miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-105-5p AKT2 -0.567459149851677 8.20858944634795e-06 0.139361896216647 0.0151763675439579 mirMAP -0.11517777162873 2.5456118337521e-14 NA NA NA hsa-miR-146b-5p AKT3 0.441078059667297 0.000237619929889385 -0.235109681312394 0.000861339724103604 miRNAWalker2_validate -0.14853390000962 1.54850741316524e-10 NA NA NA hsa-miR-15a-5p AKT3 0.142658985373611 0.0536219185009004 -0.235109681312394 0.000861339724103604 miRNAWalker2_validate;miRTarBase;miRNATAP -0.171093255137198 0.000104922528677221 NA NA NA hsa-miR-15b-5p AKT3 0.592863156692837 1.41971517354055e-10 -0.235109681312394 0.000861339724103604 miRNATAP -0.149023414077877 1.00397425898265e-06 NA NA NA hsa-miR-28-3p AKT3 0.139444423971018 0.0811187936164314 -0.235109681312394 0.000861339724103604 miRNATAP -0.281326919526608 6.94030005162363e-11 NA NA NA hsa-miR-320a AKT3 0.092135599636725 0.243028758989929 -0.235109681312394 0.000861339724103604 PITA;miRanda;miRNATAP -0.162091233103736 0.000150010109497495 NA NA NA hsa-miR-320c AKT3 0.343259124189966 0.000248338401291051 -0.235109681312394 0.000861339724103604 PITA;miRanda;miRNATAP -0.11345587888064 0.000121683825333423 NA NA NA hsa-miR-362-3p AKT3 0.032375035235532 0.736465332563774 -0.235109681312394 0.000861339724103604 miRanda -0.133145359057788 1.93504628679194e-06 NA NA NA hsa-miR-362-5p AKT3 -0.0730185557229279 0.425572997292224 -0.235109681312394 0.000861339724103604 PITA;TargetScan;miRNATAP -0.12269062278053 4.12753291036148e-05 NA NA NA hsa-miR-501-3p AKT3 0.0726267165568464 0.382729320534971 -0.235109681312394 0.000861339724103604 miRNATAP -0.230986821283872 3.52473505159126e-12 NA NA NA hsa-miR-502-3p AKT3 0.0276791089364088 0.697605011368848 -0.235109681312394 0.000861339724103604 miRNATAP -0.217874003496912 1.14360007951059e-08 NA NA NA hsa-miR-93-5p AKT3 0.139766237971122 0.101057320076629 -0.235109681312394 0.000861339724103604 miRNATAP -0.208262975522215 1.91431764461584e-05 NA NA NA hsa-let-7d-5p CBL 0.111345229817909 0.0872634398336815 0.0308635742668164 0.580631538325651 MirTarget -0.169045615496287 1.52200146369667e-06 NA NA NA hsa-miR-140-3p CBL -0.123864258867705 0.14796686619449 0.0308635742668164 0.580631538325651 MirTarget;PITA -0.100847489066595 0.000435462677944787 NA NA NA hsa-miR-19b-3p CBL -0.0138427450847924 0.856506310673067 0.0308635742668164 0.580631538325651 mirMAP -0.116965157518082 2.28035893099693e-05 NA NA NA hsa-miR-342-3p CBL -0.125683829770877 0.105810751640137 0.0308635742668164 0.580631538325651 mirMAP -0.102764274665759 0.000121266209629743 NA NA NA hsa-miR-664a-3p CBL 0.0413918462467198 0.611334357897022 0.0308635742668164 0.580631538325651 mirMAP -0.109274032575653 2.6892538577756e-06 NA NA NA hsa-let-7f-1-3p CBLB 0.110713086694053 0.21484524300518 -0.0670728385065629 0.332908868526974 mirMAP -0.148091130900091 3.01321471136096e-06 NA NA NA hsa-miR-125a-5p CBLB -0.0833349424517387 0.325440200253607 -0.0670728385065629 0.332908868526974 miRanda -0.2904526389221 9.67522504503641e-13 NA NA NA hsa-miR-126-5p CBLB 0.177332403948664 0.0711675116243123 -0.0670728385065629 0.332908868526974 mirMAP -0.183713282601365 9.05488143641059e-10 NA NA NA hsa-miR-146b-5p CBLB 0.441078059667297 0.000237619929889385 -0.0670728385065629 0.332908868526974 miRanda -0.234243636646017 9.63544170660794e-23 NA NA NA hsa-miR-181b-5p CBLB 0.0260899284211646 0.768941836912518 -0.0670728385065629 0.332908868526974 MirTarget;mirMAP -0.106425494768194 0.00812865087404023 NA NA NA hsa-miR-199a-3p CBLB 0.41226331871076 0.000497136154474528 -0.0670728385065629 0.332908868526974 MirTarget;PITA -0.114620691830287 2.22864369127064e-06 NA NA NA hsa-miR-199b-3p CBLB 0.411848361704393 0.000517815011892379 -0.0670728385065629 0.332908868526974 MirTarget;PITA;miRNATAP -0.113943655331748 2.4307587438417e-06 NA NA NA hsa-miR-28-3p CBLB 0.139444423971018 0.0811187936164314 -0.0670728385065629 0.332908868526974 mirMAP -0.22380310016761 1.09873524994333e-06 NA NA NA hsa-miR-29a-5p CBLB -0.0697727833812678 0.350621682973119 -0.0670728385065629 0.332908868526974 MirTarget -0.12468299865 0.00136973725989425 NA NA NA hsa-miR-30a-5p CBLB -0.062942936611238 0.513851954700252 -0.0670728385065629 0.332908868526974 MirTarget -0.445914357287695 2.79575194253035e-21 NA NA NA hsa-miR-30b-5p CBLB -0.0858101016322106 0.263243418521854 -0.0670728385065629 0.332908868526974 MirTarget;mirMAP -0.152236847242553 0.000679325165510735 NA NA NA hsa-miR-30c-5p CBLB -0.0469114469943097 0.565934557464627 -0.0670728385065629 0.332908868526974 MirTarget;mirMAP -0.287178345720521 9.3927924432963e-11 NA NA NA hsa-miR-30d-5p CBLB -0.0607010868720046 0.471410043548794 -0.0670728385065629 0.332908868526974 MirTarget;mirMAP -0.198954843372242 0.000102038589518475 NA NA NA hsa-miR-30e-5p CBLB 0.0764521828640934 0.41904991629622 -0.0670728385065629 0.332908868526974 MirTarget -0.153254933518782 0.000303193366107824 NA NA NA hsa-miR-330-3p CBLB -0.427388106938151 0.00300489284414266 -0.0670728385065629 0.332908868526974 PITA;mirMAP -0.123143851885456 2.07042632909313e-10 NA NA NA hsa-miR-335-3p CBLB 0.34540584335595 0.00043848660222294 -0.0670728385065629 0.332908868526974 mirMAP -0.163226140062683 4.0958355686033e-08 NA NA NA hsa-miR-34c-5p CBLB 0.181931113688093 0.257266965617363 -0.0670728385065629 0.332908868526974 miRanda -0.131449609390242 1.90288090987525e-14 NA NA NA hsa-miR-361-5p CBLB 0.0107519600643302 0.882230614095565 -0.0670728385065629 0.332908868526974 miRanda;mirMAP -0.290636873601637 1.646107492474e-09 NA NA NA hsa-miR-409-3p CBLB 0.00456692516634361 0.974143243758506 -0.0670728385065629 0.332908868526974 mirMAP -0.157795044562728 1.2361898999391e-15 NA NA NA hsa-miR-495-3p CBLB -0.421982588962504 0.00504424038526901 -0.0670728385065629 0.332908868526974 mirMAP -0.143161504063639 1.05763053396881e-14 NA NA NA hsa-miR-543 CBLB -0.347737549779625 0.0157394585079683 -0.0670728385065629 0.332908868526974 miRanda -0.153741051224745 6.42272399383316e-15 NA NA NA hsa-miR-590-3p CBLB 0.312951515438396 0.000480455423843996 -0.0670728385065629 0.332908868526974 miRanda -0.107299604360874 0.000723383036709773 NA NA NA hsa-miR-664a-3p CBLB 0.0413918462467198 0.611334357897022 -0.0670728385065629 0.332908868526974 mirMAP -0.325886035479967 5.53341548497222e-21 NA NA NA hsa-miR-671-5p CBLB 0.379677704170736 0.000129391032677459 -0.0670728385065629 0.332908868526974 PITA -0.257864664826396 5.42377311232518e-21 NA NA NA hsa-let-7e-5p CCND1 0.0471189209570344 0.657255455444655 0.517304800763483 1.04046594178888e-06 miRTarBase;miRNATAP -0.228941875441154 1.78800254985128e-06 NA NA NA hsa-let-7i-5p CCND1 0.0952853587923244 0.192120688957249 0.517304800763483 1.04046594178888e-06 miRNATAP -0.236343082962889 0.00183350614645 NA NA NA hsa-miR-1266-5p CCND1 0.313515127917259 0.0138664194727392 0.517304800763483 1.04046594178888e-06 MirTarget -0.112027246009442 0.00108554865163972 NA NA NA hsa-miR-135a-5p CCND1 -0.122734612943241 0.196985964641886 0.517304800763483 1.04046594178888e-06 mirMAP -0.247492714890572 1.3238406350361e-07 NA NA NA hsa-miR-23b-3p CCND1 0.0476610245860094 0.630277683372344 0.517304800763483 1.04046594178888e-06 miRNATAP -0.279243855267394 9.57342364736838e-09 NA NA NA hsa-miR-26b-5p CCND1 -0.0984536538762768 0.231803769574623 0.517304800763483 1.04046594178888e-06 miRNAWalker2_validate -0.171067179820866 0.00692173397836684 NA NA NA hsa-miR-29a-3p CCND1 -0.224140851576083 0.0349516103550236 0.517304800763483 1.04046594178888e-06 mirMAP -0.23358540897967 1.12603356998685e-05 NA NA NA hsa-miR-29b-3p CCND1 -0.178522712044497 0.0856106432165465 0.517304800763483 1.04046594178888e-06 mirMAP -0.30608004962895 3.25721913642118e-11 NA NA NA hsa-miR-29c-3p CCND1 -0.372180390387259 0.00202634431973208 0.517304800763483 1.04046594178888e-06 mirMAP -0.263497298429692 1.34805822955252e-11 NA NA NA hsa-miR-3065-5p CCND1 -0.262608140481507 0.0414570974148034 0.517304800763483 1.04046594178888e-06 mirMAP -0.105747126080182 0.00178155205723976 NA NA NA hsa-miR-330-3p CCND1 -0.427388106938151 0.00300489284414266 0.517304800763483 1.04046594178888e-06 