miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-224-5p AFF3 2.65799597897592 2.73629620293273e-08 -4.00469653102997 7.69598041725563e-12 MirTarget -0.489480339393867 2.56887683469959e-41 NA NA NA hsa-miR-452-5p BCAS1 2.0200941872388 0.000263136484394316 -4.84639733592195 2.71035483325212e-26 mirMAP -0.653153229792534 1.33230017711067e-41 NA NA NA hsa-miR-18a-5p CA12 2.29585803678176 4.13931899001596e-14 -4.60824015441829 2.67223288642364e-10 miRNAWalker2_validate;MirTarget -0.845217777323844 1.2280252750954e-70 NA NA NA hsa-miR-18a-5p CACNG4 2.29585803678176 4.13931899001596e-14 -3.35808733108355 1.01411652848366e-09 mirMAP -0.479660977852052 1.65065818706956e-15 NA NA NA hsa-miR-224-5p CADM2 2.65799597897592 2.73629620293273e-08 -2.36354384514459 1.18875938460695e-12 mirMAP -0.163386837056061 1.0673293905645e-05 NA NA NA hsa-miR-452-5p CADM2 2.0200941872388 0.000263136484394316 -2.36354384514459 1.18875938460695e-12 MirTarget -0.127988416533862 0.00422312676275801 NA NA NA hsa-miR-452-5p CASC1 2.0200941872388 0.000263136484394316 -2.5594283466148 1.38668898218657e-27 MirTarget -0.445159797294547 6.93699779838269e-47 NA NA NA hsa-miR-452-5p CST5 2.0200941872388 0.000263136484394316 -3.37394967327104 2.03483092750856e-08 MirTarget -0.752071633068046 1.05784681317653e-30 NA NA NA hsa-miR-18a-5p CYP4F11 2.29585803678176 4.13931899001596e-14 -2.83072267551312 1.17177976552715e-13 MirTarget -0.608616466590783 3.56154348444121e-22 NA NA NA hsa-miR-452-5p DACH1 2.0200941872388 0.000263136484394316 -4.04866918627824 9.79741263930395e-20 mirMAP -0.511118870941053 3.69161116107759e-34 NA NA NA hsa-miR-224-5p DIO1 2.65799597897592 2.73629620293273e-08 -3.83209753849657 3.31056225830015e-21 miRTarBase -0.352294553302583 1.05750240342598e-13 NA NA NA hsa-miR-452-5p ERBB4 2.0200941872388 0.000263136484394316 -5.37185314288958 2.30708721608433e-25 mirMAP -0.701884213446386 2.37990608843616e-40 NA NA NA hsa-miR-18a-5p ESR1 2.29585803678176 4.13931899001596e-14 -6.14976130956365 3.35739499466122e-17 miRNAWalker2_validate;miRTarBase;miRNATAP -1.14044745041939 3.5647791599912e-74 19027010;24975878 MicroRNA 18a prevents estrogen receptor alpha expression promoting proliferation of hepatocellular carcinoma cells; The gene ESR1 which encodes the estrogen receptor-alpha ERalpha was identified as a target of miR-18a miR-18a can repress ERalpha translation by binding to its mRNA at the 3' untranslated region;Elevated p53 promotes the processing of miR 18a to decrease estrogen receptor α in female hepatocellular carcinoma; Our previous study identified that estrogen receptor alpha ERα protein is downregulated in 60% of female HCC cases via a miR-18a elevation mediated suppression of ERα translation ; liver cancer;liver cancer hsa-miR-224-5p FAM135B 2.65799597897592 2.73629620293273e-08 -2.43135181508455 2.06009646343704e-11 MirTarget -0.30557314375627 1.42552693168215e-16 NA NA NA hsa-miR-18a-5p FAM196A 2.29585803678176 4.13931899001596e-14 -2.85680700789912 4.07793226917642e-15 MirTarget -0.558344683915752 1.52927869844399e-19 NA NA NA hsa-miR-452-5p FAM196A 2.0200941872388 0.000263136484394316 -2.85680700789912 4.07793226917642e-15 mirMAP -0.61021539959501 6.07189040503729e-36 NA NA NA hsa-miR-18a-5p FBP1 2.29585803678176 4.13931899001596e-14 -2.60007311712345 3.66468362738828e-06 MirTarget -0.497445174576123 3.83311300421063e-49 NA NA NA hsa-miR-452-5p GFRA1 2.0200941872388 0.000263136484394316 -4.85069320193536 6.52030013074464e-12 