miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-140-3p ABL1 -0.123864258867705 0.14796686619449 0.0143957445246503 0.802818620463351 MirTarget;PITA -0.108292549966284 4.03747363160958e-05 NA NA NA hsa-miR-149-5p ABL1 -0.0535821592029952 0.657713892012548 0.0143957445246503 0.802818620463351 miRNAWalker2_validate -0.149998583909469 8.50330650278858e-28 NA NA NA hsa-miR-29a-3p ABL1 -0.224140851576083 0.0349516103550236 0.0143957445246503 0.802818620463351 miRNAWalker2_validate;miRNATAP -0.129389826504859 4.38987333540906e-10 NA NA NA hsa-miR-29a-5p ABL1 -0.0697727833812678 0.350621682973119 0.0143957445246503 0.802818620463351 MirTarget -0.110556620114591 1.96554256170541e-06 NA NA NA hsa-miR-29b-3p ABL1 -0.178522712044497 0.0856106432165465 0.0143957445246503 0.802818620463351 miRNATAP -0.183750024397894 1.77278201614351e-25 NA NA NA hsa-miR-29c-3p ABL1 -0.372180390387259 0.00202634431973208 0.0143957445246503 0.802818620463351 miRNATAP -0.147792143048995 5.28105050732972e-23 NA NA NA hsa-miR-30a-5p ABL1 -0.062942936611238 0.513851954700252 0.0143957445246503 0.802818620463351 miRNAWalker2_validate;MirTarget;miRNATAP -0.235909063634104 1.3973277936456e-16 23287430 In K562 leukemia cells overexpression of miR-30a reduced ABL1 and BCR-ABL1 protein expression decreased proliferation and arrested cell cycle progression between G1 and S; These findings strongly suggest that miR-30a acts as a tumor suppressor by downregulating ABL1 and BCR-ABL1 expression progression chronic myeloid leukemia hsa-miR-30b-5p ABL1 -0.0858101016322106 0.263243418521854 0.0143957445246503 0.802818620463351 MirTarget;miRNATAP -0.120907821952767 6.32750624886575e-06 NA NA NA hsa-miR-30c-5p ABL1 -0.0469114469943097 0.565934557464627 0.0143957445246503 0.802818620463351 MirTarget;miRNATAP -0.149123058508228 2.48075647790404e-08 NA NA NA hsa-miR-30d-5p ABL1 -0.0607010868720046 0.471410043548794 0.0143957445246503 0.802818620463351 MirTarget;miRNATAP -0.139463869338977 5.35496466278748e-06 NA NA NA hsa-miR-3127-5p ABL1 -0.0645479321229978 0.382330591204685 0.0143957445246503 0.802818620463351 MirTarget -0.107898733709439 3.77555360940339e-06 NA NA NA hsa-miR-342-3p ABL1 -0.125683829770877 0.105810751640137 0.0143957445246503 0.802818620463351 miRNAWalker2_validate -0.128206724043204 1.6799883909592e-07 NA NA NA hsa-miR-361-5p ABL1 0.0107519600643302 0.882230614095565 0.0143957445246503 0.802818620463351 miRanda -0.174366067528748 1.67168382685165e-09 NA NA NA hsa-miR-484 ABL1 -0.0190828819137732 0.802298900989652 0.0143957445246503 0.802818620463351 miRNAWalker2_validate -0.162527559241345 6.87631889536367e-12 NA NA NA hsa-miR-488-3p ABL1 -0.257955761012568 0.00280795162806256 0.0143957445246503 0.802818620463351 mirMAP -0.107458785475156 8.58266909621695e-08 NA NA NA hsa-let-7d-5p ABL2 0.111345229817909 0.0872634398336815 -0.1214081782743 0.0131084313787595 miRNATAP -0.181358528475971 2.70532810683099e-09 NA NA NA hsa-let-7e-5p ABL2 0.0471189209570344 0.657255455444655 -0.1214081782743 0.0131084313787595 miRNATAP -0.14106504077808 7.36531761674068e-16 NA NA NA hsa-let-7g-5p ABL2 -0.0253396334608382 0.742556489443668 -0.1214081782743 0.0131084313787595 miRNATAP -0.132868929543093 1.13617746459423e-06 NA NA NA hsa-let-7i-5p ABL2 0.0952853587923244 0.192120688957249 -0.1214081782743 0.0131084313787595 miRNATAP -0.15311183598437 4.36831384094223e-08 NA NA NA hsa-miR-103a-3p ABL2 -0.147443193527362 0.128400914654149 -0.1214081782743 0.0131084313787595 miRNAWalker2_validate;MirTarget;miRNATAP -0.222280794676588 2.32508166807323e-16 NA NA NA hsa-miR-106a-5p ABL2 0.110074064773897 0.13045815990621 -0.1214081782743 0.0131084313787595 MirTarget -0.109128628274662 3.22733707782529e-06 NA NA NA hsa-miR-1226-3p ABL2 -0.098618802853881 0.346683714981524 -0.1214081782743 0.0131084313787595 MirTarget -0.105435248753782 4.26139980445305e-12 NA NA NA hsa-miR-125a-5p ABL2 -0.0833349424517387 0.325440200253607 -0.1214081782743 0.0131084313787595 MirTarget;PITA -0.207520345831679 7.87866195685265e-20 26766902 MicroRNA 125a 5p modulates human cervical carcinoma proliferation and migration by targeting ABL2; The direct regulation of miR-125a-5p on its target gene ABL proto-oncogene 2 ABL2 in cervical carcinoma was evaluated by quantitative real-time reverse transcription polymerase chain reaction Western blotting and luciferase reporter assays respectively; ABL2 was shown to be directly targeted by miR-125a-5p; In cervical carcinoma ABL2 gene and protein levels were both downregulated by miR-125a-5p cervical and endocervical cancer hsa-miR-1266-5p ABL2 0.313515127917259 0.0138664194727392 -0.1214081782743 0.0131084313787595 MirTarget -0.132652053590132 7.69429477977579e-28 NA NA NA hsa-miR-141-3p ABL2 0.41120561991992 0.000393344390969055 -0.1214081782743 0.0131084313787595 MirTarget;TargetScan;miRNATAP -0.117418744325053 1.41958054696783e-17 NA NA NA hsa-miR-146b-5p ABL2 0.441078059667297 0.000237619929889385 -0.1214081782743 0.0131084313787595 MirTarget;PITA;mirMAP;miRNATAP -0.159197338498227 3.10452572072512e-33 NA NA NA hsa-miR-155-5p ABL2 0.969837380981085 5.86551495710056e-15 -0.1214081782743 0.0131084313787595 mirMAP -0.14543866155003 2.00896927888016e-34 NA NA NA hsa-miR-15a-5p ABL2 0.142658985373611 0.0536219185009004 -0.1214081782743 0.0131084313787595 MirTarget;miRNATAP -0.167045132716796 1.56591736126104e-10 NA NA NA hsa-miR-15b-5p ABL2 0.592863156692837 1.41971517354055e-10 -0.1214081782743 0.0131084313787595 MirTarget;miRNATAP -0.148957275568433 7.67155022014785e-17 NA NA NA hsa-miR-186-5p ABL2 0.0606381894130505 0.514217717592464 -0.1214081782743 0.0131084313787595 MirTarget;mirMAP -0.157576559552211 2.98574112382478e-17 NA NA NA hsa-miR-200b-3p ABL2 0.245768526504511 0.0580744465744737 -0.1214081782743 0.0131084313787595 MirTarget -0.130792819545647 2.79421156814245e-27 NA NA NA hsa-miR-200c-3p ABL2 0.413752622631695 8.6936333715621e-06 -0.1214081782743 0.0131084313787595 MirTarget -0.147889842892336 1.28992489920823e-18 NA NA NA hsa-miR-204-5p ABL2 -0.288588537398065 0.113371226435822 -0.1214081782743 0.0131084313787595 mirMAP -0.100582904588502 2.41050041678509e-33 NA NA NA hsa-miR-22-5p ABL2 0.0437233965539527 0.639996108995995 -0.1214081782743 0.0131084313787595 mirMAP -0.182727660200817 6.84376186887487e-28 NA NA NA hsa-miR-223-3p ABL2 -0.0272428307560952 0.814395950305568 -0.1214081782743 0.0131084313787595 mirMAP -0.109477719319011 7.16611446321275e-15 NA NA NA hsa-miR-2355-5p ABL2 0.00808596988211185 0.916165501155096 -0.1214081782743 0.0131084313787595 mirMAP -0.16068183747608 1.37823362049438e-13 NA NA NA hsa-miR-26a-2-3p ABL2 0.26597501648608 0.000796444054340143 -0.1214081782743 0.0131084313787595 MirTarget;mirMAP -0.133382996456969 3.07181160104713e-11 NA NA NA hsa-miR-26a-5p ABL2 0.033823776747294 0.726610414342369 -0.1214081782743 0.0131084313787595 MirTarget;miRNATAP -0.143077223734457 6.566760173575e-13 NA NA NA hsa-miR-26b-5p ABL2 -0.0984536538762768 0.231803769574623 -0.1214081782743 0.0131084313787595 MirTarget;miRNATAP -0.164254261548353 1.16041347263418e-12 NA NA NA hsa-miR-27a-3p ABL2 0.303760032895792 0.00457375391189806 -0.1214081782743 0.0131084313787595 MirTarget;miRNATAP -0.126531387951797 1.94233100357719e-15 NA NA NA hsa-miR-27b-3p ABL2 -0.0599187745243146 0.58208143475992 -0.1214081782743 0.0131084313787595 MirTarget;miRNATAP -0.118979803472455 1.42326499198776e-13 NA NA NA hsa-miR-29b-1-5p ABL2 0.191335428755774 0.00846436454790702 -0.1214081782743 0.0131084313787595 mirMAP -0.103166963727811 3.0993822957084e-06 NA NA NA hsa-miR-29b-2-5p ABL2 -0.26834261955727 0.00453760540520233 -0.1214081782743 0.0131084313787595 mirMAP -0.112219096616719 6.59310840017193e-11 NA NA NA hsa-miR-29b-3p ABL2 -0.178522712044497 0.0856106432165465 -0.1214081782743 0.0131084313787595 mirMAP -0.126285697212704 1.46552980939032e-13 NA NA NA hsa-miR-30a-3p ABL2 0.0655410309550977 0.509541256241954 -0.1214081782743 0.0131084313787595 mirMAP -0.15161862986906 3.19848948084682e-13 NA NA NA hsa-miR-30a-5p ABL2 -0.062942936611238 0.513851954700252 -0.1214081782743 0.0131084313787595 mirMAP;miRNATAP -0.274541322216427 4.05910881882796e-25 NA NA NA hsa-miR-30b-5p ABL2 -0.0858101016322106 0.263243418521854 -0.1214081782743 0.0131084313787595 mirMAP -0.153215931402321 1.08322393152782e-09 NA NA NA hsa-miR-30c-5p ABL2 -0.0469114469943097 0.565934557464627 -0.1214081782743 0.0131084313787595 mirMAP;miRNATAP -0.289998997639426 1.21123900498946e-33 NA NA NA hsa-miR-30d-3p ABL2 0.0854049347792898 0.20691254801121 -0.1214081782743 0.0131084313787595 mirMAP -0.120204632921787 5.32833553836993e-07 NA NA NA hsa-miR-30e-3p ABL2 0.00173769765874887 0.984965501547409 -0.1214081782743 0.0131084313787595 mirMAP -0.168397129290594 8.6662809191382e-13 NA NA NA hsa-miR-30e-5p ABL2 0.0764521828640934 0.41904991629622 -0.1214081782743 0.0131084313787595 mirMAP -0.166539870594884 1.99901680638961e-12 NA NA NA hsa-miR-361-5p ABL2 0.0107519600643302 0.882230614095565 -0.1214081782743 0.0131084313787595 mirMAP -0.200404335323046 1.51831332497681e-13 NA NA NA hsa-miR-365a-3p ABL2 -0.184222766207919 0.0292663235724171 -0.1214081782743 0.0131084313787595 mirMAP -0.167306072368154 1.4830062388395e-18 NA NA NA hsa-miR-500a-5p ABL2 0.0634452729978863 0.396072382601677 -0.1214081782743 0.0131084313787595 mirMAP -0.186926270618303 7.51748921598493e-19 NA NA NA hsa-miR-505-3p ABL2 0.115486008167472 0.109833720698312 -0.1214081782743 0.0131084313787595 miRNATAP -0.118683684279073 4.49078372473422e-07 NA NA NA hsa-miR-548b-3p ABL2 0.340474544210108 0.00224491592019745 -0.1214081782743 0.0131084313787595 miRNATAP -0.113977683499953 1.75085096005055e-15 NA NA NA hsa-miR-576-5p ABL2 0.106482276040047 0.194379152564166 -0.1214081782743 0.0131084313787595 mirMAP -0.149304462343574 2.21521972627812e-14 NA NA NA hsa-miR-589-5p ABL2 -0.0382528919634639 0.5844074434222 -0.1214081782743 0.0131084313787595 MirTarget;miRNATAP -0.153351081410021 8.71347902377263e-09 NA NA NA hsa-miR-590-3p ABL2 0.312951515438396 0.000480455423843996 -0.1214081782743 0.0131084313787595 PITA;mirMAP;miRNATAP -0.150712894482113 7.03542953304604e-18 NA NA NA hsa-miR-625-3p ABL2 -0.0638840950852737 0.547354471747105 -0.1214081782743 0.0131084313787595 mirMAP -0.117124316415271 1.96499333063309e-14 NA NA NA hsa-miR-93-5p ABL2 0.139766237971122 0.101057320076629 -0.1214081782743 0.0131084313787595 MirTarget -0.148309808815532 3.40820700654049e-07 NA NA NA hsa-miR-105-5p AKT2 -0.567459149851677 8.20858944634795e-06 0.139361896216647 0.0151763675439579 mirMAP -0.11517777162873 2.5456118337521e-14 NA NA NA hsa-miR-146b-5p AKT3 0.441078059667297 0.000237619929889385 -0.235109681312394 0.000861339724103604 miRNAWalker2_validate -0.14853390000962 1.54850741316524e-10 NA NA NA hsa-miR-15a-5p AKT3 0.142658985373611 0.0536219185009004 -0.235109681312394 0.000861339724103604 miRNAWalker2_validate;miRTarBase;miRNATAP -0.171093255137198 0.000104922528677221 NA NA NA hsa-miR-15b-5p AKT3 0.592863156692837 1.41971517354055e-10 -0.235109681312394 0.000861339724103604 miRNATAP -0.149023414077877 1.00397425898265e-06 NA NA NA hsa-miR-28-3p AKT3 0.139444423971018 0.0811187936164314 -0.235109681312394 0.000861339724103604 miRNATAP -0.281326919526608 6.94030005162363e-11 NA NA NA hsa-miR-320a AKT3 0.092135599636725 0.243028758989929 -0.235109681312394 0.000861339724103604 PITA;miRanda;miRNATAP -0.162091233103736 0.000150010109497495 NA NA NA hsa-miR-320c AKT3 0.343259124189966 0.000248338401291051 -0.235109681312394 0.000861339724103604 PITA;miRanda;miRNATAP -0.11345587888064 0.000121683825333423 NA NA NA hsa-miR-362-3p AKT3 0.032375035235532 0.736465332563774 -0.235109681312394 0.000861339724103604 miRanda -0.133145359057788 1.93504628679194e-06 NA NA NA hsa-miR-362-5p AKT3 -0.0730185557229279 0.425572997292224 -0.235109681312394 0.000861339724103604 PITA;TargetScan;miRNATAP -0.12269062278053 4.12753291036148e-05 NA NA NA hsa-miR-501-3p AKT3 0.0726267165568464 0.382729320534971 -0.235109681312394 0.000861339724103604 miRNATAP -0.230986821283872 3.52473505159126e-12 NA NA NA hsa-miR-502-3p AKT3 0.0276791089364088 0.697605011368848 -0.235109681312394 0.000861339724103604 miRNATAP -0.217874003496912 1.14360007951059e-08 NA NA NA hsa-miR-93-5p AKT3 0.139766237971122 0.101057320076629 -0.235109681312394 0.000861339724103604 miRNATAP -0.208262975522215 1.91431764461584e-05 NA NA NA hsa-miR-125a-5p ANGPT2 -0.0833349424517387 0.325440200253607 0.973073130335985 3.11405321255146e-13 miRanda -0.264795607577102 0.00227167877390085 NA NA NA hsa-miR-129-5p ANGPT2 -0.567133990117126 0.00116152215679936 0.973073130335985 3.11405321255146e-13 MirTarget;miRanda -0.318009570105921 2.19601545367872e-21 NA NA NA hsa-miR-135a-5p ANGPT2 -0.122734612943241 0.196985964641886 0.973073130335985 3.11405321255146e-13 MirTarget -0.302595816265356 2.66606536108577e-06 NA NA NA hsa-miR-138-5p ANGPT2 -0.616087649920851 1.35200027885729e-05 0.973073130335985 3.11405321255146e-13 MirTarget -0.292625041668636 1.45807993019987e-12 NA NA NA hsa-miR-299-5p ANGPT2 -0.0814737109317336 0.57620244226785 0.973073130335985 3.11405321255146e-13 miRNATAP -0.129772479402096 0.00169668460048174 NA NA NA hsa-miR-381-3p ANGPT2 -0.192118086401438 0.203198554750071 0.973073130335985 3.11405321255146e-13 mirMAP -0.136683239389105 0.000582223002645419 NA NA NA hsa-miR-491-3p ANGPT2 -0.523374665885358 1.93479565404951e-05 0.973073130335985 3.11405321255146e-13 MirTarget;miRNATAP -0.358806940804183 3.01453423361413e-14 NA NA NA hsa-miR-539-5p ANGPT2 -0.326485413953598 0.0554453076411246 0.973073130335985 3.11405321255146e-13 mirMAP -0.281490575938618 8.3747590779385e-17 NA NA NA hsa-miR-543 ANGPT2 -0.347737549779625 0.0157394585079683 0.973073130335985 3.11405321255146e-13 MirTarget;PITA;miRanda;miRNATAP -0.240688906068078 8.16359448069276e-09 NA NA NA hsa-miR-582-5p ANGPT2 -0.215764335500665 0.0760892640434509 0.973073130335985 3.11405321255146e-13 mirMAP -0.229736619223816 1.95985705135758e-06 NA NA NA hsa-miR-744-3p ANGPT2 -0.226053568116656 0.0326553280112967 0.973073130335985 3.11405321255146e-13 MirTarget -0.268865282847753 2.38316775512343e-06 NA NA NA hsa-miR-9-5p ANGPT2 -0.125377971246422 0.269896477802284 0.973073130335985 3.11405321255146e-13 MirTarget -0.602205129123588 3.59342523707757e-06 NA NA NA hsa-miR-9-5p ARF6 -0.125377971246422 0.269896477802284 0.125538519018616 0.00370505862530834 MirTarget -0.195223291611649 3.30851816145505e-14 NA NA NA hsa-miR-3065-3p BDNF -0.261348288537884 0.0343753235107924 0.163817385359977 0.296772674802745 MirTarget;miRNATAP -0.263514713378115 5.47125066901657e-06 NA NA NA hsa-miR-3065-5p BDNF -0.262608140481507 0.0414570974148034 0.163817385359977 0.296772674802745 mirMAP;miRNATAP -0.276290459467715 1.96100180067284e-07 NA NA NA hsa-miR-30c-5p BRAP -0.0469114469943097 0.565934557464627 -0.0328779579087337 0.403424354509009 miRNATAP -0.165220607373566 3.15741787959275e-22 NA NA NA hsa-miR-30d-5p BRAP -0.0607010868720046 0.471410043548794 -0.0328779579087337 0.403424354509009 miRNATAP -0.104766122616975 1.72857120526914e-07 NA NA NA hsa-miR-195-3p CALM1 0.100105455903079 0.133362389112338 -0.280032159940063 0.00041663755448825 mirMAP -0.134166818079922 0.00105978192797807 NA NA NA hsa-miR-19a-3p CALM1 0.0466707843731911 0.576818938277755 -0.280032159940063 0.00041663755448825 miRNATAP -0.15911303134072 1.46727029621246e-06 NA NA NA hsa-miR-19b-3p CALM1 -0.0138427450847924 0.856506310673067 -0.280032159940063 0.00041663755448825 miRNATAP -0.185331239690791 2.55415494763863e-06 NA NA NA hsa-miR-423-5p CALM1 0.0965587900813789 0.148039180704338 -0.280032159940063 0.00041663755448825 miRNATAP -0.223655718300353 4.96731682524877e-07 NA NA NA hsa-miR-450b-5p CALM1 0.270544879013992 0.00801537838499562 -0.280032159940063 0.00041663755448825 PITA;miRNATAP -0.112486399533519 1.86205667354578e-05 NA NA NA hsa-miR-505-3p CALM1 0.115486008167472 0.109833720698312 -0.280032159940063 0.00041663755448825 mirMAP -0.104496375208374 0.00719334467208247 NA NA NA hsa-miR-195-3p CALM3 0.100105455903079 0.133362389112338 -0.293798285666567 0.00045242393570617 miRNATAP -0.12748406575783 0.00529207142199735 NA NA NA hsa-miR-320a CALM3 0.092135599636725 0.243028758989929 -0.293798285666567 0.00045242393570617 miRNAWalker2_validate;miRNATAP -0.196612953640571 2.55286701427654e-05 NA NA NA hsa-miR-320b CALM3 0.283477746304177 0.0005953763020907 -0.293798285666567 0.00045242393570617 miRNATAP -0.115852529351886 0.00116785195107089 NA NA NA hsa-miR-320c CALM3 0.343259124189966 0.000248338401291051 -0.293798285666567 0.00045242393570617 miRNATAP -0.155472573822685 1.34458221401277e-06 NA NA NA hsa-miR-374a-3p CALM3 0.176226170437625 0.0343958848425446 -0.293798285666567 0.00045242393570617 miRNATAP -0.174833175432543 7.53877059987187e-05 NA NA NA hsa-miR-3913-5p CALM3 0.276883251911602 0.00186113779811511 -0.293798285666567 0.00045242393570617 miRNATAP -0.13230009107403 6.45831616002777e-05 NA NA NA hsa-miR-15a-5p CHUK 0.142658985373611 0.0536219185009004 -0.0805827732736795 0.0444542176915521 miRNAWalker2_validate;miRTarBase;MirTarget -0.106856768478998 8.98534595935875e-07 NA NA NA hsa-miR-15b-5p CHUK 0.592863156692837 1.41971517354055e-10 -0.0805827732736795 0.0444542176915521 MirTarget -0.133202016968096 1.16700126521113e-19 NA NA NA hsa-miR-106a-5p CSF1 0.110074064773897 0.13045815990621 -0.122287343211195 0.20837887149901 miRNATAP -0.240789052612401 2.79463057370932e-05 NA NA NA hsa-miR-126-5p CSF1 0.177332403948664 0.0711675116243123 -0.122287343211195 0.20837887149901 MirTarget;miRNATAP -0.243683757786645 5.28079809914705e-09 NA NA NA hsa-miR-128-3p CSF1 -0.781932174412672 7.1812756321342e-10 -0.122287343211195 0.20837887149901 MirTarget -0.133621533589285 7.63301513989826e-05 22909061 By mutations in putative miRNA targets in CSF-1 mRNA 3'UTR we identified a common target for both miR-128 and miR-152; We have also found that both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro two major aspects of the metastatic potential of cancer cells; Our results provide the evidence for a mechanism by which miR-128 and miR-152 down-regulate CSF-1 an important regulator of ovarian cancer motility ovarian cancer hsa-miR-129-2-3p CSF1 -0.6175132197013 0.000561573620904867 -0.122287343211195 0.20837887149901 mirMAP -0.111728168442036 3.15538342899908e-07 NA NA NA hsa-miR-130b-3p CSF1 0.503911467685709 9.46590588950823e-08 -0.122287343211195 0.20837887149901 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.14220934501961 0.000833508067375941 22005523 CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system; CSF-1 expression was negatively associated with miR-130b level in ovarian tissues and cell lines; Luciferase assay validated CSF-1 is a direct target of miR-130b; Knock-down of CSF-1 sensitized ovarian cancer cells to anticancer drugs and could partially attenuate the resistance inducing effect of miR-130b inhibitors; Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1 and the silencing of miR-130b may be mediated by DNA methylation drug resistance ovarian cancer hsa-miR-143-5p CSF1 0.460068066898162 0.000603073392139956 -0.122287343211195 0.20837887149901 miRNATAP -0.115170590463889 7.88392671050427e-05 NA NA NA hsa-miR-149-5p CSF1 -0.0535821592029952 0.657713892012548 -0.122287343211195 0.20837887149901 MirTarget -0.10633586741869 0.00147513224183315 NA NA NA hsa-miR-15a-5p CSF1 0.142658985373611 0.0536219185009004 -0.122287343211195 0.20837887149901 miRNATAP -0.176070958656433 0.00667785808743751 NA NA NA hsa-miR-15b-5p CSF1 0.592863156692837 1.41971517354055e-10 -0.122287343211195 0.20837887149901 miRNATAP -0.131247161097271 0.00354209989429657 NA NA NA hsa-miR-16-5p CSF1 0.246024668671282 0.00346042804503716 -0.122287343211195 0.20837887149901 miRNATAP -0.240169370059159 1.44063203773933e-05 NA NA NA hsa-miR-20a-5p CSF1 -0.0115865752288853 0.887069448776018 -0.122287343211195 0.20837887149901 miRNATAP -0.179677651953267 0.00209303802178455 NA NA NA hsa-miR-20b-5p CSF1 0.144541062989476 0.0992042333556543 -0.122287343211195 0.20837887149901 miRNATAP -0.134233413074022 0.0059003006187718 NA NA NA hsa-miR-335-5p CSF1 0.0938511632756978 0.336889056387694 -0.122287343211195 0.20837887149901 miRNAWalker2_validate -0.132628847486485 0.00133179436677681 NA NA NA hsa-miR-30c-2-3p EFNA1 -0.18630560418806 0.0313113706136533 0.337108113379891 3.81958280466138e-06 MirTarget -0.126840381701099 0.00085468789803609 NA NA NA hsa-miR-9-5p EFNA1 -0.125377971246422 0.269896477802284 0.337108113379891 3.81958280466138e-06 miRNAWalker2_validate;miRNATAP -0.223689482833842 0.00073194365247171 NA NA NA hsa-miR-26b-5p EFNA2 -0.0984536538762768 0.231803769574623 0.134152515817659 0.264314464365408 miRNAWalker2_validate -0.396298086664645 1.86292354310792e-07 NA NA NA hsa-miR-342-5p EFNA2 0.0383784541944436 0.544128449296127 0.134152515817659 0.264314464365408 MirTarget -0.316596928413528 0.000205275737143976 NA NA NA hsa-miR-361-3p EFNA2 -0.0798653643614555 0.271064714084553 0.134152515817659 0.264314464365408 mirMAP -0.796067610747988 2.08219968447408e-23 NA NA NA hsa-miR-625-5p EFNA2 -0.0264137834407145 0.802098211251158 0.134152515817659 0.264314464365408 mirMAP -0.245664901798787 8.36860083834835e-07 NA NA NA hsa-miR-27a-3p EFNA3 0.303760032895792 0.00457375391189806 -0.326007302809337 0.000202745054179435 miRNATAP -0.163937979445285 1.02039144734868e-05 NA NA NA hsa-miR-30a-5p EFNA3 -0.062942936611238 0.513851954700252 -0.326007302809337 0.000202745054179435 MirTarget;mirMAP;miRNATAP -0.244879166747197 0.000108762712167237 NA NA NA hsa-miR-34c-5p EFNA3 0.181931113688093 0.257266965617363 -0.326007302809337 0.000202745054179435 miRanda -0.14878785349847 3.25939246145383e-11 NA NA NA hsa-let-7a-3p EFNA5 0.0530563276543763 0.370749834463566 -0.482975700052229 0.00104762446218271 miRNATAP -0.354026410437298 0.00394039235299539 NA NA NA hsa-miR-19a-3p EFNA5 0.0466707843731911 0.576818938277755 -0.482975700052229 0.00104762446218271 miRNATAP -0.247080133425123 0.00240023233655997 NA NA NA hsa-miR-19b-3p EFNA5 -0.0138427450847924 0.856506310673067 -0.482975700052229 0.00104762446218271 miRNATAP -0.266279550517469 0.00609487986507698 NA NA NA hsa-miR-20a-3p EFNA5 0.102743778777997 0.19677865359751 -0.482975700052229 0.00104762446218271 mirMAP -0.336591037233355 4.34602591593842e-05 NA NA NA hsa-miR-21-3p EFNA5 1.3484283943822 2.0036022227401e-17 -0.482975700052229 0.00104762446218271 mirMAP -0.179309789782236 