miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-21-5p AKT2 1.75445050487988 2.41825549682022e-23 -0.0135478038511252 0.922701697200587 miRNAWalker2_validate -0.147206602823392 0.00352458167442573 NA NA NA hsa-miR-29b-3p AKT2 -0.230693226193598 0.367461626035234 -0.0135478038511252 0.922701697200587 MirTarget -0.141689777106604 0.000224365237662475 26512921;26564501;24076586 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3;The expression of miR-29b was significantly upregualted by cisplatin treatmentwhile its target gene AKT2 was downregulated;Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis ;; ovarian cancer;gastric cancer;acute myeloid leukemia hsa-miR-106b-5p AKT3 1.70863907461894 2.04074794107142e-08 -0.748577301508132 0.0693608036068007 miRNATAP -0.368902671357459 6.63579377990938e-05 NA NA NA hsa-miR-107 AKT3 0.904627575346218 4.67936495073904e-05 -0.748577301508132 0.0693608036068007 PITA;miRanda -0.596025797372068 4.38261497597827e-06 NA NA NA hsa-miR-15b-5p AKT3 1.62046407540723 5.42152621571078e-09 -0.748577301508132 0.0693608036068007 miRNATAP -0.359857777182961 0.000407223981183838 NA NA NA hsa-miR-16-5p AKT3 1.00515772948091 5.33912942007619e-06 -0.748577301508132 0.0693608036068007 miRNAWalker2_validate;miRTarBase;miRNATAP -0.473860841884761 0.000305952592817196 NA NA NA hsa-miR-17-3p AKT3 1.31126744284937 3.24768335024185e-07 -0.748577301508132 0.0693608036068007 miRNATAP -0.520864813647553 2.25932722443508e-06 NA NA NA hsa-miR-17-5p AKT3 1.65862087862483 8.45603406215941e-08 -0.748577301508132 0.0693608036068007 TargetScan;miRNATAP -0.276276453758938 0.00270096970703173 NA NA NA hsa-miR-29a-3p AKT3 -0.113012156986374 0.615005009685815 -0.748577301508132 0.0693608036068007 miRNATAP -0.408748871699734 0.00212322174807936 NA NA NA hsa-miR-29b-3p AKT3 -0.230693226193598 0.367461626035234 -0.748577301508132 0.0693608036068007 miRNATAP -0.338134432146425 0.00361456599882575 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-32-3p AKT3 0.583525764322974 0.11837203008551 -0.748577301508132 0.0693608036068007 mirMAP -0.324144417685552 0.000230218736536503 NA NA NA hsa-miR-320b AKT3 1.11183660885284 0.000497971211648503 -0.748577301508132 0.0693608036068007 PITA;miRanda;miRNATAP -0.263235906209639 0.00390234919135454 NA NA NA hsa-miR-335-3p AKT3 2.5197689063267 2.20084506976733e-09 -0.748577301508132 0.0693608036068007 mirMAP -0.224460236877792 0.000742588100170571 NA NA NA hsa-miR-33a-3p AKT3 0.347011402017138 0.321709379745392 -0.748577301508132 0.0693608036068007 mirMAP -0.376513667394311 1.68302152281553e-05 NA NA NA hsa-miR-362-3p AKT3 -0.0349414695893027 0.913780708043777 -0.748577301508132 0.0693608036068007 miRanda -0.37545416085904 3.60412362584734e-05 NA NA NA hsa-miR-362-5p AKT3 -0.354508685915981 0.354912078595613 -0.748577301508132 0.0693608036068007 PITA;TargetScan;miRNATAP -0.231850776707854 0.00252522310690117 NA NA NA hsa-miR-501-3p AKT3 0.731876211669996 0.0270421347018303 -0.748577301508132 0.0693608036068007 miRNATAP -0.389710500003727 8.30408434984544e-06 NA NA NA hsa-miR-502-3p AKT3 -0.16442685491191 0.557471818466728 -0.748577301508132 0.0693608036068007 miRNATAP -0.502835122914366 1.28261107693995e-06 NA NA NA hsa-miR-505-3p AKT3 0.82660100642669 0.00111666333288398 -0.748577301508132 0.0693608036068007 mirMAP -0.351999859841566 0.0023495079245673 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-548v AKT3 -0.156004387355895 0.708665170641638 -0.748577301508132 0.0693608036068007 miRNATAP -0.26608196493585 0.000310856014668821 NA NA NA hsa-miR-577 AKT3 0.911619788986754 0.2256062124148 -0.748577301508132 0.0693608036068007 mirMAP -0.230357457399908 2.14832389488646e-09 NA NA NA hsa-miR-616-5p AKT3 0.834052908652744 0.0347835664029363 -0.748577301508132 0.0693608036068007 mirMAP -0.265580906698402 0.000411824587413266 NA NA NA hsa-miR-429 ANGPT1 1.40182602301928 0.00900426780286475 -0.527270855014746 0.283336633574923 miRanda -0.303872006325128 1.59249703357909e-06 NA NA NA hsa-miR-129-5p ANGPT2 -2.56914016541176 2.36237896095709e-06 1.69586907431828 1.76346718161662e-07 MirTarget;miRanda -0.127754969681771 0.00317938631188512 NA NA NA hsa-miR-145-5p ANGPT2 -1.75133578902314 1.54965572197748e-05 1.69586907431828 1.76346718161662e-07 MirTarget;miRNATAP -0.219550526534805 0.00012074406146925 24384875;27570490 miR 145 functions as tumor suppressor and targets two oncogenes ANGPT2 and NEDD9 in renal cell carcinoma; We further validated those miR-145 targets two oncogenes ANGPT2 and NEDD9 in RCC;MiR 145 functions as a tumor suppressor via regulating angiopoietin 2 in pancreatic cancer cells; The direct action of miR-145 on Ang-2 was predicted by TargetScan and confirmed by luciferase report assay; The expression level of miR-145 was significantly lower and the expression levels of Ang-2 mRNA and protein was significantly higher in the more aggressive pancreatic cancer cells MiaPaCa-2 and Panc-1 when compared to that in BxPC3 cells; Overexpression of miR-145 in the BxPC3 MiaPaCa-2 and Panc-1 cells suppressed the cell invasion and colony formation ability and the expression level of Ang-2 protein in MiaPaCa-2 and Panc-1 cells was also suppressed after pre-miR-145 transfection; Intratumoral delivery of miR-145 inhibited the growth of pancreatic cancer xenografts and angiogenesis in vivo and also suppressed the expression level of angiopoietin-2 protein; MiR-145 functions as a tumor suppressor in pancreatic cancer cells by targeting Ang-2 for translation repression and thus suppresses pancreatic cancer cell invasion and growth which suggests that restoring of miR-145 may be a potential therapeutic target for pancreatic cancer ; kidney renal cell cancer;pancreatic cancer hsa-miR-664a-3p ANGPT2 -0.83041219170254 0.000136267547251167 1.69586907431828 1.76346718161662e-07 mirMAP -0.367845167537421 0.000759285521024805 NA NA NA hsa-miR-10b-5p ATF2 -0.304747636331676 0.312390370183001 -0.0211402510118752 0.898437673335987 MirTarget;miRNATAP -0.131615688052157 0.000676362787084052 NA NA NA hsa-miR-126-5p ATF2 0.41765430251855 0.0753161203651532 -0.0211402510118752 0.898437673335987 mirMAP -0.149080974896046 0.00298616280876826 NA NA NA hsa-miR-212-3p ATF2 0.960352937108106 0.00133449812322732 -0.0211402510118752 0.898437673335987 miRNATAP -0.140898430644047 0.000260454715443413 NA NA NA hsa-miR-590-3p ATF2 1.11654983899947 0.000160782154924864 -0.0211402510118752 0.898437673335987 MirTarget;miRanda;mirMAP;miRNATAP -0.11720062607551 0.00262610190811212 NA NA NA hsa-miR-342-3p ATF6B 0.318119432680668 0.269150960124243 0.490374515137253 0.00379985339771186 miRanda -0.152162768864503 0.000285413242818201 NA NA NA hsa-miR-15b-3p BCL2 1.75738933306437 3.00554466232543e-08 -1.09374208002759 0.00317080214601605 mirMAP -0.23817009094778 0.00334370547706688 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-16-2-3p BCL2 1.8048179609245 2.83095715136409e-09 -1.09374208002759 0.00317080214601605 mirMAP -0.256921078159685 0.0022954047853729 NA NA NA hsa-miR-200a-5p BCL2 1.50371809098978 0.00263602434344863 -1.09374208002759 0.00317080214601605 mirMAP -0.211128800630803 4.95343554899065e-05 NA NA NA hsa-miR-200b-3p BCL2 0.974577911407732 0.0595020056914543 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase;TargetScan;mirMAP -0.182246427033851 0.000341103736622929 NA NA NA hsa-miR-200b-5p BCL2 0.969871521250413 0.0530500454130183 -1.09374208002759 0.00317080214601605 mirMAP -0.205249290010733 0.000189759214886854 NA NA NA hsa-miR-200c-3p BCL2 1.28185685499076 0.00369777635539177 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase;mirMAP -0.226804029845278 0.000126679308092617 NA NA NA hsa-miR-20a-3p BCL2 1.13957127410163 0.000451087640268489 -1.09374208002759 0.00317080214601605 mirMAP -0.220252577355485 0.00668844206923876 NA NA NA hsa-miR-21-5p BCL2 1.75445050487988 2.41825549682022e-23 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase -0.574405109042944 2.28190201261615e-05 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-29a-5p BCL2 0.585084040404152 0.023014129158495 -1.09374208002759 0.00317080214601605 mirMAP -0.284870122627372 0.0062184185769466 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-335-3p BCL2 2.5197689063267 2.20084506976733e-09 -1.09374208002759 0.00317080214601605 mirMAP -0.166369508302009 0.00598265233221658 NA NA NA hsa-miR-429 BCL2 1.40182602301928 0.00900426780286475 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase;PITA;mirMAP -0.202333078759473 3.04924059291668e-05 23999873;26513239;26511969 MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation ;; esophageal cancer;gastric cancer;glioblastoma hsa-miR-455-5p BCL2 1.20462751989145 6.74386011867484e-05 -1.09374208002759 0.00317080214601605 mirMAP -0.354129750010572 3.78782094978964e-05 NA NA NA hsa-miR-577 BCL2 0.911619788986754 0.2256062124148 -1.09374208002759 0.00317080214601605 PITA -0.10050287983592 0.00537086108513998 NA NA NA hsa-miR-7-5p BCL2 1.63575693499363 0.0124424214624534 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase;mirMAP -0.142794989912626 0.000680645769025094 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-let-7b-5p BCL2L1 0.0582902155815681 0.781400138984745 0.213751739166448 0.395782450784369 miRNATAP -0.314285217081765 0.000268924662830079 26915294;20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA poor survival; lung cancer;liver cancer hsa-let-7c-5p BCL2L1 -0.503482361446512 0.206848395212976 0.213751739166448 0.395782450784369 miRNAWalker2_validate;miRTarBase -0.198493465039984 6.59628301755695e-06 20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA liver cancer hsa-miR-149-5p BCL2L1 0.706277554734069 0.296848731347677 0.213751739166448 0.395782450784369 mirMAP -0.173000301400021 4.12180118165392e-12 NA NA NA hsa-miR-214-3p BCL2L1 1.01201534142544 0.00625092909225755 0.213751739166448 0.395782450784369 mirMAP -0.12678075713813 0.00823737366000966 NA NA NA hsa-miR-23b-3p BCL2L1 -0.286465516491361 0.18664668472995 0.213751739166448 0.395782450784369 miRNAWalker2_validate -0.389042865664013 2.23464331013867e-06 NA NA NA hsa-miR-192-3p BDNF 0.355565421687399 0.74117031340037 0.736006518564608 0.183812338919891 MirTarget;miRNATAP -0.106082522009255 0.00423859909260241 NA NA NA hsa-miR-29b-2-5p BDNF -1.7015307882027 2.84239251703401e-10 0.736006518564608 0.183812338919891 mirMAP -0.375479531938686 0.00761861774409137 NA NA NA hsa-miR-338-5p BDNF -1.19659203838734 0.0100316010080496 0.736006518564608 0.183812338919891 miRNATAP -0.30035007324931 0.000332002329074772 NA NA NA hsa-miR-193b-3p CASP9 0.281752012268679 0.451258902263119 -0.314756842171161 0.110040278687801 miRNAWalker2_validate -0.173981251979618 2.15802379337291e-06 NA NA NA hsa-miR-338-3p CCND1 -0.959276231066179 0.0191473351014091 0.62464034212269 0.131198685408586 miRNAWalker2_validate;miRTarBase;miRanda -0.237799286777961 0.000859583563159798 NA NA NA hsa-let-7a-3p CCND2 0.503048155002889 0.0411145454335299 -0.495732246530821 0.299995013548082 mirMAP -0.539007488034469 9.58303749078928e-05 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7b-3p CCND2 0.21838629112113 0.296038413622566 -0.495732246530821 0.299995013548082 mirMAP -0.458425126620734 0.00587678366196967 NA NA NA hsa-miR-106b-5p CCND2 1.70863907461894 2.04074794107142e-08 -0.495732246530821 0.299995013548082 miRNAWalker2_validate;miRTarBase;miRNATAP -0.420111135029172 8.79445971678554e-05 NA NA NA hsa-miR-130b-5p CCND2 0.701350393759937 0.0510142718395002 -0.495732246530821 0.299995013548082 mirMAP -0.393986053261913 2.48361314637284e-05 NA NA NA hsa-miR-141-3p CCND2 1.45548825076434 0.00115958850961764 -0.495732246530821 0.299995013548082 MirTarget;TargetScan -0.213829265059233 0.00435932519246045 NA NA NA hsa-miR-15b-5p CCND2 1.62046407540723 5.42152621571078e-09 -0.495732246530821 0.299995013548082 miRNATAP -0.436574112059407 0.000206222006606723 NA NA NA hsa-miR-16-2-3p CCND2 1.8048179609245 2.83095715136409e-09 -0.495732246530821 0.299995013548082 mirMAP -0.54923627359894 1.83952504317926e-07 NA NA NA hsa-miR-16-5p CCND2 1.00515772948091 5.33912942007619e-06 -0.495732246530821 0.299995013548082 miRNAWalker2_validate;miRNATAP -0.666404634405191 9.74095569654959e-06 NA NA NA hsa-miR-181a-2-3p CCND2 0.901732254836667 0.000830304681396734 -0.495732246530821 0.299995013548082 mirMAP -0.381747755391939 0.00236274066260059 NA NA NA hsa-miR-182-5p CCND2 0.887369486030646 0.0310640781418789 -0.495732246530821 0.299995013548082 miRNAWalker2_validate;miRTarBase;miRNATAP -0.320494097434122 8.56279904949731e-05 NA NA NA hsa-miR-183-5p CCND2 1.65900927871187 0.000522025364980187 -0.495732246530821 0.299995013548082 miRNATAP -0.293018901580787 2.29962975856133e-05 NA NA NA hsa-miR-19b-3p CCND2 0.759818275708988 0.00652779573186786 -0.495732246530821 0.299995013548082 miRNAWalker2_validate;MirTarget;miRNATAP -0.321137891620492 0.0085283453454723 NA NA NA hsa-miR-21-3p CCND2 1.75245546017565 2.36505176715025e-10 -0.495732246530821 0.299995013548082 mirMAP -0.330852598235875 0.00510140773909108 NA NA NA hsa-miR-224-3p CCND2 1.52422171450716 0.00650463542340912 -0.495732246530821 0.299995013548082 mirMAP -0.268591207673576 3.7771965471366e-05 NA NA NA hsa-miR-26b-5p CCND2 -0.301646326928219 0.160081421968103 -0.495732246530821 0.299995013548082 mirMAP;miRNATAP -0.575426727790569 0.00033543015515606 NA NA NA hsa-miR-301a-3p CCND2 1.44721900431161 6.35068481036652e-06 -0.495732246530821 0.299995013548082 miRNAWalker2_validate -0.383757128016972 0.0002041077399091 NA NA NA hsa-miR-3065-3p CCND2 -1.03551124329864 0.0218397494946288 -0.495732246530821 0.299995013548082 MirTarget;miRNATAP -0.202763155868079 0.00685463393219998 NA NA NA hsa-miR-3065-5p CCND2 -0.241623656423063 0.633116553078159 -0.495732246530821 0.299995013548082 mirMAP -0.236172852888811 0.000570437819651464 NA NA NA hsa-miR-424-5p CCND2 1.08509868581983 0.000420473853818268 -0.495732246530821 0.299995013548082 miRNATAP -0.393741408465626 0.000302491529945387 NA NA NA hsa-miR-429 CCND2 1.40182602301928 0.00900426780286475 -0.495732246530821 0.299995013548082 miRNATAP -0.193697975832347 0.00200087926732012 NA NA NA hsa-miR-450b-5p CCND2 0.46157963033014 0.13273722727895 -0.495732246530821 0.299995013548082 MirTarget;PITA;miRNATAP -0.319300360536976 0.00413356428949538 NA NA NA hsa-miR-590-3p CCND2 1.11654983899947 0.000160782154924864 -0.495732246530821 0.299995013548082 miRanda;mirMAP -0.332566390160307 0.00348233876262983 NA NA NA hsa-miR-590-5p CCND2 1.04171442093217 0.000272475544954865 -0.495732246530821 0.299995013548082 mirMAP -0.40586994965179 0.000547583893303904 NA NA NA hsa-miR-9-3p CCND2 0.330346058941473 0.541111939982661 -0.495732246530821 0.299995013548082 MirTarget;mirMAP;miRNATAP -0.190791407012111 0.00360684983294818 NA NA NA hsa-miR-93-5p CCND2 1.7515174434778 1.59386482413883e-08 -0.495732246530821 0.299995013548082 miRNATAP -0.321341054229317 0.00244079386586045 NA NA NA hsa-miR-96-5p CCND2 1.14243043653372 0.00942969392739105 -0.495732246530821 0.299995013548082 TargetScan;miRNATAP -0.334672732851839 2.58915737933556e-05 NA NA NA hsa-miR-96-5p CCND3 1.14243043653372 0.00942969392739105 0.0356607593991125 0.883520357560836 TargetScan -0.119818202566509 0.00327749541512401 NA NA NA hsa-miR-125b-5p CCNE1 -0.509303501421334 0.133265526313161 2.19321666957752 7.58574979891593e-09 miRNAWalker2_validate -0.26234320685223 0.00155046398906082 NA NA NA hsa-miR-195-5p CCNE1 -0.907998841926297 0.00150511564650591 2.19321666957752 7.58574979891593e-09 miRNAWalker2_validate;MirTarget;miRNATAP -0.431213874492418 7.80520066718325e-06 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-497-5p CCNE1 -0.801030912431774 0.00360386743876612 2.19321666957752 7.58574979891593e-09 MirTarget;miRNATAP -0.428398960662757 2.16247264707644e-05 24112607;25909221;24909281 Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells;miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1 ;; breast cancer;lung cancer;cervical and endocervical cancer hsa-miR-26a-5p CCNE2 -0.384110714440647 0.0442498636014044 1.35587893076287 2.63917326776567e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.435562646712902 9.72974519873178e-05 24116110;21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression poor survival;progression pancreatic cancer;acute myeloid leukemia hsa-miR-30a-5p CCNE2 -1.71922855140016 3.20574349285256e-07 1.35587893076287 2.63917326776567e-06 miRNATAP -0.216731893468082 0.000339344793439292 NA NA NA hsa-miR-145-5p CDK4 -1.75133578902314 1.54965572197748e-05 1.15953651250859 6.32013674437628e-08 miRNAWalker2_validate;miRTarBase -0.128867203591511 0.00065492290615456 21092188 Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control lung squamous cell cancer hsa-miR-195-5p CDK4 -0.907998841926297 0.00150511564650591 1.15953651250859 6.32013674437628e-08 miRNAWalker2_validate;miRTarBase -0.160202666019046 0.00343668366819135 NA NA NA hsa-miR-101-3p CDK6 -0.451263906815861 0.0283387250173031 0.299248876757035 0.400797488709762 mirMAP -0.390880566201796 0.0017319791753036 NA NA NA hsa-miR-129-5p CDK6 -2.56914016541176 2.36237896095709e-06 0.299248876757035 0.400797488709762 miRNAWalker2_validate -0.131377486244208 0.00426734981945999 24055727 Interestingly we showed that cyclin dependent kinase 6 CDK6 a cell cycle-associated protein involved in G1-S transition was a target of miR-129 gastric cancer hsa-miR-30d-3p CDK6 -0.545113326540761 0.0433733076874155 0.299248876757035 0.400797488709762 mirMAP -0.279904118765617 0.00297854403213622 NA NA NA hsa-miR-30d-5p CDK6 -0.5492586056147 0.0140125082460125 0.299248876757035 0.400797488709762 mirMAP -0.442605862369401 9.48761181124052e-05 NA NA NA hsa-let-7d-5p CDKN1A 0.981733854788227 7.26366577706469e-07 -0.527054376093461 0.0994835075201721 MirTarget -0.396477553702672 0.000479683524112273 NA NA NA hsa-let-7g-5p CDKN1A 0.325297685027927 0.241142963826631 -0.527054376093461 0.0994835075201721 MirTarget -0.314745562281535 0.000125688268144105 NA NA NA hsa-let-7i-5p CDKN1A 0.798954594465461 2.99735653959449e-05 -0.527054376093461 0.0994835075201721 MirTarget -0.322641868184451 0.00701233652117083 NA NA NA hsa-miR-101-3p CDKN1A -0.451263906815861 0.0283387250173031 -0.527054376093461 0.0994835075201721 MirTarget -0.447896067740702 5.80221830113762e-05 NA NA NA hsa-miR-106b-5p CDKN1A 1.70863907461894 2.04074794107142e-08 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.319691088785281 7.24575207668053e-06 NA NA NA hsa-miR-146a-5p CDKN1A 1.82051649415508 2.03651725047679e-05 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate -0.181963416651094 0.000452608950605388 NA NA NA hsa-miR-17-5p CDKN1A 1.65862087862483 8.45603406215941e-08 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.261784540083651 0.000223281598813828 26482648;24989082 The low expressions of miR-17 and miR-92 families can maintain cisplatin resistance through the regulation of CDKN1A and RAD21;According to PicTar and Miranda algorithms which predicted CDKN1A p21 as a putative target of miR-17 a luciferase assay was performed and revealed that miR-17 directly targets the 3'-UTR of p21 mRNA drug resistance; lung squamous cell cancer;sarcoma hsa-miR-20a-5p CDKN1A 1.4503375861709 5.7813456424762e-07 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.31050980918024 4.24749867032784e-05 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex colon cancer hsa-miR-30b-3p CDKN1A -0.266398938200332 0.400847813143994 -0.527054376093461 0.0994835075201721 MirTarget -0.232429451010355 0.00125169502954217 NA NA NA hsa-miR-335-5p CDKN1A 1.59953351087307 5.56170899867314e-05 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate -0.323092043513641 2.937052662711e-09 NA NA NA hsa-miR-345-5p CDKN1A 1.83686164833727 1.1036889735857e-08 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate;miRTarBase;MirTarget -0.244264832927155 0.000326167065691554 NA NA NA hsa-miR-423-3p CDKN1A 0.817576939524592 0.000261533454265696 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate;miRTarBase -0.324900447056002 0.00137746661266851 NA NA NA hsa-miR-423-5p CDKN1A 0.832613878736338 0.000791321227103338 -0.527054376093461 0.0994835075201721 MirTarget -0.413612288167575 4.59123064989195e-06 NA NA NA hsa-miR-429 CDKN1A 1.40182602301928 0.00900426780286475 -0.527054376093461 0.0994835075201721 miRNATAP -0.134914410282826 0.00128436889666203 NA NA NA hsa-miR-93-5p CDKN1A 1.7515174434778 1.59386482413883e-08 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.319008304670668 5.03968506845812e-06 25633810 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC liver cancer hsa-miR-942-5p CDKN1A 1.90585138008274 3.11903311044863e-09 -0.527054376093461 0.0994835075201721 miRNAWalker2_validate -0.183830567960007 0.00704444870897519 NA NA NA hsa-miR-24-3p CDKN1B 1.08578167539644 6.18549359075268e-07 0.155949085500731 0.363773087578399 miRNAWalker2_validate;miRNATAP -0.146430073571543 0.00772254700341091 26847530;26044523 The biological significance of miR-24 expression in prostate cancer cells was assessed by a series of in vitro bioassays and the effect on proposed targets p27 CDKN1B and p16 CDK2NA was investigated;With the bioinformatic method we further identified that p27Kip1 is a direct target of miR-24-3p and its protein level was negatively regulated by miR-24-3p ; prostate cancer;breast cancer hsa-miR-199a-3p CHAD 0.85352674491639 0.000360518331912285 -3.17249824269304 6.07283300839428e-08 MirTarget;miRNATAP -0.614963373093793 0.000618571114269895 NA NA NA hsa-miR-199b-3p CHAD 0.860968252593043 0.00032297319521262 -3.17249824269304 6.07283300839428e-08 MirTarget -0.616256887281077 0.000594415205006539 NA NA NA hsa-miR-222-5p CHAD 1.87968474330782 1.11743009485711e-06 -3.17249824269304 6.07283300839428e-08 MirTarget -0.287976562676932 0.00830472364657047 NA NA NA hsa-miR-27a-3p CHRM1 1.29886998470345 2.68986118553486e-08 -2.27679541268868 0.00337641999998935 miRNATAP -0.972211148414849 2.50213071580248e-05 NA NA NA hsa-miR-10b-3p CHRM2 0.773619331000039 0.0076628900286607 -3.76306686304791 3.81688839697398e-07 mirMAP -0.598526154871475 0.00138371335119429 NA NA NA hsa-miR-126-5p CHRM2 0.41765430251855 0.0753161203651532 -3.76306686304791 3.81688839697398e-07 mirMAP -0.745424619919359 0.00145767151662488 NA NA NA hsa-miR-142-5p CHRM2 1.55592486377018 6.69269968016779e-06 -3.76306686304791 3.81688839697398e-07 mirMAP -0.682959517862002 6.95665623439316e-06 NA NA NA hsa-miR-16-1-3p CHRM2 1.43227522002564 3.70920454953168e-08 -3.76306686304791 3.81688839697398e-07 mirMAP -0.894107857977769 8.41204668924139e-06 NA NA NA hsa-miR-17-5p CHRM2 1.65862087862483 8.45603406215941e-08 -3.76306686304791 3.81688839697398e-07 TargetScan -0.966355600790069 4.90864994026324e-09 NA NA NA hsa-miR-186-5p CHRM2 0.149964130725901 0.434709542998771 -3.76306686304791 3.81688839697398e-07 mirMAP -0.866669309698802 0.00291133773215815 NA NA NA hsa-miR-29b-1-5p CHRM2 0.606560155953522 0.116355599574769 -3.76306686304791 3.81688839697398e-07 mirMAP -0.400153700372101 0.00463450777297075 NA NA NA hsa-miR-335-3p CHRM2 2.5197689063267 2.20084506976733e-09 -3.76306686304791 3.81688839697398e-07 mirMAP -0.628410745528955 1.97051668590541e-07 NA NA NA hsa-miR-335-5p CHRM2 1.59953351087307 5.56170899867314e-05 -3.76306686304791 3.81688839697398e-07 miRNAWalker2_validate -0.630239513141886 1.8779876598422e-06 NA NA NA hsa-miR-429 CHRM2 1.40182602301928 0.00900426780286475 -3.76306686304791 3.81688839697398e-07 miRanda -0.407744032750481 4.06817625857519e-05 NA NA NA hsa-miR-501-5p CHRM2 0.266919328110625 0.454779001968586 -3.76306686304791 3.81688839697398e-07 mirMAP -0.524578611339304 0.000571778910096432 NA NA NA hsa-miR-577 CHRM2 0.911619788986754 0.2256062124148 -3.76306686304791 3.81688839697398e-07 mirMAP -0.301453180044991 3.63142196899493e-05 NA NA NA hsa-miR-590-3p CHRM2 1.11654983899947 0.000160782154924864 -3.76306686304791 3.81688839697398e-07 mirMAP -0.858075161167805 1.59044156991828e-06 NA NA NA hsa-miR-152-3p CHUK 0.436002345388935 0.161701199884702 -0.111597771177896 0.436110414435051 MirTarget -0.173337618013613 3.78615463498576e-08 NA NA NA hsa-miR-195-5p CHUK -0.907998841926297 0.00150511564650591 -0.111597771177896 0.436110414435051 miRNAWalker2_validate;MirTarget -0.133199766126432 0.000124702259663161 NA NA NA hsa-miR-23a-3p CHUK 1.10685926969665 3.16223452471768e-08 -0.111597771177896 0.436110414435051 MirTarget -0.16996459977061 0.000556739825154491 NA NA NA hsa-miR-23b-3p CHUK -0.286465516491361 0.18664668472995 -0.111597771177896 0.436110414435051 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.186735010864747 6.42002077885917e-05 NA NA NA hsa-miR-342-3p CHUK 0.318119432680668 0.269150960124243 -0.111597771177896 0.436110414435051 miRanda -0.186912661037413 4.74504057766316e-08 NA NA NA hsa-miR-497-5p CHUK -0.801030912431774 0.00360386743876612 -0.111597771177896 0.436110414435051 MirTarget -0.109322835458534 0.00272843002977532 NA NA NA hsa-miR-107 COL1A1 0.904627575346218 4.67936495073904e-05 2.44985066495142 5.43143580547488e-06 PITA;miRanda -0.531214508146817 0.00257806895179595 NA NA NA hsa-miR-126-5p COL1A1 0.41765430251855 0.0753161203651532 2.44985066495142 5.43143580547488e-06 miRNATAP -0.753090862100838 6.39436351324928e-06 NA NA NA hsa-miR-150-5p COL1A1 0.147461377429675 0.753719621305461 2.44985066495142 5.43143580547488e-06 miRNATAP -0.476421516526796 3.83003056172264e-09 NA NA NA hsa-miR-29a-3p COL1A1 -0.113012156986374 0.615005009685815 2.44985066495142 5.43143580547488e-06 miRNATAP -0.699062359226651 7.45880252084221e-05 NA NA NA hsa-miR-29b-3p COL1A1 -0.230693226193598 0.367461626035234 2.44985066495142 5.43143580547488e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.577325260819259 0.000182556163100156 NA NA NA hsa-miR-29c-3p COL1A1 -1.62454036584589 5.38376515586029e-07 2.44985066495142 5.43143580547488e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.673130166732297 3.81716703219766e-09 NA NA NA hsa-miR-30a-3p COL1A1 -1.73205137750899 3.2425754511091e-07 2.44985066495142 5.43143580547488e-06 mirMAP -0.435142164103091 9.83389874226104e-05 NA NA NA hsa-miR-30b-3p COL1A1 -0.266398938200332 0.400847813143994 2.44985066495142 5.43143580547488e-06 miRNATAP -0.603741825545753 7.66476858464093e-07 NA NA NA hsa-miR-30d-3p COL1A1 -0.545113326540761 0.0433733076874155 2.44985066495142 5.43143580547488e-06 mirMAP -0.731086191946979 3.32575296280113e-07 NA NA NA hsa-miR-30e-3p COL1A1 -0.913131357083321 7.29096855615228e-06 2.44985066495142 5.43143580547488e-06 mirMAP -0.872215464994674 4.10971398434479e-06 NA NA NA hsa-miR-330-3p COL1A1 0.798460296022179 0.00746538156533435 2.44985066495142 5.43143580547488e-06 mirMAP -0.369102192026523 0.00504860507912315 NA NA NA hsa-miR-338-3p COL1A1 -0.959276231066179 0.0191473351014091 2.44985066495142 5.43143580547488e-06 miRanda;miRNATAP -0.477451368770203 3.13792963252951e-07 NA NA NA hsa-miR-361-3p COL1A1 -0.126462931388735 0.566052688733137 2.44985066495142 5.43143580547488e-06 PITA -0.724495257845556 5.692363025982e-05 NA NA NA hsa-miR-532-3p COL1A1 0.552364451472481 0.0975490365586023 2.44985066495142 5.43143580547488e-06 PITA;miRNATAP -0.402588648619499 0.00061988226019049 NA NA NA hsa-miR-577 COL1A1 0.911619788986754 0.2256062124148 2.44985066495142 5.43143580547488e-06 MirTarget;PITA;miRNATAP -0.160048539032184 0.00264866530502343 NA NA NA hsa-miR-625-5p COL1A1 0.537211086526376 0.203801009380384 2.44985066495142 5.43143580547488e-06 MirTarget -0.305320767653657 0.0010453631778075 NA NA NA hsa-miR-26a-5p COL1A2 -0.384110714440647 0.0442498636014044 1.30228102636561 0.00792817626515194 MirTarget;miRNATAP -0.593262371155885 0.00159961873628197 NA NA NA hsa-miR-26b-5p COL1A2 -0.301646326928219 0.160081421968103 1.30228102636561 0.00792817626515194 MirTarget;miRNATAP -0.702153351679571 2.01262856430147e-05 NA NA NA hsa-miR-29a-3p COL1A2 -0.113012156986374 0.615005009685815 1.30228102636561 0.00792817626515194 miRNATAP -0.695746281077265 9.46182551434364e-06 NA NA NA hsa-miR-29b-3p COL1A2 -0.230693226193598 0.367461626035234 1.30228102636561 0.00792817626515194 miRNATAP -0.576142965287313 2.74551822471994e-05 NA NA NA hsa-miR-29c-3p COL1A2 -1.62454036584589 5.38376515586029e-07 1.30228102636561 0.00792817626515194 miRNAWalker2_validate;miRTarBase;miRNATAP -0.533282042743308 2.40283453559017e-07 NA NA NA hsa-miR-30a-3p COL1A2 -1.73205137750899 3.2425754511091e-07 1.30228102636561 0.00792817626515194 MirTarget -0.261749989138394 0.00958487120849857 NA NA NA hsa-miR-30d-3p COL1A2 -0.545113326540761 0.0433733076874155 1.30228102636561 0.00792817626515194 MirTarget -0.650804727216266 3.83141859188195e-07 NA NA NA hsa-miR-30e-3p COL1A2 -0.913131357083321 7.29096855615228e-06 1.30228102636561 0.00792817626515194 MirTarget -0.711794987349663 2.89454881388966e-05 NA NA NA hsa-miR-32-3p COL1A2 0.583525764322974 0.11837203008551 1.30228102636561 0.00792817626515194 miRNATAP -0.366111733254426 0.000518801351475772 NA NA NA hsa-miR-32-5p COL1A2 0.415247682945382 0.106458022460373 1.30228102636561 0.00792817626515194 MirTarget;miRNATAP -0.571753341358994 2.75777955168215e-05 NA NA NA hsa-miR-330-5p COL1A2 0.488365986827708 0.0512207630808233 1.30228102636561 0.00792817626515194 miRanda -0.454906942738119 0.00128029535393626 NA NA NA hsa-miR-33a-3p COL1A2 0.347011402017138 0.321709379745392 1.30228102636561 0.00792817626515194 MirTarget -0.406379427250253 0.00011117706081928 NA NA NA hsa-miR-3934-5p COL1A2 0.861517283620376 0.0208987307869276 1.30228102636561 0.00792817626515194 MirTarget -0.261395186154855 0.00582939121407593 NA NA NA hsa-miR-500a-5p COL1A2 0.00337014556047865 0.992120109131868 1.30228102636561 0.00792817626515194 miRNATAP -0.280016860674177 0.00692983704762767 NA NA NA hsa-miR-7-1-3p COL1A2 0.709309110750947 0.0412301737463194 1.30228102636561 0.00792817626515194 mirMAP -0.407746831884911 4.59102634248576e-05 NA NA NA hsa-miR-92a-3p COL1A2 1.2209325870225 6.8757197708107e-06 1.30228102636561 0.00792817626515194 MirTarget;miRNATAP -0.330041735970185 0.00983863964842055 NA NA NA hsa-miR-148a-3p COL4A1 -1.53721533763578 3.55533747293117e-05 1.07015267715433 0.00177164289889366 miRNATAP -0.186981085227601 0.00399162270521003 NA NA NA hsa-miR-29a-3p COL4A1 -0.113012156986374 0.615005009685815 1.07015267715433 0.00177164289889366 miRNAWalker2_validate;miRTarBase;miRNATAP -0.338222302444329 0.00238657829982258 NA NA NA hsa-miR-29c-3p COL4A1 -1.62454036584589 5.38376515586029e-07 1.07015267715433 0.00177164289889366 miRNAWalker2_validate;miRTarBase;miRNATAP -0.358750776944718 7.27042930902539e-07 NA NA NA hsa-miR-3065-5p COL4A1 -0.241623656423063 0.633116553078159 1.07015267715433 0.00177164289889366 miRNATAP -0.173108710122076 0.000474086069880795 NA NA NA hsa-miR-99a-5p COL4A1 -1.06045199862251 0.0178432627965381 1.07015267715433 0.00177164289889366 miRNAWalker2_validate -0.280806157088145 1.33786013959461e-07 NA NA NA hsa-miR-29a-3p COL4A2 -0.113012156986374 0.615005009685815 0.471547944261182 0.160274382484754 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.315899111924612 0.00351562435250479 NA NA NA hsa-miR-29b-3p COL4A2 -0.230693226193598 0.367461626035234 0.471547944261182 0.160274382484754 miRTarBase;MirTarget;miRNATAP -0.277335098504772 0.00330580195409516 NA NA NA hsa-miR-29c-3p COL4A2 -1.62454036584589 5.38376515586029e-07 0.471547944261182 0.160274382484754 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.2813336800449 7.64216441696144e-05 NA NA NA hsa-miR-106b-5p COL4A3 1.70863907461894 2.04074794107142e-08 -3.64913260885542 8.66219178119276e-06 MirTarget;miRNATAP -0.631633332402779 0.000851717902336075 NA NA NA hsa-miR-107 COL4A3 0.904627575346218 4.67936495073904e-05 -3.64913260885542 8.66219178119276e-06 miRanda -0.711727474181926 0.00813805268090371 NA NA NA hsa-miR-135b-5p COL4A3 4.09156383496059 1.32294295002438e-12 -3.64913260885542 8.66219178119276e-06 MirTarget -0.424397246243816 9.47486908850111e-06 NA NA NA hsa-miR-15b-3p COL4A3 1.75738933306437 3.00554466232543e-08 -3.64913260885542 8.66219178119276e-06 mirMAP -0.946287000626126 1.05427351116557e-07 NA NA NA hsa-miR-16-2-3p COL4A3 1.8048179609245 2.83095715136409e-09 -3.64913260885542 8.66219178119276e-06 mirMAP -0.879196999132746 2.37632515660686e-06 NA NA NA hsa-miR-17-5p COL4A3 1.65862087862483 8.45603406215941e-08 -3.64913260885542 8.66219178119276e-06 MirTarget;TargetScan;miRNATAP -0.931915817327141 3.77037217173535e-07 NA NA NA hsa-miR-200c-3p COL4A3 1.28185685499076 0.00369777635539177 -3.64913260885542 8.66219178119276e-06 miRNATAP -0.484552323058469 0.000277893441899746 NA NA NA hsa-miR-20a-5p COL4A3 1.4503375861709 5.7813456424762e-07 -3.64913260885542 8.66219178119276e-06 MirTarget;miRNATAP -0.763634756322824 0.000132563088831986 NA NA NA hsa-miR-335-3p COL4A3 2.5197689063267 2.20084506976733e-09 -3.64913260885542 8.66219178119276e-06 mirMAP -0.517094155389913 0.000125623555509644 NA NA NA hsa-miR-33a-3p COL4A3 0.347011402017138 0.321709379745392 -3.64913260885542 8.66219178119276e-06 MirTarget -0.572799418625223 0.00146084350662483 NA NA NA hsa-miR-370-3p COL4A3 1.02953147036298 0.00666384291823188 -3.64913260885542 8.66219178119276e-06 MirTarget -0.489900951152884 0.00172776219796368 NA NA NA hsa-miR-3922-3p COL4A3 1.33252322927569 0.000665307190249975 -3.64913260885542 8.66219178119276e-06 MirTarget -0.597520968496097 0.000614003096135785 NA NA NA hsa-miR-429 COL4A3 1.40182602301928 0.00900426780286475 -3.64913260885542 8.66219178119276e-06 miRanda;miRNATAP -0.339009358310608 0.00209911791117294 NA NA NA hsa-miR-542-3p COL4A3 0.757649022262991 0.00210575463285599 -3.64913260885542 8.66219178119276e-06 miRanda -0.643972167467204 0.00823753474455879 NA NA NA hsa-miR-654-5p COL4A3 0.972762125372776 0.00586241685907749 -3.64913260885542 8.66219178119276e-06 MirTarget -0.499450157683422 0.00462258152898612 NA NA NA hsa-miR-93-3p COL4A3 1.88964231421793 1.80075645722786e-08 -3.64913260885542 8.66219178119276e-06 miRNATAP -0.684910463882908 5.81881940214861e-05 NA NA NA hsa-miR-93-5p COL4A3 1.7515174434778 1.59386482413883e-08 -3.64913260885542 8.66219178119276e-06 MirTarget;miRNATAP -0.698488579611954 0.000162422752440628 NA NA NA hsa-miR-944 COL4A3 3.33123095809751 0.0177835044930391 -3.64913260885542 8.66219178119276e-06 mirMAP -0.154649078016413 0.00200425066684778 NA NA NA hsa-let-7b-3p COL4A4 0.21838629112113 0.296038413622566 -2.06628373905498 0.00263849849397833 mirMAP -0.939187417588921 8.67877778110397e-05 NA NA NA hsa-let-7f-1-3p COL4A4 1.28704406797397 1.17954701106157e-06 -2.06628373905498 0.00263849849397833 mirMAP -0.678824150677604 0.000188390826685468 NA NA NA hsa-miR-130b-3p COL4A4 1.32714007211004 4.78676252285191e-05 -2.06628373905498 0.00263849849397833 mirMAP -0.535542842766831 0.000301904614574943 NA NA NA hsa-miR-15b-3p COL4A4 1.75738933306437 3.00554466232543e-08 -2.06628373905498 0.00263849849397833 MirTarget -0.641643397648505 1.62696867279298e-05 NA NA NA hsa-miR-181a-2-3p COL4A4 0.901732254836667 0.000830304681396734 -2.06628373905498 0.00263849849397833 MirTarget -0.503823524811902 0.00583458154957682 NA NA NA hsa-miR-182-5p COL4A4 0.887369486030646 0.0310640781418789 -2.06628373905498 0.00263849849397833 MirTarget -0.509471066340159 1.58191928479017e-05 NA NA NA hsa-miR-203a-3p COL4A4 1.44736908507496 0.0394116388736904 -2.06628373905498 0.00263849849397833 MirTarget -0.483453933728991 2.11745021896491e-13 NA NA NA hsa-miR-224-3p COL4A4 1.52422171450716 0.00650463542340912 -2.06628373905498 0.00263849849397833 mirMAP -0.453103454234165 1.40096871415376e-06 NA NA NA hsa-miR-23a-3p COL4A4 1.10685926969665 3.16223452471768e-08 -2.06628373905498 0.00263849849397833 miRNATAP -1.48568940718866 1.96538800268654e-10 NA NA NA hsa-miR-299-5p COL4A4 -0.173288988251251 0.638938431622539 -2.06628373905498 0.00263849849397833 miRNATAP -0.500748190663107 0.000220811096931536 NA NA NA hsa-miR-301a-3p COL4A4 1.44721900431161 6.35068481036652e-06 -2.06628373905498 0.00263849849397833 mirMAP -0.446334085200626 0.00312936093150876 NA NA NA hsa-miR-33a-3p COL4A4 0.347011402017138 0.321709379745392 -2.06628373905498 0.00263849849397833 mirMAP -0.442563169551 0.00296471054312613 NA NA NA hsa-miR-34c-3p COL4A4 2.25273698056457 9.06191072601281e-05 -2.06628373905498 0.00263849849397833 mirMAP -0.324049260007693 0.000125793101046701 NA NA NA hsa-miR-34c-5p COL4A4 2.20632574870337 0.000379662996168678 -2.06628373905498 0.00263849849397833 miRanda -0.23792742804241 0.00250503685290009 NA NA NA hsa-miR-576-5p COL4A4 0.625714137488957 0.0417100301848969 -2.06628373905498 0.00263849849397833 PITA -0.444193361400833 0.00589632246742232 NA NA NA hsa-miR-629-3p COL4A4 1.40326397107309 9.7803063526732e-05 -2.06628373905498 0.00263849849397833 MirTarget;miRNATAP -0.441219406306061 0.00105271374184836 NA NA NA hsa-miR-944 COL4A4 3.33123095809751 0.0177835044930391 -2.06628373905498 0.00263849849397833 PITA;mirMAP;miRNATAP -0.198677158995097 9.87316116085981e-07 NA NA NA hsa-let-7f-5p COL4A5 0.634633924115866 0.0344982923411787 -1.35701903974169 0.0294975709997557 miRNATAP -0.519206682678803 0.00045496733646567 NA NA NA hsa-let-7g-5p COL4A5 0.325297685027927 0.241142963826631 -1.35701903974169 0.0294975709997557 miRNATAP -0.798598486928009 4.70418265435984e-07 NA NA NA hsa-miR-29a-3p COL4A5 -0.113012156986374 0.615005009685815 -1.35701903974169 0.0294975709997557 miRNATAP -1.00287223527023 3.87410569403416e-07 NA NA NA hsa-miR-29b-3p COL4A5 -0.230693226193598 0.367461626035234 -1.35701903974169 0.0294975709997557 miRNATAP -0.859104548769942 6.43862433611514e-07 NA NA NA hsa-miR-335-5p COL4A5 1.59953351087307 5.56170899867314e-05 -1.35701903974169 0.0294975709997557 miRNAWalker2_validate -0.542052878698826 5.11361886305292e-07 NA NA NA hsa-miR-338-5p COL4A5 -1.19659203838734 0.0100316010080496 -1.35701903974169 0.0294975709997557 PITA;miRNATAP -0.439381512794696 2.60094450388208e-06 NA NA NA hsa-miR-429 COL4A5 1.40182602301928 0.00900426780286475 -1.35701903974169 0.0294975709997557 miRanda -0.45874547537641 8.6053144159776e-09 NA NA NA hsa-miR-29a-3p COL4A6 -0.113012156986374 0.615005009685815 -1.76074061564177 0.0350594342235256 miRNATAP -0.756215157796074 0.00525583562071523 NA NA NA hsa-miR-29b-3p COL4A6 -0.230693226193598 0.367461626035234 -1.76074061564177 0.0350594342235256 miRNATAP -0.879877444125398 0.000174837833483554 NA NA NA hsa-miR-326 COL4A6 -0.429748586406214 0.2629894124021 -1.76074061564177 0.0350594342235256 miRanda -0.591067914065894 0.000156019566158833 NA NA NA hsa-miR-429 COL4A6 1.40182602301928 0.00900426780286475 -1.76074061564177 0.0350594342235256 miRanda;miRNATAP -0.667785673717758 2.87348388485953e-10 NA NA NA hsa-miR-335-5p COL6A1 1.59953351087307 5.56170899867314e-05 0.110728324815048 0.789940358644198 miRNAWalker2_validate -0.414842566564086 4.27725020298826e-09 NA NA NA hsa-miR-29a-3p COL6A3 -0.113012156986374 0.615005009685815 1.02093506340636 0.0267561221463991 MirTarget;miRNATAP -0.551393665476538 0.00020031413623541 NA NA NA hsa-miR-29b-3p COL6A3 -0.230693226193598 0.367461626035234 1.02093506340636 0.0267561221463991 MirTarget;miRNATAP -0.448628437956652 0.000539956200269006 NA NA NA hsa-miR-29c-3p COL6A3 -1.62454036584589 5.38376515586029e-07 1.02093506340636 0.0267561221463991 MirTarget;miRNATAP -0.400178051461403 4.42156776829868e-05 NA NA NA hsa-miR-320b COL6A3 1.11183660885284 0.000497971211648503 1.02093506340636 0.0267561221463991 miRanda -0.315115087895812 0.00202228945844703 NA NA NA hsa-miR-320c COL6A3 0.455072851945474 0.240613785444485 1.02093506340636 0.0267561221463991 miRanda -0.28805593132866 0.00346415508904016 NA NA NA hsa-miR-330-3p COL6A3 0.798460296022179 0.00746538156533435 1.02093506340636 0.0267561221463991 miRNATAP -0.429666016001509 8.41371579350842e-05 NA NA NA hsa-miR-362-3p COL6A3 -0.0349414695893027 0.913780708043777 1.02093506340636 0.0267561221463991 miRanda -0.286807999666134 0.00540034987407448 NA NA NA hsa-miR-429 COL6A3 1.40182602301928 0.00900426780286475 1.02093506340636 0.0267561221463991 miRNATAP -0.28975163575323 1.16998966961136e-06 NA NA NA hsa-miR-590-3p COL6A3 1.11654983899947 0.000160782154924864 1.02093506340636 0.0267561221463991 miRanda -0.31755010155061 0.00397506807593211 NA NA NA hsa-miR-186-5p COL6A6 0.149964130725901 0.434709542998771 -0.977246167109212 0.0981764777025335 MirTarget -0.594548319982905 0.0085005509155893 NA NA NA hsa-miR-335-5p COL6A6 1.59953351087307 5.56170899867314e-05 -0.977246167109212 0.0981764777025335 miRNAWalker2_validate -0.406188660611035 8.44581001599318e-05 NA NA NA hsa-miR-375 COL6A6 -2.94506033785642 0.00570147601654791 -0.977246167109212 0.0981764777025335 miRanda -0.149511227213941 0.000111415097930031 NA NA NA hsa-miR-429 COL6A6 1.40182602301928 0.00900426780286475 -0.977246167109212 0.0981764777025335 miRanda -0.231137377248269 0.00293748201768021 NA NA NA hsa-miR-486-5p COL6A6 -0.627607241830911 0.155274583521138 -0.977246167109212 0.0981764777025335 miRanda;miRNATAP -0.253892292301689 0.00780140399828789 NA NA NA hsa-miR-501-5p COL6A6 0.266919328110625 0.454779001968586 -0.977246167109212 0.0981764777025335 mirMAP -0.386057309438727 0.0010763337094352 NA NA NA hsa-miR-532-3p COL6A6 0.552364451472481 0.0975490365586023 -0.977246167109212 0.0981764777025335 MirTarget -0.546169100705274 1.23188709108485e-05 NA NA NA hsa-miR-577 COL6A6 0.911619788986754 0.2256062124148 -0.977246167109212 0.0981764777025335 MirTarget;mirMAP -0.174851199495273 0.00218427011485961 NA NA NA hsa-let-7a-3p COL9A1 0.503048155002889 0.0411145454335299 -0.411562805744093 0.662262409598321 mirMAP -1.23912075261826 4.49614100935844e-06 NA NA NA hsa-let-7b-3p COL9A1 0.21838629112113 0.296038413622566 -0.411562805744093 0.662262409598321 mirMAP -1.17133074929576 0.00032053982209041 NA NA NA hsa-miR-944 COL9A1 3.33123095809751 0.0177835044930391 -0.411562805744093 0.662262409598321 mirMAP -0.464090204459783 1.30657210798638e-19 NA NA NA hsa-miR-26a-5p CREB1 -0.384110714440647 0.0442498636014044 0.124743144945682 0.32856474376221 MirTarget;mirMAP -0.155987296601021 0.0010664255905594 NA NA NA hsa-miR-28-5p CREB1 -0.238617853755144 0.167318538669818 0.124743144945682 0.32856474376221 PITA;miRNATAP -0.147559159256891 0.00575694224457579 NA NA NA hsa-miR-340-5p CREB1 -0.164941927483643 0.529910509321278 0.124743144945682 0.32856474376221 MirTarget -0.123359396558221 0.000307244084983214 NA NA NA hsa-miR-342-5p CREB3L1 0.692955062695486 0.030998736359949 -0.396189213225031 0.586974303203149 MirTarget -0.500715372803653 0.00190079494829686 NA NA NA hsa-miR-34c-5p CREB3L1 2.20632574870337 0.000379662996168678 -0.396189213225031 0.586974303203149 miRanda;miRNATAP -0.532702247483889 1.44725897777682e-11 NA NA NA hsa-let-7d-5p CREB3L2 0.981733854788227 7.26366577706469e-07 -0.668833373430425 0.00221964545349886 mirMAP -0.406775744513804 1.01697720499517e-07 NA NA NA hsa-miR-106b-5p CREB3L2 1.70863907461894 2.04074794107142e-08 -0.668833373430425 0.00221964545349886 mirMAP -0.208364243477158 2.18550358691881e-05 NA NA NA hsa-miR-128-3p CREB3L2 0.98280381420517 5.77641850797209e-05 -0.668833373430425 0.00221964545349886 MirTarget -0.204039601282248 0.00130065120307896 NA NA NA hsa-miR-141-3p CREB3L2 1.45548825076434 0.00115958850961764 -0.668833373430425 0.00221964545349886 MirTarget -0.150855555640671 8.97786803904983e-06 NA NA NA hsa-miR-16-5p CREB3L2 1.00515772948091 5.33912942007619e-06 -0.668833373430425 0.00221964545349886 miRNAWalker2_validate -0.271580744372545 9.6693507330557e-05 NA NA NA hsa-miR-17-5p CREB3L2 1.65862087862483 8.45603406215941e-08 -0.668833373430425 0.00221964545349886 mirMAP -0.191297274812992 8.29376142063852e-05 NA NA NA hsa-miR-182-5p CREB3L2 0.887369486030646 0.0310640781418789 -0.668833373430425 0.00221964545349886 mirMAP -0.139433364705126 0.000207909569868532 NA NA NA hsa-miR-185-5p CREB3L2 1.14351510556643 1.07346945085714e-08 -0.668833373430425 0.00221964545349886 MirTarget -0.201315775344525 0.00890692155283303 NA NA NA hsa-miR-18a-3p CREB3L2 2.35188582849667 1.39401350286321e-08 -0.668833373430425 0.00221964545349886 MirTarget -0.113046222803098 0.00185712838146599 NA NA NA hsa-miR-197-3p CREB3L2 0.888854270009261 0.000195183808214449 -0.668833373430425 0.00221964545349886 mirMAP -0.22781057184897 0.000464238661512377 NA NA NA hsa-miR-1976 CREB3L2 0.923172654386147 0.000118514313506673 -0.668833373430425 0.00221964545349886 MirTarget -0.24050654580534 0.000193086300155857 NA NA NA hsa-miR-20a-5p CREB3L2 1.4503375861709 5.7813456424762e-07 -0.668833373430425 0.00221964545349886 mirMAP -0.171488916132038 0.00109318594432379 NA NA NA hsa-miR-24-3p CREB3L2 1.08578167539644 6.18549359075268e-07 -0.668833373430425 0.00221964545349886 miRNATAP -0.37834318833872 4.15453798183528e-08 NA NA NA hsa-miR-3065-5p CREB3L2 -0.241623656423063 0.633116553078159 -0.668833373430425 0.00221964545349886 mirMAP -0.125349983124031 6.37328823328634e-05 NA NA NA hsa-miR-429 CREB3L2 1.40182602301928 0.00900426780286475 -0.668833373430425 0.00221964545349886 miRNATAP -0.11772263709826 3.71789314909654e-05 NA NA NA hsa-miR-92a-3p CREB3L2 1.2209325870225 6.8757197708107e-06 -0.668833373430425 0.00221964545349886 miRNAWalker2_validate;MirTarget;miRNATAP -0.227685000195104 5.04127571776151e-05 NA NA NA hsa-miR-92b-3p CREB3L2 1.33518446513417 1.45350885391576e-06 -0.668833373430425 0.00221964545349886 MirTarget;miRNATAP -0.172765607389757 0.00176317488411282 NA NA NA hsa-miR-96-5p CREB3L2 1.14243043653372 0.00942969392739105 -0.668833373430425 0.00221964545349886 MirTarget;TargetScan;miRNATAP -0.136858422528235 0.000196392229169212 NA NA NA hsa-miR-98-5p CREB3L2 0.919961309193122 2.61963790596372e-05 -0.668833373430425 0.00221964545349886 mirMAP -0.28801757832628 4.3859301318205e-05 NA NA NA hsa-miR-199a-5p CREB3L3 0.371973504507027 0.232661597228763 1.05398617025979 0.377172453391992 mirMAP -1.33060199243415 7.14125053728245e-07 NA NA NA hsa-miR-199b-5p CREB3L3 0.124595928096068 0.678156859366405 1.05398617025979 0.377172453391992 mirMAP -0.832958527717256 0.00348457552282051 NA NA NA hsa-miR-107 CREB5 0.904627575346218 4.67936495073904e-05 -0.527118633469385 0.288811610681797 miRNATAP -0.536632297514158 0.000684929972696998 NA NA NA hsa-miR-10a-5p CREB5 -0.470861534765518 0.148803248989189 -0.527118633469385 0.288811610681797 miRNAWalker2_validate -0.337964881572183 0.0018548533878203 NA NA NA hsa-miR-200b-3p CREB5 0.974577911407732 0.0595020056914543 -0.527118633469385 0.288811610681797 TargetScan -0.187381737139558 0.00591194429999183 NA NA NA hsa-miR-212-3p CREB5 0.960352937108106 0.00133449812322732 -0.527118633469385 0.288811610681797 miRNATAP -0.333139590671995 0.00471231404219655 NA NA NA hsa-miR-30b-3p CREB5 -0.266398938200332 0.400847813143994 -0.527118633469385 0.288811610681797 MirTarget -0.339943233218617 0.00240706971679207 NA NA NA hsa-miR-30d-3p CREB5 -0.545113326540761 0.0433733076874155 -0.527118633469385 0.288811610681797 mirMAP -0.397739074753881 0.00252106050127048 NA NA NA hsa-miR-330-3p CREB5 0.798460296022179 0.00746538156533435 -0.527118633469385 0.288811610681797 MirTarget;mirMAP -0.361471312376371 0.00222408047290139 NA NA NA hsa-miR-335-3p CREB5 2.5197689063267 2.20084506976733e-09 -0.527118633469385 0.288811610681797 mirMAP -0.339181887320784 1.90788408774138e-05 NA NA NA hsa-miR-338-5p CREB5 -1.19659203838734 0.0100316010080496 -0.527118633469385 0.288811610681797 mirMAP -0.230874840232429 0.0021862942332567 NA NA NA hsa-miR-362-5p CREB5 -0.354508685915981 0.354912078595613 -0.527118633469385 0.288811610681797 PITA -0.239260421731925 0.00979545926384491 NA NA NA hsa-miR-429 CREB5 1.40182602301928 0.00900426780286475 -0.527118633469385 0.288811610681797 PITA;miRanda;miRNATAP -0.193841834697136 0.00294694158625616 NA NA NA hsa-miR-532-3p CREB5 0.552364451472481 0.0975490365586023 -0.527118633469385 0.288811610681797 miRNATAP -0.462067966039888 1.02990115264112e-05 NA NA NA hsa-miR-577 CREB5 0.911619788986754 0.2256062124148 -0.527118633469385 0.288811610681797 PITA;mirMAP;miRNATAP -0.129331197841495 0.00705881983075822 NA NA NA hsa-miR-7-1-3p CREB5 0.709309110750947 0.0412301737463194 -0.527118633469385 0.288811610681797 mirMAP -0.384281137621975 0.000139168905326472 NA NA NA hsa-miR-106a-5p CSF1 -0.173255688252641 0.642872703263671 -0.306013328429031 0.339617855573793 miRNATAP -0.170469263289726 0.00529326868395722 NA NA NA hsa-miR-128-3p CSF1 0.98280381420517 5.77641850797209e-05 -0.306013328429031 0.339617855573793 MirTarget -0.292799890513823 0.00151811395185712 22909061 By mutations in putative miRNA targets in CSF-1 mRNA 3'UTR we identified a common target for both miR-128 and miR-152; We have also found that both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro two major aspects of the metastatic potential of cancer cells; Our results provide the evidence for a mechanism by which miR-128 and miR-152 down-regulate CSF-1 an important regulator of ovarian cancer motility ovarian cancer hsa-miR-130b-3p CSF1 1.32714007211004 4.78676252285191e-05 -0.306013328429031 0.339617855573793 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.245937304619252 0.000313814821079298 22005523 CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system; CSF-1 expression was negatively associated with miR-130b level in ovarian tissues and cell lines; Luciferase assay validated CSF-1 is a direct target of miR-130b; Knock-down of CSF-1 sensitized ovarian cancer cells to anticancer drugs and could partially attenuate the resistance inducing effect of miR-130b inhibitors; Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1 and the silencing of miR-130b may be mediated by DNA methylation drug resistance ovarian cancer hsa-miR-15b-5p CSF1 1.62046407540723 5.42152621571078e-09 -0.306013328429031 0.339617855573793 miRNATAP -0.241835541353696 0.00223920403975309 NA NA NA hsa-miR-17-5p CSF1 1.65862087862483 8.45603406215941e-08 -0.306013328429031 0.339617855573793 TargetScan;miRNATAP -0.288380079977193 4.40947475236434e-05 NA NA NA hsa-miR-20a-5p CSF1 1.4503375861709 5.7813456424762e-07 -0.306013328429031 0.339617855573793 miRNATAP -0.284235533220314 0.000186701312465847 NA NA NA hsa-miR-23b-5p CSF1 0.608950043767916 0.0486466728330363 -0.306013328429031 0.339617855573793 MirTarget -0.256397065845335 0.000725420051962134 NA NA NA hsa-miR-301b-3p CSF1 1.10080095582241 0.0715568440482997 -0.306013328429031 0.339617855573793 MirTarget -0.156933717567782 0.00197124789187324 NA NA NA hsa-miR-429 CSF1 1.40182602301928 0.00900426780286475 -0.306013328429031 0.339617855573793 PITA;miRanda;miRNATAP -0.200936373891527 1.05202961632838e-06 NA NA NA hsa-miR-532-3p CSF1 0.552364451472481 0.0975490365586023 -0.306013328429031 0.339617855573793 MirTarget;PITA -0.182127653327354 0.00784442562115013 NA NA NA hsa-miR-940 CSF1 1.64406174271686 0.000690854900107004 -0.306013328429031 0.339617855573793 MirTarget;PITA;miRNATAP -0.195859539526611 0.000322515538656205 NA NA NA hsa-miR-96-5p CSF1 1.14243043653372 0.00942969392739105 -0.306013328429031 0.339617855573793 miRNATAP -0.263546897320587 5.7365562421308e-07 NA NA NA hsa-miR-107 CSF1R 0.904627575346218 4.67936495073904e-05 -1.02341409884128 0.0140396442947017 miRanda -0.545970040887892 3.70105416597969e-05 NA NA NA hsa-miR-339-5p CSF1R 0.770566566962108 0.00816529093411862 -1.02341409884128 0.0140396442947017 miRanda -0.274972569018597 0.00729433056987879 NA NA NA hsa-miR-629-3p CSF1R 1.40326397107309 9.7803063526732e-05 -1.02341409884128 0.0140396442947017 MirTarget -0.231742097251657 0.00448245856132303 NA NA NA hsa-miR-940 CSF3R 1.64406174271686 0.000690854900107004 0.652060868547026 0.176599635952907 MirTarget -0.249751964597886 0.00250861179113934 NA NA NA hsa-miR-30c-2-3p EFNA1 -1.13954984520886 0.000846438233267901 0.996260300178003 0.000133763227919098 MirTarget -0.204058040213358 0.000166758058219795 NA NA NA hsa-miR-491-5p EFNA1 -0.693578126269305 0.0313646742330058 0.996260300178003 0.000133763227919098 miRanda -0.216902768525028 0.000258080701989054 NA NA NA hsa-miR-205-5p EFNA2 3.13520672931882 0.0293226471971167 2.57160457190072 0.0107529034045647 MirTarget -0.388362147927696 3.53243059913237e-17 NA NA NA hsa-miR-30a-5p EFNA3 -1.71922855140016 3.20574349285256e-07 2.02642067098231 2.3674027025848e-05 MirTarget;mirMAP;miRNATAP -0.575401972932312 3.41779536485916e-09 NA NA NA hsa-miR-30c-5p EFNA3 -0.983130268805942 4.60419218706127e-05 2.02642067098231 2.3674027025848e-05 MirTarget;mirMAP;miRNATAP -0.62663735860429 9.40739975448068e-06 NA NA NA hsa-miR-326 EFNA3 -0.429748586406214 0.2629894124021 2.02642067098231 2.3674027025848e-05 MirTarget;miRanda;miRNATAP -0.30939686435267 0.000721990584641849 NA NA NA hsa-miR-361-3p EFNA3 -0.126462931388735 0.566052688733137 2.02642067098231 2.3674027025848e-05 MirTarget;miRNATAP -0.437179664518529 0.00674849886378199 NA NA NA hsa-miR-140-5p EFNA5 0.208193069681326 0.303002433893804 -0.59268728009126 0.197442097474001 miRanda -0.456307446761147 0.00594394639667581 NA NA NA hsa-miR-186-5p EFNA5 0.149964130725901 0.434709542998771 -0.59268728009126 0.197442097474001 mirMAP -0.513291305425438 0.00337437925353359 NA NA NA hsa-miR-19a-3p EFNA5 1.26669687448473 0.000105972838514412 -0.59268728009126 0.197442097474001 miRNATAP -0.314103005278395 0.00144694992199416 NA NA NA hsa-miR-19b-3p EFNA5 0.759818275708988 0.00652779573186786 -0.59268728009126 0.197442097474001 miRNATAP -0.30347780852905 0.0097946885289395 NA NA NA hsa-miR-20a-3p EFNA5 1.13957127410163 0.000451087640268489 -0.59268728009126 0.197442097474001 mirMAP -0.282561710685476 0.00465124532672464 NA NA NA hsa-miR-2110 EFNA5 0.759864042760204 0.0723961390557655 -0.59268728009126 0.197442097474001 mirMAP;miRNATAP -0.239413573709544 0.00218631780518331 NA NA NA hsa-miR-335-3p EFNA5 2.5197689063267 2.20084506976733e-09 -0.59268728009126 0.197442097474001 mirMAP -0.350806591648546 1.54208048603757e-06 NA NA NA hsa-miR-335-5p EFNA5 1.59953351087307 5.56170899867314e-05 -0.59268728009126 0.197442097474001 miRNAWalker2_validate -0.316744466365194 7.88683717662051e-05 NA NA NA hsa-miR-338-3p EFNA5 -0.959276231066179 0.0191473351014091 -0.59268728009126 0.197442097474001 miRanda;miRNATAP -0.320173160906421 4.73048041641712e-05 NA NA NA hsa-miR-361-3p EFNA5 -0.126462931388735 0.566052688733137 -0.59268728009126 0.197442097474001 MirTarget -0.432615662418316 0.00428386030050904 NA NA NA hsa-miR-378a-3p EFNA5 -0.192828831363649 0.530795182107493 -0.59268728009126 0.197442097474001 miRNATAP -0.28783086443859 0.00730497879127635 NA NA NA hsa-miR-421 EFNA5 1.80720854070385 1.59709651202848e-07 -0.59268728009126 0.197442097474001 mirMAP -0.29532170698244 0.00130584115253054 NA NA NA hsa-miR-501-5p EFNA5 0.266919328110625 0.454779001968586 -0.59268728009126 0.197442097474001 mirMAP -0.289855132396456 0.00158892782436729 NA NA NA hsa-miR-577 EFNA5 0.911619788986754 0.2256062124148 -0.59268728009126 0.197442097474001 mirMAP -0.184859339355849 2.48787777636932e-05 NA NA NA hsa-miR-592 EFNA5 0.779567202789068 0.204498177014474 -0.59268728009126 0.197442097474001 mirMAP;miRNATAP -0.186532912805534 0.00104208053334826 NA NA NA hsa-miR-7-1-3p EFNA5 0.709309110750947 0.0412301737463194 -0.59268728009126 0.197442097474001 mirMAP -0.405165408258985 1.27841421738199e-05 NA NA NA hsa-miR-92a-3p EFNA5 1.2209325870225 6.8757197708107e-06 -0.59268728009126 0.197442097474001 miRNAWalker2_validate -0.437246871564517 0.000209421038310427 NA NA NA hsa-miR-107 EGFR 0.904627575346218 4.67936495073904e-05 0.168405729171091 0.73751794453199 miRanda -0.780624524284184 6.54393495762893e-07 NA NA NA hsa-miR-126-5p EGFR 0.41765430251855 0.0753161203651532 0.168405729171091 0.73751794453199 mirMAP -0.430024627428674 0.00524917462605061 NA NA NA hsa-miR-140-5p EGFR 0.208193069681326 0.303002433893804 0.168405729171091 0.73751794453199 miRanda -0.643161622365357 0.00034542548755441 NA NA NA hsa-miR-146a-5p EGFR 1.82051649415508 2.03651725047679e-05 0.168405729171091 0.73751794453199 miRNAWalker2_validate -0.280474680543866 0.000569416646908149 25242818;22161865;25596948;24895573;25417703;23555954;24839931;21632853 Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;MiR 146a suppresses tumor growth and progression by targeting EGFR pathway and in a p ERK dependent manner in castration resistant prostate cancer; Mechanistic studies revealed that miR-146a repressed the expression of EGFR through binding to its 3'-untranslated region; Our findings suggest that ubiquitous loss of miR-146a is a critical mechanism for overexpression of EGFR in CRPC which is crucial to better understanding the pathogenesis of CRPC;Furthermore the expressions of bax and cleaved-caspase-3 mainly were increased in control and overexpression miR-146a groups however the expression of EGFR was inverse; All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells which was performed by up-regulating miR-146a expression then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways and inhibiting invasion through down-regulating the expression of EGFR;Furthermore western blot showed that miR-146a mimic downregulated EGFR ERK1/2 and stat5 signalings; These effects were less potent compared to that of a siRNA targeting EGFR a known target gene of miR-146a; Moreover miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents;Here we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a; We show that BRCA1 binds to MIR146A promoter and activates transcription which in turn attenuates EGFR expression;In functional experiments miR-146a suppressed cell growth induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines H358 H1650 H1975 HCC827 and H292 miR-146a also inhibited the migratory capacity of these NSCLC cells; On the other hand miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR including both TKIs gefitinib erlotinib and afatinib and a monoclonal antibody cetuximab; Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling;Deregulation of miR 146a expression in a mouse model of pancreatic cancer affecting EGFR signaling; Treatment of PC cells with CDF a novel synthetic compound led to re-expression of miR-146a resulting in the down-regulation of EGFR expression; Further knock-down of miR-146a in AsPC-1 cells led to the up-regulation of EGFR expression and showed increased clonogenic growth; In addition knock-down of EGFR by EGFR siRNA transfection of parental AsPC-1 cells and AsPC-1 cells stably transfected with pre-miR-146a resulted in decreased invasive capacity which was further confirmed by reduced luciferase activity in cells transfected with pMIR-Luc reporter vector containing miR-146a binding site; Collectively these results suggest that the loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling and that re-expression of miR-146a by CDF treatment could be useful in designing personalized strategy for the treatment of human PC;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;progression;;;;;; pancreatic cancer;prostate cancer;breast cancer;liver cancer;breast cancer;lung squamous cell cancer;pancreatic cancer;gastric cancer hsa-miR-186-5p EGFR 0.149964130725901 0.434709542998771 0.168405729171091 0.73751794453199 mirMAP -0.543315983386011 0.00447337739548099 NA NA NA hsa-miR-188-5p EGFR 1.35426907033843 0.00038346077691455 0.168405729171091 0.73751794453199 mirMAP -0.351646013165135 0.000124637708877987 NA NA NA hsa-miR-192-3p EGFR 0.355565421687399 0.74117031340037 0.168405729171091 0.73751794453199 mirMAP -0.206727639222232 1.36090223856721e-10 NA NA NA hsa-miR-192-5p EGFR 0.0809146624034405 0.941057093528709 0.168405729171091 0.73751794453199 mirMAP -0.226019181220992 1.67449171990161e-13 NA NA NA hsa-miR-194-3p EGFR 0.259420201261466 0.821811295418686 0.168405729171091 0.73751794453199 MirTarget -0.203898575114252 6.68731990591179e-12 NA NA NA hsa-miR-200a-3p EGFR 0.717826667295984 0.193912116506827 0.168405729171091 0.73751794453199 MirTarget -0.169331211945448 0.00867601958667097 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-29b-2-5p EGFR -1.7015307882027 2.84239251703401e-10 0.168405729171091 0.73751794453199 mirMAP -0.3910017356137 0.00207778215894223 NA NA NA hsa-miR-30d-3p EGFR -0.545113326540761 0.0433733076874155 0.168405729171091 0.73751794453199 mirMAP -0.407148961073724 0.00219111229801308 NA NA NA hsa-miR-320b EGFR 1.11183660885284 0.000497971211648503 0.168405729171091 0.73751794453199 miRanda;mirMAP -0.332140716516881 0.0026979597411761 NA NA NA hsa-miR-335-5p EGFR 1.59953351087307 5.56170899867314e-05 0.168405729171091 0.73751794453199 miRNAWalker2_validate -0.398979814842028 4.4125849451091e-06 NA NA NA hsa-miR-340-5p EGFR -0.164941927483643 0.529910509321278 0.168405729171091 0.73751794453199 mirMAP -0.501426550811941 0.000243508571779912 NA NA NA hsa-miR-362-5p EGFR -0.354508685915981 0.354912078595613 0.168405729171091 0.73751794453199 mirMAP -0.432765239197852 2.36063976575942e-06 NA NA NA hsa-miR-375 EGFR -2.94506033785642 0.00570147601654791 0.168405729171091 0.73751794453199 miRanda -0.189586479112383 2.94006132397572e-09 NA NA NA hsa-miR-378c EGFR -1.27752074861415 2.73676010235611e-05 0.168405729171091 0.73751794453199 mirMAP -0.494126324357503 1.44640511557456e-05 NA NA NA hsa-miR-501-5p EGFR 0.266919328110625 0.454779001968586 0.168405729171091 0.73751794453199 mirMAP -0.499445439422852 3.55760656495929e-07 NA NA NA hsa-miR-577 EGFR 0.911619788986754 0.2256062124148 0.168405729171091 0.73751794453199 mirMAP -0.181043665182683 0.000164650893742774 NA NA NA hsa-miR-7-1-3p EGFR 0.709309110750947 0.0412301737463194 0.168405729171091 0.73751794453199 mirMAP -0.453112022139855 7.47168008914619e-06 NA NA NA hsa-miR-7-5p EGFR 1.63575693499363 0.0124424214624534 0.168405729171091 0.73751794453199 miRNAWalker2_validate;miRTarBase;MirTarget -0.267933940433673 1.42488777071465e-06 26708917;23115635;25503932;21712475;25334070;25532106;27203220;25862909;24816687;20978205;24603851;24573489;25289099;23227519 In addition the experimental data also suggest that miR-7 can interfere with EGFR mRNA translation; In addition miR-7 may function by interfering with EGFR mRNA translation but not degradation;Several studies have demonstrated that microRNA-7 miR-7 regulates EGFR expression and Akt activity in a range of cancer cell types via its specific interaction with the EGFR mRNA 3'-untranslated region 3'-UTR; Together these data support the coordinate regulation of Akt signaling by miR-7 in HNC cells and suggest the therapeutic potential of miR-7 alone or in combination with EGFR TKIs in this disease;The potential for miR-7 to act as a tumor suppressor by coordinately regulating the epidermal growth factor receptor EGFR signaling pathway at several levels was examined; We investigated the tumor inhibitory effect of miR-7 in CRC with particular focus on the relationship between miR-7 and the EGFR pathway; The regulation of EGFR by miR-7 was examined with miR-7 precursor-transfected cells; Furthermore we investigated whether miR-7 suppresses proliferation of CRC cells in combination with cetuximab a monoclonal antibody against EGFR; In vitro assays showed that EGFR and RAF-1 are direct targets of miR-7 which potently suppressed the proliferation of CRC cells and interestingly that the growth inhibitory effect of each of these was enhanced by cetuximab;To overcome the resistance we focused on EGFR suppression using microRNA-7 miR-7 targeting multiple sites in the 3'-untranslated region of EGFR mRNA;Furthermore inhibition of EGFR showed similar effects to miR-7 enforcement in 3LL cells; Taken together these findings revealed that miR-7 acts as an antitumor miRNA in 3LL by targeting and suppressing the expression of both EGFR and RAF-1 oncogenes;MiR-7 inhibited MCF-7/HER2Δ16 cell migration through a mechanism involving suppression of the miR-7 target gene EGFR; In contrast miR-7 inhibition of MCF-7/HER2Δ16 cell proliferation involved a pathway where miR-7 expression resulted in the inactivation of Src kinase independent of suppressed EGFR expression; Also independent of EGFR suppression reestablished miR-7 expression sensitized refractory MCF-7/HER2Δ16 cells to trastuzumab; We propose that miR-7 regulated pathways including EGFR and Src kinase represent targets for the therapeutic intervention of refractory and metastatic HER2Δ16 driven breast cancer;microRNA-7-5p miR-7-5p is a tumor suppressor in multiple cancer types and inhibits growth and invasion by suppressing expression and activity of the epidermal growth factor receptor EGFR signaling pathway;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;In recent years mounting evidence indicates that EGFR is a direct and functional target of miR-7; In this study we found that miR-7 expression was significantly downregulated in highly metastatic epithelial ovarian cancer EOC cell lines and metastatic tissues whereas the expression of EGFR correlated positively with metastasis in both EOC patients and cell lines; Finally the expression of miR-7 and EGFR in primary EOC with matched metastasis tissues was explored; It was showed that miR-7 is inversely correlated with EGFR; Taken together our results suggested that miR-7 inhibited tumor metastasis and reversed EMT through AKT and ERK1/2 pathway inactivation by reducing EGFR expression in EOC cell lines;In this study we report the discovery and mechanistic characterization of the miRNA miR-7 as an oncogenic "oncomiR" and its role as a key mediator of EGFR signaling in lung cancer cells;We show that microRNA-7 miR-7 is a common regulator of the phosphoinositide-3-kinase PI3K/ATK and Raf/mitogen-activated protein kinase kinase MEK/extracellular signal-regulated kinase ERK pathways both of which are launched by EGFR through its two direct targets the transcription factors PI3K and Raf-1 respectively; We conclude that miR-7 is a potential tumor suppressor in glioblastoma that acts by targeting multiple oncogenes related to the downstream pathway of EGFR and may serve as a novel therapeutic target for malignant gliomas;Further study will investigate miR-7 in the regulation of EGFR expression in vitro and in vivo;Pretreatment of miR-7 mimics enhanced the PTX-mediated downregulation of epidermal growth factor receptor EGFR in NSCLC cells;We identified miR-7 as the important miRNA associated with estrogen actions in these cells and further examined the changes of estrogen-dependent EGFR expression by miR-7 in ER-positive or -negative breast carcinoma cell lines including MCF-7; We also evaluated the correlation between miR-7 and EGFR expression in breast carcinoma cells derived from 21 patients using laser capture microdissection combined with quantitative reverse transcriptase-PCR; miR-7 was reported to suppress epidermal growth factor receptor EGFR expression in several human malignancies; Transfection of miR-7 significantly suppressed EGFR mRNA levels in MCF-7 cells; We also evaluated the status of miR-7 in breast carcinoma tissues but the correlation between the status of miR-7 and EGFR in carcinoma cells isolated by laser capture microscopy was not detected; These results suggest that miR-7 may play a role in the development of resistance to endocrine therapy in breast cancer patients through regulating EGFR expression of carcinoma cells ;;;drug resistance;;cell migration;;;metastasis;;malignant trasformation;;;drug resistance esophageal cancer;head and neck cancer;colorectal cancer;lung cancer;lung cancer;breast cancer;melanoma;ovarian cancer;ovarian cancer;lung cancer;glioblastoma;gastric cancer;lung squamous cell cancer;breast cancer hsa-miR-877-5p EGFR 2.17859965442336 1.03593450648516e-07 0.168405729171091 0.73751794453199 mirMAP -0.228987457354068 0.00665763782285166 NA NA NA hsa-miR-125a-5p EIF4E2 -0.878090699011564 0.000213630844319685 -0.0270523638767566 0.82668940326952 miRanda -0.151104346013907 2.45983234711003e-05 NA NA NA hsa-miR-125a-5p EIF4EBP1 -0.878090699011564 0.000213630844319685 1.10048942322699 0.000734215888573154 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.414005533193724 2.17946619226446e-05 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ovarian cancer hsa-miR-125a-5p EPHA2 -0.878090699011564 0.000213630844319685 1.1792195104295 0.00132403133641615 miRanda -0.306021671901184 0.00595912459051825 NA NA NA hsa-miR-326 EPO -0.429748586406214 0.2629894124021 0.927575834727 0.193658270560895 miRanda -0.493138948696525 0.000212141785251677 NA NA NA hsa-miR-338-3p EPO -0.959276231066179 0.0191473351014091 0.927575834727 0.193658270560895 miRanda -0.648685939232671 6.94489897307612e-08 NA NA NA hsa-miR-362-3p EPO -0.0349414695893027 0.913780708043777 0.927575834727 0.193658270560895 miRanda -0.592181368877243 0.000174734758673846 NA NA NA hsa-miR-23b-3p F2R -0.286465516491361 0.18664668472995 1.19411285857973 0.000493826437676024 MirTarget -0.434878858642516 0.000157016357605448 NA NA NA hsa-miR-92b-3p FASLG 1.33518446513417 1.45350885391576e-06 0.493896235569131 0.390001245956277 miRNATAP -0.542744180708012 0.000155394781632395 NA NA NA hsa-miR-126-5p FGF1 0.41765430251855 0.0753161203651532 -0.160234396361762 0.733972871379557 mirMAP -0.59094523029959 3.50264864833946e-05 NA NA NA hsa-miR-16-1-3p FGF1 1.43227522002564 3.70920454953168e-08 -0.160234396361762 0.733972871379557 mirMAP -0.415017127195873 0.000891606226757529 NA NA NA hsa-miR-186-5p FGF1 0.149964130725901 0.434709542998771 -0.160234396361762 0.733972871379557 mirMAP -0.802927092384163 5.33712623622096e-06 NA NA NA hsa-miR-18a-5p FGF1 2.20211504140984 1.78678887916334e-09 -0.160234396361762 0.733972871379557 MirTarget -0.427564859159038 6.45322365688328e-07 NA NA NA hsa-miR-222-5p FGF1 1.87968474330782 1.11743009485711e-06 -0.160234396361762 0.733972871379557 MirTarget -0.328069555060374 8.83297301332189e-05 NA NA NA hsa-miR-26b-3p FGF1 -0.0103961389461977 0.965770899625511 -0.160234396361762 0.733972871379557 MirTarget -0.614591765464955 8.91145535430066e-06 NA NA NA hsa-miR-29a-5p FGF1 0.585084040404152 0.023014129158495 -0.160234396361762 0.733972871379557 mirMAP -0.604881337368894 2.58167935202965e-06 NA NA NA hsa-miR-320a FGF1 0.593888711838028 0.011897419390526 -0.160234396361762 0.733972871379557 miRanda -0.386072945122806 0.00701900096114403 NA NA NA hsa-miR-320b FGF1 1.11183660885284 0.000497971211648503 -0.160234396361762 0.733972871379557 miRanda -0.368173004233106 0.000368398615653149 NA NA NA hsa-miR-326 FGF1 -0.429748586406214 