mirMAP -0.156757729272097 1.33987981854083e-07 NA NA NA hsa-miR-338-3p CCND1 -0.39963704679384 0.0034410643220691 0.517304800763483 1.04046594178888e-06 miRNAWalker2_validate;miRTarBase;miRanda -0.138060683824931 7.24806702911648e-05 NA NA NA hsa-miR-34a-5p CCND1 0.143472919835524 0.211283228567057 0.517304800763483 1.04046594178888e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.176667405034615 4.78965946188406e-06 25792709;21399894 This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a ; liver cancer;breast cancer hsa-miR-365a-3p CCND1 -0.184222766207919 0.0292663235724171 0.517304800763483 1.04046594178888e-06 miRNAWalker2_validate;miRTarBase -0.195991913128339 0.000198680829195249 NA NA NA hsa-miR-425-5p CCND1 -0.0412837711174561 0.682284485592858 0.517304800763483 1.04046594178888e-06 miRNAWalker2_validate -0.134644465621285 0.00325561137510874 NA NA NA hsa-miR-490-3p CCND1 -0.834268051506884 5.26203010743215e-06 0.517304800763483 1.04046594178888e-06 miRanda -0.131117175699242 2.90415525218072e-08 24440705 MicroRNA 490 3p inhibits proliferation of A549 lung cancer cells by targeting CCND1; We also found that forced expression of miR-490-3P decreased both mRNA and protein levels of CCND1 which plays a key role in G1/S phase transition; In addition the dual-luciferase reporter assays indicated that miR-490-3P directly targets CCND1 through binding its 3'UTR lung cancer hsa-miR-495-3p CCND1 -0.421982588962504 0.00504424038526901 0.517304800763483 1.04046594178888e-06 MirTarget -0.136090131725584 2.1911780731285e-06 NA NA NA hsa-miR-7-1-3p CCND1 -0.0894475316162393 0.37322359785108 0.517304800763483 1.04046594178888e-06 mirMAP -0.241924898170475 2.08913227927897e-08 NA NA NA hsa-miR-769-3p CCND1 -0.287263649023213 0.018145224330845 0.517304800763483 1.04046594178888e-06 mirMAP -0.276564457533319 1.97356475814615e-15 NA NA NA hsa-miR-885-5p CCND1 -0.423614695846868 1.14213289528402e-05 0.517304800763483 1.04046594178888e-06 miRNATAP -0.292419966156513 1.08197956283879e-10 NA NA NA hsa-let-7b-3p CCND2 -0.00495618733298731 0.952288980686967 0.278072058804804 0.00230941164668614 mirMAP -0.124812140552693 0.00599796857804289 NA NA NA hsa-let-7f-1-3p CCND2 0.110713086694053 0.21484524300518 0.278072058804804 0.00230941164668614 mirMAP -0.122537465829283 0.00233902672067921 NA NA NA hsa-let-7g-5p CCND2 -0.0253396334608382 0.742556489443668 0.278072058804804 0.00230941164668614 miRNATAP -0.196434601966773 0.0012996932102575 NA NA NA hsa-let-7i-5p CCND2 0.0952853587923244 0.192120688957249 0.278072058804804 0.00230941164668614 miRNATAP -0.162156277541767 0.00988534673137717 NA NA NA hsa-miR-129-5p CCND2 -0.567133990117126 0.00116152215679936 0.278072058804804 0.00230941164668614 mirMAP -0.105272286982926 4.44505393807218e-07 NA NA NA hsa-miR-145-3p CCND2 0.110543172922298 0.294150620210019 0.278072058804804 0.00230941164668614 mirMAP -0.149944712694934 9.82587587919985e-06 NA NA NA hsa-miR-145-5p CCND2 0.108948399943015 0.310032352776693 0.278072058804804 0.00230941164668614 miRNATAP -0.155654659327631 1.04593167784463e-05 NA NA NA hsa-miR-146b-3p CCND2 0.283486177568242 0.0118918188864879 0.278072058804804 0.00230941164668614 MirTarget;PITA;miRNATAP -0.117766891479947 0.000283548163350027 NA NA NA hsa-miR-150-5p CCND2 0.0645271721519611 0.513295658828718 0.278072058804804 0.00230941164668614 mirMAP -0.149451068560082 7.57763104304709e-05 NA NA NA hsa-miR-151a-3p CCND2 0.0336074122085215 0.726834677736803 0.278072058804804 0.00230941164668614 mirMAP -0.12420907434582 0.00497911559673839 NA NA NA hsa-miR-185-5p CCND2 -0.0767432095218297 0.404113540276816 0.278072058804804 0.00230941164668614 MirTarget;miRNATAP -0.183398276514872 8.3630357382723e-06 NA NA NA hsa-miR-186-5p CCND2 0.0606381894130505 0.514217717592464 0.278072058804804 0.00230941164668614 mirMAP;miRNATAP -0.133720175872038 0.00173369326890833 NA NA NA hsa-miR-191-5p CCND2 0.0973986771912738 0.220078671774056 0.278072058804804 0.00230941164668614 MirTarget -0.20451499794437 0.00023723661594718 NA NA NA hsa-miR-26a-5p CCND2 0.033823776747294 0.726610414342369 0.278072058804804 0.00230941164668614 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.122521188171157 0.00669669430395561 NA NA NA hsa-miR-26b-5p CCND2 -0.0984536538762768 0.231803769574623 0.278072058804804 0.00230941164668614 mirMAP;miRNATAP -0.21765809461179 3.01296451472833e-05 NA NA NA hsa-miR-28-5p CCND2 0.104003572105781 0.153594705579534 0.278072058804804 0.00230941164668614 miRanda -0.151040812510917 0.00458703218164268 NA NA NA hsa-miR-29a-3p CCND2 -0.224140851576083 0.0349516103550236 0.278072058804804 0.00230941164668614 MirTarget;miRNATAP -0.199711571525784 5.61968185759315e-06 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-29a-5p CCND2 -0.0697727833812678 0.350621682973119 0.278072058804804 0.00230941164668614 mirMAP -0.166759307844904 0.000688470083956136 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-29b-3p CCND2 -0.178522712044497 0.0856106432165465 0.278072058804804 0.00230941164668614 MirTarget;miRNATAP -0.202303651104096 1.45292987304036e-07 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-29c-3p CCND2 -0.372180390387259 0.00202634431973208 0.278072058804804 0.00230941164668614 MirTarget;miRNATAP -0.239386359038839 8.64180673949139e-14 NA NA NA hsa-miR-30d-3p CCND2 0.0854049347792898 0.20691254801121 0.278072058804804 0.00230941164668614 mirMAP -0.155355754639963 0.00382748112364014 NA NA NA hsa-miR-30e-3p CCND2 0.00173769765874887 0.984965501547409 0.278072058804804 0.00230941164668614 mirMAP -0.268522462794922 4.02496537819957e-07 NA NA NA hsa-miR-324-3p CCND2 -0.0103367134443655 0.904494071318044 0.278072058804804 0.00230941164668614 miRNAWalker2_validate -0.184828101121747 1.93642919504512e-05 NA NA NA hsa-miR-331-5p CCND2 0.00538076980695534 0.942833685963252 0.278072058804804 0.00230941164668614 miRNATAP -0.168360380366874 0.000470859110297375 NA NA NA hsa-miR-33a-3p CCND2 -0.158366376619191 0.0991512910387226 0.278072058804804 0.00230941164668614 MirTarget -0.10197096016646 0.00681801603426165 NA NA NA hsa-miR-3622a-3p CCND2 0.0389203848593471 0.75605812962459 0.278072058804804 0.00230941164668614 mirMAP -0.125163354365051 1.78891207109425e-05 NA NA NA hsa-miR-488-3p CCND2 -0.257955761012568 0.00280795162806256 0.278072058804804 0.00230941164668614 mirMAP -0.183392273105331 1.52514393662224e-05 NA NA NA hsa-miR-488-5p CCND2 -0.385755602369049 7.99431673275965e-08 0.278072058804804 0.00230941164668614 mirMAP -0.153852506035559 0.00315722783501446 NA NA NA hsa-miR-500a-5p CCND2 0.0634452729978863 0.396072382601677 0.278072058804804 0.00230941164668614 mirMAP -0.155381019814906 0.0013241335866013 NA NA NA hsa-miR-501-5p CCND2 0.0878951859817452 0.309663377222443 0.278072058804804 0.00230941164668614 PITA;mirMAP;miRNATAP -0.110941849752897 0.00801840144207187 NA NA NA hsa-miR-660-5p CCND2 -0.138989893523975 0.0945491063873448 0.278072058804804 0.00230941164668614 mirMAP -0.238701834193771 2.94573193719288e-07 NA NA NA hsa-miR-7-1-3p CCND2 -0.0894475316162393 0.37322359785108 0.278072058804804 0.00230941164668614 mirMAP -0.150925481137646 2.69591030726187e-05 NA NA NA hsa-miR-491-5p CLCF1 -0.749881113074983 8.22859263179194e-09 0.977820939344929 2.821033339493e-12 miRanda -0.286838422195321 7.23876413812648e-10 NA NA NA hsa-miR-146b-5p CNTFR 0.441078059667297 0.000237619929889385 -0.301957438565181 0.00501495799877331 miRNATAP -0.252293776331491 1.20552998278622e-10 NA NA NA hsa-miR-193a-5p CNTFR 0.183172152450491 0.0749251910521214 -0.301957438565181 0.00501495799877331 TargetScan;miRNATAP -0.389865109853025 1.39571418351396e-18 NA NA NA hsa-miR-1976 CNTFR 0.127074435034705 0.277235601775457 -0.301957438565181 0.00501495799877331 miRNATAP -0.323186642573695 8.53083309215917e-18 NA NA NA hsa-miR-19a-3p CNTFR 0.0466707843731911 0.576818938277755 -0.301957438565181 0.00501495799877331 miRNATAP -0.196515146611566 0.000582484021346595 NA NA NA hsa-miR-19b-3p CNTFR -0.0138427450847924 0.856506310673067 -0.301957438565181 0.00501495799877331 miRNATAP -0.205570339865686 0.0025703312792556 NA NA