7.63673417478275e-06 NA NA NA hsa-miR-450b-5p EFNA5 0.270544879013992 0.00801537838499562 -0.482975700052229 0.00104762446218271 mirMAP -0.182944381071667 0.00463791636947344 NA NA NA hsa-miR-767-5p EFNA5 -0.551653504513145 2.61109058244854e-05 -0.482975700052229 0.00104762446218271 miRNATAP -0.133236971379462 0.00794163349757635 NA NA NA hsa-miR-105-5p EGFR -0.567459149851677 8.20858944634795e-06 0.375473556369618 0.0155485714375729 mirMAP -0.353346118507539 9.24874721523108e-12 NA NA NA hsa-miR-133a-3p EGFR -0.335058908302964 0.0180402783121034 0.375473556369618 0.0155485714375729 miRNAWalker2_validate;miRTarBase;MirTarget -0.240130883772277 1.69412746009746e-07 26138587;26076812;25903369;26134491;24816813;22407299;27465833;23786162 Growth of glioblastoma is inhibited by miR 133 mediated EGFR suppression; Bioinformatic analysis was performed showing that miR-133 may target the 3'-untranslated region 3'-UTR of the epidermal growth factor receptor EGFR that transduces cell growth signals; Further the protein translation inhibition of EGFR by miR-133 was confirmed by a dual luciferase reporter assay; Together these data suggest that reduced miR-133 levels in GBM tissues promotes cell growth and decreases cell apoptosis possibly through targeting mRNA of EGFR to suppress its translation;Moreover the 3'-untranslated region 3'UTR of Her-2 the epidermal growth factor receptor EGFR that transduces cell growth signals appeared to be targeted by miR-133;MiR-133a expression was negatively correlated to lymphatic metastasis r = -0.182 P = 0.042 tumor size r = -0.253 P = 0.04 clinical TNM stages r = -0.154 P = 0.087 and EGFR protein expression r = -0.612 P < 0.001;miR 133a inhibits cervical cancer growth by targeting EGFR; The epidermal growth factor receptor EGFR was confirmed to be a direct target of miR-133a in cervical cancer cells using luciferase assay and western blotting; Restoration of miR-133a inhibited EGFR expression and activated the AKT and ERK signaling pathways; These results showed that miR-133a suppresses cervical cancer growth in vitro and in vivo through targeting EGFR suggesting that miR-133a can be a potential target for the treatment of cervical cancer;MiR-133a can inhibit cell invasiveness and cell growth through suppressing the expressions of IGF-1R TGFBR1 and EGFR which then influences the downstream signaling in lung cancer cell lines;We also provide the first evidence that miR-133 may target EGFR;Epidermal growth factor receptor EGFR expression and Akt phosphorylation were significantly suppressed after miR-133a transfection by western blot detection; miR-133a suppressed cell proliferation by suppressing the expression of EGFR and the phosphorylation of Akt;Bioinformatics prediction showed that epidermal growth factor receptor EGFR is a potential target for miR-133a; A dual luciferase reporter gene assay showed that miR-133a bound to the 3' UTR of EGFR but not a mutated 3' UTR thereby down-regulating the protein expression level; Accordingly we found that expression of EGFR protein decreased with increased expression of miR-133a in MCF-7 and MDA-MB-231 cells; These results demonstrate that miR-133a which may act as a tumor suppressor in breast cancer regulates the cell cycle and proliferation in tumorigenesis by targeting EGFR through the downstream signal molecule Akt ;;staging;metastasis;tumor size;;;;;tumorigenesis glioblastoma;gastric cancer;lung squamous cell cancer;cervical and endocervical cancer;lung squamous cell cancer;prostate cancer;breast cancer;breast cancer hsa-miR-134-5p EGFR 0.0228681180463912 0.875465441075562 0.375473556369618 0.0155485714375729 MirTarget -0.131424347245258 0.0046901253546818 24440911;27241841 We show that the RTKs MET EGFR and PDGFR regulate microRNA-134 miR-134 in GBM; We find that miR-134 is downregulated in human tumors and cancer stem cells and that its expression inversely correlates with the activation of MET EGFR and PDGFR;Luciferase assays confirmed that EGFR is a direct target of miR-134; Further mechanistic investigation including RNAi and rescue experiments suggested that the down-regulation of EGFR by miR-134 partially contributes to the antiproliferative role of miR-134; Taken together our findings suggest that miR-134 inhibits non-small cell lung cancer growth by targeting the EGFR ; glioblastoma;lung squamous cell cancer hsa-miR-140-5p EGFR 0.065063507103468 0.380452509211773 0.375473556369618 0.0155485714375729 miRanda -0.331443926880394 0.000604746363683769 NA NA NA hsa-miR-141-3p EGFR 0.41120561991992 0.000393344390969055 0.375473556369618 0.0155485714375729 MirTarget -0.272211860280112 2.20526685695345e-06 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-145-5p EGFR 0.108948399943015 0.310032352776693 0.375473556369618 0.0155485714375729 miRTarBase -0.222408723457338 0.000632008424910129 21653642;21289483;19493678 EGFR signals downregulate tumor suppressors miR 143 and miR 145 in Western diet promoted murine colon cancer: role of G1 regulators; Effects of EGFR on miR-143 and miR-145 expression were assessed in murine and human colonic cells and their putative targets examined in vitro and in vivo; EGFR signals suppressed miR-143 and miR-145 in human and murine colonic cells; EGFR suppresses miR-143 and miR-145 in murine models of colon cancer;MiR 145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1; We previously reported that restoration of hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor EGFR mutation; The mRNA expressions of EGFR and NUDT1 were significantly downregulated after miR-145 transfection in human lung adenocarcinoma cells; Our results demonstrated miR-145 in the negative regulation of EGFR and NUDT1 expressions at both mRNA and protein levels; Upregulation of miR-145 appeared to be an important gene regulation mechanism for the proliferation of lung adenocarcinoma cells and it correlated strongly with the downregulation of EGFR and NUDT1; Our findings provided new insight into the complex regulating pathway comprising of miR-145 EGFR NUDT1 and other unknown factors which function in cell proliferation but not in apoptosis;Our results also show that restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in EGFR mutant lung adenocarcinoma ;; colon cancer;lung cancer;lung cancer hsa-miR-146b-5p EGFR 0.441078059667297 0.000237619929889385 0.375473556369618 0.0155485714375729 miRNATAP -0.182905457755479 0.00149160880673993 NA NA NA hsa-miR-148b-5p EGFR 0.127111784487801 0.188731110216917 0.375473556369618 0.0155485714375729 mirMAP -0.239934018287681 0.000528231733121031 NA NA NA hsa-miR-17-5p EGFR 0.0975751369167082 0.20621110214601 0.375473556369618 0.0155485714375729 TargetScan -0.300424779505137 0.00473688540815432 NA NA NA hsa-miR-186-5p EGFR 0.0606381894130505 0.514217717592464 0.375473556369618 0.0155485714375729 mirMAP -0.362820595408749 3.23429208060765e-06 NA NA NA hsa-miR-199a-3p EGFR 0.41226331871076 0.000497136154474528 0.375473556369618 0.0155485714375729 mirMAP -0.155171655893965 0.00605438554579962 NA NA NA hsa-miR-199b-3p EGFR 0.411848361704393 0.000517815011892379 0.375473556369618 0.0155485714375729 mirMAP -0.153587230840804 0.00647308065495246 NA NA NA hsa-miR-27b-3p EGFR -0.0599187745243146 0.58208143475992 0.375473556369618 0.0155485714375729 MirTarget;miRNATAP -0.221076471767459 0.000976089469884623 NA NA NA hsa-miR-29b-2-5p EGFR -0.26834261955727 0.00453760540520233 0.375473556369618 0.0155485714375729 mirMAP -0.358417872879751 3.99667666062669e-07 NA NA NA hsa-miR-340-5p EGFR -0.110504550202736 0.20522426193476 0.375473556369618 0.0155485714375729 mirMAP -0.346218765115495 1.66785221313902e-05 NA NA NA hsa-miR-342-3p EGFR -0.125683829770877 0.105810751640137 0.375473556369618 0.0155485714375729 miRanda -0.663917527907302 1.30767225931049e-12 NA NA NA hsa-miR-362-5p EGFR -0.0730185557229279 0.425572997292224 0.375473556369618 0.0155485714375729 mirMAP -0.425583661873956 4.49473787679401e-09 NA NA NA hsa-miR-374a-3p EGFR 0.176226170437625 0.0343958848425446 0.375473556369618 0.0155485714375729 mirMAP -0.362986532828884 0.000239618326261467 NA NA NA hsa-miR-374b-3p EGFR 0.00769406264478478 0.897944859266164 0.375473556369618 0.0155485714375729 mirMAP -0.427233704833407 0.000162731500775749 NA NA NA hsa-miR-375 EGFR -0.0268401141324031 0.858358101444697 0.375473556369618 0.0155485714375729 miRanda -0.169128003930842 0.000103586363427282 NA NA NA hsa-miR-432-5p EGFR -0.214242438141977 0.166186087759946 0.375473556369618 0.0155485714375729 mirMAP -0.131937974290007 0.0019216701815729 NA NA NA hsa-miR-455-5p EGFR 0.332224239762 0.0106491358056238 0.375473556369618 0.0155485714375729 miRanda -0.204812179021233 5.18972286460639e-05 NA NA NA hsa-miR-490-3p EGFR -0.834268051506884 5.26203010743215e-06 0.375473556369618 0.0155485714375729 miRNATAP -0.120072101708822 0.00092511979931243 NA NA NA hsa-miR-491-5p EGFR -0.749881113074983 8.22859263179194e-09 0.375473556369618 0.0155485714375729 miRanda -0.15355901980036 0.00200795950337826 25299770 This latter effect is due to direct targeting of epidermal growth factor receptor EGFR by miR-491-5p and consequent inhibition of downstream AKT and MAPK signalling pathways; Induction of apoptosis by miR-491-5p in this cell line is mimicked by a combination of EGFR inhibition together with a BH3-mimetic molecule ovarian cancer hsa-miR-501-5p EGFR 0.0878951859817452 0.309663377222443 0.375473556369618 0.0155485714375729 mirMAP -0.204458704242994 0.00778191664099004 NA NA NA hsa-miR-539-5p EGFR -0.326485413953598 0.0554453076411246 0.375473556369618 0.0155485714375729 MirTarget;mirMAP -0.164306654210725 1.88169889749939e-05 NA NA NA hsa-miR-542-3p EGFR 0.0835995677900829 0.403838744494071 0.375473556369618 0.0155485714375729 miRanda -0.200337541146819 0.00617654519167961 NA NA NA hsa-miR-577 EGFR -0.382068371859275 0.0145513192729119 0.375473556369618 0.0155485714375729 mirMAP -0.117018511597701 0.00601694200161573 NA NA NA hsa-miR-590-3p EGFR 0.312951515438396 0.000480455423843996 0.375473556369618 0.0155485714375729 mirMAP -0.214045002105238 0.00365962356824128 NA NA NA hsa-miR-654-3p EGFR -0.00355488592826836 0.97967144096285 0.375473556369618 0.0155485714375729 mirMAP -0.128189186321505 0.00719754733314809 NA NA NA hsa-miR-7-1-3p EGFR -0.0894475316162393 0.37322359785108 0.375473556369618 0.0155485714375729 mirMAP -0.276379724120531 2.83072126766495e-05 NA NA NA hsa-miR-769-5p EGFR -0.320572895263071 0.00425481410304398 0.375473556369618 0.0155485714375729 mirMAP -0.16419521509748 0.00642768950459396 NA NA NA hsa-miR-877-5p EGFR -0.0775421790642756 0.423413623033696 0.375473556369618 0.0155485714375729 mirMAP -0.212946423195282 0.00180004411848772 NA NA NA hsa-miR-346 EPHA2 -0.577786425963268 2.10883270131593e-09 0.718117697865268 7.21288874557592e-12 miRanda -0.294975636384396 2.85375767140981e-10 NA NA NA hsa-miR-708-3p EPHA2 0.00458267260363954 0.962455132950708 0.718117697865268 7.21288874557592e-12 MirTarget -0.148182604049826 0.00520777648202178 NA NA NA hsa-miR-101-3p ETS1 -0.132333931567244 0.241891922291381 0.289405818491864 0.00108094176374498 miRNATAP -0.111671772665111 0.00739621111160386 NA NA NA hsa-miR-1180-3p ETS1 -0.241468809940139 0.0100726193195657 0.289405818491864 0.00108094176374498 MirTarget -0.343691017550362 5.96152219058525e-19 NA NA NA hsa-miR-125a-5p ETS1 -0.0833349424517387 0.325440200253607 0.289405818491864 0.00108094176374498 MirTarget;PITA -0.610243439726303 4.41450573576153e-35 NA NA NA hsa-miR-125b-2-3p ETS1 -0.0775572585326127 0.381771874712035 0.289405818491864 0.00108094176374498 mirMAP -0.255973270514044 6.47638392916985e-09 NA NA NA hsa-miR-125b-5p ETS1 -0.0119698382910496 0.890233923197358 0.289405818491864 0.00108094176374498 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.448537781195216 4.97421815304427e-13 21444677 miR 125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto oncogene in human invasive breast cancer; We identified the ETS1 gene as a novel direct target of miR-125b; siRNA-mediated ETS1 knockdown phenocopied the effect of miR-125b in breast cell lines and ETS1 overexpression in invasive breast cancer tissues also correlated with poor patient prognosis worse prognosis breast cancer hsa-miR-141-3p ETS1 0.41120561991992 0.000393344390969055 0.289405818491864 0.00108094176374498 mirMAP -0.157196943576216 6.1120687984464e-07 NA NA NA hsa-miR-148b-5p ETS1 0.127111784487801 0.188731110216917 0.289405818491864 0.00108094176374498 MirTarget -0.226383546441661 1.64949408978662e-09 NA NA NA hsa-miR-186-5p ETS1 0.0606381894130505 0.514217717592464 0.289405818491864 0.00108094176374498 mirMAP -0.392044169829488 2.95752975783617e-21 NA NA NA hsa-miR-193a-3p ETS1 0.395602305834739 0.00182611787714301 0.289405818491864 0.00108094176374498 miRanda;miRNATAP -0.1141219894259 8.5153405486353e-05 NA NA NA hsa-miR-200b-3p ETS1 0.245768526504511 0.0580744465744737 0.289405818491864 0.00108094176374498 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.249416414638896 1.24327138792733e-19 NA NA NA hsa-miR-200c-3p ETS1 0.413752622631695 8.6936333715621e-06 0.289405818491864 0.00108094176374498 MirTarget;miRNATAP -0.199351149923001 2.26840962502197e-07 NA NA NA hsa-miR-221-3p ETS1 -0.0109507285071775 0.936440693394519 0.289405818491864 0.00108094176374498 miRTarBase;miRNATAP -0.185904830604279 1.21242945142709e-12 21711453 To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions melanoma hsa-miR-222-3p ETS1 0.107117065575197 0.423818119725697 0.289405818491864 0.00108094176374498 miRNAWalker2_validate;miRTarBase;miRNATAP -0.178744853225697 1.51558521786963e-11 21711453 Constitutive activation of the ETS 1 miR 222 circuitry in metastatic melanoma; We demonstrate that the proto-oncogene ETS-1 involved in the pathogenesis of cancers of different origin is a transcriptional regulator of miR-222 by direct binding to its promoter region; Differently from 293FT cells or early stage melanomas where unphosphorylated ETS-1 represses miR-222 transcription in metastatic melanoma the constitutively Thr-38 phosphorylated fraction of ETS-1 induces miR-222; To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions staging melanoma hsa-miR-23a-3p ETS1 0.334693010651106 0.00144448147063433 0.289405818491864 0.00108094176374498 mirMAP -0.184730591138388 2.19931897327773e-06 NA NA NA hsa-miR-23b-3p ETS1 0.0476610245860094 0.630277683372344 0.289405818491864 0.00108094176374498 mirMAP -0.333640883900291 5.8253919475834e-17 NA NA NA hsa-miR-27b-5p ETS1 0.224282840351546 0.00630787296051719 0.289405818491864 0.00108094176374498 MirTarget;miRNATAP -0.368882536993378 8.80203243858556e-18 NA NA NA hsa-miR-29a-5p ETS1 -0.0697727833812678 0.350621682973119 0.289405818491864 0.00108094176374498 MirTarget;miRNATAP -0.339609289990795 2.88578918190408e-12 NA NA NA hsa-miR-3065-5p ETS1 -0.262608140481507 0.0414570974148034 0.289405818491864 0.00108094176374498 MirTarget;miRNATAP -0.234786448900039 9.88335269643552e-18 NA NA NA hsa-miR-30a-3p ETS1 0.0655410309550977 0.509541256241954 0.289405818491864 0.00108094176374498 mirMAP -0.29474461365939 3.29815322911299e-10 NA NA NA hsa-miR-30c-5p ETS1 -0.0469114469943097 0.565934557464627 0.289405818491864 0.00108094176374498 miRNAWalker2_validate -0.684221369690828 9.11032007486163e-38 NA NA NA hsa-miR-30d-3p ETS1 0.0854049347792898 0.20691254801121 0.289405818491864 0.00108094176374498 mirMAP -0.19488681319968 0.000307182896994994 NA NA NA hsa-miR-30e-3p ETS1 0.00173769765874887 0.984965501547409 0.289405818491864 0.00108094176374498 mirMAP -0.429297983437924 2.38065263035272e-16 NA NA NA hsa-miR-330-5p ETS1 -0.262932095995605 0.0465226565966658 0.289405818491864 0.00108094176374498 MirTarget;miRanda -0.127388187945365 3.03085919315415e-06 NA NA NA hsa-miR-338-3p ETS1 -0.39963704679384 0.0034410643220691 0.289405818491864 0.00108094176374498 MirTarget;PITA;miRanda;miRNATAP -0.141646578198775 9.45149495322417e-07 NA NA NA hsa-miR-365a-3p ETS1 -0.184222766207919 0.0292663235724171 0.289405818491864 0.00108094176374498 MirTarget -0.313168336538666 3.75956786879305e-13 NA NA NA hsa-miR-421 ETS1 -0.171573235029879 0.0518112933651029 0.289405818491864 0.00108094176374498 miRanda;mirMAP;miRNATAP -0.301443970155247 8.13096801821041e-14 NA NA NA hsa-miR-455-5p ETS1 0.332224239762 0.0106491358056238 0.289405818491864 0.00108094176374498 MirTarget;PITA;miRanda;miRNATAP -0.191919507098968 2.22988888462024e-12 NA NA NA hsa-miR-491-5p ETS1 -0.749881113074983 8.22859263179194e-09 0.289405818491864 0.00108094176374498 miRanda -0.181350131670386 1.34783724127096e-11 NA NA NA hsa-miR-495-3p ETS1 -0.421982588962504 0.00504424038526901 0.289405818491864 0.00108094176374498 MirTarget -0.150335068648095 2.5024087000222e-10 NA NA NA hsa-miR-501-5p ETS1 0.0878951859817452 0.309663377222443 0.289405818491864 0.00108094176374498 mirMAP -0.209582683021753 5.31312301430118e-07 NA NA NA hsa-miR-532-3p ETS1 0.150624483952741 0.0599635132177191 0.289405818491864 0.00108094176374498 MirTarget;PITA;miRNATAP -0.145479713510489 0.00194959146192052 NA NA NA hsa-miR-543 ETS1 -0.347737549779625 0.0157394585079683 0.289405818491864 0.00108094176374498 PITA;miRanda;mirMAP -0.157078142260562 5.70058038158301e-10 NA NA NA hsa-miR-576-5p ETS1 0.106482276040047 0.194379152564166 0.289405818491864 0.00108094176374498 mirMAP -0.259714644929324 4.46679103791945e-09 NA NA NA hsa-miR-590-3p ETS1 0.312951515438396 0.000480455423843996 0.289405818491864 0.00108094176374498 PITA;miRanda;mirMAP -0.141713986573881 0.000443074580584698 NA NA NA hsa-miR-590-5p ETS1 0.16946027035949 0.0386004382081678 0.289405818491864 0.00108094176374498 miRanda -0.241448072925607 5.15948089423339e-08 NA NA NA hsa-miR-625-3p ETS1 -0.0638840950852737 0.547354471747105 0.289405818491864 0.00108094176374498 mirMAP -0.231986999088387 1.74051733185674e-11 NA NA NA hsa-miR-625-5p ETS1 -0.0264137834407145 0.802098211251158 0.289405818491864 0.00108094176374498 MirTarget -0.137836151248644 6.28736661705071e-05 NA NA NA hsa-miR-660-5p ETS1 -0.138989893523975 0.0945491063873448 0.289405818491864 0.00108094176374498 MirTarget -0.196414838895507 3.04766461081467e-05 NA NA NA hsa-miR-664a-3p ETS1 0.0413918462467198 0.611334357897022 0.289405818491864 0.00108094176374498 mirMAP -0.269328479935427 2.52724805791813e-09 NA NA NA hsa-miR-7-1-3p ETS1 -0.0894475316162393 0.37322359785108 0.289405818491864 0.00108094176374498 mirMAP -0.245117818685193 6.78248936431187e-12 NA NA NA hsa-miR-766-3p ETS1 -0.147747825439875 0.266658981351507 0.289405818491864 0.00108094176374498 MirTarget -0.131167739545701 9.97604637097686e-07 NA NA NA hsa-miR-769-5p ETS1 -0.320572895263071 0.00425481410304398 0.289405818491864 0.00108094176374498 miRNATAP -0.260205900906852 6.0200361865635e-16 NA NA NA hsa-miR-940 ETS1 -0.0183807673806575 0.881747775878136 0.289405818491864 0.00108094176374498 MirTarget;miRNATAP -0.109502787695634 0.0001762412840239 NA NA NA hsa-miR-320a ETS2 0.092135599636725 0.243028758989929 0.0683071248363474 0.293363725684847 miRanda;miRNATAP -0.186071783379914 1.6459537835723e-06 NA NA NA hsa-miR-9-3p ETS2 -0.184945845984695 0.0290051908009009 0.0683071248363474 0.293363725684847 miRNATAP -0.235706281681507 1.59440251216369e-09 NA NA NA hsa-let-7d-5p FGF11 0.111345229817909 0.0872634398336815 -0.235018569265848 0.00440939153265794 mirMAP;miRNATAP -0.539705813701275 3.46462978181246e-18 NA NA NA hsa-let-7e-5p FGF11 0.0471189209570344 0.657255455444655 -0.235018569265848 0.00440939153265794 mirMAP;miRNATAP -0.272669366101863 7.34562908174005e-14 NA NA NA hsa-let-7f-5p FGF11 0.0508269185845673 0.62677515045793 -0.235018569265848 0.00440939153265794 mirMAP;miRNATAP -0.15253479478004 0.000320003174670443 NA NA NA hsa-let-7g-5p FGF11 -0.0253396334608382 0.742556489443668 -0.235018569265848 0.00440939153265794 mirMAP;miRNATAP -0.256034055595292 6.39523006394648e-06 NA NA NA hsa-let-7i-5p FGF11 0.0952853587923244 0.192120688957249 -0.235018569265848 0.00440939153265794 miRNATAP -0.323507607251771 2.41702652033077e-08 NA NA NA hsa-miR-1226-3p FGF11 -0.098618802853881 0.346683714981524 -0.235018569265848 0.00440939153265794 mirMAP -0.215873498479599 8.3092578295701e-12 NA NA NA hsa-miR-125a-3p FGF11 0.183834985432376 0.106230647107917 -0.235018569265848 0.00440939153265794 miRanda -0.220387739616411 4.2677254499296e-14 NA NA NA hsa-miR-125a-5p FGF11 -0.0833349424517387 0.325440200253607 -0.235018569265848 0.00440939153265794 mirMAP -0.399141179421754 4.42388956486495e-17 NA NA NA hsa-miR-125b-5p FGF11 -0.0119698382910496 0.890233923197358 -0.235018569265848 0.00440939153265794 mirMAP -0.300364716646036 2.460478659499e-07 NA NA NA hsa-miR-130b-5p FGF11 0.413070888963592 1.98866876365509e-06 -0.235018569265848 0.00440939153265794 mirMAP -0.129307922513196 0.00115639283572434 NA NA NA hsa-miR-15b-3p FGF11 0.690804403863844 8.48784755123775e-09 -0.235018569265848 0.00440939153265794 MirTarget -0.238742383514492 2.59789395249708e-19 NA NA NA hsa-miR-16-5p FGF11 0.246024668671282 0.00346042804503716 -0.235018569265848 0.00440939153265794 mirMAP -0.253885121824312 5.44203675685023e-08 NA NA NA hsa-miR-181a-5p FGF11 -0.178215604431845 0.0700010802255601 -0.235018569265848 0.00440939153265794 mirMAP -0.121480612085174 0.00953424365553838 NA NA NA hsa-miR-181b-5p FGF11 0.0260899284211646 0.768941836912518 -0.235018569265848 0.00440939153265794 mirMAP -0.216091901390167 4.37071492449882e-06 NA NA NA hsa-miR-193b-3p FGF11 0.0766333116224072 0.324723824453143 -0.235018569265848 0.00440939153265794 miRNAWalker2_validate -0.163790513828313 0.000308059901870561 NA NA NA hsa-miR-199a-5p FGF11 0.174889610847968 0.0900027418912454 -0.235018569265848 0.00440939153265794 miRanda -0.123545036604956 0.000174808908676321 NA NA NA hsa-miR-199b-5p FGF11 0.436298593972862 0.00200225454383871 -0.235018569265848 0.00440939153265794 miRanda -0.16382095505275 1.58231259921081e-12 NA NA NA hsa-miR-2355-5p FGF11 0.00808596988211185 0.916165501155096 -0.235018569265848 0.00440939153265794 mirMAP -0.404493707556144 9.44226447177025e-20 NA NA NA hsa-miR-28-5p FGF11 0.104003572105781 0.153594705579534 -0.235018569265848 0.00440939153265794 miRanda -0.300015659036983 9.49162856500363e-10 NA NA NA hsa-miR-30c-1-3p FGF11 0.0175008295781193 0.849381871022214 -0.235018569265848 0.00440939153265794 MirTarget -0.231888561690859 2.21641993413236e-10 NA NA NA hsa-miR-3127-5p FGF11 -0.0645479321229978 0.382330591204685 -0.235018569265848 0.00440939153265794 