0.2629894124021 -0.160234396361762 0.733972871379557 miRanda;miRNATAP -0.385294600510288 9.62075997895276e-06 NA NA NA hsa-miR-330-5p FGF1 0.488365986827708 0.0512207630808233 -0.160234396361762 0.733972871379557 miRanda;miRNATAP -0.490680892266321 0.000251789498451697 NA NA NA hsa-miR-429 FGF1 1.40182602301928 0.00900426780286475 -0.160234396361762 0.733972871379557 miRNATAP -0.323262102446773 7.92592247701929e-08 NA NA NA hsa-miR-484 FGF1 0.71327898984355 0.00233605130771196 -0.160234396361762 0.733972871379557 MirTarget;PITA;miRNATAP -0.408471643921956 0.00445789085377771 NA NA NA hsa-miR-532-3p FGF1 0.552364451472481 0.0975490365586023 -0.160234396361762 0.733972871379557 miRNATAP -0.744864947914853 2.30927245315596e-15 NA NA NA hsa-miR-550a-5p FGF1 2.27360629906903 2.14504977831873e-07 -0.160234396361762 0.733972871379557 MirTarget -0.412011719251591 1.06463288268876e-08 NA NA NA hsa-miR-590-5p FGF1 1.04171442093217 0.000272475544954865 -0.160234396361762 0.733972871379557 MirTarget;miRanda;miRNATAP -0.411316166846436 0.00036918107931291 NA NA NA hsa-miR-625-5p FGF1 0.537211086526376 0.203801009380384 -0.160234396361762 0.733972871379557 MirTarget -0.597908728237488 7.37909450819918e-16 NA NA NA hsa-miR-629-5p FGF1 1.06377074768516 0.000536624707722274 -0.160234396361762 0.733972871379557 MirTarget -0.349957209459157 0.00121021361741485 NA NA NA hsa-miR-7-5p FGF1 1.63575693499363 0.0124424214624534 -0.160234396361762 0.733972871379557 miRNAWalker2_validate -0.334571255736156 4.63756500683767e-11 NA NA NA hsa-let-7f-5p FGF11 0.634633924115866 0.0344982923411787 1.34606246397032 0.0313874796480627 mirMAP;miRNATAP -0.594039289750789 5.85711011149972e-05 NA NA NA hsa-let-7g-5p FGF11 0.325297685027927 0.241142963826631 1.34606246397032 0.0313874796480627 mirMAP;miRNATAP -0.875110015083308 3.01548567374744e-08 NA NA NA hsa-miR-10a-5p FGF11 -0.470861534765518 0.148803248989189 1.34606246397032 0.0313874796480627 mirMAP -0.839577254558606 2.06461410522248e-10 NA NA NA hsa-miR-217 FGF11 -0.0121404731225336 0.980818372851502 1.34606246397032 0.0313874796480627 PITA;miRanda -0.251553843688479 0.00449992982096522 NA NA NA hsa-miR-326 FGF11 -0.429748586406214 0.2629894124021 1.34606246397032 0.0313874796480627 MirTarget;PITA;miRanda;miRNATAP -0.444845744428783 0.000143421345045733 NA NA NA hsa-miR-335-5p FGF11 1.59953351087307 5.56170899867314e-05 1.34606246397032 0.0313874796480627 miRNAWalker2_validate;mirMAP -0.384291765399063 0.000482054927218443 NA NA NA hsa-miR-532-3p FGF11 0.552364451472481 0.0975490365586023 1.34606246397032 0.0313874796480627 mirMAP -0.60511003013694 4.75511871948254e-06 NA NA NA hsa-let-7f-1-3p FGF12 1.28704406797397 1.17954701106157e-06 -0.587357499262027 0.310516155638288 MirTarget -0.500961231356776 0.000998540142849314 NA NA NA hsa-miR-29a-5p FGF12 0.585084040404152 0.023014129158495 -0.587357499262027 0.310516155638288 MirTarget -0.561752160653773 0.000457570295243942 NA NA NA hsa-let-7f-1-3p FGF13 1.28704406797397 1.17954701106157e-06 -2.34574028365922 0.000183807352189951 MirTarget -0.563169375210783 0.000773915454703851 NA NA NA hsa-miR-141-3p FGF13 1.45548825076434 0.00115958850961764 -2.34574028365922 0.000183807352189951 TargetScan -0.419319186157982 2.18410603313764e-05 NA NA NA hsa-miR-200a-5p FGF13 1.50371809098978 0.00263602434344863 -2.34574028365922 0.000183807352189951 MirTarget;miRNATAP -0.316435602783381 0.000388466610194628 NA NA NA hsa-miR-200b-5p FGF13 0.969871521250413 0.0530500454130183 -2.34574028365922 0.000183807352189951 MirTarget -0.346419909837961 0.000222834092725641 NA NA NA hsa-miR-31-3p FGF13 0.474904754927656 0.506866261575484 -2.34574028365922 0.000183807352189951 miRNATAP -0.216224775700072 0.000656063150041637 NA NA NA hsa-miR-3682-3p FGF13 1.96838261925327 4.94885331227292e-06 -2.34574028365922 0.000183807352189951 MirTarget -0.406979633607707 0.000829055016383721 NA NA NA hsa-miR-429 FGF13 1.40182602301928 0.00900426780286475 -2.34574028365922 0.000183807352189951 miRNATAP -0.296325455439465 0.000372916450321645 NA NA NA hsa-miR-455-5p FGF13 1.20462751989145 6.74386011867484e-05 -2.34574028365922 0.000183807352189951 PITA;miRanda -0.492592516788581 0.000853952308418692 NA NA NA hsa-miR-590-3p FGF13 1.11654983899947 0.000160782154924864 -2.34574028365922 0.000183807352189951 miRanda -0.496872134281738 0.00103030244047749 NA NA NA hsa-miR-7-1-3p FGF13 0.709309110750947 0.0412301737463194 -2.34574028365922 0.000183807352189951 MirTarget;mirMAP -0.473759888075165 0.000258502260079092 NA NA NA hsa-miR-421 FGF14 1.80720854070385 1.59709651202848e-07 -2.26824495321978 0.000644201162802339 miRanda -0.51290819363414 0.000127157329894553 NA NA NA hsa-miR-590-3p FGF14 1.11654983899947 0.000160782154924864 -2.26824495321978 0.000644201162802339 miRanda -0.775153716412423 8.24216834793137e-07 NA NA NA hsa-miR-96-5p FGF14 1.14243043653372 0.00942969392739105 -2.26824495321978 0.000644201162802339 TargetScan -0.326435839133923 0.00402772700697129 NA NA NA hsa-miR-16-5p FGF18 1.00515772948091 5.33912942007619e-06 -0.701320708357095 0.262070500539484 miRNATAP -0.544910968247721 0.00650462011718626 NA NA NA hsa-miR-424-5p FGF18 1.08509868581983 0.000420473853818268 -0.701320708357095 0.262070500539484 miRNATAP -0.446614957034455 0.0018153474746596 NA NA NA hsa-miR-590-5p FGF18 1.04171442093217 0.000272475544954865 -0.701320708357095 0.262070500539484 miRanda;miRNATAP -0.766369227739518 3.8382097156196e-07 NA NA NA hsa-miR-9-5p FGF18 -0.195328736653048 0.761470692992178 -0.701320708357095 0.262070500539484 miRNATAP -0.237173048014931 0.000555869006551748 NA NA NA hsa-let-7a-3p FGF2 0.503048155002889 0.0411145454335299 -1.87861117290298 0.000125445679104344 mirMAP -0.410539117311516 0.00473622063740347 NA NA NA hsa-let-7b-3p FGF2 0.21838629112113 0.296038413622566 -1.87861117290298 0.000125445679104344 mirMAP -0.469514467711896 0.00680853109557966 NA NA NA hsa-let-7f-1-3p FGF2 1.28704406797397 1.17954701106157e-06 -1.87861117290298 0.000125445679104344 mirMAP -0.595048658334427 4.14210020217409e-06 NA NA NA hsa-miR-103a-3p FGF2 0.840525139266028 5.83536475789158e-07 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate;MirTarget;miRNATAP -0.939824662070765 6.5144907085955e-06 NA NA NA hsa-miR-107 FGF2 0.904627575346218 4.67936495073904e-05 -1.87861117290298 0.000125445679104344 MirTarget;PITA;miRanda;miRNATAP -0.633691610533513 5.77496353910729e-05 NA NA NA hsa-miR-15a-5p FGF2 1.03783090449383 7.40334108980898e-07 -1.87861117290298 0.000125445679104344 MirTarget;miRNATAP -0.723624902429406 1.17476403328068e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 1.75738933306437 3.00554466232543e-08 -1.87861117290298 0.000125445679104344 mirMAP -0.601578664515957 9.71241978321172e-09 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 1.62046407540723 5.42152621571078e-09 -1.87861117290298 0.000125445679104344 MirTarget;miRNATAP -0.727556694335382 9.63850854162267e-10 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 1.43227522002564 3.70920454953168e-08 -1.87861117290298 0.000125445679104344 mirMAP -0.533569195692814 4.82742810832383e-05 NA NA NA hsa-miR-16-2-3p FGF2 1.8048179609245 2.83095715136409e-09 -1.87861117290298 0.000125445679104344 mirMAP -0.582691850054445 1.0626071080659e-07 NA NA NA hsa-miR-16-5p FGF2 1.00515772948091 5.33912942007619e-06 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate;MirTarget;miRNATAP -0.87728356493459 1.36815119437221e-08 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-186-5p FGF2 0.149964130725901 0.434709542998771 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate;mirMAP -0.536525732490695 0.00470973709226905 NA NA NA hsa-miR-192-5p FGF2 0.0809146624034405 0.941057093528709 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate -0.100431705795905 0.00182203175890127 NA NA NA hsa-miR-19b-1-5p FGF2 1.38738648038895 1.3113681938066e-06 -1.87861117290298 0.000125445679104344 mirMAP -0.540056441979374 5.90790389026898e-06 NA NA NA hsa-miR-200b-3p FGF2 0.974577911407732 0.0595020056914543 -1.87861117290298 0.000125445679104344 mirMAP -0.35358155461024 1.0502797949384e-07 NA NA NA hsa-miR-200c-3p FGF2 1.28185685499076 0.00369777635539177 -1.87861117290298 0.000125445679104344 mirMAP -0.459255722541169 2.21550497680624e-09 NA NA NA hsa-miR-20a-3p FGF2 1.13957127410163 0.000451087640268489 -1.87861117290298 0.000125445679104344 mirMAP -0.635980126804227 1.03782626210616e-09 NA NA NA hsa-miR-21-3p FGF2 1.75245546017565 2.36505176715025e-10 -1.87861117290298 0.000125445679104344 mirMAP -0.541952936598777 7.7895313994942e-06 NA NA NA hsa-miR-21-5p FGF2 1.75445050487988 2.41825549682022e-23 -1.87861117290298 0.000125445679104344 mirMAP -0.484524479326667 0.00821705219155879 NA NA NA hsa-miR-215-5p FGF2 0.715250240418615 0.573784317311889 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate -0.104771518281948 0.000141751804794456 NA NA NA hsa-miR-221-3p FGF2 1.33496247538338 3.82022531235275e-07 -1.87861117290298 0.000125445679104344 mirMAP -0.544428779797939 3.02629502512127e-05 NA NA NA hsa-miR-222-3p FGF2 1.39382731585819 9.98182478024671e-07 -1.87861117290298 0.000125445679104344 mirMAP -0.541204112402845 6.44319127167856e-06 NA NA NA hsa-miR-29a-5p FGF2 0.585084040404152 0.023014129158495 -1.87861117290298 0.000125445679104344 mirMAP -0.424035558508381 0.00219032018724374 NA NA NA hsa-miR-330-3p FGF2 0.798460296022179 0.00746538156533435 -1.87861117290298 0.000125445679104344 mirMAP -0.498128953238189 2.14033471411407e-05 NA NA NA hsa-miR-335-3p FGF2 2.5197689063267 2.20084506976733e-09 -1.87861117290298 0.000125445679104344 mirMAP -0.417269866841731 1.09046144483422e-07 NA NA NA hsa-miR-335-5p FGF2 1.59953351087307 5.56170899867314e-05 -1.87861117290298 0.000125445679104344 miRNATAP -0.323054850441658 0.000208841445593432 NA NA NA hsa-miR-3662 FGF2 1.82780708047676 0.0054036501346178 -1.87861117290298 0.000125445679104344 mirMAP -0.212606715986015 0.00207695589115596 NA NA NA hsa-miR-3682-3p FGF2 1.96838261925327 4.94885331227292e-06 -1.87861117290298 0.000125445679104344 mirMAP -0.621299624827262 8.40451860827003e-12 NA NA NA hsa-miR-424-5p FGF2 1.08509868581983 0.000420473853818268 -1.87861117290298 0.000125445679104344 MirTarget;miRNATAP -0.473116310929624 2.79114365346124e-05 NA NA NA hsa-miR-429 FGF2 1.40182602301928 0.00900426780286475 -1.87861117290298 0.000125445679104344 mirMAP -0.389653476745427 6.14878920514716e-10 NA NA NA hsa-miR-503-5p FGF2 1.88558728489534 2.26317868368257e-06 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate -0.328905971783003 0.000129296346907329 NA NA NA hsa-miR-577 FGF2 0.911619788986754 0.2256062124148 -1.87861117290298 0.000125445679104344 mirMAP -0.189066289658318 7.18727306857422e-05 NA NA NA hsa-miR-589-3p FGF2 1.01962606923682 0.00577853347252709 -1.87861117290298 0.000125445679104344 mirMAP -0.306084948128741 0.00129523811230291 NA NA NA hsa-miR-590-3p FGF2 1.11654983899947 0.000160782154924864 -1.87861117290298 0.000125445679104344 miRanda;mirMAP -0.502156114781839 1.81367444334514e-05 NA NA NA hsa-miR-590-5p FGF2 1.04171442093217 0.000272475544954865 -1.87861117290298 0.000125445679104344 miRanda;mirMAP -0.698076507895779 4.36148419548274e-09 NA NA NA hsa-miR-92a-3p FGF2 1.2209325870225 6.8757197708107e-06 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate -0.711959382156384 1.14570619492506e-08 NA NA NA hsa-miR-93-3p FGF2 1.88964231421793 1.80075645722786e-08 -1.87861117290298 0.000125445679104344 mirMAP -0.494286067593777 7.56548629194091e-07 NA NA NA hsa-miR-126-5p FGF5 0.41765430251855 0.0753161203651532 -0.112737413770707 0.889018159422693 mirMAP -1.27299674044633 1.36904003609118e-07 NA NA NA hsa-miR-15b-5p FGF5 1.62046407540723 5.42152621571078e-09 -0.112737413770707 0.889018159422693 miRNAWalker2_validate -0.628499833905292 0.00163763954361993 NA NA NA hsa-miR-16-1-3p FGF5 1.43227522002564 3.70920454953168e-08 -0.112737413770707 0.889018159422693 mirMAP -0.598397522653231 0.00540255809360042 NA NA NA hsa-miR-30b-5p FGF5 -0.430720743745757 0.0593564057320791 -0.112737413770707 0.889018159422693 mirMAP -1.09663962120345 1.27869374681852e-05 NA NA NA hsa-miR-30d-5p FGF5 -0.5492586056147 0.0140125082460125 -0.112737413770707 0.889018159422693 mirMAP -1.26603557046881 6.44034616744386e-07 NA NA NA hsa-miR-32-3p FGF5 0.583525764322974 0.11837203008551 -0.112737413770707 0.889018159422693 mirMAP -0.718233961496998 2.69211257467585e-05 NA NA NA hsa-miR-335-3p FGF5 2.5197689063267 2.20084506976733e-09 -0.112737413770707 0.889018159422693 mirMAP -0.482052236534025 0.00020013696125674 NA NA NA hsa-miR-338-3p FGF5 -0.959276231066179 0.0191473351014091 -0.112737413770707 0.889018159422693 miRanda -0.6177985816089 6.96794360953983e-06 NA NA NA hsa-miR-33a-3p FGF5 0.347011402017138 0.321709379745392 -0.112737413770707 0.889018159422693 mirMAP -0.576535909647833 0.000837306247871141 NA NA NA hsa-miR-500a-5p FGF5 0.00337014556047865 0.992120109131868 -0.112737413770707 0.889018159422693 mirMAP -0.614477528187278 0.000256513680663112 NA NA NA hsa-miR-501-5p FGF5 0.266919328110625 0.454779001968586 -0.112737413770707 0.889018159422693 PITA;mirMAP -0.62614984876482 9.06674208094652e-05 NA NA NA hsa-miR-577 FGF5 0.911619788986754 0.2256062124148 -0.112737413770707 0.889018159422693 miRNATAP -0.444405147807268 3.59000876753453e-09 NA NA NA hsa-miR-590-3p FGF5 1.11654983899947 0.000160782154924864 -0.112737413770707 0.889018159422693 miRanda;mirMAP;miRNATAP -0.612555222447379 0.00140100895653425 NA NA NA hsa-miR-7-1-3p FGF5 0.709309110750947 0.0412301737463194 -0.112737413770707 0.889018159422693 mirMAP -0.869207993564472 6.50749322750585e-08 NA NA NA hsa-let-7a-3p FGF7 0.503048155002889 0.0411145454335299 -1.5602156825587 0.00498637377963977 MirTarget;miRNATAP -0.731037360749972 5.50569814204452e-06 NA NA NA hsa-let-7b-3p FGF7 0.21838629112113 0.296038413622566 -1.5602156825587 0.00498637377963977 MirTarget;miRNATAP -0.741810215119105 0.000124390628283528 NA NA NA hsa-let-7f-1-3p FGF7 1.28704406797397 1.17954701106157e-06 -1.5602156825587 0.00498637377963977 MirTarget -0.619496528449976 2.19591491777331e-05 NA NA NA hsa-miR-107 FGF7 0.904627575346218 4.67936495073904e-05 -1.5602156825587 0.00498637377963977 PITA;miRanda;miRNATAP -0.777246028518609 1.06521367448641e-05 NA NA NA hsa-miR-15a-5p FGF7 1.03783090449383 7.40334108980898e-07 -1.5602156825587 0.00498637377963977 miRTarBase;miRNATAP -1.03381303077926 1.53980295049369e-08 NA NA NA hsa-miR-15b-5p FGF7 1.62046407540723 5.42152621571078e-09 -1.5602156825587 0.00498637377963977 miRNATAP -1.10853915197794 3.91159333945632e-18 NA NA NA hsa-miR-16-1-3p FGF7 1.43227522002564 3.70920454953168e-08 -1.5602156825587 0.00498637377963977 mirMAP -0.828766285961256 1.00941095464602e-08 NA NA NA hsa-miR-16-2-3p FGF7 1.8048179609245 2.83095715136409e-09 -1.5602156825587 0.00498637377963977 mirMAP -0.894500676245952 5.67629159494697e-14 NA NA NA hsa-miR-16-5p FGF7 1.00515772948091 5.33912942007619e-06 -1.5602156825587 0.00498637377963977 miRNATAP -1.4084082340258 1.61565851852723e-17 NA NA NA hsa-miR-18a-3p FGF7 2.35188582849667 1.39401350286321e-08 -1.5602156825587 0.00498637377963977 MirTarget -0.60538245987518 7.27850574065591e-12 NA NA NA hsa-miR-20a-5p FGF7 1.4503375861709 5.7813456424762e-07 -1.5602156825587 0.00498637377963977 miRNAWalker2_validate -0.815425734145646 2.61657869983007e-10 NA NA NA hsa-miR-26b-5p FGF7 -0.301646326928219 0.160081421968103 -1.5602156825587 0.00498637377963977 mirMAP -0.573628684843975 0.0024027834337405 NA NA NA hsa-miR-27a-3p FGF7 1.29886998470345 2.68986118553486e-08 -1.5602156825587 0.00498637377963977 MirTarget -0.784712509256695 1.6375276114047e-06 NA NA NA hsa-miR-31-5p FGF7 0.666358292391859 0.381800494600846 -1.5602156825587 0.00498637377963977 MirTarget -0.286141542958258 9.31592868791215e-08 NA NA NA hsa-miR-320a FGF7 0.593888711838028 0.011897419390526 -1.5602156825587 0.00498637377963977 miRanda -0.501509634690982 0.00321500749912934 NA NA NA hsa-miR-320b FGF7 1.11183660885284 0.000497971211648503 -1.5602156825587 0.00498637377963977 miRanda -0.602963126908309 6.53118857584566e-07 NA NA NA hsa-miR-33a-3p FGF7 0.347011402017138 0.321709379745392 -1.5602156825587 0.00498637377963977 mirMAP -0.714323468107036 6.96759113987999e-10 NA NA NA hsa-miR-361-5p FGF7 0.407725414130987 0.0181260969156347 -1.5602156825587 0.00498637377963977 PITA;miRanda;miRNATAP -1.05023708199515 7.33408072452573e-06 NA NA NA hsa-miR-3662 FGF7 1.82780708047676 0.0054036501346178 -1.5602156825587 0.00498637377963977 MirTarget;mirMAP;miRNATAP -0.343246402685412 7.47671778480477e-06 NA NA NA hsa-miR-421 FGF7 1.80720854070385 1.59709651202848e-07 -1.5602156825587 0.00498637377963977 miRanda -0.472997333251649 1.97004361691138e-05 NA NA NA hsa-miR-424-5p FGF7 1.08509868581983 0.000420473853818268 -1.5602156825587 0.00498637377963977 miRNATAP -0.685297094218223 4.20996402527186e-08 NA NA NA hsa-miR-429 FGF7 1.40182602301928 0.00900426780286475 -1.5602156825587 0.00498637377963977 miRNATAP -0.402624994165276 1.7337446619432e-08 NA NA NA hsa-miR-452-5p FGF7 2.08756506185889 0.000258095769002813 -1.5602156825587 0.00498637377963977 mirMAP -0.269324797275113 7.28201796410245e-05 NA NA NA hsa-miR-455-3p FGF7 2.29532323519288 1.85675588946527e-07 -1.5602156825587 0.00498637377963977 PITA;miRNATAP -0.699538843370974 3.81324365803807e-18 NA NA NA hsa-miR-484 FGF7 0.71327898984355 0.00233605130771196 -1.5602156825587 0.00498637377963977 PITA -0.917837472299362 3.34732094641496e-08 NA NA NA hsa-miR-486-5p FGF7 -0.627607241830911 0.155274583521138 -1.5602156825587 0.00498637377963977 MirTarget;miRanda -0.269041213010616 0.00282702512889706 NA NA NA hsa-miR-542-3p FGF7 0.757649022262991 0.00210575463285599 -1.5602156825587 0.00498637377963977 miRanda -0.575428372905158 0.000361082468087173 NA NA NA hsa-miR-577 FGF7 0.911619788986754 0.2256062124148 -1.5602156825587 0.00498637377963977 PITA;mirMAP -0.260587392511629 8.78612250385762e-07 NA NA NA hsa-miR-582-3p FGF7 -0.412897415951272 0.202939245403793 -1.5602156825587 0.00498637377963977 PITA;miRNATAP -0.478173140136422 9.36091921722173e-05 NA NA NA hsa-miR-590-3p FGF7 1.11654983899947 0.000160782154924864 -1.5602156825587 0.00498637377963977 PITA;miRanda;mirMAP;miRNATAP -0.672431604720525 2.51151561650779e-07 NA NA NA hsa-miR-590-5p FGF7 1.04171442093217 0.000272475544954865 -1.5602156825587 0.00498637377963977 PITA;miRanda -0.997192552428985 1.50828670699697e-14 NA NA NA hsa-miR-616-5p FGF7 0.834052908652744 0.0347835664029363 -1.5602156825587 0.00498637377963977 mirMAP -0.499565899304345 6.56838525058638e-07 NA NA NA hsa-miR-7-1-3p FGF7 0.709309110750947 0.0412301737463194 -1.5602156825587 0.00498637377963977 mirMAP -0.445680137233784 8.82810683468222e-05 NA NA NA hsa-miR-944 FGF7 3.33123095809751 0.0177835044930391 -1.5602156825587 0.00498637377963977 mirMAP -0.136791859053773 3.4948596692363e-05 NA NA NA hsa-miR-16-2-3p FGF9 1.8048179609245 2.83095715136409e-09 -1.74987286650449 0.0113341158170243 mirMAP -0.451752198937279 0.00402672168929665 NA NA NA hsa-miR-205-5p FGF9 3.13520672931882 0.0293226471971167 -1.74987286650449 0.0113341158170243 miRNATAP -0.152174402639521 6.027271820105e-06 NA NA NA hsa-miR-369-3p FGF9 0.32261175629684 0.3589927609891 -1.74987286650449 0.0113341158170243 mirMAP;miRNATAP -0.386601318549715 0.00627732180260434 NA NA NA hsa-miR-455-5p FGF9 1.20462751989145 6.74386011867484e-05 -1.74987286650449 0.0113341158170243 miRanda -0.615588799082101 0.000125067222771029 NA NA NA hsa-miR-944 FGF9 3.33123095809751 0.0177835044930391 -1.74987286650449 0.0113341158170243 mirMAP -0.169847944100435 3.49963470746257e-05 NA NA NA hsa-miR-106b-5p FGFR1 1.70863907461894 2.04074794107142e-08 -1.49877035356464 0.000511032592490219 mirMAP -0.289574146617841 0.00338081665085451 NA NA NA hsa-miR-135b-5p FGFR1 4.09156383496059 1.32294295002438e-12 -1.49877035356464 0.000511032592490219 mirMAP -0.239971522992425 1.30604624157818e-06 NA NA NA hsa-miR-15a-5p FGFR1 1.03783090449383 7.40334108980898e-07 -1.49877035356464 0.000511032592490219 miRNATAP -0.614121259747611 2.31269640677994e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGFR1 1.62046407540723 5.42152621571078e-09 -1.49877035356464 0.000511032592490219 miRNATAP -0.428887511985041 6.35940222533532e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 1.00515772948091 5.33912942007619e-06 -1.49877035356464 0.000511032592490219 miRTarBase;miRNATAP -0.646816679192102 2.46444393209917e-06 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 1.65862087862483 8.45603406215941e-08 -1.49877035356464 0.000511032592490219 mirMAP -0.385666132191953 6.54751310730238e-05 NA NA NA hsa-miR-200a-5p FGFR1 1.50371809098978 0.00263602434344863 -1.49877035356464 0.000511032592490219 mirMAP -0.353457026193588 2.65731844551453e-09 NA NA NA hsa-miR-200b-5p FGFR1 0.969871521250413 0.0530500454130183 -1.49877035356464 0.000511032592490219 mirMAP -0.379845880120484 1.1792923473536e-09 NA NA NA hsa-miR-20a-5p FGFR1 1.4503375861709 5.7813456424762e-07 -1.49877035356464 0.000511032592490219 mirMAP -0.375915424325503 0.00030587275135307 NA NA NA hsa-miR-330-3p FGFR1 0.798460296022179 0.00746538156533435 -1.49877035356464 0.000511032592490219 PITA;miRNATAP -0.282998543312954 0.00663632549076157 NA NA NA hsa-miR-330-5p FGFR1 0.488365986827708 0.0512207630808233 -1.49877035356464 0.000511032592490219 miRanda;miRNATAP -0.46885020733595 0.000163163733168213 NA NA NA hsa-miR-335-3p FGFR1 2.5197689063267 2.20084506976733e-09 -1.49877035356464 0.000511032592490219 mirMAP -0.292645618532702 2.80734523112232e-05 NA NA NA hsa-miR-532-5p FGFR1 0.313080805824184 0.252248939356301 -1.49877035356464 0.000511032592490219 PITA -0.412833293773713 0.000296657475622566 NA NA NA hsa-miR-577 FGFR1 0.911619788986754 0.2256062124148 -1.49877035356464 0.000511032592490219 PITA;mirMAP -0.163290896258138 9.38787002002887e-05 NA NA NA hsa-miR-186-5p FGFR2 0.149964130725901 0.434709542998771 -0.0989978709215018 0.814042278338263 miRNAWalker2_validate -0.416290327670683 0.00939242147576651 NA NA NA hsa-miR-326 FGFR2 -0.429748586406214 0.2629894124021 -0.0989978709215018 0.814042278338263 miRanda -0.227787287684123 0.00384928442941226 NA NA NA hsa-miR-338-3p FGFR2 -0.959276231066179 0.0191473351014091 -0.0989978709215018 0.814042278338263 miRanda;miRNATAP -0.196178980077981 0.00698122481372059 NA NA NA hsa-miR-194-5p FGFR3 -0.127742909829168 0.906065815804667 1.65518678016625 0.0043355270123643 miRNATAP -0.225086870713638 1.12067768221423e-09 NA NA NA hsa-miR-532-5p FGFR3 0.313080805824184 0.252248939356301 1.65518678016625 0.0043355270123643 mirMAP -0.433951889263385 0.0047914041475262 NA NA NA hsa-miR-100-5p FLT1 -0.909635282943505 0.0262703445792608 -0.305628570833107 0.338279360820836 miRNAWalker2_validate;miRTarBase -0.144645999080795 0.00881472847765584 NA NA NA hsa-miR-149-5p FLT1 0.706277554734069 0.296848731347677 -0.305628570833107 0.338279360820836 MirTarget -0.184807386146691 1.08019816320546e-08 NA NA NA hsa-miR-224-5p FLT1 2.7648036144402 0.000111736336240167 -0.305628570833107 0.338279360820836 mirMAP -0.114667969204663 0.000193997297726446 NA NA NA hsa-miR-24-3p FLT1 1.08578167539644 6.18549359075268e-07 -0.305628570833107 0.338279360820836 miRNATAP -0.3879085895128 0.000142028146197539 NA NA NA hsa-miR-708-5p FLT1 1.41830449251856 0.0109647946476309 -0.305628570833107 0.338279360820836 MirTarget -0.149095875231464 0.000191499476944778 NA NA NA hsa-miR-744-3p FLT1 1.40439584998788 0.000973603203532439 -0.305628570833107 0.338279360820836 MirTarget -0.158837536398904 0.00255291103967256 NA NA NA hsa-miR-944 FLT1 3.33123095809751 0.0177835044930391 -0.305628570833107 0.338279360820836 mirMAP;miRNATAP -0.103734422607415 1.83664150134639e-08 NA NA NA hsa-miR-139-5p FN1 -1.83374360776637 1.22019901002824e-09 0.118836029927559 0.829908309383186 miRanda -0.51636898560642 3.04507510907817e-05 NA NA NA hsa-miR-144-3p FN1 -0.13309578176575 0.798245647923351 0.118836029927559 0.829908309383186 MirTarget -0.252389637466052 0.000897770062121993 NA NA NA hsa-miR-16-1-3p FN1 1.43227522002564 3.70920454953168e-08 0.118836029927559 0.829908309383186 mirMAP -0.545258732831528 0.000188816652957985 NA NA NA hsa-miR-200b-3p FN1 0.974577911407732 0.0595020056914543 0.118836029927559 0.829908309383186 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.500583267105701 3.26699028080128e-12 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-200c-3p FN1 1.28185685499076 0.00369777635539177 0.118836029927559 0.829908309383186 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.52568201780896 5.80464696284483e-10 NA NA NA hsa-miR-26b-5p FN1 -0.301646326928219 0.160081421968103 0.118836029927559 0.829908309383186 miRNAWalker2_validate -0.754075084753485 4.35846957381142e-05 NA NA NA hsa-miR-27a-5p FN1 1.09051796355562 0.00189340505433517 0.118836029927559 0.829908309383186 MirTarget -0.358871489517563 0.00119929858485285 NA NA NA hsa-miR-320a FN1 0.593888711838028 0.011897419390526 0.118836029927559 0.829908309383186 miRanda -0.514896418842924 0.00212462852007981 NA NA NA hsa-miR-320b FN1 1.11183660885284 0.000497971211648503 0.118836029927559 0.829908309383186 miRanda -0.432255699600111 0.000366424407111178 NA NA NA hsa-miR-320c FN1 0.455072851945474 0.240613785444485 0.118836029927559 0.829908309383186 miRanda -0.34947516775191 0.00294649198012234 NA NA NA hsa-miR-33a-3p FN1 0.347011402017138 0.321709379745392 0.118836029927559 0.829908309383186 mirMAP -0.50597307902061 1.52742404669564e-05 NA NA NA hsa-miR-429 FN1 1.40182602301928 0.00900426780286475 0.118836029927559 0.829908309383186 MirTarget;PITA;miRanda;miRNATAP -0.467072109634058 1.47471377104424e-11 NA NA NA hsa-miR-590-3p FN1 1.11654983899947 0.000160782154924864 0.118836029927559 0.829908309383186 miRanda;mirMAP -0.425521200588534 0.00118012490517232 NA NA NA hsa-miR-615-3p FN1 2.82967143704683 3.05118423223543e-05 0.118836029927559 0.829908309383186 miRNAWalker2_validate -0.222586148788799 0.00469866439311566 NA NA NA hsa-miR-96-5p FN1 1.14243043653372 0.00942969392739105 0.118836029927559 0.829908309383186 MirTarget;TargetScan -0.242716173186797 0.00922070975605794 NA NA NA hsa-let-7a-3p FOXO3 0.503048155002889 0.0411145454335299 -0.845121155009882 7.67183969352449e-07 mirMAP;miRNATAP -0.154060398200102 0.00244408820263752 NA NA NA hsa-let-7b-3p FOXO3 0.21838629112113 0.296038413622566 -0.845121155009882 7.67183969352449e-07 mirMAP;miRNATAP -0.159530245579644 0.00871438728779357 NA NA NA hsa-let-7f-1-3p FOXO3 1.28704406797397 1.17954701106157e-06 -0.845121155009882 7.67183969352449e-07 mirMAP -0.158614749959727 0.000535994868845855 NA NA NA hsa-miR-103a-3p FOXO3 0.840525139266028 5.83536475789158e-07 -0.845121155009882 7.67183969352449e-07 mirMAP -0.234161088365764 0.00155275353675364 NA NA NA hsa-miR-182-5p FOXO3 0.887369486030646 0.0310640781418789 -0.845121155009882 7.67183969352449e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.102209520225704 0.00063906006974261 24519909;24865442;19188590 Sp1 increased expression of miR-182 which was then recruited to the 3'-untranslated region of FOXO3 mRNA to silence its translational activity; Repression of FOXO3 expression in the miR-182 knockdown cells partially reversed this effect suggesting that miR-182 promotes cancer cell growth and inhibits cancer metastatic activity by regulating the expression of FOXO3; In conclusion in the early stages of lung cancer progression Sp1 stimulates miR-182 expression which in turn decreases FOXO3 expression; In the late stages Sp1 and miR-182 decline thus increasing FOXO3 expression which leads to lung metastasis;Immunohistochemical analysis revealed that the levels of FOXO1 and FOXO3A two potential miR-182 targets are reduced in AA tumors;Aberrant miR 182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia associated transcription factor; We further show that miR-182 over-expression promotes migration and survival by directly repressing microphthalmia-associated transcription factor-M and FOXO3 whereas enhanced expression of either microphthalmia-associated transcription factor-M or FOXO3 blocks miR-182's proinvasive effects; In human tissues expression of miR-182 increases with progression from primary to metastatic melanoma and inversely correlates with FOXO3 and microphthalmia-associated transcription factor levels staging;progression;metastasis;;metastasis;poor survival;progression lung cancer;colon cancer;melanoma hsa-miR-197-3p FOXO3 0.888854270009261 0.000195183808214449 -0.845121155009882 7.67183969352449e-07 miRNAWalker2_validate -0.135103985962581 0.009442733396842 NA NA NA hsa-miR-23a-3p FOXO3 1.10685926969665 3.16223452471768e-08 -0.845121155009882 7.67183969352449e-07 miRNAWalker2_validate;miRTarBase -0.323799249045571 5.25884901296685e-08 NA NA NA hsa-miR-27a-3p FOXO3 1.29886998470345 2.68986118553486e-08 -0.845121155009882 7.67183969352449e-07 miRNATAP -0.237830751007458 3.2047208031521e-06 23621269 FOXO3a was verified as a new target of miR-27a by Western blotting and reporter analyzes glioblastoma hsa-miR-27b-3p FOXO3 0.0836323965901755 0.725273923274 -0.845121155009882 7.67183969352449e-07 miRNATAP -0.160090574046006 0.00251330368118355 NA NA NA hsa-miR-301a-3p FOXO3 1.44721900431161 6.35068481036652e-06 -0.845121155009882 7.67183969352449e-07 mirMAP -0.129924651214051 0.000592579470985126 NA NA NA hsa-miR-744-5p FOXO3 1.0861545801627 0.000122087743268849 -0.845121155009882 7.67183969352449e-07 miRNAWalker2_validate -0.147961466997251 0.000641405562074758 NA NA NA hsa-miR-92b-3p FOXO3 1.33518446513417 1.45350885391576e-06 -0.845121155009882 7.67183969352449e-07 mirMAP -0.159833252083512 0.000251954081474763 NA NA NA hsa-miR-940 FOXO3 1.64406174271686 0.000690854900107004 -0.845121155009882 7.67183969352449e-07 miRNATAP -0.104124761455495 0.000466754324432182 NA NA NA hsa-miR-199a-5p G6PC3 0.371973504507027 0.232661597228763 0.138840645244849 0.561895754456422 miRNATAP -0.198108671883136 0.000264360255978364 NA NA NA hsa-miR-199b-5p G6PC3 0.124595928096068 0.678156859366405 0.138840645244849 0.561895754456422 miRNATAP -0.154249940362902 0.0067617647399839 NA NA NA hsa-let-7g-5p GHR 0.325297685027927 0.241142963826631 -2.83614122468118 2.56011796824058e-06 miRNATAP -0.444885482782847 0.00552639828995174 NA NA NA hsa-miR-126-5p GHR 0.41765430251855 0.0753161203651532 -2.83614122468118 2.56011796824058e-06 MirTarget;mirMAP -0.525310623057796 0.00575916170779591 NA NA NA hsa-miR-142-3p GHR 1.32364054836498 0.0001537753622128 -2.83614122468118 2.56011796824058e-06 MirTarget;PITA;miRanda;miRNATAP -0.322873877777482 0.00955367274486855 NA NA NA hsa-miR-15a-5p GHR 1.03783090449383 7.40334108980898e-07 -2.83614122468118 2.56011796824058e-06 MirTarget;miRNATAP -0.718884560748438 0.00052069316192807 NA NA NA hsa-miR-15b-5p GHR 1.62046407540723 5.42152621571078e-09 -2.83614122468118 2.56011796824058e-06 MirTarget;miRNATAP -0.529274291413705 0.000530727722860748 NA NA NA hsa-miR-16-2-3p GHR 1.8048179609245 2.83095715136409e-09 -2.83614122468118 2.56011796824058e-06 mirMAP -0.458746467394034 0.000993883987590111 NA NA NA hsa-miR-16-5p GHR 1.00515772948091 5.33912942007619e-06 -2.83614122468118 2.56011796824058e-06 MirTarget;miRNATAP -0.698056825924518 0.000394376718044677 NA NA NA hsa-miR-29a-5p GHR 0.585084040404152 0.023014129158495 -2.83614122468118 2.56011796824058e-06 mirMAP;miRNATAP -0.973713867459453 5.2518717619226e-09 NA NA NA hsa-miR-338-5p GHR -1.19659203838734 0.0100316010080496 -2.83614122468118 2.56011796824058e-06 PITA -0.473026572446891 2.66744291668657e-07 NA NA NA hsa-miR-421 GHR 1.80720854070385 1.59709651202848e-07 -2.83614122468118 2.56011796824058e-06 miRanda -0.405372661550727 0.00104463368043836 NA NA NA hsa-miR-429 GHR 1.40182602301928 0.00900426780286475 -2.83614122468118 2.56011796824058e-06 miRanda;miRNATAP -0.371251650813614 3.44980741686856e-06 NA NA NA hsa-miR-624-5p GHR 1.03467956701702 0.0010908013402586 -2.83614122468118 2.56011796824058e-06 MirTarget -0.384262764917071 0.00872966743561295 NA NA NA hsa-miR-7-1-3p GHR 0.709309110750947 0.0412301737463194 -2.83614122468118 2.56011796824058e-06 MirTarget;mirMAP -0.746505847723966 9.96486525090052e-10 NA NA NA hsa-miR-126-5p GNB4 0.41765430251855 0.0753161203651532 -0.21175622394543 0.603353968429849 mirMAP -0.529774519793596 1.70510513243194e-05 NA NA NA hsa-miR-140-3p GNB4 -0.296251775392129 0.127539826012144 -0.21175622394543 0.603353968429849 MirTarget -0.516692025368155 0.00066721631620101 NA NA NA hsa-miR-186-5p GNB4 0.149964130725901 0.434709542998771 -0.21175622394543 0.603353968429849 MirTarget -0.563819737170919 0.000248498907464407 NA NA NA hsa-miR-29a-3p GNB4 -0.113012156986374 0.615005009685815 -0.21175622394543 0.603353968429849 MirTarget -0.578856677853384 7.51132369936815e-06 NA NA NA hsa-miR-29b-3p GNB4 -0.230693226193598 0.367461626035234 -0.21175622394543 0.603353968429849 MirTarget -0.455506558775273 5.82003804275857e-05 NA NA NA hsa-miR-338-5p GNB4 -1.19659203838734 0.0100316010080496 -0.21175622394543 0.603353968429849 MirTarget -0.313084311693515 2.10801705551083e-07 NA NA NA hsa-miR-33a-3p GNB4 0.347011402017138 0.321709379745392 -0.21175622394543 0.603353968429849 MirTarget -0.364023079603871 2.43469227065651e-05 NA NA NA hsa-miR-429 GNB4 1.40182602301928 0.00900426780286475 -0.21175622394543 0.603353968429849 miRanda -0.400573709437329 8.14257043622777e-16 NA NA NA hsa-miR-501-5p GNB4 0.266919328110625 0.454779001968586 -0.21175622394543 0.603353968429849 mirMAP -0.461980343448947 4.30475885649682e-09 NA NA NA hsa-miR-7-1-3p GNB4 0.709309110750947 0.0412301737463194 -0.21175622394543 0.603353968429849 MirTarget -0.601976307796118 1.22640253683285e-14 NA NA NA hsa-miR-877-5p GNB4 2.17859965442336 1.03593450648516e-07 -0.21175622394543 0.603353968429849 MirTarget -0.298680776737718 9.19722992507621e-06 NA NA NA hsa-miR-130b-3p GNB5 1.32714007211004 4.78676252285191e-05 0.00752956764213852 0.971809729265749 miRNAWalker2_validate -0.135578490630467 0.00281883585116708 NA NA NA hsa-miR-148a-3p GNB5 -1.53721533763578 3.55533747293117e-05 0.00752956764213852 0.971809729265749 miRNAWalker2_validate -0.17677274524096 6.30743874451622e-06 NA NA NA hsa-miR-17-5p GNB5 1.65862087862483 8.45603406215941e-08 0.00752956764213852 0.971809729265749 TargetScan -0.128854045850957 0.00641088433761162 NA NA NA hsa-miR-338-3p GNB5 -0.959276231066179 0.0191473351014091 0.00752956764213852 0.971809729265749 miRanda -0.155423052296047 1.67068797514615e-05 NA NA NA hsa-miR-425-5p GNB5 1.13924952403101 0.000255357546232931 0.00752956764213852 0.971809729265749 miRNAWalker2_validate -0.176400814019148 0.000204502477491449 NA NA NA hsa-miR-429 GNB5 1.40182602301928 0.00900426780286475 0.00752956764213852 0.971809729265749 miRanda -0.151368187892592 1.9962881452872e-08 NA NA NA hsa-miR-107 GNG12 0.904627575346218 4.67936495073904e-05 -0.294101873698593 0.112771340553714 miRanda -0.200412767237989 0.000630268384679819 NA NA NA hsa-miR-126-5p GNG12 0.41765430251855 0.0753161203651532 -0.294101873698593 0.112771340553714 mirMAP -0.156388609985589 0.0057405609112311 NA NA NA hsa-miR-140-5p GNG12 0.208193069681326 0.303002433893804 -0.294101873698593 