NA hsa-miR-200b-3p CNTFR 0.245768526504511 0.0580744465744737 -0.301957438565181 0.00501495799877331 TargetScan -0.193665808086505 4.85620078910108e-08 NA NA NA hsa-miR-200c-3p CNTFR 0.413752622631695 8.6936333715621e-06 -0.301957438565181 0.00501495799877331 miRNATAP -0.428836224324301 1.08612084529287e-19 NA NA NA hsa-miR-21-5p CNTFR 1.0504925175311 2.58081295984106e-11 -0.301957438565181 0.00501495799877331 miRNATAP -0.418753974590567 9.00749399229567e-45 NA NA NA hsa-miR-24-3p CNTFR 0.133257261462871 0.212960921400853 -0.301957438565181 0.00501495799877331 miRNATAP -0.332557186804594 7.94836334914143e-13 NA NA NA hsa-miR-26b-5p CNTFR -0.0984536538762768 0.231803769574623 -0.301957438565181 0.00501495799877331 miRNAWalker2_validate -0.271594674343332 4.04658856542787e-05 NA NA NA hsa-miR-27b-5p CNTFR 0.224282840351546 0.00630787296051719 -0.301957438565181 0.00501495799877331 miRNATAP -0.445223876636019 2.18816110855416e-16 NA NA NA hsa-miR-28-5p CNTFR 0.104003572105781 0.153594705579534 -0.301957438565181 0.00501495799877331 PITA;miRanda;miRNATAP -0.473374066155585 8.64533001304028e-13 NA NA NA hsa-miR-296-5p CNTFR -0.0192165981442809 0.870822664524408 -0.301957438565181 0.00501495799877331 PITA;miRNATAP -0.173708220198066 6.43154887457387e-06 NA NA NA hsa-miR-361-3p CNTFR -0.0798653643614555 0.271064714084553 -0.301957438565181 0.00501495799877331 PITA;miRNATAP -0.254495299288132 0.000410791949957939 NA NA NA hsa-miR-484 CNTFR -0.0190828819137732 0.802298900989652 -0.301957438565181 0.00501495799877331 PITA;miRNATAP -0.389283160089396 8.52624472271801e-10 NA NA NA hsa-miR-589-5p CNTFR -0.0382528919634639 0.5844074434222 -0.301957438565181 0.00501495799877331 miRNATAP -0.342860538666287 5.70800243475719e-06 NA NA NA hsa-miR-590-5p CNTFR 0.16946027035949 0.0386004382081678 -0.301957438565181 0.00501495799877331 PITA;miRanda;miRNATAP -0.428701505053388 6.42765953199238e-15 NA NA NA hsa-miR-708-5p CNTFR -0.00936519718301376 0.919857671524527 -0.301957438565181 0.00501495799877331 miRNATAP -0.239265884241998 7.0133365763493e-06 NA NA NA hsa-let-7e-5p CREBBP 0.0471189209570344 0.657255455444655 -0.047978601693571 0.404366818323115 miRNAWalker2_validate -0.117826371466181 2.40828040481683e-09 NA NA NA hsa-miR-1301-3p CREBBP -0.105695714210758 0.152249184194132 -0.047978601693571 0.404366818323115 miRNAWalker2_validate -0.145041633909724 7.95662975669671e-09 NA NA NA hsa-miR-142-5p CREBBP 0.434884875454107 0.000575570345702788 -0.047978601693571 0.404366818323115 mirMAP -0.106025113337559 1.85000672571322e-14 NA NA NA hsa-miR-186-5p CREBBP 0.0606381894130505 0.514217717592464 -0.047978601693571 0.404366818323115 mirMAP;miRNATAP -0.147890785462563 1.79437968717686e-12 NA NA NA hsa-miR-200b-3p CREBBP 0.245768526504511 0.0580744465744737 -0.047978601693571 0.404366818323115 mirMAP -0.123048999824309 2.44260177280472e-19 NA NA NA hsa-miR-200c-3p CREBBP 0.413752622631695 8.6936333715621e-06 -0.047978601693571 0.404366818323115 mirMAP -0.133825633175237 1.58816104033339e-12 NA NA NA hsa-miR-26a-5p CREBBP 0.033823776747294 0.726610414342369 -0.047978601693571 0.404366818323115 miRNATAP -0.116054995750247 2.26207553528174e-07 NA NA NA hsa-miR-26b-5p CREBBP -0.0984536538762768 0.231803769574623 -0.047978601693571 0.404366818323115 miRNATAP -0.164373734995276 2.00260444141814e-10 NA NA NA hsa-miR-30a-3p CREBBP 0.0655410309550977 0.509541256241954 -0.047978601693571 0.404366818323115 MirTarget;miRNATAP -0.118406533193908 4.53827599405547e-07 NA NA NA hsa-miR-30e-3p CREBBP 0.00173769765874887 0.984965501547409 -0.047978601693571 0.404366818323115 MirTarget -0.140461173361411 1.16147592773995e-07 NA NA NA hsa-miR-361-5p CREBBP 0.0107519600643302 0.882230614095565 -0.047978601693571 0.404366818323115 PITA;miRanda;miRNATAP -0.20977112720493 4.42799460550161e-12 NA NA NA hsa-miR-374a-3p CREBBP 0.176226170437625 0.0343958848425446 -0.047978601693571 0.404366818323115 miRNATAP -0.166006934673094 4.57407449473457e-10 NA NA NA hsa-miR-548b-3p CREBBP 0.340474544210108 0.00224491592019745 -0.047978601693571 0.404366818323115 miRNATAP -0.122339265277455 1.92040117401605e-14 NA NA NA hsa-miR-590-3p CREBBP 0.312951515438396 0.000480455423843996 -0.047978601693571 0.404366818323115 PITA;miRanda;mirMAP;miRNATAP -0.145167352998136 1.52352483162506e-13 NA NA NA hsa-miR-628-3p CREBBP -0.243661425878074 0.0594758496279051 -0.047978601693571 0.404366818323115 PITA -0.103726817505493 6.28819709328743e-14 NA NA NA hsa-miR-1179 CSF2RB -0.117056451908751 0.310989525634765 0.358164957553302 0.00109646465284101 MirTarget -0.277142305322641 4.27158635401549e-11 NA NA NA hsa-miR-137 CSF2RB -0.924849266740909 1.546832202049e-06 0.358164957553302 0.00109646465284101 miRanda -0.155502720489839 1.5055922861964e-10 NA NA NA hsa-miR-542-3p CSF3 0.0835995677900829 0.403838744494071 -0.143662984860303 0.461317655012971 miRanda -0.302218089112359 0.00130823318349244 NA NA NA hsa-miR-138-5p CSF3R -0.616087649920851 1.35200027885729e-05 0.172703978715942 0.111444824636693 MirTarget -0.139153549859984 2.30931003852574e-05 NA NA NA hsa-miR-149-5p EP300 -0.0535821592029952 0.657713892012548 -0.0809024456519438 0.228129652996621 miRNAWalker2_validate -0.118369420853507 3.40308138671425e-09 NA NA NA hsa-miR-186-5p EP300 0.0606381894130505 0.514217717592464 -0.0809024456519438 0.228129652996621 miRNATAP -0.120697160730751 2.08389735806641e-05 NA NA NA hsa-miR-200b-3p EP300 0.245768526504511 0.0580744465744737 -0.0809024456519438 0.228129652996621 miRNAWalker2_validate;TargetScan -0.113063865997244 1.22732110177343e-09 NA NA NA hsa-miR-200c-3p EP300 0.413752622631695 8.6936333715621e-06 -0.0809024456519438 0.228129652996621 miRNAWalker2_validate;miRNATAP -0.154403328800266 1.16945030241261e-09 NA NA NA hsa-miR-22-3p EP300 0.0277287593466351 0.809325106832648 -0.0809024456519438 0.228129652996621 MirTarget;miRNATAP -0.129040932214718 7.43865109883095e-06 NA NA NA hsa-miR-2355-3p EP300 0.186207523505296 0.0525918026993012 -0.0809024456519438 0.228129652996621 MirTarget;miRNATAP -0.10892387366383 1.09126064579299e-05 NA NA NA hsa-miR-26b-5p EP300 -0.0984536538762768 0.231803769574623 -0.0809024456519438 0.228129652996621 miRNAWalker2_validate;miRNATAP -0.146408928599053 2.57076047853747e-05 NA NA NA hsa-miR-29b-1-5p EP300 0.191335428755774 0.00846436454790702 -0.0809024456519438 0.228129652996621 MirTarget -0.110260412848281 0.000822430640380143 NA NA NA hsa-miR-30c-5p EP300 -0.0469114469943097 0.565934557464627 -0.0809024456519438 0.228129652996621 miRNAWalker2_validate -0.312468973887759 2.06637782937568e-17 NA NA NA hsa-miR-339-5p EP300 0.273253751377152 0.0185300170790638 -0.0809024456519438 0.228129652996621 miRanda -0.139872022902314 5.63823302029633e-12 NA NA NA hsa-miR-342-3p EP300 -0.125683829770877 0.105810751640137 -0.0809024456519438 0.228129652996621 MirTarget;PITA;miRanda;miRNATAP -0.186971239869884 5.16619501373405e-08 NA NA NA hsa-miR-361-3p EP300 -0.0798653643614555 0.271064714084553 -0.0809024456519438 0.228129652996621 PITA -0.179432283394391 1.94960435203698e-06 NA NA NA hsa-miR-574-3p EP300 0.254057161073935 0.0219522676746007 -0.0809024456519438 0.228129652996621 PITA -0.118613580916583 3.76846499771262e-08 NA NA NA hsa-miR-590-3p EP300 0.312951515438396 0.000480455423843996 -0.0809024456519438 0.228129652996621 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.112448802446131 2.42909707997915e-05 NA NA NA hsa-miR-127-3p EPOR -0.164565333886312 0.2710118155902 0.0411495540224545 0.503972859095025 miRanda -0.104745571126651 6.12644572107856e-09 NA NA NA hsa-miR-15a-5p GHR 0.142658985373611 0.0536219185009004 -0.170267272957687 0.064035899095635 MirTarget;miRNATAP -0.283525052226473 1.23937238408672e-05 NA NA NA hsa-miR-15b-5p GHR 0.592863156692837 1.41971517354055e-10 -0.170267272957687 0.064035899095635 MirTarget;miRNATAP -0.167949477261025 0.000197060848540285 NA NA NA hsa-miR-16-5p GHR 0.246024668671282 0.00346042804503716 -0.170267272957687 0.064035899095635 MirTarget;miRNATAP -0.219309642371149 8.32214570465822e-05 NA NA NA hsa-miR-186-5p IFNAR1 0.0606381894130505 0.514217717592464 