miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-196b-5p A2ML1 4.51951031652328 7.04026169031626e-18 -0.940983423029093 0.154900343191622 MirTarget -0.161701814263372 0.0248545504699685 NA NA NA hsa-miR-146b-5p AASS 2.23105707690238 3.83997814011313e-23 -0.79386674202906 0.000125530137556845 miRanda -0.262462155005947 3.07316334238945e-07 NA NA NA hsa-miR-183-5p ABAT 2.08412478942637 1.08931431254487e-10 -1.26918227153372 2.40251131764188e-07 MirTarget -0.138866324071899 0.00238757514334005 NA NA NA hsa-miR-21-5p ABAT 2.21515015440792 6.0468197386674e-49 -1.26918227153372 2.40251131764188e-07 MirTarget -0.343703044289344 4.90456414950861e-05 NA NA NA hsa-miR-135b-5p ABCA1 2.80066701698235 2.12546333413447e-11 0.607204161288785 0.000197686022710701 MirTarget -0.110266007065811 3.82579630603959e-06 NA NA NA hsa-miR-183-5p ABCA1 2.08412478942637 1.08931431254487e-10 0.607204161288785 0.000197686022710701 MirTarget;miRNATAP -0.168890245497876 8.02272672411616e-09 26935154 MiR 183 functions as an oncogene by targeting ABCA1 in colon cancer; We found that miR-183 targets the 3'UTR of ABCA1 mRNA; Subsequent experiments confirmed that miR-183 degraded ABCA1 mRNA in the colon cancer cells; Thus we conclude that miR-183 promotes proliferation and inhibits apoptosis by degrading ABCA1 in colon cancer colon cancer hsa-miR-200a-3p ABCA1 2.02394729844446 2.21240501925011e-08 0.607204161288785 0.000197686022710701 mirMAP -0.163117422979513 5.0186029939335e-10 NA NA NA hsa-miR-200b-3p ABCA1 2.06025765178663 3.07718049337497e-10 0.607204161288785 0.000197686022710701 TargetScan -0.163863464161358 1.5547472437985e-08 NA NA NA hsa-miR-200b-3p ABCA10 2.06025765178663 3.07718049337497e-10 -0.571454955019528 0.0367378237971729 mirMAP -0.283943018746163 3.60303647867075e-09 NA NA NA hsa-miR-21-5p ABCA10 2.21515015440792 6.0468197386674e-49 -0.571454955019528 0.0367378237971729 mirMAP -0.337423493141818 0.000268814744143244 NA NA NA hsa-miR-335-3p ABCA10 2.29463721765513 4.1956113745077e-18 -0.571454955019528 0.0367378237971729 mirMAP -0.299806674384373 2.58691664942465e-07 NA NA NA hsa-miR-335-3p ABCA6 2.29463721765513 4.1956113745077e-18 -1.08659820199063 0.000299802339283293 mirMAP -0.478784842886666 2.00686036268518e-14 NA NA NA hsa-miR-183-5p ABCA8 2.08412478942637 1.08931431254487e-10 -2.99190082801217 2.10585396600667e-10 MirTarget -0.867546774273738 4.73486001748913e-27 NA NA NA hsa-miR-192-5p ABCA8 2.0867723747501 3.57854249239079e-08 -2.99190082801217 2.10585396600667e-10 miRNAWalker2_validate -0.488500191150211 4.11167345797026e-11 NA NA NA hsa-miR-335-3p ABCA9 2.29463721765513 4.1956113745077e-18 -1.38320907832174 0.000165057716214178 mirMAP -0.531099946766841 6.66248885572808e-12 NA NA NA hsa-miR-935 ABCB1 2.321600496365 1.00042201726114e-07 -0.702125248027799 0.00396957271447112 MirTarget -0.188643828380427 5.02168782898237e-08 NA NA NA hsa-miR-146b-5p ABCB5 2.23105707690238 3.83997814011313e-23 -0.955542170385081 0.040765415736202 miRanda -0.602568344014611 1.43411713314698e-07 NA NA NA hsa-miR-146b-5p ABCC5 2.23105707690238 3.83997814011313e-23 -0.697746521385907 1.14243038167192e-06 PITA;miRanda;mirMAP -0.117161893275541 0.00124622642849227 NA NA NA hsa-miR-335-3p ABCD2 2.29463721765513 4.1956113745077e-18 -1.03833894941196 0.000499122644631738 MirTarget -0.37754030950117 2.58981381540523e-09 NA NA NA hsa-miR-146b-5p ABCG2 2.23105707690238 3.83997814011313e-23 -1.54628208869744 1.27179461943384e-06 miRanda -0.289057441248354 0.00034719955050132 NA NA NA hsa-miR-183-5p ABI2 2.08412478942637 1.08931431254487e-10 0.175334214271024 0.14786862779391 MirTarget -0.128330860490824 2.03192775958332e-09 NA NA NA hsa-miR-200b-3p ABI2 2.06025765178663 3.07718049337497e-10 0.175334214271024 0.14786862779391 TargetScan -0.168666434337723 2.27882307029266e-16 NA NA NA hsa-miR-146b-5p ABI3BP 2.23105707690238 3.83997814011313e-23 -2.06229963068915 1.30113975859438e-07 miRanda -0.572443762106354 4.04143269432698e-09 NA NA NA hsa-miR-200a-3p ABL1 2.02394729844446 2.21240501925011e-08 -0.214581652674921 0.0780394697492818 MirTarget -0.203458594312446 2.97713654349307e-30 NA NA NA hsa-miR-146b-5p ABLIM1 2.23105707690238 3.83997814011313e-23 -0.623904332213304 0.000192795317442126 mirMAP -0.114007805436353 0.00680233946182759 NA NA NA hsa-miR-146b-5p ACADM 2.23105707690238 3.83997814011313e-23 -1.0546038719736 3.74095803245068e-15 miRanda -0.196706607187436 1.09755115445584e-08 NA NA NA hsa-miR-146b-5p ACAT1 2.23105707690238 3.83997814011313e-23 -0.962552552536598 5.9887145919487e-14 miRanda -0.157477161898909 1.86492582843966e-06 NA NA NA hsa-miR-21-5p ACAT1 2.21515015440792 6.0468197386674e-49 -0.962552552536598 5.9887145919487e-14 miRNAWalker2_validate -0.323427434087958 1.30635045869468e-13 NA NA NA hsa-miR-146b-5p ACO1 2.23105707690238 3.83997814011313e-23 -0.752510924269316 3.97228193161905e-10 miRanda -0.148589989716049 1.07025970241849e-06 NA NA NA hsa-miR-335-3p ACSBG1 2.29463721765513 4.1956113745077e-18 -0.888245169055709 4.20985642335772e-05 mirMAP -0.292394782103288 2.16940442715357e-10 NA NA NA hsa-miR-146b-3p ACSL1 2.08650140817622 5.3293570720033e-22 -0.584863548769266 4.27832126568988e-05 PITA -0.117331260012318 0.00181380366973201 NA NA NA hsa-miR-192-5p ACSL1 2.0867723747501 3.57854249239079e-08 -0.584863548769266 4.27832126568988e-05 miRNAWalker2_validate -0.112204276874451 4.77898049716326e-07 NA NA NA hsa-miR-196a-5p ACSL6 5.05945965885472 4.48343841468539e-25 -1.59304412727914 8.277221937334e-07 miRNATAP -0.124506947084826 0.00101499159360962 NA NA NA hsa-miR-196b-5p ACSL6 4.51951031652328 7.04026169031626e-18 -1.59304412727914 8.277221937334e-07 miRNATAP -0.145502341362313 4.24190381315003e-05 NA NA NA hsa-miR-335-3p ACSL6 2.29463721765513 4.1956113745077e-18 -1.59304412727914 8.277221937334e-07 MirTarget -0.283442502161086 6.19150114782128e-05 NA NA NA hsa-miR-935 ACSL6 2.321600496365 1.00042201726114e-07 -1.59304412727914 8.277221937334e-07 PITA -0.260414768572726 2.20183355078912e-08 NA NA NA hsa-miR-335-3p ACSS3 2.29463721765513 4.1956113745077e-18 -0.400092431101115 0.155019644639014 MirTarget;mirMAP -0.181243405805862 0.00283709119092688 NA NA NA hsa-miR-146b-5p ACTC1 2.23105707690238 3.83997814011313e-23 -1.57313298964273 0.000506045776405804 miRanda -0.818196039870264 5.50802898444553e-14 NA NA NA hsa-miR-200b-3p ACTC1 2.06025765178663 3.07718049337497e-10 -1.57313298964273 0.000506045776405804 MirTarget -0.660925928855682 1.38261114331389e-17 NA NA NA hsa-miR-200b-3p ACTR1A 2.06025765178663 3.07718049337497e-10 -0.397609071151318 1.89148917623928e-07 TargetScan -0.108111914069706 2.12268301213487e-16 NA NA NA hsa-miR-146b-5p ADAL 2.23105707690238 3.83997814011313e-23 -0.342215214909785 0.0189321124543581 miRanda -0.120507539594028 0.00088919421940133 NA NA NA hsa-miR-200a-3p ADAM22 2.02394729844446 2.21240501925011e-08 0.642014834182602 0.00696242860211024 MirTarget -0.176435670014468 5.1701910538536e-06 NA NA NA hsa-miR-146b-5p ADAM23 2.23105707690238 3.83997814011313e-23 -0.70993590260262 0.00862612057079089 miRanda -0.300842999901529 6.84897683206893e-06 NA NA NA hsa-miR-335-3p ADAMTS17 2.29463721765513 4.1956113745077e-18 -0.450656972744946 0.113847018517461 MirTarget;mirMAP -0.127314017909085 0.0394356191770889 NA NA NA hsa-miR-200b-3p ADAMTS3 2.06025765178663 3.07718049337497e-10 0.381745529837852 0.0472261904397674 TargetScan -0.180784168617438 1.04752758962753e-07 NA NA NA hsa-miR-194-5p ADAMTS5 2.24386881692218 9.35116329002209e-11 0.188190214805037 0.2771550462378 mirMAP -0.104880246584617 0.000322779973144761 NA NA NA hsa-miR-200b-3p ADAMTS5 2.06025765178663 3.07718049337497e-10 0.188190214805037 0.2771550462378 mirMAP -0.164672128232313 6.55592559312006e-08 NA NA NA hsa-miR-335-3p ADAMTS8 2.29463721765513 4.1956113745077e-18 -1.47622920406741 0.00068832490768177 MirTarget -0.712953625406853 2.58771240948568e-15 NA NA NA hsa-miR-146b-5p ADAMTSL1 2.23105707690238 3.83997814011313e-23 -1.97710324648354 5.64877640106091e-16 miRanda -0.420931228395969 1.39199327380082e-11 NA NA NA hsa-miR-335-3p ADAMTSL1 2.29463721765513 4.1956113745077e-18 -1.97710324648354 5.64877640106091e-16 mirMAP -0.454669037561667 5.17892584786007e-18 NA NA NA hsa-miR-146b-5p ADARB1 2.23105707690238 3.83997814011313e-23 -0.335118787387249 0.0663097698612465 miRanda;mirMAP;miRNATAP -0.236437424891277 1.1670137808019e-07 NA NA NA hsa-miR-18a-5p ADARB1 2.04701000113742 1.30593450319289e-12 -0.335118787387249 0.0663097698612465 mirMAP -0.301859946810099 3.20235476538032e-18 NA NA NA hsa-miR-192-5p ADARB1 2.0867723747501 3.57854249239079e-08 -0.335118787387249 0.0663097698612465 mirMAP -0.265525045719081 4.1438440306653e-24 NA NA NA hsa-miR-200a-3p ADARB1 2.02394729844446 2.21240501925011e-08 -0.335118787387249 0.0663097698612465 MirTarget -0.315152195345093 1.3503423530429e-32 NA NA NA hsa-miR-146b-5p ADCY2 2.23105707690238 3.83997814011313e-23 -1.52957881268437 3.68996645479601e-05 miRanda -0.624939980693272 4.45283230485337e-12 NA NA NA hsa-miR-192-5p ADCY2 2.0867723747501 3.57854249239079e-08 -1.52957881268437 3.68996645479601e-05 mirMAP -0.489726269647626 7.20025525009783e-19 NA NA NA hsa-miR-200b-3p ADCY2 2.06025765178663 3.07718049337497e-10 -1.52957881268437 3.68996645479601e-05 MirTarget;TargetScan -0.621291864739548 1.72587422423198e-23 NA NA NA hsa-miR-21-5p ADCY2 2.21515015440792 6.0468197386674e-49 -1.52957881268437 3.68996645479601e-05 MirTarget -0.782174731097104 2.7468875524673e-10 NA NA NA hsa-miR-200b-3p ADCY9 2.06025765178663 3.07718049337497e-10 -0.36257850343414 0.0191055880639231 TargetScan -0.214341971832769 4.89518535816012e-16 NA NA NA hsa-miR-135b-5p ADCYAP1 2.80066701698235 2.12546333413447e-11 -1.70381479114522 0.000381054052101149 MirTarget -0.521709535413327 1.42439386666339e-14 NA NA NA hsa-miR-335-3p ADCYAP1 2.29463721765513 4.1956113745077e-18 -1.70381479114522 0.000381054052101149 mirMAP -0.591566094169295 7.12576310935833e-09 NA NA NA hsa-miR-146b-5p ADD1 2.23105707690238 3.83997814011313e-23 -0.508261413899399 1.04960157658648e-08 miRanda -0.166010422965514 1.30187505946207e-14 NA NA NA hsa-miR-200a-5p ADD2 2.19152245759943 3.17968183522514e-11 -0.328962361072831 0.345138350210874 mirMAP -0.455752841249479 1.06284481780027e-14 NA NA NA hsa-miR-146b-5p ADH5 2.23105707690238 3.83997814011313e-23 -0.368960300330071 0.000134691028852477 miRanda -0.109611536943422 4.55858690414158e-06 NA NA NA hsa-miR-1-3p ADPGK -2.73171785118192 3.4424534921136e-12 0.631221390147201 3.93450589261846e-12 MirTarget -0.115111643400518 2.08077834405686e-18 NA NA NA hsa-miR-146b-5p ADRB2 2.23105707690238 3.83997814011313e-23 -2.77607289745493 7.42075616046658e-20 miRanda -0.489860690279711 7.06202226263046e-10 NA NA NA hsa-miR-146b-5p ADRB3 2.23105707690238 3.83997814011313e-23 -2.9039295141568 4.50387557579472e-09 miRanda -0.889517390996528 3.06325429411054e-13 NA NA NA hsa-miR-18a-5p AFAP1 2.04701000113742 1.30593450319289e-12 0.338310095115414 0.0122170069994409 mirMAP -0.166701916927869 3.42863099929015e-10 NA NA NA hsa-miR-192-5p AFAP1 2.0867723747501 3.57854249239079e-08 0.338310095115414 0.0122170069994409 mirMAP -0.141415672044648 4.12979377983602e-12 NA NA NA hsa-miR-200a-3p AFAP1 2.02394729844446 2.21240501925011e-08 0.338310095115414 0.0122170069994409 mirMAP -0.179457448179425 7.12216408995512e-18 NA NA NA hsa-miR-146b-5p AFAP1L2 2.23105707690238 3.83997814011313e-23 -0.283613312664616 0.154340021206349 miRanda;miRNATAP -0.198862251305203 5.26491147013215e-05 NA NA NA hsa-miR-200b-3p AFF1 2.06025765178663 3.07718049337497e-10 -0.38392701055879 0.000534832405102977 TargetScan -0.135739567609764 1.9152841266992e-12 NA NA NA hsa-miR-141-5p AFF3 2.13747696823946 1.73124674554872e-11 -2.37331346400795 1.1482078568002e-10 mirMAP -0.656885716459181 2.61092934701361e-24 NA NA NA hsa-miR-200a-5p AFF3 2.19152245759943 3.17968183522514e-11 -2.37331346400795 1.1482078568002e-10 MirTarget -0.562308589630398 9.77153010782168e-19 NA NA NA hsa-miR-200b-3p AFF3 2.06025765178663 3.07718049337497e-10 -2.37331346400795 1.1482078568002e-10 MirTarget;TargetScan -0.563896340686397 2.42200688738896e-18 NA NA NA hsa-miR-335-3p AFF3 2.29463721765513 4.1956113745077e-18 -2.37331346400795 1.1482078568002e-10 mirMAP -0.696546737429298 1.66933867565395e-19 NA NA NA hsa-miR-18a-5p AFF4 2.04701000113742 1.30593450319289e-12 -0.266238435778205 0.0156473179650327 miRNAWalker2_validate -0.148452075199908 4.41395051368717e-12 NA NA NA hsa-miR-146b-3p AGPAT4 2.08650140817622 5.3293570720033e-22 0.0930866987009771 0.613205838182191 mirMAP -0.126050480560423 0.00850994296164677 NA NA NA hsa-miR-18a-5p AGPAT4 2.04701000113742 1.30593450319289e-12 0.0930866987009771 0.613205838182191 mirMAP -0.206814857042633 1.2291691784234e-08 NA NA NA hsa-miR-200a-3p AGPAT4 2.02394729844446 2.21240501925011e-08 0.0930866987009771 0.613205838182191 mirMAP -0.211574202283831 2.19928243128267e-13 NA NA NA hsa-miR-335-3p AGPAT4 2.29463721765513 4.1956113745077e-18 0.0930866987009771 0.613205838182191 mirMAP -0.180501935757313 4.06100766830225e-06 NA NA NA hsa-miR-146b-5p AHNAK 2.23105707690238 3.83997814011313e-23 -1.2069240076455 1.34650096153062e-09 miRanda -0.367203352595483 6.3028377851069e-14 NA NA NA hsa-miR-200b-3p AHNAK 2.06025765178663 3.07718049337497e-10 -1.2069240076455 1.34650096153062e-09 TargetScan -0.315757295187101 5.23497379185866e-20 NA NA NA hsa-miR-335-3p AICDA 2.29463721765513 4.1956113745077e-18 0.178758527833101 0.699181327625347 mirMAP -0.205671147922765 0.0400324267073385 NA NA NA hsa-miR-141-5p AIF1L 2.13747696823946 1.73124674554872e-11 -1.33049412501995 2.34016175868789e-05 MirTarget -0.236076693992915 5.36203086523236e-05 NA NA NA hsa-miR-146b-3p AJAP1 2.08650140817622 5.3293570720033e-22 -0.561336464748573 0.0483193224393427 miRNATAP -0.20431066506869 0.00593604255920994 NA NA NA hsa-miR-183-5p AJAP1 2.08412478942637 1.08931431254487e-10 -0.561336464748573 0.0483193224393427 MirTarget -0.176445888739413 0.000638952473202848 NA NA NA hsa-miR-200a-3p AK4 2.02394729844446 2.21240501925011e-08 -1.11655840159903 0.00017402069474046 miRNATAP -0.203884566538681 3.03661990485175e-05 NA NA NA hsa-miR-200b-3p AK4 2.06025765178663 3.07718049337497e-10 -1.11655840159903 0.00017402069474046 mirMAP -0.240874077126371 6.77159497292565e-06 NA NA NA hsa-miR-335-3p AK4 2.29463721765513 4.1956113745077e-18 -1.11655840159903 0.00017402069474046 mirMAP -0.233425104834894 0.00030732690168859 NA NA NA hsa-miR-935 AK4 2.321600496365 1.00042201726114e-07 -1.11655840159903 0.00017402069474046 MirTarget;mirMAP -0.125759848280843 0.0037112416973232 NA NA NA hsa-miR-135b-5p AKAP12 2.80066701698235 2.12546333413447e-11 -0.931840498501576 0.00280002417909614 mirMAP -0.344981871751495 3.3555332529212e-15 NA NA NA hsa-miR-183-5p AKAP12 2.08412478942637 1.08931431254487e-10 -0.931840498501576 0.00280002417909614 miRNAWalker2_validate;miRTarBase -0.573047168308188 7.07407121257084e-29 NA NA NA hsa-miR-335-3p AKAP13 2.29463721765513 4.1956113745077e-18 0.0284238659194367 0.772901440209078 mirMAP -0.107226816417792 2.3048973394245e-07 NA NA NA hsa-miR-21-5p AKAP6 2.21515015440792 6.0468197386674e-49 -1.5859382164449 2.59229251555629e-05 MirTarget -0.921248765784477 1.2819949214479e-13 NA NA NA hsa-miR-335-3p AKAP6 2.29463721765513 4.1956113745077e-18 -1.5859382164449 2.59229251555629e-05 mirMAP -0.609870486820004 9.74684628062071e-15 NA NA NA hsa-miR-92a-1-5p AKAP6 2.04820501765632 9.32117486799495e-13 -1.5859382164449 2.59229251555629e-05 MirTarget -0.653281191116295 1.75910146376339e-18 NA NA NA hsa-miR-21-5p AKIRIN1 2.21515015440792 6.0468197386674e-49 -0.250208137464423 0.00143547856469275 miRNATAP -0.109040830797926 3.47253940370792e-05 NA NA NA hsa-miR-141-5p AKNAD1 2.13747696823946 1.73124674554872e-11 -0.462380232954642 0.000163576266875212 MirTarget -0.108080919043357 1.52350417463152e-06 NA NA NA hsa-miR-21-5p AKT2 2.21515015440792 6.0468197386674e-49 -0.163157777800721 0.0933816097673111 miRNAWalker2_validate -0.125319232582453 0.000121164702766457 NA NA NA hsa-miR-146b-5p AKT3 2.23105707690238 3.83997814011313e-23 -0.273001052722672 0.188651193580836 miRNAWalker2_validate -0.255166569260379 5.2556904982786e-07 NA NA NA hsa-miR-335-3p AKT3 2.29463721765513 4.1956113745077e-18 -0.273001052722672 0.188651193580836 mirMAP -0.30313372364369 2.03502007738655e-12 NA NA NA hsa-miR-335-3p ALAD 2.29463721765513 4.1956113745077e-18 -0.720655379378628 9.04676723293442e-15 mirMAP -0.150833687047513 6.66568791837008e-14 NA NA NA hsa-miR-194-5p ALDH1L2 2.24386881692218 9.35116329002209e-11 0.227342618523468 0.320964073992958 mirMAP -0.14459697803527 0.000177436955597621 NA NA NA hsa-miR-335-3p ALDH1L2 2.29463721765513 4.1956113745077e-18 0.227342618523468 0.320964073992958 MirTarget -0.146595964872285 0.00298404140592969 NA NA NA hsa-miR-183-5p AMIGO2 2.08412478942637 1.08931431254487e-10 0.610030607253541 0.0190294565433556 MirTarget -0.158421648821418 0.000825180690068149 NA NA NA hsa-miR-192-5p AMOTL1 2.0867723747501 3.57854249239079e-08 -0.486379931315175 0.054603870149297 mirMAP -0.436941859511699 1.8587501351158e-36 NA NA NA hsa-miR-335-3p AMOTL1 2.29463721765513 4.1956113745077e-18 -0.486379931315175 0.054603870149297 mirMAP -0.312556932040887 4.82910708391079e-09 NA NA NA hsa-miR-200b-3p AMOTL2 2.06025765178663 3.07718049337497e-10 0.146193942930294 0.30776365924427 MirTarget;TargetScan -0.110709235845408 1.3504727226348e-05 NA NA NA hsa-miR-146b-5p AMPH 2.23105707690238 3.83997814011313e-23 -0.916118138195441 5.14935774459211e-05 PITA;miRanda -0.351086663273956 2.38282988450335e-10 NA NA NA hsa-miR-146b-5p ANGPT1 2.23105707690238 3.83997814011313e-23 -1.11728763573643 2.03295126213193e-06 miRanda -0.355487898065865 9.44163829721527e-10 NA NA NA hsa-miR-335-3p ANGPT1 2.29463721765513 4.1956113745077e-18 -1.11728763573643 2.03295126213193e-06 mirMAP -0.349314779228241 2.36033064642181e-12 NA NA NA hsa-miR-146b-5p ANGPTL1 2.23105707690238 3.83997814011313e-23 -2.70918991718092 4.5661188728075e-09 miRanda -0.904473862023952 9.98256257963015e-16 NA NA NA hsa-miR-194-5p ANGPTL1 2.24386881692218 9.35116329002209e-11 -2.70918991718092 4.5661188728075e-09 MirTarget -0.77138977686372 1.08840245690299e-25 NA NA NA hsa-miR-200a-3p ANGPTL1 2.02394729844446 2.21240501925011e-08 -2.70918991718092 4.5661188728075e-09 MirTarget -0.905826379777955 5.69700281090288e-42 NA NA NA hsa-miR-135b-5p ANGPTL2 2.80066701698235 2.12546333413447e-11 -0.0237379541408558 0.917481753435316 MirTarget -0.191866896765731 4.52707178407974e-09 NA NA NA hsa-miR-146b-5p ANGPTL2 2.23105707690238 3.83997814011313e-23 -0.0237379541408558 0.917481753435316 miRanda -0.177455499142076 0.00180330455069431 NA NA NA hsa-miR-335-3p ANGPTL3 2.29463721765513 4.1956113745077e-18 -1.67727191705753 2.52393178920104e-05 mirMAP -0.292895476889036 0.000766022021998783 NA NA NA hsa-miR-146b-5p ANK2 2.23105707690238 3.83997814011313e-23 -1.60257109400243 5.33587507985444e-06 PITA;miRanda -0.598354638909948 3.48122506831567e-12 NA NA NA hsa-miR-200a-3p ANK2 2.02394729844446 2.21240501925011e-08 -1.60257109400243 5.33587507985444e-06 miRNATAP -0.628085829649956 8.16782385243089e-34 NA NA NA hsa-miR-335-3p ANK2 2.29463721765513 4.1956113745077e-18 -1.60257109400243 5.33587507985444e-06 mirMAP -0.574544788213085 6.50394098038723e-15 NA NA NA hsa-miR-146b-5p ANKDD1A 2.23105707690238 3.83997814011313e-23 -0.337237844486373 0.0367978971869057 miRanda -0.146082836979651 0.000265590361662217 NA NA NA hsa-miR-335-3p ANKRD12 2.29463721765513 4.1956113745077e-18 -0.232235450390739 0.0452061761249606 MirTarget -0.119343175932974 1.25310588594761e-06 NA NA NA hsa-miR-335-3p ANKRD29 2.29463721765513 4.1956113745077e-18 -1.34789320693404 8.2268003911958e-06 MirTarget;mirMAP -0.434072952624523 1.26393337548313e-11 NA NA NA hsa-miR-135b-5p ANKRD33B 2.80066701698235 2.12546333413447e-11 -1.0286652041065 0.000112617270925594 MirTarget -0.26806440758731 1.86069314197745e-12 NA NA NA hsa-miR-146b-5p ANKRD35 2.23105707690238 3.83997814011313e-23 -1.96404696484974 4.46085236801958e-13 miRanda -0.573313634514113 7.55493177381981e-18 NA NA NA hsa-miR-183-5p ANKRD50 2.08412478942637 1.08931431254487e-10 0.273676885535242 0.0403389629416704 MirTarget -0.110829373242903 3.78614034822249e-06 NA NA NA hsa-miR-18a-5p ANKRD50 2.04701000113742 1.30593450319289e-12 0.273676885535242 0.0403389629416704 MirTarget;miRNATAP -0.151913143225935 8.15599316111448e-09 NA NA NA hsa-miR-192-5p ANKRD6 2.0867723747501 3.57854249239079e-08 -0.362693205944883 0.0394241452373118 miRNAWalker2_validate -0.21297280927049 3.86019911992963e-16 NA NA NA hsa-miR-335-3p ANKRD6 2.29463721765513 4.1956113745077e-18 -0.362693205944883 0.0394241452373118 mirMAP -0.195485377737317 1.69073395048237e-07 NA NA NA hsa-miR-146b-5p ANKS1A 2.23105707690238 3.83997814011313e-23 -0.13350994800444 0.229491244188813 mirMAP -0.176157203188192 3.69010045502025e-11 NA NA NA hsa-miR-21-5p ANKS1B 2.21515015440792 6.0468197386674e-49 -0.221125933204358 0.128367458944912 MirTarget -0.16944033888376 0.000554400494054826 NA NA NA hsa-miR-335-3p ANKS1B 2.29463721765513 4.1956113745077e-18 -0.221125933204358 0.128367458944912 mirMAP -0.106159712408716 0.00067761993410723 NA NA NA hsa-miR-146b-5p ANO5 2.23105707690238 3.83997814011313e-23 -2.17078328848367 8.0164866381684e-07 miRanda -0.738232291030088 8.16524449871847e-12 NA NA NA hsa-miR-200a-3p ANO5 2.02394729844446 2.21240501925011e-08 -2.17078328848367 8.0164866381684e-07 mirMAP -0.424110109602328 3.55847778334293e-09 NA NA NA hsa-miR-200b-3p ANO5 2.06025765178663 3.07718049337497e-10 -2.17078328848367 8.0164866381684e-07 TargetScan -0.490376267388203 4.32101550307116e-10 NA NA NA hsa-miR-192-5p ANO6 2.0867723747501 3.57854249239079e-08 -0.0852083698444357 0.502269433202532 miRNAWalker2_validate -0.10991132446706 1.35656993437427e-08 NA NA NA hsa-miR-200a-3p ANO6 2.02394729844446 2.21240501925011e-08 -0.0852083698444357 0.502269433202532 MirTarget -0.161774709038674 1.46926544764385e-16 NA NA NA hsa-miR-200b-3p ANO6 2.06025765178663 3.07718049337497e-10 -0.0852083698444357 0.502269433202532 TargetScan -0.163682649982031 4.96272712542492e-14 NA NA NA hsa-miR-335-3p ANTXR1 2.29463721765513 4.1956113745077e-18 0.824541697719349 0.00013866646046424 mirMAP -0.10225759278657 0.0310314653052958 NA NA NA hsa-miR-335-3p ANTXR2 2.29463721765513 4.1956113745077e-18 -0.725355669636325 0.00186407729445627 MirTarget -0.323143035977995 4.46286098688478e-11 NA NA NA hsa-miR-146b-5p ANXA3 2.23105707690238 3.83997814011313e-23 -0.501756779836798 0.0289015205519311 miRanda -0.13325739209587 0.0204538567021495 NA NA NA hsa-miR-1-3p ANXA4 -2.73171785118192 3.4424534921136e-12 0.620963461284372 0.000579762639118652 MirTarget -0.139547948930316 1.46645836789073e-07 NA NA NA hsa-miR-146b-5p AOC3 2.23105707690238 3.83997814011313e-23 -1.4157913896426 1.12729557434032e-05 miRanda -0.569278245999187 3.62818316141934e-13 NA NA NA hsa-miR-335-3p AOX1 2.29463721765513 4.1956113745077e-18 -1.36733513877406 0.000359632233931027 mirMAP -0.407542197513332 7.48323215002606e-07 NA NA NA hsa-miR-1-3p AP1S1 -2.73171785118192 3.4424534921136e-12 0.363896224944477 0.0236103871977666 MirTarget -0.124519429705054 1.13238451729018e-07 NA NA NA hsa-miR-141-5p AP1S2 2.13747696823946 1.73124674554872e-11 -0.606780926693101 0.00205224777129082 MirTarget -0.433680756127644 7.28503896136305e-45 NA NA NA hsa-miR-192-5p AP1S2 2.0867723747501 3.57854249239079e-08 -0.606780926693101 0.00205224777129082 miRNAWalker2_validate -0.339299903270277 7.57738254499468e-36 NA NA NA hsa-miR-200b-3p AP1S2 2.06025765178663 3.07718049337497e-10 -0.606780926693101 0.00205224777129082 MirTarget;TargetScan -0.409677325624998 5.51773958449442e-41 NA NA NA hsa-miR-335-3p AP1S2 2.29463721765513 4.1956113745077e-18 -0.606780926693101 0.00205224777129082 mirMAP -0.290626594985348 1.60481645463934e-12 NA NA NA hsa-miR-146b-5p AP3B2 2.23105707690238 3.83997814011313e-23 -1.54528039109004 0.000670600286743025 miRanda -0.671851278339501 1.56288770218178e-09 NA NA NA hsa-miR-146b-3p APBA1 2.08650140817622 5.3293570720033e-22 -0.360211295752882 0.0544078405430636 MirTarget -0.242866039778666 4.26503902247605e-07 NA NA NA hsa-miR-200a-3p APBB2 2.02394729844446 2.21240501925011e-08 0.203347165018092 0.117144652504761 MirTarget;miRNATAP -0.127763033270903 5.74493527441552e-10 NA NA NA hsa-miR-21-5p APH1B 2.21515015440792 6.0468197386674e-49 -0.153227927107797 0.319933217906237 MirTarget -0.131367483895683 0.0118730324916462 NA NA NA hsa-miR-335-3p APH1B 2.29463721765513 4.1956113745077e-18 -0.153227927107797 0.319933217906237 mirMAP -0.121134983254862 0.000242201224308006 NA NA NA hsa-miR-146b-5p APLF 2.23105707690238 3.83997814011313e-23 -0.240259426206283 0.123057631883448 miRanda -0.144035340934715 0.000185850023313728 NA NA NA hsa-miR-335-3p APLF 2.29463721765513 4.1956113745077e-18 -0.240259426206283 0.123057631883448 mirMAP -0.116095583667721 0.000522818253872749 NA NA NA hsa-miR-18a-5p APOLD1 2.04701000113742 1.30593450319289e-12 -0.383751863841876 0.0485139708584483 mirMAP -0.213488424357576 3.08853816586552e-08 NA NA NA hsa-miR-192-5p APOLD1 2.0867723747501 3.57854249239079e-08 -0.383751863841876 0.0485139708584483 miRNAWalker2_validate -0.128346096274816 2.16150212923558e-05 NA NA NA hsa-miR-21-5p APOLD1 2.21515015440792 6.0468197386674e-49 -0.383751863841876 0.0485139708584483 miRNAWalker2_validate -0.279710503336859 1.91741828890753e-05 NA NA NA hsa-miR-146b-5p AQP10 2.23105707690238 3.83997814011313e-23 -4.25937055248363 7.64804818692609e-14 miRanda -0.60079617228371 5.00697768827942e-05 NA NA NA hsa-miR-200a-3p AQP4 2.02394729844446 2.21240501925011e-08 -6.0976799210241 2.93828507115081e-24 mirMAP -0.44628998139312 3.0482260037586e-05 NA NA NA hsa-miR-200b-3p AQP4 2.06025765178663 3.07718049337497e-10 -6.0976799210241 2.93828507115081e-24 mirMAP -0.552832679265062 2.27426406799079e-06 NA NA NA hsa-miR-146b-5p AR 2.23105707690238 3.83997814011313e-23 -1.55428586679464 3.79681953414866e-06 mirMAP -0.619094133474725 3.00106486408542e-14 NA NA NA hsa-miR-200a-3p AR 2.02394729844446 2.21240501925011e-08 -1.55428586679464 3.79681953414866e-06 mirMAP -0.614503691518376 6.11584695391378e-36 24391862 We identified miR-200 b as a downstream target of androgen receptor and linked its expression to decreased tumorigenicity and metastatic capacity of the prostate cancer cells prostate cancer hsa-miR-200a-5p AR 2.19152245759943 3.17968183522514e-11 -1.55428586679464 3.79681953414866e-06 miRNATAP -0.655097424684105 1.92783771963403e-34 24391862 We identified miR-200 b as a downstream target of androgen receptor and linked its expression to decreased tumorigenicity and metastatic capacity of the prostate cancer cells prostate cancer hsa-miR-335-3p AR 2.29463721765513 4.1956113745077e-18 -1.55428586679464 3.79681953414866e-06 mirMAP -0.5744710704242 2.30589448788097e-16 NA NA NA hsa-miR-335-3p ARHGAP15 2.29463721765513 4.1956113745077e-18 -0.42376386276765 0.0522112330368926 mirMAP -0.271478716968493 3.66833907075224e-09 NA NA NA hsa-miR-200b-3p ARHGAP20 2.06025765178663 3.07718049337497e-10 -1.37521379031409 6.54964322003788e-07 MirTarget;TargetScan -0.525093352316807 4.62765133109738e-31 NA NA NA hsa-miR-194-5p ARHGAP24 2.24386881692218 9.35116329002209e-11 -0.927541628859573 3.46810617901546e-06 miRNATAP -0.162824470807963 1.68639464346024e-06 NA NA NA hsa-miR-200a-3p ARHGAP24 2.02394729844446 2.21240501925011e-08 -0.927541628859573 3.46810617901546e-06 miRNATAP -0.205503601520138 2.10373275424976e-10 NA NA NA hsa-miR-21-5p ARHGAP24 2.21515015440792 6.0468197386674e-49 -0.927541628859573 3.46810617901546e-06 MirTarget;miRNATAP -0.365985728070621 6.35569493102462e-08 NA NA NA hsa-miR-196b-5p ARHGAP28 4.51951031652328 7.04026169031626e-18 -0.91108155777335 0.000128114021946718 MirTarget;miRNATAP -0.107000061520367 3.6099232728843e-05 NA NA NA hsa-miR-200b-3p ARHGAP28 2.06025765178663 3.07718049337497e-10 -0.91108155777335 0.000128114021946718 MirTarget -0.210891521475018 7.57287049033546e-07 NA NA NA hsa-miR-335-3p ARHGAP28 2.29463721765513 4.1956113745077e-18 -0.91108155777335 0.000128114021946718 MirTarget -0.203604116145475 7.97523332212529e-05 NA NA NA hsa-miR-192-5p ARHGAP29 2.0867723747501 3.57854249239079e-08 0.131379720033421 0.429533510526147 miRNAWalker2_validate -0.133997834211656 1.49251889090626e-07 NA NA NA hsa-miR-135b-5p ARHGAP6 2.80066701698235 2.12546333413447e-11 -0.528937130002503 0.0400586038016635 MirTarget -0.201972434869045 5.27118558706116e-08 NA NA NA hsa-miR-146b-5p ARHGAP6 2.23105707690238 3.83997814011313e-23 -0.528937130002503 0.0400586038016635 PITA;miRanda -0.31343761586599 7.42483996808166e-07 NA NA NA hsa-miR-183-5p ARHGAP6 2.08412478942637 1.08931431254487e-10 -0.528937130002503 0.0400586038016635 MirTarget;miRNATAP -0.411223286439663 4.14684014784138e-21 NA NA NA hsa-miR-200b-3p ARHGAP6 2.06025765178663 3.07718049337497e-10 -0.528937130002503 0.0400586038016635 MirTarget;TargetScan -0.294522253525362 5.68779920266667e-11 NA NA NA hsa-miR-192-5p ARHGEF10 2.0867723747501 3.57854249239079e-08 -0.0978946958084785 0.610003579994436 miRNAWalker2_validate -0.174267226405221 2.48276070321823e-09 NA NA NA hsa-miR-200b-3p ARHGEF17 2.06025765178663 3.07718049337497e-10 0.034326144778178 0.858945227172506 TargetScan -0.337457388320201 6.42116541129292e-27 NA NA NA hsa-miR-192-5p ARHGEF26 2.0867723747501 3.57854249239079e-08 -1.95662528882127 5.95096344991847e-08 miRNAWalker2_validate -0.50938422082555 3.08532273084327e-21 NA NA NA hsa-miR-335-3p ARHGEF33 2.29463721765513 4.1956113745077e-18 -0.332646269001273 0.129590275197022 mirMAP -0.205567439170157 1.16509134170364e-05 NA NA NA hsa-miR-192-5p ARHGEF37 2.0867723747501 3.57854249239079e-08 -1.65698157114246 2.20895565711032e-14 mirMAP -0.15805688069343 8.00487244876738e-06 NA NA NA hsa-miR-935 ARHGEF37 2.321600496365 1.00042201726114e-07 -1.65698157114246 2.20895565711032e-14 MirTarget -0.219995111109993 3.98859460061741e-12 NA NA NA hsa-miR-135b-5p ARHGEF4 2.80066701698235 2.12546333413447e-11 -1.41023783025306 0.000300648255322125 miRNATAP -0.311540649108948 3.86755583480273e-08 NA NA NA hsa-miR-146b-5p ARHGEF4 2.23105707690238 3.83997814011313e-23 -1.41023783025306 0.000300648255322125 miRanda -0.73042302428872 5.76452014507197e-15 NA NA NA hsa-miR-135b-5p ARHGEF6 2.80066701698235 2.12546333413447e-11 -0.62108968409016 0.00125220337523234 MirTarget -0.228951926737978 1.21594785659422e-17 NA NA NA hsa-miR-200b-3p ARHGEF6 2.06025765178663 3.07718049337497e-10 -0.62108968409016 0.00125220337523234 mirMAP -0.267660929440587 5.67279351998819e-16 NA NA NA hsa-miR-135b-5p ARL10 2.80066701698235 2.12546333413447e-11 -0.28129009619869 0.198316212901093 mirMAP -0.192842351449268 6.06340653466775e-10 NA NA NA hsa-miR-146b-5p ARL10 2.23105707690238 3.83997814011313e-23 -0.28129009619869 0.198316212901093 MirTarget;miRanda -0.241898081510758 6.94899366142087e-06 NA NA NA hsa-miR-200a-3p ARL10 2.02394729844446 2.21240501925011e-08 -0.28129009619869 0.198316212901093 mirMAP -0.306826430162628 3.72450577851417e-20 NA NA NA hsa-miR-200b-3p ARL10 2.06025765178663 3.07718049337497e-10 -0.28129009619869 0.198316212901093 mirMAP -0.326846489836631 6.85280307532961e-19 NA NA NA hsa-miR-335-3p ARL10 2.29463721765513 4.1956113745077e-18 -0.28129009619869 0.198316212901093 mirMAP -0.222146830256476 1.80852286072911e-06 NA NA NA hsa-miR-935 ARL10 2.321600496365 1.00042201726114e-07 -0.28129009619869 0.198316212901093 mirMAP -0.139905656783756 6.94679794748601e-06 NA NA NA hsa-miR-192-5p ARL2BP 2.0867723747501 3.57854249239079e-08 -0.343286861480952 3.24929129460008e-05 miRNAWalker2_validate;MirTarget -0.105115494989654 8.87252420866826e-18 NA NA NA hsa-miR-200b-3p ARL2BP 2.06025765178663 3.07718049337497e-10 -0.343286861480952 3.24929129460008e-05 TargetScan -0.111898694101105 3.38650428950985e-15 NA NA NA hsa-miR-200b-3p ARL3 2.06025765178663 3.07718049337497e-10 -0.521628086406404 2.45297123307517e-07 TargetScan -0.1512050080486 3.28914199335082e-18 NA NA NA hsa-miR-133a-3p ARL6IP1 -2.63342156915404 5.72661351480585e-12 0.577537808488563 1.35778175758293e-05 miRNAWalker2_validate -0.144213438055402 2.66374212433194e-13 NA NA NA hsa-miR-21-5p ARMCX1 2.21515015440792 6.0468197386674e-49 -1.27825493561566 1.80518168021065e-08 MirTarget -0.613846269184315 2.67046618801879e-16 NA NA NA hsa-miR-21-5p ARMCX3 2.21515015440792 6.0468197386674e-49 -0.174723325566402 0.294467880066106 miRNAWalker2_validate -0.118942541202785 0.03566440612269 NA NA NA hsa-miR-200a-3p ARNT2 2.02394729844446 2.21240501925011e-08 -0.332178452162526 0.258506029820392 mirMAP -0.211722333063986 8.78888171968958e-06 NA NA NA hsa-miR-935 ARNT2 2.321600496365 1.00042201726114e-07 -0.332178452162526 0.258506029820392 PITA;miRNATAP -0.202594021665103 1.1989045819824e-06 NA NA NA hsa-miR-146b-5p ARRB1 2.23105707690238 3.83997814011313e-23 -0.800597632511845 3.73849503393459e-07 miRanda -0.260346835475454 1.71027820064312e-11 NA NA NA hsa-miR-200a-3p ARRB1 2.02394729844446 2.21240501925011e-08 -0.800597632511845 3.73849503393459e-07 MirTarget -0.117903464771123 6.01454984191194e-06 NA NA NA hsa-miR-200b-3p ARRDC3 2.06025765178663 3.07718049337497e-10 -0.146523158782965 0.287414873160273 TargetScan -0.121212288058031 6.12636605988112e-07 NA NA NA hsa-miR-335-3p ARRDC3 2.29463721765513 4.1956113745077e-18 -0.146523158782965 0.287414873160273 MirTarget;mirMAP -0.113922370933278 0.00010934448360885 NA NA NA hsa-miR-335-3p ARSG 2.29463721765513 4.1956113745077e-18 -0.908619814094625 1.40668388929276e-07 mirMAP -0.186368741745182 6.89792662221973e-07 NA NA NA hsa-miR-21-5p ART4 2.21515015440792 6.0468197386674e-49 -0.76696371479558 0.077202577833615 mirMAP -0.501754482429449 0.000644064352891211 NA NA NA hsa-miR-194-5p ASAP1 2.24386881692218 9.35116329002209e-11 0.655989763998995 2.1623533190386e-07 MirTarget;miRNATAP -0.101024675272178 2.91834423680092e-06 NA NA NA hsa-miR-141-5p ASB1 2.13747696823946 1.73124674554872e-11 -0.275456210497773 0.00868427409528013 mirMAP -0.163109098693499 1.78752653827943e-19 NA NA NA hsa-miR-146b-5p ASB1 2.23105707690238 3.83997814011313e-23 -0.275456210497773 0.00868427409528013 miRanda -0.178447309224634 1.1933442020421e-12 NA NA NA hsa-miR-183-5p ASB1 2.08412478942637 1.08931431254487e-10 -0.275456210497773 0.00868427409528013 mirMAP -0.122950410713118 2.68794001539303e-11 NA NA NA hsa-miR-18a-5p ASB1 2.04701000113742 1.30593450319289e-12 -0.275456210497773 0.00868427409528013 mirMAP -0.129749906203687 2.99448308985408e-10 NA NA NA hsa-miR-200a-3p ASB1 2.02394729844446 2.21240501925011e-08 -0.275456210497773 0.00868427409528013 mirMAP -0.132935967631233 3.16697170643501e-16 NA NA NA hsa-miR-335-3p ASB1 2.29463721765513 4.1956113745077e-18 -0.275456210497773 0.00868427409528013 mirMAP -0.10820991242605 1.2497083426651e-06 NA NA NA hsa-miR-135b-5p ASPA 2.80066701698235 2.12546333413447e-11 -2.91318120737698 1.41517316235254e-17 mirMAP -0.38381226816137 6.10824402762675e-14 NA NA NA hsa-miR-335-3p ASPN 2.29463721765513 4.1956113745077e-18 1.54956784701552 1.66789688217998e-06 mirMAP -0.153077614938489 0.0323028616379706 NA NA NA hsa-miR-18a-5p ASTN1 2.04701000113742 1.30593450319289e-12 -2.38850445662267 1.79346320545124e-05 MirTarget -0.802345749026485 2.65510539340638e-13 NA NA NA hsa-miR-200a-3p ASTN1 2.02394729844446 2.21240501925011e-08 -2.38850445662267 1.79346320545124e-05 MirTarget;miRNATAP -0.863009459331764 3.23121822239526e-24 NA NA NA hsa-miR-200b-3p ASXL3 2.06025765178663 3.07718049337497e-10 -1.87842198623791 7.63940713243169e-08 TargetScan -0.455451974562606 1.67265650550218e-13 NA NA NA hsa-miR-335-3p ASXL3 2.29463721765513 4.1956113745077e-18 -1.87842198623791 7.63940713243169e-08 mirMAP -0.471426492140127 3.61061493413464e-10 NA NA NA hsa-miR-935 ASXL3 2.321600496365 1.00042201726114e-07 -1.87842198623791 7.63940713243169e-08 mirMAP -0.334144788605402 2.15254718397085e-11 NA NA NA hsa-miR-92a-1-5p ATCAY 2.04820501765632 9.32117486799495e-13 -2.16626822179922 1.42047092033792e-06 mirMAP -0.691258290471451 2.63137260744276e-14 NA NA NA hsa-miR-135b-5p ATF3 2.80066701698235 2.12546333413447e-11 -1.16157999750188 2.04276049390805e-06 MirTarget -0.10661448379309 0.00354689618503821 NA NA NA hsa-miR-146b-5p ATF3 2.23105707690238 3.83997814011313e-23 -1.16157999750188 2.04276049390805e-06 miRanda -0.203875126427287 0.000997974970321433 NA NA NA hsa-miR-18a-5p ATF7 2.04701000113742 1.30593450319289e-12 0.0674049536109402 0.438061225007579 mirMAP -0.128936136859385 7.53877543470037e-15 NA NA NA hsa-miR-192-5p ATF7 2.0867723747501 3.57854249239079e-08 0.0674049536109402 0.438061225007579 miRNATAP -0.108879680051366 9.40088042920845e-18 NA NA NA hsa-miR-200b-3p ATF7 2.06025765178663 3.07718049337497e-10 0.0674049536109402 0.438061225007579 mirMAP -0.122016697667442 7.24594297196532e-17 NA NA NA hsa-miR-183-5p ATL2 2.08412478942637 1.08931431254487e-10 -0.383786242998031 0.000575339633888933 MirTarget;miRNATAP -0.127144858819215 1.23503444127145e-10 NA NA NA hsa-miR-18a-5p ATL2 2.04701000113742 1.30593450319289e-12 -0.383786242998031 0.000575339633888933 MirTarget -0.114433288726876 2.76314125604766e-07 NA NA NA hsa-miR-200b-3p ATL2 2.06025765178663 3.07718049337497e-10 -0.383786242998031 0.000575339633888933 MirTarget;TargetScan -0.144410609905955 6.55387849763679e-14 NA NA NA hsa-miR-18a-5p ATM 2.04701000113742 1.30593450319289e-12 0.177849811817311 0.2156767159682 miRNAWalker2_validate;miRTarBase;MirTarget -0.106088412949694 0.000233162954700209 23437304;25963391;23857602;23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression colorectal cancer;cervical and endocervical cancer;breast cancer;colon cancer hsa-miR-192-5p ATP10D 2.0867723747501 3.57854249239079e-08 -0.370662483390109 0.00764032733906965 miRNAWalker2_validate -0.118803952333699 2.63436462290521e-08 NA NA NA hsa-miR-335-3p ATP1A2 2.29463721765513 4.1956113745077e-18 -3.50104794842637 2.73038246823912e-10 MirTarget -1.09887474991796 1.21091368216169e-21 NA NA NA hsa-miR-18a-5p ATP1A3 2.04701000113742 1.30593450319289e-12 -0.412311405820062 0.216448168723333 mirMAP -0.217121380779538 0.00126156134819102 NA NA NA hsa-miR-18a-5p ATP1B2 2.04701000113742 1.30593450319289e-12 -1.64547520278281 2.43202457035088e-08 mirMAP -0.603890563978867 1.25731669581368e-27 NA NA NA hsa-miR-92a-1-5p ATP1B2 2.04820501765632 9.32117486799495e-13 -1.64547520278281 2.43202457035088e-08 MirTarget -0.51261804141802 4.05546106311406e-18 NA NA NA hsa-miR-196a-5p ATP2B2 5.05945965885472 4.48343841468539e-25 -1.88676051504383 8.01381000058104e-07 mirMAP -0.246639917243792 2.0203727718269e-08 NA NA NA hsa-miR-196b-5p ATP2B2 4.51951031652328 7.04026169031626e-18 -1.88676051504383 8.01381000058104e-07 mirMAP -0.261938730230568 1.89768791553701e-10 NA NA NA hsa-miR-21-5p ATP2B2 2.21515015440792 6.0468197386674e-49 -1.88676051504383 8.01381000058104e-07 mirMAP -0.863477449198196 1.51992957549083e-11 NA NA NA hsa-miR-335-3p ATP2B2 2.29463721765513 4.1956113745077e-18 -1.88676051504383 8.01381000058104e-07 mirMAP -0.537152874939899 4.66501969959338e-11 NA NA NA hsa-miR-135b-5p ATP2B4 2.80066701698235 2.12546333413447e-11 -0.644860700805612 0.00597426739858389 MirTarget -0.239775538861197 5.02612125577575e-13 NA NA NA hsa-miR-183-5p ATP2B4 2.08412478942637 1.08931431254487e-10 -0.644860700805612 0.00597426739858389 MirTarget;miRNATAP -0.503684880613907 1.95444123100536e-43 NA NA NA hsa-miR-21-5p ATP2B4 2.21515015440792 6.0468197386674e-49 -0.644860700805612 0.00597426739858389 miRNAWalker2_validate;MirTarget -0.49658752508725 1.53394775911162e-10 NA NA NA hsa-miR-92a-1-5p ATP2B4 2.04820501765632 9.32117486799495e-13 -0.644860700805612 0.00597426739858389 MirTarget -0.367230070920099 2.73647849040602e-15 NA NA NA hsa-miR-1-3p ATP6V1A -2.73171785118192 3.4424534921136e-12 0.341746009624906 0.000523711545672012 MirTarget -0.107361338021853 1.84531662148612e-14 NA NA NA hsa-miR-135b-5p ATP8A1 2.80066701698235 2.12546333413447e-11 -0.090064314859867 0.698857318802169 MirTarget -0.165504350942082 8.20934715339678e-07 NA NA NA hsa-miR-335-3p ATP8A2 2.29463721765513 4.1956113745077e-18 -1.33015281704727 6.49693770892505e-06 mirMAP -0.366397891135914 7.06388730590919e-09 NA NA NA hsa-miR-146b-5p ATP8B2 2.23105707690238 3.83997814011313e-23 -0.749189931878424 0.0004324878587248 miRanda -0.190071713049027 0.000361328757272574 NA NA NA hsa-miR-200a-5p ATP8B4 2.19152245759943 3.17968183522514e-11 0.114578479748931 0.513279781702399 MirTarget -0.154329520308024 4.33669750783856e-07 NA NA NA hsa-miR-335-3p ATP8B4 2.29463721765513 4.1956113745077e-18 0.114578479748931 0.513279781702399 mirMAP -0.153767750402856 3.99169270045665e-05 NA NA NA hsa-miR-146b-5p ATPAF1 2.23105707690238 3.83997814011313e-23 -0.501236072843121 8.19239900469922e-11 miRanda -0.123546078769466 1.07792982567899e-10 NA NA NA hsa-miR-146b-5p ATRNL1 2.23105707690238 3.83997814011313e-23 -1.68925010520238 1.18504412004834e-05 miRanda -0.719020200191406 1.13840463825543e-14 NA NA NA hsa-miR-192-5p ATRNL1 2.0867723747501 3.57854249239079e-08 -1.68925010520238 1.18504412004834e-05 miRNAWalker2_validate -0.332444919500384 3.2567358192866e-08 NA NA NA hsa-miR-21-5p ATRNL1 2.21515015440792 6.0468197386674e-49 -1.68925010520238 1.18504412004834e-05 MirTarget -0.873616631105802 1.01810271343051e-11 NA NA NA hsa-miR-335-3p ATRNL1 2.29463721765513 4.1956113745077e-18 -1.68925010520238 1.18504412004834e-05 MirTarget -0.560862517906509 6.42040504981108e-12 NA NA NA hsa-miR-146b-3p ATXN1 2.08650140817622 5.3293570720033e-22 -0.510555216036074 0.000257554920054182 miRNATAP -0.139221303778117 0.000135199569849613 NA NA NA hsa-miR-18a-5p ATXN1 2.04701000113742 1.30593450319289e-12 -0.510555216036074 0.000257554920054182 MirTarget;miRNATAP -0.268423373126908 6.37872406671235e-25 NA NA NA hsa-miR-200a-3p ATXN1 2.02394729844446 2.21240501925011e-08 -0.510555216036074 0.000257554920054182 MirTarget;miRNATAP -0.209779205240209 5.81767483956089e-23 NA NA NA hsa-miR-200b-3p ATXN1 2.06025765178663 3.07718049337497e-10 -0.510555216036074 0.000257554920054182 MirTarget;TargetScan -0.227285941659864 2.68913187665801e-22 NA NA NA hsa-miR-335-3p ATXN1 2.29463721765513 4.1956113745077e-18 -0.510555216036074 0.000257554920054182 mirMAP -0.198917089689175 1.23607571276296e-11 NA NA NA hsa-miR-146b-5p ATXN1L 2.23105707690238 3.83997814011313e-23 -0.0692838660654802 0.432409698959029 miRanda -0.100300155511826 3.07407592387804e-06 NA NA NA hsa-miR-18a-5p ATXN1L 2.04701000113742 1.30593450319289e-12 -0.0692838660654802 0.432409698959029 miRNATAP -0.119696275345033 1.98120954694122e-12 NA NA NA hsa-miR-200b-3p AUTS2 2.06025765178663 3.07718049337497e-10 -0.265223250836084 0.180675187907501 TargetScan -0.158666274143614 6.56372225535204e-06 NA NA NA hsa-miR-21-5p AUTS2 2.21515015440792 6.0468197386674e-49 -0.265223250836084 0.180675187907501 miRNAWalker2_validate -0.218357988341999 0.00111918037965841 NA NA NA hsa-miR-146b-5p AXL 2.23105707690238 3.83997814011313e-23 -0.192387120808621 0.351100682892 miRanda -0.155407837480721 0.00242958827427185 NA NA NA hsa-miR-192-5p B3GALNT1 2.0867723747501 3.57854249239079e-08 0.0771986442625621 0.706882769791785 miRNAWalker2_validate -0.143362281603169 6.16045930857031e-06 NA NA NA hsa-miR-335-3p B3GALNT1 2.29463721765513 4.1956113745077e-18 0.0771986442625621 0.706882769791785 MirTarget;mirMAP -0.144031252478513 0.00109588749536422 NA NA NA hsa-miR-141-5p B3GALNT2 2.13747696823946 1.73124674554872e-11 0.127784301343438 0.265417460006894 MirTarget -0.102321454822822 7.99016212592666e-07 NA NA NA hsa-miR-146b-5p B3GALT2 2.23105707690238 3.83997814011313e-23 -0.911989720058658 0.000110458267595576 miRanda -0.169288316421467 0.00441580769152182 NA NA NA hsa-miR-146b-3p B3GALT5 2.08650140817622 5.3293570720033e-22 -1.11953686297843 0.0293592036629379 MirTarget -0.269082328106087 0.0460445456091436 NA NA NA hsa-miR-21-5p B3GAT2 2.21515015440792 6.0468197386674e-49 -0.543690833886213 6.92149140549212e-05 MirTarget -0.141645325519006 0.00247439439395529 NA NA NA hsa-miR-146b-5p B4GALNT4 2.23105707690238 3.83997814011313e-23 0.22721578395652 0.669549256862328 miRanda -0.33268419211202 0.0121972286638186 NA NA NA hsa-miR-146b-3p BACE1 2.08650140817622 5.3293570720033e-22 -0.0959250699806233 0.497546427155974 miRNATAP -0.126944225890748 0.000516783528133263 NA NA NA hsa-miR-200a-3p BACE1 2.02394729844446 2.21240501925011e-08 -0.0959250699806233 0.497546427155974 mirMAP;miRNATAP -0.208936952145284 9.38264536807516e-23 NA NA NA hsa-miR-21-5p BACE1 2.21515015440792 6.0468197386674e-49 -0.0959250699806233 0.497546427155974 mirMAP -0.164453502778922 0.000553835091257011 NA NA NA hsa-miR-141-5p BACH2 2.13747696823946 1.73124674554872e-11 -0.153664361619301 0.559092317470499 miRNATAP -0.306280628052992 6.48183324255009e-11 NA NA NA hsa-miR-183-5p BACH2 2.08412478942637 1.08931431254487e-10 -0.153664361619301 0.559092317470499 MirTarget;miRNATAP -0.299221659296384 1.05026994508142e-10 NA NA NA hsa-miR-200a-3p BACH2 2.02394729844446 2.21240501925011e-08 -0.153664361619301 0.559092317470499 mirMAP -0.268978506030286 1.13035893058004e-10 NA NA NA hsa-miR-200b-3p BACH2 2.06025765178663 3.07718049337497e-10 -0.153664361619301 0.559092317470499 TargetScan;mirMAP -0.276072963555481 1.99960027856549e-09 NA NA NA hsa-miR-335-3p BACH2 2.29463721765513 4.1956113745077e-18 -0.153664361619301 0.559092317470499 mirMAP -0.296786130892161 9.59104124501261e-08 NA NA NA hsa-miR-92a-1-5p BACH2 2.04820501765632 9.32117486799495e-13 -0.153664361619301 0.559092317470499 MirTarget -0.195926401982647 0.000300824588296543 NA NA NA hsa-miR-935 BACH2 2.321600496365 1.00042201726114e-07 -0.153664361619301 0.559092317470499 PITA;miRNATAP -0.190021193538876 3.25897067992985e-07 NA NA NA hsa-miR-1-3p BAG4 -2.73171785118192 3.4424534921136e-12 0.628216551779521 1.21454572492289e-07 MirTarget -0.113793480499613 6.77277749754436e-11 NA NA NA hsa-miR-92a-1-5p BAHCC1 2.04820501765632 9.32117486799495e-13 -0.0264722536248767 0.884511725435974 mirMAP -0.104078386467178 0.00576323563770613 NA NA NA hsa-miR-21-5p BAHD1 2.21515015440792 6.0468197386674e-49 -0.130101804775212 0.132620924796786 miRNATAP -0.111899127148551 0.000109552546108838 NA NA NA hsa-miR-146b-5p BBS10 2.23105707690238 3.83997814011313e-23 -0.00841630638608315 0.958270146830151 miRanda -0.15941685680607 5.73057705478168e-05 NA NA NA hsa-miR-21-5p BBS12 2.21515015440792 6.0468197386674e-49 -0.249930684957443 0.0221008466199484 MirTarget -0.115020023297664 0.00184399882836368 NA NA NA hsa-miR-146b-5p BBS9 2.23105707690238 3.83997814011313e-23 -0.149350206803194 0.13394602894355 miRanda -0.117877010367534 1.25571684942638e-06 NA NA NA hsa-miR-18a-5p BBX 2.04701000113742 1.30593450319289e-12 0.142954198431845 0.229679690105959 MirTarget;miRNATAP -0.121309226630165 2.60236767409467e-07 NA NA NA hsa-miR-200a-3p BBX 2.02394729844446 2.21240501925011e-08 0.142954198431845 0.229679690105959 mirMAP;miRNATAP -0.111050124966782 4.56474967122374e-09 NA NA NA hsa-miR-200b-3p BBX 2.06025765178663 3.07718049337497e-10 0.142954198431845 0.229679690105959 TargetScan -0.118567696955767 1.26035634239081e-08 NA NA NA hsa-miR-335-3p BCAS1 2.29463721765513 4.1956113745077e-18 -1.2038193462543 0.00662140484790889 mirMAP -0.267762902320979 0.00543932489955407 NA NA NA hsa-miR-146b-5p BCAS3 2.23105707690238 3.83997814011313e-23 -0.324451395966981 0.00164448884736063 miRanda -0.158549778981477 2.10891617387075e-10 NA NA NA hsa-miR-146b-5p BCHE 2.23105707690238 3.83997814011313e-23 -2.60398551109055 3.72433389321808e-09 miRanda -0.930920402101123 2.41274613299009e-18 NA NA NA hsa-miR-141-5p BCKDHB 2.13747696823946 1.73124674554872e-11 -0.484588529256308 0.00034495243792206 MirTarget;miRNATAP -0.106737545949735 1.83054778190354e-05 NA NA NA hsa-miR-146b-5p BCL11A 2.23105707690238 3.83997814011313e-23 -0.932475958681757 0.00629869935051708 miRanda;miRNATAP -0.320583730602867 0.000162605713639272 NA NA NA hsa-miR-196a-5p BCL11A 5.05945965885472 4.48343841468539e-25 -0.932475958681757 0.00629869935051708 miRNAWalker2_validate -0.101812613354099 0.0100326639017667 NA NA NA hsa-miR-192-5p BCL2 2.0867723747501 3.57854249239079e-08 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate -0.219076747701746 8.11784107313729e-14 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-196b-5p BCL2 4.51951031652328 7.04026169031626e-18 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate -0.135038964160811 5.10281494563971e-11 NA NA NA hsa-miR-200a-5p BCL2 2.19152245759943 3.17968183522514e-11 -0.899142762694703 2.93311234351261e-06 mirMAP -0.27726591358478 2.73221347510694e-17 NA NA NA hsa-miR-200b-3p BCL2 2.06025765178663 3.07718049337497e-10 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase;TargetScan;mirMAP -0.26795392182203 1.0913241181438e-15 NA NA NA hsa-miR-21-5p BCL2 2.21515015440792 6.0468197386674e-49 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.40068246416158 5.43440909882672e-10 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-335-3p BCL2 2.29463721765513 4.1956113745077e-18 -0.899142762694703 2.93311234351261e-06 mirMAP -0.268016796875566 5.753163435092e-11 NA NA NA hsa-miR-133a-3p BCL2L1 -2.63342156915404 5.72661351480585e-12 0.538910243524146 0.000232226072126618 miRNAWalker2_validate -0.109066541881666 9.61762914141871e-07 23756231 Furthermore bioinformatic prediction and experimental validation were applied to identify target genes of miR-133a and the results revealed that the anti-tumor effect of miR-133a was probably due to targeting and repressing of Bcl-xL and Mcl-1 expression sarcoma hsa-miR-183-5p BCL6 2.08412478942637 1.08931431254487e-10 -0.211315139145206 0.194893611053015 miRNATAP -0.249033976913134 2.36805492395673e-19 NA NA NA hsa-miR-21-5p BCL6 2.21515015440792 6.0468197386674e-49 -0.211315139145206 0.194893611053015 miRNAWalker2_validate -0.165442720294048 0.00270909362763998 NA NA NA hsa-miR-21-5p BDH2 2.21515015440792 6.0468197386674e-49 -1.19512162130432 1.04241007480529e-13 miRNAWalker2_validate -0.275216009220252 1.05449581736892e-06 NA NA NA hsa-miR-335-3p BDH2 2.29463721765513 4.1956113745077e-18 -1.19512162130432 1.04241007480529e-13 MirTarget -0.132904608695201 0.000244281114540761 NA NA NA hsa-miR-200a-3p BEAN1 2.02394729844446 2.21240501925011e-08 0.537046321889364 0.0814216469285057 MirTarget -0.131343232839641 0.00949934538696574 NA NA NA hsa-miR-935 BEND4 2.321600496365 1.00042201726114e-07 -0.959285073111051 0.0200522339989976 mirMAP -0.134691418623725 0.024383626924723 NA NA NA hsa-miR-335-3p BEND6 2.29463721765513 4.1956113745077e-18 0.0276577166221392 0.916939806451074 mirMAP -0.269210854318478 1.79472557177128e-06 NA NA NA hsa-miR-192-5p BGLAP 2.0867723747501 3.57854249239079e-08 -0.903293918409263 8.06427733957107e-08 miRNAWalker2_validate -0.160706050932145 9.54457164408615e-10 NA NA NA hsa-miR-146b-5p BHLHB9 2.23105707690238 3.83997814011313e-23 -0.254920074784103 0.11883345498093 miRanda -0.243036918009797 7.98264198665891e-10 NA NA NA hsa-miR-200b-3p BHLHB9 2.06025765178663 3.07718049337497e-10 -0.254920074784103 0.11883345498093 mirMAP -0.143389671950974 7.09333888009856e-07 NA NA NA hsa-miR-18a-5p BHLHE22 2.04701000113742 1.30593450319289e-12 0.13885406511319 0.618764676252728 MirTarget;miRNATAP -0.339828809329708 5.52206717605423e-10 NA NA NA hsa-miR-192-5p BHLHE22 2.0867723747501 3.57854249239079e-08 0.13885406511319 0.618764676252728 MirTarget;miRNATAP -0.246135484655403 7.7184877034947e-09 NA NA NA hsa-miR-335-3p BHLHE22 2.29463721765513 4.1956113745077e-18 0.13885406511319 0.618764676252728 mirMAP -0.272399518842796 4.5866018560585e-06 NA NA NA hsa-miR-200b-3p BHLHE41 2.06025765178663 3.07718049337497e-10 0.353158422209973 0.127533936542101 MirTarget;TargetScan -0.161230519705725 9.90840208951871e-05 NA NA NA hsa-miR-200b-3p BICC1 2.06025765178663 3.07718049337497e-10 0.837229563539162 0.00140398828471014 TargetScan -0.292418835609599 2.28826204650504e-10 NA NA NA hsa-miR-194-5p BICD2 2.24386881692218 9.35116329002209e-11 -0.0193506322306654 0.886106311165939 miRNATAP -0.223771001717548 1.9507351489063e-27 NA NA NA hsa-miR-200a-3p BICD2 2.02394729844446 2.21240501925011e-08 -0.0193506322306654 0.886106311165939 MirTarget;miRNATAP -0.174967524826372 3.88689791659124e-17 NA NA NA hsa-miR-200b-3p BICD2 2.06025765178663 3.07718049337497e-10 -0.0193506322306654 0.886106311165939 TargetScan -0.168752167640922 3.48350526546594e-13 NA NA NA hsa-miR-146b-5p BMP3 2.23105707690238 3.83997814011313e-23 -2.35658001203403 0.000348108893339568 miRanda;mirMAP -1.17369996880233 1.5150418899819e-13 NA NA NA hsa-miR-21-5p BMP3 2.21515015440792 6.0468197386674e-49 -2.35658001203403 0.000348108893339568 MirTarget -1.19507443534811 6.98294198147944e-08 NA NA NA hsa-miR-935 BMP5 2.321600496365 1.00042201726114e-07 -2.89194370910152 4.76622378887106e-10 miRNATAP -0.239123565744067 0.00053366333776585 NA NA NA hsa-miR-135b-5p BMPER 2.80066701698235 2.12546333413447e-11 -2.32353300547929 8.77011175993592e-10 MirTarget -0.404263801251742 2.21363120063286e-13 NA NA NA hsa-miR-335-3p BMPER 2.29463721765513 4.1956113745077e-18 -2.32353300547929 8.77011175993592e-10 mirMAP -0.633320442339789 3.69662439745863e-15 NA NA NA hsa-miR-135b-5p BMPR1A 2.80066701698235 2.12546333413447e-11 -0.365504216704585 0.0103631845254746 MirTarget -0.117082566976443 1.08113583801423e-08 NA NA NA hsa-miR-146b-5p BMPR1B 2.23105707690238 3.83997814011313e-23 -1.24316431705201 0.00562210381774485 miRanda -0.647526314998527 3.60377268908967e-09 NA NA NA hsa-miR-192-5p BMPR2 2.0867723747501 3.57854249239079e-08 0.205986909393828 0.0634976367094706 miRNAWalker2_validate -0.101765259373634 1.64047719638657e-09 NA NA NA hsa-miR-200b-3p BMPR2 2.06025765178663 3.07718049337497e-10 0.205986909393828 0.0634976367094706 mirMAP -0.109982530187885 1.59305329887822e-08 NA NA NA hsa-miR-146b-5p BMX 2.23105707690238 3.83997814011313e-23 -1.36301267548465 7.13244454182066e-07 miRanda -0.32415830229658 2.66898601732678e-06 NA NA NA hsa-miR-146b-5p BNC1 2.23105707690238 3.83997814011313e-23 -1.62345381536263 0.000711000337305824 miRanda;miRNATAP -0.242848914736267 0.0449024114399108 NA NA NA hsa-miR-194-5p BNC1 2.24386881692218 9.35116329002209e-11 -1.62345381536263 0.000711000337305824 MirTarget -0.527640679376208 2.95892449258038e-11 NA NA NA hsa-miR-183-5p BNC2 2.08412478942637 1.08931431254487e-10 -0.491277997679328 0.0998827438687705 miRNATAP -0.612611321656216 9.33712410025636e-39 NA NA NA hsa-miR-200b-3p BNC2 2.06025765178663 3.07718049337497e-10 -0.491277997679328 0.0998827438687705 MirTarget;TargetScan -0.550025928584204 2.62751551805398e-30 NA NA NA hsa-miR-21-5p BNC2 2.21515015440792 6.0468197386674e-49 -0.491277997679328 0.0998827438687705 miRNATAP -0.360147025795031 0.0003612617211124 NA NA NA hsa-miR-194-5p BNIP2 2.24386881692218 9.35116329002209e-11 -0.0504396416676869 0.639071096410223 MirTarget -0.149492222519566 1.32493409618921e-18 NA NA NA hsa-miR-200b-3p BNIP2 2.06025765178663 3.07718049337497e-10 -0.0504396416676869 0.639071096410223 mirMAP -0.132921330276129 5.75725259874857e-13 NA NA NA hsa-miR-21-5p BOC 2.21515015440792 6.0468197386674e-49 -0.912042259856259 0.00560150824376481 miRNAWalker2_validate -0.629147771608922 9.99087704731287e-09 NA NA NA hsa-miR-146b-5p BRK1 2.23105707690238 3.83997814011313e-23 -0.564143800683483 1.26748890744613e-10 MirTarget -0.112937938232261 3.29047187572217e-07 NA NA NA hsa-miR-194-5p BRMS1L 2.24386881692218 9.35116329002209e-11 -0.0230166379516636 0.82317459332355 MirTarget -0.112409034001131 1.88258087397188e-11 NA NA NA hsa-miR-146b-3p BRSK1 2.08650140817622 5.3293570720033e-22 -0.585114914220296 0.00493904898383423 PITA;miRNATAP -0.278607420749338 1.95752319987166e-07 NA NA NA hsa-miR-135b-5p BSN 2.80066701698235 2.12546333413447e-11 -0.0926970948529537 0.75044862783081 MirTarget -0.145392650739888 0.000632584302625671 NA NA NA hsa-miR-192-5p BSN 2.0867723747501 3.57854249239079e-08 -0.0926970948529537 0.75044862783081 mirMAP -0.158917237665049 0.000465673618834625 NA NA NA hsa-miR-21-5p BTBD3 2.21515015440792 6.0468197386674e-49 -0.0957505542945336 0.50083712425855 miRNAWalker2_validate;miRNATAP -0.100655440219531 0.0369619198550155 NA NA NA hsa-miR-21-5p BTBD7 2.21515015440792 6.0468197386674e-49 -0.174009462180557 0.0347294753011317 miRNAWalker2_validate -0.103503810857852 0.000177656031075862 NA NA NA hsa-miR-21-5p BTBD9 2.21515015440792 6.0468197386674e-49 -0.171313850760551 0.0803767378404183 mirMAP -0.114898193875562 0.000486787184730028 NA NA NA hsa-miR-192-5p BTC 2.0867723747501 3.57854249239079e-08 -1.69048652094822 9.83417119475149e-10 miRNAWalker2_validate -0.255557328135743 4.99543153685461e-09 NA NA NA hsa-miR-335-3p BTC 2.29463721765513 4.1956113745077e-18 -1.69048652094822 9.83417119475149e-10 mirMAP -0.409560890137382 5.90933281940717e-12 NA NA NA hsa-miR-192-5p BTF3L4 2.0867723747501 3.57854249239079e-08 0.184476147719769 0.0505801356409219 miRNAWalker2_validate -0.100898299188196 9.16070829154608e-13 NA NA NA hsa-miR-146b-5p BTG2 2.23105707690238 3.83997814011313e-23 -1.7630923979864 5.46944077014254e-17 miRanda;miRNATAP -0.452241863518548 7.04210519721204e-18 NA NA NA hsa-miR-21-5p BTG2 2.21515015440792 6.0468197386674e-49 -1.7630923979864 5.46944077014254e-17 miRNAWalker2_validate;miRTarBase;miRNATAP -0.783413431170434 7.75255849116499e-31 24821435 miR 21 regulates N methyl N nitro N' nitrosoguanidine induced gastric tumorigenesis by targeting FASLG and BTG2 tumorigenesis gastric cancer hsa-miR-335-3p BTLA 2.29463721765513 4.1956113745077e-18 0.0691797786166884 0.843625098331528 mirMAP -0.155486272115585 0.0405290218266016 NA NA NA hsa-miR-146b-5p BVES 2.23105707690238 3.83997814011313e-23 -1.51355443880608 7.967744286549e-06 miRanda -0.679979284859576 4.95891652137777e-17 NA NA NA hsa-miR-18a-5p BVES 2.04701000113742 1.30593450319289e-12 -1.51355443880608 7.967744286549e-06 miRNAWalker2_validate -0.688278393434613 8.95261759656455e-28 NA NA NA hsa-miR-192-5p BVES 2.0867723747501 3.57854249239079e-08 -1.51355443880608 7.967744286549e-06 mirMAP -0.520118646429675 3.23387392013772e-26 NA NA NA hsa-miR-200a-3p BVES 2.02394729844446 2.21240501925011e-08 -1.51355443880608 7.967744286549e-06 mirMAP -0.607222981543812 2.85305620721598e-34 NA NA NA hsa-miR-335-3p BVES 2.29463721765513 4.1956113745077e-18 -1.51355443880608 7.967744286549e-06 mirMAP -0.686213885873242 1.06804900948749e-23 NA NA NA hsa-miR-335-3p C10orf128 2.29463721765513 4.1956113745077e-18 -0.648154615649506 0.00309002203819634 mirMAP -0.293714208854215 1.98971511401311e-10 NA NA NA hsa-miR-200a-3p C11orf21 2.02394729844446 2.21240501925011e-08 -0.14595037316475 0.656305203902004 mirMAP -0.135269535575067 0.0118788594449215 NA NA NA hsa-miR-183-5p C14orf132 2.08412478942637 1.08931431254487e-10 -1.49110797833649 1.37692195144961e-06 mirMAP -0.649230249193839 2.85151307335565e-39 NA NA NA hsa-miR-196a-5p C14orf28 5.05945965885472 4.48343841468539e-25 -0.654506740790053 1.90201722275086e-07 miRNATAP -0.104036390672796 1.7997212524641e-13 NA NA NA hsa-miR-196b-5p C14orf28 4.51951031652328 7.04026169031626e-18 -0.654506740790053 1.90201722275086e-07 miRNATAP -0.104736955671506 2.4015432389279e-15 NA NA NA hsa-miR-192-5p C15orf52 2.0867723747501 3.57854249239079e-08 -0.7749934427518 0.00649279666461122 mirMAP -0.438809942500072 3.11004754075898e-27 NA NA NA hsa-miR-141-5p C16orf52 2.13747696823946 1.73124674554872e-11 -0.0740715490056836 0.385096294799324 miRNATAP -0.109344643711846 2.32910857713509e-13 NA NA NA hsa-miR-146b-3p C17orf107 2.08650140817622 5.3293570720033e-22 -0.679094244240784 0.000611643296653501 miRNATAP -0.102807078434825 0.0492920805940206 NA NA NA hsa-miR-135b-5p C17orf51 2.80066701698235 2.12546333413447e-11 -0.238691738896759 0.168449672779437 mirMAP -0.171469375548536 2.24595268640024e-12 NA NA NA hsa-miR-200b-3p C17orf51 2.06025765178663 3.07718049337497e-10 -0.238691738896759 0.168449672779437 mirMAP -0.200064905416739 3.00795557327886e-11 NA NA NA hsa-miR-18a-5p C1QTNF1 2.04701000113742 1.30593450319289e-12 0.284534862630179 0.225915081775247 mirMAP -0.192982629819842 4.19617160466169e-05 NA NA NA hsa-miR-192-5p C1QTNF3 2.0867723747501 3.57854249239079e-08 -1.2857015633976 2.75834869264902e-05 miRNAWalker2_validate -0.375602276827499 4.31975926078151e-16 NA NA NA hsa-miR-335-3p C1QTNF7 2.29463721765513 4.1956113745077e-18 -2.02802193678542 9.32883148391431e-08 mirMAP -0.723933566868627 2.409695353988e-20 NA NA NA hsa-miR-141-5p C1orf21 2.13747696823946 1.73124674554872e-11 -0.727977288966725 9.22717896803663e-05 mirMAP -0.222776668157068 3.2755441872011e-11 NA NA NA hsa-miR-146b-5p C1orf21 2.23105707690238 3.83997814011313e-23 -0.727977288966725 9.22717896803663e-05 mirMAP -0.325007743133084 5.27173615148747e-13 NA NA NA hsa-miR-18a-5p C1orf21 2.04701000113742 1.30593450319289e-12 -0.727977288966725 9.22717896803663e-05 mirMAP -0.223487294974468 1.71224322228474e-09 NA NA NA hsa-miR-192-5p C1orf21 2.0867723747501 3.57854249239079e-08 -0.727977288966725 9.22717896803663e-05 mirMAP;miRNATAP -0.128028861703756 1.15935608612297e-05 NA NA NA hsa-miR-194-5p C1orf21 2.24386881692218 9.35116329002209e-11 -0.727977288966725 9.22717896803663e-05 mirMAP;miRNATAP -0.107152546992702 0.000762449880295651 NA NA NA hsa-miR-200a-3p C1orf21 2.02394729844446 2.21240501925011e-08 -0.727977288966725 9.22717896803663e-05 miRNATAP -0.201515180996121 1.35488315151594e-11 NA NA NA hsa-miR-335-3p C1orf21 2.29463721765513 4.1956113745077e-18 -0.727977288966725 9.22717896803663e-05 mirMAP -0.194498040789708 1.21974617116637e-06 NA NA NA hsa-miR-200a-3p C20orf194 2.02394729844446 2.21240501925011e-08 -0.718628311945438 0.00134969243858786 mirMAP -0.357822760950243 1.87484869859019e-26 NA NA NA hsa-miR-335-3p C21orf91 2.29463721765513 4.1956113745077e-18 -0.283004652780939 0.0186853434311133 mirMAP -0.110302195113083 1.80002299452811e-05 NA NA NA hsa-miR-141-5p C2CD2 2.13747696823946 1.73124674554872e-11 -0.0695744093806967 0.535515698693416 MirTarget -0.105444775050748 1.82008500336455e-07 NA NA NA hsa-miR-935 C2orf88 2.321600496365 1.00042201726114e-07 -1.5200278010868 1.04991367215236e-08 miRNATAP -0.163821862868022 2.70883668840797e-05 NA NA NA hsa-miR-335-3p C4orf3 2.29463721765513 4.1956113745077e-18 -0.897932651956413 1.09962586318821e-14 mirMAP -0.173976477924679 7.93214002409752e-12 NA NA NA hsa-miR-335-3p C4orf32 2.29463721765513 4.1956113745077e-18 -0.551325207693953 4.33159522051256e-05 mirMAP -0.151730307579161 1.52678547459492e-07 NA NA NA hsa-miR-141-5p C5orf24 2.13747696823946 1.73124674554872e-11 0.0777724257584538 0.410658063162808 miRNATAP -0.102437503427152 1.14026389374917e-09 NA NA NA hsa-miR-335-3p C5orf63 2.29463721765513 4.1956113745077e-18 -0.475314748890798 0.0170643514908196 mirMAP -0.110852603400721 0.010306517937644 NA NA NA hsa-miR-146b-5p C6 2.23105707690238 3.83997814011313e-23 -1.59496022974437 0.00103166904301099 miRanda -0.279624685134794 0.0224500639704696 NA NA NA hsa-miR-335-3p C8orf34 2.29463721765513 4.1956113745077e-18 -0.944740590541771 6.04998040363357e-05 mirMAP -0.204462884682879 6.4061311007901e-05 NA NA NA hsa-miR-192-5p C9orf47 2.0867723747501 3.57854249239079e-08 -0.537474826688319 0.0750707133557038 mirMAP -0.427335837055336 1.37915480736666e-22 NA NA NA hsa-miR-335-3p CA5B 2.29463721765513 4.1956113745077e-18 -0.0659463723940039 0.65343650265455 mirMAP -0.181933399724378 3.51185216240884e-09 NA NA NA hsa-miR-935 CA5B 2.321600496365 1.00042201726114e-07 -0.0659463723940039 0.65343650265455 mirMAP -0.122231411719169 2.68216746519123e-09 NA NA NA hsa-miR-192-5p CAB39L 2.0867723747501 3.57854249239079e-08 -1.76562312798893 2.94345232906232e-14 miRNAWalker2_validate -0.397869047418757 1.92670095418945e-31 NA NA NA hsa-miR-200b-3p CACHD1 2.06025765178663 3.07718049337497e-10 -0.320745871977507 0.138986353847716 TargetScan -0.135520209219911 0.000484461288319484 NA NA NA hsa-miR-18a-5p CACNA1B 2.04701000113742 1.30593450319289e-12 -0.460774721329853 0.312833052039832 mirMAP -0.453926796368506 5.89085812801978e-07 NA NA NA hsa-miR-200a-3p CACNA1B 2.02394729844446 2.21240501925011e-08 -0.460774721329853 0.312833052039832 mirMAP -0.452066747743248 4.99584175735159e-10 NA NA NA hsa-miR-335-3p CACNA1B 2.29463721765513 4.1956113745077e-18 -0.460774721329853 0.312833052039832 mirMAP -0.270543651861205 0.00608149711206899 NA NA NA hsa-miR-192-5p CACNA1C 2.0867723747501 3.57854249239079e-08 -0.182409901963044 0.557004423318687 mirMAP -0.406535239457594 3.85164964724922e-19 NA NA NA hsa-miR-200b-3p CACNA1C 2.06025765178663 3.07718049337497e-10 -0.182409901963044 0.557004423318687 MirTarget;TargetScan -0.534302005247156 7.19545908944889e-26 NA NA NA hsa-miR-141-5p CACNA1E 2.13747696823946 1.73124674554872e-11 1.7522562120673 4.35724222478899e-06 mirMAP -0.162699029558984 0.023568693432398 NA NA NA hsa-miR-200a-3p CACNA1E 2.02394729844446 2.21240501925011e-08 1.7522562120673 4.35724222478899e-06 MirTarget;miRNATAP -0.16717476820364 0.00874140728106229 NA NA NA hsa-miR-200b-3p CACNA2D1 2.06025765178663 3.07718049337497e-10 -0.846445244760543 0.00675290229856498 TargetScan -0.42715161103858 1.77599163924932e-15 NA NA NA hsa-miR-335-3p CACNA2D1 2.29463721765513 4.1956113745077e-18 -0.846445244760543 0.00675290229856498 mirMAP -0.424102056619092 1.11139662309494e-10 NA NA NA hsa-miR-935 CACNA2D2 2.321600496365 1.00042201726114e-07 -1.23906771692005 3.22520231482914e-06 PITA;miRNATAP -0.241416813559694 1.86371709587043e-10 NA NA NA hsa-miR-146b-3p CACNB2 2.08650140817622 5.3293570720033e-22 -1.05668882228159 0.000454628609880799 miRNATAP -0.510270701370925 2.83123310358038e-11 NA NA NA hsa-miR-146b-5p CACNB4 2.23105707690238 3.83997814011313e-23 -1.05630266128413 0.000199554767655941 miRanda -0.259896350620175 0.000261715990026198 NA NA NA hsa-miR-183-5p CACNB4 2.08412478942637 1.08931431254487e-10 -1.05630266128413 0.000199554767655941 miRNATAP -0.342579971003353 1.12137938868722e-11 NA NA NA hsa-miR-196a-5p CACNB4 5.05945965885472 4.48343841468539e-25 -1.05630266128413 0.000199554767655941 miRNATAP -0.106586458946572 0.00122490155652018 NA NA NA hsa-miR-196b-5p CACNB4 4.51951031652328 7.04026169031626e-18 -1.05630266128413 0.000199554767655941 miRNATAP -0.123111664113669 6.93648264078018e-05 NA NA NA hsa-miR-335-3p CACNB4 2.29463721765513 4.1956113745077e-18 -1.05630266128413 0.000199554767655941 mirMAP -0.254668172234139 3.45322376865642e-05 NA NA NA hsa-miR-18a-5p CACNG4 2.04701000113742 1.30593450319289e-12 -0.704985062832737 0.198151889739357 mirMAP -0.402980657463614 0.000259826359094672 NA NA NA hsa-miR-146b-5p CADM1 2.23105707690238 3.83997814011313e-23 -0.899936241890849 0.000844138987328649 PITA;miRanda -0.348755468790563 1.58261001691632e-07 NA NA NA hsa-miR-192-5p CADM1 2.0867723747501 3.57854249239079e-08 -0.899936241890849 0.000844138987328649 miRNAWalker2_validate -0.255287068605976 7.16867093595076e-10 NA NA NA hsa-miR-194-5p CADM1 2.24386881692218 9.35116329002209e-11 -0.899936241890849 0.000844138987328649 miRNATAP -0.279729895418736 4.22839437836686e-10 NA NA NA hsa-miR-200a-3p CADM1 2.02394729844446 2.21240501925011e-08 -0.899936241890849 0.000844138987328649 MirTarget -0.240702827116703 3.49040607144267e-08 NA NA NA hsa-miR-200b-3p CADM1 2.06025765178663 3.07718049337497e-10 -0.899936241890849 0.000844138987328649 TargetScan -0.262479616962518 4.3464640649513e-08 NA NA NA hsa-miR-335-3p CADM1 2.29463721765513 4.1956113745077e-18 -0.899936241890849 0.000844138987328649 mirMAP -0.274919283509269 2.08270361341812e-06 NA NA NA hsa-miR-146b-5p CADM2 2.23105707690238 3.83997814011313e-23 -3.78218788728738 1.41764228771757e-12 miRanda -1.10487872258102 4.07395605068169e-17 NA NA NA hsa-miR-196a-5p CADM2 5.05945965885472 4.48343841468539e-25 -3.78218788728738 1.41764228771757e-12 miRNATAP -0.426774753967281 5.74097781383702e-12 NA NA NA hsa-miR-196b-5p CADM2 4.51951031652328 7.04026169031626e-18 -3.78218788728738 1.41764228771757e-12 miRNATAP -0.446413107713315 1.15308473612407e-14 NA NA NA hsa-miR-200a-3p CADM2 2.02394729844446 2.21240501925011e-08 -3.78218788728738 1.41764228771757e-12 miRNATAP -0.82197904147792 2.57574712786718e-22 NA NA NA hsa-miR-21-5p CADM2 2.21515015440792 6.0468197386674e-49 -3.78218788728738 1.41764228771757e-12 mirMAP;miRNATAP -1.39254609202924 1.3520773728452e-14 NA NA NA hsa-miR-335-3p CADM2 2.29463721765513 4.1956113745077e-18 -3.78218788728738 1.41764228771757e-12 mirMAP -1.08867159273415 1.41622433757594e-22 NA NA NA hsa-miR-135b-5p CADM3 2.80066701698235 2.12546333413447e-11 -3.66297336185573 5.94251947168831e-13 MirTarget -0.687235464074121 2.69306835409743e-21 NA NA NA hsa-miR-335-3p CADM4 2.29463721765513 4.1956113745077e-18 -0.635412537357027 0.00305336589176558 MirTarget -0.129752207336398 0.00537239134741782 NA NA NA hsa-miR-935 CADPS 2.321600496365 1.00042201726114e-07 -0.793309503743872 0.113063005995695 PITA -0.332188397639928 3.17525561761705e-06 NA NA NA hsa-miR-935 CALCOCO1 2.321600496365 1.00042201726114e-07 -0.872748383280905 5.07183818239062e-10 miRNATAP -0.167594028259781 1.56909521863604e-17 NA NA NA hsa-miR-146b-5p CALD1 2.23105707690238 3.83997814011313e-23 -0.498524803482272 0.0854448127355164 miRanda -0.417274011817819 3.20431856390727e-09 NA NA NA hsa-miR-196a-5p CALD1 5.05945965885472 4.48343841468539e-25 -0.498524803482272 0.0854448127355164 MirTarget -0.207188337874161 1.54429998906283e-10 NA NA NA hsa-miR-196b-5p CALD1 4.51951031652328 7.04026169031626e-18 -0.498524803482272 0.0854448127355164 MirTarget -0.232908562385621 8.2122855615416e-15 NA NA NA hsa-miR-21-5p CALD1 2.21515015440792 6.0468197386674e-49 -0.498524803482272 0.0854448127355164 miRNAWalker2_validate;MirTarget -0.474696767410786 9.91339917127746e-07 NA NA NA hsa-miR-200a-3p CALM1 2.02394729844446 2.21240501925011e-08 -0.784429149792681 2.03164806777006e-14 mirMAP -0.115674467121116 1.02438358754888e-11 NA NA NA hsa-miR-141-5p CAMK1 2.13747696823946 1.73124674554872e-11 -0.313073666504854 0.0221607303055769 MirTarget -0.211315075268973 3.65094014838385e-19 NA NA NA hsa-miR-141-5p CAMK1D 2.13747696823946 1.73124674554872e-11 -0.706084424822242 0.00255002971247588 mirMAP -0.311543138840718 6.24395797657749e-14 NA NA NA hsa-miR-200b-3p CAMK1D 2.06025765178663 3.07718049337497e-10 -0.706084424822242 0.00255002971247588 mirMAP -0.34774301162508 2.25868303062112e-18 NA NA NA hsa-miR-146b-3p CAMK2A 2.08650140817622 5.3293570720033e-22 -1.10946652714049 0.00204119457772691 miRNATAP -0.514934647751306 2.53381652999357e-08 NA NA NA hsa-miR-18a-5p CAMK2B 2.04701000113742 1.30593450319289e-12 -2.34482039839898 5.64095834233735e-09 mirMAP -0.328350190786899 8.14906622742488e-05 NA NA NA hsa-miR-194-5p CAMK2G 2.24386881692218 9.35116329002209e-11 -0.531707953024434 0.000413134284231954 miRNATAP -0.154031309366531 7.39377580924271e-10 NA NA NA hsa-miR-146b-3p CAMK2N1 2.08650140817622 5.3293570720033e-22 0.37204973643202 0.160778006480799 PITA -0.162585952407612 0.0189638854987613 NA NA NA hsa-miR-135b-5p CAMK4 2.80066701698235 2.12546333413447e-11 -0.596232499132412 0.011832094031569 MirTarget -0.196043143310703 8.75550937609683e-09 NA NA NA hsa-miR-141-5p CAMK4 2.13747696823946 1.73124674554872e-11 -0.596232499132412 0.011832094031569 mirMAP -0.177805701354442 4.35359304123944e-05 NA NA NA hsa-miR-192-5p CAMK4 2.0867723747501 3.57854249239079e-08 -0.596232499132412 0.011832094031569 miRNAWalker2_validate -0.100142787955831 0.00723122161813675 NA NA NA hsa-miR-200a-3p CAMK4 2.02394729844446 2.21240501925011e-08 -0.596232499132412 0.011832094031569 mirMAP -0.16279198343063 2.4920056404688e-05 NA NA NA hsa-miR-200a-5p CAMK4 2.19152245759943 3.17968183522514e-11 -0.596232499132412 0.011832094031569 mirMAP -0.166551940867988 7.12613219049604e-05 NA NA NA hsa-miR-21-5p CAMK4 2.21515015440792 6.0468197386674e-49 -0.596232499132412 0.011832094031569 mirMAP -0.23786185409185 0.00318399111889911 NA NA NA hsa-miR-335-3p CAMK4 2.29463721765513 4.1956113745077e-18 -0.596232499132412 0.011832094031569 MirTarget;mirMAP -0.270297063362408 7.98486098528927e-08 NA NA NA hsa-miR-935 CAMK4 2.321600496365 1.00042201726114e-07 -0.596232499132412 0.011832094031569 mirMAP -0.126542624548502 0.000204325126539197 NA NA NA hsa-miR-146b-5p CAMLG 2.23105707690238 3.83997814011313e-23 -0.480230958584 3.19005000071531e-06 miRanda -0.101696513926023 8.2814444216842e-05 NA NA NA hsa-miR-200a-3p CAMSAP2 2.02394729844446 2.21240501925011e-08 0.423832054082736 0.000532909035924399 MirTarget;miRNATAP -0.117555370999083 2.20951466630983e-09 NA NA NA hsa-miR-200b-3p CAMSAP2 2.06025765178663 3.07718049337497e-10 0.423832054082736 0.000532909035924399 MirTarget;TargetScan -0.116070704028349 9.08905666331661e-08 NA NA NA hsa-miR-1-3p CAND1 -2.73171785118192 3.4424534921136e-12 0.404447093370241 0.000129508898109157 miRTarBase -0.110520366094798 3.07016260270459e-13 NA NA NA hsa-miR-335-3p CAP2 2.29463721765513 4.1956113745077e-18 -0.971626306757137 0.00283651835875282 mirMAP -0.490353696421385 5.24351259836264e-13 NA NA NA hsa-miR-146b-5p CAPS 2.23105707690238 3.83997814011313e-23 -0.654865237778581 0.0344454175841112 miRanda -0.382043269508581 5.16820907436339e-07 NA NA NA hsa-miR-146b-5p CAPS2 2.23105707690238 3.83997814011313e-23 -0.383521142725705 0.0639666467325194 miRanda -0.130697159014091 0.01146650110887 NA NA NA hsa-miR-200b-3p CASD1 2.06025765178663 3.07718049337497e-10 -0.0564635591512928 0.674318190720727 TargetScan -0.144246407370863 7.01726340330353e-10 NA NA NA hsa-miR-1-3p CASK -2.73171785118192 3.4424534921136e-12 0.893258002519737 2.03825794521693e-11 MirTarget -0.13086632037314 4.71871317636911e-11 NA NA NA hsa-miR-146b-5p CASR 2.23105707690238 3.83997814011313e-23 -2.33409213947677 3.76223136498127e-06 miRanda -0.256715993212559 0.0459917208549061 26178670 miR 135b and miR 146b dependent silencing of calcium sensing receptor expression in colorectal tumors; Inhibition of miR-135b and miR-146b expression led to high CaSR levels and significantly reduced proliferation; In samples of colorectal tumors we observed overexpression of miR-135b and miR-146b and this correlated inversely with CaSR expression miR-135b: r = -0.684 p < 0.001 and miR-146b: r = -0.448 p < 0.001 supporting our in vitro findings; We demonstrate that miR-135b and miR-146b target the CaSR and reduce its expression in colorectal tumors reducing the antiproliferative and prodifferentiating actions of calcium colorectal cancer hsa-miR-146b-5p CASZ1 2.23105707690238 3.83997814011313e-23 -0.74282009313037 2.13443263629592e-07 miRanda;miRNATAP -0.260274712853446 8.05077559801873e-14 NA NA NA hsa-miR-18a-5p CASZ1 2.04701000113742 1.30593450319289e-12 -0.74282009313037 2.13443263629592e-07 mirMAP -0.133981279350177 4.55857172266144e-06 NA NA NA hsa-miR-146b-5p CAT 2.23105707690238 3.83997814011313e-23 -0.779073249144004 2.67783754686251e-10 miRanda -0.172145289026977 2.97331062205996e-08 NA NA NA hsa-miR-335-3p CAV2 2.29463721765513 4.1956113745077e-18 -0.271192570065327 0.242473310137218 mirMAP -0.184751440237261 0.000206902126589645 NA NA NA hsa-miR-196a-5p CBFA2T3 5.05945965885472 4.48343841468539e-25 -1.22133105486193 6.89171725275405e-06 MirTarget;miRNATAP -0.151261344364969 1.38306732206054e-06 NA NA NA hsa-miR-196b-5p CBFA2T3 4.51951031652328 7.04026169031626e-18 -1.22133105486193 6.89171725275405e-06 MirTarget;miRNATAP -0.15754001812114 8.48878340452173e-08 NA NA NA hsa-miR-335-3p CBFA2T3 2.29463721765513 4.1956113745077e-18 -1.22133105486193 6.89171725275405e-06 MirTarget -0.42761237715908 6.59709371374494e-14 NA NA NA hsa-miR-935 CBLN4 2.321600496365 1.00042201726114e-07 0.517923288433926 0.261553190533659 MirTarget -0.137845100065695 0.0387829233438813 NA NA NA hsa-miR-335-3p CBR4 2.29463721765513 4.1956113745077e-18 -0.321356447145465 0.00664140114952099 mirMAP -0.137957003732443 3.7103284583135e-08 NA NA NA hsa-miR-194-5p CBX5 2.24386881692218 9.35116329002209e-11 0.164944902002406 0.244455396933291 mirMAP -0.132851376448075 1.39572402132684e-08 NA NA NA hsa-miR-200b-3p CBX5 2.06025765178663 3.07718049337497e-10 0.164944902002406 0.244455396933291 TargetScan -0.104982650310067 3.08865043207079e-05 NA NA NA hsa-miR-146b-5p CBX6 2.23105707690238 3.83997814011313e-23 -0.518068180043437 0.0350577744444793 miRanda -0.349612141937403 5.27590499974884e-09 NA NA NA hsa-miR-183-5p CBX6 2.08412478942637 1.08931431254487e-10 -0.518068180043437 0.0350577744444793 mirMAP -0.385492454218897 2.64270810708309e-20 NA NA NA hsa-miR-92a-1-5p CBX6 2.04820501765632 9.32117486799495e-13 -0.518068180043437 0.0350577744444793 mirMAP -0.245587625099305 1.06291052935498e-06 NA NA NA hsa-miR-146b-3p CBX7 2.08650140817622 5.3293570720033e-22 -1.45014623127943 2.0707194630395e-12 miRNATAP -0.447125076188972 3.04787853734584e-17 NA NA NA hsa-miR-146b-5p CBX7 2.23105707690238 3.83997814011313e-23 -1.45014623127943 2.0707194630395e-12 mirMAP -0.46093366863956 2.97748697796511e-20 NA NA NA hsa-miR-146b-5p CBY1 2.23105707690238 3.83997814011313e-23 -0.512111972982919 4.58204989919408e-07 miRanda -0.141772847831954 1.72218213611593e-08 NA NA NA hsa-miR-335-3p CC2D2A 2.29463721765513 4.1956113745077e-18 -1.04767448059478 2.0057907476736e-06 mirMAP -0.325753887978598 3.0673191875494e-12 NA NA NA hsa-miR-335-3p CC2D2B 2.29463721765513 4.1956113745077e-18 0.0958506019423244 0.690082707356461 mirMAP -0.164346063895805 0.00148221828376976 NA NA NA hsa-miR-21-5p CCDC121 2.21515015440792 6.0468197386674e-49 -0.275928877337091 0.0120094005042238 MirTarget -0.148182745343142 6.11495453584177e-05 NA NA NA hsa-miR-335-3p CCDC121 2.29463721765513 4.1956113745077e-18 -0.275928877337091 0.0120094005042238 mirMAP -0.101835932311331 1.42421625791631e-05 NA NA NA hsa-miR-335-3p CCDC141 2.29463721765513 4.1956113745077e-18 -0.00290260958293398 0.992193217819001 mirMAP -0.141177362413714 0.0277623122602731 NA NA NA hsa-miR-200a-5p CCDC144A 2.19152245759943 3.17968183522514e-11 -0.223988875692845 0.668368573068086 mirMAP -0.215091975668568 0.0207711666938084 NA NA NA hsa-miR-146b-5p CCDC146 2.23105707690238 3.83997814011313e-23 -0.989090208793832 1.08003699601719e-05 miRanda -0.32685632836082 3.85054601078996e-09 NA NA NA hsa-miR-192-5p CCDC152 2.0867723747501 3.57854249239079e-08 -1.55013277951463 2.86627689686247e-09 miRNATAP -0.122535721475266 0.00366200226470666 NA NA NA hsa-miR-21-5p CCDC152 2.21515015440792 6.0468197386674e-49 -1.55013277951463 2.86627689686247e-09 mirMAP -0.543671515085362 9.5912134092705e-10 NA NA NA hsa-miR-146b-5p CCDC36 2.23105707690238 3.83997814011313e-23 0.00891246875786411 0.971047757134715 miRanda -0.129224233044274 0.034904599095461 NA NA NA hsa-miR-335-3p CCDC39 2.29463721765513 4.1956113745077e-18 0.126193778053742 0.620044829230302 mirMAP -0.154870326425663 0.00477140749470352 NA NA NA hsa-miR-146b-5p CCDC50 2.23105707690238 3.83997814011313e-23 -0.207892131942541 0.0906382801215107 miRanda -0.117176182345706 0.000111378561240829 NA NA NA hsa-miR-335-3p CCDC50 2.29463721765513 4.1956113745077e-18 -0.207892131942541 0.0906382801215107 MirTarget;mirMAP -0.143600845139774 2.9430145494953e-08 NA NA NA hsa-miR-935 CCDC50 2.321600496365 1.00042201726114e-07 -0.207892131942541 0.0906382801215107 mirMAP -0.114661912807401 1.74319114793637e-11 NA NA NA hsa-miR-192-5p CCDC69 2.0867723747501 3.57854249239079e-08 -1.92147212670969 5.06729452013324e-13 mirMAP -0.413294698023504 3.4206028711601e-25 NA NA NA hsa-miR-335-3p CCDC69 2.29463721765513 4.1956113745077e-18 -1.92147212670969 5.06729452013324e-13 mirMAP -0.609548375410076 1.44331047770229e-29 NA NA NA hsa-miR-200a-3p CCDC80 2.02394729844446 2.21240501925011e-08 -0.395086111194338 0.247730855287492 MirTarget -0.562632719290802 5.39733961755242e-29 NA NA NA hsa-miR-335-3p CCDC80 2.29463721765513 4.1956113745077e-18 -0.395086111194338 0.247730855287492 mirMAP -0.363527006219919 5.57576218612408e-07 NA NA NA hsa-miR-146b-5p CCDC85A 2.23105707690238 3.83997814011313e-23 -0.856107401010904 0.000616831555413395 miRanda -0.328579276847498 9.88620864210592e-08 NA NA NA hsa-miR-18a-5p CCDC88A 2.04701000113742 1.30593450319289e-12 0.423977013344125 0.0199852655793849 miRNATAP -0.123788903125374 0.000776771965592341 NA NA NA hsa-miR-200a-5p CCDC88A 2.19152245759943 3.17968183522514e-11 0.423977013344125 0.0199852655793849 miRNATAP -0.199265131389654 2.44728765763757e-10 NA NA NA hsa-miR-146b-5p CCDC89 2.23105707690238 3.83997814011313e-23 -0.656497996259702 0.00395035634475869 miRanda -0.281626110429065 5.29484185405445e-07 NA NA NA hsa-miR-146b-5p CCK 2.23105707690238 3.83997814011313e-23 -2.80270348088655 6.75125146243396e-07 MirTarget;PITA;miRanda;miRNATAP -0.611118918042646 1.74160538393532e-05 NA NA NA hsa-miR-335-3p CCL11 2.29463721765513 4.1956113745077e-18 -1.19113207829955 0.000670435868910084 MirTarget -0.359273256691433 1.82714492578277e-06 NA NA NA hsa-miR-183-5p CCND2 2.08412478942637 1.08931431254487e-10 -0.266828347557643 0.311200298179232 miRNATAP -0.315775206761385 8.35703763428762e-12 NA NA NA hsa-miR-200a-3p CCND2 2.02394729844446 2.21240501925011e-08 -0.266828347557643 0.311200298179232 MirTarget -0.219287797903635 2.3044254482718e-07 NA NA NA hsa-miR-335-3p CCNDBP1 2.29463721765513 4.1956113745077e-18 -0.866464859452312 2.13742339576552e-20 MirTarget -0.156954458106881 3.6674073633208e-14 NA NA NA hsa-miR-21-5p CCNG1 2.21515015440792 6.0468197386674e-49 -0.702987782947956 5.39693567551696e-07 miRNAWalker2_validate -0.160860427066878 0.000886365792680893 NA NA NA hsa-miR-146b-3p CCNJL 2.08650140817622 5.3293570720033e-22 -0.802704504379545 0.000280565575577219 MirTarget -0.172426837309699 0.00301369159629613 NA NA NA hsa-miR-335-3p CCPG1 2.29463721765513 4.1956113745077e-18 -0.206345981982444 0.045354236212813 MirTarget -0.160470365704697 3.58970887991371e-14 NA NA NA hsa-miR-135b-5p CD109 2.80066701698235 2.12546333413447e-11 0.258681502538528 0.31950123858526 mirMAP -0.156349151422686 3.46725708196499e-05 NA NA NA hsa-miR-141-5p CD109 2.13747696823946 1.73124674554872e-11 0.258681502538528 0.31950123858526 MirTarget -0.331823832262864 5.10374704283368e-13 NA NA NA hsa-miR-335-3p CD160 2.29463721765513 4.1956113745077e-18 -0.775915727004627 8.27988295810442e-05 mirMAP -0.118458601952009 0.00598980972873235 NA NA NA hsa-miR-335-3p CD180 2.29463721765513 4.1956113745077e-18 -0.0902115577234657 0.753625240515514 MirTarget -0.192574939721567 0.00185613719979267 NA NA NA hsa-miR-146b-5p CD36 2.23105707690238 3.83997814011313e-23 -2.04248186649953 2.72888979141343e-13 miRanda -0.273922825061767 0.000162176869390771 NA NA NA hsa-miR-200a-3p CD59 2.02394729844446 2.21240501925011e-08 -0.734403747895271 1.70762518848825e-07 mirMAP -0.129776523908242 1.66736182828775e-08 NA NA NA hsa-miR-335-3p CD59 2.29463721765513 4.1956113745077e-18 -0.734403747895271 1.70762518848825e-07 mirMAP -0.222057428841265 6.59943151160997e-14 NA NA NA hsa-miR-335-3p CD93 2.29463721765513 4.1956113745077e-18 0.555286535237983 0.000952282124515786 mirMAP -0.107846260937175 0.00314778315203846 NA NA NA hsa-miR-146b-5p CDADC1 2.23105707690238 3.83997814011313e-23 -0.175403878216009 0.0980480368715214 miRanda -0.111721644912025 1.77624650868453e-05 NA NA NA hsa-miR-335-3p CDC37L1 2.29463721765513 4.1956113745077e-18 -0.427242848422614 9.3988336440429e-05 MirTarget;mirMAP -0.132242044763132 1.32180388170204e-08 NA NA NA hsa-miR-141-5p CDC42BPA 2.13747696823946 1.73124674554872e-11 -0.0510667181777871 0.739167207070263 miRNATAP -0.118766723683298 2.09006234257907e-05 NA NA NA hsa-miR-146b-5p CDC42BPA 2.23105707690238 3.83997814011313e-23 -0.0510667181777871 0.739167207070263 miRNATAP -0.16530799105045 1.13805610149716e-05 NA NA NA hsa-miR-146b-5p CDC42EP3 2.23105707690238 3.83997814011313e-23 -0.123901712398209 0.566980171516008 miRanda -0.26350007796914 6.51937407853458e-07 NA NA NA hsa-miR-200a-3p CDC42EP3 2.02394729844446 2.21240501925011e-08 -0.123901712398209 0.566980171516008 MirTarget -0.34435824871446 7.35020970127168e-27 NA NA NA hsa-miR-200b-3p CDC42EP3 2.06025765178663 3.07718049337497e-10 -0.123901712398209 0.566980171516008 TargetScan -0.372934006694852 5.07814006443935e-26 NA NA NA hsa-miR-335-3p CDC42EP3 2.29463721765513 4.1956113745077e-18 -0.123901712398209 0.566980171516008 mirMAP -0.276239889350999 1.15686638463215e-09 NA NA NA hsa-miR-92a-1-5p CDC42EP3 2.04820501765632 9.32117486799495e-13 -0.123901712398209 0.566980171516008 MirTarget -0.25388441705003 6.35479053439497e-09 NA NA NA hsa-miR-146b-3p CDCA7L 2.08650140817622 5.3293570720033e-22 -0.0907282453801574 0.638789262380265 MirTarget;PITA -0.17444589720844 0.000490749068843464 NA NA NA hsa-miR-146b-5p CDH10 2.23105707690238 3.83997814011313e-23 -2.39732639624343 1.15019585560212e-06 miRanda -0.669746871171129 5.00770427724115e-08 NA NA NA hsa-miR-200b-3p CDH11 2.06025765178663 3.07718049337497e-10 1.42671930314161 2.20201589928761e-10 TargetScan -0.2017247638054 1.02741801913574e-06 NA NA NA hsa-miR-141-5p CDH19 2.13747696823946 1.73124674554872e-11 -3.43443959474682 8.25462091308429e-10 MirTarget -1.02083383617697 8.27613123448842e-26 NA NA NA hsa-miR-194-5p CDH2 2.24386881692218 9.35116329002209e-11 -0.676171143790671 0.0404221186379083 miRNAWalker2_validate;miRTarBase;miRNATAP -0.382377018680577 1.30645514844207e-12 21845495;20979124 The results of real-time PCR and western blot highlighted that miR-194 interacted with N-cadherin and negatively regulated its expression at the translational level;The overexpression of miR-194 in liver mesenchymal-like cancer cells reduced the expression of the mesenchymal cell marker N-cadherin and suppressed invasion and migration of the mesenchymal-like cancer cells both in vitro and in vivo ; gastric cancer;liver cancer hsa-miR-146b-3p CDH23 2.08650140817622 5.3293570720033e-22 -0.974388320574098 0.000335337548802092 mirMAP -0.229718056348532 0.00128925233418746 NA NA NA hsa-miR-335-3p CDH26 2.29463721765513 4.1956113745077e-18 -0.764586765850729 0.00633489210251582 mirMAP -0.238514581094071 7.78988691823342e-05 NA NA NA hsa-miR-135b-5p CDHR1 2.80066701698235 2.12546333413447e-11 -1.79298627070723 0.000196320849497967 mirMAP -0.229610435446218 0.00128716799359844 NA NA NA hsa-miR-146b-5p CDHR1 2.23105707690238 3.83997814011313e-23 -1.79298627070723 0.000196320849497967 miRanda -0.384616756761555 0.00150064563820845 NA NA NA hsa-miR-146b-5p CDHR3 2.23105707690238 3.83997814011313e-23 -0.977207620156484 3.65000460373316e-05 miRanda -0.424979371274422 1.10979461610192e-13 NA NA NA hsa-miR-192-5p CDK14 2.0867723747501 3.57854249239079e-08 -0.300429156166662 0.186723710515312 miRNAWalker2_validate -0.238436217082729 3.67128683954332e-12 NA NA NA hsa-miR-194-5p CDK14 2.24386881692218 9.35116329002209e-11 -0.300429156166662 0.186723710515312 MirTarget -0.255046033172563 6.84039685364144e-12 NA NA NA hsa-miR-335-3p CDK14 2.29463721765513 4.1956113745077e-18 -0.300429156166662 0.186723710515312 MirTarget -0.279225141820882 5.68745553151237e-09 NA NA NA hsa-miR-200a-3p CDK17 2.02394729844446 2.21240501925011e-08 0.0694540025336501 0.487075282749813 MirTarget;miRNATAP -0.1203415464173 7.65180992481249e-15 NA NA NA hsa-miR-200b-3p CDK17 2.06025765178663 3.07718049337497e-10 0.0694540025336501 0.487075282749813 MirTarget;TargetScan -0.122045467525224 1.10168728267942e-12 NA NA NA hsa-miR-194-5p CDK5R2 2.24386881692218 9.35116329002209e-11 -1.28146865750589 0.0116632319279761 mirMAP -0.191604620067408 0.0273311364835671 NA NA NA hsa-miR-146b-5p CDKL2 2.23105707690238 3.83997814011313e-23 -1.16074814091993 0.00181856090352479 miRanda -0.687913460496004 1.13194827744315e-14 NA NA NA hsa-miR-335-3p CDKL2 2.29463721765513 4.1956113745077e-18 -1.16074814091993 0.00181856090352479 MirTarget -0.474103634614959 1.87557130096969e-09 NA NA NA hsa-miR-146b-5p CDKN1A 2.23105707690238 3.83997814011313e-23 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate -0.215180106045082 3.12241828598735e-06 27602131 During the search for potential targets of miR-146b in ATC p21 also known as p21Waf1/Cip1 or CDKN1A was noted for its role in cell cycle progression and tumor pathogenesis progression thyroid cancer hsa-miR-141-5p CDO1 2.13747696823946 1.73124674554872e-11 -1.79977725795826 7.33199668734239e-06 MirTarget -0.711796382718703 4.34145123309886e-25 NA NA NA hsa-miR-146b-5p CDON 2.23105707690238 3.83997814011313e-23 -0.742711204088021 0.0145188883462419 miRanda;mirMAP;miRNATAP -0.483373623001299 4.94176458012156e-11 NA NA NA hsa-miR-18a-5p CDON 2.04701000113742 1.30593450319289e-12 -0.742711204088021 0.0145188883462419 mirMAP -0.472996791936891 6.3403191804327e-16 NA NA NA hsa-miR-192-5p CDON 2.0867723747501 3.57854249239079e-08 -0.742711204088021 0.0145188883462419 miRNAWalker2_validate -0.414139414072637 1.17943038016748e-20 NA NA NA hsa-miR-200a-3p CDON 2.02394729844446 2.21240501925011e-08 -0.742711204088021 0.0145188883462419 miRNATAP -0.49633422878287 3.5760042891601e-28 NA NA NA hsa-miR-200b-3p CDON 2.06025765178663 3.07718049337497e-10 -0.742711204088021 0.0145188883462419 mirMAP -0.529273920401939 2.64281362549273e-26 NA NA NA hsa-miR-335-3p CDON 2.29463721765513 4.1956113745077e-18 -0.742711204088021 0.0145188883462419 mirMAP -0.347403320854774 7.56268111848781e-08 NA NA NA hsa-miR-935 CDON 2.321600496365 1.00042201726114e-07 -0.742711204088021 0.0145188883462419 PITA;miRNATAP -0.31934599560254 2.72802092474262e-14 NA NA NA hsa-miR-141-5p CDR1 2.13747696823946 1.73124674554872e-11 -0.511692226152752 0.0971965144828139 MirTarget -0.341897203033753 6.61171113583327e-10 NA NA NA hsa-miR-146b-5p CDS2 2.23105707690238 3.83997814011313e-23 -0.264082281986768 0.0124768267475766 mirMAP -0.170350757032421 2.00491020275123e-11 NA NA NA hsa-miR-200a-3p CDS2 2.02394729844446 2.21240501925011e-08 -0.264082281986768 0.0124768267475766 mirMAP -0.160105101003515 6.35736447968206e-24 NA NA NA hsa-miR-200a-5p CDS2 2.19152245759943 3.17968183522514e-11 -0.264082281986768 0.0124768267475766 mirMAP -0.176846866680232 5.47407578963019e-25 NA NA NA hsa-miR-335-3p CDS2 2.29463721765513 4.1956113745077e-18 -0.264082281986768 0.0124768267475766 mirMAP -0.103361292927452 4.43113698913202e-06 NA NA NA hsa-miR-200b-3p CEBPD 2.06025765178663 3.07718049337497e-10 -0.985425400909972 5.1357147416495e-09 TargetScan -0.224360051416899 5.61546314394064e-14 NA NA NA hsa-miR-200b-3p CECR2 2.06025765178663 3.07718049337497e-10 -0.991511187827841 0.00378647640083668 TargetScan -0.378890240582351 3.0995711555874e-10 NA NA NA hsa-miR-146b-5p CELF2 2.23105707690238 3.83997814011313e-23 -1.10167045974223 7.93604111646927e-06 miRanda;mirMAP;miRNATAP -0.21569325815139 0.000529784252732619 NA NA NA hsa-miR-183-5p CELF2 2.08412478942637 1.08931431254487e-10 -1.10167045974223 7.93604111646927e-06 miRNATAP -0.500167279850722 4.90676290879659e-36 NA NA NA hsa-miR-196a-5p CELF2 5.05945965885472 4.48343841468539e-25 -1.10167045974223 7.93604111646927e-06 miRNATAP -0.207481304755687 5.30531426312597e-14 NA NA NA hsa-miR-196b-5p CELF2 4.51951031652328 7.04026169031626e-18 -1.10167045974223 7.93604111646927e-06 miRNATAP -0.217900381437696 1.96041212119785e-17 NA NA NA hsa-miR-200a-3p CELF2 2.02394729844446 2.21240501925011e-08 -1.10167045974223 7.93604111646927e-06 mirMAP -0.40164362017318 3.85411641104165e-27 NA NA NA hsa-miR-200b-3p CELF2 2.06025765178663 3.07718049337497e-10 -1.10167045974223 7.93604111646927e-06 TargetScan;mirMAP -0.431502230250276 8.39291923663402e-26 NA NA NA hsa-miR-335-3p CELF2 2.29463721765513 4.1956113745077e-18 -1.10167045974223 7.93604111646927e-06 mirMAP -0.430550833401822 3.50689265844104e-17 NA NA NA hsa-miR-935 CELF2 2.321600496365 1.00042201726114e-07 -1.10167045974223 7.93604111646927e-06 mirMAP -0.25389892929697 2.25167481074013e-13 NA NA NA hsa-miR-146b-5p CELF3 2.23105707690238 3.83997814011313e-23 -2.13596384929609 3.59673309441551e-07 miRanda -0.520762360617009 7.69622986551614e-07 NA NA NA hsa-miR-146b-3p CELF4 2.08650140817622 5.3293570720033e-22 -1.13519460130209 0.00343622354875301 MirTarget;miRNATAP -0.44056735912931 1.22214978753329e-05 NA NA NA hsa-miR-335-3p CELF4 2.29463721765513 4.1956113745077e-18 -1.13519460130209 0.00343622354875301 MirTarget;mirMAP -0.332452670342849 7.19497678074576e-05 NA NA NA hsa-miR-146b-5p CELF5 2.23105707690238 3.83997814011313e-23 -0.34464774072805 0.294611598945181 miRanda -0.226890926238074 0.00560723367631916 NA NA NA hsa-miR-194-5p CEP170 2.24386881692218 9.35116329002209e-11 0.943132881239428 1.98478653856401e-10 miRNATAP -0.105336909812093 4.41084764825746e-05 NA NA NA hsa-miR-200b-3p CEP68 2.06025765178663 3.07718049337497e-10 -0.357161821208274 0.00245788466122221 MirTarget -0.169515412180031 2.91083813231782e-17 NA NA NA hsa-miR-21-5p CEP68 2.21515015440792 6.0468197386674e-49 -0.357161821208274 0.00245788466122221 miRNATAP -0.257532466223153 3.19361210049469e-11 NA NA NA hsa-miR-335-3p CEP68 2.29463721765513 4.1956113745077e-18 -0.357161821208274 0.00245788466122221 mirMAP -0.146969944826577 3.60008713570633e-09 NA NA NA hsa-miR-18a-5p CEP85L 2.04701000113742 1.30593450319289e-12 -0.892076780989505 7.35720788146592e-07 miRNATAP -0.228311037500739 2.50163749670346e-10 NA NA NA hsa-miR-200a-5p CEP85L 2.19152245759943 3.17968183522514e-11 -0.892076780989505 7.35720788146592e-07 mirMAP -0.199644917282291 2.99339327884965e-10 NA NA NA hsa-miR-200b-3p CEP85L 2.06025765178663 3.07718049337497e-10 -0.892076780989505 7.35720788146592e-07 TargetScan -0.191512590990988 2.82593021177595e-09 NA NA NA hsa-miR-335-3p CEP85L 2.29463721765513 4.1956113745077e-18 -0.892076780989505 7.35720788146592e-07 mirMAP -0.312861887041093 7.03893913760355e-17 NA NA NA hsa-miR-146b-5p CERK 2.23105707690238 3.83997814011313e-23 -0.481351637572645 0.00116988089320183 miRanda -0.213280123451932 3.98319047246575e-09 NA NA NA hsa-miR-146b-3p CERS1 2.08650140817622 5.3293570720033e-22 -0.564917980826823 0.108810459683403 mirMAP -0.295338162368247 0.00127758987063742 NA NA NA hsa-miR-146b-5p CFL2 2.23105707690238 3.83997814011313e-23 -1.29748949709607 2.10137209702745e-06 miRanda -0.493085414650839 1.21345175545543e-13 NA NA NA hsa-miR-192-5p CFL2 2.0867723747501 3.57854249239079e-08 -1.29748949709607 2.10137209702745e-06 miRNAWalker2_validate -0.480403942492533 2.21554593265399e-36 NA NA NA hsa-miR-200b-3p CFL2 2.06025765178663 3.07718049337497e-10 -1.29748949709607 2.10137209702745e-06 MirTarget;TargetScan -0.611661644743514 1.78443301504938e-48 NA NA NA hsa-miR-335-3p CFL2 2.29463721765513 