0.112771340553714 PITA;miRanda -0.252822882443761 0.000124004811884371 NA NA NA hsa-miR-374b-5p GNG12 -0.188120735251554 0.394800117237392 -0.294101873698593 0.112771340553714 mirMAP -0.174991830772569 0.00379237778781347 NA NA NA hsa-miR-423-5p GNG12 0.832613878736338 0.000791321227103338 -0.294101873698593 0.112771340553714 miRNAWalker2_validate -0.240235936972391 3.80058099265444e-06 NA NA NA hsa-miR-590-3p GNG12 1.11654983899947 0.000160782154924864 -0.294101873698593 0.112771340553714 miRanda;mirMAP -0.121726190652431 0.00559991009386133 NA NA NA hsa-miR-590-5p GNG12 1.04171442093217 0.000272475544954865 -0.294101873698593 0.112771340553714 PITA -0.130764537784798 0.00404814498177005 NA NA NA hsa-miR-23a-3p GNG2 1.10685926969665 3.16223452471768e-08 -0.36392009320106 0.264619871146767 miRNATAP -0.391321108423012 0.000567944429330178 NA NA NA hsa-miR-23b-3p GNG2 -0.286465516491361 0.18664668472995 -0.36392009320106 0.264619871146767 miRNATAP -0.320627669163308 0.00319374792190231 NA NA NA hsa-miR-3065-5p GNG2 -0.241623656423063 0.633116553078159 -0.36392009320106 0.264619871146767 mirMAP;miRNATAP -0.165149640492123 0.000400398874848712 NA NA NA hsa-miR-335-3p GNG2 2.5197689063267 2.20084506976733e-09 -0.36392009320106 0.264619871146767 mirMAP -0.140220705544017 0.00786726203377881 NA NA NA hsa-miR-429 GNG2 1.40182602301928 0.00900426780286475 -0.36392009320106 0.264619871146767 miRanda;miRNATAP -0.192009989118279 5.05976261984203e-06 NA NA NA hsa-miR-576-5p GNG2 0.625714137488957 0.0417100301848969 -0.36392009320106 0.264619871146767 mirMAP -0.202102185689406 0.00759361179797321 NA NA NA hsa-miR-590-5p GNG2 1.04171442093217 0.000272475544954865 -0.36392009320106 0.264619871146767 miRanda;miRNATAP -0.274301295213188 0.00060722336088799 NA NA NA hsa-miR-192-3p GNG4 0.355565421687399 0.74117031340037 -0.292817690722517 0.752274685320027 MirTarget -0.364674344868212 1.07019665834202e-09 NA NA NA hsa-miR-200a-3p GNG4 0.717826667295984 0.193912116506827 -0.292817690722517 0.752274685320027 mirMAP -0.438810884002929 0.000204120579501834 NA NA NA hsa-miR-200b-3p GNG4 0.974577911407732 0.0595020056914543 -0.292817690722517 0.752274685320027 mirMAP -0.438818774747985 0.000511420878206377 NA NA NA hsa-miR-338-3p GNG4 -0.959276231066179 0.0191473351014091 -0.292817690722517 0.752274685320027 miRanda -0.796032251990307 3.80708496561738e-07 NA NA NA hsa-miR-429 GNG4 1.40182602301928 0.00900426780286475 -0.292817690722517 0.752274685320027 mirMAP -0.390110601035772 0.00131414397722242 NA NA NA hsa-miR-199a-5p GNG5 0.371973504507027 0.232661597228763 0.0760959044090024 0.667214339294949 MirTarget;miRanda;miRNATAP -0.225385306625696 7.21762479482505e-09 NA NA NA hsa-miR-199b-5p GNG5 0.124595928096068 0.678156859366405 0.0760959044090024 0.667214339294949 MirTarget;miRanda;miRNATAP -0.177376310657559 1.76689098459512e-05 NA NA NA hsa-miR-1254 GNG7 0.941374574140312 0.0605480748500796 -3.4565296709262 6.28535535483384e-12 miRNATAP -0.375539534022685 2.88003797639596e-05 NA NA NA hsa-miR-1271-5p GNG7 1.15538250415776 0.00207865862606828 -3.4565296709262 6.28535535483384e-12 mirMAP -0.263765152421519 0.00952810755390318 NA NA NA hsa-miR-141-3p GNG7 1.45548825076434 0.00115958850961764 -3.4565296709262 6.28535535483384e-12 MirTarget;TargetScan;miRNATAP -0.495816263696205 7.26806862953206e-10 NA NA NA hsa-miR-17-3p GNG7 1.31126744284937 3.24768335024185e-07 -3.4565296709262 6.28535535483384e-12 mirMAP -0.779599286745246 2.95691362969474e-08 NA NA NA hsa-miR-182-5p GNG7 0.887369486030646 0.0310640781418789 -3.4565296709262 6.28535535483384e-12 mirMAP -0.488173315809994 4.5612941659672e-08 NA NA NA hsa-miR-185-3p GNG7 1.33711019171256 3.45756583967985e-05 -3.4565296709262 6.28535535483384e-12 mirMAP -0.666905647454356 2.33102713290999e-09 NA NA NA hsa-miR-18a-3p GNG7 2.35188582849667 1.39401350286321e-08 -3.4565296709262 6.28535535483384e-12 mirMAP -0.578103482263822 5.74785706512557e-12 NA NA NA hsa-miR-18a-5p GNG7 2.20211504140984 1.78678887916334e-09 -3.4565296709262 6.28535535483384e-12 mirMAP -0.609594609776221 1.58838071424393e-10 NA NA NA hsa-miR-193b-5p GNG7 0.609581100028941 0.13923921336815 -3.4565296709262 6.28535535483384e-12 mirMAP -0.502340798433604 1.78569939058345e-08 NA NA NA hsa-miR-200a-3p GNG7 0.717826667295984 0.193912116506827 -3.4565296709262 6.28535535483384e-12 MirTarget;miRNATAP -0.201196903885862 0.00325418058864664 NA NA NA hsa-miR-22-5p GNG7 0.804348748654247 0.000804065112767412 -3.4565296709262 6.28535535483384e-12 mirMAP -0.416271323093906 0.00861328608320733 NA NA NA hsa-miR-224-5p GNG7 2.7648036144402 0.000111736336240167 -3.4565296709262 6.28535535483384e-12 mirMAP -0.241515148302505 2.1128035922729e-06 NA NA NA hsa-miR-23a-3p GNG7 1.10685926969665 3.16223452471768e-08 -3.4565296709262 6.28535535483384e-12 mirMAP -0.896968058742437 9.41743357621311e-07 NA NA NA hsa-miR-31-3p GNG7 0.474904754927656 0.506866261575484 -3.4565296709262 6.28535535483384e-12 mirMAP -0.181490167241839 0.000620089034431963 NA NA NA hsa-miR-31-5p GNG7 0.666358292391859 0.381800494600846 -3.4565296709262 6.28535535483384e-12 mirMAP -0.200242711547866 0.000112260834993831 NA NA NA hsa-miR-3127-5p GNG7 0.98677589413294 0.00734249049849 -3.4565296709262 6.28535535483384e-12 mirMAP -0.365501244326962 0.000345915539351558 NA NA NA hsa-miR-323b-3p GNG7 1.13581624461921 0.0214847831286342 -3.4565296709262 6.28535535483384e-12 mirMAP -0.344117888424896 5.54388473559741e-05 NA NA NA hsa-miR-3615 GNG7 1.25850728223629 0.000102643804657077 -3.4565296709262 6.28535535483384e-12 mirMAP -0.568688463012534 4.8714178174758e-07 NA NA NA hsa-miR-590-3p GNG7 1.11654983899947 0.000160782154924864 -3.4565296709262 6.28535535483384e-12 PITA;miRanda;mirMAP -0.363008965804527 0.00424025361252838 NA NA NA hsa-miR-616-5p GNG7 0.834052908652744 0.0347835664029363 -3.4565296709262 6.28535535483384e-12 MirTarget -0.312833515977665 0.00130027277417549 NA NA NA hsa-miR-671-5p GNG7 0.947458646379882 0.0024732430914236 -3.4565296709262 6.28535535483384e-12 mirMAP -0.519315073011342 1.25877563516228e-05 NA NA NA hsa-miR-92a-3p GNG7 1.2209325870225 6.8757197708107e-06 -3.4565296709262 6.28535535483384e-12 miRNAWalker2_validate -0.884545394720387 1.60756395882906e-11 NA NA NA hsa-miR-939-5p GNG7 0.857156740351386 0.0124815824643173 -3.4565296709262 6.28535535483384e-12 mirMAP -0.568213928667562 1.72583932749064e-06 NA NA NA hsa-miR-940 GNG7 1.64406174271686 0.000690854900107004 -3.4565296709262 6.28535535483384e-12 MirTarget -0.390314124027094 1.47397804630475e-05 NA NA NA hsa-miR-96-5p GNG7 1.14243043653372 0.00942969392739105 -3.4565296709262 6.28535535483384e-12 mirMAP -0.516933724306247 2.47250678001813e-09 NA NA NA hsa-miR-29a-5p GNGT1 0.585084040404152 0.023014129158495 2.97304746826854 0.00013849587261965 mirMAP -0.64293588134879 0.00360033672657742 NA NA NA hsa-miR-219a-1-3p GNGT2 1.25987698719907 0.000462608426981798 0.351965126193358 0.317137720452162 MirTarget -0.274844342976407 5.51276980599983e-05 NA NA NA hsa-miR-101-3p GSK3B -0.451263906815861 0.0283387250173031 0.173686703054757 0.358761637442374 miRNATAP -0.309746385838821 1.76772309214892e-06 NA NA NA hsa-miR-212-3p GSK3B 0.960352937108106 0.00133449812322732 0.173686703054757 0.358761637442374 mirMAP;miRNATAP -0.157580688036431 0.000373666664591505 NA NA NA hsa-miR-26a-5p GSK3B -0.384110714440647 0.0442498636014044 0.173686703054757 0.358761637442374 miRNAWalker2_validate;miRNATAP -0.297404702806196 2.62046086511681e-05 NA NA NA hsa-miR-26b-5p GSK3B -0.301646326928219 0.160081421968103 0.173686703054757 0.358761637442374 miRNATAP -0.202543608293146 0.00135911800763895 NA NA NA hsa-miR-29a-3p GSK3B -0.113012156986374 0.615005009685815 0.173686703054757 0.358761637442374 miRNATAP -0.237953626141529 7.3117565138463e-05 NA NA NA hsa-miR-29b-3p GSK3B -0.230693226193598 0.367461626035234 0.173686703054757 0.358761637442374 miRTarBase;miRNATAP -0.139976205675035 0.00818133109022919 NA NA NA hsa-miR-29c-3p GSK3B -1.62454036584589 5.38376515586029e-07 0.173686703054757 0.358761637442374 miRNATAP -0.149008148419369 0.000186841384822779 NA NA NA hsa-miR-30d-3p GSK3B -0.545113326540761 0.0433733076874155 0.173686703054757 0.358761637442374 miRNATAP -0.134805668946892 0.00688448679166308 NA NA NA hsa-miR-340-5p GSK3B -0.164941927483643 0.529910509321278 0.173686703054757 0.358761637442374 mirMAP -0.184933292640156 0.000302021889990012 NA NA NA hsa-miR-29b-2-5p GYS1 -1.7015307882027 2.84239251703401e-10 0.0327584743291682 0.851214757057571 MirTarget -0.205392461406746 1.79343343016163e-06 NA NA NA hsa-miR-423-5p GYS1 0.832613878736338 0.000791321227103338 0.0327584743291682 0.851214757057571 MirTarget -0.181827556541901 0.000220486422942508 NA NA NA hsa-miR-491-5p GYS1 -0.693578126269305 0.0313646742330058 0.0327584743291682 0.851214757057571 miRanda -0.102704582988835 0.0086487806572438 NA NA NA hsa-let-7a-3p HGF 0.503048155002889 0.0411145454335299 -0.376531570639447 0.550491511103826 mirMAP -0.818691872864681 6.02516795359655e-06 NA NA NA hsa-let-7b-3p HGF 0.21838629112113 0.296038413622566 -0.376531570639447 0.550491511103826 mirMAP -0.849666066489082 9.15421436976392e-05 NA NA NA hsa-miR-141-3p HGF 1.45548825076434 0.00115958850961764 -0.376531570639447 0.550491511103826 MirTarget;TargetScan -0.486507123512748 4.89226986811595e-07 NA NA NA hsa-miR-203a-3p HGF 1.44736908507496 0.0394116388736904 -0.376531570639447 0.550491511103826 MirTarget -0.518782559309176 3.06524300072984e-19 NA NA NA hsa-miR-224-3p HGF 1.52422171450716 0.00650463542340912 -0.376531570639447 0.550491511103826 mirMAP -0.463827973319244 4.02273153083653e-08 NA NA NA hsa-miR-33a-3p HGF 0.347011402017138 0.321709379745392 -0.376531570639447 0.550491511103826 mirMAP -0.544350013780391 4.75735535202373e-05 NA NA NA hsa-miR-34c-5p HGF 2.20632574870337 0.000379662996168678 -0.376531570639447 0.550491511103826 miRanda -0.305112726593846 1.53268570245237e-05 NA NA NA hsa-miR-3682-3p HGF 1.96838261925327 4.94885331227292e-06 -0.376531570639447 0.550491511103826 mirMAP -0.404404600221883 0.000774301762513964 NA NA NA hsa-miR-590-5p HGF 1.04171442093217 0.000272475544954865 -0.376531570639447 0.550491511103826 miRanda -0.577047667344204 0.000185605077930884 NA NA NA hsa-miR-944 HGF 3.33123095809751 0.0177835044930391 -0.376531570639447 0.550491511103826 mirMAP -0.251904679029854 1.61296788568438e-12 NA NA NA hsa-miR-30c-5p HSP90AA1 -0.983130268805942 4.60419218706127e-05 0.812374957912846 5.3174477840451e-05 miRNAWalker2_validate -0.204471936079187 0.000581402148304355 NA NA NA hsa-miR-30e-5p HSP90AA1 -0.573784818166736 0.0112497802572927 0.812374957912846 5.3174477840451e-05 miRNAWalker2_validate -0.194038190447526 0.00267282395204826 NA NA NA hsa-miR-152-3p HSP90B1 0.436002345388935 0.161701199884702 0.620751385056549 0.000111831524139515 MirTarget -0.134002884963372 0.00028244930748863 NA NA NA hsa-miR-129-5p IBSP -2.56914016541176 2.36237896095709e-06 5.30164501058247 2.20059557855735e-13 miRanda -0.295576247913893 0.00306644873206708 25344911 Using microarray and BSP Bisulfate Sequencing PCR assays we found that compared with the parent SGC7901/VCR cells expression of miR-129-5p was restored in SGC7901/VCR gastric cancer multi-drug resistant cell line treated by de-methylation reagent 5-AZA-dC gastric cancer hsa-miR-139-5p IBSP -1.83374360776637 1.22019901002824e-09 5.30164501058247 2.20059557855735e-13 miRanda -0.952115581448327 2.17932720009627e-08 NA NA NA hsa-miR-17-3p IFNAR1 1.31126744284937 3.24768335024185e-07 -0.539209866274569 0.000275139740559387 mirMAP -0.15375232755934 0.000123114047873166 NA NA NA hsa-miR-320b IFNAR1 1.11183660885284 0.000497971211648503 -0.539209866274569 0.000275139740559387 mirMAP -0.116734552782754 0.000349580201541442 NA NA NA hsa-miR-361-5p IFNAR1 0.407725414130987 0.0181260969156347 -0.539209866274569 0.000275139740559387 miRanda -0.236826053405391 0.000154843793731808 NA NA NA hsa-miR-3913-5p IFNAR1 0.878857760706319 0.00310224428304055 -0.539209866274569 0.000275139740559387 mirMAP -0.10836636054715 0.00236936913498482 NA NA NA hsa-miR-452-5p IFNAR1 2.08756506185889 0.000258095769002813 -0.539209866274569 0.000275139740559387 mirMAP -0.107349586469772 8.92454492751194e-10 NA NA NA hsa-miR-484 IFNAR1 0.71327898984355 0.00233605130771196 -0.539209866274569 0.000275139740559387 miRNATAP -0.143880077283194 0.00147602394264695 NA NA NA hsa-miR-1271-5p IFNAR2 1.15538250415776 0.00207865862606828 0.463466879196117 0.014289019910094 mirMAP -0.147733144694323 3.31540499636322e-05 NA NA NA hsa-miR-224-3p IFNAR2 1.52422171450716 0.00650463542340912 0.463466879196117 0.014289019910094 mirMAP -0.144133338906927 1.15224442570249e-08 NA NA NA hsa-let-7a-3p IGF1 0.503048155002889 0.0411145454335299 -2.08273193234781 0.00135003721777342 mirMAP -0.548762647030196 0.00421892046856383 NA NA NA hsa-let-7b-3p IGF1 0.21838629112113 0.296038413622566 -2.08273193234781 0.00135003721777342 mirMAP -0.635547835878874 0.00549026374201425 NA NA NA hsa-let-7f-1-3p IGF1 1.28704406797397 1.17954701106157e-06 -2.08273193234781 0.00135003721777342 mirMAP -0.851363397411719 5.26675622894171e-07 NA NA NA hsa-miR-103a-2-5p IGF1 0.808041560899298 0.019989162317947 -2.08273193234781 0.00135003721777342 mirMAP -0.553669997923913 3.26136051419373e-05 NA NA NA hsa-miR-130b-3p IGF1 1.32714007211004 4.78676252285191e-05 -2.08273193234781 0.00135003721777342 MirTarget -0.899465743270437 2.58112149375995e-11 NA NA NA hsa-miR-15b-3p IGF1 1.75738933306437 3.00554466232543e-08 -2.08273193234781 0.00135003721777342 mirMAP -0.968826693204176 7.96214227786153e-13 NA NA NA hsa-miR-16-1-3p IGF1 1.43227522002564 3.70920454953168e-08 -2.08273193234781 0.00135003721777342 mirMAP -0.890729087705412 1.88566016831073e-07 NA NA NA hsa-miR-181b-5p IGF1 1.64216500592669 1.89228845300725e-08 -2.08273193234781 0.00135003721777342 mirMAP -0.484722871486351 0.00175444902634641 NA NA NA hsa-miR-186-5p IGF1 0.149964130725901 0.434709542998771 -2.08273193234781 0.00135003721777342 mirMAP -0.854024244188329 0.000614672571310158 NA NA NA hsa-miR-19a-3p IGF1 1.26669687448473 0.000105972838514412 -2.08273193234781 0.00135003721777342 MirTarget -0.774005120681808 1.66575604220791e-08 NA NA NA hsa-miR-19b-1-5p IGF1 1.38738648038895 1.3113681938066e-06 -2.08273193234781 0.00135003721777342 mirMAP -0.926821468239418 1.88689070400957e-09 NA NA NA hsa-miR-19b-3p IGF1 0.759818275708988 0.00652779573186786 -2.08273193234781 0.00135003721777342 MirTarget -0.817907622748148 6.24186432835086e-07 NA NA NA hsa-miR-20a-3p IGF1 1.13957127410163 0.000451087640268489 -2.08273193234781 0.00135003721777342 mirMAP -0.98528355307319 2.65793420646273e-13 NA NA NA hsa-miR-27a-3p IGF1 1.29886998470345 2.68986118553486e-08 -2.08273193234781 0.00135003721777342 miRNAWalker2_validate;miRTarBase -0.616931404496154 0.00158345718629553 NA NA NA hsa-miR-301a-3p IGF1 1.44721900431161 6.35068481036652e-06 -2.08273193234781 0.00135003721777342 MirTarget -0.441884252991246 0.00198755452375828 NA NA NA hsa-miR-301b-3p IGF1 1.10080095582241 0.0715568440482997 -2.08273193234781 0.00135003721777342 MirTarget -0.489626457605712 1.80285281431259e-06 NA NA NA hsa-miR-3065-5p IGF1 -0.241623656423063 0.633116553078159 -2.08273193234781 0.00135003721777342 mirMAP -0.280592172239543 0.00303638700940348 NA NA NA hsa-miR-32-3p IGF1 0.583525764322974 0.11837203008551 -2.08273193234781 0.00135003721777342 mirMAP -0.526531906386405 0.000169656014507106 NA NA NA hsa-miR-320a IGF1 0.593888711838028 0.011897419390526 -2.08273193234781 0.00135003721777342 miRNATAP -0.565003176356916 0.00470570622795822 NA NA NA hsa-miR-320b IGF1 1.11183660885284 0.000497971211648503 -2.08273193234781 0.00135003721777342 miRNATAP -0.636268160611304 8.75874676911532e-06 NA NA NA hsa-miR-320c IGF1 0.455072851945474 0.240613785444485 -2.08273193234781 0.00135003721777342 miRNATAP -0.416076292118249 0.00294415535123176 NA NA NA hsa-miR-33a-3p IGF1 0.347011402017138 0.321709379745392 -2.08273193234781 0.00135003721777342 MirTarget -0.68230953278373 8.05008237434513e-07 NA NA NA hsa-miR-3662 IGF1 1.82780708047676 0.0054036501346178 -2.08273193234781 0.00135003721777342 MirTarget -0.445685489349264 6.10879019924172e-07 NA NA NA hsa-miR-421 IGF1 1.80720854070385 1.59709651202848e-07 -2.08273193234781 0.00135003721777342 PITA -0.446185670355332 0.000667970192973034 NA NA NA hsa-miR-454-3p IGF1 0.625199142970745 0.0134890997402741 -2.08273193234781 0.00135003721777342 MirTarget -0.54504877697133 0.00336959864095608 NA NA NA hsa-miR-486-5p IGF1 -0.627607241830911 0.155274583521138 -2.08273193234781 0.00135003721777342 PITA;miRNATAP -0.376922293558939 0.000339259187750958 NA NA NA hsa-miR-576-5p IGF1 0.625714137488957 0.0417100301848969 -2.08273193234781 0.00135003721777342 PITA;mirMAP;miRNATAP -0.758998498936523 3.66567723101284e-07 NA NA NA hsa-miR-577 IGF1 0.911619788986754 0.2256062124148 -2.08273193234781 0.00135003721777342 PITA -0.356762409648375 6.35759889251154e-09 NA NA NA hsa-miR-590-3p IGF1 1.11654983899947 0.000160782154924864 -2.08273193234781 0.00135003721777342 MirTarget;miRanda;mirMAP;miRNATAP -0.61013399064959 8.43840390366035e-05 NA NA NA hsa-miR-592 IGF1 0.779567202789068 0.204498177014474 -2.08273193234781 0.00135003721777342 mirMAP -0.405253750267835 3.79197293554194e-07 NA NA NA hsa-miR-629-5p IGF1 1.06377074768516 0.000536624707722274 -2.08273193234781 0.00135003721777342 mirMAP -0.88383980266392 1.46631776640132e-09 NA NA NA hsa-miR-940 IGF1 1.64406174271686 0.000690854900107004 -2.08273193234781 0.00135003721777342 MirTarget;PITA;miRNATAP -0.451608062622453 5.12340787556199e-05 NA NA NA hsa-let-7f-5p IGF1R 0.634633924115866 0.0344982923411787 -0.553106517250428 0.17432701125411 MirTarget;miRNATAP -0.378400961303142 7.89887847888491e-05 NA NA NA hsa-let-7g-5p IGF1R 0.325297685027927 0.241142963826631 -0.553106517250428 0.17432701125411 MirTarget;miRNATAP -0.544610261720575 1.13359622443088e-07 NA NA NA hsa-miR-140-3p IGF1R -0.296251775392129 0.127539826012144 -0.553106517250428 0.17432701125411 mirMAP -0.422322416904841 0.00570698187046413 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-148a-5p IGF1R -0.69329616490858 0.0793012233740369 -0.553106517250428 0.17432701125411 mirMAP -0.251757326829035 0.000553171225677268 NA NA NA hsa-miR-150-5p IGF1R 0.147461377429675 0.753719621305461 -0.553106517250428 0.17432701125411 mirMAP -0.163158743338605 0.0082548190347579 NA NA NA hsa-miR-15a-5p IGF1R 1.03783090449383 7.40334108980898e-07 -0.553106517250428 0.17432701125411 miRNATAP -0.500409416506016 0.0002318533448516 NA NA NA hsa-miR-181b-5p IGF1R 1.64216500592669 1.89228845300725e-08 -0.553106517250428 0.17432701125411 miRNAWalker2_validate -0.254937673704192 0.00809085905989163 NA NA NA hsa-miR-192-5p IGF1R 0.0809146624034405 0.941057093528709 -0.553106517250428 0.17432701125411 miRNAWalker2_validate -0.192653791844667 5.90020810511349e-15 NA NA NA hsa-miR-194-3p IGF1R 0.259420201261466 0.821811295418686 -0.553106517250428 0.17432701125411 MirTarget -0.176009400808733 1.76136351271372e-13 NA NA NA hsa-miR-194-5p IGF1R -0.127742909829168 0.906065815804667 -0.553106517250428 0.17432701125411 miRNAWalker2_validate;miRTarBase;miRNATAP -0.196168730805129 3.45873170269679e-15 NA NA NA hsa-miR-196a-5p IGF1R 6.59255881689547 1.53691144193899e-22 -0.553106517250428 0.17432701125411 miRNAWalker2_validate -0.166367126909282 9.5163678851203e-06 NA NA NA hsa-miR-215-5p IGF1R 0.715250240418615 0.573784317311889 -0.553106517250428 0.17432701125411 miRNAWalker2_validate -0.168418028237117 1.74687701753203e-15 NA NA NA hsa-miR-30b-5p IGF1R -0.430720743745757 0.0593564057320791 -0.553106517250428 0.17432701125411 mirMAP -0.349035608361065 0.00668842822760847 NA NA NA hsa-miR-30d-5p IGF1R -0.5492586056147 0.0140125082460125 -0.553106517250428 0.17432701125411 mirMAP;miRNATAP -0.495760465497343 0.000137106101767097 NA NA NA hsa-miR-335-3p IGF1R 2.5197689063267 2.20084506976733e-09 -0.553106517250428 0.17432701125411 MirTarget;mirMAP -0.222943394713827 0.000675759476842365 NA NA NA hsa-miR-335-5p IGF1R 1.59953351087307 5.56170899867314e-05 -0.553106517250428 0.17432701125411 miRNAWalker2_validate -0.300660921541017 2.17486872509834e-05 NA NA NA hsa-miR-34a-5p IGF1R 0.794251341270032 0.00024017386701179 -0.553106517250428 0.17432701125411 miRNAWalker2_validate -0.540234381081216 4.83945332854109e-05 NA NA NA hsa-miR-362-3p IGF1R -0.0349414695893027 0.913780708043777 -0.553106517250428 0.17432701125411 PITA -0.286720174854921 0.00151653552950817 NA NA NA hsa-miR-375 IGF1R -2.94506033785642 0.00570147601654791 -0.553106517250428 0.17432701125411 miRNATAP -0.155241010853673 2.05915373743628e-09 21813472;27129171;24571711 Real-time quantitative PCR was applied to detectthe expression of miR-375 in ESCC samples and its correlation with insulin-like growth factor 1 receptor IGF1R; Further study showed that miR-375 could interact with the 3'-untranslated region of IGF1R and downregulate its expression; In clinical specimens the expression of IGF1R was also negatively correlated with miR-375 expression p=0.008; This study demonstrates that miR-375 has a strong tumour-suppressive effect through inhibiting the expression of IGF1R;Together these results show that AE modulates cancer cells and the tumor microenvironment via activation of miR-375 and by targeting IGF1R and SNAIL1 in OC cells;Epigenetic silencing of miR 375 induces trastuzumab resistance in HER2 positive breast cancer by targeting IGF1R; miR-375 which was downregulated and predicted to target IGF1R in trastuzumab-resistant HER2-positive breast cancer cells could indeed inhibit the cellular luciferase activity in a reporter construct containing the 3'-UTR of IGF1R; A reverse correlation between the levels of miR-375 and IGF1R was validated in clinical breast cancers; Epigenetic silencing of miR-375 causes the upregulation of IGF1R which at least partially underlies trastuzumab resistance of breast cancer cells ;;drug resistance esophageal cancer;ovarian cancer;breast cancer hsa-miR-378c IGF1R -1.27752074861415 2.73676010235611e-05 -0.553106517250428 0.17432701125411 MirTarget;miRNATAP -0.331914273565809 0.000369181287609095 NA NA NA hsa-miR-421 IGF1R 1.80720854070385 1.59709651202848e-07 -0.553106517250428 0.17432701125411 miRanda -0.251977703312655 0.00196650565292646 NA NA NA hsa-miR-429 IGF1R 1.40182602301928 0.00900426780286475 -0.553106517250428 0.17432701125411 miRanda;miRNATAP -0.179305798707313 0.000761816738044031 NA NA NA hsa-miR-500a-3p IGF1R 0.133193057420744 0.668896091969871 -0.553106517250428 0.17432701125411 mirMAP -0.348362935548975 0.000179911177701298 NA NA NA hsa-miR-502-5p IGF1R -0.260297419808178 0.520453580478988 -0.553106517250428 0.17432701125411 PITA;miRNATAP -0.217953361026437 0.00252941658268057 NA NA NA hsa-miR-532-5p IGF1R 0.313080805824184 0.252248939356301 -0.553106517250428 0.17432701125411 miRNATAP -0.648603078037439 2.73220033188001e-10 NA NA NA hsa-miR-577 IGF1R 0.911619788986754 0.2256062124148 -0.553106517250428 0.17432701125411 PITA;miRNATAP -0.167215754453568 1.61689028990584e-05 NA NA NA hsa-miR-592 IGF1R 0.779567202789068 0.204498177014474 -0.553106517250428 0.17432701125411 PITA;miRNATAP -0.221271696492091 8.80961634697948e-06 NA NA NA hsa-miR-625-5p IGF1R 0.537211086526376 0.203801009380384 -0.553106517250428 0.17432701125411 MirTarget -0.252376793200635 0.000225376174409542 NA NA NA hsa-miR-7-1-3p IGF1R 0.709309110750947 0.0412301737463194 -0.553106517250428 0.17432701125411 mirMAP -0.352123862385633 1.86985718445879e-05 NA NA NA hsa-miR-7-5p IGF1R 1.63575693499363 0.0124424214624534 -0.553106517250428 0.17432701125411 miRNAWalker2_validate;mirMAP -0.246386046302912 3.53398011198323e-08 22614005 Moreover the insulin-like growth factor-1 receptor IGF1R oncogene which is often mutated or amplified in human cancers and functions as an important regulator of cell growth and tumor invasion was identified as a direct target of miR-7; Silencing of IGF1R using small interefering RNA siRNA recapitulated the anti-metastatic function of miR-7 whereas restoring the IGF1R expression attenuated the function of miR-7 in GC cells; Finally analyses of miR-7 and IGF1R levels in human primary GC with matched lymph node metastasis tissue arrays revealed that miR-7 is inversely correlated with IGF1R expression metastasis gastric cancer hsa-miR-877-5p IGF1R 2.17859965442336 1.03593450648516e-07 -0.553106517250428 0.17432701125411 MirTarget -0.227979578170498 0.00082244186738806 NA NA NA hsa-miR-98-5p IGF1R 0.919961309193122 2.61963790596372e-05 -0.553106517250428 0.17432701125411 MirTarget -0.440398019671281 0.000811057715877079 NA NA NA hsa-miR-141-3p IGF2 1.45548825076434 0.00115958850961764 0.151877511512816 0.776679031065284 MirTarget;TargetScan -0.284042603011546 0.000670428796943855 NA NA NA hsa-miR-148a-3p IGF2 -1.53721533763578 3.55533747293117e-05 0.151877511512816 0.776679031065284 mirMAP -0.327741863348608 0.00106841626586743 NA NA NA hsa-miR-150-5p IGF2 0.147461377429675 0.753719621305461 0.151877511512816 0.776679031065284 miRNAWalker2_validate -0.388746964133376 9.6405774030514e-07 NA NA NA hsa-miR-200a-3p IGF2 0.717826667295984 0.193912116506827 0.151877511512816 0.776679031065284 MirTarget -0.188922908292284 0.0059568642254884 NA NA NA hsa-miR-34a-5p IGF2 0.794251341270032 0.00024017386701179 0.151877511512816 0.776679031065284 mirMAP -0.473058024257195 0.00742080783257377 NA NA NA hsa-miR-361-3p IGF2 -0.126462931388735 0.566052688733137 0.151877511512816 0.776679031065284 mirMAP -0.487392299771071 0.00566416916707517 NA NA NA hsa-miR-125a-3p IKBKB 1.19506542853853 0.00164364545717311 0.134870081917275 0.507473312093685 miRanda -0.128753900358831 0.000649508610645324 NA NA NA hsa-miR-543 IKBKB 0.0323775903217254 0.929458442755522 0.134870081917275 0.507473312093685 miRanda -0.128643682904471 0.00308168626813573 NA NA NA hsa-miR-125a-5p IKBKG -0.878090699011564 0.000213630844319685 0.482871701565075 0.00797160760932323 miRanda -0.235137534713953 1.20912221589607e-05 NA NA NA hsa-miR-148a-3p IKBKG -1.53721533763578 3.55533747293117e-05 0.482871701565075 0.00797160760932323 mirMAP -0.11630876600781 0.000633185783589711 NA NA NA hsa-miR-3065-3p IL2RA -1.03551124329864 0.0218397494946288 1.58636868885666 0.000898191400982656 MirTarget -0.304552754458665 4.86138250740433e-05 NA NA NA hsa-miR-375 IL2RA -2.94506033785642 0.00570147601654791 1.58636868885666 0.000898191400982656 miRanda -0.111470623759755 0.000438056598449831 NA NA NA hsa-miR-30b-3p IL2RB -0.266398938200332 0.400847813143994 1.38910197190606 0.000401856674821465 mirMAP -0.250810642439919 0.00526393068965205 NA NA NA hsa-miR-429 IL4R 1.40182602301928 0.00900426780286475 0.0040751665408143 0.986450236759292 miRNATAP -0.126339838670445 4.58833941906607e-05 NA NA NA hsa-miR-335-5p IL6 1.59953351087307 5.56170899867314e-05 -0.231605470294641 0.731469898867652 miRNAWalker2_validate -0.506635073744166 1.52521264215909e-05 NA NA NA hsa-miR-429 IL6 1.40182602301928 0.00900426780286475 -0.231605470294641 0.731469898867652 miRanda -0.444331362467888 2.80787806769216e-07 NA NA NA hsa-miR-106b-5p IL6R 1.70863907461894 2.04074794107142e-08 -0.905212913572453 0.00926947429038247 mirMAP -0.375064159148522 1.3455709733343e-06 NA NA NA hsa-miR-130b-3p IL6R 1.32714007211004 4.78676252285191e-05 -0.905212913572453 0.00926947429038247 mirMAP -0.252615757241476 0.000736777168802262 NA NA NA hsa-miR-135b-5p IL6R 4.09156383496059 1.32294295002438e-12 -0.905212913572453 0.00926947429038247 mirMAP -0.151344803673925 0.000164682685389657 NA NA NA hsa-miR-17-5p IL6R 1.65862087862483 8.45603406215941e-08 -0.905212913572453 0.00926947429038247 mirMAP -0.292216234222658 0.00016291526717577 NA NA NA hsa-miR-182-5p IL6R 0.887369486030646 0.0310640781418789 -0.905212913572453 0.00926947429038247 mirMAP -0.180178637117133 0.00276791054483128 NA NA NA hsa-miR-197-3p IL6R 0.888854270009261 0.000195183808214449 -0.905212913572453 0.00926947429038247 MirTarget -0.304801523529987 0.00340841643809556 NA NA NA hsa-miR-20a-5p IL6R 1.4503375861709 5.7813456424762e-07 -0.905212913572453 0.00926947429038247 mirMAP -0.277969071029928 0.000879001937726358 NA NA NA hsa-miR-320b IL6R 1.11183660885284 0.000497971211648503 -0.905212913572453 0.00926947429038247 miRanda;miRNATAP -0.26071612670564 0.000705010911972535 NA NA NA hsa-miR-320c IL6R 0.455072851945474 0.240613785444485 -0.905212913572453 0.00926947429038247 miRanda;miRNATAP -0.26551655079458 0.000337334599422536 NA NA NA hsa-miR-335-5p IL6R 1.59953351087307 5.56170899867314e-05 -0.905212913572453 0.00926947429038247 mirMAP -0.23527720833989 0.00011763154993372 NA NA NA hsa-miR-484 IL6R 0.71327898984355 0.00233605130771196 -0.905212913572453 0.00926947429038247 MirTarget -0.277530642524318 0.0094684399027223 NA NA NA hsa-miR-93-5p IL6R 1.7515174434778 1.59386482413883e-08 -0.905212913572453 0.00926947429038247 mirMAP -0.281989462839872 0.000258843056158441 NA NA NA hsa-miR-944 IL7 3.33123095809751 0.0177835044930391 0.773846525192666 0.0749239642197382 mirMAP -0.154079848373053 7.20062603683124e-10 NA NA NA hsa-miR-335-3p IL7R 2.5197689063267 2.20084506976733e-09 0.504021298531021 0.285852618610604 mirMAP -0.24291413782531 0.00142773183477774 NA NA NA hsa-let-7a-3p INSR 0.503048155002889 0.0411145454335299 -0.610545747718975 0.0384245633208452 mirMAP -0.410311347775898 1.18425170189008e-06 NA NA NA hsa-let-7b-3p INSR 0.21838629112113 0.296038413622566 -0.610545747718975 0.0384245633208452 mirMAP -0.369834307028296 0.000291538029966231 NA NA NA hsa-let-7b-5p INSR 0.0582902155815681 0.781400138984745 -0.610545747718975 0.0384245633208452 miRNATAP -0.526549443920689 1.31398968291732e-07 NA NA NA hsa-miR-127-5p INSR 0.684144175589776 0.021634535736883 -0.610545747718975 0.0384245633208452 PITA -0.330819457908089 1.85622777870309e-06 NA NA NA hsa-miR-15b-3p INSR 1.75738933306437 3.00554466232543e-08 -0.610545747718975 0.0384245633208452 mirMAP -0.221503872117918 0.000522115172240783 NA NA NA hsa-miR-205-5p INSR 3.13520672931882 0.0293226471971167 -0.610545747718975 0.0384245633208452 mirMAP -0.131303947182585 2.09940673475484e-24 NA NA NA hsa-miR-27a-3p INSR 1.29886998470345 2.68986118553486e-08 -0.610545747718975 0.0384245633208452 miRNATAP -0.618262769375196 8.16350445855504e-14 NA NA NA hsa-miR-27b-3p INSR 0.0836323965901755 0.725273923274 -0.610545747718975 0.0384245633208452 miRNATAP -0.466805472556421 9.42259622619392e-08 NA NA NA hsa-miR-539-5p INSR -0.189590870053519 0.584280352847564 -0.610545747718975 0.0384245633208452 mirMAP -0.16609214047185 0.00677848187570433 NA NA NA hsa-miR-128-3p IRS1 0.98280381420517 5.77641850797209e-05 -0.302307407532571 0.334728792553483 MirTarget -0.301837553095963 0.000813538559891091 26352220 In addition insulin receptor substrate 1 IRS1 a key mediator in oncogenic insulin-like growth factor IGF signaling was confirmed as a direct target of miR-128 by a luciferase reporter assay; Western blot analysis indicated that the overexpression of miR-128 significantly downregulated IRS1 expression and its downstream Akt signaling in CRC cells; Moreover miR-128 was negatively associated with IRS1 in CRC tissues compared to adjacent non-tumor tissues; Taken together these data suggested that miR-128 serves as a tumor suppressor and blocks CRC growth and metastasis by targeting IRS1 metastasis colorectal cancer hsa-miR-142-5p IRS1 1.55592486377018 6.69269968016779e-06 -0.302307407532571 0.334728792553483 MirTarget;PITA -0.191945835488044 0.00230307484569463 NA NA NA hsa-miR-148a-3p IRS1 -1.53721533763578 3.55533747293117e-05 -0.302307407532571 0.334728792553483 miRNAWalker2_validate;miRTarBase -0.169333470058119 0.00395238140945378 NA NA NA hsa-miR-16-1-3p IRS1 1.43227522002564 3.70920454953168e-08 -0.302307407532571 0.334728792553483 MirTarget -0.326358817775924 7.59033793748282e-05 NA NA NA hsa-miR-17-3p IRS1 1.31126744284937 3.24768335024185e-07 -0.302307407532571 0.334728792553483 MirTarget -0.300151885591675 0.000377726528474908 NA NA NA hsa-miR-200b-3p IRS1 0.974577911407732 0.0595020056914543 -0.302307407532571 0.334728792553483 TargetScan -0.126124043256344 0.00319564298754274 26314828 Taken together our results suggest that miR-200 may activate AKT in lung adenocarcinoma cells through a FOG2-independent mechanism involving IRS-1 lung cancer hsa-miR-200c-3p IRS1 1.28185685499076 0.00369777635539177 -0.302307407532571 0.334728792553483 miRNATAP -0.134862138547114 0.00694907212441206 NA NA NA hsa-miR-30d-5p IRS1 -0.5492586056147 0.0140125082460125 -0.302307407532571 0.334728792553483 MirTarget;miRNATAP -0.331387968444456 0.0009519921464991 NA NA NA hsa-miR-335-3p IRS1 2.5197689063267 2.20084506976733e-09 -0.302307407532571 0.334728792553483 MirTarget -0.161280712379704 0.00138801242284095 NA NA NA hsa-miR-429 IRS1 1.40182602301928 0.00900426780286475 -0.302307407532571 0.334728792553483 miRanda;miRNATAP -0.125665702942416 0.00217672302329799 NA NA NA hsa-miR-660-5p IRS1 -0.0206552819434673 0.938868734063643 -0.302307407532571 0.334728792553483 MirTarget;miRNATAP -0.245117654851103 0.00333866923711234 NA NA NA hsa-miR-141-5p ITGA1 2.07543489990205 6.42575039070838e-06 -0.620484139376128 0.0903638382561566 MirTarget -0.23295845355935 2.00008567001798e-05 NA NA NA hsa-miR-200c-3p ITGA1 1.28185685499076 0.00369777635539177 -0.620484139376128 0.0903638382561566 MirTarget -0.27270971975229 2.08516803993402e-06 NA NA NA hsa-miR-3065-5p ITGA1 -0.241623656423063 0.633116553078159 -0.620484139376128 0.0903638382561566 MirTarget -0.219995565470546 2.49277140001113e-05 NA NA NA hsa-miR-32-3p ITGA1 0.583525764322974 0.11837203008551 -0.620484139376128 0.0903638382561566 mirMAP -0.239372446157893 0.00231644692754049 NA NA NA hsa-miR-320b ITGA1 1.11183660885284 0.000497971211648503 -0.620484139376128 0.0903638382561566 miRanda -0.270080136401848 0.000817216724178595 NA NA NA hsa-miR-330-3p ITGA1 0.798460296022179 0.00746538156533435 -0.620484139376128 0.0903638382561566 mirMAP -0.262948973232955 0.00258805463882666 NA NA NA hsa-miR-335-3p ITGA1 2.5197689063267 2.20084506976733e-09 -0.620484139376128 0.0903638382561566 mirMAP -0.170968591878983 0.0039495685426104 NA NA NA hsa-miR-335-5p ITGA1 1.59953351087307 5.56170899867314e-05 -0.620484139376128 0.0903638382561566 miRNAWalker2_validate -0.190387180053094 0.00318032354994612 NA NA NA hsa-miR-361-5p ITGA1 0.407725414130987 0.0181260969156347 -0.620484139376128 0.0903638382561566 miRanda -0.480600297448237 0.00197763397160854 NA NA NA hsa-miR-429 ITGA1 1.40182602301928 0.00900426780286475 -0.620484139376128 0.0903638382561566 MirTarget;miRanda -0.145983830408631 0.00240806882532618 NA NA NA hsa-miR-452-5p ITGA1 2.08756506185889 0.000258095769002813 -0.620484139376128 0.0903638382561566 mirMAP -0.240811987491889 3.32476620884281e-08 NA NA NA hsa-miR-576-5p ITGA1 0.625714137488957 0.0417100301848969 -0.620484139376128 0.0903638382561566 mirMAP -0.272775194169875 0.00131452598962444 NA NA NA hsa-miR-590-3p ITGA1 1.11654983899947 0.000160782154924864 -0.620484139376128 0.0903638382561566 miRanda;mirMAP -0.337763568336748 9.55778469608867e-05 NA NA NA hsa-miR-590-5p ITGA1 1.04171442093217 0.000272475544954865 -0.620484139376128 