miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-21-5p AKT2 1.51084295924322 1.54551622173259e-34 -0.343608685894869 1.25471482871759e-05 miRNAWalker2_validate -0.246625533117166 4.43585626011661e-19 NA NA NA hsa-miR-330-5p AKT2 0.442231058604099 0.0053308560843808 -0.343608685894869 1.25471482871759e-05 miRanda -0.10429759179516 1.49133299948889e-05 NA NA NA hsa-miR-342-3p AKT2 -0.319677314984262 0.0449813878317147 -0.343608685894869 1.25471482871759e-05 mirMAP -0.124944719707983 1.72780303356483e-07 NA NA NA hsa-miR-106b-5p AKT3 0.648901865047099 8.24870862047885e-09 -0.658799312069129 0.000471762262250455 miRNATAP -0.257549207275002 0.00147770551388523 NA NA NA hsa-miR-107 AKT3 0.241662461253461 0.0170788899505389 -0.658799312069129 0.000471762262250455 PITA;miRanda -0.603074134996255 1.95007791380395e-11 NA NA NA hsa-miR-122-5p AKT3 -1.23907441373955 4.42181244888642e-06 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase -0.282597613468804 3.13172096832783e-18 24244539 miR 122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3; Here we identify AKT3 as a novel and direct target of miR-122; Restoration of miR-122 expression in HCC cell lines decreases AKT3 levels inhibits cell migration and proliferation and induces apoptosis; These anti-tumor phenotypes can be rescued by reconstitution of AKT3 expression indicating the essential role of AKT3 in miR-122 mediated HCC transformation; Our data strongly suggest that miR-122 is a tumor suppressor that targets AKT3 to regulate tumorigenesis in HCCs and a potential therapeutic candidate for liver cancer tumorigenesis;cell migration liver cancer hsa-miR-146b-5p AKT3 0.419719546795449 0.0457375823220155 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate -0.159678144375669 0.000263366078999813 NA NA NA hsa-miR-15a-5p AKT3 0.349521211668244 0.000770735998804736 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265425410812535 0.00291348888530609 NA NA NA hsa-miR-17-3p AKT3 0.410352776142368 0.00422200500748636 -0.658799312069129 0.000471762262250455 miRNATAP -0.350392140268267 3.46133659001702e-08 NA NA NA hsa-miR-17-5p AKT3 0.698861147045461 2.43854106455398e-05 -0.658799312069129 0.000471762262250455 TargetScan;miRNATAP -0.290786763807918 1.04942988053081e-07 NA NA NA hsa-miR-20a-5p AKT3 0.854326758727003 5.04256669663285e-07 -0.658799312069129 0.000471762262250455 miRNATAP -0.294574079686222 2.60181650003526e-08 NA NA NA hsa-miR-32-3p AKT3 0.219109440121582 0.207217051619543 -0.658799312069129 0.000471762262250455 mirMAP -0.225932925933496 3.62088303609835e-05 NA NA NA hsa-miR-33a-3p AKT3 -0.683025859637737 1.01106097756419e-05 -0.658799312069129 0.000471762262250455 mirMAP -0.229716914608906 0.000100074832030455 NA NA NA hsa-miR-362-3p AKT3 0.814007335895913 2.00108618836568e-09 -0.658799312069129 0.000471762262250455 miRanda -0.223301194831745 0.00083465748836002 NA NA NA hsa-miR-362-5p AKT3 0.717921690799312 1.68392734504524e-05 -0.658799312069129 0.000471762262250455 PITA;TargetScan;miRNATAP -0.147261080417749 0.00734435768679755 NA NA NA hsa-miR-374a-5p AKT3 0.016390363747302 0.869784217438621 -0.658799312069129 0.000471762262250455 mirMAP -0.277843537840681 0.00293899073092604 NA NA NA hsa-miR-502-3p AKT3 0.659598854007546 3.01316453996423e-08 -0.658799312069129 0.000471762262250455 miRNATAP -0.256952206617794 0.000795069967308112 NA NA NA hsa-miR-616-5p AKT3 0.150569904638223 0.402836556304524 -0.658799312069129 0.000471762262250455 mirMAP -0.200000357827185 9.73725948226915e-05 NA NA NA hsa-miR-93-5p AKT3 1.39518349670953 2.84167728726712e-25 -0.658799312069129 0.000471762262250455 miRNATAP -0.283992832133781 1.04884093066001e-05 NA NA NA hsa-miR-204-5p ARRB1 -0.537962150012103 0.0330895493358849 -0.702272068651583 0.000133773859833258 MirTarget -0.162719903395756 4.35602023601922e-06 NA NA NA hsa-miR-361-5p ARRB1 0.233202959858696 0.00961572812255327 -0.702272068651583 0.000133773859833258 MirTarget;miRanda -0.300383749296904 0.00301339236547059 NA NA NA hsa-miR-365a-3p ARRB2 0.164591326307714 0.15325084963213 0.0214645904641184 0.845797149694458 MirTarget;miRNATAP -0.150954166777644 0.00124759706001617 NA NA NA hsa-miR-21-5p ATF2 1.51084295924322 1.54551622173259e-34 -0.239353619837203 0.156190712870845 miRNAWalker2_validate -0.180342957288245 0.00335655702560994 NA NA NA hsa-miR-30b-5p ATF2 -0.54056186708617 2.44688760798341e-05 -0.239353619837203 0.156190712870845 mirMAP -0.223536389725042 0.000452180499441184 NA NA NA hsa-miR-107 BDNF 0.241662461253461 0.0170788899505389 0.0509404608382562 0.831886089502745 MirTarget;PITA;miRanda;miRNATAP -0.548625326436466 1.91129941815694e-06 27498977 MicroRNA 107 inhibits tumor growth and metastasis by targeting the BDNF mediated PI3K/AKT pathway in human non small lung cancer; In addition BDNF expression was upregulated and inversely correlated with miR-107 in NSCLC tissues; Enforced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-107 on NSCLC proliferation migration and invasion; miR-107 overexpression or downregulation of BDNF was able to inhibit activation of PI3K/AKT signaling pathway; Taken together our findings present the first evidence that miR-107 could suppress NSCLC metastasis by targeting BDNF and indirectly regulating PI3K/AKT signaling pathway which might lead to a potential therapeutic strategy focusing on miR-107 and BDNF for human NSCLC metastasis lung cancer hsa-miR-148a-5p BDNF -0.767626696027761 1.08359477494797e-06 0.0509404608382562 0.831886089502745 mirMAP -0.25723398567524 0.00044233258998089 NA NA NA hsa-miR-192-3p BDNF -0.6401165114007 0.000266272092403814 0.0509404608382562 0.831886089502745 MirTarget;miRNATAP -0.316265894039516 1.40962674503077e-06 NA NA NA hsa-miR-30d-5p BDNF 0.718283816348023 2.47422074061352e-08 0.0509404608382562 0.831886089502745 miRNATAP -0.295547331188199 0.000945690035537912 NA NA NA hsa-miR-589-5p BDNF 1.18593770505086 1.01781241960531e-22 0.0509404608382562 0.831886089502745 miRNATAP -0.237064825478246 0.0099909566497615 NA NA NA hsa-miR-107 CACNA1C 0.241662461253461 0.0170788899505389 0.946440250430891 1.06436399202531e-05 miRNATAP -0.481057860501473 4.10631389616242e-06 NA NA NA hsa-miR-186-5p CACNA1C -0.060103391373687 0.535288717081205 0.946440250430891 1.06436399202531e-05 mirMAP -0.51766118153573 2.3117422242455e-06 NA NA NA hsa-miR-192-5p CACNA1C -0.50188499512787 0.00344713341196035 0.946440250430891 1.06436399202531e-05 mirMAP -0.485416252348342 3.06182549190867e-16 NA NA NA hsa-miR-19b-1-5p CACNA1C -0.277804782598538 0.0783067794722916 0.946440250430891 1.06436399202531e-05 MirTarget -0.202853557350237 0.0025097494421374 NA NA NA hsa-miR-26b-5p CACNA1C -1.10804856399744 4.14176110314282e-22 0.946440250430891 1.06436399202531e-05 MirTarget;miRNATAP -0.312603600835431 0.00037221556825953 NA NA NA hsa-miR-30e-5p CACNA1C -0.627815042856657 3.02205690184908e-10 0.946440250430891 1.06436399202531e-05 mirMAP -0.383622413991233 0.000242519659254916 NA NA NA hsa-miR-33a-5p CACNA1C -0.767474460958522 1.09948756118522e-05 0.946440250430891 1.06436399202531e-05 MirTarget -0.278331996550691 2.98414343150603e-06 NA NA NA hsa-miR-33b-5p CACNA1C -2.28852395459234 2.69046626645242e-22 0.946440250430891 1.06436399202531e-05 MirTarget -0.179942561302315 2.37316566999313e-05 NA NA NA hsa-miR-378a-5p CACNA1C -1.58667444700188 3.19640857320504e-17 0.946440250430891 1.06436399202531e-05 MirTarget -0.185909559583795 0.000567634965839222 NA NA NA hsa-miR-532-5p CACNA1C 1.02729546510601 9.93318913966636e-16 0.946440250430891 1.06436399202531e-05 PITA -0.224232314769283 0.00511508088101446 NA NA NA hsa-miR-618 CACNA1C 0.13539895350352 0.517145913114103 0.946440250430891 1.06436399202531e-05 PITA -0.312273683198915 1.42231680765158e-09 NA NA NA hsa-miR-7-1-3p CACNA1C -0.569105143287799 1.85297665041424e-05 0.946440250430891 1.06436399202531e-05 MirTarget -0.352915048320912 7.16827322210876e-06 NA NA NA hsa-miR-93-3p CACNA1C 0.402821129107592 0.00131324842735588 0.946440250430891 1.06436399202531e-05 mirMAP -0.346247715057671 3.74998541285938e-05 NA NA NA hsa-let-7a-2-3p CACNA1D -1.19254913456912 1.47840144520517e-08 0.0773051512884277 0.775671886109236 MirTarget -0.194465653688002 0.00174399805490052 NA NA NA hsa-miR-101-3p CACNA1D -1.48176407980989 3.98950707385704e-31 0.0773051512884277 0.775671886109236 miRNATAP -0.433874608380917 5.48674401427686e-06 NA NA NA hsa-miR-139-5p CACNA1D -2.11299531796557 8.16407076415038e-28 0.0773051512884277 0.775671886109236 miRanda -0.229233752743874 0.00031572268935691 NA NA NA hsa-miR-144-3p CACNA1D -2.97536914478815 6.00546047309683e-28 0.0773051512884277 0.775671886109236 miRNATAP -0.136516465684352 0.00259740702432529 NA NA NA hsa-miR-148a-5p CACNA1D -0.767626696027761 1.08359477494797e-06 0.0773051512884277 0.775671886109236 MirTarget;miRNATAP -0.493852630269608 1.42668490775728e-09 NA NA NA hsa-let-7a-2-3p CACNA1E -1.19254913456912 1.47840144520517e-08 1.61336046300478 3.88892981462269e-05 mirMAP -0.435131146441737 1.33029776492485e-06 NA NA NA hsa-let-7a-5p CACNA1E -0.328069937201898 0.000464344093744051 1.61336046300478 3.88892981462269e-05 TargetScan;miRNATAP -1.16201345216975 1.25526756388031e-08 NA NA NA hsa-let-7b-5p CACNA1E -0.959013717270803 5.95127281258643e-11 1.61336046300478 3.88892981462269e-05 miRNATAP -0.577794833541408 6.30098366622733e-06 NA NA NA hsa-let-7f-5p CACNA1E -0.230160552243429 0.103292420192651 1.61336046300478 3.88892981462269e-05 miRNATAP -0.528970212061483 0.000105380348149084 NA NA NA hsa-let-7g-3p CACNA1E -1.14091000722297 8.32736018188759e-19 1.61336046300478 3.88892981462269e-05 mirMAP -0.650055124626601 5.25050081182415e-06 NA NA NA hsa-let-7g-5p CACNA1E -0.461294133285527 2.17210114729901e-05 1.61336046300478 3.88892981462269e-05 miRNATAP -0.979369855165654 2.15272631873028e-08 NA NA NA hsa-miR-101-5p CACNA1E -1.0634649894055 4.39116719827902e-16 1.61336046300478 3.88892981462269e-05 mirMAP -0.592569280212088 2.9261657405952e-05 NA NA NA hsa-miR-125b-2-3p CACNA1E -1.6609436107315 5.71534047969855e-18 1.61336046300478 3.88892981462269e-05 mirMAP -0.587370405519264 5.23269540014816e-10 NA NA NA hsa-miR-148a-3p CACNA1E -0.748702855596996 3.93313343865641e-07 1.61336046300478 3.88892981462269e-05 mirMAP -0.551916698525026 1.72909128498258e-05 NA NA NA hsa-miR-148a-5p CACNA1E -0.767626696027761 1.08359477494797e-06 1.61336046300478 3.88892981462269e-05 mirMAP -0.500030282182667 3.35976169497632e-05 NA NA NA hsa-miR-195-3p CACNA1E -1.09375690196245 4.70092324819807e-09 1.61336046300478 3.88892981462269e-05 mirMAP -0.379847566798827 0.000208135858086685 NA NA NA hsa-miR-195-5p CACNA1E -1.85907534356434 1.47434041676402e-22 1.61336046300478 3.88892981462269e-05 MirTarget -0.435262615554243 4.95666194322937e-06 NA NA NA hsa-miR-28-5p CACNA1E -0.430964830599964 2.67367257252925e-06 1.61336046300478 3.88892981462269e-05 mirMAP -1.04156041524479 5.66783671823449e-07 NA NA NA hsa-miR-3065-3p CACNA1E -1.04244468016704 4.60743424372577e-05 1.61336046300478 3.88892981462269e-05 MirTarget;miRNATAP -0.316240232670093 2.03203127629675e-05 NA NA NA hsa-miR-30a-3p CACNA1E -1.52720594401486 1.3830066075708e-17 1.61336046300478 3.88892981462269e-05 MirTarget;mirMAP;miRNATAP -0.608844204137594 2.24142770183656e-09 NA NA NA hsa-miR-30e-3p CACNA1E -1.20845647373031 3.10263633528203e-25 1.61336046300478 3.88892981462269e-05 MirTarget;mirMAP;miRNATAP -0.991007140641643 1.10794844969372e-10 NA NA NA hsa-miR-3614-5p CACNA1E -1.66311416965679 1.26647181860439e-15 1.61336046300478 3.88892981462269e-05 mirMAP -0.371208229626371 3.79226660099569e-05 NA NA NA hsa-miR-378a-5p CACNA1E -1.58667444700188 3.19640857320504e-17 1.61336046300478 3.88892981462269e-05 MirTarget -0.465224004223614 1.92058856288175e-06 NA NA NA hsa-miR-424-5p CACNA1E -2.62653257498508 2.38997974737991e-50 1.61336046300478 3.88892981462269e-05 MirTarget -0.274692842643168 0.00450882167019575 NA NA NA hsa-miR-497-5p CACNA1E -1.41371173021948 7.09278946477743e-17 1.61336046300478 3.88892981462269e-05 MirTarget -0.287304192452637 0.00879377343701754 NA NA NA hsa-miR-505-3p CACNA1E -1.20027021591555 1.27927500175937e-13 1.61336046300478 3.88892981462269e-05 mirMAP -0.395821976338104 0.000600796114844765 NA NA NA hsa-miR-548b-3p CACNA1E -0.0203576084717134 0.930819503166956 1.61336046300478 3.88892981462269e-05 mirMAP;miRNATAP -0.309369639408941 0.000198493206658511 NA NA NA hsa-miR-7-1-3p CACNA1E -0.569105143287799 1.85297665041424e-05 1.61336046300478 3.88892981462269e-05 mirMAP -0.503943656083323 0.00046646090991967 NA NA NA hsa-miR-32-5p CACNA1H 0.0806126674664016 0.548984992497432 -1.05436994328177 0.00919500862894367 miRNATAP -0.476727713085879 0.00124905930229757 NA NA NA hsa-miR-361-3p CACNA1H 0.275658012727111 0.00549374744374488 -1.05436994328177 0.00919500862894367 MirTarget;mirMAP -0.527066097268785 0.00872315650904543 NA NA NA hsa-miR-326 CACNA1I -1.881935132554 1.68087316863775e-21 0.68856788879411 0.0811087983044381 mirMAP -0.265501913404873 0.00449936140648039 NA NA NA hsa-miR-766-3p CACNA1I 0.199979324759329 0.257230732626744 0.68856788879411 0.0811087983044381 mirMAP -0.687838012514111 1.36254139529555e-10 NA NA NA hsa-miR-92a-3p CACNA1I 0.212391012518195 0.134292268089997 0.68856788879411 0.0811087983044381 MirTarget;miRNATAP -0.413225477327785 0.00240320239958241 NA NA NA hsa-miR-34a-5p CACNA2D2 1.03694231790865 5.74864019540594e-14 -0.352692703137883 0.11173297477812 mirMAP -0.228063531597874 0.00272261615796924 NA NA NA hsa-miR-193a-3p CACNA2D3 -0.117675551589896 0.309391958208578 0.363185883059655 0.207081897289803 miRanda -0.493744078798315 4.82329193262396e-05 NA NA NA hsa-miR-28-5p CACNA2D3 -0.430964830599964 2.67367257252925e-06 0.363185883059655 0.207081897289803 miRanda -0.705409767275472 3.33465719023729e-06 NA NA NA hsa-miR-590-3p CACNA2D3 -0.473167498047808 1.76652934637227e-05 0.363185883059655 0.207081897289803 miRanda -0.478052358447267 0.000158612742094894 NA NA NA hsa-miR-125b-5p CACNB1 -1.35767721102906 1.16564617395164e-18 0.939348723305902 1.32471032656652e-07 mirMAP;miRNATAP -0.255108519923935 2.72054558567938e-06 NA NA NA hsa-miR-29a-5p CACNB2 -0.113555908626946 0.349622266470788 -0.29382108956174 0.151148181646888 MirTarget -0.215750201888958 0.00913947375017152 NA NA NA hsa-miR-107 CACNB3 0.241662461253461 0.0170788899505389 0.956313502086209 1.97444325628267e-08 miRanda -0.568534935878929 4.16397840131617e-12 NA NA NA hsa-miR-186-5p CACNB3 -0.060103391373687 0.535288717081205 0.956313502086209 1.97444325628267e-08 miRNATAP -0.421814028136991 1.38447860773885e-06 NA NA NA hsa-let-7b-5p CACNB4 -0.959013717270803 5.95127281258643e-11 1.93077881386314 4.3815389499992e-11 miRNATAP -0.431163587652539 8.99175330979893e-06 NA NA NA hsa-let-7g-3p CACNB4 -1.14091000722297 8.32736018188759e-19 1.93077881386314 4.3815389499992e-11 miRNATAP -0.648123484909163 1.52552095481318e-09 NA NA NA hsa-miR-139-5p CACNB4 -2.11299531796557 8.16407076415038e-28 1.93077881386314 4.3815389499992e-11 miRanda -0.242383497576797 0.000593181239775728 NA NA NA hsa-miR-142-5p CACNB4 -1.44575553250033 1.18797044680592e-13 1.93077881386314 4.3815389499992e-11 mirMAP -0.203202207830953 0.00525745354741346 NA NA NA hsa-miR-144-3p CACNB4 -2.97536914478815 6.00546047309683e-28 1.93077881386314 4.3815389499992e-11 mirMAP -0.142809280455242 0.00448954130966617 NA NA NA hsa-miR-15b-3p CACNB4 0.238105490431193 0.0997721500357416 1.93077881386314 4.3815389499992e-11 mirMAP -0.287403557397674 0.00461607367989603 NA NA NA hsa-miR-16-5p CACNB4 -0.398577235179603 0.000101598495180191 1.93077881386314 4.3815389499992e-11 miRNATAP -0.527924511909205 0.000211822640696663 NA NA NA hsa-miR-195-5p CACNB4 -1.85907534356434 1.47434041676402e-22 1.93077881386314 4.3815389499992e-11 miRNATAP -0.410799179945205 1.0583861816818e-08 NA NA NA hsa-miR-199a-5p CACNB4 -1.98848462405923 2.0421622713753e-11 1.93077881386314 4.3815389499992e-11 miRanda -0.124831270534033 0.00938429701298574 NA NA NA hsa-miR-20a-3p CACNB4 -0.318177901603857 0.0467885456739855 1.93077881386314 4.3815389499992e-11 miRNATAP -0.377521491985471 3.45430717895255e-05 NA NA NA hsa-miR-217 CACNB4 1.05797297540381 0.0401026692682422 1.93077881386314 4.3815389499992e-11 miRanda -0.144250998009545 2.49934687924089e-07 NA NA NA hsa-miR-26a-5p CACNB4 -0.963792031426845 1.83360999387345e-22 1.93077881386314 4.3815389499992e-11 miRNATAP -0.774078447707561 3.00112517123821e-08 NA NA NA hsa-miR-26b-5p CACNB4 -1.10804856399744 4.14176110314282e-22 1.93077881386314 4.3815389499992e-11 miRNAWalker2_validate;miRNATAP -0.415462663708272 0.00063100229337308 NA NA NA hsa-miR-30e-5p CACNB4 -0.627815042856657 3.02205690184908e-10 1.93077881386314 4.3815389499992e-11 mirMAP -0.415609879371581 0.00416054738535645 NA NA NA hsa-miR-330-3p CACNB4 -0.332364259424489 0.0316051913061459 1.93077881386314 4.3815389499992e-11 mirMAP -0.292213174198374 0.00254608498062671 NA NA NA hsa-miR-424-5p CACNB4 -2.62653257498508 2.38997974737991e-50 1.93077881386314 4.3815389499992e-11 miRNATAP -0.407184370467454 1.82523985428203e-08 NA NA NA hsa-miR-497-5p CACNB4 -1.41371173021948 7.09278946477743e-17 1.93077881386314 4.3815389499992e-11 miRNATAP -0.462032497267077 1.73485577916291e-08 NA NA NA hsa-miR-505-3p CACNB4 -1.20027021591555 1.27927500175937e-13 1.93077881386314 4.3815389499992e-11 miRNATAP -0.375240309632655 1.67104721701565e-05 NA NA NA hsa-miR-542-3p CACNB4 -1.31351015149842 3.64642423288576e-22 1.93077881386314 4.3815389499992e-11 miRanda -0.322466347150965 0.00165383873170757 NA NA NA hsa-miR-92a-3p CACNB4 0.212391012518195 0.134292268089997 1.93077881386314 4.3815389499992e-11 mirMAP -0.377241755775004 0.000256879069012096 NA NA NA hsa-let-7b-3p CACNG4 -1.21979213547786 5.84575581584603e-17 1.21398947224201 0.0158504303421043 MirTarget -0.530718908055867 0.00107715515985215 NA NA NA hsa-miR-29a-3p CACNG4 -0.856762511178136 4.65330336378459e-12 1.21398947224201 0.0158504303421043 miRNATAP -0.928996836355232 1.39345739421279e-06 NA NA NA hsa-miR-29c-3p CACNG4 -1.4367517608807 1.61767774905781e-21 1.21398947224201 0.0158504303421043 miRNATAP -0.692310517334316 7.0137294815078e-06 NA NA NA hsa-let-7g-5p CASP3 -0.461294133285527 2.17210114729901e-05 0.309149151776334 0.000465712323457523 