0.0815555266823358 0.085186300841266 mirMAP -0.118345955693356 3.03240827542331e-13 NA NA NA hsa-miR-342-3p IFNAR2 -0.125683829770877 0.105810751640137 0.224904507866693 1.10783968925471e-06 miRanda -0.120674763875099 7.96590361266096e-07 NA NA NA hsa-miR-491-5p IFNAR2 -0.749881113074983 8.22859263179194e-09 0.224904507866693 1.10783968925471e-06 miRanda -0.11148417642644 2.51011244890288e-19 NA NA NA hsa-miR-496 IL10 -0.139833482232877 0.39597541862532 0.663546761682282 1.14057359012358e-05 miRanda -0.146107325527839 0.000355063908254408 NA NA NA hsa-miR-543 IL10 -0.347737549779625 0.0157394585079683 0.663546761682282 1.14057359012358e-05 PITA;miRanda;miRNATAP -0.146623974752124 0.00191372014797953 NA NA NA hsa-miR-769-5p IL10 -0.320572895263071 0.00425481410304398 0.663546761682282 1.14057359012358e-05 miRNATAP -0.161546560502848 0.00790031927038623 NA NA NA hsa-miR-129-2-3p IL10RA -0.6175132197013 0.000561573620904867 0.285399445624507 0.00749828276793137 mirMAP -0.139247538140941 3.31795272423232e-08 NA NA NA hsa-miR-129-5p IL10RB -0.567133990117126 0.00116152215679936 0.316836032421493 4.1181024991389e-10 miRanda -0.133256973023588 2.90326338463969e-34 NA NA NA hsa-miR-3607-3p IL11 -0.0118040987013632 0.907228689257085 0.0208142890167515 0.849025785258516 MirTarget -0.168817275864588 0.000381511235093357 NA NA NA hsa-miR-193a-3p IL11RA 0.395602305834739 0.00182611787714301 -0.0969525266118936 0.300617257013242 miRanda -0.114483596271012 0.000351137547112748 NA NA NA hsa-miR-21-5p IL12A 1.0504925175311 2.58081295984106e-11 -0.214937360433277 0.0339831648305032 MirTarget -0.14779928812961 2.62305046009305e-06 NA NA NA hsa-miR-128-3p IL13RA1 -0.781932174412672 7.1812756321342e-10 0.233331210934852 0.0115821447985142 MirTarget -0.14997916924187 3.55162975265756e-06 NA NA NA hsa-miR-181a-2-3p IL13RA1 -0.0630409614874416 0.473088318215936 0.233331210934852 0.0115821447985142 MirTarget -0.193445840989602 0.00152854459114883 NA NA NA hsa-miR-129-5p IL15 -0.567133990117126 0.00116152215679936 0.548696352183111 3.05512781066991e-05 miRanda -0.11824762489829 0.000455487507844168 NA NA NA hsa-miR-139-5p IL15 -0.647754756897633 2.15378307237163e-06 0.548696352183111 3.05512781066991e-05 miRanda -0.229020067896396 1.10469871548934e-07 NA NA NA hsa-miR-346 IL15 -0.577786425963268 2.10883270131593e-09 0.548696352183111 3.05512781066991e-05 miRanda -0.291029520996775 8.21701569497684e-07 NA NA NA hsa-miR-484 IL20RB -0.0190828819137732 0.802298900989652 0.0723104365953893 0.360085232276365 miRNATAP -0.170972679626479 0.00043762273714803 NA NA NA hsa-miR-421 IL21R -0.171573235029879 0.0518112933651029 0.341787584967233 0.0743923083509994 miRanda -0.270120074561093 0.00476392255478508 NA NA NA hsa-miR-127-3p IL2RA -0.164565333886312 0.2710118155902 1.05702792804828 2.61283859117689e-07 miRanda -0.211375849076243 0.000859719069504647 NA NA NA hsa-miR-139-5p IL2RB -0.647754756897633 2.15378307237163e-06 1.00440373639227 5.18213761407867e-11 miRanda -0.351231095583441 3.32986568961996e-12 NA NA NA hsa-miR-30b-3p IL2RB -0.127948682481846 0.0864252098996846 1.00440373639227 5.18213761407867e-11 mirMAP -0.292902711413923 0.00142711396240077 NA NA NA hsa-miR-491-5p IL2RG -0.749881113074983 8.22859263179194e-09 0.671166889826602 2.23955811529298e-08 miRanda -0.17634830211617 1.01369044880547e-05 NA NA NA hsa-miR-139-5p IL6 -0.647754756897633 2.15378307237163e-06 0.860210379772624 5.71029329538237e-06 miRanda -0.193255461876079 0.00224121799463508 NA NA NA hsa-miR-20a-5p IL6R -0.0115865752288853 0.887069448776018 0.0770823555036904 0.433223467256896 mirMAP -0.30663750063624 7.91033715433322e-07 NA NA NA hsa-miR-454-3p IL6R 0.177318549827649 0.0120865170334418 0.0770823555036904 0.433223467256896 mirMAP -0.209354727979356 0.000832523423811704 NA NA NA hsa-let-7a-3p IL6ST 0.0530563276543763 0.370749834463566 -0.00268212361004228 0.984821649421786 mirMAP -0.374624311046102 0.00099632901023853 NA NA NA hsa-miR-135a-5p IL6ST -0.122734612943241 0.196985964641886 -0.00268212361004228 0.984821649421786 mirMAP;miRNATAP -0.257226466229029 8.33162249057739e-05 NA NA NA hsa-miR-19a-3p IL6ST 0.0466707843731911 0.576818938277755 -0.00268212361004228 0.984821649421786 mirMAP;miRNATAP -0.302151680181405 5.97541669637287e-05 NA NA NA hsa-miR-19b-3p IL6ST -0.0138427450847924 0.856506310673067 -0.00268212361004228 0.984821649421786 mirMAP;miRNATAP -0.389984695843643 1.34662506139268e-05 NA NA NA hsa-miR-30b-5p IL6ST -0.0858101016322106 0.263243418521854 -0.00268212361004228 0.984821649421786 mirMAP -0.296351344390988 0.0017621683135217 NA NA NA hsa-miR-30c-5p IL6ST -0.0469114469943097 0.565934557464627 -0.00268212361004228 0.984821649421786 mirMAP -0.351154052606623 0.000217311435202278 NA NA NA hsa-miR-362-5p IL6ST -0.0730185557229279 0.425572997292224 -0.00268212361004228 0.984821649421786 mirMAP -0.474170994884088 4.96071913230737e-13 NA NA NA hsa-miR-454-3p IL6ST 0.177318549827649 0.0120865170334418 -0.00268212361004228 0.984821649421786 mirMAP;miRNATAP -0.384567028960689 1.43347732645582e-05 NA NA NA hsa-miR-9-3p IL6ST -0.184945845984695 0.0290051908009009 -0.00268212361004228 0.984821649421786 mirMAP;miRNATAP -0.437678214777378 5.42253819959795e-06 NA NA NA hsa-miR-129-5p IL7 -0.567133990117126 0.00116152215679936 0.684293010681995 9.78223559554558e-10 miRanda -0.107243044709145 0.00020186000418907 NA NA NA hsa-miR-338-5p IL7 -0.424003687569629 0.00246415720301323 0.684293010681995 9.78223559554558e-10 mirMAP -0.128084950134086 0.000321798570969427 NA NA NA hsa-miR-374b-5p IL7 -0.210113949579608 0.0056866083818614 0.684293010681995 9.78223559554558e-10 mirMAP -0.260518576286309 0.000418151140098164 NA NA NA hsa-miR-106a-5p JAK1 0.110074064773897 0.13045815990621 -0.0503084531769042 0.44032587078483 MirTarget -0.12488961834165 9.2385632187374e-05 NA NA NA hsa-miR-15b-5p JAK1 0.592863156692837 1.41971517354055e-10 -0.0503084531769042 0.44032587078483 miRNAWalker2_validate -0.106224276481482 1.94553224451923e-05 NA NA NA hsa-miR-20a-5p JAK1 -0.0115865752288853 0.887069448776018 -0.0503084531769042 0.44032587078483 MirTarget -0.134393265011369 3.17535444634639e-05 NA NA NA hsa-miR-30b-5p JAK1 -0.0858101016322106 0.263243418521854 -0.0503084531769042 0.44032587078483 MirTarget -0.107920848850336 0.00180958066794483 NA NA NA hsa-let-7a-3p JAK2 0.0530563276543763 0.370749834463566 0.0814742590745103 0.105857224086 mirMAP;miRNATAP -0.140581575924282 0.000229649587953778 NA NA NA hsa-miR-320a LEPR 0.092135599636725 0.243028758989929 -0.00582288815541254 0.941838370234207 miRanda -0.230575749051878 1.52453305532587e-05 NA NA NA hsa-miR-124-3p LIF -0.506026514549291 0.0078056370358648 1.17272538294773 4.15767685203862e-12 MirTarget -0.234612952099488 2.75100083328934e-09 NA NA NA hsa-miR-129-2-3p LIF -0.6175132197013 0.000561573620904867 1.17272538294773 4.15767685203862e-12 mirMAP -0.347670520060091 1.91316856416146e-17 NA NA NA hsa-miR-181a-5p LIF -0.178215604431845 0.0700010802255601 1.17272538294773 4.15767685203862e-12 miRNATAP -0.360325283780028 0.000638239789387495 NA NA NA hsa-miR-338-5p LIF -0.424003687569629 0.00246415720301323 1.17272538294773 4.15767685203862e-12 mirMAP -0.240981711426042 9.17332380712418e-06 NA NA NA hsa-miR-346 LIF -0.577786425963268 2.10883270131593e-09 1.17272538294773 4.15767685203862e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.570165356071126 7.28968311395183e-14 NA NA NA hsa-miR-577 LIF -0.382068371859275 0.0145513192729119 1.17272538294773 4.15767685203862e-12 mirMAP -0.183467407653406 0.000166102958668467 NA NA NA hsa-miR-769-5p LIF -0.320572895263071 0.00425481410304398 1.17272538294773 4.15767685203862e-12 miRNATAP -0.279413370904597 4.91740760905136e-05 NA NA NA hsa-let-7a-3p LIFR 0.0530563276543763 0.370749834463566 -0.385582205083604 2.53026450447379e-05 mirMAP -0.199506966581809 0.00276908613061351 NA NA NA hsa-let-7f-1-3p LIFR 0.110713086694053 0.21484524300518 -0.385582205083604 2.53026450447379e-05 mirMAP -0.162655038919302 3.50129635309124e-05 NA NA NA hsa-miR-126-5p LIFR 0.177332403948664 0.0711675116243123 -0.385582205083604 2.53026450447379e-05 mirMAP -0.10859182884099 0.00388548550446432 NA NA NA hsa-miR-130a-5p LIFR 0.155569168973665 0.0884246261384798 -0.385582205083604 2.53026450447379e-05 mirMAP -0.114550190713454 0.00350364292869944 NA NA NA hsa-miR-136-5p LIFR -0.0792119620142504 0.581591369035763 -0.385582205083604 2.53026450447379e-05 mirMAP;miRNATAP -0.103278753355886 2.91984509318724e-05 NA NA NA hsa-miR-19a-3p LIFR 0.0466707843731911 0.576818938277755 -0.385582205083604 2.53026450447379e-05 mirMAP -0.212811227773305 1.25357926863615e-06 NA NA NA hsa-miR-19b-3p LIFR -0.0138427450847924 0.856506310673067 -0.385582205083604 2.53026450447379e-05 mirMAP -0.273509270622511 1.63841383914928e-07 NA NA NA hsa-miR-21-5p LIFR 1.0504925175311 2.58081295984106e-11 -0.385582205083604 2.53026450447379e-05 miRNAWalker2_validate -0.132291774046052 1.09714642870804e-07 NA NA NA hsa-miR-222-3p LIFR 0.107117065575197 0.423818119725697 -0.385582205083604 2.53026450447379e-05 miRNATAP -0.111221145495216 2.04116097716662e-05 NA NA NA hsa-miR-335-3p LIFR 0.34540584335595 0.00043848660222294 -0.385582205083604 2.53026450447379e-05 MirTarget -0.155298312501796 2.71658131684861e-05 NA NA NA hsa-miR-409-3p LIFR 0.00456692516634361 0.974143243758506 -0.385582205083604 2.53026450447379e-05 mirMAP -0.138931364682343 2.0305624156015e-08 NA NA NA hsa-miR-548b-3p LIFR 0.340474544210108 0.00224491592019745 -0.385582205083604 2.53026450447379e-05 miRNATAP -0.157295405886048 7.40694943609537e-07 NA NA NA hsa-miR-590-3p LIFR 0.312951515438396 0.000480455423843996 -0.385582205083604 2.53026450447379e-05 miRanda;mirMAP -0.106742823300001 0.006647296373209 NA NA NA hsa-miR-664a-3p LIFR 0.0413918462467198 0.611334357897022 -0.385582205083604 2.53026450447379e-05 mirMAP -0.152297819065573 0.000612746988103486 NA NA NA hsa-miR-7-1-3p LIFR -0.0894475316162393 0.37322359785108 -0.385582205083604 2.53026450447379e-05 mirMAP -0.136746718899277 0.000105909394251629 NA NA NA hsa-miR-940 LIFR -0.0183807673806575 0.881747775878136 -0.385582205083604 2.53026450447379e-05 MirTarget -0.103479700118878 0.000269729498350064 NA NA NA hsa-let-7c-5p MYC -0.04295851886768 0.676052842748691 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.187493318710893 0.00114816000552179 22128178 MicroRNA let 7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells prostate cancer hsa-let-7f-5p MYC 0.0508269185845673 0.62677515045793 0.0342990533418108 0.742963156666191 miRNAWalker2_validate -0.234906036376788 1.38501616912732e-05 NA NA NA hsa-let-7g-5p MYC -0.0253396334608382 0.742556489443668 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.402035322238661 2.54889860814805e-08 NA NA NA hsa-miR-145-5p MYC 0.108948399943015 0.310032352776693 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.26620175812587 1.77011092539307e-10 23919393;21836381;23499891;24356567;21092188;21690566;21723890;27482839 MicroRNA 145 function as a cell growth repressor by directly targeting c Myc in human ovarian cancer; We show that miR-145 directly target the c-Myc 3'-UTR; Moreover ectopic expression of c-Myc reduces the inhibition of cell proliferation caused by miR-145 transfection; Cell cycle assay showed that up-regulation of miR-145 reduces S phase population and restoration of c-Myc can rescue this reduction; These findings indicate that miR-145 inhibits cell proliferation and promotes cell apoptosis by targeting c-Myc 3'-UTR;The ectopic expression of miR-145 showed a significant growth inhibition in both canine and human melanoma cells tested and the effect was achieved partly by suppressing c-MYC in canine melanoma LMeC and in human melanoma A2058 and Mewo cells;The ectopic expression of miR-145 inhibited the growth of DLD-1 cells by disturbing β-catenin translocation into the nucleus thereby leading to the down-regulation of LEF/TCF transcriptional target genes c-Myc and CyclinD1;miR 145 inhibits proliferation and invasion of esophageal squamous cell carcinoma in part by targeting c Myc; The impact of overexpression of miR-145 on putative target c-Myc was subsequently confirmed via Western blot; Overexpression of miR-145 significantly decreased p < 0.05 the protein level of c-Myc which has previously been identified as a direct target of miR-145; Our results demonstrate that overexpression of miR-145 inhibits tumor growth in part by targeting c-Myc;In colon cancer cells c-Myc is a confirmed direct target for miR-145; The aim of this work was to investigate the effect of miR-145 and c-Myc on proliferation of NSCLC cells using the NSCLC cell lines A549 and H23 as models; We further showed that c-Myc was a direct target for miR-145; Taken together our study results demonstrate that miR-145 inhibits proliferation of NSCLC cells through c-Myc;miR-145 delivery reduced tumor proliferation and increased apoptosis with concomitant repression of c-Myc and ERK5 as novel regulatory target of miR-145;We found a reverse-correlation between the expression of miR-145 and its target genes such as fascin-1 c-myc SMAD2/3 and IGF-1R in breast cancer cell lines and breast cancer patient tissues;Consequently the increased miR-145 induced G1 cell cycle arrest reduced tumor proliferation and increased apoptosis inhibited HCT-116 cell migration and suppressed c-MYC expressions a regulatory target of miR-145 ;;;;;;;cell migration ovarian cancer;melanoma;colon cancer;esophageal cancer;lung squamous cell cancer;colon cancer;breast cancer;colon cancer hsa-miR-24-3p MYC 0.133257261462871 0.212960921400853 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.297311537056991 1.14667789168757e-11 NA NA NA hsa-miR-26a-5p MYC 0.033823776747294 0.726610414342369 0.0342990533418108 0.742963156666191 miRNAWalker2_validate -0.349840372726607 4.11115213986892e-11 21901171 Our results identify new molecular targets of c-Myc in AML and highlight miR-26a attractiveness as a therapeutic target in leukemia acute myeloid leukemia hsa-miR-335-5p MYC 0.0938511632756978 0.336889056387694 0.0342990533418108 0.742963156666191 miRNAWalker2_validate -0.221233805698315 6.63171764745164e-07 NA NA NA hsa-miR-34a-5p MYC 0.143472919835524 0.211283228567057 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.469833736893329 6.08752675410229e-40 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-34c-5p MYC 0.181931113688093 0.257266965617363 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase;miRanda -0.212118906251778 1.73484497587865e-16 NA NA NA hsa-miR-377-5p MYC -0.254102489855821 0.081507589808783 0.0342990533418108 0.742963156666191 miRNATAP -0.197215758202484 1.41992056070433e-11 NA NA NA hsa-miR-378a-3p MYC 0.251965146196782 0.0137483824840962 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.135286330402019 0.00204077080845563 NA NA NA hsa-miR-590-3p MYC 0.312951515438396 0.000480455423843996 0.0342990533418108 0.742963156666191 miRanda -0.223628987104378 2.58191493375387e-06 24200043 We identified important regulators MYC NFKB1 miR-590 and miR-570 and significant miRNA-TF synergistic regulatory motifs by random simulations lung squamous cell cancer hsa-miR-744-5p MYC -0.31868579180387 0.000969037378618306 0.0342990533418108 0.742963156666191 miRNAWalker2_validate -0.208939879123018 7.28554627025748e-06 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-miR-98-5p MYC -0.0806971683871618 0.251777941211683 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.482234879670646 1.25183084383233e-12 NA NA NA hsa-miR-592 OSM 0.0170005651576508 0.876633091134809 0.470952885273382 0.00656704512504158 PITA;miRNATAP -0.432777730104561 2.96495305804742e-10 NA NA NA hsa-miR-139-5p OSMR -0.647754756897633 2.15378307237163e-06 0.702146516650034 1.4597089315706e-08 miRanda -0.211914432735387 1.96756060590983e-07 NA NA NA hsa-miR-892a OSMR -0.242011750672218 0.136146245118012 0.702146516650034 1.4597089315706e-08 miRNATAP -0.116563572731247 0.000730243735238085 NA NA NA hsa-miR-362-5p PIAS2 -0.0730185557229279 0.425572997292224 0.00277486785376402 0.951133379641849 TargetScan -0.123314162204858 1.65703014855154e-10 NA NA NA hsa-miR-9-3p PIAS2 -0.184945845984695 0.0290051908009009 0.00277486785376402 0.951133379641849 