0.0903638382561566 miRanda;mirMAP -0.359707124128715 5.95283987812874e-05 NA NA NA hsa-miR-944 ITGA1 3.33123095809751 0.0177835044930391 -0.620484139376128 0.0903638382561566 mirMAP -0.124988008802426 3.39745526696867e-09 NA NA NA hsa-let-7g-3p ITGA10 0.64979533805273 0.0103084600883006 -1.5611050138095 4.27274941286422e-05 MirTarget;miRNATAP -0.392422580680152 0.000322415299678124 NA NA NA hsa-miR-15a-5p ITGA10 1.03783090449383 7.40334108980898e-07 -1.5611050138095 4.27274941286422e-05 MirTarget -0.353560648670528 0.00687861104038161 NA NA NA hsa-miR-15b-5p ITGA10 1.62046407540723 5.42152621571078e-09 -1.5611050138095 4.27274941286422e-05 MirTarget -0.5410874323104 6.56281258593328e-09 NA NA NA hsa-miR-16-5p ITGA10 1.00515772948091 5.33912942007619e-06 -1.5611050138095 4.27274941286422e-05 MirTarget -0.619087373617987 3.49986224849073e-07 NA NA NA hsa-miR-320b ITGA10 1.11183660885284 0.000497971211648503 -1.5611050138095 4.27274941286422e-05 miRanda -0.259940850116579 0.00243745273693834 NA NA NA hsa-miR-324-5p ITGA10 1.08820215809537 3.11674414561836e-05 -1.5611050138095 4.27274941286422e-05 miRanda;miRNATAP -0.464576559604397 6.76745689906171e-06 NA NA NA hsa-miR-424-5p ITGA10 1.08509868581983 0.000420473853818268 -1.5611050138095 4.27274941286422e-05 MirTarget -0.318902735249274 0.000320166688689498 NA NA NA hsa-miR-484 ITGA10 0.71327898984355 0.00233605130771196 -1.5611050138095 4.27274941286422e-05 miRNATAP -0.364005586155916 0.0021141246841324 NA NA NA hsa-miR-708-5p ITGA10 1.41830449251856 0.0109647946476309 -1.5611050138095 4.27274941286422e-05 MirTarget -0.207418541577884 1.91672158585083e-05 NA NA NA hsa-miR-940 ITGA10 1.64406174271686 0.000690854900107004 -1.5611050138095 4.27274941286422e-05 MirTarget;miRNATAP -0.40030084498355 4.11656477827233e-10 NA NA NA hsa-miR-29a-3p ITGA11 -0.113012156986374 0.615005009685815 1.01194740172798 0.0620777830723862 miRNAWalker2_validate;miRTarBase -0.602004043408278 0.000568146591490732 NA NA NA hsa-miR-429 ITGA11 1.40182602301928 0.00900426780286475 1.01194740172798 0.0620777830723862 miRNATAP -0.222610713784901 0.00179643990533417 NA NA NA hsa-miR-139-5p ITGA2 -1.83374360776637 1.22019901002824e-09 1.82303263479838 1.19675255377204e-07 PITA;miRanda -0.309707147623095 0.000108371369022976 NA NA NA hsa-miR-186-5p ITGA2 0.149964130725901 0.434709542998771 1.82303263479838 1.19675255377204e-07 mirMAP -0.43824839759812 0.00118132940169133 NA NA NA hsa-miR-26a-5p ITGA2 -0.384110714440647 0.0442498636014044 1.82303263479838 1.19675255377204e-07 mirMAP -0.537438189144858 6.31005898652249e-05 NA NA NA hsa-miR-26b-5p ITGA2 -0.301646326928219 0.160081421968103 1.82303263479838 1.19675255377204e-07 mirMAP -0.343995930734224 0.00419056050956817 NA NA NA hsa-miR-30d-5p ITGA2 -0.5492586056147 0.0140125082460125 1.82303263479838 1.19675255377204e-07 mirMAP -0.396563759470854 0.000501652353664741 NA NA NA hsa-miR-30e-5p ITGA2 -0.573784818166736 0.0112497802572927 1.82303263479838 1.19675255377204e-07 mirMAP -0.345967862419713 0.00216432091547215 NA NA NA hsa-miR-326 ITGA2 -0.429748586406214 0.2629894124021 1.82303263479838 1.19675255377204e-07 PITA -0.272070154422955 3.78635264079111e-05 NA NA NA hsa-miR-532-5p ITGA2 0.313080805824184 0.252248939356301 1.82303263479838 1.19675255377204e-07 MirTarget -0.315619723498482 0.000695566967204546 NA NA NA hsa-miR-664a-3p ITGA2 -0.83041219170254 0.000136267547251167 1.82303263479838 1.19675255377204e-07 MirTarget;mirMAP -0.327339548650456 0.00496212045433972 NA NA NA hsa-miR-129-5p ITGA3 -2.56914016541176 2.36237896095709e-06 0.976842540009825 0.00522336644012101 MirTarget -0.206618201566168 3.98119342370606e-06 NA NA NA hsa-miR-139-5p ITGA3 -1.83374360776637 1.22019901002824e-09 0.976842540009825 0.00522336644012101 PITA;miRanda -0.258041165709297 0.00119850030639378 NA NA NA hsa-miR-181c-5p ITGA3 0.336826967681288 0.112932307913601 0.976842540009825 0.00522336644012101 miRNATAP -0.436775604243993 0.000252892741396774 NA NA NA hsa-miR-186-5p ITGA3 0.149964130725901 0.434709542998771 0.976842540009825 0.00522336644012101 miRNATAP -0.407712663042699 0.00234203827917381 NA NA NA hsa-miR-28-5p ITGA3 -0.238617853755144 0.167318538669818 0.976842540009825 0.00522336644012101 miRanda -0.456079642912358 0.00232634478814667 NA NA NA hsa-miR-326 ITGA3 -0.429748586406214 0.2629894124021 0.976842540009825 0.00522336644012101 miRanda -0.197732434779854 0.00275525430005407 NA NA NA hsa-miR-107 ITGA5 0.904627575346218 4.67936495073904e-05 -0.487036121002453 0.168143952645478 PITA;miRanda -0.547256073168904 7.34941460918876e-07 NA NA NA hsa-miR-148a-3p ITGA5 -1.53721533763578 3.55533747293117e-05 -0.487036121002453 0.168143952645478 miRNATAP -0.270995317010704 3.65184248195192e-05 NA NA NA hsa-miR-148b-3p ITGA5 0.295175884456199 0.17466422420702 -0.487036121002453 0.168143952645478 miRNAWalker2_validate -0.481857193369477 3.45374965877632e-05 27328731 Notably transendothelial migration in vitro and extravasation in vivo impaired by singly alternating miR-214 or miR-148b could be overridden by overexpression of ITGA5 or ALCAM in the same tumor cells melanoma hsa-miR-183-5p ITGA5 1.65900927871187 0.000522025364980187 -0.487036121002453 0.168143952645478 miRNAWalker2_validate -0.164697749010525 0.00142809885400767 NA NA NA hsa-miR-194-3p ITGA5 0.259420201261466 0.821811295418686 -0.487036121002453 0.168143952645478 miRNATAP -0.122302090520396 9.16447145833413e-09 NA NA NA hsa-miR-25-3p ITGA5 1.00604871526544 0.000421838061147906 -0.487036121002453 0.168143952645478 miRNATAP -0.298318780537736 0.000618520918566734 NA NA NA hsa-miR-3065-3p ITGA5 -1.03551124329864 0.0218397494946288 -0.487036121002453 0.168143952645478 miRNATAP -0.176477705190929 0.00138765322111752 NA NA NA hsa-miR-30d-5p ITGA5 -0.5492586056147 0.0140125082460125 -0.487036121002453 0.168143952645478 miRNATAP -0.649219190546994 3.47116862319541e-09 NA NA NA hsa-miR-32-5p ITGA5 0.415247682945382 0.106458022460373 -0.487036121002453 0.168143952645478 miRNATAP -0.430320623699758 9.64102677167465e-06 NA NA NA hsa-miR-338-3p ITGA5 -0.959276231066179 0.0191473351014091 -0.487036121002453 0.168143952645478 miRanda -0.209832094067179 0.000557641939996973 NA NA NA hsa-miR-429 ITGA5 1.40182602301928 0.00900426780286475 -0.487036121002453 0.168143952645478 miRNATAP -0.290422350034528 6.09520099281734e-11 NA NA NA hsa-miR-629-3p ITGA5 1.40326397107309 9.7803063526732e-05 -0.487036121002453 0.168143952645478 miRNATAP -0.18625091062054 0.00679666927479237 NA NA NA hsa-miR-92a-3p ITGA5 1.2209325870225 6.8757197708107e-06 -0.487036121002453 0.168143952645478 miRNAWalker2_validate;miRTarBase;miRNATAP -0.399640081564293 8.72886817989696e-06 23499550 The level of miR-92a expression was significantly inversely correlated with ITGA5 expression in various cancer cells; miR-92a overexpression reduced the luciferase activity of the ITGA5 3'-untranslated region suggesting that ITGA5 mRNA is a direct target of miR-92a ovarian cancer hsa-miR-98-5p ITGA5 0.919961309193122 2.61963790596372e-05 -0.487036121002453 0.168143952645478 miRNAWalker2_validate -0.331296165506695 0.00380830552251342 NA NA NA hsa-miR-217 ITGA6 -0.0121404731225336 0.980818372851502 0.89254240289864 0.00953770879380337 miRanda -0.153759285209905 0.00158337629120998 NA NA NA hsa-miR-330-5p ITGA7 0.488365986827708 0.0512207630808233 -1.88793295149324 9.50031857111008e-06 miRanda -0.447671391304575 0.000316428702318574 NA NA NA hsa-miR-339-5p ITGA7 0.770566566962108 0.00816529093411862 -1.88793295149324 9.50031857111008e-06 miRanda -0.463772350269823 1.0076186793498e-05 NA NA NA hsa-miR-34c-3p ITGA7 2.25273698056457 9.06191072601281e-05 -1.88793295149324 9.50031857111008e-06 miRNATAP -0.219407886229268 3.38350603879816e-05 NA NA NA hsa-miR-615-3p ITGA7 2.82967143704683 3.05118423223543e-05 -1.88793295149324 9.50031857111008e-06 miRNAWalker2_validate -0.241660317740319 8.71313948673434e-05 NA NA NA hsa-miR-130b-3p ITGA8 1.32714007211004 4.78676252285191e-05 -4.03791429301129 1.95765364555316e-07 mirMAP -1.14350842316512 2.82974133201854e-12 NA NA NA hsa-miR-144-3p ITGA8 -0.13309578176575 0.798245647923351 -4.03791429301129 1.95765364555316e-07 mirMAP -0.376986167681209 0.000631849882949002 NA NA NA hsa-miR-16-1-3p ITGA8 1.43227522002564 3.70920454953168e-08 -4.03791429301129 1.95765364555316e-07 mirMAP -0.985572875318876 2.67605111538543e-06 NA NA NA hsa-miR-183-5p ITGA8 1.65900927871187 0.000522025364980187 -4.03791429301129 1.95765364555316e-07 miRNAWalker2_validate -0.821672521097329 1.25807633399131e-13 NA NA NA hsa-miR-19b-1-5p ITGA8 1.38738648038895 1.3113681938066e-06 -4.03791429301129 1.95765364555316e-07 mirMAP -0.928899040106793 1.19209086496863e-06 NA NA NA hsa-miR-21-5p ITGA8 1.75445050487988 2.41825549682022e-23 -4.03791429301129 1.95765364555316e-07 mirMAP -1.47547929021229 3.01271217880737e-07 NA NA NA hsa-miR-301a-3p ITGA8 1.44721900431161 6.35068481036652e-06 -4.03791429301129 1.95765364555316e-07 mirMAP -0.850363613037998 6.61510950287717e-07 NA NA NA hsa-miR-32-3p ITGA8 0.583525764322974 0.11837203008551 -4.03791429301129 1.95765364555316e-07 mirMAP -0.49349848215399 0.00414907368671476 NA NA NA hsa-miR-335-3p ITGA8 2.5197689063267 2.20084506976733e-09 -4.03791429301129 1.95765364555316e-07 mirMAP -0.546159634207721 2.02804796349274e-05 NA NA NA hsa-miR-33a-5p ITGA8 0.407757858040717 0.321429014317207 -4.03791429301129 1.95765364555316e-07 mirMAP -0.929574795107531 1.78511735870086e-12 NA NA NA hsa-miR-590-5p ITGA8 1.04171442093217 0.000272475544954865 -4.03791429301129 1.95765364555316e-07 mirMAP -1.29154091363034 7.38721791873806e-12 NA NA NA hsa-miR-615-3p ITGA8 2.82967143704683 3.05118423223543e-05 -4.03791429301129 1.95765364555316e-07 miRNAWalker2_validate -0.462933891461079 4.24797900286605e-05 NA NA NA hsa-miR-944 ITGA8 3.33123095809751 0.0177835044930391 -4.03791429301129 1.95765364555316e-07 mirMAP -0.262368305088099 1.60663013835066e-08 NA NA NA hsa-miR-103a-2-5p ITGA9 0.808041560899298 0.019989162317947 -2.67016627412918 1.75559615318552e-06 mirMAP -0.361352333926184 0.00211444305183285 NA NA NA hsa-miR-141-5p ITGA9 2.07543489990205 6.42575039070838e-06 -2.67016627412918 1.75559615318552e-06 MirTarget -0.399711466686921 2.65277887522431e-06 NA NA NA hsa-miR-200b-3p ITGA9 0.974577911407732 0.0595020056914543 -2.67016627412918 1.75559615318552e-06 mirMAP -0.241849258045966 0.00206416519206213 26334393;24518294 We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness;β1 integrin inhibition elicits a prometastatic switch through the TGFβ miR 200 ZEB network in E cadherin positive triple negative breast cancer ; esophageal cancer;breast cancer hsa-miR-20a-3p ITGA9 1.13957127410163 0.000451087640268489 -2.67016627412918 1.75559615318552e-06 mirMAP -0.647692862507589 9.65291523831323e-08 NA NA NA hsa-miR-3065-5p ITGA9 -0.241623656423063 0.633116553078159 -2.67016627412918 1.75559615318552e-06 mirMAP -0.331673527912059 5.09222875570085e-05 NA NA NA hsa-miR-324-5p ITGA9 1.08820215809537 3.11674414561836e-05 -2.67016627412918 1.75559615318552e-06 miRanda -0.531327796436289 0.00056641984852364 NA NA NA hsa-miR-330-3p ITGA9 0.798460296022179 0.00746538156533435 -2.67016627412918 1.75559615318552e-06 mirMAP -0.40331133537838 0.00318289579506501 NA NA NA hsa-miR-33a-3p ITGA9 0.347011402017138 0.321709379745392 -2.67016627412918 1.75559615318552e-06 mirMAP -0.43078712196903 0.000443432017888747 NA NA NA hsa-miR-33a-5p ITGA9 0.407757858040717 0.321429014317207 -2.67016627412918 1.75559615318552e-06 mirMAP -0.602574307824506 2.85445740033983e-10 NA NA NA hsa-miR-33b-5p ITGA9 0.267227362818466 0.614814331176942 -2.67016627412918 1.75559615318552e-06 mirMAP -0.349227194394546 0.000423826659110242 NA NA NA hsa-miR-34c-3p ITGA9 2.25273698056457 9.06191072601281e-05 -2.67016627412918 1.75559615318552e-06 mirMAP -0.237234839736153 0.000725271898621371 NA NA NA hsa-miR-429 ITGA9 1.40182602301928 0.00900426780286475 -2.67016627412918 1.75559615318552e-06 miRanda -0.29828421050222 6.49579060565084e-05 NA NA NA hsa-miR-452-3p ITGA9 2.2028815467959 0.00185370432491004 -2.67016627412918 1.75559615318552e-06 MirTarget -0.29739228200656 2.49029372157434e-06 NA NA NA hsa-miR-452-5p ITGA9 2.08756506185889 0.000258095769002813 -2.67016627412918 1.75559615318552e-06 mirMAP -0.265708311868273 0.000137056574437592 NA NA NA hsa-miR-484 ITGA9 0.71327898984355 0.00233605130771196 -2.67016627412918 1.75559615318552e-06 miRNAWalker2_validate -0.660439492690821 0.000145136783870347 NA NA NA hsa-miR-576-5p ITGA9 0.625714137488957 0.0417100301848969 -2.67016627412918 1.75559615318552e-06 mirMAP -0.382894436552499 0.00407669879374943 NA NA NA hsa-miR-589-3p ITGA9 1.01962606923682 0.00577853347252709 -2.67016627412918 1.75559615318552e-06 mirMAP -0.310542912659825 0.00475752484544297 NA NA NA hsa-miR-590-3p ITGA9 1.11654983899947 0.000160782154924864 -2.67016627412918 1.75559615318552e-06 miRanda -0.586475107864006 1.38408264718798e-05 NA NA NA hsa-miR-590-5p ITGA9 1.04171442093217 0.000272475544954865 -2.67016627412918 1.75559615318552e-06 miRanda -0.79927911836973 5.6366161746693e-09 NA NA NA hsa-miR-877-5p ITGA9 2.17859965442336 1.03593450648516e-07 -2.67016627412918 1.75559615318552e-06 mirMAP -0.352742661865146 0.00023254108042711 NA NA NA hsa-miR-142-5p ITGAV 1.55592486377018 6.69269968016779e-06 0.170268869737817 0.518461433463577 MirTarget;PITA -0.149664657944716 0.0047233679986809 NA NA NA hsa-miR-186-5p ITGAV 0.149964130725901 0.434709542998771 0.170268869737817 0.518461433463577 mirMAP -0.412772542950313 2.95667974546309e-05 NA NA NA hsa-miR-25-3p ITGAV 1.00604871526544 0.000421838061147906 0.170268869737817 0.518461433463577 MirTarget;miRNATAP -0.199585868141085 0.00212481951830816 NA NA NA hsa-miR-30e-3p ITGAV -0.913131357083321 7.29096855615228e-06 0.170268869737817 0.518461433463577 mirMAP -0.308240881161943 0.000721691871802401 NA NA NA hsa-miR-32-5p ITGAV 0.415247682945382 0.106458022460373 0.170268869737817 0.518461433463577 miRNAWalker2_validate;MirTarget;miRNATAP -0.38747888094873 5.69126067817527e-08 NA NA NA hsa-miR-335-3p ITGAV 2.5197689063267 2.20084506976733e-09 0.170268869737817 0.518461433463577 MirTarget -0.191449056625224 4.60407294826616e-06 NA NA NA hsa-miR-33a-3p ITGAV 0.347011402017138 0.321709379745392 0.170268869737817 0.518461433463577 MirTarget -0.206373384664145 0.000226962001191522 NA NA NA hsa-miR-361-5p ITGAV 0.407725414130987 0.0181260969156347 0.170268869737817 0.518461433463577 MirTarget;miRanda -0.371270186156443 0.000822530289446712 NA NA NA hsa-miR-3928-3p ITGAV 1.3021682800308 0.00117241057113773 0.170268869737817 0.518461433463577 MirTarget -0.137920756885535 0.00982481953528062 NA NA NA hsa-miR-429 ITGAV 1.40182602301928 0.00900426780286475 0.170268869737817 0.518461433463577 miRanda -0.127573914161302 0.000194044828831387 NA NA NA hsa-miR-550a-3p ITGAV 2.05849884025997 7.99642185793604e-07 0.170268869737817 0.518461433463577 miRNATAP -0.126821324866793 0.00856356429216092 NA NA NA hsa-miR-577 ITGAV 0.911619788986754 0.2256062124148 0.170268869737817 0.518461433463577 mirMAP -0.118825771133592 1.77086835093214e-06 NA NA NA hsa-miR-590-3p ITGAV 1.11654983899947 0.000160782154924864 0.170268869737817 0.518461433463577 MirTarget;PITA;miRanda -0.173578919934922 0.00554299178876213 NA NA NA hsa-miR-7-1-3p ITGAV 0.709309110750947 0.0412301737463194 0.170268869737817 0.518461433463577 mirMAP -0.229806356496395 1.46149451924112e-05 NA NA NA hsa-miR-92a-3p ITGAV 1.2209325870225 6.8757197708107e-06 0.170268869737817 0.518461433463577 MirTarget;miRNATAP -0.225670476956276 0.000835317304585331 NA NA NA hsa-miR-139-5p ITGB1 -1.83374360776637 1.22019901002824e-09 0.267016763315638 0.217071042534738 miRanda -0.166330921446088 0.000621163759489789 NA NA NA hsa-miR-140-3p ITGB1 -0.296251775392129 0.127539826012144 0.267016763315638 0.217071042534738 PITA -0.265561587473128 0.000960278584559249 NA NA NA hsa-miR-29c-3p ITGB1 -1.62454036584589 5.38376515586029e-07 0.267016763315638 0.217071042534738 MirTarget;miRNATAP -0.177825861358882 9.78724055745933e-05 26766915 MiR 29c inhibits cell growth invasion and migration of pancreatic cancer by targeting ITGB1; Further analysis revealed that ITGB1 is one of the functional target genes of miR-29c and knockdown of ITGB1 inhibited the proliferation migration and invasion of PC cells which was similar to the effects of overexpression of miR-29c pancreatic cancer hsa-miR-769-5p ITGB1 1.14821899306381 1.27143750879772e-06 0.267016763315638 0.217071042534738 miRNAWalker2_validate -0.223517510859641 0.000419403649676611 NA NA NA hsa-let-7b-5p ITGB3 0.0582902155815681 0.781400138984745 -1.40916296337126 0.002071079307225 MirTarget;miRNATAP -0.743990749776556 2.23051840233951e-06 NA NA NA hsa-let-7d-5p ITGB3 0.981733854788227 7.26366577706469e-07 -1.40916296337126 0.002071079307225 MirTarget -0.587007460934112 0.000341791924889036 NA NA NA hsa-miR-185-5p ITGB3 1.14351510556643 1.07346945085714e-08 -1.40916296337126 0.002071079307225 MirTarget -0.700312513320449 1.10039932237541e-05 NA NA NA hsa-miR-18a-3p ITGB3 2.35188582849667 1.39401350286321e-08 -1.40916296337126 0.002071079307225 miRNATAP -0.265286573052279 0.000494514813724871 NA NA NA hsa-miR-221-3p ITGB3 1.33496247538338 3.82022531235275e-07 -1.40916296337126 0.002071079307225 MirTarget -0.56863386913382 2.28894169763649e-06 NA NA NA hsa-miR-222-3p ITGB3 1.39382731585819 9.98182478024671e-07 -1.40916296337126 0.002071079307225 MirTarget -0.494364537134536 9.0708405241597e-06 NA NA NA hsa-miR-320b ITGB3 1.11183660885284 0.000497971211648503 -1.40916296337126 0.002071079307225 miRanda -0.263575919369573 0.00998810655827514 NA NA NA hsa-miR-429 ITGB3 1.40182602301928 0.00900426780286475 -1.40916296337126 0.002071079307225 miRanda -0.228312520495241 0.000150308985352788 NA NA NA hsa-miR-590-3p ITGB3 1.11654983899947 0.000160782154924864 -1.40916296337126 0.002071079307225 PITA;miRanda -0.450666556081107 3.46805032242963e-05 NA NA NA hsa-miR-590-5p ITGB3 1.04171442093217 0.000272475544954865 -1.40916296337126 0.002071079307225 miRanda -0.508383401728035 5.98305702298863e-06 NA NA NA hsa-miR-98-5p ITGB3 0.919961309193122 2.61963790596372e-05 -1.40916296337126 0.002071079307225 miRNAWalker2_validate;MirTarget -0.457185622064576 0.00224967508049455 26445551 miR 98 targets ITGB3 to inhibit proliferation migration and invasion of non small cell lung cancer; Furthermore we identified that miR-98 exerted inhibitory roles by directly binding to 3'-UTR of ITGB3 mRNA thus negatively regulated the expression of ITGB3; Interestingly upon restoring the expression of ITGB3 the effect of miR-98 on cell proliferation was partially reversed; Our findings suggest that miR-98 prevents proliferation migration and invasion of lung cancer cells by directly binding to the 3'-UTR of ITGB3 mRNA and could be a promising treatment option in anticancer therapy lung squamous cell cancer hsa-miR-30a-5p ITGB4 -1.71922855140016 3.20574349285256e-07 1.41588799374199 9.61883971034951e-05 miRNAWalker2_validate -0.220866037740422 0.00362923047276444 NA NA NA hsa-miR-532-5p ITGB4 0.313080805824184 0.252248939356301 1.41588799374199 9.61883971034951e-05 miRNATAP -0.391548530397807 4.46659405912693e-05 NA NA NA hsa-miR-139-5p ITGB5 -1.83374360776637 1.22019901002824e-09 0.313873412412446 0.162052688227069 miRanda -0.157368931086176 0.00187918850416451 NA NA NA hsa-miR-155-5p ITGB5 1.28707757465885 8.6344688246758e-05 0.313873412412446 0.162052688227069 miRNAWalker2_validate -0.180355285878726 0.000146344857093698 NA NA NA hsa-miR-335-5p ITGB5 1.59953351087307 5.56170899867314e-05 0.313873412412446 0.162052688227069 miRNAWalker2_validate -0.103075395159209 0.00897412138238449 NA NA NA hsa-miR-378a-5p ITGB5 -0.557166502179376 0.0344581590006454 0.313873412412446 0.162052688227069 MirTarget -0.246369089955341 4.16226627825094e-05 NA NA NA hsa-miR-484 ITGB5 0.71327898984355 0.00233605130771196 0.313873412412446 0.162052688227069 miRNATAP -0.189734806183083 0.00544690869017285 NA NA NA hsa-miR-139-5p ITGB8 -1.83374360776637 1.22019901002824e-09 1.47570088906486 0.00017027951047292 PITA;miRanda;miRNATAP -0.252328984942025 0.00529626350239183 NA NA NA hsa-miR-148a-3p ITGB8 -1.53721533763578 3.55533747293117e-05 1.47570088906486 0.00017027951047292 miRNATAP -0.372157169138344 3.79543150627376e-07 NA NA NA hsa-miR-26a-5p ITGB8 -0.384110714440647 0.0442498636014044 1.47570088906486 0.00017027951047292 MirTarget -0.633474778181817 2.46590497829527e-05 NA NA NA hsa-miR-26b-5p ITGB8 -0.301646326928219 0.160081421968103 1.47570088906486 0.00017027951047292 MirTarget -0.470418587431697 0.000443019609280114 NA NA NA hsa-miR-32-3p ITGB8 0.583525764322974 0.11837203008551 1.47570088906486 0.00017027951047292 MirTarget -0.226040206978413 0.0083394629935804 NA NA NA hsa-miR-326 ITGB8 -0.429748586406214 0.2629894124021 1.47570088906486 0.00017027951047292 MirTarget;miRanda;miRNATAP -0.322500515185462 1.24221560514053e-05 NA NA NA hsa-miR-335-5p ITGB8 1.59953351087307 5.56170899867314e-05 1.47570088906486 0.00017027951047292 miRNAWalker2_validate -0.242741042014224 0.000512282708106473 NA NA NA hsa-miR-338-3p ITGB8 -0.959276231066179 0.0191473351014091 1.47570088906486 0.00017027951047292 miRanda -0.323190474030463 1.79335154834532e-06 NA NA NA hsa-miR-532-5p ITGB8 0.313080805824184 0.252248939356301 1.47570088906486 0.00017027951047292 PITA -0.587498854165427 6.88003388905935e-09 NA NA NA hsa-miR-577 ITGB8 0.911619788986754 0.2256062124148 1.47570088906486 0.00017027951047292 MirTarget;PITA -0.199242954558479 1.08596035599818e-07 NA NA NA hsa-miR-106a-5p JAK1 -0.173255688252641 0.642872703263671 -0.136842202385446 0.389827921807066 MirTarget -0.101846610542039 0.000666717753075567 NA NA NA hsa-miR-106b-5p JAK1 1.70863907461894 2.04074794107142e-08 -0.136842202385446 0.389827921807066 miRNAWalker2_validate;MirTarget -0.110290079275673 0.00189679247366163 NA NA NA hsa-miR-128-3p JAK1 0.98280381420517 5.77641850797209e-05 -0.136842202385446 0.389827921807066 miRNAWalker2_validate -0.167478175907375 0.000212094943900306 NA NA NA hsa-miR-15b-5p JAK1 1.62046407540723 5.42152621571078e-09 -0.136842202385446 0.389827921807066 miRNAWalker2_validate -0.190253406445669 6.18524170361677e-07 NA NA NA hsa-miR-17-5p JAK1 1.65862087862483 8.45603406215941e-08 -0.136842202385446 0.389827921807066 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.117925701047491 0.000746095407405163 NA NA NA hsa-miR-23b-3p JAK1 -0.286465516491361 0.18664668472995 -0.136842202385446 0.389827921807066 miRNAWalker2_validate -0.174239660889248 0.000877182003816596 NA NA NA hsa-miR-93-5p JAK1 1.7515174434778 1.59386482413883e-08 -0.136842202385446 0.389827921807066 MirTarget;miRNATAP -0.119943568360841 0.000560781167464368 NA NA NA hsa-let-7a-3p JAK2 0.503048155002889 0.0411145454335299 -0.411963460232815 0.202983998863373 mirMAP;miRNATAP -0.317263862892994 0.000724186448180031 NA NA NA hsa-miR-337-3p JAK2 -0.722905798364932 0.0337389336330079 -0.411963460232815 0.202983998863373 PITA -0.251148982975929 0.00017817914602114 NA NA NA hsa-miR-3065-5p JAK3 -0.241623656423063 0.633116553078159 0.536999198640745 0.127187071032972 MirTarget;mirMAP -0.205432454309017 4.22150056081198e-05 NA NA NA hsa-miR-149-5p KDR 0.706277554734069 0.296848731347677 -0.700906973648848 0.0493591792780238 miRNATAP -0.219672189869555 1.13049786050969e-09 NA NA NA hsa-miR-23a-3p KDR 1.10685926969665 3.16223452471768e-08 -0.700906973648848 0.0493591792780238 mirMAP -0.553407435563254 7.15413862125e-06 NA NA NA hsa-let-7a-3p KIT 0.503048155002889 0.0411145454335299 -3.33532221246538 5.36354430486114e-10 mirMAP -0.457611683794333 0.0053658743402956 NA NA NA hsa-let-7b-3p KIT 0.21838629112113 0.296038413622566 -3.33532221246538 5.36354430486114e-10 mirMAP -0.599934919122108 0.00216223528866986 NA NA NA hsa-let-7f-1-3p KIT 1.28704406797397 1.17954701106157e-06 -3.33532221246538 5.36354430486114e-10 mirMAP -0.778831542315825 7.29328978606976e-08 NA NA NA hsa-miR-125a-3p KIT 1.19506542853853 0.00164364545717311 -3.33532221246538 5.36354430486114e-10 miRanda -0.318966721421995 0.0025253706672714 NA NA NA hsa-miR-128-3p KIT 0.98280381420517 5.77641850797209e-05 -3.33532221246538 5.36354430486114e-10 MirTarget -0.874953900602502 3.36351962635737e-08 NA NA NA hsa-miR-130b-3p KIT 1.32714007211004 4.78676252285191e-05 -3.33532221246538 5.36354430486114e-10 miRNATAP -0.686674632256951 4.36629799890082e-09 NA NA NA hsa-miR-142-5p KIT 1.55592486377018 6.69269968016779e-06 -3.33532221246538 5.36354430486114e-10 PITA;miRNATAP -0.31795809800069 0.00515222206463945 NA NA NA hsa-miR-193b-3p KIT 0.281752012268679 0.451258902263119 -3.33532221246538 5.36354430486114e-10 MirTarget;miRNATAP -0.420280907821218 7.88590038010478e-05 NA NA NA hsa-miR-19a-3p KIT 1.26669687448473 0.000105972838514412 -3.33532221246538 5.36354430486114e-10 miRTarBase;miRNATAP -0.494580974616647 3.59731270026218e-05 NA NA NA hsa-miR-19b-3p KIT 0.759818275708988 0.00652779573186786 -3.33532221246538 5.36354430486114e-10 miRNATAP -0.438659680261463 0.00221816743653445 NA NA NA hsa-miR-20a-5p KIT 1.4503375861709 5.7813456424762e-07 -3.33532221246538 5.36354430486114e-10 miRTarBase -0.666247140106509 4.53421650677625e-07 NA NA NA hsa-miR-221-3p KIT 1.33496247538338 3.82022531235275e-07 -3.33532221246538 5.36354430486114e-10 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.604461925069444 4.2460697504279e-05 NA NA NA hsa-miR-222-3p KIT 1.39382731585819 9.98182478024671e-07 -3.33532221246538 5.36354430486114e-10 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.50158065490246 0.000246393891203869 NA NA NA hsa-miR-301a-3p KIT 1.44721900431161 6.35068481036652e-06 -3.33532221246538 5.36354430486114e-10 miRNATAP -0.368287445064243 0.00264001195314497 NA NA NA hsa-miR-335-3p KIT 2.5197689063267 2.20084506976733e-09 -3.33532221246538 5.36354430486114e-10 mirMAP -0.458566715976481 2.57393601959522e-07 NA NA NA hsa-miR-335-5p KIT 1.59953351087307 5.56170899867314e-05 -3.33532221246538 5.36354430486114e-10 miRNAWalker2_validate -0.30483031884429 0.00208266201101367 NA NA NA hsa-miR-421 KIT 1.80720854070385 1.59709651202848e-07 -3.33532221246538 5.36354430486114e-10 miRanda -0.480032182318911 1.61505437326823e-05 NA NA NA hsa-miR-505-3p KIT 0.82660100642669 0.00111666333288398 -3.33532221246538 5.36354430486114e-10 MirTarget;miRNATAP -0.619295605268503 7.59316931695544e-05 NA NA NA hsa-miR-590-3p KIT 1.11654983899947 0.000160782154924864 -3.33532221246538 5.36354430486114e-10 miRanda;mirMAP -0.551250130230434 3.22536461118127e-05 NA NA NA hsa-miR-671-5p KIT 0.947458646379882 0.0024732430914236 -3.33532221246538 5.36354430486114e-10 MirTarget -0.486032819220924 0.000120130312458852 NA NA NA hsa-miR-126-5p KITLG 0.41765430251855 0.0753161203651532 -0.607435958715551 0.0719318599533199 mirMAP -0.303453273757017 0.00341568253113024 NA NA NA hsa-miR-142-5p KITLG 1.55592486377018 6.69269968016779e-06 -0.607435958715551 0.0719318599533199 MirTarget;PITA -0.223438305401041 0.00100350853220116 NA NA NA hsa-miR-17-3p KITLG 1.31126744284937 3.24768335024185e-07 -0.607435958715551 0.0719318599533199 MirTarget -0.337659809050111 0.000210714704718847 NA NA NA hsa-miR-32-3p KITLG 0.583525764322974 0.11837203008551 -0.607435958715551 0.0719318599533199 mirMAP -0.192413963699601 0.00804792243342359 NA NA NA hsa-miR-320b KITLG 1.11183660885284 0.000497971211648503 -0.607435958715551 0.0719318599533199 MirTarget;PITA;miRanda -0.213380632178247 0.004252072621555 NA NA NA hsa-miR-335-3p KITLG 2.5197689063267 2.20084506976733e-09 -0.607435958715551 0.0719318599533199 MirTarget -0.181659303251703 0.000850153035697802 NA NA NA hsa-miR-33a-3p KITLG 0.347011402017138 0.321709379745392 -0.607435958715551 0.0719318599533199 mirMAP -0.253185683355659 0.000449861177695944 NA NA NA hsa-miR-452-3p KITLG 2.2028815467959 0.00185370432491004 -0.607435958715551 0.0719318599533199 mirMAP -0.119703988766594 0.00151418203650555 NA NA NA hsa-miR-590-3p KITLG 1.11654983899947 0.000160782154924864 -0.607435958715551 0.0719318599533199 MirTarget;PITA;miRanda -0.242928577796156 0.00251186203169612 NA NA NA hsa-let-7a-3p KRAS 0.503048155002889 0.0411145454335299 0.0440663168558286 0.888218969585117 mirMAP;miRNATAP -0.274880026464494 0.00252165954052568 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-miR-143-3p KRAS -0.661937718854688 0.0483213962135842 0.0440663168558286 0.888218969585117 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.177845989861529 0.00743791491988655 22804917;27725862;19137007;26581910;23173124;26824186;21197560 In KRAS mutated tumours increased miR-200b and decreased miR-143 expression were associated with a good PFS;The expression of miR-143 is often down-regulated and it might play an important role by targeting KRAS in colorectal cancer CRC; Dual-luciferase reporter assays were performed to validate whether KRAS was regulated by miR-143; Dual-luciferase assays indicated that KRAS was a direct target of miR-143 as subsequently demonstrated by qPCR and western blot analysis showing that infection of SW480 cells with Ad-ZD55-miR-143 resulted in the down-regulation of KRAS at both mRNA and protein levels;Role of miR 143 targeting KRAS in colorectal tumorigenesis; In particular among a panel of presumed targets generated by in silico analysis that may interact with these aberrantly expressed miRNAs KRAS oncogene has been further experimentally validated as the target of miR-143; First an inverse correlation between KRAS protein and miR-143 in vivo was found; Second KRAS expression in Lovo cells was significantly abolished by treatment with miR-143 mimic whereas miR-143 inhibitor increased KRAS protein level; Third luciferase reporter assay confirmed that miR-143 directly recognize the 3'-untranslated region of KRAS transcripts; Finally inhibition of KRAS expression by miR-143 inhibits constitutive phosphorylation of ERK1/2; Taken together the present study provides the first evidences that miR-143 is significant in suppressing colorectal cancer cell growth through inhibition of KRAS translation;MicroRNA 143 replenishment re sensitizes colorectal cancer cells harboring mutant but not wild type KRAS to paclitaxel treatment; Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS; Combination of miR-143 mimic and paclitaxel induced the onset of apoptosis and reverted in vitro metastatic properties migration and invasion in KRAS mutant tumor cells; MiR-143 thus can be used as a chemosensitizer for the treatment of KRAS mutant tumors and warrants further investigations in in vitro and pre-clinical in vivo models;In turn the level of miR-143 in CRC cells decreasing the amount of MACC1 metastasis-associated in colon cancer-1 and oncogenic KRAS protein may be utilized as a prognostic marker;Stable miR-143 or miR-145 overexpression increased cell sensitivity to cetuximab resulting in a significant increase of cetuximab-mediated ADCC independently of KRAS status;miR 143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS; The expression level of miR-143 and its target gene KRAS were measured by realtime PCR and western blotting respectively; Our results revealed an inverse correlation of expression between miR-143 and KRAS protein in prostate cancer samples Pearson's correlation scatter plots: R = -0.707 P < 0.05; These findings suggest that miR-143 plays an important role in prostate cancer proliferation migration and chemosensitivity by suppressing KRAS and subsequent inactivation of MAPK pathway which provides a potential development of a new approach for the treatment of prostate cancer ;;tumorigenesis;;metastasis;; colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colon cancer;prostate cancer hsa-miR-193b-3p KRAS 0.281752012268679 0.451258902263119 0.0440663168558286 0.888218969585117 miRNAWalker2_validate;MirTarget;miRNATAP -0.202900424593209 0.000628014078688691 25905463 Deregulation of the MiR 193b KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer; Mechanistically KRAS was verified as a direct effector of miR-193b through which the AKT and ERK pathways were modulated and cell growth of PDAC cells was suppressed; Taken together our findings indicate that miR-193b-mediated deregulation of the KRAS axis is involved in pancreatic carcinogenesis and suggest that miR-193b could be a potentially effective target for PDAC therapy tumorigenesis pancreatic cancer hsa-miR-224-3p KRAS 1.52422171450716 0.00650463542340912 0.0440663168558286 0.888218969585117 mirMAP -0.113759821037082 0.00837068880275088 25919696 MicroRNA 224 is associated with colorectal cancer progression and response to 5 fluorouracil based chemotherapy by KRAS dependent and independent mechanisms; MicroRNA-224 was differentially expressed in dysplastic colorectal disease and in isogeneic KRAS WT and mutant HCT116 cells; 5-FU chemosensitivity was significantly increased in miR-224 knockdown cells and in NIH3T3 cells expressing KRAS and BRAF mutant proteins progression;drug resistance colorectal cancer hsa-miR-27b-3p KRAS 0.0836323965901755 0.725273923274 0.0440663168558286 0.888218969585117 miRNATAP -0.310127956853884 0.00104691607104432 NA NA NA hsa-miR-590-3p LAMA2 1.11654983899947 0.000160782154924864 -2.580924730533 3.63137417662178e-07 miRanda -0.509262836011672 3.60820492706287e-05 NA NA NA hsa-miR-32-3p LAMA4 0.583525764322974 0.11837203008551 -0.335332414229631 0.32993982166545 MirTarget -0.279822997204464 0.000129389747446573 NA NA NA hsa-miR-429 LAMA4 1.40182602301928 0.00900426780286475 -0.335332414229631 0.32993982166545 miRanda -0.215074305615025 1.16577579146537e-06 NA NA NA hsa-miR-590-3p LAMA4 1.11654983899947 0.000160782154924864 -0.335332414229631 0.32993982166545 miRanda -0.291271242280345 0.000343145331981654 NA NA NA hsa-miR-590-5p LAMA4 1.04171442093217 0.000272475544954865 -0.335332414229631 0.32993982166545 MirTarget;miRanda -0.357179682532611 1.98406831894934e-05 NA NA NA hsa-miR-93-3p LAMA4 1.88964231421793 1.80075645722786e-08 -0.335332414229631 0.32993982166545 miRNAWalker2_validate -0.294254447562209 2.2866757807666e-05 NA NA NA hsa-miR-196b-5p LAMB2 5.58954708296963 1.12099152907987e-19 -1.46371263481827 6.68247211232492e-08 miRNAWalker2_validate -0.149200081998869 1.63001646587031e-07 NA NA NA hsa-miR-34c-5p LAMB2 2.20632574870337 0.000379662996168678 -1.46371263481827 6.68247211232492e-08 miRanda -0.12738599133068 5.12824497263028e-05 NA NA NA hsa-miR-484 LAMB2 0.71327898984355 0.00233605130771196 -1.46371263481827 6.68247211232492e-08 miRNAWalker2_validate -0.474274449643981 1.02517472084591e-08 NA NA NA hsa-miR-107 LAMB4 0.904627575346218 4.67936495073904e-05 -2.85073188535029 0.000104195124925842 miRanda -0.678631753018377 0.00452665650429063 NA NA NA hsa-miR-16-5p LAMC1 1.00515772948091 5.33912942007619e-06 -0.087353699132084 0.738376666533912 miRNAWalker2_validate;MirTarget -0.221556573401183 0.00786443769780455 NA NA NA hsa-miR-200b-3p LAMC1 0.974577911407732 0.0595020056914543 -0.087353699132084 0.738376666533912 MirTarget;TargetScan -0.148045303530752 2.60969442358224e-05 NA NA NA hsa-miR-200c-3p LAMC1 1.28185685499076 0.00369777635539177 -0.087353699132084 0.738376666533912 MirTarget;miRNATAP -0.171869049690553 2.83063474350726e-05 