MirTarget;miRNATAP -0.107118384912517 0.00693887247949783 NA NA NA hsa-miR-374b-5p CASP3 -0.307538028546424 0.0030079617545972 0.309149151776334 0.000465712323457523 mirMAP -0.143675176440622 0.00057864418465262 NA NA NA hsa-let-7a-5p CDC25B -0.328069937201898 0.000464344093744051 0.802575978153976 1.68584041760539e-08 miRNAWalker2_validate -0.209265115474151 0.00570595808420343 NA NA NA hsa-miR-148a-3p CDC25B -0.748702855596996 3.93313343865641e-07 0.802575978153976 1.68584041760539e-08 miRNAWalker2_validate;miRNATAP -0.29297329943429 2.56785527501486e-10 25341915 Gene CDC25B might be the target gene of miR-148a according to the results of targetscan; CDC25B may be the target gene of miR-148a that plays a role in tumor suppressor gastric cancer hsa-miR-204-5p CDC25B -0.537962150012103 0.0330895493358849 0.802575978153976 1.68584041760539e-08 miRNATAP -0.160852442555331 4.64874282921328e-09 NA NA NA hsa-miR-26b-5p CDC25B -1.10804856399744 4.14176110314282e-22 0.802575978153976 1.68584041760539e-08 miRNAWalker2_validate -0.283705192321105 1.05482202325139e-06 NA NA NA hsa-miR-27b-3p CDC25B -0.823491817819754 9.20935302746823e-14 0.802575978153976 1.68584041760539e-08 miRNATAP -0.298569829692256 1.30532384058526e-06 NA NA NA hsa-miR-15a-5p CHUK 0.349521211668244 0.000770735998804736 -0.19932080126218 0.00863163957240649 miRNAWalker2_validate;miRTarBase;MirTarget -0.122536038974783 0.000565424625908096 NA NA NA hsa-miR-15b-5p CHUK 0.230566941413564 0.0824765001857479 -0.19932080126218 0.00863163957240649 MirTarget -0.118017359725558 2.06238744655946e-05 NA NA NA hsa-miR-16-5p CHUK -0.398577235179603 0.000101598495180191 -0.19932080126218 0.00863163957240649 miRNAWalker2_validate;miRTarBase;MirTarget -0.150607357209835 2.62400382273556e-05 NA NA NA hsa-miR-23a-3p CHUK -0.178875974460574 0.135978273540604 -0.19932080126218 0.00863163957240649 MirTarget -0.100438227795724 0.00114468004476388 NA NA NA hsa-miR-339-5p CHUK 0.280589919878422 0.0355660282647215 -0.19932080126218 0.00863163957240649 miRanda -0.12221351609504 8.92727609693918e-06 NA NA NA hsa-miR-590-5p CHUK -0.103355559980404 0.310027295317092 -0.19932080126218 0.00863163957240649 miRanda -0.11766978557823 0.00128889069327197 NA NA NA hsa-miR-106b-3p CRK 0.304233571120673 0.0118163613572864 -0.66019370420832 1.97619097308481e-10 miRNAWalker2_validate -0.159365409112892 0.000189365619970091 NA NA NA hsa-miR-106b-5p CRK 0.648901865047099 8.24870862047885e-09 -0.66019370420832 1.97619097308481e-10 MirTarget;miRNATAP -0.295615514441088 2.61810886733642e-11 NA NA NA hsa-miR-15b-5p CRK 0.230566941413564 0.0824765001857479 -0.66019370420832 1.97619097308481e-10 miRNAWalker2_validate -0.235313327910405 8.25846095001031e-10 NA NA NA hsa-miR-17-5p CRK 0.698861147045461 2.43854106455398e-05 -0.66019370420832 1.97619097308481e-10 MirTarget;TargetScan;miRNATAP -0.120755318367113 8.74076252625117e-05 NA NA NA hsa-miR-186-5p CRK -0.060103391373687 0.535288717081205 -0.66019370420832 1.97619097308481e-10 miRNATAP -0.252406404381475 2.30776598221014e-06 NA NA NA hsa-miR-20a-5p CRK 0.854326758727003 5.04256669663285e-07 -0.66019370420832 1.97619097308481e-10 MirTarget;miRNATAP -0.120757871328387 5.13100158700272e-05 NA NA NA hsa-miR-20b-5p CRK 0.457668023910379 0.0285865211936156 -0.66019370420832 1.97619097308481e-10 MirTarget;miRNATAP -0.104407248587283 2.00406443364122e-05 NA NA NA hsa-miR-361-5p CRK 0.233202959858696 0.00961572812255327 -0.66019370420832 1.97619097308481e-10 miRanda;mirMAP -0.300388913011588 1.54482122460741e-07 NA NA NA hsa-miR-362-3p CRK 0.814007335895913 2.00108618836568e-09 -0.66019370420832 1.97619097308481e-10 miRanda -0.183183867080247 7.59627311574863e-07 NA NA NA hsa-miR-589-3p CRK 1.16846704028095 5.88525574424201e-11 -0.66019370420832 1.97619097308481e-10 MirTarget -0.182115964896683 1.2359494450309e-10 NA NA NA hsa-miR-93-5p CRK 1.39518349670953 2.84167728726712e-25 -0.66019370420832 1.97619097308481e-10 MirTarget;miRNATAP -0.2647832190801 5.54398293866406e-14 NA NA NA hsa-miR-29a-3p CRKL -0.856762511178136 4.65330336378459e-12 0.104341786609605 0.199462673868753 miRNAWalker2_validate -0.131332728338836 2.20947970885835e-05 NA NA NA hsa-miR-497-5p CRKL -1.41371173021948 7.09278946477743e-17 0.104341786609605 0.199462673868753 MirTarget;miRNATAP -0.108621528190496 9.75730599521659e-07 NA NA NA hsa-miR-335-5p DDIT3 -1.61347836513558 1.62757083289711e-19 0.746820283269726 1.76951274402047e-07 miRNAWalker2_validate -0.12231175702819 0.00119448127382974 NA NA NA hsa-miR-542-3p DDIT3 -1.31351015149842 3.64642423288576e-22 0.746820283269726 1.76951274402047e-07 miRanda -0.143887329825352 0.00367536582810502 NA NA NA hsa-miR-200c-3p DUSP1 -0.104675615392797 0.716957669484981 -2.0215708216874 6.14519109294513e-23 MirTarget;miRNATAP -0.103798077898348 0.00452391050034368 NA NA NA hsa-miR-324-3p DUSP1 0.260348469146494 0.0506141704203545 -2.0215708216874 6.14519109294513e-23 MirTarget -0.524546549499265 1.58226761713942e-11 NA NA NA hsa-miR-331-5p DUSP1 0.213759185384356 0.120772399478646 -2.0215708216874 6.14519109294513e-23 PITA;miRNATAP -0.289891543896133 0.000169691995662819 NA NA NA hsa-miR-425-3p DUSP1 -0.156722391026836 0.223720098459043 -2.0215708216874 6.14519109294513e-23 MirTarget -0.32709277907136 6.7075970426446e-05 NA NA NA hsa-miR-21-5p DUSP10 1.51084295924322 1.54551622173259e-34 -1.25031678861182 9.23323170092562e-16 miRNAWalker2_validate;miRTarBase -0.33582473632279 6.72233513653455e-09 NA NA NA hsa-miR-25-3p DUSP10 0.633062563556379 3.68686354834328e-10 -1.25031678861182 9.23323170092562e-16 MirTarget;miRNATAP -0.317264939016645 3.32405832668753e-05 NA NA NA hsa-miR-421 DUSP10 0.941856334694081 6.12167297054077e-08 -1.25031678861182 9.23323170092562e-16 PITA;miRanda;miRNATAP -0.257801969520221 4.67114837015579e-09 NA NA NA hsa-miR-501-5p DUSP10 1.15231083477882 2.98906150004088e-10 -1.25031678861182 9.23323170092562e-16 PITA;miRNATAP -0.198952445739328 1.87887013008636e-06 NA NA NA hsa-miR-92b-3p DUSP10 0.220374930803974 0.296187538889092 -1.25031678861182 9.23323170092562e-16 MirTarget;miRNATAP -0.134809419236792 0.000285834941831978 NA NA NA hsa-miR-942-5p DUSP10 0.346451845105263 0.0283255399972342 -1.25031678861182 9.23323170092562e-16 MirTarget -0.161205402990724 0.00118151208495541 NA NA NA hsa-miR-589-5p DUSP14 1.18593770505086 1.01781241960531e-22 -0.999998147061491 4.09468318169246e-22 MirTarget -0.157548660186896 0.000152237961473682 NA NA NA hsa-let-7e-5p DUSP16 0.0350298755544731 0.811068614727804 -0.91339878293532 2.52773648393564e-12 miRNATAP -0.13267993420847 0.00300469190779913 NA NA NA hsa-let-7i-5p DUSP16 -0.14267936165213 0.154141689875847 -0.91339878293532 2.52773648393564e-12 miRNATAP -0.201883681224634 0.00216469068708088 NA NA NA hsa-miR-103a-2-5p DUSP16 1.17085533927423 5.31418969120877e-09 -0.91339878293532 2.52773648393564e-12 mirMAP -0.184571682631723 2.56969847420798e-08 NA NA NA hsa-miR-125a-3p DUSP16 -0.841683158494395 3.51202687176603e-05 -0.91339878293532 2.52773648393564e-12 miRanda -0.124338592121423 0.00012521910805357 NA NA NA hsa-miR-140-5p DUSP16 -0.220106443070144 0.0140713197101242 -0.91339878293532 2.52773648393564e-12 miRNATAP -0.196528196162835 0.00766852150721536 NA NA NA hsa-miR-149-5p DUSP16 -0.317176971910036 0.187207559733877 -0.91339878293532 2.52773648393564e-12 miRNATAP -0.130001301129106 1.50556587345142e-06 NA NA NA hsa-miR-224-5p DUSP16 2.67175249172213 1.46995328399796e-18 -0.91339878293532 2.52773648393564e-12 MirTarget -0.114433159809114 1.53140699846969e-08 NA NA NA hsa-miR-320b DUSP16 0.0919652022571331 0.607981643616945 -0.91339878293532 2.52773648393564e-12 MirTarget;miRanda;miRNATAP -0.100986797594047 0.00591779136702622 NA NA NA hsa-miR-339-3p DUSP16 0.3460260703775 0.00865025415274601 -0.91339878293532 2.52773648393564e-12 miRNATAP -0.16341493102637 0.000984789909484414 NA NA NA hsa-miR-342-3p DUSP16 -0.319677314984262 0.0449813878317147 -0.91339878293532 2.52773648393564e-12 miRNATAP -0.217401944913684 7.77819680802501e-08 NA NA NA hsa-miR-361-5p DUSP16 0.233202959858696 0.00961572812255327 -0.91339878293532 2.52773648393564e-12 miRanda -0.255750072670071 0.000467234965816091 NA NA NA hsa-miR-122-5p DUSP2 -1.23907441373955 4.42181244888642e-06 -1.35732553182079 1.42395424664776e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.114497089495435 0.00844174660727719 NA NA NA hsa-miR-93-5p DUSP2 1.39518349670953 2.84167728726712e-25 -1.35732553182079 1.42395424664776e-08 MirTarget;miRNATAP -0.22201299046342 0.00782904743065654 NA NA NA hsa-let-7a-5p DUSP22 -0.328069937201898 0.000464344093744051 0.296163158728697 0.00143409958786832 TargetScan -0.224508113574101 3.32234048377662e-06 NA NA NA hsa-miR-28-5p DUSP22 -0.430964830599964 2.67367257252925e-06 0.296163158728697 0.00143409958786832 miRanda -0.254299216944988 1.9579355309224e-07 NA NA NA hsa-miR-150-5p DUSP3 -1.14624309254329 1.51365525978726e-06 0.0872836900439955 0.276723760000984 miRNATAP -0.101685655816132 1.16739044333681e-10 NA NA NA hsa-miR-15a-5p DUSP3 0.349521211668244 0.000770735998804736 0.0872836900439955 0.276723760000984 MirTarget;miRNATAP -0.145054839460179 0.000105362750446951 NA NA NA hsa-miR-16-5p DUSP3 -0.398577235179603 0.000101598495180191 0.0872836900439955 0.276723760000984 MirTarget;miRNATAP -0.141304741142329 0.00018976179677327 NA NA NA hsa-miR-186-5p DUSP3 -0.060103391373687 0.535288717081205 0.0872836900439955 0.276723760000984 mirMAP -0.121045345794 0.00286455981542574 NA NA NA hsa-miR-197-3p DUSP3 -0.245033899783728 0.0362223947695203 0.0872836900439955 0.276723760000984 mirMAP -0.126642836416922 0.000142137328302017 NA NA NA hsa-miR-3913-5p DUSP3 0.247553671224336 0.062795011081188 0.0872836900439955 0.276723760000984 MirTarget -0.143304346597316 8.68693364412844e-07 NA NA NA hsa-miR-484 DUSP3 0.0857240033709656 0.453982056282229 0.0872836900439955 0.276723760000984 mirMAP -0.127213684962176 0.000193052178236435 NA NA NA hsa-miR-192-3p DUSP4 -0.6401165114007 0.000266272092403814 -0.0822318791590862 0.744228977818766 mirMAP -0.532579059848036 2.48325221024225e-15 NA NA NA hsa-miR-193b-3p DUSP4 -0.166697207281748 0.272022543069482 -0.0822318791590862 0.744228977818766 mirMAP -0.366317447736404 5.34658614685127e-06 NA NA NA hsa-miR-23b-3p DUSP4 -0.530561587109023 5.43807206823652e-07 -0.0822318791590862 0.744228977818766 mirMAP -0.851703217775624 2.78456018281722e-14 NA NA NA hsa-miR-30b-3p DUSP4 -0.439724365151373 0.000947180503583586 -0.0822318791590862 0.744228977818766 MirTarget -0.376703317831252 3.97568819855911e-05 NA NA NA hsa-miR-616-5p DUSP4 0.150569904638223 0.402836556304524 -0.0822318791590862 0.744228977818766 mirMAP -0.211276111660806 0.00201426718614318 NA NA NA hsa-miR-664a-3p DUSP4 0.485807855553031 0.000732553249798598 -0.0822318791590862 0.744228977818766 mirMAP -0.357114554549855 2.43382220707369e-05 NA NA NA hsa-miR-107 DUSP5 0.241662461253461 0.0170788899505389 -1.95138767026502 9.15660987178973e-20 miRanda -0.698390995230913 6.17312793398798e-11 NA NA NA hsa-miR-23b-3p DUSP5 -0.530561587109023 5.43807206823652e-07 -1.95138767026502 9.15660987178973e-20 MirTarget;miRNATAP -0.333730703469697 0.00117235468007835 NA NA NA hsa-miR-25-3p DUSP5 0.633062563556379 3.68686354834328e-10 -1.95138767026502 9.15660987178973e-20 MirTarget;miRNATAP -0.377035423742957 0.000419539062126491 NA NA NA hsa-miR-32-5p DUSP5 0.0806126674664016 0.548984992497432 -1.95138767026502 9.15660987178973e-20 MirTarget;miRNATAP -0.264232226038465 0.00123465050517087 NA NA NA hsa-miR-548b-3p DUSP5 -0.0203576084717134 0.930819503166956 -1.95138767026502 9.15660987178973e-20 miRNATAP -0.186848390080206 7.48984460615939e-05 NA NA NA hsa-miR-106a-5p DUSP8 -0.464229535269236 0.009724944358047 0.597479289630443 0.00290374045782047 MirTarget;miRNATAP -0.159548888632042 0.00344747833975406 NA NA NA hsa-miR-20b-5p DUSP8 0.457668023910379 0.0285865211936156 0.597479289630443 0.00290374045782047 MirTarget;miRNATAP -0.177462429238997 0.000144067841699229 NA NA NA hsa-miR-30a-3p DUSP8 -1.52720594401486 1.3830066075708e-17 0.597479289630443 0.00290374045782047 MirTarget;miRNATAP -0.150659304173616 0.00423145581646127 NA NA NA hsa-miR-30e-3p DUSP8 -1.20845647373031 3.10263633528203e-25 0.597479289630443 0.00290374045782047 MirTarget -0.248214978279189 0.00183389795709673 NA NA NA hsa-let-7a-5p DUSP9 -0.328069937201898 0.000464344093744051 3.1269142024265 1.25405437803303e-16 TargetScan;miRNATAP -0.734018037050491 0.000344246692768342 NA NA NA hsa-let-7b-5p DUSP9 -0.959013717270803 5.95127281258643e-11 3.1269142024265 1.25405437803303e-16 miRNATAP -0.67382263873815 9.82794071016697e-08 NA NA NA hsa-let-7g-5p DUSP9 -0.461294133285527 2.17210114729901e-05 3.1269142024265 1.25405437803303e-16 miRNATAP -0.829738575372315 2.00228651764064e-06 NA NA NA hsa-miR-100-5p DUSP9 -0.783576782126614 0.000219958772262677 3.1269142024265 1.25405437803303e-16 mirMAP -0.656773081946067 4.7136096252303e-14 NA NA NA hsa-miR-30a-3p DUSP9 -1.52720594401486 1.3830066075708e-17 3.1269142024265 1.25405437803303e-16 MirTarget -0.937101643944058 9.8983435320316e-22 NA NA NA hsa-miR-30e-3p DUSP9 -1.20845647373031 3.10263633528203e-25 3.1269142024265 1.25405437803303e-16 MirTarget -1.10680137089383 2.71696369140324e-13 NA NA NA hsa-miR-542-3p DUSP9 -1.31351015149842 3.64642423288576e-22 3.1269142024265 1.25405437803303e-16 miRanda -0.608805667194702 4.90416544271772e-06 NA NA NA hsa-miR-99a-5p DUSP9 -1.51481656384839 3.93230057259529e-14 3.1269142024265 1.25405437803303e-16 mirMAP -0.717445128410628 1.12779438331928e-15 NA NA NA hsa-miR-142-3p ECSIT -1.4243101967815 1.92609481097765e-14 -0.179440662411703 0.0686940979012651 miRanda -0.127083283383557 2.53850519158648e-07 NA NA NA hsa-miR-146a-5p EGFR -0.742958238440575 0.000765983177482633 -1.01672920195188 6.69873186671412e-07 miRNAWalker2_validate -0.224421920698198 6.22524592924969e-07 24895573;25242818;22161865;25596948;25417703;23555954;24839931;21632853 Furthermore western blot showed that miR-146a mimic downregulated EGFR ERK1/2 and stat5 signalings; These effects were less potent compared to that of a siRNA targeting EGFR a known target gene of miR-146a; Moreover miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents;Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;MiR 146a suppresses tumor growth and progression by targeting EGFR pathway and in a p ERK dependent manner in castration resistant prostate cancer; Mechanistic studies revealed that miR-146a repressed the expression of EGFR through binding to its 3'-untranslated region; Our findings suggest that ubiquitous loss of miR-146a is a critical mechanism for overexpression of EGFR in CRPC which is crucial to better understanding the pathogenesis of CRPC;Furthermore the expressions of bax and cleaved-caspase-3 mainly were increased in control and overexpression miR-146a groups however the expression of EGFR was inverse; All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells which was performed by up-regulating miR-146a expression then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways and inhibiting invasion through down-regulating the expression of EGFR;Here we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a; We show that BRCA1 binds to MIR146A promoter and activates transcription which in turn attenuates EGFR expression;In functional experiments miR-146a suppressed cell growth induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines H358 H1650 H1975 HCC827 and H292 miR-146a also inhibited the migratory capacity of these NSCLC cells; On the other hand miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR including both TKIs gefitinib erlotinib and afatinib and a monoclonal antibody cetuximab; Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling;Deregulation of miR 146a expression in a mouse model of pancreatic cancer affecting EGFR signaling; Treatment of PC cells with CDF a novel synthetic compound led to re-expression of miR-146a resulting in the down-regulation of EGFR expression; Further knock-down of miR-146a in AsPC-1 cells led to the up-regulation of EGFR expression and showed increased clonogenic growth; In addition knock-down of EGFR by EGFR siRNA transfection of parental AsPC-1 cells and AsPC-1 cells stably transfected with pre-miR-146a resulted in decreased invasive capacity which was further confirmed by reduced luciferase activity in cells transfected with pMIR-Luc reporter vector containing miR-146a binding site; Collectively these results suggest that the loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling and that re-expression of miR-146a by CDF treatment could be useful in designing personalized strategy for the treatment of human PC;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;;progression;;;;; liver cancer;pancreatic cancer;prostate cancer;breast cancer;breast cancer;lung squamous cell cancer;pancreatic cancer;gastric cancer hsa-miR-146b-5p EGFR 0.419719546795449 0.0457375823220155 -1.01672920195188 6.69873186671412e-07 miRNATAP -0.221138858293073 3.44879306513365e-06 NA NA NA hsa-miR-148b-5p EGFR 0.295777213389605 0.0255749859535438 -1.01672920195188 6.69873186671412e-07 mirMAP -0.233539600600063 0.00227279523782391 NA NA NA hsa-miR-17-5p EGFR 0.698861147045461 2.43854106455398e-05 -1.01672920195188 6.69873186671412e-07 TargetScan -0.161590563481239 0.00764134099999989 NA NA NA hsa-miR-188-5p EGFR 1.11646899351496 9.56686958408598e-11 -1.01672920195188 6.69873186671412e-07 mirMAP -0.300235014857475 1.22424681244032e-07 NA NA NA hsa-miR-21-5p EGFR 1.51084295924322 1.54551622173259e-34 -1.01672920195188 6.69873186671412e-07 miRNAWalker2_validate;miRTarBase -0.440371363258275 3.21604130567409e-09 24198203;20113523;24012640;24331411;26563758;19597153;26026961;20048743 In radically resected NSCLC patients the expression levels of miR-21 10b in patients with EGFR mutation were much higher than those without mutation;Thus the miR-21 inhibitor might interrupt the activity of EGFR pathways independently of PTEN status;Further the expression of miR-21 is regulated by EGFR via the activation of β-catenin and AP-1; These data indicate that a feedback loop exists between miR-21 and EGFR; These results clarify a novel association