEGFA by small interfering RNA siRNA resembled the phenotype resulting from ectopic miR-140-5p expression while overexpression of VEGFA attenuated the effect of miR-140-5p on CRC cells; Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA progression;tumorigenesis colorectal cancer hsa-miR-150-5p VEGFA -0.243749814009231 0.331546276920338 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase -0.1837154779422 1.13782348414927e-11 NA NA NA hsa-miR-195-5p VEGFA -1.8367376818177 6.9944883988895e-31 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.266371206927854 4.016968187035e-11 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199b-5p VEGFA -1.08432682485992 7.68241801134089e-10 0.873514320132464 2.52351953389146e-08 miRanda -0.107087744674295 0.00559641745284255 NA NA NA hsa-miR-29a-3p VEGFA -1.26881270980079 2.82496991513463e-22 0.873514320132464 2.52351953389146e-08 MirTarget -0.288406509783812 9.95429090012523e-09 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29c-3p VEGFA -2.08166260448948 8.3238369390898e-24 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;MirTarget -0.194088476141854 6.98364039221839e-10 NA NA NA hsa-miR-374a-5p VEGFA -0.621903385111545 6.61791773205282e-12 0.873514320132464 2.52351953389146e-08 MirTarget -0.350545644085801 3.16629895028707e-06 23679262 Our data demonstrated miR-374a to be differentially distributed in breast cancer; VEGF-A and VCAM-1 mRNA had coincident distribution and the distribution of teh respective proteins was uneven and opposite to that for the miR-374a breast cancer hsa-miR-378a-3p VEGFA -1.50453783521372 9.41694954361173e-17 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase -0.103722847977571 0.00515698881281656 NA NA NA hsa-miR-128-3p VEGFC -0.170677254601174 0.20412808476528 1.21496433527706 2.56999707057218e-05 miRNAWalker2_validate;MirTarget -0.344606861179054 0.000264644189549296 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-129-5p VEGFC -0.246329588499478 0.436451191224681 1.21496433527706 2.56999707057218e-05 miRanda -0.181674391970532 6.89957949062694e-06 NA NA NA hsa-miR-16-2-3p VEGFC 1.1567130855258 1.01867256952189e-14 1.21496433527706 2.56999707057218e-05 MirTarget -0.264631968748485 0.00136032612419468 NA NA NA hsa-miR-27b-3p VEGFC -0.732682718863563 2.26896143573324e-09 1.21496433527706 2.56999707057218e-05 MirTarget -1.03529262957351 2.14560495828989e-26 23593282 We identified vascular endothelial growth factor C VEGFC as a novel target gene of miR-27b and determined that miR-27b functioned as an inhibitor of tumor progression and angiogenesis through targeting VEGFC in CRC; In summary an anti-tumor role for miR-27b and its novel target VEGFC in vivo could lead to tumor necrosis and provide a rationale for developing miR-27b as a therapeutic agent progression colorectal cancer hsa-miR-374a-5p VEGFC -0.621903385111545 6.61791773205282e-12 1.21496433527706 2.56999707057218e-05 MirTarget -0.421266396238901 0.00236790056229042 NA NA NA hsa-miR-15a-5p VWF 0.783550182002274 2.60699595655907e-11 -0.463849763752713 0.00467175466261172 mirMAP -0.362055068219269 9.93524632953833e-10 NA NA NA hsa-miR-15b-5p VWF 0.85315666454713 3.79816274836297e-12 -0.463849763752713 0.00467175466261172 mirMAP -0.215115421642337 0.000167726739771914 NA NA NA hsa-miR-16-5p VWF 0.521122945828175 1.40561786410572e-06 -0.463849763752713 0.00467175466261172 mirMAP -0.253164600396341 0.000123183540123772 NA NA NA hsa-miR-424-5p VWF 1.48125289532143 9.10372985713165e-19 -0.463849763752713 0.00467175466261172 mirMAP -0.191266715715746 3.16583520909317e-06 NA NA NA hsa-miR-429 VWF 0.559451508722375 0.00563641638673083 -0.463849763752713 0.00467175466261172 miRNATAP -0.244611805004923 1.66220056901911e-12 NA NA NA hsa-miR-181c-5p YWHAB -0.168991199007857 0.196949106150297 0.00881901233011639 0.898873897369249 mirMAP -0.162599760897484 5.80022917244678e-13 NA NA NA hsa-miR-218-5p YWHAB -1.0725338636959 