MirTarget -0.338870271012372 5.37567519810833e-14 NA NA NA hsa-miR-320c FGF11 0.343259124189966 0.000248338401291051 -0.235018569265848 0.00440939153265794 miRanda -0.104283413045425 0.00462086226364477 NA NA NA hsa-miR-324-5p FGF11 0.0183370482495953 0.842996782677271 -0.235018569265848 0.00440939153265794 miRanda -0.36724232915858 4.00522299245935e-25 NA NA NA hsa-miR-330-5p FGF11 -0.262932095995605 0.0465226565966658 -0.235018569265848 0.00440939153265794 MirTarget;PITA;miRanda;miRNATAP -0.195003196729419 3.80014150378446e-15 NA NA NA hsa-miR-331-3p FGF11 0.0126984726684189 0.905175053956974 -0.235018569265848 0.00440939153265794 miRNATAP -0.248282800419238 1.47164026963049e-15 NA NA NA hsa-miR-335-5p FGF11 0.0938511632756978 0.336889056387694 -0.235018569265848 0.00440939153265794 miRNAWalker2_validate;mirMAP -0.102652960252214 0.00341885696268571 NA NA NA hsa-miR-339-5p FGF11 0.273253751377152 0.0185300170790638 -0.235018569265848 0.00440939153265794 miRanda -0.192448682459769 1.30310049315034e-11 NA NA NA hsa-miR-432-5p FGF11 -0.214242438141977 0.166186087759946 -0.235018569265848 0.00440939153265794 mirMAP -0.188236536467299 2.1710514664352e-19 NA NA NA hsa-miR-532-3p FGF11 0.150624483952741 0.0599635132177191 -0.235018569265848 0.00440939153265794 mirMAP -0.160139075795999 0.0002261365465316 NA NA NA hsa-miR-548b-3p FGF11 0.340474544210108 0.00224491592019745 -0.235018569265848 0.00440939153265794 mirMAP -0.256817435326662 3.55493816294849e-18 NA NA NA hsa-miR-628-5p FGF11 -0.0469793532265896 0.657420003383685 -0.235018569265848 0.00440939153265794 miRNATAP -0.294133448795464 4.10014422796776e-21 NA NA NA hsa-miR-142-5p FGF12 0.434884875454107 0.000575570345702788 -0.341174347829348 0.00108179644535172 miRNATAP -0.221343945375644 9.7510045039636e-11 NA NA NA hsa-miR-200b-3p FGF12 0.245768526504511 0.0580744465744737 -0.341174347829348 0.00108179644535172 TargetScan -0.282089673650438 6.08610087552928e-17 NA NA NA hsa-miR-217 FGF12 0.540279882451941 0.00312206944061206 -0.341174347829348 0.00108179644535172 miRanda -0.180715339357903 1.50784321290264e-14 NA NA NA hsa-miR-2355-3p FGF12 0.186207523505296 0.0525918026993012 -0.341174347829348 0.00108179644535172 MirTarget;miRNATAP -0.231026550449217 3.7230945566169e-07 NA NA NA hsa-miR-3065-5p FGF12 -0.262608140481507 0.0414570974148034 -0.341174347829348 0.00108179644535172 mirMAP -0.1013901905804 0.00321299126471714 NA NA NA hsa-miR-335-3p FGF12 0.34540584335595 0.00043848660222294 -0.341174347829348 0.00108179644535172 MirTarget -0.150595502597158 0.00121258088251763 NA NA NA hsa-miR-362-3p FGF12 0.032375035235532 0.736465332563774 -0.341174347829348 0.00108179644535172 miRanda -0.173543809213136 0.000157836462891801 NA NA NA hsa-miR-3682-3p FGF12 0.113471485204649 0.266481019608971 -0.341174347829348 0.00108179644535172 MirTarget -0.262952473970731 2.37222373386136e-09 NA NA NA hsa-miR-455-5p FGF12 0.332224239762 0.0106491358056238 -0.341174347829348 0.00108179644535172 miRanda -0.224899082272953 1.63021966242583e-11 NA NA NA hsa-miR-501-5p FGF12 0.0878951859817452 0.309663377222443 -0.341174347829348 0.00108179644535172 MirTarget;PITA -0.257820236542007 4.14825558157776e-07 NA NA NA hsa-miR-542-3p FGF12 0.0835995677900829 0.403838744494071 -0.341174347829348 0.00108179644535172 miRanda -0.215735316621216 9.2374079674621e-06 NA NA NA hsa-miR-576-5p FGF12 0.106482276040047 0.194379152564166 -0.341174347829348 0.00108179644535172 mirMAP -0.290746464930981 7.73109194139942e-08 NA NA NA hsa-miR-590-3p FGF12 0.312951515438396 0.000480455423843996 -0.341174347829348 0.00108179644535172 mirMAP -0.29979405572985 6.75200328981588e-10 NA NA NA hsa-miR-1262 FGF13 0.276259331706731 0.0259799942226561 -0.706826351179643 1.15125565809917e-06 MirTarget;PITA;miRNATAP -0.343876045827969 2.47310188991752e-11 NA NA NA hsa-miR-141-3p FGF13 0.41120561991992 0.000393344390969055 -0.706826351179643 1.15125565809917e-06 TargetScan -0.224532540308352 5.58413842670053e-05 NA NA NA hsa-miR-142-5p FGF13 0.434884875454107 0.000575570345702788 -0.706826351179643 1.15125565809917e-06 PITA -0.291867410048386 3.93193139922811e-09 NA NA NA hsa-miR-34c-5p FGF13 0.181931113688093 0.257266965617363 -0.706826351179643 1.15125565809917e-06 miRanda -0.119115228141567 0.00246321570966122 NA NA NA hsa-miR-3682-3p FGF13 0.113471485204649 0.266481019608971 -0.706826351179643 1.15125565809917e-06 MirTarget -0.336026296198332 1.42601055678693e-07 NA NA NA hsa-miR-455-5p FGF13 0.332224239762 0.0106491358056238 -0.706826351179643 1.15125565809917e-06 PITA;miRanda -0.228084495997694 2.90950842226493e-06 NA NA NA hsa-miR-542-3p FGF13 0.0835995677900829 0.403838744494071 -0.706826351179643 1.15125565809917e-06 miRanda -0.249164166181018 0.000410048353399803 NA NA NA hsa-miR-548b-3p FGF13 0.340474544210108 0.00224491592019745 -0.706826351179643 1.15125565809917e-06 PITA -0.208062810230116 0.000321083900949721 NA NA NA hsa-miR-590-3p FGF13 0.312951515438396 0.000480455423843996 -0.706826351179643 1.15125565809917e-06 miRanda -0.476448111326993 9.26782882672395e-12 NA NA NA hsa-miR-125a-3p FGF14 0.183834985432376 0.106230647107917 -0.398515744120357 0.000209763793404898 miRanda -0.18209547085274 8.59757723382675e-06 NA NA NA hsa-miR-193a-5p FGF14 0.183172152450491 0.0749251910521214 -0.398515744120357 0.000209763793404898 TargetScan -0.245243369908449 9.67804779852833e-08 NA NA NA hsa-miR-362-3p FGF14 0.032375035235532 0.736465332563774 -0.398515744120357 0.000209763793404898 miRanda -0.188865716800422 8.54829762691488e-05 NA NA NA hsa-miR-421 FGF14 -0.171573235029879 0.0518112933651029 -0.398515744120357 0.000209763793404898 miRanda -0.253745288160661 1.23339623348382e-06 NA NA NA hsa-miR-590-3p FGF14 0.312951515438396 0.000480455423843996 -0.398515744120357 0.000209763793404898 miRanda -0.301628753406604 3.20594125245951e-09 NA NA NA hsa-miR-331-3p FGF17 0.0126984726684189 0.905175053956974 -0.747209687668737 1.81064553707654e-05 mirMAP -0.337058286685929 3.52810699933431e-06 NA NA NA hsa-let-7a-3p FGF2 0.0530563276543763 0.370749834463566 -0.310412510487203 1.0531264899139e-05 mirMAP -0.213352464353633 3.01948138253891e-05 NA NA NA hsa-let-7f-1-3p FGF2 0.110713086694053 0.21484524300518 -0.310412510487203 1.0531264899139e-05 mirMAP -0.103512481979716 0.000647773517119759 NA NA NA hsa-miR-103a-3p FGF2 -0.147443193527362 0.128400914654149 -0.310412510487203 1.0531264899139e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.12655516361281 0.00679371182948832 NA NA NA hsa-miR-126-5p FGF2 0.177332403948664 0.0711675116243123 -0.310412510487203 1.0531264899139e-05 mirMAP -0.110162176340636 0.000136298645021207 NA NA NA hsa-miR-140-5p FGF2 0.065063507103468 0.380452509211773 -0.310412510487203 1.0531264899139e-05 miRNAWalker2_validate -0.185361566298031 2.74319630927397e-06 NA NA NA hsa-miR-146a-5p FGF2 0.148942451196282 0.114229072828724 -0.310412510487203 1.0531264899139e-05 mirMAP -0.146277493567259 4.31070451040202e-07 NA NA NA hsa-miR-15a-5p FGF2 0.142658985373611 0.0536219185009004 -0.310412510487203 1.0531264899139e-05 MirTarget;miRNATAP -0.207678236164206 2.5972218474549e-06 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 0.690804403863844 8.48784755123775e-09 -0.310412510487203 1.0531264899139e-05 mirMAP -0.137724123749645 3.22216944518618e-10 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 0.592863156692837 1.41971517354055e-10 -0.310412510487203 1.0531264899139e-05 MirTarget;miRNATAP -0.259712883212368 3.66212966170394e-18 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-2-3p FGF2 0.468816222075619 7.04377763166292e-05 -0.310412510487203 1.0531264899139e-05 mirMAP -0.160896949653708 5.53366478735585e-13 NA NA NA hsa-miR-16-5p FGF2 0.246024668671282 0.00346042804503716 -0.310412510487203 1.0531264899139e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.238035584676493 2.36870334343313e-10 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-181a-5p FGF2 -0.178215604431845 0.0700010802255601 -0.310412510487203 1.0531264899139e-05 mirMAP -0.123717144171581 0.00107047935591826 NA NA NA hsa-miR-181b-5p FGF2 0.0260899284211646 0.768941836912518 -0.310412510487203 1.0531264899139e-05 mirMAP -0.215729610871528 1.18634456085395e-08 NA NA NA hsa-miR-19b-1-5p FGF2 0.0686579042235509 0.332645627997485 -0.310412510487203 1.0531264899139e-05 mirMAP -0.201459709129831 1.90976689008877e-07 NA NA NA hsa-miR-20a-3p FGF2 0.102743778777997 0.19677865359751 -0.310412510487203 1.0531264899139e-05 mirMAP -0.144973090746876 2.52878071686245e-05 NA NA NA hsa-miR-335-3p FGF2 0.34540584335595 0.00043848660222294 -0.310412510487203 1.0531264899139e-05 mirMAP -0.178439766262418 2.49255926048001e-10 NA NA NA hsa-miR-335-5p FGF2 0.0938511632756978 0.336889056387694 -0.310412510487203 1.0531264899139e-05 miRNATAP -0.140124965064104 6.34697534647765e-07 NA NA NA hsa-miR-361-5p FGF2 0.0107519600643302 0.882230614095565 -0.310412510487203 1.0531264899139e-05 mirMAP -0.181723993106071 8.88544014107461e-05 NA NA NA hsa-miR-376a-5p FGF2 -0.0877544252790136 0.551096721204598 -0.310412510487203 1.0531264899139e-05 mirMAP -0.113264250236629 1.03177567762586e-09 NA NA NA hsa-miR-376c-3p FGF2 -0.0513360810290662 0.710610589791979 -0.310412510487203 1.0531264899139e-05 mirMAP -0.132449788888867 7.98306703791068e-12 NA NA NA hsa-miR-424-5p FGF2 0.25140374049676 0.00709934939774983 -0.310412510487203 1.0531264899139e-05 MirTarget;miRNATAP -0.137720507275413 5.34564200507529e-06 NA NA NA hsa-miR-450b-5p FGF2 0.270544879013992 0.00801537838499562 -0.310412510487203 1.0531264899139e-05 mirMAP -0.1181608495248 1.10414336833114e-05 NA NA NA hsa-miR-92a-3p FGF2 0.0407239381334659 0.643983393805961 -0.310412510487203 1.0531264899139e-05 miRNAWalker2_validate -0.244288015297521 5.53502580269543e-07 NA NA NA hsa-miR-93-3p FGF2 0.0778767956494004 0.272224943247293 -0.310412510487203 1.0531264899139e-05 mirMAP -0.195143626431712 9.46174309952938e-07 NA NA NA hsa-miR-320a FGF7 0.092135599636725 0.243028758989929 -0.109502517174931 0.0871753790241782 miRanda -0.189627649950838 1.75375340223191e-05 NA NA NA hsa-miR-142-3p FGF9 0.558908907203977 1.37828834702416e-05 -0.595722923032546 5.09639453585729e-05 miRanda -0.282659516489835 3.27499478623632e-08 NA NA NA hsa-miR-142-5p FGF9 0.434884875454107 0.000575570345702788 -0.595722923032546 5.09639453585729e-05 mirMAP -0.263556678906143 1.6968256051013e-07 NA NA NA hsa-miR-155-5p FGF9 0.969837380981085 5.86551495710056e-15 -0.595722923032546 5.09639453585729e-05 miRNATAP -0.453780730649256 1.65025963862586e-20 NA NA NA hsa-miR-15a-5p FGF9 0.142658985373611 0.0536219185009004 -0.595722923032546 5.09639453585729e-05 miRNATAP -0.275420422702668 0.00935039740726957 NA NA NA hsa-miR-15b-5p FGF9 0.592863156692837 1.41971517354055e-10 -0.595722923032546 5.09639453585729e-05 miRNATAP -0.404611884080866 2.58313582119002e-08 NA NA NA hsa-miR-186-5p FGF9 0.0606381894130505 0.514217717592464 -0.595722923032546 5.09639453585729e-05 mirMAP -0.250823884564551 0.00106977407353773 NA NA NA hsa-miR-195-3p FGF9 0.100105455903079 0.133362389112338 -0.595722923032546 5.09639453585729e-05 mirMAP;miRNATAP -0.574940764738145 5.84660729823155e-09 NA NA NA hsa-miR-195-5p FGF9 -0.00728332132631593 0.92969850577609 -0.595722923032546 5.09639453585729e-05 miRNATAP -0.24382643607404 0.00409105332090611 NA NA NA hsa-miR-30a-3p FGF9 0.0655410309550977 0.509541256241954 -0.595722923032546 5.09639453585729e-05 mirMAP -0.555169048587157 2.90091683073997e-11 NA NA NA hsa-miR-30d-3p FGF9 0.0854049347792898 0.20691254801121 -0.595722923032546 5.09639453585729e-05 mirMAP -0.289322511444801 0.00271338910608715 NA NA NA hsa-miR-30e-3p FGF9 0.00173769765874887 0.984965501547409 -0.595722923032546 5.09639453585729e-05 mirMAP -0.277338182293572 0.00386198649418057 NA NA NA hsa-miR-320a FGF9 0.092135599636725 0.243028758989929 -0.595722923032546 5.09639453585729e-05 mirMAP;miRNATAP -0.59157746030768 5.35123905548572e-09 NA NA NA hsa-miR-320b FGF9 0.283477746304177 0.0005953763020907 -0.595722923032546 5.09639453585729e-05 mirMAP;miRNATAP -0.390562222089067 4.68249121043252e-07 NA NA NA hsa-miR-320c FGF9 0.343259124189966 0.000248338401291051 -0.595722923032546 5.09639453585729e-05 mirMAP;miRNATAP -0.476602977693011 7.45109251212317e-12 NA NA NA hsa-miR-374a-5p FGF9 0.0121037060909277 0.865417963345881 -0.595722923032546 5.09639453585729e-05 mirMAP -0.347418722893837 0.000370519855560241 NA NA NA hsa-miR-424-5p FGF9 0.25140374049676 0.00709934939774983 -0.595722923032546 5.09639453585729e-05 miRNATAP -0.323788407456984 7.04548719212049e-06 NA NA NA hsa-miR-450b-5p FGF9 0.270544879013992 0.00801537838499562 -0.595722923032546 5.09639453585729e-05 mirMAP;miRNATAP -0.170139909599057 0.00822509033990335 NA NA NA hsa-miR-455-5p FGF9 0.332224239762 0.0106491358056238 -0.595722923032546 5.09639453585729e-05 miRanda -0.20501240822684 3.46032555683183e-05 NA NA NA hsa-miR-500a-5p FGF9 0.0634452729978863 0.396072382601677 -0.595722923032546 5.09639453585729e-05 miRNATAP -0.343027613737247 7.65451782761426e-05 NA NA NA hsa-miR-501-3p FGF9 0.0726267165568464 0.382729320534971 -0.595722923032546 5.09639453585729e-05 miRNATAP -0.362505345443718 6.76645261427266e-06 NA NA NA hsa-miR-502-3p FGF9 0.0276791089364088 0.697605011368848 -0.595722923032546 5.09639453585729e-05 miRNATAP -0.337427005191369 0.000251687937385934 NA NA NA hsa-miR-548b-3p FGF9 0.340474544210108 0.00224491592019745 -0.595722923032546 5.09639453585729e-05 PITA;miRNATAP -0.216483740417717 0.000218504203688734 NA NA NA hsa-miR-590-3p FGF9 0.312951515438396 0.000480455423843996 -0.595722923032546 5.09639453585729e-05 miRanda;mirMAP -0.361438804031195 4.29572281799449e-07 NA NA NA hsa-miR-590-5p FGF9 0.16946027035949 0.0386004382081678 -0.595722923032546 5.09639453585729e-05 miRanda -0.321536756569473 5.33163773528782e-05 NA NA NA hsa-miR-106b-5p FGFR1 0.167096183547615 0.0497544396383451 0.192963212582154 0.0114476358485445 mirMAP -0.131235051348832 0.00142331370486675 NA NA NA hsa-miR-135a-5p FGFR1 -0.122734612943241 0.196985964641886 0.192963212582154 0.0114476358485445 mirMAP -0.267076393133823 3.49512278163343e-16 NA NA NA hsa-miR-17-5p FGFR1 0.0975751369167082 0.20621110214601 0.192963212582154 0.0114476358485445 mirMAP -0.17274697976655 0.000506163795302763 NA NA NA hsa-miR-20a-5p FGFR1 -0.0115865752288853 0.887069448776018 0.192963212582154 0.0114476358485445 mirMAP -0.126433668888031 0.00557452572524836 NA NA NA hsa-miR-301a-3p FGFR1 0.00956875714542704 0.916380325220259 0.192963212582154 0.0114476358485445 mirMAP -0.276045190623239 1.48240939059687e-15 NA NA NA hsa-miR-3065-5p FGFR1 -0.262608140481507 0.0414570974148034 0.192963212582154 0.0114476358485445 mirMAP -0.16049264076124 1.15527531166031e-11 NA NA NA hsa-miR-19b-1-5p FGFR2 0.0686579042235509 0.332645627997485 -0.492577222868217 7.16897440371588e-05 miRNAWalker2_validate;miRTarBase -0.219237513523795 0.00418312265430993 NA NA NA hsa-miR-767-3p FGFR2 -0.429854368420513 0.000821445291167688 -0.492577222868217 7.16897440371588e-05 miRNATAP -0.194318397286558 3.97094001404658e-06 NA NA NA hsa-miR-19a-3p FGFR3 0.0466707843731911 0.576818938277755 -0.365042106979193 0.0162579686859603 mirMAP -0.403607035817958 7.63620881302308e-07 NA NA NA hsa-miR-19b-3p FGFR3 -0.0138427450847924 0.856506310673067 -0.365042106979193 0.0162579686859603 mirMAP -0.493984491016398 3.76125674952932e-07 NA NA NA hsa-miR-423-5p FGFR3 0.0965587900813789 0.148039180704338 -0.365042106979193 0.0162579686859603 MirTarget -0.461369327046826 2.91582172960651e-05 NA NA NA hsa-miR-326 FGFR4 -0.631050656251074 8.83643450601471e-05 -0.113755549365812 0.272566172396588 miRanda;miRNATAP -0.114644354916499 3.71049779113221e-05 NA NA NA hsa-miR-330-5p FGFR4 -0.262932095995605 0.0465226565966658 -0.113755549365812 0.272566172396588 miRanda;miRNATAP -0.162111818201426 2.05395711443048e-06 NA NA NA hsa-miR-491-5p FGFR4 -0.749881113074983 8.22859263179194e-09 -0.113755549365812 0.272566172396588 miRanda -0.122513697865613 0.000325785696471828 NA NA NA hsa-miR-200c-3p FLT1 0.413752622631695 8.6936333715621e-06 -0.0319580376334354 0.638676444552897 miRNAWalker2_validate;miRTarBase;MirTarget -0.106974186068777 0.000164134588758016 NA NA NA hsa-miR-93-5p FLT1 0.139766237971122 0.101057320076629 -0.0319580376334354 0.638676444552897 MirTarget;miRNATAP -0.237915238868615 6.25267586077392e-07 NA NA NA hsa-miR-491-5p FLT3LG -0.749881113074983 8.22859263179194e-09 0.250297199383235 0.00163133237530921 miRanda -0.19120255383897 4.59275417136434e-14 NA NA NA hsa-miR-326 FLT4 -0.631050656251074 8.83643450601471e-05 0.554297297147832 5.7853410758179e-11 mirMAP -0.112312658890302 7.44447214226844e-07 NA NA NA hsa-miR-331-3p FLT4 0.0126984726684189 0.905175053956974 0.554297297147832 5.7853410758179e-11 miRNAWalker2_validate -0.107717555222326 0.0023064210022874 NA NA NA hsa-miR-374a-5p FLT4 0.0121037060909277 0.865417963345881 0.554297297147832 5.7853410758179e-11 mirMAP -0.146783413937602 0.00909737149679747 NA NA NA hsa-miR-374b-5p FLT4 -0.210113949579608 0.0056866083818614 0.554297297147832 5.7853410758179e-11 mirMAP -0.179968740329611 0.00118087660409241 NA NA NA hsa-miR-491-5p FLT4 -0.749881113074983 8.22859263179194e-09 0.554297297147832 5.7853410758179e-11 miRanda -0.207101502868985 3.6785195251628e-14 NA NA NA hsa-miR-20b-3p FOXO4 0.362644372373256 0.000173241009721294 -0.36005146681592 2.60919329493906e-08 MirTarget -0.149802112233519 1.5783522049997e-08 NA NA NA hsa-miR-106a-5p GAB1 0.110074064773897 0.13045815990621 0.0446393127035822 0.47458917429822 MirTarget;miRNATAP -0.158044885434852 9.13163491277766e-07 NA NA NA hsa-miR-132-3p GAB1 -0.178379362833856 0.13335200877129 0.0446393127035822 0.47458917429822 mirMAP -0.130504601044583 2.18681261321527e-11 NA NA NA hsa-miR-153-3p GAB1 -0.173449510253619 0.0654368045743418 0.0446393127035822 0.47458917429822 MirTarget -0.115717854421047 2.26511493919251e-06 NA NA NA hsa-miR-20b-5p GAB1 0.144541062989476 0.0992042333556543 0.0446393127035822 0.47458917429822 MirTarget;miRNATAP -0.115288508385211 2.34354364895231e-05 NA NA NA hsa-miR-221-3p GAB1 -0.0109507285071775 0.936440693394519 0.0446393127035822 0.47458917429822 MirTarget;miRNATAP -0.117066011247107 2.97654053312292e-13 NA NA NA hsa-miR-222-3p GAB1 0.107117065575197 0.423818119725697 0.0446393127035822 0.47458917429822 MirTarget;miRNATAP -0.120202710568691 1.14809171122041e-13 NA NA NA hsa-miR-299-5p GAB1 -0.0814737109317336 0.57620244226785 0.0446393127035822 0.47458917429822 MirTarget -0.102150905404053 1.75435370455862e-11 NA NA NA hsa-miR-29b-1-5p GAB1 0.191335428755774 0.00846436454790702 0.0446393127035822 0.47458917429822 mirMAP -0.125647394833141 3.7570130702129e-05 NA NA NA hsa-miR-29b-3p GAB1 -0.178522712044497 0.0856106432165465 0.0446393127035822 0.47458917429822 MirTarget -0.129594197613515 5.00191188482429e-08 NA NA NA hsa-miR-29c-3p GAB1 -0.372180390387259 0.00202634431973208 0.0446393127035822 0.47458917429822 MirTarget -0.104295424716652 2.17306783908999e-07 NA NA NA hsa-miR-30a-5p GAB1 -0.062942936611238 0.513851954700252 0.0446393127035822 0.47458917429822 mirMAP -0.154254175654158 5.02361053254248e-05 NA NA NA hsa-miR-30b-5p GAB1 -0.0858101016322106 0.263243418521854 0.0446393127035822 0.47458917429822 mirMAP -0.162498422076976 3.03410828657961e-06 NA NA NA hsa-miR-30c-5p GAB1 -0.0469114469943097 0.565934557464627 0.0446393127035822 0.47458917429822 mirMAP -0.133084569110297 0.000147783877030745 NA NA NA hsa-miR-335-3p GAB1 0.34540584335595 0.00043848660222294 0.0446393127035822 0.47458917429822 mirMAP -0.109338995606134 2.73354893962168e-06 NA NA NA hsa-miR-34a-5p GAB1 0.143472919835524 0.211283228567057 0.0446393127035822 0.47458917429822 MirTarget -0.133002597946856 9.8392251901014e-12 NA NA NA hsa-miR-361-5p GAB1 0.0107519600643302 0.882230614095565 0.0446393127035822 0.47458917429822 mirMAP;miRNATAP -0.126684825195895 0.000879732789538609 NA NA NA hsa-miR-409-3p GAB1 0.00456692516634361 0.974143243758506 0.0446393127035822 0.47458917429822 mirMAP -0.101740740499533 6.04811713983982e-11 25991585 MicroRNA 409 3p suppresses colorectal cancer invasion and metastasis partly by targeting GAB1 expression; However endogenous expression analysis revealed that only GAB1 was modulated by miR-409-3p in CRC cells at both the mRNA and protein levels; Taken together our data demonstrate that miR-409-3p is a metastatic suppressor and post-transcriptional inhibition of the oncoprotein GAB1 is one of the mechanisms of action of this miRNA metastasis colorectal cancer hsa-miR-508-3p GAB1 -0.292045725850845 0.0158994578296519 0.0446393127035822 0.47458917429822 MirTarget -0.131159602309068 2.42812396898827e-13 NA NA NA hsa-miR-509-3p GAB1 -0.145245599977929 0.22998447829194 0.0446393127035822 0.47458917429822 PITA -0.120927669406737 9.18512244911155e-11 NA NA NA hsa-miR-543 GAB1 -0.347737549779625 0.0157394585079683 0.0446393127035822 0.47458917429822 MirTarget;miRanda -0.11404321669971 1.5177829927717e-13 NA NA NA hsa-miR-664a-3p GAB1 0.0413918462467198 0.611334357897022 0.0446393127035822 0.47458917429822 MirTarget -0.203494955145764 1.35324022851017e-13 NA NA NA hsa-miR-7-1-3p GAB1 -0.0894475316162393 0.37322359785108 0.0446393127035822 0.47458917429822 mirMAP -0.193641097613724 3.01182390102859e-19 NA NA NA hsa-let-7d-5p GAB2 0.111345229817909 0.0872634398336815 -0.0543401151024536 0.357069218705564 MirTarget -0.120691627756661 0.00165698887186667 NA NA NA hsa-miR-125a-5p GAB2 -0.0833349424517387 0.325440200253607 -0.0543401151024536 0.357069218705564 mirMAP -0.116783031255106 6.40281701835104e-05 NA NA NA hsa-miR-361-3p GAB2 -0.0798653643614555 0.271064714084553 -0.0543401151024536 0.357069218705564 MirTarget;mirMAP -0.109873303607779 0.000545678311626507 NA NA NA hsa-miR-592 GAB2 0.0170005651576508 0.876633091134809 -0.0543401151024536 0.357069218705564 PITA;miRNATAP -0.126548606513111 2.52755294461082e-12 NA NA NA hsa-miR-664a-5p GAB2 0.0825994937558296 0.264421724444089 -0.0543401151024536 0.357069218705564 mirMAP -0.109903511423712 5.37440995165849e-05 NA NA NA hsa-miR-148b-5p GNB3 0.127111784487801 0.188731110216917 -0.200475968444105 0.0980037569221162 mirMAP -0.170907126929864 0.00205527892851483 NA NA NA hsa-miR-185-5p GNB3 -0.0767432095218297 0.404113540276816 -0.200475968444105 0.0980037569221162 MirTarget -0.350951449378987 5.0980376157585e-09 NA NA NA hsa-miR-320c GNB3 0.343259124189966 0.000248338401291051 -0.200475968444105 0.0980037569221162 miRanda -0.16943532624124 