4.1956113745077e-18 -1.29748949709607 2.10137209702745e-06 MirTarget -0.519319691871358 1.93535792825405e-20 NA NA NA hsa-miR-935 CFL2 2.321600496365 1.00042201726114e-07 -1.29748949709607 2.10137209702745e-06 MirTarget -0.315835814262444 8.78680261354809e-17 NA NA NA hsa-miR-192-5p CGNL1 2.0867723747501 3.57854249239079e-08 -1.61265143988687 5.1888718612151e-07 miRNAWalker2_validate -0.435362816435892 1.30646694372153e-19 NA NA NA hsa-miR-141-5p CHD5 2.13747696823946 1.73124674554872e-11 -0.922474137133441 0.0152054367268636 MirTarget -0.557492782635139 4.69985800979568e-17 NA NA NA hsa-miR-194-5p CHD5 2.24386881692218 9.35116329002209e-11 -0.922474137133441 0.0152054367268636 mirMAP -0.402758313501684 1.34988613102394e-10 NA NA NA hsa-miR-335-3p CHD9 2.29463721765513 4.1956113745077e-18 -0.255057088271817 0.0209229203314752 MirTarget -0.116022292383606 7.47642491664452e-07 NA NA NA hsa-miR-146b-3p CHGA 2.08650140817622 5.3293570720033e-22 -5.37552476371314 1.15675444857804e-10 miRNATAP -1.000665212738 7.32660351746915e-06 NA NA NA hsa-miR-146b-5p CHIC1 2.23105707690238 3.83997814011313e-23 -0.869069841115673 0.000820067078736351 miRanda -0.318806689508371 6.99918551649391e-07 NA NA NA hsa-miR-200a-5p CHL1 2.19152245759943 3.17968183522514e-11 -1.9457439470478 7.89476279650747e-09 MirTarget;miRNATAP -0.45264165294754 1.41715103229285e-14 20957176 Overall our findings call into question the general role of miR-200 in suppressing invasion and metastasis and highlight novel distinguishing characteristics of individual miR-200 family members metastasis melanoma hsa-miR-335-3p CHL1 2.29463721765513 4.1956113745077e-18 -1.9457439470478 7.89476279650747e-09 MirTarget;mirMAP -0.468898248516537 1.11147496358968e-10 NA NA NA hsa-miR-200a-3p CHRDL1 2.02394729844446 2.21240501925011e-08 -2.81435068736559 3.17200324047588e-06 MirTarget -0.945622550590467 1.3095144569627e-24 NA NA NA hsa-miR-200b-3p CHRDL1 2.06025765178663 3.07718049337497e-10 -2.81435068736559 3.17200324047588e-06 MirTarget;TargetScan -1.01209922554632 3.13218780857773e-23 NA NA NA hsa-miR-335-3p CHRM2 2.29463721765513 4.1956113745077e-18 -2.8543543155898 6.2964660060643e-05 mirMAP -1.21099998222613 2.64659940272912e-16 NA NA NA hsa-miR-335-3p CHRM3 2.29463721765513 4.1956113745077e-18 -1.12798759512841 0.00769712541976908 mirMAP -0.411151328197717 5.99466392012035e-06 NA NA NA hsa-miR-146b-5p CHRNB2 2.23105707690238 3.83997814011313e-23 -0.900817069731551 0.0146339363110527 miRanda -0.406435735453914 8.51070344539257e-06 NA NA NA hsa-miR-194-5p CHRNB2 2.24386881692218 9.35116329002209e-11 -0.900817069731551 0.0146339363110527 mirMAP -0.18173721634057 0.00380952870578138 NA NA NA hsa-miR-200b-3p CHRNB2 2.06025765178663 3.07718049337497e-10 -0.900817069731551 0.0146339363110527 mirMAP -0.226135201552128 0.000666141667283856 NA NA NA hsa-miR-92a-1-5p CHRNB2 2.04820501765632 9.32117486799495e-13 -0.900817069731551 0.0146339363110527 MirTarget -0.168530531700564 0.0287908099630411 NA NA NA hsa-miR-200b-3p CHST11 2.06025765178663 3.07718049337497e-10 0.213090823871103 0.262681407370353 mirMAP -0.14080909945762 3.23098113207051e-05 NA NA NA hsa-miR-146b-5p CHST15 2.23105707690238 3.83997814011313e-23 -0.777252926252871 0.000654603097182122 miRanda -0.273947474611243 1.23580560407456e-06 NA NA NA hsa-miR-141-5p CHST3 2.13747696823946 1.73124674554872e-11 -0.361174355459452 0.115510344976398 mirMAP -0.318760492444768 2.28205329228047e-15 NA NA NA hsa-miR-935 CHST3 2.321600496365 1.00042201726114e-07 -0.361174355459452 0.115510344976398 mirMAP -0.1387054925325 2.2968851157878e-05 NA NA NA hsa-miR-146b-3p CHST8 2.08650140817622 5.3293570720033e-22 -1.91923125251827 9.09193570113142e-06 miRNATAP -0.295056714729144 0.010178021758937 NA NA NA hsa-miR-200b-3p CHST9 2.06025765178663 3.07718049337497e-10 -3.19932529158582 1.98123629158033e-07 TargetScan -0.578561259418833 2.05978900486222e-07 NA NA NA hsa-miR-141-5p CITED2 2.13747696823946 1.73124674554872e-11 -1.54489997373465 2.4800656042848e-22 miRNATAP -0.277111520073122 7.90524751185917e-21 NA NA NA hsa-miR-200b-3p CITED2 2.06025765178663 3.07718049337497e-10 -1.54489997373465 2.4800656042848e-22 TargetScan -0.292403787339343 7.6894781536567e-25 NA NA NA hsa-miR-196b-5p CKB 4.51951031652328 7.04026169031626e-18 -2.84100469375822 1.80384318532105e-15 miRNAWalker2_validate -0.228223759110231 1.28387972057116e-08 NA NA NA hsa-miR-935 CKB 2.321600496365 1.00042201726114e-07 -2.84100469375822 1.80384318532105e-15 miRNAWalker2_validate -0.407137028249589 4.02746473570552e-15 NA NA NA hsa-miR-194-5p CLASP1 2.24386881692218 9.35116329002209e-11 0.0864210099182321 0.350450750205728 miRNATAP -0.136772309802792 2.57188748224161e-21 NA NA NA hsa-miR-200b-3p CLASP1 2.06025765178663 3.07718049337497e-10 0.0864210099182321 0.350450750205728 MirTarget;TargetScan -0.135482032934453 2.30143104436211e-18 NA NA NA hsa-miR-141-5p CLCN6 2.13747696823946 1.73124674554872e-11 -0.031181211568156 0.779258627761344 mirMAP -0.149573447571544 1.38962441695911e-14 NA NA NA hsa-miR-146b-5p CLCN6 2.23105707690238 3.83997814011313e-23 -0.031181211568156 0.779258627761344 miRanda -0.103819199603026 0.0001485506008683 NA NA NA hsa-miR-183-5p CLCN6 2.08412478942637 1.08931431254487e-10 -0.031181211568156 0.779258627761344 mirMAP -0.152017666394661 1.79387402165349e-15 NA NA NA hsa-miR-200a-3p CLCN6 2.02394729844446 2.21240501925011e-08 -0.031181211568156 0.779258627761344 MirTarget -0.112662212252549 1.40067212007518e-10 NA NA NA hsa-miR-146b-5p CLDN10 2.23105707690238 3.83997814011313e-23 -1.93632750715696 1.36975032920686e-05 miRanda -0.682487066321396 4.70335161601901e-10 NA NA NA hsa-miR-146b-5p CLDN11 2.23105707690238 3.83997814011313e-23 -0.660975157927771 0.0595753498197424 miRanda -0.305466030125618 0.000461632745958957 NA NA NA hsa-miR-335-3p CLDND1 2.29463721765513 4.1956113745077e-18 -0.47415090918459 1.13418001089226e-06 MirTarget -0.117117285333583 2.01373745076995e-08 NA NA NA hsa-miR-935 CLEC14A 2.321600496365 1.00042201726114e-07 -0.172773724593413 0.294210539686277 MirTarget -0.131311929286386 1.39505269625173e-08 NA NA NA hsa-miR-21-5p CLIC2 2.21515015440792 6.0468197386674e-49 -0.406089491669514 0.0200197464542247 MirTarget -0.195283541816883 0.000972239599689372 NA NA NA hsa-miR-335-3p CLIC2 2.29463721765513 4.1956113745077e-18 -0.406089491669514 0.0200197464542247 MirTarget -0.239973242701926 5.21946180973716e-11 NA NA NA hsa-miR-200a-3p CLIC4 2.02394729844446 2.21240501925011e-08 -0.38961849989088 0.0412415922050508 MirTarget -0.350546487696696 4.02513696395213e-38 NA NA NA hsa-miR-200b-3p CLIC4 2.06025765178663 3.07718049337497e-10 -0.38961849989088 0.0412415922050508 MirTarget;TargetScan -0.372500384903988 5.2494412504583e-35 NA NA NA hsa-miR-200b-3p CLIP1 2.06025765178663 3.07718049337497e-10 -0.215282583297315 0.0868385355728641 TargetScan -0.196402081196344 7.21594843596929e-21 NA NA NA hsa-miR-18a-5p CLIP3 2.04701000113742 1.30593450319289e-12 -1.11675812153931 4.17995915974296e-05 miRNATAP -0.598245166843951 6.75995626703808e-34 NA NA NA hsa-miR-192-5p CLIP4 2.0867723747501 3.57854249239079e-08 -1.15401000711272 6.33323986127773e-06 miRNAWalker2_validate -0.422031813886014 2.91864723770517e-31 NA NA NA hsa-miR-194-5p CLIP4 2.24386881692218 9.35116329002209e-11 -1.15401000711272 6.33323986127773e-06 MirTarget -0.443487705282017 4.32198276584833e-29 NA NA NA hsa-miR-21-5p CLIP4 2.21515015440792 6.0468197386674e-49 -1.15401000711272 6.33323986127773e-06 miRNAWalker2_validate -0.520128166573803 1.40974934662611e-09 NA NA NA hsa-miR-192-5p CLK1 2.0867723747501 3.57854249239079e-08 -0.158615842799502 0.223068275923641 miRNAWalker2_validate -0.116810960574069 3.75978286455058e-09 NA NA NA hsa-miR-192-5p CLK4 2.0867723747501 3.57854249239079e-08 -0.0818303339579662 0.491847906638591 miRNAWalker2_validate -0.108598349447499 1.84257392433686e-09 NA NA NA hsa-miR-194-5p CLLU1 2.24386881692218 9.35116329002209e-11 -1.12792345051768 0.00877061629175733 miRNATAP -0.180945401922387 0.0138082887281924 NA NA NA hsa-miR-21-5p CLLU1 2.21515015440792 6.0468197386674e-49 -1.12792345051768 0.00877061629175733 mirMAP -0.385196447221045 0.00877530433726723 NA NA NA hsa-miR-146b-3p CLYBL 2.08650140817622 5.3293570720033e-22 -0.687374630306144 5.91746972626615e-05 mirMAP -0.155733966943333 0.000533842124192859 NA NA NA hsa-miR-18a-5p CMKLR1 2.04701000113742 1.30593450319289e-12 0.288426454932121 0.176206925083403 mirMAP -0.153954916116245 0.000334132396022303 NA NA NA hsa-miR-335-3p CMKLR1 2.29463721765513 4.1956113745077e-18 0.288426454932121 0.176206925083403 mirMAP -0.131320430276075 0.00432093213447914 NA NA NA hsa-miR-146b-5p CMYA5 2.23105707690238 3.83997814011313e-23 -0.38074113798158 0.170755359289946 miRanda -0.389753234594334 8.24583213865294e-09 NA NA NA hsa-miR-335-3p CNKSR2 2.29463721765513 4.1956113745077e-18 -1.84738040911148 0.000144389883049721 mirMAP -0.820611764752289 3.5913941448152e-16 NA NA NA hsa-miR-200b-3p CNN3 2.06025765178663 3.07718049337497e-10 -0.562615101587786 0.000315898705221665 MirTarget;TargetScan -0.23661988107496 4.65737922466567e-19 NA NA NA hsa-miR-335-3p CNR1 2.29463721765513 4.1956113745077e-18 -2.21526299777861 7.66919139588618e-06 mirMAP -0.802733038137228 9.82718343796724e-15 NA NA NA hsa-miR-335-3p CNR2 2.29463721765513 4.1956113745077e-18 0.291358447875809 0.53280113698167 mirMAP -0.347481226094886 0.000539799771739801 NA NA NA hsa-miR-146b-5p CNTFR 2.23105707690238 3.83997814011313e-23 -3.85530026542554 4.24189598216231e-12 miRNATAP -1.03764779360449 6.59601964466246e-14 NA NA NA hsa-miR-200b-3p CNTFR 2.06025765178663 3.07718049337497e-10 -3.85530026542554 4.24189598216231e-12 TargetScan -0.486805626422576 2.38127269344753e-06 NA NA NA hsa-miR-21-5p CNTFR 2.21515015440792 6.0468197386674e-49 -3.85530026542554 4.24189598216231e-12 miRNATAP -1.71637366211871 7.50798947389119e-21 NA NA NA hsa-miR-146b-5p CNTLN 2.23105707690238 3.83997814011313e-23 -0.250705692772482 0.200728994061733 miRanda -0.141901633915724 0.00359633356355535 NA NA NA hsa-miR-146b-5p CNTN1 2.23105707690238 3.83997814011313e-23 -2.59404571013433 1.8122481295543e-06 miRanda -0.963348034347395 3.57304261306962e-13 NA NA NA hsa-miR-200a-3p CNTN1 2.02394729844446 2.21240501925011e-08 -2.59404571013433 1.8122481295543e-06 MirTarget;miRNATAP -0.899856127398091 5.35939817496405e-28 NA NA NA hsa-miR-200b-3p CNTN1 2.06025765178663 3.07718049337497e-10 -2.59404571013433 1.8122481295543e-06 MirTarget -0.957062113729717 5.5253764450084e-26 NA NA NA hsa-miR-335-3p CNTN1 2.29463721765513 4.1956113745077e-18 -2.59404571013433 1.8122481295543e-06 MirTarget;mirMAP -0.829229147419023 5.42418473135461e-13 NA NA NA hsa-miR-146b-3p CNTN2 2.08650140817622 5.3293570720033e-22 -1.79921983063805 2.84045134966187e-05 miRNATAP -0.630527797634695 1.41687953838797e-08 NA NA NA hsa-miR-92a-1-5p CNTN2 2.04820501765632 9.32117486799495e-13 -1.79921983063805 2.84045134966187e-05 mirMAP -0.616156987599226 1.42733876911193e-12 NA NA NA hsa-miR-335-3p CNTN3 2.29463721765513 4.1956113745077e-18 -2.45590160465804 9.49506353676956e-09 MirTarget;mirMAP -0.671207411489615 1.8058243140492e-13 NA NA NA hsa-miR-200b-3p CNTN4 2.06025765178663 3.07718049337497e-10 -0.828286345837398 0.00133313844224883 TargetScan -0.277582421078064 1.09690256226905e-09 NA NA NA hsa-miR-335-3p CNTN4 2.29463721765513 4.1956113745077e-18 -0.828286345837398 0.00133313844224883 mirMAP -0.292873251571577 1.07884277908878e-07 NA NA NA hsa-miR-146b-5p CNTN5 2.23105707690238 3.83997814011313e-23 -0.219455842013765 0.619569509636708 miRanda -0.417554365077796 0.000133992878023009 NA NA NA hsa-miR-135b-5p CNTNAP1 2.80066701698235 2.12546333413447e-11 0.357666658494201 0.137267058981739 MirTarget -0.226814373245632 3.05266721266218e-11 NA NA NA hsa-miR-192-5p CNTNAP3 2.0867723747501 3.57854249239079e-08 -1.46487148437228 0.000329660247305951 miRNAWalker2_validate -0.526478118772523 4.24037687642614e-18 NA NA NA hsa-miR-335-3p CNTNAP3 2.29463721765513 4.1956113745077e-18 -1.46487148437228 0.000329660247305951 mirMAP -0.555903362287046 1.19103443588348e-10 NA NA NA hsa-miR-335-3p CNTNAP3B 2.29463721765513 4.1956113745077e-18 -1.04397354062633 0.0140110110114239 mirMAP -0.52014527505974 7.49513189525564e-09 NA NA NA hsa-miR-196a-5p COL14A1 5.05945965885472 4.48343841468539e-25 -0.512894835522696 0.103187481264393 miRNATAP -0.162024631499322 6.095336673943e-06 NA NA NA hsa-miR-200a-3p COL15A1 2.02394729844446 2.21240501925011e-08 0.677083427051583 0.00157583257031698 MirTarget -0.218794858767853 1.77478266992352e-10 NA NA NA hsa-miR-335-3p COL19A1 2.29463721765513 4.1956113745077e-18 -1.836697624767 0.000125507339419748 mirMAP -0.841637464808203 1.42757509162062e-17 NA NA NA hsa-miR-133a-3p COL1A1 -2.63342156915404 5.72661351480585e-12 3.01832941044284 9.17776951829232e-25 miRNAWalker2_validate -0.147252420806544 0.00287134050361538 NA NA NA hsa-miR-146b-5p COL21A1 2.23105707690238 3.83997814011313e-23 -1.27905725475759 0.000463152438377414 miRanda -0.621608997967244 2.10035516260375e-12 NA NA NA hsa-miR-146b-5p COL24A1 2.23105707690238 3.83997814011313e-23 0.0627518396785927 0.830857580241174 miRanda -0.14434865303897 0.049097990582086 NA NA NA hsa-miR-141-5p COL3A1 2.13747696823946 1.73124674554872e-11 2.02623129854542 1.91282333028184e-15 MirTarget -0.107346188901547 0.031545060932315 NA NA NA hsa-miR-135b-5p COL4A3 2.80066701698235 2.12546333413447e-11 -0.748410740217012 0.0361489474679936 MirTarget -0.370327117394683 1.8806306612024e-13 NA NA NA hsa-miR-146b-5p COL4A3 2.23105707690238 3.83997814011313e-23 -0.748410740217012 0.0361489474679936 miRanda -0.208613389161202 0.0196913213132532 NA NA NA hsa-miR-200b-3p COL4A3 2.06025765178663 3.07718049337497e-10 -0.748410740217012 0.0361489474679936 TargetScan -0.329085070334415 2.00627160069928e-07 NA NA NA hsa-miR-335-3p COL4A3 2.29463721765513 4.1956113745077e-18 -0.748410740217012 0.0361489474679936 mirMAP -0.507973829445841 9.97746150270602e-12 NA NA NA hsa-miR-146b-5p COL4A5 2.23105707690238 3.83997814011313e-23 -2.08399438260746 6.69765955151689e-08 miRanda -0.828513344826996 2.74456779515583e-19 NA NA NA hsa-miR-133a-3p COL5A3 -2.63342156915404 5.72661351480585e-12 1.31022962801182 8.50192694008228e-10 MirTarget -0.107366441447563 0.00144578850962703 NA NA NA hsa-miR-200a-3p COL8A1 2.02394729844446 2.21240501925011e-08 2.30818411810897 1.29796777642541e-11 mirMAP -0.357700959053601 2.47361708515615e-10 NA NA NA hsa-miR-146b-5p COL9A1 2.23105707690238 3.83997814011313e-23 0.937485380504135 0.0332153040304691 miRanda;miRNATAP -0.224991059147086 0.0415876040960345 NA NA NA hsa-miR-92a-1-5p COLQ 2.04820501765632 9.32117486799495e-13 -0.0281705177858252 0.88881327375582 MirTarget -0.201735997235976 8.89990030481276e-07 NA NA NA hsa-miR-146b-5p COQ9 2.23105707690238 3.83997814011313e-23 -0.672003498287729 3.59898548331829e-10 miRanda -0.115210619818849 2.37156894955816e-05 NA NA NA hsa-miR-200b-3p CORO1C 2.06025765178663 3.07718049337497e-10 -0.0594383479650764 0.605555284745698 MirTarget;TargetScan -0.204804646220886 2.4463057662874e-28 NA NA NA hsa-miR-192-5p CORO2B 2.0867723747501 3.57854249239079e-08 -1.17741661882517 2.06880794851619e-05 miRNAWalker2_validate -0.317894527561999 3.88105880453811e-14 NA NA NA hsa-miR-146b-5p CPA3 2.23105707690238 3.83997814011313e-23 -1.88581586518045 1.97575034208166e-07 miRanda -0.338189537098209 0.000238199957963439 NA NA NA hsa-miR-146b-5p CPE 2.23105707690238 3.83997814011313e-23 -1.73276081736058 1.9051287750994e-08 miRanda -0.493026562297717 1.18760743582191e-10 NA NA NA hsa-miR-146b-5p CPEB1 2.23105707690238 3.83997814011313e-23 -2.05521443455938 3.93673160768814e-09 miRanda -0.669593473347086 4.31755676615104e-15 NA NA NA hsa-miR-183-5p CPEB1 2.08412478942637 1.08931431254487e-10 -2.05521443455938 3.93673160768814e-09 miRNATAP -0.779635387695778 4.24978942642439e-45 NA NA NA hsa-miR-935 CPEB1 2.321600496365 1.00042201726114e-07 -2.05521443455938 3.93673160768814e-09 MirTarget;PITA;miRNATAP -0.387603057688046 4.05955053207614e-15 NA NA NA hsa-miR-183-5p CPEB2 2.08412478942637 1.08931431254487e-10 -0.814992840745196 1.51604703202433e-10 miRNATAP -0.157793095373313 8.47198744903213e-12 NA NA NA hsa-miR-21-5p CPEB3 2.21515015440792 6.0468197386674e-49 -0.726462801367756 6.97488351116509e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.216267807811555 8.62942699277487e-08 NA NA NA hsa-miR-335-3p CPEB3 2.29463721765513 4.1956113745077e-18 -0.726462801367756 6.97488351116509e-10 MirTarget;mirMAP -0.133840851234591 2.01083079584736e-07 NA NA NA hsa-miR-146b-3p CPEB4 2.08650140817622 5.3293570720033e-22 -0.799852896258595 5.07681536757866e-11 MirTarget;PITA;miRNATAP -0.188885292696333 3.75665037587458e-09 NA NA NA hsa-miR-335-3p CPEB4 2.29463721765513 4.1956113745077e-18 -0.799852896258595 5.07681536757866e-11 MirTarget -0.195419436550506 6.03047666475054e-14 NA NA NA hsa-miR-146b-3p CPLX2 2.08650140817622 5.3293570720033e-22 -2.77555887383287 1.80524740419883e-06 miRNATAP -0.879308307059986 5.62955308599061e-09 NA NA NA hsa-miR-183-5p CPLX2 2.08412478942637 1.08931431254487e-10 -2.77555887383287 1.80524740419883e-06 mirMAP -0.299573062378762 0.00555947496370701 NA NA NA hsa-miR-18a-5p CPLX2 2.04701000113742 1.30593450319289e-12 -2.77555887383287 1.80524740419883e-06 mirMAP -0.42664434446696 0.000356745923456543 NA NA NA hsa-miR-192-5p CPLX2 2.0867723747501 3.57854249239079e-08 -2.77555887383287 1.80524740419883e-06 mirMAP -0.302814612230807 0.00109165463822353 NA NA NA hsa-miR-200a-3p CPLX2 2.02394729844446 2.21240501925011e-08 -2.77555887383287 1.80524740419883e-06 mirMAP -0.416037689024998 1.55050012646784e-05 NA NA NA hsa-miR-200a-5p CPLX2 2.19152245759943 3.17968183522514e-11 -2.77555887383287 1.80524740419883e-06 mirMAP -0.479762885812687 4.04162840533301e-06 NA NA NA hsa-miR-935 CPNE8 2.321600496365 1.00042201726114e-07 0.0062044767507774 0.974298258402277 MirTarget;PITA -0.111831796571444 4.61269283126292e-05 NA NA NA hsa-miR-141-5p CPQ 2.13747696823946 1.73124674554872e-11 -0.794126778991682 4.23025145146621e-06 MirTarget -0.253608979603437 1.15769322465418e-16 NA NA NA hsa-miR-335-3p CPXM2 2.29463721765513 4.1956113745077e-18 -0.694533203968147 0.0535286690617411 MirTarget -0.535186571305232 8.2275935518592e-13 NA NA NA hsa-miR-183-5p CR1 2.08412478942637 1.08931431254487e-10 -0.137331836906051 0.656366490278349 miRNAWalker2_validate -0.271636457682277 8.85870544308646e-07 NA NA NA hsa-miR-146b-5p CREB3L2 2.23105707690238 3.83997814011313e-23 -0.525060002905056 1.65437910930531e-05 miRanda;mirMAP -0.119648083155724 8.85039729293425e-05 NA NA NA hsa-miR-200a-3p CREB3L2 2.02394729844446 2.21240501925011e-08 -0.525060002905056 1.65437910930531e-05 MirTarget -0.134954094240171 4.25089203067284e-12 NA NA NA hsa-miR-92a-1-5p CREB3L2 2.04820501765632 9.32117486799495e-13 -0.525060002905056 1.65437910930531e-05 MirTarget -0.134770980650094 7.77822784541326e-08 NA NA NA hsa-miR-135b-5p CREB5 2.80066701698235 2.12546333413447e-11 0.0144734137836222 0.953004773309416 MirTarget -0.105553587842045 0.00331362488173172 NA NA NA hsa-miR-200a-3p CREB5 2.02394729844446 2.21240501925011e-08 0.0144734137836222 0.953004773309416 mirMAP -0.263639813763713 1.03038591089295e-11 NA NA NA hsa-miR-200b-3p CREB5 2.06025765178663 3.07718049337497e-10 0.0144734137836222 0.953004773309416 TargetScan -0.277717096886131 7.85164672894072e-11 NA NA NA hsa-miR-18a-5p CREBL2 2.04701000113742 1.30593450319289e-12 -0.289272671162855 0.00289044434753105 miRNAWalker2_validate;MirTarget;miRNATAP -0.154826000212788 7.07074932603383e-17 NA NA NA hsa-miR-21-5p CREBL2 2.21515015440792 6.0468197386674e-49 -0.289272671162855 0.00289044434753105 miRNATAP -0.103092270759107 0.00172552603230438 NA NA NA hsa-miR-200a-3p CREBRF 2.02394729844446 2.21240501925011e-08 -0.366122742256368 0.00726639317725131 MirTarget;miRNATAP -0.181061489253937 8.63726509861667e-18 NA NA NA hsa-miR-200b-3p CREBRF 2.06025765178663 3.07718049337497e-10 -0.366122742256368 0.00726639317725131 mirMAP -0.191574323846535 1.7907977302018e-16 NA NA NA hsa-miR-21-5p CREBRF 2.21515015440792 6.0468197386674e-49 -0.366122742256368 0.00726639317725131 mirMAP;miRNATAP -0.129708255577727 0.005178530059584 NA NA NA hsa-miR-335-3p CREBRF 2.29463721765513 4.1956113745077e-18 -0.366122742256368 0.00726639317725131 MirTarget -0.223252364595722 1.67237176582536e-15 NA NA NA hsa-miR-200b-3p CRHBP 2.06025765178663 3.07718049337497e-10 -1.86592532904734 1.09075192248574e-08 MirTarget -0.496430077421681 2.1667056498941e-18 NA NA NA hsa-miR-18a-5p CRIM1 2.04701000113742 1.30593450319289e-12 0.197285946805334 0.189438220015135 MirTarget;miRNATAP -0.209918776235926 5.68439379958383e-13 NA NA NA hsa-miR-200a-5p CRIM1 2.19152245759943 3.17968183522514e-11 0.197285946805334 0.189438220015135 MirTarget -0.181606031917363 1.33002304139086e-12 NA NA NA hsa-miR-335-3p CRIM1 2.29463721765513 4.1956113745077e-18 0.197285946805334 0.189438220015135 MirTarget;mirMAP -0.10497287795728 0.00115987287148714 NA NA NA hsa-miR-335-3p CRISPLD1 2.29463721765513 4.1956113745077e-18 1.33927291826537 5.92628065458426e-06 MirTarget -0.168193632545127 0.00975518223035437 NA NA NA hsa-miR-335-3p CRISPLD2 2.29463721765513 4.1956113745077e-18 -0.410399113902154 0.0630362393453089 MirTarget -0.28183028582128 1.30103894379229e-09 NA NA NA hsa-miR-200a-3p CRMP1 2.02394729844446 2.21240501925011e-08 0.0694819941285951 0.735796589047154 MirTarget -0.233632018401295 4.75098475972989e-13 NA NA NA hsa-miR-146b-5p CROT 2.23105707690238 3.83997814011313e-23 -0.908663454132412 5.55327709432703e-06 miRanda -0.170895759933663 0.000716356956319525 NA NA NA hsa-miR-200b-3p CRTAP 2.06025765178663 3.07718049337497e-10 -0.491357908154423 0.000138058915693051 TargetScan -0.253353921703587 5.66438924935477e-35 NA NA NA hsa-miR-200a-5p CRTC1 2.19152245759943 3.17968183522514e-11 -0.115877395680035 0.28411739040102 mirMAP -0.125080361814746 1.16540067279206e-11 NA NA NA hsa-miR-200a-3p CRYBG3 2.02394729844446 2.21240501925011e-08 -0.320013638084114 0.0216908458939794 MirTarget -0.14070373022662 2.23152970691388e-10 NA NA NA hsa-miR-146b-5p CRYM 2.23105707690238 3.83997814011313e-23 -0.269399075352853 0.459419528976651 miRanda -0.23042571835483 0.0111368263966244 NA NA NA hsa-miR-141-5p CRYZL1 2.13747696823946 1.73124674554872e-11 -0.504752591629613 8.46783560452783e-07 MirTarget -0.171702143748937 3.68589040871663e-22 NA NA NA hsa-miR-200a-3p CSF3 2.02394729844446 2.21240501925011e-08 -0.848073603748178 0.13913951364429 miRNATAP -0.225629585526738 0.0167065578346016 NA NA NA hsa-miR-192-5p CSGALNACT2 2.0867723747501 3.57854249239079e-08 0.609558649145237 2.24794845816362e-07 miRNAWalker2_validate -0.112413364526062 7.88576819703072e-10 NA NA NA hsa-miR-146b-5p CSMD1 2.23105707690238 3.83997814011313e-23 -0.629962244646377 0.188813311231156 miRanda -0.422991566866797 0.000377079261467448 NA NA NA hsa-miR-183-5p CSMD1 2.08412478942637 1.08931431254487e-10 -0.629962244646377 0.188813311231156 MirTarget -0.344195662226088 7.15151235058308e-05 NA NA NA hsa-miR-192-5p CSMD1 2.0867723747501 3.57854249239079e-08 -0.629962244646377 0.188813311231156 mirMAP -0.286947548303336 0.000121438179471269 NA NA NA hsa-miR-146b-5p CSPG5 2.23105707690238 3.83997814011313e-23 -0.0955380678165559 0.728467968628998 miRanda -0.305469409290812 6.31748965251515e-06 NA NA NA hsa-miR-146b-5p CSRNP3 2.23105707690238 3.83997814011313e-23 -0.890893120904682 0.000731559220338997 mirMAP -0.471935877051041 1.00925243253088e-13 NA NA NA hsa-miR-18a-5p CSRNP3 2.04701000113742 1.30593450319289e-12 -0.890893120904682 0.000731559220338997 miRNAWalker2_validate;miRNATAP -0.395610954750672 1.27569727021297e-14 NA NA NA hsa-miR-200a-5p CSRNP3 2.19152245759943 3.17968183522514e-11 -0.890893120904682 0.000731559220338997 miRNATAP -0.340171004765059 5.06889973655943e-14 NA NA NA hsa-miR-200b-3p CSRNP3 2.06025765178663 3.07718049337497e-10 -0.890893120904682 0.000731559220338997 MirTarget;TargetScan -0.334074441789312 3.44252384732335e-13 NA NA NA hsa-miR-21-5p CSRNP3 2.21515015440792 6.0468197386674e-49 -0.890893120904682 0.000731559220338997 miRNATAP -0.481007889258498 5.48886240478367e-08 NA NA NA hsa-miR-335-3p CSRNP3 2.29463721765513 4.1956113745077e-18 -0.890893120904682 0.000731559220338997 mirMAP -0.351218163634135 3.0780393547796e-10 NA NA NA hsa-miR-146b-5p CTCFL 2.23105707690238 3.83997814011313e-23 0.66867474422682 0.0816871330326663 miRanda -0.192986037523795 0.0448371638410587 NA NA NA hsa-miR-18a-5p CTGF 2.04701000113742 1.30593450319289e-12 0.320520687991875 0.116821048397881 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.229318859680867 1.38859698228017e-08 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling poor survival glioblastoma hsa-miR-146b-3p CTIF 2.08650140817622 5.3293570720033e-22 -0.388784191562706 0.00549035394672757 MirTarget -0.138258069417062 0.000143715061892324 NA NA NA hsa-miR-146b-5p CTIF 2.23105707690238 3.83997814011313e-23 -0.388784191562706 0.00549035394672757 mirMAP -0.171883924040794 5.95151180399721e-07 NA NA NA hsa-miR-183-5p CTIF 2.08412478942637 1.08931431254487e-10 -0.388784191562706 0.00549035394672757 mirMAP -0.182763282640512 7.59848624649804e-14 NA NA NA hsa-miR-18a-5p CTIF 2.04701000113742 1.30593450319289e-12 -0.388784191562706 0.00549035394672757 mirMAP -0.228850175585024 1.13828443201054e-17 NA NA NA hsa-miR-92a-1-5p CTIF 2.04820501765632 9.32117486799495e-13 -0.388784191562706 0.00549035394672757 mirMAP -0.164503785578379 7.18731465303746e-09 NA NA NA hsa-miR-183-5p CTNNA2 2.08412478942637 1.08931431254487e-10 -2.54670372556663 1.71567743494227e-06 MirTarget;miRNATAP -0.560691356358388 6.31724410998061e-09 NA NA NA hsa-miR-146b-5p CTNNA3 2.23105707690238 3.83997814011313e-23 -2.04621545195446 0.000192816454319625 miRanda -1.00898420619112 2.13817180469033e-14 NA NA NA hsa-miR-200a-3p CTNND2 2.02394729844446 2.21240501925011e-08 -1.4845827521637 0.00260429491755341 MirTarget -0.317371538175869 8.65478983598453e-05 NA NA NA hsa-miR-200b-3p CTNND2 2.06025765178663 3.07718049337497e-10 -1.4845827521637 0.00260429491755341 MirTarget;TargetScan -0.352972532134604 6.92958623666048e-05 NA NA NA hsa-miR-135b-5p CTTNBP2 2.80066701698235 2.12546333413447e-11 -1.26060694891083 3.53497327699672e-05 MirTarget -0.190420631423901 2.2706044109765e-05 NA NA NA hsa-miR-200a-3p CTTNBP2 2.02394729844446 2.21240501925011e-08 -1.26060694891083 3.53497327699672e-05 miRNATAP -0.361174811522873 9.43599512696583e-14 NA NA NA hsa-miR-146b-5p CUEDC1 2.23105707690238 3.83997814011313e-23 -0.299754534033168 0.0647743165731234 mirMAP -0.266926576672294 7.48013217896748e-12 NA NA NA hsa-miR-146b-3p CUX1 2.08650140817622 5.3293570720033e-22 -0.0386238678767237 0.670496786532132 miRNATAP -0.101763441393032 1.14008816991704e-05 NA NA NA hsa-miR-200a-5p CUX1 2.19152245759943 3.17968183522514e-11 -0.0386238678767237 0.670496786532132 mirMAP -0.108405865810152 1.70687776969027e-12 NA NA NA hsa-miR-135b-5p CUX2 2.80066701698235 2.12546333413447e-11 -1.62910711309696 1.39734606091201e-05 MirTarget -0.21263074033818 0.000130425737243561 NA NA NA hsa-miR-335-3p CUX2 2.29463721765513 4.1956113745077e-18 -1.62910711309696 1.39734606091201e-05 mirMAP -0.425117822854124 1.43746626379134e-07 NA NA NA hsa-miR-183-5p CX3CL1 2.08412478942637 1.08931431254487e-10 -0.0955573081356533 0.702417136057544 MirTarget -0.199910278666646 8.67076243782018e-06 NA NA NA hsa-miR-200a-3p CXCL12 2.02394729844446 2.21240501925011e-08 -1.42136527893965 1.78537188106199e-07 miRNATAP -0.439974772482826 3.25425178431284e-26 NA NA NA hsa-miR-1-3p CXCL6 -2.73171785118192 3.4424534921136e-12 2.14176942200744 1.22889266763728e-06 MirTarget -0.285072991333226 1.73425014986598e-05 NA NA NA hsa-miR-146b-5p CXXC4 2.23105707690238 3.83997814011313e-23 -0.432816361201401 0.210546329161834 MirTarget;miRNATAP -0.392787753059881 3.86587285219181e-06 NA NA NA hsa-miR-21-5p CXXC4 2.21515015440792 6.0468197386674e-49 -0.432816361201401 0.210546329161834 mirMAP -0.403925283977115 0.000548779608354407 NA NA NA hsa-miR-135b-5p CYBRD1 2.80066701698235 2.12546333413447e-11 -1.57319886365625 1.13822187395473e-09 mirMAP -0.315447015128741 1.17997982058746e-17 NA NA NA hsa-miR-192-5p CYBRD1 2.0867723747501 3.57854249239079e-08 -1.57319886365625 1.13822187395473e-09 mirMAP -0.230109476386619 1.85773933185373e-08 NA NA NA hsa-miR-21-5p CYBRD1 2.21515015440792 6.0468197386674e-49 -1.57319886365625 1.13822187395473e-09 miRNAWalker2_validate -0.541525880464131 7.95535005726743e-10 NA NA NA hsa-miR-335-3p CYBRD1 2.29463721765513 4.1956113745077e-18 -1.57319886365625 1.13822187395473e-09 MirTarget -0.421405393794627 1.82677554141645e-14 NA NA NA hsa-miR-935 CYBRD1 2.321600496365 1.00042201726114e-07 -1.57319886365625 1.13822187395473e-09 MirTarget -0.246689792527785 3.30041210183157e-11 NA NA NA hsa-miR-335-3p CYFIP2 2.29463721765513 4.1956113745077e-18 -0.813876999660164 0.000398061897198668 MirTarget -0.273894573337256 2.32296340943513e-08 NA NA NA hsa-miR-200a-3p CYLD 2.02394729844446 2.21240501925011e-08 -0.36699779501181 0.00171322604977633 mirMAP -0.113304232112313 1.47006410947874e-09 NA NA NA hsa-miR-200b-3p CYP1B1 2.06025765178663 3.07718049337497e-10 -0.767683097481093 0.0530672981235295 TargetScan -0.625729296071077 4.50817949833391e-21 NA NA NA hsa-miR-335-3p CYP1B1 2.29463721765513 4.1956113745077e-18 -0.767683097481093 0.0530672981235295 mirMAP -0.481059129120071 9.89048557712864e-09 NA NA NA hsa-miR-335-3p CYP27C1 2.29463721765513 4.1956113745077e-18 -0.541077989613253 0.0815860693658821 mirMAP -0.291209293877786 1.18381569054112e-05 NA NA NA hsa-miR-335-3p CYSLTR1 2.29463721765513 4.1956113745077e-18 -1.34178967004551 3.11892302555588e-07 mirMAP -0.480903130399901 7.99361577959995e-19 NA NA NA hsa-miR-200b-3p CYTH3 2.06025765178663 3.07718049337497e-10 0.117630101294158 0.359244933780906 MirTarget;TargetScan -0.143720007633974 1.09326673889832e-10 NA NA NA hsa-miR-183-5p CYYR1 2.08412478942637 1.08931431254487e-10 -0.508329520041561 0.00210624177230402 MirTarget -0.28115795056967 3.80859766682808e-24 NA NA NA hsa-miR-183-5p DAAM1 2.08412478942637 1.08931431254487e-10 -0.338417179657082 0.0105035166930411 MirTarget;miRNATAP -0.166988940738253 5.26454692494801e-13 NA NA NA hsa-miR-194-5p DAAM1 2.24386881692218 9.35116329002209e-11 -0.338417179657082 0.0105035166930411 miRNATAP -0.220681237332713 1.5976155130651e-27 NA NA NA hsa-miR-21-5p DAAM1 2.21515015440792 6.0468197386674e-49 -0.338417179657082 0.0105035166930411 miRNAWalker2_validate -0.191165521420723 1.74085280692908e-05 NA NA NA hsa-miR-335-3p DAAM1 2.29463721765513 4.1956113745077e-18 -0.338417179657082 0.0105035166930411 mirMAP -0.137097433432839 1.14416790850049e-06 NA NA NA hsa-miR-141-5p DAAM2 2.13747696823946 1.73124674554872e-11 -1.34031580644644 1.14961034820812e-06 mirMAP -0.557709115014348 2.45084210899999e-34 NA NA NA hsa-miR-146b-5p DAAM2 2.23105707690238 3.83997814011313e-23 -1.34031580644644 1.14961034820812e-06 miRanda -0.584407132803659 5.05467630024302e-19 NA NA NA hsa-miR-18a-5p DAAM2 2.04701000113742 1.30593450319289e-12 -1.34031580644644 1.14961034820812e-06 miRNAWalker2_validate -0.593477403081751 8.46467621317108e-32 NA NA NA hsa-miR-146b-5p DACH2 2.23105707690238 3.83997814011313e-23 -1.63467942928075 0.000338069752315023 miRanda -0.574875655720438 3.58494995807439e-07 NA NA NA hsa-miR-200b-3p DACT1 2.06025765178663 3.07718049337497e-10 0.783084312335694 0.00072482171739131 TargetScan -0.19615420673442 2.25778789045408e-06 NA NA NA hsa-miR-335-3p DACT3 2.29463721765513 4.1956113745077e-18 -1.55951042695002 1.96758744197912e-06 mirMAP -0.611973021088402 1.10528848668757e-19 NA NA NA hsa-miR-92a-1-5p DACT3 2.04820501765632 9.32117486799495e-13 -1.55951042695002 1.96758744197912e-06 MirTarget -0.620876942163066 3.28765567643973e-22 NA NA NA hsa-miR-335-3p DAPP1 2.29463721765513 4.1956113745077e-18 -0.444712891482904 0.0992220219375419 mirMAP -0.183287539838135 0.00163483272527483 NA NA NA hsa-miR-146b-3p DBN1 2.08650140817622 5.3293570720033e-22 -0.230289496309915 0.227868943324431 MirTarget;PITA;miRNATAP -0.189396693554369 0.000125397190207121 NA NA NA hsa-miR-935 DBN1 2.321600496365 1.00042201726114e-07 -0.230289496309915 0.227868943324431 PITA;miRNATAP -0.10576489393854 0.000106742551540975 NA NA NA hsa-miR-146b-5p DCAF5 2.23105707690238 3.83997814011313e-23 -0.432022552798976 2.11919388779901e-08 MirTarget;miRanda -0.131326646183042 2.93588610883041e-12 NA NA NA hsa-miR-200b-3p DCAF5 2.06025765178663 3.07718049337497e-10 -0.432022552798976 2.11919388779901e-08 TargetScan -0.117968047733686 4.16585681627222e-19 NA NA NA hsa-miR-21-5p DCAF8 2.21515015440792 6.0468197386674e-49 -0.360410760328999 1.01481307378452e-08 miRNAWalker2_validate -0.196533339601291 5.67891964405955e-23 NA NA NA hsa-miR-192-5p DCBLD2 2.0867723747501 3.57854249239079e-08 -0.142686813220974 0.552400988273795 miRNAWalker2_validate -0.266087004125423 1.3538705034276e-13 NA NA NA hsa-miR-194-5p DCBLD2 2.24386881692218 9.35116329002209e-11 -0.142686813220974 0.552400988273795 MirTarget -0.291652726884174 6.07438074526255e-14 NA NA NA hsa-miR-200b-3p DCBLD2 2.06025765178663 3.07718049337497e-10 -0.142686813220974 0.552400988273795 MirTarget;TargetScan -0.314823423852922 1.99333147051828e-14 NA NA NA hsa-miR-335-3p DCBLD2 2.29463721765513 4.1956113745077e-18 -0.142686813220974 0.552400988273795 mirMAP -0.227374356593752 8.9695183808209e-06 NA NA NA hsa-miR-183-5p DCC 2.08412478942637 1.08931431254487e-10 -1.42868145100676 5.14784667987675e-05 MirTarget -0.183252204603491 0.00491112274537343 NA NA NA hsa-miR-146b-5p DCHS2 2.23105707690238 3.83997814011313e-23 -1.97976312278223 1.40211619872863e-05 miRanda -0.757177771550007 1.06467073134873e-11 NA NA NA hsa-miR-146b-5p DCLK1 2.23105707690238 3.83997814011313e-23 -1.32352503962546 0.000138162205768269 miRanda -0.386702602857114 7.98284050338354e-06 NA NA NA hsa-miR-146b-5p DCLK2 2.23105707690238 3.83997814011313e-23 -0.651252143052189 0.0148633843486014 miRanda -0.46882637933164 2.54940903711878e-13 NA NA NA hsa-miR-146b-5p DCN 2.23105707690238 3.83997814011313e-23 -1.28768336573181 1.77893612580028e-07 miRanda -0.323488500307951 1.63139130963641e-07 NA NA NA hsa-miR-194-5p DCUN1D4 2.24386881692218 9.35116329002209e-11 -0.256427886046376 0.0215922527238607 MirTarget -0.107214804868989 6.11313524824303e-09 NA NA NA hsa-miR-335-3p DCUN1D4 2.29463721765513 4.1956113745077e-18 -0.256427886046376 0.0215922527238607 mirMAP -0.100083035227195 2.71073278269957e-05 NA NA NA hsa-miR-135b-5p DCX 2.80066701698235 2.12546333413447e-11 -0.844677817637489 0.10668674687843 mirMAP -0.429023854083368 1.1461187882943e-08 NA NA NA hsa-miR-146b-3p DCX 2.08650140817622 5.3293570720033e-22 -0.844677817637489 0.10668674687843 PITA;miRNATAP -0.417198301376339 0.00223266962818166 NA NA NA hsa-miR-183-5p DCX 2.08412478942637 1.08931431254487e-10 -0.844677817637489 0.10668674687843 MirTarget;miRNATAP -0.620127656556368 1.72052217681191e-11 NA NA NA hsa-miR-192-5p DCX 2.0867723747501 3.57854249239079e-08 -0.844677817637489 0.10668674687843 mirMAP -0.242374009765048 0.00315054639434713 NA NA NA hsa-miR-200a-5p DCX 2.19152245759943 3.17968183522514e-11 -0.844677817637489 0.10668674687843 mirMAP -0.432205654352647 2.56487921027638e-06 NA NA NA hsa-miR-335-3p DCX 2.29463721765513 4.1956113745077e-18 -0.844677817637489 0.10668674687843 mirMAP -0.26926509483729 0.0176584449206159 NA NA NA hsa-miR-935 DCX 2.321600496365 1.00042201726114e-07 -0.844677817637489 0.10668674687843 mirMAP -0.462757007892041 2.76562232037648e-10 NA NA NA hsa-miR-146b-5p DDHD2 2.23105707690238 3.83997814011313e-23 -0.154583103342212 0.193842372532219 miRanda -0.114277047203303 9.67687323554251e-05 NA NA NA hsa-miR-21-5p DDHD2 2.21515015440792 6.0468197386674e-49 -0.154583103342212 0.193842372532219 miRNAWalker2_validate -0.116144211349697 0.00385437164328784 NA NA NA hsa-miR-146b-5p DDIT4L 2.23105707690238 3.83997814011313e-23 -0.0261842619153567 0.939891667299729 miRanda -0.210386002958198 0.0150740381007397 NA NA NA hsa-miR-200b-3p DDIT4L 2.06025765178663 3.07718049337497e-10 -0.0261842619153567 0.939891667299729 MirTarget -0.456978740330051 1.57397895289192e-14 NA NA NA hsa-miR-21-5p DDR2 2.21515015440792 6.0468197386674e-49 -0.761379109868812 0.0066880292071355 miRNAWalker2_validate -0.495161070948485 1.38635305253879e-07 NA NA NA hsa-miR-200b-3p DDX3Y 2.06025765178663 3.07718049337497e-10 -1.08011892315372 0.269270157228425 TargetScan -0.378958463767422 0.0318118681059195 NA NA NA hsa-miR-192-5p DDX6 2.0867723747501 3.57854249239079e-08 0.0909600078885502 0.364279387413942 miRNATAP -0.101476602458218 1.59501372278656e-11 NA NA NA hsa-miR-192-5p DEGS1 2.0867723747501 3.57854249239079e-08 -0.172879256073472 0.103647058225951 miRNAWalker2_validate -0.105462847337841 4.68525392348291e-11 NA NA NA hsa-miR-18a-5p DENND3 2.04701000113742 1.30593450319289e-12 -0.0793981103553509 0.555008431064633 MirTarget -0.116540459968868 1.38616724868265e-05 NA NA NA hsa-miR-200b-3p DENND5A 2.06025765178663 3.07718049337497e-10 -0.152606794957467 0.390594828957252 MirTarget;TargetScan -0.335479849422894 1.89571003610997e-32 NA NA NA hsa-miR-146b-3p DES 2.08650140817622 5.3293570720033e-22 -3.46290337435781 5.38276943411829e-07 miRNATAP -1.18480963885633 2.80801304647289e-11 NA NA NA hsa-miR-141-5p DGKB 2.13747696823946 1.73124674554872e-11 -1.48437958284152 0.00101300882057666 MirTarget;miRNATAP -0.753451962530273 2.81920604841137e-22 NA NA NA hsa-miR-335-3p DGKB 2.29463721765513 4.1956113745077e-18 -1.48437958284152 0.00101300882057666 MirTarget;mirMAP -0.623115061396273 6.08807801119016e-11 NA NA NA hsa-miR-183-5p DGKE 2.08412478942637 1.08931431254487e-10 -0.00340647233663693 0.981614022782547 miRNATAP -0.142996497238506 5.15445772871762e-08 NA NA NA hsa-miR-146b-5p DGKG 2.23105707690238 3.83997814011313e-23 -1.62731283052773 1.74564014186277e-07 miRNATAP -0.541416977741749 1.38258439098411e-12 NA NA NA hsa-miR-335-3p DGKG 2.29463721765513 4.1956113745077e-18 -1.62731283052773 1.74564014186277e-07 mirMAP -0.465037515703163 2.31144840076576e-12 NA NA NA hsa-miR-335-3p DHRS7 2.29463721765513 4.1956113745077e-18 -1.2753094407275 1.03120605780034e-17 mirMAP -0.150675472285933 8.72726581892153e-06 NA NA NA hsa-miR-1-3p DHX15 -2.73171785118192 3.4424534921136e-12 0.446468018913996 7.87043375549425e-07 MirTarget -0.130842344929284 4.44259658612557e-26 NA NA NA hsa-miR-135b-5p DIP2C 2.80066701698235 2.12546333413447e-11 -0.435698447281526 0.0171338140505864 MirTarget -0.195019958389865 2.97205547540686e-14 NA NA NA hsa-miR-18a-5p DIP2C 2.04701000113742 1.30593450319289e-12 -0.435698447281526 0.0171338140505864 MirTarget;miRNATAP -0.345265551756589 2.75494826849647e-24 NA NA NA hsa-miR-194-5p DIP2C 2.24386881692218 9.35116329002209e-11 -0.435698447281526 0.0171338140505864 miRNATAP -0.220336100722358 1.25815864260458e-13 NA NA NA hsa-miR-935 DIP2C 2.321600496365 1.00042201726114e-07 -0.435698447281526 0.0171338140505864 mirMAP -0.181691878661378 7.64149150140199e-13 NA NA NA hsa-miR-146b-5p DIRAS2 2.23105707690238 3.83997814011313e-23 -2.05223261985053 1.29402751264844e-05 miRanda -0.610227690358336 1.86646785914074e-07 NA NA NA hsa-miR-200b-3p DIRAS2 2.06025765178663 3.07718049337497e-10 -2.05223261985053 1.29402751264844e-05 TargetScan -0.173060093145271 0.0452325597936238 NA NA NA hsa-miR-141-5p DIXDC1 2.13747696823946 1.73124674554872e-11 -1.16493051519743 1.82036516809915e-06 mirMAP -0.553859393670702 4.81902572655138e-47 NA NA NA hsa-miR-146b-5p DIXDC1 2.23105707690238 3.83997814011313e-23 -1.16493051519743 1.82036516809915e-06 miRanda -0.501612915227397 7.89980762975949e-18 NA NA NA hsa-miR-200b-3p DIXDC1 2.06025765178663 3.07718049337497e-10 -1.16493051519743 1.82036516809915e-06 MirTarget;TargetScan -0.485006218246082 5.46445881627915e-35 NA NA NA hsa-miR-335-3p DIXDC1 2.29463721765513 4.1956113745077e-18 -1.16493051519743 1.82036516809915e-06 mirMAP -0.468682627298937 5.98737912885758e-21 NA NA NA hsa-miR-146b-5p DLC1 2.23105707690238 3.83997814011313e-23 -0.381837238292576 0.0503828744141603 miRanda -0.277337739651286 5.18563623438304e-09 NA NA NA hsa-miR-200a-3p DLC1 2.02394729844446 2.21240501925011e-08 -0.381837238292576 0.0503828744141603 miRNATAP -0.297989337757196 3.01606363771657e-24 NA NA NA hsa-miR-200a-5p DLC1 2.19152245759943 3.17968183522514e-11 -0.381837238292576 0.0503828744141603 miRNATAP -0.311064966634327 2.81428606046952e-22 NA NA NA hsa-miR-200b-3p DLC1 2.06025765178663 3.07718049337497e-10 -0.381837238292576 0.0503828744141603 TargetScan -0.322209760284385 1.99020324412842e-23 NA NA NA hsa-miR-335-3p DLC1 2.29463721765513 4.1956113745077e-18 -0.381837238292576 0.0503828744141603 mirMAP -0.231815167301965 1.92367646163534e-08 NA NA NA hsa-miR-135b-5p DLG2 2.80066701698235 2.12546333413447e-11 -1.81014192836189 4.31399222582451e-07 MirTarget -0.457511076547874 7.0447206162113e-20 NA NA NA hsa-miR-146b-5p DLG2 2.23105707690238 3.83997814011313e-23 -1.81014192836189 4.31399222582451e-07 miRanda -0.675773679106378 7.46309080775858e-15 NA NA NA hsa-miR-335-3p DLG2 2.29463721765513 4.1956113745077e-18 -1.81014192836189 4.31399222582451e-07 mirMAP -0.554977409797932 2.46740442000624e-13 NA NA NA hsa-miR-935 DLG2 2.321600496365 1.00042201726114e-07 -1.81014192836189 4.31399222582451e-07 MirTarget;PITA -0.405549083075035 5.14488516438092e-16 NA NA NA hsa-miR-192-5p DLG5 2.0867723747501 3.57854249239079e-08 0.258176717985961 0.0632228839548884 miRNAWalker2_validate -0.128858531237489 1.13363732934286e-09 NA NA NA hsa-miR-146b-3p DLGAP1 2.08650140817622 5.3293570720033e-22 -0.647423997568855 0.0946203290041561 miRNATAP -0.233973217292063 0.0209379481095294 NA NA NA hsa-miR-146b-5p DLGAP1 2.23105707690238 3.83997814011313e-23 -0.647423997568855 0.0946203290041561 PITA;miRanda;miRNATAP -0.240258610481043 0.0130567537847702 NA NA NA hsa-miR-21-5p DLGAP1 2.21515015440792 6.0468197386674e-49 -0.647423997568855 0.0946203290041561 miRNATAP -0.333725803145897 0.0113540978651758 NA NA NA hsa-miR-146b-5p DLL1 2.23105707690238 3.83997814011313e-23 -0.367321557272473 0.0311156953180708 miRanda -0.129951184833849 0.00220094366936586 NA NA NA hsa-miR-146b-5p DLX1 2.23105707690238 3.83997814011313e-23 -0.0867696373711926 0.830573716972478 miRanda -0.290310053599956 0.00400452720125215 NA NA NA hsa-miR-200a-3p DLX5 2.02394729844446 2.21240501925011e-08 0.467035033598791 0.229765245212111 miRNAWalker2_validate;miRTarBase -0.268013516383989 2.19054842959425e-05 NA NA NA hsa-miR-146b-5p DMD 2.23105707690238 3.83997814011313e-23 -1.50584693629303 4.05157194167937e-06 miRanda -0.647609520064127 1.45495980074468e-16 NA NA NA hsa-miR-194-5p DMD 2.24386881692218 9.35116329002209e-11 -1.50584693629303 4.05157194167937e-06 MirTarget;miRNATAP -0.416822087786363 8.89959503505852e-15 NA NA NA hsa-miR-200b-3p DMD 2.06025765178663 3.07718049337497e-10 -1.50584693629303 4.05157194167937e-06 TargetScan -0.601552511353115 5.33364821089218e-29 NA NA NA hsa-miR-21-5p DMD 2.21515015440792 6.0468197386674e-49 -1.50584693629303 4.05157194167937e-06 miRNAWalker2_validate -0.805216804768577 9.17890581926293e-14 NA NA NA hsa-miR-935 DMD 2.321600496365 1.00042201726114e-07 -1.50584693629303 4.05157194167937e-06 MirTarget;PITA;miRNATAP -0.440272440637021 1.6861716466436e-23 NA NA NA hsa-miR-200a-3p DMWD 2.02394729844446 2.21240501925011e-08 -0.108612632280899 0.288132402114401 MirTarget;miRNATAP -0.137910091451994 9.57309009812559e-19 NA NA NA hsa-miR-335-3p DMXL1 2.29463721765513 4.1956113745077e-18 -0.426316165989206 0.000564374242286973 mirMAP -0.115824056491499 1.31299987656751e-05 NA NA NA hsa-miR-192-5p DNAJB4 2.0867723747501 3.57854249239079e-08 -0.699790825105696 7.61829706903065e-06 miRNAWalker2_validate -0.258570415571564 1.51422887158205e-31 NA NA NA hsa-miR-192-5p DNAJB5 2.0867723747501 3.57854249239079e-08 -1.63239432731099 4.88248701689133e-08 miRNAWalker2_validate -0.536416141443651 1.03386568429183e-37 NA NA NA hsa-miR-200b-3p DNAJB5 2.06025765178663 3.07718049337497e-10 -1.63239432731099 4.88248701689133e-08 TargetScan -0.684464035071018 7.69388306734523e-51 NA NA NA hsa-miR-200b-3p DNAJC18 2.06025765178663 3.07718049337497e-10 -0.991567847547574 6.93843475640889e-08 TargetScan -0.392810907369169 6.6029430388378e-42 NA NA NA hsa-miR-335-3p DNAJC18 2.29463721765513 4.1956113745077e-18 -0.991567847547574 6.93843475640889e-08 mirMAP -0.329650312427943 7.00097410419558e-18 NA NA NA hsa-miR-200a-5p DNAJC27 2.19152245759943 3.17968183522514e-11 -0.325267145105422 0.00397687264468454 MirTarget -0.152709760982631 1.16009827641682e-15 NA NA NA hsa-miR-335-3p DNAJC6 2.29463721765513 4.1956113745077e-18 -0.551240027792456 0.0796502506719847 mirMAP -0.203861412818649 0.00269798448895008 NA NA NA hsa-miR-192-5p DNAL1 2.0867723747501 3.57854249239079e-08 0.0480634598292551 0.634935736519382 miRNAWalker2_validate -0.118779383699473 1.95674694853594e-15 NA NA NA hsa-miR-146b-5p DNALI1 2.23105707690238 3.83997814011313e-23 -0.565521494054433 0.0431395981258433 miRanda -0.246338388096748 0.000394404477675662 NA NA NA hsa-miR-183-5p DNALI1 2.08412478942637 1.08931431254487e-10 -0.565521494054433 0.0431395981258433 MirTarget -0.161131992511152 0.00155283291876344 NA NA NA hsa-miR-196a-5p DNM3 5.05945965885472 4.48343841468539e-25 -1.05105517905944 2.72866280933461e-06 MirTarget -0.118861075024531 4.61010953932244e-06 NA NA NA hsa-miR-196b-5p DNM3 4.51951031652328 7.04026169031626e-18 -1.05105517905944 2.72866280933461e-06 MirTarget -0.119877448403557 8.98432905235671e-07 NA NA NA hsa-miR-200b-3p DNM3 2.06025765178663 3.07718049337497e-10 -1.05105517905944 2.72866280933461e-06 mirMAP -0.182234043682248 7.18055914538978e-06 NA NA NA hsa-miR-335-3p DNM3 2.29463721765513 4.1956113745077e-18 -1.05105517905944 2.72866280933461e-06 mirMAP -0.2928155215729 1.02559839787111e-09 NA NA NA hsa-miR-935 DNM3 2.321600496365 1.00042201726114e-07 -1.05105517905944 2.72866280933461e-06 PITA -0.166890448850303 2.41338177749012e-07 NA NA NA hsa-miR-200b-3p DNMT3A 2.06025765178663 3.07718049337497e-10 0.301869013127361 0.0262018308733428 MirTarget;TargetScan -0.106005375987799 1.15742159683197e-05 NA NA NA hsa-miR-196a-5p DOCK3 5.05945965885472 4.48343841468539e-25 -0.94476914559944 0.00697193207799253 miRNATAP -0.21489178898548 6.20961240675115e-08 NA NA NA hsa-miR-196b-5p DOCK3 4.51951031652328 7.04026169031626e-18 -0.94476914559944 0.00697193207799253 miRNATAP -0.197366085019647 1.42867151862311e-07 NA NA NA hsa-miR-200a-3p DOCK4 2.02394729844446 2.21240501925011e-08 0.502120813551762 0.00108492735386023 MirTarget -0.130340326127494 1.62657685278471e-07 NA NA NA hsa-miR-200b-3p DOCK4 2.06025765178663 3.07718049337497e-10 0.502120813551762 0.00108492735386023 MirTarget;TargetScan -0.122601879526226 8.34236139890405e-06 NA NA NA hsa-miR-192-5p DOK6 2.0867723747501 3.57854249239079e-08 -0.225684072173497 0.316613807414311 mirMAP -0.241161767350778 1.09956254326686e-12 NA NA NA hsa-miR-196a-5p DOK6 5.05945965885472 4.48343841468539e-25 -0.225684072173497 0.316613807414311 miRNATAP -0.118022817934071 3.92301630466564e-06 NA NA NA hsa-miR-196b-5p DOK6 4.51951031652328 7.04026169031626e-18 -0.225684072173497 0.316613807414311 miRNATAP -0.156154773963585 3.85398069901313e-11 NA NA NA hsa-miR-21-5p DOK6 2.21515015440792 6.0468197386674e-49 -0.225684072173497 0.316613807414311 mirMAP -0.285509547252653 0.000170163521621139 NA NA NA hsa-miR-335-3p DOK6 2.29463721765513 4.1956113745077e-18 -0.225684072173497 0.316613807414311 MirTarget;mirMAP -0.257743576268462 6.3074852587752e-08 NA NA NA hsa-miR-146b-5p DPCR1 2.23105707690238 3.83997814011313e-23 -3.7669873692923 8.82257560737345e-07 miRanda -0.549592329310435 0.00484641102083074 NA NA NA hsa-miR-18a-5p DPF3 2.04701000113742 1.30593450319289e-12 -0.909440754344674 1.59950961658736e-05 mirMAP -0.122915381141838 0.00452217082705739 NA NA NA hsa-miR-18a-5p DPP10 2.04701000113742 1.30593450319289e-12 -3.08431951945485 4.06938964432353e-08 miRNATAP -0.748220228515288 3.52341677670431e-11 NA NA NA hsa-miR-335-3p DPP10 2.29463721765513 4.1956113745077e-18 -3.08431951945485 4.06938964432353e-08 mirMAP -0.853205557133596 1.08206111245498e-12 NA NA NA hsa-miR-146b-5p DPY19L2 2.23105707690238 3.83997814011313e-23 -0.673450747858854 0.0407747171981825 MirTarget;miRanda -0.403941076705673 5.96197719462445e-07 NA NA NA hsa-miR-335-3p DPYD 2.29463721765513 4.1956113745077e-18 -0.73554340792699 0.000757492004201142 MirTarget;mirMAP -0.218329360246513 3.32472693072398e-06 NA NA NA hsa-miR-141-5p DPYSL2 2.13747696823946 1.73124674554872e-11 0.595486876972282 0.000195330903529268 miRNATAP -0.192960658112052 1.9212473415751e-11 NA NA NA hsa-miR-141-5p DPYSL3 2.13747696823946 1.73124674554872e-11 -0.036251002618835 0.901571267759705 MirTarget -0.560051946343332 2.11604382120775e-31 NA NA NA hsa-miR-335-3p DPYSL3 2.29463721765513 4.1956113745077e-18 -0.036251002618835 0.901571267759705 mirMAP -0.354741440802996 9.08905597949208e-09 NA NA NA hsa-miR-192-5p DPYSL5 2.0867723747501 3.57854249239079e-08 0.206890952397277 0.717768750141068 mirMAP -0.487351850116109 2.73151282451788e-08 NA NA NA hsa-miR-92a-1-5p DPYSL5 2.04820501765632 9.32117486799495e-13 0.206890952397277 0.717768750141068 MirTarget -0.466015735857017 7.55635120882656e-05 NA NA NA hsa-miR-18a-5p DRP2 2.04701000113742 1.30593450319289e-12 0.220184444256278 0.492566369927964 mirMAP -0.286586665058364 7.82805047705933e-06 NA NA NA hsa-miR-200b-3p DRP2 2.06025765178663 3.07718049337497e-10 0.220184444256278 0.492566369927964 mirMAP -0.447831478473495 2.28352194846373e-16 NA NA NA hsa-miR-335-3p DRP2 2.29463721765513 4.1956113745077e-18 0.220184444256278 0.492566369927964 mirMAP -0.143098598886217 0.039401996251005 NA NA NA hsa-miR-92a-1-5p DRP2 2.04820501765632 9.32117486799495e-13 0.220184444256278 0.492566369927964 MirTarget -0.217157439609294 0.00105455692515757 NA NA NA hsa-miR-335-3p DSCAML1 2.29463721765513 4.1956113745077e-18 -2.21634581389244 6.361189387306e-08 MirTarget -0.463093654916473 2.11176395053667e-07 NA NA NA hsa-miR-141-5p DSE 2.13747696823946 1.73124674554872e-11 -0.231318207076859 0.0534669114878373 MirTarget -0.141086780961567 3.6021867983422e-11 NA NA NA hsa-miR-21-5p DSE 2.21515015440792 6.0468197386674e-49 -0.231318207076859 0.0534669114878373 miRNAWalker2_validate -0.108614468692268 0.00745491647752206 NA NA NA hsa-miR-935 DSEL 2.321600496365 1.00042201726114e-07 -0.67285265642764 0.0053381936162325 MirTarget;miRNATAP -0.233585127499444 4.15225306277114e-12 NA NA NA hsa-miR-146b-5p DST 2.23105707690238 3.83997814011313e-23 -0.712661407535561 0.000959062290630929 miRanda -0.357103724583807 8.34280840938207e-12 NA NA NA hsa-miR-183-5p DST 2.08412478942637 1.08931431254487e-10 -0.712661407535561 0.000959062290630929 mirMAP -0.311974999733584 7.28800383357766e-17 NA NA NA hsa-miR-18a-5p DST 2.04701000113742 1.30593450319289e-12 -0.712661407535561 0.000959062290630929 mirMAP -0.327995032753775 4.77747348394454e-15 NA NA NA hsa-miR-192-5p DST 2.0867723747501 3.57854249239079e-08 -0.712661407535561 0.000959062290630929 miRNAWalker2_validate;mirMAP -0.267602801247337 9.52253045322956e-17 NA NA NA hsa-miR-200a-3p DST 2.02394729844446 2.21240501925011e-08 -0.712661407535561 0.000959062290630929 mirMAP -0.293980178779893 1.46352046389434e-18 NA NA NA hsa-miR-200b-3p DST 2.06025765178663 3.07718049337497e-10 -0.712661407535561 0.000959062290630929 mirMAP -0.3161286012647 9.09413741517529e-18 NA NA NA hsa-miR-21-5p DST 2.21515015440792 6.0468197386674e-49 -0.712661407535561 0.000959062290630929 mirMAP -0.344572502913902 2.2310417959655e-06 22403704 While the EDCs and estrogen similarly altered the expression of multiple microRNAs in MCF-7 cells including miR-21 differential patterns of microRNA expression were induced by DDT and BPA compared to estrogen breast cancer hsa-miR-335-3p DST 2.29463721765513 4.1956113745077e-18 -0.712661407535561 0.000959062290630929 mirMAP -0.252059412030602 4.3081279729732e-08 NA NA NA hsa-miR-192-5p DSTYK 2.0867723747501 3.57854249239079e-08 0.140649893281743 0.203401353379972 miRNAWalker2_validate -0.151260304560656 3.01849739774487e-21 NA NA NA hsa-miR-200a-3p DSTYK 2.02394729844446 2.21240501925011e-08 0.140649893281743 0.203401353379972 MirTarget -0.130796828116733 3.00011512660518e-14 NA NA NA hsa-miR-146b-5p DTNA 2.23105707690238 3.83997814011313e-23 -1.64790334674543 7.31937738648404e-06 MirTarget;PITA;miRanda;miRNATAP -0.647267889178922 4.43765049116258e-13 NA NA NA hsa-miR-183-5p DTNA 2.08412478942637 1.08931431254487e-10 -1.64790334674543 7.31937738648404e-06 MirTarget;miRNATAP -0.701017961909067 8.45394670688868e-31 NA NA NA hsa-miR-18a-5p DTNA 2.04701000113742 1.30593450319289e-12 -1.64790334674543 7.31937738648404e-06 mirMAP -0.607957705394702 1.425188609464e-17 NA NA NA hsa-miR-200b-3p DTNA 2.06025765178663 3.07718049337497e-10 -1.64790334674543 7.31937738648404e-06 MirTarget;TargetScan -0.673152027501618 1.03884336718138e-28 NA NA NA hsa-miR-335-3p DTNA 2.29463721765513 4.1956113745077e-18 -1.64790334674543 7.31937738648404e-06 mirMAP -0.6079750079976 2.3563101947189e-15 NA NA NA hsa-miR-146b-5p DTWD1 2.23105707690238 3.83997814011313e-23 -0.234822958069224 0.0348431779454821 miRanda -0.108587900899786 7.66427674002024e-05 NA NA NA hsa-miR-146b-5p DTX3 2.23105707690238 3.83997814011313e-23 -0.857724830658873 0.000283865817930961 miRanda;miRNATAP -0.352021042626239 1.19228905060442e-09 NA NA NA hsa-miR-92a-1-5p DUOX1 2.04820501765632 9.32117486799495e-13 -1.33408628981752 0.000146438871336336 MirTarget -0.187119790597351 0.0113010114592246 NA NA NA hsa-miR-200b-3p DUSP1 2.06025765178663 3.07718049337497e-10 -1.75402429649966 1.13529116708344e-13 MirTarget;TargetScan -0.341211822872468 7.80535205483735e-16 NA NA NA hsa-miR-194-5p DUSP10 2.24386881692218 9.35116329002209e-11 0.50966901484879 0.00227549186291354 miRNATAP -0.111650445053494 7.82041442734661e-05 NA NA NA hsa-miR-200a-3p DUSP3 2.02394729844446 2.21240501925011e-08 -0.535283506428631 4.81242862721625e-05 MirTarget;miRNATAP -0.215082804297825 1.01000735154061e-27 NA NA NA hsa-miR-21-5p DUSP8 2.21515015440792 6.0468197386674e-49 -0.138770521214301 0.439264281546499 miRNAWalker2_validate;MirTarget -0.183282023719592 0.00252174568625556 NA NA NA hsa-miR-146b-3p DYNC1I1 2.08650140817622 5.3293570720033e-22 -1.12027945318246 0.00107388621207106 MirTarget;PITA -0.627822894928402 3.56620943240785e-13 NA NA NA hsa-miR-183-5p DYNC1I1 2.08412478942637 1.08931431254487e-10 -1.12027945318246 0.00107388621207106 MirTarget -0.641650681777612 4.1934457444217e-30 NA NA NA hsa-miR-200a-3p DYNC1I1 2.02394729844446 2.21240501925011e-08 -1.12027945318246 0.00107388621207106 MirTarget -0.564450900102636 1.85940986539915e-28 NA NA NA hsa-miR-200b-3p DYNC1I1 2.06025765178663 3.07718049337497e-10 -1.12027945318246 0.00107388621207106 MirTarget -0.608778957359152 2.76789008517971e-27 NA NA NA hsa-miR-21-5p DYNC1LI2 2.21515015440792 6.0468197386674e-49 -0.151678434580852 0.11155732630237 miRNAWalker2_validate -0.107993496007619 0.000751077287290826 NA NA NA hsa-miR-146b-5p DYNLL2 2.23105707690238 3.83997814011313e-23 -0.298831747533299 0.0017412365554985 miRanda -0.111262060846264 2.12849141635904e-06 NA NA NA hsa-miR-200a-3p DZIP1 2.02394729844446 2.21240501925011e-08 -0.88362320879615 0.00028568683997458 miRNATAP -0.426691348863454 6.0838620039795e-33 NA NA NA hsa-miR-200a-5p DZIP1 2.19152245759943 3.17968183522514e-11 -0.88362320879615 0.00028568683997458 mirMAP -0.44980039415697 9.58334845284766e-31 NA NA NA hsa-miR-200b-3p DZIP1 2.06025765178663 3.07718049337497e-10 -0.88362320879615 0.00028568683997458 MirTarget;TargetScan -0.459367082783166 2.23483215657587e-31 NA NA NA hsa-miR-1-3p E2F5 -2.73171785118192 3.4424534921136e-12 0.556543885746152 0.000229830635611877 MirTarget -0.145985268051019 2.59816017008545e-11 NA NA NA hsa-miR-335-3p EBF1 2.29463721765513 4.1956113745077e-18 -0.384145010395955 0.0885592077910048 mirMAP -0.311311975673628 3.99709469190089e-11 NA NA NA hsa-miR-935 EBF1 2.321600496365 1.00042201726114e-07 -0.384145010395955 0.0885592077910048 MirTarget -0.205258191082759 7.03653776014432e-11 NA NA NA hsa-miR-200a-5p EBF2 2.19152245759943 3.17968183522514e-11 1.62736261668709 2.99671818165223e-06 miRNATAP -0.394747063041559 1.05420207423384e-10 NA NA NA hsa-miR-335-3p EBF3 2.29463721765513 4.1956113745077e-18 -0.0578760368084503 0.814374219241758 mirMAP -0.265573136399599 3.71335328150697e-07 NA NA NA hsa-miR-21-5p ECI2 2.21515015440792 6.0468197386674e-49 -0.874473345533636 1.26576116281351e-08 miRNAWalker2_validate -0.243625122163077 4.10547171377639e-06 NA NA NA hsa-miR-335-3p ECM2 2.29463721765513 4.1956113745077e-18 0.042243549302635 0.840723118441331 MirTarget -0.192088781124273 1.84116860156977e-05 NA NA NA hsa-miR-141-5p EDA 2.13747696823946 1.73124674554872e-11 -0.372450144691841 0.22226981888951 mirMAP -0.13593188904743 0.01591979604655 NA NA NA hsa-miR-21-5p EDIL3 2.21515015440792 6.0468197386674e-49 -0.975272918471383 5.22685481386266e-06 miRNAWalker2_validate;MirTarget -0.369963387882668 3.56890675405255e-07 NA NA NA hsa-miR-335-3p EDIL3 2.29463721765513 4.1956113745077e-18 -0.975272918471383 5.22685481386266e-06 MirTarget -0.273559326193931 2.38673992930686e-09 NA NA NA hsa-miR-935 EDIL3 2.321600496365 1.00042201726114e-07 -0.975272918471383 5.22685481386266e-06 MirTarget -0.113948451102727 0.000262746459984023 NA NA NA hsa-miR-146b-5p EDNRB 2.23105707690238 3.83997814011313e-23 -0.681650878101628 0.00138317682949008 miRanda;miRNATAP -0.169124671285245 0.00153415487425067 NA NA NA hsa-miR-192-5p EEF1A2 2.0867723747501 3.57854249239079e-08 -3.58448086492029 3.42501683188058e-10 miRNAWalker2_validate -0.380332471366233 3.50156845837547e-05 NA NA NA hsa-miR-146b-5p EEPD1 2.23105707690238 3.83997814011313e-23 -0.121630595452844 0.464975157775222 miRanda -0.157698142236241 0.000123995113886488 NA NA NA hsa-miR-200a-3p EFCAB2 2.02394729844446 2.21240501925011e-08 -0.173043837634737 0.228827180508397 mirMAP -0.118875662240759 2.64119229769226e-07 NA NA NA hsa-miR-146b-3p EFCAB6 2.08650140817622 5.3293570720033e-22 -0.852515511473857 6.18719986267712e-05 MirTarget -0.375212316292812 4.06509981666693e-12 NA NA NA hsa-miR-146b-5p EFHC2 2.23105707690238 3.83997814011313e-23 -1.60142228063456 1.29196095814873e-06 miRanda -0.635546249595519 1.80563303021377e-15 NA NA NA hsa-miR-935 EFHD1 2.321600496365 1.00042201726114e-07 -0.728639754255346 0.00117715891580744 MirTarget;PITA;miRNATAP -0.194837479318299 8.04225559337903e-10 NA NA NA hsa-miR-200b-3p EFNA5 2.06025765178663 3.07718049337497e-10 -0.421335116813535 0.178679228276983 TargetScan -0.206540537480006 0.000230717411847866 NA NA NA hsa-miR-335-3p EFNA5 2.29463721765513 4.1956113745077e-18 -0.421335116813535 0.178679228276983 mirMAP -0.268047361383274 6.5851124205589e-05 NA NA NA hsa-miR-146b-5p EFR3B 2.23105707690238 3.83997814011313e-23 0.124382621165627 0.617197446990163 miRanda -0.242681606065779 7.8283366032566e-05 NA NA NA hsa-miR-192-5p EFR3B 2.0867723747501 3.57854249239079e-08 0.124382621165627 0.617197446990163 mirMAP -0.152510922352061 7.92137585494697e-05 NA NA NA hsa-miR-146b-5p EFS 2.23105707690238 3.83997814011313e-23 -1.63082426277518 2.22985086858025e-10 miRanda -0.454989968931181 9.56317518932279e-13 NA NA NA hsa-miR-141-5p EGFR 2.13747696823946 1.73124674554872e-11 -0.174568357475892 0.484508576205495 MirTarget -0.142032616039967 0.00197947705336657 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-146b-5p EGFR 2.23105707690238 3.83997814011313e-23 -0.174568357475892 0.484508576205495 miRNATAP -0.184260518729299 0.00299132496562976 NA NA NA hsa-miR-192-5p EGFR 2.0867723747501 3.57854249239079e-08 -0.174568357475892 0.484508576205495 mirMAP -0.101469705987116 0.00947566210441527 NA NA NA hsa-miR-200a-3p EGFR 2.02394729844446 2.21240501925011e-08 -0.174568357475892 0.484508576205495 MirTarget -0.149920239738882 0.000226081981008851 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-146b-5p EGLN3 2.23105707690238 3.83997814011313e-23 -0.945505498429762 9.79793512600466e-07 miRanda -0.190818559691999 9.03415628717304e-05 NA NA NA hsa-miR-335-3p EGLN3 2.29463721765513 4.1956113745077e-18 -0.945505498429762 9.79793512600466e-07 mirMAP -0.110771602170096 0.00930472809651438 NA NA NA hsa-miR-183-5p EGR1 2.08412478942637 1.08931431254487e-10 -1.19548185353943 2.58321740617567e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265319921884661 8.44246816462655e-09 NA NA NA hsa-miR-192-5p EGR1 2.0867723747501 3.57854249239079e-08 -1.19548185353943 2.58321740617567e-06 miRNAWalker2_validate -0.188229355580979 2.61936868526192e-06 NA NA NA hsa-miR-194-5p EGR2 2.24386881692218 9.35116329002209e-11 0.308772900851999 0.170793937693648 miRNATAP -0.124513045443978 0.00108588568456315 NA NA NA hsa-miR-200a-3p EGR2 2.02394729844446 2.21240501925011e-08 0.308772900851999 0.170793937693648 miRNATAP -0.161532591319429 9.79729241758941e-06 NA NA NA hsa-miR-146b-5p EGR3 2.23105707690238 3.83997814011313e-23 -0.979948930483222 0.000185818581104659 miRanda -0.220050716194573 0.000834750857935093 NA NA NA hsa-miR-200b-3p EGR3 2.06025765178663 3.07718049337497e-10 -0.979948930483222 0.000185818581104659 TargetScan -0.280465895520504 1.56313188426172e-09 NA NA NA hsa-miR-335-3p EGR3 2.29463721765513 4.1956113745077e-18 -0.979948930483222 0.000185818581104659 MirTarget -0.226396505793199 6.8090283871141e-05 NA NA NA hsa-miR-194-5p EHBP1 2.24386881692218 9.35116329002209e-11 -0.0772806546776623 0.5608418178024 MirTarget;miRNATAP -0.19686862127497 2.93848851824399e-21 NA NA NA hsa-miR-192-5p EHBP1L1 2.0867723747501 3.57854249239079e-08 -0.377076908313878 0.00297956695224553 miRNAWalker2_validate -0.141231904284581 1.43584840470881e-13 NA NA NA hsa-miR-146b-5p EHD3 2.23105707690238 3.83997814011313e-23 -0.483588881802445 0.0174698865893574 miRanda -0.160288632356704 0.00158209058767247 NA NA NA hsa-miR-200a-3p EHD3 2.02394729844446 2.21240501925011e-08 -0.483588881802445 0.0174698865893574 mirMAP -0.237797884280122 1.07846800247075e-13 NA NA NA hsa-miR-200a-5p EID1 2.19152245759943 3.17968183522514e-11 -0.629989817962262 9.57613031834507e-06 MirTarget -0.266018476015898 2.22650033134871e-31 NA NA NA hsa-miR-146b-5p EIF1AY 2.23105707690238 3.83997814011313e-23 -1.48760227489375 0.105001697564672 MirTarget;miRanda -0.493782136947845 0.0315879970299489 NA NA NA hsa-miR-146b-5p EIF1B 2.23105707690238 3.83997814011313e-23 -0.457069128095558 4.24280958609668e-07 miRanda -0.113059259370244 4.91312071831058e-07 NA NA NA hsa-miR-21-5p EIF4A2 2.21515015440792 6.0468197386674e-49 -0.382805867476675 0.000458178068034746 miRNAWalker2_validate;miRTarBase -0.117279159716951 0.00161150274188387 NA NA NA hsa-miR-194-5p EIF4E3 2.24386881692218 9.35116329002209e-11 -1.24277770218871 4.31281769728062e-12 miRNATAP -0.189860061628061 7.46158471493119e-10 NA NA NA hsa-miR-200a-3p EIF4E3 2.02394729844446 2.21240501925011e-08 -1.24277770218871 4.31281769728062e-12 mirMAP -0.221390216723092 4.06776644753922e-14 NA NA NA hsa-miR-200b-3p EIF4E3 2.06025765178663 3.07718049337497e-10 -1.24277770218871 4.31281769728062e-12 TargetScan -0.2451038959554 2.32931002112101e-14 NA NA NA hsa-miR-335-3p EIF4E3 2.29463721765513 4.1956113745077e-18 -1.24277770218871 4.31281769728062e-12 MirTarget;mirMAP -0.327717811556967 6.29827569244735e-18 NA NA NA hsa-miR-21-5p EIF4EBP2 2.21515015440792 6.0468197386674e-49 -0.315823877158708 0.000627369821832842 miRNAWalker2_validate -0.14295797939137 4.03805649840889e-06 NA NA NA hsa-miR-146b-5p EIF5A2 2.23105707690238 3.83997814011313e-23 0.0361693799295977 0.848626182749503 miRNATAP -0.120069848677576 0.0108708316626966 NA NA NA hsa-miR-18a-5p ELAVL3 2.04701000113742 1.30593450319289e-12 -1.03957466034495 0.0192603432906592 mirMAP -0.633409690407272 2.36152016421266e-13 NA NA NA hsa-miR-335-3p ELAVL3 2.29463721765513 4.1956113745077e-18 -1.03957466034495 0.0192603432906592 mirMAP -0.480583191492565 3.89112108571091e-07 NA NA NA hsa-miR-196a-5p ELAVL4 5.05945965885472 4.48343841468539e-25 -1.05201490861251 0.00375987986315775 MirTarget -0.193637107168891 3.07552597686294e-06 NA NA NA hsa-miR-196b-5p ELAVL4 4.51951031652328 7.04026169031626e-18 -1.05201490861251 0.00375987986315775 MirTarget -0.204767018948916 1.44966242291717e-07 NA NA NA hsa-miR-200b-3p ELAVL4 2.06025765178663 3.07718049337497e-10 -1.05201490861251 0.00375987986315775 TargetScan -0.488517170097894 5.94251871262108e-15 NA NA NA hsa-miR-21-5p ELAVL4 2.21515015440792 6.0468197386674e-49 -1.05201490861251 0.00375987986315775 miRNAWalker2_validate -0.597052178130805 1.02552347405006e-06 NA NA NA hsa-miR-335-3p ELAVL4 2.29463721765513 4.1956113745077e-18 -1.05201490861251 0.00375987986315775 mirMAP -0.341169679723636 1.25214779254386e-05 NA NA NA hsa-miR-200b-3p ELK3 2.06025765178663 3.07718049337497e-10 0.186740798453513 0.188175135041682 TargetScan -0.127862338479325 3.25323092584741e-07 NA NA NA hsa-miR-335-3p ELK3 2.29463721765513 4.1956113745077e-18 0.186740798453513 0.188175135041682 MirTarget -0.106832902344161 0.000448093531667332 NA NA NA hsa-miR-141-5p ELL2 2.13747696823946 1.73124674554872e-11 -1.46362215725712 1.58717825670906e-20 MirTarget -0.192489847812306 2.53015039307021e-10 NA NA NA hsa-miR-146b-5p ELL2 2.23105707690238 3.83997814011313e-23 -1.46362215725712 1.58717825670906e-20 miRanda -0.229476270930552 3.13807402047988e-08 NA NA NA hsa-miR-192-5p ELL2 2.0867723747501 3.57854249239079e-08 -1.46362215725712 1.58717825670906e-20 miRNAWalker2_validate -0.196449840616178 9.97331759997534e-15 NA NA NA hsa-miR-200b-3p ELL2 2.06025765178663 3.07718049337497e-10 -1.46362215725712 1.58717825670906e-20 MirTarget;TargetScan -0.20684374064257 2.10091962941171e-12 NA NA NA hsa-miR-335-3p ELL2 2.29463721765513 4.1956113745077e-18 -1.46362215725712 1.58717825670906e-20 mirMAP -0.296453755212341 9.52687858932377e-18 NA NA NA hsa-miR-192-5p ELMO1 2.0867723747501 3.57854249239079e-08 0.0395249546802692 0.831473675303198 MirTarget -0.11500043338878 6.5137337942527e-05 NA NA NA hsa-miR-335-3p ELMO1 2.29463721765513 4.1956113745077e-18 0.0395249546802692 0.831473675303198 MirTarget -0.152545495523088 0.000123828913693874 NA NA NA hsa-miR-146b-3p ELN 2.08650140817622 5.3293570720033e-22 0.450852117594454 0.137523355283542 miRNATAP -0.207753553772611 0.00874258882531715 NA NA NA hsa-miR-21-5p ELOVL4 2.21515015440792 6.0468197386674e-49 -1.19952854478656 1.99479557964071e-05 miRNAWalker2_validate -0.608559626101489 9.014665489221e-11 NA NA NA hsa-miR-192-5p ELOVL5 2.0867723747501 3.57854249239079e-08 -0.0910045021719972 0.633667869483248 miRNAWalker2_validate -0.209795049625131 2.16570286132685e-13 NA NA NA hsa-miR-335-3p ELOVL5 2.29463721765513 4.1956113745077e-18 -0.0910045021719972 0.633667869483248 mirMAP -0.152842684803972 0.000186387504339132 NA NA NA hsa-miR-194-5p EMCN 2.24386881692218 9.35116329002209e-11 -0.471102048095636 0.0163060262265431 MirTarget -0.182885957939837 2.06244876520223e-08 NA NA NA hsa-miR-335-3p EMCN 2.29463721765513 4.1956113745077e-18 -0.471102048095636 0.0163060262265431 mirMAP -0.299057996355535 1.98010669092162e-13 NA NA NA hsa-miR-146b-5p EMILIN3 2.23105707690238 3.83997814011313e-23 -0.963932964050575 8.89592314814731e-09 miRanda -0.18434243916377 1.43885177227968e-05 NA NA NA hsa-miR-192-5p EML1 2.0867723747501 3.57854249239079e-08 -1.03848400994716 8.54789799498598e-05 miRNAWalker2_validate -0.391321229609126 2.24377940678663e-24 NA NA NA hsa-miR-21-5p EMP2 2.21515015440792 6.0468197386674e-49 -0.423339311440701 0.0098539999159188 mirMAP -0.159077616744799 0.00437243103633848 NA NA NA hsa-miR-335-3p EMP2 2.29463721765513 4.1956113745077e-18 -0.423339311440701 0.0098539999159188 mirMAP -0.11050752065579 0.0018342904351565 NA NA NA hsa-miR-183-5p ENAH 2.08412478942637 1.08931431254487e-10 -0.303508505660234 0.0898566571919018 miRNATAP -0.247975826609513 1.01019110884117e-15 NA NA NA hsa-miR-194-5p ENAH 2.24386881692218 9.35116329002209e-11 -0.303508505660234 0.0898566571919018 mirMAP;miRNATAP -0.148799878446689 6.20567578425262e-07 NA NA NA hsa-miR-21-5p ENAH 2.21515015440792 6.0468197386674e-49 -0.303508505660234 0.0898566571919018 miRNAWalker2_validate;mirMAP -0.279307247856932 3.14847372848835e-06 NA NA NA hsa-miR-335-3p ENAM 2.29463721765513 4.1956113745077e-18 -2.42908610218569 3.73983836329971e-08 mirMAP -0.657676907055398 3.08101682569147e-12 NA NA NA hsa-miR-133a-3p ENC1 -2.63342156915404 5.72661351480585e-12 1.9765756791273 2.14331146580439e-22 MirTarget -0.169719076095415 3.30931450081702e-07 NA NA NA hsa-miR-192-5p ENDOD1 2.0867723747501 3.57854249239079e-08 -0.311613833349303 0.0226809514564935 miRNAWalker2_validate -0.101360061412654 1.60841216302576e-06 NA NA NA hsa-miR-200b-3p ENO4 2.06025765178663 3.07718049337497e-10 -0.0764106614618993 0.676633985058579 MirTarget -0.124955932751048 0.000130683896269623 NA NA NA hsa-miR-335-3p ENOX1 2.29463721765513 4.1956113745077e-18 -0.222053707738944 0.397488559364641 mirMAP -0.315076530751338 1.23280187980154e-08 NA NA NA hsa-miR-200b-3p ENPEP 2.06025765178663 3.07718049337497e-10 0.228675607440872 0.387361286176117 mirMAP -0.109471058713844 0.0216422778672196 NA NA NA hsa-miR-146b-5p ENPP3 2.23105707690238 3.83997814011313e-23 -2.67304931835674 6.30263971852467e-12 miRanda -0.604137270777365 8.07655190361823e-10 NA NA NA hsa-miR-135b-5p ENTPD1 2.80066701698235 2.12546333413447e-11 0.236680596078842 0.0602010987065912 mirMAP -0.115411569982459 1.05073581452074e-10 NA NA NA hsa-miR-200a-5p ENTPD1 2.19152245759943 3.17968183522514e-11 0.236680596078842 0.0602010987065912 mirMAP -0.167281092019876 3.28624742790681e-15 NA NA NA hsa-miR-200b-3p ENTPD1 2.06025765178663 3.07718049337497e-10 0.236680596078842 0.0602010987065912 MirTarget;mirMAP -0.167649822146323 6.91874315866771e-15 NA NA NA hsa-miR-335-3p ENTPD1 2.29463721765513 4.1956113745077e-18 0.236680596078842 0.0602010987065912 mirMAP -0.142546283882175 8.57168006093514e-08 NA NA NA hsa-miR-192-5p ENTPD3 2.0867723747501 3.57854249239079e-08 -2.57455302613472 2.46343986336398e-11 miRNAWalker2_validate -0.2857339057772 4.24381139285329e-06 NA NA NA hsa-miR-200a-3p EPB41L3 2.02394729844446 2.21240501925011e-08 -1.19294977368621 1.44160669187151e-07 miRNATAP -0.268410884723157 1.81611802410153e-13 NA NA NA hsa-miR-141-5p EPDR1 2.13747696823946 1.73124674554872e-11 -0.267558637525019 0.269780074713144 MirTarget -0.247275235037108 1.49835552655579e-08 NA NA NA hsa-miR-192-5p EPDR1 2.0867723747501 3.57854249239079e-08 -0.267558637525019 0.269780074713144 miRNAWalker2_validate -0.112662647482773 0.00296853631235063 NA NA NA hsa-miR-194-5p EPHA3 2.24386881692218 9.35116329002209e-11 0.184866448700745 0.535876012219245 miRNATAP -0.243241728152027 1.0470776955437e-06 NA NA NA hsa-miR-196a-5p EPHA3 5.05945965885472 4.48343841468539e-25 0.184866448700745 0.535876012219245 MirTarget -0.116624654026015 0.000648424344414213 NA NA NA hsa-miR-196b-5p EPHA3 4.51951031652328 7.04026169031626e-18 0.184866448700745 0.535876012219245 MirTarget -0.155062353296751 1.16648228805284e-06 NA NA NA hsa-miR-183-5p EPHA4 2.08412478942637 1.08931431254487e-10 -0.721045772095589 0.00956988810687138 miRNATAP -0.363168679791924 8.62444558209429e-14 NA NA NA hsa-miR-200a-3p EPHA4 2.02394729844446 2.21240501925011e-08 -0.721045772095589 0.00956988810687138 mirMAP -0.401859455270762 3.25549046352664e-21 NA NA NA hsa-miR-21-5p EPHA4 2.21515015440792 6.0468197386674e-49 -0.721045772095589 0.00956988810687138 miRNAWalker2_validate;miRNATAP -0.416201980009361 9.19477583509674e-06 NA NA NA hsa-miR-335-3p EPHA4 2.29463721765513 4.1956113745077e-18 -0.721045772095589 0.00956988810687138 mirMAP -0.258918168665723 1.47615097898863e-05 NA NA NA hsa-miR-146b-5p EPHA5 2.23105707690238 3.83997814011313e-23 -0.957355977960908 0.0173317346329917 MirTarget;miRanda -0.561428913727234 1.13502309463674e-08 NA NA NA hsa-miR-194-5p EPHA5 2.24386881692218 9.35116329002209e-11 -0.957355977960908 0.0173317346329917 MirTarget -0.432438210540457 6.96764816166721e-11 NA NA NA hsa-miR-200a-5p EPHA5 2.19152245759943 3.17968183522514e-11 -0.957355977960908 0.0173317346329917 MirTarget;miRNATAP -0.558475585047588 1.92221953970227e-16 NA NA NA hsa-miR-200b-3p EPHA5 2.06025765178663 3.07718049337497e-10 -0.957355977960908 0.0173317346329917 MirTarget -0.528457075103002 2.57481653349712e-14 NA NA NA hsa-miR-335-3p EPHA5 2.29463721765513 4.1956113745077e-18 -0.957355977960908 0.0173317346329917 mirMAP -0.361154479322503 2.95575162660125e-05 NA NA NA hsa-miR-18a-5p EPHA7 2.04701000113742 1.30593450319289e-12 -2.19739166323181 3.30440512414909e-05 miRNATAP -0.872184498825992 1.62704346256535e-17 NA NA NA hsa-miR-196a-5p EPHA7 5.05945965885472 4.48343841468539e-25 -2.19739166323181 3.30440512414909e-05 miRNAWalker2_validate;miRNATAP -0.39939634241845 2.29377801567576e-11 NA NA NA hsa-miR-196b-5p EPHA7 4.51951031652328 7.04026169031626e-18 -2.19739166323181 3.30440512414909e-05 miRNATAP -0.407641666656324 3.09955398940882e-13 NA NA NA hsa-miR-200a-3p EPHA7 2.02394729844446 2.21240501925011e-08 -2.19739166323181 3.30440512414909e-05 miRNATAP -0.781358058705133 9.2707913073816e-22 NA NA NA hsa-miR-141-5p EPHX1 2.13747696823946 1.73124674554872e-11 -1.24741528638924 5.76556215618187e-16 MirTarget -0.134319961818947 6.30266049484524e-06 NA NA NA hsa-miR-146b-5p EPHX2 2.23105707690238 3.83997814011313e-23 -1.30528222081473 1.30980172602295e-07 miRanda -0.197979759153784 0.00167812231554924 NA NA NA hsa-miR-192-5p EPM2A 2.0867723747501 3.57854249239079e-08 -1.00729583125 1.98879330342911e-07 miRNAWalker2_validate -0.339687396633476 6.28341444958103e-36 NA NA NA hsa-miR-21-5p EPM2A 2.21515015440792 6.0468197386674e-49 -1.00729583125 1.98879330342911e-07 miRNAWalker2_validate -0.598076009274688 6.95318033824996e-22 NA NA NA hsa-miR-192-5p EPM2AIP1 2.0867723747501 3.57854249239079e-08 -0.374479682925325 0.0526272510372513 miRNAWalker2_validate -0.221592516986378 1.74137463631655e-14 NA NA NA hsa-miR-200a-5p EPM2AIP1 2.19152245759943 3.17968183522514e-11 -0.374479682925325 0.0526272510372513 MirTarget -0.251347297046236 1.69399372182796e-14 NA NA NA hsa-miR-21-5p EPM2AIP1 2.21515015440792 6.0468197386674e-49 -0.374479682925325 0.0526272510372513 mirMAP -0.157022619799312 0.0169742224316651 NA NA NA hsa-miR-335-3p EPM2AIP1 2.29463721765513 4.1956113745077e-18 -0.374479682925325 0.0526272510372513 mirMAP -0.193323835036976 2.72700997972091e-06 NA NA NA hsa-miR-935 EPM2AIP1 2.321600496365 1.00042201726114e-07 -0.374479682925325 0.0526272510372513 MirTarget;PITA -0.154912047782565 1.28341775741638e-08 NA NA NA hsa-miR-146b-5p EPS15L1 2.23105707690238 3.83997814011313e-23 -0.210792741132925 0.00193282366749872 miRanda -0.100538466723165 7.840513647504e-10 NA NA NA hsa-miR-141-5p ERBB4 2.13747696823946 1.73124674554872e-11 -1.97496082958559 1.58728422015894e-05 MirTarget -0.31819251462369 0.000191252253065843 NA NA NA hsa-miR-146b-5p ERBB4 2.23105707690238 3.83997814011313e-23 -1.97496082958559 1.58728422015894e-05 PITA;miRNATAP -0.642630005374273 1.3974342074184e-08 NA NA NA hsa-miR-194-5p ERBB4 2.24386881692218 9.35116329002209e-11 -1.97496082958559 1.58728422015894e-05 miRNATAP -0.23250211980301 0.00317493786730366 NA NA NA hsa-miR-200a-5p ERBB4 2.19152245759943 3.17968183522514e-11 -1.97496082958559 1.58728422015894e-05 mirMAP;miRNATAP -0.341618301016301 3.02267048857911e-05 NA NA NA hsa-miR-200b-3p ERBB4 2.06025765178663 3.07718049337497e-10 -1.97496082958559 1.58728422015894e-05 TargetScan -0.312066132439956 0.000176442888096672 NA NA NA hsa-miR-183-5p ERC1 2.08412478942637 1.08931431254487e-10 -0.107831770859248 0.387937444516273 miRNAWalker2_validate -0.161563273167404 8.35134459272146e-14 NA NA NA hsa-miR-200b-3p ERC1 2.06025765178663 3.07718049337497e-10 -0.107831770859248 0.387937444516273 TargetScan;mirMAP -0.200523473595961 2.81187064500887e-22 NA NA NA hsa-miR-335-3p ERC1 2.29463721765513 4.1956113745077e-18 -0.107831770859248 0.387937444516273 mirMAP -0.114870458183829 1.54459962981683e-05 NA NA NA hsa-miR-200a-3p ERC2 2.02394729844446 2.21240501925011e-08 -0.427257459724932 0.15521309382104 MirTarget -0.271057008139225 1.8710212623803e-08 NA NA NA hsa-miR-335-3p ERC2 2.29463721765513 4.1956113745077e-18 -0.427257459724932 0.15521309382104 MirTarget -0.143694606627101 0.0273658356091437 NA NA NA hsa-miR-194-5p ERG 2.24386881692218 9.35116329002209e-11 0.00212829554190064 0.990109995094702 MirTarget -0.144305995198841 4.27722627502493e-07 NA NA NA hsa-miR-200a-3p ERG 2.02394729844446 2.21240501925011e-08 0.00212829554190064 0.990109995094702 MirTarget -0.212981077830277 1.25453886458797e-15 NA NA NA hsa-miR-200b-3p ERG 2.06025765178663 3.07718049337497e-10 0.00212829554190064 0.990109995094702 TargetScan -0.222000071451755 4.46970236013955e-14 27191272 The tumor suppressive miR 200b subfamily is an ERG target gene in human prostate tumors; Although induction of the tumor suppressive miR-200b subfamily by oncogenic ERG appears to be counterintuitive it is consistent with the observation that the vast majority of primary prostate cancers are slow-growing and indolent prostate cancer hsa-miR-146b-5p ERRFI1 2.23105707690238 3.83997814011313e-23 -0.797991095855851 8.16500395108496e-06 miRanda -0.275800542866361 3.51658259586025e-10 NA NA NA hsa-miR-18a-5p ERRFI1 2.04701000113742 1.30593450319289e-12 -0.797991095855851 8.16500395108496e-06 miRNAWalker2_validate -0.222270710965566 4.889617965357e-10 NA NA NA hsa-miR-200b-3p ERRFI1 2.06025765178663 3.07718049337497e-10 -0.797991095855851 8.16500395108496e-06 MirTarget;TargetScan -0.255031617869948 1.61384134408975e-16 NA NA NA hsa-miR-18a-5p ESR1 2.04701000113742 1.30593450319289e-12 -1.03540584472649 2.65202027022478e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.428841610453799 1.07620378964708e-19 19027010;24975878 MicroRNA 18a prevents estrogen receptor alpha expression promoting proliferation of hepatocellular carcinoma cells; The gene ESR1 which encodes the estrogen receptor-alpha ERalpha was identified as a target of miR-18a miR-18a can repress ERalpha translation by binding to its mRNA at the 3' untranslated region;Elevated p53 promotes the processing of miR 18a to decrease estrogen receptor α in female hepatocellular carcinoma; Our previous study identified that estrogen receptor alpha ERα protein is downregulated in 60% of female HCC cases via a miR-18a elevation mediated suppression of ERα translation ; liver cancer;liver cancer hsa-miR-335-3p ESRRB 2.29463721765513 4.1956113745077e-18 -1.76272355630239 1.65549464311203e-06 mirMAP -0.401588478508271 4.77323686355471e-07 NA NA NA hsa-miR-141-5p ESRRG 2.13747696823946 1.73124674554872e-11 -4.81883837531082 5.12622713493389e-21 miRNATAP -0.367988105353346 0.000303962782902363 NA NA NA hsa-miR-200a-3p ESRRG 2.02394729844446 2.21240501925011e-08 -4.81883837531082 5.12622713493389e-21 miRNATAP -0.227113912500646 0.0126983969323891 NA NA NA hsa-miR-200b-3p ESRRG 2.06025765178663 3.07718049337497e-10 -4.81883837531082 5.12622713493389e-21 TargetScan -0.310232569677695 0.0018627473269641 NA NA NA hsa-miR-335-3p ESRRG 2.29463721765513 4.1956113745077e-18 -4.81883837531082 5.12622713493389e-21 mirMAP -0.715718242702382 8.28757834689297e-10 NA NA NA hsa-miR-335-3p ETFDH 2.29463721765513 4.1956113745077e-18 -1.31175183340672 1.54614681862669e-20 mirMAP -0.172794221067904 8.40853257331194e-08 NA NA NA hsa-miR-335-3p ETV1 2.29463721765513 4.1956113745077e-18 -0.095537921341216 0.676735917831981 MirTarget;mirMAP -0.103048155254098 0.0375959113726899 NA NA NA hsa-miR-146b-5p ETV3 2.23105707690238 3.83997814011313e-23 -0.413749009581045 0.000519333055951698 miRanda -0.118267640357399 6.61538584089505e-05 NA NA NA hsa-miR-92a-1-5p EVC 2.04820501765632 9.32117486799495e-13 -0.466070856068544 0.0516818136782104 mirMAP -0.284112849660879 4.80639292730738e-09 NA NA NA hsa-miR-200a-3p EVI5L 2.02394729844446 2.21240501925011e-08 -0.746871114366363 4.34714157926662e-10 MirTarget;miRNATAP -0.12438024439419 2.34589409895535e-10 NA NA NA hsa-miR-192-5p EXTL2 2.0867723747501 3.57854249239079e-08 0.109243729813074 0.373750128185246 miRNAWalker2_validate -0.131604424129497 8.32060354897344e-13 NA NA NA hsa-miR-146b-3p EXTL3 2.08650140817622 5.3293570720033e-22 0.108697019640584 0.406259153942836 MirTarget;miRNATAP -0.124859980037353 0.000218527592725961 NA NA NA hsa-miR-194-5p EYA4 2.24386881692218 9.35116329002209e-11 0.300366807020702 0.36876153821282 miRNATAP -0.2169413888942 0.0001150878596213 NA NA NA hsa-miR-335-3p EYA4 2.29463721765513 4.1956113745077e-18 0.300366807020702 0.36876153821282 MirTarget -0.198718308174244 0.00588283018581919 NA NA NA hsa-miR-146b-5p F11 2.23105707690238 3.83997814011313e-23 -2.32373258937023 3.09393055510958e-05 miRanda -0.429620359459887 0.00229665413087637 NA NA NA hsa-miR-146b-5p FABP4 2.23105707690238 3.83997814011313e-23 -2.93355092437698 1.19836855118567e-10 miRanda -0.532524093194354 4.76427538811704e-06 NA NA NA hsa-miR-141-5p FADS1 2.13747696823946 1.73124674554872e-11 0.270403268873646 0.21340410024689 MirTarget -0.177945341530774 6.95087646657567e-06 NA NA NA hsa-miR-192-5p FADS1 2.0867723747501 3.57854249239079e-08 0.270403268873646 0.21340410024689 miRNAWalker2_validate -0.135471574739071 5.99581640159027e-05 NA NA NA hsa-miR-146b-5p FAH 2.23105707690238 3.83997814011313e-23 -0.45664847745582 0.00788586821365597 miRanda -0.15891432247699 0.000199909715673004 NA NA NA hsa-miR-141-5p FAIM2 2.13747696823946 1.73124674554872e-11 -1.4002661091018 5.79765065952614e-05 mirMAP -0.374092730794766 3.84375265148818e-09 NA NA NA hsa-miR-18a-5p FAIM2 2.04701000113742 1.30593450319289e-12 -1.4002661091018 5.79765065952614e-05 mirMAP -0.32560078115045 3.91942748307419e-06 NA NA NA hsa-miR-146b-5p FAM110B 2.23105707690238 3.83997814011313e-23 -1.10453149128806 1.21017749000064e-05 miRanda -0.414288276623228 1.9211697471633e-11 NA NA NA hsa-miR-183-5p FAM110B 2.08412478942637 1.08931431254487e-10 -1.10453149128806 1.21017749000064e-05 miRNAWalker2_validate -0.349349194127216 3.64917454821309e-15 NA NA NA hsa-miR-335-3p FAM110B 2.29463721765513 4.1956113745077e-18 -1.10453149128806 1.21017749000064e-05 mirMAP -0.33249680429379 6.64940059074798e-10 NA NA NA hsa-miR-133a-3p FAM117B -2.63342156915404 5.72661351480585e-12 0.424050863265434 0.000673249458653046 MirTarget -0.115446525840455 6.06129647214431e-10 NA NA NA hsa-miR-18a-5p FAM120C 2.04701000113742 1.30593450319289e-12 0.170776103390755 0.263203241775743 miRNAWalker2_validate;MirTarget -0.126024114428764 3.6717799385452e-05 NA NA NA hsa-miR-200b-3p FAM120C 2.06025765178663 3.07718049337497e-10 0.170776103390755 0.263203241775743 mirMAP -0.181177471371487 6.80944248563842e-12 NA NA NA hsa-miR-146b-5p FAM122A 2.23105707690238 3.83997814011313e-23 -0.303994263706123 0.000409216969430765 miRanda -0.126855775181587 1.24776156630245e-09 NA NA NA hsa-miR-335-3p FAM122A 2.29463721765513 4.1956113745077e-18 -0.303994263706123 0.000409216969430765 MirTarget;mirMAP -0.114996487486519 1.84435101167154e-10 NA NA NA hsa-miR-192-5p FAM126A 2.0867723747501 3.57854249239079e-08 -0.0664935237033619 0.72412799652184 miRNAWalker2_validate -0.105399370799883 0.000321347632662215 NA NA NA hsa-miR-200b-3p FAM126A 2.06025765178663 3.07718049337497e-10 -0.0664935237033619 0.72412799652184 TargetScan -0.136391539391253 4.75362747304217e-05 NA NA NA hsa-miR-335-3p FAM126A 2.29463721765513 4.1956113745077e-18 -0.0664935237033619 0.72412799652184 MirTarget -0.107797079150681 0.00794747123439137 NA NA NA hsa-miR-196a-5p FAM127A 5.05945965885472 4.48343841468539e-25 -0.726381248486746 0.000138289728116872 miRNAWalker2_validate -0.123512472441336 1.18778620051509e-08 NA NA NA hsa-miR-18a-5p FAM127B 2.04701000113742 1.30593450319289e-12 -0.561735132927407 0.00941023505557202 miRNAWalker2_validate -0.150231487519424 0.000601013708238945 NA NA NA hsa-miR-146b-5p FAM129A 2.23105707690238 3.83997814011313e-23 -1.53140169859557 6.69778433475266e-07 miRanda -0.573591833003932 1.76172137941902e-14 NA NA NA hsa-miR-200a-3p FAM133A 2.02394729844446 2.21240501925011e-08 0.548783809174174 0.290090231292157 mirMAP -0.491121391197126 3.1119399749824e-09 NA NA NA hsa-miR-146b-5p FAM135B 2.23105707690238 3.83997814011313e-23 -3.9783501981353 1.04908699816689e-18 miRanda -0.776573154719438 2.55511730065543e-11 NA NA NA hsa-miR-200a-3p FAM135B 2.02394729844446 2.21240501925011e-08 -3.9783501981353 1.04908699816689e-18 mirMAP -0.312025187271373 7.3228940934328e-05 NA NA NA hsa-miR-146b-5p FAM149A 2.23105707690238 3.83997814011313e-23 -1.40583573151163 2.71857180719039e-07 miRanda -0.515080082525449 8.60321828781216e-15 NA NA NA hsa-miR-335-3p FAM150B 2.29463721765513 4.1956113745077e-18 -2.23525980620691 2.01081717667411e-13 MirTarget -0.321001973548514 2.38940773775948e-06 NA NA NA hsa-miR-200b-3p FAM153A 2.06025765178663 3.07718049337497e-10 -1.88948384658455 1.58081589858539e-05 mirMAP -0.380939702432362 1.37646143459624e-06 NA NA NA hsa-miR-92a-1-5p FAM155B 2.04820501765632 9.32117486799495e-13 -1.26571802380298 0.0241498406500018 MirTarget -0.311854446024868 0.0076628686056272 NA NA NA hsa-miR-335-3p FAM161B 2.29463721765513 4.1956113745077e-18 -1.07487918407563 1.29095804066764e-14 mirMAP -0.233817251648354 9.69934119516466e-15 NA NA NA hsa-miR-18a-5p FAM166B 2.04701000113742 1.30593450319289e-12 -0.77049285258883 7.10904042930129e-06 MirTarget -0.147562923801102 2.40706837106741e-05 NA NA NA hsa-miR-18a-5p FAM168A 2.04701000113742 1.30593450319289e-12 -0.191804273695932 0.128925621940858 mirMAP -0.16195713100713 5.03579786967121e-11 NA NA NA hsa-miR-146b-5p FAM168B 2.23105707690238 3.83997814011313e-23 -0.135313494128928 0.193723824290666 MirTarget;miRanda -0.1735574917462 2.69156373524389e-12 NA NA NA hsa-miR-200a-3p FAM168B 2.02394729844446 2.21240501925011e-08 -0.135313494128928 0.193723824290666 MirTarget -0.10765853346969 5.47778020915746e-11 NA NA NA hsa-miR-200b-3p FAM168B 2.06025765178663 3.07718049337497e-10 -0.135313494128928 0.193723824290666 TargetScan -0.110399625337369 1.11375152311079e-09 NA NA NA hsa-miR-183-5p FAM169B 2.08412478942637 1.08931431254487e-10 0.0699614531709973 0.8857984123946 mirMAP -0.179834836087068 0.0431027114463225 NA NA NA hsa-miR-192-5p FAM171B 2.0867723747501 3.57854249239079e-08 -0.0176591718289498 0.927528339765729 miRNAWalker2_validate -0.188557307480295 1.43845162990559e-10 NA NA NA hsa-miR-146b-5p FAM174A 2.23105707690238 3.83997814011313e-23 -0.884630141873353 1.57767247994561e-09 miRanda -0.162203518147993 1.32527665991198e-05 NA NA NA hsa-miR-146b-5p FAM174B 2.23105707690238 3.83997814011313e-23 -0.728702970899721 0.00170845431667668 miRanda -0.294991819519385 2.60736515419759e-07 NA NA NA hsa-miR-146b-5p FAM179B 2.23105707690238 3.83997814011313e-23 -0.167488194439022 0.19857804382265 miRanda -0.123884424449328 0.000115613824666263 NA NA NA hsa-miR-200b-3p FAM179B 2.06025765178663 3.07718049337497e-10 -0.167488194439022 0.19857804382265 TargetScan -0.11893603875181 2.18362927380513e-07 NA NA NA hsa-miR-141-5p FAM188A 2.13747696823946 1.73124674554872e-11 -0.440254863510343 0.000176623974619799 MirTarget -0.127218728665572 2.12614372490348e-09 NA NA NA hsa-miR-183-5p FAM189A1 2.08412478942637 1.08931431254487e-10 -2.65743696971689 6.59320514962127e-07 mirMAP -0.615583290486251 1.74148659931548e-10 NA NA NA hsa-miR-192-5p FAM189A2 2.0867723747501 3.57854249239079e-08 -2.26859785003332 8.09998388383058e-08 miRNAWalker2_validate -0.229625668198354 0.000701137734357473 NA NA NA hsa-miR-146b-5p FAM196A 2.23105707690238 3.83997814011313e-23 -0.288120566953572 0.21491857896918 MirTarget;miRanda -0.11961929362842 0.0393221170253606 NA NA NA hsa-miR-18a-5p FAM196A 2.04701000113742 1.30593450319289e-12 -0.288120566953572 0.21491857896918 MirTarget -0.15917475050099 0.000673193042531376 NA NA NA hsa-miR-335-3p FAM196A 2.29463721765513 4.1956113745077e-18 -0.288120566953572 0.21491857896918 mirMAP -0.149574101818852 0.00282861320762379 NA NA NA hsa-miR-335-3p FAM198B 2.29463721765513 4.1956113745077e-18 0.708011145533439 0.000110925970709765 mirMAP -0.102033983656821 0.0108613564634093 NA NA NA hsa-miR-200b-3p FAM19A2 2.06025765178663 3.07718049337497e-10 -0.377165351670982 0.0986545816303479 MirTarget -0.108173629051001 0.008571417429971 NA NA NA hsa-miR-200b-3p FAM19A5 2.06025765178663 3.07718049337497e-10 1.69117921336791 2.05488338044706e-09 TargetScan -0.190811529691732 0.000253191322318827 NA NA NA hsa-miR-192-5p FAM20B 2.0867723747501 3.57854249239079e-08 0.0115906902718228 0.915994905003775 miRNAWalker2_validate -0.119288009804203 3.46163894348874e-13 NA NA NA hsa-miR-21-5p FAM20B 2.21515015440792 6.0468197386674e-49 0.0115906902718228 0.915994905003775 miRNAWalker2_validate -0.122706915846483 0.000892710911420458 NA NA NA hsa-miR-200a-3p FAM20C 2.02394729844446 2.21240501925011e-08 -0.0640241959216761 0.731096905274497 MirTarget -0.218712769902904 5.69035059269419e-14 NA NA NA hsa-miR-335-3p FAM210B 2.29463721765513 4.1956113745077e-18 -0.0682805098817587 0.652570872183836 MirTarget -0.110968962663499 0.000644082293404556 NA NA NA hsa-miR-92a-1-5p FAM212B 2.04820501765632 9.32117486799495e-13 -0.999900600735786 4.86315864880706e-07 MirTarget -0.271122466369765 2.65406672988165e-11 NA NA NA hsa-miR-335-3p FAM218A 2.29463721765513 4.1956113745077e-18 -1.00385194642629 0.00230668056961469 mirMAP -0.403043997689435 8.43874954900603e-09 NA NA NA hsa-miR-200b-3p FAM219A 2.06025765178663 3.07718049337497e-10 0.218628262317111 0.0484705408275253 TargetScan -0.118620189848456 8.43793659422667e-10 NA NA NA hsa-miR-192-5p FAM26E 2.0867723747501 3.57854249239079e-08 1.01953327801786 8.03296050259027e-07 mirMAP -0.11780695145933 0.000340646704555298 NA NA NA hsa-miR-200a-3p FAM26E 2.02394729844446 2.21240501925011e-08 1.01953327801786 8.03296050259027e-07 mirMAP -0.189031609967428 2.26732662887113e-08 NA NA NA hsa-miR-200a-5p FAM26E 2.19152245759943 3.17968183522514e-11 1.01953327801786 8.03296050259027e-07 mirMAP -0.163331561776476 1.04456266256617e-05 NA NA NA hsa-miR-200b-3p FAM26E 2.06025765178663 3.07718049337497e-10 1.01953327801786 8.03296050259027e-07 mirMAP -0.186673104871618 5.74433463414189e-07 NA NA NA hsa-miR-146b-5p FAM46A 2.23105707690238 3.83997814011313e-23 -0.731253149491049 4.51804141138159e-05 PITA;miRanda -0.113571706091611 0.0121750145757085 NA NA NA hsa-miR-21-5p FAM46A 2.21515015440792 6.0468197386674e-49 -0.731253149491049 4.51804141138159e-05 miRNAWalker2_validate;miRNATAP -0.192775115940049 0.0017226388588753 NA NA NA hsa-miR-335-3p FAM46A 2.29463721765513 4.1956113745077e-18 -0.731253149491049 4.51804141138159e-05 mirMAP -0.141188799502547 0.000296282149462177 NA NA NA hsa-miR-146b-5p FAM47E 2.23105707690238 3.83997814011313e-23 -0.514302431413817 0.000592456215185531 miRanda -0.227683875707858 4.40068121955961e-10 NA NA NA hsa-miR-335-3p FAM49A 2.29463721765513 4.1956113745077e-18 -0.869697448424034 4.55061021297749e-05 MirTarget -0.377990973710453 7.28310369939265e-18 NA NA NA hsa-miR-146b-5p FAM53C 2.23105707690238 3.83997814011313e-23 -0.270499646067444 0.000987040436758781 miRanda -0.103892907220076 2.27894526168378e-07 NA NA NA hsa-miR-133a-3p FAM57A -2.63342156915404 5.72661351480585e-12 0.302468287845588 0.0400432403525307 MirTarget -0.125377027120551 1.26227911218042e-08 NA NA NA hsa-miR-192-5p FAM63B 2.0867723747501 3.57854249239079e-08 0.0653334389343767 0.616352094767286 miRNAWalker2_validate -0.166127913589892 3.31128427701621e-18 NA NA NA hsa-miR-194-5p FAM63B 2.24386881692218 9.35116329002209e-11 0.0653334389343767 0.616352094767286 miRNATAP -0.140819072624581 3.63475425635453e-11 NA NA NA hsa-miR-200b-3p FAM63B 2.06025765178663 3.07718049337497e-10 0.0653334389343767 0.616352094767286 TargetScan -0.122069457785558 9.85615708532093e-08 NA NA NA hsa-miR-335-3p FAM63B 2.29463721765513 4.1956113745077e-18 0.0653334389343767 0.616352094767286 mirMAP -0.129749724185474 2.71643326164221e-06 NA NA NA hsa-miR-192-5p FAM83D 2.0867723747501 3.57854249239079e-08 0.190720348515486 0.389470030829468 miRNAWalker2_validate -0.256050219801128 8.91661096170149e-15 NA NA NA hsa-miR-200b-3p FAM8A1 2.06025765178663 3.07718049337497e-10 -0.222229045123044 0.0265174303093394 TargetScan -0.107500577717425 7.52592007226654e-10 NA NA NA hsa-miR-1-3p FAM91A1 -2.73171785118192 3.4424534921136e-12 1.06327192404646 3.8051602601026e-18 MirTarget -0.176405994757782 5.75872484328089e-23 NA NA NA hsa-miR-146b-3p FARP1 2.08650140817622 5.3293570720033e-22 0.504657815201534 0.00187642310069963 MirTarget;miRNATAP -0.108703053101698 0.0107124581417579 NA NA NA hsa-miR-200b-3p FARP1 2.06025765178663 3.07718049337497e-10 0.504657815201534 0.00187642310069963 TargetScan -0.101546671329369 0.000518669775416538 NA NA NA hsa-miR-183-5p FAT2 2.08412478942637 1.08931431254487e-10 -0.278356365218703 0.44877423623627 miRNAWalker2_validate -0.154197493953449 0.0213965039338374 NA NA NA hsa-miR-135b-5p FAT3 2.80066701698235 2.12546333413447e-11 -1.60082132479507 0.000514379028219012 mirMAP -0.535167589865304 1.15111315539865e-16 NA NA NA hsa-miR-183-5p FAT3 2.08412478942637 1.08931431254487e-10 -1.60082132479507 0.000514379028219012 miRNATAP -0.903040267157081 1.54353833721988e-33 NA NA NA hsa-miR-200a-3p FAT3 2.02394729844446 2.21240501925011e-08 -1.60082132479507 0.000514379028219012 MirTarget;miRNATAP -0.814017262395181 1.22510846731616e-33 NA NA NA hsa-miR-200b-3p FAT3 2.06025765178663 3.07718049337497e-10 -1.60082132479507 0.000514379028219012 MirTarget;TargetScan -0.881557042785804 1.65832699347662e-32 NA NA NA hsa-miR-335-3p FAT3 2.29463721765513 4.1956113745077e-18 -1.60082132479507 0.000514379028219012 MirTarget -0.680988508845797 1.91728726660987e-12 NA NA NA hsa-miR-935 FAT3 2.321600496365 1.00042201726114e-07 -1.60082132479507 0.000514379028219012 PITA;miRNATAP -0.41835522441997 1.24317200393636e-10 NA NA NA hsa-miR-192-5p FAXC 2.0867723747501 3.57854249239079e-08 -1.51914231075936 0.000645899358679245 miRNAWalker2_validate -0.656924778648182 2.39711296148564e-24 NA NA NA hsa-miR-192-5p FBN1 2.0867723747501 3.57854249239079e-08 0.691519482636648 0.00278726958162726 miRNAWalker2_validate -0.179668638948456 5.50319382495199e-07 NA NA NA hsa-miR-146b-5p FBXL17 2.23105707690238 3.83997814011313e-23 -0.585994253234401 1.52454989342516e-08 PITA;miRanda -0.125355760915714 1.4489880431948e-06 NA NA NA hsa-miR-21-5p FBXL17 2.21515015440792 