between miR-21 and EGFR in the regulation of cancer cell progression;MiR 21 overexpression is associated with acquired resistance of EGFR TKI in non small cell lung cancer;Higher expression levels of miR-21 AmiR-27a and miR-218 detected in this study suggest potential roles of these miRNAs in primary resistance to EGFR-TKI in advanced NSCLC patients with EGFR exon 19 deletion mutations;MiR 21 is an EGFR regulated anti apoptotic factor in lung cancer in never smokers; The changes in expression of some of these miRNAs including miR-21 were more remarkable in cases with EGFR mutations than in those without these mutations; In the never-smoker-derived lung adenocarcinoma cell line H3255 with mutant EGFR and high levels of p-EGFR and miR-21 antisense inhibition of miR-21 enhanced AG1478-induced apoptosis; In a never-smoker-derived adenocarcinoma cell line H441 with wild-type EGFR the antisense miR-21 not only showed the additive effect with AG1478 but also induced apoptosis by itself; These results suggest that aberrantly increased expression of miR-21 which is enhanced further by the activated EGFR signaling pathway plays a significant role in lung carcinogenesis in never-smokers as well as in smokers and is a potential therapeutic target in both EGFR-mutant and wild-type cases;Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR mutated lung cancer via nickel induced microRNA 21 expression;Downregulation of miR 21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status ;;progression;drug resistance;staging;drug resistance;tumorigenesis;; lung squamous cell cancer;glioblastoma;glioblastoma;lung squamous cell cancer;lung squamous cell cancer;lung cancer;lung cancer;glioblastoma hsa-miR-29a-5p EGFR -0.113555908626946 0.349622266470788 -1.01672920195188 6.69873186671412e-07 mirMAP -0.458889085026057 2.82252978142708e-08 27477273 Feedback Loop Regulation of SCAP/SREBP 1 by miR 29 Modulates EGFR Signaling Driven Glioblastoma Growth glioblastoma hsa-miR-32-3p EGFR 0.219109440121582 0.207217051619543 -1.01672920195188 6.69873186671412e-07 mirMAP -0.238124126347676 6.9947851263588e-05 NA NA NA hsa-miR-362-5p EGFR 0.717921690799312 1.68392734504524e-05 -1.01672920195188 6.69873186671412e-07 mirMAP -0.247853042376492 3.33470814837779e-05 NA NA NA hsa-miR-374b-3p EGFR -0.137420230218985 0.305318192448799 -1.01672920195188 6.69873186671412e-07 mirMAP -0.202869152527087 0.00750806275200147 NA NA NA hsa-miR-455-5p EGFR -0.270546034117157 0.0581320703577731 -1.01672920195188 6.69873186671412e-07 miRanda -0.226922724788645 0.00135818927133814 NA NA NA hsa-miR-501-5p EGFR 1.15231083477882 2.98906150004088e-10 -1.01672920195188 6.69873186671412e-07 mirMAP -0.228828416518186 2.10663471825952e-05 NA NA NA hsa-miR-590-5p EGFR -0.103355559980404 0.310027295317092 -1.01672920195188 6.69873186671412e-07 miRanda;mirMAP -0.282971808483034 0.00478577902454241 NA NA NA hsa-miR-769-5p EGFR 0.219661452072771 0.0333425465750576 -1.01672920195188 6.69873186671412e-07 mirMAP -0.501593765874938 2.76004531715872e-07 NA NA NA hsa-miR-877-5p EGFR 1.35669625926821 1.43008125755656e-11 -1.01672920195188 6.69873186671412e-07 mirMAP -0.247141034396675 1.1588258665615e-06 NA NA NA hsa-miR-17-5p ELK4 0.698861147045461 2.43854106455398e-05 0.23519596686873 0.0267189511596387 TargetScan;miRNATAP -0.154076598507706 5.01139342395465e-07 NA NA NA hsa-miR-19a-3p ELK4 1.01712596153672 2.57753201450625e-07 0.23519596686873 0.0267189511596387 mirMAP -0.118824673208507 3.45685336125229e-06 NA NA NA hsa-miR-19b-3p ELK4 0.601279551368824 0.00016685097085251 0.23519596686873 0.0267189511596387 mirMAP -0.150861509627552 2.28615934127865e-06 NA NA NA hsa-miR-20a-5p ELK4 0.854326758727003 5.04256669663285e-07 0.23519596686873 0.0267189511596387 miRNATAP -0.130494503212055 1.21344676733769e-05 NA NA NA hsa-miR-21-3p ELK4 -0.484219378716006 0.00299941098417659 0.23519596686873 0.0267189511596387 mirMAP -0.106868781896012 0.000704209163548549 NA NA NA hsa-miR-30b-5p ELK4 -0.54056186708617 2.44688760798341e-05 0.23519596686873 0.0267189511596387 mirMAP -0.126803765220563 0.0015757498127986 NA NA NA hsa-miR-342-3p ELK4 -0.319677314984262 0.0449813878317147 0.23519596686873 0.0267189511596387 mirMAP -0.179848305794823 1.89051279790818e-08 NA NA NA hsa-miR-362-5p ELK4 0.717921690799312 1.68392734504524e-05 0.23519596686873 0.0267189511596387 mirMAP -0.108163310521444 0.000416360248918572 NA NA NA hsa-miR-450b-5p ELK4 -1.34333360369432 2.68386079790462e-17 0.23519596686873 0.0267189511596387 mirMAP;miRNATAP -0.102994422000307 0.000982510551085411 NA NA NA hsa-miR-500a-5p ELK4 0.797906382969156 9.15958171084226e-08 0.23519596686873 0.0267189511596387 mirMAP -0.11199760707748 0.00102424350854521 NA NA NA hsa-miR-590-5p ELK4 -0.103355559980404 0.310027295317092 0.23519596686873 0.0267189511596387 mirMAP -0.167036035754035 0.00111274408929524 NA NA NA hsa-miR-92a-3p ELK4 0.212391012518195 0.134292268089997 0.23519596686873 0.0267189511596387 mirMAP -0.164514774042279 5.8122332804161e-06 NA NA NA hsa-miR-106a-5p FAS -0.464229535269236 0.009724944358047 -1.01888565147264 1.11378826495697e-07 miRNAWalker2_validate;miRTarBase -0.302797529669468 5.79007536295077e-09 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-21-5p FAS 1.51084295924322 1.54551622173259e-34 -1.01888565147264 1.11378826495697e-07 miRNAWalker2_validate -0.345881974093154 8.950367188801e-07 24710931 miR 21 targets Fas ligand mediated apoptosis in breast cancer cell line MCF 7 breast cancer hsa-miR-338-3p FAS 0.543135607704581 0.00461167747143826 -1.01888565147264 1.11378826495697e-07 miRanda -0.23029320652752 2.57971450360388e-06 NA NA NA hsa-miR-361-5p FAS 0.233202959858696 0.00961572812255327 -1.01888565147264 1.11378826495697e-07 miRanda -0.400344969968845 0.000164688479523076 NA NA NA hsa-miR-590-5p FAS -0.103355559980404 0.310027295317092 -1.01888565147264 1.11378826495697e-07 miRanda -0.564263807321375 1.14802968070722e-09 NA NA NA hsa-miR-98-5p FAS -0.0487189107419432 0.715911066732548 -1.01888565147264 1.11378826495697e-07 miRNAWalker2_validate -0.184416097033268 0.00981276415174906 NA NA NA hsa-miR-25-3p FASLG 0.633062563556379 3.68686354834328e-10 -0.789267794109529 0.000910923617828174 miRNATAP -0.409147266425705 0.000319496225971281 NA NA NA hsa-miR-16-1-3p FGF1 0.392360028038559 0.00112481918108198 -0.678542882304208 0.00654328337233827 mirMAP -0.418480509125599 3.32517568843891e-05 NA NA NA hsa-miR-186-5p FGF1 -0.060103391373687 0.535288717081205 -0.678542882304208 0.00654328337233827 mirMAP -0.41367102247344 0.00114927327556726 NA NA NA hsa-miR-18a-5p FGF1 0.918028187958706 1.90229510425322e-05 -0.678542882304208 0.00654328337233827 MirTarget -0.257554404550762 3.95122313648269e-06 NA NA NA hsa-miR-361-5p FGF1 0.233202959858696 0.00961572812255327 -0.678542882304208 0.00654328337233827 miRanda -0.510174670094289 0.000185533193035221 NA NA NA hsa-miR-550a-5p FGF1 0.156224023171823 0.282505553619229 -0.678542882304208 0.00654328337233827 MirTarget -0.374323243103714 7.86437510357121e-06 NA NA NA hsa-miR-576-5p FGF1 -0.377452008285847 0.00470735657343984 -0.678542882304208 0.00654328337233827 PITA;mirMAP -0.266396057997619 0.00356602502679197 NA NA NA hsa-miR-590-5p FGF1 -0.103355559980404 0.310027295317092 -0.678542882304208 0.00654328337233827 MirTarget;miRanda;miRNATAP -0.467961306585168 0.000104595555173684 NA NA NA hsa-miR-193b-3p FGF11 -0.166697207281748 0.272022543069482 0.213353925569267 0.274831508108713 miRNAWalker2_validate -0.200531716988523 0.00140906192264391 NA NA NA hsa-miR-28-5p FGF11 -0.430964830599964 2.67367257252925e-06 0.213353925569267 0.274831508108713 miRanda -0.376056857807372 0.00027660131559535 NA NA NA hsa-miR-548b-3p FGF11 -0.0203576084717134 0.930819503166956 0.213353925569267 0.274831508108713 mirMAP -0.150043977025028 0.00025412409602433 NA NA NA hsa-miR-17-5p FGF12 0.698861147045461 2.43854106455398e-05 1.12701565396445 0.000125070474588253 TargetScan -0.353312293407124 4.00239309386818e-05 NA NA NA hsa-miR-200b-3p FGF12 -1.29335788099229 0.000268623234305059 1.12701565396445 0.000125070474588253 TargetScan -0.167486025000735 2.91497216782912e-05 NA NA NA hsa-miR-429 FGF12 -1.40262535827285 6.93982219171912e-05 1.12701565396445 0.000125070474588253 miRNATAP -0.176507119934699 1.51329896482206e-05 NA NA NA hsa-miR-455-5p FGF12 -0.270546034117157 0.0581320703577731 1.12701565396445 0.000125070474588253 miRanda -0.2955118739476 0.00352688948327299 NA NA NA hsa-miR-483-3p FGF12 -2.99328900859484 2.67538108509603e-07 1.12701565396445 0.000125070474588253 PITA -0.119968404362397 8.50806205124405e-07 NA NA NA hsa-miR-889-3p FGF12 -0.704721025765331 0.0139978010941786 1.12701565396445 0.000125070474588253 MirTarget -0.131935954446475 0.00860562658075859 NA NA NA hsa-miR-455-5p FGF13 -0.270546034117157 0.0581320703577731 1.04387202836938 0.000243713997792116 PITA;miRanda -0.315950161217624 0.00124978729248725 NA NA NA hsa-miR-193a-5p FGF14 -0.472805720224262 1.24962968905481e-05 -0.650638914328184 0.0386566233872504 TargetScan -0.396389198365541 0.00514712574405294 NA NA NA hsa-miR-362-3p FGF14 0.814007335895913 2.00108618836568e-09 -0.650638914328184 0.0386566233872504 miRanda -0.296503371024151 0.00779105168383237 NA NA NA hsa-miR-421 FGF14 0.941856334694081 6.12167297054077e-08 -0.650638914328184 0.0386566233872504 miRanda -0.459990027128502 9.7647751856669e-08 NA NA NA hsa-miR-15b-3p FGF2 0.238105490431193 0.0997721500357416 -1.08625533231299 0.000324809942833161 mirMAP -0.499213807743807 9.41955107470528e-07 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 0.230566941413564 0.0824765001857479 -1.08625533231299 0.000324809942833161 MirTarget;miRNATAP -0.306809751282981 0.00622064491645458 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-2-3p FGF2 -0.0336420826463706 0.805158952566973 -1.08625533231299 0.000324809942833161 mirMAP -0.422467965590387 0.000103679884556575 NA NA NA hsa-miR-181a-5p FGF2 0.250113435902954 0.0551933249319293 -1.08625533231299 0.000324809942833161 mirMAP -0.406045352280239 0.000358497143826792 NA NA NA hsa-miR-181b-5p FGF2 0.488256489401108 0.00105321129419701 -1.08625533231299 0.000324809942833161 mirMAP -0.523910277677257 9.1015168945214e-08 NA NA NA hsa-miR-19b-1-5p FGF2 -0.277804782598538 0.0783067794722916 -1.08625533231299 0.000324809942833161 mirMAP -0.529151998934904 1.16181517704286e-08 NA NA NA hsa-miR-200b-3p FGF2 -1.29335788099229 0.000268623234305059 -1.08625533231299 0.000324809942833161 mirMAP -0.168899172593471 4.11351056555817e-05 NA NA NA hsa-miR-200c-3p FGF2 -0.104675615392797 0.716957669484981 -1.08625533231299 0.000324809942833161 mirMAP -0.156084549253076 0.00233819769179705 NA NA NA hsa-miR-20a-3p FGF2 -0.318177901603857 0.0467885456739855 -1.08625533231299 0.000324809942833161 mirMAP -0.492065243098747 8.09310422865092e-08 NA NA NA hsa-miR-21-3p FGF2 -0.484219378716006 0.00299941098417659 -1.08625533231299 0.000324809942833161 mirMAP -0.240197113439825 0.00811114129230132 NA NA NA hsa-miR-21-5p FGF2 1.51084295924322 1.54551622173259e-34 -1.08625533231299 0.000324809942833161 mirMAP -0.443381765546842 5.91228766084995e-05 NA NA NA hsa-miR-217 FGF2 1.05797297540381 0.0401026692682422 -1.08625533231299 0.000324809942833161 miRanda -0.127490520581258 7.38698652450206e-06 NA NA NA hsa-miR-335-3p FGF2 -0.275199247483111 0.106629165248783 -1.08625533231299 0.000324809942833161 mirMAP -0.405107692314837 2.67658505476485e-06 NA NA NA hsa-miR-338-5p FGF2 -0.221898432884726 0.252390988727086 -1.08625533231299 0.000324809942833161 mirMAP -0.277477917380717 0.000298421894309671 NA NA NA hsa-miR-429 FGF2 -1.40262535827285 6.93982219171912e-05 -1.08625533231299 0.000324809942833161 mirMAP -0.192074793475977 4.45604159403906e-06 NA NA NA hsa-miR-452-5p FGF2 1.91544498799508 1.81995982853313e-14 -1.08625533231299 0.000324809942833161 mirMAP -0.254292038125162 7.84361502048493e-06 NA NA NA hsa-miR-589-3p FGF2 1.16846704028095 5.88525574424201e-11 -1.08625533231299 0.000324809942833161 mirMAP -0.346323302130209 2.68946343007257e-05 NA NA NA hsa-miR-92a-3p FGF2 0.212391012518195 0.134292268089997 -1.08625533231299 0.000324809942833161 miRNAWalker2_validate -0.635934402042256 6.72536311164143e-10 NA NA NA hsa-miR-93-3p FGF2 0.402821129107592 0.00131324842735588 -1.08625533231299 0.000324809942833161 mirMAP -0.437085459323848 0.000209985380897254 NA NA NA hsa-miR-107 FGF7 0.241662461253461 0.0170788899505389 -0.653895802717462 0.00602323864930533 PITA;miRanda;miRNATAP -0.317347847907002 0.0061558373813029 NA NA NA hsa-miR-15a-5p FGF7 0.349521211668244 0.000770735998804736 -0.653895802717462 0.00602323864930533 miRTarBase;miRNATAP -0.366019587762154 0.00111409761072969 NA NA NA hsa-miR-15b-5p FGF7 0.230566941413564 0.0824765001857479 -0.653895802717462 0.00602323864930533 miRNATAP -0.392337856862938 7.12966084973613e-06 NA NA NA hsa-miR-16-1-3p FGF7 0.392360028038559 0.00112481918108198 -0.653895802717462 0.00602323864930533 mirMAP -0.272657830128381 0.00482946390365832 NA NA NA hsa-miR-20a-5p FGF7 0.854326758727003 5.04256669663285e-07 -0.653895802717462 0.00602323864930533 miRNAWalker2_validate -0.341470101333498 3.32475785382172e-07 NA NA NA hsa-miR-361-5p FGF7 0.233202959858696 0.00961572812255327 -0.653895802717462 0.00602323864930533 PITA;miRanda;miRNATAP -0.415294917437999 0.00146403039846296 NA NA NA hsa-miR-421 FGF7 0.941856334694081 6.12167297054077e-08 -0.653895802717462 0.00602323864930533 miRanda -0.230227109673969 0.000489381552238336 NA NA NA hsa-miR-455-3p FGF7 -1.3998033821095 5.72010709806871e-17 -0.653895802717462 0.00602323864930533 PITA;miRNATAP -0.173570787405519 0.00961793201913047 NA NA NA hsa-miR-590-5p FGF7 -0.103355559980404 0.310027295317092 -0.653895802717462 0.00602323864930533 PITA;miRanda -0.57199782619933 5.74241805880331e-07 NA NA NA hsa-miR-616-5p FGF7 0.150569904638223 0.402836556304524 -0.653895802717462 0.00602323864930533 mirMAP -0.245435969787053 0.000149305105460564 NA NA NA hsa-miR-618 FGF7 0.13539895350352 0.517145913114103 -0.653895802717462 0.00602323864930533 mirMAP -0.227583154837617 7.48998921932753e-05 NA NA NA hsa-miR-106b-5p FGFR1 0.648901865047099 8.24870862047885e-09 -1.10351511026112 4.12675064572266e-07 mirMAP -0.284443073679231 0.0026248045594602 NA NA NA hsa-miR-15a-5p FGFR1 0.349521211668244 0.000770735998804736 -1.10351511026112 4.12675064572266e-07 miRNATAP -0.352840830794253 0.000677757595811867 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 0.698861147045461 2.43854106455398e-05 -1.10351511026112 4.12675064572266e-07 mirMAP -0.237393252177173 0.000224064428361276 NA NA NA hsa-miR-20a-5p FGFR1 0.854326758727003 5.04256669663285e-07 -1.10351511026112 4.12675064572266e-07 mirMAP -0.287282538249605 3.68706352846777e-06 NA NA NA hsa-miR-361-5p FGFR1 0.233202959858696 0.00961572812255327 -1.10351511026112 4.12675064572266e-07 miRanda -0.33530909970249 0.00556370932111968 NA NA NA hsa-miR-455-5p FGFR1 -0.270546034117157 0.0581320703577731 -1.10351511026112 4.12675064572266e-07 miRanda -0.249494978181263 0.000949827332507152 NA NA NA hsa-miR-532-5p FGFR1 1.02729546510601 9.93318913966636e-16 -1.10351511026112 4.12675064572266e-07 PITA -0.504576508830531 2.82854123723416e-10 NA NA NA hsa-miR-93-5p FGFR1 1.39518349670953 2.84167728726712e-25 -1.10351511026112 4.12675064572266e-07 mirMAP -0.326905735165641 1.37221347364255e-05 NA NA NA hsa-miR-107 FGFR2 0.241662461253461 0.0170788899505389 -2.28582334954307 1.14765468936708e-05 PITA;miRanda -0.690301810710163 0.0068857261082219 NA NA NA hsa-miR-100-5p FGFR3 -0.783576782126614 0.000219958772262677 0.189024805500786 0.340204942325551 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.269596147351536 1.27205852375091e-09 25344675;26604796;26018508;23778527 MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3;Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress ;;;poor survival pancreatic cancer;glioblastoma;sarcoma;bladder cancer hsa-miR-99a-5p FGFR3 -1.51481656384839 3.93230057259529e-14 0.189024805500786 0.340204942325551 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.302096873169716 3.68370160731018e-11 23409016;24456664;23298836 Photofrin based photodynamic therapy and miR 99a transfection inhibited FGFR3 and PI3K/Akt signaling mechanisms to control growth of human glioblastoma In vitro and in vivo; Further photofrin based PDT followed by miR-99a transfection dramatically increased miR-99a expression and also increased apoptosis in glioblastoma cell cultures and drastically reduced tumor growth in athymic nude mice due to down regulation of fibroblast growth factor receptor 3 FGFR3 and PI3K/Akt signaling mechanisms leading to inhibition of cell proliferation and induction of molecular mechanisms of apoptosis;miR 99a promotes proliferation targeting FGFR3 in human epithelial ovarian cancer cells; Importantly fibroblast growth factor receptor 3 FGFR3 predicted to be one target gene of miR-99a using computational algorithms was higher in expression in EOC cells; Subsequently FGFR3 was proved to be direct target of miR-99a by dual luciferase assay; Furthermore overexpression of miR-99a dramatically suppressed expression level of FGFR3 at both mRNA and protein levels proving FGFR3 to be inversely correlated with miR-99a; Finally overexpression of miR-99a could significantly inhibit EOC cell proliferation in vitro by decreasing the expression of FGFR3 which also reduced the EOC cell growth after siRNA knockdown; Conclusively miR-99a expression was remarkably downregulated in serums tissues and cell and suppresses EOC cell proliferation by targeting FGFR3 suggesting miR-99a as a prospective prognosis marker and potential tumor suppressor for EOC therapeutics;The tumorigenic FGFR3 TACC3 gene fusion escapes miR 99a regulation in glioblastoma; The fusion caused by tandem duplication on 4p16.3 led to the loss of the 3'-UTR of FGFR3 blocking gene regulation of miR-99a and enhancing expression of the fusion gene ;worse prognosis; glioblastoma;ovarian cancer;glioblastoma hsa-miR-326 FGFR4 -1.881935132554 1.68087316863775e-21 0.491652034961419 0.019783553566567 miRanda;miRNATAP -0.275615867301029 2.26792389115162e-08 NA NA NA hsa-miR-491-5p FGFR4 -0.369122930844418 0.0154047757048929 