3.61493686604269e-09 0.00881901233011639 0.898873897369249 MirTarget;miRNATAP -0.129695867674064 2.61732110074287e-16 NA NA NA hsa-miR-28-3p YWHAB 0.459875450032895 3.47095927872566e-07 0.00881901233011639 0.898873897369249 mirMAP -0.121898698299706 0.000245458193878681 NA NA NA hsa-miR-26a-5p YWHAE -1.09269574587169 1.24020612216319e-22 -0.011693142597748 0.858085854108992 miRNAWalker2_validate;miRNATAP -0.134851355513539 2.34107313476958e-08 NA NA NA hsa-miR-30e-3p YWHAE -0.890635378639789 1.65740480611339e-16 -0.011693142597748 0.858085854108992 miRNAWalker2_validate;MirTarget -0.122782409777311 1.32307601654417e-06 NA NA NA hsa-miR-140-3p YWHAG -0.967453553824782 7.6999446305445e-23 0.330299865053775 0.000136511662733804 MirTarget;PITA;miRNATAP -0.103358457091299 0.00540157523681645 NA NA NA hsa-miR-148a-3p YWHAG -0.428944290834563 0.00954246923521465 0.330299865053775 0.000136511662733804 mirMAP -0.172562576929802 9.80841062387561e-15 NA NA NA hsa-miR-148b-3p YWHAG 0.386859166050437 4.6728211830726e-06 0.330299865053775 0.000136511662733804 mirMAP -0.127068459520355 0.00478750444470103 NA NA NA hsa-miR-181c-5p YWHAG -0.168991199007857 0.196949106150297 0.330299865053775 0.000136511662733804 MirTarget;miRNATAP -0.179801848435716 3.17700531037192e-10 NA NA NA hsa-miR-186-5p YWHAG 0.353452958261612 0.000145058448579496 0.330299865053775 0.000136511662733804 mirMAP -0.148835514391217 0.000264572338061396 NA NA NA hsa-miR-200a-3p YWHAG 0.607140814457753 0.00289840524858752 0.330299865053775 0.000136511662733804 MirTarget;miRNATAP -0.109714904319702 1.84079025598854e-09 NA NA NA hsa-miR-200b-3p YWHAG 0.0717138787925347 0.682858087587209 0.330299865053775 0.000136511662733804 MirTarget;TargetScan -0.119044631431967 2.4988893127847e-08 NA NA NA hsa-miR-30a-5p YWHAG -1.79779915425811 1.93360169837799e-26 0.330299865053775 0.000136511662733804 miRNATAP -0.146711637270905 2.05639265713117e-12 NA NA NA hsa-miR-30b-5p YWHAG -0.400238605368173 0.00346540992719245 0.330299865053775 0.000136511662733804 miRNATAP -0.157165643805315 8.77435645310602e-09 NA NA NA hsa-miR-30c-5p YWHAG 0.021222006155897 0.886366656528128 0.330299865053775 0.000136511662733804 miRNATAP -0.175640843750997 2.47764574936125e-12 NA NA NA hsa-miR-30d-5p YWHAG -0.38399848121878 0.000171129616944749 0.330299865053775 0.000136511662733804 miRNATAP -0.150426546243279 4.79824419705503e-05 NA NA NA hsa-miR-30e-5p YWHAG -1.02114836019762 6.81961221797866e-17 0.330299865053775 0.000136511662733804 miRNATAP -0.238931774160398 3.47283564025138e-16 NA NA NA hsa-miR-320a YWHAG 0.801356001806321 4.91397101474502e-09 0.330299865053775 0.000136511662733804 PITA;miRanda;miRNATAP -0.109092478160448 6.02904259165254e-05 NA NA NA hsa-miR-342-3p YWHAG 0.99756868977753 9.28499866272332e-10 0.330299865053775 0.000136511662733804 miRanda -0.129680704448062 9.51810845665504e-09 NA NA NA hsa-miR-361-3p YWHAG 0.272298288982435 0.0147874880476998 0.330299865053775 0.000136511662733804 miRNATAP -0.215264671621153 1.33485624045165e-10 NA NA NA hsa-miR-625-3p YWHAG 0.0858338965684338 0.484971431380441 0.330299865053775 0.000136511662733804 MirTarget -0.17427169354784 1.24901421052461e-08 NA NA NA hsa-miR-361-5p YWHAH 0.0803683277369505 0.314043140368058 0.606590747915194 2.2258270392452e-20 miRanda -0.143754438817592 0.000129662085983515 NA NA NA hsa-miR-140-5p YWHAQ -0.412389003031485 0.000136051708543369 0.297188016762384 0.000301717728960227 miRanda -0.144369110796683 1.28394289726585e-05 NA NA NA hsa-miR-320a YWHAQ 0.801356001806321 4.91397101474502e-09 0.297188016762384 0.000301717728960227 MirTarget;PITA;miRanda;miRNATAP -0.122791197390879 1.79476954628365e-06 NA NA NA hsa-miR-328-3p YWHAQ 0.153404163477345 0.292356842798574 0.297188016762384 0.000301717728960227 miRNAWalker2_validate -0.14067106382548 8.41883816895344e-09 NA NA NA hsa-miR-497-5p YWHAQ -0.966244470847844 5.26505649147857e-12 0.297188016762384 0.000301717728960227 