6.0468197386674e-49 -0.585994253234401 1.52454989342516e-08 miRNAWalker2_validate;miRNATAP -0.164003877266903 3.85205643120302e-06 NA NA NA hsa-miR-146b-5p FBXL2 2.23105707690238 3.83997814011313e-23 -0.0416322263648743 0.858599282744402 miRanda -0.30547272374965 8.23153951000487e-08 NA NA NA hsa-miR-200a-3p FBXL2 2.02394729844446 2.21240501925011e-08 -0.0416322263648743 0.858599282744402 MirTarget;miRNATAP -0.285251466167478 4.33040951039633e-15 NA NA NA hsa-miR-21-5p FBXL2 2.21515015440792 6.0468197386674e-49 -0.0416322263648743 0.858599282744402 miRNAWalker2_validate -0.198573361438143 0.0122423354122405 NA NA NA hsa-miR-146b-5p FBXL5 2.23105707690238 3.83997814011313e-23 -0.754793117572575 1.63135809273971e-14 miRanda -0.162792091649594 5.72090604696455e-11 NA NA NA hsa-miR-146b-5p FBXO3 2.23105707690238 3.83997814011313e-23 -0.554476776198341 4.67339274952818e-11 miRanda;miRNATAP -0.180688934336688 4.4252887112089e-19 NA NA NA hsa-miR-21-5p FBXO3 2.21515015440792 6.0468197386674e-49 -0.554476776198341 4.67339274952818e-11 miRNAWalker2_validate -0.194996796654829 6.71063553628614e-12 NA NA NA hsa-miR-335-3p FBXO3 2.29463721765513 4.1956113745077e-18 -0.554476776198341 4.67339274952818e-11 mirMAP -0.115262479853796 2.38235760044683e-10 NA NA NA hsa-miR-146b-5p FBXO30 2.23105707690238 3.83997814011313e-23 -0.260322470127411 0.0645263272243245 miRanda -0.201460614667626 3.73529190116625e-09 NA NA NA hsa-miR-200b-3p FBXO30 2.06025765178663 3.07718049337497e-10 -0.260322470127411 0.0645263272243245 TargetScan -0.23657851130304 1.73939025836622e-24 NA NA NA hsa-miR-141-5p FBXO32 2.13747696823946 1.73124674554872e-11 -0.494938700693123 0.0756149565022972 mirMAP -0.555992868697896 8.3881993530705e-35 NA NA NA hsa-miR-200a-5p FBXO32 2.19152245759943 3.17968183522514e-11 -0.494938700693123 0.0756149565022972 mirMAP -0.520216729227511 2.47288892648456e-32 NA NA NA hsa-miR-335-3p FBXO32 2.29463721765513 4.1956113745077e-18 -0.494938700693123 0.0756149565022972 mirMAP -0.40796975801034 1.90120007855487e-12 NA NA NA hsa-miR-935 FBXO32 2.321600496365 1.00042201726114e-07 -0.494938700693123 0.0756149565022972 mirMAP -0.253552338596481 7.20075253224611e-11 NA NA NA hsa-miR-146b-5p FBXO44 2.23105707690238 3.83997814011313e-23 -0.354524413537848 0.0493588388162105 miRanda -0.154459852892235 0.000565226157959529 NA NA NA hsa-miR-146b-5p FBXO8 2.23105707690238 3.83997814011313e-23 -0.72930231031825 3.20491429160655e-16 miRanda -0.159978058660997 1.29534736956514e-12 NA NA NA hsa-miR-335-3p FBXO9 2.29463721765513 4.1956113745077e-18 -0.599709145592173 4.83657678684425e-10 mirMAP -0.111681140639418 1.04268016207871e-07 NA NA NA hsa-miR-335-3p FBXW7 2.29463721765513 4.1956113745077e-18 -0.418246595636882 2.11537882033504e-05 mirMAP -0.114302036497651 5.2470533745294e-08 NA NA NA hsa-miR-146b-5p FCER1A 2.23105707690238 3.83997814011313e-23 -2.84378819528853 5.74367678274171e-10 miRanda -0.679043107881351 4.0396633576763e-09 NA NA NA hsa-miR-18a-5p FCGR2B 2.04701000113742 1.30593450319289e-12 -0.737827418666758 0.00290394095593152 MirTarget -0.270518242079731 4.40003375639183e-08 NA NA NA hsa-miR-133a-3p FCGR3A -2.63342156915404 5.72661351480585e-12 2.11911588579225 2.96499008387428e-15 MirTarget -0.200439958625751 2.97077875579479e-06 NA NA NA hsa-miR-183-5p FCHSD2 2.08412478942637 1.08931431254487e-10 0.068173820585983 0.54665746300611 MirTarget -0.116220264579779 5.91772694104128e-09 NA NA NA hsa-miR-18a-5p FCHSD2 2.04701000113742 1.30593450319289e-12 0.068173820585983 0.54665746300611 MirTarget;miRNATAP -0.125384265229355 1.72117017015442e-08 NA NA NA hsa-miR-335-3p FCRL2 2.29463721765513 4.1956113745077e-18 -0.264500911577255 0.578950220355594 MirTarget -0.358715746595581 0.0004620807121154 NA NA NA hsa-miR-146b-5p FECH 2.23105707690238 3.83997814011313e-23 -0.430622882642679 0.000293380883803557 miRanda -0.111490934617542 0.000169642686514898 NA NA NA hsa-miR-135b-5p FER 2.80066701698235 2.12546333413447e-11 -0.224587791089798 0.137113603745718 mirMAP -0.140225176317002 5.79733564330884e-11 NA NA NA hsa-miR-146b-5p FER 2.23105707690238 3.83997814011313e-23 -0.224587791089798 0.137113603745718 miRanda;mirMAP -0.142153241545448 0.000140425704567278 NA NA NA hsa-miR-200a-3p FER 2.02394729844446 2.21240501925011e-08 -0.224587791089798 0.137113603745718 mirMAP -0.187928269719934 1.1277062143525e-15 NA NA NA hsa-miR-335-3p FER 2.29463721765513 4.1956113745077e-18 -0.224587791089798 0.137113603745718 mirMAP -0.130312594923363 5.50711157820209e-05 NA NA NA hsa-miR-146b-5p FERMT2 2.23105707690238 3.83997814011313e-23 -0.896574191403877 0.000646206347161597 miRanda -0.462036681344336 3.0007368733875e-13 NA NA NA hsa-miR-200b-3p FERMT2 2.06025765178663 3.07718049337497e-10 -0.896574191403877 0.000646206347161597 TargetScan -0.567914531506366 3.43180257889084e-45 23483548;24064224;26334393 Here we report that Kindlin 2 markedly downregulates the expression of miR-200 family by inducing CpG island hypermethylation; Our data indicate that Kindlin 2 plays a novel role in epigenetic repression of miR-200 family a mechanism that promotes breast cancer invasion;miR 200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin 2; Quantitative mass spectrometry identified 57 putative miR-200b targets including Kindlin-2 previously implicated in the regulation of tumor invasiveness and actin cytoskeleton in other cell types; Enforced expression of miR-200b mimic in ESCC cells led to a decrease of Kindlin-2 expression whereas transfection of miR-200b inhibitor induced Kindlin-2 expression; Furthermore transfection of miR-200b mimic or knockdown of Kindlin-2 in ESCC cells decreased cell protrusion and focal adhesion FA formation reduced cell spreading and invasiveness/migration; Enforced expression of Kindlin-2 largely abrogated the inhibitory effects of miR-200b on ESCC cell invasiveness; The tumor suppressor effects of miR-200b may be due to its suppression of Kindlin-2 a novel target of miR-200b that modulates actin cytoskeleton FA formation and the migratory/invasiveness properties of ESCC;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ;; breast cancer;esophageal cancer;esophageal cancer hsa-miR-21-5p FERMT2 2.21515015440792 6.0468197386674e-49 -0.896574191403877 0.000646206347161597 miRNAWalker2_validate -0.584342697115908 1.79074991263117e-11 NA NA NA hsa-miR-200b-3p FEZ2 2.06025765178663 3.07718049337497e-10 -0.457083662710375 2.71711282591411e-05 TargetScan -0.186801519566876 5.00102004604144e-25 NA NA NA hsa-miR-200b-3p FGD1 2.06025765178663 3.07718049337497e-10 -0.0806606542267625 0.632479567235876 TargetScan -0.251341115318483 7.26883256857235e-19 NA NA NA hsa-miR-146b-3p FGF1 2.08650140817622 5.3293570720033e-22 -0.0632327842797822 0.782087145069923 miRNATAP -0.207068746247816 0.000470150733718735 NA NA NA hsa-miR-18a-5p FGF1 2.04701000113742 1.30593450319289e-12 -0.0632327842797822 0.782087145069923 MirTarget -0.361482447479576 1.16450689829645e-16 NA NA NA hsa-miR-21-5p FGF1 2.21515015440792 6.0468197386674e-49 -0.0632327842797822 0.782087145069923 MirTarget -0.178478383763349 0.0214800108232768 NA NA NA hsa-miR-935 FGF1 2.321600496365 1.00042201726114e-07 -0.0632327842797822 0.782087145069923 MirTarget;miRNATAP -0.117848663753806 0.000315376035823438 NA NA NA hsa-miR-200b-3p FGF10 2.06025765178663 3.07718049337497e-10 -1.8542097387882 2.08993527096072e-05 TargetScan -0.712312310936586 3.76939499928314e-22 NA NA NA hsa-miR-200b-3p FGF12 2.06025765178663 3.07718049337497e-10 -0.170390023502168 0.492844460583921 TargetScan -0.206614309600595 2.72454763868074e-06 NA NA NA hsa-miR-335-3p FGF12 2.29463721765513 4.1956113745077e-18 -0.170390023502168 0.492844460583921 MirTarget -0.185181547582455 0.000520980971873456 NA NA NA hsa-miR-200a-5p FGF13 2.19152245759943 3.17968183522514e-11 -1.30042323380427 5.77730757702532e-05 MirTarget;miRNATAP -0.440239570416363 1.71891567497667e-15 NA NA NA hsa-miR-200b-3p FGF18 2.06025765178663 3.07718049337497e-10 0.577376156575134 0.0408104462212036 TargetScan -0.105225878046072 0.0394084383165484 NA NA NA hsa-miR-192-5p FGF2 2.0867723747501 3.57854249239079e-08 -1.0252152469847 2.26010255795334e-05 miRNAWalker2_validate -0.350526393312018 4.24849619675693e-23 NA NA NA hsa-miR-200b-3p FGF2 2.06025765178663 3.07718049337497e-10 -1.0252152469847 2.26010255795334e-05 mirMAP -0.485657040791614 2.34790149633317e-36 NA NA NA hsa-miR-21-5p FGF2 2.21515015440792 6.0468197386674e-49 -1.0252152469847 2.26010255795334e-05 mirMAP -0.539888539504513 1.99056496184664e-11 NA NA NA hsa-miR-335-3p FGF2 2.29463721765513 4.1956113745077e-18 -1.0252152469847 2.26010255795334e-05 mirMAP -0.402802774005505 1.22243908313238e-15 NA NA NA hsa-miR-335-3p FGF5 2.29463721765513 4.1956113745077e-18 0.549344799655697 0.286593917342756 mirMAP -0.457808914357202 3.35208797374043e-05 NA NA NA hsa-miR-183-5p FGF9 2.08412478942637 1.08931431254487e-10 -0.567473807130705 0.17094770957627 miRNATAP -0.159412935830117 0.035330980163184 NA NA NA hsa-miR-135b-5p FGFR1 2.80066701698235 2.12546333413447e-11 -0.509147194592856 0.0395673749466621 mirMAP -0.244732054611306 2.712797418494e-12 NA NA NA hsa-miR-200a-5p FGFR1 2.19152245759943 3.17968183522514e-11 -0.509147194592856 0.0395673749466621 mirMAP -0.427601362492559 9.35731650238562e-27 NA NA NA hsa-miR-335-3p FGFR1 2.29463721765513 4.1956113745077e-18 -0.509147194592856 0.0395673749466621 mirMAP -0.332726927564988 1.43917473868514e-10 NA NA NA hsa-miR-335-3p FGL2 2.29463721765513 4.1956113745077e-18 -1.6211705931302 2.23551430914503e-08 MirTarget;mirMAP -0.495358535951504 4.51397601742393e-16 NA NA NA hsa-miR-935 FGL2 2.321600496365 1.00042201726114e-07 -1.6211705931302 2.23551430914503e-08 MirTarget -0.278191151103739 1.97904198121117e-11 NA NA NA hsa-miR-146b-5p FHL1 2.23105707690238 3.83997814011313e-23 -2.68723247539724 2.63352126580483e-12 miRanda -0.847548316808503 1.11166651370202e-19 NA NA NA hsa-miR-200b-3p FHL1 2.06025765178663 3.07718049337497e-10 -2.68723247539724 2.63352126580483e-12 MirTarget -0.807765814412638 4.88667547843287e-38 NA NA NA hsa-miR-335-3p FHL1 2.29463721765513 4.1956113745077e-18 -2.68723247539724 2.63352126580483e-12 MirTarget -0.851270408559125 1.88313148018085e-27 NA NA NA hsa-miR-141-5p FHL2 2.13747696823946 1.73124674554872e-11 -0.530367477292089 0.0056856984109164 miRNATAP -0.103800168293862 0.00346605777550951 NA NA NA hsa-miR-146b-5p FHL2 2.23105707690238 3.83997814011313e-23 -0.530367477292089 0.0056856984109164 miRanda;mirMAP -0.139732987231057 0.00358164817814088 NA NA NA hsa-miR-146b-5p FHOD3 2.23105707690238 3.83997814011313e-23 -0.393194914260862 0.12763507806664 miRanda -0.374116000826867 2.37424617780682e-09 NA NA NA hsa-miR-200b-3p FIGN 2.06025765178663 3.07718049337497e-10 -0.904389390868205 0.00585165623379918 MirTarget;TargetScan -0.45791267927381 3.9123474461321e-16 NA NA NA hsa-miR-21-5p FIGN 2.21515015440792 6.0468197386674e-49 -0.904389390868205 0.00585165623379918 miRNAWalker2_validate -0.573656767586535 1.83474714506736e-07 NA NA NA hsa-miR-335-3p FIGN 2.29463721765513 4.1956113745077e-18 -0.904389390868205 0.00585165623379918 mirMAP -0.353589067309239 4.57687779372391e-07 NA NA NA hsa-miR-146b-5p FILIP1 2.23105707690238 3.83997814011313e-23 -0.874271439819252 0.00521696067351959 miRanda -0.514890972850917 1.01128803334755e-11 NA NA NA hsa-miR-21-5p FILIP1L 2.21515015440792 6.0468197386674e-49 -0.175347250548203 0.368391586032627 miRNAWalker2_validate -0.219196634962422 0.000870338603388346 NA NA NA hsa-miR-135b-5p FKBP5 2.80066701698235 2.12546333413447e-11 -0.942251915802888 6.84066806283422e-06 mirMAP -0.249765869762636 2.20050686543032e-17 NA NA NA hsa-miR-146b-5p FKBP5 2.23105707690238 3.83997814011313e-23 -0.942251915802888 6.84066806283422e-06 mirMAP -0.226319667394872 1.64314836197262e-05 NA NA NA hsa-miR-192-5p FKBP5 2.0867723747501 3.57854249239079e-08 -0.942251915802888 6.84066806283422e-06 mirMAP -0.282015376162934 1.41742481509075e-19 NA NA NA hsa-miR-21-5p FKBP5 2.21515015440792 6.0468197386674e-49 -0.942251915802888 6.84066806283422e-06 miRNAWalker2_validate -0.48215813614059 4.34486747683706e-12 NA NA NA hsa-miR-200b-3p FLI1 2.06025765178663 3.07718049337497e-10 -0.29368802380763 0.109052566113421 MirTarget;TargetScan -0.166774150746005 2.61506754735907e-07 NA NA NA hsa-miR-335-3p FLI1 2.29463721765513 4.1956113745077e-18 -0.29368802380763 0.109052566113421 mirMAP -0.2398797950237 4.30291907326224e-10 NA NA NA hsa-miR-146b-5p FLNA 2.23105707690238 3.83997814011313e-23 -0.771411398655463 0.0137692934141899 miRanda -0.512297390386239 1.24282132814965e-11 NA NA NA hsa-miR-196a-5p FLNA 5.05945965885472 4.48343841468539e-25 -0.771411398655463 0.0137692934141899 miRNAWalker2_validate -0.248653215955874 8.32875590787624e-13 NA NA NA hsa-miR-335-3p FLRT2 2.29463721765513 4.1956113745077e-18 -0.0494818009325133 0.866084263577093 mirMAP -0.26353143557593 2.62604420809341e-05 NA NA NA hsa-miR-141-5p FMNL3 2.13747696823946 1.73124674554872e-11 0.554905377810468 4.20747295080031e-05 mirMAP -0.106660148037176 2.02507202676439e-05 NA NA NA hsa-miR-146b-5p FMO2 2.23105707690238 3.83997814011313e-23 -0.967919428681366 0.0198670822156548 miRanda -0.207731597460957 0.0464997947166142 NA NA NA hsa-miR-335-3p FMO2 2.29463721765513 4.1956113745077e-18 -0.967919428681366 0.0198670822156548 mirMAP -0.368783225183438 3.66248699842735e-05 NA NA NA hsa-miR-21-5p FMOD 2.21515015440792 6.0468197386674e-49 -0.295859195523175 0.211723275513595 miRNAWalker2_validate;miRTarBase -0.245217199162045 0.00224506569316894 19906824;23445447 Gain-of miR-21 function in MSMC and LSMC reduced TGF-beta-induced expression of fibromodulin and TGF-beta-induced factor P < 0.05 and moderately altered the rate of cell growth and caspase-3/7 activity in these cells;Our method exhibits ultrahigh sensitivity toward miR-21 with detection limits of 10 fM at 37 °C and 1 aM at 4 °C which corresponds to nine strands of miR-21 in a 15 μL sample and it is capable of distinguishing among miRNA family members ; sarcoma;breast cancer hsa-miR-200b-3p FN1 2.06025765178663 3.07718049337497e-10 1.63571508215028 7.95640379222503e-08 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.370936995941682 7.92466179566393e-12 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-146b-5p FNBP1 2.23105707690238 3.83997814011313e-23 -0.968853731521844 4.0379880862342e-05 miRanda -0.274769452077398 3.01275303669662e-06 NA NA NA hsa-miR-18a-5p FNBP1 2.04701000113742 1.30593450319289e-12 -0.968853731521844 4.0379880862342e-05 miRNATAP -0.451040040129805 2.65308295490691e-24 NA NA NA hsa-miR-192-5p FNBP1 2.0867723747501 3.57854249239079e-08 -0.968853731521844 4.0379880862342e-05 miRNAWalker2_validate -0.366441223667744 3.59795090803688e-27 NA NA NA hsa-miR-21-5p FNBP1 2.21515015440792 6.0468197386674e-49 -0.968853731521844 4.0379880862342e-05 miRNAWalker2_validate -0.491695496704124 4.57520954480045e-10 NA NA NA hsa-miR-335-3p FNBP1 2.29463721765513 4.1956113745077e-18 -0.968853731521844 4.0379880862342e-05 mirMAP -0.451622540567524 4.70340657908854e-21 NA NA NA hsa-miR-146b-5p FNDC5 2.23105707690238 3.83997814011313e-23 -2.19453522201559 3.20426541143299e-10 miRanda -0.71510916088166 3.91952797339484e-17 NA NA NA hsa-miR-335-3p FOS 2.29463721765513 4.1956113745077e-18 -1.53566245560406 5.06686180157846e-09 MirTarget -0.15343229747324 0.00876658532958695 NA NA NA hsa-miR-335-3p FOSB 2.29463721765513 4.1956113745077e-18 -2.06753324015673 8.32248354030433e-08 mirMAP -0.334294193190333 8.17075484282449e-05 NA NA NA hsa-miR-335-3p FOSL2 2.29463721765513 4.1956113745077e-18 -0.670346830289045 7.75279344677276e-07 MirTarget -0.1502729435753 3.00005300075396e-07 NA NA NA hsa-miR-200b-3p FOXF1 2.06025765178663 3.07718049337497e-10 -1.29010168370622 4.15319114357515e-07 MirTarget;TargetScan -0.473534046486302 2.20038709881786e-29 NA NA NA hsa-miR-92a-1-5p FOXF1 2.04820501765632 9.32117486799495e-13 -1.29010168370622 4.15319114357515e-07 MirTarget -0.46662559687792 1.66379284491828e-20 NA NA NA hsa-miR-200b-3p FOXF2 2.06025765178663 3.07718049337497e-10 -1.5540000098613 3.6581898003665e-08 TargetScan -0.482405452685898 6.61937343318697e-24 25798833 The miR 200 family and the miR 183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers; We therefore identified a novel mechanism whereby the miR-200 family and the miR-183~96~182 cluster inhibit lung cancer invasion and metastasis by targeting Foxf2 metastasis lung cancer hsa-miR-146b-5p FOXJ2 2.23105707690238 3.83997814011313e-23 -0.188862041500247 0.0655449504572336 miRanda -0.104826088973023 3.22025901111222e-05 NA NA NA hsa-miR-135b-5p FOXN3 2.80066701698235 2.12546333413447e-11 -0.810742720031483 3.71770789957724e-09 MirTarget -0.202979630632048 3.21382685084718e-27 NA NA NA hsa-miR-141-5p FOXN3 2.13747696823946 1.73124674554872e-11 -0.810742720031483 3.71770789957724e-09 mirMAP -0.271899071024012 9.25972525267862e-32 NA NA NA hsa-miR-200a-3p FOXN3 2.02394729844446 2.21240501925011e-08 -0.810742720031483 3.71770789957724e-09 MirTarget;miRNATAP -0.217524139833834 1.04914581989755e-24 NA NA NA hsa-miR-200b-3p FOXN3 2.06025765178663 3.07718049337497e-10 -0.810742720031483 3.71770789957724e-09 mirMAP -0.229311522260385 1.54538052921149e-22 NA NA NA hsa-miR-21-5p FOXN3 2.21515015440792 6.0468197386674e-49 -0.810742720031483 3.71770789957724e-09 miRNAWalker2_validate;mirMAP -0.370125103011511 3.90391954016989e-16 NA NA NA hsa-miR-335-3p FOXN3 2.29463721765513 4.1956113745077e-18 -0.810742720031483 3.71770789957724e-09 mirMAP -0.256061720172881 3.09830116377114e-19 NA NA NA hsa-miR-194-5p FOXO1 2.24386881692218 9.35116329002209e-11 -0.141393346819543 0.338743641321372 miRNATAP -0.113706209388984 4.03842941304949e-06 24631529 Gα12gep oncogene inhibits FOXO1 in hepatocellular carcinoma as a consequence of miR 135b and miR 194 dysregulation; In addition Gα12QL repressed miR-194 cluster gene products 194/192/215 which contributed to MDM2-mediated FOXO1 repression; Moreover decrease of FOXO1 or miR-194 was statistically significant between stages T1 and T2 whereas increase of miR-135b discriminated tumor stage T3a versus T1/T2 staging liver cancer hsa-miR-183-5p FOXP1 2.08412478942637 1.08931431254487e-10 0.0417845068647216 0.743682787765203 MirTarget;miRNATAP -0.152031913669944 9.82080092437508e-12 NA NA NA hsa-miR-335-3p FOXP1 2.29463721765513 4.1956113745077e-18 0.0417845068647216 0.743682787765203 mirMAP -0.122325282042197 6.5655548854858e-06 NA NA NA hsa-miR-146b-5p FOXP2 2.23105707690238 3.83997814011313e-23 -1.90013232068294 1.16663438786766e-05 mirMAP -0.781266774238588 1.04495013702931e-13 NA NA NA hsa-miR-194-5p FOXP2 2.24386881692218 9.35116329002209e-11 -1.90013232068294 1.16663438786766e-05 miRNATAP -0.632317344270956 1.29849153556126e-19 NA NA NA hsa-miR-196a-5p FOXP2 5.05945965885472 4.48343841468539e-25 -1.90013232068294 1.16663438786766e-05 miRNATAP -0.30361472704541 7.41488379687237e-10 NA NA NA hsa-miR-196b-5p FOXP2 4.51951031652328 7.04026169031626e-18 -1.90013232068294 1.16663438786766e-05 miRNATAP -0.319241050779461 4.31126817173115e-12 NA NA NA hsa-miR-200a-5p FOXP2 2.19152245759943 3.17968183522514e-11 -1.90013232068294 1.16663438786766e-05 mirMAP -0.79495500763237 9.42275003156147e-30 NA NA NA hsa-miR-21-5p FOXP2 2.21515015440792 6.0468197386674e-49 -1.90013232068294 1.16663438786766e-05 mirMAP -0.983149021504648 9.60085642939732e-12 NA NA NA hsa-miR-335-3p FOXP2 2.29463721765513 4.1956113745077e-18 -1.90013232068294 1.16663438786766e-05 mirMAP -0.664598507516291 3.31716139841392e-13 NA NA NA hsa-miR-92a-1-5p FOXP2 2.04820501765632 9.32117486799495e-13 -1.90013232068294 1.16663438786766e-05 MirTarget -0.755105185516707 1.24428873057473e-18 NA NA NA hsa-miR-335-3p FREM1 2.29463721765513 4.1956113745077e-18 -0.818278035160915 0.0678692199357877 mirMAP -0.299335682566987 0.00199311690045116 NA NA NA hsa-miR-21-5p FREM2 2.21515015440792 6.0468197386674e-49 -0.437277584927331 0.463531098169074 mirMAP -0.503870701749596 0.012921161367313 NA NA NA hsa-miR-200b-3p FRMD3 2.06025765178663 3.07718049337497e-10 -1.11045596887577 9.20182612821226e-07 mirMAP -0.174410617596668 2.26124463876951e-05 NA NA NA hsa-miR-21-5p FRMD3 2.21515015440792 6.0468197386674e-49 -1.11045596887577 9.20182612821226e-07 MirTarget -0.337763780848463 1.3321725038746e-05 NA NA NA hsa-miR-335-3p FRMD3 2.29463721765513 4.1956113745077e-18 -1.11045596887577 9.20182612821226e-07 mirMAP -0.210637259561556 2.0036448025617e-05 NA NA NA hsa-miR-18a-5p FRMD4A 2.04701000113742 1.30593450319289e-12 -0.200561131466576 0.154599868425942 miRNATAP -0.214857214512005 1.78273274195682e-15 NA NA NA hsa-miR-200a-3p FRMD4A 2.02394729844446 2.21240501925011e-08 -0.200561131466576 0.154599868425942 MirTarget;miRNATAP -0.226867639038411 1.17224619938771e-27 NA NA NA hsa-miR-200b-3p FRMD4A 2.06025765178663 3.07718049337497e-10 -0.200561131466576 0.154599868425942 MirTarget;TargetScan -0.242420870885251 5.88414112715224e-26 NA NA NA hsa-miR-335-3p FRMD4A 2.29463721765513 4.1956113745077e-18 -0.200561131466576 0.154599868425942 MirTarget;mirMAP -0.168666520695068 1.30331538650425e-08 NA NA NA hsa-miR-146b-5p FRMD6 2.23105707690238 3.83997814011313e-23 -0.439190318770041 0.0686816780837771 MirTarget;miRanda -0.227599485107116 0.000141153049808394 NA NA NA hsa-miR-183-5p FRMD6 2.08412478942637 1.08931431254487e-10 -0.439190318770041 0.0686816780837771 MirTarget;miRNATAP -0.362022712166459 1.65177531535921e-18 NA NA NA hsa-miR-200a-3p FRMD6 2.02394729844446 2.21240501925011e-08 -0.439190318770041 0.0686816780837771 MirTarget;miRNATAP -0.38877906006002 1.77336002924664e-27 NA NA NA hsa-miR-200b-3p FRMD6 2.06025765178663 3.07718049337497e-10 -0.439190318770041 0.0686816780837771 TargetScan -0.408112106522538 9.43180435901221e-25 NA NA NA hsa-miR-335-3p FRMD6 2.29463721765513 4.1956113745077e-18 -0.439190318770041 0.0686816780837771 mirMAP -0.285992653519554 2.07637249425209e-08 NA NA NA hsa-miR-335-3p FRMPD3 2.29463721765513 4.1956113745077e-18 -0.0584119487293197 0.873716622147975 mirMAP -0.365050266327311 3.07442837852709e-06 NA NA NA hsa-miR-146b-5p FRY 2.23105707690238 3.83997814011313e-23 -0.418462380954893 0.0343686444672025 miRanda -0.335370875714058 1.57976990106433e-12 NA NA NA hsa-miR-200a-3p FRY 2.02394729844446 2.21240501925011e-08 -0.418462380954893 0.0343686444672025 miRNATAP -0.206553072054629 4.86525933024433e-11 NA NA NA hsa-miR-335-3p FRZB 2.29463721765513 4.1956113745077e-18 -0.835686001577582 0.00831614897584095 mirMAP -0.43854326395837 4.22159172362222e-11 NA NA NA hsa-miR-146b-5p FSIP2 2.23105707690238 3.83997814011313e-23 -2.25789404680526 1.36417386496454e-08 miRanda -0.393943397817672 0.000100551726469802 NA NA NA hsa-miR-200b-3p FSTL1 2.06025765178663 3.07718049337497e-10 0.589175839273943 0.00382207095964144 MirTarget;TargetScan -0.317264499810708 2.2313760583841e-20 NA NA NA hsa-miR-335-3p FSTL1 2.29463721765513 4.1956113745077e-18 0.589175839273943 0.00382207095964144 mirMAP -0.148483015260817 0.000757179851528401 NA NA NA hsa-miR-146b-3p FSTL4 2.08650140817622 5.3293570720033e-22 -1.60149223346861 0.00196439590981237 miRNATAP -0.453167449066799 0.000823361535326705 NA NA NA hsa-miR-146b-5p FTCD 2.23105707690238 3.83997814011313e-23 -0.881041028295008 0.0415801653523203 miRanda -0.306663741729394 0.00451937990810032 NA NA NA hsa-miR-141-5p FTO 2.13747696823946 1.73124674554872e-11 -0.0277161052593797 0.797735920331275 mirMAP -0.195791510197022 6.74287080495591e-28 NA NA NA hsa-miR-146b-5p FTO 2.23105707690238 3.83997814011313e-23 -0.0277161052593797 0.797735920331275 mirMAP -0.117257738925391 9.39302423210138e-06 NA NA NA hsa-miR-200a-3p FTO 2.02394729844446 2.21240501925011e-08 -0.0277161052593797 0.797735920331275 mirMAP -0.162452484373625 8.92613742194459e-24 NA NA NA hsa-miR-92a-1-5p FTO 2.04820501765632 9.32117486799495e-13 -0.0277161052593797 0.797735920331275 mirMAP -0.111689192206012 3.38994783809883e-07 NA NA NA hsa-miR-200b-3p FUNDC2 2.06025765178663 3.07718049337497e-10 -0.647496532109086 3.79324551686989e-10 mirMAP -0.153259490977747 2.08788304762211e-17 NA NA NA hsa-miR-192-5p FUT11 2.0867723747501 3.57854249239079e-08 0.319728761354113 0.0137711462950643 miRNAWalker2_validate -0.134944868148386 5.99588690601135e-12 NA NA NA hsa-miR-335-3p FUT9 2.29463721765513 4.1956113745077e-18 -2.07207690006486 0.0119796099496288 MirTarget -0.415361018920473 0.0206223858182847 NA NA NA hsa-miR-200a-3p FYCO1 2.02394729844446 2.21240501925011e-08 -0.641344897990956 0.000116510488103172 mirMAP -0.268758960663185 5.43335868328203e-27 NA NA NA hsa-miR-335-3p FYCO1 2.29463721765513 4.1956113745077e-18 -0.641344897990956 0.000116510488103172 mirMAP -0.281279106551391 2.8721694183459e-16 NA NA NA hsa-miR-200b-3p FYN 2.06025765178663 3.07718049337497e-10 -0.13118694976036 0.370511160601143 TargetScan -0.176448438457875 2.99722476456566e-12 NA NA NA hsa-miR-192-5p FZD1 2.0867723747501 3.57854249239079e-08 0.0753981007015279 0.61656364831583 miRNAWalker2_validate -0.137292935739732 2.00935514333215e-09 NA NA NA hsa-miR-200a-5p FZD1 2.19152245759943 3.17968183522514e-11 0.0753981007015279 0.61656364831583 MirTarget -0.126412051792278 1.49326033113079e-06 NA NA NA hsa-miR-146b-5p FZD3 2.23105707690238 3.83997814011313e-23 0.104222443014639 0.603162213805448 MirTarget;miRanda -0.145560341953965 0.00346971755194473 NA NA NA hsa-miR-200a-5p FZD3 2.19152245759943 3.17968183522514e-11 0.104222443014639 0.603162213805448 mirMAP -0.111629383139822 0.00164615682581333 NA NA NA hsa-miR-192-5p FZD4 2.0867723747501 3.57854249239079e-08 -0.113370323882084 0.480936634316706 miRNAWalker2_validate;mirMAP -0.150355937966884 7.50047534617471e-10 NA NA NA hsa-miR-200b-3p FZD4 2.06025765178663 3.07718049337497e-10 -0.113370323882084 0.480936634316706 mirMAP -0.214778042935168 5.17869105722577e-15 NA NA NA hsa-miR-21-5p FZD4 2.21515015440792 6.0468197386674e-49 -0.113370323882084 0.480936634316706 mirMAP -0.160516194106593 0.00316148386387969 NA NA NA hsa-miR-935 FZD4 2.321600496365 1.00042201726114e-07 -0.113370323882084 0.480936634316706 PITA;miRNATAP -0.119590792309579 1.33801812051025e-07 NA NA NA hsa-miR-194-5p FZD6 2.24386881692218 9.35116329002209e-11 0.372408210672117 0.0247362890612118 MirTarget -0.114967495708854 3.82637931799174e-05 NA NA NA hsa-miR-192-5p FZD7 2.0867723747501 3.57854249239079e-08 -0.147011194184077 0.508590593861751 miRNAWalker2_validate -0.211278644102795 3.97283811601885e-10 NA NA NA hsa-miR-335-3p FZD7 2.29463721765513 4.1956113745077e-18 -0.147011194184077 0.508590593861751 mirMAP -0.107946381613777 0.0247434600694844 NA NA NA hsa-miR-192-5p FZD9 2.0867723747501 3.57854249239079e-08 -1.48083323405206 6.68311174752269e-05 miRNATAP -0.117926363474423 0.0464066681748434 NA NA NA hsa-miR-141-5p GAB1 2.13747696823946 1.73124674554872e-11 -0.826054570409834 2.95181484151435e-08 MirTarget -0.233620780640677 8.62197867509189e-19 NA NA NA hsa-miR-18a-5p GAB1 2.04701000113742 1.30593450319289e-12 -0.826054570409834 2.95181484151435e-08 MirTarget;miRNATAP -0.266794758167263 1.7016134105267e-20 NA NA NA hsa-miR-200a-3p GAB1 2.02394729844446 2.21240501925011e-08 -0.826054570409834 2.95181484151435e-08 MirTarget -0.211680765436589 1.37487206154327e-19 NA NA NA hsa-miR-200b-3p GAB1 2.06025765178663 3.07718049337497e-10 -0.826054570409834 2.95181484151435e-08 TargetScan -0.21756089118029 4.92795684674951e-17 NA NA NA hsa-miR-335-3p GAB1 2.29463721765513 4.1956113745077e-18 -0.826054570409834 2.95181484151435e-08 mirMAP -0.156913973257532 1.3941638503494e-06 NA NA NA hsa-miR-200b-3p GABBR2 2.06025765178663 3.07718049337497e-10 -0.605489398613026 0.176960778882388 TargetScan -0.293367220202624 0.000259930719272217 NA NA NA hsa-miR-335-3p GABRB3 2.29463721765513 4.1956113745077e-18 -1.58641301487805 0.0016304247360242 mirMAP -0.480882928795066 9.24288161087522e-06 NA NA NA hsa-miR-935 GABRB3 2.321600496365 1.00042201726114e-07 -1.58641301487805 0.0016304247360242 PITA -0.169895735654447 0.0205263068089456 NA NA NA hsa-miR-146b-5p GALNT11 2.23105707690238 3.83997814011313e-23 -0.275805779012915 0.0124731001990819 miRanda -0.143209457963808 1.08690675434852e-07 NA NA NA hsa-miR-21-5p GALNT12 2.21515015440792 6.0468197386674e-49 -0.936864712433007 1.32317282597544e-06 MirTarget -0.240904144850467 0.00030436018380454 NA NA NA hsa-miR-335-3p GALNT13 2.29463721765513 4.1956113745077e-18 -0.857168264038236 0.0743939574762176 mirMAP -0.274394389275428 0.00836190502774387 NA NA NA hsa-miR-200b-3p GALNT2 2.06025765178663 3.07718049337497e-10 0.0309590514667057 0.777920316536723 MirTarget;TargetScan -0.103719900870136 6.93503217766826e-08 NA NA NA hsa-miR-146b-5p GARNL3 2.23105707690238 3.83997814011313e-23 -0.735004178316896 0.000161943394552572 miRanda -0.323194745367665 8.53158976892025e-12 NA NA NA hsa-miR-183-5p GAS1 2.08412478942637 1.08931431254487e-10 -1.04737668517358 0.0036431226503507 miRNAWalker2_validate -0.579615734152899 2.8571250749175e-21 NA NA NA hsa-miR-146b-3p GAS2 2.08650140817622 5.3293570720033e-22 -0.388236000831504 0.190429393979673 MirTarget;PITA -0.19779672463237 0.0105802336217184 NA NA NA hsa-miR-146b-5p GAS7 2.23105707690238 3.83997814011313e-23 -0.555364342276546 0.0160163588058129 miRNATAP -0.176310018766231 0.00219056919309115 NA NA NA hsa-miR-18a-5p GAS7 2.04701000113742 1.30593450319289e-12 -0.555364342276546 0.0160163588058129 mirMAP -0.383090378018532 2.84434314183946e-18 NA NA NA hsa-miR-194-5p GAS7 2.24386881692218 9.35116329002209e-11 -0.555364342276546 0.0160163588058129 mirMAP -0.345827702789812 1.83234461510658e-21 NA NA NA hsa-miR-196a-5p GAS7 5.05945965885472 4.48343841468539e-25 -0.555364342276546 0.0160163588058129 miRNATAP -0.159448625830836 7.20719665427553e-10 NA NA NA hsa-miR-196b-5p GAS7 4.51951031652328 7.04026169031626e-18 -0.555364342276546 0.0160163588058129 miRNATAP -0.16834934990485 3.32470893062768e-12 NA NA NA hsa-miR-200a-5p GAS7 2.19152245759943 3.17968183522514e-11 -0.555364342276546 0.0160163588058129 mirMAP -0.395121335555903 3.91193059341222e-26 NA NA NA hsa-miR-21-5p GAS7 2.21515015440792 6.0468197386674e-49 -0.555364342276546 0.0160163588058129 mirMAP -0.320393962009667 3.86519044667404e-05 NA NA NA hsa-miR-335-3p GAS7 2.29463721765513 4.1956113745077e-18 -0.555364342276546 0.0160163588058129 mirMAP -0.272058155363145 2.6337746122433e-08 NA NA NA hsa-miR-200b-3p GATA2 2.06025765178663 3.07718049337497e-10 -0.653581887509375 0.00159747550269564 TargetScan -0.158875117069992 1.90016916015782e-05 NA NA NA hsa-miR-135b-5p GCNT2 2.80066701698235 2.12546333413447e-11 -1.54307148477707 1.16223714945299e-10 MirTarget -0.114042656148013 0.00172203109099423 NA NA NA hsa-miR-200b-3p GCNT2 2.06025765178663 3.07718049337497e-10 -1.54307148477707 1.16223714945299e-10 mirMAP -0.162579542509713 0.000256183793989333 NA NA NA hsa-miR-146b-5p GCNT4 2.23105707690238 3.83997814011313e-23 -3.08294452030045 4.77384658036337e-18 miRanda -0.51983716613247 2.17415094451456e-08 NA NA NA hsa-miR-146b-5p GCOM1 2.23105707690238 3.83997814011313e-23 -0.639989479587396 9.64169100286197e-13 miRanda -0.216906744659006 1.88646244248406e-24 NA NA NA hsa-miR-141-5p GDF6 2.13747696823946 1.73124674554872e-11 -0.403736179718871 0.376569127647394 mirMAP -0.601973185892739 7.49196619869391e-14 NA NA NA hsa-miR-200b-3p GDF6 2.06025765178663 3.07718049337497e-10 -0.403736179718871 0.376569127647394 TargetScan -0.58646801391443 8.17644331912555e-14 NA NA NA hsa-miR-135b-5p GDNF 2.80066701698235 2.12546333413447e-11 -1.05986535225821 0.000321077395089479 mirMAP -0.186919232244712 1.54244003977203e-05 NA NA NA hsa-miR-141-5p GDNF 2.13747696823946 1.73124674554872e-11 -1.05986535225821 0.000321077395089479 miRNATAP -0.322810806794022 1.55618633283311e-09 NA NA NA hsa-miR-146b-5p GDNF 2.23105707690238 3.83997814011313e-23 -1.05986535225821 0.000321077395089479 MirTarget;miRNATAP -0.480460686505676 2.00018660585972e-11 NA NA NA hsa-miR-196a-5p GDNF 5.05945965885472 4.48343841468539e-25 -1.05986535225821 0.000321077395089479 MirTarget -0.157460490090622 3.2128965815761e-06 NA NA NA hsa-miR-196b-5p GDNF 4.51951031652328 7.04026169031626e-18 -1.05986535225821 0.000321077395089479 MirTarget -0.15647194315974 8.80714629759631e-07 NA NA NA hsa-miR-200b-3p GDNF 2.06025765178663 3.07718049337497e-10 -1.05986535225821 0.000321077395089479 TargetScan -0.28875177105091 3.69647706920399e-08 NA NA NA hsa-miR-200a-3p GEM 2.02394729844446 2.21240501925011e-08 -0.459200397445968 0.0606575087264476 MirTarget -0.391475331073748 5.68589850290227e-27 NA NA NA hsa-miR-200b-3p GEM 2.06025765178663 3.07718049337497e-10 -0.459200397445968 0.0606575087264476 MirTarget -0.414902315642199 7.50768655555398e-25 NA NA NA hsa-miR-135b-5p GFOD1 2.80066701698235 2.12546333413447e-11 -0.872059806541259 7.04391332347182e-05 mirMAP -0.222513840726004 1.22564887543484e-12 NA NA NA hsa-miR-146b-5p GFOD1 2.23105707690238 3.83997814011313e-23 -0.872059806541259 7.04391332347182e-05 mirMAP -0.353185402264159 4.19856135008687e-11 NA NA NA hsa-miR-21-5p GFOD1 2.21515015440792 6.0468197386674e-49 -0.872059806541259 7.04391332347182e-05 mirMAP -0.461805511091924 2.78504022174439e-10 NA NA NA hsa-miR-935 GFPT2 2.321600496365 1.00042201726114e-07 0.188215212244002 0.508138108826782 MirTarget;PITA;miRNATAP -0.117985421849811 0.00393160704755782 NA NA NA hsa-miR-135b-5p GFRA1 2.80066701698235 2.12546333413447e-11 -3.06995033064001 6.5107128166333e-10 mirMAP -0.596584639176284 5.56347387124164e-17 NA NA NA hsa-miR-200a-3p GFRA1 2.02394729844446 2.21240501925011e-08 -3.06995033064001 6.5107128166333e-10 mirMAP -0.647647771699957 5.27851182603364e-16 NA NA NA hsa-miR-200a-5p GFRA1 2.19152245759943 3.17968183522514e-11 -3.06995033064001 6.5107128166333e-10 mirMAP -0.717493364523485 9.53429129447217e-17 NA NA NA hsa-miR-200b-3p GFRA1 2.06025765178663 3.07718049337497e-10 -3.06995033064001 6.5107128166333e-10 mirMAP -0.706153014797647 8.77709464905749e-16 NA NA NA hsa-miR-335-3p GFRA1 2.29463721765513 4.1956113745077e-18 -3.06995033064001 6.5107128166333e-10 mirMAP -0.897555384374103 8.88936337410516e-18 NA NA NA hsa-miR-200a-3p GFRA2 2.02394729844446 2.21240501925011e-08 -2.58628382037502 1.9202934668223e-14 mirMAP -0.504609266087653 1.50983577969022e-20 NA NA NA hsa-miR-935 GGT7 2.321600496365 1.00042201726114e-07 -0.440918109324323 0.0640187257015633 miRNATAP -0.125452065273054 0.000240642522835459 NA NA NA hsa-miR-200a-3p GIT2 2.02394729844446 2.21240501925011e-08 -0.019873435999501 0.826579600264393 MirTarget -0.12618494950302 3.66159900401813e-20 NA NA NA hsa-miR-200b-3p GIT2 2.06025765178663 3.07718049337497e-10 -0.019873435999501 0.826579600264393 MirTarget;TargetScan -0.133671276224237 1.12907684895426e-18 NA NA NA hsa-miR-935 GJA1 2.321600496365 1.00042201726114e-07 -0.485265789933759 0.0217924391244713 PITA;miRNATAP -0.140219183777546 3.3523065163481e-06 NA NA NA hsa-miR-135b-5p GJC1 2.80066701698235 2.12546333413447e-11 -0.0478963839809916 0.854609133332298 mirMAP -0.232373562411873 4.10545151843283e-10 NA NA NA hsa-miR-146b-5p GJC1 2.23105707690238 3.83997814011313e-23 -0.0478963839809916 0.854609133332298 miRanda -0.343985004497145 6.71596000066604e-08 NA NA NA hsa-miR-200a-3p GJC1 2.02394729844446 2.21240501925011e-08 -0.0478963839809916 0.854609133332298 MirTarget;miRNATAP -0.437743523887651 2.3246982801556e-30 NA NA NA hsa-miR-200b-3p GJC1 2.06025765178663 3.07718049337497e-10 -0.0478963839809916 0.854609133332298 MirTarget;TargetScan -0.470894342889208 6.68888824817788e-29 NA NA NA hsa-miR-335-3p GKN2 2.29463721765513 4.1956113745077e-18 -7.62192913471862 1.03200009599373e-13 mirMAP -1.15879990578998 4.1687509739222e-07 NA NA NA hsa-miR-192-5p GLCCI1 2.0867723747501 3.57854249239079e-08 -0.998098561450464 3.66984761021317e-10 miRNAWalker2_validate -0.11734661026095 4.08880821541927e-06 NA NA NA hsa-miR-194-5p GLCCI1 2.24386881692218 9.35116329002209e-11 -0.998098561450464 3.66984761021317e-10 MirTarget -0.121786271290972 1.03107884536391e-05 NA NA NA hsa-miR-200a-3p GLCCI1 2.02394729844446 2.21240501925011e-08 -0.998098561450464 3.66984761021317e-10 MirTarget;miRNATAP -0.125588951995795 2.38898784616856e-06 NA NA NA hsa-miR-200b-3p GLCCI1 2.06025765178663 3.07718049337497e-10 -0.998098561450464 3.66984761021317e-10 TargetScan -0.149555287960042 2.78684513474327e-07 NA NA NA hsa-miR-21-5p GLCCI1 2.21515015440792 6.0468197386674e-49 -0.998098561450464 3.66984761021317e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.298469768405141 4.96385683552513e-08 NA NA NA hsa-miR-335-3p GLCCI1 2.29463721765513 4.1956113745077e-18 -0.998098561450464 3.66984761021317e-10 mirMAP -0.213022810921855 7.15388225501721e-10 NA NA NA hsa-miR-146b-5p GLDN 2.23105707690238 3.83997814011313e-23 -0.516066615600536 0.100608661001978 miRanda -0.282216095665602 0.000296958404835395 NA NA NA hsa-miR-200a-3p GLDN 2.02394729844446 2.21240501925011e-08 -0.516066615600536 0.100608661001978 MirTarget -0.313122531152316 4.0581730839505e-10 NA NA NA hsa-miR-200a-5p GLDN 2.19152245759943 3.17968183522514e-11 -0.516066615600536 0.100608661001978 mirMAP -0.348008577431137 1.32536733663552e-10 NA NA NA hsa-miR-200a-3p GLI2 2.02394729844446 2.21240501925011e-08 0.731181683362132 0.00219283809760324 MirTarget -0.266382994693993 2.08251297927292e-12 NA NA NA hsa-miR-200b-3p GLI3 2.06025765178663 3.07718049337497e-10 -0.615147701555008 0.0148224102483965 TargetScan -0.483957405916442 3.07747114087143e-33 NA NA NA hsa-miR-335-3p GLIPR1 2.29463721765513 4.1956113745077e-18 0.14644240393988 0.327601793541315 mirMAP -0.155053464795792 1.02286742625977e-06 NA NA NA hsa-miR-335-3p GLIPR1L2 2.29463721765513 4.1956113745077e-18 -1.14115206831728 1.3908631530874e-05 mirMAP -0.412898582256455 6.64355542193053e-14 NA NA NA hsa-miR-18a-5p GLIS2 2.04701000113742 1.30593450319289e-12 0.760680870507226 0.000261285188401114 mirMAP -0.194325982341656 3.80831001880107e-06 NA NA NA hsa-miR-200b-3p GLIS2 2.06025765178663 3.07718049337497e-10 0.760680870507226 0.000261285188401114 TargetScan -0.25865500905463 1.18313250230419e-12 NA NA NA hsa-miR-146b-5p GLP1R 2.23105707690238 3.83997814011313e-23 -1.56342150180017 0.00228550171529839 miRanda -0.609343688798718 1.55884000934601e-06 NA NA NA hsa-miR-135b-5p GLRB 2.80066701698235 2.12546333413447e-11 -1.01651058047285 0.000737289365771539 MirTarget -0.299998449576295 2.75109798301364e-12 NA NA NA hsa-miR-18a-5p GLRB 2.04701000113742 1.30593450319289e-12 -1.01651058047285 0.000737289365771539 MirTarget;miRNATAP -0.520320725310423 1.26751787807212e-19 NA NA NA hsa-miR-935 GLRB 2.321600496365 1.00042201726114e-07 -1.01651058047285 0.000737289365771539 MirTarget -0.278700720926143 4.75769047495272e-11 NA NA NA hsa-miR-183-5p GLUL 2.08412478942637 1.08931431254487e-10 -1.1030137811041 1.43199220105315e-12 miRNAWalker2_validate;MirTarget -0.1248875366555 2.054847139668e-05 NA NA NA hsa-miR-196a-5p GLUL 5.05945965885472 4.48343841468539e-25 -1.1030137811041 1.43199220105315e-12 miRNAWalker2_validate -0.12315756070285 8.85455349450465e-12 NA NA NA hsa-miR-200a-5p GLUL 2.19152245759943 3.17968183522514e-11 -1.1030137811041 1.43199220105315e-12 MirTarget -0.126243707246003 9.97805429098439e-06 NA NA NA hsa-miR-21-5p GLYR1 2.21515015440792 6.0468197386674e-49 -0.386895735470327 2.82825357591908e-06 miRNATAP -0.206353691058175 2.1736589789474e-14 NA NA NA hsa-miR-935 GNAL 2.321600496365 1.00042201726114e-07 -1.05101187353865 0.000317291051700254 mirMAP -0.335898177927481 5.64972095195923e-17 NA NA NA hsa-miR-146b-5p GNAO1 2.23105707690238 3.83997814011313e-23 -1.85268367495665 6.00392357820662e-06 mirMAP -0.726289235719042 2.93392125196199e-13 NA NA NA hsa-miR-21-5p GNAQ 2.21515015440792 6.0468197386674e-49 -0.366797789436988 0.0010245125465966 miRNAWalker2_validate -0.156080037034321 3.50915664444775e-05 NA NA NA hsa-miR-335-3p GNAQ 2.29463721765513 4.1956113745077e-18 -0.366797789436988 0.0010245125465966 mirMAP -0.103777846391489 1.49206887809495e-05 NA NA NA hsa-miR-21-5p GNG2 2.21515015440792 6.0468197386674e-49 -0.605529121736312 0.000949342195392306 miRNATAP -0.259278564741831 2.95980793440514e-05 NA NA NA hsa-miR-335-3p GNG2 2.29463721765513 4.1956113745077e-18 -0.605529121736312 0.000949342195392306 mirMAP -0.267796828879394 2.96397917838353e-12 NA NA NA hsa-miR-200a-3p GNG4 2.02394729844446 2.21240501925011e-08 -1.60072042333973 0.000794767384488091 mirMAP -0.315859887550457 5.53226520275043e-05 NA NA NA hsa-miR-200b-3p GNG4 2.06025765178663 3.07718049337497e-10 -1.60072042333973 0.000794767384488091 mirMAP -0.327667595207164 0.000142490431587038 NA NA NA hsa-miR-18a-5p GNG7 2.04701000113742 1.30593450319289e-12 -2.55105842667086 9.83062399389685e-21 mirMAP -0.568427533556065 1.83281841195959e-25 NA NA NA hsa-miR-200a-3p GNG7 2.02394729844446 2.21240501925011e-08 -2.55105842667086 9.83062399389685e-21 MirTarget;miRNATAP -0.422442619699771 5.83703169220002e-21 NA NA NA hsa-miR-146b-5p GNPDA2 2.23105707690238 3.83997814011313e-23 -0.296025439799698 0.0247934639005846 miRanda -0.151580299591454 2.9397747133888e-06 NA NA NA hsa-miR-18a-5p GNPDA2 2.04701000113742 1.30593450319289e-12 -0.296025439799698 0.0247934639005846 MirTarget -0.12941027185473 8.39939370519517e-07 NA NA NA hsa-miR-192-5p GPC4 2.0867723747501 3.57854249239079e-08 -0.188149462544121 0.37722256005152 miRNAWalker2_validate -0.112746845788055 0.000687905252262054 NA NA NA hsa-miR-200b-3p GPC6 2.06025765178663 3.07718049337497e-10 -0.0536777685148131 0.814647314570525 TargetScan -0.284128771755665 5.9863355336262e-13 NA NA NA hsa-miR-21-5p GPD1L 2.21515015440792 6.0468197386674e-49 -1.07269581488453 9.10955853600853e-14 miRNAWalker2_validate -0.330360811923411 2.49582359901436e-11 NA NA NA hsa-miR-335-3p GPD1L 2.29463721765513 4.1956113745077e-18 -1.07269581488453 9.10955853600853e-14 mirMAP -0.129460317677009 6.29160187521384e-05 NA NA NA hsa-miR-146b-5p GPM6A 2.23105707690238 3.83997814011313e-23 -3.49353111581557 4.10952936768988e-11 miRanda -0.974244064239407 1.16508265940116e-13 NA NA NA hsa-miR-200b-3p GPM6A 2.06025765178663 3.07718049337497e-10 -3.49353111581557 4.10952936768988e-11 TargetScan -0.985236304175053 2.6592698819066e-28 NA NA NA hsa-miR-935 GPM6A 2.321600496365 1.00042201726114e-07 -3.49353111581557 4.10952936768988e-11 PITA -0.650814538617657 2.34120592764049e-18 NA NA NA hsa-miR-135b-5p GPM6B 2.80066701698235 2.12546333413447e-11 -2.1566086132752 4.65701200932464e-14 MirTarget -0.395542166765005 3.13712532957135e-22 NA NA NA hsa-miR-146b-5p GPM6B 2.23105707690238 3.83997814011313e-23 -2.1566086132752 4.65701200932464e-14 miRanda -0.661309212012318 1.76978217062204e-21 NA NA NA hsa-miR-194-5p GPM6B 2.24386881692218 9.35116329002209e-11 -2.1566086132752 4.65701200932464e-14 miRNATAP -0.560653037969764 2.64534114274346e-36 NA NA NA hsa-miR-200a-3p GPM6B 2.02394729844446 2.21240501925011e-08 -2.1566086132752 4.65701200932464e-14 miRNATAP -0.510476123900947 3.5361414365805e-31 NA NA NA hsa-miR-335-3p GPR135 2.29463721765513 4.1956113745077e-18 -0.462687958521296 0.0386774597991798 mirMAP -0.234929750727763 8.32870190409789e-07 NA NA NA hsa-miR-200b-3p GPR146 2.06025765178663 3.07718049337497e-10 -1.05300131983879 3.19301406494563e-09 TargetScan -0.250477521044042 1.1881177826671e-15 NA NA NA hsa-miR-183-5p GPR153 2.08412478942637 1.08931431254487e-10 -0.139533614460711 0.514523373271394 mirMAP -0.118204286174876 0.00234338994766105 NA NA NA hsa-miR-135b-5p GPR155 2.80066701698235 2.12546333413447e-11 -1.88699759781493 1.49950892955009e-12 MirTarget -0.281648757244155 7.710432889495e-13 NA NA NA hsa-miR-335-3p GPR155 2.29463721765513 4.1956113745077e-18 -1.88699759781493 1.49950892955009e-12 MirTarget;mirMAP -0.484188378077813 1.39007324558569e-17 NA NA NA hsa-miR-935 GPR155 2.321600496365 1.00042201726114e-07 -1.88699759781493 1.49950892955009e-12 PITA -0.26696764756539 5.48849201649924e-12 NA NA NA hsa-miR-196a-5p GPR156 5.05945965885472 4.48343841468539e-25 -0.690755543314642 0.0669042806502305 miRNATAP -0.104824197576696 0.0160687493956311 NA NA NA hsa-miR-335-3p GPR171 2.29463721765513 4.1956113745077e-18 -0.128498776255599 0.623373565795824 MirTarget -0.146607198738778 0.00944588392248376 NA NA NA hsa-miR-192-5p GPR173 2.0867723747501 3.57854249239079e-08 0.236285832262454 0.300156414322761 mirMAP -0.187728561330626 8.1248684874819e-08 NA NA NA hsa-miR-200b-3p GPR173 2.06025765178663 3.07718049337497e-10 0.236285832262454 0.300156414322761 TargetScan -0.273168494059699 4.56002141384954e-12 NA NA NA hsa-miR-335-3p GPR173 2.29463721765513 4.1956113745077e-18 0.236285832262454 0.300156414322761 mirMAP -0.131996772085293 0.00733602244119166 NA NA NA hsa-miR-200b-3p GPR27 2.06025765178663 3.07718049337497e-10 -2.46222755352119 1.09764076702222e-07 TargetScan -0.567286902763872 6.06655129301196e-12 NA NA NA hsa-miR-192-5p GPR37 2.0867723747501 3.57854249239079e-08 -0.784678241835113 0.0673137411875174 miRNAWalker2_validate -0.346935605328656 1.52981941393634e-07 NA NA NA hsa-miR-146b-5p GPR37L1 2.23105707690238 3.83997814011313e-23 -0.0683061577093471 0.795457505833897 miRanda -0.265754805798678 4.32762321347661e-05 NA NA NA hsa-miR-196a-5p GPRASP1 5.05945965885472 4.48343841468539e-25 -1.12400005112558 0.000125745093101333 MirTarget -0.230339351787079 2.34235123774268e-12 NA NA NA hsa-miR-196b-5p GPRASP1 4.51951031652328 7.04026169031626e-18 -1.12400005112558 0.000125745093101333 MirTarget -0.275421581544977 4.44785665009836e-20 NA NA NA hsa-miR-146b-3p GPSM1 2.08650140817622 5.3293570720033e-22 -0.152453056692354 0.480207276756973 miRNATAP -0.146661003595165 0.0091041349971738 NA NA NA hsa-miR-146b-5p GPX3 2.23105707690238 3.83997814011313e-23 -2.75245597948977 1.45923787640153e-24 miRanda -0.502427336272004 1.25659343316863e-12 NA NA NA hsa-miR-183-5p GREB1L 2.08412478942637 1.08931431254487e-10 -1.18599359346287 0.00788624523854754 mirMAP -0.425633554399498 1.1007086572579e-07 NA NA NA hsa-miR-200b-3p GREB1L 2.06025765178663 3.07718049337497e-10 -1.18599359346287 0.00788624523854754 TargetScan -0.337968708941261 2.39826490351051e-05 NA NA NA hsa-miR-200b-3p GREM1 2.06025765178663 3.07718049337497e-10 0.90187683465825 0.0169113574597225 MirTarget -0.480031589815113 2.03933118805624e-13 NA NA NA hsa-miR-183-5p GREM2 2.08412478942637 1.08931431254487e-10 -2.41694634218495 9.57530301376063e-07 miRNATAP -0.84550071965019 1.03949374618865e-23 NA NA NA hsa-miR-200b-3p GREM2 2.06025765178663 3.07718049337497e-10 -2.41694634218495 9.57530301376063e-07 TargetScan -0.650966983729518 5.83407823607555e-14 NA NA NA hsa-miR-146b-5p GRIA1 2.23105707690238 3.83997814011313e-23 -1.86501656904484 6.94746142617262e-05 miRanda -0.633816141657009 4.65896994065759e-08 NA NA NA hsa-miR-192-5p GRIA1 2.0867723747501 3.57854249239079e-08 -1.86501656904484 6.94746142617262e-05 miRNAWalker2_validate -0.459791959098861 1.94392775067077e-10 NA NA NA hsa-miR-335-3p GRIA1 2.29463721765513 4.1956113745077e-18 -1.86501656904484 6.94746142617262e-05 mirMAP -0.621214989151987 4.68346760827027e-10 NA NA NA hsa-miR-135b-5p GRIA3 2.80066701698235 2.12546333413447e-11 -1.95604419496649 1.21363305778361e-09 MirTarget -0.333842088865811 1.08274616085125e-12 NA NA NA hsa-miR-146b-5p GRIA3 2.23105707690238 3.83997814011313e-23 -1.95604419496649 1.21363305778361e-09 MirTarget;PITA;miRanda;miRNATAP -0.503323539438687 3.99503676254606e-10 NA NA NA hsa-miR-335-3p GRIA4 2.29463721765513 4.1956113745077e-18 -3.34079334476369 5.30722962007673e-17 mirMAP -0.581263808178293 5.95166670107189e-11 NA NA NA hsa-miR-146b-5p GRID1 2.23105707690238 3.83997814011313e-23 -0.674224609518614 0.0181569595405917 PITA;miRanda;miRNATAP -0.480372341086443 2.65405601314924e-12 NA NA NA hsa-miR-146b-5p GRIK1 2.23105707690238 3.83997814011313e-23 -1.67227177697305 9.28279100278976e-10 miRanda -0.328779538394593 2.17101729503544e-06 NA NA NA hsa-miR-335-3p GRIK2 2.29463721765513 4.1956113745077e-18 -1.41122461820468 0.000128621472303281 mirMAP -0.340054785952803 2.04289812022079e-05 NA NA NA hsa-miR-141-5p GRIK3 2.13747696823946 1.73124674554872e-11 -3.20826222342764 3.18922605914462e-10 mirMAP -0.842920735219481 1.48959773100498e-20 NA NA NA hsa-miR-194-5p GRIK3 2.24386881692218 9.35116329002209e-11 -3.20826222342764 3.18922605914462e-10 mirMAP -0.593856617947383 6.32030015341485e-12 NA NA NA hsa-miR-200a-3p GRIK3 2.02394729844446 2.21240501925011e-08 -3.20826222342764 3.18922605914462e-10 mirMAP -0.730670126690203 1.80367300690456e-19 NA NA NA hsa-miR-21-5p GRIK3 2.21515015440792 6.0468197386674e-49 -3.20826222342764 3.18922605914462e-10 mirMAP -1.59055817668351 1.01051233383076e-21 NA NA NA hsa-miR-335-3p GRIK3 2.29463721765513 4.1956113745077e-18 -3.20826222342764 3.18922605914462e-10 mirMAP -0.816351268599343 7.64741454385189e-14 NA NA NA hsa-miR-92a-1-5p GRIK3 2.04820501765632 9.32117486799495e-13 -3.20826222342764 3.18922605914462e-10 mirMAP -0.690216730282628 8.01080336675939e-11 NA NA NA hsa-miR-935 GRIK3 2.321600496365 1.00042201726114e-07 -3.20826222342764 3.18922605914462e-10 miRNATAP -0.609356639501987 2.08411494253975e-17 NA NA NA hsa-miR-200b-3p GRIN2A 2.06025765178663 3.07718049337497e-10 -2.16084479164215 3.33003121849154e-06 TargetScan -0.663279344356061 1.94774443346422e-16 NA NA NA hsa-miR-335-3p GRIN2A 2.29463721765513 4.1956113745077e-18 -2.16084479164215 3.33003121849154e-06 mirMAP -0.75793437518788 7.26723998883551e-15 NA NA NA hsa-miR-200b-3p GRIP1 2.06025765178663 3.07718049337497e-10 -0.818995365925745 0.00110036000308407 TargetScan -0.252718589497295 1.34686591638647e-08 NA NA NA hsa-miR-200a-3p GSN 2.02394729844446 2.21240501925011e-08 -1.67193485449861 1.45686176833727e-18 MirTarget -0.327152605651441 2.46580062940569e-27 NA NA NA hsa-miR-335-3p GSTM3 2.29463721765513 4.1956113745077e-18 -1.18735339615742 3.15391774238042e-05 mirMAP -0.179916544686912 0.00399314348670832 NA NA NA hsa-miR-146b-5p GTF2IP1 2.23105707690238 3.83997814011313e-23 -0.216313722584019 0.0539258580009689 miRanda -0.155160476373817 1.22995620207602e-08 NA NA NA hsa-miR-146b-5p GTF2IRD2 2.23105707690238 3.83997814011313e-23 -0.850195735810771 4.96430236731119e-05 miRanda -0.352118416517839 4.8545444053954e-12 NA NA NA hsa-miR-146b-5p GTF2IRD2B 2.23105707690238 3.83997814011313e-23 -0.530815783299768 0.00358800324618294 miRanda -0.266676616602002 1.98521363590533e-09 NA NA NA hsa-miR-200b-3p GUCY1A3 2.06025765178663 3.07718049337497e-10 0.320384598483079 0.245679823414486 TargetScan -0.452328098297678 4.10073589854362e-23 NA NA NA hsa-miR-135b-5p GULP1 2.80066701698235 2.12546333413447e-11 -0.781307951969337 0.00107208390718881 MirTarget -0.118797088075431 0.000742429517270142 NA NA NA hsa-miR-192-5p GULP1 2.0867723747501 3.57854249239079e-08 -0.781307951969337 0.00107208390718881 miRNAWalker2_validate -0.118533013079387 0.00164543105330443 NA NA NA hsa-miR-335-3p GULP1 2.29463721765513 4.1956113745077e-18 -0.781307951969337 0.00107208390718881 MirTarget;mirMAP -0.264567531187711 2.23469013193525e-07 NA NA NA hsa-miR-194-5p GYG1 2.24386881692218 9.35116329002209e-11 -0.445505811108426 0.000513821054464544 MirTarget;miRNATAP -0.219149074403694 8.74472244386503e-29 NA NA NA hsa-miR-18a-5p H6PD 2.04701000113742 1.30593450319289e-12 0.259516322986162 0.0394780541413495 mirMAP -0.146023303672607 4.11748575373629e-09 NA NA NA hsa-miR-146b-5p HADHB 2.23105707690238 3.83997814011313e-23 -0.846249738328805 1.34285603921348e-21 miRanda -0.120913660457231 2.34532509087089e-07 NA NA NA hsa-miR-146b-3p HAND2 2.08650140817622 5.3293570720033e-22 -1.73988835783795 0.00390292210690987 PITA -0.63903182655369 4.64798821272302e-05 NA NA NA hsa-miR-146b-3p HAP1 2.08650140817622 5.3293570720033e-22 -1.12119015316677 0.00237081107452073 PITA -0.318184322643278 0.000985830416817402 NA NA NA hsa-miR-200b-3p HAS2 2.06025765178663 3.07718049337497e-10 0.0573496916277678 0.788936564855642 TargetScan -0.104649390180562 0.00653562765195696 NA NA NA hsa-miR-146b-5p HBP1 2.23105707690238 3.83997814011313e-23 -0.454367094530242 9.57166882993669e-09 miRanda -0.126045065581568 9.75087516929871e-11 NA NA NA hsa-miR-21-5p HBP1 2.21515015440792 6.0468197386674e-49 -0.454367094530242 9.57166882993669e-09 miRNATAP -0.180193775896356 9.109182580307e-12 26282675 MicroRNA 21 is a potential link between non alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1 p53 Srebp1c pathway; Further studies revealed that Hbp1 was a novel target of microRNA-21 and a transcriptional activator of p53 liver cancer hsa-miR-146b-5p HCFC2 2.23105707690238 3.83997814011313e-23 -0.716945650565211 4.70460742079511e-08 miRanda -0.22366273264987 3.9449286030545e-12 NA NA NA hsa-miR-200a-5p HCFC2 2.19152245759943 3.17968183522514e-11 -0.716945650565211 4.70460742079511e-08 MirTarget;miRNATAP -0.232077447960932 7.57020840669754e-27 NA NA NA hsa-miR-200b-3p HCFC2 2.06025765178663 3.07718049337497e-10 -0.716945650565211 4.70460742079511e-08 TargetScan -0.224622967909466 3.67656896848055e-24 NA NA NA hsa-miR-935 HCFC2 2.321600496365 1.00042201726114e-07 -0.716945650565211 4.70460742079511e-08 MirTarget;PITA;miRNATAP -0.127179718741681 9.67455586249952e-12 NA NA NA hsa-miR-18a-5p HCN4 2.04701000113742 1.30593450319289e-12 -1.896789437141 0.000161609503152117 miRNATAP -0.258405317680251 0.0122388708429725 NA NA NA hsa-miR-141-5p HDAC4 2.13747696823946 1.73124674554872e-11 -0.328802223196003 0.0475619343153322 miRNATAP -0.271586450643457 9.31065116152099e-22 NA NA NA hsa-miR-200a-3p HDAC4 2.02394729844446 2.21240501925011e-08 -0.328802223196003 0.0475619343153322 miRNATAP -0.23068003976545 1.05425349872021e-19 21837748 Furthermore our results suggested that the histone deacetylase 4 HDAC4 inhibited the expression of miR-200a and its promoter activity and reduced the histone H3 acetylation level at the mir-200a promoter through a Sp1-dependent pathway; Interestingly we observed that the miR-200a directly targeted the 3'-untranslated region of the HDAC4 messenger RNA and repressed expression of HDAC4; Through targeting HDAC4 miR-200a also induced the up-regulation of total acetyl-histone H3 levels and increased the histone H3 acetylation level at the p21WAF/Cip1 promoter; Our findings suggest that the HDAC4/Sp1/miR-200a regulatory network induces the down-regulation of miR-200a and the up-regulation of HDAC4 in HCC liver cancer hsa-miR-200b-3p HDAC4 2.06025765178663 3.07718049337497e-10 -0.328802223196003 0.0475619343153322 TargetScan -0.240059007124108 1.38953567168753e-17 NA NA NA hsa-miR-335-3p HDAC4 2.29463721765513 4.1956113745077e-18 -0.328802223196003 0.0475619343153322 mirMAP -0.150158583734911 2.36122747951738e-05 NA NA NA hsa-miR-196a-5p HDAC9 5.05945965885472 4.48343841468539e-25 -0.754703190014935 0.00494911298787502 miRNATAP -0.160937300054833 1.31051154277789e-07 NA NA NA hsa-miR-196b-5p HDAC9 4.51951031652328 7.04026169031626e-18 -0.754703190014935 0.00494911298787502 miRNATAP -0.167839306872695 4.35827660644261e-09 NA NA NA hsa-miR-146b-3p HDHD2 2.08650140817622 5.3293570720033e-22 -0.529599752720316 4.07738350800224e-08 PITA;miRNATAP -0.1267833421414 5.11722515158939e-07 NA NA NA hsa-miR-146b-5p HDX 2.23105707690238 3.83997814011313e-23 -0.790100243041593 0.000344401760430977 miRanda -0.277406767384832 3.77645721688195e-07 NA NA NA hsa-miR-196a-5p HDX 5.05945965885472 4.48343841468539e-25 -0.790100243041593 0.000344401760430977 MirTarget;miRNATAP -0.151654643444254 1.23058500995636e-09 NA NA NA hsa-miR-196b-5p HDX 4.51951031652328 7.04026169031626e-18 -0.790100243041593 0.000344401760430977 MirTarget;miRNATAP -0.172764249050341 8.26206414593114e-14 NA NA NA hsa-miR-335-3p HDX 2.29463721765513 4.1956113745077e-18 -0.790100243041593 0.000344401760430977 MirTarget -0.383757710033444 2.7694967020905e-17 NA NA NA hsa-miR-146b-5p HECTD2 2.23105707690238 3.83997814011313e-23 -0.215569022714971 0.25466848684357 miRanda -0.207982041368963 7.8724396884378e-06 NA NA NA hsa-miR-183-5p HECTD2 2.08412478942637 1.08931431254487e-10 -0.215569022714971 0.25466848684357 miRNATAP -0.311309305490817 9.37605422841175e-23 NA NA NA hsa-miR-200b-3p HEG1 2.06025765178663 3.07718049337497e-10 0.241718758295208 0.17358962483006 TargetScan -0.26245029771979 1.88067331361102e-18 NA NA NA hsa-miR-335-3p HEG1 2.29463721765513 4.1956113745077e-18 0.241718758295208 0.17358962483006 mirMAP -0.183594345008508 1.15357611704109e-06 NA NA NA hsa-miR-200a-5p HEPH 2.19152245759943 3.17968183522514e-11 0.228231285132078 0.443602776319354 mirMAP -0.122719811563062 0.0205721683944542 NA NA NA hsa-miR-146b-5p HERC1 2.23105707690238 3.83997814011313e-23 -0.195905781077467 0.0854376565297647 miRanda -0.109829714707927 9.18463622288033e-05 NA NA NA hsa-miR-18a-5p HERC1 2.04701000113742 1.30593450319289e-12 -0.195905781077467 0.0854376565297647 miRNAWalker2_validate -0.151540216505898 7.70850363060374e-12 NA NA NA hsa-miR-146b-5p HEY2 2.23105707690238 3.83997814011313e-23 -0.0318286615433385 0.852203209203717 PITA;miRanda -0.109638694607382 0.00984687541786053 NA NA NA hsa-miR-935 HEY2 2.321600496365 1.00042201726114e-07 -0.0318286615433385 0.852203209203717 PITA -0.10155510822175 2.96414993278014e-05 NA NA NA hsa-miR-200a-3p HEYL 2.02394729844446 2.21240501925011e-08 1.41410265722299 2.7585141533517e-09 mirMAP -0.206232730989393 1.76497116273116e-07 NA NA NA hsa-miR-200a-3p HGF 2.02394729844446 2.21240501925011e-08 0.300300239635918 0.22287526354436 MirTarget -0.18068176483526 5.88659287877734e-06 NA NA NA hsa-miR-335-3p HGF 2.29463721765513 4.1956113745077e-18 0.300300239635918 0.22287526354436 mirMAP -0.136306219189162 0.010470892898055 NA NA NA hsa-miR-21-5p HHIP 2.21515015440792 6.0468197386674e-49 -1.31939460601956 0.00559616638963854 mirMAP -0.596083539336118 0.000228494599173891 NA NA NA hsa-miR-18a-5p HIF3A 2.04701000113742 1.30593450319289e-12 -1.90205421842713 1.13270039214825e-05 mirMAP -0.568817688480163 4.21055713077895e-11 NA NA NA hsa-miR-146b-5p HIPK3 2.23105707690238 3.83997814011313e-23 -0.453460252737316 0.00223114894328011 MirTarget -0.217056333592347 1.93942269230696e-09 NA NA NA hsa-miR-200a-3p HIPK3 2.02394729844446 2.21240501925011e-08 -0.453460252737316 0.00223114894328011 MirTarget -0.201904389700107 1.15823033948785e-18 NA NA NA hsa-miR-200b-3p HIPK3 2.06025765178663 3.07718049337497e-10 -0.453460252737316 0.00223114894328011 MirTarget;TargetScan -0.204587896775969 8.68837435752391e-16 NA NA NA hsa-miR-21-5p HIPK3 2.21515015440792 6.0468197386674e-49 -0.453460252737316 0.00223114894328011 MirTarget -0.246110364440365 7.71316560286247e-07 NA NA NA hsa-miR-146b-5p HIVEP2 2.23105707690238 3.83997814011313e-23 -0.000288491818339232 0.998225122290243 miRanda -0.105085643956825 0.00104689816959862 NA NA NA hsa-miR-18a-5p HLF 2.04701000113742 1.30593450319289e-12 -2.44260242805055 4.45000537404727e-11 MirTarget -0.788261965205109 2.01574213307597e-29 NA NA NA hsa-miR-196a-5p HLF 5.05945965885472 4.48343841468539e-25 -2.44260242805055 4.45000537404727e-11 miRNATAP -0.354485849278173 2.25093159033466e-17 NA NA NA hsa-miR-196b-5p HLF 4.51951031652328 7.04026169031626e-18 -2.44260242805055 4.45000537404727e-11 miRNATAP -0.386152884981023 8.99843267206208e-24 NA NA NA hsa-miR-200b-3p HLF 2.06025765178663 3.07718049337497e-10 -2.44260242805055 4.45000537404727e-11 MirTarget;TargetScan -0.7185481952653 2.94512521460051e-31 NA NA NA hsa-miR-146b-5p HMGCLL1 2.23105707690238 3.83997814011313e-23 -2.89944214202299 2.19506100154152e-12 miRanda -0.825006679178148 5.94073554817981e-16 NA NA NA hsa-miR-21-5p HMX3 2.21515015440792 6.0468197386674e-49 -0.954794769046294 0.099247146872649 mirMAP -0.624365624744644 0.00148333892065934 NA NA NA hsa-miR-1-3p HOOK1 -2.73171785118192 3.4424534921136e-12 1.14439125049419 7.85249427739804e-06 MirTarget -0.251067192369951 1.86880944393019e-11 NA NA NA hsa-miR-192-5p HOOK3 2.0867723747501 3.57854249239079e-08 0.272600395714842 0.0995732135990335 miRNAWalker2_validate -0.23683882489823 2.86840487058371e-23 NA NA NA hsa-miR-194-5p HOOK3 2.24386881692218 9.35116329002209e-11 0.272600395714842 0.0995732135990335 MirTarget -0.207513833871182 7.78932051781772e-15 NA NA NA hsa-miR-146b-5p HOPX 2.23105707690238 3.83997814011313e-23 -0.209081818115939 0.483203944924144 miRanda -0.188161608281054 0.0113419622388768 NA NA NA hsa-miR-183-5p HOXA5 2.08412478942637 1.08931431254487e-10 -0.700496721763648 0.00235992010111307 miRNAWalker2_validate -0.347319919404707 1.77741173192178e-18 NA NA NA hsa-miR-200b-3p HOXA5 2.06025765178663 3.07718049337497e-10 -0.700496721763648 0.00235992010111307 TargetScan -0.310178603283595 5.68005372389173e-15 NA NA NA hsa-miR-335-3p HOXA5 2.29463721765513 4.1956113745077e-18 -0.700496721763648 0.00235992010111307 mirMAP -0.246014050711389 5.99110106993337e-07 NA NA NA hsa-miR-146b-5p HOXB3 2.23105707690238 3.83997814011313e-23 0.404660196732005 0.0703619840497218 miRanda -0.190965102407014 0.000587490752078767 NA NA NA hsa-miR-146b-5p HOXB8 2.23105707690238 3.83997814011313e-23 -0.151724835769523 0.776748784960277 PITA;miRanda -0.384934541172857 0.00383323720879018 NA NA NA hsa-miR-200a-3p HPCAL4 2.02394729844446 2.21240501925011e-08 -3.30571688739834 1.29667683864775e-16 mirMAP -0.488878966851429 2.45226076572845e-13 NA NA NA hsa-miR-335-3p HPCAL4 2.29463721765513 4.1956113745077e-18 -3.30571688739834 1.29667683864775e-16 mirMAP -0.613799728827541 3.87380717075205e-12 NA NA NA hsa-miR-92a-1-5p HPCAL4 2.04820501765632 9.32117486799495e-13 -3.30571688739834 1.29667683864775e-16 MirTarget -0.519153457565655 1.45775294727674e-09 NA NA NA hsa-miR-146b-5p HPGD 2.23105707690238 3.83997814011313e-23 -3.40877453112197 1.9533273364812e-17 miRanda -0.52916528836848 4.6304710095791e-07 NA NA NA hsa-miR-335-3p HPGD 2.29463721765513 4.1956113745077e-18 -3.40877453112197 1.9533273364812e-17 mirMAP -0.382492981430252 3.02177314396906e-05 NA NA NA hsa-miR-146b-5p HS1BP3 2.23105707690238 3.83997814011313e-23 -0.206938620862182 0.0588432688874684 mirMAP -0.139730681814113 1.66728995459265e-07 NA NA NA hsa-miR-200b-3p HS3ST3A1 2.06025765178663 3.07718049337497e-10 0.071423741699323 0.775993889593196 MirTarget;TargetScan -0.281722879818435 1.12078756796853e-10 NA NA NA hsa-miR-146b-5p HS6ST2 2.23105707690238 3.83997814011313e-23 -1.16779890022091 0.0149306628356469 miRanda -0.604506349337187 3.01719645979569e-07 NA NA NA hsa-miR-135b-5p HS6ST3 2.80066701698235 2.12546333413447e-11 -3.15893212511887 5.78851772616936e-10 MirTarget -0.45501889352116 1.59825069561426e-09 NA NA NA hsa-miR-200a-3p HS6ST3 2.02394729844446 2.21240501925011e-08 -3.15893212511887 5.78851772616936e-10 MirTarget -0.528340977168591 3.16827720155377e-10 NA NA NA hsa-miR-21-5p HSD17B4 2.21515015440792 6.0468197386674e-49 -0.593881672995398 6.60972059099526e-08 MirTarget -0.114422784540745 0.00264549748172124 NA NA NA hsa-miR-146b-5p HSD17B6 2.23105707690238 3.83997814011313e-23 -1.29492928780095 2.22150963099243e-08 miRanda -0.279762869327571 1.68626976011296e-06 NA NA NA hsa-miR-1-3p HSP90B1 -2.73171785118192 3.4424534921136e-12 0.42591397534842 4.38034046507526e-05 MirTarget -0.119785514979974 6.04535687464213e-16 NA NA NA hsa-miR-135b-5p HSPA12A 2.80066701698235 2.12546333413447e-11 -0.340279102192054 0.164413467090745 mirMAP -0.178082746009316 4.593972271753e-07 NA NA NA hsa-miR-335-3p HSPA12A 2.29463721765513 4.1956113745077e-18 -0.340279102192054 0.164413467090745 mirMAP -0.249359131816391 1.70517844531007e-06 NA NA NA hsa-miR-935 HSPA12A 2.321600496365 1.00042201726114e-07 -0.340279102192054 0.164413467090745 MirTarget -0.203479154036591 3.21997922694218e-09 NA NA NA hsa-miR-146b-5p HSPA1A 2.23105707690238 3.83997814011313e-23 -0.370346353218471 0.148021401695504 miRanda -0.262983018340598 3.19193692195064e-05 NA NA NA hsa-miR-192-5p HSPA2 2.0867723747501 3.57854249239079e-08 -1.54334573172528 1.46012961305722e-08 miRNAWalker2_validate -0.437505144941808 1.87496258217843e-28 NA NA NA hsa-miR-92a-1-5p HSPB6 2.04820501765632 9.32117486799495e-13 -2.79338238816287 1.40727131139274e-07 MirTarget -0.980242437583828 8.71631578795786e-21 NA NA NA hsa-miR-146b-3p HSPB7 2.08650140817622 5.3293570720033e-22 -2.26754880228437 6.94388608622507e-06 miRNATAP -0.830435560375328 1.54810223654223e-10 NA NA NA hsa-miR-192-5p HSPB7 2.0867723747501 3.57854249239079e-08 -2.26754880228437 6.94388608622507e-06 mirMAP -0.737497050810594 2.03226310472373e-23 NA NA NA hsa-miR-1-3p HSPD1 -2.73171785118192 3.4424534921136e-12 1.09026136229175 5.42429006906136e-14 miRTarBase;MirTarget -0.216090768118312 9.44287457144795e-26 NA NA NA hsa-miR-146b-5p HSPG2 2.23105707690238 3.83997814011313e-23 0.661442901032608 0.000453126923030142 miRanda -0.114419691049392 0.0160034591421102 NA NA NA hsa-miR-183-5p HTR2A 2.08412478942637 1.08931431254487e-10 -0.0710788448464774 0.841841357342253 MirTarget -0.469582409257977 3.07258837239865e-14 NA NA NA hsa-miR-200b-3p HTR2A 2.06025765178663 3.07718049337497e-10 -0.0710788448464774 0.841841357342253 MirTarget -0.479573110611342 3.27639967696133e-15 NA NA NA hsa-miR-335-3p HTR2A 2.29463721765513 4.1956113745077e-18 -0.0710788448464774 0.841841357342253 mirMAP -0.355810831776656 2.6907498738308e-06 NA NA NA hsa-miR-135b-5p ICA1L 2.80066701698235 2.12546333413447e-11 -0.724571877068585 0.00108619408081636 MirTarget -0.214522667397828 1.21578785387026e-11 NA NA NA hsa-miR-146b-3p ICA1L 2.08650140817622 5.3293570720033e-22 -0.724571877068585 0.00108619408081636 PITA -0.373145252851383 3.45739370845819e-11 NA NA NA hsa-miR-192-5p ID4 2.0867723747501 3.57854249239079e-08 -1.64381994370786 3.62108939915692e-12 miRNAWalker2_validate -0.290354258738131 2.849515978583e-15 NA NA NA hsa-miR-183-5p IDNK 2.08412478942637 1.08931431254487e-10 -1.01552280239501 1.23791772005412e-11 MirTarget -0.10543810344365 0.000185692923260929 NA NA NA hsa-miR-200a-3p IDS 2.02394729844446 2.21240501925011e-08 -0.0995092469681822 0.452237040895841 mirMAP -0.156896863305018 2.76678951223306e-14 NA NA NA hsa-miR-200b-3p IDS 2.06025765178663 3.07718049337497e-10 -0.0995092469681822 0.452237040895841 TargetScan -0.163627855404718 6.60702722108642e-13 NA NA NA hsa-miR-335-3p IDS 2.29463721765513 4.1956113745077e-18 -0.0995092469681822 0.452237040895841 mirMAP -0.130708085024068 3.29551339168642e-06 NA NA NA hsa-miR-92a-1-5p IFIT1 2.04820501765632 9.32117486799495e-13 0.0225104106493856 0.930076933022927 MirTarget -0.165446169316845 0.00180253951856883 NA NA NA hsa-miR-183-5p IGDCC4 2.08412478942637 1.08931431254487e-10 -0.124567333125467 0.555726093955755 mirMAP -0.149904240352666 8.46956623281243e-05 NA NA NA hsa-miR-200a-3p IGDCC4 2.02394729844446 2.21240501925011e-08 -0.124567333125467 0.555726093955755 miRNATAP -0.157731328018666 3.85231791041017e-06 NA NA NA hsa-miR-141-5p IGF1R 2.13747696823946 1.73124674554872e-11 0.116961071763603 0.57112438908184 mirMAP -0.129299551872751 0.000639254010113562 27648145 Insulin-like growth factor 1 receptor IGF1R was overexpressed in AGS cells to investigate miR-141 mechanism gastric cancer hsa-miR-183-5p IGF1R 2.08412478942637 1.08931431254487e-10 0.116961071763603 0.57112438908184 miRNAWalker2_validate -0.108412615681544 0.00383685739243794 NA NA NA hsa-miR-192-5p IGF1R 2.0867723747501 3.57854249239079e-08 0.116961071763603 0.57112438908184 miRNAWalker2_validate -0.147175389757737 3.89731047961255e-06 NA NA NA hsa-miR-194-5p IGF1R 2.24386881692218 9.35116329002209e-11 0.116961071763603 0.57112438908184 miRNAWalker2_validate;miRTarBase;miRNATAP -0.139203332288475 5.93692812368786e-05 NA NA NA hsa-miR-192-5p IGF2 2.0867723747501 3.57854249239079e-08 0.847971814336397 0.0384171333184512 mirMAP -0.211833680052481 0.000963243771178195 NA NA NA hsa-miR-200a-3p IGF2 2.02394729844446 2.21240501925011e-08 0.847971814336397 0.0384171333184512 MirTarget -0.240494037581915 0.000331938332830703 NA NA NA hsa-miR-135b-5p IGFBP5 2.80066701698235 2.12546333413447e-11 -0.805513625701275 0.00105250959314417 mirMAP -0.253498614085689 3.63961892337397e-13 NA NA NA hsa-miR-141-5p IGFBP5 2.13747696823946 1.73124674554872e-11 -0.805513625701275 0.00105250959314417 mirMAP -0.365508350777064 2.1636124287564e-17 NA NA NA hsa-miR-146b-5p IGFBP5 2.23105707690238 3.83997814011313e-23 -0.805513625701275 0.00105250959314417 MirTarget;PITA;miRanda -0.264984316906024 1.45801803287068e-05 NA NA NA hsa-miR-18a-5p IGFBP5 2.04701000113742 1.30593450319289e-12 -0.805513625701275 0.00105250959314417 mirMAP -0.350134167679505 3.29754308457494e-13 NA NA NA hsa-miR-200a-5p IGFBP5 2.19152245759943 3.17968183522514e-11 -0.805513625701275 0.00105250959314417 mirMAP -0.35203948564084 2.16833792576476e-17 NA NA NA hsa-miR-146b-5p IGSF1 2.23105707690238 3.83997814011313e-23 -1.56519148367387 0.00072224183946043 PITA;miRanda;miRNATAP -0.578802937303451 4.33818500020528e-07 NA NA NA hsa-miR-200b-3p IGSF10 2.06025765178663 3.07718049337497e-10 -1.75122160075477 5.54542106173822e-06 MirTarget -0.457509627671789 1.99234635398502e-11 NA NA NA hsa-miR-335-3p IGSF10 2.29463721765513 4.1956113745077e-18 -1.75122160075477 5.54542106173822e-06 mirMAP -0.398573844692678 1.86287137107434e-06 NA NA NA hsa-miR-141-5p IGSF3 2.13747696823946 1.73124674554872e-11 -0.696165647878072 0.000303013857178524 miRNATAP -0.1055429175818 0.00324681681239443 NA NA NA hsa-miR-200b-3p IGSF3 2.06025765178663 3.07718049337497e-10 -0.696165647878072 0.000303013857178524 TargetScan -0.127076062039306 0.000263731602032531 NA NA NA hsa-miR-146b-5p IGSF9B 2.23105707690238 3.83997814011313e-23 0.239398049711897 0.455821977868752 miRanda -0.270037686423423 0.000696094133138812 NA NA NA hsa-miR-192-5p IKZF2 2.0867723747501 3.57854249239079e-08 -0.283771698245864 0.194197717049752 MirTarget -0.109885075742121 0.00128943344636315 NA NA NA hsa-miR-335-3p IKZF2 2.29463721765513 4.1956113745077e-18 -0.283771698245864 0.194197717049752 mirMAP -0.108254188243401 0.0220820331528489 NA NA NA hsa-miR-21-5p IL12A 2.21515015440792 6.0468197386674e-49 -0.664804348874484 0.0119080927174871 MirTarget -0.231566796226958 0.0102549677605847 NA NA NA hsa-miR-335-3p IL16 2.29463721765513 4.1956113745077e-18 -0.909247520771211 7.52734399467428e-05 MirTarget;mirMAP -0.282776680648799 8.16548788427096e-09 NA NA NA hsa-miR-18a-5p IL17B 2.04701000113742 1.30593450319289e-12 -1.21363197035382 1.75158380383813e-05 MirTarget -0.437698253611808 2.1563496699133e-15 NA NA NA hsa-miR-135b-5p IL17RD 2.80066701698235 2.12546333413447e-11 -0.0188801323132464 0.948726066054448 mirMAP -0.172906816020161 5.06160098753071e-05 NA NA NA hsa-miR-335-3p IL17RD 2.29463721765513 4.1956113745077e-18 -0.0188801323132464 0.948726066054448 MirTarget;mirMAP -0.187910213249408 0.00296987071692912 NA NA NA hsa-miR-192-5p IL1R1 2.0867723747501 3.57854249239079e-08 0.0774863445440346 0.657011719623057 miRNAWalker2_validate -0.143361190621522 8.17071706780348e-08 NA NA NA hsa-miR-335-3p IL1R1 2.29463721765513 4.1956113745077e-18 0.0774863445440346 0.657011719623057 mirMAP -0.188327541580733 3.43342483254498e-07 NA NA NA hsa-miR-135b-5p IL1RL1 2.80066701698235 2.12546333413447e-11 -1.19725813928292 0.000886529871449767 mirMAP -0.17600119906862 0.000933026108309363 NA NA NA hsa-miR-135b-5p IL6R 2.80066701698235 2.12546333413447e-11 -1.21161276372315 1.03367113948549e-09 mirMAP -0.138010681660297 3.35550660139864e-06 NA NA NA hsa-miR-141-5p IL6R 2.13747696823946 1.73124674554872e-11 -1.21161276372315 1.03367113948549e-09 MirTarget -0.154108356158782 3.94728696393256e-05 NA NA NA hsa-miR-146b-5p IL6R 2.23105707690238 3.83997814011313e-23 -1.21161276372315 1.03367113948549e-09 miRanda -0.119662585345475 0.0194175962393968 NA NA NA hsa-miR-200a-3p IL6R 2.02394729844446 2.21240501925011e-08 -1.21161276372315 1.03367113948549e-09 MirTarget -0.180898698182907 3.84982463404944e-08 NA NA NA hsa-miR-21-5p IL6R 2.21515015440792 6.0468197386674e-49 -1.21161276372315 1.03367113948549e-09 MirTarget;miRNATAP -0.425484681993678 2.96975015882595e-10 NA NA NA hsa-miR-135b-5p IL6ST 2.80066701698235 2.12546333413447e-11 -0.401511913072166 0.00675820073922165 mirMAP -0.168738282264313 3.07180928856146e-16 NA NA NA hsa-miR-146b-5p IL6ST 2.23105707690238 3.83997814011313e-23 -0.401511913072166 0.00675820073922165 miRanda -0.11105541880136 0.00268757436584392 NA NA NA hsa-miR-192-5p IL6ST 2.0867723747501 3.57854249239079e-08 -0.401511913072166 0.00675820073922165 miRNAWalker2_validate -0.179368286957245 4.34841282521846e-16 NA NA NA hsa-miR-200a-5p IL6ST 2.19152245759943 3.17968183522514e-11 -0.401511913072166 0.00675820073922165 mirMAP -0.231223000858082 3.87401725331664e-21 NA NA NA hsa-miR-200b-3p IL6ST 2.06025765178663 3.07718049337497e-10 -0.401511913072166 0.00675820073922165 TargetScan;mirMAP -0.225425747172054 1.88662933456835e-19 NA NA NA hsa-miR-21-5p IL6ST 2.21515015440792 6.0468197386674e-49 -0.401511913072166 0.00675820073922165 mirMAP -0.197255886906842 8.23312870360343e-05 NA NA NA hsa-miR-335-3p IL6ST 2.29463721765513 4.1956113745077e-18 -0.401511913072166 0.00675820073922165 MirTarget;mirMAP -0.230582265903267 5.73194193691726e-14 NA NA NA hsa-miR-335-3p IL7R 2.29463721765513 4.1956113745077e-18 -0.0580891903764487 0.822485344953704 mirMAP -0.168485636327691 0.00251189798098582 NA NA NA hsa-miR-141-5p ILDR2 2.13747696823946 1.73124674554872e-11 1.16237294137083 0.00026098079531004 MirTarget -0.215693542624293 0.000260372243237284 NA NA NA hsa-miR-92a-1-5p ILDR2 2.04820501765632 9.32117486799495e-13 1.16237294137083 0.00026098079531004 MirTarget -0.164913664913026 0.0136602082707318 NA NA NA hsa-miR-335-3p ILK 2.29463721765513 4.1956113745077e-18 -0.739811886053165 2.2257148284888e-07 MirTarget -0.244325099498523 2.51148763203618e-16 NA NA NA hsa-miR-146b-5p IMMP2L 2.23105707690238 3.83997814011313e-23 -0.565538828322231 0.000152554189450385 miRanda -0.145483967366733 9.63094081727453e-05 NA NA NA hsa-miR-200b-3p IMMP2L 2.06025765178663 3.07718049337497e-10 -0.565538828322231 0.000152554189450385 MirTarget;TargetScan -0.109898033224479 4.41644228461287e-05 NA NA NA hsa-miR-200b-3p INPP4A 2.06025765178663 3.07718049337497e-10 0.070243412672542 0.535628784667479 TargetScan -0.14848743391678 1.61520128947153e-14 NA NA NA hsa-miR-200a-5p INPP4B 2.19152245759943 3.17968183522514e-11 -0.0973820149125961 0.605032254447324 mirMAP -0.154209258953817 2.81878722886767e-06 NA NA NA hsa-miR-192-5p INPP5F 2.0867723747501 3.57854249239079e-08 0.0457326310808011 0.7032738714146 miRNAWalker2_validate -0.140301640107846 3.02355923505294e-15 NA NA NA hsa-miR-935 INSM1 2.321600496365 1.00042201726114e-07 -1.01875553942904 0.0786713090884283 PITA -0.296573273532574 0.000368171839438414 NA NA NA hsa-miR-146b-5p INTU 2.23105707690238 3.83997814011313e-23 -0.242061924257791 0.152368612449829 miRanda -0.120764234334298 0.00409488186776476 NA NA NA hsa-miR-146b-5p IP6K3 2.23105707690238 3.83997814011313e-23 -2.39919117665381 1.74241600926829e-09 miRanda -0.635367090429708 1.68355758562864e-10 NA NA NA hsa-miR-196a-5p IQCJ-SCHIP1 5.05945965885472 4.48343841468539e-25 -0.348035812428486 0.134169166438994 MirTarget -0.135994980236448 2.23855157740321e-07 NA NA NA hsa-miR-196b-5p IQCJ-SCHIP1 4.51951031652328 7.04026169031626e-18 -0.348035812428486 0.134169166438994 MirTarget -0.149803871450937 1.02340363008736e-09 NA NA NA hsa-miR-200a-3p IQCJ-SCHIP1 2.02394729844446 2.21240501925011e-08 -0.348035812428486 0.134169166438994 MirTarget -0.423308353750502 1.9360023688999e-37 NA NA NA hsa-miR-200b-3p IQCJ-SCHIP1 2.06025765178663 3.07718049337497e-10 -0.348035812428486 0.134169166438994 TargetScan -0.461830121743074 7.77401758045142e-37 NA NA NA hsa-miR-335-3p IRAK3 2.29463721765513 4.1956113745077e-18 -0.348797387038069 0.15544292867076 mirMAP -0.240721095373149 4.29151430183264e-06 NA NA NA hsa-miR-200a-3p IRF2BPL 2.02394729844446 2.21240501925011e-08 -0.347058176218165 0.0033304436134852 miRNATAP -0.18159357307577 1.68994548604253e-24 NA NA NA hsa-miR-183-5p IRS1 2.08412478942637 1.08931431254487e-10 -0.0263168100229603 0.888545775357123 MirTarget;miRNATAP -0.189726830921609 1.23209031057426e-08 NA NA NA hsa-miR-200b-3p IRS1 2.06025765178663 3.07718049337497e-10 -0.0263168100229603 0.888545775357123 TargetScan -0.178970489896676 5.95671901451481e-08 26314828 Taken together our results suggest that miR-200 may activate AKT in lung adenocarcinoma cells through a FOG2-independent mechanism involving IRS-1 lung cancer hsa-miR-200a-3p IRS2 2.02394729844446 2.21240501925011e-08 -0.121154049271723 0.65337679198659 MirTarget;miRNATAP -0.116024238444409 0.00865589506670665 NA NA NA hsa-miR-935 IRS2 2.321600496365 1.00042201726114e-07 -0.121154049271723 0.65337679198659 MirTarget;PITA -0.150144871858628 9.81454340963404e-05 NA NA NA hsa-miR-18a-5p IRS4 2.04701000113742 1.30593450319289e-12 -2.36249743886607 2.07501297504123e-05 miRNAWalker2_validate -0.511005690284128 5.83998243326969e-06 NA NA NA hsa-miR-21-5p ISCU 2.21515015440792 6.0468197386674e-49 -0.602780016325892 1.09946571189988e-09 miRNAWalker2_validate;miRTarBase -0.212248702001438 2.24306394488696e-10 NA NA NA hsa-miR-335-3p ISL1 2.29463721765513 4.1956113745077e-18 -0.723804750422264 0.0483125739910108 mirMAP -0.360070049039765 4.33950248092439e-06 NA NA NA hsa-miR-146b-5p ISM2 2.23105707690238 3.83997814011313e-23 0.870746574974917 0.07299207136836 miRanda -0.316094519071649 0.00920068974155576 NA NA NA hsa-miR-141-5p ITGA1 2.13747696823946 1.73124674554872e-11 0.115262071098885 0.568719105297938 MirTarget -0.364604959558584 2.55256665935546e-27 NA NA NA hsa-miR-200a-5p ITGA1 2.19152245759943 3.17968183522514e-11 0.115262071098885 0.568719105297938 mirMAP -0.336574564423367 9.66249893880501e-25 NA NA NA hsa-miR-200b-3p ITGA1 2.06025765178663 3.07718049337497e-10 0.115262071098885 0.568719105297938 MirTarget -0.339222191248936 1.84422520780891e-24 NA NA NA hsa-miR-21-5p ITGA1 2.21515015440792 6.0468197386674e-49 0.115262071098885 0.568719105297938 mirMAP -0.227875606178553 0.000844966574930433 NA NA NA hsa-miR-335-3p ITGA1 2.29463721765513 4.1956113745077e-18 0.115262071098885 0.568719105297938 mirMAP -0.216729493106044 4.26824401857082e-07 NA NA NA hsa-miR-183-5p ITGA5 2.08412478942637 1.08931431254487e-10 0.451610603015354 0.0352433294585663 miRNAWalker2_validate -0.262508236266232 3.15413351773057e-12 NA NA NA hsa-miR-183-5p ITGA8 2.08412478942637 1.08931431254487e-10 -1.91389446067294 3.08011993269904e-08 miRNAWalker2_validate -0.558513541677476 1.6334610963548e-20 NA NA NA hsa-miR-21-5p ITGA8 2.21515015440792 6.0468197386674e-49 -1.91389446067294 3.08011993269904e-08 mirMAP -0.952913612008529 5.57352645287147e-17 NA NA NA hsa-miR-335-3p ITGA8 2.29463721765513 4.1956113745077e-18 -1.91389446067294 3.08011993269904e-08 mirMAP -0.595661020170064 2.31149219290143e-16 NA NA NA hsa-miR-141-5p ITGA9 2.13747696823946 1.73124674554872e-11 -0.825924039856462 0.00174155829133973 MirTarget -0.458715397150148 1.47861761539656e-24 NA NA NA hsa-miR-194-5p ITGA9 2.24386881692218 9.35116329002209e-11 -0.825924039856462 0.00174155829133973 miRNAWalker2_validate;miRTarBase -0.304755562790261 2.04883725664225e-12 NA NA NA hsa-miR-200b-3p ITGA9 2.06025765178663 3.07718049337497e-10 -0.825924039856462 0.00174155829133973 mirMAP -0.457920037358817 6.75510224611362e-26 24518294;26334393 β1 integrin inhibition elicits a prometastatic switch through the TGFβ miR 200 ZEB network in E cadherin positive triple negative breast cancer;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ; breast cancer;esophageal cancer hsa-miR-183-5p ITGB1 2.08412478942637 1.08931431254487e-10 0.523596429686159 0.000169768671621539 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.131986789220149 1.4627928835727e-07 NA NA NA hsa-miR-192-5p ITGB1 2.0867723747501 3.57854249239079e-08 0.523596429686159 0.000169768671621539 miRNAWalker2_validate -0.150999493689047 9.20856253461791e-13 NA NA NA hsa-miR-146b-5p ITGB3 2.23105707690238 3.83997814011313e-23 -0.0112515540123894 0.957514601637104 miRanda -0.195758557971665 0.000176176544530511 NA NA NA hsa-miR-92a-1-5p ITIH5 2.04820501765632 9.32117486799495e-13 -1.49428202953031 2.35582742000469e-06 MirTarget -0.474158780576766 1.36258945044874e-13 NA NA NA hsa-miR-141-5p ITPKB 2.13747696823946 1.73124674554872e-11 -0.703543595422723 0.00105945909085452 mirMAP -0.469244428715635 1.42541820926898e-43 NA NA NA hsa-miR-146b-5p ITPKB 2.23105707690238 3.83997814011313e-23 -0.703543595422723 0.00105945909085452 miRanda -0.356916341508461 6.76013034533953e-12 NA NA NA hsa-miR-183-5p ITPKB 2.08412478942637 1.08931431254487e-10 -0.703543595422723 0.00105945909085452 miRNAWalker2_validate -0.423524568296436 2.86804480162215e-34 NA NA NA hsa-miR-194-5p ITPKB 2.24386881692218 9.35116329002209e-11 -0.703543595422723 0.00105945909085452 MirTarget;miRNATAP -0.357891038486921 5.44066281377875e-27 NA NA NA hsa-miR-146b-5p ITPR1 2.23105707690238 3.83997814011313e-23 -0.978205239289609 1.76770291502282e-06 miRanda -0.305476941520721 1.57719967598307e-09 NA NA NA hsa-miR-200b-3p ITPR1 2.06025765178663 3.07718049337497e-10 -0.978205239289609 1.76770291502282e-06 TargetScan -0.354140928419501 5.23323926103515e-25 NA NA NA hsa-miR-335-3p ITPR1 2.29463721765513 4.1956113745077e-18 -0.978205239289609 1.76770291502282e-06 mirMAP -0.372934626535387 1.03266260186836e-18 NA NA NA hsa-miR-141-5p ITPRIP 2.13747696823946 1.73124674554872e-11 -0.166548738859446 0.282531567122101 MirTarget -0.151517249791336 5.83643758604557e-08 NA NA NA hsa-miR-141-5p ITSN1 2.13747696823946 1.73124674554872e-11 -0.174910914321985 0.0772411521730026 mirMAP -0.125255811216361 6.80415610067556e-13 NA NA NA hsa-miR-146b-5p ITSN1 2.23105707690238 3.83997814011313e-23 -0.174910914321985 0.0772411521730026 miRanda -0.10047415548338 3.61952946812644e-05 NA NA NA hsa-miR-200a-5p ITSN1 2.19152245759943 3.17968183522514e-11 -0.174910914321985 0.0772411521730026 mirMAP -0.109490527362876 1.04661299924896e-10 NA NA NA hsa-miR-200b-3p ITSN1 2.06025765178663 3.07718049337497e-10 -0.174910914321985 0.0772411521730026 TargetScan -0.109462423482328 1.89839791367856e-10 NA NA NA hsa-miR-135b-5p JAKMIP2 2.80066701698235 2.12546333413447e-11 -1.38795790540687 1.75125368830264e-06 MirTarget -0.372908670256748 3.13028877870011e-20 NA NA NA hsa-miR-200b-3p JAKMIP2 2.06025765178663 3.07718049337497e-10 -1.38795790540687 1.75125368830264e-06 TargetScan -0.52555477860223 9.42556314845875e-28 NA NA NA hsa-miR-200b-3p JAKMIP3 2.06025765178663 3.07718049337497e-10 -0.453817101961681 0.0924761400087551 TargetScan -0.272092990552816 9.79194461811902e-09 NA NA NA hsa-miR-335-3p JAM2 2.29463721765513 4.1956113745077e-18 -1.74450335166658 1.94291240042202e-10 mirMAP -0.57107060052561 3.0520453208488e-24 NA NA NA hsa-miR-183-5p JAM3 2.08412478942637 1.08931431254487e-10 -0.792444960261859 0.000502885115591702 MirTarget -0.477852873039394 2.98751844994044e-40 NA NA NA hsa-miR-146b-5p JAZF1 2.23105707690238 3.83997814011313e-23 -0.376602966601115 0.0267725739241035 MirTarget;PITA;miRanda;miRNATAP -0.178158162543233 2.23703892434047e-05 NA NA NA hsa-miR-196a-5p JAZF1 5.05945965885472 4.48343841468539e-25 -0.376602966601115 0.0267725739241035 miRNATAP -0.124680665620801 4.74701735413406e-11 NA NA NA hsa-miR-196b-5p JAZF1 4.51951031652328 7.04026169031626e-18 -0.376602966601115 0.0267725739241035 miRNATAP -0.148840792973038 1.16462626019237e-17 NA NA NA hsa-miR-200a-3p JAZF1 2.02394729844446 2.21240501925011e-08 -0.376602966601115 0.0267725739241035 MirTarget;miRNATAP -0.270782559390357 1.06505575319756e-26 NA NA NA hsa-miR-200b-3p JAZF1 2.06025765178663 3.07718049337497e-10 -0.376602966601115 0.0267725739241035 MirTarget;TargetScan -0.293911916600013 5.30260186444781e-26 NA NA NA hsa-miR-335-3p JAZF1 2.29463721765513 4.1956113745077e-18 -0.376602966601115 0.0267725739241035 mirMAP -0.288102483900376 1.13359511648109e-16 NA NA NA hsa-miR-146b-5p JDP2 2.23105707690238 3.83997814011313e-23 -0.966549889941349 1.31375922707916e-12 mirMAP -0.187404268700818 6.77132782008216e-08 NA NA NA hsa-miR-335-3p JDP2 2.29463721765513 4.1956113745077e-18 -0.966549889941349 1.31375922707916e-12 mirMAP -0.171953691483625 9.88968001667732e-09 NA NA NA hsa-miR-146b-5p JMY 2.23105707690238 3.83997814011313e-23 -0.265588063934445 0.0620459109443017 mirMAP -0.1992937771773 8.35170400736986e-09 NA NA NA hsa-miR-18a-5p JMY 2.04701000113742 1.30593450319289e-12 -0.265588063934445 0.0620459109443017 miRNATAP -0.20281805141047 1.81844363728619e-13 NA NA NA hsa-miR-194-5p JMY 2.24386881692218 9.35116329002209e-11 -0.265588063934445 0.0620459109443017 mirMAP -0.190652277596442 5.33580918432369e-17 NA NA NA hsa-miR-200b-3p JMY 2.06025765178663 3.07718049337497e-10 -0.265588063934445 0.0620459109443017 TargetScan -0.206801076233742 8.46363040470566e-18 NA NA NA hsa-miR-21-5p JMY 2.21515015440792 6.0468197386674e-49 -0.265588063934445 0.0620459109443017 miRNAWalker2_validate;mirMAP -0.228453213114217 1.56898768866335e-06 NA NA NA hsa-miR-335-3p JMY 2.29463721765513 4.1956113745077e-18 -0.265588063934445 0.0620459109443017 MirTarget -0.160637145472771 9.65382163473855e-08 NA NA NA hsa-miR-146b-5p JPH1 2.23105707690238 3.83997814011313e-23 0.721920574204807 0.0923051541423495 PITA;miRanda -0.242820684941226 0.0236208438714689 NA NA NA hsa-miR-146b-5p JPH3 2.23105707690238 3.83997814011313e-23 -0.805386726103904 0.0133574087640654 miRanda -0.472344936614076 2.66824707605965e-09 NA NA NA hsa-miR-200a-3p JUN 2.02394729844446 2.21240501925011e-08 -0.932062991848233 5.08561574713346e-09 miRNATAP -0.123559771327231 3.2569318830239e-06 NA NA NA hsa-miR-200b-3p JUN 2.06025765178663 3.07718049337497e-10 -0.932062991848233 5.08561574713346e-09 MirTarget;TargetScan -0.127430274428312 1.29168771293238e-05 NA NA NA hsa-miR-146b-5p KALRN 2.23105707690238 3.83997814011313e-23 -0.81945095030466 1.13835675548545e-05 miRanda -0.214808429729269 4.11914863818317e-06 NA NA NA hsa-miR-335-3p KALRN 2.29463721765513 4.1956113745077e-18 -0.81945095030466 1.13835675548545e-05 MirTarget -0.125277650555732 0.00218456654355007 NA NA NA hsa-miR-200b-3p KANK1 2.06025765178663 3.07718049337497e-10 -0.550274438223532 0.0013376758273072 MirTarget;TargetScan -0.1594750549317 1.71503156751433e-07 NA NA NA hsa-miR-335-3p KANK1 2.29463721765513 4.1956113745077e-18 -0.550274438223532 0.0013376758273072 mirMAP -0.108840581859809 0.0034959538222986 NA NA NA hsa-miR-146b-3p KANK2 2.08650140817622 5.3293570720033e-22 -0.932286924516263 1.5601005567271e-05 MirTarget;miRNATAP -0.424433292427156 5.74866579758939e-15 NA NA NA hsa-miR-200b-3p KANK2 2.06025765178663 3.07718049337497e-10 -0.932286924516263 1.5601005567271e-05 TargetScan -0.478444346206633 7.70332188506019e-48 NA NA NA hsa-miR-192-5p KAT2B 2.0867723747501 3.57854249239079e-08 -1.46630453221237 1.85020249256189e-18 miRNAWalker2_validate -0.192444824688028 9.08421646367046e-13 NA NA NA hsa-miR-135b-5p KAT6B 2.80066701698235 2.12546333413447e-11 -0.477684105386874 0.00017500273700996 MirTarget -0.127409212394178 1.99902707927383e-12 NA NA NA hsa-miR-194-5p KAT6B 2.24386881692218 9.35116329002209e-11 -0.477684105386874 0.00017500273700996 MirTarget;miRNATAP -0.117342051720935 3.64018451500779e-08 NA NA NA hsa-miR-200a-3p KAT6B 2.02394729844446 2.21240501925011e-08 -0.477684105386874 0.00017500273700996 MirTarget;miRNATAP -0.116618491519754 1.41282495274018e-08 NA NA NA hsa-miR-135b-5p KATNAL1 2.80066701698235 2.12546333413447e-11 -0.238121876187191 0.227473164378047 mirMAP -0.215393398239518 4.89357932530449e-15 NA NA NA hsa-miR-146b-5p KATNAL1 2.23105707690238 3.83997814011313e-23 -0.238121876187191 0.227473164378047 miRanda -0.236268714482227 1.03155731471105e-06 NA NA NA hsa-miR-192-5p KATNAL1 2.0867723747501 3.57854249239079e-08 -0.238121876187191 0.227473164378047 miRNAWalker2_validate -0.335836630590676 2.19347995558738e-35 NA NA NA hsa-miR-196a-5p KATNAL1 5.05945965885472 4.48343841468539e-25 -0.238121876187191 0.227473164378047 miRNAWalker2_validate;mirMAP -0.118842782955899 9.05831181579923e-08 NA NA NA hsa-miR-196b-5p KATNAL1 4.51951031652328 7.04026169031626e-18 -0.238121876187191 0.227473164378047 mirMAP -0.119411076048785 1.10234542191964e-08 NA NA NA hsa-miR-200b-3p KATNAL1 2.06025765178663 3.07718049337497e-10 -0.238121876187191 0.227473164378047 TargetScan -0.356423069845917 4.70082600332586e-29 NA NA NA hsa-miR-200a-3p KBTBD12 2.02394729844446 2.21240501925011e-08 -2.30850029286481 2.80787511981734e-05 mirMAP -0.417182755630072 4.1358780955236e-06 NA NA NA hsa-miR-335-3p KBTBD12 2.29463721765513 4.1956113745077e-18 -2.30850029286481 2.80787511981734e-05 mirMAP -0.522038030317887 1.27724948519629e-05 NA NA NA hsa-miR-146b-5p KBTBD3 2.23105707690238 3.83997814011313e-23 -0.433182631266432 5.49781064875649e-05 miRNATAP -0.130176435124245 9.69136396569805e-07 NA NA NA hsa-miR-21-5p KBTBD7 2.21515015440792 6.0468197386674e-49 -0.0136055168559617 0.919602264955557 miRNAWalker2_validate -0.111793529919025 0.0142527695926195 NA NA NA hsa-miR-146b-3p KCNA1 2.08650140817622 5.3293570720033e-22 -2.35612495285297 0.000428588551648961 MirTarget;miRNATAP -0.706514681577734 5.31932536154506e-05 NA NA NA hsa-miR-18a-5p KCNA1 2.04701000113742 1.30593450319289e-12 -2.35612495285297 0.000428588551648961 MirTarget;miRNATAP -1.10727800476019 7.60586474251213e-18 NA NA NA hsa-miR-194-5p KCNA1 2.24386881692218 9.35116329002209e-11 -2.35612495285297 0.000428588551648961 mirMAP -0.763232268241196 4.87184171116416e-12 NA NA NA hsa-miR-21-5p KCNA1 2.21515015440792 6.0468197386674e-49 -2.35612495285297 0.000428588551648961 miRNATAP -1.26577207554219 1.69362529566365e-08 NA NA NA hsa-miR-335-3p KCNA1 2.29463721765513 4.1956113745077e-18 -2.35612495285297 0.000428588551648961 mirMAP -0.882942906952054 4.87578467217478e-10 NA NA NA hsa-miR-146b-5p KCNA6 2.23105707690238 3.83997814011313e-23 -1.53132401304961 0.000130733110947696 MirTarget;miRanda -0.361373749802042 0.000324357988665224 NA NA NA hsa-miR-146b-5p KCNB1 2.23105707690238 3.83997814011313e-23 -3.20857676127652 3.00924790818105e-08 mirMAP -1.20165767622039 6.96241829043172e-18 NA NA NA hsa-miR-192-5p KCNB1 2.0867723747501 3.57854249239079e-08 -3.20857676127652 3.00924790818105e-08 mirMAP -0.877681078930108 7.3454281918255e-25 NA NA NA hsa-miR-200b-3p KCNB1 2.06025765178663 3.07718049337497e-10 -3.20857676127652 3.00924790818105e-08 TargetScan -1.16302126630405 3.28261761258998e-35 NA NA NA hsa-miR-135b-5p KCND1 2.80066701698235 2.12546333413447e-11 0.107638878811386 0.583215653009762 MirTarget -0.147762237197817 1.59385110816815e-07 NA NA NA hsa-miR-183-5p KCND1 2.08412478942637 1.08931431254487e-10 0.107638878811386 0.583215653009762 mirMAP -0.289808266011095 4.90159980234011e-18 NA NA NA hsa-miR-183-5p KCND2 2.08412478942637 1.08931431254487e-10 1.01569792564355 0.00135256427875141 MirTarget -0.169509061971952 0.0035526632466788 NA NA NA hsa-miR-200b-3p KCND2 2.06025765178663 3.07718049337497e-10 1.01569792564355 0.00135256427875141 MirTarget;TargetScan -0.280058284022251 7.52238331765221e-07 NA NA NA hsa-miR-200b-3p KCND3 2.06025765178663 3.07718049337497e-10 -1.25081349685282 8.58949377013892e-05 TargetScan -0.358813297918302 1.85696661392149e-10 NA NA NA hsa-miR-146b-5p KCNE4 2.23105707690238 3.83997814011313e-23 -0.567856282931666 0.0250032514109718 miRanda -0.28269428224488 6.21406596388528e-06 NA NA NA hsa-miR-335-3p KCNE4 2.29463721765513 4.1956113745077e-18 -0.567856282931666 0.0250032514109718 mirMAP -0.384638317713521 2.58390625396121e-13 NA NA NA hsa-miR-146b-5p KCNH8 2.23105707690238 3.83997814011313e-23 0.531288998878151 0.272346932031508 miRanda -0.317938122240328 0.00843753245662201 NA NA NA hsa-miR-146b-5p KCNIP3 2.23105707690238 3.83997814011313e-23 -1.32549700445121 5.16294830935081e-05 miRNATAP -0.647996867828543 1.14643480018385e-16 NA NA NA hsa-miR-92a-1-5p KCNIP3 2.04820501765632 9.32117486799495e-13 -1.32549700445121 5.16294830935081e-05 mirMAP -0.533407897538785 2.75804710318002e-16 NA NA NA hsa-miR-200a-3p KCNIP4 2.02394729844446 2.21240501925011e-08 -0.557158238294981 0.00644655719079311 MirTarget -0.206971107993956 2.38014136144104e-10 NA NA NA hsa-miR-146b-5p KCNJ16 2.23105707690238 3.83997814011313e-23 -3.4667613373396 1.35548726970099e-09 MirTarget;miRanda -0.457385525132694 0.00187390807328783 NA NA NA hsa-miR-335-3p KCNJ16 2.29463721765513 4.1956113745077e-18 -3.4667613373396 1.35548726970099e-09 mirMAP -0.347283396805306 0.00657415021680493 NA NA NA hsa-miR-1-3p KCNJ2 -2.73171785118192 3.4424534921136e-12 0.715735490663241 0.0012607689075355 miRTarBase -0.118340155376623 0.000348075112532277 NA NA NA hsa-miR-200b-3p KCNJ5 2.06025765178663 3.07718049337497e-10 -0.280638251899976 0.333902387273937 mirMAP -0.250065915761005 1.17200124948474e-06 NA NA NA hsa-miR-146b-5p KCNK2 2.23105707690238 3.83997814011313e-23 -1.42404529987974 0.00337739107083879 miRanda -0.497058260536662 3.91063610080412e-05 NA NA NA hsa-miR-183-5p KCNK2 2.08412478942637 1.08931431254487e-10 -1.42404529987974 0.00337739107083879 MirTarget;miRNATAP -0.617952091390433 4.7701381324859e-13 NA NA NA hsa-miR-200a-3p KCNK3 2.02394729844446 2.21240501925011e-08 -2.64642442933474 6.10994924328681e-09 mirMAP -0.713943753220967 4.29864466990009e-24 NA NA NA hsa-miR-21-5p KCNK3 2.21515015440792 6.0468197386674e-49 -2.64642442933474 6.10994924328681e-09 mirMAP -1.32557404493675 6.14665347932417e-19 NA NA NA hsa-miR-935 KCNK3 2.321600496365 1.00042201726114e-07 -2.64642442933474 6.10994924328681e-09 mirMAP -0.519083749266888 5.5107862141859e-16 NA NA NA hsa-miR-146b-5p KCNMA1 2.23105707690238 3.83997814011313e-23 -1.64778839839447 0.0001565420945304 PITA -0.688985395393845 9.80690669584078e-11 NA NA NA hsa-miR-183-5p KCNMA1 2.08412478942637 1.08931431254487e-10 -1.64778839839447 0.0001565420945304 miRNATAP -0.971614323160798 2.22839399986373e-47 NA NA NA hsa-miR-146b-5p KCNMB1 2.23105707690238 3.83997814011313e-23 -2.27064814731121 2.04397127519135e-09 miRanda -0.804265718041287 1.36356607287497e-18 NA NA NA hsa-miR-192-5p KCNMB4 2.0867723747501 3.57854249239079e-08 -0.377768864617567 0.178622044823026 miRNAWalker2_validate -0.284186682402571 2.3229021466011e-11 NA NA NA hsa-miR-133a-3p KCNQ1 -2.63342156915404 5.72661351480585e-12 0.128492375031743 0.689133079037418 miRNAWalker2_validate -0.122358101538187 0.0128387131948567 NA NA NA hsa-miR-200b-3p KCNQ3 2.06025765178663 3.07718049337497e-10 1.1499677240783 1.38640844906971e-05 MirTarget -0.179675576157223 0.00018745059192386 NA NA NA hsa-miR-200b-3p KCNQ4 2.06025765178663 3.07718049337497e-10 -0.902266691172708 0.00407242110892301 TargetScan -0.439702178787104 3.19957625326618e-16 NA NA NA hsa-miR-135b-5p KCNQ5 2.80066701698235 2.12546333413447e-11 -2.00119079597222 6.28495431412454e-08 MirTarget -0.427105135842771 6.03556456556197e-16 NA NA NA hsa-miR-146b-5p KCNQ5 2.23105707690238 3.83997814011313e-23 -2.00119079597222 6.28495431412454e-08 mirMAP -0.377153438496552 5.8573152534324e-05 NA NA NA hsa-miR-192-5p KCNQ5 2.0867723747501 3.57854249239079e-08 -2.00119079597222 6.28495431412454e-08 MirTarget -0.516224801696674 9.82920202681347e-21 NA NA NA hsa-miR-196a-5p KCNQ5 5.05945965885472 4.48343841468539e-25 -2.00119079597222 6.28495431412454e-08 MirTarget;miRNATAP -0.285857420970145 1.18894505331119e-11 NA NA NA hsa-miR-196b-5p KCNQ5 4.51951031652328 7.04026169031626e-18 -2.00119079597222 6.28495431412454e-08 MirTarget;miRNATAP -0.302435535410426 1.37256545283385e-14 NA NA NA hsa-miR-335-3p KCNQ5 2.29463721765513 4.1956113745077e-18 -2.00119079597222 6.28495431412454e-08 MirTarget -0.650704296816811 3.99759287522307e-17 NA NA NA hsa-miR-18a-5p KCNS2 2.04701000113742 1.30593450319289e-12 -1.13465059933003 0.00300428795437821 MirTarget -0.308880050373302 6.47552979285272e-05 NA NA NA hsa-miR-192-5p KCNS3 2.0867723747501 3.57854249239079e-08 -0.43705105181568 0.0619110887481087 miRNAWalker2_validate -0.213541007806964 2.39699501538651e-09 NA NA NA hsa-miR-200a-5p KCNS3 2.19152245759943 3.17968183522514e-11 -0.43705105181568 0.0619110887481087 MirTarget;miRNATAP -0.298538311306497 6.32978538414859e-14 NA NA NA hsa-miR-335-3p KCNT2 2.29463721765513 4.1956113745077e-18 -0.870102840164615 0.00157240788847921 MirTarget;mirMAP -0.430904677308765 5.17495169171358e-14 NA NA NA hsa-miR-135b-5p KCTD10 2.80066701698235 2.12546333413447e-11 -0.108458568601207 0.329711876137741 MirTarget -0.117102665928482 4.30152431462411e-14 NA NA NA hsa-miR-135b-5p KCTD12 2.80066701698235 2.12546333413447e-11 0.00787400313561992 0.970648583019239 MirTarget -0.222387483694289 1.18362752660077e-13 NA NA NA hsa-miR-192-5p KCTD12 2.0867723747501 3.57854249239079e-08 0.00787400313561992 0.970648583019239 miRNAWalker2_validate -0.146028740060388 1.016952649164e-05 NA NA NA hsa-miR-21-5p KCTD12 2.21515015440792 6.0468197386674e-49 0.00787400313561992 0.970648583019239 mirMAP -0.234610983521938 0.00117059669030956 NA NA NA hsa-miR-146b-5p KCTD15 2.23105707690238 3.83997814011313e-23 -0.534965797066081 0.00975039845928537 PITA;miRanda;mirMAP;miRNATAP -0.254358405993637 5.94696860487497e-07 NA NA NA hsa-miR-192-5p KCTD15 2.0867723747501 3.57854249239079e-08 -0.534965797066081 0.00975039845928537 miRNAWalker2_validate -0.3103328862612 1.27643564499081e-25 NA NA NA hsa-miR-200b-3p KCTD15 2.06025765178663 3.07718049337497e-10 -0.534965797066081 0.00975039845928537 MirTarget;TargetScan -0.328778575667664 2.40335129934816e-21 NA NA NA hsa-miR-194-5p KCTD20 2.24386881692218 9.35116329002209e-11 0.00320585632421722 0.976072123046051 MirTarget -0.113352134951937 7.74387506578424e-11 NA NA NA hsa-miR-200a-3p KCTD20 2.02394729844446 2.21240501925011e-08 0.00320585632421722 0.976072123046051 MirTarget -0.113902857533286 1.15527653128906e-11 NA NA NA hsa-miR-146b-3p KCTD21 2.08650140817622 5.3293570720033e-22 -0.467747564016249 1.75160098321922e-06 MirTarget;miRNATAP -0.11146574653333 1.31202180706982e-05 NA NA NA hsa-miR-192-5p KCTD7 2.0867723747501 3.57854249239079e-08 -0.200704573008487 0.213943599487068 mirMAP -0.181657627377269 5.10159444976145e-14 NA NA NA hsa-miR-200a-3p KCTD7 2.02394729844446 2.21240501925011e-08 -0.200704573008487 0.213943599487068 mirMAP -0.23403543869028 1.06180771278162e-21 NA NA NA hsa-miR-200a-5p KCTD7 2.19152245759943 3.17968183522514e-11 -0.200704573008487 0.213943599487068 mirMAP -0.260411213629068 5.13154248567778e-23 NA NA NA hsa-miR-192-5p KDELC2 2.0867723747501 3.57854249239079e-08 0.216170389477556 0.0898833025888716 miRNAWalker2_validate -0.144666965324139 2.76739449674176e-14 NA NA NA hsa-miR-335-3p KDM5D 2.29463721765513 4.1956113745077e-18 -1.15046220061414 0.245673639144148 MirTarget -0.60420489805176 0.00477242169943218 NA NA NA hsa-miR-146b-5p KERA 2.23105707690238 3.83997814011313e-23 -0.0823872497430647 0.867538105918362 miRanda -0.291051242886736 0.0181644146193966 NA NA NA hsa-miR-200a-3p KHDC1 2.02394729844446 2.21240501925011e-08 -0.132494856567608 0.600312604291778 miRNATAP -0.175810729697731 1.77928796294419e-05 NA NA NA hsa-miR-335-3p KIAA0232 2.29463721765513 4.1956113745077e-18 -0.423187252400749 0.000113854621465846 mirMAP -0.107097324252706 5.55117980455282e-06 NA NA NA hsa-miR-200b-3p KIAA0355 2.06025765178663 3.07718049337497e-10 0.222251688753115 0.046704535001662 MirTarget;TargetScan -0.112084749094146 1.05142381086415e-08 NA NA NA hsa-miR-141-5p KIAA0408 2.13747696823946 1.73124674554872e-11 -1.70320950555746 1.48073065619767e-06 MirTarget -0.741975896354451 1.13116252214002e-37 NA NA NA hsa-miR-200a-3p KIAA0408 2.02394729844446 2.21240501925011e-08 -1.70320950555746 1.48073065619767e-06 MirTarget -0.656952207365513 2.6577706917506e-37 NA NA NA hsa-miR-335-3p KIAA0408 2.29463721765513 4.1956113745077e-18 -1.70320950555746 1.48073065619767e-06 MirTarget -0.639993744647268 2.23666352755409e-18 NA NA NA hsa-miR-146b-5p KIAA0430 2.23105707690238 3.83997814011313e-23 -0.304584793472401 0.00340668402488961 miRanda -0.126200647486137 7.69387561960667e-07 NA NA NA hsa-miR-183-5p KIAA0430 2.08412478942637 1.08931431254487e-10 -0.304584793472401 0.00340668402488961 miRNAWalker2_validate -0.175857164640555 4.34989563026152e-24 NA NA NA hsa-miR-200b-3p KIAA0430 2.06025765178663 3.07718049337497e-10 -0.304584793472401 0.00340668402488961 TargetScan -0.131679232779677 2.14834465762948e-13 NA NA NA hsa-miR-335-3p KIAA0430 2.29463721765513 4.1956113745077e-18 -0.304584793472401 0.00340668402488961 mirMAP -0.141302682049357 8.54816413522509e-11 NA NA NA hsa-miR-18a-5p KIAA0513 2.04701000113742 1.30593450319289e-12 -0.784927887721409 7.70902360744078e-06 mirMAP -0.285731735385759 4.60057325383123e-17 NA NA NA hsa-miR-200a-3p KIAA0513 2.02394729844446 2.21240501925011e-08 -0.784927887721409 7.70902360744078e-06 mirMAP -0.123719229198924 1.90432749520761e-05 NA NA NA hsa-miR-335-3p KIAA0513 2.29463721765513 4.1956113745077e-18 -0.784927887721409 7.70902360744078e-06 mirMAP -0.305657038325644 3.86128911100629e-17 NA NA NA hsa-miR-335-3p KIAA0922 2.29463721765513 4.1956113745077e-18 -0.150933100372534 0.342889353419726 MirTarget -0.155040355924446 4.65550699490358e-06 NA NA NA hsa-miR-146b-5p KIAA1161 2.23105707690238 3.83997814011313e-23 -0.703319587123583 0.00023678986438448 miRanda -0.198743344217066 3.11399529998422e-05 NA NA NA hsa-miR-183-5p KIAA1324L 2.08412478942637 1.08931431254487e-10 -0.449705572019655 0.191291570724259 miRNATAP -0.351456183130246 9.34017263892915e-09 NA NA NA hsa-miR-200b-3p KIAA1456 2.06025765178663 3.07718049337497e-10 -0.824815382979913 0.00346285725933416 MirTarget;TargetScan;mirMAP -0.165355525377575 0.00117689038831329 NA NA NA hsa-miR-21-5p KIAA1456 2.21515015440792 6.0468197386674e-49 -0.824815382979913 0.00346285725933416 mirMAP -0.310533924865799 0.00123794918758299 NA NA NA hsa-miR-335-3p KIAA1456 2.29463721765513 4.1956113745077e-18 -0.824815382979913 0.00346285725933416 mirMAP -0.248285556880481 4.46034653164425e-05 NA NA NA hsa-miR-200b-3p KIAA1462 2.06025765178663 3.07718049337497e-10 0.552874008595252 0.00404720415721057 MirTarget;TargetScan -0.23251378670981 3.89438157849664e-12 NA NA NA hsa-miR-183-5p KIAA1614 2.08412478942637 1.08931431254487e-10 -0.672817277076573 0.000878485556645909 mirMAP -0.372810591279165 5.21942763432753e-29 NA NA NA hsa-miR-18a-5p KIAA1614 2.04701000113742 1.30593450319289e-12 -0.672817277076573 0.000878485556645909 mirMAP -0.379566448793511 1.24034970855981e-23 NA NA NA hsa-miR-92a-1-5p KIAA1614 2.04820501765632 9.32117486799495e-13 -0.672817277076573 0.000878485556645909 mirMAP -0.294919612532037 3.44442597727606e-13 NA NA NA hsa-miR-146b-3p KIAA1644 2.08650140817622 5.3293570720033e-22 -1.36705906491291 0.000314678328832303 MirTarget -0.518062712285474 1.28775755080303e-07 NA NA NA hsa-miR-194-5p KIAA1644 2.24386881692218 9.35116329002209e-11 -1.36705906491291 0.000314678328832303 mirMAP -0.490172690302532 2.15476232220061e-15 NA NA NA hsa-miR-200a-3p KIAA1644 2.02394729844446 2.21240501925011e-08 -1.36705906491291 0.000314678328832303 mirMAP -0.633127784338708 3.58195158256019e-29 NA NA NA hsa-miR-141-5p KIAA2022 2.13747696823946 1.73124674554872e-11 -2.80598433621504 1.14813298037395e-09 miRNATAP -0.835001041637857 2.08802901659294e-25 NA NA NA hsa-miR-183-5p KIAA2022 2.08412478942637 1.08931431254487e-10 -2.80598433621504 1.14813298037395e-09 miRNATAP -0.891104360722387 1.32671875750436e-30 NA NA NA hsa-miR-196a-5p KIAA2022 5.05945965885472 4.48343841468539e-25 -2.80598433621504 1.14813298037395e-09 miRNATAP -0.385517651861134 2.17390692036488e-13 NA NA NA hsa-miR-196b-5p KIAA2022 4.51951031652328 7.04026169031626e-18 -2.80598433621504 1.14813298037395e-09 miRNATAP -0.390040594092014 2.10030337186563e-15 NA NA NA hsa-miR-200a-3p KIAA2022 2.02394729844446 2.21240501925011e-08 -2.80598433621504 1.14813298037395e-09 MirTarget -0.711859590535617 4.20271844592372e-23 NA NA NA hsa-miR-335-3p KIAA2022 2.29463721765513 4.1956113745077e-18 -2.80598433621504 1.14813298037395e-09 MirTarget -0.877011267817256 6.48832465385084e-20 NA NA NA hsa-miR-192-5p KIDINS220 2.0867723747501 3.57854249239079e-08 -0.00131844135927928 0.988667768580193 miRNAWalker2_validate -0.102153620573114 1.30170732377819e-13 NA NA NA hsa-miR-183-5p KIF13A 2.08412478942637 1.08931431254487e-10 -0.0225247015031824 0.857124265130631 miRNATAP -0.12211294217033 3.69585113519925e-08 NA NA NA hsa-miR-200a-3p KIF17 2.02394729844446 2.21240501925011e-08 -0.137422250058239 0.480457827871125 MirTarget -0.186768618513137 1.72943173873457e-09 NA NA NA hsa-miR-135b-5p KIF1A 2.80066701698235 2.12546333413447e-11 -2.43068402847898 0.000107271959585404 mirMAP -0.477129229466484 1.91060433944857e-07 NA NA NA hsa-miR-18a-5p KIF1A 2.04701000113742 1.30593450319289e-12 -2.43068402847898 0.000107271959585404 mirMAP -0.535148990144278 2.6882900318049e-05 NA NA NA hsa-miR-192-5p KIF1A 2.0867723747501 3.57854249239079e-08 -2.43068402847898 0.000107271959585404 mirMAP -0.489219510611263 6.03048616773386e-07 NA NA NA hsa-miR-200a-3p KIF1A 2.02394729844446 2.21240501925011e-08 -2.43068402847898 0.000107271959585404 mirMAP -0.574498657363044 1.72351114930101e-08 NA NA NA hsa-miR-194-5p KIF1B 2.24386881692218 9.35116329002209e-11 -0.118034064564058 0.322584301029128 mirMAP -0.102256001237094 2.34642388029751e-07 NA NA NA hsa-miR-200a-3p KIF1B 2.02394729844446 2.21240501925011e-08 -0.118034064564058 0.322584301029128 mirMAP -0.103487004000612 5.76872538073208e-08 NA NA NA hsa-miR-146b-5p KIF1C 2.23105707690238 3.83997814011313e-23 -0.620473772767219 8.45700818698871e-10 mirMAP -0.15746608591584 3.84547667998354e-10 NA NA NA hsa-miR-18a-5p KIF1C 2.04701000113742 1.30593450319289e-12 -0.620473772767219 8.45700818698871e-10 mirMAP -0.111248253888932 6.84587701263415e-08 NA NA NA hsa-miR-1-3p KIF2A -2.73171785118192 3.4424534921136e-12 0.342889432442366 0.00194241298945408 miRTarBase;MirTarget -0.106494928927666 2.29811917762755e-11 NA NA NA hsa-miR-146b-3p KIF3C 2.08650140817622 5.3293570720033e-22 0.294443315663625 0.154960483268872 miRNATAP -0.137980849977219 0.0106048400075716 NA NA NA hsa-miR-146b-5p KIF3C 2.23105707690238 3.83997814011313e-23 0.294443315663625 0.154960483268872 miRanda -0.178715848920697 0.000500329410848022 NA NA NA hsa-miR-200a-3p KIF3C 2.02394729844446 2.21240501925011e-08 0.294443315663625 0.154960483268872 mirMAP -0.291679634353621 2.50662559549904e-20 NA NA NA hsa-miR-92a-1-5p KIF5A 2.04820501765632 9.32117486799495e-13 -1.17412567940313 0.000901231572332803 MirTarget -0.414547678771556 9.81856020251697e-09 NA NA NA hsa-miR-183-5p KIF5C 2.08412478942637 1.08931431254487e-10 -0.770271099699533 0.00199021863152459 miRNAWalker2_validate;MirTarget -0.352565363387306 3.63884452903423e-16 NA NA NA hsa-miR-192-5p KIF5C 2.0867723747501 3.57854249239079e-08 -0.770271099699533 0.00199021863152459 miRNAWalker2_validate -0.26595563932561 2.01769685120343e-12 NA NA NA hsa-miR-335-3p KIF5C 2.29463721765513 4.1956113745077e-18 -0.770271099699533 0.00199021863152459 mirMAP -0.334005693743855 2.09619808178867e-10 NA NA NA hsa-miR-135b-5p KIF6 2.80066701698235 2.12546333413447e-11 -1.15489752011108 0.000793036143804315 mirMAP -0.155380790018447 0.00227023456641887 NA NA NA hsa-miR-141-5p KIF6 2.13747696823946 1.73124674554872e-11 -1.15489752011108 0.000793036143804315 mirMAP -0.36605258017667 4.72485524828012e-09 NA NA NA hsa-miR-200b-3p KIF6 2.06025765178663 3.07718049337497e-10 -1.15489752011108 0.000793036143804315 mirMAP -0.338891836349052 3.0426667121433e-08 NA NA NA hsa-miR-335-3p KIF6 2.29463721765513 4.1956113745077e-18 -1.15489752011108 0.000793036143804315 mirMAP -0.281588564728172 0.000159574179405107 NA NA NA hsa-miR-192-5p KIRREL 2.0867723747501 3.57854249239079e-08 0.573166115265245 0.00487177562588392 mirMAP -0.151868167458667 1.54055126181314e-06 NA NA NA hsa-miR-146b-5p KIT 2.23105707690238 3.83997814011313e-23 -2.18364564416018 1.34619666534478e-12 miRNAWalker2_validate -0.58166429719042 3.24898395259902e-14 NA NA NA hsa-miR-335-3p KIT 2.29463721765513 4.1956113745077e-18 -2.18364564416018 1.34619666534478e-12 mirMAP -0.624082843306586 2.75135700567594e-22 NA NA NA hsa-miR-335-3p KITLG 2.29463721765513 4.1956113745077e-18 -0.0117905614264933 0.949011163097354 MirTarget -0.112165943681707 0.00472572037481932 NA NA NA hsa-miR-335-3p KL 2.29463721765513 4.1956113745077e-18 -1.29424487180348 1.91926325117155e-06 mirMAP -0.430753071669497 5.02669134034695e-14 NA NA NA hsa-miR-192-5p KLF10 2.0867723747501 3.57854249239079e-08 -0.783161616014165 3.23661985875306e-08 miRNAWalker2_validate -0.191276033935484 2.3017710908313e-19 NA NA NA hsa-miR-200b-3p KLF10 2.06025765178663 3.07718049337497e-10 -0.783161616014165 3.23661985875306e-08 TargetScan -0.260290743180181 1.89797596155367e-28 NA NA NA hsa-miR-200a-3p KLF11 2.02394729844446 2.21240501925011e-08 -0.279313477370207 0.0534824444994751 miRNAWalker2_validate;MirTarget -0.161193239002396 1.47324265939492e-12 NA NA NA hsa-miR-200b-3p KLF11 2.06025765178663 3.07718049337497e-10 -0.279313477370207 0.0534824444994751 miRNAWalker2_validate -0.17223778160254 6.40839798164597e-12 NA NA NA hsa-miR-146b-5p KLF12 2.23105707690238 3.83997814011313e-23 -0.391196935968631 0.0893097621844466 PITA -0.125440358562548 0.0293364850080732 NA NA NA hsa-miR-194-5p KLF12 2.24386881692218 9.35116329002209e-11 -0.391196935968631 0.0893097621844466 MirTarget -0.257707266483337 7.81851492942708e-12 NA NA NA hsa-miR-200a-3p KLF12 2.02394729844446 2.21240501925011e-08 -0.391196935968631 0.0893097621844466 MirTarget -0.265088705552916 2.3615233137417e-13 NA NA NA hsa-miR-200a-5p KLF12 2.19152245759943 3.17968183522514e-11 -0.391196935968631 0.0893097621844466 mirMAP -0.286964722620497 2.53263253933934e-13 NA NA NA hsa-miR-200b-3p KLF12 2.06025765178663 3.07718049337497e-10 -0.391196935968631 0.0893097621844466 TargetScan -0.272547645001692 9.32948646906076e-12 NA NA NA hsa-miR-21-5p KLF12 2.21515015440792 6.0468197386674e-49 -0.391196935968631 0.0893097621844466 mirMAP -0.223778235785237 0.00419931518753078 NA NA NA hsa-miR-335-3p KLF12 2.29463721765513 4.1956113745077e-18 -0.391196935968631 0.0893097621844466 mirMAP -0.21466964133432 1.30124119850375e-05 NA NA NA hsa-miR-194-5p KLF15 2.24386881692218 9.35116329002209e-11 -2.91216972622779 7.49011591918797e-11 miRNATAP -0.474469604121401 5.83510984955025e-10 NA NA NA hsa-miR-335-3p KLF15 2.29463721765513 4.1956113745077e-18 -2.91216972622779 7.49011591918797e-11 mirMAP -0.787415268581038 1.02914346644059e-16 NA NA NA hsa-miR-135b-5p KLF4 2.80066701698235 2.12546333413447e-11 -1.88610674592481 2.42476920274834e-18 miRNAWalker2_validate;MirTarget -0.121006765598959 0.000337857966070833 NA NA NA hsa-miR-146b-5p KLF7 2.23105707690238 3.83997814011313e-23 -0.384800208713289 0.0487443338946401 PITA;miRanda;miRNATAP -0.269849026611546 1.43162955126495e-08 NA NA NA hsa-miR-194-5p KLF7 2.24386881692218 9.35116329002209e-11 -0.384800208713289 0.0487443338946401 miRNATAP -0.160339486214324 8.97481906594612e-07 NA NA NA hsa-miR-200a-5p KLF7 2.19152245759943 3.17968183522514e-11 -0.384800208713289 0.0487443338946401 miRNATAP -0.225377617634865 1.79297433657213e-11 NA NA NA hsa-miR-21-5p KLF7 2.21515015440792 6.0468197386674e-49 -0.384800208713289 0.0487443338946401 mirMAP -0.344219380126937 1.23492626577369e-07 NA NA NA hsa-miR-335-3p KLF7 2.29463721765513 4.1956113745077e-18 -0.384800208713289 0.0487443338946401 mirMAP -0.227707994617304 3.59529656407388e-08 NA NA NA hsa-miR-146b-5p KLF8 2.23105707690238 3.83997814011313e-23 -1.20139105028068 1.9297956441475e-06 miRanda -0.359651371910629 9.22704547805688e-09 NA NA NA hsa-miR-200a-5p KLF9 2.19152245759943 3.17968183522514e-11 -1.42972938246189 7.62390409996413e-11 MirTarget;miRNATAP -0.404755616111305 1.24794838283583e-28 NA NA NA hsa-miR-200b-3p KLF9 2.06025765178663 3.07718049337497e-10 -1.42972938246189 7.62390409996413e-11 TargetScan -0.398076308422641 1.07736995687844e-26 NA NA NA hsa-miR-21-5p KLF9 2.21515015440792 6.0468197386674e-49 -1.42972938246189 7.62390409996413e-11 miRNAWalker2_validate -0.641653819250471 8.8137342133806e-19 NA NA NA hsa-miR-335-3p KLF9 2.29463721765513 4.1956113745077e-18 -1.42972938246189 7.62390409996413e-11 mirMAP -0.444575454742445 1.26999769421962e-22 NA NA NA hsa-miR-200b-3p KLHDC1 2.06025765178663 3.07718049337497e-10 -0.906809773375172 2.15955945263258e-06 MirTarget -0.285383221019472 4.81011246609609e-18 NA NA NA hsa-miR-146b-3p KLHDC8B 2.08650140817622 5.3293570720033e-22 -0.829214497649129 1.56042718520463e-06 MirTarget;PITA;miRNATAP -0.229284216125248 3.61378261441303e-07 NA NA NA hsa-miR-335-3p KLHL13 2.29463721765513 4.1956113745077e-18 -1.3770842091274 0.000124393191665568 MirTarget -0.367874004827599 2.00706282598105e-06 NA NA NA hsa-miR-200b-3p KLHL14 2.06025765178663 3.07718049337497e-10 -0.843682974908397 0.0541217730637787 TargetScan -0.203593499575582 0.010062796174042 NA NA NA hsa-miR-18a-5p KLHL15 2.04701000113742 1.30593450319289e-12 -0.362737945993933 0.012962856301377 miRNATAP -0.127911591703074 1.24705394301925e-05 NA NA NA hsa-miR-192-5p KLHL15 2.0867723747501 3.57854249239079e-08 -0.362737945993933 0.012962856301377 miRNAWalker2_validate -0.13099959220988 4.58597189241853e-09 NA NA NA hsa-miR-21-5p KLHL15 2.21515015440792 6.0468197386674e-49 -0.362737945993933 0.012962856301377 miRNAWalker2_validate;miRNATAP -0.271943218699736 2.12204817076348e-08 NA NA NA hsa-miR-335-3p KLHL15 2.29463721765513 4.1956113745077e-18 -0.362737945993933 0.012962856301377 mirMAP -0.116226611803591 0.000215347949163047 NA NA NA hsa-miR-146b-3p KLHL21 2.08650140817622 5.3293570720033e-22 -0.0975845665313919 0.477450242980798 MirTarget -0.157835664531355 7.52373476716552e-06 NA NA NA hsa-miR-18a-5p KLHL21 2.04701000113742 1.30593450319289e-12 -0.0975845665313919 0.477450242980798 mirMAP -0.191273345467382 6.00804969516551e-13 NA NA NA hsa-miR-192-5p KLHL21 2.0867723747501 3.57854249239079e-08 -0.0975845665313919 0.477450242980798 mirMAP -0.198941840932597 4.27290827757677e-24 NA NA NA hsa-miR-146b-5p KLHL29 2.23105707690238 3.83997814011313e-23 0.269975851414258 0.215651636043213 miRanda -0.247767292797865 3.77870434680309e-06 NA NA NA hsa-miR-200b-3p KLHL29 2.06025765178663 3.07718049337497e-10 0.269975851414258 0.215651636043213 MirTarget -0.285849859135558 2.10869790208177e-14 NA NA NA hsa-miR-183-5p KLHL3 2.08412478942637 1.08931431254487e-10 -0.578181441034985 0.00374713642224286 miRNATAP -0.242171235791279 5.85752946284686e-12 NA NA NA hsa-miR-200b-3p KLHL3 2.06025765178663 3.07718049337497e-10 -0.578181441034985 0.00374713642224286 TargetScan;mirMAP -0.165632854987737 3.31663386635626e-06 NA NA NA hsa-miR-935 KLHL30 2.321600496365 1.00042201726114e-07 -0.876205427287191 0.002872369962136 mirMAP -0.221842913535087 1.14091111265017e-07 NA NA NA hsa-miR-146b-5p KLHL4 2.23105707690238 3.83997814011313e-23 -0.605621035233264 0.0620654301942442 miRanda -0.317684015929499 7.81712561610355e-05 NA NA NA hsa-miR-21-5p KLHL4 2.21515015440792 6.0468197386674e-49 -0.605621035233264 0.0620654301942442 mirMAP -0.393575407519028 0.000339819150686867 NA NA NA hsa-miR-335-3p KLHL4 2.29463721765513 4.1956113745077e-18 -0.605621035233264 0.0620654301942442 mirMAP -0.427765793225189 3.53356257138647e-10 NA NA NA hsa-miR-335-3p KLRC1 2.29463721765513 4.1956113745077e-18 -0.673638976168201 0.0269576373508567 mirMAP -0.158372905831766 0.0165868506694278 NA NA NA hsa-miR-135b-5p KNDC1 2.80066701698235 2.12546333413447e-11 -0.487248051918295 0.245986771859154 mirMAP -0.176331533853671 0.00420990875852072 NA NA NA hsa-miR-192-5p KPNA5 2.0867723747501 3.57854249239079e-08 -0.275081759540677 0.0683152031438195 miRNAWalker2_validate -0.178003032452795 2.18239408032147e-15 NA NA NA hsa-miR-335-3p KPNA5 2.29463721765513 4.1956113745077e-18 -0.275081759540677 0.0683152031438195 mirMAP -0.123920452650208 0.000128302428058462 NA NA NA hsa-miR-1-3p KRAS -2.73171785118192 3.4424534921136e-12 0.300368703208351 0.110791911795054 MirTarget -0.115915277384752 2.92146944379482e-05 NA NA NA hsa-miR-146b-5p KRCC1 2.23105707690238 3.83997814011313e-23 -0.792453624975451 8.61137649542405e-08 miRanda -0.156240417008397 2.93770627128053e-05 NA NA NA hsa-miR-146b-5p KREMEN1 2.23105707690238 3.83997814011313e-23 -0.26187872872101 0.226853924782333 miRanda -0.14384755029951 0.0077015311860805 NA NA NA hsa-miR-146b-5p KRT1 2.23105707690238 3.83997814011313e-23 -2.55981640071622 5.09405169031182e-06 miRanda -0.598013353566684 2.25234088667618e-05 NA NA NA hsa-miR-200a-3p KSR1 2.02394729844446 2.21240501925011e-08 -0.0935264477686886 0.500996355091324 mirMAP -0.10575166170484 2.30351895347991e-06 NA NA NA hsa-miR-200b-3p KSR1 2.06025765178663 3.07718049337497e-10 -0.0935264477686886 0.500996355091324 TargetScan;mirMAP -0.113193568873583 4.18392451843884e-06 NA NA NA hsa-miR-146b-5p LAMA2 2.23105707690238 3.83997814011313e-23 -0.817286054002912 0.00263248830630044 miRanda -0.297529914934852 1.01900713127117e-05 NA NA NA hsa-miR-21-5p LAMA4 2.21515015440792 6.0468197386674e-49 0.109863670029437 0.552070038635586 MirTarget -0.179609460137434 0.00406941782343354 NA NA NA hsa-miR-146b-5p LAMC1 2.23105707690238 3.83997814011313e-23 0.370285667657678 0.0366283240859651 miRanda -0.18146276886274 3.4354268406317e-05 NA NA NA hsa-miR-200b-3p LAMC1 2.06025765178663 3.07718049337497e-10 0.370285667657678 0.0366283240859651 MirTarget;TargetScan -0.246259940243578 3.71481628992343e-16 NA NA NA hsa-miR-192-5p LANCL3 2.0867723747501 3.57854249239079e-08 -1.8796499241064 4.17461140342492e-10 mirMAP -0.239565751576541 6.13898434572987e-07 NA NA NA hsa-miR-21-5p LANCL3 2.21515015440792 6.0468197386674e-49 -1.8796499241064 4.17461140342492e-10 MirTarget -0.742632923111862 2.29531364118564e-13 NA NA NA hsa-miR-335-3p LANCL3 2.29463721765513 4.1956113745077e-18 -1.8796499241064 4.17461140342492e-10 mirMAP -0.415151664683946 2.00344514117725e-10 NA NA NA hsa-miR-141-5p LAPTM4A 2.13747696823946 1.73124674554872e-11 -0.203706498715671 0.021414970758639 MirTarget -0.100240043895613 2.0256120693547e-10 NA NA NA hsa-miR-1-3p LARP4 -2.73171785118192 3.4424534921136e-12 0.410432316370399 0.000134132263689673 miRTarBase;MirTarget -0.109980684985604 1.11021174598878e-12 NA NA NA hsa-miR-146b-5p LARP6 2.23105707690238 3.83997814011313e-23 -1.21518137059255 1.15860290911023e-05 miRanda -0.534352418414487 1.01233189474878e-15 NA NA NA hsa-miR-200b-3p LATS2 2.06025765178663 3.07718049337497e-10 0.159417049044428 0.23040279833664 TargetScan -0.190742258618125 1.98138601494745e-17 NA NA NA hsa-miR-146b-5p LAYN 2.23105707690238 3.83997814011313e-23 -0.706342717621403 0.00316553384797005 miRanda -0.327984829597612 2.30152248060493e-08 NA NA NA hsa-miR-18a-5p LBH 2.04701000113742 1.30593450319289e-12 0.756142642150839 1.78102692350956e-05 mirMAP -0.102586056618695 0.00455758493914597 NA NA NA hsa-miR-200b-3p LCA5 2.06025765178663 3.07718049337497e-10 0.344794733894058 0.0481852760843641 MirTarget;TargetScan -0.17875475624585 5.519638403367e-09 NA NA NA hsa-miR-146b-5p LDB3 2.23105707690238 3.83997814011313e-23 -2.58310823002651 2.72573335948268e-08 miRanda -1.03185157542426 1.1203238703716e-20 NA NA NA hsa-miR-146b-5p LDLRAD3 2.23105707690238 3.83997814011313e-23 0.049853493651828 0.80723396925735 miRanda -0.151525232611042 0.00281901388136515 NA NA NA hsa-miR-192-5p LEFTY2 2.0867723747501 3.57854249239079e-08 -0.549828355218265 0.210374338730888 MirTarget -0.229152069919935 0.000834800400736052 NA NA NA hsa-miR-146b-5p LEPR 2.23105707690238 3.83997814011313e-23 -0.930433638820431 9.03033126875146e-06 miRanda -0.309332034503107 2.18149856872288e-09 NA NA NA hsa-miR-335-3p LEPR 2.29463721765513 4.1956113745077e-18 -0.930433638820431 9.03033126875146e-06 mirMAP -0.368888822138726 1.67914889526691e-17 NA NA NA hsa-miR-335-3p LEPROT 2.29463721765513 4.1956113745077e-18 -0.315730025278079 0.000278682729289365 mirMAP -0.129979005983847 5.95853583322241e-13 NA NA NA hsa-miR-194-5p LGI1 2.24386881692218 9.35116329002209e-11 -4.10700415837875 6.17715161417026e-15 MirTarget;miRNATAP -0.624129111937526 6.81775872828373e-12 NA NA NA hsa-miR-935 LGI1 2.321600496365 1.00042201726114e-07 -4.10700415837875 6.17715161417026e-15 MirTarget;PITA;miRNATAP -0.715397632767907 4.85870671926485e-22 NA NA NA hsa-miR-21-5p LGI2 2.21515015440792 6.0468197386674e-49 0.311134617736179 0.311864358009923 mirMAP -0.273782506669441 0.00876708165597393 NA NA NA hsa-miR-335-3p LGI2 2.29463721765513 4.1956113745077e-18 0.311134617736179 0.311864358009923 mirMAP -0.243189591333339 0.000231637486627035 NA NA NA hsa-miR-200b-3p LGSN 2.06025765178663 3.07718049337497e-10 -0.582810994178186 0.339927226652801 MirTarget -0.359302445645014 0.00104204326168528 NA NA NA hsa-miR-335-3p LGSN 2.29463721765513 4.1956113745077e-18 -0.582810994178186 0.339927226652801 mirMAP -0.323976012279798 0.0142011047926452 NA NA NA hsa-miR-146b-5p LHFP 2.23105707690238 3.83997814011313e-23 -0.16725244890427 0.413709309444094 miRanda -0.203782040108938 5.42022319802671e-05 NA NA NA hsa-miR-192-5p LHFP 2.0867723747501 3.57854249239079e-08 -0.16725244890427 0.413709309444094 miRNAWalker2_validate -0.251851259659309 7.83967038097141e-17 NA NA NA hsa-miR-200a-3p LHFP 2.02394729844446 2.21240501925011e-08 -0.16725244890427 0.413709309444094 MirTarget -0.311504206908658 3.10889505612169e-24 NA NA NA hsa-miR-200b-3p LHFP 2.06025765178663 3.07718049337497e-10 -0.16725244890427 0.413709309444094 MirTarget;TargetScan -0.325780711159206 9.92212710368773e-22 NA NA NA hsa-miR-183-5p LHFPL2 2.08412478942637 1.08931431254487e-10 0.208635654258304 0.136288343235 MirTarget -0.124393383569142 6.75241689179296e-07 NA NA NA hsa-miR-192-5p LHFPL4 2.0867723747501 3.57854249239079e-08 -1.81431715801582 3.68825383401522e-05 miRNAWalker2_validate -0.292303859222491 2.44737387383583e-05 NA NA NA hsa-miR-194-5p LHX6 2.24386881692218 9.35116329002209e-11 -0.0865769869427766 0.69192866172122 miRNATAP -0.136030273752344 0.000215816137231916 NA NA NA hsa-miR-200a-3p LHX6 2.02394729844446 2.21240501925011e-08 -0.0865769869427766 0.69192866172122 MirTarget;miRNATAP -0.220786572495389 1.88748704951827e-10 NA NA NA hsa-miR-21-5p LIFR 2.21515015440792 6.0468197386674e-49 -1.79354293269512 5.04936245466941e-09 miRNAWalker2_validate -0.675845199596711 7.93687305848831e-11 NA NA NA hsa-miR-335-3p LIFR 2.29463721765513 4.1956113745077e-18 -1.79354293269512 5.04936245466941e-09 MirTarget -0.505348502173051 7.97523185994442e-15 NA NA NA hsa-miR-935 LIFR 2.321600496365 1.00042201726114e-07 -1.79354293269512 5.04936245466941e-09 PITA -0.230314875694708 2.71330344104014e-07 NA NA NA hsa-miR-146b-5p LIMCH1 2.23105707690238 3.83997814011313e-23 -0.915408206659925 5.81579486964095e-06 miRanda -0.316559537223063 1.7674562389196e-10 NA NA NA hsa-miR-192-5p LIMCH1 2.0867723747501 3.57854249239079e-08 -0.915408206659925 5.81579486964095e-06 miRNAWalker2_validate -0.18357428097274 4.97741621944863e-09 NA NA NA hsa-miR-194-5p LIMCH1 2.24386881692218 9.35116329002209e-11 -0.915408206659925 5.81579486964095e-06 MirTarget -0.169824239745119 7.27029968606177e-07 NA NA NA hsa-miR-200a-3p LIMCH1 2.02394729844446 2.21240501925011e-08 -0.915408206659925 5.81579486964095e-06 MirTarget -0.195343322569173 2.59681727703063e-09 NA NA NA hsa-miR-200a-5p LIMCH1 2.19152245759943 3.17968183522514e-11 -0.915408206659925 5.81579486964095e-06 MirTarget -0.237536133334386 1.53870834049805e-11 NA NA NA hsa-miR-21-5p LIMCH1 2.21515015440792 6.0468197386674e-49 -0.915408206659925 5.81579486964095e-06 miRNAWalker2_validate -0.404741372457521 2.52998047781006e-09 NA NA NA hsa-miR-335-3p LIN7A 2.29463721765513 4.1956113745077e-18 0.0189988898876393 0.939674680376874 mirMAP -0.140603857549947 0.00945002382965526 NA NA NA hsa-miR-200b-3p LIN7B 2.06025765178663 3.07718049337497e-10 -1.02527483051279 9.39783974005987e-13 TargetScan -0.138151447160607 1.86096234634516e-07 NA NA NA hsa-miR-935 LIX1 2.321600496365 1.00042201726114e-07 -1.74977888676265 0.000312295693158422 MirTarget -0.47873555081548 1.95463379324929e-12 NA NA NA hsa-miR-196a-5p LIX1L 5.05945965885472 4.48343841468539e-25 -0.431018566376487 0.0306721981483488 MirTarget -0.133267621378852 2.69636188286267e-09 NA NA NA hsa-miR-196b-5p LIX1L 4.51951031652328 7.04026169031626e-18 -0.431018566376487 0.0306721981483488 MirTarget -0.138357558282307 4.2120973478523e-11 NA NA NA hsa-miR-200b-3p LIX1L 2.06025765178663 3.07718049337497e-10 -0.431018566376487 0.0306721981483488 MirTarget -0.340719964763678 2.78516810240192e-25 NA NA NA hsa-miR-935 LMO2 2.321600496365 1.00042201726114e-07 -0.581887842718007 0.000157088578830384 MirTarget;PITA;miRNATAP -0.139823679580916 1.18024261461019e-10 NA NA NA hsa-miR-183-5p LMO3 2.08412478942637 1.08931431254487e-10 -1.45602321679724 0.00074981084459688 miRNATAP -0.833449202398475 2.53044095303307e-32 NA NA NA hsa-miR-200a-3p LMO3 2.02394729844446 2.21240501925011e-08 -1.45602321679724 0.00074981084459688 MirTarget -0.682326119252419 1.0596340195842e-25 NA NA NA hsa-miR-335-3p LMO3 2.29463721765513 4.1956113745077e-18 -1.45602321679724 0.00074981084459688 mirMAP -0.577510354956831 2.6412481451055e-10 NA NA NA hsa-miR-335-3p LMO4 2.29463721765513 4.1956113745077e-18 -0.338684355839769 0.0874599861843522 MirTarget -0.142769431550151 0.000821550177222402 NA NA NA hsa-miR-200a-3p LMOD3 2.02394729844446 2.21240501925011e-08 -0.613388114815795 0.0636660868690428 miRNATAP -0.388565186582068 7.28828074018062e-14 NA NA NA hsa-miR-335-3p LMOD3 2.29463721765513 4.1956113745077e-18 -0.613388114815795 0.0636660868690428 mirMAP -0.399112445202928 1.14346590880983e-08 NA NA NA hsa-miR-146b-5p LNPEP 2.23105707690238 3.83997814011313e-23 -0.183460285445965 0.249607079639139 miRanda -0.105688792862937 0.00766666214199834 NA NA NA hsa-miR-194-5p LNPEP 2.24386881692218 9.35116329002209e-11 -0.183460285445965 0.249607079639139 mirMAP -0.136417126555646 2.60033353978134e-07 NA NA NA hsa-miR-200b-3p LNPEP 2.06025765178663 3.07718049337497e-10 -0.183460285445965 0.249607079639139 mirMAP -0.155332242004559 2.88276996012345e-08 NA NA NA hsa-miR-21-5p LNPEP 2.21515015440792 6.0468197386674e-49 -0.183460285445965 0.249607079639139 mirMAP -0.12256577570035 0.0234718180225698 NA NA NA hsa-miR-135b-5p LONRF2 2.80066701698235 2.12546333413447e-11 -2.03899615797417 9.63293546267136e-06 mirMAP -0.401208870290829 2.12419233228315e-09 NA NA NA hsa-miR-141-5p LONRF2 2.13747696823946 1.73124674554872e-11 -2.03899615797417 9.63293546267136e-06 mirMAP -0.765109388808891 1.21033039806807e-21 NA NA NA hsa-miR-146b-5p LONRF2 2.23105707690238 3.83997814011313e-23 -2.03899615797417 9.63293546267136e-06 mirMAP -0.94501474177043 7.76256737982551e-18 NA NA NA hsa-miR-183-5p LONRF2 2.08412478942637 1.08931431254487e-10 -2.03899615797417 9.63293546267136e-06 mirMAP -0.807690539227293 3.39540256275873e-25 NA NA NA hsa-miR-18a-5p LONRF2 2.04701000113742 1.30593450319289e-12 -2.03899615797417 9.63293546267136e-06 mirMAP -0.836640251522395 1.72081691408489e-21 NA NA NA hsa-miR-200a-5p LONRF2 2.19152245759943 3.17968183522514e-11 -2.03899615797417 9.63293546267136e-06 mirMAP -0.7023777801954 1.73543243487158e-19 NA NA NA hsa-miR-21-5p LONRF2 2.21515015440792 6.0468197386674e-49 -2.03899615797417 9.63293546267136e-06 miRNAWalker2_validate -1.03389767928222 1.6990485428945e-11 NA NA NA hsa-miR-335-3p LONRF2 2.29463721765513 4.1956113745077e-18 -2.03899615797417 9.63293546267136e-06 mirMAP -0.798111252170693 6.90367941327748e-17 NA NA NA hsa-miR-92a-1-5p LONRF2 2.04820501765632 9.32117486799495e-13 -2.03899615797417 9.63293546267136e-06 mirMAP -0.691931812906642 1.01283641434611e-13 NA NA NA hsa-miR-935 LONRF2 2.321600496365 1.00042201726114e-07 -2.03899615797417 9.63293546267136e-06 mirMAP -0.485280054482405 5.58666138202136e-14 NA NA NA hsa-miR-200b-3p LPAR1 2.06025765178663 3.07718049337497e-10 -1.56606812793793 2.0874874683954e-10 MirTarget;TargetScan -0.352326937227282 6.08851543911358e-16 NA NA NA hsa-miR-335-3p LPAR1 2.29463721765513 4.1956113745077e-18 -1.56606812793793 2.0874874683954e-10 mirMAP -0.453010512699217 2.09486958109304e-18 NA NA NA hsa-miR-200a-3p LPAR3 2.02394729844446 2.21240501925011e-08 -2.42785662189318 2.89235623996199e-08 MirTarget -0.25535257436036 0.000508112895999835 NA NA NA hsa-miR-192-5p LPAR4 2.0867723747501 3.57854249239079e-08 0.253887996571817 0.360126186136074 MirTarget;miRNATAP -0.357292664266111 1.77337975673895e-18 NA NA NA hsa-miR-200b-3p LPIN1 2.06025765178663 3.07718049337497e-10 -0.293587483978061 0.0393942939219579 MirTarget;TargetScan -0.118037779532526 3.0861648199128e-06 NA NA NA hsa-miR-146b-5p LPP 2.23105707690238 3.83997814011313e-23 -0.458891651324375 0.0447471835132921 miRanda -0.348349140462415 3.19247683650421e-10 NA NA NA hsa-miR-18a-5p LPP 2.04701000113742 1.30593450319289e-12 -0.458891651324375 0.0447471835132921 mirMAP -0.442467833101278 1.00573728578748e-25 NA NA NA hsa-miR-192-5p LPP 2.0867723747501 3.57854249239079e-08 -0.458891651324375 0.0447471835132921 mirMAP -0.316580153062267 1.68198159403058e-21 NA NA NA hsa-miR-194-5p LPP 2.24386881692218 9.35116329002209e-11 -0.458891651324375 0.0447471835132921 mirMAP -0.276246852783127 1.04213003074328e-13 NA NA NA hsa-miR-196a-5p LPP 5.05945965885472 4.48343841468539e-25 -0.458891651324375 0.0447471835132921 mirMAP -0.170192139887249 2.3054614778676e-11 NA NA NA hsa-miR-196b-5p LPP 4.51951031652328 7.04026169031626e-18 -0.458891651324375 0.0447471835132921 mirMAP -0.189882042667813 7.99948923201177e-16 NA NA NA hsa-miR-200a-3p LPP 2.02394729844446 2.21240501925011e-08 -0.458891651324375 0.0447471835132921 miRNATAP -0.370010224813908 1.02356892818588e-27 NA NA NA hsa-miR-21-5p LPP 2.21515015440792 6.0468197386674e-49 -0.458891651324375 0.0447471835132921 mirMAP -0.328154817536089 2.01705104586128e-05 NA NA NA hsa-miR-335-3p LPP 2.29463721765513 4.1956113745077e-18 -0.458891651324375 0.0447471835132921 mirMAP -0.330618843007247 3.89676032816313e-12 NA NA NA hsa-miR-935 LPP 2.321600496365 1.00042201726114e-07 -0.458891651324375 0.0447471835132921 PITA;mirMAP;miRNATAP -0.222572091552951 2.38719559385348e-12 NA NA NA hsa-miR-200b-3p LRAT 2.06025765178663 3.07718049337497e-10 -3.20129901307276 1.87481613009717e-10 MirTarget -0.559606646467151 8.52337531586293e-10 NA NA NA hsa-miR-335-3p LRAT 2.29463721765513 4.1956113745077e-18 -3.20129901307276 1.87481613009717e-10 MirTarget;mirMAP -0.502129968890498 6.40146732674214e-06 NA NA NA hsa-miR-194-5p LRCH2 2.24386881692218 9.35116329002209e-11 -0.75858565247788 0.00191248560209684 MirTarget -0.355779755333416 6.16699675584549e-20 NA NA NA hsa-miR-146b-5p LRFN5 2.23105707690238 3.83997814011313e-23 -1.48275618922798 1.55944946207763e-06 miRanda -0.427246363724952 2.63518433369614e-08 NA NA NA hsa-miR-192-5p LRIG1 2.0867723747501 3.57854249239079e-08 -0.5374742879248 0.00587721628379153 miRNAWalker2_validate -0.126154667074504 3.41125117205796e-05 NA NA NA hsa-miR-200b-3p LRIG1 2.06025765178663 3.07718049337497e-10 -0.5374742879248 0.00587721628379153 TargetScan -0.237917177126363 2.35859157567259e-12 NA NA NA hsa-miR-200b-3p LRP1 2.06025765178663 3.07718049337497e-10 0.0907573600866467 0.623201963667416 TargetScan -0.189915376663552 4.25212126250088e-09 NA NA NA hsa-miR-146b-5p LRP10 2.23105707690238 3.83997814011313e-23 -0.718552106392158 1.59689403448718e-08 miRanda -0.132282676572495 3.99933044598552e-05 NA NA NA hsa-miR-18a-5p LRP10 2.04701000113742 1.30593450319289e-12 -0.718552106392158 1.59689403448718e-08 mirMAP -0.100366683033626 0.00012833992337916 NA NA NA hsa-miR-335-3p LRP12 2.29463721765513 4.1956113745077e-18 0.188515819527515 0.254029924860792 MirTarget -0.13993259827883 7.56840110881137e-05 NA NA NA hsa-miR-183-5p LRP1B 2.08412478942637 1.08931431254487e-10 -2.16345659630435 6.96966627503369e-08 miRNATAP -0.606236650404861 8.18353266679789e-18 NA NA NA hsa-miR-196a-5p LRP1B 5.05945965885472 4.48343841468539e-25 -2.16345659630435 6.96966627503369e-08 miRNATAP -0.272285697801433 3.78407755228171e-09 NA NA NA hsa-miR-196b-5p LRP1B 4.51951031652328 7.04026169031626e-18 -2.16345659630435 6.96966627503369e-08 miRNATAP -0.303953179703063 1.5155770762449e-12 NA NA NA hsa-miR-200b-3p LRP1B 2.06025765178663 3.07718049337497e-10 -2.16345659630435 6.96966627503369e-08 MirTarget;TargetScan -0.5224621159595 1.80558403475425e-13 NA NA NA hsa-miR-335-3p LRP1B 2.29463721765513 4.1956113745077e-18 -2.16345659630435 6.96966627503369e-08 MirTarget;mirMAP -0.535669839391253 5.72787557545587e-10 NA NA NA hsa-miR-335-3p LRP2BP 2.29463721765513 4.1956113745077e-18 -0.118698129000738 0.494818685233906 mirMAP -0.147570405232319 7.19412447726639e-05 NA NA NA hsa-miR-192-5p LRRC10B 2.0867723747501 3.57854249239079e-08 -1.29310722936696 0.00054997844187855 MirTarget -0.44602540475829 2.25677766232011e-15 NA NA NA hsa-miR-196a-5p LRRC17 5.05945965885472 4.48343841468539e-25 -0.751461682640834 0.00664664297258751 MirTarget;miRNATAP -0.140558878217394 9.06588092244379e-06 NA NA NA hsa-miR-196b-5p LRRC17 4.51951031652328 7.04026169031626e-18 -0.751461682640834 0.00664664297258751 MirTarget;miRNATAP -0.124495964897592 3.21734810133442e-05 NA NA NA hsa-miR-146b-5p LRRC29 2.23105707690238 3.83997814011313e-23 -0.458381429649462 0.00204904294421374 miRanda -0.146013250956872 7.78458734115519e-05 NA NA NA hsa-miR-141-5p LRRC4 2.13747696823946 1.73124674554872e-11 -1.77387801463651 4.24132802666276e-15 miRNATAP -0.374727461364056 7.45619117323388e-20 NA NA NA hsa-miR-196a-5p LRRC4B 5.05945965885472 4.48343841468539e-25 -0.516476957637773 0.0182054548772724 MirTarget -0.103538060598486 3.50303306296135e-05 NA NA NA hsa-miR-196b-5p LRRC4B 4.51951031652328 7.04026169031626e-18 -0.516476957637773 0.0182054548772724 MirTarget -0.136986565425433 3.62864304299166e-09 NA NA NA hsa-miR-935 LRRC55 2.321600496365 1.00042201726114e-07 -0.0257303322064353 0.931629458622402 MirTarget;miRNATAP -0.19293132796866 6.04025261806915e-06 NA NA NA hsa-miR-1-3p LRRC59 -2.73171785118192 3.4424534921136e-12 0.365224945757983 0.00145209629472601 MirTarget -0.120780561109673 1.66374828321565e-13 NA NA NA hsa-miR-146b-5p LRRC7 2.23105707690238 3.83997814011313e-23 -1.34133723141535 0.0119253573751723 miRanda -0.66627723354305 3.91802082908426e-07 NA NA NA hsa-miR-935 LRRC7 2.321600496365 1.00042201726114e-07 -1.34133723141535 0.0119253573751723 PITA -0.491993111690237 4.57868162564467e-11 NA NA NA hsa-miR-335-3p LRRC8C 2.29463721765513 4.1956113745077e-18 0.211614278241733 0.126207579285338 MirTarget;mirMAP -0.10384847418901 0.000470354709275992 NA NA NA hsa-miR-146b-5p LRRIQ1 2.23105707690238 3.83997814011313e-23 -1.16676840777899 0.0138348413554937 miRanda -0.551222547378092 2.48690409314495e-06 NA NA NA hsa-miR-135b-5p LRRN1 2.80066701698235 2.12546333413447e-11 -0.430095602213544 0.394795048637996 MirTarget -0.164579056413124 0.0268441576760732 NA NA NA hsa-miR-146b-5p LRRN2 2.23105707690238 3.83997814011313e-23 -0.247448447258567 0.429978363292373 miRanda -0.170596558460549 0.0292986116928251 NA NA NA hsa-miR-935 LRRN3 2.321600496365 1.00042201726114e-07 -0.39264287572501 0.162925453177655 PITA;miRNATAP -0.142019816332569 0.000436793543663326 NA NA NA hsa-miR-146b-5p LRRTM2 2.23105707690238 3.83997814011313e-23 -0.311151130193272 0.0955306944055494 PITA;miRanda -0.114686150752328 0.0138047453972292 NA NA NA hsa-miR-200a-3p LRRTM2 2.02394729844446 2.21240501925011e-08 -0.311151130193272 0.0955306944055494 miRNATAP -0.131380312040809 1.42841927968191e-05 NA NA NA hsa-miR-146b-5p LRTOMT 2.23105707690238 3.83997814011313e-23 -0.444240356106936 1.14121069262933e-06 miRanda -0.107235560027196 2.40466705920309e-06 NA NA NA hsa-miR-192-5p LSAMP 2.0867723747501 3.57854249239079e-08 -0.0662545207493661 0.817079476535713 MirTarget -0.238173594716346 5.81778868969382e-08 NA NA NA hsa-miR-200a-3p LTBP1 2.02394729844446 2.21240501925011e-08 -0.111820928845358 0.618088831140749 MirTarget -0.364286632535366 3.34855467796136e-28 NA NA NA hsa-miR-335-3p LUZP2 2.29463721765513 4.1956113745077e-18 -0.0562983646933786 0.894163266670475 mirMAP -0.194666596226156 0.0335362889022316 NA NA NA hsa-miR-92a-1-5p LUZP2 2.04820501765632 9.32117486799495e-13 -0.0562983646933786 0.894163266670475 MirTarget -0.405075188738071 2.83314615648107e-06 NA NA NA hsa-miR-141-5p LYNX1 2.13747696823946 1.73124674554872e-11 -1.99541123631618 3.0993536139299e-07 mirMAP -0.561027824459617 9.45018858819978e-16 NA NA NA hsa-miR-192-5p LYRM7 2.0867723747501 3.57854249239079e-08 -0.403426800928447 0.000748648565531885 miRNAWalker2_validate -0.107604610205898 4.81295477986129e-09 NA NA NA hsa-miR-21-5p LYRM7 2.21515015440792 6.0468197386674e-49 -0.403426800928447 0.000748648565531885 miRNAWalker2_validate -0.125290875722158 0.00211275336479156 NA NA NA hsa-miR-335-3p LYST 2.29463721765513 4.1956113745077e-18 -0.30754875248622 0.0119875206292908 mirMAP -0.162534170228423 2.38925693795185e-10 NA NA NA hsa-miR-335-3p MAB21L1 2.29463721765513 4.1956113745077e-18 -2.60154888156958 3.00599199281732e-11 mirMAP -0.681566523907247 2.74486478483791e-16 NA NA NA hsa-miR-146b-5p MAB21L2 2.23105707690238 3.83997814011313e-23 -1.89685123662474 1.54311971717598e-05 miRanda;miRNATAP -0.769065037616806 5.560792585178e-13 NA NA NA hsa-miR-192-5p MACF1 2.0867723747501 3.57854249239079e-08 0.0187245853067326 0.903346275968091 miRNAWalker2_validate;miRNATAP -0.202678689636768 2.01074555597497e-19 NA NA NA hsa-miR-335-3p MACF1 2.29463721765513 4.1956113745077e-18 0.0187245853067326 0.903346275968091 mirMAP -0.178738950406329 3.7501421125713e-08 NA NA NA hsa-miR-141-5p MACROD2 2.13747696823946 1.73124674554872e-11 -0.15219427771534 0.639394953915592 mirMAP -0.184025980850332 0.00206836887558443 NA NA NA hsa-miR-183-5p MACROD2 2.08412478942637 1.08931431254487e-10 -0.15219427771534 0.639394953915592 MirTarget -0.23166324321314 7.77729004160936e-05 NA NA NA hsa-miR-194-5p MAF 2.24386881692218 9.35116329002209e-11 -1.25672430426217 1.95182535429058e-12 miRNATAP -0.175756876789981 1.28104101046022e-08 NA NA NA hsa-miR-200a-3p MAF 2.02394729844446 2.21240501925011e-08 -1.25672430426217 1.95182535429058e-12 miRNATAP -0.21019043832689 7.94327589349086e-13 NA NA NA hsa-miR-200a-5p MAF 2.19152245759943 3.17968183522514e-11 -1.25672430426217 1.95182535429058e-12 miRNATAP -0.229990959080293 4.54139187247851e-13 NA NA NA hsa-miR-200b-3p MAF 2.06025765178663 3.07718049337497e-10 -1.25672430426217 1.95182535429058e-12 TargetScan -0.232442602107388 5.17049196553262e-13 NA NA NA hsa-miR-335-3p MAF 2.29463721765513 4.1956113745077e-18 -1.25672430426217 1.95182535429058e-12 mirMAP -0.252465521470231 9.64531349664642e-11 NA NA NA hsa-miR-135b-5p MAFB 2.80066701698235 2.12546333413447e-11 -0.0233819798952197 0.898645258592483 miRNAWalker2_validate -0.126983393779143 1.61894731443194e-06 NA NA NA hsa-miR-146b-5p MAGEE1 2.23105707690238 3.83997814011313e-23 -1.1878604126008 1.83454769556238e-05 miRanda -0.434549768726919 1.68519646046177e-10 NA NA NA hsa-miR-146b-5p MAGEL2 2.23105707690238 3.83997814011313e-23 0.260794586212531 0.462814580953791 miRanda -0.196775047107158 0.0264746518651212 NA NA NA hsa-miR-200a-3p MAGI2 2.02394729844446 2.21240501925011e-08 -1.08226968916823 1.08040975630449e-05 miRNATAP -0.443278950668593 6.84326364283673e-35 NA NA NA hsa-miR-146b-5p MAGI3 2.23105707690238 3.83997814011313e-23 -0.700292909036225 2.29339823396249e-09 miRanda -0.144764666443258 9.76107097096086e-07 NA NA NA hsa-miR-1-3p MAL2 -2.73171785118192 3.4424534921136e-12 1.09741410006814 0.000256815827212029 MirTarget -0.173323773914887 0.000110034238006562 NA NA NA hsa-miR-135b-5p MAN1A1 2.80066701698235 2.12546333413447e-11 -0.232614410787678 0.191101565275525 MirTarget -0.101159426600916 9.32918222234111e-05 NA NA NA hsa-miR-146b-5p MAN1C1 2.23105707690238 3.83997814011313e-23 -0.35749632927137 0.105678729225202 mirMAP -0.223563192138049 4.23413373452784e-05 NA NA NA hsa-miR-194-5p MAN1C1 2.24386881692218 9.35116329002209e-11 -0.35749632927137 0.105678729225202 miRNATAP -0.180182997876554 1.05607872502493e-06 NA NA NA hsa-miR-146b-5p MANSC1 2.23105707690238 3.83997814011313e-23 -0.103184960128545 0.521333010406115 miRanda -0.104882142436919 0.00873925299880585 NA NA NA hsa-miR-146b-5p MAOA 2.23105707690238 3.83997814011313e-23 -1.91184973710307 8.09771540122623e-12 miRanda -0.44183636337028 3.77368361325019e-10 NA NA NA hsa-miR-335-3p MAOA 2.29463721765513 4.1956113745077e-18 -1.91184973710307 8.09771540122623e-12 mirMAP -0.199530222515914 0.00149965711514651 NA NA NA hsa-miR-194-5p MAP1B 2.24386881692218 9.35116329002209e-11 -0.558714866074475 0.0502101250165206 MirTarget -0.42629689061277 2.3894387931712e-21 NA NA NA hsa-miR-200a-3p MAP1B 2.02394729844446 2.21240501925011e-08 -0.558714866074475 0.0502101250165206 mirMAP -0.509380399748461 2.52356487513411e-35 NA NA NA hsa-miR-200b-3p MAP1B 2.06025765178663 3.07718049337497e-10 -0.558714866074475 0.0502101250165206 TargetScan -0.541138644105683 1.70742285853639e-32 NA NA NA hsa-miR-194-5p MAP2 2.24386881692218 9.35116329002209e-11 -0.497717570068985 0.0674635842749691 MirTarget;miRNATAP -0.360756678448586 1.51546379873834e-16 NA NA NA hsa-miR-200a-3p MAP2 2.02394729844446 2.21240501925011e-08 -0.497717570068985 0.0674635842749691 miRNATAP -0.326792134504076 1.718779026927e-14 NA NA NA hsa-miR-200b-3p MAP2 2.06025765178663 3.07718049337497e-10 -0.497717570068985 0.0674635842749691 MirTarget;TargetScan -0.330601450202759 2.46203336951485e-12 NA NA NA hsa-miR-935 MAP2 2.321600496365 1.00042201726114e-07 -0.497717570068985 0.0674635842749691 mirMAP -0.253553467684502 2.36018593876729e-11 NA NA NA hsa-miR-146b-5p MAP2K5 2.23105707690238 3.83997814011313e-23 -0.366872539695206 3.16163666287305e-06 miRanda -0.121707340997862 2.2583949082897e-10 NA NA NA hsa-miR-194-5p MAP3K3 2.24386881692218 9.35116329002209e-11 -0.290635931768054 0.0156524405164107 miRNATAP -0.210885688402431 3.65071795765775e-31 NA NA NA hsa-miR-200a-3p MAP3K3 2.02394729844446 2.21240501925011e-08 -0.290635931768054 0.0156524405164107 miRNATAP -0.23058659701943 4.4914330528142e-43 NA NA NA hsa-miR-146b-5p MAP4 2.23105707690238 3.83997814011313e-23 -0.163588092539192 0.111437492900646 miRanda -0.128029070324415 3.16488024516454e-07 NA NA NA hsa-miR-18a-5p MAP4 2.04701000113742 1.30593450319289e-12 -0.163588092539192 0.111437492900646 miRNATAP -0.165519197013945 2.00992977452651e-17 NA NA NA hsa-miR-146b-5p MAP6 2.23105707690238 3.83997814011313e-23 -1.67757744509068 8.39324357183999e-08 miRanda -0.667720338139954 4.72857414862663e-19 NA NA NA hsa-miR-18a-5p MAP7D1 2.04701000113742 1.30593450319289e-12 -0.417757032591807 0.00158402713713047 miRNAWalker2_validate;MirTarget;miRNATAP -0.219915467735183 2.93557819973434e-18 NA NA NA hsa-miR-200a-3p MAP7D1 2.02394729844446 2.21240501925011e-08 -0.417757032591807 0.00158402713713047 MirTarget;miRNATAP -0.241813727769577 2.39648594250692e-37 NA NA NA hsa-miR-935 MAP7D2 2.321600496365 1.00042201726114e-07 -3.15248029415936 1.01705233372113e-09 miRNATAP -0.179900450586676 0.0196637765211168 NA NA NA hsa-miR-200a-5p MAP9 2.19152245759943 3.17968183522514e-11 -0.772013653464035 0.00212612224981171 mirMAP -0.350654130773794 1.60500675721733e-16 NA NA NA hsa-miR-146b-5p MAPK10 2.23105707690238 3.83997814011313e-23 -1.77442731824666 3.99252070240734e-09 miRanda -0.537925599551711 4.57136650006246e-13 NA NA NA hsa-miR-935 MAPK10 2.321600496365 1.00042201726114e-07 -1.77442731824666 3.99252070240734e-09 miRNATAP -0.39239427580067 3.78935582148855e-21 NA NA NA hsa-miR-21-5p MAPK14 2.21515015440792 6.0468197386674e-49 -0.264617539435905 0.000870083553128048 mirMAP -0.123351418763894 3.49443256734132e-06 NA NA NA hsa-miR-146b-5p MAPK4 2.23105707690238 3.83997814011313e-23 -3.20102969321359 3.36120356375601e-07 miRanda -1.42070838421593 8.38600883743841e-22 NA NA NA hsa-miR-183-5p MAPK4 2.08412478942637 1.08931431254487e-10 -3.20102969321359 3.36120356375601e-07 MirTarget -1.12697075206759 2.74598635615224e-26 NA NA NA hsa-miR-18a-5p MAPK4 2.04701000113742 1.30593450319289e-12 -3.20102969321359 3.36120356375601e-07 MirTarget -1.08716982132474 3.7690513788677e-19 NA NA NA hsa-miR-200b-3p MAPK7 2.06025765178663 3.07718049337497e-10 -0.529711799741987 2.28293300945009e-08 MirTarget -0.118649499347647 1.35064051690857e-12 NA NA NA hsa-miR-183-5p MAPK8IP1 2.08412478942637 1.08931431254487e-10 -1.02276703697023 0.000266951272110321 MirTarget;miRNATAP -0.281314097664309 2.5763171574868e-08 NA NA NA hsa-miR-200a-3p MAPKBP1 2.02394729844446 2.21240501925011e-08 -0.576781314937829 3.57637840260116e-07 mirMAP -0.147407736434597 1.70862599514159e-16 NA NA NA hsa-miR-146b-3p MAPT 2.08650140817622 5.3293570720033e-22 -1.50879519002787 0.000122042938163989 miRNATAP -0.627865669435541 4.47268997506295e-10 NA NA NA hsa-miR-146b-5p MAPT 2.23105707690238 3.83997814011313e-23 -1.50879519002787 0.000122042938163989 PITA;miRNATAP -0.690656217836323 3.61696832009977e-13 NA NA NA hsa-miR-200b-3p MARCH8 2.06025765178663 3.07718049337497e-10 -0.597317477363774 4.01259740637912e-06 MirTarget;TargetScan -0.139309928775565 1.4692831341423e-09 NA NA NA hsa-miR-146b-5p MARK1 2.23105707690238 3.83997814011313e-23 -0.523915108301591 0.10034889097733 PITA;miRanda;miRNATAP -0.513408100752383 2.35172083101481e-11 NA NA NA hsa-miR-200b-3p MARVELD1 2.06025765178663 3.07718049337497e-10 0.264892992973576 0.160349949291816 mirMAP -0.314883760652424 4.17669130088476e-24 NA NA NA hsa-miR-335-3p MAST4 2.29463721765513 4.1956113745077e-18 -0.520795064221891 0.00156428290589899 mirMAP -0.158549908067881 7.38445735090969e-06 NA NA NA hsa-miR-21-5p MATN2 2.21515015440792 6.0468197386674e-49 -1.43983366621788 4.99408258343159e-06 miRNATAP -0.736395128511911 2.17401856129728e-12 NA NA NA hsa-miR-335-3p MATN2 2.29463721765513 4.1956113745077e-18 -1.43983366621788 4.99408258343159e-06 mirMAP -0.423511497194807 3.17691804656241e-10 NA NA NA hsa-miR-335-3p MB21D2 2.29463721765513 4.1956113745077e-18 -0.625679486428465 0.000244435791838717 MirTarget -0.121705501678558 0.00103310375537155 NA NA NA hsa-miR-146b-5p MBD5 2.23105707690238 3.83997814011313e-23 -0.418283005723191 0.000358917823942013 miRanda -0.190868641768116 1.72380987517991e-11 NA NA NA hsa-miR-200b-3p MBD5 2.06025765178663 3.07718049337497e-10 -0.418283005723191 0.000358917823942013 TargetScan -0.183003824129791 1.87474668108529e-20 NA NA NA hsa-miR-183-5p MBNL1 2.08412478942637 1.08931431254487e-10 -0.264288076974033 0.031330406144267 MirTarget;miRNATAP -0.209699755453404 9.11824078131269e-25 NA NA NA hsa-miR-200a-3p MBNL1 2.02394729844446 2.21240501925011e-08 -0.264288076974033 0.031330406144267 MirTarget;miRNATAP -0.175047564385496 6.76645773314578e-21 NA NA NA hsa-miR-200a-5p MBNL1 2.19152245759943 3.17968183522514e-11 -0.264288076974033 0.031330406144267 MirTarget -0.190528713183228 4.28709197607861e-21 NA NA NA hsa-miR-200b-3p MBNL1 2.06025765178663 3.07718049337497e-10 -0.264288076974033 0.031330406144267 TargetScan -0.183115479740923 7.97322084768595e-19 NA NA NA hsa-miR-21-5p MBNL1 2.21515015440792 6.0468197386674e-49 -0.264288076974033 0.031330406144267 miRNAWalker2_validate;MirTarget;miRNATAP -0.135203765968342 0.00112555669494875 NA NA NA hsa-miR-335-3p MBNL1 2.29463721765513 4.1956113745077e-18 -0.264288076974033 0.031330406144267 MirTarget -0.140072082593003 6.82315744629467e-08 NA NA NA hsa-miR-146b-5p MBNL2 2.23105707690238 3.83997814011313e-23 -0.199715343562235 0.128021493866242 miRanda -0.102668875922303 0.00160408320959163 NA NA NA hsa-miR-18a-5p MBNL2 2.04701000113742 1.30593450319289e-12 -0.199715343562235 0.128021493866242 miRNATAP -0.132909631637816 3.28113117847914e-07 NA NA NA hsa-miR-194-5p MBNL2 2.24386881692218 9.35116329002209e-11 -0.199715343562235 0.128021493866242 miRNATAP -0.104330929060754 1.8592759498306e-06 NA NA NA hsa-miR-192-5p MCAM 2.0867723747501 3.57854249239079e-08 -0.323857758583791 0.133834564119439 miRNAWalker2_validate -0.295629489308951 4.88186861300647e-21 NA NA NA hsa-miR-146b-5p MCC 2.23105707690238 3.83997814011313e-23 -1.00471938976376 1.64318673576847e-06 miRanda -0.294037881538889 1.61168498775964e-08 NA NA NA hsa-miR-200a-5p MCC 2.19152245759943 3.17968183522514e-11 -1.00471938976376 1.64318673576847e-06 MirTarget -0.366450088909977 2.18560120203018e-26 NA NA NA hsa-miR-200b-3p MCC 2.06025765178663 3.07718049337497e-10 -1.00471938976376 1.64318673576847e-06 TargetScan -0.366970725681043 1.07588149883515e-25 NA NA NA hsa-miR-21-5p MCC 2.21515015440792 6.0468197386674e-49 -1.00471938976376 1.64318673576847e-06 mirMAP -0.404340026286641 1.1560659270862e-08 NA NA NA hsa-miR-141-5p MCTP1 2.13747696823946 1.73124674554872e-11 0.150736371958805 0.414432728143644 MirTarget;miRNATAP -0.131071551358192 0.000103347926016577 NA NA NA hsa-miR-335-3p MDFIC 2.29463721765513 4.1956113745077e-18 -0.494755337655397 0.0058275399529401 MirTarget -0.271985008498603 3.07791488086781e-13 NA NA NA hsa-miR-135b-5p MDGA1 2.80066701698235 2.12546333413447e-11 -0.700553829949079 0.00274428133644597 mirMAP -0.224366110782435 1.73092058386487e-11 NA NA NA hsa-miR-18a-5p MDGA1 2.04701000113742 1.30593450319289e-12 -0.700553829949079 0.00274428133644597 miRNATAP -0.345879347486389 2.76833300058244e-14 NA NA NA hsa-miR-200a-3p MDGA1 2.02394729844446 2.21240501925011e-08 -0.700553829949079 0.00274428133644597 miRNATAP -0.348967200043765 1.01152167315394e-22 NA NA NA hsa-miR-146b-5p ME1 2.23105707690238 3.83997814011313e-23 -1.58657845238805 1.47714037243395e-12 miRanda -0.302772966321469 1.26911615234238e-07 NA NA NA hsa-miR-146b-5p MECP2 2.23105707690238 3.83997814011313e-23 -0.152019401131295 0.153664300014582 mirMAP -0.15893605918822 5.91780231990212e-10 NA NA NA hsa-miR-183-5p MECP2 2.08412478942637 1.08931431254487e-10 -0.152019401131295 0.153664300014582 mirMAP -0.143007942109512 7.06065802124353e-15 NA NA NA hsa-miR-192-5p MECP2 2.0867723747501 3.57854249239079e-08 -0.152019401131295 0.153664300014582 mirMAP;miRNATAP -0.154401242855911 3.48581529582603e-24 NA NA NA hsa-miR-194-5p MECP2 2.24386881692218 9.35116329002209e-11 -0.152019401131295 0.153664300014582 mirMAP;miRNATAP -0.165087084665927 1.57996863967772e-23 NA NA NA hsa-miR-21-5p MECP2 2.21515015440792 6.0468197386674e-49 -0.152019401131295 0.153664300014582 mirMAP -0.172740684139068 1.09456440804027e-06 NA NA NA hsa-miR-335-3p MECP2 2.29463721765513 4.1956113745077e-18 -0.152019401131295 0.153664300014582 mirMAP -0.117064286379189 1.92198395946708e-07 NA NA NA hsa-miR-146b-3p MED12L 2.08650140817622 5.3293570720033e-22 -0.193902580891031 0.552988997113131 miRNATAP -0.169132732178878 0.0476503225009472 NA NA NA hsa-miR-183-5p MED12L 2.08412478942637 1.08931431254487e-10 -0.193902580891031 0.552988997113131 miRNATAP -0.30521904219631 1.69051003018671e-07 NA NA NA hsa-miR-1-3p MED14 -2.73171785118192 3.4424534921136e-12 0.524405952276254 2.74588291468926e-06 MirTarget -0.11904454096115 1.67509213685913e-13 NA NA NA hsa-miR-146b-5p MEF2A 2.23105707690238 3.83997814011313e-23 -0.299000743634786 0.0124150173611637 miRanda -0.187652198322475 7.85459327851325e-11 NA NA NA hsa-miR-21-5p MEF2A 2.21515015440792 6.0468197386674e-49 -0.299000743634786 0.0124150173611637 miRNAWalker2_validate -0.187899122982137 2.72404798135243e-06 NA NA NA hsa-miR-335-3p MEF2A 2.29463721765513 4.1956113745077e-18 -0.299000743634786 0.0124150173611637 mirMAP -0.183166216160509 1.27901700540822e-13 NA NA NA hsa-miR-135b-5p MEF2C 2.80066701698235 2.12546333413447e-11 -0.498587747456098 0.014475128958342 MirTarget -0.23231834996581 2.90576483123623e-16 NA NA NA hsa-miR-183-5p MEF2C 2.08412478942637 1.08931431254487e-10 -0.498587747456098 0.014475128958342 MirTarget;miRNATAP -0.369930083014387 3.0574924541028e-28 NA NA NA hsa-miR-18a-5p MEF2C 2.04701000113742 1.30593450319289e-12 -0.498587747456098 0.014475128958342 MirTarget -0.311082037270383 2.58582003021102e-15 NA NA NA hsa-miR-194-5p MEF2C 2.24386881692218 9.35116329002209e-11 -0.498587747456098 0.014475128958342 miRNATAP -0.230075245815547 5.84125959421238e-12 NA NA NA hsa-miR-21-5p MEF2C 2.21515015440792 6.0468197386674e-49 -0.498587747456098 0.014475128958342 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.227454002726562 0.00101817169687185 NA NA NA hsa-miR-335-3p MEF2C 2.29463721765513 4.1956113745077e-18 -0.498587747456098 0.014475128958342 MirTarget;mirMAP -0.358419200036672 6.11530901149404e-18 NA NA NA hsa-miR-18a-5p MEF2D 2.04701000113742 1.30593450319289e-12 -0.504357600247539 1.81613073647628e-06 miRNATAP -0.168788654803673 1.92881453877415e-16 NA NA NA hsa-miR-200b-3p MEF2D 2.06025765178663 3.07718049337497e-10 -0.504357600247539 1.81613073647628e-06 TargetScan;mirMAP -0.168029120413218 6.6353408756682e-21 NA NA NA hsa-miR-92a-1-5p MEF2D 2.04820501765632 9.32117486799495e-13 -0.504357600247539 1.81613073647628e-06 mirMAP -0.134350137338579 4.97519775559691e-10 NA NA NA hsa-miR-200b-3p MEGF10 2.06025765178663 3.07718049337497e-10 -0.588656686146848 0.0848159063822668 MirTarget -0.360559718873467 1.78614289734057e-09 NA NA NA hsa-miR-335-3p MEGF10 2.29463721765513 4.1956113745077e-18 -0.588656686146848 0.0848159063822668 MirTarget -0.225511729322996 0.00223681129231998 NA NA NA hsa-miR-200a-3p MEGF9 2.02394729844446 2.21240501925011e-08 -0.600901388206393 5.01783667124578e-08 miRNATAP -0.11388107205686 2.02106739355631e-10 NA NA NA hsa-miR-21-5p MEGF9 2.21515015440792 6.0468197386674e-49 -0.600901388206393 5.01783667124578e-08 miRNAWalker2_validate;mirMAP;miRNATAP -0.219388990787695 3.97388718929709e-09 NA NA NA hsa-miR-335-3p MEGF9 2.29463721765513 4.1956113745077e-18 -0.600901388206393 5.01783667124578e-08 MirTarget;mirMAP -0.165118553372504 1.6725125101612e-12 NA NA NA hsa-miR-146b-5p MEIS1 2.23105707690238 3.83997814011313e-23 -1.0148748088312 5.58199831086994e-05 miRanda -0.36990734907412 2.36151512816634e-09 NA NA NA hsa-miR-21-5p MEIS1 2.21515015440792 6.0468197386674e-49 -1.0148748088312 5.58199831086994e-05 miRNAWalker2_validate -0.536557416133542 1.67837729853715e-10 NA NA NA hsa-miR-192-5p MEIS2 2.0867723747501 3.57854249239079e-08 -0.883335732687269 4.11894676730037e-05 miRNAWalker2_validate -0.178893258910726 9.75009546453556e-08 NA NA NA hsa-miR-194-5p MEIS2 2.24386881692218 9.35116329002209e-11 -0.883335732687269 4.11894676730037e-05 MirTarget;miRNATAP -0.167523429937415 4.62412877737366e-06 NA NA NA hsa-miR-335-3p MEOX2 2.29463721765513 4.1956113745077e-18 -0.305974715077866 0.450206805337241 mirMAP -0.422216600660037 9.50783356840648e-07 NA NA NA hsa-miR-1-3p MET -2.73171785118192 3.4424534921136e-12 1.57615611374924 2.64556490930012e-12 miRTarBase -0.154629845683453 7.76035855439818e-06 26499783;27169691 Moreover both EGCG and miR-1 mimic inhibited c-MET expression and combination treatment with EGCG and c-MET inhibitor crizotinib had enhanced inhibitory effects on the growth of MG-63 and U-2OS cells;Dual receptor EGFR and c MET inhibition by tumor suppressive miR 1 and miR 206 in head and neck squamous cell carcinoma ; sarcoma;head and neck cancer hsa-miR-146b-5p METTL7A 2.23105707690238 3.83997814011313e-23 -1.82176275788613 2.28373047084918e-15 miRanda -0.345428053328687 5.0861758021548e-09 NA NA NA hsa-miR-335-3p METTL7A 2.29463721765513 4.1956113745077e-18 -1.82176275788613 2.28373047084918e-15 mirMAP -0.390313451254702 5.76374098383735e-15 NA NA NA hsa-miR-192-5p MEX3B 2.0867723747501 3.57854249239079e-08 0.725871921297744 2.11635015696509e-05 miRNAWalker2_validate -0.153542338378413 6.60207072457244e-09 NA NA NA hsa-miR-200b-3p MEX3B 2.06025765178663 3.07718049337497e-10 0.725871921297744 2.11635015696509e-05 TargetScan -0.153574218897037 5.38729628636004e-07 NA NA NA hsa-miR-200a-3p MFAP3L 2.02394729844446 2.21240501925011e-08 0.770933863602886 0.010377932646622 MirTarget -0.166846221981091 0.000725833783490721 NA NA NA hsa-miR-200a-5p MFAP3L 2.19152245759943 3.17968183522514e-11 0.770933863602886 0.010377932646622 MirTarget -0.190050609606336 0.000376261187158414 NA NA NA hsa-miR-200b-3p MFAP5 2.06025765178663 3.07718049337497e-10 -1.38773655702249 0.000288777288845266 TargetScan -0.566283218300622 5.08454872408137e-18 NA NA NA hsa-miR-146b-3p MGP 2.08650140817622 5.3293570720033e-22 -0.442751018154892 0.204316342123438 MirTarget -0.273093061569529 0.00263741443613274 NA NA NA hsa-miR-141-5p MICAL3 2.13747696823946 1.73124674554872e-11 0.170604513293195 0.185745641608746 mirMAP -0.150400944971019 5.40945733468217e-11 NA NA NA hsa-miR-200a-3p MICAL3 2.02394729844446 2.21240501925011e-08 0.170604513293195 0.185745641608746 mirMAP -0.130023909469161 1.94317188201342e-10 NA NA NA hsa-miR-335-3p MIPOL1 2.29463721765513 4.1956113745077e-18 -0.447829692526657 0.0518176143675605 mirMAP -0.17928037630007 0.000297917240733922 NA NA NA hsa-miR-335-3p MITF 2.29463721765513 4.1956113745077e-18 -0.768678066533393 0.000222708938697959 mirMAP -0.398007587195781 3.68822465718511e-21 NA NA NA hsa-miR-183-5p MKL2 2.08412478942637 1.08931431254487e-10 -0.0606062035513188 0.556642646863117 miRNATAP -0.124574056300023 3.86787666019667e-12 NA NA NA hsa-miR-21-5p MKNK2 2.21515015440792 6.0468197386674e-49 -0.817359756676615 2.08516589759381e-11 miRNAWalker2_validate -0.276823985433867 2.54965706847016e-11 NA NA NA hsa-miR-335-3p MKX 2.29463721765513 4.1956113745077e-18 -0.435370995520897 0.251965832901685 MirTarget -0.42894454067166 9.93075344602454e-08 NA NA NA hsa-miR-335-3p MLLT3 2.29463721765513 4.1956113745077e-18 -0.428165431581205 0.00991986731478072 MirTarget;mirMAP -0.102627376194818 0.00431591437430618 NA NA NA hsa-miR-200b-3p MMD 2.06025765178663 3.07718049337497e-10 0.358596402380194 0.0168656186141133 TargetScan -0.211248938604231 1.41711462495963e-16 NA NA NA hsa-miR-135b-5p MMP16 2.80066701698235 2.12546333413447e-11 0.339181683389834 0.222873688272483 mirMAP -0.221779229172498 2.82334841447547e-08 NA NA NA hsa-miR-141-5p MMP16 2.13747696823946 1.73124674554872e-11 0.339181683389834 0.222873688272483 mirMAP -0.396558639797765 3.26115184818317e-16 NA NA NA hsa-miR-146b-5p MMP16 2.23105707690238 3.83997814011313e-23 0.339181683389834 0.222873688272483 miRNAWalker2_validate;MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.251314227721671 0.000267723989148661 21823013;26549292 Inhibitory effects of miR 146b 5p on cell migration and invasion of pancreatic cancer by targeting MMP16; Furthermore we found that matrix metalloproteinase 16 MMP16 was a downstream target of miR-146b-5p by dual-luciferase reporter assay; Altogether our findings suggest that miR-146b-5p may be involved in pancreatic cancer cell migration and invasion by targeting MMP16 and miR-146b-5p may be a potential therapeutic target for the pancreatic cancer;Results of western blot assay indicated that miR-146b-5p increased MMP-16 protein expression and showed a decrease of ZNRF3 protein cell migration; pancreatic cancer;sarcoma hsa-miR-200a-5p MMP16 2.19152245759943 3.17968183522514e-11 0.339181683389834 0.222873688272483 mirMAP -0.345598673589628 2.96369936509274e-13 NA NA NA hsa-miR-200b-3p MMP16 2.06025765178663 3.07718049337497e-10 0.339181683389834 0.222873688272483 TargetScan -0.362457134683772 3.33943366473066e-14 NA NA NA hsa-miR-146b-3p MMP24 2.08650140817622 5.3293570720033e-22 -0.146943398657157 0.373666022520055 MirTarget;miRNATAP -0.13025366219785 0.00238292495920565 NA NA NA hsa-miR-146b-5p MMP24 2.23105707690238 3.83997814011313e-23 -0.146943398657157 0.373666022520055 miRanda -0.12118780739209 0.00312584259395123 NA NA NA hsa-miR-146b-5p MMRN1 2.23105707690238 3.83997814011313e-23 -2.57783578309417 8.43164107296075e-13 miRanda -0.599073878891735 4.49902328369222e-11 NA NA NA hsa-miR-335-3p MMRN1 2.29463721765513 4.1956113745077e-18 -2.57783578309417 8.43164107296075e-13 MirTarget -0.659016873670758 8.2902018881408e-18 NA NA NA hsa-miR-146b-5p MMRN2 2.23105707690238 3.83997814011313e-23 -0.0433024025851951 0.803822546853121 miRanda -0.109781988449023 0.0113426678014407 NA NA NA hsa-miR-192-5p MOAP1 2.0867723747501 3.57854249239079e-08 -0.635870544992165 1.26658509837612e-08 miRNAWalker2_validate -0.148788209309688 8.24998808481234e-19 NA NA NA hsa-miR-21-5p MOAP1 2.21515015440792 6.0468197386674e-49 -0.635870544992165 1.26658509837612e-08 miRNAWalker2_validate -0.338773807893189 5.90413589071478e-21 NA NA NA hsa-miR-146b-3p MOB1B 2.08650140817622 5.3293570720033e-22 0.196782820345945 0.152662671546993 miRNATAP -0.125147710861731 0.000441265341910749 NA NA NA hsa-miR-200a-5p MOB1B 2.19152245759943 3.17968183522514e-11 0.196782820345945 0.152662671546993 mirMAP -0.138368405245846 6.03061998260202e-09 NA NA NA hsa-miR-200b-3p MOB1B 2.06025765178663 3.07718049337497e-10 0.196782820345945 0.152662671546993 mirMAP -0.114591408538838 2.55818354588371e-06 NA NA NA hsa-miR-92a-1-5p MOB3A 2.04820501765632 9.32117486799495e-13 -0.462243458747591 0.000100012457097538 mirMAP -0.108878727687716 9.41887900085277e-06 NA NA NA hsa-miR-200b-3p MOCS1 2.06025765178663 3.07718049337497e-10 -1.16957312236881 2.12145289838661e-08 TargetScan -0.326023117257929 1.49678082346333e-19 NA NA NA hsa-miR-335-3p MOCS2 2.29463721765513 4.1956113745077e-18 -0.754032718445293 6.81001569029833e-14 mirMAP -0.130511594392462 3.9503259998037e-09 NA NA NA hsa-miR-21-5p MOXD1 2.21515015440792 6.0468197386674e-49 -0.390155882839977 0.175727823704991 miRNAWalker2_validate -0.264815994480751 0.00680628252121414 NA NA NA hsa-miR-200b-3p MPDZ 2.06025765178663 3.07718049337497e-10 -0.571546582093139 0.0256067845486253 MirTarget -0.521922462796284 4.26083058888556e-39 NA NA NA hsa-miR-335-3p MPDZ 2.29463721765513 4.1956113745077e-18 -0.571546582093139 0.0256067845486253 MirTarget -0.421170304799243 1.22709694811216e-15 NA NA NA hsa-miR-141-5p MPP2 2.13747696823946 1.73124674554872e-11 -0.979304354602387 0.0006144308249289 mirMAP -0.462005228637283 9.71220502306794e-21 NA NA NA hsa-miR-146b-5p MPP2 2.23105707690238 3.83997814011313e-23 -0.979304354602387 0.0006144308249289 mirMAP -0.495664601651002 6.95465210087175e-13 NA NA NA hsa-miR-194-5p MPP2 2.24386881692218 9.35116329002209e-11 -0.979304354602387 0.0006144308249289 mirMAP -0.410411578694674 2.99028620410279e-19 NA NA NA hsa-miR-196a-5p MPP2 5.05945965885472 4.48343841468539e-25 -0.979304354602387 0.0006144308249289 miRNAWalker2_validate -0.192444321794715 2.73544152914228e-09 NA NA NA hsa-miR-335-3p MPP7 2.29463721765513 4.1956113745077e-18 -1.18309458213408 8.37117939953953e-06 MirTarget;mirMAP -0.207314106225955 0.000355908921634889 NA NA NA hsa-miR-335-3p MPPE1 2.29463721765513 4.1956113745077e-18 -0.382735245681322 4.39922658809777e-05 mirMAP -0.103837178463873 2.11767259485749e-07 NA NA NA hsa-miR-135b-5p MPPED2 2.80066701698235 2.12546333413447e-11 -0.986462925154127 0.000324008627289851 mirMAP -0.294204373214342 3.63496868708137e-14 NA NA NA hsa-miR-18a-5p MPPED2 2.04701000113742 1.30593450319289e-12 -0.986462925154127 0.000324008627289851 mirMAP -0.518545367605717 7.14776708357674e-24 NA NA NA hsa-miR-192-5p MPPED2 2.0867723747501 3.57854249239079e-08 -0.986462925154127 0.000324008627289851 mirMAP -0.464411741263771 7.58464766038827e-34 NA NA NA hsa-miR-146b-5p MPV17L 2.23105707690238 3.83997814011313e-23 -0.966204248117569 0.018437279474828 miRanda -0.517788071039681 2.78227939327999e-07 NA NA NA hsa-miR-141-5p MR1 2.13747696823946 1.73124674554872e-11 -0.366214668854833 0.0102661860423976 MirTarget -0.138739693248034 8.02282368383857e-08 NA NA NA hsa-miR-200a-3p MR1 2.02394729844446 2.21240501925011e-08 -0.366214668854833 0.0102661860423976 mirMAP -0.141342781641851 5.3671788421297e-10 NA NA NA hsa-miR-92a-1-5p MR1 2.04820501765632 9.32117486799495e-13 -0.366214668854833 0.0102661860423976 MirTarget -0.137395924868831 2.64467359274527e-06 NA NA NA hsa-miR-21-5p MRAP2 2.21515015440792 6.0468197386674e-49 -1.64970042412983 9.30116817421979e-05 miRNAWalker2_validate -0.466435851891185 0.00127896384482684 NA NA NA hsa-miR-135b-5p MRAS 2.80066701698235 2.12546333413447e-11 -0.140957991947981 0.473453737783408 miRNATAP -0.211563925261573 1.25212067884256e-14 NA NA NA hsa-miR-146b-5p MRAS 2.23105707690238 3.83997814011313e-23 -0.140957991947981 0.473453737783408 miRanda -0.129750159723354 0.00799914561403367 NA NA NA hsa-miR-335-3p MRAS 2.29463721765513 4.1956113745077e-18 -0.140957991947981 0.473453737783408 mirMAP -0.261732582563415 1.90750473678443e-10 NA NA NA hsa-miR-141-5p MRVI1 2.13747696823946 1.73124674554872e-11 -1.05140631323179 0.000224288363483435 MirTarget -0.590436168164092 2.10318853811656e-37 NA NA NA hsa-miR-146b-5p MRVI1 2.23105707690238 3.83997814011313e-23 -1.05140631323179 0.000224288363483435 miRanda -0.53527758976869 4.58385590245659e-15 NA NA NA hsa-miR-183-5p MRVI1 2.08412478942637 1.08931431254487e-10 -1.05140631323179 0.000224288363483435 miRNATAP -0.639519839220763 1.65139562485694e-48 NA NA NA hsa-miR-200b-3p MRVI1 2.06025765178663 3.07718049337497e-10 -1.05140631323179 0.000224288363483435 MirTarget -0.568324676246731 4.19246277200708e-36 NA NA NA hsa-miR-335-3p MS4A1 2.29463721765513 4.1956113745077e-18 -0.253251841825237 0.664533440628056 mirMAP -0.583306720486606 2.7241988883074e-06 NA NA NA hsa-miR-192-5p MSN 2.0867723747501 3.57854249239079e-08 -0.0225963425243751 0.884221645798909 miRNAWalker2_validate;MirTarget -0.18470821036508 9.04356450598895e-16 NA NA NA hsa-miR-200b-3p MSN 2.06025765178663 3.07718049337497e-10 -0.0225963425243751 0.884221645798909 MirTarget;TargetScan -0.249946258334778 2.15257262157223e-22 24037528 MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways; Instead we found that miR-200b repressed several actin-associated genes with the knockdown of the ezrin-radixin-moesin family member moesin alone phenocopying the repression of cell invasion by miR-200b; Moesin was verified to be directly targeted by miR-200b and restoration of moesin in miR-200b-expressing cells was sufficient to alleviate metastatic repression; In breast cancer cell lines and patient samples the expression of moesin significantly inversely correlated with miR-200 expression and high levels of moesin were associated with poor relapse-free survival metastasis;poor survival breast cancer hsa-miR-146b-3p MSRB3 2.08650140817622 5.3293570720033e-22 -1.1706465232609 0.000126305414645397 miRNATAP -0.523804037562747 1.65491836040131e-11 NA NA NA hsa-miR-192-5p MSRB3 2.0867723747501 3.57854249239079e-08 -1.1706465232609 0.000126305414645397 miRNAWalker2_validate -0.539563165395478 1.15236524330651e-37 NA NA NA hsa-miR-200b-3p MSRB3 2.06025765178663 3.07718049337497e-10 -1.1706465232609 0.000126305414645397 mirMAP -0.647495050583194 1.88288375884873e-42 NA NA NA hsa-miR-192-5p MT1X 2.0867723747501 3.57854249239079e-08 -2.05507506191053 8.36968885566554e-17 miRNAWalker2_validate -0.173858680305887 1.993845233099e-05 NA NA NA hsa-miR-21-5p MTMR12 2.21515015440792 6.0468197386674e-49 -0.253572180104434 0.0236206016681598 miRNAWalker2_validate;miRNATAP -0.163265111729 1.39000796232176e-05 NA NA NA hsa-miR-21-5p MTMR3 2.21515015440792 6.0468197386674e-49 -0.319277717945972 0.00012017677158067 mirMAP -0.117625508459563 2.65874426200345e-05 NA NA NA hsa-miR-192-5p MTR 2.0867723747501 3.57854249239079e-08 0.255769098079923 0.0330279152571092 mirMAP -0.120198669791775 3.52637451083994e-11 NA NA NA hsa-miR-135b-5p MTSS1 2.80066701698235 2.12546333413447e-11 -0.810088738785264 0.000353714566592768 MirTarget -0.174057100056687 1.30433380727734e-07 24343340 MicroRNA 135b regulates metastasis suppressor 1 expression and promotes migration and invasion in colorectal cancer; In this study we evaluated the role of miR-135b in colorectal cancer CRC and its regulatory role for metastasis suppressor-1 MTSS1 and its mechanisms; The levels of miR-135b and MTSS1 gene expression in 35 CRC and corresponding cancer-adjacent tissues 27 colorectal adenoma and 16 normal tissue samples were quantified using qRT-PCR and western blot analysis; CRC tissues showed significantly upregulated miR-135b expression and reduced MTSS1 expression; The miR-135b inhibitor decreased miR-135b expression and caused MTSS1 upregulation at the post-transcriptional level; However overexpression of miR-135b caused MTSS1 protein downregulation; The 3'-UTR of MTSS1 harbored a binding site for miR-135b; Our results demonstrated that miR-135b downregulated MTSS1 expression and contributed to CRC cell invasion indicating its involvement in CRC progression metastasis;progression colorectal cancer hsa-miR-146b-5p MTSS1 2.23105707690238 3.83997814011313e-23 -0.810088738785264 0.000353714566592768 miRanda -0.292481934972783 1.78400534188494e-07 19190326 Breast cancer metastasis suppressor 1 up regulates miR 146 which suppresses breast cancer metastasis metastasis breast cancer hsa-miR-192-5p MTSS1 2.0867723747501 3.57854249239079e-08 -0.810088738785264 0.000353714566592768 miRNAWalker2_validate -0.208890185970704 2.28942522682014e-09 NA NA NA hsa-miR-194-5p MTSS1 2.24386881692218 9.35116329002209e-11 -0.810088738785264 0.000353714566592768 MirTarget;miRNATAP -0.219804927826124 6.66664379588481e-09 NA NA NA hsa-miR-200a-3p MTSS1 2.02394729844446 2.21240501925011e-08 -0.810088738785264 0.000353714566592768 miRNATAP -0.145963210050295 9.00819583793182e-05 NA NA NA hsa-miR-335-3p MTSS1 2.29463721765513 4.1956113745077e-18 -0.810088738785264 0.000353714566592768 mirMAP -0.213262467988188 1.31766675155663e-05 NA NA NA hsa-miR-935 MTSS1 2.321600496365 1.00042201726114e-07 -0.810088738785264 0.000353714566592768 MirTarget;PITA;miRNATAP -0.140420940634838 1.72306237377767e-05 NA NA NA hsa-miR-141-5p MTSS1L 2.13747696823946 1.73124674554872e-11 -0.0650296407852853 0.747126264282662 mirMAP -0.288497755872076 2.0691743528889e-16 NA NA NA hsa-miR-192-5p MTSS1L 2.0867723747501 3.57854249239079e-08 -0.0650296407852853 0.747126264282662 mirMAP -0.295296996670582 1.30644564996621e-24 NA NA NA hsa-miR-200b-3p MTSS1L 2.06025765178663 3.07718049337497e-10 -0.0650296407852853 0.747126264282662 TargetScan -0.285361312732457 6.91459830737785e-17 NA NA NA hsa-miR-146b-5p MTUS2 2.23105707690238 3.83997814011313e-23 -2.68967307566294 1.97873418378069e-11 miRanda -0.881062104718662 1.18335049627182e-19 NA NA NA hsa-miR-183-5p MUC15 2.08412478942637 1.08931431254487e-10 -1.67524066184172 0.0129571269342538 miRNATAP -0.331281560257833 0.00726789685721612 NA NA NA hsa-miR-335-3p MUC15 2.29463721765513 4.1956113745077e-18 -1.67524066184172 0.0129571269342538 mirMAP -0.295808031677407 0.0439690189408152 NA NA NA hsa-miR-146b-5p MXD4 2.23105707690238 3.83997814011313e-23 -0.518630488650339 8.01248091177692e-07 miRNATAP -0.107784374080563 4.39170216662296e-05 NA NA NA hsa-miR-183-5p MXD4 2.08412478942637 1.08931431254487e-10 -0.518630488650339 8.01248091177692e-07 miRNATAP -0.102120839733077 8.42409750400905e-08 NA NA NA hsa-miR-200b-3p MXD4 2.06025765178663 3.07718049337497e-10 -0.518630488650339 8.01248091177692e-07 TargetScan -0.109877588243222 4.52859499031595e-09 NA NA NA hsa-miR-146b-5p MXI1 2.23105707690238 3.83997814011313e-23 -0.986942900915952 1.94101534384788e-11 miRanda -0.289451841221308 1.11855323800258e-15 NA NA NA hsa-miR-192-5p MXI1 2.0867723747501 3.57854249239079e-08 -0.986942900915952 1.94101534384788e-11 miRNAWalker2_validate -0.198188222406647 1.00103605957037e-18 NA NA NA hsa-miR-200b-3p MXI1 2.06025765178663 3.07718049337497e-10 -0.986942900915952 1.94101534384788e-11 TargetScan -0.190119656442599 5.76647650620571e-13 NA NA NA hsa-miR-335-3p MXI1 2.29463721765513 4.1956113745077e-18 -0.986942900915952 1.94101534384788e-11 MirTarget;mirMAP -0.177341243414518 4.07127099144613e-08 NA NA NA hsa-miR-146b-3p MXRA7 2.08650140817622 5.3293570720033e-22 -0.765493562327755 0.000850875415982323 MirTarget -0.418531514845326 4.68540848160753e-13 NA NA NA hsa-miR-146b-5p MXRA7 2.23105707690238 3.83997814011313e-23 -0.765493562327755 0.000850875415982323 mirMAP -0.465188370774463 9.88010954505968e-18 NA NA NA hsa-miR-200a-3p MYBL1 2.02394729844446 2.21240501925011e-08 0.493754443604026 0.0215216223713438 miRNATAP -0.141121772390249 5.59666133576828e-05 NA NA NA hsa-miR-335-3p MYCT1 2.29463721765513 4.1956113745077e-18 -0.391678588493405 0.0173501036991122 mirMAP -0.26791775274526 2.49230621097497e-15 NA NA NA hsa-miR-135b-5p MYEF2 2.80066701698235 2.12546333413447e-11 -1.50065972644809 0.000144351041165322 MirTarget -0.367164127512116 1.03626695654952e-10 NA NA NA hsa-miR-21-5p MYEF2 2.21515015440792 6.0468197386674e-49 -1.50065972644809 0.000144351041165322 miRNAWalker2_validate -0.824433664032106 3.91379859201315e-10 NA NA NA hsa-miR-335-3p MYEF2 2.29463721765513 4.1956113745077e-18 -1.50065972644809 0.000144351041165322 mirMAP -0.561549454638505 1.62262680429045e-11 NA NA NA hsa-miR-194-5p MYH10 2.24386881692218 9.35116329002209e-11 0.365808627615777 0.10713413161117 miRNATAP -0.255580916919112 5.68668049212517e-12 NA NA NA hsa-miR-200a-3p MYH10 2.02394729844446 2.21240501925011e-08 0.365808627615777 0.10713413161117 miRNATAP -0.28705946282956 3.89320659450499e-16 NA NA NA hsa-miR-146b-5p MYH11 2.23105707690238 3.83997814011313e-23 -2.89464657570417 1.22317347454103e-07 miRanda -1.17747566769839 1.98850852386114e-19 NA NA NA hsa-miR-146b-5p MYLK 2.23105707690238 3.83997814011313e-23 -1.44806395967964 9.65012105905573e-05 miRanda -0.723216406503347 3.73814974869433e-16 NA NA NA hsa-miR-200b-3p MYLK 2.06025765178663 3.07718049337497e-10 -1.44806395967964 9.65012105905573e-05 TargetScan -0.797611667528977 6.35192067341987e-44 NA NA NA hsa-miR-335-3p MYLK 2.29463721765513 4.1956113745077e-18 -1.44806395967964 9.65012105905573e-05 mirMAP -0.706394341602089 8.19109792676809e-21 NA NA NA hsa-miR-335-3p MYLK3 2.29463721765513 4.1956113745077e-18 -0.359286526658728 0.135711020428337 MirTarget;mirMAP -0.155254836600364 0.00281056670102472 NA NA NA hsa-miR-146b-5p MYLK4 2.23105707690238 3.83997814011313e-23 0.333416398515097 0.102749467602 miRanda -0.122380572464161 0.0164427818192115 NA NA NA hsa-miR-194-5p MYO5A 2.24386881692218 9.35116329002209e-11 -0.085562862894208 0.616615957919168 mirMAP -0.227721518327107 6.96144471725655e-17 NA NA NA hsa-miR-200b-3p MYO5A 2.06025765178663 3.07718049337497e-10 -0.085562862894208 0.616615957919168 mirMAP -0.210245729369494 9.38263584265489e-13 NA NA NA hsa-miR-335-3p MYO5A 2.29463721765513 4.1956113745077e-18 -0.085562862894208 0.616615957919168 mirMAP -0.189207658803473 1.6325796001316e-07 NA NA NA hsa-miR-200b-3p MYO9A 2.06025765178663 3.07718049337497e-10 -0.147200402080686 0.323729766315484 TargetScan -0.211125639834033 6.38546890420585e-17 NA NA NA hsa-miR-21-5p MYO9A 2.21515015440792 6.0468197386674e-49 -0.147200402080686 0.323729766315484 miRNAWalker2_validate -0.157350839286125 0.00178899475396405 NA NA NA hsa-miR-335-3p MYO9A 2.29463721765513 4.1956113745077e-18 -0.147200402080686 0.323729766315484 mirMAP -0.17462324993137 2.76196163485038e-08 NA NA NA hsa-miR-135b-5p MYOCD 2.80066701698235 2.12546333413447e-11 -2.14975667674387 3.74618848810371e-07 MirTarget;miRNATAP -0.517488023046768 4.26824790591303e-18 25190111 MicroRNA 135b promotes proliferation invasion and migration of osteosarcoma cells by degrading myocardin sarcoma hsa-miR-141-5p MYOCD 2.13747696823946 1.73124674554872e-11 -2.14975667674387 3.74618848810371e-07 mirMAP -0.836756811466317 3.4803745551625e-32 NA NA NA hsa-miR-335-3p MYOCD 2.29463721765513 4.1956113745077e-18 -2.14975667674387 3.74618848810371e-07 mirMAP -0.819191900276842 3.57420028907244e-21 NA NA NA hsa-miR-935 MYOT 2.321600496365 1.00042201726114e-07 -2.723578632759 1.99786740170611e-13 PITA -0.322740280649655 3.57534981333989e-09 NA NA NA hsa-miR-335-3p MYOZ3 2.29463721765513 4.1956113745077e-18 -0.133008068074241 0.688519812071387 mirMAP -0.270278381487808 0.000144756842111564 NA NA NA hsa-miR-935 MYPN 2.321600496365 1.00042201726114e-07 -2.04404198097227 1.52287185442999e-06 PITA -0.175420221421555 0.00502417043399563 NA NA NA hsa-miR-200a-3p MYRIP 2.02394729844446 2.21240501925011e-08 -2.5374866261714 8.43578141822633e-10 MirTarget -0.336891327300167 1.07782201796014e-06 NA NA NA hsa-miR-335-3p MYRIP 2.29463721765513 4.1956113745077e-18 -2.5374866261714 8.43578141822633e-10 MirTarget -0.653740531120143 1.45585236714297e-13 NA NA NA hsa-miR-146b-5p MYT1 2.23105707690238 3.83997814011313e-23 -0.563889323774597 0.251181740028895 miRNATAP -0.327974088339565 0.0074388056480712 NA NA NA hsa-miR-200b-3p MYT1 2.06025765178663 3.07718049337497e-10 -0.563889323774597 0.251181740028895 TargetScan -0.185860772502643 0.0362034243898411 NA NA NA hsa-miR-935 MYT1 2.321600496365 1.00042201726114e-07 -0.563889323774597 0.251181740028895 MirTarget;PITA;miRNATAP -0.267926706775435 0.000140758318707606 NA NA NA hsa-miR-21-5p N4BP2L1 2.21515015440792 6.0468197386674e-49 -0.643486455918364 2.53236501526357e-05 MirTarget -0.200231558114032 0.000124674280741127 NA NA NA hsa-miR-192-5p N4BP3 2.0867723747501 3.57854249239079e-08 -0.458519484573398 0.0212718067649276 mirMAP -0.156974283200046 3.27379533005986e-07 NA NA NA hsa-miR-335-3p NAALAD2 2.29463721765513 4.1956113745077e-18 -0.500152584470302 0.0206825509417707 MirTarget -0.152029183689243 0.00113091815262443 NA NA NA hsa-miR-141-5p NACC2 2.13747696823946 1.73124674554872e-11 -0.451762729052781 0.0126696300271997 mirMAP -0.339931398652875 1.11452240458264e-29 NA NA NA hsa-miR-200b-3p NACC2 2.06025765178663 3.07718049337497e-10 -0.451762729052781 0.0126696300271997 TargetScan -0.328920272002979 4.28994097935262e-29 NA NA NA hsa-miR-335-3p NACC2 2.29463721765513 4.1956113745077e-18 -0.451762729052781 0.0126696300271997 mirMAP -0.231147548283057 1.452577378079e-09 NA NA NA hsa-miR-92a-1-5p NACC2 2.04820501765632 9.32117486799495e-13 -0.451762729052781 0.0126696300271997 mirMAP -0.208587516530652 1.50471478334638e-08 NA NA NA hsa-miR-200b-3p NALCN 2.06025765178663 3.07718049337497e-10 1.06797485713514 0.00236792089085085 MirTarget -0.363883673106264 4.69941730630859e-09 NA NA NA hsa-miR-146b-5p NANOS1 2.23105707690238 3.83997814011313e-23 -0.224839937186315 0.081535141672364 miRanda -0.152570193898521 1.40639849987095e-06 NA NA NA hsa-miR-200b-3p NANOS1 2.06025765178663 3.07718049337497e-10 -0.224839937186315 0.081535141672364 TargetScan -0.130640511918575 7.76101203825853e-09 NA NA NA hsa-miR-135b-5p NAP1L2 2.80066701698235 2.12546333413447e-11 -2.67629782358685 5.25079284157108e-11 MirTarget -0.54055870047181 8.53115798380604e-21 NA NA NA hsa-miR-935 NAP1L2 2.321600496365 1.00042201726114e-07 -2.67629782358685 5.25079284157108e-11 MirTarget -0.50787406472279 6.7801737404679e-19 NA NA NA hsa-miR-200b-3p NAP1L5 2.06025765178663 3.07718049337497e-10 -1.21129186695927 2.52055289827296e-08 MirTarget -0.381389034661669 2.27784335635381e-25 NA NA NA hsa-miR-192-5p NAT8L 2.0867723747501 3.57854249239079e-08 -0.604016971759259 0.105753818729999 mirMAP -0.234720268684038 5.36247275180652e-05 NA NA NA hsa-miR-146b-3p NAV2 2.08650140817622 5.3293570720033e-22 -0.121843329970551 0.549053973627072 MirTarget;PITA;miRNATAP -0.242588518288349 3.36385896504615e-06 NA NA NA hsa-miR-146b-5p NAV2 2.23105707690238 3.83997814011313e-23 -0.121843329970551 0.549053973627072 PITA;miRanda -0.264587875985276 9.48714409461238e-08 NA NA NA hsa-miR-335-3p NAV2 2.29463721765513 4.1956113745077e-18 -0.121843329970551 0.549053973627072 mirMAP -0.185133269718093 1.99134161658004e-05 NA NA NA hsa-miR-200a-3p NAV3 2.02394729844446 2.21240501925011e-08 0.211655463277069 0.477292605948984 mirMAP -0.417890198238094 3.58184376397898e-20 NA NA NA hsa-miR-335-3p NAV3 2.29463721765513 4.1956113745077e-18 0.211655463277069 0.477292605948984 mirMAP -0.255957276005084 5.95115350234266e-05 NA NA NA hsa-miR-135b-5p NBEA 2.80066701698235 2.12546333413447e-11 -1.40726399632313 0.000274481542791401 MirTarget -0.462976923148208 1.00690394457837e-17 NA NA NA hsa-miR-18a-5p NBEA 2.04701000113742 1.30593450319289e-12 -1.40726399632313 0.000274481542791401 miRNAWalker2_validate -0.696223191532435 2.29949416984955e-21 NA NA NA hsa-miR-194-5p NBEA 2.24386881692218 9.35116329002209e-11 -1.40726399632313 0.000274481542791401 miRNATAP -0.499441229465113 2.27390060732006e-15 NA NA NA hsa-miR-21-5p NBEA 2.21515015440792 6.0468197386674e-49 -1.40726399632313 0.000274481542791401 miRNAWalker2_validate;miRNATAP -0.882548512742303 5.21258264448881e-12 NA NA NA hsa-miR-935 NBEA 2.321600496365 1.00042201726114e-07 -1.40726399632313 0.000274481542791401 miRNAWalker2_validate -0.472261757164365 3.25082672761729e-19 NA NA NA hsa-miR-200a-3p NBPF14 2.02394729844446 2.21240501925011e-08 0.230792359351786 0.108104640546555 MirTarget -0.113652160495291 9.08632396945757e-07 NA NA NA hsa-miR-146b-5p NCALD 2.23105707690238 3.83997814011313e-23 -0.877973466780329 0.000124467786873093 miRanda -0.348240964960705 5.15729072291341e-10 NA NA NA hsa-miR-200b-3p NCAM1 2.06025765178663 3.07718049337497e-10 -2.66813815810839 1.70378058404723e-12 TargetScan -0.683261356797174 4.74869679562918e-26 NA NA NA hsa-miR-335-3p NCAM1 2.29463721765513 4.1956113745077e-18 -2.66813815810839 1.70378058404723e-12 mirMAP -0.710259684444205 6.72312266273747e-19 NA NA NA hsa-miR-935 NCAM1 2.321600496365 1.00042201726114e-07 -2.66813815810839 1.70378058404723e-12 miRNATAP -0.438523245996048 4.60705434033029e-16 NA NA NA hsa-miR-183-5p NCAM2 2.08412478942637 1.08931431254487e-10 -0.482369705556969 0.225649283145191 MirTarget -0.598697286904153 1.24522105019764e-18 NA NA NA hsa-miR-335-3p NCAM2 2.29463721765513 4.1956113745077e-18 -0.482369705556969 0.225649283145191 mirMAP -0.343422671017312 5.69822751738781e-05 NA NA NA hsa-miR-146b-5p NCK2 2.23105707690238 3.83997814011313e-23 -0.324616221554267 0.0014983763943092 miRanda -0.164929035080711 2.24598649697957e-11 NA NA NA hsa-miR-335-3p NCKAP1L 2.29463721765513 4.1956113745077e-18 0.159605130924535 0.482185662845747 MirTarget -0.124521539665029 0.0110980645113173 NA NA NA hsa-miR-146b-3p NCKAP5 2.08650140817622 5.3293570720033e-22 -1.41048120959455 2.01051413732167e-08 MirTarget -0.175859438222088 0.00908917550977788 NA NA NA hsa-miR-335-3p NCKAP5 2.29463721765513 4.1956113745077e-18 -1.41048120959455 2.01051413732167e-08 MirTarget;mirMAP -0.130355701196974 0.0197926767839965 NA NA NA hsa-miR-1-3p NCL -2.73171785118192 3.4424534921136e-12 0.621580176092017 1.24583467512085e-11 MirTarget -0.122024757492165 1.41284435741759e-20 NA NA NA hsa-miR-146b-5p NCOA1 2.23105707690238 3.83997814011313e-23 -0.432339426210207 1.85810686450943e-06 miRanda -0.118695111428421 1.22223057010885e-07 NA NA NA hsa-miR-18a-5p NCOA1 2.04701000113742 1.30593450319289e-12 -0.432339426210207 1.85810686450943e-06 MirTarget;miRNATAP -0.126053418363647 1.66556795069436e-12 NA NA NA hsa-miR-183-5p NCS1 2.08412478942637 1.08931431254487e-10 -0.652620477793938 0.0278454371426777 MirTarget;miRNATAP -0.466958752818682 2.00390605083672e-20 NA NA NA hsa-miR-200b-3p NCS1 2.06025765178663 3.07718049337497e-10 -0.652620477793938 0.0278454371426777 TargetScan -0.558198966297297 9.2344830055105e-32 NA NA NA hsa-miR-192-5p NDE1 2.0867723747501 3.57854249239079e-08 -1.39508330784898 2.25855054668167e-05 miRNAWalker2_validate -0.539318434849762 8.43976039213558e-31 NA NA NA hsa-miR-146b-5p NDEL1 2.23105707690238 3.83997814011313e-23 -0.586753612423517 3.56373891666402e-12 PITA;miRanda -0.107187575699922 5.62543399861197e-07 NA NA NA hsa-miR-200b-3p NDN 2.06025765178663 3.07718049337497e-10 -1.37695704553379 3.45629342707931e-08 MirTarget;TargetScan -0.522912115238464 1.74992887131126e-39 NA NA NA hsa-miR-200a-3p NDNF 2.02394729844446 2.21240501925011e-08 -1.51391923305532 5.24454277418782e-05 MirTarget -0.35475963602175 5.11252784924823e-09 NA NA NA hsa-miR-200b-3p NDNF 2.06025765178663 3.07718049337497e-10 -1.51391923305532 5.24454277418782e-05 TargetScan -0.405458472066243 1.05157371455808e-09 NA NA NA hsa-miR-200b-3p NDST1 2.06025765178663 3.07718049337497e-10 -0.130588786602125 0.314387734671676 TargetScan -0.133836021928855 3.60941822425572e-09 NA NA NA hsa-miR-21-5p NDST1 2.21515015440792 6.0468197386674e-49 -0.130588786602125 0.314387734671676 mirMAP -0.14243312335645 0.00113524445559924 NA NA NA hsa-miR-146b-5p NECAB1 2.23105707690238 3.83997814011313e-23 -1.67514034579841 3.2768162361083e-06 MirTarget;miRanda -0.689794209506928 1.97075396977427e-15 NA NA NA hsa-miR-200a-3p NECAB1 2.02394729844446 2.21240501925011e-08 -1.67514034579841 3.2768162361083e-06 MirTarget -0.698655289691282 3.33339939557928e-42 NA NA NA hsa-miR-335-3p NECAB1 2.29463721765513 4.1956113745077e-18 -1.67514034579841 3.2768162361083e-06 MirTarget -0.69261700878392 4.6717440121466e-21 NA NA NA hsa-miR-92a-1-5p NECAB1 2.04820501765632 9.32117486799495e-13 -1.67514034579841 3.2768162361083e-06 MirTarget -0.710010450982995 2.20652925633885e-24 NA NA NA hsa-miR-18a-5p NEDD4 2.04701000113742 1.30593450319289e-12 0.020080909655646 0.898338965374599 MirTarget;miRNATAP -0.182760391702953 3.27915590199007e-09 NA NA NA hsa-miR-183-5p NEFL 2.08412478942637 1.08931431254487e-10 -2.70941382730451 8.31154823594214e-07 MirTarget -0.984515419102255 3.3645219973852e-26 NA NA NA hsa-miR-135b-5p NEFM 2.80066701698235 2.12546333413447e-11 -2.56160308758853 4.22329549085997e-09 MirTarget;miRNATAP -0.4637766791374 2.21352075124009e-13 NA NA NA hsa-miR-200b-3p NEGR1 2.06025765178663 3.07718049337497e-10 -2.01758948574649 3.53214332685673e-09 TargetScan -0.661584721763415 8.34578550967993e-32 NA NA NA hsa-miR-335-3p NEGR1 2.29463721765513 4.1956113745077e-18 -2.01758948574649 3.53214332685673e-09 mirMAP -0.689175193337452 9.13575245021952e-23 NA NA NA hsa-miR-192-5p NEK1 2.0867723747501 3.57854249239079e-08 -0.287505938477648 0.00657690319494584 miRNAWalker2_validate -0.145703314458412 2.47324899347785e-21 NA NA NA hsa-miR-21-5p NEK1 2.21515015440792 6.0468197386674e-49 -0.287505938477648 0.00657690319494584 miRNAWalker2_validate -0.131560282088985 0.000229334527223842 NA NA NA hsa-miR-335-3p NEK1 2.29463721765513 4.1956113745077e-18 -0.287505938477648 0.00657690319494584 mirMAP -0.126900314332625 1.31843701873111e-08 NA NA NA hsa-miR-200b-3p NEK10 2.06025765178663 3.07718049337497e-10 -0.78923113131067 7.03147924958596e-05 TargetScan -0.192478608164016 5.591593429512e-08 NA NA NA hsa-miR-146b-5p NEK9 2.23105707690238 3.83997814011313e-23 -0.112532343950376 0.296110755688608 miRanda -0.102405423906459 0.000111257064646167 NA NA NA hsa-miR-200b-3p NEK9 2.06025765178663 3.07718049337497e-10 -0.112532343950376 0.296110755688608 MirTarget;TargetScan -0.155410593546568 1.00557022924511e-17 NA NA NA hsa-miR-1-3p NETO2 -2.73171785118192 3.4424534921136e-12 1.45959194384399 3.48030283288339e-07 MirTarget -0.184314485606623 1.92555889160598e-05 NA NA NA hsa-miR-192-5p NEURL1B 2.0867723747501 3.57854249239079e-08 -0.0245660760020838 0.904340058133076 mirMAP -0.17380373820567 2.70719931724592e-08 NA NA NA hsa-miR-200a-3p NEURL1B 2.02394729844446 2.21240501925011e-08 -0.0245660760020838 0.904340058133076 mirMAP -0.203417485517098 3.65125582097987e-10 NA NA NA hsa-miR-146b-5p NFASC 2.23105707690238 3.83997814011313e-23 -1.21285969875073 0.000588897114251105 mirMAP;miRNATAP -0.50512864817899 5.53180354308707e-09 NA NA NA hsa-miR-18a-5p NFASC 2.04701000113742 1.30593450319289e-12 -1.21285969875073 0.000588897114251105 mirMAP -0.64756307145966 2.28559547315449e-22 NA NA NA hsa-miR-200a-3p NFASC 2.02394729844446 2.21240501925011e-08 -1.21285969875073 0.000588897114251105 MirTarget;miRNATAP -0.639158520145534 6.25917560703044e-36 NA NA NA hsa-miR-200b-3p NFASC 2.06025765178663 3.07718049337497e-10 -1.21285969875073 0.000588897114251105 TargetScan;mirMAP -0.684955870377482 8.99807161679891e-34 NA NA NA hsa-miR-194-5p NFAT5 2.24386881692218 9.35116329002209e-11 0.461239695424155 0.000656069696676909 miRNATAP -0.102068053263999 7.83952544867365e-06 NA NA NA hsa-miR-141-5p NFIA 2.13747696823946 1.73124674554872e-11 -0.546116799329663 0.00406390884761114 miRNATAP -0.326420447073293 5.41000841585941e-24 NA NA NA hsa-miR-200a-3p NFIA 2.02394729844446 2.21240501925011e-08 -0.546116799329663 0.00406390884761114 miRNATAP -0.24731980637515 5.88774744409905e-17 NA NA NA hsa-miR-200a-5p NFIA 2.19152245759943 3.17968183522514e-11 -0.546116799329663 0.00406390884761114 MirTarget;miRNATAP -0.2798384867171 1.44228286493589e-18 NA NA NA hsa-miR-200b-3p NFIA 2.06025765178663 3.07718049337497e-10 -0.546116799329663 0.00406390884761114 MirTarget;TargetScan -0.254040267632355 8.50776863154421e-15 NA NA NA hsa-miR-21-5p NFIA 2.21515015440792 6.0468197386674e-49 -0.546116799329663 0.00406390884761114 MirTarget;miRNATAP -0.314732787345326 8.22528816532692e-07 NA NA NA hsa-miR-335-3p NFIA 2.29463721765513 4.1956113745077e-18 -0.546116799329663 0.00406390884761114 MirTarget -0.210864914122732 1.95091517558394e-07 NA NA NA hsa-miR-935 NFIA 2.321600496365 1.00042201726114e-07 -0.546116799329663 0.00406390884761114 miRNATAP -0.204005740459501 7.01819266482882e-15 NA NA NA hsa-miR-200a-3p NFIB 2.02394729844446 2.21240501925011e-08 0.0225947120786127 0.907947126450015 mirMAP -0.113380962307182 0.00036325153974999 NA NA NA hsa-miR-200b-3p NFIB 2.06025765178663 3.07718049337497e-10 0.0225947120786127 0.907947126450015 TargetScan -0.115124416405723 0.000994512841781149 NA NA NA hsa-miR-135b-5p NFIC 2.80066701698235 2.12546333413447e-11 -0.525555953395095 0.000626295957247341 mirMAP -0.144815692657652 4.33491110210658e-11 NA NA NA hsa-miR-183-5p NFIC 2.08412478942637 1.08931431254487e-10 -0.525555953395095 0.000626295957247341 mirMAP -0.272466633917659 