0.491652034961419 0.019783553566567 miRanda -0.246783584450743 0.000288636596057226 NA NA NA hsa-miR-193b-3p FLNA -0.166697207281748 0.272022543069482 0.227340527470956 0.203430797039815 miRNAWalker2_validate -0.255056648016732 8.03407035240961e-06 NA NA NA hsa-miR-20a-5p FLNA 0.854326758727003 5.04256669663285e-07 0.227340527470956 0.203430797039815 miRNAWalker2_validate -0.238395501979443 1.97781492413483e-06 NA NA NA hsa-miR-23b-3p FLNA -0.530561587109023 5.43807206823652e-07 0.227340527470956 0.203430797039815 miRNAWalker2_validate -0.280105210478808 0.00059922753549396 24443580 Kaplan-Meier and multivariate analysis showed a significant association with tumour relapses for miR-23b and with tumour-specific death for miR-150 in PD and oPD thyroid carcinomas thyroid cancer hsa-miR-378a-3p FLNA -1.1920055906972 3.23538871733634e-10 0.227340527470956 0.203430797039815 miRNAWalker2_validate -0.197252838282232 9.82760832497973e-06 NA NA NA hsa-miR-92a-3p FLNA 0.212391012518195 0.134292268089997 0.227340527470956 0.203430797039815 miRNAWalker2_validate -0.313354262288746 2.67776037776007e-07 NA NA NA hsa-miR-22-5p FLNB -0.630365901263172 3.32415348030414e-05 0.0616115905537233 0.47409603567942 mirMAP -0.158444011355472 3.66758491148787e-09 NA NA NA hsa-miR-484 FLNB 0.0857240033709656 0.453982056282229 0.0616115905537233 0.47409603567942 miRNAWalker2_validate -0.101940005037448 0.00554009515568312 NA NA NA hsa-miR-455-5p FLNC -0.270546034117157 0.0581320703577731 1.11832216142873 0.00729726825244788 miRanda -0.448018525003576 0.00172675169218686 NA NA NA hsa-miR-221-3p FOS 1.12244756358612 3.48370308238012e-13 -3.63859914445361 9.27794861825719e-37 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.561899061238752 3.60354241869353e-09 NA NA NA hsa-miR-222-3p FOS 1.08574156066353 1.76407192348131e-11 -3.63859914445361 9.27794861825719e-37 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.444477688664767 1.35122650868218e-06 NA NA NA hsa-miR-361-5p FOS 0.233202959858696 0.00961572812255327 -3.63859914445361 9.27794861825719e-37 miRanda -0.476736113148367 0.0056702939798263 NA NA NA hsa-miR-362-3p FOS 0.814007335895913 2.00108618836568e-09 -3.63859914445361 9.27794861825719e-37 miRanda -0.383155598069896 0.000558081419260013 NA NA NA hsa-miR-501-3p FOS 0.999540908940094 2.77358485581974e-11 -3.63859914445361 9.27794861825719e-37 MirTarget;PITA;miRNATAP -0.48143879247508 1.16989536284298e-06 NA NA NA hsa-miR-502-3p FOS 0.659598854007546 3.01316453996423e-08 -3.63859914445361 9.27794861825719e-37 MirTarget;PITA;miRNATAP -0.626659548252717 6.96731546239833e-07 NA NA NA hsa-miR-589-3p FOS 1.16846704028095 5.88525574424201e-11 -3.63859914445361 9.27794861825719e-37 MirTarget -0.466742475706238 3.64210815757719e-08 NA NA NA hsa-miR-148b-3p GADD45A 0.266862251671911 0.00185271302045935 -1.18438355981419 2.04421074395418e-12 MirTarget -0.53346134919236 5.63428920227987e-08 NA NA NA hsa-miR-301a-3p GADD45A 0.842910511640361 1.43446467417891e-06 -1.18438355981419 2.04421074395418e-12 MirTarget;miRNATAP -0.429003570363722 3.99121895415153e-21 NA NA NA hsa-miR-324-5p GADD45A 0.372933276649782 0.00592280066108904 -1.18438355981419 2.04421074395418e-12 miRanda -0.518772278708973 4.69587473312867e-18 NA NA NA hsa-miR-331-5p GADD45A 0.213759185384356 0.120772399478646 -1.18438355981419 2.04421074395418e-12 PITA;miRNATAP -0.430187189615618 9.35766561284238e-13 NA NA NA hsa-miR-421 GADD45A 0.941856334694081 6.12167297054077e-08 -1.18438355981419 2.04421074395418e-12 miRanda -0.399146316642953 4.95904028323981e-18 NA NA NA hsa-miR-429 GADD45A -1.40262535827285 6.93982219171912e-05 -1.18438355981419 2.04421074395418e-12 miRNATAP -0.147502825337448 3.86036414101022e-10 NA NA NA hsa-miR-454-3p GADD45A 0.668749059573955 2.42670710515113e-06 -1.18438355981419 2.04421074395418e-12 MirTarget;miRNATAP -0.336757743574097 6.70178941647605e-09 NA NA NA hsa-miR-500a-5p GADD45A 0.797906382969156 9.15958171084226e-08 -1.18438355981419 2.04421074395418e-12 MirTarget;miRNATAP -0.380400118148641 2.78037785058895e-12 NA NA NA hsa-miR-500b-5p GADD45A 0.79864276129988 8.80934488971056e-08 -1.18438355981419 2.04421074395418e-12 MirTarget -0.380385448906191 2.83925177775155e-12 NA NA NA hsa-miR-502-5p GADD45A 0.892373335336396 1.7122694518919e-06 -1.18438355981419 2.04421074395418e-12 MirTarget;PITA;miRNATAP -0.211861066175866 2.8783697640044e-06 NA NA NA hsa-miR-324-3p GADD45B 0.260348469146494 0.0506141704203545 -2.18315196507153 1.75545549044514e-24 MirTarget;miRNATAP -0.489337683262879 2.36967761576399e-09 NA NA NA hsa-miR-181a-5p GADD45G 0.250113435902954 0.0551933249319293 -1.8078339802055 7.96436141465682e-13 miRNAWalker2_validate -0.541338211358986 1.77478587318898e-08 NA NA NA hsa-miR-320a GADD45G 0.325285936317332 0.0221415065838824 -1.8078339802055 7.96436141465682e-13 miRanda -0.463178177312941 1.50939059891479e-07 NA NA NA hsa-miR-320b GADD45G 0.0919652022571331 0.607981643616945 -1.8078339802055 7.96436141465682e-13 miRanda -0.326039418271956 3.89750223667119e-06 NA NA NA hsa-miR-421 GADD45G 0.941856334694081 6.12167297054077e-08 -1.8078339802055 7.96436141465682e-13 miRanda -0.556853667845386 1.3427336009444e-15 NA NA NA hsa-miR-429 GADD45G -1.40262535827285 6.93982219171912e-05 -1.8078339802055 7.96436141465682e-13 miRNATAP -0.116320782056629 0.00122761610181022 NA NA NA hsa-miR-502-5p GADD45G 0.892373335336396 1.7122694518919e-06 -1.8078339802055 7.96436141465682e-13 miRNATAP -0.210942956888822 0.00206657080418105 NA NA NA hsa-miR-30e-3p GNA12 -1.20845647373031 3.10263633528203e-25 0.601225554154701 1.98193833212861e-09 MirTarget -0.111795407402252 0.00562199675323771 NA NA NA hsa-miR-107 GNG12 0.241662461253461 0.0170788899505389 -0.749024820971969 9.12787292602269e-08 miRanda -0.352109955711477 2.43072591256035e-07 NA NA NA hsa-miR-338-3p GNG12 0.543135607704581 0.00461167747143826 -0.749024820971969 9.12787292602269e-08 miRanda -0.148937421383934 3.25125790279736e-05 NA NA NA hsa-miR-423-5p GNG12 0.698807775906485 1.02195196334612e-11 -0.749024820971969 9.12787292602269e-08 miRNAWalker2_validate -0.289354784524697 1.13499456269689e-05 NA NA NA hsa-miR-455-5p GNG12 -0.270546034117157 0.0581320703577731 -0.749024820971969 9.12787292602269e-08 miRanda -0.226520595073207 2.68617949312973e-06 NA NA NA hsa-let-7a-5p HRAS -0.328069937201898 0.000464344093744051 0.80680940319204 2.11618137601331e-10 miRNAWalker2_validate;miRTarBase -0.411742589318827 6.60009421951558e-10 20607356;23134218;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;;progression glioblastoma;lung squamous cell cancer;lung cancer;lung cancer;pancreatic cancer hsa-let-7b-5p HRAS -0.959013717270803 5.95127281258643e-11 0.80680940319204 2.11618137601331e-10 miRTarBase -0.270772577779286 5.9733154777202e-11 20607356;20881268;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;On the basis of these data we suggest that the downregulation of let-7b and let-7e targeting K-ras and the upregulation of miR-17* a CRC marker could be considered as candidate molecular markers of cetuximab resistance;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;drug resistance;;;progression glioblastoma;colorectal cancer;lung cancer;lung cancer;pancreatic cancer hsa-miR-143-3p HRAS -0.584123869220553 0.000907217687997436 0.80680940319204 2.11618137601331e-10 miRNAWalker2_validate;miRTarBase -0.141161766298964 7.30370553951274e-05 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-335-5p HSPA1A -1.61347836513558 1.62757083289711e-19 0.566420886676813 0.000534502700925593 miRNAWalker2_validate -0.164436469231978 0.00011729257927052 NA NA NA hsa-miR-22-3p HSPA1B -0.628561621952407 1.33755558015523e-09 0.500062250723722 0.0177938871093333 miRNAWalker2_validate -0.300778981891712 0.00218774237452039 NA NA NA hsa-miR-342-3p HSPA1L -0.319677314984262 0.0449813878317147 0.228560098845087 0.0389874209786542 miRanda -0.15020756505504 7.77731238583098e-06 NA NA NA hsa-miR-192-5p HSPA2 -0.50188499512787 0.00344713341196035 0.245419691266019 0.113504150863356 miRNAWalker2_validate -0.206197602451252 2.16593621163362e-06 NA NA NA hsa-miR-15b-5p HSPA8 0.230566941413564 0.0824765001857479 -0.145876100788158 0.199366356185968 miRNAWalker2_validate -0.182255355562181 1.12574536748578e-05 NA NA NA hsa-miR-16-5p HSPA8 -0.398577235179603 0.000101598495180191 -0.145876100788158 0.199366356185968 miRNAWalker2_validate -0.179158614870321 0.000886560644438095 NA NA NA hsa-miR-92a-3p HSPA8 0.212391012518195 0.134292268089997 -0.145876100788158 0.199366356185968 miRNAWalker2_validate -0.106535306704369 0.00644455001828979 NA NA NA hsa-miR-125a-5p IKBKG -0.91219969372382 1.38256246489548e-07 0.660366120199928 1.71867865546723e-06 miRanda -0.219029418282295 9.51829321882113e-09 NA NA NA hsa-miR-143-3p IKBKG -0.584123869220553 0.000907217687997436 0.660366120199928 1.71867865546723e-06 mirMAP -0.169551761758995 9.09905571393035e-06 NA NA NA hsa-miR-200a-3p IKBKG -1.49949292595657 3.18410995256133e-05 0.660366120199928 1.71867865546723e-06 mirMAP -0.100439586597671 5.62621816828972e-08 NA NA NA hsa-miR-24-3p IKBKG -0.257825594021966 0.00689742600215061 0.660366120199928 1.71867865546723e-06 mirMAP -0.287544034512102 5.8686253015948e-05 NA NA NA hsa-miR-3065-3p IKBKG -1.04244468016704 4.60743424372577e-05 0.660366120199928 1.71867865546723e-06 mirMAP -0.115721435331344 9.61381024877344e-06 NA NA NA hsa-miR-320a IKBKG 0.325285936317332 0.0221415065838824 0.660366120199928 1.71867865546723e-06 mirMAP -0.182311319218153 0.000133876392194021 NA NA NA hsa-miR-320b IKBKG 0.0919652022571331 0.607981643616945 0.660366120199928 1.71867865546723e-06 mirMAP -0.132285547849802 0.000522961413620221 NA NA NA hsa-miR-335-5p IKBKG -1.61347836513558 1.62757083289711e-19 0.660366120199928 1.71867865546723e-06 mirMAP -0.273399124951207 9.32430291537739e-15 NA NA NA hsa-miR-338-5p IKBKG -0.221898432884726 0.252390988727086 0.660366120199928 1.71867865546723e-06 mirMAP -0.206675822417303 2.68501101428877e-09 NA NA NA hsa-miR-376c-3p IKBKG -1.78544013329054 1.82972185127691e-10 0.660366120199928 1.71867865546723e-06 mirMAP -0.14083607992738 1.85430800686914e-09 NA NA NA hsa-miR-542-3p IKBKG -1.31351015149842 3.64642423288576e-22 0.660366120199928 1.71867865546723e-06 mirMAP -0.292142688932618 4.40119371820177e-10 NA NA NA hsa-miR-17-3p IL1R1 0.410352776142368 0.00422200500748636 -1.01045381057689 4.50684679449702e-13 mirMAP -0.39073755100076 1.02125622521434e-16 NA NA NA hsa-miR-181a-5p IL1R1 0.250113435902954 0.0551933249319293 -1.01045381057689 4.50684679449702e-13 mirMAP -0.2322434157224 1.42776581461954e-05 NA NA NA hsa-miR-181b-5p IL1R1 0.488256489401108 0.00105321129419701 -1.01045381057689 4.50684679449702e-13 mirMAP -0.246016811028355 1.07107101412662e-07 NA NA NA hsa-miR-542-3p JMJD7-PLA2G4B -1.31351015149842 3.64642423288576e-22 0.293448490781786 0.00123679425607597 miRNATAP -0.122126258868508 7.88924194144572e-05 NA NA NA hsa-miR-501-5p JUN 1.15231083477882 2.98906150004088e-10 -1.59869078760734 2.2999762521731e-23 MirTarget;PITA;miRNATAP -0.201525326742419 4.62918338980132e-06 NA NA NA hsa-miR-92a-3p JUN 0.212391012518195 0.134292268089997 -1.59869078760734 2.2999762521731e-23 miRNATAP -0.217656471355875 0.000190729748454868 NA NA NA hsa-miR-93-5p JUN 1.39518349670953 2.84167728726712e-25 -1.59869078760734 2.2999762521731e-23 miRNAWalker2_validate -0.346015058492204 1.41571654493278e-09 NA NA NA hsa-miR-589-3p JUND 1.16846704028095 5.88525574424201e-11 -0.943706664683874 2.21523898174391e-11 MirTarget -0.133579426770836 0.000680765333395728 NA NA NA hsa-miR-140-3p KRAS 0.546012239205329 4.84578261098777e-11 -0.338081744192936 0.00043842779003105 MirTarget -0.247198429138234 9.22756583574077e-06 NA NA NA hsa-miR-16-1-3p KRAS 0.392360028038559 0.00112481918108198 -0.338081744192936 0.00043842779003105 mirMAP -0.114704330599848 0.00330327136149234 NA NA NA hsa-miR-193a-3p KRAS -0.117675551589896 0.309391958208578 -0.338081744192936 0.00043842779003105 MirTarget;miRanda;miRNATAP -0.128182356310374 0.00170700856743147 NA NA NA hsa-miR-193b-3p KRAS -0.166697207281748 0.272022543069482 -0.338081744192936 0.00043842779003105 miRNAWalker2_validate;MirTarget;miRNATAP -0.120510531869791 9.78248377856047e-05 25905463 Deregulation of the MiR 193b KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer; Mechanistically KRAS was verified as a direct effector of miR-193b through which the AKT and ERK pathways were modulated and cell growth of PDAC cells was suppressed; Taken together our findings indicate that miR-193b-mediated deregulation of the KRAS axis is involved in pancreatic carcinogenesis and suggest that miR-193b could be a potentially effective target for PDAC therapy tumorigenesis pancreatic cancer hsa-miR-30d-3p KRAS -0.120562286038759 0.329549534782125 -0.338081744192936 0.00043842779003105 MirTarget;miRNATAP -0.132565215112955 0.000512493362671086 NA NA NA hsa-miR-532-5p KRAS 1.02729546510601 9.93318913966636e-16 -0.338081744192936 0.00043842779003105 MirTarget;PITA;miRNATAP -0.137739612561571 0.000100604507963156 NA NA NA hsa-miR-140-3p MAP2K1 0.546012239205329 4.84578261098777e-11 -1.22814648702538 4.27448032410174e-41 PITA -0.381987666476187 3.26697824928144e-11 NA NA NA hsa-miR-34a-5p MAP2K1 1.03694231790865 5.74864019540594e-14 -1.22814648702538 4.27448032410174e-41 miRNAWalker2_validate;miRTarBase -0.229470281840033 1.32655977381036e-11 NA NA NA hsa-miR-361-5p MAP2K1 0.233202959858696 0.00961572812255327 -1.22814648702538 4.27448032410174e-41 miRanda -0.180575442044722 0.00107072926955335 NA NA NA hsa-miR-501-5p MAP2K1 1.15231083477882 2.98906150004088e-10 -1.22814648702538 4.27448032410174e-41 PITA -0.144135390798289 3.07397683406163e-08 NA NA NA hsa-let-7b-5p MAP2K2 -0.959013717270803 5.95127281258643e-11 0.626002935787801 2.22116323165311e-10 miRNAWalker2_validate -0.179048006528372 3.03569472992354e-08 NA NA NA hsa-miR-15a-5p MAP2K3 0.349521211668244 0.000770735998804736 -1.21754800169498 4.92442767488047e-26 MirTarget;miRNATAP -0.176252893813344 0.00227092078142843 NA NA NA hsa-miR-15b-5p MAP2K3 0.230566941413564 0.0824765001857479 -1.21754800169498 4.92442767488047e-26 MirTarget;miRNATAP -0.200212947409933 8.28849357211579e-06 NA NA NA hsa-miR-20a-5p MAP2K3 0.854326758727003 5.04256669663285e-07 -1.21754800169498 4.92442767488047e-26 miRTarBase -0.146114431767222 2.34481412513752e-05 NA NA NA hsa-miR-21-5p MAP2K3 1.51084295924322 1.54551622173259e-34 -1.21754800169498 4.92442767488047e-26 MirTarget -0.296630051548559 1.21863335298365e-11 24112539 The 3'-untranslated region 3'-UTR of MAP2K3 combined with miR-21 was experimentally verified by a miRNA luciferase reporter approach; More importantly the repression of MAP2K3 was inversely correlated with the expression of miR-21 in HCC; Further study demonstrated that the MAP2K3 was a novel direct target of miR-21 which was experimentally validated by a miRNA luciferase reporter approach; In HepG2 cells inhibition of miR-21 expression with an adenoviral miR-21 sponge vector profoundly suppressed cell proliferation by up-regulating MAP2K3 expression at both mRNA and protein levels; These results provide a clinical evidence that MAP2K3 may be a tumor repressor gene and it is a direct target of miR-21 in HCC indicating an underlying mechanism by which miR-21 is able to directly target MAP2K3 and inhibit its expression during the carcinogenesis of HCC at both transcriptional and post-translational levels tumorigenesis liver cancer hsa-miR-34a-5p MAP2K3 1.03694231790865 5.74864019540594e-14 -1.21754800169498 4.92442767488047e-26 miRNATAP -0.115763181314296 0.00601948155472633 NA NA NA hsa-miR-421 MAP2K3 0.941856334694081 6.12167297054077e-08 -1.21754800169498 4.92442767488047e-26 miRanda -0.160136254759765 2.05210766717661e-06 NA NA NA hsa-miR-15b-5p MAP2K4 0.230566941413564 0.0824765001857479 -0.879687142912805 1.35049317084043e-24 miRNAWalker2_validate -0.16773703980265 4.18020308379227e-07 NA NA NA hsa-miR-25-3p MAP2K4 0.633062563556379 3.68686354834328e-10 -0.879687142912805 1.35049317084043e-24 miRNATAP -0.192904256731321 7.28569782472706e-06 NA NA NA hsa-miR-590-3p MAP2K5 -0.473167498047808 1.76652934637227e-05 0.0409677852182209 0.616799398719229 miRanda -0.102764651334407 0.00421456304617667 NA NA NA hsa-miR-125b-5p MAP3K1 -1.35767721102906 1.16564617395164e-18 0.0159561891588775 0.877325572084852 miRNATAP -0.11431829118445 0.00024134367971076 NA NA NA hsa-miR-139-5p MAP3K1 -2.11299531796557 8.16407076415038e-28 0.0159561891588775 0.877325572084852 miRanda -0.113087719069936 2.56009314429985e-06 NA NA NA hsa-miR-192-5p MAP3K1 -0.50188499512787 0.00344713341196035 0.0159561891588775 0.877325572084852 miRNAWalker2_validate -0.12056340177866 3.22770061138135e-05 NA NA NA hsa-miR-125a-5p MAP3K11 -0.91219969372382 1.38256246489548e-07 0.231323810162627 0.00378005734249343 PITA;miRanda;miRNATAP -0.14186224802274 6.04374109025996e-11 NA NA NA hsa-miR-542-3p MAP3K11 -1.31351015149842 3.64642423288576e-22 0.231323810162627 0.00378005734249343 miRanda;miRNATAP -0.163407479881703 1.05684028240817e-09 NA NA NA hsa-miR-26b-5p MAP3K12 -1.10804856399744 4.14176110314282e-22 0.334893786989642 0.0179755392811318 miRNAWalker2_validate -0.206019198015309 0.000323909475971008 NA NA NA hsa-miR-27b-3p MAP3K12 -0.823491817819754 9.20935302746823e-14 0.334893786989642 0.0179755392811318 miRNATAP -0.211348277410436 0.000513662281963951 NA NA NA hsa-miR-30e-5p MAP3K12 -0.627815042856657 3.02205690184908e-10 0.334893786989642 0.0179755392811318 MirTarget -0.26126055014286 0.000126359732055004 NA NA NA hsa-miR-106b-5p MAP3K13 0.648901865047099 8.24870862047885e-09 -0.448996281023736 0.0575259551730977 miRNATAP -0.277830161122012 0.00610271622987929 NA NA NA hsa-miR-1301-3p MAP3K13 1.12156714169769 4.22404125385203e-10 -0.448996281023736 0.0575259551730977 MirTarget -0.348076650601704 1.98429558664506e-08 NA NA NA hsa-miR-149-5p MAP3K13 -0.317176971910036 0.187207559733877 -0.448996281023736 0.0575259551730977 MirTarget -0.161242474901134 0.000798268766198606 NA NA NA hsa-miR-17-5p MAP3K13 0.698861147045461 2.43854106455398e-05 -0.448996281023736 0.0575259551730977 miRNATAP -0.291614181029648 2.1849998265129e-05 NA NA NA hsa-miR-181a-5p MAP3K13 0.250113435902954 