MirTarget;miRNATAP -0.160727522583736 8.39459490325181e-11 NA NA NA hsa-miR-125a-5p YWHAZ 0.215366061934933 0.119550904549401 0.344806894705046 0.00159832448868044 miRanda -0.131737820968702 0.000133229843462919 NA NA NA hsa-miR-140-3p YWHAZ -0.967453553824782 7.6999446305445e-23 0.344806894705046 0.00159832448868044 MirTarget;PITA;miRNATAP -0.332612441544844 4.02857377845901e-13 NA NA NA hsa-miR-195-3p YWHAZ -0.624259620429699 0.000164279659144497 0.344806894705046 0.00159832448868044 MirTarget -0.179161299851689 2.75832505706067e-10 NA NA NA hsa-miR-217 YWHAZ -1.35391381055929 2.42394951427902e-09 0.344806894705046 0.00159832448868044 miRanda -0.115379904046822 1.65379610658317e-08 NA NA NA hsa-miR-28-5p YWHAZ -0.026996999089909 0.733047113251652 0.344806894705046 0.00159832448868044 PITA;miRanda;miRNATAP -0.460593947828525 1.51249556078375e-14 NA NA NA hsa-miR-30a-5p YWHAZ -1.79779915425811 1.93360169837799e-26 0.344806894705046 0.00159832448868044 miRNAWalker2_validate;MirTarget;miRNATAP -0.257456100150205 1.20682025865332e-23 NA NA NA hsa-miR-30b-5p YWHAZ -0.400238605368173 0.00346540992719245 0.344806894705046 0.00159832448868044 MirTarget;miRNATAP -0.134959972136251 0.000102257748497268 NA NA NA hsa-miR-30c-5p YWHAZ 0.021222006155897 0.886366656528128 0.344806894705046 0.00159832448868044 MirTarget;miRNATAP -0.158375500764273 7.34079247818284e-07 24519092 Involvement of miR 30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells; Together our findings provided evidence that miR-30c was one of the important miRNAs in doxorubicin resistance by regulating YWHAZ in the breast cancer cell line MCF-7/ADR drug resistance breast cancer hsa-miR-30d-5p YWHAZ -0.38399848121878 0.000171129616944749 0.344806894705046 0.00159832448868044 MirTarget;miRNATAP -0.182363700762594 9.34714131398731e-05 NA NA NA hsa-miR-30e-5p YWHAZ -1.02114836019762 6.81961221797866e-17 0.344806894705046 0.00159832448868044 MirTarget;miRNATAP -0.287219608655415 8.9471584773708e-15 NA NA NA hsa-miR-320a YWHAZ 0.801356001806321 4.91397101474502e-09 0.344806894705046 0.00159832448868044 MirTarget;PITA;miRanda;miRNATAP -0.174562705304479 3.1139990151526e-07 NA NA NA hsa-miR-320b YWHAZ 1.23473838180754 3.04337566045537e-14 0.344806894705046 0.00159832448868044 MirTarget;PITA;miRanda;miRNATAP -0.1345921734285 2.20431003170386e-06 NA NA NA hsa-miR-328-3p YWHAZ 0.153404163477345 0.292356842798574 0.344806894705046 0.00159832448868044 MirTarget -0.158722107237606 1.12570217375833e-06 NA NA NA hsa-miR-335-3p YWHAZ 0.336785882180547 0.0542446207938138 0.344806894705046 0.00159832448868044 mirMAP -0.137412436277824 3.72360558086778e-07 NA NA NA hsa-miR-340-3p YWHAZ 0.289340144425255 0.0371281333347226 0.344806894705046 0.00159832448868044 miRNAWalker2_validate -0.13819894036917 5.61930086606928e-05 NA NA NA hsa-miR-374a-3p YWHAZ -0.299190081500425 0.00682975596757891 0.344806894705046 0.00159832448868044 mirMAP -0.235356330221876 4.04380116686581e-08 NA NA NA hsa-miR-378a-3p YWHAZ -1.50453783521372 9.41694954361173e-17 0.344806894705046 0.00159832448868044 miRNAWalker2_validate -0.138587190642273 4.20943927356468e-08 NA NA NA hsa-miR-3913-5p YWHAZ 0.48532077857571 0.00112373589405304 0.344806894705046 0.00159832448868044 MirTarget -0.119371212598511 0.000192155941997275 NA NA NA hsa-miR-423-5p YWHAZ 0.60141781325829 1.62940950644999e-07 0.344806894705046 0.00159832448868044 miRNAWalker2_validate -0.144999889763823 0.000434990684154854 NA NA NA hsa-miR-582-3p YWHAZ -0.248056267546012 0.143798829508405 0.344806894705046 0.00159832448868044 miRNATAP -0.14176604788771 3.76616387478394e-07 NA NA NA hsa-miR-582-5p YWHAZ -0.0366995972742474 0.821827119138923 0.344806894705046 0.00159832448868044 PITA -0.134128132346311 4.23230737234185e-06 NA NA NA hsa-miR-664a-3p YWHAZ -0.256108763664991 0.0513188660751664 0.344806894705046 0.00159832448868044 mirMAP -0.166079540885946 4.4590256821311e-06 NA NA NA