0.00344938213267382 NA NA NA hsa-miR-326 GNB3 -0.631050656251074 8.83643450601471e-05 -0.200475968444105 0.0980037569221162 miRanda -0.204318288235424 1.74539083197983e-10 NA NA NA hsa-miR-330-5p GNB3 -0.262932095995605 0.0465226565966658 -0.200475968444105 0.0980037569221162 miRanda -0.291053632628046 1.06919259567426e-13 NA NA NA hsa-miR-3622a-3p GNB3 0.0389203848593471 0.75605812962459 -0.200475968444105 0.0980037569221162 MirTarget -0.186856804314403 1.29452494634347e-05 NA NA NA hsa-miR-491-5p GNB3 -0.749881113074983 8.22859263179194e-09 -0.200475968444105 0.0980037569221162 miRanda -0.195806239369304 7.10351809231669e-07 NA NA NA hsa-miR-124-3p GNB4 -0.506026514549291 0.0078056370358648 0.153297566354816 0.0400115629824281 miRNAWalker2_validate -0.131140955047842 6.75556833257927e-21 NA NA NA hsa-miR-126-5p GNB4 0.177332403948664 0.0711675116243123 0.153297566354816 0.0400115629824281 mirMAP -0.121210035252956 3.40200062231311e-05 NA NA NA hsa-miR-133a-3p GNB4 -0.335058908302964 0.0180402783121034 0.153297566354816 0.0400115629824281 MirTarget -0.169885848469042 7.95593247928864e-20 NA NA NA hsa-miR-140-3p GNB4 -0.123864258867705 0.14796686619449 0.153297566354816 0.0400115629824281 MirTarget -0.19467097315135 4.30818273896369e-06 NA NA NA hsa-miR-203a-3p GNB4 -0.393041310603753 0.0191851699904077 0.153297566354816 0.0400115629824281 MirTarget -0.153078007818523 1.69329606169838e-22 NA NA NA hsa-miR-22-3p GNB4 0.0277287593466351 0.809325106832648 0.153297566354816 0.0400115629824281 MirTarget -0.101055336198689 0.00234098975763222 NA NA NA hsa-miR-29a-3p GNB4 -0.224140851576083 0.0349516103550236 0.153297566354816 0.0400115629824281 MirTarget -0.182379972650402 5.26860205788969e-08 NA NA NA hsa-miR-29b-3p GNB4 -0.178522712044497 0.0856106432165465 0.153297566354816 0.0400115629824281 MirTarget -0.194183700087458 2.96384607574358e-11 NA NA NA hsa-miR-29c-3p GNB4 -0.372180390387259 0.00202634431973208 0.153297566354816 0.0400115629824281 miRNAWalker2_validate;MirTarget -0.192278267049938 4.04738685118877e-15 NA NA NA hsa-miR-376a-5p GNB4 -0.0877544252790136 0.551096721204598 0.153297566354816 0.0400115629824281 MirTarget -0.110374501495641 4.66722750951084e-09 NA NA NA hsa-miR-433-3p GNB4 -0.584416505057956 0.00091765848343232 0.153297566354816 0.0400115629824281 MirTarget -0.128530289019997 1.30123303986383e-17 NA NA NA hsa-miR-582-5p GNB4 -0.215764335500665 0.0760892640434509 0.153297566354816 0.0400115629824281 MirTarget -0.183154072041297 4.6953843858999e-17 NA NA NA hsa-miR-7-1-3p GNB4 -0.0894475316162393 0.37322359785108 0.153297566354816 0.0400115629824281 MirTarget -0.250546729361893 4.66743800449427e-21 NA NA NA hsa-miR-885-5p GNB4 -0.423614695846868 1.14213289528402e-05 0.153297566354816 0.0400115629824281 MirTarget;miRNATAP -0.241999022878104 1.09576413684103e-17 NA NA NA hsa-miR-17-5p GNB5 0.0975751369167082 0.20621110214601 -0.176987527760175 0.00848636179515386 TargetScan -0.171125811929169 7.57887177376407e-05 NA NA NA hsa-miR-26b-5p GNB5 -0.0984536538762768 0.231803769574623 -0.176987527760175 0.00848636179515386 miRNAWalker2_validate -0.15088278412361 0.000115102305086069 NA NA NA hsa-miR-27a-3p GNB5 0.303760032895792 0.00457375391189806 -0.176987527760175 0.00848636179515386 miRNAWalker2_validate -0.189689297874063 1.15859987745694e-12 NA NA NA hsa-miR-542-3p GNB5 0.0835995677900829 0.403838744494071 -0.176987527760175 0.00848636179515386 miRanda -0.147022743558303 6.85906650308223e-07 NA NA NA hsa-miR-590-3p GNB5 0.312951515438396 0.000480455423843996 -0.176987527760175 0.00848636179515386 miRanda -0.16141535470045 5.80090806605299e-08 NA NA NA hsa-miR-767-3p GNG12 -0.429854368420513 0.000821445291167688 0.604079373560736 2.54919131069303e-06 PITA -0.404877496894133 3.81038934768308e-21 NA NA NA hsa-miR-96-5p GNG12 -0.217255611810229 0.209932800103896 0.604079373560736 2.54919131069303e-06 TargetScan -0.15058114761266 3.24333049347937e-06 NA NA NA hsa-miR-23a-3p GNG2 0.334693010651106 0.00144448147063433 0.00351063454247402 0.966548731653393 miRNATAP -0.253131187007529 6.67474612570918e-13 NA NA NA hsa-miR-28-5p GNG2 0.104003572105781 0.153594705579534 0.00351063454247402 0.966548731653393 miRanda;miRNATAP -0.170279269302617 0.000515850023464009 NA NA NA hsa-miR-3065-5p GNG2 -0.262608140481507 0.0414570974148034 0.00351063454247402 0.966548731653393 mirMAP;miRNATAP -0.181512530166327 7.59037152884704e-13 NA NA NA hsa-miR-30a-3p GNG2 0.0655410309550977 0.509541256241954 0.00351063454247402 0.966548731653393 mirMAP -0.398727183054275 1.8714609324061e-21 NA NA NA hsa-miR-30a-5p GNG2 -0.062942936611238 0.513851954700252 0.00351063454247402 0.966548731653393 miRNAWalker2_validate -0.579564115517773 1.04038842793485e-26 NA NA NA hsa-miR-30e-3p GNG2 0.00173769765874887 0.984965501547409 0.00351063454247402 0.966548731653393 mirMAP -0.343798163156342 1.07805060505833e-12 NA NA NA hsa-miR-500a-5p GNG2 0.0634452729978863 0.396072382601677 0.00351063454247402 0.966548731653393 mirMAP -0.2486002427408 1.82665409646733e-08 NA NA NA hsa-miR-576-5p GNG2 0.106482276040047 0.194379152564166 0.00351063454247402 0.966548731653393 mirMAP -0.229024937823673 1.65490137171413e-08 NA NA NA hsa-miR-590-3p GNG2 0.312951515438396 0.000480455423843996 0.00351063454247402 0.966548731653393 PITA;miRanda;mirMAP;miRNATAP -0.154818384131202 2.62621267758204e-05 NA NA NA hsa-miR-590-5p GNG2 0.16946027035949 0.0386004382081678 0.00351063454247402 0.966548731653393 miRanda;miRNATAP -0.186355736940742 4.80428956994954e-06 NA NA NA hsa-miR-107 GNG4 -0.121070851008387 0.198381281894242 -0.10801241280425 0.28331338760809 miRanda -0.18035621056342 0.000112995726389046 NA NA NA hsa-miR-125b-1-3p GNG4 0.365273696139707 0.00135662312552206 -0.10801241280425 0.28331338760809 MirTarget -0.26559816361558 6.88175752276102e-14 NA NA NA hsa-miR-1262 GNG4 0.276259331706731 0.0259799942226561 -0.10801241280425 0.28331338760809 mirMAP -0.32857647294086 9.23024016629209e-24 NA NA NA hsa-miR-141-3p GNG4 0.41120561991992 0.000393344390969055 -0.10801241280425 0.28331338760809 mirMAP -0.289436691600956 3.24458620748744e-16 NA NA NA hsa-miR-142-5p GNG4 0.434884875454107 0.000575570345702788 -0.10801241280425 0.28331338760809 mirMAP -0.339582701158136 7.726707428435e-28 NA NA NA hsa-miR-193b-3p GNG4 0.0766333116224072 0.324723824453143 -0.10801241280425 0.28331338760809 mirMAP -0.19623840552173 0.000483500641926725 NA NA NA hsa-miR-199a-3p GNG4 0.41226331871076 0.000497136154474528 -0.10801241280425 0.28331338760809 mirMAP -0.229470659881092 5.47433779921279e-11 NA NA NA hsa-miR-199b-3p GNG4 0.411848361704393 0.000517815011892379 -0.10801241280425 0.28331338760809 mirMAP -0.228285015601119 6.25362988897028e-11 NA NA NA hsa-miR-200b-3p GNG4 0.245768526504511 0.0580744465744737 -0.10801241280425 0.28331338760809 mirMAP -0.323779873796933 3.05568652770626e-25 NA NA NA hsa-miR-200c-3p GNG4 0.413752622631695 8.6936333715621e-06 -0.10801241280425 0.28331338760809 mirMAP -0.418116775220357 1.48284068728311e-22 NA NA NA hsa-miR-23a-3p GNG4 0.334693010651106 0.00144448147063433 -0.10801241280425 0.28331338760809 mirMAP -0.56775723073173 1.22553214812867e-42 NA NA NA hsa-miR-23b-3p GNG4 0.0476610245860094 0.630277683372344 -0.10801241280425 0.28331338760809 mirMAP -0.395764115756776 4.16954647239402e-18 NA NA NA hsa-miR-25-3p GNG4 0.316649850160985 0.000777982468387578 -0.10801241280425 0.28331338760809 mirMAP -0.181872300717914 0.00162489919492468 NA NA NA hsa-miR-29a-5p GNG4 -0.0697727833812678 0.350621682973119 -0.10801241280425 0.28331338760809 mirMAP -0.346621546536048 6.33232844142113e-10 NA NA NA hsa-miR-3065-5p GNG4 -0.262608140481507 0.0414570974148034 -0.10801241280425 0.28331338760809 mirMAP -0.211118953557085 3.38535632197126e-11 NA NA NA hsa-miR-32-5p GNG4 0.130313603388223 0.177843055266148 -0.10801241280425 0.28331338760809 mirMAP -0.28496344709277 3.8176506885768e-11 NA NA NA hsa-miR-324-5p GNG4 0.0183370482495953 0.842996782677271 -0.10801241280425 0.28331338760809 miRanda -0.17772833694493 0.000106425272722788 NA NA NA hsa-miR-342-3p GNG4 -0.125683829770877 0.105810751640137 -0.10801241280425 0.28331338760809 mirMAP -0.256768548466673 1.76338019611017e-05 NA NA NA hsa-miR-3913-5p GNG4 0.276883251911602 0.00186113779811511 -0.10801241280425 0.28331338760809 mirMAP -0.253701623256843 4.21541529119562e-08 NA NA NA hsa-miR-452-5p GNG4 0.599327068454211 1.02031931068531e-05 -0.10801241280425 0.28331338760809 mirMAP -0.278131503324159 1.47154080757358e-21 NA NA NA hsa-miR-590-3p GNG4 0.312951515438396 0.000480455423843996 -0.10801241280425 0.28331338760809 miRanda;mirMAP -0.400189090907753 4.42671661112273e-19 NA NA NA hsa-miR-92b-3p GNG4 -0.213968504161963 0.0523921855715716 -0.10801241280425 0.28331338760809 mirMAP -0.368558767404576 4.74014015497471e-18 NA NA NA hsa-miR-183-5p GNG5 -0.122352002042746 0.484640364004636 0.50308602280951 1.62304022291004e-08 MirTarget;miRNATAP -0.135433429870383 3.55216011861587e-10 NA NA NA hsa-miR-130a-5p GNG7 0.155569168973665 0.0884246261384798 -0.0651612877109073 0.368794779724342 mirMAP -0.124661590400574 8.43949583131917e-05 NA NA NA hsa-miR-135a-5p GNG7 -0.122734612943241 0.196985964641886 -0.0651612877109073 0.368794779724342 miRNATAP -0.106279495315571 0.00062775509492372 NA NA NA hsa-miR-181a-2-3p GNG7 -0.0630409614874416 0.473088318215936 -0.0651612877109073 0.368794779724342 mirMAP -0.262707802337236 6.99930464398612e-09 NA NA NA hsa-miR-195-3p GNG7 0.100105455903079 0.133362389112338 -0.0651612877109073 0.368794779724342 miRNATAP -0.150249948488372 0.000664435947308588 NA NA NA hsa-miR-92a-3p GNG7 0.0407239381334659 0.643983393805961 -0.0651612877109073 0.368794779724342 miRNAWalker2_validate -0.166201096067161 0.00131568360363746 NA NA NA hsa-let-7a-2-3p GRIN1 0.295235553592458 0.00290654476250609 -1.21467178764683 3.37485471660921e-07 mirMAP -0.564938071493715 1.08215746648648e-07 NA NA NA hsa-miR-10a-5p GRIN1 1.10332501906319 5.3831631561183e-08 -1.21467178764683 3.37485471660921e-07 mirMAP -0.339766360147828 1.45332358266551e-11 NA NA NA hsa-miR-10b-5p GRIN1 1.54586540986745 2.64595843546465e-08 -1.21467178764683 3.37485471660921e-07 mirMAP -0.22018081010092 3.38532065207601e-09 NA NA NA hsa-miR-1262 GRIN1 0.276259331706731 0.0259799942226561 -1.21467178764683 3.37485471660921e-07 mirMAP -0.750969346531075 1.89484812737693e-19 NA NA NA hsa-miR-16-5p GRIN1 0.246024668671282 0.00346042804503716 -1.21467178764683 3.37485471660921e-07 mirMAP -0.444331835178375 0.00256929127137022 NA NA NA hsa-miR-217 GRIN1 0.540279882451941 0.00312206944061206 -1.21467178764683 3.37485471660921e-07 miRanda -0.350175168492301 5.25936013334713e-10 NA NA NA hsa-miR-296-5p GRIN1 -0.0192165981442809 0.870822664524408 -1.21467178764683 3.37485471660921e-07 mirMAP -0.331300129995291 0.000191715846667204 NA NA NA hsa-miR-30c-2-3p GRIN1 -0.18630560418806 0.0313113706136533 -1.21467178764683 3.37485471660921e-07 mirMAP -0.472151929637274 0.000348082107708141 NA NA NA hsa-miR-423-5p GRIN1 0.0965587900813789 0.148039180704338 -1.21467178764683 3.37485471660921e-07 miRNATAP -0.721028409468695 4.49127437045503e-05 NA NA NA hsa-miR-542-3p GRIN1 0.0835995677900829 0.403838744494071 -1.21467178764683 3.37485471660921e-07 miRanda -0.533555398856959 3.81558568351677e-06 NA NA NA hsa-miR-130b-5p GRIN2A 0.413070888963592 1.98866876365509e-06 -0.39664074618196 0.0368628530683379 mirMAP -0.384218710559465 8.9856621883567e-05 NA NA NA hsa-miR-182-5p GRIN2A -0.146726537592027 0.389265298808118 -0.39664074618196 0.0368628530683379 mirMAP -0.181799191752844 0.000357053044998502 NA NA NA hsa-miR-320a GRIN2A 0.092135599636725 0.243028758989929 -0.39664074618196 0.0368628530683379 PITA -0.371663846975334 0.00477935122036169 NA NA NA hsa-miR-17-5p GRIN2B 0.0975751369167082 0.20621110214601 -0.461617306952617 0.0217770530921861 TargetScan -0.464495180947078 0.00105886072293806 NA NA NA hsa-miR-590-5p GRIN2B 0.16946027035949 0.0386004382081678 -0.461617306952617 0.0217770530921861 miRanda -0.317540729098277 0.00357479004807434 NA NA NA hsa-let-7b-5p HRAS 0.036218385218298 0.719557004564478 -0.0696529935819452 0.235865730348535 miRTarBase -0.105421362575589 0.000967581673758039 20607356;20881268;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;On the basis of these data we suggest that the downregulation of let-7b and let-7e targeting K-ras and the upregulation of miR-17* a CRC marker could be considered as candidate molecular markers of cetuximab resistance;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;drug resistance;;;progression glioblastoma;colorectal cancer;lung cancer;lung cancer;pancreatic cancer hsa-miR-181d-5p HRAS -0.0746131973223108 0.331281641674538 -0.0696529935819452 0.235865730348535 miRNAWalker2_validate;miRTarBase -0.133860130747548 5.02157599075857e-05 NA NA NA hsa-miR-320a IGF1 0.092135599636725 0.243028758989929 -0.203195580339987 0.029670632911231 miRNATAP -0.272065311188534 2.24035754570114e-05 NA NA NA hsa-miR-592 IGF1 0.0170005651576508 0.876633091134809 -0.203195580339987 0.029670632911231 mirMAP -0.113833175952146 0.00219422982453576 NA NA NA hsa-miR-9-3p IGF1 -0.184945845984695 0.0290051908009009 -0.203195580339987 0.029670632911231 MirTarget -0.387265166384702 1.83580721842057e-09 NA NA NA hsa-let-7a-2-3p IGF1R 0.295235553592458 0.00290654476250609 -0.135857700792996 0.0366015528395905 MirTarget -0.111844113337644 4.71752976588472e-06 NA NA NA hsa-let-7d-5p IGF1R 0.111345229817909 0.0872634398336815 -0.135857700792996 0.0366015528395905 miRNAWalker2_validate;MirTarget;miRNATAP -0.141496888931225 0.00201553181843325 25287248 Focusing on the let-7d-5p/3p pair the respectively targeted IGF1R and KRAS were shown to be in a reverse relationship with expression of the respective miRNA which was confirmed in transient transfection assays using let-7d mimic or inhibitor; Targeting of KRAS by let-7d was previous reported; targeting of IGF1R by let-7d-5p was confirmed in luciferase assays in this study colon cancer hsa-let-7e-5p IGF1R 0.0471189209570344 0.657255455444655 -0.135857700792996 0.0366015528395905 miRNAWalker2_validate;MirTarget;miRNATAP -0.114160905645784 1.70469221142321e-05 NA NA NA hsa-let-7i-5p IGF1R 0.0952853587923244 0.192120688957249 -0.135857700792996 0.0366015528395905 MirTarget;miRNATAP -0.143251608697034 0.000624830602176317 NA NA NA hsa-miR-100-5p IGF1R 0.0939087252225708 0.437623927320764 -0.135857700792996 0.0366015528395905 miRNAWalker2_validate;miRTarBase;miRNATAP -0.111976354725609 3.28018438141415e-06 26306402 MiR 100 Inhibits Osteosarcoma Cell Proliferation Migration and Invasion and Enhances Chemosensitivity by Targeting IGFIR sarcoma hsa-miR-1226-3p IGF1R -0.098618802853881 0.346683714981524 -0.135857700792996 0.0366015528395905 miRNAWalker2_validate -0.121153312818867 1.08191177748407e-07 NA NA NA hsa-miR-125a-5p IGF1R -0.0833349424517387 0.325440200253607 -0.135857700792996 0.0366015528395905 mirMAP -0.147556188755988 2.29881742294783e-05 NA NA NA hsa-miR-146b-5p IGF1R 0.441078059667297 0.000237619929889385 -0.135857700792996 0.0366015528395905 miRanda -0.187507715140224 1.74252880158923e-20 NA NA NA hsa-miR-150-5p IGF1R 0.0645271721519611 0.513295658828718 -0.135857700792996 0.0366015528395905 mirMAP -0.113574958431 6.39127271912064e-06 NA NA NA hsa-miR-155-5p IGF1R 0.969837380981085 5.86551495710056e-15 -0.135857700792996 0.0366015528395905 mirMAP -0.179979563546528 2.15898058291216e-23 NA NA NA hsa-miR-15a-5p IGF1R 0.142658985373611 0.0536219185009004 -0.135857700792996 0.0366015528395905 miRNATAP -0.220577661461589 1.44916039393184e-08 NA NA NA hsa-miR-15b-3p IGF1R 0.690804403863844 8.48784755123775e-09 -0.135857700792996 0.0366015528395905 mirMAP -0.111463102273951 9.95387622335059e-09 NA NA NA hsa-miR-15b-5p IGF1R 0.592863156692837 1.41971517354055e-10 -0.135857700792996 0.0366015528395905 miRNATAP -0.173396273506064 1.10991318492391e-10 NA NA NA hsa-miR-16-1-3p IGF1R 0.346674816118499 1.86447850167636e-05 -0.135857700792996 0.0366015528395905 mirMAP -0.12478499182804 2.66303693915625e-05 NA NA NA hsa-miR-16-5p IGF1R 0.246024668671282 0.00346042804503716 -0.135857700792996 0.0366015528395905 miRNATAP -0.11321519810342 0.000784203747074522 23507142 Furthermore we confirmed that IGF1R is a direct target of miR-16; In clinical specimens IGF1R levels inversely correlate with miR-16 expression; Our results provide significant clues regarding the role of miR-16 as a tumor suppressor by targeting IGF1R in OS sarcoma hsa-miR-185-5p IGF1R -0.0767432095218297 0.404113540276816 -0.135857700792996 0.0366015528395905 MirTarget -0.141974511693695 2.19850793343084e-07 NA NA NA hsa-miR-186-5p IGF1R 0.0606381894130505 0.514217717592464 -0.135857700792996 0.0366015528395905 mirMAP -0.135875158869578 1.62131352659683e-06 NA NA NA hsa-miR-193a-5p IGF1R 0.183172152450491 0.0749251910521214 -0.135857700792996 0.0366015528395905 mirMAP -0.160873095360192 1.10303591982986e-11 NA NA NA hsa-miR-204-5p IGF1R -0.288588537398065 0.113371226435822 -0.135857700792996 0.0366015528395905 mirMAP -0.105120791209469 3.07608780592501e-16 NA NA NA hsa-miR-22-5p IGF1R 0.0437233965539527 0.639996108995995 -0.135857700792996 0.0366015528395905 miRNATAP -0.233612891233152 1.67343345024034e-20 NA NA NA hsa-miR-223-3p IGF1R -0.0272428307560952 0.814395950305568 -0.135857700792996 0.0366015528395905 miRNAWalker2_validate;miRTarBase;MirTarget -0.105624460737198 6.62170883444042e-07 NA NA NA hsa-miR-27a-3p IGF1R 0.303760032895792 0.00457375391189806 -0.135857700792996 0.0366015528395905 mirMAP -0.12913454459956 7.6944208648304e-08 NA NA NA hsa-miR-27b-3p IGF1R -0.0599187745243146 0.58208143475992 -0.135857700792996 0.0366015528395905 mirMAP -0.130230285662681 7.21485706769308e-08 NA NA NA hsa-miR-28-3p IGF1R 0.139444423971018 0.0811187936164314 -0.135857700792996 0.0366015528395905 miRNATAP -0.219347950616091 1.27643146821018e-08 NA NA NA hsa-miR-29b-1-5p IGF1R 0.191335428755774 0.00846436454790702 -0.135857700792996 0.0366015528395905 mirMAP -0.101621751277851 0.00209474462853739 NA NA NA hsa-miR-29b-2-5p IGF1R -0.26834261955727 0.00453760540520233 -0.135857700792996 0.0366015528395905 mirMAP -0.11968024513945 3.4175624103053e-06 NA NA NA hsa-miR-29b-3p IGF1R -0.178522712044497 0.0856106432165465 -0.135857700792996 0.0366015528395905 mirMAP -0.114732262376249 8.64287684380274e-06 NA NA NA hsa-miR-30a-5p IGF1R -0.062942936611238 0.513851954700252 -0.135857700792996 0.0366015528395905 miRNAWalker2_validate;mirMAP;miRNATAP -0.321413980606243 1.22679278357007e-15 26025408 MiR 30a suppresses non small cell lung cancer progression through AKT signaling pathway by targeting IGF1R progression lung squamous cell cancer hsa-miR-30c-5p IGF1R -0.0469114469943097 0.565934557464627 -0.135857700792996 0.0366015528395905 mirMAP;miRNATAP -0.230002465858637 8.18731367001754e-10 NA NA NA hsa-miR-30e-5p IGF1R 0.0764521828640934 0.41904991629622 -0.135857700792996 0.0366015528395905 mirMAP -0.143540390056724 5.82029246607952e-05 NA NA NA hsa-miR-335-3p IGF1R 0.34540584335595 0.00043848660222294 -0.135857700792996 0.0366015528395905 MirTarget;mirMAP -0.136751359128133 4.97175707442735e-08 NA NA NA hsa-miR-339-5p IGF1R 0.273253751377152 0.0185300170790638 -0.135857700792996 0.0366015528395905 miRanda -0.153962339964182 2.74692838301299e-14 NA NA NA hsa-miR-342-3p IGF1R -0.125683829770877 0.105810751640137 -0.135857700792996 0.0366015528395905 mirMAP -0.118476444643386 0.000633663719734603 NA NA NA hsa-miR-342-5p IGF1R 0.0383784541944436 0.544128449296127 -0.135857700792996 0.0366015528395905 mirMAP -0.112524201976166 0.00391139689026399 NA NA NA hsa-miR-34a-5p IGF1R 0.143472919835524 0.211283228567057 -0.135857700792996 0.0366015528395905 miRNAWalker2_validate -0.191685104791376 2.10748904516836e-20 NA NA NA hsa-miR-3613-5p IGF1R 0.290347525750076 0.000408393430033494 -0.135857700792996 0.0366015528395905 mirMAP;miRNATAP -0.10521570098555 0.000356259921566232 NA NA NA hsa-miR-365a-3p IGF1R -0.184222766207919 0.0292663235724171 -0.135857700792996 0.0366015528395905 MirTarget -0.171741101211553 2.51856138923681e-09 NA NA NA hsa-miR-3677-3p IGF1R 0.527366765774056 8.67571839358047e-06 -0.135857700792996 0.0366015528395905 MirTarget -0.103538913576777 1.77620312145945e-07 NA NA NA hsa-miR-374a-5p IGF1R 0.0121037060909277 0.865417963345881 -0.135857700792996 0.0366015528395905 mirMAP -0.105064579623646 0.00384548098849303 NA NA NA hsa-miR-455-5p IGF1R 0.332224239762 0.0106491358056238 -0.135857700792996 0.0366015528395905 miRNATAP -0.103928020876914 1.28483539149689e-08 NA NA NA hsa-miR-484 IGF1R -0.0190828819137732 0.802298900989652 -0.135857700792996 0.0366015528395905 miRNAWalker2_validate -0.179299177213309 9.20541708643153e-08 NA NA NA hsa-miR-500a-3p IGF1R 0.0479457078972052 0.49420307623914 -0.135857700792996 0.0366015528395905 mirMAP -0.262497002716637 3.76506049763252e-11 NA NA NA hsa-miR-532-5p IGF1R 0.0263466708637097 0.75763006039876 -0.135857700792996 0.0366015528395905 miRNATAP -0.125250941892347 0.000262963601498015 NA NA NA hsa-miR-664a-5p IGF1R 0.0825994937558296 0.264421724444089 -0.135857700792996 0.0366015528395905 mirMAP -0.11257452285757 0.000545736921772279 NA NA NA hsa-miR-671-5p IGF1R 0.379677704170736 0.000129391032677459 -0.135857700792996 0.0366015528395905 mirMAP -0.212486325599271 4.65998192495444e-20 NA NA NA hsa-miR-877-5p IGF1R -0.0775421790642756 0.423413623033696 -0.135857700792996 0.0366015528395905 MirTarget -0.13665782646676 2.66229946061684e-08 NA NA NA hsa-miR-98-5p IGF1R -0.0806971683871618 0.251777941211683 -0.135857700792996 0.0366015528395905 MirTarget -0.151288810093955 9.06306112934266e-05 NA NA NA hsa-miR-99b-5p IGF1R 0.0938366784257259 0.419406306408393 -0.135857700792996 0.0366015528395905 miRNATAP -0.173663460909332 7.58885489256862e-11 22425712 Furthermore ectopic transfection of miR-99 family members down-regulated the expression of insulin-like growth factor 1 receptor IGF1R and mechanistic target of rapamycin mTOR genes; The deregulation of miR-99 family contributes to the tumorigenesis of HNSCC in part by targeting IGF1R and mTOR signaling pathways tumorigenesis head and neck cancer hsa-miR-767-5p IGF2 -0.551653504513145 2.61109058244854e-05 0.547749272917527 5.56068746919415e-05 mirMAP -0.138842543332253 0.00240851695785419 NA NA NA hsa-miR-9-5p IGF2 -0.125377971246422 0.269896477802284 0.547749272917527 5.56068746919415e-05 mirMAP -0.764136496575201 2.64899610699679e-09 NA NA NA hsa-miR-139-5p IKBKB -0.647754756897633 2.15378307237163e-06 0.113293458902771 0.0150457519384782 miRanda -0.130032749382716 1.65206176469125e-33 NA NA NA hsa-miR-491-5p IKBKB -0.749881113074983 8.22859263179194e-09 0.113293458902771 0.0150457519384782 miRanda -0.106383336993955 5.8305133961577e-22 NA NA NA hsa-miR-149-5p KDR -0.0535821592029952 0.657713892012548 0.270090175645727 0.00117141833672443 miRNATAP -0.139518259926423 2.03714324877248e-06 NA NA NA hsa-miR-3065-3p KDR -0.261348288537884 0.0343753235107924 0.270090175645727 0.00117141833672443 miRNATAP -0.177937727091403 1.20271139230931e-09 NA NA NA hsa-let-7a-3p KIT 0.0530563276543763 0.370749834463566 -0.261513444505928 0.0224276861944585 mirMAP -0.262331289304824 0.00525211131719426 NA NA NA hsa-miR-130a-3p KIT 0.163798739071237 0.031259491216363 -0.261513444505928 0.0224276861944585 miRNATAP -0.231855422043864 0.00150277906755264 NA NA NA hsa-miR-130b-3p KIT 0.503911467685709 9.46590588950823e-08 -0.261513444505928 0.0224276861944585 miRNATAP -0.216937004051 4.59739848770853e-05 NA NA NA hsa-miR-186-5p KIT 0.0606381894130505 0.514217717592464 -0.261513444505928 0.0224276861944585 miRNAWalker2_validate -0.34743038777356 2.40438478065183e-09 NA NA NA hsa-miR-19a-3p KIT 0.0466707843731911 0.576818938277755 -0.261513444505928 0.0224276861944585 miRTarBase;miRNATAP -0.257936426733777 3.21641658437679e-05 NA NA NA hsa-miR-19b-3p KIT -0.0138427450847924 0.856506310673067 -0.261513444505928 0.0224276861944585 miRNATAP -0.279868403634775 0.000157171592661387 NA NA NA hsa-miR-20a-5p KIT -0.0115865752288853 0.887069448776018 -0.261513444505928 0.0224276861944585 miRTarBase -0.265184760437514 0.000286322485800346 NA NA NA hsa-miR-301a-3p KIT 0.00956875714542704 0.916380325220259 -0.261513444505928 0.0224276861944585 miRNATAP -0.342457770729474 1.18002595552452e-09 NA NA NA hsa-miR-3065-5p KIT -0.262608140481507 0.0414570974148034 -0.261513444505928 0.0224276861944585 miRNATAP -0.198440173399371 2.2912016162194e-07 NA NA NA hsa-miR-454-3p KIT 0.177318549827649 0.0120865170334418 -0.261513444505928 0.0224276861944585 miRNATAP -0.427120755320098 3.91470847817685e-09 NA NA NA hsa-miR-505-3p KIT 0.115486008167472 0.109833720698312 -0.261513444505928 0.0224276861944585 MirTarget;miRNATAP -0.249282789198895 0.000599642666303086 NA NA NA hsa-miR-590-3p KIT 0.312951515438396 0.000480455423843996 -0.261513444505928 0.0224276861944585 miRanda;mirMAP -0.248407335841872 6.45963700993833e-06 NA NA NA hsa-miR-130a-5p KITLG 0.155569168973665 0.0884246261384798 -0.132761163427261 0.141337162287193 mirMAP -0.13758996984404 0.00137158076152604 NA NA NA hsa-miR-17-3p KITLG 0.0217768908350733 0.801140991374649 -0.132761163427261 0.141337162287193 MirTarget -0.220462361422951 1.62122664143473e-05 NA NA NA hsa-miR-186-5p KITLG 0.0606381894130505 0.514217717592464 -0.132761163427261 0.141337162287193 mirMAP -0.121734823324206 0.00804371048343725 NA NA NA hsa-miR-19a-3p KITLG 0.0466707843731911 0.576818938277755 -0.132761163427261 0.141337162287193 mirMAP -0.244554775973164 3.67870042951592e-07 NA NA NA hsa-miR-19b-3p KITLG -0.0138427450847924 0.856506310673067 -0.132761163427261 0.141337162287193 mirMAP -0.344866032075577 1.47814962130317e-09 NA NA NA hsa-miR-450b-5p KITLG 0.270544879013992 0.00801537838499562 -0.132761163427261 0.141337162287193 MirTarget;PITA;mirMAP -0.191852673840172 5.00570483315268e-07 NA NA NA hsa-miR-9-3p KITLG -0.184945845984695 0.0290051908009009 -0.132761163427261 0.141337162287193 MirTarget -0.265584919065147 1.74791205012059e-05 NA NA NA hsa-let-7a-3p KRAS 0.0530563276543763 0.370749834463566 -0.0976184278638819 0.0473238165779176 mirMAP;miRNATAP -0.163441029301714 2.66738583745088e-07 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-miR-30b-5p KRAS -0.0858101016322106 0.263243418521854 -0.0976184278638819 0.0473238165779176 mirMAP;miRNATAP -0.131312331179891 6.91058885171462e-07 NA NA NA hsa-miR-125a-5p KSR1 -0.0833349424517387 0.325440200253607 -0.170855330652622 0.00115397929584054 miRanda;mirMAP -0.139366859468344 1.78474410505882e-07 NA NA NA hsa-miR-150-5p KSR1 0.0645271721519611 0.513295658828718 -0.170855330652622 0.00115397929584054 mirMAP -0.102137323196294 1.19445155583775e-07 NA NA NA hsa-miR-200c-3p KSR1 0.413752622631695 8.6936333715621e-06 -0.170855330652622 0.00115397929584054 mirMAP -0.166147969082144 5.11722955105268e-18 NA NA NA hsa-miR-28-5p KSR1 0.104003572105781 0.153594705579534 -0.170855330652622 0.00115397929584054 miRanda -0.128125671920424 2.46132071751521e-06 NA NA NA hsa-miR-30a-5p KSR1 -0.062942936611238 0.513851954700252 -0.170855330652622 0.00115397929584054 MirTarget -0.208188300731415 2.46656173286347e-11 NA NA NA hsa-miR-30c-5p KSR1 -0.0469114469943097 0.565934557464627 -0.170855330652622 0.00115397929584054 MirTarget -0.154280436647221 9.77750787842921e-08 NA NA NA hsa-miR-30d-5p KSR1 -0.0607010868720046 0.471410043548794 -0.170855330652622 0.00115397929584054 MirTarget -0.128457447940208 0.000109600504620696 NA NA NA hsa-miR-30e-5p KSR1 0.0764521828640934 0.41904991629622 -0.170855330652622 0.00115397929584054 MirTarget -0.188123062438585 3.57885097754622e-12 NA NA NA hsa-miR-320c KSR1 0.343259124189966 0.000248338401291051 -0.170855330652622 0.00115397929584054 miRanda;mirMAP -0.110810756113113 3.29309919450367e-08 NA NA NA hsa-miR-361-3p KSR1 -0.0798653643614555 0.271064714084553 -0.170855330652622 0.00115397929584054 mirMAP -0.15960616091774 3.49482653647992e-08 NA NA NA hsa-miR-532-5p KSR1 0.0263466708637097 0.75763006039876 -0.170855330652622 0.00115397929584054 mirMAP -0.122240423559879 3.36022673814469e-06 NA NA NA hsa-miR-590-3p KSR1 0.312951515438396 0.000480455423843996 -0.170855330652622 0.00115397929584054 mirMAP -0.118386478176965 6.15076812850045e-09 NA NA NA hsa-let-7a-2-3p KSR2 0.295235553592458 0.00290654476250609 -1.40515906446051 3.09034091577852e-15 mirMAP -0.44173457722355 4.65210543560022e-08 NA NA NA hsa-miR-106b-5p KSR2 0.167096183547615 0.0497544396383451 -1.40515906446051 3.09034091577852e-15 mirMAP -0.83790980246299 5.75109423101538e-16 NA NA NA hsa-miR-130a-5p KSR2 0.155569168973665 0.0884246261384798 -1.40515906446051 3.09034091577852e-15 mirMAP -0.337266449857069 0.000140602925275673 NA NA NA hsa-miR-130b-5p KSR2 0.413070888963592 1.98866876365509e-06 -1.40515906446051 3.09034091577852e-15 mirMAP -0.639591970983133 6.02974299763167e-12 NA NA NA hsa-miR-141-3p KSR2 0.41120561991992 0.000393344390969055 -1.40515906446051 3.09034091577852e-15 mirMAP -0.409960820242433 2.94336415592897e-09 NA NA NA hsa-miR-142-5p KSR2 0.434884875454107 0.000575570345702788 -1.40515906446051 3.09034091577852e-15 mirMAP -0.436760997391236 1.29870224127493e-12 NA NA NA hsa-miR-148a-3p KSR2 0.306821592493439 0.0392356958885949 -1.40515906446051 3.09034091577852e-15 mirMAP -0.343398484223128 7.35680146943591e-10 NA NA NA hsa-miR-148b-3p KSR2 0.0710353380371513 0.322794068460232 -1.40515906446051 3.09034091577852e-15 mirMAP -0.360653679014144 0.00496786917655105 NA NA NA hsa-miR-148b-5p KSR2 0.127111784487801 0.188731110216917 -1.40515906446051 3.09034091577852e-15 mirMAP -0.359220030780188 1.65406524038758e-05 NA NA NA hsa-miR-155-5p KSR2 0.969837380981085 5.86551495710056e-15 -1.40515906446051 3.09034091577852e-15 mirMAP -0.723918419279996 4.04436009524248e-35 NA NA NA hsa-miR-17-5p KSR2 0.0975751369167082 0.20621110214601 -1.40515906446051 3.09034091577852e-15 mirMAP -0.683065922929142 8.0320974793363e-08 NA NA NA hsa-miR-186-5p KSR2 0.0606381894130505 0.514217717592464 -1.40515906446051 3.09034091577852e-15 mirMAP -0.56562600832399 1.46946593150405e-09 NA NA NA hsa-miR-196b-5p KSR2 1.75082572326205 4.54452311288514e-11 -1.40515906446051 3.09034091577852e-15 mirMAP -0.368650592900248 2.76160390597248e-40 NA NA NA hsa-miR-199a-3p KSR2 0.41226331871076 0.000497136154474528 -1.40515906446051 3.09034091577852e-15 mirMAP -0.381071204790942 1.67827866955628e-08 NA NA NA hsa-miR-199a-5p KSR2 0.174889610847968 0.0900027418912454 -1.40515906446051 3.09034091577852e-15 mirMAP -0.250707819212629 0.00138686750290021 NA NA NA hsa-miR-199b-3p KSR2 0.411848361704393 0.000517815011892379 -1.40515906446051 3.09034091577852e-15 mirMAP -0.379391853228595 1.80450648674718e-08 NA NA NA hsa-miR-199b-5p KSR2 0.436298593972862 0.00200225454383871 -1.40515906446051 3.09034091577852e-15 mirMAP -0.376081185426425 9.58481231238701e-12 NA NA NA hsa-miR-20a-5p KSR2 -0.0115865752288853 0.887069448776018 -1.40515906446051 3.09034091577852e-15 mirMAP -0.312920668706491 0.00792151960366968 NA NA NA hsa-miR-21-5p KSR2 1.0504925175311 2.58081295984106e-11 -1.40515906446051 3.09034091577852e-15 mirMAP -0.778186125155932 1.19398343897934e-51 NA NA NA hsa-miR-22-5p KSR2 0.0437233965539527 0.639996108995995 -1.40515906446051 3.09034091577852e-15 mirMAP -0.229541499375659 0.00817849840483695 NA NA NA hsa-miR-223-3p KSR2 -0.0272428307560952 0.814395950305568 -1.40515906446051 3.09034091577852e-15 mirMAP -0.190762360540825 0.00735158237567611 NA NA NA hsa-miR-23a-3p KSR2 0.334693010651106 0.00144448147063433 -1.40515906446051 3.09034091577852e-15 mirMAP -0.77050012054075 2.61497798816757e-20 NA NA NA hsa-miR-25-3p KSR2 0.316649850160985 0.000777982468387578 -1.40515906446051 3.09034091577852e-15 miRNATAP -0.92434002086918 8.1152706887648e-18 NA NA NA hsa-miR-26a-2-3p KSR2 0.26597501648608 0.000796444054340143 -1.40515906446051 3.09034091577852e-15 mirMAP -0.653956623400985 4.0720188542203e-11 NA NA NA hsa-miR-27b-5p KSR2 0.224282840351546 0.00630787296051719 -1.40515906446051 3.09034091577852e-15 mirMAP -0.543643448583115 1.75474193464998e-08 NA NA NA hsa-miR-30c-5p KSR2 -0.0469114469943097 0.565934557464627 -1.40515906446051 3.09034091577852e-15 mirMAP -0.343955372689866 0.00643223926360626 NA NA NA hsa-miR-30e-5p KSR2 0.0764521828640934 0.41904991629622 -1.40515906446051 3.09034091577852e-15 mirMAP -0.462491393245056 9.74542768734912e-05 NA NA NA hsa-miR-32-5p KSR2 0.130313603388223 0.177843055266148 -1.40515906446051 3.09034091577852e-15 miRNATAP -0.417727179982062 5.63165131948034e-07 NA NA NA hsa-miR-320a KSR2 0.092135599636725 0.243028758989929 -1.40515906446051 3.09034091577852e-15 mirMAP -0.466462491519178 0.000224020948353785 NA NA NA hsa-miR-320c KSR2 0.343259124189966 0.000248338401291051 -1.40515906446051 3.09034091577852e-15 mirMAP -0.492833004812373 1.22885796264579e-08 NA NA NA hsa-miR-337-3p KSR2 0.117985828329978 0.346392018956732 -1.40515906446051 3.09034091577852e-15 mirMAP -0.182197099716622 0.00434744039340576 NA NA NA hsa-miR-374a-3p KSR2 0.176226170437625 0.0343958848425446 -1.40515906446051 3.09034091577852e-15 mirMAP -0.841105757620584 7.50456121319587e-13 NA NA NA hsa-miR-423-5p KSR2 0.0965587900813789 0.148039180704338 -1.40515906446051 3.09034091577852e-15 mirMAP -0.872948050104754 4.83187931604003e-11 NA NA NA hsa-miR-450b-5p KSR2 0.270544879013992 0.00801537838499562 -1.40515906446051 3.09034091577852e-15 mirMAP -0.497520128323896 2.05031319197309e-10 NA NA NA hsa-miR-452-5p KSR2 0.599327068454211 1.02031931068531e-05 -1.40515906446051 3.09034091577852e-15 mirMAP -0.555485771445219 2.30419004306648e-23 NA NA NA hsa-miR-455-5p KSR2 0.332224239762 0.0106491358056238 -1.40515906446051 3.09034091577852e-15 mirMAP -0.419903477093252 3.15721671444116e-12 NA NA NA hsa-miR-500a-3p KSR2 0.0479457078972052 0.49420307623914 -1.40515906446051 3.09034091577852e-15 mirMAP -0.396466131858614 0.00310680841923888 NA NA NA hsa-miR-505-3p KSR2 0.115486008167472 0.109833720698312 -1.40515906446051 3.09034091577852e-15 mirMAP -0.768003131980811 2.3686702542154e-11 NA NA NA hsa-miR-505-5p KSR2 0.0973008785018434 0.183209581426791 -1.40515906446051 3.09034091577852e-15 mirMAP -0.507845402537151 4.0704926052388e-06 NA NA NA hsa-miR-548b-3p KSR2 0.340474544210108 0.00224491592019745 -1.40515906446051 3.09034091577852e-15 mirMAP -0.452461327366951 2.37103467397637e-10 NA NA NA hsa-miR-550a-3p KSR2 0.311518294008363 0.0015285640451888 -1.40515906446051 3.09034091577852e-15 mirMAP -0.535039016518722 1.84830550031769e-11 NA NA NA hsa-miR-589-5p KSR2 -0.0382528919634639 0.5844074434222 -1.40515906446051 3.09034091577852e-15 mirMAP -0.438821247982325 0.000955899375436319 NA NA NA hsa-miR-590-3p KSR2 0.312951515438396 0.000480455423843996 -1.40515906446051 3.09034091577852e-15 mirMAP -0.739305563185132 1.09504162158601e-17 NA NA NA hsa-miR-590-5p KSR2 0.16946027035949 0.0386004382081678 -1.40515906446051 3.09034091577852e-15 mirMAP -0.626154684253316 1.13160380069218e-10 NA NA NA hsa-miR-629-3p KSR2 0.318874955109265 0.00062631284800046 -1.40515906446051 3.09034091577852e-15 mirMAP -0.508890317995681 1.84687427566806e-09 NA NA NA hsa-miR-629-5p KSR2 0.100422082714475 0.214291160007531 -1.40515906446051 3.09034091577852e-15 mirMAP -0.680669632838704 1.2554458702683e-10 NA NA NA hsa-miR-877-5p KSR2 -0.0775421790642756 0.423413623033696 -1.40515906446051 3.09034091577852e-15 mirMAP -0.214817493896958 0.00927465071086035 NA NA NA hsa-miR-92a-3p KSR2 0.0407239381334659 0.643983393805961 -1.40515906446051 3.09034091577852e-15 miRNATAP -0.605484739111337 2.60406486793263e-05 NA NA NA hsa-miR-99b-3p KSR2 0.0339709556778862 0.745836688043877 -1.40515906446051 3.09034091577852e-15 mirMAP -0.208909860332617 0.00819619512108657 NA NA NA hsa-let-7b-5p MAP2K2 0.036218385218298 0.719557004564478 0.0338816015099894 0.511977780289519 miRNAWalker2_validate -0.156288464298574 5.22052349984698e-12 NA NA NA hsa-let-7a-3p MAPK1 0.0530563276543763 0.370749834463566 -0.213353498035088 0.000389157534366882 mirMAP -0.101943093753909 0.00192343923976389 NA NA NA hsa-miR-15b-5p MAPK1 0.592863156692837 1.41971517354055e-10 -0.213353498035088 0.000389157534366882 miRNAWalker2_validate -0.146191950491781 3.61739654178022e-14 NA NA NA hsa-miR-17-5p MAPK1 0.0975751369167082 0.20621110214601 -0.213353498035088 0.000389157534366882 TargetScan -0.110084866776271 7.91694183424384e-05 NA NA NA hsa-miR-19a-3p MAPK1 0.0466707843731911 0.576818938277755 -0.213353498035088 0.000389157534366882 mirMAP -0.128018489349713 2.73892272625697e-09 NA NA NA hsa-miR-19b-3p MAPK1 -0.0138427450847924 0.856506310673067 -0.213353498035088 0.000389157534366882 mirMAP -0.176138435921289 5.03823623056019e-12 NA NA NA hsa-miR-320a MAPK1 0.092135599636725 0.243028758989929 -0.213353498035088 0.000389157534366882 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.152520075612356 2.3025642938828e-08 NA NA NA hsa-miR-454-3p MAPK1 0.177318549827649 0.0120865170334418 -0.213353498035088 0.000389157534366882 mirMAP -0.118488517070993 3.52065356643667e-06 NA NA NA hsa-miR-500a-3p MAPK1 0.0479457078972052 0.49420307623914 -0.213353498035088 0.000389157534366882 mirMAP -0.108343486711378 0.000199332911985672 NA NA NA hsa-miR-130a-3p MAPK10 0.163798739071237 0.031259491216363 -0.537388523547939 4.2393247633847e-14 miRNATAP -0.146227150931435 0.000409098979829322 NA NA NA hsa-miR-130b-3p MAPK10 0.503911467685709 9.46590588950823e-08 -0.537388523547939 4.2393247633847e-14 miRNATAP -0.240966176239797 3.00288673974579e-16 NA NA NA hsa-miR-19a-3p MAPK10 0.0466707843731911 0.576818938277755 -0.537388523547939 4.2393247633847e-14 miRNATAP -0.160174316971582 5.10852507077659e-06 NA NA NA hsa-miR-19b-3p MAPK10 -0.0138427450847924 0.856506310673067 -0.537388523547939 4.2393247633847e-14 miRNATAP -0.155216608611893 0.000219766758516242 NA NA NA hsa-miR-450b-5p MAPK10 0.270544879013992 0.00801537838499562 -0.537388523547939 4.2393247633847e-14 mirMAP -0.191975437167481 2.95244540267408e-12 NA NA NA hsa-miR-454-3p MAPK10 0.177318549827649 0.0120865170334418 -0.537388523547939 4.2393247633847e-14 miRNATAP -0.177198825931711 1.91997293458149e-05 NA NA NA hsa-miR-590-3p MAPK10 0.312951515438396 0.000480455423843996 -0.537388523547939 4.2393247633847e-14 miRanda;mirMAP -0.166335972989874 8.93923250001752e-08 NA NA NA hsa-miR-590-5p MAPK10 0.16946027035949 0.0386004382081678 -0.537388523547939 4.2393247633847e-14 PITA;miRanda;miRNATAP -0.145955971255782 2.52817190707301e-05 NA NA NA hsa-miR-320b MAPK3 0.283477746304177 0.0005953763020907 -0.216288134544279 3.58169845564714e-05 miRNAWalker2_validate -0.103417988183093 3.03681040754152e-07 NA NA NA hsa-miR-542-3p MAPK3 0.0835995677900829 0.403838744494071 -0.216288134544279 3.58169845564714e-05 miRanda -0.133723416342879 2.41125253328141e-13 NA NA NA hsa-miR-10a-5p MAPK8 1.10332501906319 5.3831631561183e-08 -0.302931149567583 0.000188583880708274 miRNAWalker2_validate -0.120186654516686 3.43413005950355e-13 NA NA NA hsa-miR-16-2-3p MAPK8 0.468816222075619 7.04377763166292e-05 -0.302931149567583 0.000188583880708274 mirMAP -0.102102855430457 0.000418952571359225 NA NA NA hsa-miR-22-5p MAPK8 0.0437233965539527 0.639996108995995 -0.302931149567583 0.000188583880708274 mirMAP -0.175094083929253 2.69922381021858e-06 NA NA NA hsa-miR-30a-5p MAPK8 -0.062942936611238 0.513851954700252 -0.302931149567583 0.000188583880708274 mirMAP -0.407693291423913 2.44429012802795e-12 NA NA NA hsa-miR-30b-5p MAPK8 -0.0858101016322106 0.263243418521854 -0.302931149567583 0.000188583880708274 mirMAP -0.161604562972212 0.00297088085323934 NA NA NA hsa-miR-30c-5p MAPK8 -0.0469114469943097 0.565934557464627 -0.302931149567583 0.000188583880708274 mirMAP -0.352021480256678 5.75202015716757e-11 NA NA NA hsa-miR-374a-3p MAPK8 0.176226170437625 0.0343958848425446 -0.302931149567583 0.000188583880708274 mirMAP -0.233850674687013 5.69445641069691e-06 NA NA NA hsa-miR-590-3p MAPK8 0.312951515438396 0.000480455423843996 -0.302931149567583 0.000188583880708274 miRNATAP -0.178854419631098 3.01021919217562e-06 NA NA NA hsa-let-7i-5p MAPK9 0.0952853587923244 0.192120688957249 -0.250992535130042 2.41271995485752e-05 miRNATAP -0.111926815056819 0.00309462880153316 NA NA NA hsa-miR-106b-5p MAPK9 0.167096183547615 0.0497544396383451 -0.250992535130042 2.41271995485752e-05 miRNAWalker2_validate;miRNATAP -0.10590505262462 0.000236784602878243 NA NA NA hsa-miR-320a MAPK9 0.092135599636725 0.243028758989929 -0.250992535130042 2.41271995485752e-05 miRanda;miRNATAP -0.209587243417478 6.52556108505869e-10 NA NA NA hsa-miR-320b MAPK9 0.283477746304177 0.0005953763020907 -0.250992535130042 2.41271995485752e-05 miRanda;miRNATAP -0.150322035936768 6.40324029911169e-09 NA NA NA hsa-miR-320c MAPK9 0.343259124189966 0.000248338401291051 -0.250992535130042 2.41271995485752e-05 miRanda;miRNATAP -0.160739998379643 5.6021711014594e-12 NA NA NA hsa-miR-542-3p MAPK9 0.0835995677900829 0.403838744494071 -0.250992535130042 2.41271995485752e-05 miRanda -0.120047809070845 4.59691685311462e-07 NA NA NA hsa-miR-93-5p MAPK9 0.139766237971122 0.101057320076629 -0.250992535130042 2.41271995485752e-05 miRNAWalker2_validate;miRNATAP -0.21497342781919 3.19876665049407e-08 NA NA NA hsa-miR-130b-5p MRAS 0.413070888963592 1.98866876365509e-06 -0.233931717638168 0.000196961048861355 mirMAP -0.210777239663277 5.68474950478573e-16 NA NA NA hsa-miR-423-5p MRAS 0.0965587900813789 0.148039180704338 -0.233931717638168 0.000196961048861355 miRNATAP -0.138926888377593 0.000258546948619713 NA NA NA hsa-let-7e-5p NF1 0.0471189209570344 0.657255455444655 -0.208322949466337 0.0011458902274678 miRNAWalker2_validate -0.112240974253758 5.20664404957301e-06 NA NA NA hsa-miR-103a-3p NF1 -0.147443193527362 0.128400914654149 -0.208322949466337 0.0011458902274678 MirTarget -0.279787322386383 9.63924737420609e-14 NA NA NA hsa-miR-125a-3p NF1 0.183834985432376 0.106230647107917 -0.208322949466337 0.0011458902274678 MirTarget;PITA;miRanda;miRNATAP -0.108763335831917 3.06806718987825e-08 NA NA NA hsa-miR-141-3p NF1 0.41120561991992 0.000393344390969055 -0.208322949466337 0.0011458902274678 mirMAP -0.154842879400521 4.15540253992273e-16 NA NA NA hsa-miR-146b-5p NF1 0.441078059667297 0.000237619929889385 -0.208322949466337 0.0011458902274678 miRanda -0.206218820065857 4.97898551937265e-29 NA NA NA hsa-miR-15a-5p NF1 0.142658985373611 0.0536219185009004 -0.208322949466337 0.0011458902274678 MirTarget -0.212647271024111 3.89531848172501e-09 NA NA NA hsa-miR-15b-5p NF1 0.592863156692837 1.41971517354055e-10 -0.208322949466337 0.0011458902274678 MirTarget -0.223371519381971 7.38949095688687e-20 NA NA NA hsa-miR-193a-3p NF1 0.395602305834739 0.00182611787714301 -0.208322949466337 0.0011458902274678 miRanda -0.114270075994005 9.864531962287e-11 NA NA NA hsa-miR-199a-5p NF1 0.174889610847968 0.0900027418912454 -0.208322949466337 0.0011458902274678 miRanda -0.107628627600729 7.72476898005927e-07 NA NA NA hsa-miR-199b-5p NF1 0.436298593972862 0.00200225454383871 -0.208322949466337 0.0011458902274678 miRanda -0.12455880164847 3.78533947782799e-16 NA NA NA hsa-miR-27a-3p NF1 0.303760032895792 0.00457375391189806 -0.208322949466337 0.0011458902274678 MirTarget -0.119789628615369 8.04107318966667e-08 NA NA NA hsa-miR-28-5p NF1 0.104003572105781 0.153594705579534 -0.208322949466337 0.0011458902274678 miRanda -0.173631313285854 1.14205896241135e-07 NA NA NA hsa-miR-29b-1-5p NF1 0.191335428755774 0.00846436454790702 -0.208322949466337 0.0011458902274678 mirMAP -0.123133163680988 5.6831021352664e-05 NA NA NA hsa-miR-30a-5p NF1 -0.062942936611238 0.513851954700252 -0.208322949466337 0.0011458902274678 MirTarget;mirMAP;miRNATAP -0.22028884976692 5.87049235871482e-09 NA NA NA hsa-miR-30b-5p NF1 -0.0858101016322106 0.263243418521854 -0.208322949466337 0.0011458902274678 MirTarget;mirMAP -0.202204782886355 5.71701288641473e-09 NA NA NA hsa-miR-30c-5p NF1 -0.0469114469943097 0.565934557464627 -0.208322949466337 0.0011458902274678 MirTarget;mirMAP;miRNATAP -0.285158877990468 8.93342264409763e-17 NA NA NA hsa-miR-30e-5p NF1 0.0764521828640934 0.41904991629622 -0.208322949466337 0.0011458902274678 MirTarget;mirMAP -0.106353213765329 0.00138760965841904 NA NA NA hsa-miR-361-5p NF1 0.0107519600643302 0.882230614095565 -0.208322949466337 0.0011458902274678 miRanda -0.21203313018317 2.09196687287572e-08 NA NA NA hsa-miR-362-3p NF1 0.032375035235532 0.736465332563774 -0.208322949466337 0.0011458902274678 miRanda -0.101752829398611 1.106583550246e-05 NA NA NA hsa-miR-362-5p NF1 -0.0730185557229279 0.425572997292224 -0.208322949466337 0.0011458902274678 mirMAP -0.109449743347363 9.32353758054643e-06 NA NA NA hsa-miR-452-5p NF1 0.599327068454211 1.02031931068531e-05 -0.208322949466337 0.0011458902274678 MirTarget -0.110222398533347 5.2292740136393e-12 NA NA NA hsa-miR-455-5p NF1 0.332224239762 0.0106491358056238 -0.208322949466337 0.0011458902274678 miRanda -0.118083682156973 2.34344893963398e-12 NA NA NA hsa-miR-590-3p NF1 0.312951515438396 0.000480455423843996 -0.208322949466337 0.0011458902274678 MirTarget;PITA;miRanda;miRNATAP -0.16724229498015 7.78156222698355e-12 NA NA NA hsa-miR-590-5p NF1 0.16946027035949 0.0386004382081678 -0.208322949466337 0.0011458902274678 miRanda -0.115896038002145 2.43570759105084e-05 NA NA NA hsa-miR-1179 NFKB1 -0.117056451908751 0.310989525634765 0.146182859193676 0.0048570839713069 miRNATAP -0.140273206429428 5.35154124955416e-17 NA NA NA hsa-miR-508-3p NFKB1 -0.292045725850845 0.0158994578296519 0.146182859193676 0.0048570839713069 MirTarget;PITA;miRNATAP -0.101247627472892 1.16240035097528e-10 NA NA NA hsa-miR-9-5p NFKB1 -0.125377971246422 0.269896477802284 0.146182859193676 0.0048570839713069 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.336428914988368 4.98439106747222e-16 NA NA NA hsa-let-7c-5p NGF -0.04295851886768 0.676052842748691 -0.416457950464278 0.0030667540551424 MirTarget -0.360257350329555 1.22298479321338e-05 NA NA NA hsa-let-7e-5p NGF 0.0471189209570344 0.657255455444655 -0.416457950464278 0.0030667540551424 MirTarget -0.207654601525943 0.00237596292059546 NA NA NA hsa-let-7i-5p NGF 0.0952853587923244 0.192120688957249 -0.416457950464278 0.0030667540551424 MirTarget -0.412016019685442 0.000120893499183623 NA NA NA hsa-miR-217 NGF 0.540279882451941 0.00312206944061206 -0.416457950464278 0.0030667540551424 miRanda -0.106355636018351 0.00151830983295066 NA NA NA hsa-miR-320a NGF 0.092135599636725 0.243028758989929 -0.416457950464278 0.0030667540551424 miRanda -0.445535637234912 4.53615837617544e-06 NA NA NA hsa-miR-320b NGF 0.283477746304177 0.0005953763020907 -0.416457950464278 0.0030667540551424 miRanda -0.295144471999818 6.92199710987292e-05 NA NA NA hsa-miR-320c NGF 0.343259124189966 0.000248338401291051 -0.416457950464278 0.0030667540551424 miRanda -0.420643347773402 2.54365030935421e-10 NA NA NA hsa-miR-423-5p NGF 0.0965587900813789 0.148039180704338 -0.416457950464278 0.0030667540551424 MirTarget;miRNATAP -0.377352274624578 0.000280283896732406 NA NA NA hsa-miR-29a-3p NRAS -0.224140851576083 0.0349516103550236 0.166825456686155 0.00198701675555357 miRNATAP -0.113429370178798 7.18564270439906e-07 NA NA NA hsa-miR-29c-3p NRAS -0.372180390387259 0.00202634431973208 0.166825456686155 0.00198701675555357 miRNATAP -0.103186593831709 9.57910873311229e-10 NA NA NA hsa-miR-664a-3p NRAS 0.0413918462467198 0.611334357897022 0.166825456686155 0.00198701675555357 MirTarget -0.11306016643066 1.53334474091839e-06 NA NA NA hsa-miR-137 NTRK1 -0.924849266740909 1.546832202049e-06 0.207348057458216 0.0386791072527031 miRanda -0.117432442139169 1.38166281095279e-07 NA NA NA hsa-miR-1179 NTRK2 -0.117056451908751 0.310989525634765 -0.686181111372964 1.63868289231844e-08 mirMAP -0.117785076587188 0.00455990920871272 NA NA NA hsa-miR-125a-3p NTRK2 0.183834985432376 0.106230647107917 -0.686181111372964 1.63868289231844e-08 miRanda -0.117049049301132 0.00488026725384927 NA NA NA hsa-miR-126-5p NTRK2 0.177332403948664 0.0711675116243123 -0.686181111372964 1.63868289231844e-08 mirMAP -0.210559355701016 2.22333970399353e-05 NA NA NA hsa-miR-130b-3p NTRK2 0.503911467685709 9.46590588950823e-08 -0.686181111372964 1.63868289231844e-08 mirMAP -0.48198693041308 1.47745844823795e-23 NA NA NA hsa-miR-130b-5p NTRK2 0.413070888963592 1.98866876365509e-06 -0.686181111372964 1.63868289231844e-08 mirMAP -0.348405926099145 1.78702109563048e-10 NA NA NA hsa-miR-140-3p NTRK2 -0.123864258867705 0.14796686619449 -0.686181111372964 1.63868289231844e-08 PITA -0.197847075214346 0.00628433840688937 NA NA NA hsa-miR-140-5p NTRK2 0.065063507103468 0.380452509211773 -0.686181111372964 1.63868289231844e-08 miRanda -0.259527342352345 0.000145290714682029 NA NA NA hsa-miR-143-3p NTRK2 0.289829963197683 0.0420892105534401 -0.686181111372964 1.63868289231844e-08 mirMAP -0.185965853420384 4.47219518844906e-07 NA NA NA hsa-miR-145-3p NTRK2 0.110543172922298 0.294150620210019 -0.686181111372964 1.63868289231844e-08 mirMAP -0.20443079458531 3.43520671853098e-06 NA NA NA hsa-miR-146b-5p NTRK2 0.441078059667297 0.000237619929889385 -0.686181111372964 1.63868289231844e-08 PITA;miRanda -0.285774957078472 8.72386440944543e-13 NA NA NA hsa-miR-155-5p NTRK2 0.969837380981085 5.86551495710056e-15 -0.686181111372964 1.63868289231844e-08 mirMAP -0.311414873073455 1.77395270740727e-18 NA NA NA hsa-miR-15b-3p NTRK2 0.690804403863844 8.48784755123775e-09 -0.686181111372964 1.63868289231844e-08 mirMAP -0.275120345518809 2.07845831566898e-13 NA NA NA hsa-miR-17-3p NTRK2 0.0217768908350733 0.801140991374649 -0.686181111372964 1.63868289231844e-08 miRNATAP -0.267488399217568 1.51674456927697e-05 NA NA NA hsa-miR-181b-5p NTRK2 0.0260899284211646 0.768941836912518 -0.686181111372964 1.63868289231844e-08 mirMAP -0.275460361374369 2.69131478075794e-05 NA NA NA hsa-miR-200c-3p NTRK2 0.413752622631695 8.6936333715621e-06 -0.686181111372964 1.63868289231844e-08 miRNAWalker2_validate;miRTarBase -0.189312281448708 0.000151698853560443 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-21-5p NTRK2 1.0504925175311 2.58081295984106e-11 -0.686181111372964 1.63868289231844e-08 mirMAP -0.236108791238634 4.9068404718365e-13 NA NA NA hsa-miR-27b-5p NTRK2 0.224282840351546 0.00630787296051719 -0.686181111372964 1.63868289231844e-08 mirMAP -0.182354407883954 0.00140069809613523 NA NA NA hsa-miR-320a NTRK2 0.092135599636725 0.243028758989929 -0.686181111372964 1.63868289231844e-08 mirMAP -0.320169674390035 1.45235884491897e-05 NA NA NA hsa-miR-320b NTRK2 0.283477746304177 0.0005953763020907 -0.686181111372964 1.63868289231844e-08 mirMAP -0.297676719953335 1.05142976932486e-07 NA NA NA hsa-miR-335-3p NTRK2 0.34540584335595 0.00043848660222294 -0.686181111372964 1.63868289231844e-08 mirMAP -0.301664968205129 5.38168841975694e-10 NA NA NA hsa-miR-335-5p NTRK2 0.0938511632756978 0.336889056387694 -0.686181111372964 1.63868289231844e-08 miRNAWalker2_validate -0.142160869298563 0.00359656740597952 NA NA NA hsa-miR-339-5p NTRK2 0.273253751377152 0.0185300170790638 -0.686181111372964 1.63868289231844e-08 miRanda -0.145781932800226 0.000287943821956961 NA NA NA hsa-miR-361-5p NTRK2 0.0107519600643302 0.882230614095565 -0.686181111372964 1.63868289231844e-08 miRanda;mirMAP -0.29237397328415 0.000253896813933908 NA NA NA hsa-miR-376c-3p NTRK2 -0.0513360810290662 0.710610589791979 -0.686181111372964 1.63868289231844e-08 mirMAP -0.140327427013934 3.33516406165561e-05 NA NA NA hsa-miR-409-3p NTRK2 0.00456692516634361 0.974143243758506 -0.686181111372964 1.63868289231844e-08 mirMAP -0.110267529518122 0.000884459244523279 NA NA NA hsa-miR-452-5p NTRK2 0.599327068454211 1.02031931068531e-05 -0.686181111372964 1.63868289231844e-08 mirMAP -0.169844766254734 5.09543021020336e-07 NA NA NA hsa-miR-454-3p NTRK2 0.177318549827649 0.0120865170334418 -0.686181111372964 1.63868289231844e-08 mirMAP -0.20934244817509 0.00245368136356355 NA NA NA hsa-miR-501-5p NTRK2 0.0878951859817452 0.309663377222443 -0.686181111372964 1.63868289231844e-08 mirMAP -0.145000560300687 0.00765735539714478 NA NA NA hsa-miR-590-3p NTRK2 0.312951515438396 0.000480455423843996 -0.686181111372964 1.63868289231844e-08 PITA;miRanda;mirMAP -0.221156268667124 2.02480061352176e-05 NA NA NA hsa-miR-590-5p NTRK2 0.16946027035949 0.0386004382081678 -0.686181111372964 1.63868289231844e-08 miRanda;mirMAP -0.155176251936937 0.00726049632647802 NA NA NA hsa-miR-320a PAK1 0.092135599636725 0.243028758989929 -0.0861639821170765 0.472264496235081 miRNAWalker2_validate;PITA;miRanda -0.440070048455266 5.8461135519197e-08 NA NA NA hsa-miR-320b PAK1 0.283477746304177 0.0005953763020907 -0.0861639821170765 0.472264496235081 PITA;miRanda -0.18860603631333 0.00250151683223796 NA NA NA hsa-miR-320c PAK1 0.343259124189966 0.000248338401291051 -0.0861639821170765 0.472264496235081 PITA;miRanda -0.240520876595702 1.96303772722076e-05 NA NA NA hsa-miR-423-5p PAK1 0.0965587900813789 0.148039180704338 -0.0861639821170765 0.472264496235081 miRNAWalker2_validate -0.312154649877171 0.000338522441056953 NA NA NA hsa-miR-342-3p PAK2 -0.125683829770877 0.105810751640137 0.0709706465766624 0.173159070772672 MirTarget;PITA;miRanda -0.149333228316984 2.76257081493856e-12 NA NA NA hsa-miR-361-5p PAK2 0.0107519600643302 0.882230614095565 0.0709706465766624 0.173159070772672 mirMAP -0.160327396785592 2.93784847431797e-10 NA NA NA hsa-miR-425-5p PAK2 -0.0412837711174561 0.682284485592858 0.0709706465766624 0.173159070772672 MirTarget -0.115829234353775 8.12642545192366e-14 NA NA NA hsa-miR-500a-3p PAK2 0.0479457078972052 0.49420307623914 0.0709706465766624 0.173159070772672 miRNAWalker2_validate -0.124847364931628 6.67497779683746e-07 NA NA NA hsa-miR-7-1-3p PAK2 -0.0894475316162393 0.37322359785108 0.0709706465766624 0.173159070772672 MirTarget -0.141197841123289 2.45832364038912e-22 NA NA NA hsa-miR-769-3p PAK2 -0.287263649023213 0.018145224330845 0.0709706465766624 0.173159070772672 PITA;miRNATAP -0.118358970821312 1.94543113981314e-23 NA NA NA hsa-miR-125a-5p PAK3 -0.0833349424517387 0.325440200253607 -0.408005920079218 0.0151181786775607 miRanda -0.372237412600065 0.000513560019461773 NA NA NA hsa-miR-146b-5p PAK3 0.441078059667297 0.000237619929889385 -0.408005920079218 0.0151181786775607 miRanda -0.261795735267605 4.33382594367806e-05 NA NA NA hsa-miR-200b-3p PAK3 0.245768526504511 0.0580744465744737 -0.408005920079218 0.0151181786775607 TargetScan -0.307456862036749 8.25899735761306e-08 NA NA NA hsa-miR-217 PAK3 0.540279882451941 0.00312206944061206 -0.408005920079218 0.0151181786775607 miRanda -0.176955128716656 9.40874212160908e-06 NA NA NA hsa-miR-23a-3p PAK3 0.334693010651106 0.00144448147063433 -0.408005920079218 0.0151181786775607 MirTarget -0.485943872300068 6.7341246022062e-10 NA NA NA hsa-miR-320a PAK3 0.092135599636725 0.243028758989929 -0.408005920079218 0.0151181786775607 miRanda -0.451580493111383 0.000107273194424945 NA NA NA hsa-miR-320c PAK3 0.343259124189966 0.000248338401291051 -0.408005920079218 0.0151181786775607 miRanda -0.355840473716836 9.46674796600849e-06 NA NA NA hsa-miR-362-5p PAK3 -0.0730185557229279 0.425572997292224 -0.408005920079218 0.0151181786775607 TargetScan -0.399073989904836 9.2637393617834e-07 NA NA NA hsa-miR-423-5p PAK3 0.0965587900813789 0.148039180704338 -0.408005920079218 0.0151181786775607 miRNATAP -0.404021485335074 0.00116578432642703 NA NA NA hsa-miR-455-5p PAK3 0.332224239762 0.0106491358056238 -0.408005920079218 0.0151181786775607 miRanda -0.270951551958112 1.46807395624343e-06 NA NA NA hsa-miR-548b-3p PAK3 0.340474544210108 0.00224491592019745 -0.408005920079218 0.0151181786775607 miRNATAP -0.208844913917424 0.0017893065082996 NA NA NA hsa-miR-590-3p PAK3 0.312951515438396 0.000480455423843996 -0.408005920079218 0.0151181786775607 miRanda -0.512289232410206 2.4500002752322e-10 NA NA NA hsa-miR-590-5p PAK3 0.16946027035949 0.0386004382081678 -0.408005920079218 0.0151181786775607 miRanda -0.36435263623598 5.89577754475353e-05 NA NA NA hsa-miR-9-5p PAK4 -0.125377971246422 0.269896477802284 0.109067548763017 0.0456412729834888 miRNATAP -0.217649420293969 7.81370118687622e-07 NA NA NA hsa-miR-1262 PAK6 0.276259331706731 0.0259799942226561 -0.234837841307207 0.124549223852798 miRNATAP -0.210815553482777 0.000121075687956165 NA NA NA hsa-miR-9-5p PAK6 -0.125377971246422 0.269896477802284 -0.234837841307207 0.124549223852798 miRNATAP -0.605464179292532 3.56174315787872e-05 NA NA NA hsa-miR-3065-5p PDGFA -0.262608140481507 0.0414570974148034 0.490091510735296 1.12439737196867e-06 mirMAP -0.172968495924815 2.92745603338613e-07 NA NA NA hsa-miR-767-5p PDGFB -0.551653504513145 2.61109058244854e-05 0.264702010292632 0.000199580243175127 PITA;miRNATAP -0.139160724595735 2.76800071159541e-10 NA NA NA hsa-let-7f-1-3p PDGFC 0.110713086694053 0.21484524300518 -0.109641054681205 0.135071652654198 mirMAP -0.148071279655735 6.42277243999981e-06 NA NA NA hsa-miR-124-3p PDGFC -0.506026514549291 0.0078056370358648 -0.109641054681205 0.135071652654198 miRNAWalker2_validate -0.130716324407655 4.05635206169265e-18 NA NA NA hsa-miR-16-2-3p PDGFC 0.468816222075619 7.04377763166292e-05 -0.109641054681205 0.135071652654198 mirMAP -0.111453310676802 5.82412948921634e-06 NA NA NA hsa-miR-326 PDGFC -0.631050656251074 8.83643450601471e-05 -0.109641054681205 0.135071652654198 miRanda -0.101211829596614 1.66148480926124e-08 NA NA NA hsa-miR-330-3p PDGFC -0.427388106938151 0.00300489284414266 -0.109641054681205 0.135071652654198 mirMAP -0.132885747489891 3.05218892289238e-11 NA NA NA hsa-miR-330-5p PDGFC -0.262932095995605 0.0465226565966658 -0.109641054681205 0.135071652654198 miRanda -0.155809696055812 1.10163134717387e-12 NA NA NA hsa-miR-338-5p PDGFC -0.424003687569629 0.00246415720301323 -0.109641054681205 0.135071652654198 PITA;mirMAP -0.10503757056074 6.27789583606703e-07 NA NA NA hsa-miR-361-5p PDGFC 0.0107519600643302 0.882230614095565 -0.109641054681205 0.135071652654198 miRanda -0.224053941945922 8.20863492198512e-06 NA NA NA hsa-miR-375 PDGFC -0.0268401141324031 0.858358101444697 -0.109641054681205 0.135071652654198 miRNAWalker2_validate;miRanda -0.138081388519449 4.91964996860909e-13 NA NA NA hsa-miR-496 PDGFC -0.139833482232877 0.39597541862532 -0.109641054681205 0.135071652654198 miRanda -0.12723146771382 7.95788464975575e-13 NA NA NA hsa-miR-543 PDGFC -0.347737549779625 0.0157394585079683 -0.109641054681205 0.135071652654198 miRanda -0.157136479268045 1.37149911666354e-14 NA NA NA hsa-miR-582-3p PDGFC -0.11807589183011 0.304077332003677 -0.109641054681205 0.135071652654198 PITA -0.192828627052514 6.4461573596631e-14 NA NA NA hsa-miR-7-1-3p PDGFC -0.0894475316162393 0.37322359785108 -0.109641054681205 0.135071652654198 mirMAP -0.27684551728089 1.94909419223997e-22 NA NA NA hsa-miR-7-5p PDGFC -0.244254069762734 0.193173919522103 -0.109641054681205 0.135071652654198 miRNAWalker2_validate -0.132843663302499 1.03803908284809e-17 NA NA NA hsa-miR-346 PDGFD -0.577786425963268 2.10883270131593e-09 0.510250241810776 0.00492127208816491 miRanda -0.220480571429855 0.00717857364172508 NA NA NA hsa-miR-9-5p PDGFD -0.125377971246422 0.269896477802284 0.510250241810776 0.00492127208816491 MirTarget -1.28258540639006 6.51039308150004e-14 NA NA NA hsa-let-7a-2-3p PDGFRA 0.295235553592458 0.00290654476250609 -0.214227835759073 0.123422750860196 MirTarget -0.296334233533416 4.11922197722786e-07 NA NA NA hsa-let-7f-1-3p PDGFRA 0.110713086694053 0.21484524300518 -0.214227835759073 0.123422750860196 mirMAP -0.239111230215239 0.000205273554105078 NA NA NA hsa-miR-106a-5p PDGFRA 0.110074064773897 0.13045815990621 -0.214227835759073 0.123422750860196 MirTarget;miRNATAP -0.291101709809366 0.000522324338760065 NA NA NA hsa-miR-125a-3p PDGFRA 0.183834985432376 0.106230647107917 -0.214227835759073 0.123422750860196 miRanda -0.218704614786785 1.83272444389053e-05 NA NA NA hsa-miR-125a-5p PDGFRA -0.0833349424517387 0.325440200253607 -0.214227835759073 0.123422750860196 miRanda -0.584043237308749 1.35379706476998e-12 NA NA NA hsa-miR-132-3p PDGFRA -0.178379362833856 0.13335200877129 -0.214227835759073 0.123422750860196 miRNATAP -0.187831850273597 0.000250319391344747 NA NA NA hsa-miR-141-3p PDGFRA 0.41120561991992 0.000393344390969055 -0.214227835759073 0.123422750860196 MirTarget -0.212944157891481 2.31787320191516e-05 NA NA NA hsa-miR-142-5p PDGFRA 0.434884875454107 0.000575570345702788 -0.214227835759073 0.123422750860196 PITA;mirMAP;miRNATAP -0.255106354672294 1.29328581244106e-08 NA NA NA hsa-miR-143-3p PDGFRA 0.289829963197683 0.0420892105534401 -0.214227835759073 0.123422750860196 miRNATAP -0.188499057787187 3.61701378371554e-05 NA NA NA hsa-miR-146b-5p PDGFRA 0.441078059667297 0.000237619929889385 -0.214227835759073 0.123422750860196 miRanda -0.439250339471549 1.63797229980143e-19 NA NA NA hsa-miR-149-5p PDGFRA -0.0535821592029952 0.657713892012548 -0.214227835759073 0.123422750860196 MirTarget;miRNATAP -0.251126677334923 2.0149615804524e-07 NA NA NA hsa-miR-16-1-3p PDGFRA 0.346674816118499 1.86447850167636e-05 -0.214227835759073 0.123422750860196 MirTarget -0.225776587776573 0.0016066501712407 NA NA NA hsa-miR-184 PDGFRA -0.842534984406592 6.08844932016991e-08 -0.214227835759073 0.123422750860196 miRanda -0.153784899830709 2.69381514856598e-05 NA NA NA hsa-miR-186-5p PDGFRA 0.0606381894130505 0.514217717592464 -0.214227835759073 0.123422750860196 MirTarget -0.297882320589264 1.23111767407722e-05 NA NA NA hsa-miR-193a-3p PDGFRA 0.395602305834739 0.00182611787714301 -0.214227835759073 0.123422750860196 miRanda -0.273002234423519 2.46644840364766e-09 NA NA NA hsa-miR-199a-3p PDGFRA 0.41226331871076 0.000497136154474528 -0.214227835759073 0.123422750860196 MirTarget;PITA;miRNATAP -0.270733214461539 2.93296438648829e-08 NA NA NA hsa-miR-199a-5p PDGFRA 0.174889610847968 0.0900027418912454 -0.214227835759073 0.123422750860196 miRanda -0.26790376826415 1.965281983763e-06 NA NA NA hsa-miR-199b-3p PDGFRA 0.411848361704393 0.000517815011892379 -0.214227835759073 0.123422750860196 MirTarget;PITA;miRNATAP -0.269173280120204 3.28792716796774e-08 NA NA NA hsa-miR-199b-5p PDGFRA 0.436298593972862 0.00200225454383871 -0.214227835759073 0.123422750860196 miRanda -0.181040865656848 7.35837504952751e-06 NA NA NA hsa-miR-20b-5p PDGFRA 0.144541062989476 0.0992042333556543 -0.214227835759073 0.123422750860196 MirTarget;miRNATAP -0.280949056106333 7.10780599325753e-05 NA NA NA hsa-miR-212-3p PDGFRA -0.014112941209349 0.918360379512974 -0.214227835759073 0.123422750860196 miRNATAP -0.165210568743679 7.56823088897284e-05 NA NA NA hsa-miR-24-3p PDGFRA 0.133257261462871 0.212960921400853 -0.214227835759073 0.123422750860196 MirTarget;miRNATAP -0.258693453202796 1.426608452579e-05 NA NA NA hsa-miR-26a-5p PDGFRA 0.033823776747294 0.726610414342369 -0.214227835759073 0.123422750860196 MirTarget;mirMAP;miRNATAP -0.337817549965926 2.64891798560313e-06 NA NA NA hsa-miR-26b-5p PDGFRA -0.0984536538762768 0.231803769574623 -0.214227835759073 0.123422750860196 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.330492068006605 7.86276476912204e-05 NA NA NA hsa-miR-27a-3p PDGFRA 0.303760032895792 0.00457375391189806 -0.214227835759073 0.123422750860196 MirTarget;miRNATAP -0.332717954435526 7.42608425988857e-09 NA NA NA hsa-miR-27b-3p PDGFRA -0.0599187745243146 0.58208143475992 -0.214227835759073 0.123422750860196 MirTarget;miRNATAP -0.312048975764859 7.61491715727402e-08 NA NA NA hsa-miR-28-5p PDGFRA 0.104003572105781 0.153594705579534 -0.214227835759073 0.123422750860196 miRanda -0.408002281031611 1.50274553396473e-06 NA NA NA hsa-miR-29a-3p PDGFRA -0.224140851576083 0.0349516103550236 -0.214227835759073 0.123422750860196 MirTarget -0.433860748502012 5.47540666642455e-10 NA NA NA hsa-miR-29b-1-5p PDGFRA 0.191335428755774 0.00846436454790702 -0.214227835759073 0.123422750860196 mirMAP -0.444219655383209 1.48743564059219e-08 NA NA NA hsa-miR-29b-2-5p PDGFRA -0.26834261955727 0.00453760540520233 -0.214227835759073 0.123422750860196 mirMAP -0.403170180391648 4.54797630182334e-11 NA NA NA hsa-miR-29b-3p PDGFRA -0.178522712044497 0.0856106432165465 -0.214227835759073 0.123422750860196 MirTarget -0.479354783825126 2.78031130409556e-15 NA NA NA hsa-miR-29c-3p PDGFRA -0.372180390387259 0.00202634431973208 -0.214227835759073 0.123422750860196 MirTarget -0.325784473603734 3.2768258385201e-10 NA NA NA hsa-miR-320c PDGFRA 0.343259124189966 0.000248338401291051 -0.214227835759073 0.123422750860196 miRanda -0.25132609270931 6.63976805483441e-05 NA NA NA hsa-miR-330-5p PDGFRA -0.262932095995605 0.0465226565966658 -0.214227835759073 0.123422750860196 miRanda -0.122999029913756 0.00489006932093651 NA NA NA hsa-miR-335-3p PDGFRA 0.34540584335595 0.00043848660222294 -0.214227835759073 0.123422750860196 mirMAP -0.296573735389458 8.96271541553145e-07 NA NA NA hsa-miR-339-5p PDGFRA 0.273253751377152 0.0185300170790638 -0.214227835759073 0.123422750860196 miRanda -0.331337860958994 1.16346191528288e-11 NA NA NA hsa-miR-34a-5p PDGFRA 0.143472919835524 0.211283228567057 -0.214227835759073 0.123422750860196 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.507657602010947 6.25800263585505e-25 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-34c-5p PDGFRA 0.181931113688093 0.257266965617363 -0.214227835759073 0.123422750860196 MirTarget;PITA;miRanda;miRNATAP -0.238616457279072 8.42235088990927e-12 NA NA NA hsa-miR-362-3p PDGFRA 0.032375035235532 0.736465332563774 -0.214227835759073 0.123422750860196 miRanda -0.25592920204664 1.90006109239814e-05 NA NA NA hsa-miR-455-5p PDGFRA 0.332224239762 0.0106491358056238 -0.214227835759073 0.123422750860196 MirTarget;PITA;miRanda -0.206982425909943 2.64647669398927e-06 NA NA NA hsa-miR-488-3p PDGFRA -0.257955761012568 0.00280795162806256 -0.214227835759073 0.123422750860196 mirMAP -0.245006697838914 0.000325177624269067 NA NA NA hsa-miR-576-5p PDGFRA 0.106482276040047 0.194379152564166 -0.214227835759073 0.123422750860196 mirMAP -0.275734374551186 0.000105383234164016 NA NA NA hsa-miR-590-3p PDGFRA 0.312951515438396 0.000480455423843996 -0.214227835759073 0.123422750860196 miRanda;mirMAP -0.360558237867372 1.42959874478908e-08 NA NA NA hsa-miR-590-5p PDGFRA 0.16946027035949 0.0386004382081678 -0.214227835759073 0.123422750860196 miRanda -0.339783423553957 1.57951301556451e-06 NA NA NA hsa-miR-664a-3p PDGFRA 0.0413918462467198 0.611334357897022 -0.214227835759073 0.123422750860196 mirMAP -0.68336198484181 1.47148431801351e-22 NA NA NA hsa-miR-7-1-3p PDGFRA -0.0894475316162393 0.37322359785108 -0.214227835759073 0.123422750860196 mirMAP -0.241177783617488 2.86345919927891e-05 NA NA NA hsa-miR-9-5p PDGFRB -0.125377971246422 0.269896477802284 0.193259964403652 0.00272288258408316 MirTarget;miRNATAP -0.367539214293885 4.33000477969503e-12 NA NA NA hsa-miR-124-3p PGF -0.506026514549291 0.0078056370358648 -0.341184446598072 0.02198133567065 MirTarget;miRNATAP -0.12378981779743 0.000279266195514154 NA NA NA hsa-miR-142-3p PGF 0.558908907203977 1.37828834702416e-05 -0.341184446598072 0.02198133567065 miRanda -0.209524698619111 4.8489187207237e-05 NA NA NA hsa-miR-146b-5p PGF 0.441078059667297 0.000237619929889385 -0.341184446598072 0.02198133567065 miRanda -0.219423284623696 9.73569588345958e-05 NA NA NA hsa-miR-149-5p PGF -0.0535821592029952 0.657713892012548 -0.341184446598072 0.02198133567065 miRNATAP -0.335460001684344 4.97608776107746e-10 NA NA NA hsa-miR-184 PGF -0.842534984406592 6.08844932016991e-08 -0.341184446598072 0.02198133567065 miRanda -0.136337291100717 0.000950149149887701 NA NA NA hsa-miR-199b-5p PGF 0.436298593972862 