0.0551933249319293 -0.448996281023736 0.0575259551730977 mirMAP -0.286787909446984 0.00120999917165148 NA NA NA hsa-miR-181b-5p MAP3K13 0.488256489401108 0.00105321129419701 -0.448996281023736 0.0575259551730977 mirMAP -0.272541117721565 0.00039983088740065 NA NA NA hsa-miR-181c-5p MAP3K13 -0.00639394152050299 0.969127212255928 -0.448996281023736 0.0575259551730977 mirMAP -0.225370046601135 0.00126536801309552 NA NA NA hsa-miR-188-5p MAP3K13 1.11646899351496 9.56686958408598e-11 -0.448996281023736 0.0575259551730977 mirMAP -0.276683819217825 2.17896022750626e-05 NA NA NA hsa-miR-20a-5p MAP3K13 0.854326758727003 5.04256669663285e-07 -0.448996281023736 0.0575259551730977 miRNATAP -0.184087143328605 0.00601036434848416 NA NA NA hsa-miR-20b-5p MAP3K13 0.457668023910379 0.0285865211936156 -0.448996281023736 0.0575259551730977 miRNATAP -0.186126371506842 0.000705483110765845 NA NA NA hsa-miR-32-3p MAP3K13 0.219109440121582 0.207217051619543 -0.448996281023736 0.0575259551730977 mirMAP;miRNATAP -0.211109246513342 0.00209167131406369 NA NA NA hsa-miR-339-5p MAP3K13 0.280589919878422 0.0355660282647215 -0.448996281023736 0.0575259551730977 miRanda -0.285120181666899 0.000979481240280951 NA NA NA hsa-miR-421 MAP3K13 0.941856334694081 6.12167297054077e-08 -0.448996281023736 0.0575259551730977 MirTarget -0.309749052942872 1.88728287437579e-06 NA NA NA hsa-miR-432-5p MAP3K13 -0.536178819038888 0.0748623258271085 -0.448996281023736 0.0575259551730977 MirTarget -0.100713357730632 0.00871923501642769 NA NA NA hsa-miR-500a-5p MAP3K13 0.797906382969156 9.15958171084226e-08 -0.448996281023736 0.0575259551730977 mirMAP -0.332561669663289 1.12020767641457e-05 NA NA NA hsa-miR-502-5p MAP3K13 0.892373335336396 1.7122694518919e-06 -0.448996281023736 0.0575259551730977 miRNATAP -0.211751674597073 0.000671733676519964 NA NA NA hsa-miR-539-5p MAP3K13 -0.589854500338464 0.0510819604083499 -0.448996281023736 0.0575259551730977 mirMAP -0.10037066580929 0.0086178553574051 NA NA NA hsa-miR-582-5p MAP3K13 -0.680189083316822 0.00103755166534107 -0.448996281023736 0.0575259551730977 miRNATAP -0.212744690030451 0.000120065852781741 NA NA NA hsa-miR-877-5p MAP3K13 1.35669625926821 1.43008125755656e-11 -0.448996281023736 0.0575259551730977 miRNATAP -0.341280544872351 3.16275120225613e-09 NA NA NA hsa-miR-93-5p MAP3K13 1.39518349670953 2.84167728726712e-25 -0.448996281023736 0.0575259551730977 miRNAWalker2_validate;miRNATAP -0.337974111453947 2.72155103145301e-05 NA NA NA hsa-miR-17-3p MAP3K14 0.410352776142368 0.00422200500748636 -0.256732855579524 0.0805960527428211 MirTarget -0.134473480210187 0.00705656422421302 NA NA NA hsa-miR-17-5p MAP3K14 0.698861147045461 2.43854106455398e-05 -0.256732855579524 0.0805960527428211 MirTarget -0.200236479730088 2.50369988878285e-06 NA NA NA hsa-miR-20a-5p MAP3K14 0.854326758727003 5.04256669663285e-07 -0.256732855579524 0.0805960527428211 MirTarget -0.157807215094265 0.000138930673437178 NA NA NA hsa-miR-874-3p MAP3K14 -1.07043026298634 2.09564226589678e-07 -0.256732855579524 0.0805960527428211 MirTarget -0.122908909256529 0.000312223440563301 NA NA NA hsa-miR-106b-5p MAP3K2 0.648901865047099 8.24870862047885e-09 -0.770538748173389 6.13734867546361e-08 MirTarget;miRNATAP -0.289375320332452 2.36311060029421e-06 NA NA NA hsa-miR-148b-5p MAP3K2 0.295777213389605 0.0255749859535438 -0.770538748173389 6.13734867546361e-08 mirMAP -0.159627512880959 0.00276272212061255 NA NA NA hsa-miR-17-5p MAP3K2 0.698861147045461 2.43854106455398e-05 -0.770538748173389 6.13734867546361e-08 MirTarget;TargetScan;miRNATAP -0.299782183765645 2.90685353457532e-13 NA NA NA hsa-miR-181a-5p MAP3K2 0.250113435902954 0.0551933249319293 -0.770538748173389 6.13734867546361e-08 mirMAP -0.222650024281137 3.59806321392436e-05 NA NA NA hsa-miR-181b-5p MAP3K2 0.488256489401108 0.00105321129419701 -0.770538748173389 6.13734867546361e-08 mirMAP -0.179966533909382 0.000126100967797753 NA NA NA hsa-miR-19a-3p MAP3K2 1.01712596153672 2.57753201450625e-07 -0.770538748173389 6.13734867546361e-08 MirTarget;mirMAP;miRNATAP -0.182607418748908 1.47535480870755e-07 NA NA NA hsa-miR-19b-3p MAP3K2 0.601279551368824 0.00016685097085251 -0.770538748173389 6.13734867546361e-08 MirTarget;mirMAP;miRNATAP -0.230067258644107 1.09698861161858e-07 NA NA NA hsa-miR-20a-5p MAP3K2 0.854326758727003 5.04256669663285e-07 -0.770538748173389 6.13734867546361e-08 MirTarget;miRNATAP -0.25799642930204 1.23793599245169e-10 NA NA NA hsa-miR-21-5p MAP3K2 1.51084295924322 1.54551622173259e-34 -0.770538748173389 6.13734867546361e-08 miRNAWalker2_validate;mirMAP -0.282876404225472 5.34149880909856e-08 NA NA NA hsa-miR-221-3p MAP3K2 1.12244756358612 3.48370308238012e-13 -0.770538748173389 6.13734867546361e-08 MirTarget -0.239445403358139 4.60022991721426e-08 NA NA NA hsa-miR-222-3p MAP3K2 1.08574156066353 1.76407192348131e-11 -0.770538748173389 6.13734867546361e-08 MirTarget -0.190649654673579 6.47923726771857e-06 NA NA NA hsa-miR-30b-5p MAP3K2 -0.54056186708617 2.44688760798341e-05 -0.770538748173389 6.13734867546361e-08 mirMAP;miRNATAP -0.150237123045351 0.00605408298920415 NA NA NA hsa-miR-30d-3p MAP3K2 -0.120562286038759 0.329549534782125 -0.770538748173389 6.13734867546361e-08 MirTarget -0.168754839882828 0.00321787728842491 NA NA NA hsa-miR-30d-5p MAP3K2 0.718283816348023 2.47422074061352e-08 -0.770538748173389 6.13734867546361e-08 mirMAP;miRNATAP -0.21025226194585 9.13358642300474e-05 NA NA NA hsa-miR-338-3p MAP3K2 0.543135607704581 0.00461167747143826 -0.770538748173389 6.13734867546361e-08 miRNATAP -0.13578465825699 0.000197513875066724 NA NA NA hsa-miR-455-5p MAP3K2 -0.270546034117157 0.0581320703577731 -0.770538748173389 6.13734867546361e-08 miRNATAP -0.242113129076012 7.56196724527458e-07 NA NA NA hsa-miR-590-5p MAP3K2 -0.103355559980404 0.310027295317092 -0.770538748173389 6.13734867546361e-08 mirMAP -0.205674334238505 0.00324291227771718 NA NA NA hsa-miR-766-3p MAP3K2 0.199979324759329 0.257230732626744 -0.770538748173389 6.13734867546361e-08 MirTarget -0.109596788516607 0.00609530794817379 NA NA NA hsa-miR-93-5p MAP3K2 1.39518349670953 2.84167728726712e-25 -0.770538748173389 6.13734867546361e-08 MirTarget;miRNATAP -0.326728572972345 1.43078985235362e-11 NA NA NA hsa-miR-22-3p MAP3K3 -0.628561621952407 1.33755558015523e-09 0.0104889868708602 0.888426899769504 MirTarget;miRNATAP -0.101580693430174 0.00322006100695006 NA NA NA hsa-miR-106b-5p MAP3K5 0.648901865047099 8.24870862047885e-09 -1.33601122467136 1.03028348684945e-07 miRNATAP -0.729531730436429 8.02399046498718e-12 NA NA NA hsa-miR-146b-5p MAP3K5 0.419719546795449 0.0457375823220155 -1.33601122467136 1.03028348684945e-07 miRanda -0.319441648919432 4.29798576572251e-08 NA NA NA hsa-miR-17-5p MAP3K5 0.698861147045461 2.43854106455398e-05 -1.33601122467136 1.03028348684945e-07 TargetScan;miRNATAP -0.410209125139946 2.35278527136033e-08 NA NA NA hsa-miR-20a-5p MAP3K5 0.854326758727003 5.04256669663285e-07 -1.33601122467136 1.03028348684945e-07 miRNATAP -0.349691468275886 1.01213992658686e-06 NA NA NA hsa-miR-30d-5p MAP3K5 0.718283816348023 2.47422074061352e-08 -1.33601122467136 1.03028348684945e-07 miRNATAP -0.583490572697977 4.45519302742705e-10 NA NA NA hsa-miR-429 MAP3K5 -1.40262535827285 6.93982219171912e-05 -1.33601122467136 1.03028348684945e-07 PITA;miRanda;miRNATAP -0.116493304561914 0.000967212666258057 NA NA NA hsa-miR-93-5p MAP3K5 1.39518349670953 2.84167728726712e-25 -1.33601122467136 1.03028348684945e-07 miRNATAP -0.72276414519857 7.55492204858739e-18 NA NA NA hsa-miR-92a-3p MAP3K6 0.212391012518195 0.134292268089997 0.152700559350431 0.275120216255039 miRNAWalker2_validate -0.20269474721996 2.29373354907825e-05 NA NA NA hsa-miR-30d-3p MAP3K7 -0.120562286038759 0.329549534782125 0.0227052645956216 0.800739743576642 MirTarget -0.152801707733114 1.47792797573938e-05 NA NA NA hsa-miR-106a-5p MAP3K8 -0.464229535269236 0.009724944358047 -0.159965748968671 0.44777579319131 MirTarget;miRNATAP -0.153714084956856 0.00705904503964807 NA NA NA hsa-miR-128-3p MAP3K8 0.289735108018712 0.0114419474207889 -0.159965748968671 0.44777579319131 MirTarget -0.352349307652992 8.3395753926417e-05 NA NA NA hsa-miR-375 MAP3K8 -1.93190458972328 4.28108492522e-06 -0.159965748968671 0.44777579319131 miRNAWalker2_validate -0.198692409488075 9.63596719768765e-18 NA NA NA hsa-miR-30c-1-3p MAP4K1 -1.39373825444537 6.39912952911454e-17 -0.285954091863821 0.215342736728265 MirTarget -0.20549712694044 0.00177182680396727 NA NA NA hsa-miR-324-5p MAP4K3 0.372933276649782 0.00592280066108904 0.165531484576933 0.115910220334012 MirTarget;PITA;miRanda -0.104640994513741 0.00565292971216681 NA NA NA hsa-miR-342-3p MAP4K3 -0.319677314984262 0.0449813878317147 0.165531484576933 0.115910220334012 miRanda -0.104827129144589 0.00108415473248677 NA NA NA hsa-miR-29a-3p MAP4K4 -0.856762511178136 4.65330336378459e-12 0.521517663752677 1.06487649030441e-08 miRNATAP -0.261754180395283 3.78445315084039e-14 NA NA NA hsa-miR-29b-3p MAP4K4 -0.348885528720517 0.0121441341291285 0.521517663752677 1.06487649030441e-08 miRNATAP -0.171032224196049 9.52524164382961e-08 NA NA NA hsa-miR-29c-3p MAP4K4 -1.4367517608807 1.61767774905781e-21 0.521517663752677 1.06487649030441e-08 miRNATAP -0.199275181647567 6.56755058404354e-13 NA NA NA hsa-miR-511-5p MAP4K4 -1.75067415533112 3.37801163573342e-23 0.521517663752677 1.06487649030441e-08 MirTarget -0.12139577876297 3.85764727261625e-07 NA NA NA hsa-miR-130b-3p MAPK10 0.687190305027546 0.000109068658562255 -1.09210524801043 3.20431274629696e-05 miRNATAP -0.246373643413876 0.000632339067040355 NA NA NA hsa-miR-146b-5p MAPK10 0.419719546795449 0.0457375823220155 -1.09210524801043 3.20431274629696e-05 miRanda -0.252372073662625 3.58793936262133e-05 NA NA NA hsa-miR-19a-3p MAPK10 1.01712596153672 2.57753201450625e-07 -1.09210524801043 3.20431274629696e-05 miRNATAP -0.168630672973342 0.00898420702556428 NA NA NA hsa-miR-221-3p MAPK10 1.12244756358612 3.48370308238012e-13 -1.09210524801043 3.20431274629696e-05 miRNATAP -0.345546531666561 1.95748420882985e-05 NA NA NA hsa-miR-222-3p MAPK10 1.08574156066353 1.76407192348131e-11 -1.09210524801043 3.20431274629696e-05 miRNATAP -0.215253828844877 0.00588066987412212 NA NA NA hsa-miR-455-5p MAPK10 -0.270546034117157 0.0581320703577731 -1.09210524801043 3.20431274629696e-05 miRanda -0.235174401855498 0.00956735979323835 NA NA NA hsa-miR-590-5p MAPK10 -0.103355559980404 0.310027295317092 -1.09210524801043 3.20431274629696e-05 PITA;miRanda;miRNATAP -0.3693102549963 0.00397298728893767 NA NA NA hsa-miR-122-5p MAPK11 -1.23907441373955 4.42181244888642e-06 1.21323727189264 5.55548436625349e-12 miRNAWalker2_validate;miRTarBase -0.10214514237859 0.00150685569234902 NA NA NA hsa-miR-27a-3p MAPK14 -0.370807380415112 0.00875721956202713 -0.144548626010916 0.0495454672602603 MirTarget;miRNATAP -0.141879704151399 1.17885364887775e-08 NA NA NA hsa-miR-27b-3p MAPK7 -0.823491817819754 9.20935302746823e-14 0.305136164161477 0.000440978428375878 miRNATAP -0.123415319315889 0.000963752517439649 NA NA NA hsa-miR-30b-5p MAPK8 -0.54056186708617 2.44688760798341e-05 -0.855423391564126 4.38860774117184e-05 mirMAP -0.211224878227047 0.0083058660521866 NA NA NA hsa-miR-30d-5p MAPK8 0.718283816348023 2.47422074061352e-08 -0.855423391564126 4.38860774117184e-05 mirMAP -0.215078369558139 0.00642208423108097 NA NA NA hsa-miR-125b-2-3p MAPK8IP2 -1.6609436107315 5.71534047969855e-18 2.63392070012632 1.02369935409566e-14 mirMAP -0.287048277446868 0.000793923546228865 NA NA NA hsa-miR-125b-5p MAPK8IP2 -1.35767721102906 1.16564617395164e-18 2.63392070012632 1.02369935409566e-14 mirMAP -0.554430606065706 1.55995854344091e-07 NA NA NA hsa-miR-130a-3p MAPK8IP2 -1.53229181736223 2.91460363624872e-19 2.63392070012632 1.02369935409566e-14 mirMAP -0.386389115615365 5.38187100149435e-05 NA NA NA hsa-miR-22-5p MAPK8IP2 -0.630365901263172 3.32415348030414e-05 2.63392070012632 1.02369935409566e-14 mirMAP -0.421639645298005 0.00016523336957115 NA NA NA hsa-miR-424-5p MAPK8IP2 -2.62653257498508 2.38997974737991e-50 2.63392070012632 1.02369935409566e-14 mirMAP -0.37967583784219 8.9905499499638e-06 NA NA NA hsa-miR-542-3p MAPK8IP2 -1.31351015149842 3.64642423288576e-22 2.63392070012632 1.02369935409566e-14 mirMAP -0.335481814604898 0.0053404628799537 NA NA NA hsa-miR-194-3p MAPK8IP3 -0.772747277805343 2.9537465170191e-05 1.01234491290533 3.03085078878221e-14 mirMAP -0.138360806255982 0.000109915430375278 NA NA NA hsa-miR-22-3p MAPK8IP3 -0.628561621952407 1.33755558015523e-09 1.01234491290533 3.03085078878221e-14 MirTarget -0.314115386963014 6.92995851833492e-07 NA NA NA hsa-miR-27b-3p MAPK8IP3 -0.823491817819754 9.20935302746823e-14 1.01234491290533 3.03085078878221e-14 miRNATAP -0.159381047264504 0.00713313993309301 NA NA NA hsa-miR-326 MAPK8IP3 -1.881935132554 1.68087316863775e-21 1.01234491290533 3.03085078878221e-14 mirMAP -0.148426088404929 4.24375088398738e-06 NA NA NA hsa-miR-140-5p MAPK9 -0.220106443070144 0.0140713197101242 0.23378807508407 0.00112433159060846 miRanda -0.130430637695707 0.000917008693159836 NA NA NA hsa-miR-590-3p MAPK9 -0.473167498047808 1.76652934637227e-05 0.23378807508407 0.00112433159060846 miRanda;mirMAP -0.101280114384897 0.00134322482300103 NA NA NA hsa-miR-27b-5p MAPKAPK2 -0.084323722931086 0.480868599074588 0.541891587314344 7.22097315323501e-09 mirMAP -0.185470034671812 1.62440858476697e-06 NA NA NA hsa-miR-320a MAPKAPK2 0.325285936317332 0.0221415065838824 0.541891587314344 7.22097315323501e-09 miRanda -0.107439527461255 0.000979262051929608 NA NA NA hsa-miR-486-5p MAPKAPK2 -1.77766890600022 2.9071717929922e-14 0.541891587314344 7.22097315323501e-09 miRanda -0.101354332717813 8.58450817232234e-08 NA NA NA hsa-miR-10a-5p MAPT -1.47723516092033 7.27299669108673e-16 2.58490052544186 2.18799071553378e-25 mirMAP -0.260338652424572 0.000115276409388554 NA NA NA hsa-miR-125b-2-3p MAPT -1.6609436107315 5.71534047969855e-18 2.58490052544186 2.18799071553378e-25 mirMAP -0.280399977215277 1.12254059910117e-05 NA NA NA hsa-miR-146b-3p MAPT -1.20799545896423 2.19859530890688e-09 2.58490052544186 2.18799071553378e-25 miRNATAP -0.266610539690504 1.77248622289996e-05 NA NA NA hsa-miR-150-5p MAPT -1.14624309254329 1.51365525978726e-06 2.58490052544186 2.18799071553378e-25 mirMAP -0.179592776303304 0.000735884753606574 NA NA NA hsa-miR-214-5p MAPT -1.91497809567701 3.92955595018147e-12 2.58490052544186 2.18799071553378e-25 MirTarget -0.134299912062498 0.00349347879837339 NA NA NA hsa-miR-2355-3p MAPT -0.471227472721651 0.00718598113738346 2.58490052544186 2.18799071553378e-25 miRNATAP -0.194481561438488 0.0082798793659556 NA NA NA hsa-miR-27b-3p MAPT -0.823491817819754 9.20935302746823e-14 2.58490052544186 2.18799071553378e-25 miRNATAP -0.53917741089395 1.73408872285656e-06 NA NA NA hsa-miR-27b-5p MAPT -0.084323722931086 0.480868599074588 2.58490052544186 2.18799071553378e-25 mirMAP -0.452714677165565 2.67693163621802e-05 NA NA NA hsa-miR-28-5p MAPT -0.430964830599964 2.67367257252925e-06 2.58490052544186 2.18799071553378e-25 mirMAP -0.417261428739178 0.00294562301830459 NA NA NA hsa-miR-30a-3p MAPT -1.52720594401486 1.3830066075708e-17 2.58490052544186 2.18799071553378e-25 mirMAP -0.269382476532946 9.01957702443651e-05 NA NA NA hsa-miR-30e-3p MAPT -1.20845647373031 3.10263633528203e-25 2.58490052544186 2.18799071553378e-25 mirMAP -0.713593369310487 2.7627400563123e-12 NA NA NA hsa-miR-335-5p MAPT -1.61347836513558 1.62757083289711e-19 2.58490052544186 2.18799071553378e-25 mirMAP -0.50366914305049 5.23019142988972e-14 NA NA NA hsa-miR-450b-5p MAPT -1.34333360369432 2.68386079790462e-17 2.58490052544186 2.18799071553378e-25 mirMAP -0.406617361335371 1.3238196698606e-07 NA NA NA hsa-miR-495-3p MAPT -0.751193061269953 0.00388779118736635 2.58490052544186 2.18799071553378e-25 mirMAP -0.133592552970801 0.00683751192737571 NA NA NA hsa-miR-505-5p MAPT -0.768282569967001 1.14662846595407e-05 2.58490052544186 2.18799071553378e-25 MirTarget -0.381437731747387 1.17393222103414e-07 NA NA NA hsa-miR-582-3p MAPT -0.653831905315466 0.00248607706603299 2.58490052544186 2.18799071553378e-25 PITA;miRNATAP -0.172561681028785 0.00360520543363576 NA NA NA hsa-miR-7-1-3p MAPT -0.569105143287799 1.85297665041424e-05 2.58490052544186 2.18799071553378e-25 mirMAP -0.426311650503072 8.38868887051033e-06 NA NA NA hsa-miR-874-3p MAPT -1.07043026298634 2.09564226589678e-07 2.58490052544186 2.18799071553378e-25 MirTarget -0.302512853637096 6.81349582276719e-07 NA NA NA hsa-miR-28-5p MAX -0.430964830599964 2.67367257252925e-06 -0.117623884058569 0.0793768137364185 miRanda -0.103740194722348 0.00335337314006485 NA NA NA hsa-miR-107 MEF2C 0.241662461253461 0.0170788899505389 0.0778716667649269 0.518249252095398 miRanda -0.23747392956632 4.19133584520437e-05 NA NA NA hsa-miR-186-5p MEF2C -0.060103391373687 0.535288717081205 0.0778716667649269 0.518249252095398 miRNATAP -0.197963679647519 0.00119239666393406 NA NA NA hsa-miR-194-5p MEF2C -0.292530160992458 0.0996141384876663 0.0778716667649269 0.518249252095398 miRNATAP -0.200113971660217 6.62610057126619e-10 NA NA NA hsa-miR-19a-3p MEF2C 1.01712596153672 2.57753201450625e-07 0.0778716667649269 0.518249252095398 miRNATAP -0.107828720169222 0.000216108944603578 NA NA NA hsa-miR-19b-3p MEF2C 0.601279551368824 0.00016685097085251 0.0778716667649269 0.518249252095398 miRNATAP -0.125599767113762 0.000559225556173317 NA NA NA hsa-miR-32-3p MEF2C 0.219109440121582 0.207217051619543 0.0778716667649269 0.518249252095398 mirMAP -0.133642706647764 0.000119546018783709 NA NA NA hsa-miR-324-3p MEF2C 0.260348469146494 0.0506141704203545 0.0778716667649269 0.518249252095398 miRNATAP -0.11486741535266 0.00929252255277281 NA NA NA hsa-miR-33a-3p MEF2C -0.683025859637737 1.01106097756419e-05 0.0778716667649269 0.518249252095398 MirTarget;mirMAP;miRNATAP -0.185557801205476 6.24087181964508e-07 NA NA NA hsa-miR-425-5p MEF2C 0.585974239943864 2.23063410931402e-05 0.0778716667649269 0.518249252095398 MirTarget;miRNATAP -0.178012666225352 2.14933133165579e-05 NA NA NA hsa-miR-550a-3p MEF2C 0.0421988124005088 0.798971000685886 0.0778716667649269 0.518249252095398 MirTarget -0.159628888717956 8.52394957683238e-06 NA NA NA hsa-miR-590-5p MEF2C -0.103355559980404 0.310027295317092 0.0778716667649269 