1.74589492638184e-26 NA NA NA hsa-miR-192-5p NFIC 2.0867723747501 3.57854249239079e-08 -0.525555953395095 0.000626295957247341 mirMAP -0.21403218123603 1.62998358871799e-21 NA NA NA hsa-miR-200b-3p NFIC 2.06025765178663 3.07718049337497e-10 -0.525555953395095 0.000626295957247341 TargetScan -0.243693173415379 4.13897936548959e-21 NA NA NA hsa-miR-21-5p NFIC 2.21515015440792 6.0468197386674e-49 -0.525555953395095 0.000626295957247341 mirMAP -0.243832887376893 2.55038508542561e-06 NA NA NA hsa-miR-92a-1-5p NFIC 2.04820501765632 9.32117486799495e-13 -0.525555953395095 0.000626295957247341 mirMAP -0.221311661448524 6.91239620309097e-13 NA NA NA hsa-miR-146b-5p NFIX 2.23105707690238 3.83997814011313e-23 -0.625715797314676 0.000190034636172099 mirMAP;miRNATAP -0.252446211877213 7.50478311611702e-10 NA NA NA hsa-miR-335-3p NFIX 2.29463721765513 4.1956113745077e-18 -0.625715797314676 0.000190034636172099 mirMAP -0.197317423505153 3.56799720783663e-08 NA NA NA hsa-miR-146b-5p NHLH2 2.23105707690238 3.83997814011313e-23 -1.13238804574205 0.0251840262570513 miRanda -0.568733195224939 5.34139284419226e-06 NA NA NA hsa-miR-146b-5p NHSL2 2.23105707690238 3.83997814011313e-23 -0.397340956842721 0.158978844057479 miRanda -0.303917977616615 1.24622973269588e-05 NA NA NA hsa-miR-183-5p NHSL2 2.08412478942637 1.08931431254487e-10 -0.397340956842721 0.158978844057479 miRNAWalker2_validate -0.497566645969317 1.34008425527034e-26 NA NA NA hsa-miR-146b-5p NID1 2.23105707690238 3.83997814011313e-23 0.00699907967043245 0.969397294350886 miRanda -0.193249900942287 1.65261205742264e-05 NA NA NA hsa-miR-335-3p NID1 2.29463721765513 4.1956113745077e-18 0.00699907967043245 0.969397294350886 mirMAP -0.15177367673062 0.000100339494834319 NA NA NA hsa-miR-192-5p NIN 2.0867723747501 3.57854249239079e-08 -0.252681320029704 0.137941934206193 miRNAWalker2_validate -0.24046897245338 1.35703690015093e-22 26743688 MiR 192 suppresses the tumorigenicity of prostate cancer cells by targeting and inhibiting nin one binding protein prostate cancer hsa-miR-21-5p NIN 2.21515015440792 6.0468197386674e-49 -0.252681320029704 0.137941934206193 miRNAWalker2_validate -0.131946661146631 0.0226486995763727 NA NA NA hsa-miR-335-3p NIN 2.29463721765513 4.1956113745077e-18 -0.252681320029704 0.137941934206193 mirMAP -0.204874361597464 1.15233788227037e-08 NA NA NA hsa-miR-146b-3p NIPAL3 2.08650140817622 5.3293570720033e-22 -0.452440485746727 1.87765980659022e-05 MirTarget -0.163684890660256 1.54240926832284e-09 NA NA NA hsa-miR-335-3p NIPAL3 2.29463721765513 4.1956113745077e-18 -0.452440485746727 1.87765980659022e-05 mirMAP -0.142947100420153 1.65291390456311e-10 NA NA NA hsa-miR-183-5p NIPAL4 2.08412478942637 1.08931431254487e-10 -2.09953954896125 2.4167868386351e-06 MirTarget -0.901006588840735 1.48741097482794e-35 NA NA NA hsa-miR-200b-3p NKD1 2.06025765178663 3.07718049337497e-10 -0.462280090506528 0.262062739608295 TargetScan -0.302543989129346 3.88399922641002e-05 NA NA NA hsa-miR-21-5p NKD1 2.21515015440792 6.0468197386674e-49 -0.462280090506528 0.262062739608295 mirMAP -0.519886059435425 0.000185654099592008 NA NA NA hsa-miR-18a-5p NKIRAS1 2.04701000113742 1.30593450319289e-12 -0.58839346780069 3.79446551367189e-06 MirTarget -0.202803988717821 2.46892780824188e-16 NA NA NA hsa-miR-21-5p NKIRAS1 2.21515015440792 6.0468197386674e-49 -0.58839346780069 3.79446551367189e-06 MirTarget -0.285430131044673 1.56976562678809e-11 NA NA NA hsa-miR-335-3p NKX2-2 2.29463721765513 4.1956113745077e-18 -3.07969852866339 2.40207556750811e-06 mirMAP -0.308426851613443 0.0325943102969658 NA NA NA hsa-miR-192-5p NKX3-1 2.0867723747501 3.57854249239079e-08 -0.537969900637996 0.0339763112751292 miRNAWalker2_validate -0.167683226505431 2.14868694894442e-05 NA NA NA hsa-miR-200a-5p NLGN1 2.19152245759943 3.17968183522514e-11 -2.68234371159062 4.2506090500709e-08 miRNATAP -0.817944618339912 2.32251004232005e-23 NA NA NA hsa-miR-200b-3p NLGN1 2.06025765178663 3.07718049337497e-10 -2.68234371159062 4.2506090500709e-08 mirMAP -0.8225111391295 5.55321672776285e-23 NA NA NA hsa-miR-335-3p NLGN1 2.29463721765513 4.1956113745077e-18 -2.68234371159062 4.2506090500709e-08 mirMAP -0.801019219608756 9.80933422068998e-15 NA NA NA hsa-miR-146b-5p NLGN3 2.23105707690238 3.83997814011313e-23 -0.461103847343634 0.046292443293039 miRanda -0.21904882433242 0.000134838067249635 NA NA NA hsa-miR-200b-3p NLGN4X 2.06025765178663 3.07718049337497e-10 -1.0328790909786 0.00177741749681608 TargetScan -0.452110876127727 2.00437539355395e-15 NA NA NA hsa-miR-194-5p NLGN4Y 2.24386881692218 9.35116329002209e-11 -0.845193725811185 0.318564940849564 MirTarget -0.456368149337741 0.00145885667911441 NA NA NA hsa-miR-335-3p NLRC3 2.29463721765513 4.1956113745077e-18 0.230716170992233 0.283859993025721 MirTarget -0.126398440105617 0.00651649103772802 NA NA NA hsa-miR-196a-5p NME4 5.05945965885472 4.48343841468539e-25 -0.821346536763786 5.56908356193717e-05 miRNATAP -0.14310842129766 5.61141598713426e-10 NA NA NA hsa-miR-196b-5p NME4 4.51951031652328 7.04026169031626e-18 -0.821346536763786 5.56908356193717e-05 MirTarget;miRNATAP -0.13034159609522 2.35729741304235e-09 NA NA NA hsa-miR-200a-3p NMNAT2 2.02394729844446 2.21240501925011e-08 -0.342534844271856 0.286507478799891 miRNATAP -0.332772352214577 6.63744053017353e-11 NA NA NA hsa-miR-335-3p NMNAT2 2.29463721765513 4.1956113745077e-18 -0.342534844271856 0.286507478799891 mirMAP -0.260548636925865 0.000158124582928793 NA NA NA hsa-miR-92a-1-5p NMNAT2 2.04820501765632 9.32117486799495e-13 -0.342534844271856 0.286507478799891 mirMAP -0.278440665540253 2.45937426896849e-05 NA NA NA hsa-miR-146b-5p NODAL 2.23105707690238 3.83997814011313e-23 0.196558886050585 0.524400798215979 miRanda -0.282107455210528 0.000223105535410493 NA NA NA hsa-miR-200b-3p NOG 2.06025765178663 3.07718049337497e-10 -0.00525322557399677 0.988813892893077 MirTarget;TargetScan -0.476852456289133 1.37552568171658e-13 NA NA NA hsa-miR-935 NOL4 2.321600496365 1.00042201726114e-07 -1.20414809765101 0.021926100473984 MirTarget;PITA;miRNATAP -0.278607759471159 0.000228579275648148 NA NA NA hsa-miR-135b-5p NOS1 2.80066701698235 2.12546333413447e-11 -2.96330117656761 1.10501685397827e-08 mirMAP -0.663635575590644 1.18064691229334e-19 NA NA NA hsa-miR-146b-5p NOS1 2.23105707690238 3.83997814011313e-23 -2.96330117656761 1.10501685397827e-08 mirMAP;miRNATAP -1.06479243294269 2.01545476142878e-17 NA NA NA hsa-miR-200a-5p NOS1 2.19152245759943 3.17968183522514e-11 -2.96330117656761 1.10501685397827e-08 mirMAP -0.900718397865112 2.26181789205547e-25 NA NA NA hsa-miR-335-3p NOS1 2.29463721765513 4.1956113745077e-18 -2.96330117656761 1.10501685397827e-08 mirMAP -0.941874365096785 3.5204940938789e-18 NA NA NA hsa-miR-92a-1-5p NOS1 2.04820501765632 9.32117486799495e-13 -2.96330117656761 1.10501685397827e-08 mirMAP -0.961545878568081 9.6202712437914e-21 NA NA NA hsa-miR-935 NOS1 2.321600496365 1.00042201726114e-07 -2.96330117656761 1.10501685397827e-08 mirMAP -0.548828324772191 8.97034337589985e-14 NA NA NA hsa-miR-183-5p NOTCH2 2.08412478942637 1.08931431254487e-10 0.138226358603258 0.351625722215957 miRNAWalker2_validate -0.173408604692044 2.67870355809377e-11 NA NA NA hsa-miR-200a-5p NOTCH2 2.19152245759943 3.17968183522514e-11 0.138226358603258 0.351625722215957 mirMAP -0.17340439050175 7.70990950432947e-12 NA NA NA hsa-miR-335-3p NOV 2.29463721765513 4.1956113745077e-18 -0.579522371724216 0.0467562198476761 MirTarget;mirMAP -0.307616756081757 7.26804370898592e-07 NA NA NA hsa-miR-146b-5p NOVA1 2.23105707690238 3.83997814011313e-23 -2.03955007528378 1.32480844598322e-07 PITA;miRanda;miRNATAP -0.590582442295558 7.67542300372069e-10 26673617 NOVA1 inhibition by miR 146b 5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal; NOVA1 a target gene of miR-146b-5p was decreased in remnant tissues of patients with a poor prognosis; In vitro analysis showed that the NOVA1 gene was inhibited by miR-146b-5p; In immune cells as well as stromal spindle cells decreased NOVA1 possibly inhibited by miR-146b-5p is a candidate biomarker predicting poor prognosis of gastric cancer patients and is also a biomarker of occult residual disease in remnant tissues after gastric cancer removal worse prognosis gastric cancer hsa-miR-200a-5p NOVA1 2.19152245759943 3.17968183522514e-11 -2.03955007528378 1.32480844598322e-07 miRNATAP -0.71236555347629 1.62364789012745e-29 NA NA NA hsa-miR-200b-3p NOVA1 2.06025765178663 3.07718049337497e-10 -2.03955007528378 1.32480844598322e-07 MirTarget;TargetScan -0.695593910747403 4.88643859510498e-27 NA NA NA hsa-miR-183-5p NOVA2 2.08412478942637 1.08931431254487e-10 0.42427201532203 0.00657550941360171 mirMAP -0.116851076862794 3.57154742025357e-05 NA NA NA hsa-miR-200b-3p NOVA2 2.06025765178663 3.07718049337497e-10 0.42427201532203 0.00657550941360171 TargetScan -0.13549802722943 1.05845164426748e-06 NA NA NA hsa-miR-146b-5p NOX5 2.23105707690238 3.83997814011313e-23 -1.24313570007306 0.000197120564586901 miRanda;mirMAP -0.406205438247817 9.58972195177134e-07 NA NA NA hsa-miR-146b-5p NPAS3 2.23105707690238 3.83997814011313e-23 -1.3039423495911 3.14871409441284e-05 PITA;miRanda -0.44941512722509 6.11645930786106e-09 NA NA NA hsa-miR-183-5p NPAS3 2.08412478942637 1.08931431254487e-10 -1.3039423495911 3.14871409441284e-05 miRNATAP -0.592793185229165 2.09484080816394e-30 NA NA NA hsa-miR-196a-5p NPAS3 5.05945965885472 4.48343841468539e-25 -1.3039423495911 3.14871409441284e-05 miRNATAP -0.210873090532558 3.35616823586954e-09 NA NA NA hsa-miR-196b-5p NPAS3 4.51951031652328 7.04026169031626e-18 -1.3039423495911 3.14871409441284e-05 miRNATAP -0.219655230223207 4.71571888197608e-11 NA NA NA hsa-miR-200a-3p NPAS3 2.02394729844446 2.21240501925011e-08 -1.3039423495911 3.14871409441284e-05 miRNATAP -0.475630169760649 3.41427629512628e-23 NA NA NA hsa-miR-21-5p NPAS3 2.21515015440792 6.0468197386674e-49 -1.3039423495911 3.14871409441284e-05 miRNATAP -0.526511974399154 7.16781795249791e-07 NA NA NA hsa-miR-146b-5p NPAS4 2.23105707690238 3.83997814011313e-23 -2.30750138379934 2.74899554053868e-07 PITA;miRNATAP -0.857350855234363 3.46124638785123e-15 NA NA NA hsa-miR-192-5p NPHP3 2.0867723747501 3.57854249239079e-08 -0.51989084361666 0.000175333522053114 miRNAWalker2_validate -0.154073648131723 2.07502939099699e-13 NA NA NA hsa-miR-200a-5p NPHP3 2.19152245759943 3.17968183522514e-11 -0.51989084361666 0.000175333522053114 MirTarget -0.173660478643903 2.96762715030858e-13 NA NA NA hsa-miR-335-3p NPPC 2.29463721765513 4.1956113745077e-18 -2.98938931814775 1.11312189266726e-09 MirTarget -0.6931089677243 6.41036171173561e-11 NA NA NA hsa-miR-146b-5p NPR2 2.23105707690238 3.83997814011313e-23 -0.246876604888241 0.131595693244826 miRanda -0.19159598658928 1.84770967834389e-06 NA NA NA hsa-miR-146b-5p NPR3 2.23105707690238 3.83997814011313e-23 -1.50737055199652 6.49105069424171e-05 miRanda;miRNATAP -0.551897633697176 2.8373436349592e-09 NA NA NA hsa-miR-335-3p NPR3 2.29463721765513 4.1956113745077e-18 -1.50737055199652 6.49105069424171e-05 MirTarget;mirMAP -0.435921375169497 7.40646526252749e-08 NA NA NA hsa-miR-200a-3p NPTX1 2.02394729844446 2.21240501925011e-08 -2.73557408094059 1.52696712035104e-06 miRNATAP -0.957853961701207 4.16034355028144e-29 NA NA NA hsa-miR-200b-3p NPTX1 2.06025765178663 3.07718049337497e-10 -2.73557408094059 1.52696712035104e-06 TargetScan -1.06059722801479 1.00674568689959e-29 NA NA NA hsa-miR-192-5p NPTXR 2.0867723747501 3.57854249239079e-08 -1.00186986119569 0.00367721137641764 miRNAWalker2_validate -0.429750733853547 5.78344228820466e-17 NA NA NA hsa-miR-200a-3p NPTXR 2.02394729844446 2.21240501925011e-08 -1.00186986119569 0.00367721137641764 mirMAP -0.531634917171368 1.87709064978816e-24 NA NA NA hsa-miR-18a-5p NR1H2 2.04701000113742 1.30593450319289e-12 -0.501916780342478 2.54191671981354e-07 miRNATAP -0.128978229023972 2.72186535066658e-11 NA NA NA hsa-miR-194-5p NR2F2 2.24386881692218 9.35116329002209e-11 -0.138727905922965 0.397897286244025 miRNATAP -0.122220336039421 8.40505503936481e-06 NA NA NA hsa-miR-935 NR2F2 2.321600496365 1.00042201726114e-07 -0.138727905922965 0.397897286244025 miRNAWalker2_validate;miRNATAP -0.120710377240753 1.85903370611349e-07 NA NA NA hsa-miR-183-5p NR3C1 2.08412478942637 1.08931431254487e-10 -0.898894495561724 5.37287634787075e-07 miRNATAP -0.318008732608707 1.11641214171696e-25 NA NA NA hsa-miR-18a-5p NR3C1 2.04701000113742 1.30593450319289e-12 -0.898894495561724 5.37287634787075e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.311367913026351 2.38499830124315e-19 NA NA NA hsa-miR-200b-3p NR3C1 2.06025765178663 3.07718049337497e-10 -0.898894495561724 5.37287634787075e-07 TargetScan -0.296748234046349 1.59926226265969e-22 NA NA NA hsa-miR-335-3p NR3C2 2.29463721765513 4.1956113745077e-18 -1.56039614446023 3.73297616519859e-10 mirMAP -0.311097792709821 1.08231159444793e-08 NA NA NA hsa-miR-335-3p NR4A3 2.29463721765513 4.1956113745077e-18 -1.38493152893107 4.8630804857497e-06 mirMAP -0.370285163363445 1.30030746886441e-08 NA NA NA hsa-miR-192-5p NREP 2.0867723747501 3.57854249239079e-08 0.530509207259767 0.00332033398775606 miRNAWalker2_validate -0.186658776770056 1.0471573749702e-11 NA NA NA hsa-miR-200b-3p NREP 2.06025765178663 3.07718049337497e-10 0.530509207259767 0.00332033398775606 TargetScan -0.216247817654621 6.63413892669662e-12 NA NA NA hsa-miR-146b-5p NRG1 2.23105707690238 3.83997814011313e-23 -2.26620872793921 8.78733696739752e-09 miRanda -0.387954294213362 0.000112205654907023 NA NA NA hsa-miR-146b-5p NRG3 2.23105707690238 3.83997814011313e-23 -1.83639414814974 3.88872265837504e-05 miRanda -0.700662496362347 1.5167022368389e-10 NA NA NA hsa-miR-335-3p NRG4 2.29463721765513 4.1956113745077e-18 -2.10807656811435 1.18562070455812e-11 MirTarget -0.345201710994451 5.31476695242523e-07 NA NA NA hsa-miR-183-5p NRIP2 2.08412478942637 1.08931431254487e-10 -0.223754773452244 0.187987129155073 MirTarget -0.259519534191786 2.52487336364381e-19 NA NA NA hsa-miR-146b-5p NRIP3 2.23105707690238 3.83997814011313e-23 0.160905136200642 0.500759938594481 miRanda;mirMAP -0.211029218748148 0.000362129003771207 NA NA NA hsa-miR-200a-3p NRIP3 2.02394729844446 2.21240501925011e-08 0.160905136200642 0.500759938594481 MirTarget -0.228505140464431 1.985864578192e-09 NA NA NA hsa-miR-200b-3p NRIP3 2.06025765178663 3.07718049337497e-10 0.160905136200642 0.500759938594481 mirMAP -0.245958073876785 4.25164549945635e-09 NA NA NA hsa-miR-196a-5p NRK 5.05945965885472 4.48343841468539e-25 0.655919808675683 0.192167140385376 miRNATAP -0.117221177367541 0.0436637432215506 NA NA NA hsa-miR-196b-5p NRK 4.51951031652328 7.04026169031626e-18 0.655919808675683 0.192167140385376 miRNATAP -0.182602337824046 0.000797242555141444 NA NA NA hsa-miR-335-3p NRK 2.29463721765513 4.1956113745077e-18 0.655919808675683 0.192167140385376 MirTarget;mirMAP -0.303182111853556 0.00528075353286767 NA NA NA hsa-miR-335-3p NRN1 2.29463721765513 4.1956113745077e-18 -1.23764786730415 4.27902002062013e-06 mirMAP -0.367095397741565 1.60144397977543e-10 NA NA NA hsa-miR-194-5p NRP1 2.24386881692218 9.35116329002209e-11 0.575916847809068 0.000209823999859742 miRNATAP -0.122248668629287 3.19156239645638e-06 NA NA NA hsa-miR-200a-3p NRP1 2.02394729844446 2.21240501925011e-08 0.575916847809068 0.000209823999859742 miRNATAP -0.15831469464361 2.15826796559945e-10 NA NA NA hsa-miR-146b-3p NRP2 2.08650140817622 5.3293570720033e-22 -0.239503242524362 0.327696709683055 PITA;miRNATAP -0.302535920317664 1.44765785852696e-06 NA NA NA hsa-miR-146b-5p NRP2 2.23105707690238 3.83997814011313e-23 -0.239503242524362 0.327696709683055 PITA;miRanda;miRNATAP -0.357819542083963 1.58842162462703e-09 NA NA NA hsa-miR-183-5p NRP2 2.08412478942637 1.08931431254487e-10 -0.239503242524362 0.327696709683055 miRNATAP -0.42913521831121 2.53660174874545e-26 NA NA NA hsa-miR-200a-3p NRP2 2.02394729844446 2.21240501925011e-08 -0.239503242524362 0.327696709683055 miRNATAP -0.450227393353086 1.50130883389759e-38 NA NA NA hsa-miR-200b-3p NRP2 2.06025765178663 3.07718049337497e-10 -0.239503242524362 0.327696709683055 TargetScan -0.486339113816061 6.17474436248232e-37 NA NA NA hsa-miR-200a-3p NRSN2 2.02394729844446 2.21240501925011e-08 -0.0686184477529626 0.749830761095627 MirTarget -0.182390967816872 1.28628359244738e-07 NA NA NA hsa-miR-141-5p NRXN1 2.13747696823946 1.73124674554872e-11 -3.77804960296992 8.78046893071678e-12 MirTarget -1.03891208821507 4.88853350238324e-27 NA NA NA hsa-miR-196a-5p NRXN1 5.05945965885472 4.48343841468539e-25 -3.77804960296992 8.78046893071678e-12 miRNAWalker2_validate;miRNATAP -0.449557239374727 2.00569876084534e-12 NA NA NA hsa-miR-196b-5p NRXN1 4.51951031652328 7.04026169031626e-18 -3.77804960296992 8.78046893071678e-12 miRNATAP -0.412902499953854 8.47294244290284e-12 NA NA NA hsa-miR-200a-3p NRXN1 2.02394729844446 2.21240501925011e-08 -3.77804960296992 8.78046893071678e-12 MirTarget;miRNATAP -0.876664408668923 5.64633924863527e-24 NA NA NA hsa-miR-335-3p NRXN1 2.29463721765513 4.1956113745077e-18 -3.77804960296992 8.78046893071678e-12 MirTarget;mirMAP -1.02458163526685 2.03451718018099e-18 NA NA NA hsa-miR-183-5p NRXN3 2.08412478942637 1.08931431254487e-10 -0.893042446799847 0.0418559410066107 miRNATAP -0.812425606229126 1.11606988737994e-29 NA NA NA hsa-miR-335-3p NRXN3 2.29463721765513 4.1956113745077e-18 -0.893042446799847 0.0418559410066107 mirMAP -0.554976209013777 2.03344875926876e-09 NA NA NA hsa-miR-141-5p NT5DC3 2.13747696823946 1.73124674554872e-11 0.603797740800287 0.00453248132523208 mirMAP -0.261252473672514 6.30417287035436e-12 NA NA NA hsa-miR-192-5p NT5M 2.0867723747501 3.57854249239079e-08 -0.674854777150096 0.000470914802451387 miRNAWalker2_validate -0.15088109445808 4.96880207248029e-07 NA NA NA hsa-miR-200b-3p NTF3 2.06025765178663 3.07718049337497e-10 -1.52188285755702 4.13580352197116e-07 TargetScan -0.168627433095034 0.00227099339738329 NA NA NA hsa-miR-21-5p NTF3 2.21515015440792 6.0468197386674e-49 -1.52188285755702 4.13580352197116e-07 miRTarBase;miRNATAP -0.741062168553893 1.15482809906199e-13 NA NA NA hsa-miR-146b-3p NTN1 2.08650140817622 5.3293570720033e-22 -2.06447596754744 1.49348953834274e-09 mirMAP -0.606504516783994 7.95943511923787e-12 NA NA NA hsa-miR-183-5p NTN4 2.08412478942637 1.08931431254487e-10 -0.966087576866514 1.08550650388992e-06 MirTarget -0.28170620644654 6.70899340610949e-16 NA NA NA hsa-miR-196a-5p NTN4 5.05945965885472 4.48343841468539e-25 -0.966087576866514 1.08550650388992e-06 MirTarget -0.124054900499925 5.17627162302528e-08 24120501 miR 196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells; Only netrin 4 NTN4 expression displayed an inverse association with miR-196a; Fluorescent reporter assays revealed that miR-196a inhibited NTN4 expression by targeting one binding site in the 3'-untranslated region 3'-UTR of NTN4 mRNA; Furthermore qPCR and Western blot assays verified NTN4 expression was downregulated in cervical cancer tissues compared to normal controls and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression cervical and endocervical cancer hsa-miR-196b-5p NTN4 4.51951031652328 7.04026169031626e-18 -0.966087576866514 1.08550650388992e-06 MirTarget -0.167453641392902 8.41450861076044e-16 NA NA NA hsa-miR-335-3p NTN4 2.29463721765513 4.1956113745077e-18 -0.966087576866514 1.08550650388992e-06 mirMAP -0.289900663353867 5.49168600477635e-12 NA NA NA hsa-miR-135b-5p NTNG1 2.80066701698235 2.12546333413447e-11 -1.90178300776111 5.11283394122196e-05 MirTarget -0.469217969283749 3.060734213379e-12 NA NA NA hsa-miR-141-5p NTNG1 2.13747696823946 1.73124674554872e-11 -1.90178300776111 5.11283394122196e-05 MirTarget -0.808280737830817 1.27316273971989e-23 NA NA NA hsa-miR-335-3p NTNG1 2.29463721765513 4.1956113745077e-18 -1.90178300776111 5.11283394122196e-05 mirMAP -0.616287711328195 7.1574753352619e-10 NA NA NA hsa-miR-146b-5p NTRK2 2.23105707690238 3.83997814011313e-23 -0.735609554829713 0.0649549334443704 PITA;miRanda -0.44988387933958 4.70575212047044e-06 NA NA NA hsa-miR-21-5p NTRK2 2.21515015440792 6.0468197386674e-49 -0.735609554829713 0.0649549334443704 mirMAP -0.499987201642294 0.000207874296830454 NA NA NA hsa-miR-335-3p NTRK2 2.29463721765513 4.1956113745077e-18 -0.735609554829713 0.0649549334443704 mirMAP -0.284037225247794 0.000958592457033415 NA NA NA hsa-miR-135b-5p NTRK3 2.80066701698235 2.12546333413447e-11 -1.77034455288451 2.67480607357566e-05 mirMAP -0.463015875623264 1.01739262700969e-14 NA NA NA hsa-miR-146b-5p NTRK3 2.23105707690238 3.83997814011313e-23 -1.77034455288451 2.67480607357566e-05 miRanda;mirMAP -0.49800088153653 2.20661416069355e-06 NA NA NA hsa-miR-18a-5p NTRK3 2.04701000113742 1.30593450319289e-12 -1.77034455288451 2.67480607357566e-05 mirMAP -0.701625749137849 7.02735882792981e-18 NA NA NA hsa-miR-192-5p NTRK3 2.0867723747501 3.57854249239079e-08 -1.77034455288451 2.67480607357566e-05 mirMAP -0.470538945594709 2.45914664265974e-13 NA NA NA hsa-miR-194-5p NTRK3 2.24386881692218 9.35116329002209e-11 -1.77034455288451 2.67480607357566e-05 mirMAP -0.4580067023451 7.14983510974895e-11 NA NA NA hsa-miR-200a-3p NTRK3 2.02394729844446 2.21240501925011e-08 -1.77034455288451 2.67480607357566e-05 mirMAP -0.584811762082533 5.39984164561327e-19 NA NA NA hsa-miR-200a-5p NTRK3 2.19152245759943 3.17968183522514e-11 -1.77034455288451 2.67480607357566e-05 mirMAP -0.617443044462936 5.75941863284648e-18 NA NA NA hsa-miR-21-5p NTRK3 2.21515015440792 6.0468197386674e-49 -1.77034455288451 2.67480607357566e-05 mirMAP -0.72747768816018 3.52839203773143e-07 NA NA NA hsa-miR-335-3p NTRK3 2.29463721765513 4.1956113745077e-18 -1.77034455288451 2.67480607357566e-05 mirMAP -0.47113508818831 2.12873843377045e-07 NA NA NA hsa-miR-192-5p NUCKS1 2.0867723747501 3.57854249239079e-08 0.325102076142334 0.00397222584600734 miRNAWalker2_validate -0.100907081276142 5.22903704582695e-09 NA NA NA hsa-miR-21-5p NUDT16 2.21515015440792 6.0468197386674e-49 -0.474980214956483 8.12535859145524e-06 mirMAP -0.174957130638885 1.19127314862713e-06 NA NA NA hsa-miR-133a-3p NUP160 -2.63342156915404 5.72661351480585e-12 0.709347446433635 1.24224946414503e-12 MirTarget -0.113410523357055 9.03023420071958e-14 NA NA NA hsa-miR-146b-5p NWD1 2.23105707690238 3.83997814011313e-23 -1.34360716988962 0.000473823953066612 miRanda -0.409976394062952 1.87849910084275e-05 NA NA NA hsa-miR-1-3p NXT2 -2.73171785118192 3.4424534921136e-12 0.648386435023641 1.23632413901883e-05 MirTarget -0.175138840224653 1.1478288796368e-16 NA NA NA hsa-miR-200b-3p NYAP1 2.06025765178663 3.07718049337497e-10 -1.17961202441282 0.000226776631096157 MirTarget;TargetScan -0.328720135513019 7.32370338061405e-09 NA NA NA hsa-miR-192-5p OGFRL1 2.0867723747501 3.57854249239079e-08 -0.44512577168017 0.0218904834741364 miRNAWalker2_validate -0.197906981761335 1.81249494965369e-11 NA NA NA hsa-miR-146b-5p OGN 2.23105707690238 3.83997814011313e-23 -1.91781397932278 0.000338785010402909 miRanda -0.72235656430884 4.48635291131549e-08 NA NA NA hsa-miR-146b-5p OLFM1 2.23105707690238 3.83997814011313e-23 -1.29294356020994 2.57354229549415e-06 miRanda -0.38308278143984 2.02913621629023e-08 NA NA NA hsa-miR-200a-3p OLFM1 2.02394729844446 2.21240501925011e-08 -1.29294356020994 2.57354229549415e-06 MirTarget;miRNATAP -0.30558095524006 5.04158150569865e-12 NA NA NA hsa-miR-18a-5p OLFML2A 2.04701000113742 1.30593450319289e-12 -0.285533571299206 0.12295215646008 mirMAP -0.237624780626903 5.33712085260427e-11 NA NA NA hsa-miR-200a-3p OLFML2A 2.02394729844446 2.21240501925011e-08 -0.285533571299206 0.12295215646008 mirMAP -0.238827571891465 7.395233766462e-17 NA NA NA hsa-miR-92a-1-5p OLFML2A 2.04820501765632 9.32117486799495e-13 -0.285533571299206 0.12295215646008 mirMAP -0.159363109752638 2.76681430008805e-05 NA NA NA hsa-miR-146b-5p OMD 2.23105707690238 3.83997814011313e-23 -0.693507143547008 0.103815999498164 miRanda -0.39170996428824 0.000212937960421971 NA NA NA hsa-miR-194-5p OPCML 2.24386881692218 9.35116329002209e-11 -2.49847614950772 3.51349456819977e-14 miRNATAP -0.321314005420773 2.44383098064193e-08 NA NA NA hsa-miR-196a-5p OPCML 5.05945965885472 4.48343841468539e-25 -2.49847614950772 3.51349456819977e-14 miRNATAP -0.251367571699926 8.2077141990522e-11 NA NA NA hsa-miR-196b-5p OPCML 4.51951031652328 7.04026169031626e-18 -2.49847614950772 3.51349456819977e-14 miRNATAP -0.202842309422651 3.8996563534309e-08 NA NA NA hsa-miR-200a-5p OPCML 2.19152245759943 3.17968183522514e-11 -2.49847614950772 3.51349456819977e-14 mirMAP -0.333564351290526 3.32704327007045e-08 NA NA NA hsa-miR-335-3p OPCML 2.29463721765513 4.1956113745077e-18 -2.49847614950772 3.51349456819977e-14 mirMAP -0.523412858190405 3.3661162950717e-13 NA NA NA hsa-miR-935 OPCML 2.321600496365 1.00042201726114e-07 -2.49847614950772 3.51349456819977e-14 mirMAP -0.197129367292472 7.2220306477577e-05 NA NA NA hsa-miR-146b-3p OPRD1 2.08650140817622 5.3293570720033e-22 -0.37963997741805 0.482095045621834 MirTarget -0.546334999931385 9.18791004758905e-05 NA NA NA hsa-miR-18a-5p ORAI3 2.04701000113742 1.30593450319289e-12 -0.256859678793534 0.0350545934554395 miRNAWalker2_validate;miRNATAP -0.156742473553751 4.68488003226778e-11 NA NA NA hsa-miR-146b-5p OSBPL1A 2.23105707690238 3.83997814011313e-23 -1.05361282706133 2.95872705953644e-08 miRanda -0.32425487169328 4.30844479986855e-12 NA NA NA hsa-miR-21-5p OSBPL1A 2.21515015440792 6.0468197386674e-49 -1.05361282706133 2.95872705953644e-08 miRNAWalker2_validate -0.411861019921473 1.38017574843007e-10 NA NA NA hsa-miR-192-5p OSBPL6 2.0867723747501 3.57854249239079e-08 -1.15327659051427 2.95657055047018e-06 miRNAWalker2_validate -0.370562627152088 7.40825407149164e-25 NA NA NA hsa-miR-200a-3p OSBPL6 2.02394729844446 2.21240501925011e-08 -1.15327659051427 2.95657055047018e-06 MirTarget;miRNATAP -0.335001555324547 5.10263227263215e-18 NA NA NA hsa-miR-200b-3p OSBPL6 2.06025765178663 3.07718049337497e-10 -1.15327659051427 2.95657055047018e-06 mirMAP -0.372305880130735 1.70015942539889e-18 NA NA NA hsa-miR-21-5p OSBPL6 2.21515015440792 6.0468197386674e-49 -1.15327659051427 2.95657055047018e-06 mirMAP -0.518521246738908 3.88499781221647e-10 NA NA NA hsa-miR-335-3p OSBPL6 2.29463721765513 4.1956113745077e-18 -1.15327659051427 2.95657055047018e-06 mirMAP -0.386996176020785 9.18262961103331e-14 NA NA NA hsa-miR-935 OSBPL6 2.321600496365 1.00042201726114e-07 -1.15327659051427 2.95657055047018e-06 PITA;miRNATAP -0.217362716780102 6.68225699145286e-10 NA NA NA hsa-miR-133a-3p OSCAR -2.63342156915404 5.72661351480585e-12 1.22113032069097 1.03967937465596e-08 MirTarget -0.115276214378527 0.000571550174811272 NA NA NA hsa-miR-200b-3p OSMR 2.06025765178663 3.07718049337497e-10 1.07319248891458 2.03893889502661e-07 TargetScan -0.1694133215127 6.55580706775718e-06 NA NA NA hsa-miR-200b-3p OSR1 2.06025765178663 3.07718049337497e-10 -0.914235079349368 0.011234198005583 TargetScan -0.381757575805446 1.8160415914766e-09 NA NA NA hsa-miR-21-5p OSR1 2.21515015440792 6.0468197386674e-49 -0.914235079349368 0.011234198005583 miRNAWalker2_validate;MirTarget;miRNATAP -0.485551851015141 6.93760637786918e-05 NA NA NA hsa-miR-146b-3p OSTM1 2.08650140817622 5.3293570720033e-22 -0.246334914419587 0.0298039433570488 miRNATAP -0.10372254907537 0.000412029127776394 NA NA NA hsa-miR-194-5p OSTM1 2.24386881692218 9.35116329002209e-11 -0.246334914419587 0.0298039433570488 MirTarget -0.163835527771473 5.18614735653442e-20 NA NA NA hsa-miR-200b-3p OSTM1 2.06025765178663 3.07718049337497e-10 -0.246334914419587 0.0298039433570488 MirTarget;TargetScan -0.205134337444651 3.29953474911774e-29 NA NA NA hsa-miR-146b-3p OXR1 2.08650140817622 5.3293570720033e-22 -0.258588395599566 0.0253350483547519 PITA -0.171048639544987 5.72100662870941e-09 NA NA NA hsa-miR-200a-3p P2RX6 2.02394729844446 2.21240501925011e-08 -0.983059548344933 0.00329537992813149 mirMAP -0.349789732920786 5.84028909485839e-11 NA NA NA hsa-miR-196a-5p P2RY1 5.05945965885472 4.48343841468539e-25 -1.19639573973956 7.7759186703287e-06 MirTarget -0.124972813063693 5.76575461000218e-05 NA NA NA hsa-miR-196b-5p P2RY1 4.51951031652328 7.04026169031626e-18 -1.19639573973956 7.7759186703287e-06 MirTarget -0.108569009842619 0.000219825642197897 NA NA NA hsa-miR-335-3p P2RY13 2.29463721765513 4.1956113745077e-18 -0.478354693549255 0.0518540610009183 mirMAP -0.176567901758021 0.000875801715924956 NA NA NA hsa-miR-335-3p PABPC4L 2.29463721765513 4.1956113745077e-18 -0.143166439410341 0.546975666393986 MirTarget -0.31589660050497 2.08995740461108e-10 NA NA NA hsa-miR-335-3p PABPC5 2.29463721765513 4.1956113745077e-18 -0.631345013039332 0.0172608282080574 mirMAP -0.405028555911054 1.85503996570418e-13 NA NA NA hsa-miR-194-5p PACSIN1 2.24386881692218 9.35116329002209e-11 -0.616906534590458 0.0649579908947998 mirMAP -0.160504720666066 0.00469843787188239 NA NA NA hsa-miR-141-5p PAFAH1B1 2.13747696823946 1.73124674554872e-11 -0.429125161604443 1.79547396100101e-08 miRNATAP -0.108704393073045 1.13844155409039e-15 NA NA NA hsa-miR-18a-5p PAFAH1B1 2.04701000113742 1.30593450319289e-12 -0.429125161604443 1.79547396100101e-08 miRNAWalker2_validate -0.111849021108107 8.99612519803754e-14 NA NA NA hsa-miR-194-5p PAIP2 2.24386881692218 9.35116329002209e-11 -0.514527553538336 2.05179039015577e-08 MirTarget -0.161568328788487 6.51779873838342e-30 NA NA NA hsa-miR-200b-3p PAIP2 2.06025765178663 3.07718049337497e-10 -0.514527553538336 2.05179039015577e-08 MirTarget;TargetScan -0.1669100829357 4.91219253660578e-28 NA NA NA hsa-miR-141-5p PAIP2B 2.13747696823946 1.73124674554872e-11 -2.12606281275216 2.98300604290892e-11 mirMAP -0.240058224249487 8.17307374761811e-05 NA NA NA hsa-miR-146b-5p PAIP2B 2.23105707690238 3.83997814011313e-23 -2.12606281275216 2.98300604290892e-11 mirMAP -0.581811852184328 2.42005349352535e-13 NA NA NA hsa-miR-21-5p PAIP2B 2.21515015440792 6.0468197386674e-49 -2.12606281275216 2.98300604290892e-11 miRNATAP -0.764105775646485 2.01850445964503e-12 NA NA NA hsa-miR-146b-3p PAK3 2.08650140817622 5.3293570720033e-22 -0.628036493389936 0.0725313783898835 MirTarget;miRNATAP -0.25404311558227 0.00539887199857917 NA NA NA hsa-miR-146b-5p PAK3 2.23105707690238 3.83997814011313e-23 -0.628036493389936 0.0725313783898835 miRanda -0.326687947688576 0.000166325681670004 NA NA NA hsa-miR-200b-3p PAK3 2.06025765178663 3.07718049337497e-10 -0.628036493389936 0.0725313783898835 TargetScan -0.373652609833614 1.11036978399302e-09 NA NA NA hsa-miR-196a-5p PALLD 5.05945965885472 4.48343841468539e-25 -0.733799109511982 0.0016821174230045 miRNAWalker2_validate -0.180362145576339 4.64648676311079e-12 NA NA NA hsa-miR-21-5p PALLD 2.21515015440792 6.0468197386674e-49 -0.733799109511982 0.0016821174230045 miRNAWalker2_validate -0.462238934492261 2.86411397374222e-09 NA NA NA hsa-miR-200a-3p PALM2-AKAP2 2.02394729844446 2.21240501925011e-08 -0.288031326259333 0.0858840552909669 miRNATAP -0.258010165332311 9.43339440953313e-25 NA NA NA hsa-miR-200a-5p PALM2-AKAP2 2.19152245759943 3.17968183522514e-11 -0.288031326259333 0.0858840552909669 mirMAP -0.273917163496759 1.2994469015636e-23 NA NA NA hsa-miR-200b-3p PALM2-AKAP2 2.06025765178663 3.07718049337497e-10 -0.288031326259333 0.0858840552909669 TargetScan -0.282318027114935 1.43597581154505e-24 NA NA NA hsa-miR-141-5p PAM 2.13747696823946 1.73124674554872e-11 -0.213715233670169 0.151419217579645 MirTarget -0.257798167007186 8.14433485005108e-25 NA NA NA hsa-miR-146b-5p PAM 2.23105707690238 3.83997814011313e-23 -0.213715233670169 0.151419217579645 miRanda -0.175737780256849 1.48435902934682e-06 NA NA NA hsa-miR-183-5p PAM 2.08412478942637 1.08931431254487e-10 -0.213715233670169 0.151419217579645 MirTarget;miRNATAP -0.212309152409998 1.0253121458715e-16 NA NA NA hsa-miR-200b-3p PAM 2.06025765178663 3.07718049337497e-10 -0.213715233670169 0.151419217579645 TargetScan -0.206106868007026 4.1650250888171e-16 NA NA NA hsa-miR-335-3p PAM 2.29463721765513 4.1956113745077e-18 -0.213715233670169 0.151419217579645 mirMAP -0.154149124356287 1.09893950840183e-06 NA NA NA hsa-miR-200b-3p PAPLN 2.06025765178663 3.07718049337497e-10 -0.548479264272031 0.0280496512763077 TargetScan -0.363893775761635 8.92742975312923e-18 NA NA NA hsa-miR-18a-5p PAPPA 2.04701000113742 1.30593450319289e-12 -0.147868440566481 0.520876658558301 miRNATAP -0.134421809642794 0.00384255169916875 NA NA NA hsa-miR-200a-3p PAPPA 2.02394729844446 2.21240501925011e-08 -0.147868440566481 0.520876658558301 MirTarget;miRNATAP -0.156534970544067 2.76991145874171e-05 NA NA NA hsa-miR-335-3p PAPPA 2.29463721765513 4.1956113745077e-18 -0.147868440566481 0.520876658558301 MirTarget;mirMAP -0.18328618283551 0.000205999381325126 NA NA NA hsa-miR-146b-5p PAPPA2 2.23105707690238 3.83997814011313e-23 -1.97606049061529 6.84108269241418e-06 miRanda -0.59751815853138 4.35388018428424e-08 NA NA NA hsa-miR-200a-3p PAQR7 2.02394729844446 2.21240501925011e-08 -0.975901595966971 2.67579726524356e-08 MirTarget -0.110037112669045 0.000177249611228919 NA NA NA hsa-miR-200b-3p PARD3B 2.06025765178663 3.07718049337497e-10 -0.127470625293643 0.42618046220041 MirTarget;TargetScan;mirMAP -0.162298802006921 7.25494256556626e-09 NA NA NA hsa-miR-146b-5p PARD6G 2.23105707690238 3.83997814011313e-23 -0.654930910231291 0.000320115632596957 miRanda -0.262405078930729 4.13035989079849e-09 NA NA NA hsa-miR-146b-5p PARK2 2.23105707690238 3.83997814011313e-23 -1.89244050972141 3.57297597227642e-13 miRanda -0.618027506816831 5.56954688672559e-23 NA NA NA hsa-miR-335-3p PARK2 2.29463721765513 4.1956113745077e-18 -1.89244050972141 3.57297597227642e-13 mirMAP -0.513704282322299 6.25331470748353e-21 NA NA NA hsa-miR-335-3p PARM1 2.29463721765513 4.1956113745077e-18 -0.747387248962458 0.00361191987642478 mirMAP -0.313789662365591 8.51639235199848e-09 NA NA NA hsa-miR-935 PARM1 2.321600496365 1.00042201726114e-07 -0.747387248962458 0.00361191987642478 mirMAP -0.218537260083778 1.65590964096516e-09 NA NA NA hsa-miR-335-3p PARP8 2.29463721765513 4.1956113745077e-18 -0.283388913919174 0.0304372520864017 mirMAP -0.106494772292475 0.000150042287550616 NA NA NA hsa-miR-194-5p PARVA 2.24386881692218 9.35116329002209e-11 -0.476179816551364 0.00428675171134699 MirTarget -0.238853750554729 2.21476616366923e-19 NA NA NA hsa-miR-335-3p PARVA 2.29463721765513 4.1956113745077e-18 -0.476179816551364 0.00428675171134699 MirTarget -0.283829377809089 9.80580170876208e-17 NA NA NA hsa-miR-335-3p PAX6 2.29463721765513 4.1956113745077e-18 -0.444286149214719 0.0468893513390666 mirMAP -0.103829652320607 0.0323239848005768 25323813 microRNA 335 inhibits proliferation cell cycle progression colony formation and invasion via targeting PAX6 in breast cancer cells; Luciferase reporter assays identified the paired box 6 gene PAX6 as a novel target of miR-335; Further investigation revealed that miR-335 negatively regulates the expression of PAX6 in human breast cancer MCF-7 cells; Our results further suggested that overexpression of miR-335 inhibits MCF-7 cell proliferation by inducing cell-cycle arrest at the G1 phase via targeting PAX6; Furthermore miR-335 overexpression reduced colony formation and cellular invasion in MCF-7 cells an effect that was reversed by PAX6 overexpression progression breast cancer hsa-miR-196a-5p PBX1 5.05945965885472 4.48343841468539e-25 -1.20575316450853 1.28079310379343e-07 MirTarget;miRNATAP -0.152377957197665 6.54404880653397e-09 NA NA NA hsa-miR-196b-5p PBX1 4.51951031652328 7.04026169031626e-18 -1.20575316450853 1.28079310379343e-07 MirTarget;miRNATAP -0.157941274737687 1.36470916443799e-10 NA NA NA hsa-miR-21-5p PBX1 2.21515015440792 6.0468197386674e-49 -1.20575316450853 1.28079310379343e-07 miRNAWalker2_validate -0.616000869238203 2.36239792296251e-16 NA NA NA hsa-miR-335-3p PBX1 2.29463721765513 4.1956113745077e-18 -1.20575316450853 1.28079310379343e-07 mirMAP -0.329927368413448 1.3000861541432e-11 NA NA NA hsa-miR-196a-5p PBX3 5.05945965885472 4.48343841468539e-25 -0.281102097769818 0.131536814716469 miRNATAP -0.140421315604885 1.11568697237649e-11 NA NA NA hsa-miR-196b-5p PBX3 4.51951031652328 7.04026169031626e-18 -0.281102097769818 0.131536814716469 miRNATAP -0.141254159209872 3.15239517403198e-13 NA NA NA hsa-miR-200b-3p PBX3 2.06025765178663 3.07718049337497e-10 -0.281102097769818 0.131536814716469 TargetScan -0.374622355506081 5.26518166211916e-38 NA NA NA hsa-miR-335-3p PBX3 2.29463721765513 4.1956113745077e-18 -0.281102097769818 0.131536814716469 mirMAP -0.218545676635909 2.84279542013565e-08 NA NA NA hsa-miR-200b-3p PCDH10 2.06025765178663 3.07718049337497e-10 -1.64405177074991 0.00780146459503323 MirTarget -1.08396363457261 1.20879216098426e-26 NA NA NA hsa-miR-935 PCDH10 2.321600496365 1.00042201726114e-07 -1.64405177074991 0.00780146459503323 MirTarget;PITA -0.595886523315624 4.95703043673035e-12 NA NA NA hsa-miR-200a-3p PCDH17 2.02394729844446 2.21240501925011e-08 0.730714992703952 1.70412772811198e-05 miRNATAP -0.101170999074153 0.00032000340417128 NA NA NA hsa-miR-335-3p PCDH18 2.29463721765513 4.1956113745077e-18 0.216017523004449 0.24644931172572 mirMAP -0.124697010735656 0.0018844921697072 NA NA NA hsa-miR-183-5p PCDH19 2.08412478942637 1.08931431254487e-10 -1.82078557875039 1.37631334790411e-08 mirMAP -0.440915198085305 1.39915577457738e-14 NA NA NA hsa-miR-192-5p PCDH19 2.0867723747501 3.57854249239079e-08 -1.82078557875039 1.37631334790411e-08 miRNATAP -0.326068524424544 7.43444355945389e-11 NA NA NA hsa-miR-196a-5p PCDH19 5.05945965885472 4.48343841468539e-25 -1.82078557875039 1.37631334790411e-08 miRNATAP -0.172720190068958 4.12467798995973e-06 NA NA NA hsa-miR-196b-5p PCDH19 4.51951031652328 7.04026169031626e-18 -1.82078557875039 1.37631334790411e-08 miRNATAP -0.160704834213661 5.64855439889849e-06 NA NA NA hsa-miR-200b-3p PCDH19 2.06025765178663 3.07718049337497e-10 -1.82078557875039 1.37631334790411e-08 TargetScan -0.433530495548917 1.98139817101367e-14 NA NA NA hsa-miR-192-5p PCDH7 2.0867723747501 3.57854249239079e-08 -0.826841168363386 0.0134942869816737 miRNAWalker2_validate -0.38329800947266 2.40150372192992e-14 NA NA NA hsa-miR-200b-3p PCDH7 2.06025765178663 3.07718049337497e-10 -0.826841168363386 0.0134942869816737 TargetScan -0.507314214211285 2.95237817766257e-19 NA NA NA hsa-miR-935 PCDH7 2.321600496365 1.00042201726114e-07 -0.826841168363386 0.0134942869816737 PITA -0.224559278444193 2.61953695737666e-06 NA NA NA hsa-miR-200a-3p PCDH8 2.02394729844446 2.21240501925011e-08 -0.996776255196674 0.0536605014298841 miRNAWalker2_validate;miRNATAP -0.296196334766945 0.000458396100351949 NA NA NA hsa-miR-200b-3p PCDH8 2.06025765178663 3.07718049337497e-10 -0.996776255196674 0.0536605014298841 TargetScan -0.32201277305269 0.000521644821152421 NA NA NA hsa-miR-146b-5p PCDH9 2.23105707690238 3.83997814011313e-23 -1.82279707707595 3.76874897040946e-05 miRanda -0.694689515489248 1.47752906775031e-10 NA NA NA hsa-miR-192-5p PCDH9 2.0867723747501 3.57854249239079e-08 -1.82279707707595 3.76874897040946e-05 MirTarget -0.611615861292133 7.93514913519726e-21 NA NA NA hsa-miR-200a-3p PCDH9 2.02394729844446 2.21240501925011e-08 -1.82279707707595 3.76874897040946e-05 MirTarget;miRNATAP -0.721205453327013 2.37473036628773e-27 NA NA NA hsa-miR-335-3p PCDH9 2.29463721765513 4.1956113745077e-18 -1.82279707707595 3.76874897040946e-05 mirMAP -0.808038305900041 5.37600641228128e-19 NA NA NA hsa-miR-335-3p PCDHAC2 2.29463721765513 4.1956113745077e-18 -0.527421449979268 0.137809971002795 MirTarget -0.366683073449082 1.2712282764446e-06 NA NA NA hsa-miR-18a-5p PCDHGC5 2.04701000113742 1.30593450319289e-12 -0.372355148345583 0.0402547159589238 mirMAP -0.304135821626951 1.08211907320781e-18 NA NA NA hsa-miR-146b-5p PCLO 2.23105707690238 3.83997814011313e-23 -1.84298625507284 0.000638908244587425 PITA;miRanda -0.829021175760896 3.21945243653457e-10 NA NA NA hsa-miR-200b-3p PCMTD1 2.06025765178663 3.07718049337497e-10 -0.481814036975657 7.02844288535814e-05 MirTarget;TargetScan -0.128642069845803 1.96865670417849e-09 NA NA NA hsa-miR-335-3p PCMTD1 2.29463721765513 4.1956113745077e-18 -0.481814036975657 7.02844288535814e-05 MirTarget -0.16763397364808 5.50089453565583e-11 NA NA NA hsa-miR-146b-5p PCOLCE2 2.23105707690238 3.83997814011313e-23 -2.53758318917856 3.21821768315232e-08 miRanda -0.637547069454469 2.98657895482399e-08 NA NA NA hsa-miR-192-5p PCOLCE2 2.0867723747501 3.57854249239079e-08 -2.53758318917856 3.21821768315232e-08 miRNAWalker2_validate -0.520585350450961 1.92890703023688e-13 NA NA NA hsa-miR-146b-5p PCSK2 2.23105707690238 3.83997814011313e-23 -4.70473903822062 1.0090814029853e-15 miRanda -1.1897752020586 5.18838355374476e-16 NA NA NA hsa-miR-200b-3p PCSK2 2.06025765178663 3.07718049337497e-10 -4.70473903822062 1.0090814029853e-15 TargetScan -0.840836317011267 2.56964323402735e-15 NA NA NA hsa-miR-335-3p PCSK2 2.29463721765513 4.1956113745077e-18 -4.70473903822062 1.0090814029853e-15 MirTarget -1.02362671293916 9.147566910524e-16 NA NA NA hsa-miR-146b-5p PCYOX1 2.23105707690238 3.83997814011313e-23 -0.358488256924208 0.000634769673819883 miRanda -0.192202683576856 1.57469558110626e-14 NA NA NA hsa-miR-135b-5p PCYT1B 2.80066701698235 2.12546333413447e-11 -0.268047509296331 0.526376797711269 miRNATAP -0.288446585706382 2.43578909764214e-06 NA NA NA hsa-miR-146b-3p PCYT1B 2.08650140817622 5.3293570720033e-22 -0.268047509296331 0.526376797711269 miRNATAP -0.467514957340746 1.82188454544806e-05 NA NA NA hsa-miR-196a-5p PCYT1B 5.05945965885472 4.48343841468539e-25 -0.268047509296331 0.526376797711269 miRNATAP -0.125589150022775 0.00991047249198645 NA NA NA hsa-miR-196b-5p PCYT1B 4.51951031652328 7.04026169031626e-18 -0.268047509296331 0.526376797711269 miRNATAP -0.171694610857448 0.000167283938617609 NA NA NA hsa-miR-21-5p PDCD4 2.21515015440792 6.0468197386674e-49 -0.887849040960037 3.08157230271797e-09 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.226453919888007 1.22571285440319e-05 22212233;20372781;23888942;24659669;25575817;25316501;22072622;22267128;22322403;19836969;23604124;25520758;19682430;23272133;25477028;26252635;25994220;25991676;22747440;23827854;23824073;24865582;24902663;24888238;24149370;20978511;17991735;22689922;27355932;19308091;24331411;26169933;22547075;23558936;23201752;20815812;17968323;25310697;21842656;23567619;20581857;23548551;19013014;21685938;26142886;24472409;25973032;26418978;22086602;26212010;25543482;25543261;23904372;27725205;23564788;25400316;26150475;21546206;19509156;27035745;23052036;22353043;19633292;25566594;21412018;19276261;21330826;26864640;22335905;21636706 PDCD4 expression inversely correlated with miR 21 levels in gastric cancers;Clinicopathological and prognostic significance of PDCD4 and microRNA 21 in human gastric cancer; Recent studies have demonstrated that the novel tumor suppressor protein programmed cell death 4 PDCD4 is downregulated in several human solid cancer types and is suppressed by microRNA-21 miR-21; The objectives of this study were: i to establish the clinicopathological and prognostic significance of PDCD4 mRNA and ii to elucidate any correlation between PDCD4 mRNA and miR-21 in gastric cancer; We also performed an association study comparing PDCD4 mRNA and miR-21 in eight cell lines and 49 gastric cancers; An inverse correlation between PDCD4 mRNA and miR-21 was found in gastric cancer; Furthermore our findings suggest that PDCD4 mRNA is negatively regulated by miR-21 in gastric cancer and may serve as a target for effective therapies;Oxidative stress upregulates PDCD4 expression in patients with gastric cancer via miR 21; The expression of miR-21 and PDCD4 was highly correlated with the degree of differentiation tumor staging local lymphatic node metastasis and remote metastasis; In addition the relative expression of PDCD4 was negatively correlated with miR-21; Thus we conclude that ROS promotes gastric carcinogenesis via upregulating miR-21 expression which in turn down-regulates the expression of PDCD4 in gastric cancer cells;The protein levels of miR-21 targets PTEN and PDCD4 were estimated; In the control experiment miR-21 mimic significantly inhibited the expression of PTEN and PDCD4 proteins in the two gastric cell lines leading to an increase in cell invasion and migration; miR-21 is overexpressed in gastric cancer and its aberrant expression may have important role in gastric cancer growth and dissemination by modulating the expression of the tumor suppressors PTEN and PDCD4 as well as by modulating the pathways involved in mediating cell growth migration invasion and apoptosis;We identified miR-21 was directly downregulated by RBP2 and found that miR-21 downregulated PDCD4 expression in leukemia cells;MTCs were consistently associated with miR-21 up-regulation P < .0016 and featured significant PDCD4 nuclear down-regulation; An inverse correlation emerged between miR-21 overexpression and PDCD4 down-regulation P = .0013; This study showed in MTCs that miR-21 regulates PDCD4 expression and also that the miR-21/PDCD4 pathway correlates with clinicopathological variables and prognosis;Although microRNA-21 miR-21 is emerging as an oncogene and has been shown to target several tumor suppressor genes including programmed cell death 4 PDCD4 its precise mechanism of action on cancer stem cells CSCs is unclear; Herein we report that FOLFOX-resistant HCT-116 and HT-29 cells that are enriched in CSCs show a 3- to 7-fold upregulation of pre- and mature miR-21 and downregulation of PDCD4; Likewise overexpression of miR-21 in HCT-116 cells achieved through stable transfection led to the downregulation of PDCD4 and transforming growth factor beta receptor 2 TGFβR2;Prognostic significance of PDCD4 expression and association with microRNA 21 in each Dukes' stage of colorectal cancer patients; Furthermore relationships between the PDCD4 mRNA and microRNA-21 miR-21 were evaluated; The PDCD4 mRNA was investigated by the quantitative real-time RT-PCR method and miR-21 was examined by TaqMan microRNA assays; Significant inverse correlations were demonstrated between PDCD4 and miR-21;miR 21 promotes migration and invasion by the miR 21 PDCD4 AP 1 feedback loop in human hepatocellular carcinoma; The expression level of miR-21 was inversely correlated with the protein expression level of a previously identified target gene programmed cell death 4 PDCD4;This short review will focus on our recent finding that the microRNA miR-21 posttranscriptionally regulates Pdcd4 as well as invasion intravasation and metastasis;HBx mediated miR 21 upregulation represses tumor suppressor function of PDCD4 in hepatocellular carcinoma; HBx downregulates PDCD4 expression at least partially through miR-21; Taken together this study reported for the first time that HBx downregulates PDCD4 and upregulates miR-21 expression; The deregulation of PDCD4 by HBx through miR-21 represents a potential novel mechanism of the downregulation of PDCD4 in HBV-related HCC and provides new insights into HCC development;MicroRNA 21 Down regulates Rb1 Expression by Targeting PDCD4 in Retinoblastoma; MicroRNA-21 miR-21 possesses the oncogenic potential to target several tumor suppressor genes including PDCD4 and regulates tumor progression and metastasis; However the mechanism of how miR-21 regulates PDCD4 is poorly understood in RB; Using the TargetScan program we identified a list of potential target genes of these miRNAs of which PDCD4 is one the targets of miR-21; In this study we focused on the regulatory mechanism of miR-21 on PDCD4 in RB; We demonstrated an inverse correlation between miR-21 and PDCD4 expression in Weri-Rb1 and Y79 cells; These data suggest that miR-21 down-regulates Rb1 by targeting PDCD4 tumor suppressor;MicroRNA 21 promotes cell proliferation and down regulates the expression of programmed cell death 4 PDCD4 in HeLa cervical carcinoma cells; In this study we found that the inhibition of miR-21 in HeLa cervical cancer cells caused profound suppression of cell proliferation and up-regulated the expression of the tumor suppressor gene PDCD4;Additionally resveratrol increased the expression of tumor suppressors PDCD4 and maspin which are negatively regulated by miR-21; Short interfering si RNA against PDCD4 attenuated resveratrol's effect on prostate cancer cells and similar effects were observed following over expression of miR-21 with pre-miR-21 oligonucleotides; MiR-21 expression in these cells appeared to be dependent on Akt as LY294002 reduced the levels of miR-21 along with a concurrent increase in PDCD4 expression; These tumor- and metastatic-suppressive effects of resveratrol were associated with reduced miR-21 and pAkt and elevated PDCD4 levels;The expression of miR-21 and PDCD4 mRNA in transfected cells was quantified by real-time polymerase chain reaction and the expression of PDCD4 protein by Western blot; Cell proliferation apoptosis migration and invasion assays were performed to determine the biological effects of miR-21 expression and PDCD4 inhibition; Co-transfection of miR-21-sponge with PDCD4 siRNA upregulated miR-21 expression in these cells; PDCD4 mRNA and protein levels were increased 2.14-fold and 2.16-fold respectively following inhibition of miR-21 expression; Depletion of PDCD4 by siRNA transfection reversed the reduction of cell proliferation migration and invasion induced by inhibition of miR-21 in A549 cells; It indicates that miR-21 is highly expressed in patients with NSCLC and inhibition of miR-21 expression reduces proliferation migration and invasion of A549 cells by upregulating PDCD4 expression; Modulation of miR-21 or PDCD4 expression may provide a potentially novel therapeutic approach for NSCLC;IL 6 Inhibits the Targeted Modulation of PDCD4 by miR 21 in Prostate Cancer; In this study we evaluated the role of IL-6 in PDCD4 gene expression and how the microRNA miR-21 regulates this process in prostate cancer cell lines PC-3 and LNCaP; The expression of PDCD4 was inhibited by IL-6 but this effect was weakened in cell lines with low expression of miR-21; These findings support the feasibility of future efforts for diagnosis and gene therapy for prostate cancer that are based on IL-6 miR-21 and PDCD4;Furthermore the absence of miR-21 increased the expression of its target gene PDCD4 and subsequently modulated nuclear factor NF-κB activation;In this study using reverse phase protein arrays RPPAs we assessed MPS1 mediated cell signaling pathways and demonstrated that inhibiting MPS1 could upregulate the expression of the tumor suppressor PDCD4 and MSH2 genes by down regulating micro RNA-21 miR-21; We also show the prognostic effect of miR21 PDCD4 and MSH2 levels to patient survival across different GBM molecular subtypes;We also analyzed the immunohistochemical expression of PDCD4 an miR-21 gene target; PDCD4 expression was significantly downregulated in MTC samples consistent with miR-21 upregulation;Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA 21 mediated programmed cell death 4 PDCD4 expression; Further AR inhibition also increased PDCD4 a putative target of miR-21 in human colon cancer cells; Collectively these results indicate that AR inhibition prevents growth factor-induced colon cancer growth by down-regulating miR-21 expression and increasing PDCD4 levels through the reactive oxygen species ROS/AMPK/mTOR/AP1/4E-BP1 pathway;Berberine could inhibit miR-21 expression and function in ovarian cancer as shown by an enhancement of its target PDCD4 an important tumor suppressor in ovarian cancer;Overexpression of miR-21 in cisplatin sensitive cells decreased PDCD4 levels and increased cell proliferation;MicroRNA 21 miR 21 post transcriptionally downregulates tumor suppressor PDCD4 and promotes cell transformation proliferation and metastasis in renal cell carcinoma; MiR-21 induces neoplastic transformation cell proliferation and metastasis and downregulates programmed cell death4 PDCD4 in some cancers; The aim of this study was to investigate the roles and interactions of PDCD4 and miR-21 in human renal cell carcinoma RCC; The expression levels of PDCD4 protein and mRNA and miR-21 were examined by Western blot analysis and by qRT-PCR and luciferase reporter assays; MiR-21 not only promoted cancer cell hyperplasia and contributed to tumor cell transformation and metastasis but also post-transcriptionally downregulated PDCD4 protein expression; PDCD4 and miR-21 expression levels potentially play an important role in renal cell cancer;Programmed cell death 4 PDCD4 is a tumor suppressor gene whose expression is directly controlled by microRNA-21 miR-21; This PDCD4 and miR-21 inverse expression was also noted in cells and exosomes from OSC peritoneal effusions compared with nonneoplastic effusions; PDCD4 and miR-21 are involved in OSC oncogenesis;Finally in a subgroup of tumor specimens ROC curve analysis performed on quantitative PCR data sets for miR-21 ITGβ4 and PDCD4 shows that the combination of high miR-21 with low ITGβ4 and PDCD4 expression is able to predict presence of metastasis; In conclusion miR-21 is a key player in oncogenic EMT its overexpression is controlled by the cooperation of genetic and epigenetic alterations and its levels along with ITGβ4 and PDCD4 expression could be exploited as a prognostic tool for CRC metastasis;Transfection of anti-miR-21 rendered HCC cells sensitive to IFN-α/5-FU and such sensitivity was weakened by transfection of siRNAs of target molecules PETN and PDCD4 miR-21 expression in clinical HCC specimens was significantly associated with the clinical response to the IFN-α/5-FU combination therapy and survival rate;Programmed cell death 4 PDCD4 is an important functional target of the microRNA miR 21 in breast cancer cells;In ZD esophagus and tongue oncogenic miR-31 and miR-21 overexpression was accompanied by down-regulation of their respective tumor-suppressor targets PPP2R2A and PDCD4;Due to inhibition of miR-21 expression of the programed cell death 4 PDCD4 gene was promoted in tumors resulting in the induction of apoptosis of tumor cells;We also demonstrated that BMP-6-induced downregulation of miR-21 modified the activity of PDCD4 3'UTR and inhibited MDA-MB-231 cell invasion;The level of miR-21 was reversely correlated with the expression of PTEN and PDCD4 and positive correlated with PI3K/Akt pathway; miR-21 is involved in acquired resistance of EGFR-TKI in NSCLC which is mediated by down-regulating PTEN and PDCD4 and activating PI3K/Akt pathway;The results indicated that the miR-21 inhibition could induce the cell cycle arrest in G1 phase upregulate the expression of Programmed Cell Death Protein 4 PDCD4 and thus active the caspase-3 apoptosis pathway;Induction of miR-21 may enable cancer cells to elude DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repressing expression of PTEN and PDCD4;Furthermore miR-21 mimic or inhibitor significantly reduced or increased the expression of PDCD4 and TPM1; MiR-21 is overexpressed in RCC tissue and modulates the growth apoptosis and cell cycle progression of RCC cells and regulates the expression of PDCD4 and TPM1;Moreover we demonstrate that oligonucleotide-mediated miR-21 silencing in U87 human GBM cells resulted in increased levels of the tumor suppressors PTEN and PDCD4 caspase 3/7 activation and decreased tumor cell proliferation;Curcumin treatment reduced miR-21 promoter activity and expression in a dose-dependent manner by inhibiting AP-1 binding to the promoter and induced the expression of the tumour suppressor Pdcd4 programmed cell death protein 4 which is a target of miR-21; Taken together this is the first paper to show that curcumin inhibits the transcriptional regulation of miR-21 via AP-1 suppresses cell proliferation tumour growth invasion and in vivo metastasis and stabilizes the expression of the tumour suppressor Pdcd4 in colorectal cancer;MicroRNA 21 miR 21 post transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion intravasation and metastasis in colorectal cancer; This is the first study to show that Pdcd4 is negatively regulated by miR-21;Inflammation and MiR 21 pathways functionally interact to downregulate PDCD4 in colorectal cancer; These findings indicate that miR-21 is a component of the COX-2 inflammation pathway and that this pathway promotes worsening of disease stage in colorectal cancer by inducing accumulation of PGE2 and increasing expression of miR-21 with consequent downregulation of the tumour suppressor gene PDCD4;The expression of miR-21 PTEN and PDCD4 were determined by Real-time PCR; Glossy ganoderma spore oil down-regulated the expression of miR-21 and up-regulated the expression of PTEN and PDCD4 significantly;Interestingly NVP-LDE-225 induced PDCD4 and apoptosis and inhibited cell viability by suppressing miR-21;PDCD4 a direct target gene of miR-21 could mediate chemoresistance to docetaxel in PC3 cells;Moreover knockdown of miR-21 increased PDCD4 and PTEN expression at the protein level but not at the mRNA level;MicroRNA 21 down regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G; Expression of PDCD4 protein correlates inversely with expression of miR-21 in a number of human glioblastoma cell lines such as T98G A172 U87 and U251; Inhibition of miR-21 increases endogenous levels of PDCD4 in cell line T98G and over-expression miR-21 inhibits PDCD4-dependent apoptosis;Treatment of HSC-3 cells with Nanog- and/or Stat-3-specific small interfering RNAs effectively blocks HA-mediated Nanog-Stat-3 signaling events abrogates miR-21 production and increases PDCD4 expression;Programmed cell death 4 PDCD4 is critical in mediating apoptosis in GBM and is downregulated by miR-21 which may mediate the resistance of glioblastoma cells against chemotherapy or radiation via its target genes PDCD4; This review will focus on the roles of miRNAs family members particularly miR-21 and its target gene PDCD4 in tumors like glioblastoma and new targeting strategies as examples some new targeting therapeutic methods and molecular mechanisms of signal pathways in glioblastoma therapeutics to give the reader the current trends of approach to target regulation of these miRNA and genes for future glioma therapies;Using Western blot analysis miR-21 knockdown enhanced the expression of tumor suppressor PDCD4 and attenuated apoptosis inhibitor c-IAP2;PDCD4 and PTEN expression was decreased gradually after tumor induction and negatively correlated with miR-21 expression; Our in vivo experiments further confirmed that miR-21 plays an important role in promoting the occurrence and development of HCC by regulating PDCD4 and PTEN;METHODS 3-45-dimethylthiazol-2-yl-25-diphenyltetrazolium bromide MTT assay was used to determine the effect of 5-FU on the viability of RKO cells with knockout of miR-21 or high expression of PDCD4;The effects were accompanied by up-regulation of tumor suppressor PDCD4 a known miR-21 target; as well as up-regulation of cofilin and profilin two key proteins involved in actin polymerization and cytoskeleton maintenance as a consequence of miR-182 down-regulation;Increased levels of miR-21 in turn downregulate the expression of the metastasis-suppressor protein programmed cell death 4 PDCD4 a validated miR-21 target;Moreover knockdown of miR-21 increased the expressions of PDCD4 and PTEN at the protein level but not at the mRNA level;In this study we analyzed the expression of miR-21 and of its target PDCD4 Programmed Cell Death 4 during normal hematopoietic differentiation and in AMLs;MiR 21 mediates the radiation resistance of glioblastoma cells by regulating PDCD4 and hMSH2; In addition miR-21 knockdown increased the expression of endogenous PDCD4 and hMSH2 which contributed to the apoptosis and G2 arrest of T98G cells; The findings suggested that miR-21 may mediate the resistance of glioblastoma cells against radiation via its target genes PDCD4 and hMSH2;The results showed that upon exposure to mUA miR-21 expression was decreased and the expression of PTEN and Pdcd4 protein was elevated;The expression of programmed cell death-4 PDCD4 was increased by I3C and reduced by miR-21 transfection; Such enhanced chemosensitivity might be explained by the increased expression of PDCD4 which is a downstream target which miR-21 negatively regulates;It has been reported that miR-21 was upregulated in most malignant cancers the proposed mechanism of which was through suppressing expression of programmed cell death 4 PDCD4; In present study it is firstly reported that miR-21 was upregulated in Kazakh's ESCC and that miR-21 played a negative role in regulating PDCD4 using in situ hybridization ISH and luciferase reporter approach;To measure levels of microRNA miR-21 and its target gene programmed cell death 4 PDCD4 in samples of human cutaneous malignant melanoma and normal non-malignant control skin; Relative levels of miR-21 and PDCD4 mRNA were measured using a quantitative real-time reverse transcription-polymerase chain reaction; Compared with normal skin samples the relative level of miR-21 was significantly higher and the relative level of PDCD4 mRNA was significantly lower in the melanoma specimens; A significant negative correlation between PDCD4 mRNA and miR-21 was demonstrated in malignant melanoma r = -0.602; Elevated miR-21 and reduced PDCD4 mRNA levels were both significantly correlated with increased tumour size a higher Clark classification level and the presence of lymph node metastases in malignant melanoma; These findings suggest that miR-21 and PDCD4 might be potential biomarkers for malignant melanoma and might provide treatment targets in the future;MicroRNA 21 and PDCD4 expression in colorectal cancer; Studies have shown that miR-21 exerts its oncogenic activity by targeting the PDCD4 tumour suppressor 3'-UTR; The purpose of this study was to delineate the interaction between PDCD4 and its oncogenic modulator miR-21 in colorectal cancer; A cohort of 48 colorectal tumours 61 normal tissues and 7 polyps were profiled for miR-21 and PDCD4 gene expression; A significant inverse relationship between miR-21 and PDCD4 gene expression p < 0.001 was identified by RT-qPCR; In addition significant reduction of PDCD4 p < 0.001 expression and reciprocal upregulation of miR-21 p = 0.005 in a progressive manner from tumour-polyp-normal mucosae was identified; This study demonstrates the inverse relationship between miR-21 and PDCD4 thus suggesting that miR-21 post-transcriptionally modulates PDCD4 via mRNA degradation;Expression patterns of miR-21 RNA and its target tumor suppressor protein PDCD4 were mutually exclusive;Exosome shuttling microRNA 21 promotes cell migration and invasion targeting PDCD4 in esophageal cancer;Fenhexamid and fludioxonil stimulated miR-21 expression in a concentration-dependent manner and reduced the expression of miR-21 target Pdcd4 protein; Antisense to miR-21 blocked the increase in Pdcd4 protein by fenhexamid and fludioxonil;The expression of programmed cell death 4 PDCD4 which is a miR-21 targeting apoptotic gene has also been enhanced by UA; And over-expression of miR-21 in U251 cells abolished the enhancement of PDCD4 protein by UA;This process leads to microRNA-21 miR-21 production and a tumor suppressor protein e.g PDCD4 program cell death 4 reduction; Transfection of MCF-7 cells with PKCepsilon or Nanog-specific small interfering RNAs effectively blocks HA-mediated PKCepsilon-Nanog signaling events abrogates miR-21 production and increases PDCD4 expression/eIF4A binding;Through dual-luciferase method it was verified that PDCD4 and PDCD10 were real target genes of miR-21 and miR-200c respectively;miR-21 and miR-155 expression was assessed in tumor tissue and in adjacent normal tissue of 156 CRC patients by TaqMan MicroRNA assays and PDCD4 and TP53INP1 mRNA levels were measured by quantitative real-time reverse transcriptase PCR RT-PCR; Significant inverse correlations were demonstrated between miR-21 and PDCD4 mRNA and miR-155 and TP53INP1 mRNA;The aim of this study was a to determine a role of microRNA-21 in esophageal squamous cell carcinoma and b to elucidate the regulation of the programmed cell death 4 PDCD4 gene by microRNA-21; In addition the regulation of PDCD4 by microRNA-21 was elucidated to identify the mechanisms of this regulation; The PDCD4 protein levels in esophageal squamous cell carcinoma cells have an inverse correlation with microRNA-21 expression; MicroRNA-21 targets PDCD4 at the posttranscriptional level and regulates cell proliferation and invasion in esophageal squamous cell carcinoma;Maspin Pdcd4 and miR-21 expressions were evaluated by a real-time polymerase chain reaction in 20 endometrial cancer and 10 normal endometrium samples; Comparison between IA and more advanced International Federation of Gynecology and Obstetrics stages of endometrial cancer in regard to expression levels of maspin Pdcd4 and miR-21 did not reveal any significant differences;MicroRNA 21 induces 5 fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4; The proresistance effects of miR-21 were attributed to the attenuated expression of tumor suppressor genes including PTEN and PDCD4;Sequence prediction and gene expression regulation assays showed that miR-21 could reversely regulate the expression of PDCD4 P < 0.01; Suppression of miR-21 expression is associated with an elevation of Pdcd4 resulting in a significant reduction of proliferation and the apoptosis rate 2.6% was increased to 10.9%; Moreover the anti-proliferation and pro-apoptotic effect by miR-21 suppression could be reversed by PDCD4 knock down;Downregulation of Pdcd4 by mir 21 facilitates glioblastoma proliferation in vivo; We demonstrate that downregulation of mir-21 in glioblastoma-derived cell lines results in increased expression of its target programmed cell death 4 Pdcd4 a known tumor-suppressor gene; In addition our data indicate that either downregulation of mir-21 or overexpression of its target Pdcd4 in glioblastoma-derived cell lines leads to decreased proliferation increased apoptosis and decreased colony formation in soft agar; Using a glioblastoma xenograft model in immune-deficient nude mice we observe that glioblastoma-derived cell lines in which mir-21 levels are downregulated or Pdcd4 is over-expressed exhibit decreased tumor formation and growth; These critical in vivo findings demonstrate an important functional linkage between mir-21 and Pdcd4 and further elucidate the molecular mechanisms by which the known high level of mir-21 expression in glioblastoma can attribute to tumorigenesis--namely inhibition of Pdcd4 and its tumor-suppressive functions ;;staging;metastasis;differentiation;tumorigenesis;;;worse prognosis;;staging;;metastasis;;metastasis;progression;;;;;;poor survival;;;;;metastasis;;metastasis;poor survival;drug resistance;;;;;drug resistance;;;progression;;metastasis;metastasis;staging;;;drug resistance;;;;drug resistance;;;;;metastasis;;differentiation;drug resistance;;;malignant trasformation;malignant trasformation;metastasis;progression;;cell migration;;;;;;;staging;drug resistance;;tumorigenesis gastric cancer;gastric cancer;gastric cancer;gastric cancer;chronic myeloid leukemia;thyroid cancer;colon cancer;colorectal cancer;liver cancer;colon cancer;liver cancer;retinoblastoma;cervical and endocervical cancer;prostate cancer;lung squamous cell cancer;prostate cancer;colorectal cancer;glioblastoma;thyroid cancer;colon cancer;ovarian cancer;ovarian cancer;kidney renal cell cancer;ovarian cancer;colorectal cancer;liver cancer;breast cancer;esophageal cancer;glioblastoma;breast cancer;lung squamous cell cancer;breast cancer;breast cancer;kidney renal cell cancer;glioblastoma;colorectal cancer;colorectal cancer;colorectal cancer;lung cancer;prostate cancer;prostate cancer;B cell lymphoma;glioblastoma;head and neck cancer;glioblastoma;ovarian cancer;liver cancer;colon cancer;breast cancer;breast cancer;B cell lymphoma;acute myeloid leukemia;glioblastoma;prostate cancer;pancreatic cancer;esophageal cancer;melanoma;colorectal cancer;colorectal cancer;esophageal cancer;breast cancer;glioblastoma;breast cancer;breast cancer;colorectal cancer;esophageal cancer;endometrial cancer;pancreatic cancer;lung squamous cell cancer;glioblastoma hsa-miR-200b-3p PDE10A 2.06025765178663 3.07718049337497e-10 0.471395454621627 0.0282321530981893 mirMAP -0.191678076184194 4.93259641402478e-07 NA NA NA hsa-miR-335-3p PDE10A 2.29463721765513 4.1956113745077e-18 0.471395454621627 0.0282321530981893 mirMAP -0.113104594915023 0.0152061833736997 NA NA NA hsa-miR-200a-3p PDE1C 2.02394729844446 2.21240501925011e-08 -1.7653770006995 1.22986150367139e-10 mirMAP -0.400490207872502 3.03333392294342e-20 NA NA NA hsa-miR-21-5p PDE1C 2.21515015440792 6.0468197386674e-49 -1.7653770006995 1.22986150367139e-10 mirMAP -0.8167734449933 1.36780147337487e-19 NA NA NA hsa-miR-335-3p PDE1C 2.29463721765513 4.1956113745077e-18 -1.7653770006995 1.22986150367139e-10 mirMAP -0.513360637435073 4.48044327405312e-19 NA NA NA hsa-miR-192-5p PDE2A 2.0867723747501 3.57854249239079e-08 -1.60248133935421 4.94483694901693e-10 miRNAWalker2_validate -0.342811496465308 2.2104300980193e-18 NA NA NA hsa-miR-183-5p PDE3A 2.08412478942637 1.08931431254487e-10 -0.206426579279772 0.513859856563382 miRNATAP -0.543691949365195 3.83216536250657e-25 NA NA NA hsa-miR-335-3p PDE3A 2.29463721765513 4.1956113745077e-18 -0.206426579279772 0.513859856563382 mirMAP -0.369532049984436 3.1265420222127e-08 NA NA NA hsa-miR-335-3p PDE4B 2.29463721765513 4.1956113745077e-18 -0.199783871794764 0.339806598497732 mirMAP -0.191385603419281 1.84758462810717e-05 NA NA NA hsa-miR-183-5p PDE4D 2.08412478942637 1.08931431254487e-10 -0.501529812759653 0.00928430510499284 miRNATAP -0.284449984358766 9.27475128996122e-18 NA NA NA hsa-miR-18a-5p PDE4D 2.04701000113742 1.30593450319289e-12 -0.501529812759653 0.00928430510499284 miRNAWalker2_validate;miRNATAP -0.279245973365489 8.82836095559533e-14 NA NA NA hsa-miR-200b-3p PDE4D 2.06025765178663 3.07718049337497e-10 -0.501529812759653 0.00928430510499284 mirMAP -0.222531945145119 3.86446779635637e-11 NA NA NA hsa-miR-335-3p PDE4D 2.29463721765513 4.1956113745077e-18 -0.501529812759653 0.00928430510499284 mirMAP -0.275828701616947 7.64106227814493e-12 NA NA NA hsa-miR-200a-5p PDE4DIP 2.19152245759943 3.17968183522514e-11 -0.282404848715995 0.0257038721492497 mirMAP -0.147053537700498 1.20668696725721e-11 NA NA NA hsa-miR-18a-5p PDE5A 2.04701000113742 1.30593450319289e-12 -0.660401490828103 0.00319485531364013 MirTarget -0.402142805195531 1.72650265042172e-21 NA NA NA hsa-miR-335-3p PDE5A 2.29463721765513 4.1956113745077e-18 -0.660401490828103 0.00319485531364013 MirTarget;mirMAP -0.26635740436893 2.20841205124329e-08 NA NA NA hsa-miR-146b-5p PDE7B 2.23105707690238 3.83997814011313e-23 -1.29539183024445 1.64484072041103e-05 miRanda;mirMAP -0.452321904902336 9.98881911370899e-10 NA NA NA hsa-miR-200b-3p PDE7B 2.06025765178663 3.07718049337497e-10 -1.29539183024445 1.64484072041103e-05 TargetScan -0.516831622112932 8.04451430109395e-25 NA NA NA hsa-miR-335-3p PDE7B 2.29463721765513 4.1956113745077e-18 -1.29539183024445 1.64484072041103e-05 mirMAP -0.547416303120923 8.17527886470863e-19 NA NA NA hsa-miR-935 PDE7B 2.321600496365 1.00042201726114e-07 -1.29539183024445 1.64484072041103e-05 PITA;miRNATAP -0.364490113835449 9.83902840906582e-19 NA NA NA hsa-miR-135b-5p PDE8B 2.80066701698235 2.12546333413447e-11 -1.01467231191341 5.51605369397823e-06 MirTarget -0.273122270563358 2.55255711832239e-18 NA NA NA hsa-miR-335-3p PDE8B 2.29463721765513 4.1956113745077e-18 -1.01467231191341 5.51605369397823e-06 mirMAP -0.336779296304044 8.8722274118439e-13 NA NA NA hsa-miR-335-3p PDGFC 2.29463721765513 4.1956113745077e-18 -0.330201277237838 0.0648348934349677 mirMAP -0.184328995783321 1.28616009770146e-06 NA NA NA hsa-miR-21-5p PDGFD 2.21515015440792 6.0468197386674e-49 -1.14874460605402 8.02733598895641e-07 miRNAWalker2_validate -0.377074482110946 2.14599069029555e-06 NA NA NA hsa-miR-335-3p PDGFD 2.29463721765513 4.1956113745077e-18 -1.14874460605402 8.02733598895641e-07 mirMAP -0.317982142128345 1.67198690142818e-10 NA NA NA hsa-miR-146b-5p PDGFRA 2.23105707690238 3.83997814011313e-23 -0.372284813228336 0.00370015308240111 miRanda -0.136098576006454 1.79174981111242e-05 NA NA NA hsa-miR-200a-3p PDGFRA 2.02394729844446 2.21240501925011e-08 -0.372284813228336 0.00370015308240111 MirTarget -0.132237622158925 9.44487536016183e-11 NA NA NA hsa-miR-335-3p PDGFRA 2.29463721765513 4.1956113745077e-18 -0.372284813228336 0.00370015308240111 mirMAP -0.123558608227758 6.79522440678339e-06 NA NA NA hsa-miR-1-3p PDIK1L -2.73171785118192 3.4424534921136e-12 0.364142171701499 0.00121564664360239 MirTarget -0.105427961491397 8.93562969017637e-11 NA NA NA hsa-miR-146b-5p PDK4 2.23105707690238 3.83997814011313e-23 -2.72064215500525 3.77755401072187e-12 miRanda -0.833389678093224 3.16171212635342e-18 NA NA NA hsa-miR-192-5p PDLIM3 2.0867723747501 3.57854249239079e-08 -1.37109689119218 2.54104405288571e-05 miRNAWalker2_validate -0.527976606659045 4.68334924766833e-30 NA NA NA hsa-miR-146b-5p PDZD2 2.23105707690238 3.83997814011313e-23 -0.908543541829336 3.29621056037723e-05 miRanda -0.428147660297541 2.80157486252996e-16 NA NA NA hsa-miR-146b-5p PDZRN3 2.23105707690238 3.83997814011313e-23 -1.54750832250416 3.14930689180064e-07 miRNATAP -0.648765299044215 2.27630900861838e-19 NA NA NA hsa-miR-183-5p PEAK1 2.08412478942637 1.08931431254487e-10 0.498401249194297 3.01095206451051e-05 miRNAWalker2_validate;mirMAP -0.114866410431794 9.93417353006958e-08 NA NA NA hsa-miR-135b-5p PEG10 2.80066701698235 2.12546333413447e-11 -0.923830356589349 0.0635167759202539 mirMAP -0.387258151408801 6.80005322763949e-08 NA NA NA hsa-miR-146b-5p PEG10 2.23105707690238 3.83997814011313e-23 -0.923830356589349 0.0635167759202539 PITA;miRanda -0.682315218345893 2.00035635554682e-08 NA NA NA hsa-miR-200b-3p PEG10 2.06025765178663 3.07718049337497e-10 -0.923830356589349 0.0635167759202539 mirMAP -0.624581712586134 4.05679985141568e-13 NA NA NA hsa-miR-335-3p PEG10 2.29463721765513 4.1956113745077e-18 -0.923830356589349 0.0635167759202539 mirMAP -0.367832230431031 0.000613022096563029 NA NA NA hsa-miR-135b-5p PELI3 2.80066701698235 2.12546333413447e-11 -0.360430860117122 0.0133006560616424 mirMAP -0.114969689107113 4.10075307746227e-08 NA NA NA hsa-miR-21-5p PER2 2.21515015440792 6.0468197386674e-49 -0.395965365387413 0.00269369810613991 MirTarget -0.162504183431927 0.00027962681251565 NA NA NA hsa-miR-194-5p PER3 2.24386881692218 9.35116329002209e-11 -1.21493267564586 1.08869327262652e-08 miRNATAP -0.219688384928105 1.12382925431534e-09 NA NA NA hsa-miR-21-5p PER3 2.21515015440792 6.0468197386674e-49 -1.21493267564586 1.08869327262652e-08 miRNAWalker2_validate -0.49883605660383 2.85436632603892e-12 NA NA NA hsa-miR-335-3p PER3 2.29463721765513 4.1956113745077e-18 -1.21493267564586 1.08869327262652e-08 MirTarget -0.310028315891866 1.00226334414943e-11 NA NA NA hsa-miR-200a-3p PFKM 2.02394729844446 2.21240501925011e-08 -0.230124644491232 0.123858439725693 MirTarget -0.188145451139731 4.87692185427919e-16 NA NA NA hsa-miR-21-5p PFKM 2.21515015440792 6.0468197386674e-49 -0.230124644491232 0.123858439725693 MirTarget -0.164423256062987 0.00114039843948823 NA NA NA hsa-miR-183-5p PFN2 2.08412478942637 1.08931431254487e-10 -0.308124594300883 0.268763972752918 MirTarget;miRNATAP -0.213268295058106 2.16263361073911e-05 NA NA NA hsa-miR-194-5p PFN2 2.24386881692218 9.35116329002209e-11 -0.308124594300883 0.268763972752918 miRNATAP -0.325457995562466 6.97211104397142e-13 NA NA NA hsa-miR-200b-3p PFN2 2.06025765178663 3.07718049337497e-10 -0.308124594300883 0.268763972752918 TargetScan -0.297554388705208 1.03012453965708e-09 NA NA NA hsa-miR-146b-5p PGC 2.23105707690238 3.83997814011313e-23 -3.56462843626573 0.00024093828344602 miRanda -0.672094202724868 0.00604990318459562 NA NA NA hsa-miR-192-5p PGR 2.0867723747501 3.57854249239079e-08 -1.70372832227161 1.59241316109545e-07 mirMAP -0.459069004158088 2.28813593069438e-21 NA NA NA hsa-miR-335-3p PGR 2.29463721765513 4.1956113745077e-18 -1.70372832227161 1.59241316109545e-07 mirMAP -0.586445622799593 3.97867888106832e-18 NA NA NA hsa-miR-21-5p PGRMC2 2.21515015440792 6.0468197386674e-49 -0.829994806645235 1.26502386117404e-18 miRNAWalker2_validate -0.22005475567961 2.34469526046833e-11 NA NA NA hsa-miR-183-5p PHACTR1 2.08412478942637 1.08931431254487e-10 -0.365364022078134 0.110182412221714 mirMAP -0.306022390326285 1.27038379800482e-14 NA NA NA hsa-miR-200b-3p PHACTR3 2.06025765178663 3.07718049337497e-10 -0.760898446997406 0.0651038398581359 MirTarget;TargetScan -0.194945329476753 0.00883060443619837 NA NA NA hsa-miR-141-5p PHC3 2.13747696823946 1.73124674554872e-11 0.211887804282655 0.0498991979774048 MirTarget -0.113034113189541 5.49564631077121e-09 NA NA NA hsa-miR-18a-5p PHC3 2.04701000113742 1.30593450319289e-12 0.211887804282655 0.0498991979774048 MirTarget -0.108893134261913 3.73340524109597e-07 NA NA NA hsa-miR-146b-5p PHF1 2.23105707690238 3.83997814011313e-23 -0.682869794290047 3.35916503110129e-09 miRanda;miRNATAP -0.209006361419218 1.50486649517982e-13 NA NA NA hsa-miR-194-5p PHF1 2.24386881692218 9.35116329002209e-11 -0.682869794290047 3.35916503110129e-09 miRNATAP -0.166149480622753 1.23213940917462e-18 NA NA NA hsa-miR-192-5p PHF10 2.0867723747501 3.57854249239079e-08 -0.118034981153644 0.293969343023263 miRNAWalker2_validate -0.121691340769862 4.56039736187872e-13 NA NA NA hsa-miR-146b-5p PHF2 2.23105707690238 3.83997814011313e-23 -0.150674147918518 0.0985449275692071 miRanda -0.139989519064353 1.57641411029063e-10 NA NA NA hsa-miR-18a-5p PHF2 2.04701000113742 1.30593450319289e-12 -0.150674147918518 0.0985449275692071 MirTarget;miRNATAP -0.120911537102356 7.8302667724865e-12 NA NA NA hsa-miR-192-5p PHF21A 2.0867723747501 3.57854249239079e-08 -0.314340471617779 0.00621059979506441 mirMAP -0.187949400814475 7.85348360796052e-32 NA NA NA hsa-miR-200b-3p PHF21A 2.06025765178663 3.07718049337497e-10 -0.314340471617779 0.00621059979506441 MirTarget;TargetScan -0.206900602949406 1.06629659174374e-28 NA NA NA hsa-miR-200b-3p PHF21B 2.06025765178663 3.07718049337497e-10 -1.94296466828798 2.59177331886843e-05 MirTarget;TargetScan -0.706650141469302 3.52466567318501e-19 NA NA NA hsa-miR-1-3p PHF6 -2.73171785118192 3.4424534921136e-12 0.785239232720584 1.42133456657009e-09 MirTarget -0.145723146612877 1.38095995966009e-14 NA NA NA hsa-miR-194-5p PHLDA1 2.24386881692218 9.35116329002209e-11 0.0567884450533462 0.781587932313117 MirTarget -0.120052042865084 0.000503577719213008 NA NA NA hsa-miR-200b-3p PHLDB1 2.06025765178663 3.07718049337497e-10 0.238938319482238 0.132122406244892 MirTarget;TargetScan -0.242654371116382 7.10759493249702e-20 NA NA NA hsa-miR-135b-5p PHLDB2 2.80066701698235 2.12546333413447e-11 -0.643125760304128 0.012847520867423 MirTarget -0.300397760720442 6.50125182973668e-17 NA NA NA hsa-miR-183-5p PHLDB2 2.08412478942637 1.08931431254487e-10 -0.643125760304128 0.012847520867423 MirTarget -0.463939693761233 1.81310633872853e-27 NA NA NA hsa-miR-335-3p PHLDB2 2.29463721765513 4.1956113745077e-18 -0.643125760304128 0.012847520867423 mirMAP -0.380518905354173 1.66101046027364e-12 NA NA NA hsa-miR-146b-5p PHOX2B 2.23105707690238 3.83997814011313e-23 -2.68021835531067 3.44146467075843e-07 miRNATAP -1.00385049284054 3.44875513520223e-15 NA NA NA hsa-miR-935 PHOX2B 2.321600496365 1.00042201726114e-07 -2.68021835531067 3.44146467075843e-07 mirMAP -0.46335202134395 8.00913864776811e-10 NA NA NA hsa-miR-192-5p PHTF2 2.0867723747501 3.57854249239079e-08 0.581604321532215 2.7972387423281e-07 miRNAWalker2_validate -0.109363781022406 4.68953128914201e-10 NA NA NA hsa-miR-146b-5p PHYHIPL 2.23105707690238 3.83997814011313e-23 -0.966544312992314 0.00165283097242769 miRanda -0.350843306402786 4.1024672740694e-06 NA NA NA hsa-miR-200a-3p PHYHIPL 2.02394729844446 2.21240501925011e-08 -0.966544312992314 0.00165283097242769 MirTarget;miRNATAP -0.357451205328329 1.91815403829628e-13 NA NA NA hsa-miR-335-3p PHYHIPL 2.29463721765513 4.1956113745077e-18 -0.966544312992314 0.00165283097242769 MirTarget -0.202711481943674 0.00240163669778134 NA NA NA hsa-miR-146b-5p PID1 2.23105707690238 3.83997814011313e-23 -1.58515404529655 7.01847972866481e-08 miRanda -0.511341014935286 1.47552304636663e-12 NA NA NA hsa-miR-335-3p PID1 2.29463721765513 4.1956113745077e-18 -1.58515404529655 7.01847972866481e-08 mirMAP -0.336726354782674 1.39963508697766e-07 NA NA NA hsa-miR-335-3p PIK3CG 2.29463721765513 4.1956113745077e-18 -0.431523776023951 0.105004494916123 mirMAP -0.236740995358545 3.30421401118699e-05 NA NA NA hsa-miR-200b-3p PIK3R1 2.06025765178663 3.07718049337497e-10 -0.132584613334835 0.368540743016032 mirMAP -0.190323937293919 4.94804536331339e-14 NA NA NA hsa-miR-21-5p PIK3R1 2.21515015440792 6.0468197386674e-49 -0.132584613334835 0.368540743016032 miRNAWalker2_validate;MirTarget;miRNATAP -0.149170797978773 0.00275496702870304 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-133a-3p PIK3R2 -2.63342156915404 5.72661351480585e-12 0.6802233434179 1.14371526174319e-06 miRNAWalker2_validate -0.113207314566063 1.18348525180172e-07 NA NA NA hsa-miR-146b-3p PIM1 2.08650140817622 5.3293570720033e-22 -1.11369789456653 7.42912371797285e-11 PITA;miRNATAP -0.112609068533268 0.0150414984239924 NA NA NA hsa-miR-183-5p PIM1 2.08412478942637 1.08931431254487e-10 -1.11369789456653 7.42912371797285e-11 miRNATAP -0.130198547300992 4.80830270544081e-05 NA NA NA hsa-miR-192-5p PIM1 2.0867723747501 3.57854249239079e-08 -1.11369789456653 7.42912371797285e-11 miRNAWalker2_validate -0.125812320360565 4.57886158777155e-06 NA NA NA hsa-miR-146b-5p PIN1 2.23105707690238 3.83997814011313e-23 -0.601595845718044 6.16833393153367e-10 miRanda -0.130934815481738 8.3350177252387e-08 NA NA NA hsa-miR-194-5p PIP4K2A 2.24386881692218 9.35116329002209e-11 0.0497046247727253 0.656960215436939 MirTarget -0.109119718436651 2.89733555382082e-09 NA NA NA hsa-miR-200b-3p PIP4K2A 2.06025765178663 3.07718049337497e-10 0.0497046247727253 0.656960215436939 TargetScan -0.145799976846135 2.22527893941728e-14 NA NA NA hsa-miR-335-3p PIP4K2A 2.29463721765513 4.1956113745077e-18 0.0497046247727253 0.656960215436939 mirMAP -0.113285165329247 1.72146642760098e-06 NA NA NA hsa-miR-192-5p PIP4K2B 2.0867723747501 3.57854249239079e-08 0.176396912458267 0.06975976166235 miRNAWalker2_validate -0.103001064146051 1.58975324185675e-12 NA NA NA hsa-miR-200b-3p PIP4K2B 2.06025765178663 3.07718049337497e-10 0.176396912458267 0.06975976166235 TargetScan -0.13402459650587 4.4534617959894e-16 NA NA NA hsa-miR-92a-1-5p PIP5K1C 2.04820501765632 9.32117486799495e-13 -0.340857900375792 0.0062974753752012 MirTarget -0.151748093137986 1.83455501979994e-09 NA NA NA hsa-miR-192-5p PITPNB 2.0867723747501 3.57854249239079e-08 0.0720431781897597 0.527037368114435 miRNAWalker2_validate -0.105520231928809 9.62989185997897e-10 NA NA NA hsa-miR-183-5p PITPNM2 2.08412478942637 1.08931431254487e-10 -0.467517560436463 0.00215939954517204 mirMAP -0.21818122439277 1.2645736520421e-16 NA NA NA hsa-miR-18a-5p PITPNM2 2.04701000113742 1.30593450319289e-12 -0.467517560436463 0.00215939954517204 mirMAP -0.18681392085075 5.54018576994331e-10 NA NA NA hsa-miR-194-5p PITPNM2 2.24386881692218 9.35116329002209e-11 -0.467517560436463 0.00215939954517204 MirTarget;miRNATAP -0.213722577847044 1.75360507742503e-18 NA NA NA hsa-miR-935 PITPNM2 2.321600496365 1.00042201726114e-07 -0.467517560436463 0.00215939954517204 PITA;miRNATAP -0.102052227038213 2.79843303881255e-06 NA NA NA hsa-miR-200a-5p PITPNM3 2.19152245759943 3.17968183522514e-11 -1.63914377631659 3.3142339868577e-07 MirTarget -0.394246037510243 2.20198046629736e-12 NA NA NA hsa-miR-200b-3p PITPNM3 2.06025765178663 3.07718049337497e-10 -1.63914377631659 3.3142339868577e-07 MirTarget;TargetScan -0.39642604073762 3.28390154622178e-12 NA NA NA hsa-miR-200a-3p PITX2 2.02394729844446 2.21240501925011e-08 0.203565332895925 0.726367722949401 miRNATAP -0.342158792256051 0.000307048956793524 NA NA NA hsa-miR-21-5p PITX2 2.21515015440792 6.0468197386674e-49 0.203565332895925 0.726367722949401 miRNATAP -0.50589515110708 0.0104200325169408 NA NA NA hsa-miR-194-5p PJA2 2.24386881692218 9.35116329002209e-11 -0.719883225002786 4.46881370628398e-08 MirTarget -0.205975734472452 1.38534308645682e-22 NA NA NA hsa-miR-21-5p PJA2 2.21515015440792 6.0468197386674e-49 -0.719883225002786 4.46881370628398e-08 MirTarget -0.313158093893465 9.89815891158707e-13 NA NA NA hsa-miR-200b-3p PKD1 2.06025765178663 3.07718049337497e-10 -0.179389262603771 0.299404915965228 TargetScan -0.294552888291482 2.33820900238004e-25 NA NA NA hsa-miR-183-5p PKD2 2.08412478942637 1.08931431254487e-10 -0.239902831398395 0.217409599623742 MirTarget;miRNATAP -0.390790273281262 7.1710256748922e-37 NA NA NA hsa-miR-194-5p PKD2 2.24386881692218 9.35116329002209e-11 -0.239902831398395 0.217409599623742 miRNATAP -0.302296587025123 1.74025850634661e-23 NA NA NA hsa-miR-21-5p PKD2 2.21515015440792 6.0468197386674e-49 -0.239902831398395 0.217409599623742 miRNAWalker2_validate -0.284314803867733 1.31368399072314e-05 NA NA NA hsa-miR-146b-5p PKD2L2 2.23105707690238 3.83997814011313e-23 -0.253451472790175 0.0780871216669883 miRanda -0.114488780866061 0.00134655002444803 NA NA NA hsa-miR-135b-5p PKHD1L1 2.80066701698235 2.12546333413447e-11 -2.65381993068564 2.16260638001553e-12 MirTarget -0.474893687300663 2.61143083538647e-18 NA NA NA hsa-miR-200a-3p PKIA 2.02394729844446 2.21240501925011e-08 -1.26431427605 5.26373640576521e-06 mirMAP -0.421823783409758 4.4935426459343e-23 NA NA NA hsa-miR-200b-3p PKIA 2.06025765178663 3.07718049337497e-10 -1.26431427605 5.26373640576521e-06 MirTarget;TargetScan -0.456484235724047 2.4040542639679e-22 NA NA NA hsa-miR-335-3p PKIA 2.29463721765513 4.1956113745077e-18 -1.26431427605 5.26373640576521e-06 mirMAP -0.41120493576963 2.53821653455901e-12 NA NA NA hsa-miR-935 PKIA 2.321600496365 1.00042201726114e-07 -1.26431427605 5.26373640576521e-06 miRNATAP -0.320967580203774 6.96511851465903e-17 NA NA NA hsa-miR-935 PKIB 2.321600496365 1.00042201726114e-07 -1.36447607789781 2.30392564839379e-05 PITA -0.125500280194066 0.00784257187642222 NA NA NA hsa-miR-183-5p PKNOX2 2.08412478942637 1.08931431254487e-10 -2.03108855307726 2.58356514169281e-10 miRNATAP -0.639947054982016 8.93341342045379e-33 NA NA NA hsa-miR-192-5p PKP1 2.0867723747501 3.57854249239079e-08 0.209675697804554 0.734979291630452 mirMAP -0.369953844871636 0.000122969619879608 NA NA NA hsa-miR-146b-3p PLA2G4C 2.08650140817622 5.3293570720033e-22 -0.482457679312224 0.0467763043515252 miRNATAP -0.213491198104409 0.000720739165921793 NA NA NA hsa-miR-146b-5p PLAGL1 2.23105707690238 3.83997814011313e-23 -0.587922799208326 0.00911996883546906 miRanda -0.284691247381693 2.81867588724072e-07 NA NA NA hsa-miR-21-5p PLAT 2.21515015440792 6.0468197386674e-49 -0.559228051840959 0.00104135060013876 miRNAWalker2_validate;miRTarBase -0.187692286863916 0.00124635653842505 19308091 We also demonstrated that both deltaEF1 and TPA induced miR-21 expression breast cancer hsa-miR-335-3p PLCB1 2.29463721765513 4.1956113745077e-18 0.123551158612559 0.611417553109125 mirMAP -0.155081868023876 0.00307347986853507 NA NA NA hsa-miR-183-5p PLCB4 2.08412478942637 1.08931431254487e-10 -0.289150265259597 0.333879464094846 miRNATAP -0.131734964788475 0.0157253349372858 NA NA NA hsa-miR-146b-3p PLCD1 2.08650140817622 5.3293570720033e-22 -1.13564485883749 1.78619079861029e-13 miRNATAP -0.275451716366011 1.22647363827712e-11 NA NA NA hsa-miR-146b-5p PLCL1 2.23105707690238 3.83997814011313e-23 -0.868784420124132 0.000104162683697075 miRanda -0.323235549553951 4.33318686777721e-09 NA NA NA hsa-miR-200a-3p PLCL1 2.02394729844446 2.21240501925011e-08 -0.868784420124132 0.000104162683697075 MirTarget -0.387969816647607 6.22812840845898e-32 NA NA NA hsa-miR-200b-3p PLCL1 2.06025765178663 3.07718049337497e-10 -0.868784420124132 0.000104162683697075 MirTarget;TargetScan -0.421479899586077 4.06733605756339e-31 NA NA NA hsa-miR-335-3p PLCL1 2.29463721765513 4.1956113745077e-18 -0.868784420124132 0.000104162683697075 MirTarget -0.431994629291612 1.57083543313051e-21 NA NA NA hsa-miR-183-5p PLCXD3 2.08412478942637 1.08931431254487e-10 -3.47820333039959 1.97747441352297e-11 miRNATAP -0.836033712877981 7.97343438909032e-20 NA NA NA hsa-miR-200a-3p PLCXD3 2.02394729844446 2.21240501925011e-08 -3.47820333039959 1.97747441352297e-11 miRNATAP -0.6155657414053 4.21874430731253e-13 NA NA NA hsa-miR-200a-5p PLCXD3 2.19152245759943 3.17968183522514e-11 -3.47820333039959 1.97747441352297e-11 mirMAP -0.694677179845438 3.4023077959466e-14 NA NA NA hsa-miR-200b-3p PLCXD3 2.06025765178663 3.07718049337497e-10 -3.47820333039959 1.97747441352297e-11 TargetScan -0.671794173420585 5.94998609586976e-13 NA NA NA hsa-miR-335-3p PLCXD3 2.29463721765513 4.1956113745077e-18 -3.47820333039959 1.97747441352297e-11 mirMAP -0.784720026972615 2.76985869032372e-12 NA NA NA hsa-miR-935 PLCXD3 2.321600496365 1.00042201726114e-07 -3.47820333039959 1.97747441352297e-11 miRNATAP -0.618587281404153 3.54103761052753e-17 NA NA NA hsa-miR-335-3p PLEKHA2 2.29463721765513 4.1956113745077e-18 -0.0668980138715556 0.616274845242596 mirMAP -0.114956171420698 5.40329433071941e-05 NA NA NA hsa-miR-146b-5p PLEKHA5 2.23105707690238 3.83997814011313e-23 -0.0209985094569882 0.878336125773638 miRanda -0.132270450192259 9.02297404763813e-05 NA NA NA hsa-miR-183-5p PLEKHA5 2.08412478942637 1.08931431254487e-10 -0.0209985094569882 0.878336125773638 MirTarget -0.140087040481229 7.85565164092996e-09 NA NA NA hsa-miR-192-5p PLEKHG2 2.0867723747501 3.57854249239079e-08 0.649639224953562 1.47814580043559e-05 miRNAWalker2_validate -0.105850536903389 6.94688839027781e-06 NA NA NA hsa-miR-146b-5p PLEKHG4B 2.23105707690238 3.83997814011313e-23 -1.4425803087495 0.000248351299337546 mirMAP -0.460224455468545 2.58692583301127e-06 NA NA NA hsa-miR-92a-1-5p PLEKHG4B 2.04820501765632 9.32117486799495e-13 -1.4425803087495 0.000248351299337546 mirMAP -0.269050027743415 0.00108995778216691 NA NA NA hsa-miR-146b-5p PLEKHH2 2.23105707690238 3.83997814011313e-23 -0.174010546464577 0.514498068561791 miRanda;miRNATAP -0.26667577677289 5.17505838296632e-05 NA NA NA hsa-miR-935 PLEKHH2 2.321600496365 1.00042201726114e-07 -0.174010546464577 0.514498068561791 MirTarget;PITA;miRNATAP -0.19276794109246 3.30702723843587e-07 NA NA NA hsa-miR-146b-3p PLEKHH3 2.08650140817622 5.3293570720033e-22 -0.679485553339659 2.25298488473907e-09 PITA;miRNATAP -0.134491421226442 7.87665320285159e-06 NA NA NA hsa-miR-146b-5p PLEKHM3 2.23105707690238 3.83997814011313e-23 -0.264766226099178 0.0391508799138563 MirTarget;miRanda -0.206822589287968 2.04797297256992e-11 NA NA NA hsa-miR-183-5p PLEKHM3 2.08412478942637 1.08931431254487e-10 -0.264766226099178 0.0391508799138563 MirTarget -0.194695100374539 5.03258938350965e-19 NA NA NA hsa-miR-200b-3p PLEKHM3 2.06025765178663 3.07718049337497e-10 -0.264766226099178 0.0391508799138563 MirTarget;TargetScan -0.184162958317684 2.46449741384261e-17 NA NA NA hsa-miR-335-3p PLEKHM3 2.29463721765513 4.1956113745077e-18 -0.264766226099178 0.0391508799138563 MirTarget -0.131584210840271 1.43043150653175e-06 NA NA NA hsa-miR-935 PLEKHM3 2.321600496365 1.00042201726114e-07 -0.264766226099178 0.0391508799138563 MirTarget -0.103306442893621 1.04328532405362e-08 NA NA NA hsa-miR-135b-5p PLEKHO2 2.80066701698235 2.12546333413447e-11 0.0394623689239282 0.787463161166706 mirMAP -0.123170601175314 3.49717422660741e-09 NA NA NA hsa-miR-335-3p PLIN1 2.29463721765513 4.1956113745077e-18 -2.36224359419327 1.29145387981055e-07 mirMAP -0.207292440441232 0.0370372581435508 NA NA NA hsa-miR-146b-5p PLIN2 2.23105707690238 3.83997814011313e-23 -0.600741160931804 0.00303129387785183 miRanda -0.103038606403102 0.0431943528456142 NA NA NA hsa-miR-196a-5p PLN 5.05945965885472 4.48343841468539e-25 -2.50827119592 3.43657427099495e-08 MirTarget -0.423004363425613 7.95238528827788e-17 NA NA NA hsa-miR-196b-5p PLN 4.51951031652328 7.04026169031626e-18 -2.50827119592 3.43657427099495e-08 MirTarget -0.436307751510944 2.40569934260422e-20 NA NA NA hsa-miR-335-3p PLN 2.29463721765513 4.1956113745077e-18 -2.50827119592 3.43657427099495e-08 mirMAP -0.890785114275195 1.57451404765858e-21 NA NA NA hsa-miR-183-5p PLOD2 2.08412478942637 1.08931431254487e-10 0.0206859895158393 0.906042216365495 miRNAWalker2_validate -0.148227505860964 2.31234111399076e-06 NA NA NA hsa-miR-146b-5p PLP1 2.23105707690238 3.83997814011313e-23 -4.64836727493128 3.84532490629083e-15 miRanda;miRNATAP -1.10163950169912 1.56056157394978e-13 NA NA NA hsa-miR-335-3p PLP1 2.29463721765513 4.1956113745077e-18 -4.64836727493128 3.84532490629083e-15 mirMAP -1.12602451577433 5.44055209455553e-19 NA NA NA hsa-miR-192-5p PLS3 2.0867723747501 3.57854249239079e-08 0.302710860036512 0.0214867475151982 miRNAWalker2_validate -0.115329241982359 1.04819291008112e-08 NA NA NA hsa-miR-146b-5p PLSCR4 2.23105707690238 3.83997814011313e-23 -0.474237245058613 0.0383317279289207 MirTarget;miRanda -0.281442783593564 5.59380789424894e-07 NA NA NA hsa-miR-146b-3p PLXNA2 2.08650140817622 5.3293570720033e-22 -0.394952139559956 0.00778505791950615 MirTarget -0.140826426018731 0.000262147267443248 NA NA NA hsa-miR-146b-5p PLXNA2 2.23105707690238 3.83997814011313e-23 -0.394952139559956 0.00778505791950615 mirMAP -0.178787275396323 9.77484177189764e-07 NA NA NA hsa-miR-183-5p PLXNA4 2.08412478942637 1.08931431254487e-10 0.21299044346966 0.551620295758605 miRNATAP -0.488608296231266 2.77790081065486e-15 NA NA NA hsa-miR-200a-3p PLXNA4 2.02394729844446 2.21240501925011e-08 0.21299044346966 0.551620295758605 mirMAP;miRNATAP -0.468198139391661 2.22095631914119e-17 NA NA NA hsa-miR-200b-3p PLXNA4 2.06025765178663 3.07718049337497e-10 0.21299044346966 0.551620295758605 TargetScan -0.474537186664197 9.46990842562096e-15 NA NA NA hsa-miR-335-3p PLXNA4 2.29463721765513 4.1956113745077e-18 0.21299044346966 0.551620295758605 mirMAP -0.281289887329046 0.000249107052154385 NA NA NA hsa-miR-200a-3p PMP2 2.02394729844446 2.21240501925011e-08 -3.58172675758482 1.88286205374656e-12 MirTarget -0.841033376871552 2.50025820422441e-26 NA NA NA hsa-miR-146b-5p PNMA1 2.23105707690238 3.83997814011313e-23 -0.457408390928892 0.00455224480476945 miRanda -0.22826948405541 6.69754140525969e-09 NA NA NA hsa-miR-135b-5p