mirMAP -0.12580993595741 7.92056156431908e-06 NA NA NA hsa-miR-9-5p PIAS3 -0.125377971246422 0.269896477802284 0.0749320380360103 0.0474149757814406 miRNATAP -0.143309830130979 8.25545126897712e-10 NA NA NA hsa-miR-146b-5p PIK3CA 0.441078059667297 0.000237619929889385 0.037489443318349 0.579330715365297 mirMAP -0.131612247931155 2.37773318343185e-08 NA NA NA hsa-miR-339-5p PIK3CA 0.273253751377152 0.0185300170790638 0.037489443318349 0.579330715365297 miRanda -0.104034425659594 8.90794530378182e-06 NA NA NA hsa-miR-361-5p PIK3CA 0.0107519600643302 0.882230614095565 0.037489443318349 0.579330715365297 mirMAP -0.180837597518142 0.000106487510577531 NA NA NA hsa-miR-501-5p PIK3CA 0.0878951859817452 0.309663377222443 0.037489443318349 0.579330715365297 mirMAP -0.121849868853655 0.000118457183740553 NA NA NA hsa-miR-130b-3p PIK3CB 0.503911467685709 9.46590588950823e-08 -0.219948641615068 6.65962821954743e-06 miRNATAP -0.103286697323809 1.47078743054601e-08 NA NA NA hsa-miR-19a-3p PIK3CB 0.0466707843731911 0.576818938277755 -0.219948641615068 6.65962821954743e-06 miRNATAP -0.106776286308973 5.5364329421429e-07 NA NA NA hsa-miR-19b-3p PIK3CB -0.0138427450847924 0.856506310673067 -0.219948641615068 6.65962821954743e-06 miRNATAP -0.144620281397534 1.13083007810642e-08 NA NA NA hsa-miR-25-3p PIK3CB 0.316649850160985 0.000777982468387578 -0.219948641615068 6.65962821954743e-06 miRNATAP -0.107740273525281 5.28619562870356e-06 NA NA NA hsa-miR-126-3p PIK3CG 0.283844173647452 0.0045313860754322 0.426342297358177 0.000910429107358105 miRTarBase -0.253640716789511 9.06991114742445e-05 NA NA NA hsa-miR-137 PIK3CG -0.924849266740909 1.546832202049e-06 0.426342297358177 0.000910429107358105 miRanda -0.150716294097788 1.51412490486832e-07 NA NA NA hsa-miR-139-5p PIK3CG -0.647754756897633 2.15378307237163e-06 0.426342297358177 0.000910429107358105 miRanda -0.231442980598987 3.92120693342636e-08 NA NA NA hsa-miR-103a-3p PIK3R1 -0.147443193527362 0.128400914654149 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.281302889120328 4.63842851180526e-09 NA NA NA hsa-miR-106a-5p PIK3R1 0.110074064773897 0.13045815990621 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.141577511066847 0.000568718663709082 NA NA NA hsa-miR-106b-5p PIK3R1 0.167096183547615 0.0497544396383451 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.114620357579885 0.00229922204074265 NA NA NA hsa-miR-1301-3p PIK3R1 -0.105695714210758 0.152249184194132 -0.259275224308753 0.00106935451973482 MirTarget -0.230097168026832 5.13675721710063e-09 NA NA NA hsa-miR-150-5p PIK3R1 0.0645271721519611 0.513295658828718 -0.259275224308753 0.00106935451973482 MirTarget -0.105207403299517 0.000393418533820088 NA NA NA hsa-miR-15a-5p PIK3R1 0.142658985373611 0.0536219185009004 -0.259275224308753 0.00106935451973482 MirTarget -0.230258286136212 5.21596791619245e-07 NA NA NA hsa-miR-15b-5p PIK3R1 0.592863156692837 1.41971517354055e-10 -0.259275224308753 0.00106935451973482 MirTarget -0.235643490684548 5.7801231863435e-14 NA NA NA hsa-miR-16-2-3p PIK3R1 0.468816222075619 7.04377763166292e-05 -0.259275224308753 0.00106935451973482 MirTarget -0.139286207343494 2.58317956279833e-09 NA NA NA hsa-miR-16-5p PIK3R1 0.246024668671282 0.00346042804503716 -0.259275224308753 0.00106935451973482 MirTarget -0.121551450392141 0.00217223263389569 NA NA NA hsa-miR-185-5p PIK3R1 -0.0767432095218297 0.404113540276816 -0.259275224308753 0.00106935451973482 miRNATAP -0.168972197052794 1.52142067802957e-07 NA NA NA hsa-miR-186-5p PIK3R1 0.0606381894130505 0.514217717592464 -0.259275224308753 0.00106935451973482 mirMAP -0.273384834286173 4.58184035796298e-17 NA NA NA hsa-miR-199a-3p PIK3R1 0.41226331871076 0.000497136154474528 -0.259275224308753 0.00106935451973482 miRNATAP -0.150441413618647 2.58272678316472e-10 NA NA NA hsa-miR-199a-5p PIK3R1 0.174889610847968 0.0900027418912454 -0.259275224308753 0.00106935451973482 miRanda -0.169409376623758 6.00323276983558e-10 NA NA NA hsa-miR-199b-3p PIK3R1 0.411848361704393 0.000517815011892379 -0.259275224308753 0.00106935451973482 miRNATAP -0.149610269102807 2.9670988718931e-10 NA NA NA hsa-miR-199b-5p PIK3R1 0.436298593972862 0.00200225454383871 -0.259275224308753 0.00106935451973482 miRanda -0.158988773915679 1.96615064731078e-16 NA NA NA hsa-miR-200b-3p PIK3R1 0.245768526504511 0.0580744465744737 -0.259275224308753 0.00106935451973482 mirMAP -0.203398688722103 1.6080278648636e-21 NA NA NA hsa-miR-200c-3p PIK3R1 0.413752622631695 8.6936333715621e-06 -0.259275224308753 0.00106935451973482 mirMAP -0.313372851003899 1.11853298374691e-27 NA NA NA hsa-miR-21-5p PIK3R1 1.0504925175311 2.58081295984106e-11 -0.259275224308753 0.00106935451973482 miRNAWalker2_validate;MirTarget;miRNATAP -0.192193122796698 2.35557430088274e-23 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 0.0437233965539527 0.639996108995995 -0.259275224308753 0.00106935451973482 mirMAP -0.26421716056902 5.35024336821731e-19 NA NA NA hsa-miR-221-3p PIK3R1 -0.0109507285071775 0.936440693394519 -0.259275224308753 0.00106935451973482 MirTarget -0.125242954911868 1.02528886125279e-09 NA NA NA hsa-miR-222-3p PIK3R1 0.107117065575197 0.423818119725697 -0.259275224308753 0.00106935451973482 MirTarget -0.132930686168698 1.29543187744781e-10 NA NA NA hsa-miR-28-5p PIK3R1 0.104003572105781 0.153594705579534 -0.259275224308753 0.00106935451973482 miRanda -0.263804174247158 1.47407900801522e-10 NA NA NA hsa-miR-29b-3p PIK3R1 -0.178522712044497 0.0856106432165465 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.145678229090259 1.47483484512088e-06 NA NA NA hsa-miR-320a PIK3R1 0.092135599636725 0.243028758989929 -0.259275224308753 0.00106935451973482 miRNATAP -0.135112165926423 0.00256497204146449 NA NA NA hsa-miR-320c PIK3R1 0.343259124189966 0.000248338401291051 -0.259275224308753 0.00106935451973482 miRNATAP -0.100797336995439 0.0011155444118643 NA NA NA hsa-miR-361-5p PIK3R1 0.0107519600643302 0.882230614095565 -0.259275224308753 0.00106935451973482 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.28102979614435 4.07903189307061e-09 NA NA NA hsa-miR-374a-3p PIK3R1 0.176226170437625 0.0343958848425446 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.321250741910251 7.52372972851822e-15 NA NA NA hsa-miR-424-5p PIK3R1 0.25140374049676 0.00709934939774983 -0.259275224308753 0.00106935451973482 MirTarget -0.179589895147171 9.52256678975884e-09 NA NA NA hsa-miR-455-3p PIK3R1 0.512701816402104 0.000459755983280155 -0.259275224308753 0.00106935451973482 MirTarget;PITA;miRNATAP -0.161697245880861 9.23450362337655e-18 NA NA NA hsa-miR-532-3p PIK3R1 0.150624483952741 0.0599635132177191 -0.259275224308753 0.00106935451973482 MirTarget -0.152797062588971 2.75979429090484e-05 NA NA NA hsa-miR-542-3p PIK3R1 0.0835995677900829 0.403838744494071 -0.259275224308753 0.00106935451973482 MirTarget;PITA;miRanda -0.126538995109648 4.83333922747737e-05 NA NA NA hsa-miR-548b-3p PIK3R1 0.340474544210108 0.00224491592019745 -0.259275224308753 0.00106935451973482 mirMAP -0.215757322792441 3.83990685247808e-18 NA NA NA hsa-miR-589-3p PIK3R1 0.00739371736361305 0.927768051649329 -0.259275224308753 0.00106935451973482 mirMAP -0.128475712773886 0.000234342022369328 NA NA NA hsa-miR-590-3p PIK3R1 0.312951515438396 0.000480455423843996 -0.259275224308753 0.00106935451973482 miRanda;mirMAP -0.281948259643294 1.55243456524174e-20 NA NA NA hsa-miR-590-5p PIK3R1 0.16946027035949 0.0386004382081678 -0.259275224308753 0.00106935451973482 MirTarget;PITA;miRanda;miRNATAP -0.237039982006307 4.44595475697952e-12 NA NA NA hsa-miR-93-5p PIK3R1 0.139766237971122 0.101057320076629 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.261542441732551 2.52352152477154e-07 NA NA NA hsa-miR-125a-3p PIK3R2 0.183834985432376 0.106230647107917 0.0588428389717066 0.330993461191286 miRanda -0.129596879826368 7.29774749644301e-14 NA NA NA hsa-miR-135a-5p PIK3R2 -0.122734612943241 0.196985964641886 0.0588428389717066 0.330993461191286 MirTarget;miRNATAP -0.131986778854444 6.81341317924018e-10 NA NA NA hsa-miR-28-5p PIK3R2 0.104003572105781 0.153594705579534 0.0588428389717066 0.330993461191286 