0.518249252095398 MirTarget;PITA;miRanda;miRNATAP -0.30282034874973 1.37054617833873e-07 NA NA NA hsa-miR-744-3p MEF2C -0.866026958622846 2.43034431433797e-08 0.0778716667649269 0.518249252095398 MirTarget;miRNATAP -0.127786367383584 0.000569164237022071 NA NA NA hsa-miR-92a-3p MEF2C 0.212391012518195 0.134292268089997 0.0778716667649269 0.518249252095398 miRNAWalker2_validate -0.13139545488099 0.00149899673902389 NA NA NA hsa-miR-21-5p MKNK2 1.51084295924322 1.54551622173259e-34 -0.0576836459714736 0.518912431453789 miRNAWalker2_validate -0.119547802728919 0.000218174804414907 NA NA NA hsa-miR-130b-5p MRAS 0.170599813152408 0.337611586432771 0.754170829241627 1.65059029700012e-05 mirMAP -0.138995975237236 0.00414551447496583 NA NA NA hsa-miR-15b-5p MRAS 0.230566941413564 0.0824765001857479 0.754170829241627 1.65059029700012e-05 miRNATAP -0.202201006776971 0.00188220563287176 NA NA NA hsa-miR-16-5p MRAS -0.398577235179603 0.000101598495180191 0.754170829241627 1.65059029700012e-05 miRNATAP -0.329966535450367 8.18571483517898e-05 NA NA NA hsa-miR-26b-5p MRAS -1.10804856399744 4.14176110314282e-22 0.754170829241627 1.65059029700012e-05 miRNATAP -0.277911131089481 9.88725753965834e-05 NA NA NA hsa-miR-30e-3p MRAS -1.20845647373031 3.10263633528203e-25 0.754170829241627 1.65059029700012e-05 mirMAP -0.201833414955771 0.00390915382879959 NA NA NA hsa-miR-486-5p MRAS -1.77766890600022 2.9071717929922e-14 0.754170829241627 1.65059029700012e-05 miRanda -0.104774719717466 0.00324805650492037 NA NA NA hsa-miR-7-1-3p MRAS -0.569105143287799 1.85297665041424e-05 0.754170829241627 1.65059029700012e-05 mirMAP -0.221409375194795 0.000575537836289103 NA NA NA hsa-miR-423-5p MYC 0.698807775906485 1.02195196334612e-11 -1.53204423111148 3.53987625613016e-10 miRNAWalker2_validate -0.328206409340035 0.00484551582134482 NA NA NA hsa-miR-15a-5p NF1 0.349521211668244 0.000770735998804736 -0.152901353808947 0.101850652339859 MirTarget -0.148929467960257 0.000666418015083739 NA NA NA hsa-miR-16-1-3p NF1 0.392360028038559 0.00112481918108198 -0.152901353808947 0.101850652339859 MirTarget -0.108815403058878 0.0039207534759359 NA NA NA hsa-miR-29a-5p NF1 -0.113555908626946 0.349622266470788 -0.152901353808947 0.101850652339859 MirTarget;miRNATAP -0.154669081021 3.62300802631363e-05 NA NA NA hsa-miR-455-5p NF1 -0.270546034117157 0.0581320703577731 -0.152901353808947 0.101850652339859 miRanda -0.117633756266104 0.00021315047674953 NA NA NA hsa-miR-590-5p NF1 -0.103355559980404 0.310027295317092 -0.152901353808947 0.101850652339859 miRanda -0.160993447815349 0.000340896843029157 NA NA NA hsa-miR-29a-5p NFATC2 -0.113555908626946 0.349622266470788 -1.87041062792181 1.43414339850833e-07 mirMAP;miRNATAP -0.583625441866098 5.86022160251471e-05 NA NA NA hsa-miR-30d-5p NFATC2 0.718283816348023 2.47422074061352e-08 -1.87041062792181 1.43414339850833e-07 MirTarget;mirMAP -0.429558488883224 0.00143308759494954 NA NA NA hsa-miR-125b-5p NFATC4 -1.35767721102906 1.16564617395164e-18 0.864010892322999 1.90169048902368e-05 mirMAP -0.224809010069414 0.000268845801695449 NA NA NA hsa-miR-130b-5p NFATC4 0.170599813152408 0.337611586432771 0.864010892322999 1.90169048902368e-05 mirMAP -0.223334355722899 6.08007516287365e-05 NA NA NA hsa-miR-29a-3p NFATC4 -0.856762511178136 4.65330336378459e-12 0.864010892322999 1.90169048902368e-05 miRNATAP -0.210278806007119 0.00743486328282441 NA NA NA hsa-miR-3607-3p NFATC4 -2.15518588554493 1.03390728226728e-23 0.864010892322999 1.90169048902368e-05 miRNATAP -0.174472801573825 6.00001387189594e-05 NA NA NA hsa-miR-15a-5p NFKB1 0.349521211668244 0.000770735998804736 -0.538916955748098 1.42993670239858e-08 miRNAWalker2_validate -0.153048958379264 0.000730484492411411 NA NA NA hsa-miR-548j-5p NFKB1 0.251239647701947 0.171361975450222 -0.538916955748098 1.42993670239858e-08 MirTarget -0.106885227436574 4.88574003092244e-05 NA NA NA hsa-miR-92a-3p NFKB1 0.212391012518195 0.134292268089997 -0.538916955748098 1.42993670239858e-08 miRNAWalker2_validate -0.147016189975437 8.47280185007855e-06 NA NA NA hsa-miR-423-5p NGF 0.698807775906485 1.02195196334612e-11 -1.13456502234037 7.24473953628721e-08 MirTarget;miRNATAP -0.447502128127762 6.35933337883299e-06 NA NA NA hsa-let-7g-5p NLK -0.461294133285527 2.17210114729901e-05 0.22134800606754 0.00116385654486987 miRNATAP -0.101066887340294 0.000890681375267317 NA NA NA hsa-let-7i-5p NLK -0.14267936165213 0.154141689875847 0.22134800606754 0.00116385654486987 miRNATAP -0.158130621990857 1.85250015482722e-06 NA NA NA hsa-miR-132-3p NLK 0.323796239695997 0.00272093067935091 0.22134800606754 0.00116385654486987 miRNATAP -0.128638110704715 2.68599518720146e-05 NA NA NA hsa-miR-140-5p NLK -0.220106443070144 0.0140713197101242 0.22134800606754 0.00116385654486987 MirTarget;PITA;miRanda;miRNATAP -0.103530034440285 0.00564970191186252 NA NA NA hsa-miR-23a-3p NLK -0.178875974460574 0.135978273540604 0.22134800606754 0.00116385654486987 miRNAWalker2_validate;MirTarget -0.179303032195093 4.45306067895512e-11 NA NA NA hsa-miR-27a-3p NLK -0.370807380415112 0.00875721956202713 0.22134800606754 0.00116385654486987 miRNATAP -0.148898136450612 9.12948651604776e-11 NA NA NA hsa-miR-511-5p NLK -1.75067415533112 3.37801163573342e-23 0.22134800606754 0.00116385654486987 MirTarget -0.104612392627311 2.15162536528134e-09 NA NA NA hsa-miR-542-3p NLK -1.31351015149842 3.64642423288576e-22 0.22134800606754 0.00116385654486987 miRanda;miRNATAP -0.139301025800919 1.05822598358559e-09 NA NA NA hsa-miR-324-5p NR4A1 0.372933276649782 0.00592280066108904 -2.32431301974999 3.6888067569463e-24 miRanda -0.390166540555856 7.11244870350508e-06 NA NA NA hsa-miR-361-5p NR4A1 0.233202959858696 0.00961572812255327 -2.32431301974999 3.6888067569463e-24 miRanda -0.481298783579483 0.000284512300406185 NA NA NA hsa-miR-93-5p NR4A1 1.39518349670953 2.84167728726712e-25 -2.32431301974999 3.6888067569463e-24 miRNAWalker2_validate -0.710204481874521 5.77807530080087e-19 NA NA NA hsa-let-7b-5p NRAS -0.959013717270803 5.95127281258643e-11 0.301156333096785 0.000285671613438218 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.105903409272711 8.57245668973746e-05 20607356 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells glioblastoma hsa-miR-126-5p NRAS -0.428561469405594 6.6035585844222e-05 0.301156333096785 0.000285671613438218 mirMAP -0.145651073417946 0.000106824688349933 NA NA NA hsa-miR-145-5p NRAS -1.4795885711477 6.47308361543414e-16 0.301156333096785 0.000285671613438218 miRNAWalker2_validate;MirTarget;miRNATAP -0.120395847533196 1.03194548202048e-08 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-22-3p NRAS -0.628561621952407 1.33755558015523e-09 0.301156333096785 0.000285671613438218 MirTarget;miRNATAP -0.287363482934569 1.84836871548684e-14 NA NA NA hsa-miR-29a-3p NRAS -0.856762511178136 4.65330336378459e-12 0.301156333096785 0.000285671613438218 miRNATAP -0.111209986118726 0.000497462508043792 NA NA NA hsa-miR-29b-3p NRAS -0.348885528720517 0.0121441341291285 0.301156333096785 0.000285671613438218 miRNATAP -0.163441778679427 1.31476396622707e-08 NA NA NA hsa-miR-29c-3p NRAS -1.4367517608807 1.61767774905781e-21 0.301156333096785 0.000285671613438218 miRNATAP -0.195416271463693 3.04370398757482e-15 NA NA NA hsa-miR-664a-3p NRAS 0.485807855553031 0.000732553249798598 0.301156333096785 0.000285671613438218 MirTarget -0.123577371649095 9.58480979576424e-06 NA NA NA hsa-miR-21-5p NTF3 1.51084295924322 1.54551622173259e-34 -3.97962534066229 2.44784627289438e-41 miRTarBase;miRNATAP -1.02982933864977 2.33503442659123e-19 NA NA NA hsa-miR-221-3p NTF3 1.12244756358612 3.48370308238012e-13 -3.97962534066229 2.44784627289438e-41 miRNATAP -0.487132834663555 1.03773554125066e-06 NA NA NA hsa-miR-222-3p NTF3 1.08574156066353 1.76407192348131e-11 -3.97962534066229 2.44784627289438e-41 miRNATAP -0.44960074696525 2.69176815020579e-06 NA NA NA hsa-miR-421 NTF3 0.941856334694081 6.12167297054077e-08 -3.97962534066229 2.44784627289438e-41 miRanda -0.509139650144783 1.28862404044202e-08 NA NA NA hsa-miR-590-5p NTF3 -0.103355559980404 0.310027295317092 -3.97962534066229 2.44784627289438e-41 PITA;miRanda;miRNATAP -0.438231227038025 0.00572599858717309 NA NA NA hsa-miR-107 NTRK2 0.241662461253461 0.0170788899505389 -2.30467079336051 6.66762032408277e-09 PITA;miRanda -1.0598585629804 4.58121558377307e-08 NA NA NA hsa-miR-130b-3p NTRK2 0.687190305027546 0.000109068658562255 -2.30467079336051 6.66762032408277e-09 mirMAP -0.437506702355608 6.88196102565667e-05 NA NA NA hsa-miR-130b-5p NTRK2 0.170599813152408 0.337611586432771 -2.30467079336051 6.66762032408277e-09 mirMAP -0.366083689585264 0.000970429145511043 NA NA NA hsa-miR-140-3p NTRK2 0.546012239205329 4.84578261098777e-11 -2.30467079336051 6.66762032408277e-09 PITA -0.621765702538706 0.00841531471617843 NA NA NA hsa-miR-148a-5p NTRK2 -0.767626696027761 1.08359477494797e-06 -2.30467079336051 6.66762032408277e-09 mirMAP -0.636528653670575 2.11782031176256e-07 NA NA NA hsa-miR-151a-5p NTRK2 0.484893436232714 4.8995594459361e-06 -2.30467079336051 6.66762032408277e-09 miRNATAP -1.33321264979205 1.53079430764618e-13 NA NA NA hsa-miR-17-3p NTRK2 0.410352776142368 0.00422200500748636 -2.30467079336051 6.66762032408277e-09 miRNATAP -0.453219975208752 0.000970000263503074 NA NA NA hsa-miR-185-5p NTRK2 0.480006257154717 6.35758891340152e-07 -2.30467079336051 6.66762032408277e-09 mirMAP -0.706902324923139 0.000526512526055176 NA NA NA hsa-miR-186-5p NTRK2 -0.060103391373687 0.535288717081205 -2.30467079336051 6.66762032408277e-09 mirMAP -0.615456145703442 0.00282417325117072 NA NA NA hsa-miR-29a-5p NTRK2 -0.113555908626946 0.349622266470788 -2.30467079336051 6.66762032408277e-09 mirMAP -0.496197551946914 0.0024225319944222 NA NA NA hsa-miR-30d-5p NTRK2 0.718283816348023 2.47422074061352e-08 -2.30467079336051 6.66762032408277e-09 mirMAP -0.544492350069766 0.000308238247398339 NA NA NA hsa-miR-32-3p NTRK2 0.219109440121582 0.207217051619543 -2.30467079336051 6.66762032408277e-09 mirMAP -0.57730597526211 7.07844368508117e-07 NA NA NA hsa-miR-32-5p NTRK2 0.0806126674664016 0.548984992497432 -2.30467079336051 6.66762032408277e-09 mirMAP -0.873196576871784 1.76759042639064e-09 NA NA NA hsa-miR-361-5p NTRK2 0.233202959858696 0.00961572812255327 -2.30467079336051 6.66762032408277e-09 miRanda;mirMAP -0.961236007085446 1.26833159807763e-05 NA NA NA hsa-miR-374a-5p NTRK2 0.016390363747302 0.869784217438621 -2.30467079336051 6.66762032408277e-09 mirMAP -1.03030330133654 1.83192331027079e-07 NA NA NA hsa-miR-374b-5p NTRK2 -0.307538028546424 0.0030079617545972 -2.30467079336051 6.66762032408277e-09 mirMAP -0.718532230574976 0.000166156599301286 NA NA NA hsa-miR-421 NTRK2 0.941856334694081 6.12167297054077e-08 -2.30467079336051 6.66762032408277e-09 mirMAP -0.382342771285455 0.00064249983773967 NA NA NA hsa-miR-452-3p NTRK2 1.76909792952222 2.98172274671408e-10 -2.30467079336051 6.66762032408277e-09 mirMAP -0.190953329238523 0.00547983200575232 NA NA NA hsa-miR-452-5p NTRK2 1.91544498799508 1.81995982853313e-14 -2.30467079336051 6.66762032408277e-09 mirMAP -0.282969267239225 0.00019818202707022 NA NA NA hsa-miR-532-5p NTRK2 1.02729546510601 9.93318913966636e-16 -2.30467079336051 6.66762032408277e-09 PITA -0.875128303330166 2.62964705553226e-09 NA NA NA hsa-miR-590-5p NTRK2 -0.103355559980404 0.310027295317092 -2.30467079336051 6.66762032408277e-09 miRanda;mirMAP -0.691661076913071 0.00040270354048443 NA NA NA hsa-miR-618 NTRK2 0.13539895350352 0.517145913114103 -2.30467079336051 6.66762032408277e-09 mirMAP -0.622793706501262 8.5230387177889e-11 NA NA NA hsa-miR-26b-5p PAK1 -1.10804856399744 4.14176110314282e-22 0.490305811595647 8.62539331382885e-05 miRNAWalker2_validate -0.15891257466612 0.00180470284259943 NA NA NA hsa-miR-30c-1-3p PAK1 -1.39373825444537 6.39912952911454e-17 0.490305811595647 8.62539331382885e-05 MirTarget -0.113092896023759 0.00158300734497847 NA NA NA hsa-miR-548v PDGFA -0.27258775900243 0.176259917595269 1.77758746228644 4.60244665196294e-16 miRNATAP -0.278647806801463 4.33621753073177e-07 NA NA NA hsa-miR-576-5p PDGFA -0.377452008285847 0.00470735657343984 1.77758746228644 4.60244665196294e-16 mirMAP -0.349423515951374 2.28885449982783e-05 NA NA NA hsa-miR-140-5p PDGFB -0.220106443070144 0.0140713197101242 0.990792072539177 3.84799134063219e-14 miRanda -0.224478580392745 0.00250343524846709 NA NA NA hsa-miR-146b-3p PDGFB -1.20799545896423 2.19859530890688e-09 0.990792072539177 3.84799134063219e-14 miRNAWalker2_validate -0.116559540687373 0.000253813958503156 NA NA NA hsa-miR-26b-5p PDGFB -1.10804856399744 4.14176110314282e-22 0.990792072539177 3.84799134063219e-14 miRNAWalker2_validate -0.212037229772437 0.000102211416676722 NA NA NA hsa-miR-590-3p PDGFB -0.473167498047808 1.76652934637227e-05 0.990792072539177 3.84799134063219e-14 PITA;miRanda;miRNATAP -0.219997217412303 0.0002136212610643 NA NA NA hsa-miR-106b-5p PDGFRA 0.648901865047099 8.24870862047885e-09 -3.44515402293711 2.35408080284508e-16 MirTarget;miRNATAP -0.667814276068908 0.000339494510953522 NA NA NA hsa-miR-20a-5p PDGFRA 0.854326758727003 5.04256669663285e-07 -3.44515402293711 2.35408080284508e-16 MirTarget;miRNATAP -0.429411714989606 0.000497563648177803 NA NA NA hsa-miR-219a-5p PDGFRA 0.17600389823009 0.322694100196276 -3.44515402293711 2.35408080284508e-16 MirTarget -0.52063936637308 1.57138286329894e-05 NA NA NA hsa-miR-34a-5p PDGFRA 1.03694231790865 5.74864019540594e-14 -3.44515402293711 2.35408080284508e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -1.20419826674778 7.99910511006868e-17 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-362-3p PDGFRA 0.814007335895913 2.00108618836568e-09 -3.44515402293711 2.35408080284508e-16 miRanda -0.626878498986425 4.42986522053939e-05 NA NA NA hsa-miR-374a-5p PDGFRA 0.016390363747302 0.869784217438621 -3.44515402293711 2.35408080284508e-16 mirMAP -0.904441562316791 2.39983127114498e-05 NA NA NA hsa-miR-374b-5p PDGFRA -0.307538028546424 0.0030079617545972 -3.44515402293711 2.35408080284508e-16 mirMAP -0.548120366479417 0.00796437271353305 NA NA NA hsa-miR-421 PDGFRA 0.941856334694081 6.12167297054077e-08 -3.44515402293711 2.35408080284508e-16 PITA;miRanda;miRNATAP -0.45565181782464 0.000157204289652031 NA NA NA hsa-miR-616-5p PDGFRA 0.150569904638223 0.402836556304524 -3.44515402293711 2.35408080284508e-16 mirMAP -0.412847880089754 0.000492619399212517 NA NA NA hsa-miR-93-5p PDGFRA 1.39518349670953 2.84167728726712e-25 -3.44515402293711 2.35408080284508e-16 MirTarget;miRNATAP -0.842533275875607 1.07321761969733e-08 NA NA NA hsa-miR-28-5p PDGFRB -0.430964830599964 2.67367257252925e-06 0.903688818724302 2.6429876964178e-08 miRanda -0.310145998507964 0.000393892179655548 NA NA NA hsa-miR-29a-3p PDGFRB -0.856762511178136 4.65330336378459e-12 0.903688818724302 2.6429876964178e-08 miRNATAP -0.17841922996433 0.00500595280694788 NA NA NA hsa-miR-29c-3p PDGFRB -1.4367517608807 1.61767774905781e-21 0.903688818724302 2.6429876964178e-08 miRNATAP -0.139148992716859 0.00615874031219039 NA NA NA hsa-miR-486-5p PDGFRB -1.77766890600022 2.9071717929922e-14 0.903688818724302 2.6429876964178e-08 miRanda -0.142065402424595 1.73938186674638e-05 NA NA NA hsa-miR-106b-5p PLA2G12A 0.648901865047099 8.24870862047885e-09 -0.791023748042462 1.18231931629012e-15 mirMAP -0.266014267647959 5.9212435860407e-10 NA NA NA hsa-miR-140-5p PLA2G12A -0.220106443070144 0.0140713197101242 -0.791023748042462 1.18231931629012e-15 miRanda -0.148237117501735 0.00839228705095135 NA NA NA hsa-miR-17-5p PLA2G12A 0.698861147045461 2.43854106455398e-05 -0.791023748042462 1.18231931629012e-15 mirMAP -0.156166087311117 1.18493997052615e-07 NA NA NA hsa-miR-181a-5p PLA2G12A 0.250113435902954 0.0551933249319293 -0.791023748042462 1.18231931629012e-15 mirMAP -0.193778811048191 3.19565578842397e-07 NA NA NA hsa-miR-181b-5p PLA2G12A 0.488256489401108 0.00105321129419701 -0.791023748042462 1.18231931629012e-15 mirMAP -0.187398478397273 1.16778168992629e-08 NA NA NA hsa-miR-20a-5p PLA2G12A 0.854326758727003 5.04256669663285e-07 -0.791023748042462 1.18231931629012e-15 mirMAP -0.130236012494097 5.73845333718432e-06 NA NA NA hsa-miR-32-3p PLA2G12A 0.219109440121582 0.207217051619543 -0.791023748042462 1.18231931629012e-15 mirMAP -0.100135809509177 0.000715271422667235 NA NA NA hsa-miR-362-3p PLA2G12A 0.814007335895913 2.00108618836568e-09 -0.791023748042462 1.18231931629012e-15 miRanda -0.13534064202416 0.000168490865417192 NA NA NA hsa-miR-501-5p PLA2G12A 1.15231083477882 2.98906150004088e-10 -0.791023748042462 1.18231931629012e-15 miRNATAP -0.159698924847702 1.1258030900796e-09 NA NA NA hsa-miR-589-3p PLA2G12A 1.16846704028095 5.88525574424201e-11 -0.791023748042462 1.18231931629012e-15 mirMAP -0.18597386225482 8.57790590041378e-12 NA NA NA hsa-miR-625-3p PLA2G12A 0.242249841316603 0.181227779755078 -0.791023748042462 1.18231931629012e-15 mirMAP -0.135161844446821 6.99056150075446e-07 NA NA NA hsa-miR-92b-3p PLA2G12A 0.220374930803974 0.296187538889092 -0.791023748042462 1.18231931629012e-15 miRNAWalker2_validate -0.10091652542866 1.70520826049974e-05 NA NA NA hsa-miR-93-5p PLA2G12A 1.39518349670953 2.84167728726712e-25 -0.791023748042462 1.18231931629012e-15 mirMAP -0.31642455552352 2.26982563682874e-21 NA NA NA hsa-miR-1976 PLA2G12B -0.431472440543166 0.00324575010550946 -0.709043082048637 0.0159106564464709 MirTarget -0.454863439085783 2.8222658320172e-06 NA NA NA hsa-miR-28-5p PLA2G1B -0.430964830599964 2.67367257252925e-06 1.11218092480272 0.00100002877020529 miRanda -0.522539189337601 0.00380748163736023 NA NA NA hsa-miR-361-5p PLA2G2A 0.233202959858696 0.00961572812255327 -2.63355537093474 0.000185160572420402 miRanda -2.32115808913069 1.20165686326271e-09 NA NA NA hsa-miR-30c-2-3p PLA2G2D -1.39811819128587 3.66376924527665e-15 -0.885146609200152 0.0330899260748063 mirMAP -0.308953568974045 0.00508340182787345 NA NA NA hsa-miR-361-5p PLA2G4A 0.233202959858696 0.00961572812255327 -1.51782818803861 3.95172010500953e-09 miRanda -0.519567336876991 0.000291415934911842 NA NA NA hsa-miR-362-3p PLA2G4A 0.814007335895913 2.00108618836568e-09 -1.51782818803861 3.95172010500953e-09 miRanda -0.270784488699881 0.0035520338530453 NA NA NA hsa-miR-128-3p PLA2G5 0.289735108018712 0.0114419474207889 -1.41944375217114 6.19629138768315e-10 miRNAWalker2_validate -0.27681378716713 0.00574201580029315 NA NA NA hsa-miR-361-5p PLA2G5 0.233202959858696 0.00961572812255327 -1.41944375217114 6.19629138768315e-10 miRanda -0.491895928491166 0.000117994720629655 NA NA NA hsa-miR-589-3p PLA2G5 1.16846704028095 5.88525574424201e-11 -1.41944375217114 6.19629138768315e-10 MirTarget -0.251533188441071 7.7546591228512e-05 NA NA NA hsa-miR-590-5p PLA2G5 -0.103355559980404 0.310027295317092 -1.41944375217114 6.19629138768315e-10 miRanda -0.405592480648136 0.000336021206784067 NA NA NA hsa-miR-30a-3p PLA2G6 -1.52720594401486 1.3830066075708e-17 1.15734672432699 4.00326986916457e-16 miRNATAP -0.2445503962837 1.00180247722334e-10 NA NA NA hsa-miR-106b-5p PPM1A 0.648901865047099 8.24870862047885e-09 -0.491863739444724 3.59260984655925e-09 mirMAP -0.232434357877877 5.6044701913444e-11 NA NA NA hsa-miR-140-3p PPM1A 0.546012239205329 4.84578261098777e-11 -0.491863739444724 3.59260984655925e-09 miRNATAP -0.157873410673319 0.00132486074431374 NA NA NA hsa-miR-15a-5p PPM1A 0.349521211668244 0.000770735998804736 -0.491863739444724 3.59260984655925e-09 MirTarget;miRNATAP -0.115578731408347 0.00369546544308881 NA NA NA hsa-miR-17-5p PPM1A 0.698861147045461 2.43854106455398e-05 -0.491863739444724 3.59260984655925e-09 TargetScan;mirMAP -0.117506143799233 1.59295052947885e-06 NA NA NA hsa-miR-21-3p PPM1A -0.484219378716006 0.00299941098417659 -0.491863739444724 3.59260984655925e-09 MirTarget -0.14757126985842 2.69145680315522e-09 NA NA NA hsa-miR-23a-3p PPM1A -0.178875974460574 0.135978273540604 -0.491863739444724 3.59260984655925e-09 mirMAP -0.186189979970517 4.88737993101547e-08 NA NA NA hsa-miR-29a-5p PPM1A -0.113555908626946 0.349622266470788 -0.491863739444724 3.59260984655925e-09 MirTarget;mirMAP;miRNATAP -0.107100904429632 0.00171138556716379 NA NA NA hsa-miR-421 PPM1A 0.941856334694081 6.12167297054077e-08 -0.491863739444724 3.59260984655925e-09 miRanda -0.13116925549001 1.37429121344418e-08 NA NA NA hsa-miR-500a-5p PPM1A 0.797906382969156 9.15958171084226e-08 -0.491863739444724 3.59260984655925e-09 mirMAP -0.140330298377363 1.89833542040787e-07 NA NA NA hsa-miR-532-5p PPM1A 1.02729546510601 9.93318913966636e-16 -0.491863739444724 3.59260984655925e-09 miRNATAP -0.106757356489667 0.000605033834383477 NA NA NA hsa-miR-590-5p PPM1A -0.103355559980404 0.310027295317092 -0.491863739444724 3.59260984655925e-09 miRanda -0.169547477956562 3.10271819685777e-05 NA NA NA hsa-miR-93-5p PPM1A 1.39518349670953 2.84167728726712e-25 -0.491863739444724 3.59260984655925e-09 mirMAP -0.197485181572356 2.83617149244477e-12 NA NA NA hsa-miR-106b-5p PPM1B 0.648901865047099 8.24870862047885e-09 -0.275687173108442 0.000442253436356182 miRNAWalker2_validate -0.153173521275482 4.37540440555824e-06 NA NA NA hsa-miR-107 PPM1B 0.241662461253461 0.0170788899505389 -0.275687173108442 0.000442253436356182 miRanda -0.123545813062675 0.00115412047872275 NA NA NA hsa-miR-146b-5p PPM1B 0.419719546795449 0.0457375823220155 -0.275687173108442 0.000442253436356182 miRanda -0.105221645375473 4.19521559325583e-09 NA NA NA hsa-miR-181a-5p PPM1B 0.250113435902954 0.0551933249319293 -0.275687173108442 0.000442253436356182 mirMAP;miRNATAP -0.129226988201477 9.94632310168721e-06 NA NA NA hsa-miR-181b-5p PPM1B 0.488256489401108 0.00105321129419701 -0.275687173108442 0.000442253436356182 mirMAP;miRNATAP -0.114997723841133 6.11079243851445e-06 NA NA NA hsa-miR-339-5p PPM1B 0.280589919878422 0.0355660282647215 -0.275687173108442 0.000442253436356182 miRanda -0.128616578334966 6.60550706493719e-06 NA NA NA hsa-miR-342-3p PPM1B -0.319677314984262 0.0449813878317147 -0.275687173108442 0.000442253436356182 miRanda -0.104809142943619 1.12088175217303e-05 NA NA NA hsa-miR-361-5p PPM1B 0.233202959858696 0.00961572812255327 -0.275687173108442 0.000442253436356182 miRanda -0.141904687515111 0.000937219004709175 NA NA NA hsa-miR-421 PPM1B 0.941856334694081 6.12167297054077e-08 -0.275687173108442 0.000442253436356182 PITA;miRanda -0.122726672018132 1.0453100472689e-08 NA NA NA hsa-miR-501-3p PPM1B 0.999540908940094 2.77358485581974e-11 -0.275687173108442 0.000442253436356182 PITA;miRNATAP -0.151373529026636 6.31406034198952e-10 NA NA NA hsa-miR-590-5p PPM1B -0.103355559980404 0.310027295317092 -0.275687173108442 0.000442253436356182 miRanda -0.130121209772947 0.000597865266532735 NA NA NA hsa-miR-93-3p PPM1B 0.402821129107592 0.00131324842735588 -0.275687173108442 0.000442253436356182 miRNATAP -0.143333737128232 2.20453008395152e-06 NA NA NA hsa-miR-106b-5p PPP3CA 0.648901865047099 8.24870862047885e-09 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.191067063648852 3.69747843513626e-08 NA NA NA hsa-miR-17-3p PPP3CA 0.410352776142368 0.00422200500748636 -0.536165287387848 2.77787023947662e-11 MirTarget -0.148715997251777 6.8452735631761e-08 NA NA NA hsa-miR-17-5p PPP3CA 0.698861147045461 2.43854106455398e-05 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.143640408234319 1.13035407609444e-09 NA NA NA hsa-miR-20a-5p PPP3CA 0.854326758727003 5.04256669663285e-07 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.13596145796804 2.84983869383186e-09 NA NA NA hsa-miR-21-5p PPP3CA 1.51084295924322 1.54551622173259e-34 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.143821297395015 1.2695170248385e-06 NA NA NA hsa-miR-30d-5p PPP3CA 0.718283816348023 2.47422074061352e-08 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.146138892286555 1.56191209956503e-06 NA NA NA hsa-miR-361-5p PPP3CA 0.233202959858696 0.00961572812255327 -0.536165287387848 2.77787023947662e-11 miRanda -0.145335005010698 0.00120607782460008 NA NA NA hsa-miR-501-3p PPP3CA 0.999540908940094 2.77358485581974e-11 -0.536165287387848 2.77787023947662e-11 MirTarget;PITA;miRNATAP -0.169069809996199 3.5765991379194e-11 NA NA NA hsa-miR-502-3p PPP3CA 0.659598854007546 3.01316453996423e-08 -0.536165287387848 2.77787023947662e-11 MirTarget;PITA;miRNATAP -0.21026132041502 1.15384439121552e-10 NA NA NA hsa-miR-589-3p PPP3CA 1.16846704028095 5.88525574424201e-11 -0.536165287387848 2.77787023947662e-11 MirTarget -0.121264895830011 4.18270966031286e-08 NA NA NA hsa-miR-93-3p PPP3CA 0.402821129107592 0.00131324842735588 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.143288165599429 6.27730698290466e-06 NA NA NA hsa-miR-93-5p PPP3CA 1.39518349670953 2.84167728726712e-25 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.206462809599041 4.19505348801646e-14 NA NA NA hsa-miR-361-5p PPP3CC 0.233202959858696 0.00961572812255327 -0.442598423475551 4.06646193924103e-07 miRanda -0.159719077024821 0.00091909551904825 NA NA NA hsa-miR-106b-5p PPP3R1 0.648901865047099 8.24870862047885e-09 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.138661227962938 5.82082557526804e-07 NA NA NA hsa-miR-181a-5p PPP3R1 0.250113435902954 0.0551933249319293 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.13691462952235 1.55708164198961e-08 NA NA NA hsa-miR-181b-5p PPP3R1 0.488256489401108 0.00105321129419701 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.13726473522507 5.36198845965272e-11 NA NA NA hsa-miR-181c-5p PPP3R1 -0.00639394152050299 0.969127212255928 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.116625763794141 9.00795108119744e-10 NA NA NA hsa-miR-24-3p PPP3R1 -0.257825594021966 0.00689742600215061 -0.348267739030591 8.30932335829799e-08 miRNAWalker2_validate -0.106343408108425 0.00160055709787487 NA NA NA hsa-miR-27a-3p PPP3R1 -0.370807380415112 0.00875721956202713 -0.348267739030591 8.30932335829799e-08 miRNATAP -0.117734120643401 1.31409589262749e-07 NA NA NA hsa-miR-93-5p PPP3R1 1.39518349670953 2.84167728726712e-25 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.108796059262154 9.63915967695639e-07 NA NA NA hsa-miR-15b-5p PRKACA 0.230566941413564 0.0824765001857479 -0.366734298281574 0.000187937709098459 miRNATAP -0.152941432259851 2.28347891457603e-05 NA NA NA hsa-miR-374b-3p PRKACA -0.137420230218985 0.305318192448799 -0.366734298281574 0.000187937709098459 mirMAP -0.12450872310223 0.000539430321626312 NA NA NA hsa-miR-744-5p PRKACA -0.378868377317939 0.00125071229180016 -0.366734298281574 0.000187937709098459 miRNAWalker2_validate -0.115884324772662 0.0046979329289167 NA NA NA hsa-miR-17-5p PRKACB 0.698861147045461 2.43854106455398e-05 -0.439902334736784 5.50105175875769e-05 TargetScan -0.144472658686219 5.56449338176546e-06 NA NA NA hsa-miR-193a-3p PRKACB -0.117675551589896 0.309391958208578 -0.439902334736784 5.50105175875769e-05 miRanda -0.138772633279135 0.00285551569786557 NA NA NA hsa-miR-19b-3p PRKACB 0.601279551368824 0.00016685097085251 -0.439902334736784 5.50105175875769e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.115986971473871 0.00048141723506022 NA NA NA hsa-miR-93-5p PRKACB 1.39518349670953 2.84167728726712e-25 -0.439902334736784 5.50105175875769e-05 miRNAWalker2_validate -0.135496406586043 0.000297518311204663 NA NA NA hsa-miR-142-5p PRKCA -1.44575553250033 1.18797044680592e-13 0.662827897377551 1.5305893364122e-08 mirMAP -0.253211662252116 4.3295868991415e-20 NA NA NA hsa-miR-146a-5p PRKCA -0.742958238440575 0.000765983177482633 0.662827897377551 1.5305893364122e-08 mirMAP -0.137245496572864 1.03630471721186e-07 NA NA NA hsa-miR-150-5p PRKCA -1.14624309254329 1.51365525978726e-06 0.662827897377551 1.5305893364122e-08 mirMAP -0.222341791889769 1.93250353571038e-22 NA NA NA hsa-miR-181a-5p PRKCA 0.250113435902954 0.0551933249319293 0.662827897377551 1.5305893364122e-08 mirMAP -0.254408568412877 7.16377375327665e-09 NA NA NA hsa-miR-181b-5p PRKCA 0.488256489401108 0.00105321129419701 0.662827897377551 1.5305893364122e-08 mirMAP -0.205095445188407 8.90870928470555e-08 NA NA NA hsa-miR-181c-5p PRKCA -0.00639394152050299 0.969127212255928 0.662827897377551 1.5305893364122e-08 mirMAP -0.183322604105065 1.38074332954132e-07 NA NA NA hsa-miR-1976 PRKCA -0.431472440543166 0.00324575010550946 0.662827897377551 1.5305893364122e-08 miRNATAP -0.183056349310667 3.0318716310551e-06 NA NA NA hsa-miR-218-5p PRKCA -0.500091158894849 0.0398595700240766 0.662827897377551 1.5305893364122e-08 mirMAP -0.148170646737725 2.1349888993316e-10 NA NA NA hsa-miR-22-5p PRKCA -0.630365901263172 3.32415348030414e-05 0.662827897377551 1.5305893364122e-08 mirMAP -0.251052842185981 1.31444858545747e-11 NA NA NA hsa-miR-2355-3p PRKCA -0.471227472721651 0.00718598113738346 0.662827897377551 1.5305893364122e-08 mirMAP -0.157103097222143 1.75080235522893e-06 NA NA NA hsa-miR-24-2-5p PRKCA -0.570999109789414 0.000447358572601571 0.662827897377551 1.5305893364122e-08 miRNAWalker2_validate -0.215395057998791 6.57823794606976e-10 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-29b-2-5p PRKCA -0.223258653034772 0.084306146519938 0.662827897377551 1.5305893364122e-08 mirMAP -0.18197054047472 4.89908312952123e-05 NA NA NA hsa-miR-330-3p PRKCA -0.332364259424489 0.0316051913061459 0.662827897377551 1.5305893364122e-08 mirMAP -0.210648698518416 2.68188227678048e-08 NA NA NA hsa-miR-381-3p PRKCA -1.11307533852141 4.70760087251745e-06 0.662827897377551 1.5305893364122e-08 mirMAP -0.100091563011784 1.9205952275757e-05 NA NA NA hsa-miR-450b-5p PRKCA -1.34333360369432 2.68386079790462e-17 0.662827897377551 1.5305893364122e-08 PITA;mirMAP;miRNATAP -0.224507062259025 6.89309401647265e-11 NA NA NA hsa-miR-495-3p PRKCA -0.751193061269953 0.00388779118736635 0.662827897377551 1.5305893364122e-08 mirMAP -0.103006977344404 3.01377161842223e-06 NA NA NA hsa-miR-505-3p PRKCA -1.20027021591555 1.27927500175937e-13 0.662827897377551 1.5305893364122e-08 miRNAWalker2_validate -0.100809044268482 0.00372474801967268 NA NA NA hsa-miR-654-3p PRKCA -1.72200544726291 6.91948971554614e-10 0.662827897377551 1.5305893364122e-08 mirMAP -0.104555302741979 1.91014801150244e-07 NA NA NA hsa-miR-194-5p PRKCB -0.292530160992458 0.0996141384876663 -1.62067363753233 3.76201992658756e-13 miRNATAP -0.310861421038956 6.51903986219064e-07 NA NA NA hsa-miR-23b-3p PRKCB -0.530561587109023 5.43807206823652e-07 -1.62067363753233 3.76201992658756e-13 mirMAP -0.286204121948097 0.00657996649038471 NA NA NA hsa-miR-30d-5p PRKCB 0.718283816348023 2.47422074061352e-08 -1.62067363753233 3.76201992658756e-13 mirMAP -0.362125630736335 2.22146697946039e-05 NA NA NA hsa-miR-361-5p PRKCB 0.233202959858696 0.00961572812255327 -1.62067363753233 3.76201992658756e-13 MirTarget;miRanda;miRNATAP -0.424918272347972 0.000711090604030861 NA NA NA hsa-miR-589-3p PRKCB 1.16846704028095 5.88525574424201e-11 -1.62067363753233 3.76201992658756e-13 mirMAP -0.228692909978861 0.000252673885842927 NA NA NA hsa-miR-589-5p PRKCB 1.18593770505086 1.01781241960531e-22 -1.62067363753233 3.76201992658756e-13 mirMAP -0.552773953594914 1.64276000301029e-10 NA NA NA hsa-miR-616-5p PRKCB 0.150569904638223 0.402836556304524 -1.62067363753233 3.76201992658756e-13 mirMAP -0.245704989615516 7.89898683278172e-05 NA NA NA hsa-miR-664a-3p PRKCB 0.485807855553031 0.000732553249798598 -1.62067363753233 3.76201992658756e-13 mirMAP -0.348212449855556 6.35284546408206e-06 NA NA NA hsa-miR-140-3p PRKX 0.546012239205329 4.84578261098777e-11 -0.240211607134995 0.240371070351319 mirMAP -0.414153706871003 0.000486275257531284 NA NA NA hsa-miR-148a-3p PRKX -0.748702855596996 3.93313343865641e-07 -0.240211607134995 0.240371070351319 MirTarget -0.590431480469924 2.08013051455884e-20 NA NA NA hsa-miR-16-1-3p PRKX 0.392360028038559 0.00112481918108198 -0.240211607134995 0.240371070351319 MirTarget -0.244568911489674 0.00313195084634789 NA NA NA hsa-miR-23b-3p PRKX -0.530561587109023 5.43807206823652e-07 -0.240211607134995 0.240371070351319 mirMAP -0.336626794798551 0.000311507204483922 NA NA NA hsa-miR-26b-3p PRKX -1.25503731613309 4.45390890119649e-27 -0.240211607134995 0.240371070351319 mirMAP -0.22275165341533 0.00569151212175373 NA NA NA hsa-miR-33a-5p PRKX -0.767474460958522 1.09948756118522e-05 -0.240211607134995 0.240371070351319 mirMAP -0.202109755439834 0.000339503602376678 NA NA NA hsa-miR-374a-3p PRKX -0.207171354826929 0.0623494608399903 -0.240211607134995 0.240371070351319 mirMAP -0.334277813432835 0.000202864124975447 NA NA NA hsa-miR-576-5p PRKX -0.377452008285847 0.00470735657343984 -0.240211607134995 0.240371070351319 mirMAP -0.216716249090268 0.00370148195253601 NA NA NA hsa-miR-126-3p PTPN7 -0.652349350198172 9.37876280344772e-09 0.257507660702991 0.242652755158724 miRNAWalker2_validate;miRTarBase -0.264013168408493 0.00472060267481571 NA NA NA hsa-miR-101-3p RAC1 -1.48176407980989 3.98950707385704e-31 0.216579201672401 0.00293326905874306 miRNAWalker2_validate;MirTarget -0.160619583159355 2.13421294167009e-10 25202416;24649082;25057058 In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR cell migration;; thyroid cancer;thyroid cancer;colorectal cancer hsa-miR-193b-3p RAC2 -0.166697207281748 0.272022543069482 -0.540909479889968 0.00736745718035675 miRNAWalker2_validate -0.246231671968469 0.000150422998204956 NA NA NA hsa-miR-125a-5p RAC3 -0.91219969372382 1.38256246489548e-07 0.670983769148776 0.00109278799508602 PITA -0.323616313906469 9.94727754352694e-09 NA NA NA hsa-miR-342-3p RAC3 -0.319677314984262 0.0449813878317147 0.670983769148776 0.00109278799508602 miRanda -0.17569839241443 0.00542104916104601 NA NA NA hsa-miR-106b-5p RAPGEF2 0.648901865047099 8.24870862047885e-09 -0.707388543717723 1.66316838166028e-08 MirTarget;miRNATAP -0.367901954164396 4.87508166763427e-12 NA NA NA hsa-miR-149-5p RAPGEF2 -0.317176971910036 0.187207559733877 -0.707388543717723 1.66316838166028e-08 miRNAWalker2_validate -0.121340167942735 2.36785214064497e-06 NA NA NA hsa-miR-155-5p RAPGEF2 0.0108524225071784 0.95651331033505 -0.707388543717723 1.66316838166028e-08 miRNAWalker2_validate;MirTarget -0.127471207566977 4.07796299788839e-05 NA NA NA hsa-miR-15a-5p RAPGEF2 0.349521211668244 0.000770735998804736 -0.707388543717723 1.66316838166028e-08 miRNATAP -0.215335862739807 0.000315799124198883 NA NA NA hsa-miR-17-5p RAPGEF2 0.698861147045461 2.43854106455398e-05 -0.707388543717723 1.66316838166028e-08 MirTarget;TargetScan;miRNATAP -0.268701808591923 1.09867946115169e-13 NA NA NA hsa-miR-19a-3p RAPGEF2 1.01712596153672 2.57753201450625e-07 -0.707388543717723 1.66316838166028e-08 MirTarget;miRNATAP -0.15405350886313 5.11854481863378e-07 NA NA NA hsa-miR-19b-3p RAPGEF2 0.601279551368824 0.00016685097085251 -0.707388543717723 1.66316838166028e-08 MirTarget;miRNATAP -0.1802486786036 2.58290295267383e-06 NA NA NA hsa-miR-20a-5p RAPGEF2 0.854326758727003 5.04256669663285e-07 -0.707388543717723 1.66316838166028e-08 MirTarget;miRNATAP -0.209073810761206 3.83769964779062e-09 NA NA NA hsa-miR-30d-5p RAPGEF2 0.718283816348023 2.47422074061352e-08 -0.707388543717723 1.66316838166028e-08 MirTarget;miRNATAP -0.151212213984442 0.00146399933077257 NA NA NA hsa-miR-331-3p RAPGEF2 -0.283974346994635 0.0373785411053202 -0.707388543717723 1.66316838166028e-08 MirTarget -0.138934199679307 0.00230772372667398 NA NA NA hsa-miR-339-5p RAPGEF2 0.280589919878422 0.0355660282647215 -0.707388543717723 1.66316838166028e-08 MirTarget;PITA -0.276020869800167 1.75869251449448e-09 NA NA NA hsa-miR-421 RAPGEF2 0.941856334694081 6.12167297054077e-08 -0.707388543717723 1.66316838166028e-08 miRanda;miRNATAP -0.21402112565083 6.70438483179358e-10 NA NA NA hsa-miR-582-3p RAPGEF2 -0.653831905315466 0.00248607706603299 -0.707388543717723 1.66316838166028e-08 PITA;miRNATAP -0.111005328970315 9.62365480489737e-05 NA NA NA hsa-miR-93-5p RAPGEF2 1.39518349670953 2.84167728726712e-25 -0.707388543717723 1.66316838166028e-08 MirTarget;miRNATAP -0.351472936185681 6.28057969034252e-17 NA NA NA hsa-miR-940 RAPGEF2 0.453020092551484 0.0177054921651997 -0.707388543717723 1.66316838166028e-08 MirTarget;PITA;miRNATAP -0.142329669384212 1.81628782072886e-05 NA NA NA hsa-miR-30b-5p RASA1 -0.54056186708617 2.44688760798341e-05 -0.0728742068751655 0.561743113598097 MirTarget -0.161690428976581 0.000636074752042687 NA NA NA hsa-miR-17-5p RASA2 0.698861147045461 2.43854106455398e-05 -0.727100402961242 0.00330690041503877 TargetScan -0.188066123659572 0.00961646193374891 NA NA NA hsa-miR-30d-5p RASA2 0.718283816348023 2.47422074061352e-08 -0.727100402961242 0.00330690041503877 mirMAP -0.279104027154393 0.00262879281861428 NA NA NA hsa-miR-195-5p