PNMA3 2.80066701698235 2.12546333413447e-11 -0.375548166950384 0.393396740621177 mirMAP -0.165505486133732 0.0104253046048203 NA NA NA hsa-miR-200a-3p PNMA3 2.02394729844446 2.21240501925011e-08 -0.375548166950384 0.393396740621177 MirTarget -0.184590363162779 0.0105522788439833 NA NA NA hsa-miR-146b-5p PNMAL1 2.23105707690238 3.83997814011313e-23 -0.658807293922857 0.0654165401875963 miRanda -0.368242131237693 3.14519097241532e-05 NA NA NA hsa-miR-183-5p PNOC 2.08412478942637 1.08931431254487e-10 -2.38090270241612 2.98165266904276e-09 miRNATAP -0.431741251368109 4.36891891622201e-09 NA NA NA hsa-miR-1-3p PNP -2.73171785118192 3.4424534921136e-12 -0.185915552567808 0.260223330520435 miRTarBase -0.104453261173907 1.64536547088838e-05 22378464 PTMA and PNP were identified as new target genes regulated by the miR-1 and miR-133a cluster in BC bladder cancer hsa-miR-1-3p POLA1 -2.73171785118192 3.4424534921136e-12 0.745121127719611 1.80487933996452e-10 MirTarget -0.13077097685966 2.13329056465907e-14 NA NA NA hsa-miR-200b-3p POLK 2.06025765178663 3.07718049337497e-10 -0.188751167312746 0.0924696692852844 MirTarget;TargetScan -0.102560157916386 2.07419670429958e-07 NA NA NA hsa-miR-335-3p POLK 2.29463721765513 4.1956113745077e-18 -0.188751167312746 0.0924696692852844 mirMAP -0.133807527653484 1.41452769815642e-08 NA NA NA hsa-miR-192-5p POU2F2 2.0867723747501 3.57854249239079e-08 -0.233199574112698 0.322136968241836 mirMAP -0.14967590648931 4.22770466196341e-05 NA NA NA hsa-miR-141-5p POU3F3 2.13747696823946 1.73124674554872e-11 -0.948560075868461 0.0814987580311117 mirMAP -0.452827767123334 5.22132014470908e-06 NA NA NA hsa-miR-146b-5p POU6F1 2.23105707690238 3.83997814011313e-23 -0.860006522186688 1.36739727981555e-05 mirMAP -0.328542463177415 9.84393109113609e-12 NA NA NA hsa-miR-200b-3p POU6F1 2.06025765178663 3.07718049337497e-10 -0.860006522186688 1.36739727981555e-05 TargetScan -0.416532307174815 2.42244104276495e-41 NA NA NA hsa-miR-146b-3p PPARA 2.08650140817622 5.3293570720033e-22 -0.378523693756559 0.00547606509752035 mirMAP -0.139810023478716 7.65397177680652e-05 NA NA NA hsa-miR-146b-5p PPARA 2.23105707690238 3.83997814011313e-23 -0.378523693756559 0.00547606509752035 mirMAP -0.132516964728803 8.84770600579849e-05 NA NA NA hsa-miR-21-5p PPARA 2.21515015440792 6.0468197386674e-49 -0.378523693756559 0.00547606509752035 miRNAWalker2_validate;miRTarBase;miRNATAP -0.152463272992749 0.000977751305593663 22244963 In the final integrative analysis of lung cancer related miR-21-targets analysis 24 hub genes were identified by overlap calculation suggesting that miR-21 may play an important role in the development and progression of lung cancer through JAK/STAT signal pathway MAPK signaling pathway Wnt signaling pathway cell cycle PPAR signaling pathway apoptosis pathway and other pathways progression lung cancer hsa-miR-92a-1-5p PPARA 2.04820501765632 9.32117486799495e-13 -0.378523693756559 0.00547606509752035 mirMAP -0.100837768791535 0.000350452354669367 NA NA NA hsa-miR-200a-3p PPARGC1A 2.02394729844446 2.21240501925011e-08 -0.787910137017887 0.0327189566676843 mirMAP -0.131946713769855 0.0301080451437747 NA NA NA hsa-miR-335-3p PPARGC1A 2.29463721765513 4.1956113745077e-18 -0.787910137017887 0.0327189566676843 MirTarget;mirMAP -0.27264879301588 0.000617730739333808 NA NA NA hsa-miR-135b-5p PPARGC1B 2.80066701698235 2.12546333413447e-11 -0.801639508723845 5.05451863925204e-05 MirTarget -0.119515446039856 4.1315485331511e-05 NA NA NA hsa-miR-146b-3p PPARGC1B 2.08650140817622 5.3293570720033e-22 -0.801639508723845 5.05451863925204e-05 mirMAP -0.122493796094153 0.0192485997195662 NA NA NA hsa-miR-335-3p PPARGC1B 2.29463721765513 4.1956113745077e-18 -0.801639508723845 5.05451863925204e-05 mirMAP -0.11853856502391 0.00617292910057251 NA NA NA hsa-miR-92a-1-5p PPFIA4 2.04820501765632 9.32117486799495e-13 0.326271949308315 0.301790799101442 MirTarget -0.218515927420938 0.000817739572961399 NA NA NA hsa-miR-194-5p PPFIBP1 2.24386881692218 9.35116329002209e-11 0.0806674750313388 0.54797471582341 MirTarget -0.120693857415491 5.49666290571661e-08 NA NA NA hsa-miR-200a-3p PPFIBP1 2.02394729844446 2.21240501925011e-08 0.0806674750313388 0.54797471582341 MirTarget -0.105447371867627 1.03139014415964e-06 NA NA NA hsa-miR-200b-3p PPFIBP1 2.06025765178663 3.07718049337497e-10 0.0806674750313388 0.54797471582341 TargetScan -0.10400011306473 1.24350553825532e-05 NA NA NA hsa-miR-146b-5p PPIE 2.23105707690238 3.83997814011313e-23 -0.274293808354854 0.00223952695090993 miRanda -0.117052521151435 9.18148863365513e-08 NA NA NA hsa-miR-146b-5p PPIL6 2.23105707690238 3.83997814011313e-23 -0.322016070630686 0.00484184749588703 miRanda -0.110906709392042 8.95599813254924e-05 NA NA NA hsa-miR-92a-1-5p PPL 2.04820501765632 9.32117486799495e-13 -0.714559147658576 0.024215440528081 MirTarget -0.212391190119372 0.00125074047561107 NA NA NA hsa-miR-146b-3p PPM1A 2.08650140817622 5.3293570720033e-22 -0.623302585337666 5.30525296218818e-12 miRNATAP -0.199802429454095 2.70884538371375e-18 NA NA NA hsa-miR-146b-5p PPM1A 2.23105707690238 3.83997814011313e-23 -0.623302585337666 5.30525296218818e-12 miRanda;miRNATAP -0.171890514314492 1.04019076354142e-14 NA NA NA hsa-miR-192-5p PPM1A 2.0867723747501 3.57854249239079e-08 -0.623302585337666 5.30525296218818e-12 miRNAWalker2_validate -0.10289857860824 2.4759358529833e-13 NA NA NA hsa-miR-200a-3p PPM1A 2.02394729844446 2.21240501925011e-08 -0.623302585337666 5.30525296218818e-12 miRNATAP -0.107744877015433 2.3461806765715e-13 NA NA NA hsa-miR-200b-3p PPM1A 2.06025765178663 3.07718049337497e-10 -0.623302585337666 5.30525296218818e-12 mirMAP -0.11602609072098 7.32399639005629e-13 NA NA NA hsa-miR-335-3p PPM1A 2.29463721765513 4.1956113745077e-18 -0.623302585337666 5.30525296218818e-12 mirMAP -0.116776604590373 3.13416290131879e-09 NA NA NA hsa-miR-200a-3p PPM1E 2.02394729844446 2.21240501925011e-08 0.150874141379553 0.574319966175631 MirTarget;miRNATAP -0.180074416894176 3.59986869704649e-05 NA NA NA hsa-miR-200a-5p PPM1E 2.19152245759943 3.17968183522514e-11 0.150874141379553 0.574319966175631 MirTarget -0.197091158249674 2.99259710652706e-05 NA NA NA hsa-miR-200b-3p PPM1E 2.06025765178663 3.07718049337497e-10 0.150874141379553 0.574319966175631 MirTarget -0.202240489972196 2.33199863488032e-05 NA NA NA hsa-miR-183-5p PPM1F 2.08412478942637 1.08931431254487e-10 -0.0631875406709161 0.564184144281478 mirMAP -0.138168114541826 3.5988224302573e-13 NA NA NA hsa-miR-18a-5p PPM1F 2.04701000113742 1.30593450319289e-12 -0.0631875406709161 0.564184144281478 mirMAP -0.13327594414143 4.71631926951734e-10 NA NA NA hsa-miR-200b-3p PPM1F 2.06025765178663 3.07718049337497e-10 -0.0631875406709161 0.564184144281478 MirTarget;TargetScan -0.171024566761045 5.24017186546818e-21 NA NA NA hsa-miR-146b-5p PPM1K 2.23105707690238 3.83997814011313e-23 -0.999161564755304 1.37921237142718e-08 MirTarget;miRanda -0.172010158051188 0.00012215709214682 NA NA NA hsa-miR-200a-3p PPM1K 2.02394729844446 2.21240501925011e-08 -0.999161564755304 1.37921237142718e-08 MirTarget -0.254371836760206 3.19378164127227e-20 NA NA NA hsa-miR-146b-5p PPM1L 2.23105707690238 3.83997814011313e-23 -0.537351176754866 0.00615520293012723 miRanda -0.314881529442139 3.23675880398058e-11 NA NA NA hsa-miR-200a-3p PPM1L 2.02394729844446 2.21240501925011e-08 -0.537351176754866 0.00615520293012723 MirTarget -0.159059387906764 5.57696553757398e-07 NA NA NA hsa-miR-21-5p PPM1L 2.21515015440792 6.0468197386674e-49 -0.537351176754866 0.00615520293012723 miRNAWalker2_validate -0.338741437320256 2.52918687319341e-07 NA NA NA hsa-miR-18a-5p PPP1CB 2.04701000113742 1.30593450319289e-12 -0.697343226432961 3.54901349210579e-12 miRNAWalker2_validate -0.145681749590503 5.79254854572247e-13 NA NA NA hsa-miR-192-5p PPP1CB 2.0867723747501 3.57854249239079e-08 -0.697343226432961 3.54901349210579e-12 miRNAWalker2_validate -0.16403578286484 4.53367132936433e-29 NA NA NA hsa-miR-200b-3p PPP1CB 2.06025765178663 3.07718049337497e-10 -0.697343226432961 3.54901349210579e-12 TargetScan -0.150717204905338 1.28057849740968e-17 NA NA NA hsa-miR-146b-5p PPP1R12A 2.23105707690238 3.83997814011313e-23 -0.344541774510097 0.0204267785092073 miRanda -0.153684945338665 2.86159906072534e-05 NA NA NA hsa-miR-183-5p PPP1R12A 2.08412478942637 1.08931431254487e-10 -0.344541774510097 0.0204267785092073 miRNATAP -0.277302640984552 2.20560992113693e-30 NA NA NA hsa-miR-192-5p PPP1R12A 2.0867723747501 3.57854249239079e-08 -0.344541774510097 0.0204267785092073 miRNAWalker2_validate -0.229511733680736 1.19582084325733e-27 NA NA NA hsa-miR-183-5p PPP1R12B 2.08412478942637 1.08931431254487e-10 -1.13914697277207 0.00076065186660822 mirMAP -0.723782170128185 1.82474183517759e-42 NA NA NA hsa-miR-194-5p PPP1R12B 2.24386881692218 9.35116329002209e-11 -1.13914697277207 0.00076065186660822 mirMAP -0.443615116661435 6.40756124659496e-16 NA NA NA hsa-miR-196a-5p PPP1R12B 5.05945965885472 4.48343841468539e-25 -1.13914697277207 0.00076065186660822 miRNATAP -0.256406586520826 1.3731603226704e-11 NA NA NA hsa-miR-196b-5p PPP1R12B 4.51951031652328 7.04026169031626e-18 -1.13914697277207 0.00076065186660822 miRNATAP -0.267951088354908 3.75028177672392e-14 NA NA NA hsa-miR-200b-3p PPP1R12B 2.06025765178663 3.07718049337497e-10 -1.13914697277207 0.00076065186660822 TargetScan -0.61032224475182 3.15745635337338e-28 NA NA NA hsa-miR-335-3p PPP1R12B 2.29463721765513 4.1956113745077e-18 -1.13914697277207 0.00076065186660822 mirMAP -0.570530613417457 3.06999031128998e-16 NA NA NA hsa-miR-135b-5p PPP1R12C 2.80066701698235 2.12546333413447e-11 -0.687323762239744 3.43111369936276e-06 miRNATAP -0.17237782069457 1.47834895949963e-16 NA NA NA hsa-miR-146b-3p PPP1R12C 2.08650140817622 5.3293570720033e-22 -0.687323762239744 3.43111369936276e-06 miRNATAP -0.29008959422724 7.92964842439768e-15 NA NA NA hsa-miR-196b-5p PPP1R16B 4.51951031652328 7.04026169031626e-18 -0.43305073797425 0.0797628160125177 miRNATAP -0.122767356780058 3.64874637436446e-06 NA NA NA hsa-miR-21-5p PPP1R16B 2.21515015440792 6.0468197386674e-49 -0.43305073797425 0.0797628160125177 mirMAP -0.182496035865994 0.0302456292273985 NA NA NA hsa-miR-192-5p PPP1R18 2.0867723747501 3.57854249239079e-08 0.0679340646748354 0.656374261269267 MirTarget -0.152348147552209 3.85006774165065e-11 NA NA NA hsa-miR-200b-3p PPP1R18 2.06025765178663 3.07718049337497e-10 0.0679340646748354 0.656374261269267 MirTarget;TargetScan -0.20881215477652 8.80771050099062e-16 NA NA NA hsa-miR-146b-3p PPP1R3F 2.08650140817622 5.3293570720033e-22 -0.646509003789962 0.00017939261534721 miRNATAP -0.206401604678975 4.20985194502818e-06 NA NA NA hsa-miR-200a-3p PPP1R9A 2.02394729844446 2.21240501925011e-08 -0.902560277535807 0.0425430977023791 mirMAP -0.245764967669575 0.00074872033193811 NA NA NA hsa-miR-200b-3p PPP1R9A 2.06025765178663 3.07718049337497e-10 -0.902560277535807 0.0425430977023791 TargetScan -0.270760624645925 0.00071561366648627 NA NA NA hsa-miR-335-3p PPP1R9A 2.29463721765513 4.1956113745077e-18 -0.902560277535807 0.0425430977023791 mirMAP -0.369856263100604 0.000111883180832542 NA NA NA hsa-miR-192-5p PPP2R2C 2.0867723747501 3.57854249239079e-08 -0.958837674641367 0.0742814866895039 mirMAP -0.466957895421551 1.47582848585611e-08 NA NA NA hsa-miR-194-5p PPP2R2C 2.24386881692218 9.35116329002209e-11 -0.958837674641367 0.0742814866895039 miRNATAP -0.503596467198651 1.66655805533143e-08 NA NA NA hsa-miR-200b-3p PPP2R2C 2.06025765178663 3.07718049337497e-10 -0.958837674641367 0.0742814866895039 TargetScan -0.341920658891564 0.000391136109564967 NA NA NA hsa-miR-146b-5p PPP3CB 2.23105707690238 3.83997814011313e-23 -0.422780562757183 4.51344710656914e-05 miRanda -0.164512260559993 6.69154707753253e-11 NA NA NA hsa-miR-335-3p PPP4R4 2.29463721765513 4.1956113745077e-18 -1.46030697585737 0.000177963433539933 mirMAP -0.246885954708317 0.00372291014209053 NA NA NA hsa-miR-135b-5p PRDM11 2.80066701698235 2.12546333413447e-11 -0.251933053201233 0.155113517654083 mirMAP -0.108750176503403 2.36840420397965e-05 NA NA NA hsa-miR-200a-5p PRDM11 2.19152245759943 3.17968183522514e-11 -0.251933053201233 0.155113517654083 miRNATAP -0.244126708865637 2.30402115685523e-16 NA NA NA hsa-miR-18a-5p PRDM2 2.04701000113742 1.30593450319289e-12 -0.257939992999551 0.00720663564582894 mirMAP -0.116262567066719 6.88928175182812e-10 NA NA NA hsa-miR-146b-5p PRDM5 2.23105707690238 3.83997814011313e-23 -1.09018347953033 0.000136526763105642 miRanda -0.544637309761906 1.75874215323251e-15 NA NA NA hsa-miR-335-3p PRDM5 2.29463721765513 4.1956113745077e-18 -1.09018347953033 0.000136526763105642 mirMAP -0.381617531805471 3.12065525052125e-10 NA NA NA hsa-miR-146b-5p PRELP 2.23105707690238 3.83997814011313e-23 -1.28817252567088 0.00269811496293889 mirMAP -0.682345732590959 6.03523148282697e-11 NA NA NA hsa-miR-200a-3p PRELP 2.02394729844446 2.21240501925011e-08 -1.28817252567088 0.00269811496293889 mirMAP -0.71917450747561 1.05468054889721e-29 NA NA NA hsa-miR-92a-1-5p PRELP 2.04820501765632 9.32117486799495e-13 -1.28817252567088 0.00269811496293889 mirMAP -0.69848532890826 1.82926223226055e-16 NA NA NA hsa-miR-192-5p PRICKLE1 2.0867723747501 3.57854249239079e-08 -0.111521563557497 0.670884828618259 miRNAWalker2_validate -0.287669113783684 2.62804395951269e-13 NA NA NA hsa-miR-18a-5p PRICKLE2 2.04701000113742 1.30593450319289e-12 -1.10520729121812 0.000108388577025068 MirTarget -0.6317841942329 9.42700264095972e-35 NA NA NA hsa-miR-194-5p PRICKLE2 2.24386881692218 9.35116329002209e-11 -1.10520729121812 0.000108388577025068 miRNATAP -0.479817287738785 2.89054539067797e-27 NA NA NA hsa-miR-21-5p PRICKLE2 2.21515015440792 6.0468197386674e-49 -1.10520729121812 0.000108388577025068 miRNAWalker2_validate;MirTarget -0.608807390651799 1.54800519379245e-10 NA NA NA hsa-miR-335-3p PRICKLE2 2.29463721765513 4.1956113745077e-18 -1.10520729121812 0.000108388577025068 mirMAP -0.521739130714876 4.19724172877542e-19 NA NA NA hsa-miR-335-3p PRIMA1 2.29463721765513 4.1956113745077e-18 -3.86727803633481 1.54776071591583e-11 mirMAP -1.1605186305699 2.03318946288278e-22 NA NA NA hsa-miR-146b-5p PRKAA2 2.23105707690238 3.83997814011313e-23 -2.4618359528533 1.10256665464061e-06 MirTarget -1.03034867508204 1.77551416794156e-17 NA NA NA hsa-miR-192-5p PRKAA2 2.0867723747501 3.57854249239079e-08 -2.4618359528533 1.10256665464061e-06 miRNAWalker2_validate -0.689798430456064 5.66854629636252e-20 NA NA NA hsa-miR-200a-3p PRKAA2 2.02394729844446 2.21240501925011e-08 -2.4618359528533 1.10256665464061e-06 mirMAP -0.717466896737305 1.00719810060195e-19 NA NA NA hsa-miR-200b-3p PRKAA2 2.06025765178663 3.07718049337497e-10 -2.4618359528533 1.10256665464061e-06 MirTarget -0.79671854651386 3.19149069649392e-20 NA NA NA hsa-miR-335-3p PRKAA2 2.29463721765513 4.1956113745077e-18 -2.4618359528533 1.10256665464061e-06 MirTarget -0.834623629449378 3.40669285115076e-15 NA NA NA hsa-miR-141-5p PRKAB2 2.13747696823946 1.73124674554872e-11 -0.367111274928678 0.0137111089812302 MirTarget -0.192714557977022 2.73194405893716e-13 NA NA NA hsa-miR-21-5p PRKAB2 2.21515015440792 6.0468197386674e-49 -0.367111274928678 0.0137111089812302 miRNAWalker2_validate -0.237416078773294 1.9957106446764e-06 NA NA NA hsa-miR-92a-1-5p PRKAB2 2.04820501765632 9.32117486799495e-13 -0.367111274928678 0.0137111089812302 MirTarget -0.171083664528123 1.55351251788116e-08 NA NA NA hsa-miR-146b-5p PRKACA 2.23105707690238 3.83997814011313e-23 -0.254759714806418 0.00120223663341481 PITA -0.101906530501573 1.08208425196835e-07 NA NA NA hsa-miR-146b-5p PRKACB 2.23105707690238 3.83997814011313e-23 -0.78544048113582 8.15272293615053e-05 miRanda -0.222335190553625 7.68995540057384e-06 NA NA NA hsa-miR-183-5p PRKACB 2.08412478942637 1.08931431254487e-10 -0.78544048113582 8.15272293615053e-05 MirTarget -0.292292744899958 3.20129643235052e-17 NA NA NA hsa-miR-18a-5p PRKACB 2.04701000113742 1.30593450319289e-12 -0.78544048113582 8.15272293615053e-05 miRNATAP -0.276164612892176 2.02423419558116e-12 NA NA NA hsa-miR-200a-3p PRKACB 2.02394729844446 2.21240501925011e-08 -0.78544048113582 8.15272293615053e-05 MirTarget;miRNATAP -0.230161657673416 3.98047541676119e-13 NA NA NA hsa-miR-200b-3p PRKACB 2.06025765178663 3.07718049337497e-10 -0.78544048113582 8.15272293615053e-05 MirTarget;TargetScan -0.246879516070806 1.51468418809723e-12 NA NA NA hsa-miR-192-5p PRKAR1A 2.0867723747501 3.57854249239079e-08 -0.0626576748573413 0.503137741080174 miRNAWalker2_validate -0.100024379295753 7.72049910918392e-13 NA NA NA hsa-miR-200b-3p PRKAR1A 2.06025765178663 3.07718049337497e-10 -0.0626576748573413 0.503137741080174 TargetScan -0.105267398145428 7.36823437723296e-11 NA NA NA hsa-miR-200b-3p PRKAR2B 2.06025765178663 3.07718049337497e-10 -1.74491251131701 1.12121385516986e-10 TargetScan -0.504451059563918 1.37112574474705e-28 NA NA NA hsa-miR-335-3p PRKAR2B 2.29463721765513 4.1956113745077e-18 -1.74491251131701 1.12121385516986e-10 mirMAP -0.493971680187175 4.29724118194308e-18 NA NA NA hsa-miR-146b-5p PRKCA 2.23105707690238 3.83997814011313e-23 0.011989547805439 0.942502741250812 mirMAP -0.153446820240124 0.000184746526922487 NA NA NA hsa-miR-183-5p PRKCA 2.08412478942637 1.08931431254487e-10 0.011989547805439 0.942502741250812 miRNATAP -0.164389215726407 2.54415883337075e-08 NA NA NA hsa-miR-200b-3p PRKCA 2.06025765178663 3.07718049337497e-10 0.011989547805439 0.942502741250812 TargetScan -0.108241426571207 0.000262578924015237 NA NA NA hsa-miR-141-5p PRKCB 2.13747696823946 1.73124674554872e-11 -1.31309531210577 2.09887708617144e-05 mirMAP -0.533489005918096 8.96424723395829e-24 NA NA NA hsa-miR-146b-5p PRKCB 2.23105707690238 3.83997814011313e-23 -1.31309531210577 2.09887708617144e-05 mirMAP -0.153760705978047 0.0498603039744559 NA NA NA hsa-miR-194-5p PRKCB 2.24386881692218 9.35116329002209e-11 -1.31309531210577 2.09887708617144e-05 miRNATAP -0.323196162493343 3.81053633148988e-10 NA NA NA hsa-miR-200b-3p PRKCB 2.06025765178663 3.07718049337497e-10 -1.31309531210577 2.09887708617144e-05 MirTarget -0.497565132044805 1.71366823187318e-21 NA NA NA hsa-miR-335-3p PRKCB 2.29463721765513 4.1956113745077e-18 -1.31309531210577 2.09887708617144e-05 mirMAP -0.543040838922981 1.64126163527148e-17 NA NA NA hsa-miR-146b-5p PRKCE 2.23105707690238 3.83997814011313e-23 -0.403145114198355 0.000555635541398392 miRanda;miRNATAP -0.176319088649806 5.49530368151038e-10 NA NA NA hsa-miR-200a-3p PRKCE 2.02394729844446 2.21240501925011e-08 -0.403145114198355 0.000555635541398392 miRNATAP -0.107728252728532 9.9520859955991e-09 NA NA NA hsa-miR-21-5p PRKCE 2.21515015440792 6.0468197386674e-49 -0.403145114198355 0.000555635541398392 miRNAWalker2_validate -0.222499913706839 1.08892726886949e-08 NA NA NA hsa-miR-200a-3p PRKD1 2.02394729844446 2.21240501925011e-08 -0.466152719762968 0.0358252764241339 MirTarget -0.357821262133509 2.08162768881514e-27 NA NA NA hsa-miR-135b-5p PRKD3 2.80066701698235 2.12546333413447e-11 -0.32115837201335 0.0275797017891455 MirTarget -0.103867171796674 8.2327332568589e-07 NA NA NA hsa-miR-192-5p PRKD3 2.0867723747501 3.57854249239079e-08 -0.32115837201335 0.0275797017891455 miRNAWalker2_validate;MirTarget -0.142357880982247 1.28654242154409e-10 NA NA NA hsa-miR-335-3p PRKD3 2.29463721765513 4.1956113745077e-18 -0.32115837201335 0.0275797017891455 mirMAP -0.101236236775924 0.00127397878808167 NA NA NA hsa-miR-192-5p PRKG1 2.0867723747501 3.57854249239079e-08 -0.561746760371328 0.0108057633457725 miRNATAP -0.298820802758652 1.96509503165997e-20 NA NA NA hsa-miR-200b-3p PRKG1 2.06025765178663 3.07718049337497e-10 -0.561746760371328 0.0108057633457725 TargetScan -0.415373394881215 7.75966836416119e-32 NA NA NA hsa-miR-21-5p PRKG1 2.21515015440792 6.0468197386674e-49 -0.561746760371328 0.0108057633457725 mirMAP -0.365625993525984 7.57929400288071e-07 NA NA NA hsa-miR-335-3p PRKG1 2.29463721765513 4.1956113745077e-18 -0.561746760371328 0.0108057633457725 mirMAP -0.350584607191111 1.39587900734866e-14 NA NA NA hsa-miR-935 PRKG2 2.321600496365 1.00042201726114e-07 -1.12345851835525 0.00330393158514995 MirTarget -0.172081634596726 0.00189102336664097 NA NA NA hsa-miR-146b-5p PRNP 2.23105707690238 3.83997814011313e-23 -0.769694673212605 6.60491278620587e-05 miRanda -0.341610239658861 2.33801589048306e-13 NA NA NA hsa-miR-192-5p PRNP 2.0867723747501 3.57854249239079e-08 -0.769694673212605 6.60491278620587e-05 miRNAWalker2_validate -0.330216253180879 1.13124609833152e-34 NA NA NA hsa-miR-335-3p PROS1 2.29463721765513 4.1956113745077e-18 -0.313033556295011 0.146068005460915 mirMAP -0.181274942174162 8.6186174998366e-05 NA NA NA hsa-miR-1-3p PRR14L -2.73171785118192 3.4424534921136e-12 0.428621965595346 2.51475590909074e-05 MirTarget -0.105505348710576 5.8316594714794e-13 NA NA NA hsa-miR-133a-3p PRR15L -2.63342156915404 5.72661351480585e-12 1.19246113315282 0.000204598196951007 MirTarget -0.209131587067864 2.1689315324033e-05 NA NA NA hsa-miR-200b-3p PRRG3 2.06025765178663 3.07718049337497e-10 -0.948195172898303 0.008851067571608 mirMAP -0.456477644271931 3.68916935066529e-13 NA NA NA hsa-miR-335-3p PRRG3 2.29463721765513 4.1956113745077e-18 -0.948195172898303 0.008851067571608 MirTarget;mirMAP -0.34934289532758 6.96934510017134e-06 NA NA NA hsa-miR-146b-5p PRRT1 2.23105707690238 3.83997814011313e-23 -0.726144370691418 1.86816227623787e-05 miRanda -0.298301461404525 3.97981645297768e-13 NA NA NA hsa-miR-200a-3p PRRT2 2.02394729844446 2.21240501925011e-08 -0.308456265745953 0.1443804583118 mirMAP -0.207694375878325 6.79690780628567e-10 NA NA NA hsa-miR-92a-1-5p PRRT2 2.04820501765632 9.32117486799495e-13 -0.308456265745953 0.1443804583118 mirMAP -0.216912332341064 4.82019309326873e-07 NA NA NA hsa-miR-192-5p PRSS23 2.0867723747501 3.57854249239079e-08 -0.182857440489201 0.344977903609868 miRNAWalker2_validate -0.21135748848448 3.33446401420089e-13 NA NA NA hsa-miR-335-3p PRSS23 2.29463721765513 4.1956113745077e-18 -0.182857440489201 0.344977903609868 mirMAP -0.20779949962374 4.14614957987141e-07 NA NA NA hsa-miR-135b-5p PRTG 2.80066701698235 2.12546333413447e-11 -0.0504992287070438 0.858450200149841 mirMAP -0.241178482321 2.40069322825653e-09 NA NA NA hsa-miR-146b-5p PRTG 2.23105707690238 3.83997814011313e-23 -0.0504992287070438 0.858450200149841 mirMAP -0.273900148260879 8.98399085179276e-05 NA NA NA hsa-miR-196a-5p PRTG 5.05945965885472 4.48343841468539e-25 -0.0504992287070438 0.858450200149841 MirTarget;miRNATAP -0.144147417341262 7.35126401212776e-06 NA NA NA hsa-miR-196b-5p PRTG 4.51951031652328 7.04026169031626e-18 -0.0504992287070438 0.858450200149841 MirTarget;miRNATAP -0.14895013781216 8.2231627487334e-07 NA NA NA hsa-miR-200a-3p PRTG 2.02394729844446 2.21240501925011e-08 -0.0504992287070438 0.858450200149841 MirTarget;miRNATAP -0.368025602135817 3.72063478162856e-17 NA NA NA hsa-miR-335-3p PRTG 2.29463721765513 4.1956113745077e-18 -0.0504992287070438 0.858450200149841 mirMAP -0.260462308353166 1.63693899093888e-05 NA NA NA hsa-miR-183-5p PRUNE2 2.08412478942637 1.08931431254487e-10 -1.73337783953577 0.000223209263309052 miRNATAP -0.938783268722392 3.51478998447046e-35 NA NA NA hsa-miR-196a-5p PRUNE2 5.05945965885472 4.48343841468539e-25 -1.73337783953577 0.000223209263309052 miRNAWalker2_validate -0.3230115536753 1.26652016501619e-09 NA NA NA hsa-miR-146b-5p PRX 2.23105707690238 3.83997814011313e-23 -0.550672139541812 0.000773270264703616 PITA;miRNATAP -0.222133312059713 3.38022798563019e-08 NA NA NA hsa-miR-146b-3p PSD 2.08650140817622 5.3293570720033e-22 -1.87603072042249 5.310519350043e-06 miRNATAP -0.683513652862121 1.12220768555998e-10 NA NA NA hsa-miR-141-5p PSD3 2.13747696823946 1.73124674554872e-11 -0.440931865796788 0.0127932409839404 mirMAP -0.107163944282325 0.00103741352239471 NA NA NA hsa-miR-335-3p PSD3 2.29463721765513 4.1956113745077e-18 -0.440931865796788 0.0127932409839404 mirMAP -0.138017313533736 0.000299696158866279 NA NA NA hsa-miR-200b-3p PSIP1 2.06025765178663 3.07718049337497e-10 -0.0052613598177258 0.968971847932796 MirTarget;TargetScan -0.134449489520673 1.35574947551006e-08 NA NA NA hsa-miR-133a-3p PTBP1 -2.63342156915404 5.72661351480585e-12 0.634826196068765 5.91015845239295e-13 MirTarget -0.134366898221912 6.44043919000177e-26 NA NA NA hsa-miR-141-5p PTBP2 2.13747696823946 1.73124674554872e-11 -0.26638936428747 0.119993496444284 miRNATAP -0.305527642671551 1.53039425265892e-26 NA NA NA hsa-miR-192-5p PTBP2 2.0867723747501 3.57854249239079e-08 -0.26638936428747 0.119993496444284 miRNAWalker2_validate -0.240454028254884 2.77303443605547e-22 NA NA NA hsa-miR-146b-5p PTCH1 2.23105707690238 3.83997814011313e-23 -0.0998087706005091 0.617896719568664 miRanda -0.133562784684566 0.00727837005122458 NA NA NA hsa-miR-21-5p PTCH1 2.21515015440792 6.0468197386674e-49 -0.0998087706005091 0.617896719568664 mirMAP -0.167122250972174 0.0137967172651214 NA NA NA hsa-miR-135b-5p PTCHD1 2.80066701698235 2.12546333413447e-11 -2.90717877329561 5.21593618536946e-08 mirMAP -0.622890738105232 2.93626951060136e-16 NA NA NA hsa-miR-146b-3p PTCHD1 2.08650140817622 5.3293570720033e-22 -2.90717877329561 5.21593618536946e-08 MirTarget -1.09796733344217 5.24980867962069e-16 NA NA NA hsa-miR-200a-3p PTCHD1 2.02394729844446 2.21240501925011e-08 -2.90717877329561 5.21593618536946e-08 mirMAP -0.870697343934616 1.37949923297377e-26 NA NA NA hsa-miR-21-5p PTCHD1 2.21515015440792 6.0468197386674e-49 -2.90717877329561 5.21593618536946e-08 mirMAP -1.29634744736695 3.82281100964424e-13 NA NA NA hsa-miR-335-3p PTCHD1 2.29463721765513 4.1956113745077e-18 -2.90717877329561 5.21593618536946e-08 mirMAP -0.977765976663306 1.32078629232585e-18 NA NA NA hsa-miR-18a-5p PTEN 2.04701000113742 1.30593450319289e-12 -0.187156334149252 0.0774777059361541 miRNAWalker2_validate;miRTarBase -0.100748931792874 1.71536361157568e-06 24681249;27291152 However higher levels of the miR-17~92 cluster switched from PTEN to oncogenes including Ctnnb1 β-catenin via miR-18a which resulted in inhibition of tumor growth and metastasis;miR 18a promotes cell proliferation of esophageal squamous cell carcinoma cells by increasing cylin D1 via regulating PTEN PI3K AKT mTOR signaling axis metastasis; colon cancer;esophageal cancer hsa-miR-200b-3p PTGDR 2.06025765178663 3.07718049337497e-10 -0.687281185684806 0.0141390468328478 TargetScan -0.240164878138216 1.47057607004593e-06 NA NA NA hsa-miR-146b-5p PTGER2 2.23105707690238 3.83997814011313e-23 -0.967442999580746 0.000490436068580175 miRanda -0.271618739005178 8.9387947814903e-05 NA NA NA hsa-miR-335-3p PTGER3 2.29463721765513 4.1956113745077e-18 -1.53305866763986 2.98689746760368e-06 mirMAP -0.508098096421782 2.09469065218048e-13 NA NA NA hsa-miR-146b-5p PTGER4 2.23105707690238 3.83997814011313e-23 -0.896383320155651 4.76929150024871e-05 miRanda -0.160530525138899 0.00390620322300486 NA NA NA hsa-miR-146b-5p PTGFR 2.23105707690238 3.83997814011313e-23 -0.233414407535669 0.454209756675319 miRanda -0.221300517987872 0.0043509957333934 NA NA NA hsa-miR-21-5p PTGFR 2.21515015440792 6.0468197386674e-49 -0.233414407535669 0.454209756675319 miRNAWalker2_validate -0.326004575118758 0.00201691145355239 NA NA NA hsa-miR-18a-5p PTGFRN 2.04701000113742 1.30593450319289e-12 0.347748054784637 0.0111841141940863 MirTarget;miRNATAP -0.158624532635358 4.7943259913718e-09 NA NA NA hsa-miR-146b-5p PTGS1 2.23105707690238 3.83997814011313e-23 -1.86379706848248 1.06731086101655e-15 miRNAWalker2_validate -0.448232959823284 1.82874449813464e-14 NA NA NA hsa-miR-196a-5p PTGS1 5.05945965885472 4.48343841468539e-25 -1.86379706848248 1.06731086101655e-15 miRNAWalker2_validate -0.241016016825071 7.3502839197723e-20 NA NA NA hsa-miR-196b-5p PTGS1 4.51951031652328 7.04026169031626e-18 -1.86379706848248 1.06731086101655e-15 miRNAWalker2_validate -0.204596316610976 6.72526389786578e-16 NA NA NA hsa-miR-200a-5p PTGS1 2.19152245759943 3.17968183522514e-11 -1.86379706848248 1.06731086101655e-15 mirMAP -0.328781671953644 2.57143187361901e-15 NA NA NA hsa-miR-146b-5p PTGS2 2.23105707690238 3.83997814011313e-23 0.00805602322749532 0.981456994390787 miRanda -0.229212864549947 0.00791099874690068 NA NA NA hsa-miR-200b-3p PTHLH 2.06025765178663 3.07718049337497e-10 -0.698481509843736 0.00799227292455291 MirTarget;TargetScan -0.340100291189722 8.04685634951928e-14 NA NA NA hsa-miR-18a-5p PTP4A3 2.04701000113742 1.30593450319289e-12 0.37089836851384 0.0714256316138787 MirTarget -0.139492129669882 0.000779992154012068 NA NA NA hsa-miR-192-5p PTP4A3 2.0867723747501 3.57854249239079e-08 0.37089836851384 0.0714256316138787 miRNAWalker2_validate -0.139798326084273 1.18296157443871e-05 NA NA NA hsa-miR-194-5p PTPN13 2.24386881692218 9.35116329002209e-11 -1.20755288636418 4.62853401871777e-06 miRNAWalker2_validate;miRTarBase -0.447360635180318 1.51375170838027e-27 NA NA NA hsa-miR-200b-3p PTPN13 2.06025765178663 3.07718049337497e-10 -1.20755288636418 4.62853401871777e-06 TargetScan -0.433663457968814 2.2906897923458e-22 NA NA NA hsa-miR-200b-3p PTPN14 2.06025765178663 3.07718049337497e-10 0.144321960759363 0.345946539624122 MirTarget;TargetScan -0.25572680274256 2.93805336168299e-24 NA NA NA hsa-miR-335-3p PTPN14 2.29463721765513 4.1956113745077e-18 0.144321960759363 0.345946539624122 MirTarget -0.103047251900213 0.00174315880057295 NA NA NA hsa-miR-200b-3p PTPN21 2.06025765178663 3.07718049337497e-10 -0.58065256518922 1.06468190774833e-05 TargetScan -0.177123992747243 1.07042797357042e-14 NA NA NA hsa-miR-335-3p PTPN21 2.29463721765513 4.1956113745077e-18 -0.58065256518922 1.06468190774833e-05 mirMAP -0.140494528784967 7.65106133939671e-07 NA NA NA hsa-miR-335-3p PTPRC 2.29463721765513 4.1956113745077e-18 0.173008622676843 0.511073100378589 MirTarget -0.156401926962125 0.00589113843763331 NA NA NA hsa-miR-135b-5p PTPRD 2.80066701698235 2.12546333413447e-11 -1.00502953098866 0.000637604436440412 miRNATAP -0.231589875792518 5.899906808236e-08 NA NA NA hsa-miR-194-5p PTPRD 2.24386881692218 9.35116329002209e-11 -1.00502953098866 0.000637604436440412 miRNATAP -0.223067428510089 7.47499419735159e-06 NA NA NA hsa-miR-200a-3p PTPRD 2.02394729844446 2.21240501925011e-08 -1.00502953098866 0.000637604436440412 miRNAWalker2_validate;miRNATAP -0.271906682595162 1.09246277403848e-08 NA NA NA hsa-miR-200b-3p PTPRD 2.06025765178663 3.07718049337497e-10 -1.00502953098866 0.000637604436440412 miRNAWalker2_validate -0.288688828311511 3.45579589252849e-08 NA NA NA hsa-miR-335-3p PTPRD 2.29463721765513 4.1956113745077e-18 -1.00502953098866 0.000637604436440412 mirMAP -0.214105351641975 0.000815186408603789 NA NA NA hsa-miR-935 PTPRD 2.321600496365 1.00042201726114e-07 -1.00502953098866 0.000637604436440412 PITA -0.182277083648794 1.69901375896796e-05 NA NA NA hsa-miR-935 PTPRS 2.321600496365 1.00042201726114e-07 -1.30785949402664 1.50281242866379e-06 PITA;miRNATAP -0.197546708092591 5.0431864415456e-07 NA NA NA hsa-miR-135b-5p PTPRT 2.80066701698235 2.12546333413447e-11 -0.907265605799675 0.0372664951342187 mirMAP -0.319350508845152 4.06047315237432e-07 NA NA NA hsa-miR-21-5p PTPRT 2.21515015440792 6.0468197386674e-49 -0.907265605799675 0.0372664951342187 mirMAP -0.574923123772829 9.44035643684869e-05 NA NA NA hsa-miR-935 PTPRT 2.321600496365 1.00042201726114e-07 -0.907265605799675 0.0372664951342187 PITA;mirMAP -0.359029976369864 5.03477331642728e-09 NA NA NA hsa-miR-146b-5p PTPRZ1 2.23105707690238 3.83997814011313e-23 -2.75323049688382 2.67429001839694e-08 miRanda -0.794644992163652 9.91018571811385e-11 NA NA NA hsa-miR-200b-3p PTPRZ1 2.06025765178663 3.07718049337497e-10 -2.75323049688382 2.67429001839694e-08 MirTarget -0.440357477171887 1.05873968350879e-06 NA NA NA hsa-miR-21-5p PTX3 2.21515015440792 6.0468197386674e-49 -1.43718463297197 7.26624158154991e-07 miRNAWalker2_validate -0.680140526369636 2.07565753759716e-12 NA NA NA hsa-miR-21-5p PURA 2.21515015440792 6.0468197386674e-49 -0.330747450626133 0.000135621233435024 miRNAWalker2_validate -0.124600602874901 2.02760036867837e-05 NA NA NA hsa-miR-335-3p PURA 2.29463721765513 4.1956113745077e-18 -0.330747450626133 0.000135621233435024 mirMAP -0.119636258981734 4.59753059737469e-11 NA NA NA hsa-miR-192-5p PXDC1 2.0867723747501 3.57854249239079e-08 -0.544516484801669 0.000990453611649091 miRNAWalker2_validate -0.113652947287408 1.05920523358882e-05 NA NA NA hsa-miR-146b-5p PYGO1 2.23105707690238 3.83997814011313e-23 -0.577919573490782 0.0779977225123871 mirMAP -0.489358503906662 7.6707784358377e-10 NA NA NA hsa-miR-200b-3p PYGO1 2.06025765178663 3.07718049337497e-10 -0.577919573490782 0.0779977225123871 mirMAP -0.513989094655899 7.70548205890669e-21 NA NA NA hsa-miR-21-5p PYGO1 2.21515015440792 6.0468197386674e-49 -0.577919573490782 0.0779977225123871 mirMAP -0.481773033773768 1.25140599810157e-05 NA NA NA hsa-miR-335-3p PYGO1 2.29463721765513 4.1956113745077e-18 -0.577919573490782 0.0779977225123871 mirMAP -0.377409306368992 5.62193515800567e-08 NA NA NA hsa-miR-92a-1-5p PYGO1 2.04820501765632 9.32117486799495e-13 -0.577919573490782 0.0779977225123871 MirTarget -0.433668515414507 4.62762484877431e-11 NA NA NA hsa-miR-935 PYGO1 2.321600496365 1.00042201726114e-07 -0.577919573490782 0.0779977225123871 MirTarget -0.270455787062077 4.65012516621401e-09 NA NA NA hsa-miR-18a-5p QKI 2.04701000113742 1.30593450319289e-12 -0.332523081792703 0.0411054129206581 mirMAP -0.267866627369979 5.21158780043816e-18 NA NA NA hsa-miR-200a-5p QKI 2.19152245759943 3.17968183522514e-11 -0.332523081792703 0.0411054129206581 mirMAP -0.279298759584044 2.2128346343507e-26 NA NA NA hsa-miR-200b-3p QKI 2.06025765178663 3.07718049337497e-10 -0.332523081792703 0.0411054129206581 TargetScan -0.290326831854982 4.74685160856375e-28 NA NA NA hsa-miR-335-3p QKI 2.29463721765513 4.1956113745077e-18 -0.332523081792703 0.0411054129206581 mirMAP -0.243987817533663 4.85316660807279e-13 NA NA NA hsa-miR-146b-5p QSOX1 2.23105707690238 3.83997814011313e-23 -0.564638727105883 0.00110443995840348 miRanda -0.108501160226148 0.0125933588255129 NA NA NA hsa-miR-1-3p RAB11FIP1 -2.73171785118192 3.4424534921136e-12 0.620704724849096 0.00129535994417007 MirTarget -0.157813696276044 2.33512845422121e-08 NA NA NA hsa-miR-183-5p RAB11FIP2 2.08412478942637 1.08931431254487e-10 -0.259679029578217 0.0617021736002116 miRNATAP -0.162760969989909 2.6571800034611e-11 NA NA NA hsa-miR-18a-5p RAB11FIP2 2.04701000113742 1.30593450319289e-12 -0.259679029578217 0.0617021736002116 miRNATAP -0.13017508483049 2.63843110136088e-06 NA NA NA hsa-miR-192-5p RAB11FIP2 2.0867723747501 3.57854249239079e-08 -0.259679029578217 0.0617021736002116 miRNAWalker2_validate -0.132184387341565 3.88899214231502e-10 NA NA NA hsa-miR-194-5p RAB11FIP2 2.24386881692218 9.35116329002209e-11 -0.259679029578217 0.0617021736002116 MirTarget;miRNATAP -0.118330692181611 3.1468174952173e-07 NA NA NA hsa-miR-200a-3p RAB11FIP2 2.02394729844446 2.21240501925011e-08 -0.259679029578217 0.0617021736002116 MirTarget -0.142193905259261 1.12018289045023e-10 NA NA NA hsa-miR-200b-3p RAB11FIP2 2.06025765178663 3.07718049337497e-10 -0.259679029578217 0.0617021736002116 MirTarget;TargetScan -0.144162950888408 3.20530256880898e-09 NA NA NA hsa-miR-21-5p RAB11FIP2 2.21515015440792 6.0468197386674e-49 -0.259679029578217 0.0617021736002116 miRNAWalker2_validate -0.130213784529132 0.00572528163605836 NA NA NA hsa-miR-335-3p RAB11FIP2 2.29463721765513 4.1956113745077e-18 -0.259679029578217 0.0617021736002116 MirTarget;mirMAP -0.122026338969476 4.04917890141325e-05 NA NA NA hsa-miR-335-3p RAB12 2.29463721765513 4.1956113745077e-18 -0.331725395446472 0.00841506962855526 mirMAP -0.159595545868652 1.74159249722247e-09 NA NA NA hsa-miR-18a-5p RAB23 2.04701000113742 1.30593450319289e-12 -0.096112489735301 0.66521993302631 miRNAWalker2_validate -0.357609358549775 2.68209325911484e-17 NA NA NA hsa-miR-192-5p RAB23 2.0867723747501 3.57854249239079e-08 -0.096112489735301 0.66521993302631 miRNAWalker2_validate -0.341519884810975 1.45030597397005e-27 NA NA NA hsa-miR-200b-3p RAB23 2.06025765178663 3.07718049337497e-10 -0.096112489735301 0.66521993302631 TargetScan -0.405142952873887 8.39457399685435e-30 NA NA NA hsa-miR-335-3p RAB27A 2.29463721765513 4.1956113745077e-18 -1.09798450633557 1.30567162119781e-13 mirMAP -0.267713002009758 2.65151498759254e-17 NA NA NA hsa-miR-146b-5p RAB30 2.23105707690238 3.83997814011313e-23 -1.42442211692912 3.65381677106471e-13 mirMAP -0.221747576891302 1.1814769549293e-05 NA NA NA hsa-miR-200a-3p RAB30 2.02394729844446 2.21240501925011e-08 -1.42442211692912 3.65381677106471e-13 miRNAWalker2_validate;miRNATAP -0.136257423504337 4.46555272497937e-05 NA NA NA hsa-miR-200b-3p RAB30 2.06025765178663 3.07718049337497e-10 -1.42442211692912 3.65381677106471e-13 mirMAP -0.15581480803642 2.06143329458025e-05 NA NA NA hsa-miR-21-5p RAB30 2.21515015440792 6.0468197386674e-49 -1.42442211692912 3.65381677106471e-13 mirMAP -0.413050570362964 1.11712478338868e-09 NA NA NA hsa-miR-335-3p RAB30 2.29463721765513 4.1956113745077e-18 -1.42442211692912 3.65381677106471e-13 MirTarget -0.271888897090337 2.65505432298378e-10 NA NA NA hsa-miR-335-3p RAB31 2.29463721765513 4.1956113745077e-18 0.36372377872883 0.0598794964924342 mirMAP -0.216658326079326 1.25601139811018e-07 NA NA NA hsa-miR-141-5p RAB32 2.13747696823946 1.73124674554872e-11 -0.257879696037239 0.183742885296481 MirTarget -0.11590937279909 0.00114985108202206 NA NA NA hsa-miR-200a-3p RAB36 2.02394729844446 2.21240501925011e-08 0.20369952242502 0.375390799095336 mirMAP -0.146486005222724 8.78008916799449e-05 NA NA NA hsa-miR-200b-3p RAB37 2.06025765178663 3.07718049337497e-10 -1.20320026232116 2.2252385940338e-06 TargetScan -0.101005535927286 0.0308450646470225 NA NA NA hsa-miR-200a-3p RAB38 2.02394729844446 2.21240501925011e-08 -0.804993952002909 0.000941988188511324 miRNATAP -0.117718778063659 0.00341133689112853 NA NA NA hsa-miR-335-3p RAB39B 2.29463721765513 4.1956113745077e-18 -1.10670468934816 0.000215382178403974 MirTarget -0.294154387087295 5.17448420117023e-06 NA NA NA hsa-miR-935 RAB39B 2.321600496365 1.00042201726114e-07 -1.10670468934816 0.000215382178403974 MirTarget -0.172987175545855 6.35383421020397e-05 NA NA NA hsa-miR-200a-3p RAB3C 2.02394729844446 2.21240501925011e-08 -1.07459718698808 0.0148779758106164 mirMAP -0.303048785253962 2.5501157824988e-05 NA NA NA hsa-miR-335-3p RAB3C 2.29463721765513 4.1956113745077e-18 -1.07459718698808 0.0148779758106164 mirMAP -0.397180449083818 2.82450680428562e-05 NA NA NA hsa-miR-194-5p RAB6B 2.24386881692218 9.35116329002209e-11 -1.20336252314016 2.74022582273913e-07 miRNATAP -0.289217297916556 9.63906282888392e-14 NA NA NA hsa-miR-183-5p RAB8B 2.08412478942637 1.08931431254487e-10 0.0285185413556936 0.801769805123289 MirTarget;miRNATAP -0.11460122043261 1.14608067852922e-08 NA NA NA hsa-miR-183-5p RAB9B 2.08412478942637 1.08931431254487e-10 -1.64127232803465 2.08021776444596e-07 miRNATAP -0.687601647744498 9.99077307309974e-43 NA NA NA hsa-miR-146b-5p RABGAP1 2.23105707690238 3.83997814011313e-23 -0.106752464617506 0.378462368364444 miRanda;miRNATAP -0.179721372976928 7.68212501842651e-10 NA NA NA hsa-miR-18a-5p RABGAP1 2.04701000113742 1.30593450319289e-12 -0.106752464617506 0.378462368364444 MirTarget;miRNATAP -0.176770939268216 3.26482252098566e-14 NA NA NA hsa-miR-192-5p RABGAP1 2.0867723747501 3.57854249239079e-08 -0.106752464617506 0.378462368364444 miRNAWalker2_validate;MirTarget;miRNATAP -0.193308534942298 2.57444474829562e-30 NA NA NA hsa-miR-200a-3p RABGAP1 2.02394729844446 2.21240501925011e-08 -0.106752464617506 0.378462368364444 miRNATAP -0.172759904023828 4.72884433257206e-21 NA NA NA hsa-miR-21-5p RABGAP1 2.21515015440792 6.0468197386674e-49 -0.106752464617506 0.378462368364444 miRNAWalker2_validate -0.163996670734361 5.38478686992387e-05 NA NA NA hsa-miR-1-3p RAD54B -2.73171785118192 3.4424534921136e-12 1.34152243302311 7.23209113540869e-16 MirTarget -0.230143217151427 2.41716431443807e-21 NA NA NA hsa-miR-192-5p RADIL 2.0867723747501 3.57854249239079e-08 -1.62758052303071 7.68103486572053e-09 miRNAWalker2_validate -0.427271623557567 8.95367396528041e-25 NA NA NA hsa-miR-146b-3p RAF1 2.08650140817622 5.3293570720033e-22 -0.44281915065078 1.6619263967657e-11 MirTarget;PITA;miRNATAP -0.101453721067746 3.29913513582506e-09 NA NA NA hsa-miR-335-3p RAP1A 2.29463721765513 4.1956113745077e-18 -0.92854527745901 1.26897835292689e-15 mirMAP -0.223790443695013 1.31593513050956e-19 NA NA NA hsa-miR-935 RAP1A 2.321600496365 1.00042201726114e-07 -0.92854527745901 1.26897835292689e-15 miRNATAP -0.121077537966349 9.27340772591797e-13 NA NA NA hsa-miR-200b-3p RAPGEF1 2.06025765178663 3.07718049337497e-10 -0.0152957002202374 0.878400557041415 TargetScan -0.100367470326615 8.44449291873679e-09 NA NA NA hsa-miR-146b-5p RAPGEF3 2.23105707690238 3.83997814011313e-23 -0.767003460649887 5.08860635131723e-07 miRanda -0.163220226527444 2.17526280641781e-05 NA NA NA hsa-miR-335-3p RAPGEF3 2.29463721765513 4.1956113745077e-18 -0.767003460649887 5.08860635131723e-07 mirMAP -0.211067452639435 9.34141668804363e-11 NA NA NA hsa-miR-146b-5p RARB 2.23105707690238 3.83997814011313e-23 -0.824546396136413 1.67331828630351e-05 PITA;miRanda;miRNATAP -0.227205824557134 1.96619651512677e-06 27011326 Direct interaction between miRs and RARB was determined in the luciferase assay and further confirmed in cell lines where overexpression of miR-146a-5p and miR-146b-5p caused a 31% and 33% decrease in endogenous RARB mRNA levels thyroid cancer hsa-miR-200a-3p RARB 2.02394729844446 2.21240501925011e-08 -0.824546396136413 1.67331828630351e-05 miRNATAP -0.230873705582459 3.21322709489902e-14 NA NA NA hsa-miR-935 RARB 2.321600496365 1.00042201726114e-07 -0.824546396136413 1.67331828630351e-05 PITA;miRNATAP -0.144218615853308 1.56620834607042e-07 NA NA NA hsa-miR-200a-3p RASA4 2.02394729844446 2.21240501925011e-08 -0.702098653804009 8.48703305158542e-05 mirMAP -0.191842720909586 2.01250115548624e-11 NA NA NA hsa-miR-146b-3p RASL10B 2.08650140817622 5.3293570720033e-22 0.300494797632035 0.368635850954043 MirTarget;PITA;miRNATAP -0.199201376120521 0.0224565205007641 NA NA NA hsa-miR-141-5p RASSF2 2.13747696823946 1.73124674554872e-11 -0.273260229164372 0.2196076417753 mirMAP -0.278909875056611 1.52765109071873e-12 NA NA NA hsa-miR-200a-3p RASSF2 2.02394729844446 2.21240501925011e-08 -0.273260229164372 0.2196076417753 miRNAWalker2_validate -0.244060166615596 3.59149466603464e-12 NA NA NA hsa-miR-200b-3p RASSF2 2.06025765178663 3.07718049337497e-10 -0.273260229164372 0.2196076417753 miRNAWalker2_validate -0.252549813842515 7.110986826073e-11 NA NA NA hsa-miR-18a-5p RASSF3 2.04701000113742 1.30593450319289e-12 -0.226294581630821 0.116913602693839 miRNAWalker2_validate -0.199039300057131 1.19251429273211e-12 NA NA NA hsa-miR-192-5p RASSF8 2.0867723747501 3.57854249239079e-08 -0.121570136144733 0.655913644139023 miRNAWalker2_validate -0.376661283386746 1.63895387736148e-21 NA NA NA hsa-miR-200b-3p RASSF8 2.06025765178663 3.07718049337497e-10 -0.121570136144733 0.655913644139023 TargetScan -0.483133049279681 1.0278957185645e-27 NA NA NA hsa-miR-146b-5p RBFOX2 2.23105707690238 3.83997814011313e-23 -0.23382535811194 0.0474300848701291 mirMAP -0.170265392379567 2.52904905430828e-09 NA NA NA hsa-miR-192-5p RBFOX2 2.0867723747501 3.57854249239079e-08 -0.23382535811194 0.0474300848701291 mirMAP -0.194154501920314 1.4371922406975e-32 NA NA NA hsa-miR-200b-3p RBFOX2 2.06025765178663 3.07718049337497e-10 -0.23382535811194 0.0474300848701291 TargetScan -0.236127548907516 9.17291557021335e-38 NA NA NA hsa-miR-21-5p RBFOX2 2.21515015440792 6.0468197386674e-49 -0.23382535811194 0.0474300848701291 mirMAP -0.206833986902537 1.31706466900453e-07 NA NA NA hsa-miR-335-3p RBFOX2 2.29463721765513 4.1956113745077e-18 -0.23382535811194 0.0474300848701291 mirMAP -0.114117675381203 5.51858861003142e-06 NA NA NA hsa-miR-146b-3p RBFOX3 2.08650140817622 5.3293570720033e-22 -2.19005818118938 0.000121911420336494 mirMAP -0.99314726258334 7.62605719364136e-12 NA NA NA hsa-miR-200b-3p RBFOX3 2.06025765178663 3.07718049337497e-10 -2.19005818118938 0.000121911420336494 MirTarget;TargetScan -1.01713955020247 2.81387415801674e-27 NA NA NA hsa-miR-92a-1-5p RBFOX3 2.04820501765632 9.32117486799495e-13 -2.19005818118938 0.000121911420336494 mirMAP -0.94283153037031 7.57380132460506e-17 NA NA NA hsa-miR-335-3p RBL2 2.29463721765513 4.1956113745077e-18 -0.281923008753179 0.0025386513501511 MirTarget -0.101333197845206 3.17736538992929e-07 NA NA NA hsa-miR-146b-5p RBM11 2.23105707690238 3.83997814011313e-23 -2.04335581047901 1.11180544167625e-06 MirTarget;miRanda -0.589031351162892 1.66272809135777e-08 NA NA NA hsa-miR-335-3p RBM11 2.29463721765513 4.1956113745077e-18 -2.04335581047901 1.11180544167625e-06 MirTarget -0.517739822914737 1.01812703956286e-08 NA NA NA hsa-miR-200b-3p RBM20 2.06025765178663 3.07718049337497e-10 -1.95734925558392 5.80934241681352e-07 MirTarget;TargetScan -0.592424506178781 1.88172738438787e-18 NA NA NA hsa-miR-935 RBM20 2.321600496365 1.00042201726114e-07 -1.95734925558392 5.80934241681352e-07 mirMAP -0.329763087271521 4.66839451023147e-09 NA NA NA hsa-miR-141-5p RBMS1 2.13747696823946 1.73124674554872e-11 -0.0436443770031296 0.808758050496525 miRNATAP -0.250654124199817 1.73356757156277e-15 NA NA NA hsa-miR-183-5p RBMS1 2.08412478942637 1.08931431254487e-10 -0.0436443770031296 0.808758050496525 miRNATAP -0.253920303033411 2.46322390081689e-16 NA NA NA hsa-miR-200a-3p RBMS1 2.02394729844446 2.21240501925011e-08 -0.0436443770031296 0.808758050496525 miRNATAP -0.229791807453393 1.65119639260627e-16 NA NA NA hsa-miR-192-5p RBMS3 2.0867723747501 3.57854249239079e-08 -0.518802275066789 0.0355078319259322 MirTarget -0.3435975934114 9.5771872222385e-22 NA NA NA hsa-miR-196a-5p RBMS3 5.05945965885472 4.48343841468539e-25 -0.518802275066789 0.0355078319259322 MirTarget -0.166856531541342 1.71738218965271e-09 NA NA NA hsa-miR-196b-5p RBMS3 4.51951031652328 7.04026169031626e-18 -0.518802275066789 0.0355078319259322 MirTarget -0.20060175911805 3.92025856573125e-15 NA NA NA hsa-miR-335-3p RBMS3 2.29463721765513 4.1956113745077e-18 -0.518802275066789 0.0355078319259322 MirTarget;mirMAP -0.382614088131624 6.70102390218885e-14 NA NA NA hsa-miR-335-3p RBP1 2.29463721765513 4.1956113745077e-18 -0.913315395878153 0.00136270387176768 mirMAP -0.139730884192945 0.0248098487686243 NA NA NA hsa-miR-192-5p RBP7 2.0867723747501 3.57854249239079e-08 -1.55108469996823 2.92968464957998e-09 miRNAWalker2_validate -0.300842249818097 9.66157548801478e-14 NA NA NA hsa-miR-146b-5p RBPMS 2.23105707690238 3.83997814011313e-23 -0.791295031458187 0.000409312613672102 miRanda -0.410836751994993 2.06104465878851e-14 NA NA NA hsa-miR-335-3p RCAN2 2.29463721765513 4.1956113745077e-18 -0.330049532094766 0.15172095135038 mirMAP -0.281334452146647 6.74735274429116e-09 NA NA NA hsa-miR-192-5p RCBTB2 2.0867723747501 3.57854249239079e-08 -0.615542074181102 1.20706327268499e-05 miRNAWalker2_validate -0.203322879695303 4.82196530892446e-23 NA NA NA hsa-miR-335-3p RCBTB2 2.29463721765513 4.1956113745077e-18 -0.615542074181102 1.20706327268499e-05 mirMAP -0.196113855717998 4.60881957673822e-11 NA NA NA hsa-miR-133a-3p RCE1 -2.63342156915404 5.72661351480585e-12 0.312874009933247 0.00945187029348954 MirTarget -0.106577628865163 3.19033598793548e-09 NA NA NA hsa-miR-146b-5p RCOR3 2.23105707690238 3.83997814011313e-23 -0.119702410705573 0.230476107003849 miRanda -0.115816913916645 2.00149417304205e-06 NA NA NA hsa-miR-200b-3p RECK 2.06025765178663 3.07718049337497e-10 -1.04347373160309 9.33987268915419e-07 TargetScan -0.423201877789433 5.05302593040661e-35 NA NA NA hsa-miR-21-5p RECK 2.21515015440792 6.0468197386674e-49 -1.04347373160309 9.33987268915419e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.462770638390227 8.85041421987572e-11 18794849;19730150;20480266;22642976;25720799 Finally we showed that RECK a known tumor suppressor in gastric cancer is a bona fide target of miR-21; Taken together miR-21 may be important in the initiation and progression of gastric cancers as an oncomiR likely through regulating RECK; Our findings suggest a potential regulatory pathway in which H pylori infection upregulates expression of miR-21 which in turn downregulates RECK and then leads to the development of gastric cancer;Protein levels of tumor suppressor targets of the miRNAs were increased by antisense to miR-21 PTEN and RECK and miR-221 p27;Furthermore we identified that RECK reversion-inducing-cysteine-rich protein with kazal motifs a tumor suppressor gene was a direct target of miR-21; Our results suggest that miR-21 expression has a key role in regulating cellular processes in osteosarcoma likely through regulating RECK and may serve as a therapeutic target;miR 21 may acts as an oncomir by targeting RECK a matrix metalloproteinase regulator in prostate cancer; The micro RNA miRNA mir-21 has been shown to regulate invasiveness in cancer through translational repression of the Metaloproteinase MMP inhibitor RECK; Our aim is to investigate the levels of expression of RECK and miR-21 in PCa comparing with classical prognostic factors and disease outcome and also test if RECK is a target of miR-21 in in vitro study using PCa cell line; To determine if RECK is a target of miR-21 in prostate cancer we performed an in vitro assay with PCa cell line DU-145 transfected with pre-miR-21 and anti-miR-21; To determine miR-21 and RECK expression levels in PCa samples we performed quantitative real-time polymerase chain reaction qRT-PCR; From men who presented the second profile miR-21 overexpression and RECK underexpression 91.7% were staged pT3; Our results demonstrate RECK as a target of miR-21; We believe that miR-21 may be important in PCa progression through its regulation of RECK a known regulator of tumor cell invasion;We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase MMP inhibitors RECK and TIMP3 which are known to impact HCC progression and metastases; Finally we found that inhibition of miR-21 in murine HMGB1-overexpressing HCC xenografts led to reduced tumor MMP activity through released repression of the miR-21 targets RECK and TIMP3 which ultimately impeded tumor progression progression;;;staging;progression;metastasis;progression gastric cancer;pancreatic cancer;sarcoma;prostate cancer;liver cancer hsa-miR-335-3p RECK 2.29463721765513 4.1956113745077e-18 -1.04347373160309 9.33987268915419e-07 mirMAP -0.370086826205449 6.18884598946451e-17 NA NA NA hsa-miR-192-5p REEP1 2.0867723747501 3.57854249239079e-08 -2.11544155777275 2.02942413315448e-07 miRNAWalker2_validate -0.479953402635237 1.28696497124592e-14 NA NA NA hsa-miR-200b-3p REEP1 2.06025765178663 3.07718049337497e-10 -2.11544155777275 2.02942413315448e-07 MirTarget;TargetScan -0.616176338172447 2.09750484334052e-18 NA NA NA hsa-miR-196a-5p REEP2 5.05945965885472 4.48343841468539e-25 -1.43591098048092 4.30296016027365e-05 miRNAWalker2_validate -0.260307038283211 5.15877706417558e-11 NA NA NA hsa-miR-200a-5p REEP3 2.19152245759943 3.17968183522514e-11 -0.05001693972154 0.70192870596325 MirTarget -0.115343472559776 3.82976377506048e-07 NA NA NA hsa-miR-200b-3p RELN 2.06025765178663 3.07718049337497e-10 -2.4032593050865 9.46041009197227e-10 MirTarget;TargetScan -0.634831068527533 9.16409051000065e-21 NA NA NA hsa-miR-935 RELN 2.321600496365 1.00042201726114e-07 -2.4032593050865 9.46041009197227e-10 MirTarget;PITA;miRNATAP -0.44678689874642 8.51253935635646e-16 NA NA NA hsa-miR-146b-3p REPS2 2.08650140817622 5.3293570720033e-22 -0.101060745463859 0.602754903932931 MirTarget -0.212304969755738 2.17682368251991e-05 NA NA NA hsa-miR-146b-5p REPS2 2.23105707690238 3.83997814011313e-23 -0.101060745463859 0.602754903932931 miRanda -0.218362351550218 4.6321074573706e-06 NA NA NA hsa-miR-18a-5p REPS2 2.04701000113742 1.30593450319289e-12 -0.101060745463859 0.602754903932931 miRNATAP -0.141291807297415 0.00029130860596783 NA NA NA hsa-miR-146b-5p RERE 2.23105707690238 3.83997814011313e-23 -0.181970978434266 0.124113140521512 miRanda -0.187929758845175 3.68128986445241e-11 NA NA NA hsa-miR-194-5p RERE 2.24386881692218 9.35116329002209e-11 -0.181970978434266 0.124113140521512 miRNATAP -0.114405117962974 4.43746966556332e-09 NA NA NA hsa-miR-200b-3p RERE 2.06025765178663 3.07718049337497e-10 -0.181970978434266 0.124113140521512 miRNAWalker2_validate;miRTarBase -0.115464533256617 2.66966313806461e-08 NA NA NA hsa-miR-935 RERG 2.321600496365 1.00042201726114e-07 -1.38824246645131 5.44069155315798e-05 MirTarget;PITA;miRNATAP -0.395468854830361 8.0005324223038e-17 NA NA NA hsa-miR-192-5p RET 2.0867723747501 3.57854249239079e-08 -0.832755310542644 0.0351710970965439 miRNAWalker2_validate -0.280377047147025 4.90849064031775e-06 NA NA NA hsa-miR-196a-5p RET 5.05945965885472 4.48343841468539e-25 -0.832755310542644 0.0351710970965439 MirTarget -0.132942933937021 0.00354918843770534 NA NA NA hsa-miR-183-5p REV3L 2.08412478942637 1.08931431254487e-10 0.0648775417046759 0.622634319982209 miRNAWalker2_validate -0.121159841563941 2.43901406939581e-07 NA NA NA hsa-miR-194-5p REV3L 2.24386881692218 9.35116329002209e-11 0.0648775417046759 0.622634319982209 miRNATAP -0.122448853505927 1.82305931184491e-08 NA NA NA hsa-miR-18a-5p REXO2 2.04701000113742 1.30593450319289e-12 -0.279369830114021 0.0255930990946602 MirTarget;miRNATAP -0.110455870150354 1.01941590753983e-05 NA NA NA hsa-miR-133a-3p RFC3 -2.63342156915404 5.72661351480585e-12 1.48346755186333 4.74768972378879e-20 MirTarget -0.244784746665206 1.7096060961019e-23 NA NA NA hsa-miR-200a-3p RFTN1 2.02394729844446 2.21240501925011e-08 0.535987820378202 0.0022583456099708 MirTarget -0.169215296559743 1.90816613287312e-09 NA NA NA hsa-miR-200a-5p RFTN2 2.19152245759943 3.17968183522514e-11 -0.0201120819071681 0.894968445621802 MirTarget -0.200177350095112 6.13926967328656e-15 NA NA NA hsa-miR-200b-3p RFTN2 2.06025765178663 3.07718049337497e-10 -0.0201120819071681 0.894968445621802 MirTarget -0.20118302456019 1.05049796370213e-14 NA NA NA hsa-miR-335-3p RFTN2 2.29463721765513 4.1956113745077e-18 -0.0201120819071681 0.894968445621802 MirTarget -0.186936338556359 5.02804386228706e-09 NA NA NA hsa-miR-1-3p RFWD3 -2.73171785118192 3.4424534921136e-12 1.06784476678239 3.15654451888008e-18 MirTarget -0.159661632745911 2.22516470725485e-18 NA NA NA hsa-miR-146b-5p RFX2 2.23105707690238 3.83997814011313e-23 -0.462715626946532 0.0243262842963213 miRanda -0.245231280389327 1.23296030494336e-06 NA NA NA hsa-miR-935 RFX6 2.321600496365 1.00042201726114e-07 -1.73231808126891 0.00776641816771147 MirTarget;miRNATAP -0.319807023946901 0.000666517800727761 NA NA NA hsa-miR-135b-5p RGL1 2.80066701698235 2.12546333413447e-11 -0.442559496999595 0.0118773904815059 MirTarget -0.189958786208009 1.38045375688674e-14 NA NA NA hsa-miR-200b-3p RGL1 2.06025765178663 3.07718049337497e-10 -0.442559496999595 0.0118773904815059 MirTarget;TargetScan -0.276656234016685 6.2977174943952e-21 NA NA NA hsa-miR-335-3p RGL1 2.29463721765513 4.1956113745077e-18 -0.442559496999595 0.0118773904815059 mirMAP -0.230408750083706 4.82828388216365e-10 NA NA NA hsa-miR-146b-5p RGMB 2.23105707690238 3.83997814011313e-23 -1.27477126331245 3.57648326381644e-10 miRanda -0.420993310903252 1.44435820517315e-17 NA NA NA hsa-miR-146b-5p RGP1 2.23105707690238 3.83997814011313e-23 -0.304820293354894 0.00559539398120897 mirMAP -0.104775442107119 0.000120478450581657 NA NA NA hsa-miR-335-3p RGPD5 2.29463721765513 4.1956113745077e-18 -0.0735056839211189 0.747724365691236 mirMAP -0.173010908010003 0.000419292823453439 NA NA NA hsa-miR-335-3p RGS17 2.29463721765513 4.1956113745077e-18 -0.129858333974612 0.527795270768373 mirMAP -0.137442749087109 0.00189794698645662 NA NA NA hsa-miR-146b-3p RGS4 2.08650140817622 5.3293570720033e-22 -0.488415523283244 0.156783848894417 MirTarget;miRNATAP -0.337077960990444 0.000163020532328755 NA NA NA hsa-miR-146b-5p RGS5 2.23105707690238 3.83997814011313e-23 -1.06349143514205 1.27716115038665e-05 MirTarget;miRanda -0.420993618341942 1.23766204533451e-12 NA NA NA hsa-miR-335-3p RGS5 2.29463721765513 4.1956113745077e-18 -1.06349143514205 1.27716115038665e-05 mirMAP -0.428010991873417 1.9683254255357e-17 NA NA NA hsa-miR-200a-3p RGS7BP 2.02394729844446 2.21240501925011e-08 -0.407602262084023 0.176951318635 miRNATAP -0.29581894159429 7.87327121153188e-10 NA NA NA hsa-miR-200a-5p RGS7BP 2.19152245759943 3.17968183522514e-11 -0.407602262084023 0.176951318635 MirTarget -0.294801205134758 1.90770100765504e-08 NA NA NA hsa-miR-335-3p RGS7BP 2.29463721765513 4.1956113745077e-18 -0.407602262084023 0.176951318635 mirMAP -0.306151438520491 1.92844967116907e-06 NA NA NA hsa-miR-146b-5p RGS9 2.23105707690238 3.83997814011313e-23 -1.75386187658517 3.49809019235606e-09 miRanda -0.501820212939507 9.26445877363114e-12 NA NA NA hsa-miR-183-5p RHBDL3 2.08412478942637 1.08931431254487e-10 -0.700857885265183 0.00778905341346191 mirMAP -0.304985012080686 6.14471756353248e-11 NA NA NA hsa-miR-192-5p RHBDL3 2.0867723747501 3.57854249239079e-08 -0.700857885265183 0.00778905341346191 mirMAP -0.285405438769737 7.59488191908525e-13 NA NA NA hsa-miR-146b-5p RHOB 2.23105707690238 3.83997814011313e-23 -1.05159658010263 6.81750709839854e-07 miRanda -0.446306146128457 9.24183242256768e-19 NA NA NA hsa-miR-183-5p RHOB 2.08412478942637 1.08931431254487e-10 -1.05159658010263 6.81750709839854e-07 miRNATAP -0.39769017790503 2.02349421246284e-29 NA NA NA hsa-miR-21-5p RHOB 2.21515015440792 6.0468197386674e-49 -1.05159658010263 6.81750709839854e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.565290576123069 4.17921149096228e-16 21872591;25861727 miR 21 targets the tumor suppressor RhoB and regulates proliferation invasion and apoptosis in colorectal cancer cells; Here we show that expression of miR-21 in HEK293 and several colorectal cancer cells was found inversely correlated with ras homolog gene family member B RhoB expression; miR-21 expression significantly suppressed RhoB 3' UTR luciferase-reporter activity but the inhibitory effect was lost when the putative target sites were mutated; Exogenous miR-21 over-expression mimicked the effect of RhoB knockdown in promoting proliferation and invasion and inhibiting apoptosis whereas anti-miR-21 or RhoB expression yielded opposite effects in colorectal cancer cells; These results suggest that miR-21 is a regulator of RhoB expression and RhoB could be a useful target in exploring the potential therapeutic benefits of miR-21 mediated tumor cell behaviors in colorectal cancer;Here we demonstrate that intravenously-administered chlorotoxin CTX-coupled targeted stable nucleic acid lipid particle SNALP-formulated anti-miR-21 oligonucleotides accumulate preferentially within brain tumors and promote efficient miR-21 silencing which results in increased mRNA and protein levels of its target RhoB while showing no signs of systemic immunogenicity ; colorectal cancer;glioblastoma hsa-miR-141-5p RHOBTB2 2.13747696823946 1.73124674554872e-11 -0.167363449899785 0.19498650341299 mirMAP -0.10761990297901 4.41356364648823e-06 NA NA NA hsa-miR-146b-5p RHOBTB3 2.23105707690238 3.83997814011313e-23 0.116753499077459 0.613081108966582 MirTarget;miRanda -0.20424018184032 0.000351915867556703 NA NA NA hsa-miR-192-5p RHOBTB3 2.0867723747501 3.57854249239079e-08 0.116753499077459 0.613081108966582 miRNAWalker2_validate -0.194985894264289 3.46829160374809e-08 NA NA NA hsa-miR-21-5p RHOQ 2.21515015440792 6.0468197386674e-49 -0.181509167275028 0.112005666549592 miRNAWalker2_validate -0.158846177299076 3.32012120234618e-05 NA NA NA hsa-miR-335-3p RHOQ 2.29463721765513 4.1956113745077e-18 -0.181509167275028 0.112005666549592 mirMAP -0.156727579382447 4.25578465631197e-11 NA NA NA hsa-miR-146b-3p RIC3 2.08650140817622 5.3293570720033e-22 -2.21082418016103 4.10953188271034e-08 MirTarget -0.588385884400338 2.49504885335312e-08 NA NA NA hsa-miR-146b-5p RIC3 2.23105707690238 3.83997814011313e-23 -2.21082418016103 4.10953188271034e-08 miRanda -0.617996144245628 7.13127245129977e-10 NA NA NA hsa-miR-18a-5p RIC3 2.04701000113742 1.30593450319289e-12 -2.21082418016103 4.10953188271034e-08 MirTarget -0.675573702477532 1.02379433403479e-17 NA NA NA hsa-miR-335-3p RIC3 2.29463721765513 4.1956113745077e-18 -2.21082418016103 4.10953188271034e-08 MirTarget;mirMAP -0.710837160649243 3.44692460657047e-17 NA NA NA hsa-miR-146b-3p RILP 2.08650140817622 5.3293570720033e-22 -0.944508465417313 1.89628132821564e-08 miRNATAP -0.101334696832041 0.0245867175812861 NA NA NA hsa-miR-183-5p RIMBP2 2.08412478942637 1.08931431254487e-10 -1.96843867427001 4.61013756403965e-05 MirTarget;miRNATAP -0.351146120405002 7.3654165436632e-05 NA NA NA hsa-miR-200a-3p RIMBP2 2.02394729844446 2.21240501925011e-08 -1.96843867427001 4.61013756403965e-05 mirMAP -0.327647914787456 3.90735929030483e-05 NA NA NA hsa-miR-335-3p RIMBP2 2.29463721765513 4.1956113745077e-18 -1.96843867427001 4.61013756403965e-05 mirMAP -0.304577582762209 0.00400086914526418 NA NA NA hsa-miR-141-5p RIMKLB 2.13747696823946 1.73124674554872e-11 -0.516647470958743 0.0376812451743227 MirTarget -0.361055833179143 8.89555359706324e-17 NA NA NA hsa-miR-200a-5p RIMKLB 2.19152245759943 3.17968183522514e-11 -0.516647470958743 0.0376812451743227 MirTarget -0.348586537169034 7.34758826572071e-17 NA NA NA hsa-miR-200b-3p RIMKLB 2.06025765178663 3.07718049337497e-10 -0.516647470958743 0.0376812451743227 MirTarget;TargetScan -0.366519023218365 3.08828017106888e-18 NA NA NA hsa-miR-335-3p RIMKLB 2.29463721765513 4.1956113745077e-18 -0.516647470958743 0.0376812451743227 MirTarget -0.357624901965931 5.26395612687859e-12 NA NA NA hsa-miR-146b-3p RIMS1 2.08650140817622 5.3293570720033e-22 -3.14265555640351 5.605703571714e-09 PITA;miRNATAP -0.974295033207026 2.83660195046693e-12 NA NA NA hsa-miR-146b-5p RIMS1 2.23105707690238 3.83997814011313e-23 -3.14265555640351 5.605703571714e-09 miRanda -1.06515034422932 4.87794143090855e-16 NA NA NA hsa-miR-200a-3p RIMS1 2.02394729844446 2.21240501925011e-08 -3.14265555640351 5.605703571714e-09 MirTarget -0.571267894307089 9.76364491289439e-11 NA NA NA hsa-miR-135b-5p RIMS2 2.80066701698235 2.12546333413447e-11 -1.36522903123664 0.00207602001734613 MirTarget -0.415383509589258 5.89058004579074e-11 NA NA NA hsa-miR-146b-5p RIMS2 2.23105707690238 3.83997814011313e-23 -1.36522903123664 0.00207602001734613 mirMAP;miRNATAP -0.612653672874259 1.82765321006684e-08 NA NA NA hsa-miR-18a-5p RIMS2 2.04701000113742 1.30593450319289e-12 -1.36522903123664 0.00207602001734613 MirTarget -0.481608308229248 5.42720815044213e-08 NA NA NA hsa-miR-200b-3p RIMS2 2.06025765178663 3.07718049337497e-10 -1.36522903123664 0.00207602001734613 MirTarget;TargetScan -0.57810708470783 5.29128162742176e-14 NA NA NA hsa-miR-335-3p RIMS2 2.29463721765513 4.1956113745077e-18 -1.36522903123664 0.00207602001734613 mirMAP -0.459298703147461 1.37283594037839e-06 NA NA NA hsa-miR-183-5p RIMS3 2.08412478942637 1.08931431254487e-10 -1.3046164844765 2.73366807369862e-06 mirMAP -0.398801019310243 3.34012142148843e-16 NA NA NA hsa-miR-200a-3p RIMS3 2.02394729844446 2.21240501925011e-08 -1.3046164844765 2.73366807369862e-06 mirMAP -0.379761136186414 3.23613308028869e-18 NA NA NA hsa-miR-200b-3p RIMS3 2.06025765178663 3.07718049337497e-10 -1.3046164844765 2.73366807369862e-06 TargetScan -0.417630904651072 2.75647444951043e-18 NA NA NA hsa-miR-335-3p RIMS3 2.29463721765513 4.1956113745077e-18 -1.3046164844765 2.73366807369862e-06 mirMAP -0.375848255095713 2.5136544258967e-10 NA NA NA hsa-miR-18a-5p RIMS4 2.04701000113742 1.30593450319289e-12 -2.70405149113249 6.80814480144778e-07 mirMAP -0.638565507325469 6.253458846619e-09 NA NA NA hsa-miR-146b-5p RND2 2.23105707690238 3.83997814011313e-23 -1.8178228508284 1.00973380137171e-07 mirMAP;miRNATAP -0.68747287989525 6.95619510369123e-17 NA NA NA hsa-miR-92a-1-5p RND2 2.04820501765632 9.32117486799495e-13 -1.8178228508284 1.00973380137171e-07 MirTarget -0.503959420984304 4.63421039749578e-13 NA NA NA hsa-miR-21-5p RNF103 2.21515015440792 6.0468197386674e-49 -0.340621656163067 9.00028698777616e-06 MirTarget -0.122192765034415 2.25021667054147e-06 NA NA NA hsa-miR-146b-5p RNF11 2.23105707690238 3.83997814011313e-23 -0.739445158915551 3.42257608103258e-15 miRanda -0.191612922092137 1.67655760073051e-16 NA NA NA hsa-miR-200a-3p RNF11 2.02394729844446 2.21240501925011e-08 -0.739445158915551 3.42257608103258e-15 miRNATAP -0.133162042245036 1.63595432811029e-18 NA NA NA hsa-miR-200b-3p RNF11 2.06025765178663 3.07718049337497e-10 -0.739445158915551 3.42257608103258e-15 TargetScan -0.143407154989315 8.89340074425969e-18 NA NA NA hsa-miR-21-5p RNF11 2.21515015440792 6.0468197386674e-49 -0.739445158915551 3.42257608103258e-15 miRNAWalker2_validate -0.259757279535172 2.45270849985509e-16 NA NA NA hsa-miR-335-3p RNF11 2.29463721765513 4.1956113745077e-18 -0.739445158915551 3.42257608103258e-15 mirMAP -0.162471770488379 9.10066240812681e-16 NA NA NA hsa-miR-335-3p RNF112 2.29463721765513 4.1956113745077e-18 -1.79662386649869 1.55389359478445e-12 MirTarget -0.467600538864243 4.2499588863221e-18 NA NA NA hsa-miR-146b-5p RNF14 2.23105707690238 3.83997814011313e-23 -0.399368584924676 4.13152539227004e-07 miRanda -0.119485859646848 6.43151212615921e-10 NA NA NA hsa-miR-335-3p RNF144B 2.29463721765513 4.1956113745077e-18 -0.292369081593336 0.117661251051104 mirMAP -0.265863752562976 8.18697939808337e-12 NA NA NA hsa-miR-146b-5p RNF150 2.23105707690238 3.83997814011313e-23 -1.41142963779738 0.000190766781935343 miRanda -0.602710341753234 6.63642521565893e-11 NA NA NA hsa-miR-135b-5p RNF152 2.80066701698235 2.12546333413447e-11 -0.962532420630481 7.12697277401744e-07 MirTarget -0.162434263530842 1.07344651144899e-08 NA NA NA hsa-miR-335-3p RNF152 2.29463721765513 4.1956113745077e-18 -0.962532420630481 7.12697277401744e-07 mirMAP -0.217741511569254 2.22543302408447e-07 NA NA NA hsa-miR-141-5p RNF165 2.13747696823946 1.73124674554872e-11 -1.11992889821903 0.00120651282301094 mirMAP -0.599474212337054 2.67001430881127e-24 NA NA NA hsa-miR-335-3p RNF165 2.29463721765513 4.1956113745077e-18 -1.11992889821903 0.00120651282301094 MirTarget;mirMAP -0.426742056170049 6.54733616187666e-09 NA NA NA hsa-miR-335-3p RNF175 2.29463721765513 4.1956113745077e-18 0.382071226080982 0.0788909739531262 mirMAP -0.111216160933343 0.0181969974093954 NA NA NA hsa-miR-335-3p RNF180 2.29463721765513 4.1956113745077e-18 -1.12722954662506 6.48445023401222e-06 mirMAP -0.46890404537824 5.18788642166745e-20 NA NA NA hsa-miR-146b-5p RNF212 2.23105707690238 3.83997814011313e-23 -1.24090219365196 0.000305807372355562 miRanda -0.418973792490596 8.90195309195811e-07 NA NA NA hsa-miR-192-5p RNF217 2.0867723747501 3.57854249239079e-08 -1.00205335921036 2.29819486137061e-05 MirTarget -0.357568821443667 2.01381309399773e-25 NA NA NA hsa-miR-200a-3p RNF217 2.02394729844446 2.21240501925011e-08 -1.00205335921036 2.29819486137061e-05 mirMAP -0.377658573895907 5.42423858889138e-26 NA NA NA hsa-miR-200a-5p RNF217 2.19152245759943 3.17968183522514e-11 -1.00205335921036 2.29819486137061e-05 mirMAP -0.391998486299286 1.55380359600188e-23 NA NA NA hsa-miR-335-3p RNF217 2.29463721765513 4.1956113745077e-18 -1.00205335921036 2.29819486137061e-05 mirMAP -0.382137477684377 1.07061278439149e-14 NA NA NA hsa-miR-200a-3p RNF38 2.02394729844446 2.21240501925011e-08 -0.173471812012056 0.142869431269605 MirTarget;mirMAP -0.15913820630369 1.68216691456042e-18 NA NA NA hsa-miR-200b-3p RNF38 2.06025765178663 3.07718049337497e-10 -0.173471812012056 0.142869431269605 MirTarget;TargetScan -0.163894852040884 3.4644896189701e-16 NA NA NA hsa-miR-335-3p RNF38 2.29463721765513 4.1956113745077e-18 -0.173471812012056 0.142869431269605 mirMAP -0.108157756843642 1.79911613560852e-05 NA NA NA hsa-miR-146b-5p RNLS 2.23105707690238 3.83997814011313e-23 -1.61512614886855 1.12498941467524e-10 miRanda -0.317770150501552 6.12198873903609e-07 NA NA NA hsa-miR-18a-5p ROBO2 2.04701000113742 1.30593450319289e-12 0.0922258917601628 0.787683745010493 miRNATAP -0.147850365352305 0.0331733069376495 NA NA NA hsa-miR-192-5p ROGDI 2.0867723747501 3.57854249239079e-08 -1.12436032365551 2.83525909681017e-19 mirMAP -0.142735600103372 1.72694263248387e-12 NA NA NA hsa-miR-135b-5p ROR1 2.80066701698235 2.12546333413447e-11 -0.861512083100719 0.000181264380069288 miRNATAP -0.165376961886804 8.69984710757021e-07 NA NA NA hsa-miR-146b-5p ROR1 2.23105707690238 3.83997814011313e-23 -0.861512083100719 0.000181264380069288 miRanda;miRNATAP -0.358166510936253 1.88078674631315e-10 NA NA NA hsa-miR-21-5p ROR1 2.21515015440792 6.0468197386674e-49 -0.861512083100719 0.000181264380069288 miRNATAP -0.428281306285256 3.00866820522913e-08 NA NA NA hsa-miR-335-3p ROR1 2.29463721765513 4.1956113745077e-18 -0.861512083100719 0.000181264380069288 mirMAP -0.267727502553725 5.4091304357777e-08 NA NA NA hsa-miR-183-5p RORA 2.08412478942637 1.08931431254487e-10 -0.888667376601635 4.99889595160793e-06 miRNATAP -0.298811280173056 8.90831988539926e-19 NA NA NA hsa-miR-18a-5p RORA 2.04701000113742 1.30593450319289e-12 -0.888667376601635 4.99889595160793e-06 MirTarget;miRNATAP -0.349378821867542 5.85677598425048e-21 NA NA NA hsa-miR-200a-3p RORA 2.02394729844446 2.21240501925011e-08 -0.888667376601635 4.99889595160793e-06 MirTarget;miRNATAP -0.265486863281319 2.97405668978742e-18 NA NA NA hsa-miR-200a-5p RORA 2.19152245759943 3.17968183522514e-11 -0.888667376601635 4.99889595160793e-06 MirTarget;miRNATAP -0.281532642267564 1.96107724855766e-17 NA NA NA hsa-miR-335-3p RORA 2.29463721765513 4.1956113745077e-18 -0.888667376601635 4.99889595160793e-06 MirTarget -0.319178238234929 4.28468000669057e-15 NA NA NA hsa-miR-935 RORA 2.321600496365 1.00042201726114e-07 -0.888667376601635 4.99889595160793e-06 MirTarget;miRNATAP -0.172785465424923 4.52874073229985e-10 NA NA NA hsa-miR-200b-3p RPS6KA2 2.06025765178663 3.07718049337497e-10 -0.569696503739038 0.00012691212615164 TargetScan -0.183081097691008 1.82222094894106e-12 NA NA NA hsa-miR-18a-5p RPS6KA5 2.04701000113742 1.30593450319289e-12 -1.01087120168767 5.97916652298015e-12 MirTarget -0.219401419265854 1.2886139895923e-13 NA NA NA hsa-miR-335-3p RPS6KA5 2.29463721765513 4.1956113745077e-18 -1.01087120168767 5.97916652298015e-12 mirMAP -0.178084396603656 3.67690502808319e-08 NA NA NA hsa-miR-200a-3p RPS6KA6 2.02394729844446 2.21240501925011e-08 -2.98891177318268 6.67782798681791e-14 MirTarget -0.444697852564563 2.20547405530152e-11 NA NA NA hsa-miR-335-3p RPS6KA6 2.29463721765513 4.1956113745077e-18 -2.98891177318268 6.67782798681791e-14 MirTarget -0.673509005387343 5.84871268463392e-15 NA NA NA hsa-miR-146b-5p RRAGA 2.23105707690238 3.83997814011313e-23 -0.590833723706647 9.82044904383956e-10 miRanda -0.162806740055363 8.89519318196327e-12 NA NA NA hsa-miR-335-3p RRAGD 2.29463721765513 4.1956113745077e-18 -0.254157932024554 0.27375739473249 mirMAP -0.148750703054207 0.00296479878614463 NA NA NA hsa-miR-335-3p RSAD2 2.29463721765513 4.1956113745077e-18 -0.0997826238610049 0.699740246305903 mirMAP -0.14009861325708 0.0121523634942188 NA NA NA hsa-miR-196a-5p RSPO2 5.05945965885472 4.48343841468539e-25 -3.03817748898105 5.11795530924469e-10 MirTarget;miRNATAP -0.422159248663706 3.14107883826427e-14 NA NA NA hsa-miR-196b-5p RSPO2 4.51951031652328 7.04026169031626e-18 -3.03817748898105 5.11795530924469e-10 MirTarget;miRNATAP -0.436724274661667 3.51631292921478e-17 NA NA NA hsa-miR-200a-3p RSPO2 2.02394729844446 2.21240501925011e-08 -3.03817748898105 5.11795530924469e-10 MirTarget -0.686366003344496 1.08199526522944e-18 NA NA NA hsa-miR-146b-5p RSPO3 2.23105707690238 3.83997814011313e-23 -0.413092961972705 0.273194842658858 miRanda -0.246685669654665 0.00868398107551269 NA NA NA hsa-miR-335-3p RSU1 2.29463721765513 4.1956113745077e-18 -0.32824544052134 0.000365053611009083 mirMAP -0.120234444541686 5.54067007923866e-10 NA NA NA hsa-miR-183-5p RTN4 2.08412478942637 1.08931431254487e-10 -0.411549538148011 0.000141083434427497 miRNAWalker2_validate -0.146520538083903 8.33727478172824e-15 NA NA NA hsa-miR-21-5p RTN4 2.21515015440792 6.0468197386674e-49 -0.411549538148011 0.000141083434427497 miRNAWalker2_validate;miRTarBase -0.161265147044833 1.02187754265933e-05 NA NA NA hsa-miR-141-5p RTN4RL1 2.13747696823946 1.73124674554872e-11 -0.63538052092998 0.11448562102048 MirTarget -0.216686682888246 0.00353578549780588 NA NA NA hsa-miR-192-5p RUFY3 2.0867723747501 3.57854249239079e-08 -0.289478272206307 0.00359568710719357 miRNAWalker2_validate -0.125581649670283 1.06502779180138e-17 NA NA NA hsa-miR-146b-5p RUNDC3A 2.23105707690238 3.83997814011313e-23 -1.59386807427387 1.1988021151005e-05 miRanda -0.608336566172614 7.91388905343403e-12 NA NA NA hsa-miR-146b-5p RUNDC3B 2.23105707690238 3.83997814011313e-23 -1.01699292837566 1.21190372674825e-05 miRanda -0.202655507430189 0.000545069704776852 NA NA NA hsa-miR-146b-3p RUNX1T1 2.08650140817622 5.3293570720033e-22 -0.344000642439472 0.237404358600589 miRNATAP -0.212255901972885 0.00514164943009769 NA NA NA hsa-miR-146b-5p RUNX1T1 2.23105707690238 3.83997814011313e-23 -0.344000642439472 0.237404358600589 PITA;miRanda;miRNATAP -0.283223103066414 8.36460953227769e-05 NA NA NA hsa-miR-183-5p RUNX1T1 2.08412478942637 1.08931431254487e-10 -0.344000642439472 0.237404358600589 miRNATAP -0.563772791045631 1.95864436316825e-33 NA NA NA hsa-miR-200b-3p RUNX1T1 2.06025765178663 3.07718049337497e-10 -0.344000642439472 0.237404358600589 TargetScan -0.498780478272802 1.44553040827209e-25 NA NA NA hsa-miR-335-3p RUNX1T1 2.29463721765513 4.1956113745077e-18 -0.344000642439472 0.237404358600589 mirMAP -0.368536279812623 1.73611915844477e-09 NA NA NA hsa-miR-200b-3p RUSC2 2.06025765178663 3.07718049337497e-10 -0.140088157149797 0.375609388037744 TargetScan -0.277382036667665 3.37739602544384e-27 NA NA NA hsa-miR-146b-3p RXRG 2.08650140817622 5.3293570720033e-22 -3.72352052908439 1.86176380601591e-17 MirTarget -0.853335469912944 2.76305426402309e-13 NA NA NA hsa-miR-141-5p RYR2 2.13747696823946 1.73124674554872e-11 -1.46628449007373 0.000305672939640461 miRNATAP -0.663859227639265 3.40709964226306e-21 NA NA NA hsa-miR-335-3p RYR2 2.29463721765513 4.1956113745077e-18 -1.46628449007373 0.000305672939640461 MirTarget -0.521636716093955 1.5231168458344e-09 NA NA NA hsa-miR-146b-5p S100A1 2.23105707690238 3.83997814011313e-23 -1.26683658653878 5.38947588260372e-06 miRanda -0.350819904211982 4.40651095838113e-07 NA NA NA hsa-miR-146b-5p S1PR3 2.23105707690238 3.83997814011313e-23 -0.222065396904603 0.39239061983226 miRanda -0.315741815355937 6.88703177104084e-07 NA NA NA hsa-miR-335-3p S1PR3 2.29463721765513 4.1956113745077e-18 -0.222065396904603 0.39239061983226 mirMAP -0.382985049508936 1.10664449666451e-12 NA NA NA hsa-miR-183-5p SACS 2.08412478942637 1.08931431254487e-10 0.342780111245514 0.116894496849562 MirTarget;miRNATAP -0.190656613077032 1.16333795183546e-06 NA NA NA hsa-miR-146b-5p SALL2 2.23105707690238 3.83997814011313e-23 -1.39815836054303 2.28427329386325e-05 miRanda -0.599859120286159 5.71712162437843e-14 NA NA NA hsa-miR-141-5p SAMD4A 2.13747696823946 1.73124674554872e-11 -0.132799293939158 0.555317186016636 mirMAP -0.423948620825463 2.629998284463e-30 NA NA NA hsa-miR-183-5p SAMD4A 2.08412478942637 1.08931431254487e-10 -0.132799293939158 0.555317186016636 MirTarget;miRNATAP -0.406342426266279 3.18342515024667e-28 NA NA NA hsa-miR-192-5p SAMD4A 2.0867723747501 3.57854249239079e-08 -0.132799293939158 0.555317186016636 MirTarget -0.281737548156516 2.01373724111035e-17 NA NA NA hsa-miR-194-5p SAMD4A 2.24386881692218 9.35116329002209e-11 -0.132799293939158 0.555317186016636 miRNATAP -0.267978529774403 2.11911826936174e-13 NA NA NA hsa-miR-200a-3p SAMD4A 2.02394729844446 2.21240501925011e-08 -0.132799293939158 0.555317186016636 miRNATAP -0.369376785352518 7.00822720968804e-29 NA NA NA hsa-miR-194-5p SAMD8 2.24386881692218 9.35116329002209e-11 -0.111723785588263 0.403689943508281 MirTarget -0.108045381806358 1.21300258503109e-06 NA NA NA hsa-miR-141-5p SAMHD1 2.13747696823946 1.73124674554872e-11 0.0720854590839357 0.628948617894497 mirMAP -0.10769073461381 7.56547145499759e-05 NA NA NA hsa-miR-21-5p SAR1B 2.21515015440792 6.0468197386674e-49 -0.774235041903762 3.57883769379402e-14 mirMAP -0.131522080496085 0.000274125706530098 NA NA NA hsa-miR-135b-5p SARM1 2.80066701698235 2.12546333413447e-11 -0.515539220220322 0.000237694974843706 mirMAP -0.11035781746891 5.76300406558795e-08 NA NA NA hsa-miR-92a-1-5p SARM1 2.04820501765632 9.32117486799495e-13 -0.515539220220322 0.000237694974843706 mirMAP -0.10608532901442 0.000278649895088887 NA NA NA hsa-miR-200b-3p SASH1 2.06025765178663 3.07718049337497e-10 -0.502378415947332 0.00175474680872799 MirTarget -0.183694829341626 6.51081898599384e-11 NA NA NA hsa-miR-21-5p SASH1 2.21515015440792 6.0468197386674e-49 -0.502378415947332 0.00175474680872799 miRNAWalker2_validate;MirTarget -0.275252945138833 3.23373732718039e-07 NA NA NA hsa-miR-335-3p SASH3 2.29463721765513 4.1956113745077e-18 -0.0207008808267095 0.935148943992375 mirMAP -0.147647875398673 0.00713385648133368 NA NA NA hsa-miR-146b-5p SATB1 2.23105707690238 3.83997814011313e-23 -0.899906881771092 2.24598761295463e-05 miRanda -0.329686749166414 2.42840810916177e-10 NA NA NA hsa-miR-18a-5p SATB1 2.04701000113742 1.30593450319289e-12 -0.899906881771092 2.24598761295463e-05 miRNATAP -0.282736278540598 1.84916457743213e-11 NA NA NA hsa-miR-194-5p SATB1 2.24386881692218 9.35116329002209e-11 -0.899906881771092 2.24598761295463e-05 miRNATAP -0.259375584713902 1.16200351699883e-13 NA NA NA hsa-miR-21-5p SATB1 2.21515015440792 6.0468197386674e-49 -0.899906881771092 2.24598761295463e-05 MirTarget;miRNATAP -0.496118098340602 1.69791879632753e-12 27107063 SATB1 is Down regulated in Clear Cell Renal Cell Carcinoma and Correlates with miR 21 5p Overexpression and Poor Prognosis; This study aimed to determine the expression levels of SATB1 as well as miR-21-5p -the post-transcriptional repressor of SATB1 expression- in clear cell renal cell carcinoma ccRCC and to investigate their association with the progression of ccRCC; Immunohistochemistry and quantitative polymerase chain reaction were used to assess the expression of SATB1 protein and mRNA as well as miR-21-5p in tumor and matched normal kidney tissues collected from 56 ccRCC patients; SATB1 mRNA level was down-regulated in ccRCC tissue and inversely correlated with the content of miR-21-5p; Down-regulation of SATB1 mRNA and up-regulation of miR-21-5p were associated with shorter patient survival; Decreased expression of SATB1 in ccRCC may result from over-expressed miR-21-5p worse prognosis;progression;poor survival kidney renal cell cancer hsa-miR-335-3p SATB1 2.29463721765513 4.1956113745077e-18 -0.899906881771092 2.24598761295463e-05 MirTarget -0.26713210581082 3.90381221991884e-09 NA NA NA hsa-miR-1-3p SATB2 -2.73171785118192 3.4424534921136e-12 1.3305053528686 1.03030765028331e-07 MirTarget -0.183715581070836 9.74491720121604e-07 NA NA NA hsa-miR-146b-5p SBDSP1 2.23105707690238 3.83997814011313e-23 -0.112780474777289 0.30585881756557 miRanda -0.1553526960627 5.36432779562574e-09 NA NA NA hsa-miR-146b-5p SBF2 2.23105707690238 3.83997814011313e-23 -0.172545252490292 0.122262359141616 miRNATAP -0.133258729641621 1.0403547155335e-06 NA NA NA hsa-miR-146b-5p SBSPON 2.23105707690238 3.83997814011313e-23 -1.82449074362515 5.14488465520048e-07 miRNATAP -0.676936635813981 1.75508920075362e-14 NA NA NA hsa-miR-200b-3p SBSPON 2.06025765178663 3.07718049337497e-10 -1.82449074362515 5.14488465520048e-07 MirTarget;TargetScan -0.48490473573115 3.02227370466804e-14 NA NA NA hsa-miR-335-3p SBSPON 2.29463721765513 4.1956113745077e-18 -1.82449074362515 5.14488465520048e-07 MirTarget -0.599612385045241 3.98069590526168e-15 NA NA NA hsa-miR-335-3p SCGB3A1 2.29463721765513 4.1956113745077e-18 -1.66609870472544 0.000628321648921988 mirMAP -0.270568789384161 0.0110209467259319 NA NA NA hsa-miR-146b-5p SCIN 2.23105707690238 3.83997814011313e-23 -2.21669196338779 2.68714851206979e-10 miRanda -0.395195536896554 1.04371756036697e-05 NA NA NA hsa-miR-192-5p SCMH1 2.0867723747501 3.57854249239079e-08 -0.43649737377921 0.00104525100356383 miRNAWalker2_validate -0.152157520902981 2.9742996207332e-14 NA NA NA hsa-miR-21-5p SCML2 2.21515015440792 6.0468197386674e-49 0.218188238977812 0.530973025458845 MirTarget;miRNATAP -0.240437361879458 0.0424586616342264 NA NA NA hsa-miR-196a-5p SCN11A 5.05945965885472 4.48343841468539e-25 -1.14952987855662 0.00299169454930274 miRNAWalker2_validate -0.198519305086489 7.62685431522637e-06 NA NA NA hsa-miR-135b-5p SCN2A 2.80066701698235 2.12546333413447e-11 0.317164447705599 0.477497388671926 MirTarget -0.148465890672528 0.0237157964137174 NA NA NA hsa-miR-200b-3p SCN2A 2.06025765178663 3.07718049337497e-10 0.317164447705599 0.477497388671926 MirTarget;TargetScan -0.302181872769901 0.00015262490405479 NA NA NA hsa-miR-200a-3p SCN2B 2.02394729844446 2.21240501925011e-08 -2.22237853128849 2.58947336008345e-06 MirTarget;miRNATAP -0.793987378096715 5.10992757473391e-29 NA NA NA hsa-miR-92a-1-5p SCN2B 2.04820501765632 9.32117486799495e-13 -2.22237853128849 2.58947336008345e-06 mirMAP -0.831007777780073 6.99464443682965e-19 NA NA NA hsa-miR-183-5p SCN3A 2.08412478942637 1.08931431254487e-10 -1.5009210460306 8.66949811687225e-07 miRNATAP -0.336636131063231 1.06390471883965e-09 NA NA NA hsa-miR-192-5p SCN3A 2.0867723747501 3.57854249239079e-08 -1.5009210460306 8.66949811687225e-07 MirTarget -0.179104674487915 0.000225802878390479 NA NA NA hsa-miR-200b-3p SCN3A 2.06025765178663 3.07718049337497e-10 -1.5009210460306 8.66949811687225e-07 mirMAP -0.234168086480791 2.49259137542068e-05 NA NA NA hsa-miR-146b-5p SCN3B 2.23105707690238 3.83997814011313e-23 -1.12424455507364 0.000589168065844479 MirTarget;PITA;miRanda;miRNATAP -0.557032051716441 1.96130397565108e-12 NA NA NA hsa-miR-200b-3p SCN3B 2.06025765178663 3.07718049337497e-10 -1.12424455507364 0.000589168065844479 TargetScan -0.456910237126413 4.94035125738474e-16 NA NA NA hsa-miR-335-3p SCN3B 2.29463721765513 4.1956113745077e-18 -1.12424455507364 0.000589168065844479 mirMAP -0.391790194352312 1.96351490100745e-08 NA NA NA hsa-miR-935 SCN3B 2.321600496365 1.00042201726114e-07 -1.12424455507364 0.000589168065844479 mirMAP -0.337557770102386 1.26156812715869e-13 NA NA NA hsa-miR-200a-3p SCN4A 2.02394729844446 2.21240501925011e-08 -0.368249844121816 0.293155501396057 mirMAP -0.242994651202008 1.91155692497627e-05 NA NA NA hsa-miR-146b-5p SCN5A 2.23105707690238 3.83997814011313e-23 -0.259448692335781 0.48224277680017 miRanda -0.496715464639109 3.38168229260124e-08 NA NA NA hsa-miR-200b-3p SCN5A 2.06025765178663 3.07718049337497e-10 -0.259448692335781 0.48224277680017 TargetScan -0.289726916033095 1.02081984009576e-05 NA NA NA hsa-miR-146b-5p SCOC 2.23105707690238 3.83997814011313e-23 -0.590110862394432 2.53745141468561e-05 miRanda -0.128101413322491 0.000269544171132039 NA NA NA hsa-miR-146b-3p SCRN1 2.08650140817622 5.3293570720033e-22 -0.00151151687256945 0.995131134492659 MirTarget -0.232757758338166 0.000282447107845164 NA NA NA hsa-miR-192-5p SCRN1 2.0867723747501 3.57854249239079e-08 -0.00151151687256945 0.995131134492659 mirMAP -0.217958963296022 8.280243495838e-09 NA NA NA hsa-miR-21-5p SCRN1 2.21515015440792 6.0468197386674e-49 -0.00151151687256945 0.995131134492659 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.174031609110733 0.0387270087024981 NA NA NA hsa-miR-335-3p SCRN3 2.29463721765513 4.1956113745077e-18 -0.361689460444137 0.00047623878432956 mirMAP -0.115954352264792 1.42605258177434e-07 NA NA NA hsa-miR-146b-5p SCUBE2 2.23105707690238 3.83997814011313e-23 -2.170596660456 3.52055804528954e-12 miRanda -0.666773751350223 2.13933286254983e-18 NA NA NA hsa-miR-200a-3p SCUBE2 2.02394729844446 2.21240501925011e-08 -2.170596660456 3.52055804528954e-12 MirTarget -0.453393396612592 9.58837501217415e-20 NA NA NA hsa-miR-335-3p SCUBE2 2.29463721765513 4.1956113745077e-18 -2.170596660456 3.52055804528954e-12 mirMAP -0.549287835144807 1.56968042890908e-16 NA NA NA hsa-miR-200b-3p SCUBE3 2.06025765178663 3.07718049337497e-10 0.0624568857731003 0.800297924546723 mirMAP -0.222409960990608 3.35656643018352e-07 NA NA NA hsa-miR-200a-3p SDC2 2.02394729844446 2.21240501925011e-08 -0.361794289426367 0.0421687423135213 MirTarget -0.266628331171074 3.39136918313894e-23 NA NA NA hsa-miR-200b-3p SDC2 2.06025765178663 3.07718049337497e-10 -0.361794289426367 0.0421687423135213 TargetScan -0.293280882513722 2.65649850544273e-23 NA NA NA hsa-miR-335-3p SDC2 2.29463721765513 4.1956113745077e-18 -0.361794289426367 0.0421687423135213 MirTarget;mirMAP -0.235294315347381 3.01421680701244e-10 NA NA NA hsa-miR-192-5p SDC3 2.0867723747501 3.57854249239079e-08 0.0412816778750296 0.815551299654887 mirMAP -0.171796202818988 1.44359566350892e-10 NA NA NA hsa-miR-183-5p SDK1 2.08412478942637 1.08931431254487e-10 -0.0786714772374784 0.764582199774333 mirMAP -0.101571347031729 0.0339547527662567 NA NA NA hsa-miR-135b-5p SDK2 2.80066701698235 2.12546333413447e-11 -0.581686295778627 0.0604550673556843 mirMAP -0.114008259994264 0.0124387214934122 NA NA NA hsa-miR-141-5p SDK2 2.13747696823946 1.73124674554872e-11 -0.581686295778627 0.0604550673556843 mirMAP -0.137506949749606 0.016524380516723 NA NA NA hsa-miR-200a-3p SDK2 2.02394729844446 2.21240501925011e-08 -0.581686295778627 0.0604550673556843 mirMAP -0.100733932853605 0.0485563314350183 NA NA NA hsa-miR-200b-3p SDK2 2.06025765178663 3.07718049337497e-10 -0.581686295778627 0.0604550673556843 TargetScan -0.128843433487224 0.0213740112033626 NA NA NA hsa-miR-92a-1-5p SDK2 2.04820501765632 9.32117486799495e-13 -0.581686295778627 0.0604550673556843 mirMAP -0.156963567891125 0.014938578554075 NA NA NA hsa-miR-335-3p SDPR 2.29463721765513 4.1956113745077e-18 -1.66120982970094 2.21547791707255e-08 MirTarget -0.536967229048397 4.40928180395255e-18 NA NA NA hsa-miR-335-3p SDR42E1 2.29463721765513 4.1956113745077e-18 -1.1714141513343 0.00142868884414 MirTarget;mirMAP -0.161326135487912 0.0445111043691481 NA NA NA hsa-miR-21-5p SEC14L5 2.21515015440792 6.0468197386674e-49 -2.00691526440237 3.58158652448988e-07 mirMAP -0.965307447174894 1.83296399763188e-13 NA NA NA hsa-miR-335-3p SEC14L5 2.29463721765513 4.1956113745077e-18 -2.00691526440237 3.58158652448988e-07 mirMAP -0.376194940394907 1.2850875013112e-05 NA NA NA hsa-miR-935 SEC14L5 2.321600496365 1.00042201726114e-07 -2.00691526440237 3.58158652448988e-07 mirMAP -0.22119604717659 0.000128670611703456 NA NA NA hsa-miR-21-5p SEC22C 2.21515015440792 6.0468197386674e-49 -0.452678492555002 4.53707163763124e-08 mirMAP -0.14807193752645 1.30045506807807e-07 NA NA NA hsa-miR-200b-3p SEC23A 2.06025765178663 3.07718049337497e-10 -0.428530407481632 0.000517364444097623 MirTarget;TargetScan -0.20657309547581 6.99921830187599e-24 NA NA NA hsa-miR-200a-3p SECISBP2L 2.02394729844446 2.21240501925011e-08 -0.57031166178403 4.09953159416214e-08 MirTarget -0.138543556423957 3.0547313973473e-17 NA NA NA hsa-miR-200b-3p SECISBP2L 2.06025765178663 3.07718049337497e-10 -0.57031166178403 4.09953159416214e-08 TargetScan -0.14712915810987 4.26992791693372e-16 NA NA NA hsa-miR-335-3p SECISBP2L 2.29463721765513 4.1956113745077e-18 -0.57031166178403 4.09953159416214e-08 MirTarget -0.175096990028383 8.13471068209847e-16 NA NA NA hsa-miR-141-5p SELE 2.13747696823946 1.73124674554872e-11 0.662517529432636 0.0508837473525687 MirTarget -0.239103441540336 0.000124634816966706 NA NA NA hsa-miR-135b-5p SEMA3A 2.80066701698235 2.12546333413447e-11 -0.179919346499373 0.561052089127856 MirTarget -0.205121816378986 4.69156720304326e-06 NA NA NA hsa-miR-335-3p SEMA3A 2.29463721765513 4.1956113745077e-18 -0.179919346499373 0.561052089127856 MirTarget -0.207265341819534 0.00187428670329023 NA NA NA hsa-miR-141-5p SEMA3C 2.13747696823946 1.73124674554872e-11 -0.271505446712989 0.311526253264012 MirTarget -0.365441938611273 8.42343203640558e-15 NA NA NA hsa-miR-335-3p SEMA3C 2.29463721765513 4.1956113745077e-18 -0.271505446712989 0.311526253264012 MirTarget;mirMAP -0.168882342503214 0.00351409281430738 NA NA NA hsa-miR-335-3p SEMA3D 2.29463721765513 4.1956113745077e-18 -1.73377572221593 1.94522521277914e-05 MirTarget -0.435060271193207 6.99311883189067e-07 NA NA NA hsa-miR-200a-5p SEMA3E 2.19152245759943 3.17968183522514e-11 -1.71693139935495 0.00137029181332969 MirTarget -0.524242216369564 2.48035422335133e-08 NA NA NA hsa-miR-146b-5p SEMA3G 2.23105707690238 3.83997814011313e-23 -0.432881767688599 0.0275397587964678 miRNATAP -0.169576095947947 0.000516649129468077 NA NA NA hsa-miR-335-3p SEMA3G 2.29463721765513 4.1956113745077e-18 -0.432881767688599 0.0275397587964678 mirMAP -0.227341922722369 4.76480957749982e-08 NA NA NA hsa-miR-335-3p SEMA4A 2.29463721765513 4.1956113745077e-18 -0.788353954742469 0.000263147303905448 MirTarget -0.148382176332914 0.001611501614563 NA NA NA hsa-miR-146b-3p SEMA4C 2.08650140817622 5.3293570720033e-22 0.0997965897725477 0.505275274064598 MirTarget -0.148168983345572 0.000126291995725623 NA NA NA hsa-miR-200a-3p SEMA6A 2.02394729844446 2.21240501925011e-08 -0.78947725978746 0.0133684925524848 MirTarget;miRNATAP -0.267506831230683 2.17449849954676e-07 NA NA NA hsa-miR-183-5p SEMA6D 2.08412478942637 1.08931431254487e-10 -1.55565558119296 1.29394597397564e-07 miRNATAP -0.349353848044944 5.09000667413315e-11 NA NA NA hsa-miR-200b-3p SEMA6D 2.06025765178663 3.07718049337497e-10 -1.55565558119296 1.29394597397564e-07 TargetScan -0.281805749940666 1.25498679278817e-07 NA NA NA hsa-miR-335-3p SEMA6D 2.29463721765513 4.1956113745077e-18 -1.55565558119296 1.29394597397564e-07 mirMAP -0.255497076611072 7.94215456538861e-05 NA NA NA hsa-miR-133a-3p SEMG2 -2.63342156915404 5.72661351480585e-12 0.969493684488499 0.14413426695436 MirTarget -0.267624165573707 0.00856276940007052 NA NA NA hsa-miR-192-5p SEPT10 2.0867723747501 3.57854249239079e-08 -0.29436849945031 0.0169826283606985 miRNAWalker2_validate -0.143561757199142 5.83373079076226e-15 NA NA NA hsa-miR-200a-3p SEPT6 2.02394729844446 2.21240501925011e-08 -0.597683819994722 0.00181267956045348 mirMAP -0.256019721798803 7.12241577157189e-18 NA NA NA hsa-miR-935 SEPT6 2.321600496365 1.00042201726114e-07 -0.597683819994722 0.00181267956045348 miRNATAP -0.158546417204416 4.96504764682608e-09 NA NA NA hsa-miR-183-5p SEPT7 2.08412478942637 1.08931431254487e-10 0.0277761378075443 0.749990388336138 miRNATAP -0.104849077745573 4.20353561542168e-12 NA NA NA hsa-miR-200a-3p SEPT7 2.02394729844446 2.21240501925011e-08 0.0277761378075443 0.749990388336138 miRNAWalker2_validate;MirTarget;miRNATAP -0.124476266869426 2.19101554132703e-21 NA NA NA hsa-miR-200a-5p SEPT7 2.19152245759943 3.17968183522514e-11 0.0277761378075443 0.749990388336138 mirMAP -0.142989092782462 2.24334518234225e-24 NA NA NA hsa-miR-200b-3p SEPT7 2.06025765178663 3.07718049337497e-10 0.0277761378075443 0.749990388336138 miRNAWalker2_validate -0.129857380114629 3.84748058014405e-19 NA NA NA hsa-miR-146b-5p SERINC1 2.23105707690238 3.83997814011313e-23 -0.381876612143236 3.23474497421462e-05 miRanda -0.1506029713367 1.30481021557449e-11 NA NA NA hsa-miR-200b-3p SERINC1 2.06025765178663 3.07718049337497e-10 -0.381876612143236 3.23474497421462e-05 MirTarget;TargetScan -0.15147733842841 5.06226539143008e-23 NA NA NA hsa-miR-335-3p SERPINE2 2.29463721765513 4.1956113745077e-18 0.124636258296181 0.636118825227613 MirTarget -0.116686573405024 0.0406551915157968 NA NA NA hsa-miR-200b-3p SERPINI1 2.06025765178663 3.07718049337497e-10 -0.404315037266264 0.019875159578311 TargetScan -0.135558820730434 1.20381248680509e-05 NA NA NA hsa-miR-21-5p SERPINI1 2.21515015440792 6.0468197386674e-49 -0.404315037266264 0.019875159578311 miRNAWalker2_validate -0.188007539077205 0.00141707610411579 22464652 MicroRNA 21 inhibits Serpini1 a gene with novel tumour suppressive effects in gastric cancer; Molecular techniques include microRNA microarrays cDNA microarrays qRT-PCR for miR and mRNA expression transfection of MKN28 with miR-21 inhibitor or Serpini1 followed by Western blotting cell cycle analysis by flow cytometry and luciferase reporter assay; This search identified Serpini1 as a putative miR-21 target; Luciferase assays demonstrated direct interaction between miR-21 and Serpini1 3'UTR miR-21 and Serpini1 expression levels were inversely correlated in a subgroup of gastric cancers suggesting a regulatory mechanism that included both of these molecules; Taken together these data suggest that in a subgroup of gastric cancers miR-21 is upregulated inducing downregulation of Serpini1 which in turn releases the G1-S transition checkpoint with the end result being increased tumour growth gastric cancer hsa-miR-146b-3p SERTAD4 2.08650140817622 5.3293570720033e-22 -0.855300469182066 0.00851964081929357 MirTarget;PITA -0.570707417323762 3.38213581564251e-12 NA NA NA hsa-miR-183-5p SERTAD4 2.08412478942637 1.08931431254487e-10 -0.855300469182066 0.00851964081929357 miRNAWalker2_validate -0.509937530817699 3.4909589123251e-20 NA NA NA hsa-miR-192-5p SERTAD4 2.0867723747501 3.57854249239079e-08 -0.855300469182066 0.00851964081929357 miRNAWalker2_validate -0.389487054289046 1.08051364705783e-15 NA NA NA hsa-miR-335-3p SERTAD4 2.29463721765513 4.1956113745077e-18 -0.855300469182066 0.00851964081929357 mirMAP -0.497834064486878 1.75577785579287e-13 NA NA NA hsa-miR-335-3p SERTM1 2.29463721765513 4.1956113745077e-18 -5.41827572066109 3.57665863763747e-24 mirMAP -0.849831256213951 3.13060546541601e-12 NA NA NA hsa-miR-21-5p SESN1 2.21515015440792 6.0468197386674e-49 -0.316273897424733 0.0791103584277436 miRNAWalker2_validate -0.177386141100824 0.00369222639606522 NA NA NA hsa-miR-146b-5p SESN3 2.23105707690238 3.83997814011313e-23 -0.63123898051413 0.0145175326583435 PITA;miRanda;miRNATAP -0.2252117910017 0.000462915809264986 NA NA NA hsa-miR-200a-5p SESN3 2.19152245759943 3.17968183522514e-11 -0.63123898051413 0.0145175326583435 mirMAP -0.230123090397614 3.73282341124016e-07 NA NA NA hsa-miR-200b-3p SESN3 2.06025765178663 3.07718049337497e-10 -0.63123898051413 0.0145175326583435 MirTarget;TargetScan -0.224407240713081 1.04086423098693e-06 NA NA NA hsa-miR-335-3p SESN3 2.29463721765513 4.1956113745077e-18 -0.63123898051413 0.0145175326583435 mirMAP -0.248356026343056 7.21265255838416e-06 NA NA NA hsa-miR-146b-5p SESTD1 2.23105707690238 3.83997814011313e-23 0.340597060332946 0.0181887253507553 miRanda -0.11600543502269 0.00122467495110194 NA