miRanda -0.220439409614541 1.97006000122873e-14 NA NA NA hsa-miR-30a-5p PIK3R2 -0.062942936611238 0.513851954700252 0.0588428389717066 0.330993461191286 miRNATAP -0.422270293356803 9.55851299393926e-41 NA NA NA hsa-miR-30b-5p PIK3R2 -0.0858101016322106 0.263243418521854 0.0588428389717066 0.330993461191286 miRNATAP -0.124149959343624 7.09161751121272e-05 NA NA NA hsa-miR-30c-5p PIK3R2 -0.0469114469943097 0.565934557464627 0.0588428389717066 0.330993461191286 miRNAWalker2_validate;miRNATAP -0.240340425585456 4.99963373312426e-15 NA NA NA hsa-miR-30d-5p PIK3R2 -0.0607010868720046 0.471410043548794 0.0588428389717066 0.330993461191286 miRNATAP -0.157898559984916 9.76384983421278e-06 NA NA NA hsa-miR-30e-5p PIK3R2 0.0764521828640934 0.41904991629622 0.0588428389717066 0.330993461191286 miRNATAP -0.28288573453624 2.98060149038092e-23 NA NA NA hsa-miR-331-3p PIK3R2 0.0126984726684189 0.905175053956974 0.0588428389717066 0.330993461191286 MirTarget -0.109375813751675 5.11486213404741e-09 NA NA NA hsa-miR-339-5p PIK3R2 0.273253751377152 0.0185300170790638 0.0588428389717066 0.330993461191286 miRanda -0.141580109769359 1.93632849649246e-17 NA NA NA hsa-miR-34a-5p PIK3R2 0.143472919835524 0.211283228567057 0.0588428389717066 0.330993461191286 MirTarget -0.127777793508925 2.24958566486742e-13 NA NA NA hsa-miR-9-3p PIK3R3 -0.184945845984695 0.0290051908009009 0.266207970572364 5.77735138484935e-05 mirMAP -0.147414732691119 0.000303043365501486 NA NA NA hsa-miR-9-5p PIK3R3 -0.125377971246422 0.269896477802284 0.266207970572364 5.77735138484935e-05 miRNATAP -0.234645741849474 2.452186835562e-05 NA NA NA hsa-miR-767-3p PIM1 -0.429854368420513 0.000821445291167688 0.508258356168361 2.69678858677866e-12 PITA;miRNATAP -0.101260720372964 4.34511940333268e-05 NA NA NA hsa-miR-454-3p PRLR 0.177318549827649 0.0120865170334418 -0.090634989600836 0.414123305437059 mirMAP -0.188829502619545 0.00819269251358993 NA NA NA hsa-miR-9-3p PRLR -0.184945845984695 0.0290051908009009 -0.090634989600836 0.414123305437059 mirMAP -0.886168896864937 3.20981795524244e-34 NA NA NA hsa-miR-9-5p PRLR -0.125377971246422 0.269896477802284 -0.090634989600836 0.414123305437059 miRNATAP -1.18446280913297 1.25226082012491e-32 NA NA NA hsa-miR-19a-3p PTPN11 0.0466707843731911 0.576818938277755 -0.128832291150953 0.0425631030517416 mirMAP -0.107814047213024 3.87455311201701e-06 NA NA NA hsa-miR-19b-3p PTPN11 -0.0138427450847924 0.856506310673067 -0.128832291150953 0.0425631030517416 mirMAP -0.14042623414932 4.26553855796372e-07 NA NA NA hsa-miR-320a PTPN11 0.092135599636725 0.243028758989929 -0.128832291150953 0.0425631030517416 miRNAWalker2_validate;mirMAP -0.10812909554291 0.000266325538481357 NA NA NA hsa-miR-129-5p SOCS2 -0.567133990117126 0.00116152215679936 0.580576729364487 3.02551308202861e-07 miRanda -0.130394819125054 5.64073849270883e-06 NA NA NA hsa-miR-139-5p SOCS2 -0.647754756897633 2.15378307237163e-06 0.580576729364487 3.02551308202861e-07 PITA;miRanda;miRNATAP -0.271928867347072 8.08412662717116e-14 NA NA NA hsa-miR-767-5p SOCS2 -0.551653504513145 2.61109058244854e-05 0.580576729364487 3.02551308202861e-07 miRNATAP -0.385985477061046 2.79030197570232e-26 NA NA NA hsa-let-7d-5p SOCS4 0.111345229817909 0.0872634398336815 0.0826748187944233 0.0783026605837547 miRNATAP -0.135332521930463 1.43887846717822e-05 NA NA NA hsa-miR-140-3p SOCS4 -0.123864258867705 0.14796686619449 0.0826748187944233 0.0783026605837547 PITA;miRNATAP -0.126042482315736 5.91060885385843e-07 NA NA NA hsa-miR-664a-3p SOCS4 0.0413918462467198 0.611334357897022 0.0826748187944233 0.0783026605837547 mirMAP -0.113728299001778 3.05564520792884e-08 NA NA NA hsa-miR-9-5p SOCS5 -0.125377971246422 0.269896477802284 -0.0367795465916823 0.38385096576769 miRNAWalker2_validate;miRTarBase -0.102514312547928 0.00158866174702415 27447934 Analysis showed that miR-9 targets e-cadherin and suppressor of cytokine signalling 5 SOCS5 but not NF-ĸB mRNA prostate cancer hsa-miR-141-3p SOCS7 0.41120561991992 0.000393344390969055 -0.167714365681777 0.130901880913054 TargetScan -0.158888339077446 0.000156352350317631 NA NA NA hsa-miR-320a SOCS7 0.092135599636725 0.243028758989929 -0.167714365681777 0.130901880913054 PITA;miRanda -0.267983206928506 0.000435739065431421 NA NA NA hsa-miR-22-5p SOS1 0.0437233965539527 0.639996108995995 0.00523748905885846 0.912745973623718 miRNATAP -0.124027312186166 1.41352250447066e-15 NA NA NA hsa-miR-30a-5p SOS1 -0.062942936611238 0.513851954700252 0.00523748905885846 0.912745973623718 mirMAP;miRNATAP -0.177492800844273 6.3171352970898e-13 NA NA NA hsa-miR-30b-5p SOS1 -0.0858101016322106 0.263243418521854 0.00523748905885846 0.912745973623718 mirMAP -0.16385231555963 4.41286025144966e-13 NA NA NA hsa-miR-30c-2-3p SOS1 -0.18630560418806 0.0313113706136533 0.00523748905885846 0.912745973623718 MirTarget -0.104452765489338 1.12374921832207e-08 NA NA NA hsa-miR-30c-5p SOS1 -0.0469114469943097 0.565934557464627 0.00523748905885846 0.912745973623718 mirMAP;miRNATAP -0.197561323004552 1.3758821302056e-18 NA NA NA hsa-miR-361-5p SOS1 0.0107519600643302 0.882230614095565 0.00523748905885846 0.912745973623718 miRanda -0.115873078362459 3.5425762216149e-06 NA NA NA hsa-miR-365a-3p SOS1 -0.184222766207919 0.0292663235724171 0.00523748905885846 0.912745973623718 miRNATAP -0.149763665687287 4.3259532044635e-18 NA NA NA hsa-miR-664a-3p SOS1 0.0413918462467198 0.611334357897022 0.00523748905885846 0.912745973623718 mirMAP -0.132986198696247 2.29333790618546e-13 NA NA NA hsa-miR-146b-5p SOS2 0.441078059667297 0.000237619929889385 -0.136173831265531 0.0089381592916821 miRanda -0.155137029146937 3.46260583915288e-27 NA NA NA hsa-miR-15a-5p SOS2 0.142658985373611 0.0536219185009004 -0.136173831265531 0.0089381592916821 miRNATAP -0.11015727851104 9.81799896258958e-05 NA NA NA hsa-miR-15b-5p SOS2 0.592863156692837 1.41971517354055e-10 -0.136173831265531 0.0089381592916821 miRNATAP -0.149377221011986 7.33700935351651e-15 NA NA NA hsa-miR-664a-3p SOS2 0.0413918462467198 0.611334357897022 -0.136173831265531 0.0089381592916821 mirMAP -0.18595244526209 1.63522338473879e-18 NA NA NA hsa-let-7a-3p SPRED1 0.0530563276543763 0.370749834463566 0.242877275737778 0.0014326070884495 miRNATAP -0.28909400710323 6.97266723552589e-07 NA NA NA hsa-miR-135a-5p SPRED1 -0.122734612943241 0.196985964641886 0.242877275737778 0.0014326070884495 miRNATAP -0.246582584957452 8.61512216034978e-14 NA NA NA hsa-miR-26b-5p SPRED1 -0.0984536538762768 0.231803769574623 0.242877275737778 0.0014326070884495 miRNATAP -0.163149219600643 0.000296719174454706 NA NA NA hsa-miR-301a-3p SPRED1 0.00956875714542704 0.916380325220259 0.242877275737778 0.0014326070884495 miRNATAP -0.285918913708709 1.6242191973459e-16 NA NA NA hsa-miR-3065-5p SPRED1 -0.262608140481507 0.0414570974148034 0.242877275737778 0.0014326070884495 mirMAP -0.293799802071892 2.86469673089521e-39 NA NA NA hsa-miR-374a-5p SPRED1 0.0121037060909277 0.865417963345881 0.242877275737778 0.0014326070884495 mirMAP -0.155838834789941 0.000888187066686803 NA NA NA hsa-miR-374b-5p SPRED1 -0.210113949579608 0.0056866083818614 0.242877275737778 0.0014326070884495 mirMAP -0.288175042655509 2.83213896166367e-10 NA NA NA hsa-miR-454-3p SPRED1 0.177318549827649 0.0120865170334418 0.242877275737778 0.0014326070884495 miRNATAP -0.16210636260921 0.000401867462720162 NA NA NA hsa-miR-497-5p SPRED1 -0.000783764887886562 0.991703566618871 0.242877275737778 0.0014326070884495 miRNATAP -0.139934937958786 0.00157607384112961 NA NA NA hsa-miR-589-3p SPRED1 0.00739371736361305 0.927768051649329 0.242877275737778 0.0014326070884495 mirMAP -0.164212061751844 1.80499496455911e-05 NA NA NA hsa-miR-708-3p SPRED1 0.00458267260363954 0.962455132950708 0.242877275737778 0.0014326070884495 miRNATAP -0.250881982849732 6.80309323574381e-13 NA NA NA hsa-miR-92b-3p SPRED1 -0.213968504161963 0.0523921855715716 0.242877275737778 0.0014326070884495 mirMAP -0.227760461614394 1.37004167075637e-12 NA NA NA hsa-miR-93-3p SPRED1 0.0778767956494004 0.272224943247293 0.242877275737778 0.0014326070884495 miRNATAP -0.216442322974575 2.00007038577234e-06 NA