RASGRF1 -1.85907534356434 1.47434041676402e-22 1.49106370660108 5.96975990261592e-05 mirMAP -0.26382335869635 0.00370723355782595 NA NA NA hsa-miR-331-5p RASGRF1 0.213759185384356 0.120772399478646 1.49106370660108 5.96975990261592e-05 miRNATAP -0.395652221732042 0.0030901408032086 NA NA NA hsa-miR-378c RASGRF1 -1.54028191929038 2.70131554214866e-15 1.49106370660108 5.96975990261592e-05 miRNATAP -0.248422441529015 0.00604478345599047 NA NA NA hsa-miR-675-3p RASGRF1 -2.78074157259259 1.41541888062227e-14 1.49106370660108 5.96975990261592e-05 MirTarget -0.169385354363106 0.000496721731134416 NA NA NA hsa-miR-144-3p RASGRF2 -2.97536914478815 6.00546047309683e-28 1.67547187518086 9.26708186095625e-17 MirTarget -0.116232217149536 0.000902582927491765 NA NA NA hsa-miR-17-5p RASGRF2 0.698861147045461 2.43854106455398e-05 1.67547187518086 9.26708186095625e-17 MirTarget;TargetScan -0.160047261889063 0.00898560880561526 NA NA NA hsa-miR-30d-3p RASGRF2 -0.120562286038759 0.329549534782125 1.67547187518086 9.26708186095625e-17 mirMAP -0.330098230904405 6.63464844250608e-05 NA NA NA hsa-miR-324-5p RASGRF2 0.372933276649782 0.00592280066108904 1.67547187518086 9.26708186095625e-17 miRNATAP -0.241797869008385 0.00133113176196231 NA NA NA hsa-miR-3614-5p RASGRF2 -1.66311416965679 1.26647181860439e-15 1.67547187518086 9.26708186095625e-17 MirTarget -0.149342879539691 0.00183074151317134 NA NA NA hsa-miR-429 RASGRF2 -1.40262535827285 6.93982219171912e-05 1.67547187518086 9.26708186095625e-17 miRanda -0.159646288111756 2.56535359334375e-08 NA NA NA hsa-miR-590-5p RASGRF2 -0.103355559980404 0.310027295317092 1.67547187518086 9.26708186095625e-17 miRanda -0.455005199224212 6.18498974335944e-06 NA NA NA hsa-miR-148a-3p RASGRP1 -0.748702855596996 3.93313343865641e-07 -0.453717444218552 0.0529724316830882 MirTarget -0.453369512761064 1.78337663608658e-09 NA NA NA hsa-miR-101-3p RASGRP3 -1.48176407980989 3.98950707385704e-31 0.366240287028941 0.0112314371168442 MirTarget -0.143683044248925 0.00513809938410704 NA NA NA hsa-miR-590-5p RASGRP3 -0.103355559980404 0.310027295317092 0.366240287028941 0.0112314371168442 miRanda -0.279983748673744 5.82948598319393e-05 NA NA NA hsa-miR-616-5p RASGRP4 0.150569904638223 0.402836556304524 -1.28007060385661 1.33669859072194e-14 MirTarget -0.157811276275036 0.000713751663631576 NA NA NA hsa-miR-26b-5p RELB -1.10804856399744 4.14176110314282e-22 0.630287006869072 6.44999146675304e-06 miRNAWalker2_validate -0.236282974751751 3.30378556245736e-05 NA NA NA hsa-miR-28-5p RELB -0.430964830599964 2.67367257252925e-06 0.630287006869072 6.44999146675304e-06 miRanda -0.329010744872339 9.92361813463075e-06 NA NA NA hsa-miR-17-5p RPS6KA1 0.698861147045461 2.43854106455398e-05 -0.0193982843076919 0.895272926505225 TargetScan;miRNATAP -0.150479492101603 0.000442310908893647 NA NA NA hsa-miR-20a-5p RPS6KA1 0.854326758727003 5.04256669663285e-07 -0.0193982843076919 0.895272926505225 miRNATAP -0.140420093444226 0.000724052018701145 NA NA NA hsa-miR-130b-5p RPS6KA2 0.170599813152408 0.337611586432771 -0.429936688183553 0.00940192295734202 mirMAP -0.213305958673466 2.2886761501014e-06 NA NA NA hsa-miR-17-5p RPS6KA2 0.698861147045461 2.43854106455398e-05 -0.429936688183553 0.00940192295734202 TargetScan -0.361293542462631 1.51868565926867e-14 NA NA NA hsa-miR-192-3p RPS6KA2 -0.6401165114007 0.000266272092403814 -0.429936688183553 0.00940192295734202 mirMAP -0.190995022600123 2.73504188366536e-05 NA NA NA hsa-miR-193a-3p RPS6KA2 -0.117675551589896 0.309391958208578 -0.429936688183553 0.00940192295734202 mirMAP -0.302358304666807 1.53272294304117e-05 NA NA NA hsa-miR-19a-3p RPS6KA2 1.01712596153672 2.57753201450625e-07 -0.429936688183553 0.00940192295734202 MirTarget -0.190446066307176 1.94564659739969e-06 NA NA NA hsa-miR-19b-3p RPS6KA2 0.601279551368824 0.00016685097085251 -0.429936688183553 0.00940192295734202 MirTarget -0.235922153431053 2.30069900396003e-06 NA NA NA hsa-miR-30d-5p RPS6KA2 0.718283816348023 2.47422074061352e-08 -0.429936688183553 0.00940192295734202 MirTarget;miRNATAP -0.222191844967225 0.000323873436695374 NA NA NA hsa-miR-3127-5p RPS6KA2 0.837385386388614 2.06679743975142e-07 -0.429936688183553 0.00940192295734202 mirMAP -0.204709957034024 3.28185871635773e-05 NA NA NA hsa-miR-532-3p RPS6KA2 0.297601533259956 0.014632205884815 -0.429936688183553 0.00940192295734202 MirTarget;mirMAP -0.296357914442727 7.3133532891582e-06 NA NA NA hsa-miR-589-5p RPS6KA2 1.18593770505086 1.01781241960531e-22 -0.429936688183553 0.00940192295734202 mirMAP -0.412829583412935 3.43368368308291e-11 NA NA NA hsa-miR-93-3p RPS6KA2 0.402821129107592 0.00131324842735588 -0.429936688183553 0.00940192295734202 MirTarget -0.482383363283909 1.2839051401815e-14 NA NA NA hsa-miR-181c-5p RPS6KA3 -0.00639394152050299 0.969127212255928 -0.0721830047612428 0.620235959053163 MirTarget;mirMAP;miRNATAP -0.132982978659169 0.00196775794236537 NA NA NA hsa-miR-497-5p RPS6KA3 -1.41371173021948 7.09278946477743e-17 -0.0721830047612428 0.620235959053163 MirTarget;miRNATAP -0.106167734324023 0.00837538561255109 NA NA NA hsa-miR-455-3p RPS6KA4 -1.3998033821095 5.72010709806871e-17 0.532916218348247 4.99919889760201e-13 PITA;miRNATAP -0.123389944483937 3.21577157483491e-09 NA NA NA hsa-miR-17-5p RPS6KA5 0.698861147045461 2.43854106455398e-05 -0.827283685514513 1.58444228442933e-05 MirTarget;TargetScan -0.174331110763624 0.00201607952288887 NA NA NA hsa-miR-18a-5p RPS6KA5 0.918028187958706 1.90229510425322e-05 -0.827283685514513 1.58444228442933e-05 MirTarget -0.165831784450617 0.000128839602274123 NA NA NA hsa-miR-140-3p RRAS2 0.546012239205329 4.84578261098777e-11 -0.429270018876791 0.000197234745399743 MirTarget;PITA;miRNATAP -0.190567380807172 0.00472931315051582 NA NA NA hsa-miR-16-1-3p SOS1 0.392360028038559 0.00112481918108198 0.05751534180893 0.493041822065916 mirMAP -0.102425524653968 0.00242014805702593 NA NA NA hsa-miR-17-5p SOS1 0.698861147045461 2.43854106455398e-05 0.05751534180893 0.493041822065916 MirTarget;TargetScan;miRNATAP -0.11660606180243 1.37071072811905e-06 NA NA NA hsa-miR-193a-3p SOS1 -0.117675551589896 0.309391958208578 0.05751534180893 0.493041822065916 miRanda -0.167375491584816 1.83548073403882e-06 NA NA NA hsa-miR-20a-5p SOS1 0.854326758727003 5.04256669663285e-07 0.05751534180893 0.493041822065916 MirTarget;miRNATAP -0.100063123806167 2.02695724421345e-05 NA NA NA hsa-miR-27a-3p SOS1 -0.370807380415112 0.00875721956202713 0.05751534180893 0.493041822065916 MirTarget;miRNATAP -0.120226883007702 2.62552416504337e-05 NA NA NA hsa-miR-30b-5p SOS1 -0.54056186708617 2.44688760798341e-05 0.05751534180893 0.493041822065916 mirMAP -0.125950231468023 6.21375879766061e-05 NA NA NA hsa-miR-339-5p SOS1 0.280589919878422 0.0355660282647215 0.05751534180893 0.493041822065916 miRNATAP -0.15315814967207 4.05818038840081e-07 NA NA NA hsa-miR-590-5p SOS1 -0.103355559980404 0.310027295317092 0.05751534180893 0.493041822065916 miRanda -0.115356122634493 0.00426551999929742 NA NA NA hsa-miR-146b-5p SOS2 0.419719546795449 0.0457375823220155 -0.326258424146275 0.000900714126323724 miRanda -0.110125845201631 1.10330856080798e-06 NA NA NA hsa-miR-21-5p SOS2 1.51084295924322 1.54551622173259e-34 -0.326258424146275 0.000900714126323724 miRNATAP -0.279899776012046 7.56477883436428e-16 NA NA NA hsa-miR-590-5p SOS2 -0.103355559980404 0.310027295317092 -0.326258424146275 0.000900714126323724 PITA;miRanda;miRNATAP -0.144457452099512 0.00241614674200376 NA NA NA hsa-miR-28-3p STK3 -0.312894403930205 0.00160942267379584 0.395433514833608 1.88083385820277e-05 MirTarget;PITA -0.171831662910923 0.000174921597629818 NA NA NA hsa-miR-30b-3p STK4 -0.439724365151373 0.000947180503583586 -0.0242791347989213 0.739245017925932 MirTarget -0.106247080459235 5.60224295282278e-05 NA NA NA hsa-miR-30d-3p STK4 -0.120562286038759 0.329549534782125 -0.0242791347989213 0.739245017925932 mirMAP -0.132656583256455 3.19899840746635e-06 NA NA NA hsa-miR-101-3p STMN1 -1.48176407980989 3.98950707385704e-31 1.91204257620119 3.19032860888253e-31 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.525610741856512 4.15373528715808e-18 NA NA NA hsa-miR-139-5p STMN1 -2.11299531796557 8.16407076415038e-28 1.91204257620119 3.19032860888253e-31 miRanda -0.471061981941114 2.33045488589164e-34 NA NA NA hsa-miR-199a-5p STMN1 -1.98848462405923 2.0421622713753e-11 1.91204257620119 3.19032860888253e-31 miRanda -0.164645683908432 3.88362205054513e-09 NA NA NA hsa-miR-26a-5p STMN1 -0.963792031426845 1.83360999387345e-22 1.91204257620119 3.19032860888253e-31 miRNATAP -0.435902366208077 1.39640550392348e-07 NA NA NA hsa-miR-26b-5p STMN1 -1.10804856399744 4.14176110314282e-22 1.91204257620119 3.19032860888253e-31 miRNATAP -0.420373582569013 3.06088143915777e-09 NA NA NA hsa-miR-30a-5p STMN1 -0.626257932887855 0.000108198196973765 1.91204257620119 3.19032860888253e-31 miRNAWalker2_validate -0.24310931882548 4.12676414766769e-06 NA NA NA hsa-miR-326 STMN1 -1.881935132554 1.68087316863775e-21 1.91204257620119 3.19032860888253e-31 miRanda -0.145029161663251 0.000540283853860901 NA NA NA hsa-miR-450b-5p STMN1 -1.34333360369432 2.68386079790462e-17 1.91204257620119 3.19032860888253e-31 PITA -0.277038227764649 8.8799126824721e-08 NA NA NA hsa-miR-542-3p STMN1 -1.31351015149842 3.64642423288576e-22 1.91204257620119 3.19032860888253e-31 miRanda -0.335552047275442 2.07296546212466e-08 NA NA NA hsa-miR-140-3p TAOK1 0.546012239205329 4.84578261098777e-11 -0.395598965266263 0.0493024563419061 mirMAP -0.305293275050068 0.00926148441073612 NA NA NA hsa-miR-17-5p TAOK1 0.698861147045461 2.43854106455398e-05 -0.395598965266263 0.0493024563419061 TargetScan;miRNATAP -0.219860637108768 0.000175692390785671 NA NA NA hsa-miR-18a-5p TAOK1 0.918028187958706 1.90229510425322e-05 -0.395598965266263 0.0493024563419061 MirTarget;miRNATAP -0.196151338983915 1.2870532845543e-05 NA NA NA hsa-miR-19a-3p TAOK1 1.01712596153672 2.57753201450625e-07 -0.395598965266263 0.0493024563419061 MirTarget;miRNATAP -0.148306153925696 0.00245893826058292 NA NA NA hsa-miR-19b-3p TAOK1 0.601279551368824 0.00016685097085251 -0.395598965266263 0.0493024563419061 MirTarget;miRNATAP -0.18747091921372 0.00214646020335936 NA NA NA hsa-miR-20a-5p TAOK1 0.854326758727003 5.04256669663285e-07 -0.395598965266263 0.0493024563419061 miRNATAP -0.188486126469257 0.000927273169437502 NA NA NA hsa-miR-29a-5p TAOK1 -0.113555908626946 0.349622266470788 -0.395598965266263 0.0493024563419061 mirMAP -0.285499583930732 0.000436645582440745 NA NA NA hsa-miR-29b-2-5p TAOK1 -0.223258653034772 0.084306146519938 -0.395598965266263 0.0493024563419061 MirTarget -0.226820068888694 0.00290778674209089 NA NA NA hsa-miR-30b-5p TAOK1 -0.54056186708617 2.44688760798341e-05 -0.395598965266263 0.0493024563419061 miRNAWalker2_validate;MirTarget -0.283739212169635 0.000189344321648577 NA NA NA hsa-miR-30d-3p TAOK1 -0.120562286038759 0.329549534782125 -0.395598965266263 0.0493024563419061 miRNATAP -0.275901434003531 0.000536228909200296 NA NA NA hsa-miR-30d-5p TAOK1 0.718283816348023 2.47422074061352e-08 -0.395598965266263 0.0493024563419061 MirTarget;miRNATAP -0.224531552298565 0.00282890312721742 NA NA NA hsa-miR-324-5p TAOK1 0.372933276649782 0.00592280066108904 -0.395598965266263 0.0493024563419061 miRanda -0.323914029478374 6.76055833670705e-06 NA NA NA hsa-miR-339-5p TAOK1 0.280589919878422 0.0355660282647215 -0.395598965266263 0.0493024563419061 miRanda -0.28528370002664 0.000102315560253821 NA NA NA hsa-miR-362-3p TAOK1 0.814007335895913 2.00108618836568e-09 -0.395598965266263 0.0493024563419061 miRanda -0.224841912028917 0.00155983785114077 NA NA NA hsa-miR-455-5p TAOK1 -0.270546034117157 0.0581320703577731 -0.395598965266263 0.0493024563419061 MirTarget;miRNATAP -0.296243768029307 1.5142502993155e-05 NA NA NA hsa-miR-501-5p TAOK1 1.15231083477882 2.98906150004088e-10 -0.395598965266263 0.0493024563419061 miRNATAP -0.141641578282415 0.00709049873585215 NA NA NA hsa-miR-502-5p TAOK1 0.892373335336396 1.7122694518919e-06 -0.395598965266263 0.0493024563419061 miRNATAP -0.147031630898638 0.00563921628244218 NA NA NA hsa-miR-769-3p TAOK1 0.618139013155289 0.000147293288426878 -0.395598965266263 0.0493024563419061 MirTarget;miRNATAP -0.161977620055444 0.00844630973671181 NA NA NA hsa-miR-93-5p TAOK1 1.39518349670953 2.84167728726712e-25 -0.395598965266263 0.0493024563419061 miRNATAP -0.181808957773081 0.00841456443217312 NA NA NA hsa-miR-142-5p TAOK2 -1.44575553250033 1.18797044680592e-13 0.679980728972071 1.86075577406525e-21 PITA;miRNATAP -0.128852704918319 2.98389325343296e-13 NA NA NA hsa-miR-106b-5p TAOK3 0.648901865047099 8.24870862047885e-09 0.0156206984472611 0.854924111029025 MirTarget -0.101831875725886 0.0051074911249347 NA NA NA hsa-miR-139-5p TGFB1 -2.11299531796557 8.16407076415038e-28 0.0791820105139553 0.6886056388594 miRanda -0.165335310650966 0.000359864512900183 NA NA NA hsa-miR-101-5p TGFB2 -1.0634649894055 4.39116719827902e-16 0.529934214584709 0.036730862150581 mirMAP -0.351880994764185 0.000113322446416492 NA NA NA hsa-miR-107 TGFB2 0.241662461253461 0.0170788899505389 0.529934214584709 0.036730862150581 miRanda -0.614314042069378 4.68765266846655e-07 NA NA NA hsa-miR-148a-3p TGFB2 -0.748702855596996 3.93313343865641e-07 0.529934214584709 0.036730862150581 MirTarget;miRNATAP -0.661431979951743 1.43220896593668e-16 NA NA NA hsa-miR-193a-3p TGFB2 -0.117675551589896 0.309391958208578 0.529934214584709 0.036730862150581 MirTarget;miRanda;miRNATAP -0.366329573810208 0.000659116520736421 NA NA NA hsa-miR-193b-3p TGFB2 -0.166697207281748 0.272022543069482 0.529934214584709 0.036730862150581 MirTarget;miRNATAP -0.318957683478265 9.08737208626492e-05 NA NA NA hsa-miR-33a-3p TGFB2 -0.683025859637737 1.01106097756419e-05 0.529934214584709 0.036730862150581 MirTarget;mirMAP -0.292910263006269 0.00021856118592367 NA NA NA hsa-miR-362-3p TGFB2 0.814007335895913 2.00108618836568e-09 0.529934214584709 0.036730862150581 miRanda -0.235702914624554 0.00870288726391307 NA NA NA hsa-miR-548b-3p TGFB2 -0.0203576084717134 0.930819503166956 0.529934214584709 0.036730862150581 MirTarget -0.251413034966269 2.19240613879876e-06 NA NA NA hsa-miR-616-5p TGFB2 0.150569904638223 0.402836556304524 0.529934214584709 0.036730862150581 mirMAP -0.373291858655729 4.43049125036333e-08 NA NA NA hsa-miR-618 TGFB2 0.13539895350352 0.517145913114103 0.529934214584709 0.036730862150581 MirTarget;miRNATAP -0.323812991792447 9.41184108923406e-08 NA NA NA hsa-miR-151a-5p TGFB3 0.484893436232714 4.8995594459361e-06 -0.549558180002636 0.00349778458392359 MirTarget -0.493845417648935 6.80157351019684e-09 NA NA NA hsa-miR-106b-5p TGFBR2 0.648901865047099 8.24870862047885e-09 -0.522706741081292 3.47206054315007e-05 miRNATAP -0.368277930860382 4.29748674542316e-12 NA NA NA hsa-miR-130b-3p TGFBR2 0.687190305027546 0.000109068658562255 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.131252693120461 0.000144540113312326 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 0.698861147045461 2.43854106455398e-05 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.203186001893041 2.94531720390227e-08 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-18a-5p TGFBR2 0.918028187958706 1.90229510425322e-05 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate -0.192780882131928 5.02272007870357e-12 NA NA NA hsa-miR-19a-3p TGFBR2 1.01712596153672 2.57753201450625e-07 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.149425406079401 1.09582904607366e-06 NA NA NA hsa-miR-19b-3p TGFBR2 0.601279551368824 0.00016685097085251 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.16137896859351 2.62064707293945e-05 NA NA NA hsa-miR-20a-5p TGFBR2 0.854326758727003 5.04256669663285e-07 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.177394018081005 6.48951647363697e-07 NA NA NA hsa-miR-21-5p TGFBR2 1.51084295924322 1.54551622173259e-34 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.236840105633096 2.41705180023436e-07 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-301a-3p TGFBR2 0.842910511640361 1.43446467417891e-06 -0.522706741081292 3.47206054315007e-05 miRNATAP -0.183722985598573 1.11942744399345e-07 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-501-3p TGFBR2 0.999540908940094 2.77358485581974e-11 -0.522706741081292 3.47206054315007e-05 TargetScan -0.116887889145825 0.0037841236086272 NA NA NA hsa-miR-590-5p TGFBR2 -0.103355559980404 0.310027295317092 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.253149374960949 3.5308611333711e-05 NA NA NA hsa-miR-92a-3p TGFBR2 0.212391012518195 0.134292268089997 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate -0.17351362748106 7.02401539230513e-05 NA NA NA hsa-miR-93-5p TGFBR2 1.39518349670953 2.84167728726712e-25 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.263677361634044 7.09611188180981e-10 NA NA NA hsa-miR-107 TNF 0.241662461253461 0.0170788899505389 -1.0038697460391 4.57018472897375e-05 miRanda -0.319449999519582 0.00803039535673001 NA NA NA hsa-miR-361-5p TNF 0.233202959858696 0.00961572812255327 -1.0038697460391 4.57018472897375e-05 miRanda -0.383465948256239 0.00478262683574898 NA NA NA hsa-let-7e-5p TNFRSF1A 0.0350298755544731 0.811068614727804 -0.779358458936897 4.22737006131824e-19 miRNAWalker2_validate -0.119647431964113 7.6612668803136e-05 NA NA NA hsa-miR-122-5p TP53 -1.23907441373955 4.42181244888642e-06 -0.163823087975333 0.268013799235932 miRNATAP -0.104401376732605 6.76735273123785e-05 23221562;22235305 Loss of miR-122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1-modulated P53 activity.;Surprisingly miR-122 overexpression decreased the sensitivity to the chemotherapy-induced apoptosis via a signaling circuit involving the activation of Akt and inhibition of p53 ; liver cancer;lymphoma hsa-miR-25-3p TP53 0.633062563556379 3.68686354834328e-10 -0.163823087975333 0.268013799235932 miRNAWalker2_validate -0.198477612132015 0.00480268903724675 22431589 The results define miR-25 and -32 as positive regulators of p53 underscoring their role in tumorigenesis in glioblastoma tumorigenesis glioblastoma hsa-miR-660-5p TRAF6 0.989755850734071 5.69930767464937e-14 -0.541448783334962 2.74576747727662e-09 MirTarget -0.124557792751236 0.000174154510344303 NA NA NA