NA NA NA hsa-miR-29a-3p LAMC1 -0.113012156986374 0.615005009685815 -0.087353699132084 0.738376666533912 MirTarget;miRNATAP -0.287557197309806 0.00058117288722877 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29b-3p LAMC1 -0.230693226193598 0.367461626035234 -0.087353699132084 0.738376666533912 MirTarget;miRNATAP -0.216042032630415 0.00316712813538642 NA NA NA hsa-miR-429 LAMC1 1.40182602301928 0.00900426780286475 -0.087353699132084 0.738376666533912 MirTarget;PITA;miRanda;miRNATAP -0.154255066108985 4.49497229292836e-06 NA NA NA hsa-miR-148b-3p LAMC2 0.295175884456199 0.17466422420702 2.65364471767322 5.14185338390863e-07 miRNAWalker2_validate -0.617031099386866 0.000641519294006906 NA NA NA hsa-miR-338-3p LAMC2 -0.959276231066179 0.0191473351014091 2.65364471767322 5.14185338390863e-07 miRanda -0.330967672847862 0.000413265986240392 NA NA NA hsa-miR-338-5p LAMC2 -1.19659203838734 0.0100316010080496 2.65364471767322 5.14185338390863e-07 mirMAP -0.280808735893256 0.000656583804816535 NA NA NA hsa-miR-375 LAMC2 -2.94506033785642 0.00570147601654791 2.65364471767322 5.14185338390863e-07 miRanda -0.201622460340746 6.63999491102235e-09 NA NA NA hsa-miR-660-5p LAMC2 -0.0206552819434673 0.938868734063643 2.65364471767322 5.14185338390863e-07 MirTarget -0.681988822774976 1.83599398734108e-06 NA NA NA hsa-miR-188-5p LPAR1 1.35426907033843 0.00038346077691455 -1.1445287421527 0.00599440235552658 MirTarget -0.359673885063411 2.14815245998416e-06 NA NA NA hsa-miR-200b-3p LPAR1 0.974577911407732 0.0595020056914543 -1.1445287421527 0.00599440235552658 MirTarget;TargetScan -0.285657236461803 3.65627964565427e-07 NA NA NA hsa-miR-200c-3p LPAR1 1.28185685499076 0.00369777635539177 -1.1445287421527 0.00599440235552658 miRNAWalker2_validate;MirTarget;miRNATAP -0.329960569361812 4.75128229187697e-07 NA NA NA hsa-miR-20a-3p LPAR1 1.13957127410163 0.000451087640268489 -1.1445287421527 0.00599440235552658 MirTarget -0.293790494652185 0.00121266853711735 NA NA NA hsa-miR-335-3p LPAR1 2.5197689063267 2.20084506976733e-09 -1.1445287421527 0.00599440235552658 mirMAP -0.275733967740521 3.99648637544292e-05 NA NA NA hsa-miR-421 LPAR1 1.80720854070385 1.59709651202848e-07 -1.1445287421527 0.00599440235552658 miRanda -0.275864317319787 0.000988497497884311 NA NA NA hsa-miR-429 LPAR1 1.40182602301928 0.00900426780286475 -1.1445287421527 0.00599440235552658 MirTarget;miRanda;miRNATAP -0.290841842113787 5.88133862969331e-08 NA NA NA hsa-miR-501-5p LPAR1 0.266919328110625 0.454779001968586 -1.1445287421527 0.00599440235552658 MirTarget;miRNATAP -0.368486058347126 8.32112134561334e-06 NA NA NA hsa-miR-576-5p LPAR1 0.625714137488957 0.0417100301848969 -1.1445287421527 0.00599440235552658 mirMAP -0.324932897935168 0.000811517730674961 NA NA NA hsa-miR-7-1-3p LPAR1 0.709309110750947 0.0412301737463194 -1.1445287421527 0.00599440235552658 MirTarget -0.370700473261319 1.20281827610823e-05 NA NA NA hsa-miR-143-3p LPAR2 -0.661937718854688 0.0483213962135842 0.519015949624137 0.0301445704926044 miRNATAP -0.133007081407301 0.0090449429956398 NA NA NA hsa-miR-200a-3p LPAR3 0.717826667295984 0.193912116506827 2.48324581864532 0.0243387454126263 MirTarget -0.515165481943613 0.000271003804783867 NA NA NA hsa-miR-222-5p LPAR4 1.87968474330782 1.11743009485711e-06 0.441298101093188 0.341478950986307 MirTarget -0.304740121169667 0.000224837620219308 NA NA NA hsa-miR-33a-3p LPAR4 0.347011402017138 0.321709379745392 0.441298101093188 0.341478950986307 MirTarget -0.44360651008269 5.93788270574925e-06 NA NA NA hsa-miR-3613-5p LPAR4 1.11821523851438 0.000249706750761735 0.441298101093188 0.341478950986307 miRNATAP -0.476382294436288 6.14834158416438e-06 NA NA NA hsa-miR-429 LPAR4 1.40182602301928 0.00900426780286475 0.441298101093188 0.341478950986307 miRNATAP -0.237766888866294 8.07443137669417e-05 NA NA NA hsa-miR-590-3p LPAR4 1.11654983899947 0.000160782154924864 0.441298101093188 0.341478950986307 MirTarget;miRanda;mirMAP -0.400455161690915 0.000261596926410511 NA NA NA hsa-miR-7-1-3p LPAR4 0.709309110750947 0.0412301737463194 0.441298101093188 0.341478950986307 mirMAP -0.265106914207607 0.00523289653236373 NA NA NA hsa-miR-186-5p LPAR5 0.149964130725901 0.434709542998771 0.0776771034066828 0.828825514542653 MirTarget -0.422425567969261 0.00192754887132402 NA NA NA hsa-miR-101-3p MAP2K1 -0.451263906815861 0.0283387250173031 0.350529324467741 0.0294686130211343 miRNAWalker2_validate -0.210543062942234 0.00016389062492995 NA NA NA hsa-miR-140-3p MAP2K1 -0.296251775392129 0.127539826012144 0.350529324467741 0.0294686130211343 PITA -0.25457882041555 1.7173921304805e-05 NA NA NA hsa-miR-30c-5p MAP2K1 -0.983130268805942 4.60419218706127e-05 0.350529324467741 0.0294686130211343 miRNAWalker2_validate -0.187593003082029 5.3436762450792e-05 NA NA NA hsa-miR-497-5p MAP2K1 -0.801030912431774 0.00360386743876612 0.350529324467741 0.0294686130211343 miRNAWalker2_validate -0.227085834893879 1.53919190373316e-08 NA NA NA hsa-miR-126-5p MAPK1 0.41765430251855 0.0753161203651532 -0.495098981122446 0.000571417199694919 mirMAP -0.124608202204108 0.00475675613750838 NA NA NA hsa-miR-140-3p MAPK1 -0.296251775392129 0.127539826012144 -0.495098981122446 0.000571417199694919 PITA;miRNATAP -0.145247944412064 0.0071251228758136 NA NA NA hsa-miR-140-5p MAPK1 0.208193069681326 0.303002433893804 -0.495098981122446 0.000571417199694919 miRanda -0.168814127617461 0.00108046906118217 NA NA NA hsa-miR-142-5p MAPK1 1.55592486377018 6.69269968016779e-06 -0.495098981122446 0.000571417199694919 mirMAP -0.122335014287939 1.92619380509704e-05 NA NA NA hsa-miR-16-5p MAPK1 1.00515772948091 5.33912942007619e-06 -0.495098981122446 0.000571417199694919 mirMAP -0.128343010905179 0.00527308486345473 NA NA NA hsa-miR-17-3p MAPK1 1.31126744284937 3.24768335024185e-07 -0.495098981122446 0.000571417199694919 mirMAP -0.106169760608366 0.00660645385547114 NA NA NA hsa-miR-32-5p MAPK1 0.415247682945382 0.106458022460373 -0.495098981122446 0.000571417199694919 mirMAP -0.131661373347466 0.00100556712965003 NA NA NA hsa-miR-320a MAPK1 0.593888711838028 0.011897419390526 -0.495098981122446 0.000571417199694919 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.124406693534882 0.00441330639927605 NA NA NA hsa-miR-320b MAPK1 1.11183660885284 0.000497971211648503 -0.495098981122446 0.000571417199694919 PITA;miRanda;miRNATAP -0.118699294587812 0.000165603061513233 NA NA NA hsa-miR-3614-3p MAPK1 0.816988052098069 0.0143572924352078 -0.495098981122446 0.000571417199694919 mirMAP -0.143042145876837 4.60745685333775e-06 NA NA NA hsa-let-7g-3p MCL1 0.64979533805273 0.0103084600883006 -0.138202903715657 0.474408611161361 MirTarget;miRNATAP -0.156077716412111 0.00392610130051262 NA NA NA hsa-miR-106a-5p MCL1 -0.173255688252641 0.642872703263671 -0.138202903715657 0.474408611161361 MirTarget;miRNATAP -0.109848211716182 0.00267957420291044 23904379 MiR 106a targets Mcl 1 to suppress cisplatin resistance of ovarian cancer A2780 cells; Real-time PCR Western blotting and luciferase reporter assay were applied to explore whether Mcl-1 was a target of miR-106a; Furthermore miR-106a inhibited cell survival and cisplatin resistance through downregulating the expression of Mcl-1; Mcl-1 was a direct target of miR-106a; These results suggest that miR-106a may provide a novel mechanism for understanding cisplatin resistance in ovarian cancer by modulating Mcl-1 drug resistance;poor survival ovarian cancer hsa-miR-106b-5p MCL1 1.70863907461894 2.04074794107142e-08 -0.138202903715657 0.474408611161361 MirTarget;miRNATAP -0.185644529972126 1.41401447467076e-05 NA NA NA hsa-miR-151a-3p MCL1 1.00322719901751 7.20903658270795e-06 -0.138202903715657 0.474408611161361 miRNAWalker2_validate -0.224236421762152 0.000191749091352345 NA NA NA hsa-miR-16-5p MCL1 1.00515772948091 5.33912942007619e-06 -0.138202903715657 0.474408611161361 miRNAWalker2_validate -0.164162422592807 0.0074819321694092 NA NA NA hsa-miR-335-3p MCL1 2.5197689063267 2.20084506976733e-09 -0.138202903715657 0.474408611161361 mirMAP -0.135307202176502 9.50739600380541e-06 NA NA NA hsa-miR-93-5p MCL1 1.7515174434778 1.59386482413883e-08 -0.138202903715657 0.474408611161361 MirTarget;miRNATAP -0.146795203725343 0.00052881026814203 NA NA NA hsa-miR-942-5p MCL1 1.90585138008274 3.11903311044863e-09 -0.138202903715657 0.474408611161361 MirTarget -0.114209719734715 0.00516364392056649 NA NA NA hsa-miR-143-3p MDM2 -0.661937718854688 0.0483213962135842 0.0953337413007871 0.725153770779448 miRNAWalker2_validate -0.192980048252097 0.000726275884433861 NA NA NA hsa-miR-139-5p MET -1.83374360776637 1.22019901002824e-09 1.09146649208404 0.00117906068907057 miRanda -0.24593624886584 0.0013860217001924 NA NA NA hsa-miR-23b-3p MET -0.286465516491361 0.18664668472995 1.09146649208404 0.00117906068907057 miRNAWalker2_validate;miRTarBase -0.36770947393715 0.00116708700486341 19490101 MicroRNA 23b mediates urokinase and c met downmodulation and a decreased migration of human hepatocellular carcinoma cells; In the present study to understand whether the expression of these genes might be coregulated by specific microRNAs miRs in human cells we predicted that Homo sapiens microRNA-23b could recognize two sites in the 3'-UTR of uPA and four sites in the c-met 3'-UTR by the algorithm pictar; The evidence obtained shows that overexpression of miR-23b leads to uPA and c-met downregulation and to decreased migration and proliferation abilities of HCC cells liver cancer hsa-miR-30e-3p MET -0.913131357083321 7.29096855615228e-06 1.09146649208404 0.00117906068907057 mirMAP -0.405368273360062 0.000591001266617717 NA NA NA hsa-miR-340-5p MET -0.164941927483643 0.529910509321278 1.09146649208404 0.00117906068907057 miRNAWalker2_validate;miRTarBase -0.476856920131876 1.58791963714124e-07 24448820;21692045 It was of note that the colorectal cancer group with low miR-340 and high c-Met expression had the worst prognosis;miR 340 inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c Met; Ex vivo loss of miR-340 expression was associated with lymph node metastasis high tumor histological grade clinical stage and shorter overall survival of breast cancer as well as increased c-Met expression in breast cancer tissue specimens worse prognosis;cell migration;staging;metastasis;poor survival colorectal cancer;breast cancer hsa-miR-361-5p MET 0.407725414130987 0.0181260969156347 1.09146649208404 0.00117906068907057 PITA;miRanda -0.423329864611604 0.00332602842271318 NA NA NA hsa-miR-374a-5p MET -0.116485410477589 0.554703396010082 1.09146649208404 0.00117906068907057 mirMAP -0.374730510349824 0.00289010914037555 NA NA NA hsa-miR-664a-3p MET -0.83041219170254 0.000136267547251167 1.09146649208404 0.00117906068907057 mirMAP -0.372775395356499 0.000770233233738383 NA NA NA hsa-miR-628-5p MTCP1 -0.535322919688788 0.0377881249470294 -0.0168461923834698 0.937344437725962 PITA;miRNATAP -0.176636134401579 0.00282064637483768 NA NA NA hsa-miR-127-3p MYB 0.211466568760589 0.46101284760949 2.51114516034844 0.000404336548143311 miRanda -0.541042662623729 0.00267224996746884 NA NA NA hsa-miR-193b-3p MYB 0.281752012268679 0.451258902263119 2.51114516034844 0.000404336548143311 miRNAWalker2_validate -1.0491300263411 2.00534453590592e-16 NA NA NA hsa-miR-34c-5p MYB 2.20632574870337 0.000379662996168678 2.51114516034844 0.000404336548143311 miRNAWalker2_validate;PITA;miRanda -0.271656824276794 0.000855360123070138 NA NA NA hsa-miR-455-5p MYB 1.20462751989145 6.74386011867484e-05 2.51114516034844 0.000404336548143311 miRanda -0.551146049022783 0.000964031646026291 NA NA NA hsa-let-7g-5p MYC 0.325297685027927 0.241142963826631 0.519157788027723 0.0906694636452631 miRNAWalker2_validate;miRTarBase -0.208004338135784 0.00889968380877331 NA NA NA hsa-miR-26a-5p MYC -0.384110714440647 0.0442498636014044 0.519157788027723 0.0906694636452631 miRNAWalker2_validate -0.595250601703361 1.86863162610225e-07 21901171 Our results identify new molecular targets of c-Myc in AML and highlight miR-26a attractiveness as a therapeutic target in leukemia acute myeloid leukemia hsa-miR-335-5p MYC 1.59953351087307 5.56170899867314e-05 0.519157788027723 0.0906694636452631 miRNAWalker2_validate -0.211331388667708 7.8766835557931e-05 NA NA NA hsa-miR-34a-5p MYC 0.794251341270032 0.00024017386701179 0.519157788027723 0.0906694636452631 miRNAWalker2_validate;miRTarBase -0.342899797750895 0.000672118391671011 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-423-5p MYC 0.832613878736338 0.000791321227103338 0.519157788027723 0.0906694636452631 miRNAWalker2_validate -0.242528994449528 0.00588609161419062 NA NA NA hsa-let-7f-5p NGF 0.634633924115866 0.0344982923411787 -0.0044354260251589 0.994557609636983 MirTarget -0.455658818520987 0.00313618077968416 NA NA NA hsa-let-7g-5p NGF 0.325297685027927 0.241142963826631 -0.0044354260251589 0.994557609636983 MirTarget -0.833551967281976 3.8902528304102e-07 NA NA NA hsa-miR-423-5p NGF 0.832613878736338 0.000791321227103338 -0.0044354260251589 0.994557609636983 MirTarget;miRNATAP -0.706016056377721 0.0001322029752225 NA NA NA hsa-miR-429 NGF 1.40182602301928 0.00900426780286475 -0.0044354260251589 0.994557609636983 miRanda -0.396695496445767 2.17739891550587e-06 NA NA NA hsa-miR-10a-5p NGFR -0.470861534765518 0.148803248989189 -1.73466388982039 0.0507168927156123 mirMAP -0.655944380730205 0.000740118227620395 NA NA NA hsa-miR-148b-5p NGFR 1.04409494910362 0.00195860954157389 -1.73466388982039 0.0507168927156123 mirMAP -0.664475438733519 0.000347024130079685 NA NA NA hsa-miR-194-3p NGFR 0.259420201261466 0.821811295418686 -1.73466388982039 0.0507168927156123 mirMAP -0.543264706935227 6.86605025324571e-30 NA NA NA hsa-miR-2110 NGFR 0.759864042760204 0.0723961390557655 -1.73466388982039 0.0507168927156123 mirMAP -0.888664374578289 1.2224682980101e-09 NA NA NA hsa-miR-30b-3p NGFR -0.266398938200332 0.400847813143994 -1.73466388982039 0.0507168927156123 mirMAP -0.631471380811439 0.00166272552987571 NA NA NA hsa-miR-326 NGFR -0.429748586406214 0.2629894124021 -1.73466388982039 0.0507168927156123 miRanda;mirMAP -0.612828274615561 0.000225550321617984 NA NA NA hsa-miR-335-5p NGFR 1.59953351087307 5.56170899867314e-05 -1.73466388982039 0.0507168927156123 miRNAWalker2_validate -0.631051526978649 4.83987514130979e-05 NA NA NA hsa-miR-34a-5p NGFR 0.794251341270032 0.00024017386701179 -1.73466388982039 0.0507168927156123 mirMAP -1.41009174140321 1.00424432427002e-06 NA NA NA hsa-miR-361-3p NGFR -0.126462931388735 0.566052688733137 -1.73466388982039 0.0507168927156123 mirMAP -0.975124688217581 0.000853156267133635 NA NA NA hsa-miR-3614-5p NGFR 1.10426689932954 0.00706308396674599 -1.73466388982039 0.0507168927156123 mirMAP -0.894416105030557 2.76089018532704e-09 NA NA NA hsa-miR-429 NGFR 1.40182602301928 0.00900426780286475 -1.73466388982039 0.0507168927156123 miRNATAP -0.588824010286522 2.62214803568559e-07 NA NA NA hsa-miR-625-5p NGFR 0.537211086526376 0.203801009380384 -1.73466388982039 0.0507168927156123 mirMAP -1.07769856228856 2.78511975581827e-14 NA NA NA hsa-miR-542-3p NOS3 0.757649022262991 0.00210575463285599 -0.498491172500839 0.181081624890022 miRanda -0.306775573263927 0.00446104048890028 NA NA NA hsa-let-7c-5p NRAS -0.503482361446512 0.206848395212976 0.606733058105388 0.0107700909176788 miRNAWalker2_validate;miRTarBase;MirTarget -0.124225168269858 0.00351586115791848 NA NA NA hsa-miR-145-5p NRAS -1.75133578902314 1.54965572197748e-05 0.606733058105388 0.0107700909176788 miRNAWalker2_validate;MirTarget;miRNATAP -0.113590801226011 0.00562715254109734 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-26a-5p NRAS -0.384110714440647 0.0442498636014044 0.606733058105388 0.0107700909176788 mirMAP;miRNATAP -0.253407088765911 0.00536728320880026 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-28-5p NRAS -0.238617853755144 0.167318538669818 0.606733058105388 0.0107700909176788 MirTarget;PITA;miRanda;miRNATAP -0.309483366881585 0.00227879779800337 NA NA NA hsa-miR-29c-3p NRAS -1.62454036584589 5.38376515586029e-07 0.606733058105388 0.0107700909176788 miRNATAP -0.175997480071788 0.000530133170369644 NA NA NA hsa-miR-21-5p NTF3 1.75445050487988 2.41825549682022e-23 -1.62090037978398 0.0028979647870912 miRTarBase;miRNATAP -0.654434459929646 0.00114877436972271 NA NA NA hsa-miR-107 NTRK2 0.904627575346218 4.67936495073904e-05 0.129052700235785 0.904324328702051 PITA;miRanda -1.24910626177656 0.00024341170686849 NA NA NA hsa-miR-140-3p NTRK2 -0.296251775392129 0.127539826012144 0.129052700235785 0.904324328702051 PITA -1.43629375239255 0.000327819599110366 NA NA NA hsa-miR-148a-5p NTRK2 -0.69329616490858 0.0793012233740369 0.129052700235785 0.904324328702051 mirMAP -0.62690136997922 0.00111999270999755 NA NA NA hsa-miR-186-5p NTRK2 0.149964130725901 0.434709542998771 0.129052700235785 0.904324328702051 mirMAP -1.53387891250486 0.000154763882037282 NA NA NA hsa-miR-29a-5p NTRK2 0.585084040404152 0.023014129158495 0.129052700235785 0.904324328702051 mirMAP -1.1189889083857 0.000158182837179273 NA NA NA hsa-miR-30d-3p NTRK2 -0.545113326540761 0.0433733076874155 0.129052700235785 0.904324328702051 mirMAP -0.840024189446887 0.00314885294170295 NA NA NA hsa-miR-30d-5p NTRK2 -0.5492586056147 0.0140125082460125 0.129052700235785 0.904324328702051 mirMAP -1.08205944732444 0.00168936814844951 NA NA NA hsa-miR-326 NTRK2 -0.429748586406214 0.2629894124021 0.129052700235785 0.904324328702051 miRanda -1.0084031919731 2.97462223495207e-07 NA NA NA hsa-miR-330-5p NTRK2 0.488365986827708 0.0512207630808233 0.129052700235785 0.904324328702051 miRanda -1.10006559956903 0.000320304929154941 NA NA NA hsa-miR-335-5p NTRK2 1.59953351087307 5.56170899867314e-05 0.129052700235785 0.904324328702051 miRNAWalker2_validate -0.554413660240109 0.00332406257269656 NA NA NA hsa-miR-338-3p NTRK2 -0.959276231066179 0.0191473351014091 0.129052700235785 0.904324328702051 miRanda -1.15537671088924 7.88265095662026e-11 NA NA NA hsa-miR-362-5p NTRK2 -0.354508685915981 0.354912078595613 0.129052700235785 0.904324328702051 mirMAP -0.973937329266648 6.24360566263495e-07 NA NA NA hsa-miR-501-5p NTRK2 0.266919328110625 0.454779001968586 0.129052700235785 0.904324328702051 mirMAP -1.02102960533135 1.21803450026443e-06 NA NA NA hsa-miR-532-5p NTRK2 0.313080805824184 0.252248939356301 0.129052700235785 0.904324328702051 PITA -1.59975014566445 4.3572070168858e-09 NA NA NA hsa-miR-577 NTRK2 0.911619788986754 0.2256062124148 0.129052700235785 0.904324328702051 mirMAP -0.449281370294781 1.07363179810198e-05 NA NA NA hsa-let-7d-5p OSMR 0.981733854788227 7.26366577706469e-07 0.590228118350084 0.0812933663771449 miRNATAP -0.339681364272053 0.00496611114718156 NA NA NA hsa-let-7g-5p OSMR 0.325297685027927 0.241142963826631 0.590228118350084 0.0812933663771449 miRNATAP -0.314063202702883 0.000311942259010435 NA NA NA hsa-miR-1254 OSMR 0.941374574140312 0.0605480748500796 0.590228118350084 0.0812933663771449 MirTarget -0.151695339983525 0.00876421469129444 NA NA NA hsa-miR-200b-3p OSMR 0.974577911407732 0.0595020056914543 0.590228118350084 0.0812933663771449 TargetScan -0.225656129510987 6.7751150942655e-07 NA NA NA hsa-miR-335-5p OSMR 1.59953351087307 5.56170899867314e-05 0.590228118350084 0.0812933663771449 miRNAWalker2_validate -0.282216408467629 1.4251612735117e-06 NA NA NA hsa-miR-429 OSMR 1.40182602301928 0.00900426780286475 0.590228118350084 0.0812933663771449 miRanda;miRNATAP -0.217215075958494 6.16481777674182e-07 NA NA NA hsa-miR-616-5p OSMR 0.834052908652744 0.0347835664029363 0.590228118350084 0.0812933663771449 MirTarget -0.164539260974257 0.00807935806779158 NA NA NA hsa-miR-98-5p OSMR 0.919961309193122 2.61963790596372e-05 0.590228118350084 0.0812933663771449 miRNAWalker2_validate -0.329012764090757 0.00271809883209831 NA NA NA hsa-miR-199a-5p PCK1 0.371973504507027 0.232661597228763 0.614573124296183 0.616171324319371 miRanda -0.883560168560817 0.00164898644861409 NA NA NA hsa-miR-142-5p PDGFC 1.55592486377018 6.69269968016779e-06 -0.428293827442733 0.270026432499587 PITA -0.236484087228797 0.00247789392813088 NA NA NA hsa-miR-16-2-3p PDGFC 1.8048179609245 2.83095715136409e-09 -0.428293827442733 0.270026432499587 mirMAP -0.232746401733619 0.00795227840193951 NA NA NA hsa-miR-330-3p PDGFC 0.798460296022179 0.00746538156533435 -0.428293827442733 0.270026432499587 mirMAP -0.247895978465434 0.00739243902040488 NA NA NA hsa-miR-335-3p PDGFC 2.5197689063267 2.20084506976733e-09 -0.428293827442733 0.270026432499587 mirMAP -0.302703493361235 8.49467442588613e-07 NA NA NA hsa-miR-338-5p PDGFC -1.19659203838734 0.0100316010080496 -0.428293827442733 0.270026432499587 PITA;mirMAP -0.169288808465861 0.0040704717189607 NA NA NA hsa-miR-375 PDGFC -2.94506033785642 0.00570147601654791 -0.428293827442733 0.270026432499587 miRNAWalker2_validate;miRanda -0.112311266377289 8.21945774612344e-06 NA NA NA hsa-miR-7-1-3p PDGFC 0.709309110750947 0.0412301737463194 -0.428293827442733 0.270026432499587 mirMAP -0.363138642084197 3.27858616400315e-06 NA NA NA hsa-miR-7-5p PDGFC 1.63575693499363 0.0124424214624534 -0.428293827442733 0.270026432499587 miRNAWalker2_validate -0.125146317265827 0.00428044087803375 NA NA NA hsa-miR-125a-3p PDGFD 1.19506542853853 0.00164364545717311 -2.39203189150505 1.46051478070069e-07 miRanda -0.253230959321392 0.00412925400508089 NA NA NA hsa-miR-203a-3p PDGFD 1.44736908507496 0.0394116388736904 -2.39203189150505 1.46051478070069e-07 MirTarget -0.316546426347305 1.65912418696073e-12 NA NA NA hsa-miR-21-5p PDGFD 1.75445050487988 2.41825549682022e-23 -2.39203189150505 1.46051478070069e-07 miRNAWalker2_validate -0.491608165328088 0.00444359752142511 NA NA NA hsa-miR-331-5p PDGFD 1.0778596491846 2.79470024753813e-05 -2.39203189150505 1.46051478070069e-07 MirTarget -0.396625771818996 0.00204623350374034 NA NA NA hsa-miR-335-3p PDGFD 2.5197689063267 2.20084506976733e-09 -2.39203189150505 1.46051478070069e-07 mirMAP -0.207387134505796 0.00647284271479664 NA NA NA hsa-miR-590-5p PDGFD 1.04171442093217 0.000272475544954865 -2.39203189150505 1.46051478070069e-07 miRanda -0.404193042372488 0.000465242063829015 NA NA NA hsa-miR-944 PDGFD 3.33123095809751 0.0177835044930391 -2.39203189150505 1.46051478070069e-07 MirTarget;mirMAP -0.203792684451537 8.867679349447e-15 NA NA NA hsa-let-7a-3p PDGFRA 0.503048155002889 0.0411145454335299 -1.16052455489929 0.00469457800041433 mirMAP -0.408353851698219 0.000676900473184116 NA NA NA hsa-let-7b-3p PDGFRA 0.21838629112113 0.296038413622566 -1.16052455489929 0.00469457800041433 mirMAP -0.396878610010639 0.00585973151537375 NA NA NA hsa-let-7b-5p PDGFRA 0.0582902155815681 0.781400138984745 -1.16052455489929 0.00469457800041433 miRNAWalker2_validate -0.476383510169118 0.000849680543371195 NA NA NA hsa-let-7f-1-3p PDGFRA 1.28704406797397 1.17954701106157e-06 -1.16052455489929 0.00469457800041433 mirMAP -0.510677857296601 1.86478326712873e-06 NA NA NA hsa-let-7g-3p PDGFRA 0.64979533805273 0.0103084600883006 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.427053544147745 0.000232980860387631 NA NA NA hsa-miR-106b-5p PDGFRA 1.70863907461894 2.04074794107142e-08 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.309529989101084 0.000900259038001664 NA NA NA hsa-miR-130b-3p PDGFRA 1.32714007211004 4.78676252285191e-05 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.323034116833204 0.000252646518119505 NA NA NA hsa-miR-141-3p PDGFRA 1.45548825076434 0.00115958850961764 -1.16052455489929 0.00469457800041433 MirTarget -0.272935688822065 2.05225184731917e-05 NA NA NA hsa-miR-149-5p PDGFRA 0.706277554734069 0.296848731347677 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.204884142254506 1.43284462144315e-06 NA NA NA hsa-miR-16-1-3p PDGFRA 1.43227522002564 3.70920454953168e-08 -1.16052455489929 0.00469457800041433 MirTarget -0.386511551403792 0.000421130307898712 NA NA NA hsa-miR-17-5p PDGFRA 1.65862087862483 8.45603406215941e-08 -1.16052455489929 0.00469457800041433 MirTarget;TargetScan;miRNATAP -0.356393358462224 9.88240800111174e-05 NA NA NA hsa-miR-182-5p PDGFRA 0.887369486030646 0.0310640781418789 -1.16052455489929 0.00469457800041433 miRNATAP -0.360773153367445 2.16793167252092e-07 NA NA NA hsa-miR-196a-5p PDGFRA 6.59255881689547 1.53691144193899e-22 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.111949684332786 0.00385048520276526 NA NA NA hsa-miR-196b-5p PDGFRA 5.58954708296963 1.12099152907987e-19 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.130835032420459 0.00238656958843899 NA NA NA hsa-miR-20a-5p PDGFRA 1.4503375861709 5.7813456424762e-07 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.290949630098886 0.00333304913306046 NA NA NA hsa-miR-219a-5p PDGFRA 0.605535434887599 0.0854495887591817 -1.16052455489929 0.00469457800041433 MirTarget -0.334702476451174 5.59649998290824e-05 NA NA NA hsa-miR-224-5p PDGFRA 2.7648036144402 0.000111736336240167 -1.16052455489929 0.00469457800041433 MirTarget -0.202264857356356 2.7344531322204e-07 NA NA NA hsa-miR-24-3p PDGFRA 1.08578167539644 6.18549359075268e-07 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.80542708487755 3.49721401699797e-10 NA NA NA hsa-miR-27a-3p PDGFRA 1.29886998470345 2.68986118553486e-08 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.749473123725816 2.3288170404456e-10 NA NA NA hsa-miR-27b-3p PDGFRA 0.0836323965901755 0.725273923274 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.502143905481073 5.44941103065583e-05 NA NA NA hsa-miR-301a-3p PDGFRA 1.44721900431161 6.35068481036652e-06 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.240717213465514 0.00761366951584292 NA NA NA hsa-miR-3065-5p PDGFRA -0.241623656423063 0.633116553078159 -1.16052455489929 0.00469457800041433 mirMAP -0.154613330078393 0.00962944858215771 NA NA NA hsa-miR-330-5p PDGFRA 0.488365986827708 0.0512207630808233 -1.16052455489929 0.00469457800041433 miRanda -0.311345692720835 0.00879331340845444 NA NA NA hsa-miR-335-3p PDGFRA 2.5197689063267 2.20084506976733e-09 -1.16052455489929 0.00469457800041433 mirMAP -0.180474779188923 0.00708107448376463 NA NA NA hsa-miR-33a-5p PDGFRA 0.407757858040717 0.321429014317207 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.38674069592567 2.76867912009244e-08 NA NA NA hsa-miR-33b-5p PDGFRA 0.267227362818466 0.614814331176942 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.330006551788421 2.87405240493235e-06 NA NA NA hsa-miR-34c-5p PDGFRA 2.20632574870337 0.000379662996168678 -1.16052455489929 0.00469457800041433 MirTarget;PITA;miRanda;miRNATAP -0.121772445130468 0.00965103598609489 NA NA NA hsa-miR-590-5p PDGFRA 1.04171442093217 0.000272475544954865 -1.16052455489929 0.00469457800041433 miRanda -0.480670069602324 1.60944318294763e-06 NA NA NA hsa-miR-93-5p PDGFRA 1.7515174434778 1.59386482413883e-08 -1.16052455489929 0.00469457800041433 MirTarget;miRNATAP -0.257971477859351 0.00500909640090511 NA NA NA hsa-miR-944 PDGFRA 3.33123095809751 0.0177835044930391 -1.16052455489929 0.00469457800041433 mirMAP -0.137440077961584 9.05523929015606e-09 NA NA NA hsa-miR-96-5p PDGFRA 1.14243043653372 0.00942969392739105 -1.16052455489929 0.00469457800041433 TargetScan;miRNATAP -0.367778743049386 5.89709579941633e-08 NA NA NA hsa-miR-3127-5p PDGFRB 0.98677589413294 0.00734249049849 0.844690963059587 0.0248980975397874 mirMAP -0.216339467888686 0.00297551716216838 NA NA NA hsa-miR-664a-3p PDGFRB -0.83041219170254 0.000136267547251167 0.844690963059587 0.0248980975397874 MirTarget -0.351564932871264 0.00450301463469565 NA NA NA hsa-miR-22-5p PDPK1 0.804348748654247 0.000804065112767412 -0.585978828653773 3.50244194477713e-05 miRNATAP -0.125270641474765 0.00305655303487416 NA NA NA hsa-miR-24-3p PDPK1 1.08578167539644 6.18549359075268e-07 -0.585978828653773 3.50244194477713e-05 miRNAWalker2_validate -0.136688130392664 0.00295230377218292 NA NA NA hsa-miR-27a-3p PDPK1 1.29886998470345 2.68986118553486e-08 -0.585978828653773 3.50244194477713e-05 miRNATAP -0.125391103303215 0.00310988885070073 NA NA NA hsa-miR-424-5p PDPK1 1.08509868581983 0.000420473853818268 -0.585978828653773 3.50244194477713e-05 mirMAP -0.125125661094248 0.00011372244973578 NA NA NA hsa-miR-542-3p PDPK1 0.757649022262991 0.00210575463285599 -0.585978828653773 3.50244194477713e-05 mirMAP -0.156103483841085 0.000137438870707711 NA NA NA hsa-miR-326 PGF -0.429748586406214 0.2629894124021 2.28861179569536 2.11563176368074e-07 mirMAP -0.24624077215828 0.00397086059498227 NA NA NA hsa-miR-335-5p PGF 1.59953351087307 5.56170899867314e-05 2.28861179569536 2.11563176368074e-07 miRNATAP -0.282601191101352 0.000396116789925528 NA NA NA hsa-miR-429 PGF 1.40182602301928 0.00900426780286475 2.28861179569536 2.11563176368074e-07 miRNATAP -0.171535690837198 0.00414084556636762 NA NA NA hsa-miR-149-5p PHLPP2 0.706277554734069 0.296848731347677 -0.0375439483818423 0.880559627422566 MirTarget;miRNATAP -0.102881065496088 6.54453368850429e-05 NA NA NA hsa-miR-27a-3p PHLPP2 1.29886998470345 2.68986118553486e-08 -0.0375439483818423 0.880559627422566 MirTarget;miRNATAP -0.413056953017386 8.18525781939067e-09 NA NA NA hsa-miR-27b-3p PHLPP2 0.0836323965901755 0.725273923274 -0.0375439483818423 0.880559627422566 MirTarget;miRNATAP -0.362016686610018 1.00390777884191e-06 NA NA NA hsa-miR-32-5p PHLPP2 0.415247682945382 0.106458022460373 -0.0375439483818423 0.880559627422566 miRNAWalker2_validate;MirTarget;miRNATAP -0.211362531562688 0.00230025251519751 26276160 MiR 32 contributed to cell proliferation of human breast cancer cells by suppressing of PHLPP2 expression; Mechanically data from luciferase reporter assays revealed that miR-32 directly targeted to the 3'-untranslated region 3'-UTR of PHLPP2 breast cancer hsa-miR-330-3p PHLPP2 0.798460296022179 0.00746538156533435 -0.0375439483818423 0.880559627422566 mirMAP;miRNATAP -0.202759612278121 0.000581025453432403 NA NA NA hsa-miR-126-5p PIK3CA 0.41765430251855 0.0753161203651532 0.181162005416898 0.379919524282219 mirMAP -0.230165325454576 0.000229328041159233 NA NA NA hsa-miR-146a-5p PIK3CA 1.82051649415508 2.03651725047679e-05 0.181162005416898 0.379919524282219 mirMAP -0.130514283326015 8.03472410512393e-05 NA NA NA hsa-miR-148a-5p PIK3CA -0.69329616490858 0.0793012233740369 0.181162005416898 0.379919524282219 mirMAP -0.160710142606256 9.74691916818117e-06 NA NA NA hsa-miR-148b-3p PIK3CA 0.295175884456199 0.17466422420702 0.181162005416898 0.379919524282219 miRNAWalker2_validate -0.270665697414514 6.25461929338548e-05 NA NA NA hsa-miR-186-5p PIK3CA 0.149964130725901 0.434709542998771 0.181162005416898 0.379919524282219 mirMAP -0.283664174467296 0.000254482000083255 NA NA NA hsa-miR-29b-1-5p PIK3CA 0.606560155953522 0.116355599574769 0.181162005416898 0.379919524282219 mirMAP -0.105962073023743 0.00514891759991948 NA NA NA hsa-miR-320b PIK3CA 1.11183660885284 0.000497971211648503 0.181162005416898 0.379919524282219 miRanda -0.131928082159166 0.00355606170878243 NA NA NA hsa-miR-335-5p PIK3CA 1.59953351087307 5.56170899867314e-05 0.181162005416898 0.379919524282219 miRNAWalker2_validate -0.142668444274705 6.55217134166698e-05 NA NA NA hsa-miR-338-5p PIK3CA -1.19659203838734 0.0100316010080496 0.181162005416898 0.379919524282219 mirMAP -0.128160056012068 3.12181075963217e-05 NA NA NA hsa-miR-501-5p PIK3CA 0.266919328110625 0.454779001968586 0.181162005416898 0.379919524282219 mirMAP -0.184484665922465 4.78508048904086e-06 NA NA NA hsa-miR-7-1-3p PIK3CA 0.709309110750947 0.0412301737463194 0.181162005416898 0.379919524282219 mirMAP -0.18347710340594 9.07765701687707e-06 NA NA NA hsa-miR-130a-3p PIK3CB 0.146223920674657 0.633739795905839 0.248944033508746 0.180378115579181 miRNATAP -0.141347568269357 0.0010035949231668 NA NA NA hsa-miR-1468-5p PIK3CD -1.88350218312373 3.31332405201189e-05 0.391814669139483 0.253077445924908 MirTarget -0.217696918010317 3.06934786857079e-05 NA NA NA hsa-miR-30b-3p PIK3CD -0.266398938200332 0.400847813143994 0.391814669139483 0.253077445924908 MirTarget -0.431008741394064 8.57729594514163e-09 NA NA NA hsa-miR-30b-5p PIK3CD -0.430720743745757 0.0593564057320791 0.391814669139483 0.253077445924908 MirTarget -0.481822586915696 5.93876910377637e-06 NA NA NA hsa-miR-30d-5p PIK3CD -0.5492586056147 0.0140125082460125 0.391814669139483 0.253077445924908 MirTarget;miRNATAP -0.669349357920634 2.53796175626459e-10 NA NA NA hsa-miR-616-5p PIK3CD 0.834052908652744 0.0347835664029363 0.391814669139483 0.253077445924908 MirTarget -0.171408745877689 0.0062816347712319 NA NA NA hsa-miR-7-5p PIK3CD 1.63575693499363 0.0124424214624534 0.391814669139483 0.253077445924908 miRTarBase;MirTarget;miRNATAP -0.205801781586893 4.40558507915807e-08 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway liver cancer hsa-miR-103a-3p PIK3R1 0.840525139266028 5.83536475789158e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.323457232113071 0.0039447769693221 NA NA NA hsa-miR-106b-5p PIK3R1 1.70863907461894 2.04074794107142e-08 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.253346436583178 1.72729352701852e-05 NA NA NA hsa-miR-107 PIK3R1 0.904627575346218 4.67936495073904e-05 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda;miRNATAP -0.238654922729134 0.0046938788179217 NA NA NA hsa-miR-128-3p PIK3R1 0.98280381420517 5.77641850797209e-05 -1.09428616452248 2.46783518047221e-05 MirTarget -0.253825409257793 0.000861541031670611 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-144-3p PIK3R1 -0.13309578176575 0.798245647923351 -1.09428616452248 2.46783518047221e-05 mirMAP -0.138673461850839 0.000126186382128809 NA NA NA hsa-miR-15b-5p PIK3R1 1.62046407540723 5.42152621571078e-09 -1.09428616452248 2.46783518047221e-05 MirTarget -0.323211150072369 4.46298725379362e-07 NA NA NA hsa-miR-16-2-3p PIK3R1 1.8048179609245 2.83095715136409e-09 -1.09428616452248 2.46783518047221e-05 MirTarget -0.270383492169966 3.99207467881518e-06 NA NA NA hsa-miR-16-5p PIK3R1 1.00515772948091 5.33912942007619e-06 -1.09428616452248 2.46783518047221e-05 MirTarget -0.405416526556489 9.69480909855754e-07 NA NA NA hsa-miR-17-5p PIK3R1 1.65862087862483 8.45603406215941e-08 -1.09428616452248 2.46783518047221e-05 MirTarget;TargetScan;miRNATAP -0.192199170444737 0.00107429271534319 NA NA NA hsa-miR-182-5p PIK3R1 0.887369486030646 0.0310640781418789 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.160218491940506 0.000398426335382569 NA NA NA hsa-miR-185-5p PIK3R1 1.14351510556643 1.07346945085714e-08 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.41775889137189 4.21636400438791e-06 NA NA NA hsa-miR-188-5p PIK3R1 1.35426907033843 0.00038346077691455 -1.09428616452248 2.46783518047221e-05 MirTarget -0.162900447887926 0.000775923703794411 NA NA NA hsa-miR-200b-3p PIK3R1 0.974577911407732 0.0595020056914543 -1.09428616452248 2.46783518047221e-05 mirMAP -0.103803538669649 0.00409847558383849 NA NA NA hsa-miR-200c-3p PIK3R1 1.28185685499076 0.00369777635539177 -1.09428616452248 2.46783518047221e-05 mirMAP -0.143316221972735 0.00063899158230993 NA NA NA hsa-miR-20a-5p PIK3R1 1.4503375861709 5.7813456424762e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.175478538743826 0.0056099063555159 NA NA NA hsa-miR-21-5p PIK3R1 1.75445050487988 2.41825549682022e-23 -1.09428616452248 2.46783518047221e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.306402457018565 