NA NA hsa-miR-106b-5p SPRED2 0.167096183547615 0.0497544396383451 0.408387652411419 2.51733983643745e-06 mirMAP -0.138239789359352 0.0050051130253118 NA NA NA hsa-miR-17-5p SPRED2 0.0975751369167082 0.20621110214601 0.408387652411419 2.51733983643745e-06 mirMAP -0.172628872752948 0.00372189516341926 NA NA NA hsa-miR-186-5p SPRED2 0.0606381894130505 0.514217717592464 0.408387652411419 2.51733983643745e-06 miRNAWalker2_validate -0.253357898546229 5.10632656017442e-09 NA NA NA hsa-miR-20a-5p SPRED2 -0.0115865752288853 0.887069448776018 0.408387652411419 2.51733983643745e-06 mirMAP -0.144651610963834 0.00802637553914405 NA NA NA hsa-miR-362-5p SPRED2 -0.0730185557229279 0.425572997292224 0.408387652411419 2.51733983643745e-06 PITA -0.133347454952552 0.00116661442655443 NA NA NA hsa-miR-421 SPRED2 -0.171573235029879 0.0518112933651029 0.408387652411419 2.51733983643745e-06 miRanda -0.1803171155592 1.6767263780247e-05 NA NA NA hsa-miR-93-5p SPRED2 0.139766237971122 0.101057320076629 0.408387652411419 2.51733983643745e-06 mirMAP -0.175704967547918 0.00876162531074964 NA NA NA hsa-miR-129-5p SPRY1 -0.567133990117126 0.00116152215679936 0.744859554143757 7.13743723655852e-13 miRanda -0.106587967372138 6.86058035626931e-05 NA NA NA hsa-miR-20a-3p SPRY1 0.102743778777997 0.19677865359751 0.744859554143757 7.13743723655852e-13 miRNATAP -0.165163116802867 0.00480349524434112 NA NA NA hsa-miR-338-5p SPRY1 -0.424003687569629 0.00246415720301323 0.744859554143757 7.13743723655852e-13 miRNATAP -0.12092997444351 0.000254865841611131 NA NA NA hsa-let-7a-3p SPRY2 0.0530563276543763 0.370749834463566 0.2710309525654 0.000797422133520833 miRNATAP -0.206123747330449 0.000925516708673978 NA NA NA hsa-miR-181a-5p SPRY2 -0.178215604431845 0.0700010802255601 0.2710309525654 0.000797422133520833 miRNAWalker2_validate -0.140031759738171 0.00228803684934165 NA NA NA hsa-miR-125a-3p SPRY3 0.183834985432376 0.106230647107917 0.0200098064820047 0.764132137579644 miRanda;miRNATAP -0.102509255781844 5.43691742254117e-05 NA NA NA hsa-miR-141-3p SPRY3 0.41120561991992 0.000393344390969055 0.0200098064820047 0.764132137579644 mirMAP -0.128693693891298 2.38189325495778e-07 NA NA NA hsa-miR-186-5p SPRY3 0.0606381894130505 0.514217717592464 0.0200098064820047 0.764132137579644 mirMAP -0.31443268667111 7.34096388542284e-22 NA NA NA hsa-miR-200b-3p SPRY3 0.245768526504511 0.0580744465744737 0.0200098064820047 0.764132137579644 mirMAP -0.107602043797098 1.51586176984068e-06 NA NA NA hsa-miR-200c-3p SPRY3 0.413752622631695 8.6936333715621e-06 0.0200098064820047 0.764132137579644 mirMAP -0.188677884488723 4.70811846901051e-10 NA NA NA hsa-miR-223-3p SPRY3 -0.0272428307560952 0.814395950305568 0.0200098064820047 0.764132137579644 mirMAP -0.17301580526394 5.18626009460957e-12 NA NA NA hsa-miR-26b-3p SPRY3 -0.0542537787460029 0.4802214385739 0.0200098064820047 0.764132137579644 mirMAP -0.17467960667799 5.68308211324983e-06 NA NA NA hsa-miR-28-3p SPRY3 0.139444423971018 0.0811187936164314 0.0200098064820047 0.764132137579644 miRNATAP -0.288800543284124 2.97927375627013e-10 NA NA NA hsa-miR-28-5p SPRY3 0.104003572105781 0.153594705579534 0.0200098064820047 0.764132137579644 MirTarget;miRNATAP -0.144154752277055 0.000671734988078067 NA NA NA hsa-miR-296-5p SPRY3 -0.0192165981442809 0.870822664524408 0.0200098064820047 0.764132137579644 miRNATAP -0.122811229913505 3.59563630309171e-07 NA NA NA hsa-miR-29a-5p SPRY3 -0.0697727833812678 0.350621682973119 0.0200098064820047 0.764132137579644 mirMAP -0.132978646039991 0.000682318049191199 NA NA NA hsa-miR-30a-3p SPRY3 0.0655410309550977 0.509541256241954 0.0200098064820047 0.764132137579644 mirMAP -0.165505649783413 9.90738520713648e-06 NA NA NA hsa-miR-30e-3p SPRY3 0.00173769765874887 0.984965501547409 0.0200098064820047 0.764132137579644 mirMAP -0.336944585774877 4.16459716041099e-16 NA NA NA hsa-miR-320a SPRY3 0.092135599636725 0.243028758989929 0.0200098064820047 0.764132137579644 miRNAWalker2_validate;miRanda;mirMAP -0.137612134804834 0.00248619462261208 NA NA NA hsa-miR-339-5p SPRY3 0.273253751377152 0.0185300170790638 0.0200098064820047 0.764132137579644 miRanda -0.146626681748965 1.82995684332262e-09 NA NA NA hsa-miR-362-5p SPRY3 -0.0730185557229279 0.425572997292224 0.0200098064820047 0.764132137579644 TargetScan;miRNATAP -0.149388797909503 2.40406610418883e-06 NA NA NA hsa-miR-3622a-3p SPRY3 0.0389203848593471 0.75605812962459 0.0200098064820047 0.764132137579644 MirTarget;miRNATAP -0.153221876865145 2.52368085402531e-11 NA NA NA hsa-miR-374a-3p SPRY3 0.176226170437625 0.0343958848425446 0.0200098064820047 0.764132137579644 mirMAP -0.259559258409178 9.31598002216628e-10 NA NA NA hsa-miR-421 SPRY3 -0.171573235029879 0.0518112933651029 0.0200098064820047 0.764132137579644 mirMAP -0.175189328283443 5.98098802343549e-08 NA NA NA hsa-miR-452-5p SPRY3 0.599327068454211 1.02031931068531e-05 0.0200098064820047 0.764132137579644 MirTarget;mirMAP -0.102273056535899 8.23109042118618e-07 NA NA NA hsa-miR-455-3p SPRY3 0.512701816402104 0.000459755983280155 0.0200098064820047 0.764132137579644 miRNATAP -0.103627242891557 1.1404336932333e-07 NA NA NA hsa-miR-501-5p SPRY3 0.0878951859817452 0.309663377222443 0.0200098064820047 0.764132137579644 mirMAP;miRNATAP -0.112986298251136 0.000684356305452939 NA NA NA hsa-miR-576-5p SPRY3 0.106482276040047 0.194379152564166 0.0200098064820047 0.764132137579644 mirMAP -0.301749910617512 1.47710465240326e-18 NA NA NA hsa-miR-589-3p SPRY3 0.00739371736361305 0.927768051649329 0.0200098064820047 0.764132137579644 mirMAP -0.190360833625707 6.35207337473736e-08 NA NA NA hsa-miR-590-3p SPRY3 0.312951515438396 0.000480455423843996 0.0200098064820047 0.764132137579644 mirMAP -0.184416516716271 5.23344085361864e-09 NA NA NA hsa-miR-629-5p SPRY3 0.100422082714475 0.214291160007531 0.0200098064820047 0.764132137579644 MirTarget;mirMAP -0.278700859320144 1.5934781616026e-13 NA NA NA hsa-miR-708-3p SPRY3 0.00458267260363954 0.962455132950708 0.0200098064820047 0.764132137579644 MirTarget;mirMAP -0.272267033702451 1.55935097040119e-17 NA NA NA hsa-miR-708-5p SPRY3 -0.00936519718301376 0.919857671524527 0.0200098064820047 0.764132137579644 MirTarget -0.272782298504165 7.2013916437926e-17 NA NA NA hsa-miR-181a-2-3p SPRY4 -0.0630409614874416 0.473088318215936 0.785548755689999 4.23106792742195e-07 mirMAP -0.491105930224715 6.5984571538006e-06 NA NA NA hsa-miR-181c-5p SPRY4 -0.285631740307867 0.00281600994521758 0.785548755689999 4.23106792742195e-07 miRNATAP -0.276261553447281 0.000504960761827841 NA NA NA hsa-miR-488-5p SPRY4 -0.385755602369049 7.99431673275965e-08 0.785548755689999 4.23106792742195e-07 mirMAP -0.387324107557544 8.47960367901929e-05 NA NA NA hsa-miR-497-5p SPRY4 -0.000783764887886562 0.991703566618871 0.785548755689999 4.23106792742195e-07 miRNATAP -0.276096700089748 0.00461136690050326 NA NA NA hsa-miR-25-3p STAM 0.316649850160985 0.000777982468387578 -0.190331636217357 0.000201374464962495 MirTarget -0.120786386501957 3.04305090805588e-06 NA NA NA hsa-miR-335-3p STAM 0.34540584335595 0.00043848660222294 -0.190331636217357 0.000201374464962495 MirTarget -0.129606701620744 2.57850026151757e-11 NA NA NA hsa-miR-361-5p STAM2 0.0107519600643302 0.882230614095565 -0.0239799806515313 0.542308160871261 miRanda -0.121298865851125 9.15027486673301e-10 NA NA NA hsa-miR-320a STAT4 0.092135599636725 0.243028758989929 -0.236746283606031 0.234213380227805 MirTarget;PITA;miRanda -0.724028036036533 1.26811673374686e-07 NA NA NA hsa-miR-320b STAT4 0.283477746304177 0.0005953763020907 -0.236746283606031 0.234213380227805 MirTarget;PITA;miRanda -0.289911899732703 0.00593349626205564 NA NA NA hsa-miR-320c STAT4 0.343259124189966 0.000248338401291051 -0.236746283606031 0.234213380227805 MirTarget;PITA;miRanda -0.434962452987884 4.63905362709499e-06 NA NA NA hsa-miR-935 STAT5A -0.277848050075718 0.02166231531395 0.27243880874046 0.00263321544102836 mirMAP -0.104185995086551 0.00140390570906267 NA NA NA hsa-let-7a-3p TSLP 0.0530563276543763 0.370749834463566 -0.262193538648163 0.0623508201951788 MirTarget -0.592933029034858 2.61921092261048e-07 NA NA NA