MirTarget -0.599828090586184 6.96296920386979e-25 NA NA NA hsa-miR-224-5p HS6ST3 2.65799597897592 2.73629620293273e-08 -3.19061435708173 6.63410358317936e-16 MirTarget -0.331132200847354 2.79506841971763e-13 NA NA NA hsa-miR-452-5p IL6ST 2.0200941872388 0.000263136484394316 -2.17150435425912 0.000169593545858536 mirMAP -0.219664066998091 1.43869954863149e-07 NA NA NA hsa-miR-452-5p INPP4B 2.0200941872388 0.000263136484394316 -2.68378356215407 1.84906706606539e-10 mirMAP -0.285594648215494 5.57157212691772e-23 NA NA NA hsa-miR-224-5p KCNE4 2.65799597897592 2.73629620293273e-08 -2.6152814086228 9.02454775558146e-08 mirMAP -0.302286449119529 8.53597694360533e-22 NA NA NA hsa-miR-224-5p KCNH1 2.65799597897592 2.73629620293273e-08 -3.12169397110623 1.56314813864157e-25 MirTarget -0.375868106199318 7.1188709842689e-28 NA NA NA hsa-miR-224-5p KLHDC7A 2.65799597897592 2.73629620293273e-08 -4.3487862729619 9.42670341462602e-21 mirMAP -0.397808497383201 8.83498153367304e-16 NA NA NA hsa-miR-452-5p LIN7A 2.0200941872388 0.000263136484394316 -2.45859632114862 2.74066706763849e-16 mirMAP -0.111961366269578 0.00702279037426733 NA NA NA hsa-miR-18a-5p LONRF2 2.29585803678176 4.13931899001596e-14 -3.45738858653069 1.11871959084766e-13 mirMAP -0.656490113300794 9.01275306546033e-40 NA NA NA hsa-miR-224-5p LONRF2 2.65799597897592 2.73629620293273e-08 -3.45738858653069 1.11871959084766e-13 mirMAP -0.416771985708289 2.44492523233115e-35 NA NA NA hsa-miR-452-5p LYPD6 2.0200941872388 0.000263136484394316 -2.21413531746783 1.42051968104332e-08 MirTarget -0.348098315464678 9.21763428330733e-19 NA NA NA hsa-miR-452-5p NCAM2 2.0200941872388 0.000263136484394316 -3.27738197515256 1.98213311238206e-21 mirMAP -0.356299124015064 3.73144417802513e-19 NA NA NA hsa-miR-452-5p NOSTRIN 2.0200941872388 0.000263136484394316 -2.59510417514666 4.12335730393631e-09 miRNATAP -0.173686899148375 1.96996161118543e-08 NA NA NA hsa-miR-452-5p PAX9 2.0200941872388 0.000263136484394316 -2.24734881804845 9.61750952378173e-13 mirMAP -0.252211785432396 5.48995649421011e-12 NA NA NA hsa-miR-452-5p PGR 2.0200941872388 0.000263136484394316 -4.97051494401714 4.92890957537725e-17 mirMAP -0.57638681638652 2.82946527475521e-23 NA NA NA hsa-miR-18a-5p RIMS4 2.29585803678176 4.13931899001596e-14 -3.89846167236698 2.86202829464093e-19 mirMAP -0.416951868244038 5.72613913864664e-11 NA NA NA hsa-miR-18a-5p ROBO2 2.29585803678176 4.13931899001596e-14 -3.25296458550521 1.00896676774904e-16 miRNATAP -0.507935667314834 4.30543821372391e-14 NA NA NA hsa-miR-224-5p SHISA9 2.65799597897592 2.73629620293273e-08 -2.22621195772902 1.00297389872667e-08 MirTarget -0.156485774336624 0.000347300328186189 NA NA NA hsa-miR-452-5p SHISA9 2.0200941872388 0.000263136484394316 -2.22621195772902 1.00297389872667e-08 mirMAP -0.174415216371001 0.000911859347080672 NA NA NA hsa-miR-452-5p SYT1 2.0200941872388 0.000263136484394316 -2.82001079104867 1.28047553625102e-11 mirMAP;miRNATAP -0.418845673195687 4.16129562687673e-18 NA NA NA hsa-miR-452-5p TMEM232 2.0200941872388 0.000263136484394316 -2.42126759270621 8.37783244298747e-21 MirTarget -0.221650669813412 7.60839038461403e-11 NA NA NA hsa-miR-452-5p UBXN10 2.0200941872388 0.000263136484394316 -3.09210197444433 7.28012249492845e-17 mirMAP -0.385881289717446 1.49659221274655e-32 NA NA NA hsa-miR-18a-5p ZNF703 2.29585803678176 4.13931899001596e-14 -2.50586372969953 1.76003330852868e-07 miRNAWalker2_validate -0.407959604276437 3.01410946735778e-28 NA NA NA