0.00200225454383871 -0.341184446598072 0.02198133567065 miRanda -0.150774194706357 0.000927470972217645 NA NA NA hsa-miR-335-5p PGF 0.0938511632756978 0.336889056387694 -0.341184446598072 0.02198133567065 miRNATAP -0.314497501310152 2.85681687322176e-06 NA NA NA hsa-miR-34a-5p PGF 0.143472919835524 0.211283228567057 -0.341184446598072 0.02198133567065 miRNATAP -0.279835357608525 1.1066200175762e-06 NA NA NA hsa-miR-766-3p PGF -0.147747825439875 0.266658981351507 -0.341184446598072 0.02198133567065 MirTarget -0.244529156614663 3.20505159007913e-07 NA NA NA hsa-miR-146b-5p PIK3CA 0.441078059667297 0.000237619929889385 0.037489443318349 0.579330715365297 mirMAP -0.131612247931155 2.37773318343185e-08 NA NA NA hsa-miR-339-5p PIK3CA 0.273253751377152 0.0185300170790638 0.037489443318349 0.579330715365297 miRanda -0.104034425659594 8.90794530378182e-06 NA NA NA hsa-miR-361-5p PIK3CA 0.0107519600643302 0.882230614095565 0.037489443318349 0.579330715365297 mirMAP -0.180837597518142 0.000106487510577531 NA NA NA hsa-miR-501-5p PIK3CA 0.0878951859817452 0.309663377222443 0.037489443318349 0.579330715365297 mirMAP -0.121849868853655 0.000118457183740553 NA NA NA hsa-miR-130b-3p PIK3CB 0.503911467685709 9.46590588950823e-08 -0.219948641615068 6.65962821954743e-06 miRNATAP -0.103286697323809 1.47078743054601e-08 NA NA NA hsa-miR-19a-3p PIK3CB 0.0466707843731911 0.576818938277755 -0.219948641615068 6.65962821954743e-06 miRNATAP -0.106776286308973 5.5364329421429e-07 NA NA NA hsa-miR-19b-3p PIK3CB -0.0138427450847924 0.856506310673067 -0.219948641615068 6.65962821954743e-06 miRNATAP -0.144620281397534 1.13083007810642e-08 NA NA NA hsa-miR-25-3p PIK3CB 0.316649850160985 0.000777982468387578 -0.219948641615068 6.65962821954743e-06 miRNATAP -0.107740273525281 5.28619562870356e-06 NA NA NA hsa-miR-103a-3p PIK3R1 -0.147443193527362 0.128400914654149 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.281302889120328 4.63842851180526e-09 NA NA NA hsa-miR-106a-5p PIK3R1 0.110074064773897 0.13045815990621 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.141577511066847 0.000568718663709082 NA NA NA hsa-miR-106b-5p PIK3R1 0.167096183547615 0.0497544396383451 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.114620357579885 0.00229922204074265 NA NA NA hsa-miR-1301-3p PIK3R1 -0.105695714210758 0.152249184194132 -0.259275224308753 0.00106935451973482 MirTarget -0.230097168026832 5.13675721710063e-09 NA NA NA hsa-miR-150-5p PIK3R1 0.0645271721519611 0.513295658828718 -0.259275224308753 0.00106935451973482 MirTarget -0.105207403299517 0.000393418533820088 NA NA NA hsa-miR-15a-5p PIK3R1 0.142658985373611 0.0536219185009004 -0.259275224308753 0.00106935451973482 MirTarget -0.230258286136212 5.21596791619245e-07 NA NA NA hsa-miR-15b-5p PIK3R1 0.592863156692837 1.41971517354055e-10 -0.259275224308753 0.00106935451973482 MirTarget -0.235643490684548 5.7801231863435e-14 NA NA NA hsa-miR-16-2-3p PIK3R1 0.468816222075619 7.04377763166292e-05 -0.259275224308753 0.00106935451973482 MirTarget -0.139286207343494 2.58317956279833e-09 NA NA NA hsa-miR-16-5p PIK3R1 0.246024668671282 0.00346042804503716 -0.259275224308753 0.00106935451973482 MirTarget -0.121551450392141 0.00217223263389569 NA NA NA hsa-miR-185-5p PIK3R1 -0.0767432095218297 0.404113540276816 -0.259275224308753 0.00106935451973482 miRNATAP -0.168972197052794 1.52142067802957e-07 NA NA NA hsa-miR-186-5p PIK3R1 0.0606381894130505 0.514217717592464 -0.259275224308753 0.00106935451973482 mirMAP -0.273384834286173 4.58184035796298e-17 NA NA NA hsa-miR-199a-3p PIK3R1 0.41226331871076 0.000497136154474528 -0.259275224308753 0.00106935451973482 miRNATAP -0.150441413618647 2.58272678316472e-10 NA NA NA hsa-miR-199a-5p PIK3R1 0.174889610847968 0.0900027418912454 -0.259275224308753 0.00106935451973482 miRanda -0.169409376623758 6.00323276983558e-10 NA NA NA hsa-miR-199b-3p PIK3R1 0.411848361704393 0.000517815011892379 -0.259275224308753 0.00106935451973482 miRNATAP -0.149610269102807 2.9670988718931e-10 NA NA NA hsa-miR-199b-5p PIK3R1 0.436298593972862 0.00200225454383871 -0.259275224308753 0.00106935451973482 miRanda -0.158988773915679 1.96615064731078e-16 NA NA NA hsa-miR-200b-3p PIK3R1 0.245768526504511 0.0580744465744737 -0.259275224308753 0.00106935451973482 mirMAP -0.203398688722103 1.6080278648636e-21 NA NA NA hsa-miR-200c-3p PIK3R1 0.413752622631695 8.6936333715621e-06 -0.259275224308753 0.00106935451973482 mirMAP -0.313372851003899 1.11853298374691e-27 NA NA NA hsa-miR-21-5p PIK3R1 1.0504925175311 2.58081295984106e-11 -0.259275224308753 0.00106935451973482 miRNAWalker2_validate;MirTarget;miRNATAP -0.192193122796698 2.35557430088274e-23 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 0.0437233965539527 0.639996108995995 -0.259275224308753 0.00106935451973482 mirMAP -0.26421716056902 5.35024336821731e-19 NA NA NA hsa-miR-221-3p PIK3R1 -0.0109507285071775 0.936440693394519 -0.259275224308753 0.00106935451973482 MirTarget -0.125242954911868 1.02528886125279e-09 NA NA NA hsa-miR-222-3p PIK3R1 0.107117065575197 0.423818119725697 -0.259275224308753 0.00106935451973482 MirTarget -0.132930686168698 1.29543187744781e-10 NA NA NA hsa-miR-28-5p PIK3R1 0.104003572105781 0.153594705579534 -0.259275224308753 0.00106935451973482 miRanda -0.263804174247158 1.47407900801522e-10 NA NA NA hsa-miR-29b-3p PIK3R1 -0.178522712044497 0.0856106432165465 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.145678229090259 1.47483484512088e-06 NA NA NA hsa-miR-320a PIK3R1 0.092135599636725 0.243028758989929 -0.259275224308753 0.00106935451973482 miRNATAP -0.135112165926423 0.00256497204146449 NA NA NA hsa-miR-320c PIK3R1 0.343259124189966 0.000248338401291051 -0.259275224308753 0.00106935451973482 miRNATAP -0.100797336995439 0.0011155444118643 NA NA NA hsa-miR-361-5p PIK3R1 0.0107519600643302 0.882230614095565 -0.259275224308753 0.00106935451973482 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.28102979614435 4.07903189307061e-09 NA NA NA hsa-miR-374a-3p PIK3R1 0.176226170437625 0.0343958848425446 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.321250741910251 7.52372972851822e-15 NA NA NA hsa-miR-424-5p PIK3R1 0.25140374049676 0.00709934939774983 -0.259275224308753 0.00106935451973482 MirTarget -0.179589895147171 9.52256678975884e-09 NA NA NA hsa-miR-455-3p PIK3R1 0.512701816402104 0.000459755983280155 -0.259275224308753 0.00106935451973482 MirTarget;PITA;miRNATAP -0.161697245880861 9.23450362337655e-18 NA NA NA hsa-miR-532-3p PIK3R1 0.150624483952741 0.0599635132177191 -0.259275224308753 0.00106935451973482 MirTarget -0.152797062588971 2.75979429090484e-05 NA NA NA hsa-miR-542-3p PIK3R1 0.0835995677900829 0.403838744494071 -0.259275224308753 0.00106935451973482 MirTarget;PITA;miRanda -0.126538995109648 4.83333922747737e-05 NA NA NA hsa-miR-548b-3p PIK3R1 0.340474544210108 0.00224491592019745 -0.259275224308753 0.00106935451973482 mirMAP -0.215757322792441 3.83990685247808e-18 NA NA NA hsa-miR-589-3p PIK3R1 0.00739371736361305 0.927768051649329 -0.259275224308753 0.00106935451973482 mirMAP -0.128475712773886 0.000234342022369328 NA NA NA hsa-miR-590-3p PIK3R1 0.312951515438396 0.000480455423843996 -0.259275224308753 0.00106935451973482 miRanda;mirMAP -0.281948259643294 1.55243456524174e-20 NA NA NA hsa-miR-590-5p PIK3R1 0.16946027035949 0.0386004382081678 -0.259275224308753 0.00106935451973482 MirTarget;PITA;miRanda;miRNATAP -0.237039982006307 4.44595475697952e-12 NA NA NA hsa-miR-93-5p PIK3R1 0.139766237971122 0.101057320076629 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.261542441732551 2.52352152477154e-07 NA NA NA hsa-miR-125a-3p PIK3R2 0.183834985432376 0.106230647107917 0.0588428389717066 0.330993461191286 miRanda -0.129596879826368 7.29774749644301e-14 NA NA NA hsa-miR-135a-5p PIK3R2 -0.122734612943241 0.196985964641886 0.0588428389717066 0.330993461191286 MirTarget;miRNATAP -0.131986778854444 6.81341317924018e-10 NA NA NA hsa-miR-28-5p PIK3R2 0.104003572105781 0.153594705579534 0.0588428389717066 0.330993461191286 miRanda -0.220439409614541 1.97006000122873e-14 NA NA NA hsa-miR-30a-5p PIK3R2 -0.062942936611238 0.513851954700252 0.0588428389717066 0.330993461191286 miRNATAP -0.422270293356803 9.55851299393926e-41 NA NA NA hsa-miR-30b-5p PIK3R2 -0.0858101016322106 0.263243418521854 0.0588428389717066 0.330993461191286 miRNATAP -0.124149959343624 7.09161751121272e-05 NA NA NA hsa-miR-30c-5p PIK3R2 -0.0469114469943097 0.565934557464627 0.0588428389717066 0.330993461191286 miRNAWalker2_validate;miRNATAP -0.240340425585456 4.99963373312426e-15 NA NA NA hsa-miR-30d-5p PIK3R2 -0.0607010868720046 0.471410043548794 0.0588428389717066 0.330993461191286 miRNATAP -0.157898559984916 9.76384983421278e-06 NA NA NA hsa-miR-30e-5p PIK3R2 0.0764521828640934 0.41904991629622 0.0588428389717066 0.330993461191286 miRNATAP -0.28288573453624 2.98060149038092e-23 NA NA NA hsa-miR-331-3p PIK3R2 0.0126984726684189 0.905175053956974 0.0588428389717066 0.330993461191286 MirTarget -0.109375813751675 5.11486213404741e-09 NA NA NA hsa-miR-339-5p PIK3R2 0.273253751377152 0.0185300170790638 0.0588428389717066 0.330993461191286 miRanda -0.141580109769359 1.93632849649246e-17 NA NA NA hsa-miR-34a-5p PIK3R2 0.143472919835524 0.211283228567057 0.0588428389717066 0.330993461191286 MirTarget -0.127777793508925 2.24958566486742e-13 NA NA NA hsa-miR-9-3p PIK3R3 -0.184945845984695 0.0290051908009009 0.266207970572364 5.77735138484935e-05 mirMAP -0.147414732691119 0.000303043365501486 NA NA NA hsa-miR-9-5p PIK3R3 -0.125377971246422 0.269896477802284 0.266207970572364 5.77735138484935e-05 miRNATAP -0.234645741849474 2.452186835562e-05 NA NA NA hsa-miR-106b-5p PLA2G12A 0.167096183547615 0.0497544396383451 -0.181962072480256 2.70460580179857e-05 mirMAP -0.123794031417231 8.40767531912829e-12 NA NA NA hsa-miR-93-5p PLA2G12A 0.139766237971122 0.101057320076629 -0.181962072480256 2.70460580179857e-05 mirMAP -0.134716211565272 5.93753764091159e-08 NA NA NA hsa-miR-491-5p PLA2G2A -0.749881113074983 8.22859263179194e-09 1.29188933567535 4.98156559625774e-07 miRanda -0.225010501106316 0.00842290234172622 NA NA NA hsa-miR-139-5p PLA2G4A -0.647754756897633 2.15378307237163e-06 0.459553101816434 3.96979969592525e-06 miRanda -0.196719913317323 1.19655643220759e-09 NA NA NA hsa-miR-2355-3p PLA2G6 0.186207523505296 0.0525918026993012 -0.329810877626427 6.39462398247452e-09 MirTarget -0.136794319081761 8.98869883320535e-10 NA NA NA hsa-miR-30a-3p PLA2G6 0.0655410309550977 0.509541256241954 -0.329810877626427 6.39462398247452e-09 miRNATAP -0.179375158849384 2.09226484033404e-10 NA NA NA hsa-miR-30d-3p PLA2G6 0.0854049347792898 0.20691254801121 -0.329810877626427 6.39462398247452e-09 miRNATAP -0.157387082946513 1.14186003565846e-06 NA NA NA hsa-miR-324-5p PLA2G6 0.0183370482495953 0.842996782677271 -0.329810877626427 6.39462398247452e-09 miRanda -0.112311121172656 2.84645215254445e-06 NA NA NA hsa-miR-182-5p PLD1 -0.146726537592027 0.389265298808118 -0.0761605221803379 0.51521305812009 MirTarget;miRNATAP -0.103845686076138 0.000953243806474978 NA NA NA hsa-miR-195-3p PLD1 0.100105455903079 0.133362389112338 -0.0761605221803379 0.51521305812009 mirMAP -0.250345798118178 0.00154273142127176 NA NA NA hsa-miR-892a PLD1 -0.242011750672218 0.136146245118012 -0.0761605221803379 0.51521305812009 miRNATAP -0.104013879224954 0.00130847400276905 NA NA NA hsa-miR-9-5p PLD1 -0.125377971246422 0.269896477802284 -0.0761605221803379 0.51521305812009 mirMAP -0.773804428318232 2.15598367950367e-12 NA NA NA hsa-miR-138-5p PLD2 -0.616087649920851 1.35200027885729e-05 0.0121780252430757 0.838496276273208 MirTarget -0.11260331070407 6.83689923086335e-13 NA NA NA hsa-miR-195-3p PRKACB 0.100105455903079 0.133362389112338 -0.220744787859509 0.000769904555544923 mirMAP -0.108467815706043 0.00216235374196591 NA NA NA hsa-miR-19b-3p PRKACB -0.0138427450847924 0.856506310673067 -0.220744787859509 0.000769904555544923 miRNAWalker2_validate;MirTarget;miRNATAP -0.139345436156152 4.31724651745926e-05 NA NA NA hsa-miR-93-5p PRKACB 0.139766237971122 0.101057320076629 -0.220744787859509 0.000769904555544923 miRNAWalker2_validate -0.173086797632099 2.75308372550666e-05 NA NA NA hsa-miR-146b-5p PRKCA 0.441078059667297 0.000237619929889385 -0.289954367502515 3.07027667899011e-05 mirMAP -0.14319708794989 9.06517098676715e-13 NA NA NA hsa-miR-186-5p PRKCA 0.0606381894130505 0.514217717592464 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.150359410939945 4.84077626913968e-08 NA NA NA hsa-miR-1976 PRKCA 0.127074435034705 0.277235601775457 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.108813705938178 3.46283535790712e-08 NA NA NA hsa-miR-200c-3p PRKCA 0.413752622631695 8.6936333715621e-06 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.178242109766722 4.41123343449352e-13 NA NA NA hsa-miR-22-5p PRKCA 0.0437233965539527 0.639996108995995 -0.289954367502515 3.07027667899011e-05 mirMAP -0.109722618118012 1.49794234596401e-05 NA NA NA hsa-miR-24-2-5p PRKCA 0.285455874963858 0.00610163594056254 -0.289954367502515 3.07027667899011e-05 miRNAWalker2_validate -0.126181943667759 1.61489847928406e-08 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-27b-5p PRKCA 0.224282840351546 0.00630787296051719 -0.289954367502515 3.07027667899011e-05 mirMAP -0.177695243384062 3.0717917979023e-10 NA NA NA hsa-miR-339-5p PRKCA 0.273253751377152 0.0185300170790638 -0.289954367502515 3.07027667899011e-05 mirMAP -0.144247762214447 3.06350803308541e-13 NA NA NA hsa-miR-374a-3p PRKCA 0.176226170437625 0.0343958848425446 -0.289954367502515 3.07027667899011e-05 mirMAP -0.183155883331884 1.46022453353189e-07 NA NA NA hsa-miR-452-5p PRKCA 0.599327068454211 1.02031931068531e-05 -0.289954367502515 3.07027667899011e-05 mirMAP -0.107144316873697 1.95734554580544e-10 NA NA NA hsa-miR-500a-5p PRKCA 0.0634452729978863 0.396072382601677 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.184254955997398 3.38268451218896e-09 NA NA NA hsa-miR-501-5p PRKCA 0.0878951859817452 0.309663377222443 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.110873198819 4.40374990873549e-05 NA NA NA hsa-miR-505-3p PRKCA 0.115486008167472 0.109833720698312 -0.289954367502515 3.07027667899011e-05 miRNAWalker2_validate -0.183149886354061 7.20630466764891e-08 NA NA NA hsa-miR-505-5p PRKCA 0.0973008785018434 0.183209581426791 -0.289954367502515 3.07027667899011e-05 mirMAP -0.102672793703942 0.00160299774148607 NA NA NA hsa-miR-548b-3p PRKCA 0.340474544210108 0.00224491592019745 -0.289954367502515 3.07027667899011e-05 PITA;miRNATAP -0.107410539931332 3.63814329290144e-07 NA NA NA hsa-miR-550a-3p PRKCA 0.311518294008363 0.0015285640451888 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.135787662750574 7.76840887594873e-09 NA NA NA hsa-miR-590-3p PRKCA 0.312951515438396 0.000480455423843996 -0.289954367502515 3.07027667899011e-05 PITA;miRanda;mirMAP;miRNATAP -0.152536946782924 3.436144371863e-09 NA NA NA hsa-miR-93-3p PRKCA 0.0778767956494004 0.272224943247293 -0.289954367502515 3.07027667899011e-05 mirMAP -0.146551656012825 2.11995627214635e-05 NA NA NA hsa-miR-155-5p PRKCB 0.969837380981085 5.86551495710056e-15 -0.682239380816002 3.52750339218814e-07 mirMAP -0.235836634520576 1.53174038755186e-07 NA NA NA hsa-miR-195-3p PRKCB 0.100105455903079 0.133362389112338 -0.682239380816002 3.52750339218814e-07 mirMAP -0.359971667645682 5.30224329291627e-05 NA NA NA hsa-miR-200c-3p PRKCB 0.413752622631695 8.6936333715621e-06 -0.682239380816002 3.52750339218814e-07 MirTarget;miRNATAP -0.208521490107408 0.000752162039048593 NA NA NA hsa-miR-23a-3p PRKCB 0.334693010651106 0.00144448147063433 -0.682239380816002 3.52750339218814e-07 mirMAP -0.27145045765466 1.33239615330638e-05 NA NA NA hsa-miR-27a-3p PRKCB 0.303760032895792 0.00457375391189806 -0.682239380816002 3.52750339218814e-07 MirTarget;miRNATAP -0.215141700970757 0.000219945845412233 NA NA NA hsa-miR-450b-5p PRKCB 0.270544879013992 0.00801537838499562 -0.682239380816002 3.52750339218814e-07 miRNATAP -0.161638000758075 0.00497309309812017 NA NA NA hsa-miR-590-3p PRKCB 0.312951515438396 0.000480455423843996 -0.682239380816002 3.52750339218814e-07 mirMAP -0.223842383414072 0.000503630468502308 NA NA NA hsa-miR-320a PRKCG 0.092135599636725 0.243028758989929 -1.05900738460984 1.8225118256495e-06 MirTarget;miRanda -0.531753093228863 0.000615460761538157 NA NA NA hsa-miR-320b PRKCG 0.283477746304177 0.0005953763020907 -1.05900738460984 1.8225118256495e-06 MirTarget;miRanda -0.367797376788092 0.00188611730145367 NA NA NA hsa-miR-320c PRKCG 0.343259124189966 0.000248338401291051 -1.05900738460984 1.8225118256495e-06 MirTarget;miRanda -0.485123776133657 5.54850190547458e-06 NA NA NA hsa-miR-532-3p PRKCG 0.150624483952741 0.0599635132177191 -1.05900738460984 1.8225118256495e-06 miRNATAP -0.329482037092211 0.00954229687515554 NA NA NA hsa-miR-19a-3p PTPN11 0.0466707843731911 0.576818938277755 -0.128832291150953 0.0425631030517416 mirMAP -0.107814047213024 3.87455311201701e-06 NA NA NA hsa-miR-19b-3p PTPN11 -0.0138427450847924 0.856506310673067 -0.128832291150953 0.0425631030517416 mirMAP -0.14042623414932 4.26553855796372e-07 NA NA NA hsa-miR-320a PTPN11 0.092135599636725 0.243028758989929 -0.128832291150953 0.0425631030517416 miRNAWalker2_validate;mirMAP -0.10812909554291 0.000266325538481357 NA NA NA hsa-miR-106b-5p RAB5B 0.167096183547615 0.0497544396383451 -0.180428485758533 0.000685347333081572 miRNATAP -0.113209817770137 7.95864928956667e-12 NA NA NA hsa-miR-17-5p RAB5B 0.0975751369167082 0.20621110214601 -0.180428485758533 0.000685347333081572 miRNAWalker2_validate;TargetScan;miRNATAP -0.114377396988756 1.35991386354011e-08 NA NA NA hsa-miR-93-5p RAB5B 0.139766237971122 0.101057320076629 -0.180428485758533 0.000685347333081572 miRNAWalker2_validate;miRNATAP -0.215708893139884 1.09339516546585e-22 NA NA NA hsa-miR-124-3p RAC2 -0.506026514549291 0.0078056370358648 0.543102090563642 6.32748728882766e-07 mirMAP -0.16328824721264 5.64768337601236e-11 NA NA NA hsa-miR-129-5p RAC2 -0.567133990117126 0.00116152215679936 0.543102090563642 6.32748728882766e-07 miRanda -0.163216019318866 3.88418743152648e-09 NA NA NA hsa-miR-491-5p RAC2 -0.749881113074983 8.22859263179194e-09 0.543102090563642 6.32748728882766e-07 miRanda -0.143477171929978 6.8541464600559e-05 NA NA NA hsa-miR-125a-5p RAC3 -0.0833349424517387 0.325440200253607 -0.0694477011024395 0.398923087359439 PITA -0.255720823416584 1.87026446294698e-07 NA NA NA hsa-miR-30c-2-3p RAC3 -0.18630560418806 0.0313113706136533 -0.0694477011024395 0.398923087359439 miRNAWalker2_validate -0.340394704089941 3.11880878701484e-16 NA NA NA hsa-miR-590-3p RAC3 0.312951515438396 0.000480455423843996 -0.0694477011024395 0.398923087359439 miRanda -0.139701651516001 0.000218392196649336 NA NA NA hsa-miR-671-5p RAC3 0.379677704170736 0.000129391032677459 -0.0694477011024395 0.398923087359439 miRNATAP -0.228245307641295 7.53346315814315e-12 NA NA NA hsa-miR-125a-5p RAF1 -0.0833349424517387 0.325440200253607 -0.00553586733389189 0.905894621254653 miRanda -0.122061217158812 1.14719678269113e-13 NA NA NA hsa-miR-146b-3p RAF1 0.283486177568242 0.0118918188864879 -0.00553586733389189 0.905894621254653 MirTarget;PITA;miRNATAP -0.122160060310276 3.66962239698306e-36 NA NA NA hsa-miR-23b-3p RAF1 0.0476610245860094 0.630277683372344 -0.00553586733389189 0.905894621254653 miRNAWalker2_validate -0.142246538184778 8.25666529544947e-31 NA NA NA hsa-miR-484 RAF1 -0.0190828819137732 0.802298900989652 -0.00553586733389189 0.905894621254653 MirTarget -0.126030948035335 1.89321721164606e-15 NA NA NA hsa-miR-7-1-3p RALA -0.0894475316162393 0.37322359785108 0.0343635501749047 0.43071423817895 mirMAP -0.103211424702045 2.2174426221616e-20 NA NA NA hsa-miR-9-5p RALB -0.125377971246422 0.269896477802284 0.0480666362089162 0.34992690016152 miRNATAP -0.403349876500773 5.57227324332531e-24 NA NA NA hsa-miR-128-3p RAP1B -0.781932174412672 7.1812756321342e-10 0.142944911590152 0.00328482194864398 MirTarget -0.147230046784345 1.53070842148117e-27 25017996 miR 128 and miR 149 enhance the chemosensitivity of temozolomide by Rap1B mediated cytoskeletal remodeling in glioblastoma glioblastoma hsa-miR-139-5p RAP1B -0.647754756897633 2.15378307237163e-06 0.142944911590152 0.00328482194864398 miRanda;miRNATAP -0.121287779626316 5.14664639145908e-24 22642900 Regulation of RAP1B by miR 139 suppresses human colorectal carcinoma cell proliferation; Potential functions of miR-139 were evaluated in colorectal carcinoma cell lines SW480 SW620 LS174 T and HCT116 using miR-139 mimics anti-miR-139 and siRNA RAP1B; Mechanistic studies revealed that miR-139 repressed the activity of a reporter gene fused to the 3'-untranslated region of RAP1B whereas miR-139 silencing up-regulated the expression of the reporter gene; RNAi-mediated knockdown of RAP1B phenocopied the antiproliferative effect of miR-139 whereas the overexpression of RAP1B blocked miR-139-mediated antiproliferative effects in CRC cells; Taken together these results demonstrated that miR-139 decreases proliferation by directly targeting RAP1B defining miR-139 as a new putative tumour suppressor miRNA in CRC colorectal cancer hsa-miR-767-5p RAP1B -0.551653504513145 2.61109058244854e-05 0.142944911590152 0.00328482194864398 miRNATAP -0.11071617688106 5.88393562192962e-19 NA NA NA hsa-miR-9-5p RAP1B -0.125377971246422 0.269896477802284 0.142944911590152 0.00328482194864398 miRNATAP -0.345880158918626 6.03962874526603e-23 NA NA NA hsa-miR-320c RAPGEF5 0.343259124189966 0.000248338401291051 -0.364396586218026 0.00362776990194872 mirMAP -0.155967436371397 0.00966274028812718 NA NA NA hsa-miR-629-3p RAPGEF5 0.318874955109265 0.00062631284800046 -0.364396586218026 0.00362776990194872 MirTarget -0.209620006690208 0.000373263097953329 NA NA NA hsa-miR-9-3p RASA1 -0.184945845984695 0.0290051908009009 -0.0629231856339159 0.184047228298798 MirTarget;miRNATAP -0.146769575121925 9.70434852945778e-09 NA NA NA hsa-miR-30b-5p RASA2 -0.0858101016322106 0.263243418521854 0.00582759452067383 0.957666009906005 mirMAP -0.265041907546631 0.000426366239598471 NA NA NA hsa-miR-30c-5p RASA2 -0.0469114469943097 0.565934557464627 0.00582759452067383 0.957666009906005 mirMAP -0.405938794612823 6.0314363327211e-08 NA NA NA hsa-miR-186-5p RASA3 0.0606381894130505 0.514217717592464 -0.0197333046849204 0.745866396792429 miRNATAP -0.234514125568644 7.43681996804454e-19 NA NA NA hsa-miR-15b-5p RASA4 0.592863156692837 1.41971517354055e-10 -0.263491547014481 0.00105984827175041 mirMAP -0.197996410595604 9.59238116592963e-08 NA NA NA hsa-miR-16-5p RASA4 0.246024668671282 0.00346042804503716 -0.263491547014481 0.00105984827175041 mirMAP -0.270479359574294 3.37681308190607e-09 NA NA NA hsa-miR-181b-5p RASA4 0.0260899284211646 0.768941836912518 -0.263491547014481 0.00105984827175041 MirTarget -0.186147147201346 5.84176748147663e-05 NA NA NA hsa-miR-186-5p RASA4 0.0606381894130505 0.514217717592464 -0.263491547014481 0.00105984827175041 mirMAP -0.106411122822372 0.00659983788040502 NA NA NA hsa-miR-194-3p RASA4 -0.016713562294121 0.844070305824766 -0.263491547014481 0.00105984827175041 mirMAP -0.153035644440773 0.000119809382820769 NA NA NA hsa-miR-2355-5p RASA4 0.00808596988211185 0.916165501155096 -0.263491547014481 0.00105984827175041 mirMAP -0.124396612932264 0.00597681683501697 NA NA NA hsa-miR-28-5p RASA4 0.104003572105781 0.153594705579534 -0.263491547014481 0.00105984827175041 miRanda -0.12634705715696 0.00972770285089163 NA NA NA hsa-miR-320b RASA4 0.283477746304177 0.0005953763020907 -0.263491547014481 0.00105984827175041 miRanda -0.122680458799682 0.00207487192952529 NA NA NA hsa-miR-331-3p RASA4 0.0126984726684189 0.905175053956974 -0.263491547014481 0.00105984827175041 mirMAP -0.16746508040677 6.98557152564739e-08 NA NA NA hsa-miR-34c-5p RASA4 0.181931113688093 0.257266965617363 -0.263491547014481 0.00105984827175041 miRanda -0.110139122847127 4.46380032899686e-08 NA NA NA hsa-miR-424-5p RASA4 0.25140374049676 0.00709934939774983 -0.263491547014481 0.00105984827175041 mirMAP -0.149603532901178 4.872309805806e-05 NA NA NA hsa-miR-590-3p RASA4 0.312951515438396 0.000480455423843996 -0.263491547014481 0.00105984827175041 miRanda;mirMAP -0.113831370657372 0.00195209392782833 NA NA NA hsa-miR-940 RASA4 -0.0183807673806575 0.881747775878136 -0.263491547014481 0.00105984827175041 mirMAP -0.155991037489015 2.99528174819859e-09 NA NA NA hsa-miR-155-5p RASAL2 0.969837380981085 5.86551495710056e-15 -0.123920404819144 0.0439236357678063 MirTarget -0.102926623446007 4.99404800638403e-08 NA NA NA hsa-miR-26b-5p RASAL2 -0.0984536538762768 0.231803769574623 -0.123920404819144 0.0439236357678063 miRNAWalker2_validate -0.162020168366654 4.14574163645752e-06 NA NA NA hsa-miR-30a-3p RASAL2 0.0655410309550977 0.509541256241954 -0.123920404819144 0.0439236357678063 mirMAP -0.111970639242748 0.000442902550942899 NA NA NA hsa-miR-339-5p RASAL2 0.273253751377152 0.0185300170790638 -0.123920404819144 0.0439236357678063 PITA -0.103678869954837 6.17075794455201e-07 NA NA NA hsa-miR-374a-3p RASAL2 0.176226170437625 0.0343958848425446 -0.123920404819144 0.0439236357678063 mirMAP -0.135850915155422 0.000187450624428858 NA NA NA hsa-miR-9-3p RASAL2 -0.184945845984695 0.0290051908009009 -0.123920404819144 0.0439236357678063 mirMAP -0.186292893686718 1.58245880482836e-06 NA NA NA hsa-miR-767-3p RASAL3 -0.429854368420513 0.000821445291167688 0.179428926536794 0.0982564979894957 miRNATAP -0.254392463523954 5.46091320323767e-12 NA NA NA hsa-miR-320a RASGRF1 0.092135599636725 0.243028758989929 -1.06685630637769 3.5468899485581e-11 miRanda -0.55677593830522 5.47838003787159e-07 NA NA NA hsa-miR-320b RASGRF1 0.283477746304177 0.0005953763020907 -1.06685630637769 3.5468899485581e-11 miRanda -0.424437233934571 5.3242357601755e-07 NA NA NA hsa-miR-320c RASGRF1 0.343259124189966 0.000248338401291051 -1.06685630637769 3.5468899485581e-11 miRanda -0.343951950195442 7.85406485832464e-06 NA NA NA hsa-miR-3913-5p RASGRF1 0.276883251911602 0.00186113779811511 -1.06685630637769 3.5468899485581e-11 mirMAP -0.381295456964508 1.31260834162521e-06 NA NA NA hsa-miR-320a RASGRF2 0.092135599636725 0.243028758989929 -0.506147835992184 9.00596821868115e-05 miRNATAP -0.499305411034718 2.45356456577931e-08 NA NA NA hsa-miR-320b RASGRF2 0.283477746304177 0.0005953763020907 -0.506147835992184 9.00596821868115e-05 miRNATAP -0.198903176007538 0.00390323705056096 NA NA NA hsa-miR-320c RASGRF2 0.343259124189966 0.000248338401291051 -0.506147835992184 9.00596821868115e-05 miRNATAP -0.293104381895496 2.35930001083077e-06 NA NA NA hsa-miR-450b-5p RASGRF2 0.270544879013992 0.00801537838499562 -0.506147835992184 9.00596821868115e-05 MirTarget -0.170204967140847 0.00269856846164706 NA NA NA hsa-miR-93-5p RASGRF2 0.139766237971122 0.101057320076629 -0.506147835992184 9.00596821868115e-05 MirTarget -0.307430286608741 0.00291957759034578 NA NA NA hsa-miR-17-3p RASGRP1 0.0217768908350733 0.801140991374649 -0.461228311355649 9.75402712538101e-05 MirTarget -0.282419356096531 3.28278622807681e-05 NA NA NA hsa-miR-21-5p RASGRP1 1.0504925175311 2.58081295984106e-11 -0.461228311355649 9.75402712538101e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.209857300737546 6.88556700859861e-09 NA NA NA hsa-miR-320a RASGRP1 0.092135599636725 0.243028758989929 -0.461228311355649 9.75402712538101e-05 miRanda -0.40023445800445 7.63439404259571e-07 NA NA NA hsa-miR-320b RASGRP1 0.283477746304177 0.0005953763020907 -0.461228311355649 9.75402712538101e-05 miRanda -0.217132175899859 0.000461300440718023 NA NA NA hsa-miR-452-5p RASGRP1 0.599327068454211 1.02031931068531e-05 -0.461228311355649 9.75402712538101e-05 MirTarget -0.158970519883108 2.01820089565616e-05 NA NA NA hsa-miR-590-3p RASGRP1 0.312951515438396 0.000480455423843996 -0.461228311355649 9.75402712538101e-05 PITA;miRanda;mirMAP -0.190087220302925 0.000894629573569115 NA NA NA hsa-miR-9-5p RASSF5 -0.125377971246422 0.269896477802284 0.189334227395315 0.0362127560705738 mirMAP -0.941664894157656 2.50873203731748e-31 NA NA NA hsa-miR-1224-5p RELA -0.53941068839383 0.00201058335769201 0.0739196932169914 0.126314845681798 mirMAP -0.105338562253176 5.76511309726817e-46 NA NA NA hsa-miR-138-5p RELA -0.616087649920851 1.35200027885729e-05 0.0739196932169914 0.126314845681798 miRNATAP -0.118615517312994 4.30114332551203e-37 NA NA NA hsa-miR-324-5p RELA 0.0183370482495953 0.842996782677271 0.0739196932169914 0.126314845681798 miRNAWalker2_validate;miRanda -0.154645221576587 4.11812534839311e-25 NA NA NA hsa-miR-330-5p RELA -0.262932095995605 0.0465226565966658 0.0739196932169914 0.126314845681798 miRanda -0.120880678711014 2.77817174522426e-33 NA NA NA hsa-miR-488-3p RELA -0.257955761012568 0.00280795162806256 0.0739196932169914 0.126314845681798 mirMAP -0.149905441066056 1.6489641903294e-20 NA NA NA hsa-miR-769-5p RELA -0.320572895263071 0.00425481410304398 0.0739196932169914 0.126314845681798 miRNATAP -0.185846508366017 6.56909022979932e-59 NA NA NA hsa-miR-940 RELA -0.0183807673806575 0.881747775878136 0.0739196932169914 0.126314845681798 mirMAP -0.130602708311796 2.82198893322046e-34 NA NA NA hsa-miR-17-5p RGL1 0.0975751369167082 0.20621110214601 -0.208515229681984 0.000184231837181471 MirTarget;TargetScan;miRNATAP -0.122094495072931 7.48846633276966e-05 NA NA NA hsa-miR-19a-3p RGL1 0.0466707843731911 0.576818938277755 -0.208515229681984 0.000184231837181471 MirTarget;miRNATAP -0.130611925607323 4.38942382202663e-08 NA NA NA hsa-miR-19b-3p RGL1 -0.0138427450847924 0.856506310673067 -0.208515229681984 0.000184231837181471 MirTarget;miRNATAP -0.188429747744041 2.52405449795716e-11 NA NA NA hsa-miR-20a-5p RGL1 -0.0115865752288853 0.887069448776018 -0.208515229681984 0.000184231837181471 MirTarget;miRNATAP -0.182888361795593 5.44710573970245e-11 NA NA NA hsa-miR-92a-3p RGL1 0.0407239381334659 0.643983393805961 -0.208515229681984 0.000184231837181471 MirTarget -0.109245774498218 0.00168594755472293 NA NA NA hsa-miR-93-5p RGL1 0.139766237971122 0.101057320076629 -0.208515229681984 0.000184231837181471 MirTarget;miRNATAP -0.180570434632288 1.67230712134547e-07 NA NA NA hsa-miR-125a-5p RGL2 -0.0833349424517387 0.325440200253607 0.128895680804986 0.0133863109087458 miRanda -0.161272893357123 1.59232741426932e-10 NA NA NA hsa-miR-592 RHOA 0.0170005651576508 0.876633091134809 0.0216749062113539 0.702384833178432 PITA -0.113898466932858 4.37696740723643e-26 NA NA NA hsa-miR-296-5p RIN1 -0.0192165981442809 0.870822664524408 0.548469729117402 1.44693377080992e-05 miRNATAP -0.174004049745625 0.000238513821247061 NA NA NA hsa-let-7b-3p RRAS2 -0.00495618733298731 0.952288980686967 -0.0913272811525756 0.135156066352621 mirMAP;miRNATAP -0.131484100235838 2.53819396047347e-05 NA NA NA hsa-let-7f-1-3p RRAS2 0.110713086694053 0.21484524300518 -0.0913272811525756 0.135156066352621 mirMAP -0.143094236242528 2.11724325082796e-07 NA NA NA hsa-miR-106a-5p RRAS2 0.110074064773897 0.13045815990621 -0.0913272811525756 0.135156066352621 miRNATAP -0.12317886200846 0.000658480618678879 NA NA NA hsa-miR-106b-5p RRAS2 0.167096183547615 0.0497544396383451 -0.0913272811525756 0.135156066352621 miRNATAP -0.197109868266015 1.60059931740107e-09 NA NA NA hsa-miR-124-3p RRAS2 -0.506026514549291 0.0078056370358648 -0.0913272811525756 0.135156066352621 miRNAWalker2_validate -0.125689178830533 1.33296453127719e-23 NA NA NA hsa-miR-127-5p RRAS2 -0.128719168376827 0.401210814502785 -0.0913272811525756 0.135156066352621 MirTarget;PITA;miRNATAP -0.131367552633205 6.54548952205885e-16 NA NA NA hsa-miR-137 RRAS2 -0.924849266740909 1.546832202049e-06 -0.0913272811525756 0.135156066352621 miRanda -0.100839406182356 4.01361292382003e-16 NA NA NA hsa-miR-140-3p RRAS2 -0.123864258867705 0.14796686619449 -0.0913272811525756 0.135156066352621 MirTarget;PITA;miRNATAP -0.165657058581711 1.50814007589585e-05 NA NA NA hsa-miR-185-5p RRAS2 -0.0767432095218297 0.404113540276816 -0.0913272811525756 0.135156066352621 MirTarget -0.108339763839803 0.000144130105015975 NA NA NA hsa-miR-193b-3p RRAS2 0.0766333116224072 0.324723824453143 -0.0913272811525756 0.135156066352621 MirTarget -0.118927328208489 0.0004010370015633 NA NA NA hsa-miR-19b-3p RRAS2 -0.0138427450847924 0.856506310673067 -0.0913272811525756 0.135156066352621 miRNAWalker2_validate;miRNATAP -0.130788210838512 0.000420162176279474 NA NA NA hsa-miR-203a-3p RRAS2 -0.393041310603753 0.0191851699904077 -0.0913272811525756 0.135156066352621 MirTarget -0.105486967888788 2.76324948948289e-13 NA NA NA hsa-miR-23b-3p RRAS2 0.0476610245860094 0.630277683372344 -0.0913272811525756 0.135156066352621 MirTarget -0.103571566468602 0.000224509890925739 NA NA NA hsa-miR-29a-3p RRAS2 -0.224140851576083 0.0349516103550236 -0.0913272811525756 0.135156066352621 miRNATAP -0.134719689257944 9.33260365800631e-06 NA NA NA hsa-miR-29c-3p RRAS2 -0.372180390387259 0.00202634431973208 -0.0913272811525756 0.135156066352621 miRNATAP -0.106029728593073 2.49031905730787e-06 NA NA NA hsa-miR-33a-3p RRAS2 -0.158366376619191 0.0991512910387226 -0.0913272811525756 0.135156066352621 MirTarget -0.142838160675966 2.8816901396591e-08 NA NA NA hsa-miR-361-5p RRAS2 0.0107519600643302 0.882230614095565 -0.0913272811525756 0.135156066352621 miRanda -0.181785202212525 1.79177885033938e-05 NA NA NA hsa-miR-381-3p RRAS2 -0.192118086401438 0.203198554750071 -0.0913272811525756 0.135156066352621 MirTarget -0.137522270874508 1.36393568394155e-17 NA NA NA hsa-miR-496 RRAS2 -0.139833482232877 0.39597541862532 -0.0913272811525756 0.135156066352621 miRanda -0.136974714543024 1.42826027377024e-20 NA NA NA hsa-miR-543 RRAS2 -0.347737549779625 0.0157394585079683 -0.0913272811525756 0.135156066352621 miRanda -0.137924656848862 9.23831869425683e-16 NA NA NA hsa-miR-7-5p RRAS2 -0.244254069762734 0.193173919522103 -0.0913272811525756 0.135156066352621 miRNAWalker2_validate;MirTarget;miRNATAP -0.1380263611689 4.59809169654478e-27 NA NA NA hsa-miR-93-5p RRAS2 0.139766237971122 0.101057320076629 -0.0913272811525756 0.135156066352621 miRNAWalker2_validate -0.203144889149896 5.69524711899527e-06 NA NA NA hsa-miR-491-5p SHC1 -0.749881113074983 8.22859263179194e-09 0.358991383839946 6.76993083975626e-09 PITA;miRanda -0.144738840925326 3.22613093526081e-16 NA NA NA hsa-miR-9-5p SHC1 -0.125377971246422 0.269896477802284 0.358991383839946 6.76993083975626e-09 MirTarget;miRNATAP -0.583960378575085 1.89039161963002e-31 NA NA NA hsa-miR-186-5p SHC2 0.0606381894130505 0.514217717592464 -0.157093814295037 0.0281990595568535 miRNAWalker2_validate -0.308195942401308 6.25748897331572e-23 NA NA NA hsa-miR-26a-5p SHC2 0.033823776747294 0.726610414342369 -0.157093814295037 0.0281990595568535 miRNAWalker2_validate -0.217858705592343 1.34512454332448e-10 NA NA NA hsa-let-7a-2-3p SHC3 0.295235553592458 0.00290654476250609 0.199329089069331 0.251218979760753 MirTarget -0.416496269126966 7.02229727025261e-08 NA NA NA hsa-miR-590-5p SHC3 0.16946027035949 0.0386004382081678 0.199329089069331 0.251218979760753 miRanda -0.388942949497297 3.40706336482561e-05 NA NA NA hsa-miR-186-5p SHC4 0.0606381894130505 0.514217717592464 0.136131514690877 0.0573632068776536 MirTarget;mirMAP -0.201704091786307 2.15767475708472e-08 NA NA NA hsa-miR-20a-3p SHC4 0.102743778777997 0.19677865359751 0.136131514690877 0.0573632068776536 miRNATAP -0.14705832284221 0.00015966124508262 NA NA NA hsa-miR-576-5p SHC4 0.106482276040047 0.194379152564166 0.136131514690877 0.0573632068776536 mirMAP -0.174276101469097 3.79172719335206e-06 NA NA NA hsa-miR-15b-5p SHOC2 0.592863156692837 1.41971517354055e-10 -0.140281479846479 0.00449705334582715 MirTarget;miRNATAP -0.139486181786905 1.53586351405494e-13 NA NA NA hsa-miR-30a-5p SHOC2 -0.062942936611238 0.513851954700252 -0.140281479846479 0.00449705334582715 MirTarget;miRNATAP -0.106242355994084 0.000259967806828168 NA NA NA hsa-miR-93-5p SHOC2 0.139766237971122 0.101057320076629 -0.140281479846479 0.00449705334582715 MirTarget;miRNATAP -0.155125355950376 3.76908453162576e-07 NA NA NA hsa-miR-22-5p SOS1 0.0437233965539527 0.639996108995995 0.00523748905885846 0.912745973623718 miRNATAP -0.124027312186166 1.41352250447066e-15 NA NA NA hsa-miR-30a-5p SOS1 -0.062942936611238 0.513851954700252 0.00523748905885846 0.912745973623718 mirMAP;miRNATAP -0.177492800844273 6.3171352970898e-13 NA NA NA hsa-miR-30b-5p SOS1 -0.0858101016322106 0.263243418521854 0.00523748905885846 0.912745973623718 mirMAP -0.16385231555963 4.41286025144966e-13 NA NA NA hsa-miR-30c-2-3p SOS1 -0.18630560418806 0.0313113706136533 0.00523748905885846 0.912745973623718 MirTarget -0.104452765489338 1.12374921832207e-08 NA NA NA hsa-miR-30c-5p SOS1 -0.0469114469943097 0.565934557464627 0.00523748905885846 0.912745973623718 mirMAP;miRNATAP -0.197561323004552 1.3758821302056e-18 NA NA NA hsa-miR-361-5p SOS1 0.0107519600643302 0.882230614095565 0.00523748905885846 0.912745973623718 miRanda -0.115873078362459 3.5425762216149e-06 NA NA NA hsa-miR-365a-3p SOS1 -0.184222766207919 0.0292663235724171 0.00523748905885846 0.912745973623718 miRNATAP -0.149763665687287 4.3259532044635e-18 NA NA NA hsa-miR-664a-3p SOS1 0.0413918462467198 0.611334357897022 0.00523748905885846 0.912745973623718 mirMAP -0.132986198696247 2.29333790618546e-13 NA NA NA hsa-miR-146b-5p SOS2 0.441078059667297 0.000237619929889385 -0.136173831265531 0.0089381592916821 miRanda -0.155137029146937 3.46260583915288e-27 NA NA NA hsa-miR-15a-5p SOS2 0.142658985373611 0.0536219185009004 -0.136173831265531 0.0089381592916821 miRNATAP -0.11015727851104 9.81799896258958e-05 NA NA NA hsa-miR-15b-5p SOS2 0.592863156692837 1.41971517354055e-10 -0.136173831265531 0.0089381592916821 miRNATAP -0.149377221011986 7.33700935351651e-15 NA NA NA hsa-miR-664a-3p SOS2 0.0413918462467198 0.611334357897022 -0.136173831265531 0.0089381592916821 mirMAP -0.18595244526209 1.63522338473879e-18 NA NA NA hsa-miR-9-3p STK4 -0.184945845984695 0.0290051908009009 0.0665699609689918 0.12278898652794 MirTarget;miRNATAP -0.102292280821186 7.36616530731824e-07 NA NA NA hsa-miR-339-5p SYNGAP1 0.273253751377152 0.0185300170790638 -0.215144899341897 0.000642371730267244 PITA;miRNATAP -0.149515850176833 4.19258450753623e-14 NA NA NA hsa-miR-3913-5p SYNGAP1 0.276883251911602 0.00186113779811511 -0.215144899341897 0.000642371730267244 mirMAP -0.101497564574435 0.000116541467959957 NA NA NA hsa-miR-423-5p SYNGAP1 0.0965587900813789 0.148039180704338 -0.215144899341897 0.000642371730267244 PITA -0.109943905842063 0.00565641410967894 NA NA NA hsa-miR-92b-3p SYNGAP1 -0.213968504161963 0.0523921855715716 -0.215144899341897 0.000642371730267244 miRNAWalker2_validate -0.11124786911496 6.52831884852488e-06 NA NA NA hsa-miR-23a-3p TGFA 0.334693010651106 0.00144448147063433 -0.189232317094824 0.055531144411115 miRNATAP -0.217827291086455 2.52845742435621e-06 NA NA NA hsa-miR-452-5p TGFA 0.599327068454211 1.02031931068531e-05 -0.189232317094824 0.055531144411115 mirMAP -0.143183435159408 4.31513936230706e-06 NA NA NA hsa-miR-455-3p TGFA 0.512701816402104 0.000459755983280155 -0.189232317094824 0.055531144411115 miRNATAP -0.13115224083861 8.27073816161446e-06 NA NA NA hsa-miR-576-5p TGFA 0.106482276040047 0.194379152564166 -0.189232317094824 0.055531144411115 mirMAP -0.279355110949944 1.13491350033482e-07 NA NA NA hsa-miR-106a-5p TIAM1 0.110074064773897 0.13045815990621 -0.304574045495384 1.75867608060149e-06 MirTarget;miRNATAP -0.164249842410715 2.96290916362638e-06 NA NA NA hsa-miR-20a-5p TIAM1 -0.0115865752288853 0.887069448776018 -0.304574045495384 1.75867608060149e-06 MirTarget;miRNATAP -0.117353430199072 0.00103280444985757 NA NA NA hsa-miR-320a TIAM1 0.092135599636725 0.243028758989929 -0.304574045495384 1.75867608060149e-06 miRanda;miRNATAP -0.174893944175499 4.95209163556858e-06 NA NA NA hsa-miR-93-5p TIAM1 0.139766237971122 0.101057320076629 -0.304574045495384 1.75867608060149e-06 MirTarget;miRNATAP -0.15478826463135 0.000421367901493947 NA NA NA hsa-miR-101-3p VEGFA -0.132333931567244 0.241891922291381 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate -0.179012476724308 0.000221850261733319 NA NA NA hsa-miR-1224-5p VEGFA -0.53941068839383 0.00201058335769201 0.545202702414815 3.65580722751043e-08 MirTarget -0.12693052777853 1.1909229874546e-07 NA NA NA hsa-miR-129-5p VEGFA -0.567133990117126 0.00116152215679936 0.545202702414815 3.65580722751043e-08 miRanda -0.178350435603243 1.58281485759764e-13 NA NA NA hsa-miR-26b-3p VEGFA -0.0542537787460029 0.4802214385739 0.545202702414815 3.65580722751043e-08 MirTarget -0.151139595719221 0.00815352929658283 NA NA NA hsa-miR-29a-3p VEGFA -0.224140851576083 0.0349516103550236 0.545202702414815 3.65580722751043e-08 MirTarget -0.188400523607611 0.000280773283001581 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29b-2-5p VEGFA -0.26834261955727 0.00453760540520233 0.545202702414815 3.65580722751043e-08 MirTarget -0.238273224497899 1.35712590368669e-07 NA NA NA hsa-miR-29b-3p VEGFA -0.178522712044497 0.0856106432165465 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.174785884873336 0.000121514677714241 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-29c-3p VEGFA -0.372180390387259 0.00202634431973208 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate;MirTarget -0.163350888739243 2.07703033697715e-05 NA NA NA hsa-miR-330-3p VEGFA -0.427388106938151 0.00300489284414266 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate -0.14940180557451 2.38610841931945e-07 NA NA NA hsa-miR-342-3p VEGFA -0.125683829770877 0.105810751640137 0.545202702414815 3.65580722751043e-08 miRanda;miRNATAP -0.183375082823802 0.00268020639799555 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-374b-5p VEGFA -0.210113949579608 0.0056866083818614 0.545202702414815 3.65580722751043e-08 MirTarget -0.259691752964477 3.6506936798186e-05 NA NA NA hsa-miR-383-5p VEGFA -0.850440167826561 1.6745326125383e-07 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.171548247272876 2.39831482676198e-11 NA NA NA hsa-miR-497-5p VEGFA -0.000783764887886562 0.991703566618871 0.545202702414815 3.65580722751043e-08 MirTarget -0.217975385158274 0.000295143152499975 26718330;26485685;26336827;26202364;27015364;25176450;26840372 Furthermore western blot assay confirmed that the overexpression of miR-497 reduced VEGF and HIF-1α protein levels; Moreover miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model which was probably caused by the downregulation of pro-angiogenic molecules such as VEGF and HIF-1α;Role of miR 497 in VEGF A mediated cancer cell growth and invasion in non small cell lung cancer; Here we showed that compared to other cancers NSCLC had a significant higher ratio of VEGF-A protein vs mRNA and significantly lower levels of miR-497 suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers; Compared with paired normal lung tissue NSCLC expressed lower levels of miR-497 and higher levels of VEGF-A; Moreover the levels of miR-497 and VEGF-A were inversely correlated in NSCLC specimen; Bioinformatics analyses showed that miR-497 bound to 3'-UTR of VEGF-A mRNA in NSCLC lines to inhibit its translation; Overexpression of miR-497 in NSCLC lines decreased VEGF-A protein while depletion of miR-497 in NSCLC lines increased VEGF-A protein; However modification of miR-497 levels in NSCLC lines did not alter VEGF-A mRNA levels;MiR 497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG 1; Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions UTRs of vascular endothelial growth factor A VEGFA and astrocyte elevated gene-1 AEG-1;The effects of ectopic miR-497 expression on the expression of VEGFA Akt and p-Akt were determined by western blot; Luciferase reporter assay and western blot confirmed that VEGFA was a direct target of miR-497;Subsequent investigations disclosed that Twist was regulated by miR-497 directly leading to the increased level of Vascular Endothelial Growth Factor-A VEGFA;We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and in turn impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways;Vascular endothelial growth factor-A VEGF-A was confirmed to be a target of miR-497 ;;metastasis;;;; breast cancer;lung squamous cell cancer;liver cancer;sarcoma;pancreatic cancer;ovarian cancer;colorectal cancer hsa-miR-504-5p VEGFA -0.510726779625117 6.12122269907368e-05 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate;miRTarBase -0.212758235683993 1.16548576784258e-10 NA NA NA hsa-miR-9-5p VEGFA -0.125377971246422 0.269896477802284 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate -0.372852027573008 5.51606960459938e-05 NA NA NA hsa-miR-140-5p VEGFB 0.065063507103468 0.380452509211773 -0.0480203658065861 0.445525895152113 miRanda -0.100656379111656 0.00277375404658955 NA NA NA hsa-miR-326 ZAP70 -0.631050656251074 8.83643450601471e-05 0.656941473186731 1.52254397823462e-07 miRanda -0.185256830217027 3.83080920298769e-08 NA NA NA hsa-miR-346 ZAP70 -0.577786425963268 2.10883270131593e-09 0.656941473186731 1.52254397823462e-07 miRanda -0.292475747761757 2.17010470127919e-07 NA NA NA