0.00154965993784699 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.960352937108106 0.00133449812322732 -1.09428616452248 2.46783518047221e-05 MirTarget -0.22956448368642 0.000224776230276284 NA NA NA hsa-miR-22-5p PIK3R1 0.804348748654247 0.000804065112767412 -1.09428616452248 2.46783518047221e-05 mirMAP -0.271562984507077 0.000499671844853285 NA NA NA hsa-miR-221-3p PIK3R1 1.33496247538338 3.82022531235275e-07 -1.09428616452248 2.46783518047221e-05 MirTarget -0.313499877783358 5.35467630228685e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.39382731585819 9.98182478024671e-07 -1.09428616452248 2.46783518047221e-05 MirTarget -0.284754511073413 7.61572703183408e-06 NA NA NA hsa-miR-3065-5p PIK3R1 -0.241623656423063 0.633116553078159 -1.09428616452248 2.46783518047221e-05 MirTarget;mirMAP;miRNATAP -0.124182539774803 0.00105993614946939 NA NA NA hsa-miR-32-3p PIK3R1 0.583525764322974 0.11837203008551 -1.09428616452248 2.46783518047221e-05 mirMAP -0.17265888879632 0.00228085828010069 NA NA NA hsa-miR-320b PIK3R1 1.11183660885284 0.000497971211648503 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.162259703959997 0.00544641812773208 NA NA NA hsa-miR-324-3p PIK3R1 1.04940352369965 0.000387716796520961 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.184232658949902 0.00347746569584922 NA NA NA hsa-miR-330-3p PIK3R1 0.798460296022179 0.00746538156533435 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.26440540068663 2.08637052595379e-05 NA NA NA hsa-miR-335-3p PIK3R1 2.5197689063267 2.20084506976733e-09 -1.09428616452248 2.46783518047221e-05 mirMAP -0.148076206465714 0.000495756694433814 NA NA NA hsa-miR-424-5p PIK3R1 1.08509868581983 0.000420473853818268 -1.09428616452248 2.46783518047221e-05 MirTarget -0.287369315123124 1.32105570633977e-06 NA NA NA hsa-miR-429 PIK3R1 1.40182602301928 0.00900426780286475 -1.09428616452248 2.46783518047221e-05 mirMAP;miRNATAP -0.126994249956039 0.00022771493817442 NA NA NA hsa-miR-455-3p PIK3R1 2.29532323519288 1.85675588946527e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.181586331748295 8.05157474846207e-06 NA NA NA hsa-miR-542-3p PIK3R1 0.757649022262991 0.00210575463285599 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda -0.239065351988831 0.0017318237826115 NA NA NA hsa-miR-584-5p PIK3R1 1.68234626630933 0.000166828539264215 -1.09428616452248 2.46783518047221e-05 mirMAP -0.129450210806705 0.00170622715972499 NA NA NA hsa-miR-590-3p PIK3R1 1.11654983899947 0.000160782154924864 -1.09428616452248 2.46783518047221e-05 miRanda;mirMAP -0.266046553887174 1.8351581859886e-05 NA NA NA hsa-miR-590-5p PIK3R1 1.04171442093217 0.000272475544954865 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda;miRNATAP -0.297910761408884 3.33366270664506e-06 NA NA NA hsa-miR-629-3p PIK3R1 1.40326397107309 9.7803063526732e-05 -1.09428616452248 2.46783518047221e-05 MirTarget -0.16619442916244 0.00118253063445621 NA NA NA hsa-miR-96-5p PIK3R1 1.14243043653372 0.00942969392739105 -1.09428616452248 2.46783518047221e-05 TargetScan;miRNATAP -0.193630203103858 1.00718533638407e-05 NA NA NA hsa-miR-30a-5p PIK3R2 -1.71922855140016 3.20574349285256e-07 0.00922907299312037 0.961081205853821 miRNATAP -0.137164224996737 0.000346855164996688 NA NA NA hsa-miR-1271-5p PIK3R3 1.15538250415776 0.00207865862606828 -0.662491536689023 0.0210304127874503 mirMAP -0.197799197361284 0.00028487328401707 NA NA NA hsa-miR-185-3p PIK3R3 1.33711019171256 3.45756583967985e-05 -0.662491536689023 0.0210304127874503 MirTarget -0.200301326896551 0.00130353125166929 NA NA NA hsa-miR-511-5p PIK3R3 0.542335183701817 0.127507740178883 -0.662491536689023 0.0210304127874503 MirTarget -0.231823970894027 4.82261601939889e-05 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-708-3p PIK3R3 0.623782703831307 0.275355868302311 -0.662491536689023 0.0210304127874503 mirMAP -0.147502347303041 2.93933869168246e-05 NA NA NA hsa-miR-182-5p PIK3R5 0.887369486030646 0.0310640781418789 -0.106061319644644 0.802628610118832 MirTarget -0.363007599134275 3.56264538888151e-07 NA NA NA hsa-miR-18a-3p PIK3R5 2.35188582849667 1.39401350286321e-08 -0.106061319644644 0.802628610118832 MirTarget -0.215221108190999 0.00210782353217643 NA NA NA hsa-miR-127-3p PKN2 0.211466568760589 0.46101284760949 0.111507698649972 0.476419101886784 MirTarget;miRanda -0.123217704910713 0.00141992660564345 NA NA NA hsa-miR-218-5p PKN2 -0.987730614742492 0.0108295837207062 0.111507698649972 0.476419101886784 MirTarget -0.129545334328913 3.06447629221656e-06 NA NA NA hsa-miR-27b-3p PKN2 0.0836323965901755 0.725273923274 0.111507698649972 0.476419101886784 miRNATAP -0.147840429234653 0.00162135868773933 NA NA NA hsa-miR-193b-3p PKN3 0.281752012268679 0.451258902263119 0.53056908049373 0.0429238391961945 miRNAWalker2_validate -0.209794741123841 2.16767675777467e-05 NA NA NA hsa-miR-125a-5p PPP2CA -0.878090699011564 0.000213630844319685 0.107480872641697 0.465806526802027 miRanda -0.114553295277737 0.00863062624749295 NA NA NA hsa-miR-29b-2-5p PPP2CA -1.7015307882027 2.84239251703401e-10 0.107480872641697 0.465806526802027 MirTarget -0.167053730308545 4.03703216535852e-06 NA NA NA hsa-miR-30a-5p PPP2CA -1.71922855140016 3.20574349285256e-07 0.107480872641697 0.465806526802027 mirMAP -0.106261777400481 0.000351504273062397 NA NA NA hsa-miR-30c-5p PPP2CA -0.983130268805942 4.60419218706127e-05 0.107480872641697 0.465806526802027 mirMAP -0.161256288873208 0.000136064658332901 NA NA NA hsa-miR-362-5p PPP2CA -0.354508685915981 0.354912078595613 0.107480872641697 0.465806526802027 TargetScan -0.108020662373963 5.45175893302357e-05 NA NA NA hsa-miR-7-1-3p PPP2CA 0.709309110750947 0.0412301737463194 0.107480872641697 0.465806526802027 mirMAP -0.107071670444797 0.000292904076066977 NA NA NA hsa-miR-199a-5p PPP2R1A 0.371973504507027 0.232661597228763 0.14708086066668 0.243477712111288 miRanda -0.114770859181242 4.51006863190664e-05 NA NA NA hsa-miR-199b-5p PPP2R1A 0.124595928096068 0.678156859366405 0.14708086066668 0.243477712111288 miRanda -0.103378943853271 0.000445497151882613 NA NA NA hsa-miR-107 PPP2R2B 0.904627575346218 4.67936495073904e-05 -1.3848126684449 0.0554407143297931 miRanda -0.881242719933643 0.000126451671605244 NA NA NA hsa-miR-10a-3p PPP2R2B 0.221754213874695 0.560576719784617 -1.3848126684449 0.0554407143297931 mirMAP -0.46590236767074 0.000789996723160265 NA NA NA hsa-miR-141-3p PPP2R2B 1.45548825076434 0.00115958850961764 -1.3848126684449 0.0554407143297931 TargetScan -0.318798973090571 0.00511860905441799 NA NA NA hsa-miR-7-1-3p PPP2R2B 0.709309110750947 0.0412301737463194 -1.3848126684449 0.0554407143297931 mirMAP -0.706851932309068 1.2127865011212e-06 NA NA NA hsa-miR-939-5p PPP2R2B 0.857156740351386 0.0124815824643173 -1.3848126684449 0.0554407143297931 MirTarget -0.4493190221977 0.0064643062846425 NA NA NA hsa-miR-10a-3p PPP2R2C 0.221754213874695 0.560576719784617 1.02451824111908 0.395893091124292 mirMAP -0.946858095708182 3.60912842273225e-05 NA NA NA hsa-miR-148b-5p PPP2R2C 1.04409494910362 0.00195860954157389 1.02451824111908 0.395893091124292 mirMAP -0.822394723533385 0.00111145552530622 NA NA NA hsa-miR-192-5p PPP2R2C 0.0809146624034405 0.941057093528709 1.02451824111908 0.395893091124292 mirMAP -0.708176321025325 2.06966046175514e-24 NA NA NA hsa-miR-194-5p PPP2R2C -0.127742909829168 0.906065815804667 1.02451824111908 0.395893091124292 miRNATAP -0.723575440173531 4.54685564985729e-25 NA NA NA hsa-miR-200b-3p PPP2R2C 0.974577911407732 0.0595020056914543 1.02451824111908 0.395893091124292 TargetScan -0.510159719900787 0.00198489425630945 NA NA NA hsa-miR-500a-3p PPP2R2C 0.133193057420744 0.668896091969871 1.02451824111908 0.395893091124292 MirTarget -0.99472150817674 0.000314223961166972 NA NA NA hsa-miR-501-3p PPP2R2C 0.731876211669996 0.0270421347018303 1.02451824111908 0.395893091124292 MirTarget;PITA;TargetScan;miRNATAP -0.836830265997514 0.00121332256212682 NA NA NA hsa-miR-502-3p PPP2R2C -0.16442685491191 0.557471818466728 1.02451824111908 0.395893091124292 MirTarget;PITA;miRNATAP -1.51802501856502 5.36029253290157e-07 NA NA NA hsa-miR-625-5p PPP2R2C 0.537211086526376 0.203801009380384 1.02451824111908 0.395893091124292 MirTarget -1.45420667074092 3.53918596162486e-14 NA NA NA hsa-miR-106b-5p PPP2R3A 1.70863907461894 2.04074794107142e-08 -1.68813566928309 0.000475819000439266 mirMAP -0.346724340498392 0.00171139299669626 NA NA NA hsa-miR-140-5p PPP2R3A 0.208193069681326 0.303002433893804 -1.68813566928309 0.000475819000439266 PITA;miRanda;miRNATAP -0.50503989729163 0.00422557077576954 NA NA NA hsa-miR-148b-3p PPP2R3A 0.295175884456199 0.17466422420702 -1.68813566928309 0.000475819000439266 miRNAWalker2_validate -0.644491119224473 6.68062515771666e-05 NA NA NA hsa-miR-17-5p PPP2R3A 1.65862087862483 8.45603406215941e-08 -1.68813566928309 0.000475819000439266 mirMAP -0.407114697432337 0.000175984701139812 NA NA NA hsa-miR-181a-5p PPP2R3A 1.39227281909646 1.91689469974826e-09 -1.68813566928309 0.000475819000439266 MirTarget -0.396141535838533 0.00671630187363644 NA NA NA hsa-miR-181b-5p PPP2R3A 1.64216500592669 1.89228845300725e-08 -1.68813566928309 0.000475819000439266 MirTarget -0.390717001399992 0.000690921535200625 NA NA NA hsa-miR-186-5p PPP2R3A 0.149964130725901 0.434709542998771 -1.68813566928309 0.000475819000439266 MirTarget;mirMAP -0.630558480643011 0.000689430251302291 NA NA NA hsa-miR-20a-5p PPP2R3A 1.4503375861709 5.7813456424762e-07 -1.68813566928309 0.000475819000439266 mirMAP -0.454727264619979 9.30941828075875e-05 NA NA NA hsa-miR-30b-3p PPP2R3A -0.266398938200332 0.400847813143994 -1.68813566928309 0.000475819000439266 MirTarget -0.463214312582692 2.22403065144451e-05 NA NA NA hsa-miR-320a PPP2R3A 0.593888711838028 0.011897419390526 -1.68813566928309 0.000475819000439266 miRanda -0.497812393417452 0.000787324763484161 NA NA NA hsa-miR-320b PPP2R3A 1.11183660885284 0.000497971211648503 -1.68813566928309 0.000475819000439266 miRanda -0.408382052535203 0.000142045688614803 NA NA NA hsa-miR-34a-5p PPP2R3A 0.794251341270032 0.00024017386701179 -1.68813566928309 0.000475819000439266 MirTarget;miRNATAP -0.717940208143361 6.47390756482137e-06 NA NA NA hsa-miR-3614-5p PPP2R3A 1.10426689932954 0.00706308396674599 -1.68813566928309 0.000475819000439266 MirTarget -0.45169512132782 5.88679423962969e-08 NA NA NA hsa-miR-375 PPP2R3A -2.94506033785642 0.00570147601654791 -1.68813566928309 0.000475819000439266 miRanda -0.19563837795566 2.82179734139556e-10 NA NA NA hsa-miR-429 PPP2R3A 1.40182602301928 0.00900426780286475 -1.68813566928309 0.000475819000439266 miRanda -0.298208987991166 2.36892248371662e-06 NA NA NA hsa-miR-502-5p PPP2R3A -0.260297419808178 0.520453580478988 -1.68813566928309 0.000475819000439266 miRNATAP -0.254607446565396 0.0033884240432993 NA NA NA hsa-miR-577 PPP2R3A 0.911619788986754 0.2256062124148 -1.68813566928309 0.000475819000439266 MirTarget -0.328651619113365 1.73163437711134e-13 NA NA NA hsa-miR-589-5p PPP2R3A 0.702695092403762 0.00395772685954799 -1.68813566928309 0.000475819000439266 MirTarget -0.578402741224747 4.65832646465738e-05 NA NA NA hsa-miR-376b-3p PPP2R5A 0.732975685259383 0.0626789991508105 -0.591079622253316 0.00119145100954947 MirTarget -0.116320148112935 0.000559750129098542 NA NA NA hsa-miR-376c-3p PPP2R5A -0.0202687695094781 0.953448994947367 -0.591079622253316 0.00119145100954947 MirTarget -0.103893654322188 0.00605996677969449 NA NA NA hsa-miR-484 PPP2R5A 0.71327898984355 0.00233605130771196 -0.591079622253316 0.00119145100954947 miRNAWalker2_validate -0.148670128543476 0.00788807707272385 NA NA NA hsa-miR-107 PPP2R5C 0.904627575346218 4.67936495073904e-05 -0.176772832503885 0.203679171150841 PITA;miRanda;miRNATAP -0.188095657073649 1.34053011674783e-05 NA NA NA hsa-miR-140-3p PPP2R5C -0.296251775392129 0.127539826012144 -0.176772832503885 0.203679171150841 MirTarget -0.205173208832184 5.52419606834808e-05 NA NA NA hsa-miR-15b-5p PPP2R5C 1.62046407540723 5.42152621571078e-09 -0.176772832503885 0.203679171150841 miRNATAP -0.119606390298285 0.000400965301531017 NA NA NA hsa-miR-16-5p PPP2R5C 1.00515772948091 5.33912942007619e-06 -0.176772832503885 0.203679171150841 miRNAWalker2_validate;miRNATAP -0.156504313535812 0.000329654257799899 NA NA NA hsa-miR-186-5p PPP2R5C 0.149964130725901 0.434709542998771 -0.176772832503885 0.203679171150841 mirMAP;miRNATAP -0.232717239095693 5.9930383494795e-06 NA NA NA hsa-miR-26a-5p PPP2R5C -0.384110714440647 0.0442498636014044 -0.176772832503885 0.203679171150841 mirMAP -0.183987481147365 0.00040267955241603 NA NA NA hsa-miR-26b-5p PPP2R5C -0.301646326928219 0.160081421968103 -0.176772832503885 0.203679171150841 mirMAP -0.12747361396581 0.00593728156245827 NA NA NA hsa-miR-335-5p PPP2R5C 1.59953351087307 5.56170899867314e-05 -0.176772832503885 0.203679171150841 MirTarget -0.113494499488103 1.67005545254136e-06 NA NA NA hsa-miR-101-5p PPP2R5E -0.567139223563276 0.0306291767849722 0.235737250416584 0.136582975257671 MirTarget -0.192884215444308 4.96216146559148e-06 NA NA NA hsa-miR-126-5p PPP2R5E 0.41765430251855 0.0753161203651532 0.235737250416584 0.136582975257671 MirTarget;mirMAP -0.166247578287667 0.000518230130809856 NA NA NA hsa-miR-139-5p PPP2R5E -1.83374360776637 1.22019901002824e-09 0.235737250416584 0.136582975257671 miRanda -0.101023223743176 0.00452060978756835 NA NA NA hsa-miR-148a-5p PPP2R5E -0.69329616490858 0.0793012233740369 0.235737250416584 0.136582975257671 MirTarget -0.134117721971487 1.2466790765875e-06 NA NA NA hsa-miR-181c-5p PPP2R5E 0.336826967681288 0.112932307913601 0.235737250416584 0.136582975257671 MirTarget;mirMAP -0.184993610646681 0.00051064527058061 NA NA NA hsa-miR-29b-2-5p PPP2R5E -1.7015307882027 2.84239251703401e-10 0.235737250416584 0.136582975257671 mirMAP -0.171505972467459 1.21916104784881e-05 NA NA NA hsa-miR-30b-5p PPP2R5E -0.430720743745757 0.0593564057320791 0.235737250416584 0.136582975257671 mirMAP -0.21087009022014 1.58880493426893e-05 NA NA NA hsa-miR-30c-5p PPP2R5E -0.983130268805942 4.60419218706127e-05 0.235737250416584 0.136582975257671 mirMAP -0.152665457232651 0.000859767000912167 NA NA NA hsa-miR-30d-3p PPP2R5E -0.545113326540761 0.0433733076874155 0.235737250416584 0.136582975257671 MirTarget -0.167013061173456 4.98940528702363e-05 NA NA NA hsa-miR-30d-5p PPP2R5E -0.5492586056147 0.0140125082460125 0.235737250416584 0.136582975257671 mirMAP -0.168983918407369 0.000777485622974453 NA NA NA hsa-miR-30e-3p PPP2R5E -0.913131357083321 7.29096855615228e-06 0.235737250416584 0.136582975257671 MirTarget -0.231206225508213 1.83759723629195e-05 NA NA NA hsa-miR-30e-5p PPP2R5E -0.573784818166736 0.0112497802572927 0.235737250416584 0.136582975257671 mirMAP -0.138976502622496 0.00528643241281768 NA NA NA hsa-miR-326 PPP2R5E -0.429748586406214 0.2629894124021 0.235737250416584 0.136582975257671 miRanda -0.119121233816166 4.28678411973928e-05 NA NA NA hsa-miR-374a-3p PPP2R5E 0.0420912023953779 0.851478041312794 0.235737250416584 0.136582975257671 MirTarget -0.138165976402987 0.00636241183675181 NA NA NA hsa-miR-374a-5p PPP2R5E -0.116485410477589 0.554703396010082 0.235737250416584 0.136582975257671 mirMAP -0.173546808962474 0.00277858623655472 NA NA NA hsa-miR-502-3p PPP2R5E -0.16442685491191 0.557471818466728 0.235737250416584 0.136582975257671 MirTarget;PITA;miRNATAP -0.174272297090979 1.0998313575864e-05 NA NA NA hsa-miR-7-1-3p PPP2R5E 0.709309110750947 0.0412301737463194 0.235737250416584 0.136582975257671 MirTarget;mirMAP -0.118060282773657 0.000212421568775288 NA NA NA hsa-miR-130a-3p PRKAA1 0.146223920674657 0.633739795905839 -0.11031844984051 0.603484784278822 MirTarget;miRNATAP -0.149554065669798 0.00237515644979475 NA NA NA hsa-miR-146b-3p PRKAA1 1.10138643500522 3.66835580263893e-05 -0.11031844984051 0.603484784278822 MirTarget;PITA;miRNATAP -0.159880575940438 0.0040852630528234 NA NA NA hsa-miR-152-3p PRKAA1 0.436002345388935 0.161701199884702 -0.11031844984051 0.603484784278822 MirTarget -0.188594057880005 8.42182092122934e-05 NA NA NA hsa-miR-224-3p PRKAA1 1.52422171450716 0.00650463542340912 -0.11031844984051 0.603484784278822 MirTarget -0.107509894610809 0.000196654827670158 NA NA NA hsa-miR-769-5p PRKAA1 1.14821899306381 1.27143750879772e-06 -0.11031844984051 0.603484784278822 MirTarget;PITA -0.256209603953874 3.30523424266437e-05 NA NA NA hsa-let-7d-5p PRKAA2 0.981733854788227 7.26366577706469e-07 -3.71133264004618 3.9299607177825e-05 MirTarget -1.20061764900106 0.000235472800470893 NA NA NA hsa-let-7f-1-3p PRKAA2 1.28704406797397 1.17954701106157e-06 -3.71133264004618 3.9299607177825e-05 mirMAP -1.12161744228138 2.63421941652295e-06 NA NA NA hsa-miR-106b-5p PRKAA2 1.70863907461894 2.04074794107142e-08 -3.71133264004618 3.9299607177825e-05 mirMAP -0.590927081903682 0.00458457271848234 NA NA NA hsa-miR-130b-3p PRKAA2 1.32714007211004 4.78676252285191e-05 -3.71133264004618 3.9299607177825e-05 MirTarget -0.636862993307953 0.00125092207613592 NA NA NA hsa-miR-142-5p PRKAA2 1.55592486377018 6.69269968016779e-06 -3.71133264004618 3.9299607177825e-05 mirMAP -0.484634735754829 0.0092541578176505 NA NA NA hsa-miR-146a-5p PRKAA2 1.82051649415508 2.03651725047679e-05 -3.71133264004618 3.9299607177825e-05 MirTarget -0.463601412715785 0.0019909428683854 NA NA NA hsa-miR-15b-3p PRKAA2 1.75738933306437 3.00554466232543e-08 -3.71133264004618 3.9299607177825e-05 mirMAP -0.613642846589506 0.00214003644966405 NA NA NA hsa-miR-16-2-3p PRKAA2 1.8048179609245 2.83095715136409e-09 -3.71133264004618 3.9299607177825e-05 mirMAP -0.725490763387464 0.000454424919074799 NA NA NA hsa-miR-17-5p PRKAA2 1.65862087862483 8.45603406215941e-08 -3.71133264004618 3.9299607177825e-05 mirMAP -0.727347652973957 0.000376279663801 NA NA NA hsa-miR-192-5p PRKAA2 0.0809146624034405 0.941057093528709 -3.71133264004618 3.9299607177825e-05 miRNAWalker2_validate -0.263647438903586 7.30199851190626e-06 NA NA NA hsa-miR-19a-3p PRKAA2 1.26669687448473 0.000105972838514412 -3.71133264004618 3.9299607177825e-05 mirMAP -0.616671439740848 0.00181244727354879 NA NA NA hsa-miR-20a-5p PRKAA2 1.4503375861709 5.7813456424762e-07 -3.71133264004618 3.9299607177825e-05 mirMAP -0.742762614304113 0.000734108936016583 NA NA NA hsa-miR-21-3p PRKAA2 1.75245546017565 2.36505176715025e-10 -3.71133264004618 3.9299607177825e-05 mirMAP -0.916372354505537 4.71091423087025e-05 NA NA NA hsa-miR-31-5p PRKAA2 0.666358292391859 0.381800494600846 -3.71133264004618 3.9299607177825e-05 MirTarget -0.254933092386802 0.00482998804925364 NA NA NA hsa-miR-323b-3p PRKAA2 1.13581624461921 0.0214847831286342 -3.71133264004618 3.9299607177825e-05 mirMAP -0.385332397863294 0.00992531661617914 NA NA NA hsa-miR-335-3p PRKAA2 2.5197689063267 2.20084506976733e-09 -3.71133264004618 3.9299607177825e-05 MirTarget -0.588326292668759 6.72977735836248e-05 NA NA NA hsa-miR-454-3p PRKAA2 0.625199142970745 0.0134890997402741 -3.71133264004618 3.9299607177825e-05 MirTarget -0.675421456170318 0.00970280004126242 NA NA NA hsa-miR-577 PRKAA2 0.911619788986754 0.2256062124148 -3.71133264004618 3.9299607177825e-05 MirTarget;PITA;miRNATAP -0.312455257440675 0.000411707891810278 NA NA NA hsa-miR-589-5p PRKAA2 0.702695092403762 0.00395772685954799 -3.71133264004618 3.9299607177825e-05 MirTarget -1.03409607920384 0.000112480768745506 NA NA NA hsa-miR-7-1-3p PRKAA2 0.709309110750947 0.0412301737463194 -3.71133264004618 3.9299607177825e-05 MirTarget;mirMAP -0.633679071955952 0.000743449889302512 NA NA NA hsa-miR-183-5p PRKCA 1.65900927871187 0.000522025364980187 -0.524945602243661 0.156845722980603 miRNATAP -0.31103089433757 3.16968192454963e-09 NA NA NA hsa-miR-193b-3p PRKCA 0.281752012268679 0.451258902263119 -0.524945602243661 0.156845722980603 miRNAWalker2_validate -0.484019253003446 4.65153076194767e-13 NA NA NA hsa-miR-193b-5p PRKCA 0.609581100028941 0.13923921336815 -0.524945602243661 0.156845722980603 mirMAP -0.433727503937308 7.91160654871288e-13 NA NA NA hsa-miR-200c-3p PRKCA 1.28185685499076 0.00369777635539177 -0.524945602243661 0.156845722980603 miRNATAP -0.158267946470227 0.0075664310799573 NA NA NA hsa-miR-214-3p PRKCA 1.01201534142544 0.00625092909225755 -0.524945602243661 0.156845722980603 mirMAP -0.229516662046359 0.00116026469450838 NA NA NA hsa-miR-218-5p PRKCA -0.987730614742492 0.0108295837207062 -0.524945602243661 0.156845722980603 mirMAP -0.340197633280215 2.69227593052796e-07 NA NA NA hsa-miR-22-5p PRKCA 0.804348748654247 0.000804065112767412 -0.524945602243661 0.156845722980603 mirMAP -0.289814182834915 0.0085643888637562 NA NA NA hsa-miR-224-5p PRKCA 2.7648036144402 0.000111736336240167 -0.524945602243661 0.156845722980603 mirMAP -0.266077095767105 2.93934461700145e-15 NA NA NA hsa-miR-2355-3p PRKCA 0.982963823342009 0.0229275810851348 -0.524945602243661 0.156845722980603 mirMAP -0.192620283882863 0.00177074877059007 NA NA NA hsa-miR-24-2-5p PRKCA 1.24948624677556 6.95051249640114e-07 -0.524945602243661 0.156845722980603 miRNAWalker2_validate -0.44305928315788 1.26846671995315e-05 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-3065-5p PRKCA -0.241623656423063 0.633116553078159 -0.524945602243661 0.156845722980603 mirMAP -0.138739209322651 0.00952332540419745 NA NA NA hsa-miR-30e-3p PRKCA -0.913131357083321 7.29096855615228e-06 -0.524945602243661 0.156845722980603 mirMAP -0.480631092157774 0.000179519199509064 NA NA NA hsa-miR-340-5p PRKCA -0.164941927483643 0.529910509321278 -0.524945602243661 0.156845722980603 mirMAP -0.30203863377261 0.00294907401860914 NA NA NA hsa-miR-369-3p PRKCA 0.32261175629684 0.3589927609891 -0.524945602243661 0.156845722980603 PITA;miRNATAP -0.329749662436249 8.7729830203155e-06 NA NA NA hsa-miR-374a-3p PRKCA 0.0420912023953779 0.851478041312794 -0.524945602243661 0.156845722980603 mirMAP -0.476867699823759 5.6043349916606e-05 NA NA NA hsa-miR-374a-5p PRKCA -0.116485410477589 0.554703396010082 -0.524945602243661 0.156845722980603 mirMAP -0.356017213117889 0.00964742858084568 NA NA NA hsa-miR-381-3p PRKCA -0.385137659444633 0.19550293487428 -0.524945602243661 0.156845722980603 mirMAP -0.251195477739459 0.00489691969707007 NA NA NA hsa-miR-452-5p PRKCA 2.08756506185889 0.000258095769002813 -0.524945602243661 0.156845722980603 mirMAP -0.362021740586027 3.81652270570704e-18 NA NA NA hsa-miR-485-3p PRKCA 0.402652239390796 0.291980476362068 -0.524945602243661 0.156845722980603 PITA -0.187072641608852 0.00755799449285324 NA NA NA hsa-miR-590-3p PRKCA 1.11654983899947 0.000160782154924864 -0.524945602243661 0.156845722980603 PITA;miRanda;mirMAP;miRNATAP -0.253263144251919 0.0041311394662334 NA NA NA hsa-miR-654-3p PRKCA -0.180620884059292 0.603937505298333 -0.524945602243661 0.156845722980603 mirMAP -0.244452048619274 0.00127970540235088 NA NA NA hsa-miR-9-3p PRKCA 0.330346058941473 0.541111939982661 -0.524945602243661 0.156845722980603 mirMAP -0.16554523182915 0.00109100333735947 NA NA NA hsa-miR-9-5p PRKCA -0.195328736653048 0.761470692992178 -0.524945602243661 0.156845722980603 miRNATAP -0.159066735795387 8.70395397790985e-05 NA NA NA hsa-miR-93-3p PRKCA 1.88964231421793 1.80075645722786e-08 -0.524945602243661 0.156845722980603 mirMAP -0.204378358847077 0.00717568024324572 NA NA NA hsa-miR-944 PRKCA 3.33123095809751 0.0177835044930391 -0.524945602243661 0.156845722980603 PITA;miRNATAP -0.18876945085729 3.75302733857894e-21 NA NA NA hsa-let-7i-5p PRLR 0.798954594465461 2.99735653959449e-05 -1.89609622376219 0.0101234287959838 miRNATAP -0.855407120682147 0.0020143856121384 NA NA NA hsa-miR-218-5p PRLR -0.987730614742492 0.0108295837207062 -1.89609622376219 0.0101234287959838 miRNATAP -0.406480604406767 0.0027019181607033 NA NA NA hsa-miR-34c-5p PRLR 2.20632574870337 0.000379662996168678 -1.89609622376219 0.0101234287959838 miRanda;miRNATAP -0.448293175794544 4.58046531826808e-08 NA NA NA hsa-miR-944 PRLR 3.33123095809751 0.0177835044930391 -1.89609622376219 0.0101234287959838 mirMAP -0.247865381017898 7.64517683238236e-09 NA NA NA hsa-miR-103a-3p PTEN 0.840525139266028 5.83536475789158e-07 -0.439862628350054 0.00288389874110071 miRNAWalker2_validate;miRTarBase -0.257442252482047 3.11707848254512e-05 26511107;24828205 LncRNA GAS5 induces PTEN expression through inhibiting miR 103 in endometrial cancer cells; To investigate the expression of GAS5 PTEN and miR-103 RT-PCR was performed; Finally we found that miR-103 mimic could decrease the mRNA and protein levels of PTEN through luciferase reporter assay and western blotting and GAS5 plasmid may reverse this regulation effect in endometrial cancer cells; Through inhibiting the expression of miR-103 GAS5 significantly enhanced the expression of PTEN to promote cancer cell apoptosis and thus could be an important mediator in the pathogenesis of endometrial cancer;Our data collectively demonstrate that miR-103 is an oncogene miRNA that promotes colorectal cancer proliferation and migration through down-regulation of the tumor suppressor genes DICER and PTEN ; endometrial cancer;colorectal cancer hsa-miR-106b-5p PTEN 1.70863907461894 2.04074794107142e-08 -0.439862628350054 0.00288389874110071 miRNAWalker2_validate;miRTarBase;miRNATAP -0.119092505372708 0.000319006222689429 24842611;26238857;26722252 MicroRNA 106b in cancer associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN;We further identified PTEN and p21 as novel direct targets of miR-106b by using target prediction algorithms and a luciferase assay; Overexpression of miR-106b reduced the expression of PTEN and p21 and increased the expression of p-AKT which is a downstream of PTEN; Restoring the expression of PTEN or p21 in stably miR-106b-overexpressed cells could rescue the effect of miR-106b on cell radioresistance; These observations illustrated that miR-106b could induce cell radioresistance by directly targeting PTEN and p21 this process was accompanied by tumour-initiating cell capacity enhancement which is universally confirmed to be associated with radioresistance;Cantharidin modulates the E2F1/MCM7 miR 106b 93/p21 PTEN signaling axis in MCF 7 breast cancer cells cell migration;drug resistance; gastric cancer;colorectal cancer;breast cancer hsa-miR-16-1-3p PTEN 1.43227522002564 3.70920454953168e-08 -0.439862628350054 0.00288389874110071 MirTarget -0.117398669841475 0.0027231630162008 NA NA NA hsa-miR-17-5p PTEN 1.65862087862483 8.45603406215941e-08 -0.439862628350054 0.00288389874110071 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.124323874557627 0.000136392655221086 27400681;23391506;23133552;26629823;24462867;26318586;26215320;25634356;26500892;24912422;23418359 GFRα2 prompts cell growth and chemoresistance through down regulating tumor suppressor gene PTEN via Mir 17 5p in pancreatic cancer; Mechanically we discovered that high GFRα2 expression level leads to PTEN inactivation via enhancing Mir-17-5p level;We found that these phenotypes were the results of miR-17 targeting PTEN;PTEN mRNA correlated inversely with miR-92a and members of the miR-17 and miR-130/301 families;We hypothesized that knocking down the oncogenic microRNA oncomiR miR-17-5p might restore the expression levels of PDCD4 and PTEN tumor suppressor proteins illustrating a route to oligonucleotide therapy of TNBC; Contrary to conventional wisdom antisense knockdown of oncomiR miR-17-5p guide strand reduced PDCD4 and PTEN proteins by 1.8±0.3 fold in human TNBC cells instead of raising them; Bioinformatics analysis and folding energy calculations revealed that mRNA targets of miR-17-5p guide strand such as PDCD4 and PTEN could also be regulated by miR-17-3p passenger strand;miR 17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression; Expression of miR-17 was negatively correlated with PTEN in OS tissues;Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR 17 family in prostate cancer; Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo;In addition ERβ expression significantly increased in calycosin-treated HCT-116 cells followed by a decrease of miR-17 and up-regulation of PTEN; Our results indicate that calycosin has an inhibitory effect on CRC which might be obtained by ERβ-mediated regulation of miR-17 and PTEN expression;The High Expression of the microRNA 17 92 Cluster and its Paralogs and the Downregulation of the Target Gene PTEN Is Associated with Primary Cutaneous B Cell Lymphoma Progression;MicroRNA 17 5p induces drug resistance and invasion of ovarian carcinoma cells by targeting PTEN signaling; miR-17-5p activates AKT by downregulation of PTEN in ovarian cancer cells;MicroRNA 17 5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression; We found that PTEN was a target of miR-17-5p in the colon cancer cells and their context-specific interactions were responsible for multiple drug-resistance; Chemotherapy was found to increase the expression levels of miR-17-5p which further repressed PTEN levels contributing to the development of chemo-resistance; MiR-17-5p is a predictive factor for chemotherapy response and a prognostic factor for overall survival in CRC which is due to its regulation of PTEN expression;The mature miR-17-5p exerted this function by repressing the expression of PTEN drug resistance;;;;metastasis;;;progression;drug resistance;metastasis;drug resistance;poor survival; pancreatic cancer;glioblastoma;sarcoma;breast cancer;sarcoma;prostate cancer;colorectal cancer;B cell lymphoma;ovarian cancer;colorectal cancer;liver cancer hsa-miR-181c-5p PTEN 0.336826967681288 0.112932307913601 -0.439862628350054 0.00288389874110071 MirTarget;miRNATAP -0.152032634623252 0.00243414632288238 25695913 miR 181c promotes proliferation via suppressing PTEN expression in inflammatory breast cancer; In this study we showed that miR-181c as an oncogene promoted proliferation and it inhibited PTEN protein expression by targeting 3'-UTR of PTEN mRNA in IBC SUM149 cells; Thus targeting miR-181c and restoration of PTEN can be used in conjunction with other therapies to prevent progression of IBC progression breast cancer hsa-miR-181d-5p PTEN 0.65192727601808 0.0143398117228333 -0.439862628350054 0.00288389874110071 MirTarget -0.119382928028224 0.00248265906348588 27006767 Moreover hsa-miR-181d was upregulated to control expression a tumor suppressor gene PTEN to protect the cancer cell from apoptosis endometrial cancer hsa-miR-186-5p PTEN 0.149964130725901 0.434709542998771 -0.439862628350054 0.00288389874110071 mirMAP;miRNATAP -0.152167020094511 0.0067096432586269 NA NA NA hsa-miR-18a-5p PTEN 2.20211504140984 1.78678887916334e-09 -0.439862628350054 0.00288389874110071 miRNAWalker2_validate;miRTarBase -0.100407705340982 0.000229468335660971 27291152;24681249 miR 18a promotes cell proliferation of esophageal squamous cell carcinoma cells by increasing cylin D1 via regulating PTEN PI3K AKT mTOR signaling axis;However higher levels of the miR-17~92 cluster switched from PTEN to oncogenes including Ctnnb1 β-catenin via miR-18a which resulted in inhibition of tumor growth and metastasis ;metastasis esophageal cancer;colon cancer hsa-miR-20a-5p PTEN 1.4503375861709 5.7813456424762e-07 -0.439862628350054 0.00288389874110071 miRNAWalker2_validate;miRTarBase;miRNATAP -0.125575661981392 0.000343330739702887 26031366 The expression of miR-20a and PTEN were detected in HCC cell lines and paired primary tissues by quantitative real-time polymerase chain reaction; MiR-20a levels were increased in HCC cell lines and tissues whereas PTEN was inversely correlated with it; PTEN was identified as a direct functional target of miR-20a for the induction of radioresistance drug resistance liver cancer hsa-miR-222-3p PTEN 1.39382731585819 9.98182478024671e-07 -0.439862628350054 0.00288389874110071 miRNAWalker2_validate;miRTarBase -0.108079296157776 0.00265168006762418 27746366;23994196;24895988;20618998;26535064;23974492;27699665;27566197 Moreover upregulation of miR-222 expression in MCF-7/S cells is associated with decreased PTEN expression levels and increased phospho-Akt p-Akt expression; Conversely in MCF-7/ADR cells inhibition of miR-222 resulted in increased PTEN expression and decreased p-Akt expression;Western blot results suggested that miR-222 and -29a could regulate the expression of PTEN maybe through which the two miRNAs conferred Adr and Doc resistance in MCF-7 cells; The most importance is that we identify two miRNAs miR-222 and miR-29a involved in drug-resistance at least in part via targeting PTEN;The reduced the expression of PTEN and p27 by miR-222 in HeLa cells and SiHa cells was associated with increased proliferation and migration of CC cells; MiR-222 plays an important role in the tumorigenesis of CC possibly by specifically down-regulating p27Kip1 and PTEN;MicroRNA 221 and microRNA 222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN; PTEN-3'UTR luciferase reporter assay confirmed PTEN as a direct target of miR-221 and miR-222; These results demonstrate that miR-221 and miR-222 regulate radiosensitivity and cell growth and invasion of SGC7901 cells possibly via direct modulation of PTEN expression;MiR-222 and putative target gene expression levels including p27 p57 and PTEN were determined using quantitative reverse transcription polymerase chain reactions and Western blotting; Further we found p57 at protein level but not p27 nor PTEN was regulated by miR-222 in Capan-2 cells;MiR-222 induces cell growth and cell cycle progression via direct targeting of p27 p57 and PTEN in cancer cells;The results showed that inhibition of miR-222 in MCF-7/Adr significantly increased the expressions of PTEN and p27 kip1 and decreased phospho-Akt p-Akt both in mRNA and protein levels p < 0.05 by using quantitative real-time PCR qRT-PCR and western blot; Conversely in MCF-7/S transfected with miR-222 mimics upregulation of miR-222 is associated with decreasing PTEN and p27 kip1 and increasing Akt accompanied by less apoptosis and higher IC50;The expression of tumor suppressor p27 and PTEN miR-222 target genes was significantly increased by PNS treatment ;drug resistance;tumorigenesis;drug resistance;;progression;; breast cancer;breast cancer;cervical and endocervical cancer;gastric cancer;pancreatic cancer;lung cancer;breast cancer;lung cancer hsa-miR-25-3p PTEN 1.00604871526544 0.000421838061147906 -0.439862628350054 0.00288389874110071 miRTarBase;MirTarget;miRNATAP -0.141857747668459 8.68431873420322e-05 NA NA NA hsa-miR-335-3p PTEN 2.5197689063267 2.20084506976733e-09 -0.439862628350054 0.00288389874110071 MirTarget -0.121544500600449 1.68854176574293e-07 NA NA NA hsa-miR-421 PTEN 1.80720854070385 1.59709651202848e-07 -0.439862628350054 0.00288389874110071 miRanda -0.110715787301831 0.000153716455337487 NA NA NA hsa-miR-425-5p PTEN 1.13924952403101 0.000255357546232931 -0.439862628350054 0.00288389874110071 miRNATAP -0.136749196412418 3.2459172510343e-05 25154996 An increase in miR-425 depended upon IL-1β-induced NF-kappaB activation.Repression of PTEN by miR-425 promoted gastric cancer cell proliferation gastric cancer hsa-miR-454-3p PTEN 0.625199142970745 0.0134890997402741 -0.439862628350054 0.00288389874110071 MirTarget;miRNATAP -0.14154447102058 0.000638326410710137 26296312;27261580 MicroRNA 454 functions as an oncogene by regulating PTEN in uveal melanoma; Furthermore we identified PTEN as a direct target of