NA NA hsa-miR-200a-3p SESTD1 2.02394729844446 2.21240501925011e-08 0.340597060332946 0.0181887253507553 MirTarget -0.126899441482531 4.36900708558409e-08 NA NA NA hsa-miR-135b-5p SETBP1 2.80066701698235 2.12546333413447e-11 -1.30183425433718 5.52836218057813e-06 miRNATAP -0.373732755169286 5.02807412597839e-21 NA NA NA hsa-miR-200a-3p SETBP1 2.02394729844446 2.21240501925011e-08 -1.30183425433718 5.52836218057813e-06 miRNATAP -0.495678868330152 2.41329233846552e-31 NA NA NA hsa-miR-135b-5p SETD7 2.80066701698235 2.12546333413447e-11 -0.28906268449287 0.0651104635619279 MirTarget;mirMAP -0.152770480835625 5.25686390864252e-12 NA NA NA hsa-miR-146b-3p SETD7 2.08650140817622 5.3293570720033e-22 -0.28906268449287 0.0651104635619279 miRNATAP -0.201242329441087 5.43327570475191e-07 NA NA NA hsa-miR-200b-3p SETD7 2.06025765178663 3.07718049337497e-10 -0.28906268449287 0.0651104635619279 TargetScan -0.215063867888677 8.64274226154656e-16 NA NA NA hsa-miR-335-3p SETD7 2.29463721765513 4.1956113745077e-18 -0.28906268449287 0.0651104635619279 mirMAP -0.180939409129759 4.76583337957491e-08 NA NA NA hsa-miR-146b-5p SEZ6 2.23105707690238 3.83997814011313e-23 -0.37855737861185 0.334134858513673 miRanda -0.387373230279569 6.36633605669939e-05 NA NA NA hsa-miR-146b-5p SEZ6L 2.23105707690238 3.83997814011313e-23 -2.42658680253876 7.99299285888372e-09 miRanda -0.635721739585485 1.46971133803756e-09 NA NA NA hsa-miR-21-5p SEZ6L 2.21515015440792 6.0468197386674e-49 -2.42658680253876 7.99299285888372e-09 miRNATAP -0.918680255068037 1.15505609914213e-10 NA NA NA hsa-miR-335-3p SEZ6L 2.29463721765513 4.1956113745077e-18 -2.42658680253876 7.99299285888372e-09 mirMAP -0.648192293536288 5.35331372690459e-13 NA NA NA hsa-miR-200b-3p SFMBT2 2.06025765178663 3.07718049337497e-10 0.0835649026884502 0.675887099504741 mirMAP -0.170657714461283 1.39182313820134e-06 NA NA NA hsa-miR-335-3p SFMBT2 2.29463721765513 4.1956113745077e-18 0.0835649026884502 0.675887099504741 MirTarget -0.181530889617179 2.07907319824489e-05 NA NA NA hsa-miR-146b-5p SFRP1 2.23105707690238 3.83997814011313e-23 -3.56630377950387 4.00035101502398e-12 MirTarget -0.930827594577234 4.06992890317546e-13 NA NA NA hsa-miR-146b-5p SFRP5 2.23105707690238 3.83997814011313e-23 -2.96537398639758 1.22517552669937e-07 miRanda -0.785173092843259 2.08947641911538e-08 NA NA NA hsa-miR-192-5p SGCB 2.0867723747501 3.57854249239079e-08 -0.278110445030599 0.0486812755185084 miRNAWalker2_validate -0.146200769812761 6.57053487211193e-12 NA NA NA hsa-miR-21-5p SGCB 2.21515015440792 6.0468197386674e-49 -0.278110445030599 0.0486812755185084 miRNAWalker2_validate -0.187935917103744 7.59518628554128e-05 NA NA NA hsa-miR-335-3p SGCB 2.29463721765513 4.1956113745077e-18 -0.278110445030599 0.0486812755185084 mirMAP -0.170183951783631 1.05564412614467e-08 NA NA NA hsa-miR-146b-5p SGCD 2.23105707690238 3.83997814011313e-23 -0.462258493991732 0.100341438431502 mirMAP -0.366967391253636 9.6319394241692e-08 NA NA NA hsa-miR-200b-3p SGCD 2.06025765178663 3.07718049337497e-10 -0.462258493991732 0.100341438431502 mirMAP -0.501606488639052 5.13862084960906e-28 NA NA NA hsa-miR-335-3p SGCD 2.29463721765513 4.1956113745077e-18 -0.462258493991732 0.100341438431502 mirMAP -0.405351740937599 4.51407881233559e-12 NA NA NA hsa-miR-200b-3p SGCE 2.06025765178663 3.07718049337497e-10 -0.887861455136679 0.000291735874774958 TargetScan -0.452427921680518 9.16325755973155e-30 NA NA NA hsa-miR-146b-3p SGIP1 2.08650140817622 5.3293570720033e-22 0.300220569989602 0.133137161334211 MirTarget;PITA;miRNATAP -0.117010129638565 0.0250314636811122 NA NA NA hsa-miR-200b-3p SGIP1 2.06025765178663 3.07718049337497e-10 0.300220569989602 0.133137161334211 MirTarget;TargetScan -0.267656804124419 5.1286550669651e-15 NA NA NA hsa-miR-335-3p SGIP1 2.29463721765513 4.1956113745077e-18 0.300220569989602 0.133137161334211 MirTarget;mirMAP -0.195691162718129 4.40226913933053e-06 NA NA NA hsa-miR-200b-3p SGPP1 2.06025765178663 3.07718049337497e-10 -0.0486406169062992 0.740068844092372 MirTarget -0.120599348674916 3.32376349895321e-06 NA NA NA hsa-miR-200b-3p SGSM1 2.06025765178663 3.07718049337497e-10 -1.08363018550983 0.000441243932993226 mirMAP -0.197908280186059 0.000390148270995268 NA NA NA hsa-miR-335-3p SGSM1 2.29463721765513 4.1956113745077e-18 -1.08363018550983 0.000441243932993226 mirMAP -0.327667079771212 7.5272242457408e-07 NA NA NA hsa-miR-146b-5p SGSM2 2.23105707690238 3.83997814011313e-23 -0.437357566828462 0.000445753720304273 miRanda -0.134832068301393 1.28049006597033e-05 NA NA NA hsa-miR-335-3p SGTB 2.29463721765513 4.1956113745077e-18 0.184623734054838 0.179748534639541 MirTarget;mirMAP -0.134347256810317 4.44015972164908e-06 NA NA NA hsa-miR-135b-5p SH2D3C 2.80066701698235 2.12546333413447e-11 0.0274812860901856 0.866260576278742 MirTarget -0.105460432417898 7.80054993719046e-06 NA NA NA hsa-miR-146b-5p SH3BGR 2.23105707690238 3.83997814011313e-23 -1.62544342729191 2.88698739749401e-10 miRanda -0.598108753656997 2.06453301109388e-22 NA NA NA hsa-miR-146b-5p SH3BGRL 2.23105707690238 3.83997814011313e-23 -1.01273366672549 5.07140192738718e-08 miRanda -0.279764335408511 1.41814577329356e-09 NA NA NA hsa-miR-21-5p SH3BGRL2 2.21515015440792 6.0468197386674e-49 -0.846663351710699 1.27998770466782e-05 mirMAP -0.193707166612874 0.00375170675073065 NA NA NA hsa-miR-183-5p SH3D19 2.08412478942637 1.08931431254487e-10 -0.40589349119468 0.00593283404485438 miRNAWalker2_validate;MirTarget -0.165887396829302 2.1849658839124e-10 NA NA NA hsa-miR-146b-5p SH3GL2 2.23105707690238 3.83997814011313e-23 -4.46378118219411 1.17801358444675e-19 miRanda;miRNATAP -1.09204982217641 1.14993148315437e-18 NA NA NA hsa-miR-141-5p SH3PXD2A 2.13747696823946 1.73124674554872e-11 0.104519604538216 0.49534024563541 mirMAP -0.167074818263747 1.09664164655533e-09 NA NA NA hsa-miR-146b-5p SH3PXD2A 2.23105707690238 3.83997814011313e-23 0.104519604538216 0.49534024563541 mirMAP -0.138087950717776 0.000265737677484426 NA NA NA hsa-miR-192-5p SH3PXD2A 2.0867723747501 3.57854249239079e-08 0.104519604538216 0.49534024563541 mirMAP -0.176783472454838 8.89884634761065e-15 NA NA NA hsa-miR-194-5p SH3PXD2A 2.24386881692218 9.35116329002209e-11 0.104519604538216 0.49534024563541 mirMAP -0.175657149455023 1.76860284491355e-12 NA NA NA hsa-miR-200b-3p SH3PXD2A 2.06025765178663 3.07718049337497e-10 0.104519604538216 0.49534024563541 TargetScan -0.153850441505416 1.00664247564097e-08 NA NA NA hsa-miR-141-5p SH3PXD2B 2.13747696823946 1.73124674554872e-11 0.571146620240805 0.000639832838972146 mirMAP -0.222446684935071 7.26862497835603e-14 NA NA NA hsa-miR-200a-3p SH3PXD2B 2.02394729844446 2.21240501925011e-08 0.571146620240805 0.000639832838972146 mirMAP -0.207681720133038 2.60881376135513e-15 NA NA NA hsa-miR-192-5p SH3RF3 2.0867723747501 3.57854249239079e-08 0.47587124226221 0.0119272980352257 MirTarget;miRNATAP -0.197287552264824 5.93816800746329e-12 NA NA NA hsa-miR-146b-5p SHANK2 2.23105707690238 3.83997814011313e-23 0.0819100152541035 0.738152907294678 mirMAP -0.213260473329181 0.00043997824593782 NA NA NA hsa-miR-335-3p SHC4 2.29463721765513 4.1956113745077e-18 0.307563922742379 0.26608516346102 mirMAP -0.244470830539683 3.61381121038751e-05 NA NA NA hsa-miR-135b-5p SHE 2.80066701698235 2.12546333413447e-11 -0.487657055801679 0.0132219991840013 mirMAP -0.225380455698458 1.96686224080219e-16 NA NA NA hsa-miR-141-5p SHE 2.13747696823946 1.73124674554872e-11 -0.487657055801679 0.0132219991840013 mirMAP -0.30920687873161 8.9880944210249e-20 NA NA NA hsa-miR-146b-5p SHE 2.23105707690238 3.83997814011313e-23 -0.487657055801679 0.0132219991840013 mirMAP -0.128602472413671 0.00900986129425512 NA NA NA hsa-miR-192-5p SHE 2.0867723747501 3.57854249239079e-08 -0.487657055801679 0.0132219991840013 mirMAP -0.187568457592251 4.30071214285691e-10 NA NA NA hsa-miR-200a-3p SHE 2.02394729844446 2.21240501925011e-08 -0.487657055801679 0.0132219991840013 mirMAP -0.280860969782472 9.80967500018734e-21 NA NA NA hsa-miR-200b-3p SHE 2.06025765178663 3.07718049337497e-10 -0.487657055801679 0.0132219991840013 mirMAP -0.294668778558169 8.42906601610598e-19 NA NA NA hsa-miR-335-3p SHE 2.29463721765513 4.1956113745077e-18 -0.487657055801679 0.0132219991840013 mirMAP -0.304297660290091 8.55804189386097e-14 NA NA NA hsa-miR-183-5p SHISA2 2.08412478942637 1.08931431254487e-10 1.11799062553653 0.000261186958590419 miRNAWalker2_validate -0.111665912515352 0.0484229386147987 NA NA NA hsa-miR-935 SHISA3 2.321600496365 1.00042201726114e-07 -1.64807261781027 0.00073602954686962 MirTarget -0.478641248795321 2.50325795194928e-12 NA NA NA hsa-miR-135b-5p SHISA6 2.80066701698235 2.12546333413447e-11 -2.04347339683578 2.53339325503619e-06 MirTarget -0.184493169810059 0.00451834279637908 NA NA NA hsa-miR-146b-5p SHISA6 2.23105707690238 3.83997814011313e-23 -2.04347339683578 2.53339325503619e-06 mirMAP -0.364438469399743 0.00092483699214499 NA NA NA hsa-miR-200a-5p SHISA6 2.19152245759943 3.17968183522514e-11 -2.04347339683578 2.53339325503619e-06 miRNATAP -0.326601375099566 2.79919421525904e-05 NA NA NA hsa-miR-335-3p SHISA9 2.29463721765513 4.1956113745077e-18 -2.58089448015854 5.79194587621464e-07 mirMAP -0.772903759283698 1.83025929648748e-12 NA NA NA hsa-miR-935 SHISA9 2.321600496365 1.00042201726114e-07 -2.58089448015854 5.79194587621464e-07 miRNATAP -0.54965789607111 3.91396199860942e-14 NA NA NA hsa-miR-141-5p SHROOM4 2.13747696823946 1.73124674554872e-11 0.533433249282303 0.0033357310845142 mirMAP -0.145437240429581 1.29033628456656e-05 NA NA NA hsa-miR-200a-3p SHROOM4 2.02394729844446 2.21240501925011e-08 0.533433249282303 0.0033357310845142 mirMAP -0.151890528420416 2.43708339191551e-07 NA NA NA hsa-miR-200b-3p SHROOM4 2.06025765178663 3.07718049337497e-10 0.533433249282303 0.0033357310845142 TargetScan;mirMAP -0.137284559544724 2.49483560510638e-05 NA NA NA hsa-miR-935 SHROOM4 2.321600496365 1.00042201726114e-07 0.533433249282303 0.0033357310845142 mirMAP -0.121045354282659 3.18803925525617e-06 NA NA NA hsa-miR-200a-3p SIGLEC1 2.02394729844446 2.21240501925011e-08 0.342479979986158 0.187125409934616 mirMAP -0.161960653252941 0.000127587888819442 NA NA NA hsa-miR-335-3p SIGLEC11 2.29463721765513 4.1956113745077e-18 -2.02576267753758 2.60398411938477e-10 MirTarget -0.300751229588092 2.31862787879547e-05 NA NA NA hsa-miR-200a-3p SIK1 2.02394729844446 2.21240501925011e-08 -0.979960476351428 3.46198014263222e-06 MirTarget;miRNATAP -0.10231456711678 0.00366741911868666 NA NA NA hsa-miR-200a-3p SIK2 2.02394729844446 2.21240501925011e-08 -0.498358334486584 1.42722402092494e-05 MirTarget -0.101786573246876 4.8707855114905e-08 NA NA NA hsa-miR-200b-3p SIK2 2.06025765178663 3.07718049337497e-10 -0.498358334486584 1.42722402092494e-05 TargetScan -0.111935095693208 4.59557286723215e-08 NA NA NA hsa-miR-146b-5p SIK3 2.23105707690238 3.83997814011313e-23 -0.392823758857842 0.000118835285276331 miRanda -0.155351861704774 4.10570671199785e-10 NA NA NA hsa-miR-183-5p SIK3 2.08412478942637 1.08931431254487e-10 -0.392823758857842 0.000118835285276331 miRNATAP -0.156664563321447 3.33367333572683e-19 NA NA NA hsa-miR-200b-3p SIN3B 2.06025765178663 3.07718049337497e-10 0.241053378375932 0.00340544141164494 mirMAP -0.105403596093137 8.29624008758562e-14 NA NA NA hsa-miR-200a-3p SIPA1L2 2.02394729844446 2.21240501925011e-08 -0.0621530457804553 0.741518280681569 miRNATAP -0.15305356819836 4.37243263517283e-07 NA NA NA hsa-miR-21-5p SKI 2.21515015440792 6.0468197386674e-49 0.22417153228759 0.0311770228305296 MirTarget;miRNATAP -0.102503052687065 0.00357471230517725 NA NA NA hsa-miR-183-5p SLAIN1 2.08412478942637 1.08931431254487e-10 -1.15574308922584 0.000196099122990038 MirTarget;miRNATAP -0.250469345828702 9.37769924679705e-06 NA NA NA hsa-miR-141-5p SLAIN2 2.13747696823946 1.73124674554872e-11 -0.450230709640584 7.71615685568148e-08 MirTarget -0.134773933692077 3.22044384149912e-20 NA NA NA hsa-miR-146b-5p SLAIN2 2.23105707690238 3.83997814011313e-23 -0.450230709640584 7.71615685568148e-08 miRanda -0.135581053843386 3.93763641979407e-11 NA NA NA hsa-miR-21-5p SLAIN2 2.21515015440792 6.0468197386674e-49 -0.450230709640584 7.71615685568148e-08 miRNAWalker2_validate -0.1681255879034 2.38512698180717e-09 NA NA NA hsa-miR-335-3p SLAIN2 2.29463721765513 4.1956113745077e-18 -0.450230709640584 7.71615685568148e-08 mirMAP -0.112308816601211 3.19760320382038e-10 NA NA NA hsa-miR-335-3p SLAMF1 2.29463721765513 4.1956113745077e-18 -0.296887719392151 0.267834886075597 mirMAP -0.193190020010291 0.000804796204248209 NA NA NA hsa-miR-335-3p SLAMF6 2.29463721765513 4.1956113745077e-18 0.0381308817398245 0.898701789600947 mirMAP -0.198955761368991 0.0020354622349012 NA NA NA hsa-miR-133a-3p SLBP -2.63342156915404 5.72661351480585e-12 0.486856687337966 1.22732326060935e-05 MirTarget -0.134868707235342 1.26560397824226e-16 NA NA NA hsa-miR-92a-1-5p SLC13A4 2.04820501765632 9.32117486799495e-13 -0.178397983544839 0.482008168210695 MirTarget -0.143920452373008 0.00618524008808133 NA NA NA hsa-miR-200b-3p SLC14A1 2.06025765178663 3.07718049337497e-10 -0.774209953172634 0.00506651647534284 TargetScan -0.185002178087437 0.00019772588099434 NA NA NA hsa-miR-335-3p SLC14A1 2.29463721765513 4.1956113745077e-18 -0.774209953172634 0.00506651647534284 MirTarget;mirMAP -0.275852089529701 3.19559971469643e-06 NA NA NA hsa-miR-200b-3p SLC16A12 2.06025765178663 3.07718049337497e-10 -1.26040595915657 0.000101947417986622 mirMAP -0.40866684334472 5.8602187338036e-13 NA NA NA hsa-miR-335-3p SLC16A12 2.29463721765513 4.1956113745077e-18 -1.26040595915657 0.000101947417986622 MirTarget;mirMAP -0.415773752946036 1.76634693551394e-09 NA NA NA hsa-miR-146b-5p SLC16A14 2.23105707690238 3.83997814011313e-23 -0.128026574623716 0.572732236984336 PITA;miRanda -0.139332568405513 0.0137329021772414 NA NA NA hsa-miR-192-5p SLC16A14 2.0867723747501 3.57854249239079e-08 -0.128026574623716 0.572732236984336 miRNAWalker2_validate -0.146965368157999 2.94418251492928e-05 NA NA NA hsa-miR-200a-3p SLC16A14 2.02394729844446 2.21240501925011e-08 -0.128026574623716 0.572732236984336 MirTarget -0.116815730480061 0.00162334390773522 NA NA NA hsa-miR-200b-3p SLC16A2 2.06025765178663 3.07718049337497e-10 -0.392210629327451 0.126440512346252 TargetScan -0.217616487329425 1.77166449938593e-06 NA NA NA hsa-miR-192-5p SLC16A7 2.0867723747501 3.57854249239079e-08 -1.78740503823139 7.82439110480803e-09 miRNAWalker2_validate -0.297492890773225 9.3570187164918e-10 NA NA NA hsa-miR-200a-3p SLC16A7 2.02394729844446 2.21240501925011e-08 -1.78740503823139 7.82439110480803e-09 MirTarget;miRNATAP -0.278068731602605 5.71990308016062e-08 NA NA NA hsa-miR-335-3p SLC16A7 2.29463721765513 4.1956113745077e-18 -1.78740503823139 7.82439110480803e-09 MirTarget -0.536143536972615 1.91505267497778e-16 NA NA NA hsa-miR-194-5p SLC16A9 2.24386881692218 9.35116329002209e-11 -2.32499767094881 1.72575242459783e-07 miRNAWalker2_validate -0.185347791106115 0.0167098991208726 NA NA NA hsa-miR-135b-5p SLC1A2 2.80066701698235 2.12546333413447e-11 -1.12914228505416 0.00257760369109007 mirMAP -0.219018431929725 6.73046213383931e-05 NA NA NA hsa-miR-335-3p SLC1A2 2.29463721765513 4.1956113745077e-18 -1.12914228505416 0.00257760369109007 mirMAP -0.421590378848883 1.35913679595591e-07 NA NA NA hsa-miR-935 SLC1A2 2.321600496365 1.00042201726114e-07 -1.12914228505416 0.00257760369109007 MirTarget;PITA -0.264050479115158 8.14159245324397e-07 NA NA NA hsa-miR-200a-3p SLC1A7 2.02394729844446 2.21240501925011e-08 -1.15428586562544 0.000760498174169026 MirTarget -0.289261444987792 2.07945990493863e-07 NA NA NA hsa-miR-335-3p SLC22A15 2.29463721765513 4.1956113745077e-18 0.0458373053158778 0.827597858846841 mirMAP -0.12206032149425 0.00714852303814134 NA NA NA hsa-miR-192-5p SLC23A2 2.0867723747501 3.57854249239079e-08 -0.0699749852409353 0.607901925455689 mirMAP -0.101883586037439 1.17127214354927e-06 NA NA NA hsa-miR-200a-3p SLC23A2 2.02394729844446 2.21240501925011e-08 -0.0699749852409353 0.607901925455689 miRNATAP -0.121173975738383 2.64199914588166e-08 NA NA NA hsa-miR-200b-3p SLC23A2 2.06025765178663 3.07718049337497e-10 -0.0699749852409353 0.607901925455689 TargetScan -0.130961406035207 4.43770228324087e-08 NA NA NA hsa-miR-200a-3p SLC24A4 2.02394729844446 2.21240501925011e-08 -0.889410656770861 9.42341078455181e-05 mirMAP -0.28270955960388 3.64836811925897e-15 NA NA NA hsa-miR-200b-3p SLC24A4 2.06025765178663 3.07718049337497e-10 -0.889410656770861 9.42341078455181e-05 TargetScan -0.307811828843244 6.47994611572205e-15 NA NA NA hsa-miR-335-3p SLC24A4 2.29463721765513 4.1956113745077e-18 -0.889410656770861 9.42341078455181e-05 mirMAP -0.268011859939272 3.87497771124852e-08 NA NA NA hsa-miR-335-3p SLC25A21 2.29463721765513 4.1956113745077e-18 -1.30481585427009 0.000118966897386269 mirMAP -0.192616280785626 0.00946883394605388 NA NA NA hsa-miR-92a-1-5p SLC25A23 2.04820501765632 9.32117486799495e-13 -0.927049405641669 4.99164561343223e-09 MirTarget -0.192870687140864 5.10863019824973e-09 NA NA NA hsa-miR-146b-5p SLC25A26 2.23105707690238 3.83997814011313e-23 -0.394703690472408 0.00169663064559881 miRanda -0.204430647012134 1.69088922893072e-11 NA NA NA hsa-miR-335-3p SLC25A26 2.29463721765513 4.1956113745077e-18 -0.394703690472408 0.00169663064559881 mirMAP -0.167568794650041 2.39529488320708e-10 NA NA NA hsa-miR-146b-5p SLC25A27 2.23105707690238 3.83997814011313e-23 -0.585454848942062 0.0804326193287128 MirTarget;miRanda -0.377839350958433 4.6954982972266e-06 NA NA NA hsa-miR-194-5p SLC25A27 2.24386881692218 9.35116329002209e-11 -0.585454848942062 0.0804326193287128 MirTarget -0.319636527139547 8.63411457288256e-09 NA NA NA hsa-miR-146b-5p SLC25A34 2.23105707690238 3.83997814011313e-23 -1.88037759867894 6.71309173262929e-11 miRanda -0.305605064048097 3.5618024091032e-05 NA NA NA hsa-miR-935 SLC25A4 2.321600496365 1.00042201726114e-07 -1.85054169360808 8.64749270739735e-17 miRNATAP -0.237912956519257 3.35279942811158e-13 NA NA NA hsa-miR-200a-3p SLC25A42 2.02394729844446 2.21240501925011e-08 -1.05200247887537 2.2352642569216e-14 mirMAP -0.151724315684617 3.84347592870575e-11 NA NA NA hsa-miR-335-3p SLC25A53 2.29463721765513 4.1956113745077e-18 -0.191833055585313 0.196395999658306 mirMAP -0.116953526072981 0.000237664475027273 NA NA NA hsa-miR-135b-5p SLC26A4 2.80066701698235 2.12546333413447e-11 -0.801207194769778 0.000290476801394734 MirTarget -0.206876138689714 7.00113756416652e-11 NA NA NA hsa-miR-335-3p SLC26A4 2.29463721765513 4.1956113745077e-18 -0.801207194769778 0.000290476801394734 mirMAP -0.272554825914283 7.13972097531593e-09 NA NA NA hsa-miR-18a-5p SLC27A1 2.04701000113742 1.30593450319289e-12 -0.0200774633523899 0.892362945441898 mirMAP -0.169593447801574 6.18264194344039e-09 NA NA NA hsa-miR-146b-5p SLC27A3 2.23105707690238 3.83997814011313e-23 -0.248468414280113 0.0606989594780144 miRanda -0.129361348627004 7.67040555711386e-05 NA NA NA hsa-miR-1-3p SLC28A3 -2.73171785118192 3.4424534921136e-12 1.82217298473182 4.28127812120058e-06 MirTarget -0.232060181638056 9.90239360900286e-05 NA NA NA hsa-miR-335-3p SLC2A12 2.29463721765513 4.1956113745077e-18 -1.72811318813712 1.96625081357168e-10 mirMAP -0.267245455849169 8.7984413785439e-06 NA NA NA hsa-miR-146b-5p SLC2A13 2.23105707690238 3.83997814011313e-23 -0.330767398658062 0.0365814104558294 mirMAP -0.102935089318202 0.00913165335010345 NA NA NA hsa-miR-200b-3p SLC2A3 2.06025765178663 3.07718049337497e-10 0.21944182973729 0.225968938814907 TargetScan -0.112911156544842 0.000498117825800863 NA NA NA hsa-miR-92a-1-5p SLC2A4 2.04820501765632 9.32117486799495e-13 -2.41796075460274 1.09847746343808e-09 miRNAWalker2_validate -0.730026598510965 3.16746172755736e-20 NA NA NA hsa-miR-200b-3p SLC30A4 2.06025765178663 3.07718049337497e-10 -0.916717603824858 1.25143222073552e-07 mirMAP -0.119235558641125 0.000172940562399557 NA NA NA hsa-miR-335-3p SLC30A4 2.29463721765513 4.1956113745077e-18 -0.916717603824858 1.25143222073552e-07 mirMAP -0.186258256425066 8.01542202071051e-07 NA NA NA hsa-miR-133a-3p SLC30A7 -2.63342156915404 5.72661351480585e-12 0.656783217262733 6.71791536437343e-10 MirTarget -0.121174711409637 3.72785869550116e-14 NA NA NA hsa-miR-146b-3p SLC30A8 2.08650140817622 5.3293570720033e-22 -2.65731049044966 2.93491403185427e-09 PITA;miRNATAP -0.684029126293003 5.90911747459127e-09 NA NA NA hsa-miR-194-5p SLC30A8 2.24386881692218 9.35116329002209e-11 -2.65731049044966 2.93491403185427e-09 MirTarget;miRNATAP -0.50269076078748 3.23813222463607e-11 NA NA NA hsa-miR-335-3p SLC30A8 2.29463721765513 4.1956113745077e-18 -2.65731049044966 2.93491403185427e-09 mirMAP -0.737320845686693 8.83013944162975e-15 NA NA NA hsa-miR-18a-5p SLC35F1 2.04701000113742 1.30593450319289e-12 -1.08928528951736 0.000468430757191153 mirMAP -0.474561940028846 4.54057936535434e-15 NA NA NA hsa-miR-335-3p SLC35F1 2.29463721765513 4.1956113745077e-18 -1.08928528951736 0.000468430757191153 mirMAP -0.449730445500909 6.48259132666926e-12 NA NA NA hsa-miR-192-5p SLC35F3 2.0867723747501 3.57854249239079e-08 -1.63319200376934 4.64079893828067e-05 miRNAWalker2_validate -0.23513436706983 0.000207434956310952 NA NA NA hsa-miR-194-5p SLC35F3 2.24386881692218 9.35116329002209e-11 -1.63319200376934 4.64079893828067e-05 miRNATAP -0.28119439370544 3.92875946276761e-05 NA NA NA hsa-miR-335-3p SLC35G2 2.29463721765513 4.1956113745077e-18 0.111673677566994 0.5384906148913 MirTarget -0.110826820527824 0.00459518657239491 NA NA NA hsa-miR-146b-5p SLC36A4 2.23105707690238 3.83997814011313e-23 -0.0729655400034188 0.718281341181789 miRanda -0.166097377854519 0.000920308640491465 NA NA NA hsa-miR-200a-5p SLC36A4 2.19152245759943 3.17968183522514e-11 -0.0729655400034188 0.718281341181789 mirMAP -0.131941194268874 0.000214486622166648 NA NA NA hsa-miR-146b-5p SLC38A1 2.23105707690238 3.83997814011313e-23 0.165523798697978 0.414141102706905 miRanda;miRNATAP -0.132352489448968 0.00870722265625875 NA NA NA hsa-miR-146b-5p SLC3A1 2.23105707690238 3.83997814011313e-23 -0.356609221669228 0.181870236682026 miRanda -0.143782864548522 0.0312357340952664 NA NA NA hsa-miR-1-3p SLC44A1 -2.73171785118192 3.4424534921136e-12 0.434756218586184 0.000117325296006433 MirTarget -0.136982684543028 6.88835102197144e-18 NA NA NA hsa-miR-192-5p SLC48A1 2.0867723747501 3.57854249239079e-08 -0.514682081934797 3.48999885269257e-07 miRNAWalker2_validate -0.135810540441527 1.66974940976454e-19 NA NA NA hsa-miR-335-3p SLC4A10 2.29463721765513 4.1956113745077e-18 -1.09406218383628 0.00152401130426941 mirMAP -0.149205678009171 0.0479152299434883 NA NA NA hsa-miR-146b-5p SLC5A9 2.23105707690238 3.83997814011313e-23 -1.3286295089522 0.00105907707084601 miRanda -0.238386817841278 0.0197133626447577 NA NA NA hsa-miR-200b-3p SLC6A1 2.06025765178663 3.07718049337497e-10 0.994406984622405 9.59593686334557e-05 MirTarget;TargetScan -0.167134338095253 0.000299100429838722 NA NA NA hsa-miR-18a-5p SLC6A11 2.04701000113742 1.30593450319289e-12 -0.837595880554685 0.0996275345445822 mirMAP -0.24340149182958 0.0184602334678271 NA NA NA hsa-miR-200b-3p SLC6A11 2.06025765178663 3.07718049337497e-10 -0.837595880554685 0.0996275345445822 TargetScan -0.211845907785713 0.0211400529635181 NA NA NA hsa-miR-146b-5p SLC6A15 2.23105707690238 3.83997814011313e-23 -2.37276785545784 1.70421464548129e-05 miRanda -0.963173755141469 6.96024503482968e-13 NA NA NA hsa-miR-196b-5p SLC6A15 4.51951031652328 7.04026169031626e-18 -2.37276785545784 1.70421464548129e-05 miRNAWalker2_validate -0.306243714763014 3.0876218376812e-07 NA NA NA hsa-miR-200a-3p SLC6A17 2.02394729844446 2.21240501925011e-08 -0.923464521615343 0.00716410237201486 miRNATAP -0.344434198923837 3.6622888546989e-10 NA NA NA hsa-miR-200b-3p SLC6A17 2.06025765178663 3.07718049337497e-10 -0.923464521615343 0.00716410237201486 TargetScan;mirMAP -0.399426550851497 2.89430991681926e-11 NA NA NA hsa-miR-92a-1-5p SLC6A17 2.04820501765632 9.32117486799495e-13 -0.923464521615343 0.00716410237201486 mirMAP -0.164002684981636 0.0223430444144314 NA NA NA hsa-miR-146b-5p SLC6A4 2.23105707690238 3.83997814011313e-23 -3.68262138749367 4.59780243174991e-13 miRanda -0.60723303517643 3.7408777677726e-06 NA NA NA hsa-miR-935 SLC6A4 2.321600496365 1.00042201726114e-07 -3.68262138749367 4.59780243174991e-13 MirTarget -0.248623129085136 0.00119145702433327 NA NA NA hsa-miR-146b-3p SLC7A10 2.08650140817622 5.3293570720033e-22 -0.278164034375104 0.467925807981772 MirTarget;PITA -0.213937435373139 0.0325948164747945 NA NA NA hsa-miR-192-5p SLC7A2 2.0867723747501 3.57854249239079e-08 -0.504055476896812 0.159045414836461 miRNAWalker2_validate -0.29980255271074 4.91686651391359e-08 NA NA NA hsa-miR-335-3p SLC7A2 2.29463721765513 4.1956113745077e-18 -0.504055476896812 0.159045414836461 MirTarget -0.288292587299889 0.00017737277743156 NA NA NA hsa-miR-194-5p SLC7A5 2.24386881692218 9.35116329002209e-11 0.291329294755172 0.24317758713055 MirTarget -0.125453234835384 0.0029930968328574 NA NA NA hsa-miR-135b-5p SLC8A1 2.80066701698235 2.12546333413447e-11 -0.488144209721238 0.0306197817555203 MirTarget -0.267027996095641 1.30664232428241e-17 NA NA NA hsa-miR-196a-5p SLC8A2 5.05945965885472 4.48343841468539e-25 -1.94560053225014 0.000346923202109352 miRNATAP -0.268790126061518 1.7794346750029e-05 NA NA NA hsa-miR-196b-5p SLC8A2 4.51951031652328 7.04026169031626e-18 -1.94560053225014 0.000346923202109352 miRNATAP -0.33325636431854 1.09689486754293e-08 NA NA NA hsa-miR-135b-5p SLC9A9 2.80066701698235 2.12546333413447e-11 -1.54075414116007 2.14658981763962e-11 MirTarget -0.301959554336243 2.65850662365248e-20 NA NA NA hsa-miR-935 SLC9B2 2.321600496365 1.00042201726114e-07 0.00882390231280317 0.970300222440012 MirTarget -0.10821175718348 0.0014628372346563 NA NA NA hsa-miR-133a-3p SLCO1B3 -2.63342156915404 5.72661351480585e-12 2.97561861183131 8.74615293420083e-05 MirTarget -0.25866939563728 0.0284010396828648 NA NA NA hsa-miR-335-3p SLCO2A1 2.29463721765513 4.1956113745077e-18 -0.785502330617711 0.000822752357568261 mirMAP -0.274911617709752 4.05668560747563e-08 NA NA NA hsa-miR-192-5p SLCO3A1 2.0867723747501 3.57854249239079e-08 0.704723025360271 0.000172885275405704 miRNAWalker2_validate -0.137933155360781 2.53321412148695e-06 NA NA NA hsa-miR-183-5p SLIT1 2.08412478942637 1.08931431254487e-10 -0.365585149990502 0.250900214858334 mirMAP -0.120704264110127 0.0379206222539102 NA NA NA hsa-miR-200b-3p SLIT2 2.06025765178663 3.07718049337497e-10 -1.0749206484349 0.0038634611143328 TargetScan -0.675850836377661 6.79363483823133e-29 NA NA NA hsa-miR-135b-5p SLIT3 2.80066701698235 2.12546333413447e-11 -0.724230127950243 0.0119623193624327 mirMAP -0.29011291222578 1.16205828267869e-12 NA NA NA hsa-miR-192-5p SLIT3 2.0867723747501 3.57854249239079e-08 -0.724230127950243 0.0119623193624327 mirMAP -0.325763197394481 5.58148510646795e-14 NA NA NA hsa-miR-335-3p SLIT3 2.29463721765513 4.1956113745077e-18 -0.724230127950243 0.0119623193624327 mirMAP -0.329635418384113 7.48247588033606e-08 NA NA NA hsa-miR-146b-5p SLITRK2 2.23105707690238 3.83997814011313e-23 -1.53434096007965 0.00068406491872432 miRanda -0.489515815364986 1.35109947867791e-05 NA NA NA hsa-miR-146b-5p SLITRK3 2.23105707690238 3.83997814011313e-23 -3.32762653086661 8.86043772005427e-10 miRNATAP -1.13841343579708 4.9046044643617e-18 NA NA NA hsa-miR-183-5p SLITRK3 2.08412478942637 1.08931431254487e-10 -3.32762653086661 8.86043772005427e-10 miRNATAP -1.01950558024148 1.78167484198203e-28 NA NA NA hsa-miR-135b-5p SLITRK4 2.80066701698235 2.12546333413447e-11 -0.964000012557656 0.00743416708305731 MirTarget -0.317342732438383 8.11648320828756e-10 NA NA NA hsa-miR-146b-3p SLITRK4 2.08650140817622 5.3293570720033e-22 -0.964000012557656 0.00743416708305731 MirTarget -0.188985187454879 0.046015132660684 NA NA NA hsa-miR-146b-5p SLITRK4 2.23105707690238 3.83997814011313e-23 -0.964000012557656 0.00743416708305731 miRNATAP -0.255253465316758 0.0046588489293633 NA NA NA hsa-miR-192-5p SLITRK4 2.0867723747501 3.57854249239079e-08 -0.964000012557656 0.00743416708305731 miRNATAP -0.47629740984611 2.69989425538692e-19 NA NA NA hsa-miR-200a-5p SLITRK4 2.19152245759943 3.17968183522514e-11 -0.964000012557656 0.00743416708305731 miRNATAP -0.530085644807088 1.52691647299259e-18 NA NA NA hsa-miR-335-3p SLITRK6 2.29463721765513 4.1956113745077e-18 -2.12072897573877 2.09979907357866e-06 MirTarget -0.566962246538317 3.56378731223667e-09 NA NA NA hsa-miR-21-5p SLMAP 2.21515015440792 6.0468197386674e-49 -0.731049756779606 4.09382011272657e-05 miRNAWalker2_validate;MirTarget -0.374641831854935 2.97310314620869e-10 NA NA NA hsa-miR-335-3p SLMAP 2.29463721765513 4.1956113745077e-18 -0.731049756779606 4.09382011272657e-05 mirMAP -0.30091101229793 3.63765664784083e-16 NA NA NA hsa-miR-146b-5p SMAD4 2.23105707690238 3.83997814011313e-23 -0.31259096016241 0.0041260218763756 PITA;miRanda;miRNATAP -0.107002098376942 7.30024432164399e-05 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-18a-5p SMAD4 2.04701000113742 1.30593450319289e-12 -0.31259096016241 0.0041260218763756 miRNAWalker2_validate -0.102223897399558 2.68354883367347e-06 NA NA NA hsa-miR-200b-3p SMAD9 2.06025765178663 3.07718049337497e-10 -1.3017262581652 4.19826165756804e-05 TargetScan -0.440772198294869 1.17201241753696e-15 NA NA NA hsa-miR-335-3p SMAD9 2.29463721765513 4.1956113745077e-18 -1.3017262581652 4.19826165756804e-05 mirMAP -0.487781671740611 2.6568674435523e-13 NA NA NA hsa-miR-192-5p SMARCA2 2.0867723747501 3.57854249239079e-08 -0.528624116298568 0.000138860805442413 miRNAWalker2_validate -0.145188705679969 6.6385021458089e-12 NA NA NA hsa-miR-146b-5p SMOC1 2.23105707690238 3.83997814011313e-23 -0.251508715588007 0.608476660049476 miRanda -0.46633100298116 0.000122944355634287 NA NA NA hsa-miR-146b-5p SMPX 2.23105707690238 3.83997814011313e-23 -1.65108210326525 0.0211461666317441 miRanda -1.09953377007652 2.53790860831448e-10 NA NA NA hsa-miR-335-3p SMYD1 2.29463721765513 4.1956113745077e-18 -2.00985612019053 0.0186634244825859 mirMAP -1.22914809882255 5.93754225552203e-12 NA NA NA hsa-miR-200b-3p SNAI2 2.06025765178663 3.07718049337497e-10 -0.0530603959694083 0.773251196834074 TargetScan -0.165498559433967 3.49597886475489e-07 NA NA NA hsa-miR-335-3p SNAI2 2.29463721765513 4.1956113745077e-18 -0.0530603959694083 0.773251196834074 mirMAP -0.122677549995067 0.00194765660408828 NA NA NA hsa-miR-200b-3p SNAP25 2.06025765178663 3.07718049337497e-10 -1.88036551123256 0.000140837414790177 MirTarget;TargetScan -0.743716900905436 1.19213621979677e-18 NA NA NA hsa-miR-200a-3p SNAP91 2.02394729844446 2.21240501925011e-08 -2.31409029923857 1.33149059257072e-05 miRNATAP -0.792871334909796 3.32360829708437e-22 NA NA NA hsa-miR-335-3p SNAP91 2.29463721765513 4.1956113745077e-18 -2.31409029923857 1.33149059257072e-05 mirMAP -0.903161930769595 2.96700676770898e-16 NA NA NA hsa-miR-146b-3p SNAPC2 2.08650140817622 5.3293570720033e-22 -0.212521128641312 0.057784217774229 miRNATAP -0.108306031055247 0.000181616270320745 NA NA NA hsa-miR-18a-5p SNED1 2.04701000113742 1.30593450319289e-12 0.122555173975949 0.468426959436604 mirMAP -0.246285507466578 3.99082104440055e-14 NA NA NA hsa-miR-146b-3p SNPH 2.08650140817622 5.3293570720033e-22 -1.29466285306085 6.50266441128737e-07 MirTarget -0.42890456644812 1.71501034903562e-10 NA NA NA hsa-miR-146b-5p SNPH 2.23105707690238 3.83997814011313e-23 -1.29466285306085 6.50266441128737e-07 miRanda -0.439610127425523 5.66106063567929e-12 NA NA NA hsa-miR-21-5p SNRK 2.21515015440792 6.0468197386674e-49 -0.440363445705636 2.69716836697876e-05 miRNAWalker2_validate -0.20137262202129 9.70139742757545e-09 NA NA NA hsa-miR-335-3p SNRK 2.29463721765513 4.1956113745077e-18 -0.440363445705636 2.69716836697876e-05 mirMAP -0.154899039393063 1.90115997721335e-12 NA NA NA hsa-miR-146b-5p SNRPN 2.23105707690238 3.83997814011313e-23 -1.86869588163416 1.08435437482011e-15 miRanda -0.356935344617186 2.60368845434499e-09 NA NA NA hsa-miR-135b-5p SNTA1 2.80066701698235 2.12546333413447e-11 -1.33921099833907 2.60749375390736e-09 MirTarget -0.217479567938103 3.92887400660009e-11 NA NA NA hsa-miR-146b-5p SNX1 2.23105707690238 3.83997814011313e-23 -0.511472902760471 5.88177402398954e-11 mirMAP -0.155790101165884 1.94254519562685e-16 NA NA NA hsa-miR-183-5p SNX1 2.08412478942637 1.08931431254487e-10 -0.511472902760471 5.88177402398954e-11 MirTarget -0.138638053808935 2.85507981778906e-25 NA NA NA hsa-miR-194-5p SNX1 2.24386881692218 9.35116329002209e-11 -0.511472902760471 5.88177402398954e-11 MirTarget -0.128768846927558 4.13422547641314e-25 NA NA NA hsa-miR-200a-5p SNX1 2.19152245759943 3.17968183522514e-11 -0.511472902760471 5.88177402398954e-11 mirMAP -0.132223410342148 5.59873808921146e-24 NA NA NA hsa-miR-21-5p SNX1 2.21515015440792 6.0468197386674e-49 -0.511472902760471 5.88177402398954e-11 mirMAP -0.226062932239125 9.01017576631568e-19 NA NA NA hsa-miR-335-3p SNX1 2.29463721765513 4.1956113745077e-18 -0.511472902760471 5.88177402398954e-11 mirMAP -0.12435757596795 6.62516739055952e-14 NA NA NA hsa-miR-141-5p SNX18 2.13747696823946 1.73124674554872e-11 -0.394023571872575 0.000518416907785833 miRNATAP -0.116048683207344 1.69972481421497e-08 NA NA NA hsa-miR-200b-3p SNX18 2.06025765178663 3.07718049337497e-10 -0.394023571872575 0.000518416907785833 mirMAP -0.111531459275935 2.84040406357271e-08 NA NA NA hsa-miR-335-3p SNX18 2.29463721765513 4.1956113745077e-18 -0.394023571872575 0.000518416907785833 mirMAP -0.160787859824771 1.37999149589836e-11 NA NA NA hsa-miR-146b-5p SNX19 2.23105707690238 3.83997814011313e-23 -0.409444159065982 0.00360811952873335 miRanda -0.176694306138394 3.21913499676054e-07 NA NA NA hsa-miR-335-3p SNX19 2.29463721765513 4.1956113745077e-18 -0.409444159065982 0.00360811952873335 mirMAP -0.1460472807773 1.16728420118916e-06 NA NA NA hsa-miR-146b-5p SNX21 2.23105707690238 3.83997814011313e-23 -0.540682527205882 1.24300208179664e-05 miRanda;miRNATAP -0.216021862809547 5.55235931654309e-13 NA NA NA hsa-miR-335-3p SNX24 2.29463721765513 4.1956113745077e-18 -0.897577664752862 2.37702095705259e-10 mirMAP -0.159646731605496 2.82975031677804e-07 NA NA NA hsa-miR-135b-5p SNX29 2.80066701698235 2.12546333413447e-11 -0.339716650805053 0.0137138952600201 mirMAP -0.144057588143011 1.03512844980627e-13 NA NA NA hsa-miR-194-5p SNX29 2.24386881692218 9.35116329002209e-11 -0.339716650805053 0.0137138952600201 miRNATAP -0.225207092288598 3.35179742192073e-26 NA NA NA hsa-miR-196a-5p SNX29 5.05945965885472 4.48343841468539e-25 -0.339716650805053 0.0137138952600201 mirMAP -0.101309740722735 4.19310548387324e-11 NA NA NA hsa-miR-21-5p SNX29 2.21515015440792 6.0468197386674e-49 -0.339716650805053 0.0137138952600201 miRNATAP -0.215538817253791 3.12497746573708e-06 NA NA NA hsa-miR-92a-1-5p SNX29 2.04820501765632 9.32117486799495e-13 -0.339716650805053 0.0137138952600201 mirMAP -0.129323116123827 4.77314904546427e-06 NA NA NA hsa-miR-200a-5p SNX29P2 2.19152245759943 3.17968183522514e-11 0.399886980320901 0.146106708497449 mirMAP -0.204230439955054 1.26924292705051e-05 NA NA NA hsa-miR-146b-3p SNX32 2.08650140817622 5.3293570720033e-22 -1.35002166419196 1.33341461267745e-06 miRNATAP -0.287952442458397 9.43645060876284e-05 NA NA NA hsa-miR-146b-5p SNX32 2.23105707690238 3.83997814011313e-23 -1.35002166419196 1.33341461267745e-06 miRanda -0.401239283194102 7.05495665538146e-09 NA NA NA hsa-miR-18a-5p SNX33 2.04701000113742 1.30593450319289e-12 -0.406179272526267 8.61998713175728e-05 mirMAP -0.140034140789952 5.43459559716723e-12 NA NA NA hsa-miR-146b-5p SOAT2 2.23105707690238 3.83997814011313e-23 -1.51659139388544 0.00363542681833895 miRanda -0.295343366739206 0.0243579496157325 NA NA NA hsa-miR-146b-5p SOBP 2.23105707690238 3.83997814011313e-23 -1.12034295311418 4.54379562785856e-05 miRanda -0.519324455616918 3.59255668350144e-15 NA NA NA hsa-miR-200a-3p SOBP 2.02394729844446 2.21240501925011e-08 -1.12034295311418 4.54379562785856e-05 MirTarget -0.426327015575602 2.02174256853066e-24 NA NA NA hsa-miR-335-3p SOBP 2.29463721765513 4.1956113745077e-18 -1.12034295311418 4.54379562785856e-05 MirTarget;mirMAP -0.413937417667447 7.78875006478786e-13 NA NA NA hsa-miR-194-5p SOCS2 2.24386881692218 9.35116329002209e-11 -1.10044523318765 6.64329026112842e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.14746253020015 1.6672323768358e-06 22102710 Functional studies indicated that CDKN1A/p21 and SOCS2 expression is directly regulated by miR-20a/-20b and miR-194 respectively; miR-20a/b and miR-194 target CDKN1A and SOCS2 in follicular lymphoma potentially contributing to tumor cell proliferation and survival poor survival lymphoma hsa-miR-146b-5p SOD3 2.23105707690238 3.83997814011313e-23 -0.930102971360054 0.000795497639706759 miRanda -0.411543204499784 1.30310814612275e-09 NA NA NA hsa-miR-21-5p SOD3 2.21515015440792 6.0468197386674e-49 -0.930102971360054 0.000795497639706759 miRNAWalker2_validate;miRTarBase -0.537791284895313 6.51564542517929e-09 NA NA NA hsa-miR-146b-5p SOGA1 2.23105707690238 3.83997814011313e-23 0.164842490647963 0.469140269986253 mirMAP -0.261894282771798 2.79190563881051e-06 NA NA NA hsa-miR-183-5p SOGA1 2.08412478942637 1.08931431254487e-10 0.164842490647963 0.469140269986253 mirMAP -0.220409831773124 5.47876081302226e-08 NA NA NA hsa-miR-18a-5p SOGA1 2.04701000113742 1.30593450319289e-12 0.164842490647963 0.469140269986253 mirMAP -0.211933294609503 3.03641181586955e-06 NA NA NA hsa-miR-335-3p SOGA1 2.29463721765513 4.1956113745077e-18 0.164842490647963 0.469140269986253 mirMAP -0.153816832463648 0.0016980305310947 NA NA NA hsa-miR-935 SOGA1 2.321600496365 1.00042201726114e-07 0.164842490647963 0.469140269986253 miRNATAP -0.163455732884371 3.88694547666988e-07 NA NA NA hsa-miR-146b-5p SOGA3 2.23105707690238 3.83997814011313e-23 -1.45935044862323 6.09769266940826e-06 mirMAP -0.572542102443582 2.8753226476183e-13 NA NA NA hsa-miR-335-3p SOGA3 2.29463721765513 4.1956113745077e-18 -1.45935044862323 6.09769266940826e-06 mirMAP -0.56055338114341 5.63259141493241e-17 NA NA NA hsa-miR-146b-5p SORBS1 2.23105707690238 3.83997814011313e-23 -1.66170973549782 2.54618514750915e-06 miRanda -0.76875397079324 3.67917790406981e-20 NA NA NA hsa-miR-18a-5p SORBS2 2.04701000113742 1.30593450319289e-12 -1.79771721889002 7.68088159150776e-09 MirTarget;miRNATAP -0.520227335782834 1.67981283155984e-17 NA NA NA hsa-miR-200a-3p SORBS2 2.02394729844446 2.21240501925011e-08 -1.79771721889002 7.68088159150776e-09 MirTarget -0.427741375057594 4.68577184274635e-18 NA NA NA hsa-miR-935 SORBS2 2.321600496365 1.00042201726114e-07 -1.79771721889002 7.68088159150776e-09 MirTarget;PITA -0.342457678531187 6.98003926154199e-15 NA NA NA hsa-miR-196a-5p SORCS1 5.05945965885472 4.48343841468539e-25 -3.49208496111718 2.56798323400443e-11 miRNATAP -0.469411911785733 3.55811510422827e-15 NA NA NA hsa-miR-196b-5p SORCS1 4.51951031652328 7.04026169031626e-18 -3.49208496111718 2.56798323400443e-11 miRNATAP -0.451611340288853 8.55264449817424e-16 NA NA NA hsa-miR-196a-5p SORCS2 5.05945965885472 4.48343841468539e-25 -0.222528937578638 0.425297184482372 mirMAP -0.118449472026209 0.0002047577165791 NA NA NA hsa-miR-146b-3p SORT1 2.08650140817622 5.3293570720033e-22 -0.107011524251647 0.42103417000941 MirTarget;PITA;miRNATAP -0.14825313728553 1.42393365692283e-05 NA NA NA hsa-miR-146b-5p SORT1 2.23105707690238 3.83997814011313e-23 -0.107011524251647 0.42103417000941 MirTarget;miRanda;miRNATAP -0.147026350481091 6.52427007641493e-06 NA NA NA hsa-miR-146b-5p SOS2 2.23105707690238 3.83997814011313e-23 -0.42663804059683 1.0961050076461e-05 miRanda -0.109254206460606 5.94271976028763e-06 NA NA NA hsa-miR-21-5p SOS2 2.21515015440792 6.0468197386674e-49 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.110175887586637 0.000892255788702267 NA NA NA hsa-miR-146b-5p SOX10 2.23105707690238 3.83997814011313e-23 -2.91572852256965 8.62031299963275e-11 miRanda -0.837541808374907 4.7607140567065e-14 NA NA NA hsa-miR-200a-3p SOX11 2.02394729844446 2.21240501925011e-08 2.67995156379045 3.65206596209455e-12 miRNATAP -0.163503111993804 0.0134358943095243 NA NA NA hsa-miR-21-5p SOX2 2.21515015440792 6.0468197386674e-49 -2.14859025311565 0.00035012271767378 miRNAWalker2_validate;miRNATAP -0.729903923617438 0.000377917304316825 26558781 Mir 21 Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact; Here we report that the stemness regulator Sox2 is a new clinically important target of microRNA-21 miR-21 in GBM with implications for prognosis; Further analysis of the miR-21-Sox2 relationship in mouse neural stem cells and in the mouse brain at different developmental stages indicates that miR-21 and Sox2 are predominantly expressed in mutually exclusive patterns suggesting a role in normal neural development worse prognosis;staging glioblastoma hsa-miR-146b-5p SOX5 2.23105707690238 3.83997814011313e-23 -1.09083873380211 3.82011335261816e-05 miRNATAP -0.442516121328806 7.00120717963709e-12 NA NA NA hsa-miR-194-5p SOX5 2.24386881692218 9.35116329002209e-11 -1.09083873380211 3.82011335261816e-05 miRNAWalker2_validate;miRTarBase -0.305658128044367 3.1724639015086e-12 NA NA NA hsa-miR-200a-3p SOX5 2.02394729844446 2.21240501925011e-08 -1.09083873380211 3.82011335261816e-05 miRNATAP -0.349600563754437 3.87852272107764e-17 NA NA NA hsa-miR-200b-3p SOX5 2.06025765178663 3.07718049337497e-10 -1.09083873380211 3.82011335261816e-05 TargetScan -0.38516161071944 2.87477272822889e-17 NA NA NA hsa-miR-21-5p SOX5 2.21515015440792 6.0468197386674e-49 -1.09083873380211 3.82011335261816e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.588926984125464 2.30670444869962e-11 NA NA NA hsa-miR-335-3p SOX5 2.29463721765513 4.1956113745077e-18 -1.09083873380211 3.82011335261816e-05 mirMAP -0.366293870693881 6.98949520701686e-11 NA NA NA hsa-miR-183-5p SOX6 2.08412478942637 1.08931431254487e-10 -1.17584817693337 3.33834806230109e-05 miRNATAP -0.128448512531297 0.014314377159175 NA NA NA hsa-miR-18a-5p SOX6 2.04701000113742 1.30593450319289e-12 -1.17584817693337 3.33834806230109e-05 miRNATAP -0.115074944626234 0.0487887687578343 NA NA NA hsa-miR-21-5p SOX6 2.21515015440792 6.0468197386674e-49 -1.17584817693337 3.33834806230109e-05 MirTarget;miRNATAP -0.453784485718822 2.44036840008645e-06 NA NA NA hsa-miR-1-3p SOX9 -2.73171785118192 3.4424534921136e-12 2.17158899433636 2.83120052041476e-18 MirTarget -0.242264612089594 3.05069298919201e-10 NA NA NA hsa-miR-146b-5p SPAG16 2.23105707690238 3.83997814011313e-23 -1.62434096941706 9.64989096904664e-10 miRanda -0.403148626974549 1.41050153464571e-09 NA NA NA hsa-miR-1-3p SPATA13 -2.73171785118192 3.4424534921136e-12 0.769818160743315 1.58820769365284e-07 MirTarget -0.115005741788193 1.50770713275263e-07 NA NA NA hsa-miR-21-5p SPATA18 2.21515015440792 6.0468197386674e-49 -0.675127017065926 0.00394622208901374 mirMAP -0.202194144413108 0.0115603090628663 NA NA NA hsa-miR-335-3p SPATA18 2.29463721765513 4.1956113745077e-18 -0.675127017065926 0.00394622208901374 MirTarget -0.229512497358002 4.95886095456405e-06 NA NA NA hsa-miR-196b-5p SPATA6 4.51951031652328 7.04026169031626e-18 -0.940166752072841 1.1901088468489e-08 MirTarget -0.100750704589672 2.14189344952747e-08 NA NA NA hsa-miR-146b-5p SPDYA 2.23105707690238 3.83997814011313e-23 -0.505001620026763 4.94727004419592e-06 miRanda -0.202409764466426 3.04997406237808e-14 NA NA NA hsa-miR-21-5p SPDYA 2.21515015440792 6.0468197386674e-49 -0.505001620026763 4.94727004419592e-06 MirTarget -0.170999245247639 5.31934205824535e-06 NA NA NA hsa-miR-146b-5p SPG20 2.23105707690238 3.83997814011313e-23 -1.16044309087638 2.11945718235849e-07 miRanda -0.337214453480229 1.22317532349956e-09 NA NA NA hsa-miR-200b-3p SPG20 2.06025765178663 3.07718049337497e-10 -1.16044309087638 2.11945718235849e-07 TargetScan -0.396748392650767 2.91636381754576e-26 NA NA NA hsa-miR-21-5p SPG20 2.21515015440792 6.0468197386674e-49 -1.16044309087638 2.11945718235849e-07 miRNATAP -0.532828392322181 9.23726090990091e-13 NA NA NA hsa-miR-194-5p SPOCK3 2.24386881692218 9.35116329002209e-11 -2.32057644624764 2.55369634694224e-06 miRNATAP -0.500569382349641 1.68053180267285e-09 NA NA NA hsa-miR-146b-5p SPOP 2.23105707690238 3.83997814011313e-23 -0.419283237917531 1.32584345124033e-05 miRanda -0.170214059746968 2.15916071243529e-13 NA NA NA hsa-miR-335-3p SPOP 2.29463721765513 4.1956113745077e-18 -0.419283237917531 1.32584345124033e-05 MirTarget -0.150079425434539 7.52597231372786e-14 NA NA NA hsa-miR-335-3p SPTSSB 2.29463721765513 4.1956113745077e-18 -2.44045356198944 1.67636366554417e-06 mirMAP -0.248348025864053 0.0274965496124798 NA NA NA hsa-miR-133a-3p SQLE -2.63342156915404 5.72661351480585e-12 0.359731997690427 0.0975929887543778 MirTarget -0.177714182565347 4.84357214038494e-08 NA NA NA hsa-miR-141-5p SREK1IP1 2.13747696823946 1.73124674554872e-11 -0.0164915588201806 0.899208729407544 MirTarget -0.102619588769755 1.42921218382372e-05 NA NA NA hsa-miR-146b-3p SRF 2.08650140817622 5.3293570720033e-22 -0.373426314355344 0.00505633063985255 MirTarget -0.236536450547106 1.56503149703809e-12 NA NA NA hsa-miR-146b-5p SRF 2.23105707690238 3.83997814011313e-23 -0.373426314355344 0.00505633063985255 PITA -0.251616438643061 1.67863759084702e-15 NA NA NA hsa-miR-200a-3p SRF 2.02394729844446 2.21240501925011e-08 -0.373426314355344 0.00505633063985255 miRTarBase -0.218918496517429 1.08016740824401e-28 NA NA NA hsa-miR-200b-3p SRF 2.06025765178663 3.07718049337497e-10 -0.373426314355344 0.00505633063985255 TargetScan -0.235037143254377 3.27007577422506e-27 NA NA NA hsa-miR-935 SRF 2.321600496365 1.00042201726114e-07 -0.373426314355344 0.00505633063985255 PITA;miRNATAP -0.10752538707001 1.0698549798249e-08 NA NA NA hsa-miR-1-3p SRSF1 -2.73171785118192 3.4424534921136e-12 0.463377159053763 3.4862524126175e-10 MirTarget -0.108132991785246 3.45140048844159e-26 NA NA NA hsa-miR-146b-5p SRSF12 2.23105707690238 3.83997814011313e-23 0.0222644906228997 0.935899854565247 miRNATAP -0.229962504150767 0.000806943532228993 NA NA NA hsa-miR-335-3p SRSF12 2.29463721765513 4.1956113745077e-18 0.0222644906228997 0.935899854565247 MirTarget -0.180453266279148 0.00247068703137758 NA NA NA hsa-miR-1-3p SRSF9 -2.73171785118192 3.4424534921136e-12 0.277514024280735 0.00222940642776947 MirTarget -0.102304031967627 1.29986364026474e-15 22178073 In this study we focused on splicing factor serine/arginine-rich 9 SRSF9/SRp30c on the basis of our previous genome-wide gene expression analysis using miR-1-transfected BC cell lines because putative target sites of miR-1 are existed in 3'-untranslated region UTR of SRSF9 mRNA; The expression levels of mRNA of SRSF9 were extremely reduced in the miR-1 transfectants; A luciferase activity significantly decreased in the transfectants suggesting that actual binding occurred between miR-1 and 3'UTR of SRSF9 mRNA; Our data indicated that tumor suppressive miR-1 induces apoptosis through direct inhibition of SRSF9 in BC bladder cancer hsa-miR-146b-5p SSBP2 2.23105707690238 3.83997814011313e-23 -1.58025310656881 5.21464030760244e-12 mirMAP -0.478403102744728 1.38335222005096e-17 NA NA NA hsa-miR-200b-3p SSBP2 2.06025765178663 3.07718049337497e-10 -1.58025310656881 5.21464030760244e-12 mirMAP -0.425786056233421 4.89304747514179e-28 NA NA NA hsa-miR-335-3p SSBP2 2.29463721765513 4.1956113745077e-18 -1.58025310656881 5.21464030760244e-12 MirTarget;mirMAP -0.46795502857872 7.33740928689036e-23 NA NA NA hsa-miR-935 SSBP2 2.321600496365 1.00042201726114e-07 -1.58025310656881 5.21464030760244e-12 MirTarget -0.281239721498857 3.34737282479233e-18 NA NA NA hsa-miR-335-3p SSPN 2.29463721765513 4.1956113745077e-18 -0.581784914650903 0.0246048383030236 mirMAP -0.334199401259086 8.85393039485497e-10 NA NA NA hsa-miR-335-3p SST 2.29463721765513 4.1956113745077e-18 -5.20503558903933 1.03594950971884e-10 MirTarget -0.969694346436847 4.28799057059875e-08 NA NA NA hsa-miR-335-3p ST3GAL1 2.29463721765513 4.1956113745077e-18 0.143656190355653 0.466564155641646 mirMAP -0.114954751273548 0.00689643307998913 NA NA NA hsa-miR-200b-3p ST3GAL2 2.06025765178663 3.07718049337497e-10 0.591994265703637 8.60761825288054e-05 MirTarget;TargetScan -0.143306026062821 9.88437838653042e-08 NA NA NA hsa-miR-200a-3p ST3GAL3 2.02394729844446 2.21240501925011e-08 -0.846525587041888 8.47465785507217e-07 MirTarget;miRNATAP -0.323039569414052 1.38114682646681e-38 NA NA NA hsa-miR-200a-3p ST3GAL5 2.02394729844446 2.21240501925011e-08 -0.581797679124549 0.00104481321112558 MirTarget -0.146156204463897 3.91238458330919e-07 NA NA NA hsa-miR-192-5p ST3GAL6 2.0867723747501 3.57854249239079e-08 -0.515506786199837 0.00194391260076259 miRNAWalker2_validate -0.135789966475308 1.30524303338148e-07 NA NA NA hsa-miR-335-3p ST3GAL6 2.29463721765513 4.1956113745077e-18 -0.515506786199837 0.00194391260076259 MirTarget;mirMAP -0.21952449899221 3.96040538687156e-10 NA NA NA hsa-miR-146b-3p ST5 2.08650140817622 5.3293570720033e-22 -0.77984459959955 5.42103343085045e-09 MirTarget;PITA;miRNATAP -0.267605559320132 3.85220043330544e-15 NA NA NA hsa-miR-146b-5p ST5 2.23105707690238 3.83997814011313e-23 -0.77984459959955 5.42103343085045e-09 miRNATAP -0.274102484903263 1.86166876746057e-17 NA NA NA hsa-miR-135b-5p ST6GAL2 2.80066701698235 2.12546333413447e-11 -1.20067910945844 0.00596959121183519 MirTarget -0.40748852440195 6.53460088723694e-11 NA NA NA hsa-miR-146b-5p ST6GAL2 2.23105707690238 3.83997814011313e-23 -1.20067910945844 0.00596959121183519 miRanda -0.3760509995838 0.000563070785519638 NA NA NA hsa-miR-18a-5p ST6GAL2 2.04701000113742 1.30593450319289e-12 -1.20067910945844 0.00596959121183519 mirMAP -0.630977407979755 1.18755832181353e-13 NA NA NA hsa-miR-200b-3p ST6GAL2 2.06025765178663 3.07718049337497e-10 -1.20067910945844 0.00596959121183519 mirMAP -0.667999183497076 1.43488681143573e-19 NA NA NA hsa-miR-335-3p ST6GAL2 2.29463721765513 4.1956113745077e-18 -1.20067910945844 0.00596959121183519 mirMAP -0.470308304557241 4.6733858593076e-07 NA NA NA hsa-miR-183-5p ST6GALNAC3 2.08412478942637 1.08931431254487e-10 -0.987091626741083 3.89931893571329e-06 MirTarget -0.263054901842482 5.58342071881789e-12 NA NA NA hsa-miR-200a-3p ST6GALNAC3 2.02394729844446 2.21240501925011e-08 -0.987091626741083 3.89931893571329e-06 mirMAP -0.19949341674805 1.03617087976287e-08 NA NA NA hsa-miR-200a-5p ST6GALNAC3 2.19152245759943 3.17968183522514e-11 -0.987091626741083 3.89931893571329e-06 MirTarget -0.203769414334982 7.61881208593972e-08 NA NA NA hsa-miR-200b-3p ST6GALNAC5 2.06025765178663 3.07718049337497e-10 0.0593929043190893 0.834153304191114 TargetScan -0.44867718848151 2.09270591228023e-21 NA NA NA hsa-miR-335-3p ST6GALNAC5 2.29463721765513 4.1956113745077e-18 0.0593929043190893 0.834153304191114 mirMAP -0.247379251090427 4.54202972634123e-05 NA NA NA hsa-miR-335-3p ST8SIA1 2.29463721765513 4.1956113745077e-18 -0.901913462370715 0.0004173816563094 MirTarget -0.419588709027616 2.35390256665036e-15 NA NA NA hsa-miR-200b-3p ST8SIA2 2.06025765178663 3.07718049337497e-10 1.18311729159206 0.0020316431543046 mirMAP -0.388304606679967 1.0865897002612e-08 NA NA NA hsa-miR-935 ST8SIA2 2.321600496365 1.00042201726114e-07 1.18311729159206 0.0020316431543046 mirMAP -0.15950431035164 0.00416187293914501 NA NA NA hsa-miR-135b-5p ST8SIA3 2.80066701698235 2.12546333413447e-11 -2.91558860135036 1.52609950297091e-08 miRNATAP -0.511401001945563 9.55761967829755e-12 NA NA NA hsa-miR-18a-5p ST8SIA3 2.04701000113742 1.30593450319289e-12 -2.91558860135036 1.52609950297091e-08 mirMAP -0.80726913944229 2.43741614898733e-15 NA NA NA hsa-miR-200a-5p ST8SIA3 2.19152245759943 3.17968183522514e-11 -2.91558860135036 1.52609950297091e-08 mirMAP -0.634247751231103 2.64719054972141e-12 NA NA NA hsa-miR-200b-3p ST8SIA3 2.06025765178663 3.07718049337497e-10 -2.91558860135036 1.52609950297091e-08 TargetScan;mirMAP -0.623937282615249 1.2441486038807e-11 NA NA NA hsa-miR-21-5p ST8SIA3 2.21515015440792 6.0468197386674e-49 -2.91558860135036 1.52609950297091e-08 mirMAP -1.18689314970996 8.02444787192825e-12 NA NA NA hsa-miR-335-3p ST8SIA3 2.29463721765513 4.1956113745077e-18 -2.91558860135036 1.52609950297091e-08 mirMAP -0.814808897131696 1.04433947052244e-13 NA NA NA hsa-miR-135b-5p STARD13 2.80066701698235 2.12546333413447e-11 -0.186544413090553 0.273832535954335 MirTarget -0.125137779505262 3.40017151248863e-07 NA NA NA hsa-miR-200b-3p STARD13 2.06025765178663 3.07718049337497e-10 -0.186544413090553 0.273832535954335 TargetScan -0.251061223273788 2.33275856056792e-18 NA NA NA hsa-miR-335-3p STARD13 2.29463721765513 4.1956113745077e-18 -0.186544413090553 0.273832535954335 MirTarget;mirMAP -0.173080861937454 1.77239479721113e-06 NA NA NA hsa-miR-200b-3p STARD8 2.06025765178663 3.07718049337497e-10 -0.142617225960167 0.386273615142595 mirMAP -0.197437513519729 3.90016368282903e-12 NA NA NA hsa-miR-194-5p STAT5B 2.24386881692218 9.35116329002209e-11 -0.181914304812715 0.108203104812812 miRNATAP -0.129573201271531 1.87090128849246e-12 NA NA NA hsa-miR-200a-3p STAT5B 2.02394729844446 2.21240501925011e-08 -0.181914304812715 0.108203104812812 MirTarget;miRNATAP -0.193884317153124 3.12030403766983e-32 NA NA NA hsa-miR-335-3p STAT5B 2.29463721765513 4.1956113745077e-18 -0.181914304812715 0.108203104812812 mirMAP -0.131419608967347 3.60011062463685e-08 NA NA NA hsa-miR-935 STAT5B 2.321600496365 1.00042201726114e-07 -0.181914304812715 0.108203104812812 mirMAP -0.106225075246667 1.27358735139838e-11 NA NA NA hsa-miR-335-3p STEAP4 2.29463721765513 4.1956113745077e-18 -0.609047737827023 0.0429286287495526 mirMAP -0.336733880043302 1.37854383140018e-07 NA NA NA hsa-miR-141-5p STIM1 2.13747696823946 1.73124674554872e-11 -0.671426317532005 1.4294751566811e-10 miRNATAP -0.126029773120295 6.41784865602967e-11 NA NA NA hsa-miR-146b-5p STK32A 2.23105707690238 3.83997814011313e-23 -1.77873554525927 0.000134135047560746 miRanda -0.821176097018769 3.12013356924756e-13 NA NA NA hsa-miR-200a-3p STK32A 2.02394729844446 2.21240501925011e-08 -1.77873554525927 0.000134135047560746 mirMAP -0.544081724511354 2.03751719816426e-13 NA NA NA hsa-miR-335-3p STK32A 2.29463721765513 4.1956113745077e-18 -1.77873554525927 0.000134135047560746 mirMAP -0.585768788495182 3.70392695716833e-09 NA NA NA hsa-miR-183-5p STK33 2.08412478942637 1.08931431254487e-10 -0.92864452301099 0.00657026101364563 miRNAWalker2_validate -0.431959264836519 6.26293851149042e-13 NA NA NA hsa-miR-183-5p STK40 2.08412478942637 1.08931431254487e-10 -0.426530912271271 3.52828839037143e-05 miRNAWalker2_validate -0.108222462361264 4.67344977345167e-09 NA NA NA hsa-miR-18a-5p STK40 2.04701000113742 1.30593450319289e-12 -0.426530912271271 3.52828839037143e-05 mirMAP -0.116907815142507 1.31783303133191e-08 NA NA NA hsa-miR-21-5p STK40 2.21515015440792 6.0468197386674e-49 -0.426530912271271 3.52828839037143e-05 MirTarget;miRNATAP -0.233944693464004 6.18795247437585e-12 NA NA NA hsa-miR-146b-5p STMN2 2.23105707690238 3.83997814011313e-23 -1.82580382670268 0.000431962151942936 miRanda -0.796549769073205 3.34946017713802e-10 NA NA NA hsa-miR-146b-5p STOM 2.23105707690238 3.83997814011313e-23 -0.541925776104607 0.00146422923960109 miRanda -0.220617070699236 1.41437245591439e-07 NA NA NA hsa-miR-146b-3p STOML1 2.08650140817622 5.3293570720033e-22 -0.336657815274886 0.00343186870802586 miRNATAP -0.106451262455117 0.000371559451060665 NA NA NA hsa-miR-192-5p STOX2 2.0867723747501 3.57854249239079e-08 -1.38885793271292 7.68761182671221e-06 miRNAWalker2_validate -0.297829809837207 5.92017630551452e-10 NA NA NA hsa-miR-335-3p STOX2 2.29463721765513 4.1956113745077e-18 -1.38885793271292 7.68761182671221e-06 mirMAP -0.480343451207665 1.96288512664635e-13 NA NA NA hsa-miR-200b-3p STRN3 2.06025765178663 3.07718049337497e-10 -0.14407563641855 0.145314550144892 TargetScan -0.10685916064434 5.08670870550869e-10 NA NA NA hsa-miR-335-3p STS 2.29463721765513 4.1956113745077e-18 -0.45759329958245 0.0189120363811407 mirMAP -0.151624121629433 0.000306768305777882 NA NA NA hsa-miR-18a-5p STX12 2.04701000113742 1.30593450319289e-12 -0.882181299570957 2.03175763589976e-22 miRNAWalker2_validate -0.118484104043417 7.95805486812409e-10 NA NA NA hsa-miR-183-5p STX1B 2.08412478942637 1.08931431254487e-10 -0.0617381495618025 0.781612296881117 mirMAP -0.272918759790504 2.36015717554391e-12 NA NA NA hsa-miR-18a-5p STX1B 2.04701000113742 1.30593450319289e-12 -0.0617381495618025 0.781612296881117 mirMAP -0.205460716780906 3.68635763097195e-06 NA NA NA hsa-miR-200a-3p STX2 2.02394729844446 2.21240501925011e-08 0.23548978769243 0.152150657115843 MirTarget;miRNATAP -0.250419237473856 3.15292941481146e-24 NA NA NA hsa-miR-200a-5p STX2 2.19152245759943 3.17968183522514e-11 0.23548978769243 0.152150657115843 MirTarget -0.267831179272434 1.64960526671385e-23 NA NA NA hsa-miR-200a-3p STXBP1 2.02394729844446 2.21240501925011e-08 0.154311510666179 0.485187424704128 MirTarget;miRNATAP -0.148863064750823 3.2996207340661e-05 NA NA NA hsa-miR-183-5p STXBP4 2.08412478942637 1.08931431254487e-10 0.0813023251686387 0.517318492630089 MirTarget -0.114473701753454 3.05418859866283e-07 NA NA NA hsa-miR-335-3p STXBP5L 2.29463721765513 4.1956113745077e-18 -1.77601007910107 1.66443977510419e-05 mirMAP -0.40418817269126 6.26838286192036e-06 NA NA NA hsa-miR-200b-3p STXBP6 2.06025765178663 3.07718049337497e-10 -0.727299176015706 0.011776569506795 TargetScan -0.149570400110826 0.00414185544386918 NA NA NA hsa-miR-200b-3p SULF1 2.06025765178663 3.07718049337497e-10 2.66492104637834 5.21304611366659e-20 MirTarget;TargetScan -0.138332768869932 0.0144696325136573 NA NA NA hsa-miR-146b-5p SULT1C4 2.23105707690238 3.83997814011313e-23 -0.262795981185597 0.346543999017258 miRanda -0.339056940366489 7.19159144117509e-07 NA NA NA hsa-miR-335-3p SUN2 2.29463721765513 4.1956113745077e-18 -0.509272372447409 1.18153318171823e-06 mirMAP -0.133176774621137 2.74242075618304e-09 NA NA NA hsa-miR-1-3p SUSD1 -2.73171785118192 3.4424534921136e-12 0.620450212856225 8.0858243819331e-06 MirTarget -0.107517915003742 1.75458838544165e-07 NA NA NA hsa-miR-335-3p SUSD5 2.29463721765513 4.1956113745077e-18 -0.46107369464989 0.149339017265512 mirMAP -0.411875484855722 8.82934900802017e-10 NA NA NA hsa-miR-200a-3p SV2B 2.02394729844446 2.21240501925011e-08 -0.292959637600184 0.363390606978728 MirTarget -0.390861322528773 7.54518300489291e-15 NA NA NA hsa-miR-200b-3p SV2B 2.06025765178663 3.07718049337497e-10 -0.292959637600184 0.363390606978728 mirMAP -0.417305945557213 4.8224896189816e-14 NA NA NA hsa-miR-21-5p SV2B 2.21515015440792 6.0468197386674e-49 -0.292959637600184 0.363390606978728 mirMAP -0.346354591106876 0.00149865112071962 NA NA NA hsa-miR-935 SVEP1 2.321600496365 1.00042201726114e-07 -0.71208635341524 0.0147541038616657 miRNATAP -0.209670780769685 4.52053243997623e-07 NA NA NA hsa-miR-146b-5p SVIL 2.23105707690238 3.83997814011313e-23 -0.769171690196438 0.00559842260659146 PITA;miRanda -0.527529205790239 1.35163946311801e-15 NA NA NA hsa-miR-200a-3p SVIL 2.02394729844446 2.21240501925011e-08 -0.769171690196438 0.00559842260659146 miRNATAP -0.554305456777274 1.3721720264989e-47 NA NA NA hsa-miR-335-3p SVIL 2.29463721765513 4.1956113745077e-18 -0.769171690196438 0.00559842260659146 mirMAP -0.384153074618878 4.49984779559257e-11 NA NA NA hsa-miR-335-3p SWAP70 2.29463721765513 4.1956113745077e-18 -0.0283444386061209 0.810845764431306 MirTarget -0.131479642587985 1.37808722933083e-07 NA NA NA hsa-miR-146b-5p SYCE1 2.23105707690238 3.83997814011313e-23 -0.657383559625726 0.0660291305413517 miRanda -0.292490259303477 0.00101711843389179 NA NA NA hsa-miR-146b-5p SYDE1 2.23105707690238 3.83997814011313e-23 -0.0640700013959519 0.734826242563291 miRanda -0.222319386612557 1.60201393373565e-06 NA NA NA hsa-miR-200b-3p SYDE1 2.06025765178663 3.07718049337497e-10 -0.0640700013959519 0.734826242563291 MirTarget;TargetScan -0.362658958637974 8.6322888920495e-34 NA NA NA hsa-miR-146b-5p SYN2 2.23105707690238 3.83997814011313e-23 -1.95826288584871 5.14073671926729e-05 miRanda -0.77437882910728 5.89238050882173e-11 NA NA NA hsa-miR-200b-3p SYNC 2.06025765178663 3.07718049337497e-10 -0.049400498576218 0.684649529452626 MirTarget -0.162538097621052 4.14693571419122e-15 NA NA NA hsa-miR-335-3p SYNE1 2.29463721765513 4.1956113745077e-18 -0.737828565382011 0.00316151426540844 mirMAP -0.428569620957755 6.52190510643788e-17 NA NA NA hsa-miR-18a-5p SYNM 2.04701000113742 1.30593450319289e-12 -2.30903358719501 8.60321297446932e-06 MirTarget -1.13176356085279 4.65910929679885e-33 NA NA NA hsa-miR-146b-5p SYNPO2 2.23105707690238 3.83997814011313e-23 -2.34174021707755 2.03811728353031e-06 miRanda -0.926625415138219 8.27256727429305e-15 NA NA NA hsa-miR-200a-3p SYNPO2 2.02394729844446 2.21240501925011e-08 -2.34174021707755 2.03811728353031e-06 miRNATAP -0.913163688051562 4.36937077961547e-37 NA NA NA hsa-miR-200a-5p SYNPO2 2.19152245759943 3.17968183522514e-11 -2.34174021707755 2.03811728353031e-06 mirMAP -0.976642388033826 8.03876017708939e-36 NA NA NA hsa-miR-200b-3p SYNPO2 2.06025765178663 3.07718049337497e-10 -2.34174021707755 2.03811728353031e-06 mirMAP -0.968116581736732 6.92972720371986e-34 NA NA NA hsa-miR-335-3p SYNPO2 2.29463721765513 4.1956113745077e-18 -2.34174021707755 2.03811728353031e-06 mirMAP -0.964699427305175 8.27945036932412e-22 NA NA NA hsa-miR-146b-5p SYNPR 2.23105707690238 3.83997814011313e-23 -0.683844873517568 0.252113050117667 miRanda -0.44538054678151 0.00273467812564483 NA NA NA hsa-miR-146b-5p SYPL2 2.23105707690238 3.83997814011313e-23 -0.878066131192998 0.00351395714730577 miRanda -0.551415224973522 1.79304034061416e-14 NA NA NA hsa-miR-146b-5p SYT1 2.23105707690238 3.83997814011313e-23 -0.131809945129705 0.773109960771398 MirTarget;PITA;miRanda;miRNATAP -0.577421772620989 2.40007435700683e-07 NA NA NA hsa-miR-183-5p SYT1 2.08412478942637 1.08931431254487e-10 -0.131809945129705 0.773109960771398 miRNATAP -0.449764261243633 3.27764720806331e-08 NA NA NA hsa-miR-200b-3p SYT1 2.06025765178663 3.07718049337497e-10 -0.131809945129705 0.773109960771398 MirTarget;TargetScan -0.445400906687112 3.06992235440953e-08 NA NA NA hsa-miR-335-3p SYT1 2.29463721765513 4.1956113745077e-18 -0.131809945129705 0.773109960771398 mirMAP -0.294545736357753 0.00279792578158996 NA NA NA hsa-miR-146b-5p SYT11 2.23105707690238 3.83997814011313e-23 -0.0332651006696336 0.879791327587014 miRanda -0.202591086891622 0.000194376246144283 NA NA NA hsa-miR-200b-3p SYT11 2.06025765178663 3.07718049337497e-10 -0.0332651006696336 0.879791327587014 mirMAP -0.377175282707284 9.70715965878904e-26 NA NA NA hsa-miR-18a-5p SYT15 2.04701000113742 1.30593450319289e-12 -1.31160460302584 2.58607335214078e-06 MirTarget -0.529379786388855 1.27049925639822e-23 NA NA NA hsa-miR-21-5p SYT15 2.21515015440792 6.0468197386674e-49 -1.31160460302584 2.58607335214078e-06 MirTarget -0.572943042212295 1.04490624639451e-09 NA NA NA hsa-miR-200a-3p SYT2 2.02394729844446 2.21240501925011e-08 -0.0440682435334239 0.850057826884027 mirMAP -0.13232600293563 0.000493472615028639 NA NA NA hsa-miR-935 SYT2 2.321600496365 1.00042201726114e-07 -0.0440682435334239 0.850057826884027 mirMAP -0.137850088586837 3.34197541284236e-05 NA NA NA hsa-miR-135b-5p SYT3 2.80066701698235 2.12546333413447e-11 0.198584605183963 0.586926830034396 MirTarget -0.147824037340596 0.00580862721816705 NA NA NA hsa-miR-200a-3p SYT4 2.02394729844446 2.21240501925011e-08 -3.20681967154073 1.00295168545729e-07 MirTarget;miRNATAP -0.64842275794056 3.49886318362838e-11 NA NA NA hsa-miR-335-3p SYT4 2.29463721765513 4.1956113745077e-18 -3.20681967154073 1.00295168545729e-07 MirTarget;mirMAP -0.85307628544942 3.76779603016985e-11 NA NA NA hsa-miR-18a-5p SYT5 2.04701000113742 1.30593450319289e-12 -1.08934143126598 0.0106813679333352 mirMAP -0.185399646930838 0.033167287781547 NA NA NA hsa-miR-92a-1-5p SYT5 2.04820501765632 9.32117486799495e-13 -1.08934143126598 0.0106813679333352 MirTarget -0.209691302084251 0.0186455863025556 NA NA NA hsa-miR-146b-5p SYT9 2.23105707690238 3.83997814011313e-23 -1.2424741563645 0.001403286587921 miRanda -0.555335001301506 5.78310497081047e-09 NA NA NA hsa-miR-192-5p SYT9 2.0867723747501 3.57854249239079e-08 -1.2424741563645 0.001403286587921 mirMAP -0.321990481486296 9.20535991521678e-08 NA NA NA hsa-miR-196a-5p SYT9 5.05945965885472 4.48343841468539e-25 -1.2424741563645 0.001403286587921 miRNAWalker2_validate;MirTarget;miRNATAP -0.234504805978341 1.18827257418339e-07 NA NA NA hsa-miR-196b-5p SYT9 4.51951031652328 7.04026169031626e-18 -1.2424741563645 0.001403286587921 MirTarget -0.225117884880582 6.90610585240156e-08 NA NA NA hsa-miR-141-5p SYTL4 2.13747696823946 1.73124674554872e-11 -0.526634563646359 0.000254509035113517 mirMAP -0.100465602501781 0.000160588165112837 NA NA NA hsa-miR-146b-5p SYTL4 2.23105707690238 3.83997814011313e-23 -0.526634563646359 0.000254509035113517 miRanda -0.117616681325508 0.00111521110232415 NA NA NA hsa-miR-146b-5p TAB2 2.23105707690238 3.83997814011313e-23 -0.426442292317995 3.03594178765346e-06 miRanda -0.136044277118464 1.25327695248495e-09 NA NA NA hsa-miR-335-3p TAB2 2.29463721765513 4.1956113745077e-18 -0.426442292317995 3.03594178765346e-06 mirMAP -0.113746875011856 5.1360929868708e-09 NA NA NA hsa-miR-200a-3p TAC1 2.02394729844446 2.21240501925011e-08 -2.61033448142217 7.69833927608617e-05 MirTarget -0.929019511089096 1.18595461791268e-19 NA NA NA hsa-miR-141-5p TACC1 2.13747696823946 1.73124674554872e-11 -0.361657767484704 0.0540556103390073 MirTarget -0.344191128617408 3.10146080009826e-28 NA NA NA hsa-miR-146b-3p TACC1 2.08650140817622 5.3293570720033e-22 -0.361657767484704 0.0540556103390073 MirTarget;miRNATAP -0.269068781620918 1.9158409266714e-08 NA NA NA hsa-miR-146b-5p TACR1 2.23105707690238 3.83997814011313e-23 -1.93191918033095 1.22360433438258e-06 miRanda -0.589725797139534 2.28799991746245e-09 NA NA NA hsa-miR-146b-5p TAF9B 2.23105707690238 3.83997814011313e-23 -0.215431801968458 0.0920309395574713 miRNATAP -0.205852544794928 1.99224279251248e-11 NA NA NA hsa-miR-192-5p TAF9B 2.0867723747501 3.57854249239079e-08 -0.215431801968458 0.0920309395574713 miRNAWalker2_validate -0.174513080596497 5.10925335435812e-21 NA NA NA hsa-miR-135b-5p TAGAP 2.80066701698235 2.12546333413447e-11 -0.464489368917201 0.0678164346276331 MirTarget -0.1599616856805 1.52664828798244e-05 NA NA NA hsa-miR-335-3p TAGAP 2.29463721765513 4.1956113745077e-18 -0.464489368917201 0.0678164346276331 MirTarget -0.215506440043919 7.92188147357272e-05 NA NA NA hsa-miR-141-5p TAL1 2.13747696823946 1.73124674554872e-11 -0.4621379663598 0.00573995025552282 MirTarget -0.224468384392927 3.19203835565066e-14 NA NA NA hsa-miR-335-3p TAL1 2.29463721765513 4.1956113745077e-18 -0.4621379663598 0.00573995025552282 mirMAP -0.212249282183605 1.87382209587706e-09 NA NA NA hsa-miR-146b-5p TANC2 2.23105707690238 3.83997814011313e-23 0.42757803384238 0.0387144616281218 PITA;miRanda;mirMAP;miRNATAP -0.104348657713469 0.0439715033090312 NA NA NA hsa-miR-335-3p TANC2 2.29463721765513 4.1956113745077e-18 0.42757803384238 0.0387144616281218 mirMAP -0.111149561469188 0.0131355682833115 NA NA NA hsa-miR-200a-3p TBC1D1 2.02394729844446 2.21240501925011e-08 -0.109680789296321 0.450608079624706 MirTarget -0.219229937753648 8.28260979699723e-24 NA NA NA hsa-miR-200b-3p TBC1D25 2.06025765178663 3.07718049337497e-10 -0.338626637083983 2.44818926988778e-05 mirMAP -0.102099883089903 2.07797741780275e-13 NA NA NA hsa-miR-335-3p TBC1D9 2.29463721765513 4.1956113745077e-18 -0.414777002478332 0.010474537206971 MirTarget -0.189465479131526 3.48861393954174e-08 NA NA NA hsa-miR-935 TBC1D9 2.321600496365 1.00042201726114e-07 -0.414777002478332 0.010474537206971 PITA;miRNATAP -0.113856824141355 7.83077417222487e-07 NA NA NA hsa-miR-200b-3p TBCEL 2.06025765178663 3.07718049337497e-10 -0.400003822040212 0.0189360861907399 TargetScan -0.194588443645355 6.03451290512809e-11 NA NA NA hsa-miR-183-5p TBKBP1 2.08412478942637 1.08931431254487e-10 -0.454084858927937 0.0171395364821397 MirTarget -0.23634185478789 1.55086696630226e-12 NA NA NA hsa-miR-192-5p TBL1X 2.0867723747501 3.57854249239079e-08 -0.252702013629877 0.178914931206428 miRNAWalker2_validate -0.210131363753877 8.16390693657987e-14 NA NA NA hsa-miR-141-5p TBX18 2.13747696823946 1.73124674554872e-11 0.842853893697507 0.0294523641916109 MirTarget;miRNATAP -0.406200569020979 6.21575631757029e-09 NA NA NA hsa-miR-200b-3p TBX18 2.06025765178663 3.07718049337497e-10 0.842853893697507 0.0294523641916109 MirTarget -0.457646624088205 1.1390313152526e-11 NA NA NA hsa-miR-200b-3p TBX5 2.06025765178663 3.07718049337497e-10 0.960968095527673 0.10661691842954 TargetScan -0.246857912942069 0.0217606332629862 NA NA NA hsa-miR-18a-5p TCEA2 2.04701000113742 1.30593450319289e-12 -0.653060587847677 0.00171167383430329 miRNAWalker2_validate -0.247641417809946 2.05533988786389e-09 NA NA NA hsa-miR-335-3p TCEAL1 2.29463721765513 4.1956113745077e-18 -0.827139818422962 1.02278366667162e-06 MirTarget -0.20368334382881 2.3039662934358e-08 NA NA NA hsa-miR-194-5p TCEAL4 2.24386881692218 9.35116329002209e-11 -0.412999624410539 0.0118262508268025 MirTarget -0.223150218136694 2.02042963652152e-17 NA NA NA hsa-miR-146b-5p TCF21 2.23105707690238 3.83997814011313e-23 -1.32513315450316 2.22849997566556e-08 miRanda -0.304902956098613 3.15749403641426e-07 NA NA NA hsa-miR-21-5p TCF21 2.21515015440792 6.0468197386674e-49 -1.32513315450316 2.22849997566556e-08 miRNAWalker2_validate -0.552529711637857 3.81809759900787e-12 NA NA NA hsa-miR-183-5p TCF4 2.08412478942637 1.08931431254487e-10 0.0159386247034305 0.922706223016712 miRNATAP -0.246563285534344 1.07016411452997e-18 NA NA NA hsa-miR-200a-3p TCF4 2.02394729844446 2.21240501925011e-08 0.0159386247034305 0.922706223016712 MirTarget;miRNATAP -0.214552238153501 2.14081422312e-17 NA NA NA hsa-miR-200a-5p TCF4 2.19152245759943 3.17968183522514e-11 0.0159386247034305 0.922706223016712 mirMAP;miRNATAP -0.221293473189685 1.06188081133671e-15 NA NA NA hsa-miR-200b-3p TCF4 2.06025765178663 3.07718049337497e-10 0.0159386247034305 0.922706223016712 TargetScan;mirMAP -0.225255072605693 7.35257467511235e-16 NA NA NA hsa-miR-200a-3p TCF7L1 2.02394729844446 2.21240501925011e-08 -0.950810170611323 2.06235136278501e-05 miRNAWalker2_validate -0.405182514690993 1.2373922056801e-35 NA NA NA hsa-miR-200b-3p TCF7L1 2.06025765178663 3.07718049337497e-10 -0.950810170611323 2.06235136278501e-05 miRNAWalker2_validate -0.442824188097337 3.15038718766065e-35 NA NA NA hsa-miR-200b-3p TCP11L1 2.06025765178663 3.07718049337497e-10 -0.105536830873831 0.359236205501265 MirTarget -0.199133711821535 1.80870675624935e-26 NA NA NA hsa-miR-146b-5p TCP11L2 2.23105707690238 3.83997814011313e-23 -0.703043045809048 5.15797474593356e-05 miRanda -0.168214714866054 0.00011064275161928 NA NA NA hsa-miR-194-5p TDRD9 2.24386881692218 9.35116329002209e-11 -0.577324414665104 0.0903786137422783 MirTarget -0.126241220232257 0.0296744513336203 NA NA NA hsa-miR-146b-5p TEAD1 2.23105707690238 3.83997814011313e-23 -0.180963993433754 0.334001704599182 PITA;miRanda -0.281187162507054 5.18307802870591e-10 NA NA NA hsa-miR-192-5p TEAD1 2.0867723747501 3.57854249239079e-08 -0.180963993433754 0.334001704599182 mirMAP -0.277123669862145 3.54190497684551e-25 NA NA NA hsa-miR-194-5p TEAD1 2.24386881692218 9.35116329002209e-11 -0.180963993433754 0.334001704599182 MirTarget -0.267983955514845 1.38349291765755e-19 NA NA NA hsa-miR-200a-3p TEAD1 2.02394729844446 2.21240501925011e-08 -0.180963993433754 0.334001704599182 mirMAP -0.316364289834961 5.21859333159261e-31 NA NA NA hsa-miR-200a-5p TEAD1 2.19152245759943 3.17968183522514e-11 -0.180963993433754 0.334001704599182 miRNATAP -0.331810456264874 1.25200058035814e-28 NA NA NA hsa-miR-200b-3p TEAD1 2.06025765178663 3.07718049337497e-10 -0.180963993433754 0.334001704599182 TargetScan -0.32760980527879 6.12847459243077e-27 NA NA NA hsa-miR-335-3p TEAD1 2.29463721765513 4.1956113745077e-18 -0.180963993433754 0.334001704599182 MirTarget -0.182297212874616 4.86434041506353e-06 NA NA NA hsa-miR-935 TEAD1 2.321600496365 1.00042201726114e-07 -0.180963993433754 0.334001704599182 mirMAP -0.14024238231147 1.11897735434571e-07 NA NA NA hsa-miR-146b-5p TEAD3 2.23105707690238 3.83997814011313e-23 -0.295819701704168 0.0405575089332212 miRanda -0.279355407111432 2.28827818388197e-16 NA NA NA hsa-miR-146b-3p TEF 2.08650140817622 5.3293570720033e-22 -1.31793622768117 7.07945757731098e-14 PITA -0.412340766537993 4.18174134648039e-20 NA NA NA hsa-miR-196a-5p TEF 5.05945965885472 4.48343841468539e-25 -1.31793622768117 7.07945757731098e-14 mirMAP -0.17617002248079 9.84460716346504e-19 NA NA NA hsa-miR-196b-5p TEF 4.51951031652328 7.04026169031626e-18 -1.31793622768117 7.07945757731098e-14 mirMAP -0.141339869417479 1.95250403763207e-13 NA NA NA hsa-miR-146b-5p TES 2.23105707690238 3.83997814011313e-23 -0.348224082593956 0.00638545187280882 miRanda -0.167235672389867 8.75714870778442e-08 NA NA NA hsa-miR-200b-3p TES 2.06025765178663 3.07718049337497e-10 -0.348224082593956 0.00638545187280882 MirTarget -0.156583048219473 1.47873847600946e-12 NA NA NA hsa-miR-21-5p TESK2 2.21515015440792 6.0468197386674e-49 -0.789206095132177 9.25451549840534e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.218555409375617 4.50003818642008e-08 NA NA NA hsa-miR-335-3p TESPA1 2.29463721765513 4.1956113745077e-18 -0.579214572083235 0.033511866894764 mirMAP -0.258693302838956 9.24246751983152e-06 NA NA NA hsa-miR-183-5p TET1 2.08412478942637 1.08931431254487e-10 -0.135207146556726 0.521377501429362 MirTarget;miRNATAP -0.18669522330754 7.41675729108368e-07 NA NA NA hsa-miR-200a-3p TET1 2.02394729844446 2.21240501925011e-08 -0.135207146556726 0.521377501429362 MirTarget -0.220862524518416 3.53154972712834e-11 NA NA NA hsa-miR-135b-5p TFDP2 2.80066701698235 2.12546333413447e-11 -0.160784627018407 0.291450213121909 mirMAP -0.134937816730586 4.69084955548852e-10 NA NA NA hsa-miR-146b-5p TFDP2 2.23105707690238 3.83997814011313e-23 -0.160784627018407 0.291450213121909 MirTarget -0.203833158960925 3.85330635310907e-08 NA NA NA hsa-miR-200a-3p TFDP2 2.02394729844446 2.21240501925011e-08 -0.160784627018407 0.291450213121909 MirTarget -0.172157284299519 6.00295058912596e-13 NA NA NA hsa-miR-200b-3p TFE3 2.06025765178663 3.07718049337497e-10 -0.148694225848911 0.0945753933836065 MirTarget -0.126095455366964 3.98887215412274e-17 NA NA NA hsa-miR-200b-3p TFPI 2.06025765178663 3.07718049337497e-10 -0.0903165752589947 0.661792991177754 MirTarget -0.147658216274263 5.95047539744533e-05 NA NA NA hsa-miR-335-3p TFPI 2.29463721765513 4.1956113745077e-18 -0.0903165752589947 0.661792991177754 mirMAP -0.103708941409127 0.0200417160784398 NA NA NA hsa-miR-200a-3p TGFB2 2.02394729844446 2.21240501925011e-08 0.888965225928418 0.000136671877757956 MirTarget;miRNATAP -0.189993396216634 5.87055843170913e-07 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-146b-5p TGFBR1 2.23105707690238 3.83997814011313e-23 0.314960081526936 0.0242756626193909 miRanda -0.100586823977199 0.00387900619732714 NA NA NA hsa-miR-200b-3p TGFBR1 2.06025765178663 3.07718049337497e-10 0.314960081526936 0.0242756626193909 mirMAP -0.152860041835442 3.98493123010757e-10 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-18a-5p TGFBR2 2.04701000113742 1.30593450319289e-12 -0.243315633013612 0.114081643080486 miRNAWalker2_validate -0.209546376706227 2.56963197608545e-12 NA NA NA hsa-miR-335-3p TGFBR2 2.29463721765513 4.1956113745077e-18 -0.243315633013612 0.114081643080486 mirMAP -0.13908461324797 2.36022251288756e-05 NA NA NA hsa-miR-18a-5p TGFBR3 2.04701000113742 1.30593450319289e-12 -1.17329353105567 5.76332601597347e-06 MirTarget -0.463837870869312 6.92563089817596e-21 NA NA NA hsa-miR-21-5p TGFBR3 2.21515015440792 6.0468197386674e-49 -1.17329353105567 5.76332601597347e-06 miRNAWalker2_validate -0.58929783986775 7.9673565096856e-12 NA NA NA hsa-miR-335-3p TGFBR3 2.29463721765513 4.1956113745077e-18 -1.17329353105567 5.76332601597347e-06 mirMAP -0.366707155842899 2.48867767277997e-11 NA NA NA hsa-miR-146b-5p THAP10 2.23105707690238 3.83997814011313e-23 -0.162923309580666 0.311050432193818 miRanda -0.16105294646635 4.85130209930813e-05 NA NA NA hsa-miR-146b-3p THAP2 2.08650140817622 5.3293570720033e-22 -0.44333727061979 0.000346316863159667 miRNATAP -0.175380693829292 3.584721916624e-08 NA NA NA hsa-miR-200b-3p THAP2 2.06025765178663 3.07718049337497e-10 -0.44333727061979 0.000346316863159667 MirTarget -0.155156078834538 5.90231899372329e-13 NA NA NA hsa-miR-192-5p THBD 2.0867723747501 3.57854249239079e-08 -0.791451046098264 5.07141412103183e-05 miRNAWalker2_validate -0.192372195439883 1.53383572386925e-10 NA NA NA hsa-miR-18a-5p THBS1 2.04701000113742 1.30593450319289e-12 0.740672313122665 0.00386405601476247 MirTarget -0.249337071803029 1.24104410872786e-06 NA NA NA hsa-miR-200a-5p THBS1 2.19152245759943 3.17968183522514e-11 0.740672313122665 0.00386405601476247 MirTarget -0.283869686404899 1.6588159525732e-10 NA NA NA hsa-miR-335-3p THBS1 2.29463721765513 4.1956113745077e-18 0.740672313122665 0.00386405601476247 mirMAP -0.116746872361894 0.0367223970639482 NA NA NA hsa-miR-133a-3p THNSL1 -2.63342156915404 5.72661351480585e-12 0.791220503277007 4.91481742310103e-08 MirTarget -0.123554810893646 2.81589544810659e-08 NA NA NA hsa-miR-146b-3p THRA 2.08650140817622 5.3293570720033e-22 -0.307072921703847 0.0509872192086203 PITA;miRNATAP -0.163560035308069 5.81265874648071e-05 NA NA NA hsa-miR-135b-5p THRB 2.80066701698235 2.12546333413447e-11 -1.11745660181354 0.00039648730743052 MirTarget -0.250413445645502 4.58720757414678e-08 NA NA NA hsa-miR-141-5p THRB 2.13747696823946 1.73124674554872e-11 -1.11745660181354 0.00039648730743052 MirTarget -0.333834101610278 5.91021765023499e-09 NA NA NA hsa-miR-146b-3p THRB 2.08650140817622 5.3293570720033e-22 -1.11745660181354 0.00039648730743052 miRNATAP -0.489145091612698 1.45013428133036e-09 NA NA NA hsa-miR-146b-5p THRB 2.23105707690238 3.83997814011313e-23 -1.11745660181354 0.00039648730743052 MirTarget;miRanda -0.508331863889056 3.57258046972119e-11 NA NA NA hsa-miR-18a-5p THRB 2.04701000113742 1.30593450319289e-12 -1.11745660181354 0.00039648730743052 MirTarget -0.355290397169314 1.75515942245683e-08 NA NA NA hsa-miR-200a-3p THRB 2.02394729844446 2.21240501925011e-08 -1.11745660181354 0.00039648730743052 MirTarget;miRNATAP -0.317175908018683 4.06665492096359e-10 NA NA NA hsa-miR-200b-3p THRB 2.06025765178663 3.07718049337497e-10 -1.11745660181354 0.00039648730743052 TargetScan;mirMAP -0.365906730083304 4.19911057757576e-11 NA NA NA hsa-miR-21-5p THRB 2.21515015440792 6.0468197386674e-49 -1.11745660181354 0.00039648730743052 MirTarget;miRNATAP -0.553748065490499 1.85885605968371e-07 21159845 Direct interaction with THRB was shown for miR-21 and miR-146a; We observed lower levels of THRB transcripts in cell lines transfected with miR-21 -146a and -221 down-regulation of 37-48%; P < 0.0001 but not with miR-181a; The analysis of tumor/normal tissue pairs revealed down-regulation of THRB in 11 of 13 pairs 1.3- to 9.1-fold and up-regulation of miR-21 -146a -181a and -221 in almost all pairs thyroid cancer hsa-miR-335-3p THRB 2.29463721765513 4.1956113745077e-18 -1.11745660181354 0.00039648730743052 MirTarget;mirMAP -0.296949080532039 1.30464127507598e-05 NA NA NA hsa-miR-200a-3p THSD4 2.02394729844446 2.21240501925011e-08 -1.40005104343222 1.03135805453461e-07 MirTarget -0.18461740015179 2.49543627215619e-05 NA NA NA hsa-miR-335-3p THSD4 2.29463721765513 4.1956113745077e-18 -1.40005104343222 1.03135805453461e-07 MirTarget;mirMAP -0.248069208374669 1.69563444906081e-05 NA NA NA hsa-miR-92a-1-5p THSD4 2.04820501765632 9.32117486799495e-13 -1.40005104343222 1.03135805453461e-07 mirMAP -0.33114249015307 1.16975841487673e-09 NA NA NA hsa-miR-200b-3p THSD7A 2.06025765178663 3.07718049337497e-10 0.242279573672174 0.251540034596406 TargetScan -0.272474534273393 6.06531100434947e-14 NA NA NA hsa-miR-146b-5p THSD7B 2.23105707690238 3.83997814011313e-23 0.153550486425183 0.747226234222489 miRanda -0.468696040343307 6.81901558193192e-05 NA NA NA hsa-miR-183-5p THSD7B 2.08412478942637 1.08931431254487e-10 0.153550486425183 0.747226234222489 miRNATAP -0.66412891900322 6.17235453673321e-16 NA NA NA hsa-miR-135b-5p TIAM1 2.80066701698235 2.12546333413447e-11 -0.741051913482461 0.00185201928858849 MirTarget -0.192288059074304 2.30422846945786e-08 NA NA NA hsa-miR-183-5p TIAM1 2.08412478942637 1.08931431254487e-10 -0.741051913482461 0.00185201928858849 miRNATAP -0.181150080242602 2.80991887550687e-05 NA NA NA hsa-miR-200a-3p TIAM1 2.02394729844446 2.21240501925011e-08 -0.741051913482461 0.00185201928858849 MirTarget;miRNATAP -0.146252715888807 0.000181670112272292 NA NA NA hsa-miR-21-5p TIAM1 2.21515015440792 6.0468197386674e-49 -0.741051913482461 0.00185201928858849 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.291116901444628 0.000324644941290984 20826792 miR 21 and miR 31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells; We present compelling evidence that TIAM1 a guanidine exchange factor of the Rac GTPase is a direct target of both miR-21 and miR-31 colon cancer hsa-miR-335-3p TIAM1 2.29463721765513 4.1956113745077e-18 -0.741051913482461 0.00185201928858849 MirTarget -0.155149470024204 0.00270457425412046 NA NA NA hsa-miR-200b-3p TIMP2 2.06025765178663 3.07718049337497e-10 -0.112188449077383 0.558631566061868 TargetScan -0.339861164647159 8.22085239291579e-28 23205572 A novel target of miR-200b tissue inhibitor of metalloproteinase 2 TIMP2 was predicted using a bioinformatics approach and was confirmed in human endometrial cancer cell line HEC-1A cells by luciferase assay quantitative real-time polymerase chain reaction western blotting and enzyme-linked immunosorbent assay; We found that miR-200b repressed TIMP2 expression at both the messenger RNA and protein levels although a family member miR-200a had no such effect; Using reverse gelatin zymography we showed that miR-200b enhances matrix metallopeptidase 2 MMP2 activity by downregulating TIMP2 expression in HEC-1A cells endometrial cancer hsa-miR-21-5p TIMP3 2.21515015440792 6.0468197386674e-49 -0.545766258963537 0.0230696906023966 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.34367964487154 2.19174550707526e-05 23936642;21820586;25720799;20346171;25587717 Genetic heterogeneity of breast cancer metastasis may be related to miR 21 regulation of TIMP 3 in translation; The aim of this study is to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis promoted breast cancer metastasis by regulating the tissue inhibitor of metalloproteinase 3 TIMP-3 gene; Correlation analysis was performed between miR-21 and TIMP-3; There was significantly inverse correlation between miR-21 and TIMP-3 extracted from tissue;The effect of TIMP3 on miR-21-induced cell survival was determined by transfection with TIMP3 lacking 3' untranslated region and miR-21;We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase MMP inhibitors RECK and TIMP3 which are known to impact HCC progression and metastases; Finally we found that inhibition of miR-21 in murine HMGB1-overexpressing HCC xenografts led to reduced tumor MMP activity through released repression of the miR-21 targets RECK and TIMP3 which ultimately impeded tumor progression;The aim of this study was to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis impacts breast cancer invasion by regulating the tissue inhibitor of metalloproteinase 3 TIMP3 gene; In addition the regulation of tissue inhibitor of metalloproteinase 3 TIMP3 by miR-21 was evaluated by western blotting and luciferase assays; Evaluation of TIMP3 protein levels a peptidase involved in extarcellular matrix degredation inversely correlated with miR-21 expression; As knockdown of miR-21 increased TIMP3 protein expression and luciferase reporter activity our data suggests that miR-21 could promote invasion in breast cancer cells via its regulation of TIMP3;It was previously shown by our group that miR-21 a potential regulator of TIMP3 is over-expressed in cutaneous melanoma; It was therefore hypothesized that increased levels of miR-21 expression would lead to decreased expression of TIMP3 and thereby enhance the invasiveness of melanoma cells; Reduced expression of TIMP3 was achieved by siRNA knockdown and significantly enhanced invasion of melanoma cell lines mimicking the effects of miR-21 over-expression; Treatment of tumor cells with a linked nucleic acid antagomir to miR-21 inhibited tumor growth and increased tumor expression of TIMP3 in vivo in 01B74 Athymic NCr-nu/nu mice; This data shows that increased expression of miR-21 enhanced the invasive potential of melanoma cell lines through TIMP3 inhibition metastasis;tumorigenesis;poor survival;metastasis;progression;tumorigenesis; breast cancer;kidney renal cell cancer;liver cancer;breast cancer;melanoma hsa-miR-146b-5p TIMP4 2.23105707690238 3.83997814011313e-23 -1.49704285880667 7.33033358502136e-05 miRanda;miRNATAP -0.541002159668751 6.08525689013643e-09 NA NA NA hsa-miR-146b-5p TJP1 2.23105707690238 3.83997814011313e-23 -0.131938594922226 0.315131821076645 miRanda -0.139644631897158 1.50121622809163e-05 NA NA NA hsa-miR-194-5p TJP1 2.24386881692218 9.35116329002209e-11 -0.131938594922226 0.315131821076645 miRNATAP -0.13107780314242 1.2630024948761e-09 NA NA NA hsa-miR-200b-3p TJP1 2.06025765178663 3.07718049337497e-10 -0.131938594922226 0.315131821076645 TargetScan -0.105051726159028 6.31057595486219e-06 NA NA NA hsa-miR-146b-5p TLE4 2.23105707690238 3.83997814011313e-23 -1.15702818127241 1.2267818242402e-11 miRanda -0.267064870462388 5.28702080615066e-10 NA NA NA hsa-miR-146b-5p TLN1 2.23105707690238 3.83997814011313e-23 -0.287038594162333 0.0813060668186822 miRanda -0.239335694272638 2.06361195875347e-09 NA NA NA hsa-miR-200b-3p TLN1 2.06025765178663 3.07718049337497e-10 -0.287038594162333 0.0813060668186822 TargetScan -0.329488776067562 1.50804597491702e-37 NA NA NA hsa-miR-92a-1-5p TLN1 2.04820501765632 9.32117486799495e-13 -0.287038594162333 0.0813060668186822 MirTarget -0.201394065965405 1.33910082279646e-09 NA NA NA hsa-miR-335-3p TLR10 2.29463721765513 4.1956113745077e-18 -0.141033031163582 0.721487147805622 mirMAP -0.379663237372169 6.7819367742566e-06 NA NA NA hsa-miR-335-3p TLR5 2.29463721765513 4.1956113745077e-18 -0.542014619328662 0.00287652414298483 MirTarget -0.220421468923865 1.10828691091354e-08 NA NA NA hsa-miR-18a-5p TLR6 2.04701000113742 1.30593450319289e-12 0.11108741675508 0.604183858037807 mirMAP -0.140834328093827 0.00110026979513539 NA NA NA hsa-miR-335-3p TLR6 2.29463721765513 4.1956113745077e-18 0.11108741675508 0.604183858037807 mirMAP -0.145038729069866 0.00165326737887776 NA NA NA hsa-miR-183-5p TMCC3 2.08412478942637 1.08931431254487e-10 -0.610073543057948 0.00290970442243972 MirTarget;miRNATAP -0.127308279901335 0.000663239446716489 NA NA NA hsa-miR-200b-3p TMEFF2 2.06025765178663 3.07718049337497e-10 -2.42593068961104 8.20730991998178e-08 MirTarget;TargetScan -0.666358842419847 2.58075584135151e-17 NA NA NA hsa-miR-335-3p TMEFF2 2.29463721765513 4.1956113745077e-18 -2.42593068961104 8.20730991998178e-08 mirMAP -0.702688553360869 2.59919447435143e-13 NA NA NA hsa-miR-146b-5p TMEM100 2.23105707690238 3.83997814011313e-23 -3.27195385316868 6.21442061957714e-15 miRanda -0.869196199675305 7.90798995747021e-17 NA NA NA hsa-miR-183-5p TMEM108 2.08412478942637 1.08931431254487e-10 -1.3113142499809 1.81979452471885e-09 miRNAWalker2_validate -0.391096569710113 1.06744311780889e-25 NA NA NA hsa-miR-194-5p TMEM108 2.24386881692218 9.35116329002209e-11 -1.3113142499809 1.81979452471885e-09 MirTarget -0.363937621743665 1.20550836049716e-25 NA NA NA hsa-miR-200a-3p TMEM108 2.02394729844446 2.21240501925011e-08 -1.3113142499809 1.81979452471885e-09 mirMAP -0.353311911616685 6.70834265342223e-26 NA NA NA hsa-miR-200a-3p TMEM130 2.02394729844446 2.21240501925011e-08 -0.072012036891545 0.857383140827843 MirTarget -0.548655528970858 3.89465075971366e-19 NA NA NA hsa-miR-141-5p TMEM132B 2.13747696823946 1.73124674554872e-11 -0.830474277127698 0.0108398389130459 MirTarget;mirMAP -0.358322672405625 1.07429896382839e-09 NA NA NA hsa-miR-146b-5p TMEM132B 2.23105707690238 3.83997814011313e-23 -0.830474277127698 0.0108398389130459 mirMAP -0.49560686190903 3.97330567446979e-10 NA NA NA hsa-miR-335-3p TMEM132B 2.29463721765513 4.1956113745077e-18 -0.830474277127698 0.0108398389130459 mirMAP -0.330557353227133 2.15541704416554e-06 NA NA NA hsa-miR-146b-5p TMEM132E 2.23105707690238 3.83997814011313e-23 -0.451961554569855 0.141609945011172 miRanda -0.164955223826532 0.0319212262473063 NA NA NA hsa-miR-146b-5p TMEM136 2.23105707690238 3.83997814011313e-23 -0.269780737415521 0.169447074380575 miRanda;miRNATAP -0.273554499866744 1.00704846033349e-08 NA NA NA hsa-miR-192-5p TMEM136 2.0867723747501 3.57854249239079e-08 -0.269780737415521 0.169447074380575 miRNAWalker2_validate -0.20956477160737 1.30549229147536e-12 NA NA NA hsa-miR-200b-3p TMEM136 2.06025765178663 3.07718049337497e-10 -0.269780737415521 0.169447074380575 TargetScan -0.273342489646391 2.82986643677767e-16 NA NA NA hsa-miR-335-3p TMEM136 2.29463721765513 4.1956113745077e-18 -0.269780737415521 0.169447074380575 MirTarget -0.205995031930636 7.89566320476932e-07 NA NA NA hsa-miR-192-5p TMEM154 2.0867723747501 3.57854249239079e-08 -0.610691566464332 0.0128189693981817 mirMAP -0.134591559439325 0.000462357586585758 NA NA NA hsa-miR-335-3p TMEM154 2.29463721765513 4.1956113745077e-18 -0.610691566464332 0.0128189693981817 mirMAP -0.178228676803773 0.000777087396573293 NA NA NA hsa-miR-335-3p TMEM156 2.29463721765513 4.1956113745077e-18 -0.0509257372877574 0.860855057623451 MirTarget -0.156043212559064 0.0128896968057507 NA NA NA hsa-miR-192-5p TMEM169 2.0867723747501 3.57854249239079e-08 0.160305852802737 0.4754028858431 miRNAWalker2_validate -0.123841264547483 0.00039914015236008 NA NA NA hsa-miR-146b-5p TMEM17 2.23105707690238 3.83997814011313e-23 0.120835414929376 0.517397662876049 miRanda -0.187039400344708 4.80684907687715e-05 NA NA NA hsa-miR-192-5p TMEM17 2.0867723747501 3.57854249239079e-08 0.120835414929376 0.517397662876049 miRNAWalker2_validate -0.131853583471726 4.75087075893918e-06 NA NA NA hsa-miR-200b-3p TMEM17 2.06025765178663 3.07718049337497e-10 0.120835414929376 0.517397662876049 MirTarget;TargetScan -0.120821757628461 0.000289999575811601 NA NA NA hsa-miR-18a-5p TMEM170B 2.04701000113742 1.30593450319289e-12 -0.410928074487889 0.068480801438453 MirTarget;miRNATAP -0.242388864470047 6.15139414313258e-08 NA NA NA hsa-miR-200a-3p TMEM170B 2.02394729844446 2.21240501925011e-08 -0.410928074487889 0.068480801438453 MirTarget;miRNATAP -0.28485327832423 4.47766128905962e-16 NA NA NA hsa-miR-200b-3p TMEM170B 2.06025765178663 3.07718049337497e-10 -0.410928074487889 0.068480801438453 TargetScan -0.307541913896212 1.5465227988557e-15 NA NA NA hsa-miR-21-5p TMEM170B 2.21515015440792 6.0468197386674e-49 -0.410928074487889 0.068480801438453 mirMAP -0.336115264942506 9.18489277029264e-06 NA NA NA hsa-miR-335-3p TMEM170B 2.29463721765513 4.1956113745077e-18 -0.410928074487889 0.068480801438453 mirMAP -0.222100325258723 3.97381408700801e-06 NA NA NA hsa-miR-935 TMEM170B 2.321600496365 1.00042201726114e-07 -0.410928074487889 0.068480801438453 mirMAP -0.187200604185019 3.59502347442859e-09 NA NA NA hsa-miR-146b-5p TMEM185A 2.23105707690238 3.83997814011313e-23 -0.31523635159762 0.00169350174793378 miRanda -0.152122739649428 4.05588519001361e-10 NA NA NA hsa-miR-335-3p TMEM213 2.29463721765513 4.1956113745077e-18 -1.25023496143714 0.0151535674805753 mirMAP -0.275130480892275 0.013924689185685 NA NA NA hsa-miR-335-3p TMEM220 2.29463721765513 4.1956113745077e-18 -1.65487053871941 2.13516085924556e-13 mirMAP -0.360198410051975 1.80716228582599e-13 NA NA NA hsa-miR-335-3p TMEM236 2.29463721765513 4.1956113745077e-18 -1.42419617298612 0.000968222040553198 mirMAP -0.19612426109103 0.0377313738505376 NA NA NA hsa-miR-183-5p TMEM245 2.08412478942637 1.08931431254487e-10 -0.242721302151875 0.0930172579576728 miRNAWalker2_validate -0.233424403194951 7.55068175107412e-22 NA NA NA hsa-miR-200a-3p TMEM245 2.02394729844446 2.21240501925011e-08 -0.242721302151875 0.0930172579576728 mirMAP -0.225336789498134 1.35509887910752e-25 NA NA NA hsa-miR-200b-3p TMEM245 2.06025765178663 3.07718049337497e-10 -0.242721302151875 0.0930172579576728 TargetScan -0.232632184250286 2.9519181237607e-22 NA NA NA hsa-miR-21-5p TMEM245 2.21515015440792 6.0468197386674e-49 -0.242721302151875 0.0930172579576728 miRNAWalker2_validate -0.218389171822637 6.40278187413313e-06 NA NA NA hsa-miR-335-3p TMEM245 2.29463721765513 4.1956113745077e-18 -0.242721302151875 0.0930172579576728 mirMAP -0.185810985789716 8.70491866799706e-10 NA NA NA hsa-miR-200b-3p TMEM25 2.06025765178663 3.07718049337497e-10 -1.69290425548355 2.07356640961023e-11 mirMAP -0.305666710121843 2.27871638837161e-11 NA NA NA hsa-miR-194-5p TMEM43 2.24386881692218 9.35116329002209e-11 0.0145253608400795 0.898804510538956 MirTarget;miRNATAP -0.176092017310755 2.52427076330475e-23 NA NA NA hsa-miR-200b-3p TMEM43 2.06025765178663 3.07718049337497e-10 0.0145253608400795 0.898804510538956 MirTarget -0.19435912478914 1.59939708928372e-25 NA NA NA hsa-miR-335-3p TMEM43 2.29463721765513 4.1956113745077e-18 0.0145253608400795 0.898804510538956 mirMAP -0.100135068799586 3.7883971336548e-05 NA NA NA hsa-miR-146b-5p TMEM47 2.23105707690238 3.83997814011313e-23 -0.85850651693283 0.00027718244841934 miRanda -0.400540490256763 2.51695000068604e-12 NA NA NA hsa-miR-335-3p TMEM47 2.29463721765513 4.1956113745077e-18 -0.85850651693283 0.00027718244841934 MirTarget;mirMAP -0.410069519234229 3.17949108753769e-17 NA NA NA hsa-miR-183-5p TMEM56 2.08412478942637 1.08931431254487e-10 -0.651275261976962 0.00109328650423537 MirTarget -0.144946132699426 6.54386874313528e-05 NA NA NA hsa-miR-200a-3p TMEM56 2.02394729844446 2.21240501925011e-08 -0.651275261976962 0.00109328650423537 MirTarget;miRNATAP -0.10118358594979 0.00209466550634521 NA NA NA hsa-miR-200b-3p TMEM56 2.06025765178663 3.07718049337497e-10 -0.651275261976962 0.00109328650423537 MirTarget -0.120687832485574 0.000813107846360376 NA NA NA hsa-miR-21-5p TMEM56 2.21515015440792 6.0468197386674e-49 -0.651275261976962 0.00109328650423537 miRNAWalker2_validate;mirMAP -0.224438512352995 0.000966225188268164 NA NA NA hsa-miR-335-3p TMEM56 2.29463721765513 4.1956113745077e-18 -0.651275261976962 0.00109328650423537 MirTarget -0.152895112248113 0.00040262257444021 NA NA NA hsa-miR-92a-1-5p TMEM56 2.04820501765632 9.32117486799495e-13 -0.651275261976962 0.00109328650423537 MirTarget -0.14684314145308 0.000401669755912177 NA NA NA hsa-miR-135b-5p TMEM63C 2.80066701698235 2.12546333413447e-11 -2.33652914398606 2.80235725296103e-09 mirMAP -0.299181588682293 3.20620369176601e-07 NA NA NA hsa-miR-1-3p TMEM68 -2.73171785118192 3.4424534921136e-12 0.565902080253638 3.82621518549523e-06 MirTarget -0.129531993235625 2.5253228801993e-13 NA NA NA hsa-miR-335-3p TMEM74 2.29463721765513 4.1956113745077e-18 -1.41185035582608 7.96445740758108e-05 MirTarget -0.428203243600268 2.28769665251392e-08 NA NA NA hsa-miR-146b-5p TMEM80 2.23105707690238 3.83997814011313e-23 -0.465945208292028 2.1105655064703e-05 miRanda -0.131961249658931 1.20008155310196e-06 NA NA NA hsa-miR-146b-5p TMEM88 2.23105707690238 3.83997814011313e-23 -0.695393115127267 0.000744308638485226 miRanda -0.201890282306922 8.65018803641971e-05 NA NA NA hsa-miR-335-3p TMOD1 2.29463721765513 4.1956113745077e-18 -0.983884056799262 1.09276139844945e-07 mirMAP -0.363734335032211 8.42951548393597e-22 NA NA NA hsa-miR-935 TMOD1 2.321600496365 1.00042201726114e-07 -0.983884056799262 1.09276139844945e-07 mirMAP -0.228038388606641 4.9138831210499e-19 NA NA NA hsa-miR-196b-5p TMOD2 4.51951031652328 7.04026169031626e-18 -0.644687820828108 0.00111217170460963 miRNATAP -0.114121184366927 7.29469177860208e-08 NA NA NA hsa-miR-200a-5p TMOD2 2.19152245759943 3.17968183522514e-11 -0.644687820828108 0.00111217170460963 mirMAP -0.319171416046029 1.38986018289943e-22 NA NA NA hsa-miR-335-3p TMOD2 2.29463721765513 4.1956113745077e-18 -0.644687820828108 0.00111217170460963 mirMAP -0.26091683734954 4.25908691737648e-10 NA NA NA hsa-miR-92a-1-5p TMPRSS15 2.04820501765632 9.32117486799495e-13 -3.80162485084749 1.78943354021749e-06 MirTarget -0.503826354948638 0.00276253029163508 NA NA NA hsa-miR-183-5p TMSB4Y 2.08412478942637 1.08931431254487e-10 -1.87651596615488 0.00437003402445257 miRNATAP -0.349726436773003 0.0037362110175177 NA NA NA hsa-miR-335-3p TMTC1 2.29463721765513 4.1956113745077e-18 -1.17602634727033 3.29898954657157e-05 mirMAP -0.520208453103648 3.19489917815996e-19 NA NA NA hsa-miR-18a-5p TMX4 2.04701000113742 1.30593450319289e-12 -0.330403187240345 0.0125813746541551 MirTarget -0.120031563215866 5.90905258079748e-06 NA NA NA hsa-miR-200b-3p TMX4 2.06025765178663 3.07718049337497e-10 -0.330403187240345 0.0125813746541551 TargetScan -0.125218916229639 8.59396680856445e-08 NA NA NA hsa-miR-21-5p TMX4 2.21515015440792 6.0468197386674e-49 -0.330403187240345 0.0125813746541551 miRNAWalker2_validate;mirMAP -0.192227592579899 1.58300156345407e-05 NA NA NA hsa-miR-335-3p TMX4 2.29463721765513 4.1956113745077e-18 -0.330403187240345 0.0125813746541551 MirTarget;mirMAP -0.135485708060509 1.5778062125522e-06 NA NA NA hsa-miR-335-3p TNFAIP8 2.29463721765513 4.1956113745077e-18 -0.544430601438105 0.000795469319100409 mirMAP -0.184971176040582 9.1912193627843e-08 NA NA NA hsa-miR-200a-3p TNFAIP8L1 2.02394729844446 2.21240501925011e-08 -0.0921183470809117 0.506443667576578 mirMAP -0.160620715010028 1.21246223225949e-13 NA NA NA hsa-miR-141-5p TNRC6B 2.13747696823946 1.73124674554872e-11 0.0200605311980917 0.853993906874431 mirMAP -0.106611590904652 5.0505201830493e-08 NA NA NA hsa-miR-183-5p TNRC6B 2.08412478942637 1.08931431254487e-10 0.0200605311980917 0.853993906874431 miRNAWalker2_validate -0.114336247742014 2.63802632721441e-09 NA NA NA hsa-miR-200a-3p TNRC6C 2.02394729844446 2.21240501925011e-08 0.102967367235975 0.501424634724233 mirMAP -0.143474500665317 4.10809792287376e-09 NA NA NA hsa-miR-335-3p TNRC6C 2.29463721765513 4.1956113745077e-18 0.102967367235975 0.501424634724233 mirMAP -0.12312168328919 0.000172224583459303 NA NA NA hsa-miR-135b-5p TNS1 2.80066701698235 2.12546333413447e-11 -1.07943190532407 0.000652796402100098 mirMAP -0.394692933379247 2.16901539960933e-19 NA NA NA hsa-miR-18a-5p TNS1 2.04701000113742 1.30593450319289e-12 -1.07943190532407 0.000652796402100098 mirMAP -0.696908136524708 1.56990997990809e-34 NA NA NA hsa-miR-200a-3p TNS1 2.02394729844446 2.21240501925011e-08 -1.07943190532407 0.000652796402100098 MirTarget -0.62215133798183 6.70782414321627e-45 NA NA NA hsa-miR-135b-5p TOM1L2 2.80066701698235 2.12546333413447e-11 -0.994181490940386 3.17616240628865e-12 mirMAP -0.121599902811236 1.15457706464145e-08 NA NA NA hsa-miR-200a-3p TOM1L2 2.02394729844446 2.21240501925011e-08 -0.994181490940386 3.17616240628865e-12 miRNATAP -0.183777086423467 2.01542076581761e-15 NA NA NA hsa-miR-192-5p TOR1AIP1 2.0867723747501 3.57854249239079e-08 -0.562316478900568 1.82898321931949e-07 miRNAWalker2_validate -0.18618085379582 7.04519235540636e-35 NA NA NA hsa-miR-200b-3p TOR1AIP1 2.06025765178663 3.07718049337497e-10 -0.562316478900568 1.82898321931949e-07 TargetScan -0.202239007384029 2.49477975505636e-30 NA NA NA hsa-miR-146b-5p TOX 2.23105707690238 3.83997814011313e-23 -1.5520618363727 1.65462553105166e-07 PITA;miRanda -0.396398121776723 9.24840809214308e-08 NA NA NA hsa-miR-935 TOX 2.321600496365 1.00042201726114e-07 -1.5520618363727 1.65462553105166e-07 MirTarget;PITA;miRNATAP -0.316427835513847 3.70544826451705e-14 NA NA NA hsa-miR-146b-5p TP53INP2 2.23105707690238 3.83997814011313e-23 -1.17801684099823 1.14814876900995e-10 miRanda -0.424235655520542 2.07493739912766e-22 NA NA NA hsa-miR-192-5p TP53INP2 2.0867723747501 3.57854249239079e-08 -1.17801684099823 1.14814876900995e-10 mirMAP -0.179387121645363 4.94409064276492e-10 NA NA NA hsa-miR-200a-3p TP63 2.02394729844446 2.21240501925011e-08 -0.362887529253623 0.381905737656846 MirTarget -0.233934206905721 0.000553071561378296 NA NA NA hsa-miR-146b-5p TPM1 2.23105707690238 3.83997814011313e-23 -1.25535971958143 8.44875947902356e-08 miRanda -0.533040184541613 5.89662011548342e-22 NA NA NA hsa-miR-183-5p TPM1 2.08412478942637 1.08931431254487e-10 -1.25535971958143 8.44875947902356e-08 MirTarget;miRNATAP -0.502287386075581 6.65173181483799e-41 NA NA NA hsa-miR-21-5p TPM1 2.21515015440792 6.0468197386674e-49 -1.25535971958143 8.44875947902356e-08 miRNAWalker2_validate;miRTarBase -0.685577834600619 2.31498153951898e-19 20952761;23558936 These two miRNAs have previously been identified as being overexpressed in MCF-7 breast cancer cells with miR-21 specifically implicated in down-regulating the tumor suppressor gene tropomyosin-1;Furthermore miR-21 mimic or inhibitor significantly reduced or increased the expression of PDCD4 and TPM1; MiR-21 is overexpressed in RCC tissue and modulates the growth apoptosis and cell cycle progression of RCC cells and regulates the expression of PDCD4 and TPM1 ;progression breast cancer;kidney renal cell cancer hsa-miR-335-3p TPO 2.29463721765513 4.1956113745077e-18 -1.86991300300667 2.19534309631542e-05 mirMAP -0.728665581044725 2.12173595186446e-15 NA NA NA hsa-miR-92a-1-5p TPPP 2.04820501765632 9.32117486799495e-13 -0.580083958126981 0.0295750850510786 mirMAP -0.160938366428315 0.00368073490551481 NA NA NA hsa-miR-21-5p TPRG1L 2.21515015440792 6.0468197386674e-49 -0.616973838753045 5.38924149646892e-12 miRNAWalker2_validate;MirTarget -0.226881348775698 4.34333978320703e-14 NA NA NA hsa-miR-146b-5p TRAK2 2.23105707690238 3.83997814011313e-23 -0.120950192085154 0.211315124945868 miRanda -0.110210003014731 3.0986353490435e-06 NA NA NA hsa-miR-200b-3p TRAM1L1 2.06025765178663 3.07718049337497e-10 -0.872008783035565 0.00132824574110401 MirTarget -0.376365293049009 8.00343308487571e-16 NA NA NA hsa-miR-146b-5p TRHDE 2.23105707690238 3.83997814011313e-23 -1.18952923575798 0.0121330727820621 MirTarget;miRanda -0.357119381771618 0.00260185059910629 NA NA NA hsa-miR-200b-3p TRIL 2.06025765178663 3.07718049337497e-10 -0.258907477913871 0.199355796714117 MirTarget -0.16108977260278 6.9882002811152e-06 NA NA NA hsa-miR-192-5p TRIM23 2.0867723747501 3.57854249239079e-08 -0.342721432687234 0.00211580921154758 miRNAWalker2_validate -0.172431252443368 1.21328425432394e-27 NA NA NA hsa-miR-194-5p TRIM23 2.24386881692218 9.35116329002209e-11 -0.342721432687234 0.00211580921154758 MirTarget -0.166273324468676 3.11595258420659e-21 26221053 Transcripts encoding tripartite motif containing 23 TRIM23 a ubiquitin ligase involved in NF-κB activation and chromosome 21 open reading frame 91 C21ORF91 a protein of unknown function were identified as direct targets of miR-194 in HCC cells; knocking down either protein decreased the activity of a luciferase NF-κB reporter liver cancer hsa-miR-200a-3p TRIM23 2.02394729844446 2.21240501925011e-08 -0.342721432687234 0.00211580921154758 MirTarget -0.160355574361991 4.01695645837778e-21 NA NA NA hsa-miR-200b-3p TRIM23 2.06025765178663 3.07718049337497e-10 -0.342721432687234 0.00211580921154758 MirTarget -0.172831000805923 2.72403226114898e-20 NA NA NA hsa-miR-146b-5p TRIM9 2.23105707690238 3.83997814011313e-23 -0.689364037709427 0.0131135132409897 PITA;miRanda -0.297379864082677 1.55035315244754e-05 NA NA NA hsa-miR-200b-3p TRIO 2.06025765178663 3.07718049337497e-10 0.709506263927999 2.17818099879629e-06 TargetScan -0.13718873323502 3.61354594636322e-07 NA NA NA hsa-miR-183-5p TRO 2.08412478942637 1.08931431254487e-10 -0.148177017444581 0.473781590601723 miRNAWalker2_validate -0.307530651759931 2.89315441153815e-18 NA NA NA hsa-miR-192-5p TRPC1 2.0867723747501 3.57854249239079e-08 -0.704677053980514 0.00534368864806038 miRNAWalker2_validate -0.389586869598043 3.50668563206409e-27 NA NA NA hsa-miR-335-3p TRPC1 2.29463721765513 4.1956113745077e-18 -0.704677053980514 0.00534368864806038 mirMAP -0.373618422232911 1.49763354151188e-12 NA NA NA hsa-miR-335-3p TRPC4 2.29463721765513 4.1956113745077e-18 -0.714073677598865 0.0189299452148202 mirMAP -0.446327299695839 1.97974712044327e-12 NA NA NA hsa-miR-183-5p TRPC6 2.08412478942637 1.08931431254487e-10 0.183575673494753 0.282867325468071 MirTarget -0.119144694189018 0.00011235246724863 NA NA NA hsa-miR-335-3p TRPC6 2.29463721765513 4.1956113745077e-18 0.183575673494753 0.282867325468071 MirTarget;mirMAP -0.104818264023394 0.00443081790340103 NA NA NA hsa-miR-141-5p TRPS1 2.13747696823946 1.73124674554872e-11 -0.190955899174114 0.441089792195844 miRNATAP -0.389190856071164 6.08079034347915e-20 NA NA NA hsa-miR-194-5p TRPS1 2.24386881692218 9.35116329002209e-11 -0.190955899174114 0.441089792195844 MirTarget;miRNATAP -0.40969832553347 4.38513337351725e-27 NA NA NA hsa-miR-200a-5p TRPS1 2.19152245759943 3.17968183522514e-11 -0.190955899174114 0.441089792195844 miRNATAP -0.366398281376637 5.51382212877224e-19 NA NA NA hsa-miR-335-3p TRPS1 2.29463721765513 4.1956113745077e-18 -0.190955899174114 0.441089792195844 mirMAP -0.279254402895393 1.0092652826366e-07 NA NA NA hsa-miR-92a-1-5p TRPS1 2.04820501765632 9.32117486799495e-13 -0.190955899174114 0.441089792195844 MirTarget -0.31427794302351 2.82974917703855e-10 NA NA NA hsa-miR-146b-5p TSC22D1 2.23105707690238 3.83997814011313e-23 -0.528505038934999 1.98487242401898e-05 miRanda -0.246162978168279 6.89219982329905e-17 NA NA NA hsa-miR-200b-3p TSC22D1 2.06025765178663 3.07718049337497e-10 -0.528505038934999 1.98487242401898e-05 MirTarget;TargetScan -0.149233700643198 6.67395833868741e-12 NA NA NA hsa-miR-146b-3p TSC22D2 2.08650140817622 5.3293570720033e-22 -0.442389045444121 7.38597549150903e-05 MirTarget;PITA -0.101111875824278 0.0005394103820092 NA NA NA hsa-miR-146b-5p TSC22D2 2.23105707690238 3.83997814011313e-23 -0.442389045444121 7.38597549150903e-05 miRanda -0.147983122432108 7.32823588677309e-08 NA NA NA hsa-miR-200b-3p TSC22D2 2.06025765178663 3.07718049337497e-10 -0.442389045444121 7.38597549150903e-05 MirTarget;TargetScan -0.100591969139521 4.41857168619621e-07 NA NA NA hsa-miR-18a-5p TSC22D3 2.04701000113742 1.30593450319289e-12 -1.74603210320545 3.61843236827956e-15 miRNAWalker2_validate -0.418370912316003 1.81472950101773e-21 NA NA NA hsa-miR-335-3p TSHR 2.29463721765513 4.1956113745077e-18 -0.51336985509336 0.0928472253682084 mirMAP -0.197759731879651 0.00272442998813369 NA NA NA hsa-miR-146b-5p TSHZ1 2.23105707690238 3.83997814011313e-23 -0.609478839945522 3.02181600225133e-05 miRanda -0.273339790626032 6.59404462102611e-15 NA NA NA hsa-miR-194-5p TSHZ1 2.24386881692218 9.35116329002209e-11 -0.609478839945522 3.02181600225133e-05 miRNATAP -0.172520133316038 7.83050155440205e-13 NA NA NA hsa-miR-21-5p TSHZ1 2.21515015440792 6.0468197386674e-49 -0.609478839945522 3.02181600225133e-05 miRNATAP -0.370915282220261 8.61984300552885e-15 NA NA NA hsa-miR-335-3p TSHZ1 2.29463721765513 4.1956113745077e-18 -0.609478839945522 3.02181600225133e-05 mirMAP -0.192575420878093 5.4973074509668e-10 NA NA NA hsa-miR-200a-5p TSHZ2 2.19152245759943 3.17968183522514e-11 0.244447329749579 0.299253485290493 mirMAP -0.288599373980184 6.24282854007726e-13 NA NA NA hsa-miR-335-3p TSHZ2 2.29463721765513 4.1956113745077e-18 0.244447329749579 0.299253485290493 mirMAP -0.184844666751894 0.000255064743774119 NA NA NA hsa-miR-18a-5p TSHZ3 2.04701000113742 1.30593450319289e-12 -0.556373800983045 0.0151607966428605 MirTarget;miRNATAP -0.42942110193356 8.3356750420993e-24 NA NA NA hsa-miR-200a-3p TSHZ3 2.02394729844446 2.21240501925011e-08 -0.556373800983045 0.0151607966428605 MirTarget;miRNATAP -0.407004010404615 9.50365420909098e-35 NA NA NA hsa-miR-21-5p TSHZ3 2.21515015440792 6.0468197386674e-49 -0.556373800983045 0.0151607966428605 miRNAWalker2_validate -0.406515247243031 1.09107311064047e-07 NA NA NA hsa-miR-335-3p TSHZ3 2.29463721765513 4.1956113745077e-18 -0.556373800983045 0.0151607966428605 MirTarget -0.357139690530331 5.14809630933375e-14 NA NA NA hsa-miR-935 TSHZ3 2.321600496365 1.00042201726114e-07 -0.556373800983045 0.0151607966428605 PITA;miRNATAP -0.193795421118545 1.88520714484738e-09 NA NA NA hsa-miR-183-5p TSPAN11 2.08412478942637 1.08931431254487e-10 -0.633628780746822 0.00869545910541402 mirMAP -0.336384423579045 9.84952995341829e-16 NA NA NA hsa-miR-335-3p TSPAN11 2.29463721765513 4.1956113745077e-18 -0.633628780746822 0.00869545910541402 mirMAP -0.274347524285829 9.33994846739129e-08 NA NA NA hsa-miR-146b-5p TSPAN12 2.23105707690238 3.83997814011313e-23 -0.571917595110277 0.00359116641858879 miRanda -0.118178241907866 0.0165149520842476 NA NA NA hsa-miR-146b-5p TSPAN18 2.23105707690238 3.83997814011313e-23 -0.372928658111706 0.117111458292415 miRanda -0.354499744363252 7.88091795966216e-10 NA NA NA hsa-miR-196a-5p TSPAN18 5.05945965885472 4.48343841468539e-25 -0.372928658111706 0.117111458292415 miRNATAP -0.133617129315041 7.21021808630764e-07 NA NA NA hsa-miR-196b-5p TSPAN18 4.51951031652328 7.04026169031626e-18 -0.372928658111706 0.117111458292415 miRNATAP -0.148077192022337 4.20571592431824e-09 NA NA NA hsa-miR-146b-5p TSPAN2 2.23105707690238 3.83997814011313e-23 -1.23254115286361 3.37050594572715e-05 miRanda -0.486796563852678 1.97720502698827e-11 NA NA NA hsa-miR-146b-5p TSPYL1 2.23105707690238 3.83997814011313e-23 -0.577255370418471 9.4468155155006e-11 miRanda -0.134997961376691 1.35114893412077e-09 NA NA NA hsa-miR-335-3p TSPYL4 2.29463721765513 4.1956113745077e-18 -0.395086202543128 0.00171193531359432 mirMAP -0.139873196962621 1.84812192259125e-07 NA NA NA hsa-miR-135b-5p TSTD2 2.80066701698235 2.12546333413447e-11 -0.274268349764307 0.0113892625470047 MirTarget -0.114687578751309 4.13990991295029e-14 NA NA NA hsa-miR-192-5p TSTD2 2.0867723747501 3.57854249239079e-08 -0.274268349764307 0.0113892625470047 MirTarget -0.162095385857542 9.47624083767484e-26 NA NA NA hsa-miR-141-5p TTBK2 2.13747696823946 1.73124674554872e-11 -0.205637655809689 0.212190206603531 MirTarget -0.252259526544912 6.77021857874954e-19 NA NA NA hsa-miR-146b-5p TTBK2 2.23105707690238 3.83997814011313e-23 -0.205637655809689 0.212190206603531 mirMAP -0.171049243108754 2.52764647510746e-05 NA NA NA hsa-miR-200a-3p TTBK2 2.02394729844446 2.21240501925011e-08 -0.205637655809689 0.212190206603531 MirTarget -0.224960448511061 4.90966235631824e-19 NA NA NA hsa-miR-335-3p TTBK2 2.29463721765513 4.1956113745077e-18 -0.205637655809689 0.212190206603531 MirTarget;mirMAP -0.170650682666599 1.08584175216057e-06 NA NA NA hsa-miR-935 TTBK2 2.321600496365 1.00042201726114e-07 -0.205637655809689 0.212190206603531 mirMAP -0.106510069948978 5.42273701965333e-06 NA NA NA hsa-miR-183-5p TTC14 2.08412478942637 1.08931431254487e-10 -0.165834824080406 0.370234160666997 miRNATAP -0.183308173134846 2.51839483834142e-08 NA NA NA hsa-miR-335-3p TTC14 2.29463721765513 4.1956113745077e-18 -0.165834824080406 0.370234160666997 mirMAP -0.174863213584438 9.29985347353868e-06 NA NA NA hsa-miR-18a-5p TTC28 2.04701000113742 1.30593450319289e-12 -0.809143870236313 0.000127730189903418 mirMAP -0.372124570321364 2.2655873670314e-20 NA NA NA hsa-miR-335-3p TTC28 2.29463721765513 4.1956113745077e-18 -0.809143870236313 0.000127730189903418 mirMAP -0.317242171238194 8.10189003895792e-13 NA NA NA hsa-miR-141-5p TTC33 2.13747696823946 1.73124674554872e-11 -0.107985966511241 0.337414641328238 MirTarget -0.110654611333384 4.45271820617809e-08 NA NA NA hsa-miR-200a-3p TTLL7 2.02394729844446 2.21240501925011e-08 -1.25626337331144 0.000337426793444403 MirTarget -0.446417308776148 4.88568635043742e-16 NA NA NA hsa-miR-200a-5p TTLL7 2.19152245759943 3.17968183522514e-11 -1.25626337331144 0.000337426793444403 mirMAP -0.498854662783662 4.35343687656055e-17 NA NA NA hsa-miR-335-3p TTLL7 2.29463721765513 4.1956113745077e-18 -1.25626337331144 0.000337426793444403 mirMAP -0.524935412512421 9.08112018835739e-13 NA NA NA hsa-miR-146b-5p TTPA 2.23105707690238 3.83997814011313e-23 -0.38420481446424 0.474766949450436 miRanda -0.271977293979798 0.0429045895329203 NA NA NA hsa-miR-146b-5p TTTY15 2.23105707690238 3.83997814011313e-23 -1.20060221662492 0.137756665920098 miRanda -0.487038115671834 0.0159977158961621 NA NA NA hsa-miR-200a-3p TTYH2 2.02394729844446 2.21240501925011e-08 -0.116076419008623 0.581439261788124 miRNATAP -0.245725745549186 8.64574670575491e-14 NA NA NA hsa-miR-135b-5p TUB 2.80066701698235 2.12546333413447e-11 -1.37670411951109 1.78362089911847e-05 mirMAP -0.36468306237291 9.19793361667067e-16 NA NA NA hsa-miR-141-5p TUB 2.13747696823946 1.73124674554872e-11 -1.37670411951109 1.78362089911847e-05 mirMAP -0.585302077914395 6.5500059750281e-27 NA NA NA hsa-miR-183-5p TUB 2.08412478942637 1.08931431254487e-10 -1.37670411951109 1.78362089911847e-05 MirTarget -0.586096645139792 7.6574939887278e-28 NA NA NA hsa-miR-200b-3p TUBB3 2.06025765178663 3.07718049337497e-10 1.70550558746553 8.12639200368567e-12 TargetScan -0.114227404230901 0.014840997415908 NA NA NA hsa-miR-194-5p TUSC3 2.24386881692218 9.35116329002209e-11 -0.773363556517873 0.000523205378931522 MirTarget -0.317351782848175 6.46851845059319e-19 NA NA NA hsa-miR-335-3p TUSC3 2.29463721765513 4.1956113745077e-18 -0.773363556517873 0.000523205378931522 MirTarget;mirMAP -0.264103602111955 2.80381780750606e-08 NA NA NA hsa-miR-1-3p TWF1 -2.73171785118192 3.4424534921136e-12 0.26265707510963 0.0207377493883191 MirTarget -0.10286529985875 3.27865396756543e-10 NA NA NA hsa-miR-146b-5p TXLNB 2.23105707690238 3.83997814011313e-23 -1.65821602341064 4.85207492282639e-09 miRanda -0.34155949011861 1.94269693635034e-06 NA NA NA hsa-miR-200a-5p TXLNB 2.19152245759943 3.17968183522514e-11 -1.65821602341064 4.85207492282639e-09 MirTarget -0.502376579162269 1.43797994173261e-26 NA NA NA hsa-miR-18a-5p TXNDC15 2.04701000113742 1.30593450319289e-12 -0.541269491654419 1.44216720811775e-08 miRNAWalker2_validate -0.172656356414452 4.44580029427513e-21 NA NA NA hsa-miR-335-3p TXNDC15 2.29463721765513 4.1956113745077e-18 -0.541269491654419 1.44216720811775e-08 mirMAP -0.154438280956467 1.53345907521588e-14 NA NA NA hsa-miR-183-5p TXNIP 2.08412478942637 1.08931431254487e-10 -1.27660062513074 4.10601839671154e-10 miRNAWalker2_validate -0.424922995530094 8.07678262414498e-37 NA NA NA hsa-miR-200a-3p TXNIP 2.02394729844446 2.21240501925011e-08 -1.27660062513074 4.10601839671154e-10 MirTarget -0.303658363630098 3.38490303756931e-21 NA NA NA hsa-miR-146b-5p TXNRD3 2.23105707690238 3.83997814011313e-23 -0.355078938208501 0.110637579726936 miRanda -0.195015922074866 0.000413296477383123 NA NA NA hsa-miR-335-3p TYRP1 2.29463721765513 4.1956113745077e-18 0.493161056912956 0.260932234532277 mirMAP -0.382830511219131 4.62357350192392e-05 NA NA NA hsa-miR-146b-5p UBAP1 2.23105707690238 3.83997814011313e-23 -0.580116317864144 1.04502544534586e-10 miRanda -0.13768994760451 8.08902310230559e-10 NA NA NA hsa-miR-18a-5p UBC 2.04701000113742 1.30593450319289e-12 -0.547103795643103 5.02187280305657e-11 miRNAWalker2_validate -0.108026549544118 1.35317425865265e-10 NA NA NA hsa-miR-146b-5p UBE2E2 2.23105707690238 3.83997814011313e-23 -0.467583385329765 0.0154842772729055 miRanda -0.180307983694398 0.000171013803315152 NA NA NA hsa-miR-335-3p UBE2E2 2.29463721765513 4.1956113745077e-18 -0.467583385329765 0.0154842772729055 mirMAP -0.276871463399624 6.60452751113421e-12 NA NA NA hsa-miR-141-5p UBE2H 2.13747696823946 1.73124674554872e-11 0.0273387763409909 0.772766398379207 miRNATAP -0.111132382562089 3.09977192633767e-11 NA NA NA hsa-miR-146b-5p UBE2Q2 2.23105707690238 3.83997814011313e-23 -0.239899037894862 0.118616481235142 miRanda -0.170846483109517 6.15898194730373e-06 NA NA NA hsa-miR-146b-5p UBE4B 2.23105707690238 3.83997814011313e-23 -0.234890160403762 0.00699649400950057 miRanda -0.137219255424664 5.48623150739907e-11 NA NA NA hsa-miR-335-3p UBL3 2.29463721765513 4.1956113745077e-18 -0.925691828169475 5.01551726319136e-15 MirTarget -0.161416434987308 6.60578168564395e-10 NA NA NA hsa-miR-21-5p UBXN10 2.21515015440792 6.0468197386674e-49 -0.722631468061429 0.0447174779262154 mirMAP -0.497555521866846 4.19513887205081e-05 NA NA NA hsa-miR-335-3p UBXN10 2.29463721765513 4.1956113745077e-18 -0.722631468061429 0.0447174779262154 mirMAP -0.287380895678687 0.000209320277043435 NA NA NA hsa-miR-935 UBXN10 2.321600496365 1.00042201726114e-07 -0.722631468061429 0.0447174779262154 mirMAP -0.258863573785193 4.15276461629155e-07 NA NA NA hsa-miR-1-3p UHMK1 -2.73171785118192 3.4424534921136e-12 0.650903505564446 1.41531118937306e-09 MirTarget -0.140770618980949 3.64305452245023e-20 NA NA NA hsa-miR-200a-3p ULK2 2.02394729844446 2.21240501925011e-08 -0.507777916304274 0.00720267539139616 MirTarget -0.221270827246668 1.02628366232361e-13 NA NA NA hsa-miR-200b-3p ULK2 2.06025765178663 3.07718049337497e-10 -0.507777916304274 0.00720267539139616 MirTarget;TargetScan -0.231597745104915 1.7212853574088e-12 NA NA NA hsa-miR-935 ULK2 2.321600496365 1.00042201726114e-07 -0.507777916304274 0.00720267539139616 MirTarget;PITA;miRNATAP -0.183240870545524 3.34585580413469e-12 NA NA NA hsa-miR-335-3p UNC5C 2.29463721765513 4.1956113745077e-18 -0.178238602102299 0.402140238010829 mirMAP -0.158716543348402 0.000513015006321925 NA NA NA hsa-miR-146b-5p UNC5D 2.23105707690238 3.83997814011313e-23 -3.64613009315552 4.94835759480009e-14 miRanda -0.80950313295072 4.35511294204238e-11 NA NA NA hsa-miR-146b-5p UNC80 2.23105707690238 3.83997814011313e-23 -1.93440601889881 3.16732101418133e-06 miRanda -0.628438099834619 8.84702858251462e-10 NA NA NA hsa-miR-194-5p UNC80 2.24386881692218 9.35116329002209e-11 -1.93440601889881 3.16732101418133e-06 miRNATAP -0.320420627693165 6.22612554382539e-06 NA NA NA hsa-miR-21-5p UNC80 2.21515015440792 6.0468197386674e-49 -1.93440601889881 3.16732101418133e-06 MirTarget -0.898229290707814 1.08081462496132e-10 NA NA NA hsa-miR-335-3p UNC80 2.29463721765513 4.1956113745077e-18 -1.93440601889881 3.16732101418133e-06 mirMAP -0.412414316756759 4.92589125484072e-06 NA NA NA hsa-miR-146b-5p UPK1B 2.23105707690238 3.83997814011313e-23 -3.26901712690444 1.56110875812643e-06 miRanda -0.600983254527182 0.000490866451175288 NA NA NA hsa-miR-146b-5p USP2 2.23105707690238 3.83997814011313e-23 -2.19721865185727 1.17166813672625e-12 miRanda -0.674800399805289 3.48456604516565e-19 NA NA NA hsa-miR-200b-3p USP27X 2.06025765178663 3.07718049337497e-10 0.105236875735044 0.40514235370682 TargetScan -0.109132570916822 9.90531261349787e-07 NA NA NA hsa-miR-146b-5p USP54 2.23105707690238 3.83997814011313e-23 -0.258553178812738 0.0824655774549598 miRanda -0.115037258579337 0.00187075373636182 NA NA NA hsa-miR-335-3p USP9Y 2.29463721765513 4.1956113745077e-18 -1.40132769268578 0.137471061086103 mirMAP -0.644095614403807 0.00155944220546501 NA NA NA hsa-miR-146b-3p UST 2.08650140817622 5.3293570720033e-22 -1.41394764597586 8.19742145654322e-06 MirTarget -0.405324308390038 9.79185363819041e-07 NA NA NA hsa-miR-21-5p UTRN 2.21515015440792 6.0468197386674e-49 -0.341307034762131 0.0355686209546459 miRNAWalker2_validate -0.182640141724198 0.000895317871009116 NA NA NA hsa-miR-335-3p UTS2 2.29463721765513 4.1956113745077e-18 -0.876645323080071 1.48995760379168e-05 MirTarget -0.24081341520152 2.98105649342948e-08 NA NA NA hsa-miR-935 UTY 2.321600496365 1.00042201726114e-07 -1.23736260961566 0.183051234322176 PITA -0.361786519827 0.00697835823068074 NA NA NA hsa-miR-141-5p VAMP1 2.13747696823946 1.73124674554872e-11 -0.344059161980868 0.020540274676963 mirMAP -0.185043556324311 2.33208479318056e-12 NA NA NA hsa-miR-18a-5p VAMP1 2.04701000113742 1.30593450319289e-12 -0.344059161980868 0.020540274676963 mirMAP -0.12122352756826 4.8587067152332e-05 NA NA NA hsa-miR-335-3p VAMP4 2.29463721765513 4.1956113745077e-18 -0.32384713536298 0.000800778887281062 MirTarget;mirMAP -0.128455731801629 2.42331686085991e-10 NA NA NA hsa-miR-146b-3p VANGL2 2.08650140817622 5.3293570720033e-22 -0.695733730024096 0.0380935309762492 PITA -0.373637058834013 1.66694812810155e-05 NA NA NA hsa-miR-146b-5p VAT1 2.23105707690238 3.83997814011313e-23 -0.13395822096223 0.355205390940839 MirTarget;PITA;miRanda;miRNATAP -0.10976555171869 0.00224914233447551 NA NA NA hsa-miR-18a-5p VAT1L 2.04701000113742 1.30593450319289e-12 -1.2975564288276 7.71112308641131e-06 MirTarget -0.321691059559819 3.7476349939507e-08 NA NA NA hsa-miR-200b-3p VAT1L 2.06025765178663 3.07718049337497e-10 -1.2975564288276 7.71112308641131e-06 MirTarget;TargetScan -0.276508933330425 1.11047093921134e-07 NA NA NA hsa-miR-335-3p VAT1L 2.29463721765513 4.1956113745077e-18 -1.2975564288276 7.71112308641131e-06 mirMAP -0.357869023257672 8.96573268048665e-09 NA NA NA hsa-miR-200a-3p VCAM1 2.02394729844446 2.21240501925011e-08 0.619629702942566 0.00353301931056086 miRNAWalker2_validate -0.117289609012904 0.000778152184684981 NA NA NA hsa-miR-1-3p VEGFA -2.73171785118192 3.4424534921136e-12 0.628775505110226 0.000620913144913639 MirTarget -0.160096444278202 2.39807937646162e-09 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-133a-3p VEGFA -2.63342156915404 5.72661351480585e-12 0.628775505110226 0.000620913144913639 miRNAWalker2_validate -0.17467432535846 2.12949891237168e-10 NA NA NA hsa-miR-146b-5p VEZF1 2.23105707690238 3.83997814011313e-23 -0.128939695446817 0.142752999653342 miRanda -0.145727528938481 3.36602141991477e-12 NA NA NA hsa-miR-21-5p VEZF1 2.21515015440792 6.0468197386674e-49 -0.128939695446817 0.142752999653342 mirMAP -0.11702563168664 6.86881329897909e-05 NA NA NA hsa-miR-135b-5p VGLL3 2.80066701698235 2.12546333413447e-11 0.314863164469675 0.263033597488497 mirMAP -0.224719861517771 2.59791270190785e-08 NA NA NA hsa-miR-192-5p VGLL3 2.0867723747501 3.57854249239079e-08 0.314863164469675 0.263033597488497 miRNAWalker2_validate -0.290539198846591 7.9478822269219e-12 NA NA NA hsa-miR-200b-3p VGLL3 2.06025765178663 3.07718049337497e-10 0.314863164469675 0.263033597488497 mirMAP -0.416010929449094 1.86267790688171e-18 NA NA NA hsa-miR-335-3p VGLL3 2.29463721765513 4.1956113745077e-18 0.314863164469675 0.263033597488497 MirTarget;mirMAP -0.186173951312268 0.00213908111101328 NA NA NA hsa-miR-146b-5p VIP 2.23105707690238 3.83997814011313e-23 -2.86051996547017 5.11433949050996e-06 miRanda -1.06276991168707 4.19238067451831e-12 NA NA NA hsa-miR-135b-5p VLDLR 2.80066701698235 2.12546333413447e-11 -1.51502351723723 4.10702622044204e-07 MirTarget -0.306920063771452 1.12068024413019e-12 NA NA NA hsa-miR-200b-3p VLDLR 2.06025765178663 3.07718049337497e-10 -1.51502351723723 4.10702622044204e-07 TargetScan -0.43727672776589 3.73272026772736e-17 NA NA NA hsa-miR-18a-5p VPS13D 2.04701000113742 1.30593450319289e-12 -0.379765434527457 0.000657049427891329 MirTarget -0.155911130931854 7.63431385409316e-13 NA NA NA hsa-miR-335-3p VSTM4 2.29463721765513 4.1956113745077e-18 -0.493998312210794 0.0404612048482649 mirMAP -0.34161460367121 1.1524596593979e-11 NA NA NA hsa-miR-335-3p VWA5A 2.29463721765513 4.1956113745077e-18 -0.885562719218981 2.77130981718945e-06 MirTarget;mirMAP -0.185313034557854 6.37293042140416e-06 NA NA NA hsa-miR-200b-3p WASF1 2.06025765178663 3.07718049337497e-10 -0.152219015266867 0.560115892861614 TargetScan -0.435700616723815 4.20078123559881e-24 NA NA NA hsa-miR-146b-5p WASF2 2.23105707690238 3.83997814011313e-23 -0.399553135592088 1.50019658503691e-05 miRNATAP -0.111479232187174 1.06907704258073e-06 NA NA NA hsa-miR-18a-5p WASF2 2.04701000113742 1.30593450319289e-12 -0.399553135592088 1.50019658503691e-05 mirMAP -0.110057153493066 1.99077207806247e-09 NA NA NA hsa-miR-146b-5p WASF3 2.23105707690238 3.83997814011313e-23 -1.11115772222304 0.000353153562928233 miRanda;miRNATAP -0.477525955686244 3.34596166720091e-10 NA NA NA hsa-miR-200a-3p WASF3 2.02394729844446 2.21240501925011e-08 -1.11115772222304 0.000353153562928233 miRNAWalker2_validate;miRTarBase -0.376128282411932 1.937796562519e-14 NA NA NA hsa-miR-200b-3p WASF3 2.06025765178663 3.07718049337497e-10 -1.11115772222304 0.000353153562928233 miRNAWalker2_validate;miRTarBase;TargetScan -0.412650541045337 2.0149023151053e-14 NA NA NA hsa-miR-200a-3p WBP1L 2.02394729844446 2.21240501925011e-08 -0.377971404363762 8.29956294454323e-05 mirMAP -0.133780982849692 1.51589053609323e-19 NA NA NA hsa-miR-200b-3p WBP1L 2.06025765178663 3.07718049337497e-10 -0.377971404363762 8.29956294454323e-05 MirTarget;TargetScan -0.147429960768648 1.03657509289249e-19 NA NA NA hsa-miR-146b-5p WBSCR17 2.23105707690238 3.83997814011313e-23 -0.908040661433055 0.00293558991270599 miRanda -0.39158842053153 1.91909299809586e-07 NA NA NA hsa-miR-146b-3p WDFY3 2.08650140817622 5.3293570720033e-22 -0.20090024293122 0.0966993995672952 MirTarget -0.11871789931806 0.000143800734505626 NA NA NA hsa-miR-146b-5p WDFY3 2.23105707690238 3.83997814011313e-23 -0.20090024293122 0.0966993995672952 miRanda -0.128763404417943 1.48767316467675e-05 NA NA NA hsa-miR-200a-3p WDFY3 2.02394729844446 2.21240501925011e-08 -0.20090024293122 0.0966993995672952 MirTarget;miRNATAP -0.116208113229202 1.54337244565969e-09 NA NA NA hsa-miR-200a-5p WDFY3 2.19152245759943 3.17968183522514e-11 -0.20090024293122 0.0966993995672952 mirMAP -0.116649464970191 2.61507181164972e-08 NA NA NA hsa-miR-200b-3p WDFY3 2.06025765178663 3.07718049337497e-10 -0.20090024293122 0.0966993995672952 MirTarget;TargetScan -0.121485683961825 9.89561489958834e-09 NA NA NA hsa-miR-183-5p WDFY4 2.08412478942637 1.08931431254487e-10 0.230707088408966 0.420325902236852 mirMAP -0.153032290111843 0.00326799093827466 NA NA NA hsa-miR-335-3p WDFY4 2.29463721765513 4.1956113745077e-18 0.230707088408966 0.420325902236852 mirMAP -0.179956640330087 0.00355517248279273 NA NA NA hsa-miR-335-3p WDPCP 2.29463721765513 4.1956113745077e-18 -0.158782544438583 0.114215541640989 mirMAP -0.103252955614661 1.21447320032046e-06 NA NA NA hsa-miR-146b-5p WDR31 2.23105707690238 3.83997814011313e-23 -0.0992060295406603 0.534893701623993 miRanda -0.154011405175584 9.37003967201096e-05 NA NA NA hsa-miR-335-3p WDR35 2.29463721765513 4.1956113745077e-18 0.0811467732124389 0.666521054365166 MirTarget -0.101192666985707 0.0127489713381591 NA NA NA hsa-miR-141-5p WDR47 2.13747696823946 1.73124674554872e-11 -0.378252468795409 0.000312581763040392 MirTarget -0.146318113570073 2.46232103095804e-15 NA NA NA hsa-miR-146b-5p WDR47 2.23105707690238 3.83997814011313e-23 -0.378252468795409 0.000312581763040392 PITA;miRanda -0.146633106859059 1.11857182012515e-08 NA NA NA hsa-miR-192-5p WDR47 2.0867723747501 3.57854249239079e-08 -0.378252468795409 0.000312581763040392 miRNAWalker2_validate -0.164915602787692 1.48765020170802e-28 NA NA NA hsa-miR-21-5p WDR7 2.21515015440792 6.0468197386674e-49 -0.297418546307748 0.00599423951804285 miRNAWalker2_validate -0.151752314117167 3.08140035512846e-05 NA NA NA hsa-miR-335-3p WDR7 2.29463721765513 4.1956113745077e-18 -0.297418546307748 0.00599423951804285 mirMAP -0.126541470729617 3.2228536564061e-08 NA NA NA hsa-miR-21-5p WFS1 2.21515015440792 6.0468197386674e-49 -0.492565756614294 0.00737087241652513 miRNAWalker2_validate -0.381197160012256 3.64724592788954e-10 NA NA NA hsa-miR-200a-3p WIPF1 2.02394729844446 2.21240501925011e-08 -0.0481229578257576 0.794464532128527 MirTarget;miRNATAP -0.193284345351404 3.57008596447215e-11 NA NA NA hsa-miR-200b-3p WIPF1 2.06025765178663 3.07718049337497e-10 -0.0481229578257576 0.794464532128527 MirTarget;TargetScan -0.215326976518172 1.71865385162294e-11 NA NA NA hsa-miR-200b-3p WIPF3 2.06025765178663 3.07718049337497e-10 -1.35945672119358 0.000118862043671656 TargetScan -0.306665675655209 1.33529389426248e-06 NA NA NA hsa-miR-335-3p WIPF3 2.29463721765513 4.1956113745077e-18 -1.35945672119358 0.000118862043671656 mirMAP -0.420282703476509 2.71377040854442e-08 NA NA NA hsa-miR-935 WIPF3 2.321600496365 1.00042201726114e-07 -1.35945672119358 0.000118862043671656 miRNATAP -0.263932447064345 1.84486611288414e-07 NA NA NA hsa-miR-192-5p WNK1 2.0867723747501 3.57854249239079e-08 -0.0928178691135297 0.446606934438845 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.141712469582297 4.68841547031315e-15 NA NA NA hsa-miR-200a-3p WNK1 2.02394729844446 2.21240501925011e-08 -0.0928178691135297 0.446606934438845 MirTarget -0.114884198741975 3.10608273634756e-09 NA NA NA hsa-miR-200a-5p WNK1 2.19152245759943 3.17968183522514e-11 -0.0928178691135297 0.446606934438845 MirTarget;miRNATAP -0.119249517393489 1.52020137760279e-08 NA NA NA hsa-miR-146b-5p WNK3 2.23105707690238 3.83997814011313e-23 -0.566384750663729 0.0267756841098298 miRanda -0.310822107740271 7.75640519272655e-07 NA NA NA hsa-miR-200a-3p WNK3 2.02394729844446 2.21240501925011e-08 -0.566384750663729 0.0267756841098298 mirMAP -0.387733624479278 9.28539748003694e-24 NA NA NA hsa-miR-200b-3p WNK3 2.06025765178663 3.07718049337497e-10 -0.566384750663729 0.0267756841098298 TargetScan -0.399865177513822 1.13836539002506e-20 NA NA NA hsa-miR-21-5p WNK3 2.21515015440792 6.0468197386674e-49 -0.566384750663729 0.0267756841098298 miRNAWalker2_validate -0.371609508962061 1.60935349877209e-05 NA NA NA hsa-miR-146b-3p WNT16 2.08650140817622 5.3293570720033e-22 -0.576495177777264 0.11525756113286 MirTarget -0.228698119663276 0.0168448032364744 NA NA NA hsa-miR-200b-3p WNT16 2.06025765178663 3.07718049337497e-10 -0.576495177777264 0.11525756113286 MirTarget -0.180030136434788 0.00634285654731372 NA NA NA hsa-miR-135b-5p WSCD1 2.80066701698235 2.12546333413447e-11 -0.82755709042107 0.00201753753835117 mirMAP -0.209868040198172 6.45799654097273e-08 NA NA NA hsa-miR-192-5p WSCD1 2.0867723747501 3.57854249239079e-08 -0.82755709042107 0.00201753753835117 mirMAP -0.179964315658448 1.72822984303404e-05 NA NA NA hsa-miR-135b-5p WSCD2 2.80066701698235 2.12546333413447e-11 -2.94983357190553 4.37999379243908e-08 MirTarget -0.592608037400091 2.0322993718084e-14 NA NA NA hsa-miR-335-3p WSCD2 2.29463721765513 4.1956113745077e-18 -2.94983357190553 4.37999379243908e-08 mirMAP -0.943801551883457 6.13797096530838e-17 NA NA NA hsa-miR-146b-3p WTIP 2.08650140817622 5.3293570720033e-22 -0.203064079884611 0.334942845307838 mirMAP -0.161223681717763 0.0032388975504998 NA NA NA hsa-miR-183-5p WTIP 2.08412478942637 1.08931431254487e-10 -0.203064079884611 0.334942845307838 mirMAP -0.249225804018492 1.54814526556138e-11 NA NA NA hsa-miR-194-5p WTIP 2.24386881692218 9.35116329002209e-11 -0.203064079884611 0.334942845307838 mirMAP -0.183324514103442 1.63235914956465e-07 NA NA NA hsa-miR-200a-3p WTIP 2.02394729844446 2.21240501925011e-08 -0.203064079884611 0.334942845307838 mirMAP -0.264238100356434 6.08656839559055e-16 NA NA NA hsa-miR-92a-1-5p WTIP 2.04820501765632 9.32117486799495e-13 -0.203064079884611 0.334942845307838 mirMAP -0.211843982091844 8.07632798627037e-07 NA NA NA hsa-miR-1-3p WWC1 -2.73171785118192 3.4424534921136e-12 0.796945228817028 0.000310841257296447 MirTarget -0.165822565251313 3.71549812904283e-07 NA NA NA hsa-miR-146b-5p WWC2 2.23105707690238 3.83997814011313e-23 -0.178838877224607 0.274326089669387 MirTarget;PITA;miRanda;miRNATAP -0.121536423977642 0.00277390243406566 NA NA NA hsa-miR-192-5p WWC2 2.0867723747501 3.57854249239079e-08 -0.178838877224607 0.274326089669387 miRNAWalker2_validate -0.14740778103028 3.36627055735297e-09 NA NA NA hsa-miR-200a-3p WWC2 2.02394729844446 2.21240501925011e-08 -0.178838877224607 0.274326089669387 mirMAP -0.156836550732739 1.73939704911672e-09 NA NA NA hsa-miR-335-3p WWC2 2.29463721765513 4.1956113745077e-18 -0.178838877224607 0.274326089669387 mirMAP -0.126541246966576 0.000309610992422551 NA NA NA hsa-miR-146b-3p WWC3 2.08650140817622 5.3293570720033e-22 -0.16305955042508 0.336949478457286 MirTarget;PITA;miRNATAP -0.168479379368246 0.000122578327883293 NA NA NA hsa-miR-146b-5p WWC3 2.23105707690238 3.83997814011313e-23 -0.16305955042508 0.336949478457286 mirMAP -0.199602340832876 1.61046139071108e-06 NA NA NA hsa-miR-192-5p WWC3 2.0867723747501 3.57854249239079e-08 -0.16305955042508 0.336949478457286 miRNAWalker2_validate -0.242010157336886 3.85716005272087e-23 NA NA NA hsa-miR-200b-3p WWC3 2.06025765178663 3.07718049337497e-10 -0.16305955042508 0.336949478457286 MirTarget;TargetScan -0.292751821407836 4.52711450760642e-26 NA NA NA hsa-miR-18a-5p WWTR1 2.04701000113742 1.30593450319289e-12 -0.344530111808307 0.119970728404188 miRNAWalker2_validate -0.406755001122672 6.95966845412224e-23 NA NA NA hsa-miR-200a-3p WWTR1 2.02394729844446 2.21240501925011e-08 -0.344530111808307 0.119970728404188 MirTarget;miRNATAP -0.367446060760197 1.65732998017298e-29 NA NA NA hsa-miR-335-3p WWTR1 2.29463721765513 4.1956113745077e-18 -0.344530111808307 0.119970728404188 MirTarget -0.312127417069719 1.4111963502503e-11 NA NA NA hsa-miR-200a-3p XCR1 2.02394729844446 2.21240501925011e-08 -1.61257287902335 0.000127069136505422 mirMAP -0.146368889663074 0.0367654496919361 NA NA NA hsa-miR-335-3p XCR1 2.29463721765513 4.1956113745077e-18 -1.61257287902335 0.000127069136505422 mirMAP -0.323639679414815 0.000413121732914832 NA NA NA hsa-miR-200b-3p XG 2.06025765178663 3.07718049337497e-10 -1.10257355371225 0.0148334491987796 MirTarget -0.321810649271057 7.38034923520918e-05 NA NA NA hsa-miR-146b-5p XK 2.23105707690238 3.83997814011313e-23 -1.11942312531677 0.000227038768200687 miRanda -0.238832910111274 0.00176285434736359 NA NA NA hsa-miR-146b-5p XKR4 2.23105707690238 3.83997814011313e-23 -3.2550766725692 2.66020302369966e-10 miRanda -0.783034550334574 1.51113800279292e-09 NA NA NA hsa-miR-200b-3p XKR4 2.06025765178663 3.07718049337497e-10 -3.2550766725692 2.66020302369966e-10 MirTarget;TargetScan -0.918962368097352 8.61420278965142e-26 NA NA NA hsa-miR-335-3p XKR4 2.29463721765513 4.1956113745077e-18 -3.2550766725692 2.66020302369966e-10 mirMAP -0.979220560621646 9.46891760883188e-20 NA NA NA hsa-miR-183-5p XKR6 2.08412478942637 1.08931431254487e-10 -0.834048035532205 0.00301699280624388 miRNATAP -0.14568644603504 0.00469458278033194 NA NA NA hsa-miR-200b-3p XKR6 2.06025765178663 3.07718049337497e-10 -0.834048035532205 0.00301699280624388 TargetScan -0.156073840954401 0.0021502227989225 NA NA NA hsa-miR-21-5p XKR6 2.21515015440792 6.0468197386674e-49 -0.834048035532205 0.00301699280624388 MirTarget;miRNATAP -0.29560987217621 0.00205863538727814 NA NA NA hsa-miR-192-5p XPA 2.0867723747501 3.57854249239079e-08 -0.571355339471061 6.41096410445808e-08 miRNAWalker2_validate -0.104898666798798 1.5226334855311e-10 NA NA NA hsa-miR-133a-3p XPO4 -2.63342156915404 5.72661351480585e-12 0.716562273066413 1.10461475888557e-09 MirTarget -0.106436686803615 3.83570768152747e-09 NA NA NA hsa-miR-141-5p XYLT1 2.13747696823946 1.73124674554872e-11 -0.197036506362473 0.248263224443978 mirMAP -0.157196148471819 3.58412113687667e-07 NA NA NA hsa-miR-18a-5p XYLT1 2.04701000113742 1.30593450319289e-12 -0.197036506362473 0.248263224443978 MirTarget -0.151296762811731 9.00641589520653e-06 NA NA NA hsa-miR-92a-1-5p XYLT1 2.04820501765632 9.32117486799495e-13 -0.197036506362473 0.248263224443978 mirMAP -0.112755451408575 0.00137789366893497 NA NA NA hsa-miR-141-5p YAP1 2.13747696823946 1.73124674554872e-11 0.22036194497483 0.118363238667109 miRNATAP -0.10586567231999 3.93782524570315e-05 21289630 MicroRNA 141 confers resistance to cisplatin induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma; Furthermore we found that miR-141 directly targeted the 3'-untranslated region of YAP1 which is known to have a crucial role in apoptosis induced by DNA-damaging agents and thus downregulated YAP1 expression drug resistance esophageal cancer hsa-miR-200a-3p YAP1 2.02394729844446 2.21240501925011e-08 0.22036194497483 0.118363238667109 miRNAWalker2_validate;MirTarget -0.117592578563962 2.13977844197491e-07 23340296 MicroRNA 200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer; We identified Yes-associated protein 1 YAP1 as a novel target of miR-200a; Our data showed that targeting of YAP1 by miR-200a resulted in decreased expression of proapoptotic proteins which leads to anoikis resistance; Remarkably we found that YAP1 expression was inversely correlated with miR-200a expression in breast cancer clinical specimens and miR-200a expression was associated with distant metastasis in patients with breast cancer metastasis;drug resistance breast cancer hsa-miR-200b-3p YAP1 2.06025765178663 3.07718049337497e-10 0.22036194497483 0.118363238667109 MirTarget -0.104554911442379 3.13418468963523e-05 NA NA NA hsa-miR-146b-5p YPEL1 2.23105707690238 3.83997814011313e-23 -0.191540592356424 0.0956078951843983 mirMAP -0.106047731922186 0.000185377397112228 NA NA NA hsa-miR-200b-3p YPEL1 2.06025765178663 3.07718049337497e-10 -0.191540592356424 0.0956078951843983 MirTarget -0.126141921100061 2.83970941694086e-10 NA NA NA hsa-miR-146b-5p YPEL2 2.23105707690238 3.83997814011313e-23 -0.237176827406619 0.0273597290921733 miRanda -0.102050388088435 0.000120877499590501 NA NA NA hsa-miR-183-5p YPEL2 2.08412478942637 1.08931431254487e-10 -0.237176827406619 0.0273597290921733 mirMAP -0.130677811819061 3.62368182364306e-12 NA NA NA hsa-miR-21-5p YPEL2 2.21515015440792 6.0468197386674e-49 -0.237176827406619 0.0273597290921733 mirMAP -0.130975983905411 0.000299038102136112 NA NA NA hsa-miR-335-3p YPEL2 2.29463721765513 4.1956113745077e-18 -0.237176827406619 0.0273597290921733 mirMAP -0.121035800449818 9.96360714078141e-08 NA NA NA hsa-miR-183-5p YPEL5 2.08412478942637 1.08931431254487e-10 -0.858148561725122 1.02695114026619e-16 MirTarget;miRNATAP -0.202336978442207 8.67712066580809e-30 NA NA NA hsa-miR-18a-5p YPEL5 2.04701000113742 1.30593450319289e-12 -0.858148561725122 1.02695114026619e-16 miRNATAP -0.225946707724937 3.87999613182781e-30 NA NA NA hsa-miR-200a-3p YPEL5 2.02394729844446 2.21240501925011e-08 -0.858148561725122 1.02695114026619e-16 MirTarget;miRNATAP -0.168190041268252 1.15820439249076e-24 NA NA NA hsa-miR-935 YPEL5 2.321600496365 1.00042201726114e-07 -0.858148561725122 1.02695114026619e-16 MirTarget -0.135814222041834 2.14679413703971e-20 NA NA NA hsa-miR-21-5p ZADH2 2.21515015440792 6.0468197386674e-49 -0.352837585404997 0.000188320740050818 miRNAWalker2_validate;mirMAP -0.143578260685888 6.48558360273449e-06 NA NA NA hsa-miR-146b-5p ZBTB10 2.23105707690238 3.83997814011313e-23 0.11491226178643 0.650172271983559 mirMAP -0.239059210481664 0.000134832335283054 NA NA NA hsa-miR-192-5p ZBTB10 2.0867723747501 3.57854249239079e-08 0.11491226178643 0.650172271983559 miRNAWalker2_validate -0.203674259504496 1.65430198616637e-07 NA NA NA hsa-miR-200a-3p ZBTB10 2.02394729844446 2.21240501925011e-08 0.11491226178643 0.650172271983559 mirMAP -0.233941966681282 7.49781984676595e-09 NA NA NA hsa-miR-200b-3p ZBTB10 2.06025765178663 3.07718049337497e-10 0.11491226178643 0.650172271983559 MirTarget -0.265926436488073 1.9850732793045e-09 NA NA NA hsa-miR-335-3p ZBTB10 2.29463721765513 4.1956113745077e-18 0.11491226178643 0.650172271983559 MirTarget -0.155348440156184 0.00445274271985246 NA NA NA hsa-miR-200b-3p ZBTB16 2.06025765178663 3.07718049337497e-10 -2.91433902145166 3.46425121470516e-11 TargetScan -0.86148969433283 4.92164837141701e-32 NA NA NA hsa-miR-200a-3p ZBTB20 2.02394729844446 2.21240501925011e-08 -0.121915327498964 0.575686805536531 MirTarget -0.248259898560334 3.71502305093156e-13 NA NA NA hsa-miR-200b-3p ZBTB20 2.06025765178663 3.07718049337497e-10 -0.121915327498964 0.575686805536531 TargetScan -0.283541886018591 3.1220339678085e-14 NA NA NA hsa-miR-335-3p ZBTB20 2.29463721765513 4.1956113745077e-18 -0.121915327498964 0.575686805536531 mirMAP -0.254384111298241 3.10685677196158e-08 NA NA NA hsa-miR-200b-3p ZBTB38 2.06025765178663 3.07718049337497e-10 -0.113347911967603 0.309588302506711 TargetScan -0.110520294452932 1.47620611057896e-08 NA NA NA hsa-miR-335-3p ZBTB38 2.29463721765513 4.1956113745077e-18 -0.113347911967603 0.309588302506711 mirMAP -0.10422729962847 1.0948614028118e-05 NA NA NA hsa-miR-146b-3p ZBTB4 2.08650140817622 5.3293570720033e-22 -0.739035259086141 1.23899778598245e-07 miRNATAP -0.246997647572535 5.82232461174493e-12 NA NA NA hsa-miR-18a-5p ZBTB4 2.04701000113742 1.30593450319289e-12 -0.739035259086141 1.23899778598245e-07 MirTarget;miRNATAP -0.341866123856062 2.0956764699963e-44 NA NA NA hsa-miR-192-5p ZBTB4 2.0867723747501 3.57854249239079e-08 -0.739035259086141 1.23899778598245e-07 miRNATAP -0.223503453783292 1.37229732536078e-28 NA NA NA hsa-miR-18a-5p ZBTB47 2.04701000113742 1.30593450319289e-12 -0.487946101076992 0.00504998853219209 MirTarget -0.351731880530567 2.51968245194627e-28 NA NA NA hsa-miR-21-5p ZBTB47 2.21515015440792 6.0468197386674e-49 -0.487946101076992 0.00504998853219209 miRNAWalker2_validate -0.370960562758701 1.08270540506839e-10 NA NA NA hsa-miR-335-3p ZBTB7C 2.29463721765513 4.1956113745077e-18 -2.28016728197044 2.61876084523715e-08 mirMAP -0.351359454894017 0.000100958029116208 NA NA NA hsa-miR-935 ZBTB7C 2.321600496365 1.00042201726114e-07 -2.28016728197044 2.61876084523715e-08 mirMAP -0.172021287318301 0.0045933105554234 NA NA NA hsa-miR-146b-5p ZC3H12B 2.23105707690238 3.83997814011313e-23 -0.250832462540052 0.257150410374074 PITA;miRanda;miRNATAP -0.226307530998786 3.41424406273826e-05 NA NA NA hsa-miR-200b-3p ZC3H12B 2.06025765178663 3.07718049337497e-10 -0.250832462540052 0.257150410374074 mirMAP -0.115603057001352 0.00364999093076197 NA NA NA hsa-miR-18a-5p ZC3H12C 2.04701000113742 1.30593450319289e-12 -0.811123594545078 0.000172087654901931 MirTarget -0.223787485961424 2.51030749655233e-07 NA NA NA hsa-miR-192-5p ZC3H12C 2.0867723747501 3.57854249239079e-08 -0.811123594545078 0.000172087654901931 miRNAWalker2_validate -0.105730396043265 0.0019596486242818 NA NA NA hsa-miR-200a-3p ZC3H12C 2.02394729844446 2.21240501925011e-08 -0.811123594545078 0.000172087654901931 MirTarget -0.168107406462882 1.89553713431924e-06 NA NA NA hsa-miR-200a-5p ZC3H12C 2.19152245759943 3.17968183522514e-11 -0.811123594545078 0.000172087654901931 MirTarget;miRNATAP -0.182510951352255 1.81496269264177e-06 NA NA NA hsa-miR-200b-3p ZC3H12C 2.06025765178663 3.07718049337497e-10 -0.811123594545078 0.000172087654901931 TargetScan -0.194043905068367 5.12703872075676e-07 NA NA NA hsa-miR-335-3p ZC3H12C 2.29463721765513 4.1956113745077e-18 -0.811123594545078 0.000172087654901931 MirTarget;mirMAP -0.254329679750175 3.59373446041883e-08 NA NA NA hsa-miR-935 ZC3H12C 2.321600496365 1.00042201726114e-07 -0.811123594545078 0.000172087654901931 PITA -0.160379429251874 2.09074412445221e-07 NA NA NA hsa-miR-146b-5p ZC3H6 2.23105707690238 3.83997814011313e-23 -0.421092141864099 0.00728833157985793 PITA;miRanda;miRNATAP -0.177368902495261 4.68115946684282e-06 NA NA NA hsa-miR-192-5p ZC3H6 2.0867723747501 3.57854249239079e-08 -0.421092141864099 0.00728833157985793 MirTarget -0.184485182917819 3.67549508833325e-15 NA NA NA hsa-miR-194-5p ZC3H6 2.24386881692218 9.35116329002209e-11 -0.421092141864099 0.00728833157985793 mirMAP -0.15683341839291 1.58735273956605e-09 NA NA NA hsa-miR-200a-3p ZC3H6 2.02394729844446 2.21240501925011e-08 -0.421092141864099 0.00728833157985793 mirMAP -0.183899517249297 9.26088205171058e-14 NA NA NA hsa-miR-200b-3p ZC3H6 2.06025765178663 3.07718049337497e-10 -0.421092141864099 0.00728833157985793 MirTarget;TargetScan -0.192624167520686 1.50696114427257e-12 NA NA NA hsa-miR-335-3p ZC3H6 2.29463721765513 4.1956113745077e-18 -0.421092141864099 0.00728833157985793 MirTarget -0.183860025562717 3.30913482002541e-08 NA NA NA hsa-miR-935 ZC3H6 2.321600496365 1.00042201726114e-07 -0.421092141864099 0.00728833157985793 PITA;miRNATAP -0.17371439247182 6.56922211997892e-16 NA NA NA hsa-miR-146b-5p ZC4H2 2.23105707690238 3.83997814011313e-23 -0.886422868342888 9.91992143040442e-07 miRanda -0.271201689819488 1.41530140893099e-09 NA NA NA hsa-miR-92a-1-5p ZC4H2 2.04820501765632 9.32117486799495e-13 -0.886422868342888 9.91992143040442e-07 MirTarget -0.175558809355089 3.45538162175772e-06 NA NA NA hsa-miR-135b-5p ZCCHC24 2.80066701698235 2.12546333413447e-11 -0.738590343521926 0.00346932529454311 MirTarget -0.305367690554584 2.81048221325202e-18 NA NA NA hsa-miR-18a-5p ZCCHC24 2.04701000113742 1.30593450319289e-12 -0.738590343521926 0.00346932529454311 MirTarget -0.513374909610353 1.50594216939862e-28 NA NA NA hsa-miR-200a-3p ZCCHC24 2.02394729844446 2.21240501925011e-08 -0.738590343521926 0.00346932529454311 MirTarget;miRNATAP -0.470298125479702 5.48567071880065e-39 NA NA NA hsa-miR-200b-3p ZCCHC24 2.06025765178663 3.07718049337497e-10 -0.738590343521926 0.00346932529454311 MirTarget;TargetScan -0.507821192062702 2.61547608277397e-37 NA NA NA hsa-miR-335-3p ZCCHC24 2.29463721765513 4.1956113745077e-18 -0.738590343521926 0.00346932529454311 MirTarget -0.426741950766347 2.14738832885559e-16 NA NA NA hsa-miR-194-5p ZCCHC5 2.24386881692218 9.35116329002209e-11 -0.953061160218104 0.0518339911676993 miRNATAP -0.580487263650328 3.70378383188755e-13 NA NA NA hsa-miR-335-3p ZDBF2 2.29463721765513 4.1956113745077e-18 -0.997539235517089 0.000245651993154949 MirTarget -0.364385497891746 2.58783214932813e-10 NA NA NA hsa-miR-183-5p ZDHHC15 2.08412478942637 1.08931431254487e-10 -1.35902684957062 3.39400626126344e-06 miRNATAP -0.571366920913828 1.43268138528902e-32 NA NA NA hsa-miR-18a-5p ZDHHC15 2.04701000113742 1.30593450319289e-12 -1.35902684957062 3.39400626126344e-06 MirTarget -0.559475372304131 4.53820589357792e-24 NA NA NA hsa-miR-200a-3p ZDHHC15 2.02394729844446 2.21240501925011e-08 -1.35902684957062 3.39400626126344e-06 MirTarget -0.499824041994878 2.52853562812963e-30 NA NA NA hsa-miR-200b-3p ZDHHC15 2.06025765178663 3.07718049337497e-10 -1.35902684957062 3.39400626126344e-06 MirTarget -0.530383052931637 6.16205997778021e-28 NA NA NA hsa-miR-335-3p ZDHHC15 2.29463721765513 4.1956113745077e-18 -1.35902684957062 3.39400626126344e-06 mirMAP -0.467244200062838 2.86557117363377e-14 NA NA NA hsa-miR-200b-3p ZDHHC17 2.06025765178663 3.07718049337497e-10 0.149454217669535 0.211398255202947 MirTarget;TargetScan -0.123966915831086 2.91087044370823e-09 NA NA NA hsa-miR-183-5p ZEB1 2.08412478942637 1.08931431254487e-10 -0.474334019913817 0.0476440408394034 MirTarget;miRNATAP -0.5245177905304 2.08235485763116e-46 NA NA NA hsa-miR-194-5p ZEB1 2.24386881692218 9.35116329002209e-11 -0.474334019913817 0.0476440408394034 miRNATAP -0.356057927338613 3.95655952076654e-21 NA NA NA hsa-miR-200a-3p ZEB1 2.02394729844446 2.21240501925011e-08 -0.474334019913817 0.0476440408394034 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.451673396814164 6.48579234036771e-41 27402864;27402080;23743934;24815002;24424572;20473948;19854497;26887977;24390222;26242262;19544444;23626803;24037528 This circuit comprises the microRNA 200 miR-200 family ZEB1 and GRHL2;Conversely ectopic expression of miR-200 inhibited this sprouting by indirectly reducing the protein levels of PDGFRβ through the direct suppression of ZEB1;This finding was accompanied by a sharp downregulation in the expression of the miR-200 family of microRNAs well-known targets of ZEB1;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;ZEB1 is also known to repress miR-200c-141 transcription in a negative feedback loop but otherwise little is known about the transcriptional regulation of the miR-200 family and miR-205;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;GRHL2 miR 200 ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification;Inhibition of ZEB1 by miR 200 characterizes Helicobacter pylori positive gastric diffuse large B cell lymphoma with a less aggressive behavior; Through genome-wide expression profiles of both miRNAs and mRNAs in nine H pylori-positive and nine H pylori-negative gastric diffuse large B-cell lymphomas we identified inhibition of ZEB1 zinc-finger E-box-binding homeobox 1 by miR-200 in H pylori-positive gastric diffuse large B-cell lymphomas; In 30 H pylori-positive and 30 H pylori-negative gastric diffuse large B-cell lymphomas we confirmed that H pylori-positive gastric diffuse large B-cell lymphomas had higher levels of miR-200 by qRT-PCR and lower levels of ZEB1 and higher levels of BCL6 using immunohistochemistry;MiR 200 suppresses metastases of colorectal cancer through ZEB1; Here we showed that the levels of miR-200 were significantly decreased and the levels of ZEB1 were significantly increased in the CRC specimens from patients compared to the paired non-tumor tissue; Moreover the levels of miR-200 and ZEB1 are inversely correlated; Bioinformatics analyses showed that miR-200 targeted the 3'-UTR of ZEB1 mRNA to inhibit its translation which was confirmed by luciferase reporter assay;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;Concomitant with miR-200 decrease there was an increase in ZEB1 mRNA expression;MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways ;;;;tumorigenesis;;;;;metastasis;;;metastasis sarcoma;breast cancer;endometrial cancer;sarcoma;head and neck cancer;bladder cancer;ovarian cancer;ovarian cancer;B cell lymphoma;colorectal cancer;prostate cancer;breast cancer;breast cancer hsa-miR-200b-3p ZEB1 2.06025765178663 3.07718049337497e-10 -0.474334019913817 0.0476440408394034 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.486888008854174 6.10126603219397e-39 24352645;27402864;27402080;23743934;24815002;24424572;20473948;26011542;19854497;26887977;24390222;27307751;26242262;19544444;23626803;26783187;24037528 Functional experiments demonstrated that miR-200b suppressed ZEB1 augmented E-cadherin inhibited cell migration and suppressed tumor growth in a mouse model;This circuit comprises the microRNA 200 miR-200 family ZEB1 and GRHL2;Conversely ectopic expression of miR-200 inhibited this sprouting by indirectly reducing the protein levels of PDGFRβ through the direct suppression of ZEB1;This finding was accompanied by a sharp downregulation in the expression of the miR-200 family of microRNAs well-known targets of ZEB1;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;ZEB1 is also known to repress miR-200c-141 transcription in a negative feedback loop but otherwise little is known about the transcriptional regulation of the miR-200 family and miR-205;Here we show that 53BP1 negatively regulated EMT by modulating ZEB1 through targeting microRNA miR-200b and miR-429; In 18 clinical tissue samples expression of 53BP1 was positively correlated with miR-200b and mir-429 and negatively correlated with ZEB1;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;GRHL2 miR 200 ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification;Inhibition of ZEB1 by miR 200 characterizes Helicobacter pylori positive gastric diffuse large B cell lymphoma with a less aggressive behavior; Through genome-wide expression profiles of both miRNAs and mRNAs in nine H pylori-positive and nine H pylori-negative gastric diffuse large B-cell lymphomas we identified inhibition of ZEB1 zinc-finger E-box-binding homeobox 1 by miR-200 in H pylori-positive gastric diffuse large B-cell lymphomas; In 30 H pylori-positive and 30 H pylori-negative gastric diffuse large B-cell lymphomas we confirmed that H pylori-positive gastric diffuse large B-cell lymphomas had higher levels of miR-200 by qRT-PCR and lower levels of ZEB1 and higher levels of BCL6 using immunohistochemistry;MicroRNA 200b acts as a tumor suppressor in osteosarcoma via targeting ZEB1; Moreover ZEB1 was identified as a target gene of miR-200b and its expression levels were negatively mediated by miR-200b in osteosarcoma cells; Based on these findings our study suggests that miR-200b inhibits the proliferation migration and invasion of osteosarcoma cells probably via the inhibition of ZEB1 expression;MiR 200 suppresses metastases of colorectal cancer through ZEB1; Here we showed that the levels of miR-200 were significantly decreased and the levels of ZEB1 were significantly increased in the CRC specimens from patients compared to the paired non-tumor tissue; Moreover the levels of miR-200 and ZEB1 are inversely correlated; Bioinformatics analyses showed that miR-200 targeted the 3'-UTR of ZEB1 mRNA to inhibit its translation which was confirmed by luciferase reporter assay;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;Concomitant with miR-200 decrease there was an increase in ZEB1 mRNA expression; Concomitant with the increase in miR-200b and miR-200c ZEB1 expression was decreased and cells appeared more epithelial in morphology and were sensitized to TAM and fulvestrant inhibition;Nintedanib was able to reverse TGF-β1-induced EMT and resistance to gefitinib caused by miR-200b and miR-141 upregulation and ZEB1 downregulation;MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways cell migration;;;;;tumorigenesis;;;;;;;metastasis;;;drug resistance;metastasis gastric cancer;sarcoma;breast cancer;endometrial cancer;sarcoma;head and neck cancer;bladder cancer;breast cancer;ovarian cancer;ovarian cancer;B cell lymphoma;sarcoma;colorectal cancer;prostate cancer;breast cancer;lung squamous cell cancer;breast cancer hsa-miR-335-3p ZEB1 2.29463721765513 4.1956113745077e-18 -0.474334019913817 0.0476440408394034 MirTarget;mirMAP -0.404204612647789 1.58279022084438e-16 NA NA NA hsa-miR-183-5p ZEB2 2.08412478942637 1.08931431254487e-10 -0.365164555864173 0.0476046539874367 MirTarget;miRNATAP -0.309037358689492 1.27632120716603e-23 NA NA NA hsa-miR-192-5p ZEB2 2.0867723747501 3.57854249239079e-08 -0.365164555864173 0.0476046539874367 MirTarget;miRNATAP -0.188437870681729 1.44729016751678e-11 NA NA NA hsa-miR-200a-3p ZEB2 2.02394729844446 2.21240501925011e-08 -0.365164555864173 0.0476046539874367 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.258941895617459 3.90063580596047e-20 24518294;19787069;24815002;24424572;19854497;21529905;19544444;25797260 This switch involved activation of the transforming growth factor-β TGFβ signaling network that led to a shift in the balance between miR-200 microRNAs and the transcription factor zinc finger E-box-binding homeobox 2 ZEB2 resulting in suppressed transcription of the gene encoding E-cadherin;These findings are surprising since the miR-200 family was previously shown to promote epithelial characteristics by inhibiting the transcriptional repressor Zeb2 and thereby enhancing E-cadherin expression; Expression of miR-200 which promotes a mesenchymal to epithelial cell transition MET by inhibiting Zeb2 expression unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;MicroRNA 200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E cadherin repressor ZEB2; The 3'-UTR of ZEB2 mRNA a transcriptional repressor of E-cadherin was found to be regulated directly by miR-200a; Our results suggest that loss of expression of miR-200a may play a critical role in the repression of E-cadherin by ZEB2 thereby enhancing migration and invasion in CD133/1+ cells;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;MicroRNA 200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2; Overexpression of miR-200a in SP cells decreased metastasis-related markers and expression of ZEB2; The associations between miR-200a SP cells and ZEB2 were validated in HCC; These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2 ;metastasis;;tumorigenesis;;;;metastasis breast cancer;breast cancer;sarcoma;head and neck cancer;ovarian cancer;ovarian cancer;prostate cancer;liver cancer hsa-miR-200a-5p ZEB2 2.19152245759943 3.17968183522514e-11 -0.365164555864173 0.0476046539874367 miRNATAP -0.260025628843105 4.08085667512753e-17 24518294;19787069;24815002;24424572;19854497;21529905;19544444;25797260 This switch involved activation of the transforming growth factor-β TGFβ signaling network that led to a shift in the balance between miR-200 microRNAs and the transcription factor zinc finger E-box-binding homeobox 2 ZEB2 resulting in suppressed transcription of the gene encoding E-cadherin;These findings are surprising since the miR-200 family was previously shown to promote epithelial characteristics by inhibiting the transcriptional repressor Zeb2 and thereby enhancing E-cadherin expression; Expression of miR-200 which promotes a mesenchymal to epithelial cell transition MET by inhibiting Zeb2 expression unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;MicroRNA 200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E cadherin repressor ZEB2; The 3'-UTR of ZEB2 mRNA a transcriptional repressor of E-cadherin was found to be regulated directly by miR-200a; Our results suggest that loss of expression of miR-200a may play a critical role in the repression of E-cadherin by ZEB2 thereby enhancing migration and invasion in CD133/1+ cells;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;MicroRNA 200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2; Overexpression of miR-200a in SP cells decreased metastasis-related markers and expression of ZEB2; The associations between miR-200a SP cells and ZEB2 were validated in HCC; These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2 ;metastasis;;tumorigenesis;;;;metastasis breast cancer;breast cancer;sarcoma;head and neck cancer;ovarian cancer;ovarian cancer;prostate cancer;liver cancer hsa-miR-200b-3p ZEB2 2.06025765178663 3.07718049337497e-10 -0.365164555864173 0.0476046539874367 miRNAWalker2_validate;miRTarBase;MirTarget -0.270934795672967 3.64130357556405e-18 22311119;24518294;19787069;24815002;24424572;24769353;19854497;19544444 MicroRNA 200b regulates cell proliferation invasion and migration by directly targeting ZEB2 in gastric carcinoma; There was a strong correlation between the levels of miR-200b and ZEB2 and E-cadherin mRNAs in gastric cancer patients; miR-200b regulates ZEB2 expression and thus controls metastasis in gastric cancer;This switch involved activation of the transforming growth factor-β TGFβ signaling network that led to a shift in the balance between miR-200 microRNAs and the transcription factor zinc finger E-box-binding homeobox 2 ZEB2 resulting in suppressed transcription of the gene encoding E-cadherin;These findings are surprising since the miR-200 family was previously shown to promote epithelial characteristics by inhibiting the transcriptional repressor Zeb2 and thereby enhancing E-cadherin expression; Expression of miR-200 which promotes a mesenchymal to epithelial cell transition MET by inhibiting Zeb2 expression unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;Zinc finger E box binding homeobox 2 ZEB2 regulated by miR 200b contributes to multi drug resistance of small cell lung cancer; In silico analysis demonstrated that there are complementary binding sites between miR-200b and ZEB2 3'-UTR and identified miR-200b as a potential regulator of ZEB2; Overexpression of miR-200b led to the downregulation of ZEB2 at protein level; Luciferase reporter gene assay showed that 3'UTR ZEB2 activity was regulated by miR-200b; Our results suggest that ZEB2 modulates drug resistance and is regulated by miR-200b;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2 metastasis;;metastasis;;tumorigenesis;drug resistance;; gastric cancer;breast cancer;breast cancer;sarcoma;head and neck cancer;lung squamous cell cancer;ovarian cancer;prostate cancer hsa-miR-146b-5p ZFAND5 2.23105707690238 3.83997814011313e-23 -0.409420327651102 4.50112739233377e-05 miRanda -0.137966874625626 2.18004960102263e-08 NA NA NA hsa-miR-18a-5p ZFAND5 2.04701000113742 1.30593450319289e-12 -0.409420327651102 4.50112739233377e-05 miRNAWalker2_validate -0.139892207456502 1.12301628705601e-12 NA NA NA hsa-miR-200a-5p ZFAND5 2.19152245759943 3.17968183522514e-11 -0.409420327651102 4.50112739233377e-05 mirMAP -0.154670848645158 2.27015092787833e-20 NA NA NA hsa-miR-200b-3p ZFAND5 2.06025765178663 3.07718049337497e-10 -0.409420327651102 4.50112739233377e-05 TargetScan;mirMAP -0.147293298653332 7.58162422760474e-18 NA NA NA hsa-miR-335-3p ZFAND5 2.29463721765513 4.1956113745077e-18 -0.409420327651102 4.50112739233377e-05 mirMAP -0.10340150482482 1.5734646114951e-06 NA NA NA hsa-miR-200a-3p ZFHX2 2.02394729844446 2.21240501925011e-08 0.178054950141668 0.331411538778422 mirMAP -0.117777082731148 7.60949129574227e-05 NA NA NA hsa-miR-194-5p ZFHX3 2.24386881692218 9.35116329002209e-11 0.388625553932512 0.0136343956376204 MirTarget;miRNATAP -0.155714612246324 2.36553048315844e-09 NA NA NA hsa-miR-200a-3p ZFHX3 2.02394729844446 2.21240501925011e-08 0.388625553932512 0.0136343956376204 miRNATAP -0.185806043620393 5.78590103623098e-14 NA NA NA hsa-miR-146b-5p ZFHX4 2.23105707690238 3.83997814011313e-23 0.0184972294773713 0.955736809911936 miRanda -0.274940467848202 0.000880778196921548 NA NA NA hsa-miR-183-5p ZFHX4 2.08412478942637 1.08931431254487e-10 0.0184972294773713 0.955736809911936 miRNAWalker2_validate -0.503861543295932 6.56226597412138e-19 NA NA NA hsa-miR-194-5p ZFHX4 2.24386881692218 9.35116329002209e-11 0.0184972294773713 0.955736809911936 MirTarget;miRNATAP -0.363564065668505 2.60063111881759e-11 NA NA NA hsa-miR-200b-3p ZFHX4 2.06025765178663 3.07718049337497e-10 0.0184972294773713 0.955736809911936 TargetScan -0.48709569890708 4.86258543242825e-18 NA NA NA hsa-miR-335-3p ZFHX4 2.29463721765513 4.1956113745077e-18 0.0184972294773713 0.955736809911936 MirTarget;mirMAP -0.282250583546199 7.62253923728465e-05 NA NA NA hsa-miR-192-5p ZFP1 2.0867723747501 3.57854249239079e-08 0.170647763782241 0.0848812036527689 miRNAWalker2_validate -0.137080260254138 8.12689551191585e-22 NA NA NA hsa-miR-141-5p ZFP14 2.13747696823946 1.73124674554872e-11 0.236123364296766 0.105798327877095 MirTarget -0.11575931788846 1.35268513039748e-05 NA NA NA hsa-miR-146b-5p ZFP28 2.23105707690238 3.83997814011313e-23 -1.25578595410858 9.28635287695684e-07 miRanda -0.416523126129061 3.68358618700382e-11 NA NA NA hsa-miR-335-3p ZFP28 2.29463721765513 4.1956113745077e-18 -1.25578595410858 9.28635287695684e-07 MirTarget;mirMAP -0.442379551537643 1.08939213364616e-16 NA NA NA hsa-miR-146b-5p ZFP3 2.23105707690238 3.83997814011313e-23 -0.823634074896517 0.000143178407035836 miRanda -0.253626096254964 2.47603341916964e-06 NA NA NA hsa-miR-192-5p ZFP30 2.0867723747501 3.57854249239079e-08 -0.019514163754248 0.929402972344817 miRNAWalker2_validate -0.14062593692418 3.80093627917942e-05 NA NA NA hsa-miR-146b-5p ZFP36 2.23105707690238 3.83997814011313e-23 -1.41190121652751 3.70099987646267e-12 miRanda -0.33845042476289 3.4354683036413e-11 NA NA NA hsa-miR-192-5p ZFP36L1 2.0867723747501 3.57854249239079e-08 -0.505376196486477 8.0934102333684e-05 mirMAP -0.143072557544321 1.75494302240322e-13 NA NA NA hsa-miR-200a-3p ZFP37 2.02394729844446 2.21240501925011e-08 -0.21724276710313 0.296313629252117 mirMAP -0.174208395921764 1.88683186210358e-07 NA NA NA hsa-miR-200b-3p ZFP37 2.06025765178663 3.07718049337497e-10 -0.21724276710313 0.296313629252117 mirMAP -0.175795430247456 1.84419732614148e-06 NA NA NA hsa-miR-935 ZFP37 2.321600496365 1.00042201726114e-07 -0.21724276710313 0.296313629252117 miRNAWalker2_validate -0.121590551798104 4.19249560787618e-05 NA NA NA hsa-miR-146b-5p ZFPM2 2.23105707690238 3.83997814011313e-23 -0.936440499022908 0.00110696573568431 miRanda -0.429463727656431 9.25021737910173e-10 NA NA NA hsa-miR-183-5p ZFPM2 2.08412478942637 1.08931431254487e-10 -0.936440499022908 0.00110696573568431 miRNATAP -0.574320903632048 1.50643513311464e-35 NA NA NA hsa-miR-200a-3p ZFPM2 2.02394729844446 2.21240501925011e-08 -0.936440499022908 0.00110696573568431 miRNAWalker2_validate;miRTarBase -0.524500925681918 6.79251172542736e-37 26314828 It was reported that miR-200 can activate PI3K/AKT by targeting FOG2 friend of GATA 2 which directly binds to the p85α regulatory subunit of PI3K lung cancer hsa-miR-200b-3p ZFPM2 2.06025765178663 3.07718049337497e-10 -0.936440499022908 0.00110696573568431 miRNAWalker2_validate;miRTarBase;TargetScan -0.563191699295219 7.81638009550403e-35 26314828 It was reported that miR-200 can activate PI3K/AKT by targeting FOG2 friend of GATA 2 which directly binds to the p85α regulatory subunit of PI3K lung cancer hsa-miR-335-3p ZFY 2.29463721765513 4.1956113745077e-18 -0.904040008651671 0.308441013741214 MirTarget -0.5367536199273 0.00511886409668306 NA NA NA hsa-miR-146b-5p ZFYVE1 2.23105707690238 3.83997814011313e-23 -0.662930192090126 1.00517576029795e-12 miRNATAP -0.161431383428674 3.3502236925119e-12 NA NA NA hsa-miR-192-5p ZFYVE1 2.0867723747501 3.57854249239079e-08 -0.662930192090126 1.00517576029795e-12 mirMAP -0.106215455828659 2.50951646462263e-13 NA NA NA hsa-miR-135b-5p ZHX3 2.80066701698235 2.12546333413447e-11 -0.48569389286767 0.00067184703404714 mirMAP -0.145094859813254 7.89750945098995e-13 NA NA NA hsa-miR-146b-5p ZHX3 2.23105707690238 3.83997814011313e-23 -0.48569389286767 0.00067184703404714 mirMAP -0.271383795674609 1.45911040997647e-15 NA NA NA hsa-miR-18a-5p ZHX3 2.04701000113742 1.30593450319289e-12 -0.48569389286767 0.00067184703404714 mirMAP -0.211507786708913 2.54948375521147e-14 NA NA NA hsa-miR-146b-5p ZIC1 2.23105707690238 3.83997814011313e-23 -0.00280595979734599 0.996236581215562 PITA;miRanda -0.38001770927738 0.0103677608308479 NA NA NA hsa-miR-200a-3p ZIK1 2.02394729844446 2.21240501925011e-08 -0.913583168024905 9.87197126971247e-05 mirMAP -0.341680741739383 2.97065840559019e-21 NA NA NA hsa-miR-183-5p ZKSCAN3 2.08412478942637 1.08931431254487e-10 -0.109676052920737 0.337932368652992 MirTarget -0.107958118851834 1.09788809966503e-07 NA NA NA hsa-miR-192-5p ZMAT3 2.0867723747501 3.57854249239079e-08 0.27771952020038 0.0499447683089053 miRNAWalker2_validate;MirTarget -0.107130302776379 9.38039268345691e-07 NA NA NA hsa-miR-192-5p ZMYND11 2.0867723747501 3.57854249239079e-08 -0.200269385015078 0.0544853551345854 miRNAWalker2_validate -0.12223719372149 2.50274850314908e-15 NA NA NA hsa-miR-146b-5p ZNF10 2.23105707690238 3.83997814011313e-23 -0.363001485927109 0.0557184232876633 MirTarget;miRanda -0.190950340705597 4.70213836165844e-05 NA NA NA hsa-miR-335-3p ZNF10 2.29463721765513 4.1956113745077e-18 -0.363001485927109 0.0557184232876633 mirMAP -0.148787333431266 0.000265276577254282 NA NA NA hsa-miR-133a-3p ZNF131 -2.63342156915404 5.72661351480585e-12 0.52099493907426 4.47432655184721e-07 MirTarget -0.107021140740765 4.63147339641029e-12 NA NA NA hsa-miR-141-5p ZNF132 2.13747696823946 1.73124674554872e-11 -0.813255563754785 5.54763387920634e-07 miRNATAP -0.203460069354787 4.90300575984265e-12 NA NA NA hsa-miR-135b-5p ZNF135 2.80066701698235 2.12546333413447e-11 -1.19213360071235 4.12529858646068e-06 MirTarget -0.349735744548236 1.03508583034035e-22 NA NA NA hsa-miR-146b-5p ZNF141 2.23105707690238 3.83997814011313e-23 -0.514814121068054 0.0319523225732036 miRanda -0.20794276511536 0.000495019293540243 NA NA NA hsa-miR-335-3p ZNF141 2.29463721765513 4.1956113745077e-18 -0.514814121068054 0.0319523225732036 mirMAP -0.163031506005761 0.00166774728461578 NA NA NA hsa-miR-183-5p ZNF154 2.08412478942637 1.08931431254487e-10 -0.187654763140952 0.363532611120756 mirMAP -0.356735887268033 1.90836672188075e-25 NA NA NA hsa-miR-335-3p ZNF154 2.29463721765513 4.1956113745077e-18 -0.187654763140952 0.363532611120756 mirMAP -0.234446618075942 7.87497911570524e-08 NA NA NA hsa-miR-21-5p ZNF208 2.21515015440792 6.0468197386674e-49 -0.399746037206683 0.223810577491618 mirMAP -0.236989606180531 0.0341632619880181 NA NA NA hsa-miR-335-3p ZNF208 2.29463721765513 4.1956113745077e-18 -0.399746037206683 0.223810577491618 MirTarget;mirMAP -0.357883397601345 2.8798411659349e-07 NA NA NA hsa-miR-146b-3p ZNF219 2.08650140817622 5.3293570720033e-22 -0.630566053231792 1.10055128772359e-05 PITA -0.192209653302287 2.45522437818701e-07 NA NA NA hsa-miR-146b-5p ZNF229 2.23105707690238 3.83997814011313e-23 -1.39851759403425 1.4750088840847e-05 miRanda -0.345792163028269 1.9357868821781e-05 NA NA NA hsa-miR-146b-5p ZNF248 2.23105707690238 3.83997814011313e-23 -0.0574258532196534 0.651465511774278 miRanda -0.101691141574705 0.00121727875834524 NA NA NA hsa-miR-192-5p ZNF248 2.0867723747501 3.57854249239079e-08 -0.0574258532196534 0.651465511774278 miRNAWalker2_validate -0.165013462263238 5.88020534617679e-19 NA NA NA hsa-miR-194-5p ZNF25 2.24386881692218 9.35116329002209e-11 -0.516010020524319 0.00115089124104741 miRNATAP -0.26416090312245 5.01481596198479e-27 NA NA NA hsa-miR-335-3p ZNF25 2.29463721765513 4.1956113745077e-18 -0.516010020524319 0.00115089124104741 mirMAP -0.252692359762934 1.5728205107759e-14 NA NA NA hsa-miR-146b-5p ZNF254 2.23105707690238 3.83997814011313e-23 -0.163078671895383 0.389588344600487 miRanda -0.124442650689026 0.00833229312378564 NA NA NA hsa-miR-335-3p ZNF257 2.29463721765513 4.1956113745077e-18 -0.415022205907716 0.20129993638385 mirMAP -0.260939386383519 0.000183101834200188 NA NA NA hsa-miR-335-3p ZNF268 2.29463721765513 4.1956113745077e-18 -0.27657033789644 0.091605461930643 mirMAP -0.10216045313757 0.00386891585432039 NA NA NA hsa-miR-200b-3p ZNF280B 2.06025765178663 3.07718049337497e-10 0.143026327729279 0.631308702443122 mirMAP -0.163349912613203 0.00225589176453518 NA NA NA hsa-miR-146b-5p ZNF280D 2.23105707690238 3.83997814011313e-23 -0.197805598241113 0.0647624600534052 miRanda -0.135833439835185 1.9604606786786e-07 NA NA NA hsa-miR-21-5p ZNF280D 2.21515015440792 6.0468197386674e-49 -0.197805598241113 0.0647624600534052 mirMAP -0.129487267732276 0.000327108944918686 NA NA NA hsa-miR-335-3p ZNF280D 2.29463721765513 4.1956113745077e-18 -0.197805598241113 0.0647624600534052 mirMAP -0.110980349333381 1.01168748008735e-06 NA NA NA hsa-miR-335-3p ZNF287 2.29463721765513 4.1956113745077e-18 -0.809186183582229 3.39160236451578e-05 mirMAP -0.277238589674688 1.84324888111107e-11 NA NA NA hsa-miR-335-3p ZNF300 2.29463721765513 4.1956113745077e-18 -0.28263781781012 0.284966307597519 mirMAP -0.177982894348456 0.00177585933096203 NA NA NA hsa-miR-146b-5p ZNF32 2.23105707690238 3.83997814011313e-23 -0.468015068745106 0.000493150060293566 miRanda -0.167367867367032 4.39502611125355e-07 NA NA NA hsa-miR-335-3p ZNF32 2.29463721765513 4.1956113745077e-18 -0.468015068745106 0.000493150060293566 MirTarget -0.149517598886563 1.85443498261019e-07 NA NA NA hsa-miR-200a-3p ZNF329 2.02394729844446 2.21240501925011e-08 -0.422795120399759 0.0186656228976777 mirMAP -0.136918119988824 2.61219514435123e-06 NA NA NA hsa-miR-146b-5p ZNF331 2.23105707690238 3.83997814011313e-23 -1.25144163873366 6.15611673508242e-08 miRanda -0.307381925145737 1.13268446381494e-07 NA NA NA hsa-miR-335-3p ZNF331 2.29463721765513 4.1956113745077e-18 -1.25144163873366 6.15611673508242e-08 mirMAP -0.329235078936024 2.8784440288672e-11 NA NA NA hsa-miR-146b-5p ZNF333 2.23105707690238 3.83997814011313e-23 -0.127253811322877 0.334730689269716 miRanda -0.150919113758017 2.9924193664616e-06 NA NA NA hsa-miR-335-3p ZNF333 2.29463721765513 4.1956113745077e-18 -0.127253811322877 0.334730689269716 mirMAP -0.123189240138368 1.1440952528855e-05 NA NA NA hsa-miR-335-3p ZNF347 2.29463721765513 4.1956113745077e-18 -0.536501032509485 0.0273580400111318 mirMAP -0.282900101555018 4.10437678746735e-08 NA NA NA hsa-miR-335-3p ZNF354C 2.29463721765513 4.1956113745077e-18 -0.968356214536449 0.000383478594843384 mirMAP -0.413099133016291 4.53991265270597e-13 NA NA NA hsa-miR-200b-3p ZNF362 2.06025765178663 3.07718049337497e-10 -0.231025493088191 0.0584071488986172 TargetScan -0.200793924424658 2.1400571543582e-23 NA NA NA hsa-miR-146b-5p ZNF365 2.23105707690238 3.83997814011313e-23 0.197703399755446 0.570502929787385 miRanda;miRNATAP -0.266767613212984 0.00206693525840518 NA NA NA hsa-miR-18a-5p ZNF365 2.04701000113742 1.30593450319289e-12 0.197703399755446 0.570502929787385 MirTarget -0.383921795907416 2.53619395385033e-08 NA NA NA hsa-miR-200b-3p ZNF365 2.06025765178663 3.07718049337497e-10 0.197703399755446 0.570502929787385 TargetScan -0.378679051297217 4.88003490795333e-10 NA NA NA hsa-miR-335-3p ZNF365 2.29463721765513 4.1956113745077e-18 0.197703399755446 0.570502929787385 MirTarget -0.187798808999981 0.012636795118251 NA NA NA hsa-miR-135b-5p ZNF385B 2.80066701698235 2.12546333413447e-11 -2.04206623220296 7.71685969426973e-08 MirTarget -0.395237805647293 6.14320602620366e-13 NA NA NA hsa-miR-146b-5p ZNF385B 2.23105707690238 3.83997814011313e-23 -2.04206623220296 7.71685969426973e-08 miRanda -0.550072393120626 6.59959003553797e-09 NA NA NA hsa-miR-192-5p ZNF385B 2.0867723747501 3.57854249239079e-08 -2.04206623220296 7.71685969426973e-08 miRNAWalker2_validate -0.377806353523122 1.80778449563247e-10 NA NA NA hsa-miR-196a-5p ZNF385B 5.05945965885472 4.48343841468539e-25 -2.04206623220296 7.71685969426973e-08 MirTarget;miRNATAP -0.255149393959892 5.60768147433606e-09 NA NA NA hsa-miR-196b-5p ZNF385B 4.51951031652328 7.04026169031626e-18 -2.04206623220296 7.71685969426973e-08 MirTarget;miRNATAP -0.220877048934636 1.03954088982859e-07 NA NA NA hsa-miR-200a-3p ZNF385D 2.02394729844446 2.21240501925011e-08 -0.935708736484975 0.00238418130122692 MirTarget -0.500593948767522 1.2462744693615e-27 NA NA NA hsa-miR-335-3p ZNF396 2.29463721765513 4.1956113745077e-18 -0.570174840955928 0.00394642916899578 mirMAP -0.196814637237819 3.44778814611327e-06 NA NA NA hsa-miR-141-5p ZNF407 2.13747696823946 1.73124674554872e-11 -0.0344063277091404 0.730273676730344 MirTarget -0.105519011189618 3.06516220587821e-09 NA NA NA hsa-miR-146b-5p ZNF418 2.23105707690238 3.83997814011313e-23 -0.966888901930751 0.000643682537459424 miRanda -0.29525538270855 2.89470554112637e-05 NA NA NA hsa-miR-200a-5p ZNF420 2.19152245759943 3.17968183522514e-11 -0.362128541140981 0.0466672408708079 MirTarget -0.123325617060732 0.000125459990630499 NA NA NA hsa-miR-200a-3p ZNF423 2.02394729844446 2.21240501925011e-08 -0.207391944090895 0.423116370581353 mirMAP -0.414167480253802 3.75172159142288e-27 NA NA NA hsa-miR-200b-3p ZNF423 2.06025765178663 3.07718049337497e-10 -0.207391944090895 0.423116370581353 MirTarget;TargetScan -0.441004141441394 2.76827175434507e-25 NA NA NA hsa-miR-200a-5p ZNF425 2.19152245759943 3.17968183522514e-11 -0.638550427402248 0.000171047747704608 mirMAP -0.234166229851387 5.28221416151688e-16 NA NA NA hsa-miR-335-3p ZNF439 2.29463721765513 4.1956113745077e-18 -0.619224720492104 0.00266821127783175 mirMAP -0.234480249135746 9.46027980515909e-08 NA NA NA hsa-miR-146b-5p ZNF441 2.23105707690238 3.83997814011313e-23 -0.135894327409074 0.318081793737102 miRanda -0.101512121199038 0.00263064848624234 NA NA NA hsa-miR-335-3p ZNF441 2.29463721765513 4.1956113745077e-18 -0.135894327409074 0.318081793737102 mirMAP -0.129779869895676 7.37663077139847e-06 NA NA NA hsa-miR-141-5p ZNF445 2.13747696823946 1.73124674554872e-11 0.353019491783618 0.00152699832029871 mirMAP -0.104566191673188 2.39599399203358e-07 NA NA NA hsa-miR-192-5p ZNF449 2.0867723747501 3.57854249239079e-08 0.27714056761396 0.0126076680026678 miRNAWalker2_validate -0.112718962180074 1.9531410783621e-11 NA NA NA hsa-miR-146b-5p ZNF467 2.23105707690238 3.83997814011313e-23 -0.771513991467088 3.40311341073714e-05 miRanda -0.204108746969945 1.13562855370267e-05 NA NA NA hsa-miR-200b-3p ZNF470 2.06025765178663 3.07718049337497e-10 -0.978816360280963 0.000167999655161037 mirMAP -0.299796614364302 6.05255394358104e-11 NA NA NA hsa-miR-335-3p ZNF470 2.29463721765513 4.1956113745077e-18 -0.978816360280963 0.000167999655161037 MirTarget -0.32502070955469 4.54075641121785e-09 NA NA NA hsa-miR-146b-5p ZNF471 2.23105707690238 3.83997814011313e-23 -1.56551559185972 3.66521900992363e-08 miRanda -0.47799510998692 9.69344753484265e-12 NA NA NA hsa-miR-200a-5p ZNF471 2.19152245759943 3.17968183522514e-11 -1.56551559185972 3.66521900992363e-08 mirMAP -0.52155697790137 4.5813082266027e-29 NA NA NA hsa-miR-335-3p ZNF501 2.29463721765513 4.1956113745077e-18 -0.0388022134459727 0.818067870083958 mirMAP -0.115760153559793 0.00139912931726138 NA NA NA hsa-miR-335-3p ZNF503 2.29463721765513 4.1956113745077e-18 -0.181694228720088 0.38691607250728 MirTarget -0.128900469878999 0.00440650076281581 NA NA NA hsa-miR-146b-5p ZNF512B 2.23105707690238 3.83997814011313e-23 -0.566120168951347 0.0123439167408622 MirTarget;miRanda;miRNATAP -0.24955507050497 8.16061430678807e-06 NA NA NA hsa-miR-200a-3p ZNF512B 2.02394729844446 2.21240501925011e-08 -0.566120168951347 0.0123439167408622 mirMAP -0.190319956575589 1.92865412889802e-07 NA NA NA hsa-miR-146b-3p ZNF516 2.08650140817622 5.3293570720033e-22 -0.530173332560438 0.00170477542591741 MirTarget;PITA;miRNATAP -0.16074926398014 0.000265535075353407 NA NA NA hsa-miR-194-5p ZNF516 2.24386881692218 9.35116329002209e-11 -0.530173332560438 0.00170477542591741 MirTarget;miRNATAP -0.196613595244404 1.27659704823507e-12 NA NA NA hsa-miR-200a-3p ZNF516 2.02394729844446 2.21240501925011e-08 -0.530173332560438 0.00170477542591741 miRNATAP -0.214912187573032 3.86239137133011e-16 NA NA NA hsa-miR-200b-3p ZNF516 2.06025765178663 3.07718049337497e-10 -0.530173332560438 0.00170477542591741 TargetScan;mirMAP -0.22395458531804 1.61525877688981e-14 NA NA NA hsa-miR-335-3p ZNF516 2.29463721765513 4.1956113745077e-18 -0.530173332560438 0.00170477542591741 mirMAP -0.125919677375916 0.000576848857155128 NA NA NA hsa-miR-935 ZNF516 2.321600496365 1.00042201726114e-07 -0.530173332560438 0.00170477542591741 PITA;miRNATAP -0.111208997179461 4.29108401992203e-06 NA NA NA hsa-miR-335-3p ZNF518B 2.29463721765513 4.1956113745077e-18 -0.810348186681662 0.0007591643900906 MirTarget -0.328623506341202 9.74077183297593e-11 NA NA NA hsa-miR-192-5p ZNF519 2.0867723747501 3.57854249239079e-08 0.233250382314415 0.142886283627222 miRNAWalker2_validate -0.128385798936462 1.50770128692082e-07 NA NA NA hsa-miR-194-5p ZNF532 2.24386881692218 9.35116329002209e-11 0.410685792071696 0.016269152211887 miRNATAP -0.242064658669683 5.41146439850446e-19 NA NA NA hsa-miR-200b-3p ZNF532 2.06025765178663 3.07718049337497e-10 0.410685792071696 0.016269152211887 MirTarget;TargetScan -0.242068622468561 9.30894745115562e-17 NA NA NA hsa-miR-192-5p ZNF536 2.0867723747501 3.57854249239079e-08 -3.1152711669602 5.90737676762807e-13 MirTarget;miRNATAP -0.357154181776337 3.1335392215993e-07 NA NA NA hsa-miR-335-3p ZNF546 2.29463721765513 4.1956113745077e-18 -0.274086972889827 0.0963608127098635 mirMAP -0.204443702333338 3.76863057560321e-09 NA NA NA hsa-miR-194-5p ZNF548 2.24386881692218 9.35116329002209e-11 -0.0834198915887594 0.539456152328068 MirTarget -0.115463699860513 3.08379473609184e-07 NA NA NA hsa-miR-200a-3p ZNF555 2.02394729844446 2.21240501925011e-08 -0.287518617990034 0.0149526850886262 mirMAP -0.130853601360928 2.12433320011955e-12 NA NA NA hsa-miR-335-3p ZNF555 2.29463721765513 4.1956113745077e-18 -0.287518617990034 0.0149526850886262 mirMAP -0.105541759624366 2.98345731918897e-05 NA NA NA hsa-miR-335-3p ZNF559 2.29463721765513 4.1956113745077e-18 -0.387591208206637 0.0421037750846807 mirMAP -0.172811782989965 2.32825671801641e-05 NA NA NA hsa-miR-335-3p ZNF568 2.29463721765513 4.1956113745077e-18 -0.983580249411279 6.61260126560094e-06 MirTarget;mirMAP -0.355106818519808 7.33299034437939e-15 NA NA NA hsa-miR-335-3p ZNF569 2.29463721765513 4.1956113745077e-18 -0.831128254835905 0.000202547267802704 mirMAP -0.297102728920202 3.70925027899196e-10 NA NA NA hsa-miR-335-3p ZNF577 2.29463721765513 4.1956113745077e-18 -0.612334332403173 0.0121985857534022 mirMAP -0.190219233418377 0.000308323066850209 NA NA NA hsa-miR-335-3p ZNF583 2.29463721765513 4.1956113745077e-18 -0.849026146110339 3.5313563456954e-05 mirMAP -0.27044269839378 5.93887679394777e-10 NA NA NA hsa-miR-335-3p ZNF585A 2.29463721765513 4.1956113745077e-18 -0.459382115645294 0.00154966773151106 MirTarget -0.10459415418343 0.000871012637451498 NA NA NA hsa-miR-335-3p ZNF585B 2.29463721765513 4.1956113745077e-18 -0.319178497896519 0.0929207216304222 mirMAP -0.119241397667266 0.00363556096617847 NA NA NA hsa-miR-183-5p ZNF605 2.08412478942637 1.08931431254487e-10 -0.0490092584052366 0.821846663176975 MirTarget -0.137594699990687 0.000474926960211886 NA NA NA hsa-miR-200b-3p ZNF605 2.06025765178663 3.07718049337497e-10 -0.0490092584052366 0.821846663176975 MirTarget -0.106818590547472 0.00628502079115436 NA NA NA hsa-miR-200a-3p ZNF606 2.02394729844446 2.21240501925011e-08 -0.475818114253522 0.068065199781927 MirTarget -0.185548603886379 1.1782471648367e-05 NA NA NA hsa-miR-146b-5p ZNF608 2.23105707690238 3.83997814011313e-23 -0.147277813082137 0.475784033752482 miRanda -0.107532445869353 0.0368949042550769 NA NA NA hsa-miR-335-3p ZNF614 2.29463721765513 4.1956113745077e-18 -0.337169637106784 0.0738796243909195 mirMAP -0.110125208796736 0.00691654816699479 NA NA NA hsa-miR-194-5p ZNF615 2.24386881692218 9.35116329002209e-11 -0.533248246799516 0.00435397052936993 MirTarget -0.196865964426039 1.8859268673054e-10 NA NA NA hsa-miR-335-3p ZNF615 2.29463721765513 4.1956113745077e-18 -0.533248246799516 0.00435397052936993 mirMAP -0.194991610878652 1.07899100881415e-06 NA NA NA hsa-miR-146b-5p ZNF626 2.23105707690238 3.83997814011313e-23 -1.5464185643606 3.88442816696789e-09 miRanda -0.28344895285082 2.2147311007454e-05 NA NA NA hsa-miR-192-5p ZNF641 2.0867723747501 3.57854249239079e-08 -0.017286068034279 0.852780011752403 miRNAWalker2_validate -0.106043730781173 1.46076571738426e-14 NA NA NA hsa-miR-146b-5p ZNF649 2.23105707690238 3.83997814011313e-23 -0.808458032848121 0.000225343068154081 MirTarget;miRanda -0.234686389154049 1.7434985821468e-05 NA NA NA hsa-miR-135b-5p ZNF655 2.80066701698235 2.12546333413447e-11 -0.826756558653837 5.25368973610172e-05 MirTarget -0.13587762035764 6.03988014644356e-06 NA NA NA hsa-miR-192-5p ZNF655 2.0867723747501 3.57854249239079e-08 -0.826756558653837 5.25368973610172e-05 mirMAP -0.166798208007879 1.64223004485991e-07 NA NA NA hsa-miR-196a-5p ZNF655 5.05945965885472 4.48343841468539e-25 -0.826756558653837 5.25368973610172e-05 miRNATAP -0.145131708289286 3.53612750239556e-10 NA NA NA hsa-miR-196b-5p ZNF655 4.51951031652328 7.04026169031626e-18 -0.826756558653837 5.25368973610172e-05 miRNATAP -0.146857641645457 1.29554401145198e-11 NA NA NA hsa-miR-200b-3p ZNF655 2.06025765178663 3.07718049337497e-10 -0.826756558653837 5.25368973610172e-05 MirTarget -0.16282992286318 9.96921898171846e-06 NA NA NA hsa-miR-335-3p ZNF655 2.29463721765513 4.1956113745077e-18 -0.826756558653837 5.25368973610172e-05 mirMAP -0.2083263839905 2.3432383858521e-06 NA NA NA hsa-miR-146b-5p ZNF662 2.23105707690238 3.83997814011313e-23 -1.88043061006014 2.81229008426511e-10 miRanda -0.531450085250842 6.22988298528406e-13 NA NA NA hsa-miR-183-5p ZNF662 2.08412478942637 1.08931431254487e-10 -1.88043061006014 2.81229008426511e-10 MirTarget -0.518621544938166 9.44556710648211e-24 NA NA NA hsa-miR-200b-3p ZNF662 2.06025765178663 3.07718049337497e-10 -1.88043061006014 2.81229008426511e-10 TargetScan -0.464721724566856 3.94538746603031e-19 NA NA NA hsa-miR-335-3p ZNF662 2.29463721765513 4.1956113745077e-18 -1.88043061006014 2.81229008426511e-10 mirMAP -0.484394123093898 2.78366783799611e-14 NA NA NA hsa-miR-21-5p ZNF667 2.21515015440792 6.0468197386674e-49 -0.765209789722188 0.00575237963736784 miRNAWalker2_validate -0.44394090488413 1.92969073762543e-06 NA NA NA hsa-miR-146b-5p ZNF676 2.23105707690238 3.83997814011313e-23 -1.38855613204069 0.00110722160966977 MirTarget;miRanda -0.500672699565247 2.09598236375301e-06 NA NA NA hsa-miR-200a-5p ZNF677 2.19152245759943 3.17968183522514e-11 -1.19588042263771 1.66267978030496e-06 mirMAP -0.447274187083564 6.1008385494663e-28 NA NA NA hsa-miR-335-3p ZNF682 2.29463721765513 4.1956113745077e-18 -0.565031684660943 0.0322693695271567 MirTarget;mirMAP -0.227698982781729 5.91855892446956e-05 NA NA NA hsa-miR-146b-5p ZNF704 2.23105707690238 3.83997814011313e-23 -0.446994599853389 0.116513806383905 mirMAP -0.419537460636231 1.26314958103062e-09 NA NA NA hsa-miR-18a-5p ZNF704 2.04701000113742 1.30593450319289e-12 -0.446994599853389 0.116513806383905 miRNATAP -0.234151601304322 4.21741941176453e-05 NA NA NA hsa-miR-192-5p ZNF704 2.0867723747501 3.57854249239079e-08 -0.446994599853389 0.116513806383905 miRNAWalker2_validate -0.159073483939168 0.000344526735688431 NA NA NA hsa-miR-200b-3p ZNF704 2.06025765178663 3.07718049337497e-10 -0.446994599853389 0.116513806383905 mirMAP -0.270214316951829 7.66283542017419e-08 NA NA NA hsa-miR-21-5p ZNF704 2.21515015440792 6.0468197386674e-49 -0.446994599853389 0.116513806383905 MirTarget;miRNATAP -0.402916081649815 2.61621518491686e-05 NA NA NA hsa-miR-935 ZNF704 2.321600496365 1.00042201726114e-07 -0.446994599853389 0.116513806383905 miRNATAP -0.209801627330846 1.96777469609345e-07 NA NA NA hsa-miR-146b-5p ZNF76 2.23105707690238 3.83997814011313e-23 -0.181411637713397 0.0344626465238934 miRanda -0.103136970969724 8.15342508224198e-07 NA NA NA hsa-miR-200b-3p ZNF772 2.06025765178663 3.07718049337497e-10 -0.0126936459846325 0.959345668610764 mirMAP -0.145835009509718 0.00107667837170411 NA NA NA hsa-miR-335-3p ZNF781 2.29463721765513 4.1956113745077e-18 -0.979768661668805 7.31124993771246e-05 mirMAP -0.392868565078888 2.59778102987739e-14 NA NA NA hsa-miR-146b-5p ZNF788 2.23105707690238 3.83997814011313e-23 -0.487925876294344 0.0251611888929929 miRanda -0.164818062652624 0.00243038931117136 NA NA NA hsa-miR-200a-5p ZNF788 2.19152245759943 3.17968183522514e-11 -0.487925876294344 0.0251611888929929 mirMAP -0.258536445675054 4.66656168602888e-12 NA NA NA hsa-miR-335-3p ZNF788 2.29463721765513 4.1956113745077e-18 -0.487925876294344 0.0251611888929929 mirMAP -0.264813646172226 9.10072374594867e-09 NA NA NA hsa-miR-146b-5p ZNF793 2.23105707690238 3.83997814011313e-23 -1.09057837455347 0.000314123281952348 mirMAP -0.212402480178439 0.00532629229435843 NA NA NA hsa-miR-335-3p ZNF793 2.29463721765513 4.1956113745077e-18 -1.09057837455347 0.000314123281952348 MirTarget;mirMAP -0.305737806147912 2.73694539970169e-06 NA NA NA hsa-miR-146b-5p ZNF813 2.23105707690238 3.83997814011313e-23 -0.334476120598831 0.257857818627765 MirTarget;PITA;miRanda -0.169709629416303 0.0214767656595796 NA NA NA hsa-miR-146b-5p ZNF829 2.23105707690238 3.83997814011313e-23 -0.806605652699805 0.000605618293534488 miRanda -0.264418036985298 6.04463486066772e-06 NA NA NA hsa-miR-335-3p ZNF831 2.29463721765513 4.1956113745077e-18 -0.099709967336861 0.754521870559919 mirMAP -0.190500083221121 0.00561784061724914 NA NA NA hsa-miR-335-3p ZNF846 2.29463721765513 4.1956113745077e-18 -0.282934329529065 0.0588475198033481 mirMAP -0.137221690833853 1.80723590519764e-05 NA NA NA hsa-miR-192-5p ZNF85 2.0867723747501 3.57854249239079e-08 -0.290701683812118 0.152906418227546 miRNAWalker2_validate -0.109360241200319 0.000567121526582895 NA NA NA hsa-miR-200a-5p ZNF85 2.19152245759943 3.17968183522514e-11 -0.290701683812118 0.152906418227546 MirTarget -0.116684700538115 0.00119767058120546 NA NA NA hsa-miR-192-5p ZNF862 2.0867723747501 3.57854249239079e-08 -0.0578004760981914 0.691775946018786 mirMAP -0.119312781957441 8.9289959570009e-08 NA NA NA hsa-miR-146b-5p ZNF880 2.23105707690238 3.83997814011313e-23 -0.986350932570258 0.000330834791337815 miRanda -0.271560173810631 7.66024375411508e-05 NA NA NA hsa-miR-21-5p ZRANB1 2.21515015440792 6.0468197386674e-49 -0.162987253940597 0.104519813914062 miRNAWalker2_validate -0.147657764003379 1.06163251655857e-05 NA NA NA hsa-miR-146b-5p ZSCAN23 2.23105707690238 3.83997814011313e-23 -1.23565708693229 0.000372885460366937 miRanda -0.382918268978222 9.48853449879725e-06 NA NA NA hsa-miR-200a-3p ZSCAN23 2.02394729844446 2.21240501925011e-08 -1.23565708693229 0.000372885460366937 miRNATAP -0.466866506925644 5.90796646165837e-18 NA NA NA hsa-miR-335-3p ZSCAN23 2.29463721765513 4.1956113745077e-18 -1.23565708693229 0.000372885460366937 mirMAP -0.481698759127611 5.05650652541687e-11 NA NA NA hsa-miR-146b-3p ZSWIM5 2.08650140817622 5.3293570720033e-22 -0.0717689222513047 0.77945142590442 PITA;miRNATAP -0.243923076771669 0.000234890399143015 NA NA NA hsa-miR-146b-5p ZSWIM5 2.23105707690238 3.83997814011313e-23 -0.0717689222513047 0.77945142590442 miRanda -0.240870917395814 0.000143137197571549 NA NA NA hsa-miR-18a-5p ZSWIM6 2.04701000113742 1.30593450319289e-12 -0.433553897728624 1.52139610356126e-05 miRNAWalker2_validate -0.108153680512356 7.16900181044978e-08 NA NA NA hsa-miR-21-5p ZSWIM6 2.21515015440792 6.0468197386674e-49 -0.433553897728624 1.52139610356126e-05 MirTarget;miRNATAP -0.143528966566442 2.47539359339102e-05 NA NA NA hsa-miR-200a-3p ZYG11B 2.02394729844446 2.21240501925011e-08 -0.120538055007567 0.278257919741293 MirTarget -0.148619086479882 2.37513447924138e-18 NA NA NA hsa-miR-200a-5p ZYG11B 2.19152245759943 3.17968183522514e-11 -0.120538055007567 0.278257919741293 mirMAP -0.167730668770447 5.0989971296313e-20 NA NA NA hsa-miR-200b-3p ZYG11B 2.06025765178663 3.07718049337497e-10 -0.120538055007567 0.278257919741293 TargetScan -0.154191951640231 2.6373221635263e-16 NA NA NA hsa-miR-21-5p ZYG11B 2.21515015440792 6.0468197386674e-49 -0.120538055007567 0.278257919741293 miRNAWalker2_validate;mirMAP -0.11454476109684 0.00223807809844976 NA NA NA hsa-miR-335-3p ZYG11B 2.29463721765513 4.1956113745077e-18 -0.120538055007567 0.278257919741293 mirMAP -0.111787136254917 2.07065353736259e-06 NA NA NA