miR-454; Our data revealed that ectopic expression of PTEN restored the effects of miR-454 on cell proliferation and invasion in uveal melanoma cells;MiR 454 promotes the progression of human non small cell lung cancer and directly targets PTEN; At last the potential regulatory function of miR-454 on PTEN expression was confirmed; Further PTEN was confirmed as a direct target of miR-454 by using Luciferase Reporter Assay ;progression melanoma;lung squamous cell cancer hsa-miR-484 PTEN 0.71327898984355 0.00233605130771196 -0.439862628350054 0.00288389874110071 miRNATAP -0.123324186207252 0.00608200697888501 NA NA NA hsa-miR-532-5p PTEN 0.313080805824184 0.252248939356301 -0.439862628350054 0.00288389874110071 PITA;mirMAP;miRNATAP -0.137190125334249 0.00035870173357934 NA NA NA hsa-miR-589-3p PTEN 1.01962606923682 0.00577853347252709 -0.439862628350054 0.00288389874110071 MirTarget;mirMAP -0.108837670957723 9.77792683670741e-05 NA NA NA hsa-miR-590-5p PTEN 1.04171442093217 0.000272475544954865 -0.439862628350054 0.00288389874110071 mirMAP -0.104718214872404 0.00394248736334067 23803188 Targetscan predicted PDCD4 and PTEN as the potential target genes of miR-590-5p and miR-590-3p which was verified by luciferase reporter system and Western blotting liver cancer hsa-miR-7-1-3p PTEN 0.709309110750947 0.0412301737463194 -0.439862628350054 0.00288389874110071 mirMAP -0.123402510670047 3.43125792570084e-05 NA NA NA hsa-miR-92a-3p PTEN 1.2209325870225 6.8757197708107e-06 -0.439862628350054 0.00288389874110071 MirTarget;miRNATAP -0.14277985087479 0.000153445490465264 26432332;25515201;24137349;23546593;23133552;24026406 Downregulation of PTEN could mimic the same effects of miR-92a mimic in NSCLC cells and rescue the effects on NSCLC cells induced by miR-92a inhibitor; Taken together these findings suggested that miR-92a could promote growth metastasis and chemoresistance in NSCLC cells at least partially by targeting PTEN;MiR 92a Promotes Cell Metastasis of Colorectal Cancer Through PTEN Mediated PI3K/AKT Pathway; The expression of miR-92a PTEN and E-cadherin was analyzed by real-time PCR; In addition there was a negative correlation between levels of miR-92a and the PTEN gene p < 0.0001; The association of levels of miR-92a and PTEN with tumor cell migration in CRC was also confirmed in CRC cell models;MicroRNA miR-92 is overexpressed in a number of tumors and has been proven to negatively regulate a number of tumor suppressor genes including phosphatase and tensin homologue PTEN; PTEN protein expression was decreased in the SiHa cells that were transfected with the miR-92 mimic; The data indicated that miR-92 may increase the migration and invasion of SiHa cells partially through the downregulation of PTEN protein expression;Expression and significance of PTEN and miR 92 in hepatocellular carcinoma; Immunohistochemistry streptavidin-peroxidase SP and quantitative reverse transcriptase-polymerase chain reaction qRT‑PCR were used to detect the expression of PTEN and miR-92 in 15 cases of HCC and the corresponding paracancerous tissues; The correlation between PTEN and miR-92 was analyzed; Additionally the mRNA levels of PTEN and miR-92 showed a significantly negative correlation with each other r=-0.858 P<0.05; In conclusion PTEN and miR-92 have different roles in the development of HCC; The combined detection of PTEN and miR-92 may provide critical clinical evidence for the early diagnosis and prognosis of HCC;PTEN mRNA correlated inversely with miR-92a and members of the miR-17 and miR-130/301 families;The expression levels of miR-92a and phosphatase and tensin homologue PTEN were detected by qRT-PCR and western blot; In addition the regulation of PTEN by miR-92a was evaluated by qRT-PCR western blot and luciferase reporter assays; There was an inverse correlation between the levels of miR-92a and PTEN in CRC tissues; The overexpression of miR-92a in CRC cells decreased PTEN expression at the translational level and decreased PTEN-driven luciferase-reporter activity; Our results demonstrated that miR-92a induced EMT and regulated cell growth migration and invasion in the SW480 cells at least partially via suppression of PTEN expression metastasis;drug resistance;metastasis;cell migration;;worse prognosis;; lung squamous cell cancer;colorectal cancer;cervical and endocervical cancer;liver cancer;sarcoma;colorectal cancer hsa-miR-93-5p PTEN 1.7515174434778 1.59386482413883e-08 -0.439862628350054 0.00288389874110071 miRNAWalker2_validate;miRTarBase;miRNATAP -0.149740498224861 3.14876574637166e-06 25633810;26243299;22465665;26087719 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC;microRNA 93 promotes cell proliferation via targeting of PTEN in Osteosarcoma cells; An miRNA miR-93 was significantly up-regulated whereas phosphatase and tensin homologue PTEN expression was significantly down-regulated in all tested OS cells when compared with hMSCs; Ectopic expression of miR-93 decreased PTEN protein levels; Taking these observations together miR-93 can be seen to play a critical role in carcinogenesis through suppression of PTEN and may serve as a therapeutic target for the treatment of OS;Furthermore we found that miR-93 can directly target PTEN and participates in the regulation of the AKT signaling pathway; MiR-93 inversely correlates with PTEN expression in CDDP-resistant and sensitive human ovarian cancer tissues;Furthermore our study found berberine could inhibit miR-93 expression and function in ovarian cancer as shown by an increase of its target PTEN an important tumor suppressor in ovarian cancer; More importantly A2780 cells that were treated with PTEN siRNA had a survival pattern that is similar to cells with miR-93 overexpression ;tumorigenesis;;poor survival liver cancer;sarcoma;ovarian cancer;ovarian cancer hsa-miR-139-5p PTK2 -1.83374360776637 1.22019901002824e-09 0.276089305828771 0.103687124058962 miRanda -0.12481462384513 0.0010434349292379 NA NA NA hsa-miR-140-5p PTK2 0.208193069681326 0.303002433893804 0.276089305828771 0.103687124058962 miRanda -0.217261378925225 0.000315148676816685 NA NA NA hsa-miR-30c-5p RAC1 -0.983130268805942 4.60419218706127e-05 0.63005132289186 0.00013432252267484 miRNAWalker2_validate -0.215519718166738 7.09586530438521e-06 NA NA NA hsa-miR-146b-3p RAF1 1.10138643500522 3.66835580263893e-05 -0.8632101633735 1.53817801108877e-10 MirTarget;PITA;miRNATAP -0.120516156621644 0.00105150756879764 NA NA NA hsa-miR-484 RAF1 0.71327898984355 0.00233605130771196 -0.8632101633735 1.53817801108877e-10 MirTarget -0.121560277635947 0.00438132826235516 NA NA NA hsa-miR-106b-5p RBL2 1.70863907461894 2.04074794107142e-08 -0.554881951006322 0.000774596666255453 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.181136412099074 7.86544607170665e-07 NA NA NA hsa-miR-107 RBL2 0.904627575346218 4.67936495073904e-05 -0.554881951006322 0.000774596666255453 miRanda -0.257137578949083 6.89556080677443e-07 NA NA NA hsa-miR-126-5p RBL2 0.41765430251855 0.0753161203651532 -0.554881951006322 0.000774596666255453 MirTarget -0.162975507515902 0.00129998272063549 NA NA NA hsa-miR-142-5p RBL2 1.55592486377018 6.69269968016779e-06 -0.554881951006322 0.000774596666255453 PITA -0.136782399094381 3.42700164897742e-05 NA NA NA hsa-miR-17-5p RBL2 1.65862087862483 8.45603406215941e-08 -0.554881951006322 0.000774596666255453 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.126609858780632 0.000578098831951693 NA NA NA hsa-miR-335-3p RBL2 2.5197689063267 2.20084506976733e-09 -0.554881951006322 0.000774596666255453 MirTarget -0.109624102840946 3.47422532505056e-05 NA NA NA hsa-miR-335-5p RBL2 1.59953351087307 5.56170899867314e-05 -0.554881951006322 0.000774596666255453 miRNAWalker2_validate -0.126076376916647 1.15786986275277e-05 NA NA NA hsa-miR-421 RBL2 1.80720854070385 1.59709651202848e-07 -0.554881951006322 0.000774596666255453 miRanda -0.173135223671567 8.34206369604049e-08 NA NA NA hsa-miR-590-3p RBL2 1.11654983899947 0.000160782154924864 -0.554881951006322 0.000774596666255453 miRanda -0.125315066580303 0.0014460219589258 NA NA NA hsa-miR-93-5p RBL2 1.7515174434778 1.59386482413883e-08 -0.554881951006322 0.000774596666255453 MirTarget;miRNATAP -0.104755353156969 0.00439035106128891 NA NA NA hsa-miR-101-5p RELA -0.567139223563276 0.0306291767849722 0.140295374000207 0.30305268869391 mirMAP -0.114893897809984 0.00171325410868005 NA NA NA hsa-miR-30e-5p RELA -0.573784818166736 0.0112497802572927 0.140295374000207 0.30305268869391 miRNAWalker2_validate -0.152968732905743 0.000301446483160409 NA NA NA hsa-miR-107 RELN 0.904627575346218 4.67936495073904e-05 -4.29283459384144 8.98184533710992e-07 miRanda -1.42189335966196 4.31126233972053e-07 NA NA NA hsa-miR-128-3p RELN 0.98280381420517 5.77641850797209e-05 -4.29283459384144 8.98184533710992e-07 miRNAWalker2_validate;miRTarBase;MirTarget -1.26223408644892 7.59151838392541e-07 NA NA NA hsa-miR-15a-5p RELN 1.03783090449383 7.40334108980898e-07 -4.29283459384144 8.98184533710992e-07 MirTarget;miRNATAP -1.36017687806615 4.90862013971733e-06 NA NA NA hsa-miR-15b-5p RELN 1.62046407540723 5.42152621571078e-09 -4.29283459384144 8.98184533710992e-07 MirTarget;miRNATAP -1.31265180503781 1.02479305016313e-09 NA NA NA hsa-miR-16-5p RELN 1.00515772948091 5.33912942007619e-06 -4.29283459384144 8.98184533710992e-07 MirTarget;miRNATAP -1.2871092949858 5.55399574175418e-06 NA NA NA hsa-miR-200b-3p RELN 0.974577911407732 0.0595020056914543 -4.29283459384144 8.98184533710992e-07 MirTarget;TargetScan -0.769151438866476 7.12758348016052e-11 NA NA NA hsa-miR-200c-3p RELN 1.28185685499076 0.00369777635539177 -4.29283459384144 8.98184533710992e-07 MirTarget -0.934969733772364 8.37429710742509e-12 NA NA NA hsa-miR-27a-5p RELN 1.09051796355562 0.00189340505433517 -4.29283459384144 8.98184533710992e-07 miRNATAP -0.553504606793389 0.002206535269896 NA NA NA hsa-miR-34a-5p RELN 0.794251341270032 0.00024017386701179 -4.29283459384144 8.98184533710992e-07 miRNATAP -1.30549632532017 8.18198361798679e-06 NA NA NA hsa-miR-361-5p RELN 0.407725414130987 0.0181260969156347 -4.29283459384144 8.98184533710992e-07 MirTarget;PITA;miRanda -1.02774963324652 0.00721376280889747 NA NA NA hsa-miR-421 RELN 1.80720854070385 1.59709651202848e-07 -4.29283459384144 8.98184533710992e-07 miRanda -0.593845429834762 0.000949511403258343 NA NA NA hsa-miR-424-5p RELN 1.08509868581983 0.000420473853818268 -4.29283459384144 8.98184533710992e-07 MirTarget;miRNATAP -0.627717907395017 0.00233361014852916 NA NA NA hsa-miR-429 RELN 1.40182602301928 0.00900426780286475 -4.29283459384144 8.98184533710992e-07 MirTarget;PITA;miRanda;miRNATAP -0.782727121510202 3.23875606412863e-12 NA NA NA hsa-miR-455-3p RELN 2.29532323519288 1.85675588946527e-07 -4.29283459384144 8.98184533710992e-07 PITA -0.613709460740711 9.67326318743643e-06 NA NA NA hsa-miR-589-3p RELN 1.01962606923682 0.00577853347252709 -4.29283459384144 8.98184533710992e-07 MirTarget -0.484293451707528 0.00498169255879031 NA NA NA hsa-miR-590-3p RELN 1.11654983899947 0.000160782154924864 -4.29283459384144 8.98184533710992e-07 miRanda;miRNATAP -0.563309284591775 0.00873131870456404 NA NA NA hsa-miR-338-5p RHEB -1.19659203838734 0.0100316010080496 0.477054881122191 0.0131210521713065 MirTarget;PITA;miRNATAP -0.117522618826603 4.73448667777109e-05 NA NA NA hsa-miR-340-5p RPS6KB1 -0.164941927483643 0.529910509321278 -0.0504582113908647 0.727179436430059 mirMAP -0.120667175252136 0.00197996146589472 NA NA NA hsa-miR-125a-5p RPS6KB2 -0.878090699011564 0.000213630844319685 0.0265769630099237 0.903529405946182 miRanda -0.224677803871747 0.000539507740183902 NA NA NA hsa-miR-34a-5p RPTOR 0.794251341270032 0.00024017386701179 -0.135749151744642 0.363465138706982 mirMAP -0.166736089465341 0.000575913970334335 NA NA NA hsa-miR-107 SGK1 0.904627575346218 4.67936495073904e-05 -0.910621651729455 0.0364235932436203 miRanda -0.526426251160579 0.000143039217873213 NA NA NA hsa-miR-15a-5p SGK1 1.03783090449383 7.40334108980898e-07 -0.910621651729455 0.0364235932436203 miRNATAP -0.40309382194529 0.00608473378497111 NA NA NA hsa-miR-7-5p SGK1 1.63575693499363 0.0124424214624534 -0.910621651729455 0.0364235932436203 miRNATAP -0.291803201121022 8.09973276296258e-10 NA NA NA hsa-miR-107 SOS1 0.904627575346218 4.67936495073904e-05 -0.312504597403338 0.0217354056927372 miRNATAP -0.145548441179847 0.000689923594720433 NA NA NA hsa-miR-212-3p SOS1 0.960352937108106 0.00133449812322732 -0.312504597403338 0.0217354056927372 miRNATAP -0.10285303580697 0.00125914157136999 NA NA NA hsa-miR-130b-3p SOS2 1.32714007211004 4.78676252285191e-05 -0.552553272187832 0.000842904756234712 miRNATAP -0.189945286925012 4.30620481406807e-08 NA NA NA hsa-miR-140-5p SOS2 0.208193069681326 0.303002433893804 -0.552553272187832 0.000842904756234712 miRanda -0.242708772607705 4.09198894582034e-05 NA NA NA hsa-miR-15a-5p SOS2 1.03783090449383 7.40334108980898e-07 -0.552553272187832 0.000842904756234712 miRNATAP -0.146415389758913 0.00881073243847914 NA NA NA hsa-miR-15b-5p SOS2 1.62046407540723 5.42152621571078e-09 -0.552553272187832 0.000842904756234712 miRNATAP -0.20706350866124 2.57218450390641e-07 NA NA NA hsa-miR-16-5p SOS2 1.00515772948091 5.33912942007619e-06 -0.552553272187832 0.000842904756234712 miRNATAP -0.262605428938621 4.24308774338413e-07 NA NA NA hsa-miR-320a SOS2 0.593888711838028 0.011897419390526 -0.552553272187832 0.000842904756234712 miRanda;miRNATAP -0.171180096354768 0.000654323522825758 NA NA NA hsa-miR-320b SOS2 1.11183660885284 0.000497971211648503 -0.552553272187832 0.000842904756234712 miRanda;miRNATAP -0.1894426744384 1.1640268989058e-07 NA NA NA hsa-miR-320c SOS2 0.455072851945474 0.240613785444485 -0.552553272187832 0.000842904756234712 miRanda;miRNATAP -0.140084445378509 6.27193555893877e-05 NA NA NA hsa-miR-330-3p SOS2 0.798460296022179 0.00746538156533435 -0.552553272187832 0.000842904756234712 PITA;miRNATAP -0.138104773165596 0.000447681879316435 NA NA NA hsa-miR-335-5p SOS2 1.59953351087307 5.56170899867314e-05 -0.552553272187832 0.000842904756234712 miRNAWalker2_validate -0.169702199646938 1.79676990124387e-09 NA NA NA hsa-miR-421 SOS2 1.80720854070385 1.59709651202848e-07 -0.552553272187832 0.000842904756234712 miRanda -0.144587437231913 1.02531118763523e-05 NA NA NA hsa-miR-424-5p SOS2 1.08509868581983 0.000420473853818268 -0.552553272187832 0.000842904756234712 miRNATAP -0.140604926460313 0.000199731330671148 NA NA NA hsa-miR-543 SOS2 0.0323775903217254 0.929458442755522 -0.552553272187832 0.000842904756234712 miRanda -0.111995751787288 0.00169071143522402 NA NA NA hsa-miR-590-3p SOS2 1.11654983899947 0.000160782154924864 -0.552553272187832 0.000842904756234712 miRanda;mirMAP -0.153192018213884 9.25459377799179e-05 NA NA NA hsa-miR-590-5p SOS2 1.04171442093217 0.000272475544954865 -0.552553272187832 0.000842904756234712 PITA;miRanda;miRNATAP -0.180915954835414 7.34917806636463e-06 NA NA NA hsa-miR-139-5p SPP1 -1.83374360776637 1.22019901002824e-09 4.08243806089987 4.65153594324165e-07 miRanda -1.0978692410805 1.97313678323349e-09 NA NA NA hsa-miR-146a-5p SPP1 1.82051649415508 2.03651725047679e-05 4.08243806089987 4.65153594324165e-07 miRNAWalker2_validate -0.450709767193883 0.000899249563093426 NA NA NA hsa-miR-362-3p SPP1 -0.0349414695893027 0.913780708043777 4.08243806089987 4.65153594324165e-07 miRanda -0.628354921443493 0.000692475054752355 NA NA NA hsa-miR-577 SPP1 0.911619788986754 0.2256062124148 4.08243806089987 4.65153594324165e-07 miRNATAP -0.275226769397448 0.000608838686580323 NA NA NA hsa-miR-20a-5p STK11 1.4503375861709 5.7813456424762e-07 -0.203298821557102 0.29062016181051 MirTarget -0.12578955834794 0.00604542229657804 NA NA NA hsa-miR-99b-3p SYK 0.339188457691233 0.25957365506319 0.724612114305765 0.0261499394806022 miRNAWalker2_validate -0.30369146587768 8.15470051612586e-05 NA NA NA hsa-miR-455-5p TEK 1.20462751989145 6.74386011867484e-05 -1.42722193756898 0.000475412039481098 miRanda -0.484594750557798 2.54479265582421e-07 NA NA NA hsa-miR-129-5p TGFA -2.56914016541176 2.36237896095709e-06 1.61763558221504 5.79988353685113e-05 miRanda;mirMAP -0.207133950005876 7.95124452667339e-05 NA NA NA hsa-miR-140-3p TGFA -0.296251775392129 0.127539826012144 1.61763558221504 5.79988353685113e-05 miRNATAP -0.686146361756192 5.69340498351293e-06 NA NA NA hsa-miR-29b-2-5p TGFA -1.7015307882027 2.84239251703401e-10 1.61763558221504 5.79988353685113e-05 mirMAP -0.601645583066598 1.97477345184881e-09 NA NA NA hsa-miR-326 TGFA -0.429748586406214 0.2629894124021 1.61763558221504 5.79988353685113e-05 miRanda -0.227020831163258 0.00313889373116187 NA NA NA hsa-miR-338-5p TGFA -1.19659203838734 0.0100316010080496 1.61763558221504 5.79988353685113e-05 mirMAP -0.184244887734986 0.00305770189496924 NA NA NA hsa-let-7a-3p THBS1 0.503048155002889 0.0411145454335299 -1.24863771457813 0.00265778570679874 mirMAP -0.370316910362625 0.00243643875584214 NA NA NA hsa-let-7d-5p THBS1 0.981733854788227 7.26366577706469e-07 -1.24863771457813 0.00265778570679874 miRNAWalker2_validate -0.546987837424227 0.000232224726694981 NA NA NA hsa-miR-151a-3p THBS1 1.00322719901751 7.20903658270795e-06 -1.24863771457813 0.00265778570679874 MirTarget -0.73761432994829 9.23927372162971e-09 NA NA NA hsa-miR-16-1-3p THBS1 1.43227522002564 3.70920454953168e-08 -1.24863771457813 0.00265778570679874 MirTarget -0.475768138699209 1.58834110541284e-05 NA NA NA hsa-miR-17-5p THBS1 1.65862087862483 8.45603406215941e-08 -1.24863771457813 0.00265778570679874 miRNAWalker2_validate -0.477234270724459 1.76065486884735e-07 NA NA NA hsa-miR-182-5p THBS1 0.887369486030646 0.0310640781418789 -1.24863771457813 0.00265778570679874 MirTarget -0.309551358917175 1.40311941430649e-05 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-186-5p THBS1 0.149964130725901 0.434709542998771 -1.24863771457813 0.00265778570679874 mirMAP -0.520998790228557 0.00106972433199894 NA NA NA hsa-miR-18a-5p THBS1 2.20211504140984 1.78678887916334e-09 -1.24863771457813 0.00265778570679874 MirTarget -0.397796098250484 1.86835263945503e-07 NA NA NA hsa-miR-19a-3p THBS1 1.26669687448473 0.000105972838514412 -1.24863771457813 0.00265778570679874 MirTarget;mirMAP -0.373099495159569 2.8124340301922e-05 NA NA NA hsa-miR-19b-3p THBS1 0.759818275708988 0.00652779573186786 -1.24863771457813 0.00265778570679874 MirTarget;mirMAP -0.475934731509183 6.15248588571142e-06 NA NA NA hsa-miR-200a-5p THBS1 1.50371809098978 0.00263602434344863 -1.24863771457813 0.00265778570679874 MirTarget -0.391138424820444 2.988456435559e-12 NA NA NA hsa-miR-200b-5p THBS1 0.969871521250413 0.0530500454130183 -1.24863771457813 0.00265778570679874 MirTarget -0.428970652872064 2.73273845947343e-13 NA NA NA hsa-miR-20a-5p THBS1 1.4503375861709 5.7813456424762e-07 -1.24863771457813 0.00265778570679874 miRNAWalker2_validate -0.49794382461585 4.0938227581297e-07 NA NA NA hsa-miR-3065-5p THBS1 -0.241623656423063 0.633116553078159 -1.24863771457813 0.00265778570679874 MirTarget -0.249036989118658 3.04281341597343e-05 NA NA NA hsa-miR-32-5p THBS1 0.415247682945382 0.106458022460373 -1.24863771457813 0.00265778570679874 mirMAP -0.5555340737988 1.3387339745154e-06 NA NA NA hsa-miR-335-3p THBS1 2.5197689063267 2.20084506976733e-09 -1.24863771457813 0.00265778570679874 mirMAP -0.401833811450832 7.76964738276262e-10 NA NA NA hsa-miR-33a-3p THBS1 0.347011402017138 0.321709379745392 -1.24863771457813 0.00265778570679874 MirTarget;mirMAP -0.531341072213548 9.05114561069452e-10 NA NA NA hsa-miR-375 THBS1 -2.94506033785642 0.00570147601654791 -1.24863771457813 0.00265778570679874 miRanda -0.121276767953717 8.45936054053377e-06 NA NA NA hsa-miR-576-5p THBS1 0.625714137488957 0.0417100301848969 -1.24863771457813 0.00265778570679874 mirMAP -0.41902887625134 1.27872122980434e-05 NA NA NA hsa-miR-577 THBS1 0.911619788986754 0.2256062124148 -1.24863771457813 0.00265778570679874 mirMAP -0.235350281618529 1.68539263735026e-09 NA NA NA hsa-miR-590-3p THBS1 1.11654983899947 0.000160782154924864 -1.24863771457813 0.00265778570679874 miRanda -0.453209723492059 3.97290709629156e-06 NA NA NA hsa-miR-590-5p THBS1 1.04171442093217 0.000272475544954865 -1.24863771457813 0.00265778570679874 miRanda;mirMAP -0.477091842103574 2.72141337877697e-06 NA NA NA hsa-miR-616-5p THBS1 0.834052908652744 0.0347835664029363 -1.24863771457813 0.00265778570679874 mirMAP -0.231533516554552 0.00253501598736982 NA NA NA hsa-miR-629-3p THBS1 1.40326397107309 9.7803063526732e-05 -1.24863771457813 0.00265778570679874 MirTarget -0.437479666325319 3.50844628225438e-08 NA NA NA hsa-miR-7-1-3p THBS1 0.709309110750947 0.0412301737463194 -1.24863771457813 0.00265778570679874 MirTarget;mirMAP -0.367898102747668 1.39963947465173e-05 NA NA NA hsa-miR-92a-3p THBS1 1.2209325870225 6.8757197708107e-06 -1.24863771457813 0.00265778570679874 miRNAWalker2_validate -0.651028463510854 4.08823366684469e-10 NA NA NA hsa-miR-940 THBS1 1.64406174271686 0.000690854900107004 -1.24863771457813 0.00265778570679874 MirTarget -0.24008111432213 0.000798882289984547 NA NA NA hsa-miR-106b-5p THBS2 1.70863907461894 2.04074794107142e-08 1.37350866437698 0.0129752854334954 MirTarget -0.440457832160164 0.000432717084292189 NA NA NA hsa-miR-139-5p THBS2 -1.83374360776637 1.22019901002824e-09 1.37350866437698 0.0129752854334954 miRanda -0.688708303020105 1.88206306869675e-08 NA NA NA hsa-miR-142-5p THBS2 1.55592486377018 6.69269968016779e-06 1.37350866437698 0.0129752854334954 mirMAP -0.308007373998275 0.00610533418094202 NA NA NA hsa-miR-16-2-3p THBS2 1.8048179609245 2.83095715136409e-09 1.37350866437698 0.0129752854334954 mirMAP -0.338689543432002 0.00707068722064666 NA NA NA hsa-miR-29a-3p THBS2 -0.113012156986374 0.615005009685815 1.37350866437698 0.0129752854334954 MirTarget -0.729305331657521 3.98799108454678e-05 NA NA NA hsa-miR-29b-3p THBS2 -0.230693226193598 0.367461626035234 1.37350866437698 0.0129752854334954 MirTarget -0.625558466486523 5.42630924237139e-05 NA NA NA hsa-miR-29c-3p THBS2 -1.62454036584589 5.38376515586029e-07 1.37350866437698 0.0129752854334954 MirTarget -0.507936113984382 1.53033375740441e-05 NA NA NA hsa-miR-32-3p THBS2 0.583525764322974 0.11837203008551 1.37350866437698 0.0129752854334954 miRNATAP -0.474999749946423 5.82517221808817e-05 NA NA NA hsa-miR-320a THBS2 0.593888711838028 0.011897419390526 1.37350866437698 0.0129752854334954 mirMAP -0.471079112967222 0.00536169354189666 NA NA NA hsa-miR-320b THBS2 1.11183660885284 0.000497971211648503 1.37350866437698 0.0129752854334954 mirMAP -0.365660979087471 0.00290369121195031 NA NA NA hsa-miR-3614-5p THBS2 1.10426689932954 0.00706308396674599 1.37350866437698 0.0129752854334954 miRNATAP -0.274609136175736 0.00474383470091683 NA NA NA hsa-miR-590-3p THBS2 1.11654983899947 0.000160782154924864 1.37350866437698 0.0129752854334954 miRanda;mirMAP -0.546312745533517 3.0323695758298e-05 NA NA NA hsa-miR-590-5p THBS2 1.04171442093217 0.000272475544954865 1.37350866437698 0.0129752854334954 miRanda -0.469376124829186 0.0005951523629776 NA NA NA hsa-miR-598-3p THBS2 -0.386724439940895 0.290183721937095 1.37350866437698 0.0129752854334954 MirTarget -0.35042284264785 0.00120759407098702 NA NA NA hsa-miR-7-1-3p THBS2 0.709309110750947 0.0412301737463194 1.37350866437698 0.0129752854334954 MirTarget;mirMAP -0.57975425143221 1.83341309606968e-07 NA NA NA hsa-miR-330-5p THBS3 0.488365986827708 0.0512207630808233 -0.441540796140534 0.0454318161114979 PITA;miRNATAP -0.325712224176433 1.24328251911399e-07 NA NA NA hsa-miR-335-5p THBS3 1.59953351087307 5.56170899867314e-05 -0.441540796140534 0.0454318161114979 miRNAWalker2_validate -0.182200448742394 1.71730362028792e-06 NA NA NA hsa-miR-550a-5p THBS3 2.27360629906903 2.14504977831873e-07 -0.441540796140534 0.0454318161114979 MirTarget -0.180583380859782 1.00709757346033e-07 NA NA NA hsa-miR-320a THBS4 0.593888711838028 0.011897419390526 -1.87570880935441 0.0843917375645966 miRanda -1.29658593286843 7.77908267862424e-05 NA NA NA hsa-miR-320b THBS4 1.11183660885284 0.000497971211648503 -1.87570880935441 0.0843917375645966 miRanda -1.18590449362497 4.80794657615418e-07 NA NA NA hsa-miR-320c THBS4 0.455072851945474 0.240613785444485 -1.87570880935441 0.0843917375645966 miRanda -0.812349972713246 0.000435094663128124 NA NA NA hsa-miR-335-5p TLR2 1.59953351087307 5.56170899867314e-05 1.0615162114113 0.00245806827424737 miRNAWalker2_validate -0.284080204033391 3.47820696967303e-06 NA NA NA hsa-miR-17-5p TLR4 1.65862087862483 8.45603406215941e-08 -0.689896114378256 0.101728309062005 TargetScan -0.350138690384154 0.000180950121601467 NA NA NA hsa-miR-331-5p TLR4 1.0778596491846 2.79470024753813e-05 -0.689896114378256 0.101728309062005 MirTarget -0.417351890857908 0.000280336029517074 NA NA NA hsa-miR-335-5p TLR4 1.59953351087307 5.56170899867314e-05 -0.689896114378256 0.101728309062005 miRNAWalker2_validate -0.217651220493171 0.00339439256381355 NA NA NA hsa-miR-590-3p TLR4 1.11654983899947 0.000160782154924864 -0.689896114378256 0.101728309062005 miRanda;mirMAP -0.2997902647501 0.00284006620884028 NA NA NA hsa-miR-590-5p TLR4 1.04171442093217 0.000272475544954865 -0.689896114378256 0.101728309062005 miRanda -0.434788255728195 2.38114913264349e-05 NA NA NA hsa-miR-944 TLR4 3.33123095809751 0.0177835044930391 -0.689896114378256 0.101728309062005 miRNATAP -0.103073521311652 3.4591228401214e-05 NA NA NA hsa-miR-126-5p TNC 0.41765430251855 0.0753161203651532 0.961893359853532 0.177941026307477 miRNATAP -0.983390994749709 5.2459973603903e-06 NA NA NA hsa-miR-326 TNC -0.429748586406214 0.2629894124021 0.961893359853532 0.177941026307477 MirTarget;miRanda;miRNATAP -0.695390877950542 1.05430372708077e-07 NA NA NA hsa-miR-330-3p TNC 0.798460296022179 0.00746538156533435 0.961893359853532 0.177941026307477 MirTarget -0.442492776074701 0.00951460349625162 NA NA NA hsa-miR-330-5p TNC 0.488365986827708 0.0512207630808233 0.961893359853532 0.177941026307477 MirTarget;miRanda;miRNATAP -0.557515682229666 0.0065862461944099 NA NA NA hsa-miR-335-5p TNC 1.59953351087307 5.56170899867314e-05 0.961893359853532 0.177941026307477 miRNAWalker2_validate;miRTarBase -0.77847754082114 1.10622361056312e-10 NA NA NA hsa-miR-425-5p TNC 1.13924952403101 0.000255357546232931 0.961893359853532 0.177941026307477 MirTarget -0.773139534334497 1.07174674118418e-06 NA NA NA hsa-miR-501-5p TNC 0.266919328110625 0.454779001968586 0.961893359853532 0.177941026307477 miRNATAP -0.919424595130222 1.57363704377471e-11 NA NA NA hsa-miR-140-5p TNN 0.208193069681326 0.303002433893804 -0.41024033419156 0.510347158051212 PITA;miRanda -0.727416874748608 0.00114804735644931 NA NA NA hsa-miR-1301-3p TNXB 1.59017279464031 4.6624715470094e-06 -4.45246996245603 2.01551594021759e-10 miRNAWalker2_validate -0.740450250562827 2.80636426782143e-07 NA NA NA hsa-miR-23a-3p TSC1 1.10685926969665 3.16223452471768e-08 -0.564690517834756 7.84053178401563e-05 mirMAP -0.239924332441061 1.17024444416688e-06 NA NA NA hsa-miR-1-3p VEGFA -2.66410453456934 1.50620580537836e-05 0.409900110754973 0.180026099055787 MirTarget -0.176948917904965 1.45151759893735e-07 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-101-3p VEGFA -0.451263906815861 0.0283387250173031 0.409900110754973 0.180026099055787 miRNAWalker2_validate -0.335417986089274 0.00174980396829274 NA NA NA hsa-miR-129-5p VEGFA -2.56914016541176 2.36237896095709e-06 0.409900110754973 0.180026099055787 miRanda -0.105947559794297 0.00736909643879352 NA NA NA hsa-miR-133a-3p VEGFA -3.07408796787523 8.17423849601445e-07 0.409900110754973 0.180026099055787 miRNAWalker2_validate -0.162820736618245 8.37210469369392e-07 NA NA NA hsa-miR-145-5p VEGFA -1.75133578902314 1.54965572197748e-05 0.409900110754973 0.180026099055787 miRNAWalker2_validate;miRTarBase -0.220438811665314 2.09241456816908e-05 24781864;24966896;22472569 Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically metastasis;; thyroid cancer;bladder cancer;sarcoma hsa-miR-199a-5p VEGFA 0.371973504507027 0.232661597228763 0.409900110754973 0.180026099055787 miRanda;miRNATAP -0.211547585175076 0.00251514147236996 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-128-3p VEGFC 0.98280381420517 5.77641850797209e-05 0.195788328347819 0.656066637612163 miRNAWalker2_validate;MirTarget -0.546088637678822 1.30628253642657e-05 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-16-2-3p VEGFC 1.8048179609245 2.83095715136409e-09 0.195788328347819 0.656066637612163 MirTarget -0.260465880829614 0.00866041293845893 NA NA NA hsa-miR-3662 VEGFC 1.82780708047676 0.0054036501346178 0.195788328347819 0.656066637612163 MirTarget -0.187356869827338 0.00206421517630613 NA NA NA hsa-miR-15b-5p VWF 1.62046407540723 5.42152621571078e-09 -0.899022649047829 0.0211839071191392 mirMAP -0.298400017372083 0.00208117064254572 NA NA NA hsa-miR-16-5p VWF 1.00515772948091 5.33912942007619e-06 -0.899022649047829 0.0211839071191392 mirMAP -0.415987898911922 0.000860015503615006 NA NA NA hsa-miR-424-5p VWF 1.08509868581983 0.000420473853818268 -0.899022649047829 0.0211839071191392 mirMAP -0.298642059322598 0.000850251881727651 NA NA NA hsa-miR-218-5p YWHAB -0.987730614742492 0.0108295837207062 0.560953273192444 3.96438720523435e-05 MirTarget;miRNATAP -0.132643605810655 5.34245751955568e-08 NA NA NA hsa-miR-28-3p YWHAB -0.730670593501133 0.000351503999708671 0.560953273192444 3.96438720523435e-05 mirMAP -0.201074933049334 2.31268016134537e-05 NA NA NA hsa-miR-29b-2-5p YWHAE -1.7015307882027 2.84239251703401e-10 0.589666273640299 0.000303774555361019 MirTarget -0.283442585158459 6.04869989497828e-13 NA NA NA hsa-miR-30a-3p YWHAE -1.73205137750899 3.2425754511091e-07 0.589666273640299 0.000303774555361019 miRNAWalker2_validate;MirTarget;miRNATAP -0.122887316569407 0.000220217281793117 NA NA NA hsa-miR-30a-5p YWHAE -1.71922855140016 3.20574349285256e-07 0.589666273640299 0.000303774555361019 miRNAWalker2_validate -0.162000089779657 9.7810828573082e-07 NA NA NA hsa-miR-139-5p YWHAG -1.83374360776637 1.22019901002824e-09 0.786064999170599 8.42926791804072e-05 MirTarget;PITA;miRanda;miRNATAP -0.233897074977505 1.76624963351128e-07 NA NA NA hsa-miR-140-3p YWHAG -0.296251775392129 0.127539826012144 0.786064999170599 8.42926791804072e-05 MirTarget;PITA;miRNATAP -0.378974206830825 3.19734199541644e-07 NA NA NA hsa-miR-148a-3p YWHAG -1.53721533763578 3.55533747293117e-05 0.786064999170599 8.42926791804072e-05 mirMAP -0.207644440245434 1.84352771112896e-08 NA NA NA hsa-miR-148b-3p YWHAG 0.295175884456199 0.17466422420702 0.786064999170599 8.42926791804072e-05 mirMAP -0.185299344730775 0.00603097910246455 NA NA NA hsa-miR-181c-5p YWHAG 0.336826967681288 0.112932307913601 0.786064999170599 8.42926791804072e-05 MirTarget;miRNATAP -0.25588328816477 0.000187835020300278 NA NA NA hsa-miR-217 YWHAG -0.0121404731225336 0.980818372851502 0.786064999170599 8.42926791804072e-05 MirTarget;PITA;miRanda;miRNATAP -0.147034916555345 1.2228899839513e-07 NA NA NA hsa-miR-30a-5p YWHAG -1.71922855140016 3.20574349285256e-07 0.786064999170599 8.42926791804072e-05 miRNATAP -0.196811149472458 1.43906773606096e-06 NA NA NA hsa-miR-30b-5p YWHAG -0.430720743745757 0.0593564057320791 0.786064999170599 8.42926791804072e-05 miRNATAP -0.257903077785551 4.47785555025729e-05 NA NA NA hsa-miR-30c-5p YWHAG -0.983130268805942 4.60419218706127e-05 0.786064999170599 8.42926791804072e-05 miRNATAP -0.220075232527337 0.000185668060209576 NA NA NA hsa-miR-30d-5p YWHAG -0.5492586056147 0.0140125082460125 0.786064999170599 8.42926791804072e-05 miRNATAP -0.213526360715379 0.00100328280019275 NA NA NA hsa-miR-338-5p YWHAG -1.19659203838734 0.0100316010080496 0.786064999170599 8.42926791804072e-05 PITA;miRNATAP -0.11095194976889 0.000280249373758779 NA NA NA hsa-miR-361-3p YWHAG -0.126462931388735 0.566052688733137 0.786064999170599 8.42926791804072e-05 miRNATAP -0.282376760792372 1.74886615897343e-05 NA NA NA hsa-miR-500a-5p YWHAG 0.00337014556047865 0.992120109131868 0.786064999170599 8.42926791804072e-05 MirTarget;miRNATAP -0.183877094182199 1.09597495079572e-05 NA NA NA hsa-miR-625-3p YWHAG -0.185298294014366 0.626215541224408 0.786064999170599 8.42926791804072e-05 MirTarget -0.138559000351507 0.000237647988117345 NA NA NA hsa-let-7f-5p YWHAQ 0.634633924115866 0.0344982923411787 0.332508468080446 0.0893671775677139 miRNAWalker2_validate -0.135613273474918 0.00338792114275032 NA NA NA hsa-miR-139-5p YWHAQ -1.83374360776637 1.22019901002824e-09 0.332508468080446 0.0893671775677139 MirTarget;PITA;miRanda;miRNATAP -0.149575828728304 0.000675738998730082 NA NA NA hsa-miR-140-5p YWHAQ 0.208193069681326 0.303002433893804 0.332508468080446 0.0893671775677139 miRanda -0.247121691653543 0.00040094290892181 NA NA NA hsa-miR-195-5p YWHAQ -0.907998841926297 0.00150511564650591 0.332508468080446 0.0893671775677139 MirTarget;miRNATAP -0.172346531798579 0.000330508930253542 NA NA NA hsa-miR-497-5p YWHAQ -0.801030912431774 0.00360386743876612 0.332508468080446 0.0893671775677139 MirTarget;miRNATAP -0.190571360702168 0.000136707529898457 NA NA NA hsa-miR-125a-5p YWHAZ -0.878090699011564 0.000213630844319685 0.910846108792837 3.95356455522822e-05 miRanda -0.2963263935549 8.08143300917313e-06 NA NA NA hsa-miR-129-5p YWHAZ -2.56914016541176 2.36237896095709e-06 0.910846108792837 3.95356455522822e-05 miRanda -0.100589986472573 0.000512352503638405 NA NA NA hsa-miR-140-3p YWHAZ -0.296251775392129 0.127539826012144 0.910846108792837 3.95356455522822e-05 MirTarget;PITA;miRNATAP -0.485218364242567 2.60009968767316e-09 NA NA NA hsa-miR-195-3p YWHAZ -1.34779269408059 2.01619826639376e-05 0.910846108792837 3.95356455522822e-05 MirTarget -0.258353646708993 1.21967510972882e-07 NA NA NA hsa-miR-217 YWHAZ -0.0121404731225336 0.980818372851502 0.910846108792837 3.95356455522822e-05 miRanda -0.152196035725098 9.61806411845085e-07 NA NA NA hsa-miR-28-5p YWHAZ -0.238617853755144 0.167318538669818 0.910846108792837 3.95356455522822e-05 PITA;miRanda;miRNATAP -0.360580666571329 0.000148316235198698 NA NA NA hsa-miR-30a-5p YWHAZ -1.71922855140016 3.20574349285256e-07 0.910846108792837 3.95356455522822e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.289090361794288 6.87659241068155e-11 NA NA NA hsa-miR-30c-5p YWHAZ -0.983130268805942 4.60419218706127e-05 0.910846108792837 3.95356455522822e-05 MirTarget;miRNATAP -0.294131949452993 5.89454758802094e-06 24519092 Involvement of miR 30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells; Together our findings provided evidence that miR-30c was one of the important miRNAs in doxorubicin resistance by regulating YWHAZ in the breast cancer cell line MCF-7/ADR drug resistance breast cancer hsa-miR-30e-5p YWHAZ -0.573784818166736 0.0112497802572927 0.910846108792837 3.95356455522822e-05 MirTarget;miRNATAP -0.223629791120878 0.00170925393290396 NA NA NA hsa-miR-338-5p YWHAZ -1.19659203838734 0.0100316010080496 0.910846108792837 3.95356455522822e-05 mirMAP -0.116394082658444 0.000624841952889922 NA NA NA hsa-miR-340-3p YWHAZ -0.54276408676339 0.0739694056098475 0.910846108792837 3.95356455522822e-05 miRNAWalker2_validate -0.137139821904965 0.00968831074205658 NA NA NA hsa-miR-664a-3p YWHAZ -0.83041219170254 0.000136267547251167 0.910846108792837 3.95356455522822e-05 mirMAP -0.226096100567498 0.00210502900459849 NA NA NA